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1. Escalona A, León F, Bellolio F, Pimentel F, Guajardo M, Gennero R, Cruz JP, Viviani P, Ibáñez L: [Gallbladder polyps: correlation between ultrasonographic and histopathological findings]. Rev Med Chil; 2006 Oct;134(10):1237-42
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  • [Title] [Gallbladder polyps: correlation between ultrasonographic and histopathological findings].
  • BACKGROUND: Gallbladder polyps are becoming a common finding.
  • AIM: To analyze the ultrasonographic and histopathologic findings of patients operated due to gallbladder polyps.
  • PATIENTS AND METHODS: The records of patients with ultrasonographic diagnosis of gallbladder polyp and that underwent cholecystectomy in a thirteen years period were reviewed, collecting their demographic, ultrasonographic and histopathological data.
  • Four cases of adenoma (3.2%) were diagnosed; one of them had in situ carcinoma.
  • Polyp size was also a predictor of the presence of adenoma (p =0.043; confidence intervals: 1.006-1.424).
  • CONCLUSIONS: There is a good correlation between the size of the gallbladder polyp in ultrasonography and the size in the histopathology report.
  • Gallbladder adenoma is uncommon and it correlates with the size of the polyp.
  • In this series, size was the only predictor of the presence of adenoma.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology. Polyps / pathology

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  • (PMID = 17186092.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Chile
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2. Di Carlo I, Toro A, Pulvirenti E, Zisa M, Galia A: An unusual association of diffuse adenomyomatosis with dysplastic adenoma in chronic calculous cholecystitis: case presentation. BMC Gastroenterol; 2010;10:41
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  • [Title] An unusual association of diffuse adenomyomatosis with dysplastic adenoma in chronic calculous cholecystitis: case presentation.
  • BACKGROUND: Gallbladder adenomyomatosis is an epithelial proliferation and hypertrophy of the muscularis mucosae of the gallbladder.
  • The segmental adenomyomatosis has a higher risk of developing into gallbladder carcinoma, especially in the fundal region of elderly patients.We report the case of a patient affected by chronic calculous cholecystitis with diffuse adenomyomatosis associated with dysplastic adenoma.
  • The definitive pathological examination of the gallbladder showed: multiple stones of cholesterol origin; diffuse mucosal adenomyomatosis; and a 1.1 cm pedunculated mass localized at the fundus, whose surface was lumpy.
  • This mass was diagnosed as an adenoma with multiple areas of severe dysplasia.
  • CONCLUSIONS: The adenoma of the gallbladder, together with the dysplasia, represents a biological carcinogenetic model.
  • Degenerative risk suggests surgery should be mandatory when there is a concomitant presence of large adenoma and adenomyomatosis.
  • [MeSH-major] Adenoma / diagnosis. Adenomyoma / diagnosis. Cholecystitis / diagnosis. Gallbladder Neoplasms / diagnosis

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  • (PMID = 20423477.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2890701
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3. Vialle R, Velasco S, Milin S, Bricot V, Richer JP, Levillain PM, Tasu JP: [Imaging in the diagnosis and the staging of gallbladder tumors]. Gastroenterol Clin Biol; 2008 Nov;32(11):931-41
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  • [Title] [Imaging in the diagnosis and the staging of gallbladder tumors].
  • [Transliterated title] Place de l'imagerie dans le diagnostic et le bilan des tumeurs de la vésicule biliaire.
  • Most of gallbladder tumors are benign.
  • Adenoma, cholesterol polyps, or adenomyomatosis are most frequently typical on ultrasonographic images.
  • In case of suspicious polyp or suspicious wall thickening, endoscopic ultrasonography can be helpful to evaluate local tumoral spread and eliminate differential diagnosis.
  • Unfortunately, diagnosis of gallbladder cancer is often late, when surgical resection can't be curative.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis

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  • (PMID = 18954953.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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4. Turrini R, Lanzani G, Salmi A: [Gallbladder adenoma with focal adenocarcinoma: a case report]. Recenti Prog Med; 2007 Oct;98(10):506-8
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  • [Title] [Gallbladder adenoma with focal adenocarcinoma: a case report].
  • [Transliterated title] Adenoma con focale adenocarcinoma della colecisti: descrizione di un caso.
  • Gallbladder polyps represent a frequent and asymptomatic finding on abdominal sonography.
  • We describe the ultrasound features of an asymptomatic 13-mm gallbladder polyp in a 29-year-old male.
  • Video-laparoscopic cholecystectomy was performed, and histological examination of the lesion revealed a severely dysplastic tubular adenoma and chronic cholecystitis.
  • To our knowledge, this is the first report of a gallbladder polyp already presenting severe dysplasia in a young Caucasian male without risk factors.
  • [MeSH-major] Adenoma / diagnosis. Cholecystectomy, Laparoscopic. Gallbladder Neoplasms / diagnosis. Polyps / complications
  • [MeSH-minor] Adult. Cholecystitis / complications. Cholecystitis / diagnosis. Cholecystitis / surgery. Chronic Disease. Humans. Male. Video-Assisted Surgery

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  • (PMID = 17970176.001).
  • [ISSN] 0034-1193
  • [Journal-full-title] Recenti progressi in medicina
  • [ISO-abbreviation] Recenti Prog Med
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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5. Zhang L, Han F, Huang CS, Pang C, Han YZ, Hua YW: [Analysis of the treatment of unexpected gallbladder cancer]. Zhonghua Wai Ke Za Zhi; 2005 Apr 1;43(7):460-2
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  • [Title] [Analysis of the treatment of unexpected gallbladder cancer].
  • OBJECTIVE: To investigate the secondary operation methods and the effects on the prognosis of unexpected gallbladder cancer (UGC).
  • The 41 patients had undergone gallbladder excision because of cholecystitis complicated lithiasis of gallbladder (32 cases), polypi of gallbladder or adenoma (9 cases).
  • Postoperative pathology showed that 32 cases were adenocarcinoma of gallbladder, 6 cases were squamous carcinoma, 3 cases were squamous adenocarcinoma.
  • The second operation chose the improved method of Glenn excision of carcinoma of gallbladder.
  • RESULTS: On the second operation, 14 cases were with lymphatic metastasis, 14 with gallbladder metastasis, 6 with bile duct metastasis, 2 with pancreas metastasis.
  • [MeSH-major] Cholecystectomy / methods. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / surgery

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  • (PMID = 15854374.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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6. Wang SN, Chung SC, Tsai KB, Chai CY, Chang WT, Kuo KK, Chen JS, Lee KT: Aberrant p53 expression and the development of gallbladder carcinoma and adenoma. Kaohsiung J Med Sci; 2006 Feb;22(2):53-9
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  • [Title] Aberrant p53 expression and the development of gallbladder carcinoma and adenoma.
  • Gallbladder carcinoma (GBC) is a highly lethal but relatively rare neoplasm of the digestive tract.
  • The progression from gallbladder adenoma to carcinoma remains unclear.
  • In this study, we analyzed the expression patterns of the p53 protein in 22 cases of GBC, 17 cases of precursor lesions (16 gallbladder adenomas and 1 cystadenoma), and 15 cases of normal epithelia using immunohistochemical analysis.
  • We found that p53 expression was significantly increased in 59.1% (13/22) of GBC cases and in 17.6% (3/17) of gallbladder adenoma cases (p = 0.009).
  • [MeSH-major] Adenoma / chemistry. Gallbladder Neoplasms / chemistry. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 16568721.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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7. Lee JS, Lee KT, Jung JH, Ok SW, Choi SC, Lee KH, Lee JK, Heo JS, Choi SH, Rhee JC: [Factors associated with malignancy in gallbladder polyps without gallbladder stone]. Korean J Gastroenterol; 2008 Aug;52(2):97-105
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  • [Title] [Factors associated with malignancy in gallbladder polyps without gallbladder stone].
  • BACKGROUND/AIMS: The purpose of this study was to find the factors predicting the neoplastic polyp of gallbladder and analyze the size criteria associated with malignancy.
  • METHODS: A total of 354 subjects with gallbladder polyps confirmed by tissue pathology were included for the analysis.
  • The clinical and radiological features of the polyps were compared between the two groups (neoplastic vs. non-neoplastic) and in the three groups (non-neoplastic vs. adenoma vs. adenocarcinoma).
  • RESULTS: Of 354 patients, non-neoplastic polyps were observed in 229 (64.7%) patents, adenoma in 85 (24.0%) and adenocarcinoma in 40 (11.3%).
  • The mean diameter of non-neoplastic polyp, adenoma, and adenocarcinoma were 11.3+/-2.8 mm, 16.0+/-7.2 mm, and 27.0+/-8.9 mm, respectively.
  • The mean age of patients with non-neoplastic polyp, adenoma, and adenocarcinoma were 44.8+/-11.3, 49.9+/-12.5, and 60.8+/-9.6, respectively.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Adult. Aged. Aged, 80 and over. Data Interpretation, Statistical. Female. Humans. Male. Middle Aged. Odds Ratio. Predictive Value of Tests. ROC Curve

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  • (PMID = 19077501.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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8. Zins M, Boulay-Coletta I, Molinié V, Mercier-Pageyral B, Jullès MC, Rodallec M, Petit E, Berrod JL: [Imaging of a thickened-wall gallbladder]. J Radiol; 2006 Apr;87(4 Pt 2):479-93
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  • [Title] [Imaging of a thickened-wall gallbladder].
  • [Transliterated title] Imagerie des épaississements de la paroi vésiculaire.
  • Thickening of the gallbladder wall may result from a large spectrum of pathological conditions, intrinsic as well as extrinsic to the biliary tract, and may have different appearances.
  • Accurate diagnosis is usually established after a correlation of imaging findings, laboratory data and clinical history.
  • CT and MRI are complementary to US and have an increasing role in assessing a thickened-wall gallbladder.
  • [MeSH-major] Gallbladder Diseases / diagnosis
  • [MeSH-minor] Acalculous Cholecystitis / diagnosis. Acalculous Cholecystitis / radiography. Acalculous Cholecystitis / ultrasonography. Adenocarcinoma / diagnosis. Adenocarcinoma / radiography. Adenocarcinoma / ultrasonography. Adenoma / diagnosis. Adenoma / radiography. Adenoma / ultrasonography. Adenomyoma / diagnosis. Adenomyoma / radiography. Adenomyoma / ultrasonography. Cholecystitis, Acute / diagnosis. Cholecystitis, Acute / radiography. Cholecystitis, Acute / ultrasonography. Cholecystolithiasis / ultrasonography. Diagnosis, Differential. Female. Gallbladder / pathology. Gallbladder / ultrasonography. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / radiography. Gallbladder Neoplasms / ultrasonography. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16691177.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 48
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9. Nonogaki K, Hirooka Y, Itoh A, Kawashima H, Hara K, Uchida H, Kasugai T, Ohno E, Ohmiya N, Niwa Y, Goto H: [A case of gallbladder adenoma with wide base]. Nihon Shokakibyo Gakkai Zasshi; 2008 Jan;105(1):74-80
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  • [Title] [A case of gallbladder adenoma with wide base].
  • A 65-year-old man was referred for a gallbladder elevated lesion.
  • Abdominal US showed a hypoechoic tumor with wide base at the gallbladder body.
  • The maximum velocity of the gallbladder wall blood flow was 20 cm/s.
  • We diagnosed the lesion as gallbladder carcinoma with the depth of subserosa.
  • Cholecystectomy was performed and the tumor was diagnosed as tubular adenoma of the gallbladder.
  • A gallbladder adenoma with wide base is rare, here we report this case with the several considerations.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 18176045.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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10. Biswas PK: Carcinoma gallbladder. Mymensingh Med J; 2010 Jul;19(3):477-81
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  • [Title] Carcinoma gallbladder.
  • Carcinoma gallbladder (CaGb) is a rare disease.
  • However the risk of CaGb is increased in anomalous pancreaticobiliary duct junction (APBDJ), gall stones, xanthogranulomatus cholecystitis, calcified or porcelain gallbladder, cholelithiasis with typhoid carriers, gallbladder adenoma, red meat consumption and tobacco uses.
  • In early carcinoma of a gallbladder sign and symptoms mimic benign disease.
  • The diagnosis is established by ultrasonography, computerized tomography and guided fine needle aspiration cytology (FNAC).
  • Biochemical tests are of very little value in making a diagnosis.
  • Prognosis depends on early diagnosis and appropriate surgical excision.

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  • (PMID = 20639849.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] Bangladesh
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11. Ciurea S, Matei E, Petrisor P, Luca L, Boros M, Herlea V, Popescu I: Gallbladder adenoma with focal adenocarcinoma. Chirurgia (Bucur); 2008 May-Jun;103(3):355-8
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  • [Title] Gallbladder adenoma with focal adenocarcinoma.
  • The majority of polypoid lesions of the gallbladder are cholesterolosis pseudopolyps.
  • [MeSH-major] Adenocarcinoma. Adenoma. Gallbladder Neoplasms. Neoplasms, Multiple Primary

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  • (PMID = 18717288.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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12. Scarpa MG, Gamba PG, Greggio NA, Chiarenza SF, Fasoli L, Musi L, Zanon GF: Polypoid lesion of the gallbladder in childhood: case report and literature review. Pediatr Med Chir; 2008 Jan-Feb;30(1):45-7
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  • [Title] Polypoid lesion of the gallbladder in childhood: case report and literature review.
  • Gallbladder polypoid lesions are rare in the pediatric patient and sometimes represent an incidental finding.
  • A routine abdominal ultrasound (US) detected a gallbladder polypoid lesion 6 mm in diameter, initially considered a gallbladder adenoma.
  • How does the presence of symptoms worsen the diagnosis and lead to preferring a surgical approach (cholecystectomy) over an echographic follow-up?
  • [MeSH-major] Gallbladder Diseases / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Follow-Up Studies. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / ultrasonography. Humans. Male. Radiography, Abdominal. Remission, Spontaneous. Time Factors

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  • (PMID = 18491679.001).
  • [ISSN] 0391-5387
  • [Journal-full-title] La Pediatria medica e chirurgica : Medical and surgical pediatrics
  • [ISO-abbreviation] Pediatr Med Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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13. Katabi N: Neoplasia of gallbladder and biliary epithelium. Arch Pathol Lab Med; 2010 Nov;134(11):1621-7
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  • [Title] Neoplasia of gallbladder and biliary epithelium.
  • CONTEXT: Diagnosis of biliary neoplasia can be challenging but is essential for the appropriate clinical management of patients.
  • Therefore, it is important to recognize the morphologic features of the biliary neoplasms to report a correct diagnosis. OBJECTIVES:.
  • (1) To discuss the differential diagnosis of dysplasia in the gallbladder and differentiate dysplasia from reactive atypia and invasive carcinoma, (2) review the histologic features of adenoma and polypoid biliary lesions, (3) highlight the differential diagnosis of adenocarcinoma in liver biopsy, and (4) discuss the differential diagnosis of atypical biliary glandular lesions.
  • DATA SOURCES: Current English literature related to gallbladder and biliary neoplasia.
  • Careful examination of the histologic features of these lesions and familiarity with their morphology can help to achieve the correct diagnosis.
  • [MeSH-major] Adenoma / pathology. Bile Duct Neoplasms / pathology. Carcinoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Metaplasia / pathology

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  • (PMID = 21043815.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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14. Ito H, Hann LE, D'Angelica M, Allen P, Fong Y, Dematteo RP, Klimstra DS, Blumgart LH, Jarnagin WR: Polypoid lesions of the gallbladder: diagnosis and followup. J Am Coll Surg; 2009 Apr;208(4):570-5
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  • [Title] Polypoid lesions of the gallbladder: diagnosis and followup.
  • BACKGROUND: Polypoid lesions of the gallbladder (PLG) are commonly seen on ultrasonography (US), but optimal management of this problem is ill-defined.
  • Patients with infiltrative masses suspicious for gallbladder cancer were not included.
  • Neoplastic polyps (adenoma) were found in 10% of patients.
  • [MeSH-major] Gallbladder Diseases / ultrasonography. Polyps / ultrasonography
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Adenoma / ultrasonography. Adult. Aged. Aged, 80 and over. Cholecystectomy. Female. Gallbladder Neoplasms / pathology. Gallbladder Neoplasms / surgery. Gallbladder Neoplasms / ultrasonography. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19476792.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Hattori M, Inui K, Yoshino J, Miyoshi H, Okushima K, Nakamura Y, Naito T, Imaeda Y, Horibe Y, Hattori T, Nakazawa S: [Usefulness of contrast-enhanced ultrasonography in the differential diagnosis of polypoid gallbladder lesions]. Nihon Shokakibyo Gakkai Zasshi; 2007 Jun;104(6):790-8
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  • [Title] [Usefulness of contrast-enhanced ultrasonography in the differential diagnosis of polypoid gallbladder lesions].
  • We investigated the usefulness of contrast-enhanced ultrasonography for differential diagnosis of polypoid gallbladder lesions in 60 patients, consisting of gallbladder carcinoma in 20, adenoma in 2, benign polyp in 29, and adenomyomatosis in 9, comparing contrast enhancement patterns with pathologic findings.
  • In gallbladder carcinoma, the TIC rose from no contrast to early-phase contrast sooner than in other diseases.
  • Ultrasonographic contrast enhancement patterns show characteristic associations with pathologic findings and serve as valuable adjuncts in the diagnosis of gallbladder diseases.
  • [MeSH-major] Adenoma / ultrasonography. Gallbladder Neoplasms / ultrasonography. Polyps / ultrasonography. Ultrasonography, Doppler / methods
  • [MeSH-minor] Adenomyoma / pathology. Adenomyoma / ultrasonography. Contrast Media / administration & dosage. Diagnosis, Differential. Humans. Neoplasm Staging

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  • (PMID = 17548945.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
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16. Saldaña DG, de Acosta DA, Alemán HP, Gebrehiwot D, Torres E: Gallbladder endometrioma associated with obstructive jaundice and a serous ovarian cystic adenoma. South Med J; 2010 Dec;103(12):1250-2
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  • [Title] Gallbladder endometrioma associated with obstructive jaundice and a serous ovarian cystic adenoma.
  • The occurrence of pelvic endometriosis is not uncommon, but endometriosis of the gallbladder is extremely rare.
  • This report concerns another patient with gallbladder endometriosis, which formed two distinct lesions at the fundus of the organ.
  • Endometriosis should be considered in the differential diagnosis of a fertile woman with a painful mass, particularly if the mass is associated in size and tenderness with menstrual variability.
  • [MeSH-major] Cystadenoma, Serous / complications. Endometriosis / complications. Gallbladder Diseases / complications. Jaundice, Obstructive / complications. Ovarian Neoplasms / complications
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Gallbladder / pathology. Humans. Ovary / pathology

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  • (PMID = 21037517.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Kumagai Y, Kotanagi H, Ishida H, Komatsuda T, Furukawa K, Yamada M, Ohuchi S, Seki H, Sakusabe M: Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings. Abdom Imaging; 2006 Jul-Aug;31(4):449-52
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  • [Title] Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings.
  • There is a marked paucity of contrast-enhanced ultrasound (US) findings of gallbladder disease in the literature, and there is only one previous case of gallbladder adenoma.
  • US showed a 2-cm polypoid lesion at the gallbladder body.
  • The lesion was surgically resected, and was found to be an adenoma without cancer foci.
  • This case suggests that contrast-enhanced US is an effective tool in diagnosing a gallbladder adenoma.
  • [MeSH-major] Adenoma / ultrasonography. Gallbladder Neoplasms / ultrasonography

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  • (PMID = 16447086.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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18. Akatsu T, Aiura K, Shimazu M, Ueda M, Wakabayashi G, Tanabe M, Kawachi S, Kitajima M: Can endoscopic ultrasonography differentiate nonneoplastic from neoplastic gallbladder polyps? Dig Dis Sci; 2006 Feb;51(2):416-21
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  • [Title] Can endoscopic ultrasonography differentiate nonneoplastic from neoplastic gallbladder polyps?
  • The present study aimed to clarify the endoscopic ultrasonography (EUS) features of nonneoplastic (cholesterol polyps and adenomyomatosis) and neoplastic (adenoma and adenocarcinoma) gallbladder polyps and to evaluate the effectiveness and limitation of EUS in the differential diagnosis of these lesions.
  • We retrospectively compared EUS images with histologic findings in 29 surgical cases with gallbladder polyps with a diameter of 10 to 20 mm.
  • In conclusion, 69% (20/29) of gallbladder polyps larger than 10 mm that were preoperatively suspected of malignancy were nonneoplastic.
  • [MeSH-major] Adenocarcinoma / ultrasonography. Adenoma / ultrasonography. Endosonography. Gallbladder Diseases / ultrasonography. Gallbladder Neoplasms / ultrasonography. Polyps / ultrasonography
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16534690.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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19. Nagata S, Ajioka Y, Nishikura K, Watanabe G, Inoue T, Yamaguchi K, Watanabe H, Tanaka M, Tsuneyoshi M: Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: immunohistochemical analysis of mucin profile and CD10. Oncol Rep; 2007 Apr;17(4):721-9
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  • [Title] Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: immunohistochemical analysis of mucin profile and CD10.
  • Pyloric-gland type adenoma of the gallbladder is formed by proliferation of glands resembling pyloric glands, morphologically.
  • No previous report has described the cellular phenotype and differentiation of pyloric-gland type adenoma of the gallbladder, using CD10 as a marker of proper biliary phenotype.
  • Immunostainings were performed for mucin markers such as MUC5AC, human gastric mucin (HGM) for gastric foveolar type epithelium, MUC6, M-GGMC-1 for pyloric-gland type and MUC2 for intestinal goblet-cell type, and for CD10 as a proper biliary type marker on 58 pyloric-gland type adenomas of the gallbladder, as well as for p53, Ki-67 and CDX2.
  • Out of the 58 pyloric-gland type adenomas, >or=30% of adenoma cells were positive for MUC5AC in 22 (38%) tumors, HGM in 29 (50%), MUC6 in 58 (100%), M-GGMC-1 in 54 (93%), MUC2 in none (0%), and CD10 in 20 (34%).
  • MUC6 (P<0.001) and M-GGMC-1 (P<0.001) mucins were detected more frequently in pyloric-gland type adenomas, and CD10 expression was significantly decreased, compared with normal gallbladder epithelium (P=0.006).
  • In pyloric-gland type adenomas of the gallbladder, expression of pyloric-gland type mucins was observed with a high frequency, whereas intestinal goblet-cell mucins were rarely seen.
  • Pyloric-gland type adenomas of the gallbladder show a differentiation toward pyloric glands in terms of immunohistochemistry, as well as morphology, accompanied by co-expression of gastric foveolar and native biliary phenotypes.
  • [MeSH-major] Adenoma / chemistry. Adenoma / pathology. Gallbladder Neoplasms / chemistry. Gallbladder Neoplasms / pathology. Mucins / analysis. Neprilysin / analysis

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  • (PMID = 17342306.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Ki-67 Antigen; 0 / Mucins; 0 / Tumor Suppressor Protein p53; EC 3.4.24.11 / Neprilysin
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20. Albores-Saavedra J, Keenportz B, Bejarano PA, Alexander AA, Henson DE: Adenomyomatous hyperplasia of the gallbladder with perineural invasion: revisited. Am J Surg Pathol; 2007 Oct;31(10):1598-604
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  • [Title] Adenomyomatous hyperplasia of the gallbladder with perineural invasion: revisited.
  • We report 9 examples of segmental adenomyomatous hyperplasia of the gallbladder with perineural invasion.
  • Eight patients had gallbladder calculi.
  • The original pathologic diagnosis of adenocarcinoma was made in 5 patients and of "adenoma malignum" in one.
  • The second type was characterized by an extensively fibrotic gallbladder wall with numerous RASs but with few or no smooth muscle bundles and an expanded subserosal layer containing abundant nerve-trunks (3 cases).
  • The pseudoinvasive pattern of the RASs, reactive epithelial atypia, and the perineural and intraneural invasion probably contributed to the erroneous diagnosis of adenocarcinoma or "adenoma malignum."
  • [MeSH-major] Adenomyoma / pathology. Gallbladder / innervation. Gallbladder Diseases / pathology. Peripheral Nervous System / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Aged. Aged, 80 and over. Cholelithiasis / pathology. Cholelithiasis / surgery. Diagnosis, Differential. Female. Humans. Hyperplasia. Male. Middle Aged. Muscle, Smooth. Reoperation

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  • (PMID = 17895763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Spaziani E, Petrozza V, Di Filippo A, Picchio M, Ceci F, Miraglia A, Moretti V, Briganti M, Greco E, Pattaro G, De Angelis F, Salvadori C, Stagnitti F: [Gallbladder polypoid lesions. Three clinical cases with difficult diagnosis and literature review]. G Chir; 2010 Oct;31(10):439-42
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  • [Title] [Gallbladder polypoid lesions. Three clinical cases with difficult diagnosis and literature review].
  • [Transliterated title] Lesioni polipoidi della colecisti. Presentazione di tre casi clinici di "difficile" diagnosi e revisione della letteratura.
  • INTRODUCTION: Gallbladder polypoid lesions occur in 1.3%-6.9% of cases.
  • The preoperative diagnosis between benign, malignant and potentially malignant lesions is difficult.
  • The case 1 was a gallbladder diffuse adenomyomatosis; the ultrasound and the CT were of little help in defining preoperatively the nature and the gravity of the thickening.
  • DISCUSSION: The ultrasound is the most widely used diagnostic tool in the evaluation of gallbladder polypoid lesions; its accuracy is only 66%.
  • CONCLUSIONS: The preoperative diagnosis of the nature of gallbladder polypoid lesions is "difficult" and this justifies the lack of consensus on treatment.
  • However, the adenoma-carcinoma sequence, widely discussed in literature, can justifies to the use of CT, MR, PET and surgical treatment after an ultrasound examination.
  • [MeSH-major] Gallbladder Diseases / diagnosis. Polyps / diagnosis

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  • (PMID = 20939951.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
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22. Numata K, Oka H, Morimoto M, Sugimori K, Kunisaki R, Nihonmatsu H, Matsuo K, Nagano Y, Nozawa A, Tanaka K: Differential diagnosis of gallbladder diseases with contrast-enhanced harmonic gray scale ultrasonography. J Ultrasound Med; 2007 Jun;26(6):763-74
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  • [Title] Differential diagnosis of gallbladder diseases with contrast-enhanced harmonic gray scale ultrasonography.
  • OBJECTIVES: We evaluated the usefulness of contrast-enhanced harmonic gray scale ultrasonographic findings for differential diagnosis of gallbladder diseases.
  • METHODS: We evaluated contrast-enhanced harmonic gray scale ultrasonographic images from 33 patients with 35 polypoid gallbladder disease lesions larger than 10 mm in diameter, consisting of 12 biliary sludge lesions, 8 cholesterol polyps, 1 inflammatory polyp, 2 adenomas, and 12 carcinomas.
  • Lesions showing tumor vessels and tumor enhancement on contrast-enhanced harmonic gray scale ultrasonography were diagnosed as cholesterol polyp, inflammatory polyp, adenoma, or carcinoma.
  • Lesions with tumor enhancement and tortuous-type tumor vessels on contrast-enhanced harmonic gray scale ultrasonography were diagnosed as carcinomas, and the sensitivity, specificity, and accuracy of this diagnosis with the current modality were 75% (9/12), 100% (23/23), and 91% (32/35), respectively.
  • CONCLUSIONS: Evaluation of tumor vessels on contrast-enhanced harmonic gray scale ultrasonography may be a useful modality for differentiating gallbladder carcinoma from other polypoid gallbladder disease lesions.
  • [MeSH-major] Gallbladder Diseases / ultrasonography. Image Enhancement / methods. Polysaccharides. Ultrasonography / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 17526608.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Polysaccharides; 127279-08-7 / SHU 508
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23. Tanaka S, Tanaka H, Yamamoto T, Shuto T, Takemura S, Hai S, Sakabe K, Uenishi T, Hirohashi K, Kubo S: Immunohistochemical demonstration of c-Kit protooncogene product in gallbladder cancer. J Hepatobiliary Pancreat Surg; 2006;13(3):228-34
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  • [Title] Immunohistochemical demonstration of c-Kit protooncogene product in gallbladder cancer.
  • BACKGROUND/PURPOSE: Although some gallbladder carcinomas are immunoreactive for c-Kit, the reasons for the c-Kit expression and its clinicopathologic implications are unknown.
  • We reviewed retrospectively, the clinicopathologic records of 47 patients who had undergone macroscopically complete gallbladder carcinoma resection.
  • Control tissue samples were from five gallbladder specimens each with chronic cholecystitis, polyp, and adenoma.
  • RESULTS: Cytoplasmic immunostaining for c-Kit was detected in 21 of the 47 gallbladder carcinomas (45%), and in 1 of the 15 control specimens (diagnosis, chronic cholecystitis).
  • However, microvessel density was significantly higher in c-Kit-positive gallbladder carcinoma compared with c-Kit-negative gallbladder carcinoma.
  • CONCLUSIONS: Gallbladder carcinomas positive for c-Kit are unlikely to arise from immature cells, but may be associated with neovascularization.
  • Angiogenesis inhibitors, such as tyrosine kinase inhibitors, therefore, may suppress the growth of some gallbladder cancers.
  • [MeSH-major] Gallbladder Neoplasms / metabolism. Gallbladder Neoplasms / pathology. Proto-Oncogene Proteins c-kit / metabolism

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  • (PMID = 16708300.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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24. Wiedmann M, Schoppmeyer K, Witzigmann H, Hauss J, Mössner J, Caca K: [Current diagnostics and therapy for carcinomas of the biliary tree and gallbladder]. Z Gastroenterol; 2005 Mar;43(3):305-15
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  • [Title] [Current diagnostics and therapy for carcinomas of the biliary tree and gallbladder].
  • Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumour, middle and distal extrahepatic tumours), gallbladder cancer, and ampullary carcinoma.
  • Transformation of normal into malignant bile duct tissue requires a chain of consecutive gene mutations, similar to the adenoma-dysplasia-carcinoma-sequence in colon cancer.
  • Abdominal ultrasound, combined non-invasive magnetic resonance cholangiography/tomography (MRC/MRT), and facultatively endoscopic retrograde cholangiography (ERC) for unclear diagnosis, represent the gold standard for primary diagnosis.
  • [MeSH-major] Bile Duct Neoplasms. Gallbladder Neoplasms
  • [MeSH-minor] Algorithms. Ampulla of Vater. Bile Ducts / pathology. Bile Ducts, Intrahepatic. Biopsy. Brachytherapy. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / therapy. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / therapy. Cyclooxygenase Inhibitors / therapeutic use. Gallbladder / pathology. Hepatectomy. Hepatic Duct, Common. Humans. Klatskin Tumor / diagnosis. Klatskin Tumor / therapy. Magnetic Resonance Imaging. Neoplasm Staging. Palliative Care. Retrospective Studies. Risk Factors. Stents. Time Factors

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  • [CommentIn] Z Gastroenterol. 2005 May;43(5):473-5 [15871071.001]
  • (PMID = 15765304.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors
  • [Number-of-references] 153
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25. Zülke C, Schlitt HJ: [Incidentalomas of the liver and gallbladder. Evaluation and therapeutic procedure]. Chirurg; 2007 Aug;78(8):698-712
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  • [Title] [Incidentalomas of the liver and gallbladder. Evaluation and therapeutic procedure].
  • The correct diagnosis of hepatic incidentaloma may be made in over 90% with non-invasive means.
  • The questionable diagnosis of "symptomatic" incidentaloma should undergo close scrutiny prior to a decision in favour of surgery.
  • With regard to more recent literature, the former "absolute" requirement for surgical resection in all cases of liver cell adenoma may have to be reappraised.
  • Percutaneous biopsies should not be performed due to oncological hazards, indeterminate results and potential for acute complications.The stage-oriented radical re-resection following diagnosis of an incidentally detected gallbladder cancer may lead to significantly improved long-term survival, especially in the early tumour stages T1b and T2, which represents the most common stage of gallbladder cancer in incidentaloma.
  • Patients at elevated risk for incidental gallbladder cancer should undergo thorough instruction with regard to the potential hazards of laparoscopic cholecystectomy.
  • Multimodal therapeutic strategies directed at advanced stages of incidentally detected gallbladder cancer should be evaluated in prospective multicentre studies.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Gallbladder Diseases / diagnosis. Gallbladder Neoplasms / diagnosis. Incidental Findings. Liver Diseases / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Algorithms. Biopsy. Cholecystectomy. Diagnosis, Differential. Diagnostic Imaging. Gallbladder / pathology. Hepatectomy. Humans. Lymph Node Excision. Lymphatic Metastasis. Neoplasm Staging. Patient Care Team. Prognosis

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  • (PMID = 17661000.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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26. Park KW, Kim SH, Choi SH, Lee WJ: Differentiation of nonneoplastic and neoplastic gallbladder polyps 1 cm or bigger with multi-detector row computed tomography. J Comput Assist Tomogr; 2010 Jan;34(1):135-9
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  • [Title] Differentiation of nonneoplastic and neoplastic gallbladder polyps 1 cm or bigger with multi-detector row computed tomography.
  • OBJECTIVE: To evaluate useful computed tomographic features to differentiate nonneoplastic and neoplastic gallbladder polyps 1 cm or bigger.
  • Gallbladder polyps were diagnosed by cholecystectomy.
  • CONCLUSIONS: Size bigger than 1.5 cm, sessile shape, and perception on unenhanced images are the main factors that differentiate neoplastic from nonneoplastic gallbladder polyps 1 cm or bigger.
  • [MeSH-major] Adenocarcinoma / radiography. Adenoma / radiography. Gallbladder Neoplasms / radiography. Polyps / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Age Distribution. Cholecystography / methods. Contrast Media. Diagnosis, Differential. Female. Gallbladder Diseases / radiography. Humans. Image Processing, Computer-Assisted / methods. Iopamidol. Male. Middle Aged. Observer Variation. Radiographic Image Enhancement / methods. Retrospective Studies

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  • (PMID = 20118736.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; JR13W81H44 / Iopamidol
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27. Lee YM, Lee JY, Kim MJ, Bae HI, Park JY, Kim SG, Kim DS: Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features. Cancer Sci; 2006 Nov;97(11):1205-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.
  • Gallbladder (GB) cancer is the most common malignant tumor of the biliary tract and is usually associated with gallstone disease, a late diagnosis, unsatisfactory treatment and a poor prognosis.
  • [MeSH-major] DNA Methylation. Gallbladder Neoplasms / genetics. Promoter Regions, Genetic / genetics. Ubiquitin Thiolesterase / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenoma / genetics. Adenoma / pathology. Azacitidine / pharmacology. CpG Islands. DNA, Neoplasm / genetics. DNA, Neoplasm / metabolism. Humans. Immunoenzyme Techniques. Microdissection. Neoplasm Invasiveness. Neoplasm Staging. Polymerase Chain Reaction. Tissue Array Analysis. Tumor Cells, Cultured

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  • (PMID = 16965602.001).
  • [ISSN] 1347-9032
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase; M801H13NRU / Azacitidine
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28. Lee SH, Lee DS, You IY, Jeon WJ, Park SM, Youn SJ, Choi JW, Sung R: [Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder]. Korean J Gastroenterol; 2010 Feb;55(2):119-26
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  • [Title] [Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder].
  • BACKGROUND/AIMS: In order to determine the malignant potential of gallbladder adenoma for progression to carcinoma, we evaluated the histopathologic features of adenoma and adenoma-related lesions on cholecystectomized specimens.
  • A pathologist reviewed all specimens and selected benign adenomas, CIS in the adenoma, and adenoma residue in invasive carcinomas.
  • Adenomas and adenoma-related lesions were classified according to morphology (tubular, tubulopapillary, and papillary) and the consisting epithelium (biliary, pyloric metaplasia, and intestinal metaplasia).
  • The age and the size of the benign adenomas and carcinomas in the adenoma were also compared.
  • RESULTS: Adenoma and adenoma-related lesions were found in 34 out (1.8%) of all resected gallbladder.
  • Among 9 CIS and 28 invasive carcinomas, adenoma-related lesions were detected in 7 and 1 case, respectively.
  • All eight carcinomas arising in the adenoma were well-differentiated solitary tumors.
  • The diameters of the carcinomas in the adenoma were, on average, larger than that of the benign adenomas (1.8 cm vs. 0.9 cm, p=0.01).
  • The patients with carcinomas in the adenoma were, on average, older than those with benign adenomas, although the difference was insignificant (57 years vs. 47 years, p=0.09).
  • The morphology and consisting epithelium did not differ between the benign adenomas and carcinomas in the adenoma.
  • CONCLUSIONS: Gallbladder adenoma is a rare disease, although malignant transformation occurs frequently.
  • Adenoma is a precancerous lesion and the adenoma-carcinoma sequence is one of the gallbladder cancer carcinogenesis.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 20168058.001).
  • [ISSN] 2233-6869
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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29. Ma HB, Hu HT, Di ZL, Wang ZR, Shi JS, Wang XJ, Li Y: Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. World J Gastroenterol; 2005 Feb 7;11(5):744-7
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  • [Title] Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma.
  • AIM: To investigate the role of cyclin D1, p16 and retinoblastoma in cancerous process of gallbladder carcinomas and to assess the relation between cyclin D1, p16, Rb and the biological characteristics of gallbladder carcinoma.
  • METHODS: Forty-one gallbladder carcinoma, 7 gallbladder adenoma and 14 chronic cholecystitis specimens were immunohistochemically and histopathologically investigated for the relation of cyclin D1, p16 and Rb with Nevin staging and pathologic grading.
  • RESULTS: The expression rates of abnormal cyclin D1 in gallbladder carcinoma (68.3%) and gallbladder adenoma (57.1%) were significantly higher than those in chronic cholecystitis (7.1%) (P<0.05).
  • No significant difference was found both among the pathological grades G(1), G(2) and G(3) and among Nevin stagings S(1)-S(2), S(3) and S(4)-S(5) of gallbladder carcinoma.
  • The positive rates of p16 (48.8%) and Rb (58.5%) in gallbladder carcinoma were significantly lower compared to those in adenoma (100.0%) and cholecystitis (100.0%) (P<0.05).
  • The positive rates of p16 and Rb in Nevin stagings S(1)-S(2) (80.0% and 90.0%) and S(3) (46.2% and 61.5%) gallbladder carcinomas were significantly higher than those in S(4)-S(5) (33.3% and 38.8%) (P<0.05), and those in pathologic grades G(1) (54.5% and 81.8%) and G(2) (50.0% and 62.5%) gallbladder carcinoma were significantly higher than those in G(3) (28.6% and 35.7%) (P<0.05).
  • The protein expression of p16 and Rb had a negative-correlation in gallbladder carcinoma (r = -0.2993, P<0.05), and this negative-correlation was correlated with Nevin staging (P<0.05).
  • Moreover, the protein expression of p16 and cyclin D1 had a negative-correlation in gallbladder carcinoma (r = -0.9417, P<0.05).
  • CONCLUSION: Cyclin D1 may play a role in the early stage of gallbladder carcinoma.
  • Mutation of p16 and Rb genes might be correlated with progression of gallbladder carcinoma.
  • Analysis of p16 and Rb can estimate the prognosis of gallbladder carcinoma.
  • Expression of p16 and Rb may be correlated with Nevin staging and pathologic grading in gallbladder carcinoma.
  • [MeSH-major] Adenoma / metabolism. Cyclin D1 / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Gallbladder Neoplasms / metabolism. Retinoblastoma Protein / metabolism


30. Lu HY, Zhang GQ, Li JC: [Study on genetic instability of nm23H1 gene in Chinese with original gallbladder tumor]. Fen Zi Xi Bao Sheng Wu Xue Bao; 2006 Jun;39(3):249-57
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  • [Title] [Study on genetic instability of nm23H1 gene in Chinese with original gallbladder tumor].
  • The aim of this study was to examine the microsatellite instability (MSI) and loss of heterozygosity (LOH) of locus D17S396 on chromosome 17 and their influence on the expression of nm23H1 in gallbladder tumors, which may provide experimental basis for the tumor occurrence and metastasis.
  • In our experiment, the frequency of genetic instability of malignant gallbladder tumors was 42.55%, which was higher than that of gallbladder adenomas, while there were no genetic instability occurred in chronic cholecystitis tissue.
  • The frequency of LOH seemed higher with the deteriorism of gallbladder tumor.
  • Among 47 gallbladder carcinomas, the frequency of LOH and MSI were different between different differentiation cases (P < 0.05), and the frequency of LOH in liver and lymph node metastasis cases was significantly higher than those without metastasis (P < 0.01).
  • The expression of nm23H1 in gallbladder carcinoma, gallbladder adenoma and chronic cholecystitis tissue were different (P < 0.05).
  • In gallbladder carcinomas, the positive frequency of nm23H1 protein in LOH positive group was lower than that of LOH negative group (P < 0.05).
  • The results indicated that the genetic instability of nm23H1 gene might be implicated in pathogenesis and progression of gallbladder tumor.
  • Both MSI and LOH of nm23H1 gene controlled the development of gallbladder tumor independently in different paths.
  • MSI may be an early stage molecule marker of gallbladder carcinoma.
  • LOH may be molecule marker for the deteriorism of gallbladder tissue, which could inhibit the expression of nm23H1 in local tissue of gallbladder carcinoma and endow it with high aggressive and poor prognosis.
  • Increasing the amount of nm23H1 protein expression could effectively restrain gallbladder carcinoma metastasis and improve prognosis of patients.

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  • (PMID = 16944600.001).
  • [ISSN] 1673-520X
  • [Journal-full-title] Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology
  • [ISO-abbreviation] Fen Zi Xi Bao Sheng Wu Xue Bao
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / NM23 Nucleoside Diphosphate Kinases
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31. Choi HJ, Yun SS, Kim HJ, Choi JH: Expression of p16 protein in gallbladder carcinoma and its precancerous conditions. Hepatogastroenterology; 2010 Jan-Feb;57(97):18-21
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  • [Title] Expression of p16 protein in gallbladder carcinoma and its precancerous conditions.
  • BACKGROUND/AIMS: Adenocarcinoma of the gallbladder is a highly malignant neoplasm. p16 is a tumor suppressor gene protein, which is a cyclin-dependent kinase inhibitor that regulates the G1-S phase of the cell cycle.
  • The purpose of the present study was to investigate the expression of p16 in gallbladder carcinoma and its precancerous conditions and to examine the relationship between p16 expression and clinicopathological parameters.
  • METHODOLOGY: Formalin-fixed, paraffin-embedded tissue sections from 20 cases of normal gallbladder, 20 cases of chronic cholecystitis, 20 cases of gallbladder adenoma, 20 cases of dysplasia, and 58 cases of adenocarcinoma were examined.
  • RESULTS: In normal gallbladder, no expression of p16 was found.
  • In gallbladder adenomas, expression of p16 was found in 20% (4/20).
  • In gallbladder adenocarcinomas, p16 expression was found in 27.6% (16/58).
  • CONCLUSIONS: P16 protein overexpression is an early and relatively common event in carcinogenesis of gallbladder carcinoma.
  • Expression of p16 may be an ancillary diagnostic marker of gallbladder carcinoma and its precancerous conditions.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Cholecystitis / metabolism. Gallbladder Neoplasms / metabolism. Neoplasm Proteins / metabolism. Precancerous Conditions / metabolism

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  • (PMID = 20422865.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Neoplasm Proteins; 0 / P16 protein, human
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32. Oh SJ, Lee SJ, Lee HY, Paik YH, Lee DK, Lee KS, Chung JB, Yu JS, Yoon DS: [Extrapancreatic tumors in intraductal papillary mucinous neoplasm of the pancreas]. Korean J Gastroenterol; 2009 Sep;54(3):162-6
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  • Five, six, and two extrapancreatic malignancies had been diagnosed before, during, and after the diagnosis of IPMN.
  • Other extrapancreatic tumors included lung cancer (n=2), prostatic cancer (n=1), renal cell carcinoma (n=1), cholangiocellular carcinoma (n=1), urinary bladder cancer (n=1), and gallbladder cancer (n=1), respectively.
  • As benign tumor, there were two gallbladder adenoma, one gastric adenoma, one colonic adenoma and one benign ovarian cystic neoplasm, respectively.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Second Primary / epidemiology. Pancreatic Neoplasms / diagnosis

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  • [CommentIn] Korean J Gastroenterol. 2009 Sep;54(3):196-8 [19844158.001]
  • (PMID = 19844152.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
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33. Nuernberg D, Ignee A, Dietrich CF: [Ultrasound in gastroenterology. Biliopancreatic system]. Med Klin (Munich); 2007 Feb 15;102(2):112-26
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  • GALLBLADDER: Ultrasound has become widely accepted for the diagnosis of gallbladder disease.
  • Gallbladder polyps are well detectable.
  • Gallbladder carcinomas as a disease of the older age with few early symptoms are usually detected at a late stage when the liver is already infiltrated.
  • Ductal adenocarcinoma seems to be less vascularized in comparison to the surrounding tissue, while endocrine tumors and macro- and microcystic adenoma are rather hypervascularized.
  • [MeSH-minor] Adenoma / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Intrahepatic / ultrasonography. Carcinoma / ultrasonography. Cholangiocarcinoma / ultrasonography. Cholangitis, Sclerosing / ultrasonography. Cholecystitis / ultrasonography. Choledocholithiasis / ultrasonography. Contrast Media. Diagnosis, Differential. Endosonography. Gallbladder Neoplasms / ultrasonography. Humans. Middle Aged. Pancreatic Neoplasms / ultrasonography. Pancreatitis / ultrasonography. Polyps / ultrasonography. Sensitivity and Specificity. Ultrasonography, Doppler, Color / methods

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  • (PMID = 17323018.001).
  • [ISSN] 0723-5003
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 228
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34. Colović R, Grubor N, Radak V, Micev M, Colović N, Stojković M: [Tubular adenoma of the gallbladder with squamous metaplasia]. Srp Arh Celok Lek; 2006 Mar-Apr;134(3-4):159-61
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  • [Title] [Tubular adenoma of the gallbladder with squamous metaplasia].
  • Adenomas of the gallbladder are rare tumors.
  • Tubular adenoma appears in middle aged and older patients, although it may develop even in children.
  • This is a case report of forty-year old woman in whom a polypoid lesion was discovered in the gallbladder during regular ultrasonographic control after the liver surgery for hemangioma.
  • The gallbladder was removed during an open surgery.
  • A polypoid tumour of 20x7x5mm in size on wide pedicle was found in the gallbladder.
  • Histology showed tubular adenoma with mild epithelial dysplasia in some places and with antral and squamous metaplasia.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 16915759.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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35. Wani Y, Notohara K, Fujisawa M: Aberrant expression of an "intestinal marker" Cdx2 in pyloric gland adenoma of the gallbladder. Virchows Arch; 2008 Nov;453(5):521-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aberrant expression of an "intestinal marker" Cdx2 in pyloric gland adenoma of the gallbladder.
  • The aim of this study was to survey Cdx2 expression in pyloric gland adenoma (PGA) of the gallbladder.
  • [MeSH-major] Adenoma / metabolism. Gallbladder Neoplasms / metabolism. Gastric Mucosa / metabolism. Homeodomain Proteins / metabolism

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  • [Cites] J Cancer Res Clin Oncol. 2005 May;131(5):271-8 [15645288.001]
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  • (PMID = 18843504.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CDX2 Transcription Factor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / beta Catenin
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36. Xu HX: Contrast-enhanced ultrasound in the biliary system: Potential uses and indications. World J Radiol; 2009 Dec 31;1(1):37-44

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  • However, it is lack of the ability to depict the microcirculation of some lesions which may lead to failure in diagnosis for some biliary diseases.
  • (2) For differentiation diagnosis between ICC and other tumors (i.e. hepatocellular carcinoma or liver metastasis) or infectious diseases;.
  • (3) For differentiation diagnosis between biliary cystadenoma and biliary cystadenocarcinoma;.
  • (6) To make a distinction between gallbladder cholesterol polyp, adenoma and polypoid cancer;.
  • (7) To make a distinction between chronic cholecystitis with thickened wall and gallbladder cancer;.
  • (8) For differentiation diagnosis between motionless sludge and gallbladder cancer;.
  • (9) For differentiation diagnosis between common bile duct cancer and sludge or stone without acoustic shadowing; and (10) In patients who are suspected of having a drop of their percutaneous transhepatic cholangiodrainage tube, US contrast agent can be administered to through the tube detect the site of the tube.

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  • (PMID = 21160719.001).
  • [ISSN] 1949-8470
  • [Journal-full-title] World journal of radiology
  • [ISO-abbreviation] World J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999303
  • [Keywords] NOTNLM ; Bile duct / Cholangiocarcinoma / Contrast-enhanced ultrasound / Gallbladder / Polypoid lesion / Ultrasound contrast agent
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37. Sohn VY, Arthurs ZM, Martin MJ, Sebesta JA, Branch JB, Champeaux AL: Incidental pathologic findings in open resectional gastric bypass specimens with routine cholecystectomy and appendectomy. Surg Obes Relat Dis; 2008 Sep-Oct;4(5):608-11
MedlinePlus Health Information. consumer health - Stomach Disorders.

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  • The purpose of this study was to determine the incidence of abnormal findings of the extirpated, gallbladder, appendix, and distal stomach after gastric bypass surgery.
  • In the gallbladder the sole abnormality, other than cholelithiasis, was an adenomyoma.
  • Other resected findings included five Meckel's diverticula, one bile duct adenoma, and one sigmoid diverticulum.
  • [MeSH-major] Appendectomy / methods. Cecal Diseases / diagnosis. Cholecystectomy / methods. Gallbladder Neoplasms / diagnosis. Gastric Bypass / methods. Incidental Findings. Stomach Diseases / diagnosis
  • [MeSH-minor] Adenomyoma / complications. Adenomyoma / diagnosis. Adenomyoma / surgery. Adolescent. Adult. Aged. Cholelithiasis / complications. Cholelithiasis / diagnosis. Cholelithiasis / surgery. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Obesity / complications. Obesity / surgery. Retrospective Studies. Young Adult

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  • (PMID = 18586563.001).
  • [ISSN] 1550-7289
  • [Journal-full-title] Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
  • [ISO-abbreviation] Surg Obes Relat Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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38. Iwaki K, Shibata K, Ohta M, Endo Y, Uchida H, Tominaga M, Okunaga R, Kai S, Kitano S: Adenomyomatous hyperplasia of the common bile duct: report of a case. Surg Today; 2008;38(1):85-9

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  • Adenomyomatous hyperplasia is most commonly found in the stomach, gallbladder, duodenum, and jejunum, while it is rarely found in the extrahepatic bile duct.
  • A 62-year-old woman was referred to our institution with a diagnosis of common bile duct (CBD) stenosis which had been detected by endoscopic retrograde cholangiopancreatography (ERCP).
  • When a diagnosis of adenomyomatous hyperplasia of the CBD is difficult to make both preoperatively and intraoperatively, then a radical surgical procedure, such as a pancreatoduodenectomy, may be an effective treatment alternative.
  • [MeSH-major] Adenoma / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Hyperplasia. Middle Aged. Pancreaticoduodenectomy / methods. Tomography, X-Ray Computed

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  • (PMID = 18085373.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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39. Fishman DS, Tarnasky PR, Patel SN, Raijman I: Management of pancreaticobiliary disease using a new intra-ductal endoscope: the Texas experience. World J Gastroenterol; 2009 Mar 21;15(11):1353-8
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  • Diagnosis of biliary strictures was modified in 20/29 and confirmed to be malignant in 10/23.
  • Of the modified patients, no diagnosis was available in 17.
  • [MeSH-major] Gallbladder Diseases / diagnosis. Pancreatic Diseases / diagnosis
  • [MeSH-minor] Adenoma / pathology. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / pathology. Bile Ducts / pathology. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / pathology. Choledocholithiasis / diagnosis. Endoscopy, Digestive System / instrumentation. Endoscopy, Digestive System / methods. Female. Gallstones / diagnosis. Gallstones / surgery. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Gallbladder Diseases.
  • MedlinePlus Health Information. consumer health - Pancreatic Diseases.
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  • (PMID = 19294765.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2658829
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40. Costamagna G, Familiari P, Iacopini F, Shah S, Marchese M: [State of the art in therapeutic biliary endoscopy]. Rev Gastroenterol Mex; 2005 Jul;70 Suppl 1:63-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Ultimos adelantos en endoscopia biliar terapéutica.
  • What should one do with the gallbladder after extraction of common bile duct stone?
  • [MeSH-minor] Adenoma / surgery. Adenoma / therapy. Ampulla of Vater. Animals. Bile Duct Diseases / therapy. Biliary Fistula / therapy. Cholestasis / diagnosis. Cholestasis / therapy. Clinical Trials as Topic. Common Bile Duct Neoplasms / surgery. Common Bile Duct Neoplasms / therapy. Disease Models, Animal. Dogs. Drainage. Follow-Up Studies. Gallstones / therapy. Humans. Lithotripsy. Liver Transplantation. Magnetic Resonance Imaging. Meta-Analysis as Topic. Prosthesis Implantation. Retrospective Studies. Sphincterotomy, Endoscopic. Time Factors

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  • (PMID = 17469411.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 218
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41. Matsusaki S, Maguchi H, Takahashi K, Katanuma A, Osanai M, Urata T, Fukasawa M, Tsuchiya T, Ichiya T, Kurita A, Ambo Y, Nakamura F: [Clinical features of acute acalculous cholecystits-nosocomial manner and community-acquired manner]. Nihon Shokakibyo Gakkai Zasshi; 2008 Dec;105(12):1749-57

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To clarify the clinical features of acute acalculous cholecystitis (AAC), we reviewed 113 cases of AAC experienced from January, 2000 to December, 2007 in regard to patient background, etiology, imaging diagnosis, treatment, and outcomes.
  • On the contrary, mechanical bile stasis caused 37 cases (32.7%), and all but one case developed in a community-acquired manner. mechanical bile stasis included 9 cases of biliary tract neoplasm (5, cystic duct cancer; 3, gallbladder cancer; 1, papillary adenoma).

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  • (PMID = 19057160.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
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42. Kondo S, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M, Furuse J, Saito H, Tsuyuguchi T, Yamamoto M, Kayahara M, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Hirano S, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japan Society of Clinical Oncology: Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment. J Hepatobiliary Pancreat Surg; 2008;15(1):41-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although hepatectomy and/or pancreaticoduodenectomy are preferable for the curative resection of bile duct cancer, extrahepatic bile duct resection alone is also considered in patients for whom it is judged that curative resection would be achieved after a strict diagnosis of its local extension.
  • For patients with suspected gallbladder cancer, laparoscopic cholecystectomy is not recommended, and open cholecystectomy should be performed as a rule.
  • When gallbladder cancer invading the subserosal layer or deeper has been detected after simple cholecystectomy, additional resection should be considered.
  • Prognostic factors after resection for gallbladder cancer include the depth of mural invasion; lymph node metastasis; extramural extension, especially into the hepatoduodenal ligament; perineural invasion; and the degree of curability.
  • Pancreaticoduodenectomy is indicated for ampullary carcinoma, and limited operation is also indicated for carcinoma in adenoma.

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  • (PMID = 18274843.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC2794356
  • [Investigator] Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
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43. Chang HJ, Oh SN, Park MY, Rha SE, Choi BG: Fraudulent retouching of digital radiographic images--a potential risk. Clin Radiol; 2010 Dec;65(12):967-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: Ten representative key images were selected of aortic dissection, hepatocellular carcinoma, renal cell carcinoma, colon cancer, liver metastasis, hepatic cyst, gallbladder stones, splenic artery aneurysm, adrenal adenoma, and stomach cancer from abdominal computed tomography (CT) imaging performed in 2008.
  • Radiologists were requested to make a diagnosis for the 10 images, and were then asked to identify possible retouched images.
  • None of the reviewers recognized that some images were retouched during diagnosis.
  • The rate of correct diagnosis was 90% (range 71.7-100%).
  • The time to diagnosis and the time to detection of the retouched images were 15 (14-17) and 6 (5-7) min, respectively.

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  • [Copyright] Copyright © 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 21070899.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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44. Konishi M, Kinoshita T, Nakagohri T, Takahashi S, Gotohda N, Ryu M: Pancreas-sparing duodenectomy for duodenal neoplasms including malignancies. Hepatogastroenterology; 2007 Apr-May;54(75):753-7
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODOLOGY: The present study investigated 16 patients who underwent PSD for duodenal neoplasms including adenoma, cancer, carcinoid and non-epithelial tumor.
  • Although 1 patient with gallbladder cancer died postoperatively due to the results of a concomitant operation, no postoperative deaths or re-operations related to PSD were encountered.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postoperative Complications / diagnosis. Treatment Outcome

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  • (PMID = 17591055.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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45. Nakayama Y, Inoue H, Hamada Y, Takeshita M, Iwasaki H, Maeshiro K, Iwanaga S, Tani H, Ryu S, Yasunami Y, Ikeda S: Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases. Am J Surg Pathol; 2005 May;29(5):607-16
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases.
  • The intraductal tubular adenoma (ITA), pyloric gland type, of the pancreas is an uncommon benign tumor, akin to the pyloric gland type adenoma of the gallbladder.
  • In 2 cases, the adjacent pancreas showed foci of intraductal papillary-mucinous adenoma.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Pancreatic Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
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  • (PMID = 15832084.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Mucins; 0 / SMAD4 protein, human; 0 / Smad4 Protein; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 9001-10-9 / Pepsinogen A
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46. Xu LN, Zou SQ, Wang JM: Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma. World J Gastroenterol; 2005 Jun 28;11(24):3719-23
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma.
  • AIM: To study the role of Fas and Fas ligand (FasL) in biological behaviors of gallbladder carcinoma, and their correlated action and mechanism in tumor escape.
  • METHODS: Streptavidin-biotin-peroxidase immunohistochemistry technique was used to study the expression of Fas and FasL protein in 26 gallbladder carcinoma tissues, 18 gallbladder adenoma tissues, 3 gallbladder dysplasia tissues and 20 chronic cholecystitis tissues.
  • Expression of both proteins and apoptosis of the tumor infiltrating lymphocytes in cancer tissues of primary foci was compared with clinicopathological features of gallbladder carcinoma.
  • RESULTS: The positive rates of Fas were not significantly different among carcinoma, adenoma, dysplasia and chronic cholecystitis.
  • The apoptotic index (AI) in carcinoma was significantly higher than that in adenoma (t' = 4.19, P<0.01) and chronic cholecystitis (t' = 8.06, P<0.01).
  • The confidence interval (CI) of infiltrating lymphocytes in adenoma, chronic cholecystitis, well-differentiated carcinoma and Nevin I-III carcinoma was very significantly lower than that in carcinoma (t' = 6.99, P<0.01), adenoma (t' = 3.66, P<0.01), poorly-differentiated carcinoma (t' = 5.31, P<0.01) and Nevin IV-V carcinoma (t' = 3.76, P<0.01), respectively.
  • Apoptosis of infiltrating lymphocytes was not discovered in adenoma and chronic cholecystitis.
  • CONCLUSION: FasL expressed in gallbladder carcinoma cells permits tumor cells to escape from immune surveillance of organism by inducing apoptosis in infiltrating lymphocytes of carcinoma tissues.
  • Up-regulation of FasL expression plays an important role in invasive depth, histological classification and metastasis of gallbladder carcinoma.
  • [MeSH-major] Adenoma / immunology. Antigens, CD95 / immunology. Gallbladder Neoplasms / immunology. Membrane Glycoproteins / immunology. Tumor Escape / physiology

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
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  • (PMID = 15968727.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / FASLG protein, human; 0 / Fas Ligand Protein; 0 / Membrane Glycoproteins
  • [Other-IDs] NLM/ PMC4316023
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47. Constantea N, Axente D, Micu B: A case of pyloric-type gallbladder adenoma. J Gastrointestin Liver Dis; 2008 Mar;17(1):116-7
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of pyloric-type gallbladder adenoma.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • [CommentIn] J Gastrointestin Liver Dis. 2008 Sep;17(3):251-3 [18836615.001]
  • (PMID = 18392262.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Romania
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