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1. Ouaïssi M, Sielezneff I, Alves A, Pirro N, Heyries L, Robitail S, Consentino B, Payan MJ, Valleur P, Panis Y, Sastre B: [Long term outcome following 26 surgical ampullectomies]. Ann Chir; 2006 May;131(5):322-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Résultat à long terme de 26 ampullectomies chirurgicales.
  • Ampullectomy is an alternative to PD for benign ampulloma or, in high-risk patients, for invasive carcinoma.
  • The aim of this study was to report early and long term results of surgical ampullectomy for presumed benign ampullomas.
  • RESULTS: Final pathological examination revealed 15 adenomas, 4 in situ adenocarcinomas, 2 endocrine tumors, and 5 other benign lesions.
  • Four patients died during follow-up (including 3 from initial disease).
  • CONCLUSION: Ampullectomy is a good alternative to PD in case of benign or non-invasive malignant ampullary lesion, including in selected cases of FAP.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adenoma / surgery. Adenomatous Polyposis Coli / surgery. Adult. Aged. Carcinoma in Situ / surgery. Cause of Death. Common Bile Duct Diseases / surgery. Female. Follow-Up Studies. Granuloma, Plasma Cell / surgery. Humans. Longitudinal Studies. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Retrospective Studies. Somatostatinoma / surgery. Survival Rate. Treatment Outcome

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  • (PMID = 16615931.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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2. Gardner-Thorpe J, Hardwick RH, Carroll NR, Gibbs P, Jamieson NV, Praseedom RK: Adult duodenal intussusception associated with congenital malrotation. World J Gastroenterol; 2007 Jul 28;13(28):3892-4
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  • In adults, there is usually an abnormality acting as a lead point, usually a Meckels' diverticulum, a hamartoma or a tumour.
  • Ultrasound scanning showed dilated bile and pancreatic ducts.
  • The lead point was an ampullary villous adenoma.
  • Congenital partial (type II) malrotation was found at operation and this abnormality permitted excessive mobility of the duodenal wall such that intussusception was possible.
  • [MeSH-major] Adenoma, Bile Duct / complications. Common Bile Duct Neoplasms / complications. Duodenal Obstruction / etiology. Duodenum / abnormalities. Intussusception / etiology

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  • (PMID = 17657849.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4611227
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3. Artifon EL, Sakai P, Baracat R, Moura EG: Endoscopic ampullectomy in a patient with a duodenal diverticulum. A challenging procedure. Rev Gastroenterol Mex; 2010;75(2):199-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Biopsy of the ampulla was positive for villous adenoma.
  • [MeSH-major] Adenoma, Villous / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Endoscopy, Digestive System

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  • (PMID = 20615792.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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4. Honda G, Kurata M, Matsumura H, Matsumoto H, Kamisawa T, Egawa N: Laparoscopy-assisted transduodenal papillectomy. Dig Surg; 2010;27(2):123-6
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  • BACKGROUND/AIMS: Basically, patients with cancer of the major duodenal papilla should undergo pylorus-preserving pancreatoduodenectomy; however, patients with adenoma or cancer in adenoma do not require prophylactic lymph node dissection, so they are indicated for limited resection of the major duodenal papilla.
  • Initially, kocherization was performed, followed by laparoscopic cholecystectomy, and a C-tube was placed in the common bile duct through the cystic duct.
  • After resection, the resection stumps of the bile duct and the pancreatic duct were sutured along with the duodenal mucosa.
  • RESULTS: We performed LATDP in 2 patients with cancer in adenoma.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Laparoscopy / methods. Pancreaticoduodenectomy / methods

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  • [Copyright] (c) 2010 S. Karger AG, Basel.
  • (PMID = 20551656.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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5. Tátrai P, Somorácz A, Batmunkh E, Schirmacher P, Kiss A, Schaff Z, Nagy P, Kovalszky I: Agrin and CD34 immunohistochemistry for the discrimination of benign versus malignant hepatocellular lesions. Am J Surg Pathol; 2009 Jun;33(6):874-85
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  • [Title] Agrin and CD34 immunohistochemistry for the discrimination of benign versus malignant hepatocellular lesions.
  • Agrin is a recently identified proteoglycan component of vascular and bile duct basement membranes in the liver.
  • We focused on the differential diagnostic problems often presented by hepatocellular adenomas (HCAs) and dysplastic nodules.
  • The majority of benign lesions were clearly agrin-negative, whereas the strength and extent of agrin IHC faithfully reflected dysplasia in "atypical" HCAs and in high-grade dysplastic nodules.
  • In conclusion, as agrin is highly selective for tumor blood vessels, IHC for agrin facilitates the discrimination of benign and malignant hepatocellular lesions.
  • [MeSH-major] Adenoma, Liver Cell / diagnosis. Agrin / biosynthesis. Antigens, CD34 / biosynthesis. Carcinoma, Hepatocellular / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 19194276.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Agrin; 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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6. Bellizzi AM, Kahaleh M, Stelow EB: The assessment of specimens procured by endoscopic ampullectomy. Am J Clin Pathol; 2009 Oct;132(4):506-13
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  • Previous biopsy diagnoses were compared with ampullectomy diagnoses, and histologic and clinical features were correlated with disease persistence.
  • The histologic features of the ampullectomy specimens were as follows: diagnosis (no diagnostic abnormality, 3; reactive, 8; adenoma, 26; adenocarcinoma, 7; other, 1); HGD, 1; submucosal ampullary gland/ductule involvement, 20; specimen integrity (intact, 22; fragmented, 23); and margin status (positive, 20; negative, 2; could not be assessed, 12).
  • Of the patients, 33 (73%) had documented persistent disease.
  • None of the histologic or clinical features had a statistically significant relationship with disease persistence.
  • [MeSH-major] Adenoma / pathology. Ampulla of Vater / pathology. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / pathology. Endoscopy

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  • (PMID = 19762527.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Aparajita R, Gomez D, Verbeke CS, Menon KV: Papillary adenoma of the distal common bile duct associated with a synchronous carcinoma of the peri-ampullary duodenum. JOP; 2008;9(2):212-5
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  • [Title] Papillary adenoma of the distal common bile duct associated with a synchronous carcinoma of the peri-ampullary duodenum.
  • CONTEXT: Benign tumours of the biliary tract are an extremely rare group of neoplasms.
  • Coincidence of a biliary adenoma of the distal common bile duct and a synchronous adenocarcinoma of the peri-ampullary duodenum has never been reported in the literature.
  • CASE REPORT: We report a case of a papillary adenoma in the common bile duct in a 75-year-old female, who had synchronous invasive adenocarcinoma of the peri-ampullary duodenum.
  • CONCLUSION: Isolated papillary adenoma of the bile duct is extremely rare, and in this unusual case it coincided with a peri-ampullary duodenal adenocarcinoma.
  • However, this is a rare instance of an incidental finding within the distal bile duct following pancreaticoduodenectomy for curative treatment of a peri-ampullary adenocarcinoma.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Common Bile Duct / pathology. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 18326932.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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8. Somorácz A, Tátrai P, Horváth G, Kiss A, Kupcsulik P, Kovalszky I, Schaff Z: Agrin immunohistochemistry facilitates the determination of primary versus metastatic origin of liver carcinomas. Hum Pathol; 2010 Sep;41(9):1310-9
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  • In our earlier work, we demonstrated that agrin, a multifunctional heparan sulfate proteoglycan, accumulates in hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC).
  • In addition, we proved the utility of agrin immumohistochemistry in discriminating between HCCs and benign parenchymal lesions.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Agrin / metabolism. Carcinoma, Hepatocellular / pathology. Colorectal Neoplasms / secondary. Liver Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Antigens, CD34 / metabolism. Bile Duct Neoplasms / genetics. Bile Duct Neoplasms / metabolism. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Carcinoma, Pancreatic Ductal / genetics. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Pancreatic Ductal / secondary. Cholangiocarcinoma / genetics. Cholangiocarcinoma / metabolism. Cholangiocarcinoma / pathology. DNA, Neoplasm / analysis. Diagnosis, Differential. Endothelium, Vascular / metabolism. Endothelium, Vascular / pathology. Female. Gene Expression Regulation, Neoplastic. Hepatectomy. Humans. Male. Microvessels / metabolism. Microvessels / pathology. Middle Aged. Pancreatic Neoplasms / genetics. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology. RNA, Messenger / metabolism. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20471664.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Agrin; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / RNA, Messenger
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9. Lee S, Kim YS, Lee WJ, Jang KT: Intraductal oncocytic papillary neoplasm of the bile duct: ultrasonography and CT findings with pathological correlations. Clin Radiol; 2009 Aug;64(8):841-4
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  • [Title] Intraductal oncocytic papillary neoplasm of the bile duct: ultrasonography and CT findings with pathological correlations.
  • [MeSH-major] Adenoma, Oxyphilic. Bile Duct Neoplasms. Carcinoma, Papillary
  • [MeSH-minor] Bile Ducts / ultrasonography. Cholangiography. Female. Humans. Male. Middle Aged

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  • (PMID = 19589423.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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10. Ramia Angel JM, Quiñones Sampedro JE, Veguillas Redondo P, Sabater Maroto C, Garcia-Parreño Jofré J: [Transduodenal ampullectomy as treatment of ampulla of Vater adenoma]. Cir Esp; 2010 Mar;87(3):184-5
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  • [Title] [Transduodenal ampullectomy as treatment of ampulla of Vater adenoma].
  • [Transliterated title] Ampulectomía transduodenal como tratamiento del adenoma de ampolla de Vater.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery

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  • (PMID = 19439277.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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11. Di Giorgio A, Alfieri S, Rotondi F, Prete F, Di Miceli D, Ridolfini MP, Rosa F, Covino M, Doglietto GB: Pancreatoduodenectomy for tumors of Vater's ampulla: report on 94 consecutive patients. World J Surg; 2005 Apr;29(4):513-8
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  • A total of 94 consecutive patients with ampullary carcinoma or adenoma with severe dysplasia were managed from 1981 to 2002.
  • Pancreatoduodenectomy is the treatment of choice for ampullary carcinoma and adenomas with high-grade dysplasia, with a good chance of long-term survival.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 15776300.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
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12. Swain JM, Adams RB, Farnell MB, Que FG, Sarr MG: Gastric and pancreatoduodenal resection for malignant lesions after previous gastric bypass--diagnosis and methods of reconstruction. Surg Obes Relat Dis; 2010 Nov-Dec;6(6):670-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma, Islet Cell / diagnosis. Adenoma, Islet Cell / epidemiology. Adenoma, Islet Cell / surgery. Aged. Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Neuroendocrine / epidemiology. Carcinoma, Neuroendocrine / surgery. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / epidemiology. Common Bile Duct Neoplasms / surgery. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • [Copyright] Copyright © 2010 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20627707.001).
  • [ISSN] 1878-7533
  • [Journal-full-title] Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
  • [ISO-abbreviation] Surg Obes Relat Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Khan SA, Toledano MB, Taylor-Robinson SD: Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma. HPB (Oxford); 2008;10(2):77-82
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  • Cholangiocarcinoma (CCA) is a fatal cancer of the biliary epithelium, arising either within the liver (intrahepatic, ICC) or in the extrahepatic bile ducts (extrahepatic ECC).
  • These include primary sclerosing cholangitis, liver fluke infestation, congenital fibropolycystic liver, bile duct adenomas, and biliary papillomatosis, hepatolithiasis, chemical carcinogens such as nitrosamines, Thorotrast, chronic viral hepatitis, cirrhosis, chronic non-alcoholic liver disease and obesity.

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  • (PMID = 18773060.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2504381
  • [Keywords] NOTNLM ; Cholangiocarcinoma
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14. Gheorghe C, Iacob R, Bancila I, Herlea V, Hrehoret D: Ampullary bleeding diagnosed using CCD high resolution and real time viewer capsule endoscope system. J Gastrointestin Liver Dis; 2007 Jun;16(2):187, 210
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / diagnosis. Ampulla of Vater. Capsule Endoscopes. Common Bile Duct Neoplasms / diagnosis. Gastrointestinal Hemorrhage / diagnosis

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  • (PMID = 17679170.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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15. Braun U, Nuss K, Soldati G, Ossent P: Clinical and ultrasonographic findings in four cows with liver tumours. Vet Rec; 2005 Oct 15;157(16):482-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Adenocarcinoma / veterinary. Adenoma, Liver Cell / pathology. Adenoma, Liver Cell / ultrasonography. Adenoma, Liver Cell / veterinary. Animals. Bile Duct Neoplasms / pathology. Bile Duct Neoplasms / ultrasonography. Bile Duct Neoplasms / veterinary. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / pathology. Carcinoma, Hepatocellular / ultrasonography. Carcinoma, Hepatocellular / veterinary. Cattle. Cholangiocarcinoma / pathology. Cholangiocarcinoma / ultrasonography. Cholangiocarcinoma / veterinary. Female. Liver / pathology. Liver / ultrasonography

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  • (PMID = 16227385.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies). Natl Toxicol Program Tech Rep Ser; 2006 Feb;(533):1-264
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  • Benzophenone is used as a photoinitiator, a fragrance enhancer, an ultraviolet curing agent, and occasionally as a flavor ingredient; it is also used in the manufacture of insecticides, agricultural chemicals, and hypnotics, antihistamines, and other pharmaceuticals; and it is used as an additive in plastics, coatings, and adhesive formulations.
  • There was a positive trend in the incidences of renal tubule adenoma in males, and the incidences in 625 and 1,250 ppm males exceeded the historical control range for all routes; these neoplasms were accompanied by significantly increased incidences of renal tubule hyperplasia.
  • Due to these findings, additional kidney sections were evaluated; results indicated additional renal tubule adenomas in all groups of males and renal tubule hyperplasia in all groups of males and females.
  • Liver lesions included significantly increased incidences of hepatocytic centrilobular hypertrophy in all exposed groups of males and females, cystic degeneration in 625 and 1,250 ppm males, and bile duct hyperplasia in all exposed groups of females.
  • In male mice, there were significantly increased incidences of hepatocellular adenoma in the 625 and 1,250 ppm groups, and these incidences exceeded the historical control range.
  • In female mice, the incidences of hepatocellular adenoma in the 625 and 1,250 ppm groups were higher than expected after adjusting for the lower body weights in these groups.
  • CONCLUSIONS: Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of benzophenone in male F344/N rats based on increased incidences of renal tubule adenoma; mononuclear cell leukemia in male F344/N rats may have been related to benzophenone exposure.
  • There was some evidence of carcinogenic activity of benzophenone in male B6C3F1 mice based on increased incidences of hepatocellular neoplasms, primarily adenoma.
  • There was some evidence of carcinogenic activity of benzophenone in female B6C3F1 mice based on increased incidences of histiocytic sarcoma; the incidences of hepatocellular adenoma in female B6C3F1 mice may have been related to benzophenone exposure.

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  • (PMID = 16741556.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzophenones; 0 / Photosensitizing Agents; 701M4TTV9O / benzophenone
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17. Suffat LP, Fronda G, Maglione V, Righi D, Doriguzzi A, Repici A, De Paolis P: Cholangioscopic management of intrahepatic papillomatosis unsuitable for surgical treatment. Ann Ital Chir; 2009 Jan-Feb;80(1):35-8
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  • Biliary papillomatosis grow according to the sequence adenoma-carcinoma with malignant transformation and poor prognosis due to multifocality and high recurrence rate.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Carcinoma, Papillary / surgery. Cholangiopancreatography, Endoscopic Retrograde / methods. Papilloma / surgery

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  • (PMID = 19537121.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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18. Munshi AG, Hassan MA: Common bile duct adenoma: case report and brief review of literature. Surg Laparosc Endosc Percutan Tech; 2010 Dec;20(6):e193-4
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  • [Title] Common bile duct adenoma: case report and brief review of literature.
  • Papillary adenomas of the common bile duct are a rare entity with few published case reports and limited knowledge on its natural progression.
  • We report here a case of common bile duct papillary adenoma in a 69-year-old female who presented with symptoms of common bile duct obstruction.
  • She was treated with local endoscopic excision of the mass that has benign features.
  • A brief review of literature is discussed with a proposed treatment plan for follow-up with surveillance endoscopy and ultrasonography as opposed to the radical resection for benign findings on pathology.
  • [MeSH-major] Adenoma / surgery. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde. Common Bile Duct / pathology. Common Bile Duct Diseases / diagnosis. Dilatation, Pathologic. Female. Humans. Sphincterotomy, Endoscopic

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  • (PMID = 21150400.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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19. Esaki M, Matsumoto T, Yao S, Nakamura S, Hirahashi M, Yao T, Iida M: Immunohistochemical characteristics of duodenal adenomas in familial adenomatous polyposis with special reference to cell kinetics. Hum Pathol; 2005 Jan;36(1):66-73
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  • [Title] Immunohistochemical characteristics of duodenal adenomas in familial adenomatous polyposis with special reference to cell kinetics.
  • The main objective of this study was to evaluate the cell kinetics in duodenal and ampullary adenomas in FAP.
  • The endoscopic and biopsy findings of duodenal adenomas in 22 FAP subjects and 18 non-FAP subjects were compared.
  • Adenomas in FAP included 15 ampullary adenomas and 17 nonampullary adenomas.
  • All 50 adenomas were histologically verified to be tubular adenoma with low-grade dysplasia.
  • In patients with FAP, duodenal adenoma tended to have a higher Ki-67-labeling index than the ampullary adenoma (54.3 +/- 11.3 versus 46.8 +/- 12.7; .05 < P < .1).
  • In addition, the Ki-67-labeling index in endoscopically normal or slightly enlarged ampullary adenoma was significantly higher than that in markedly enlarged ampullary adenoma (51.8 +/- 11.4 versus 39.4 +/- 11.3; P < .05).
  • Duodenal adenoma in FAP subjects was not found to have a higher proliferative activity or a smaller degree of apoptosis compared with those in non-FAP subjects.
  • The smaller proliferative activity in larger ampullary adenoma may thus be related to the static nature of ampullary adenoma in FAP.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Adenomatous Polyposis Coli / complications. Apoptosis / physiology. Duodenal Neoplasms / metabolism. Duodenal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Ampulla of Vater / metabolism. Ampulla of Vater / pathology. Cell Proliferation. Common Bile Duct Neoplasms / metabolism. Common Bile Duct Neoplasms / pathology. Cyclooxygenase 2. Female. Genes, APC. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Ki-67 Antigen / metabolism. Male. Membrane Proteins. Middle Aged. Mutation. Polymorphism, Single-Stranded Conformational. Prostaglandin-Endoperoxide Synthases / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 15712184.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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20. Otani K, Tohara K, Mihara K, Ueki T, Tanaka M, Sakaguchi S, Matsui T, Yao T, Haraoka S, Iwashita A: [A case of intrahepatic bile duct adenoma]. Nihon Shokakibyo Gakkai Zasshi; 2006 Jan;103(1):37-43
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  • [Title] [A case of intrahepatic bile duct adenoma].
  • [MeSH-major] Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic

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  • (PMID = 16444984.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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21. National Toxicology Program: Toxicology and carcinogenesis studies of a mixture of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (Cas No. 1746-01-6), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) (Cas No. 57117-31-4), and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) in female Harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser; 2006 Sep;(526):1-180
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  • Since human exposure to DLCs always involves a complex mixture, the toxic equivalency factor (TEF) methodology has been developed as a mathematical tool to assess the health risk posed by complex mixtures of these compounds.
  • At 53 weeks, there was a significant effect on the incidences of hepatocellular hypertrophy, multinucleated hepatocytes, pigmentation, focal fatty change, bile duct hyperplasia, and toxic hepatopathy.
  • At 2 years, there were significant increases in the incidences of hepatocellular adenoma and cholangiocarcinoma of the liver.
  • There was an increase in hepatic toxicity characterized by increases in the incidences of numerous nonneoplastic lesions including hepatocyte hypertrophy, multinucleated hepatocytes, pigmentation, inflammation, diffuse fatty change, bile duct hyperplasia, oval cell hyperplasia, nodular hyperplasia, eosinophilic focus, cholangiofibrosis, bile duct cysts, necrosis, portal fibrosis, mixed cell focus, and toxic hepatopathy.
  • In the pancreas, there were increases in the incidences of numerous nonneoplastic lesions including arterial chronic active inflammation, acinar cytoplasmic vacuolization, acinar atrophy, chronic active inflammation, and duct dilatation.
  • At 2 years, incidences of acinar adenoma or acinar carcinoma that exceeded the historical control ranges were seen in all dosed groups except the 100 ng TEQ/kg group.

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  • (PMID = 17342195.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzofurans; 0 / Carcinogens; DFC2HB4I0K / Polychlorinated Biphenyls; TSH69IA9XF / 3,4,5,3',4'-pentachlorobiphenyl; U4C2RV3124 / 2,3,4,7,8-pentachlorodibenzofuran
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22. Agaram NP, Shia J, Tang LH, Klimstra DS: DNA mismatch repair deficiency in ampullary carcinoma: a morphologic and immunohistochemical study of 54 cases. Am J Clin Pathol; 2010 May;133(5):772-80
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  • [Title] DNA mismatch repair deficiency in ampullary carcinoma: a morphologic and immunohistochemical study of 54 cases.
  • This study evaluated the MMR status in 54 consecutive ampullary adenocarcinomas by immunohistochemical and morphologic studies.
  • Five TILs per 10 high-power fields predicted immunohistochemical abnormality in 2 of 3 tumors with a specificity of 80% (41/51); however, none of the 5 tumors that had the highest TIL counts (20-62/10 high-power fields) showed abnormal immunohistochemical results.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. DNA Mismatch Repair / genetics. Nuclear Proteins

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  • (PMID = 20395525.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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23. Ogawa H, Itoh S, Ikeda M, Suzuki K, Naganawa S: Intraductal papillary mucinous neoplasm of the pancreas: assessment of the likelihood of invasiveness with multisection CT. Radiology; 2008 Sep;248(3):876-86
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  • Two radiologists blinded to the pathologic assessment of malignancy or parenchymal invasion of IPMN retrospectively evaluated CT images of 61 consecutive surgically resected tumors (26 adenomas, 15 noninvasive carcinomas, and 20 invasive carcinomas) in patients who underwent multiphase contrast material-enhanced CT with 0.5- or 1-mm collimation.
  • RESULTS: The following findings showed significant differences among the three groups: maximum diameter of the main pancreatic duct (MPD), size (length of major axis) of the largest mural nodule in the MPD or in any associated cystic lesion, abnormal attenuating area in the surrounding parenchyma, calcification in the lesion, protrusion of the MPD into the ampulla of Vater, and bile duct dilatation.
  • CONCLUSION: Multisection CT is useful for distinguishing among adenoma, noninvasive carcinoma, and invasive carcinoma in patients with IPMN.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiography. Adenoma / radiography. Pancreatic Neoplasms / radiography. Papilloma, Intraductal / radiography. Radiographic Image Enhancement / methods. Tomography, X-Ray Computed / methods

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  • [Copyright] RSNA, 2008
  • (PMID = 18632526.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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24. Riener MO, Stenner F, Liewen H, Soll C, Breitenstein S, Pestalozzi BC, Samaras P, Probst-Hensch N, Hellerbrand C, Müllhaupt B, Clavien PA, Bahra M, Neuhaus P, Wild P, Fritzsche F, Moch H, Jochum W, Kristiansen G: Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepatocellular carcinomas. Hepatology; 2009 May;49(5):1602-9
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  • [Title] Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepatocellular carcinomas.
  • Hepatocellular carcinomas (HCCs) and bile duct carcinomas (BDCs) have a poor prognosis.
  • Recently, Golgi Phosphoprotein 2 (GOLPH2) has been proposed as a serum marker for HCC, but GOLPH2 expression data in liver tissues was not available.
  • Using tissue microarrays and immunohistochemistry, we semiquantitatively analyzed GOLPH2 protein expression in patients with HCC (n = 170), benign liver tumors (n = 22), BDC (n = 114) and normal liver tissue (n = 105).
  • In patients with hepatitis C, serial ELISA measurements in the course of the disease appear to be a promising complementary serum marker in the surveillance of HCC.
  • GOLPH2 should be further evaluated as a serum tumor marker in BDC on a larger scale.
  • [MeSH-major] Adenoma, Liver Cell / metabolism. Bile Duct Neoplasms / metabolism. Carcinoma, Hepatocellular / metabolism. Focal Nodular Hyperplasia / metabolism. Liver Neoplasms / metabolism. Membrane Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bile Ducts / pathology. Biomarkers, Tumor / blood. Enzyme-Linked Immunosorbent Assay. Hepatitis, Chronic / blood. Humans. Middle Aged. Tissue Array Analysis. Young Adult

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  • [CommentIn] Hepatology. 2009 Jul;50(1):325 [19492428.001]
  • [CommentIn] Hepatology. 2009 Jul;50(1):326 [19496179.001]
  • [CommentIn] Hepatology. 2009 May;49(5):1421-3 [19402061.001]
  • [CommentIn] Hepatology. 2009 Nov;50(5):1682 [19739256.001]
  • (PMID = 19291786.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GOLM1 protein, human; 0 / Membrane Proteins
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25. Gray MN, Aylward LL, Keenan RE: Relative cancer potencies of selected dioxin-like compounds on a body-burden basis: comparison to current toxic equivalency factors (TEFs). J Toxicol Environ Health A; 2006 May;69(10):907-17
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  • Poly-3 adjusted tumor incidences for hepatocellular adenomas, cholangiocarcinomas, and the two tumors combined were modeled using a quantal multistage model and the Hill model with lifetime average body burden as the dose metric.
  • [MeSH-major] Adenoma, Liver Cell / chemically induced. Benzofurans / adverse effects. Cholangiocarcinoma / chemically induced. Digestive System Neoplasms / chemically induced. Polychlorinated Biphenyls / adverse effects. Tetrachlorodibenzodioxin / adverse effects
  • [MeSH-minor] Adipose Tissue / chemistry. Animals. Bile Duct Neoplasms / chemically induced. Bile Ducts, Intrahepatic. Body Burden. Carcinogenicity Tests. Humans. Liver / chemistry. Liver Neoplasms / chemically induced. Lung / chemistry. Models, Biological. Organ Size. Risk Assessment

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  • (PMID = 16728370.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzofurans; DFC2HB4I0K / Polychlorinated Biphenyls; DO80M48B6O / Tetrachlorodibenzodioxin; TSH69IA9XF / 3,4,5,3',4'-pentachlorobiphenyl; U4C2RV3124 / 2,3,4,7,8-pentachlorodibenzofuran
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26. Haas S, Gütgemann I, Wolff M, Fischer HP: Intrahepatic clear cell cholangiocarcinoma: immunohistochemical aspects in a very rare type of cholangiocarcinoma. Am J Surg Pathol; 2007 Jun;31(6):902-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell cholangiocarcinoma is a very unusual variant of peripheral bile duct carcinoma.
  • Positive expression of CK7 indicated a cholangiocellular origin.
  • Electronmicroscopy revealed only a few glycogen granula, but numerous cytoplasmic lipoid vacuoles as a possible explanation for the clear cell phenotype.
  • They also show CD56 expression which is a very uncommon finding for intrahepatic cholangiocarcinomas.
  • As CD56 expression is also found in reactive bile ducts and bile duct adenomas, one may speculate that these rare neoplasms may originate from reactive bile ducts or cholangiomatous lesions.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology

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  • (PMID = 17527078.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Keratin-7
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27. Boraschi P, Donati F, Volpi A, Pollina LE: Solitary hilar biliary adenoma: MR imaging and MR cholangiography features with pathologic correlation. Dig Liver Dis; 2007 Nov;39(11):1031-4
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  • [Title] Solitary hilar biliary adenoma: MR imaging and MR cholangiography features with pathologic correlation.
  • Biliary adenoma is a rare tumour characterized by the proliferation of bile duct epithelium into the lumen.
  • Diagnosis is usually based on the imaging findings of bile duct dilatation and intraductal mass.
  • We describe previously un-reported magnetic resonance imaging and magnetic resonance cholangiography features with endoscopic retrograde cholangiography and pathologic correlation of a solitary hilar biliary adenoma.
  • [MeSH-major] Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / pathology. Cholangiopancreatography, Magnetic Resonance. Magnetic Resonance Imaging

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  • (PMID = 17317343.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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28. Hohmann J, Loddenkemper C, Albrecht T: Assessment of a biliary hamartoma with contrast-enhanced sonography using two different contrast agents. Ultraschall Med; 2009 Apr;30(2):185-8
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  • Low-MI contrast-enhanced ultrasound (CEUS) with SonoVue (Bracco, Milano, Italy) showed an enhancement pattern which was typical for benign liver lesions while high-MI CEUS with Levovist (Schering, Berlin, Germany) revealed a contrast defect in the liver late phase (4:30 min p. i.) which is typical for a malignant lesion.
  • Due to these findings the lesion was evaluated as a potentially malignant lesion and a biopsy was performed.
  • Histology showed a benign biliary hamartoma and incomplete cirrhosis.
  • The findings confirmed that liver-specific contrast agents have the ability to detect very small focal liver lesions not derived from hepatic tissue but may lead to a misinterpretation as a malignant lesion.
  • Nevertheless biliary duct adenomas are benign lesions with almost the same perfusion properties as normal liver parenchyma.
  • [MeSH-major] Adenoma, Bile Duct / ultrasonography. Bile Duct Diseases / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Intrahepatic / ultrasonography. Contrast Media. Hamartoma / ultrasonography. Phospholipids. Polysaccharides. Sulfur Hexafluoride. Ultrasonography, Doppler, Duplex

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  • (PMID = 18726842.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / Polysaccharides; 0 / contrast agent BR1; 127279-08-7 / SHU 508; WS7LR3I1D6 / Sulfur Hexafluoride
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29. Genc H, Haciyanli M, Tavusbay C, Colakoglu O, Aksöz K, Unsal B, Ekinci N: Carcinoma arising from villous adenoma of the ampullary bile duct: Report of a case. Surg Today; 2007;37(2):165-8
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  • [Title] Carcinoma arising from villous adenoma of the ampullary bile duct: Report of a case.
  • Adenocarcinoma arising from the villous adenoma of the ampullary biliary epithelium is an extremely rare disorder.
  • The preoperative diagnosis and treatment of the disease represent a major difficulty.
  • Preoperative investigations revealed obstructive type jaundice due to a 2-cm mass at the end of common bile duct.
  • A frozen-section examination of these particles revealed villous adenoma.
  • The frozen-section examination of the resected material also revealed a villous adenoma.
  • The histological examination revealed a villous adenoma arising from the biliary epithelium and some adenocarcinoma foci.
  • This case shows the importance of surgeons to keep in mind the fact that frozen examinations may sometimes miss a malignancy and they therefore cannot be relied upon to rule out malignancy in villous adenoma of the ampullary bile duct.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Neoplasms, Multiple Primary

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  • [Cites] Arch Surg. 1996 Apr;131(4):366-71 [8615720.001]
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  • (PMID = 17243040.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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30. Hughes NR, Goodman ZD, Bhathal PS: An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. Am J Surg Pathol; 2010 Sep;34(9):1312-8
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  • [Title] An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis.
  • The so-called bile duct adenoma and peribiliary glands are characterized by the expression of two foregut antigens (designated D10 and 1F6) and secretion of acid mucin.
  • On account of this similarity in phenotype and their frequent close association with a large caliber bile duct, it was earlier suggested that bile duct adenoma represent a peribiliary gland hamartoma.
  • Here, we compare the expression of 13 tissue antigens in bile duct adenomas, other benign bile duct lesions, and various foregut-derived tissues, to further investigate the bile duct adenoma phenotype and pathogenesis.
  • Five foregut antigens (D10, 1F6, MUC6, MUC5AC, and TFF2) and secretion of acid mucin were of use in distinguishing bile duct adenoma from other hepatic lesions.
  • 1F6 and MUC6 were normally present in bile ductules and canals of Hering, whereas the epithelium lining the larger bile ducts stained focally for D10, MUC5AC, MUC6, or TFF2 in, respectively, 21%, 36%, 43%, and 100% of the livers examined.
  • Thirty-six bile duct adenomas examined were distinguished by expression of MUC6 (94% of bile duct adenoma), MUC5AC (90%), TFF2 (80%), D10 (67%), and 1F6 (61%), and varying degrees of acid mucin secretion (100%).
  • Of 30 bile duct adenoma tested for all 5 antigens, 40% expressed all 5, 27% expressed 4, 17% expressed 3, 13% expressed 2, and 1 expressed only MUC6.
  • The distinguishing feature of so-called bile duct adenoma is their display of the same phenotype as pyloric gland metaplasia.
  • It is concluded that they develop as a localized biliary healing response equivalent to the function of a peribiliary gland or pyloric gland metaplasia in the foregut.
  • [MeSH-major] Adenoma, Bile Duct / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology

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  • (PMID = 20679879.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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31. Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y: Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case. Surg Today; 2008;38(5):440-4
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  • [Title] Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case.
  • Upper endoscopy showed multiple duodenal adenomas including carcinoma involving the papilla of Vater.
  • To remove these duodenal adenomas and ampullary carcinoma and prevent recurrent pancreatitis, we performed pancreaticoduodenectomy.
  • On pathologic examination, the major duodenal papilla was completely obstructed by the carcinoma, and the minor papilla was also involved by the adenoma.
  • The patient has no evidence of disease and has experienced no pancreatitis in 3 years of follow-up.
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Adenomatous Polyposis Coli / complications. Ampulla of Vater. Common Bile Duct Neoplasms / etiology. Pancreatic Neoplasms / etiology. Pancreatitis / etiology


32. Lee TS, Kim HK, Ahn HM, Lee UJ, Choi YC, John BM, Park TI, Koo JH: [A case of early bile duct cancer arising from villous adenoma in choledochal cyst]. Korean J Gastroenterol; 2009 Jul;54(1):55-9
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  • [Title] [A case of early bile duct cancer arising from villous adenoma in choledochal cyst].
  • Herein, we report a rare case of bile duct adenoma arising from choledochal cyst with anomalous union of pancreaticobiliary duct (AUPBD).
  • She had received common bile duct (CBD) exploration and choledocholithotomy and cholecystectomy 3 months earlier under the diagnosis of multiple CBD stones.
  • On magnetic resonance cholangiopancreatography, the filling defect was confirmed as 2 cm polypoid mass attached to the distal bile duct wall.
  • On histological examination, adenoma with focal carcinoma change arising from choledochal cyst was diagnosed.
  • [MeSH-major] Adenoma, Villous / diagnosis. Bile Duct Neoplasms / diagnosis. Choledochal Cyst / diagnostic imaging

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  • (PMID = 19696552.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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33. Hornick JL, Lauwers GY, Odze RD: Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. Am J Surg Pathol; 2005 Mar;29(3):381-9
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  • [Title] Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver.
  • Not uncommonly, bile duct adenomas (BDAs) and hamartomas (BDHs) of the liver may be difficult to distinguish from metastatic well-differentiated ductal adenocarcinoma of the pancreas.
  • The slides were evaluated in a blinded fashion, and the results were compared between the benign and malignant lesions.
  • [MeSH-major] Adenocarcinoma / secondary. Adenoma / pathology. Bile Duct Neoplasms / pathology. Hamartoma / pathology. Liver Diseases / pathology. Pancreatic Neoplasms / pathology


34. Yamazaki S, Takayama T, Watanabe Y, Oikawa T, Hayashi Y, Kochi M, Moriguchi M, Higaki T, Inoue K: Imaging modality of three-dimensional CT in caudate cholangioma: assessment for resectability. Hepatogastroenterology; 2007 Mar;54(74):397-9
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  • [Title] Imaging modality of three-dimensional CT in caudate cholangioma: assessment for resectability.
  • Conventional preoperative imaging has limited modality and accuracy in primary intrahepatic cholangiocellular carcinoma (ICC) in the caudate lobe (CL).
  • His lesion was judged unresectable hilar cholangiocellular carcinoma because it had spread widely to the bilateral lobe of the liver as shown by preoperative imaging studies.
  • The left lobe showed marked atrophy and intrahepatic biliary duct (IHBD) dilatation of the whole liver was observed.
  • [MeSH-major] Bile Duct Neoplasms / radiography. Bile Ducts, Intrahepatic / radiography. Cholangiocarcinoma / radiography. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Tomography, Spiral Computed

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  • (PMID = 17523283.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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35. Fimmel CJ, Wright L: Golgi protein 73 as a biomarker of hepatocellular cancer: development of a quantitative serum assay and expression studies in hepatic and extrahepatic malignancies. Hepatology; 2009 May;49(5):1421-3
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  • [Title] Golgi protein 73 as a biomarker of hepatocellular cancer: development of a quantitative serum assay and expression studies in hepatic and extrahepatic malignancies.
  • [MeSH-minor] Adenoma, Liver Cell / metabolism. Bile Duct Neoplasms / metabolism. Focal Nodular Hyperplasia / metabolism. Humans

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  • [CommentOn] Hepatology. 2009 May;49(5):1602-9 [19291786.001]
  • [ErratumIn] Hepatology. 2009 Jul;50(1):331
  • (PMID = 19402061.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GOLM1 protein, human; 0 / Membrane Proteins
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36. Bohnacker S, Soehendra N, Maguchi H, Chung JB, Howell DA: Endoscopic resection of benign tumors of the papilla of vater. Endoscopy; 2006 May;38(5):521-5
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  • [Title] Endoscopic resection of benign tumors of the papilla of vater.
  • Most benign papillary tumors are adenomas which can potentially undergo the adenoma-carcinoma-sequence making complete removal mandatory for curative therapy.
  • Endoscopic resection (papillectomy) of these lesions is being increasingly performed as a less traumatic alternative to surgery.
  • Endoscopic snare resection of entire lesions should be primarily regarded as a diagnostic procedure.
  • For benign looking papillary tumors, endoscopic papillectomy serves as a diagnostic tool and should be considered as first line procedure regardless of age.
  • The following article details the approach to patients with benign papillary tumor and the technique of endoscopic papillectomy.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / surgery. Sphincterotomy, Endoscopic / methods

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  • (PMID = 16767591.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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37. Miyazaki M, Takada T, Miyakawa S, Tsukada K, Nagino M, Kondo S, Furuse J, Saito H, Tsuyuguchi T, Chijiiwa K, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Pancreatic Surgery, Japan Society of Clinical Oncology: Risk factors for biliary tract and ampullary carcinomas and prophylactic surgery for these factors. J Hepatobiliary Pancreat Surg; 2008;15(1):15-24
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  • It has been reported that pancreaticobiliary maljunction (PBM) with bile duct dilatation is a risk factor for gallbladder cancer and bile duct cancer, while PBM without bile duct dilatation is a risk factor for gallbladder cancer.
  • Thus, in the former group, a prophylactic excision of the common bile duct and gallbladder should be recommended, while in the later group, a prophylactic cholecystectomy without bile duct resection may be the appropriate surgical procedure.
  • Adenoma and dysplasia have been regarded as precancerous lesions of gallbladder cancer.
  • With respect to ampullary carcinoma, adenoma of the ampulla is considered to be a precancerous lesion.

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  • (PMID = 18274840.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Number-of-references] 39
  • [Other-IDs] NLM/ PMC2794357
  • [Investigator] Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
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38. Lim JH, Jang KT, Choi D: Biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the hepatic lobar or segmental bile ducts: imaging features in six patients. AJR Am J Roentgenol; 2008 Sep;191(3):778-82
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  • [Title] Biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the hepatic lobar or segmental bile ducts: imaging features in six patients.
  • OBJECTIVE: The purpose of this study was to evaluate the imaging features of intrahepatic biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the lobar or segmental bile ducts without a visible mass to determine whether this type of cholangiocarcinoma can be recognized on the basis of distinct imaging features.
  • Severe dilatation of the lobar or segmental intrahepatic bile ducts with crowding and severe atrophy of the hepatic parenchyma are helpful imaging findings.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiography. Adenoma / radiography. Bile Duct Neoplasms / radiography. Liver Diseases / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 18716109.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Demaret S, Lamfichekh N: [One train may hide another...]. J Chir (Paris); 2008 Mar-Apr;145(2):174-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Villous / diagnosis. Common Bile Duct Neoplasms / diagnosis

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  • (PMID = 18645562.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Clinical Conference; Journal Article
  • [Publication-country] France
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40. Ito K, Fujita N, Noda Y, Kobayashi G, Horaguchi J, Takasawa O, Obana T: Preoperative evaluation of ampullary neoplasm with EUS and transpapillary intraductal US: a prospective and histopathologically controlled study. Gastrointest Endosc; 2007 Oct;66(4):740-7
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  • Ductal infiltration by a tumor into the bile duct (BD) or the pancreatic duct (PD) was also evaluated.
  • MAIN OUTCOME MEASUREMENTS AND RESULTS: Thirty-three patients had adenocarcinoma (14 pT1, 11 pT2, 8 pT3-4) and 7 had adenoma.
  • The diagnostic accuracy of EUS and IDUS in T staging was 62% and 86% in adenoma and pT1, 45% and 64% in pT2, and 88% and 75% in pT3-4, respectively.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms. Duodenoscopy / methods. Endosonography / methods. Preoperative Care / methods. Sphincterotomy, Endoscopic / methods
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenocarcinoma / ultrasonography. Adenoma / pathology. Adenoma / surgery. Adenoma / ultrasonography. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Reproducibility of Results

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  • (PMID = 17905017.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
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41. Evert M, Schildhaus HU, Schneider-Stock R, Dombrowski F: Cystic cholangiomas after transplantation of pancreatic islets into the livers of diabetic rats. Virchows Arch; 2006 Jun;448(6):776-87
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  • [Title] Cystic cholangiomas after transplantation of pancreatic islets into the livers of diabetic rats.
  • Islet transplantation is increasingly used as a therapy for human type 1 diabetes mellitus.
  • In our study, we investigated the effect of the transplantation of a low number (n = 350) of pancreatic islets into the right liver part on the neighboring portal bile ducts.
  • During the next 12-24 months, many peri-insular ductules progressed via tumor-like cystic lesions to large cystic cholangiomas, accompanied by a translocation of the insulin receptor into the cytoplasm and an increase in expression of insulin-related signaling proteins (Insulin-receptor-substrate-1, Raf-1, Mek-1).
  • After 24 months, 53% of rats with low-number transplantation exhibited at least one cholangioma >10 mm, significantly outnumbering tumor development in the transplant-free left liver part and in any control group.
  • Conclusively, low-number intrahepatic islet transplantation, most likely acting by permanent local hyperinsulinism, leads to prolonged cholangiocellular proliferation in streptozotocin- and in autoimmune-diabetic rats, resulting in the development of benign cystic cholangiomas.
  • [MeSH-major] Adenoma, Bile Duct / etiology. Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic / pathology. Diabetes Mellitus, Experimental / complications. Diabetes Mellitus, Type 1 / complications. Islets of Langerhans Transplantation / adverse effects


42. Kim JH, Moon JH, Choi HJ, Lee HS, Kim HK, Cheon YK, Cho YD, Lee JS, Lee MS, Shim CS: Endoscopic snare papillectomy by using a balloon catheter for an unexposed ampullary adenoma with intraductal extension (with videos). Gastrointest Endosc; 2009 Jun;69(7):1404-6
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  • [Title] Endoscopic snare papillectomy by using a balloon catheter for an unexposed ampullary adenoma with intraductal extension (with videos).
  • [MeSH-major] Adenoma / therapy. Ampulla of Vater. Common Bile Duct Neoplasms / therapy

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  • (PMID = 19152886.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Nagano Y, Sekido H, Matsuoi K, Ohtsuki K, Gorai K, Kunisaki C, Ike H, Imada T, Shimada H: Successful pancreatoduodenectomy for carcinoma of the ampulla of vater after esophagectomy with remnant gastrectomy. Hepatogastroenterology; 2005 May-Jun;52(63):933-5
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  • In his past history, he had undergone distal gastrectomy for a gastric adenoma 17 years before.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Esophageal Neoplasms / surgery. Esophagectomy. Gastrectomy. Gastric Stump / surgery. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy. Postoperative Complications / surgery
  • [MeSH-minor] Adenoma / surgery. Humans. Lymph Node Excision. Middle Aged. Neoplasm Invasiveness. Reoperation. Stomach Neoplasms / surgery

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  • (PMID = 15966235.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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44. Uchiyama S, Chijiiwa K, Imamura N, Hiyoshi M, Ohuchida J, Nagano M, Nagaike K, Takahashi N, Akiyama Y: Adenoma of the major duodenal papilla with intraductal extension into the lower common bile duct. J Gastrointest Surg; 2008 Jun;12(6):1146-8
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  • [Title] Adenoma of the major duodenal papilla with intraductal extension into the lower common bile duct.
  • Although benign and malignant tumors of the major duodenal papilla can be detected endoscopically, definitive diagnosis of such lesions by histologic examination of biopsy specimens is sometimes difficult, especially in cases with intraductal extension into the bile duct or pancreatic duct.
  • We herein report a case of adenoma of the major duodenal papilla showing an intraductal extension into the lower common bile duct that necessitated pylorus-preserving pancreaticoduodenectomy.
  • [MeSH-major] Adenoma / pathology. Ampulla of Vater. Common Bile Duct / pathology. Duodenal Neoplasms / pathology. Neoplasm Invasiveness. Pancreaticoduodenectomy / methods

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  • [Cites] Surgery. 2004 Nov;136(5):994-1002 [15523392.001]
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  • (PMID = 17896165.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. National Toxicology Program: Toxicology and carcinogenesis studies of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) (Cas No. 57117-31-4) in female Harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser; 2006 Sep;(525):1-198
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  • Since human exposure to DLCs always involves a complex mixture, the toxic equivalency factor (TEF) methodology has been developed as a mathematical tool to assess the health risk posed by complex mixtures of these compounds.
  • PeCDF was selected for study by the National Toxicology Program as a part of the dioxin TEF evaluation to assess the cancer risk posed by complex mixtures of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCBs.
  • At 2 years, there were significant dose-dependent trends for increased incidences of hepatocellular adenoma and cholangiocarcinoma of the liver.
  • A significant dose-dependent increase in hepatic toxicity was observed and was characterized by increased incidences of numerous nonneoplastic lesions including hepatocellular hypertrophy, multinucleated hepatocytes, oval cell hyperplasia, diffuse fatty change, pigmentation, nodular hyperplasia, eosinophilic foci, hepatocellular necrosis, bile duct hyperplasia, bile duct fibrosis, cholangiofibrosis, and toxic hepatopathy.
  • One pancreatic acinar adenoma and one pancreatic acinar carcinoma were each observed in the 92 ng/kg group and in the 200 ng/kg stop-exposure group at 2 years.

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  • (PMID = 17160103.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzofurans; 0 / Carcinogens; 0 / Thyroid Hormones; U4C2RV3124 / 2,3,4,7,8-pentachlorodibenzofuran
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46. National Toxicology Program: NTP technical report on the toxicology and carcinogenesis studies of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (Gavage studies). Natl Toxicol Program Tech Rep Ser; 2006 May;(529):4-168
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  • Since human exposure to DLCs always involves a complex mixture, the toxic equivalency factor (TEF) methodology has been developed as a mathematical tool to assess the health risk posed by complex mixtures of these compounds.
  • 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) was produced as a component of some commercial PCB mixtures before 1977 for the electric industry as a dielectric insulating fluid for transformers and capacitors.
  • PCB 153 was selected for study by the National Toxicology Program as a part of the dioxin TEF evaluation to assess the cancer risk posed by complex mixtures of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs).
  • The incidences of diffuse fatty change in the 300 microg/kg or greater groups and bile duct hyperplasia of the liver in 300 microg/kg and 3,000 microg/kg (core and stop-exposure) groups were significantly increased.
  • At 2 years, two cholangiomas were seen in the 1,000 microg/kg group and two cholangiomas were seen in the 3,000 microg/kg stop-exposure group.
  • A single hepatocellular adenoma was observed in the 3,000 microg/kg core study group.
  • CONCLUSIONS: Under the conditions of this 2-year gavage study there was equivocal evidence of carcinogenic activity of PCB 153 in female Harlan Sprague-Dawley rats based on the occurrences of cholangioma of the liver.
  • [MeSH-major] Bile Ducts, Intrahepatic / pathology. Carcinogens / toxicity. Polychlorinated Biphenyls / toxicity
  • [MeSH-minor] Adenoma, Bile Duct / chemically induced. Adenoma, Bile Duct / pathology. Administration, Oral. Animals. Bile Duct Neoplasms / chemically induced. Bile Duct Neoplasms / pathology. Cell Enlargement / drug effects. Cell Proliferation / drug effects. Dose-Response Relationship, Drug. Female. Hepatocytes / drug effects. Hepatocytes / pathology. Liver / drug effects. Liver / pathology. Organ Size / drug effects. Rats. Rats, Sprague-Dawley. Thyroid Hormones / blood. Toxicity Tests

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  • (PMID = 16835634.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Thyroid Hormones; DFC2HB4I0K / Polychlorinated Biphenyls; ZRU0C9E32O / 2,4,5,2',4',5'-hexachlorobiphenyl
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47. National Toxicology Program: NTP toxicology and carcinogenesis studies of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) in female Harlan Sprague-Dawley rats (Gavage Studies). Natl Toxicol Program Tech Rep Ser; 2006 Jan;(520):4-246
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Since human exposure to DLCs always occurs as a complex mixture, the Toxic Equivalency Factor (TEF) methodology has been developed as a mathematical tool to assess the health risk posed by complex mixtures of these compounds.
  • 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) was produced commercially before 1977 for the electric industry as a dielectric insulating fluid for transformers and capacitors.
  • PCB 126 was selected for study by the National Toxicology Program as a part of the dioxin TEF evaluation to assess the cancer risk posed by complex mixtures of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCBs.
  • At 2 years, there were significant treatment-related increases in the incidences of cholangiocarcinoma and hepatocellular adenoma.
  • Three hepatocholangiomas were seen in the 1,000 ng/kg core study group and a single incidence of cholangioma each occurred in the 550 and 1,000 ng/kg core study groups.
  • At 2 years, a significant dose-related increase in hepatic toxicity was observed and was characterized by increased incidences of numerous lesions including hepatocyte hypertrophy, multinucleated hepatocytes, diffuse fatty change, bile duct hyperplasia, bile duct cyst, oval cell hyperplasia, necrosis, pigmentation, inflammation, nodular hyperplasia, portal fibrosis, cholangiofibrosis, and toxic hepatopathy.
  • At 2 years, adenomas and/or carcinomas were present in the adrenal cortex of most core study groups and in the 1,000 ng/kg stop-exposure group.

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  • (PMID = 16628245.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Thyroid Hormones; DFC2HB4I0K / Polychlorinated Biphenyls; TSH69IA9XF / 3,4,5,3',4'-pentachlorobiphenyl
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48. Small AJ, Baron TH: Successful endoscopic resection of ampullary adenoma with intraductal extension and invasive carcinoma (with video). Gastrointest Endosc; 2006 Jul;64(1):148-51
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  • [Title] Successful endoscopic resection of ampullary adenoma with intraductal extension and invasive carcinoma (with video).
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma / surgery. Ampulla of Vater. Cholangiopancreatography, Endoscopic Retrograde. Common Bile Duct Neoplasms / surgery

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  • (PMID = 16813830.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Kobuke T, Tazuma S, Hyogo H, Chayama K: A Ligand for peroxisome proliferator-activated receptor gamma inhibits human cholangiocarcinoma cell growth: potential molecular targeting strategy for cholangioma. Dig Dis Sci; 2006 Sep;51(9):1650-7
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  • [Title] A Ligand for peroxisome proliferator-activated receptor gamma inhibits human cholangiocarcinoma cell growth: potential molecular targeting strategy for cholangioma.
  • PPAR( expression in HuH-28 and HuCCT1 cells (intrahepatic bile duct carcinoma) was determined using the reverse transcription-polymerase chain reaction (RT-PCR).
  • [MeSH-minor] Bile Duct Neoplasms / enzymology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / enzymology. Bile Ducts, Intrahepatic / pathology. Caspase 3. Caspase 9. Caspases / metabolism. Cell Culture Techniques. Cell Line, Tumor. Cell Proliferation / drug effects. Humans. Ligands. Molecular Biology. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16927143.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Chromans; 0 / Ligands; 0 / PPAR gamma; 0 / RNA, Neoplasm; 0 / Thiazolidinediones; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / CASP9 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 9; EC 3.4.22.- / Caspases; I66ZZ0ZN0E / troglitazone; X4OV71U42S / pioglitazone
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50. Eswaran SL, Sanders M, Bernadino KP, Ansari A, Lawrence C, Stefan A, Mattia A, Howell DA: Success and complications of endoscopic removal of giant duodenal and ampullary polyps: a comparative series. Gastrointest Endosc; 2006 Dec;64(6):925-32
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  • BACKGROUND: Increasing reports suggest that endoscopic removal of benign ampullary and duodenal polyps is safe and frequently definitive; however, most reported polyps have been small in size (<3 cm).
  • When the ampulla was involved, biductal sphincterotomy and prophylactic pancreatic duct stent placement was performed first, followed by saline solution-assisted piecemeal polypectomy, argon plasma coagulation, selective endoclip placement, and recovery of all polyp fragments.
  • INTERVENTIONS: Endoscopic removal of duodenal and ampullary adenomas.
  • RESULTS: The outcomes of small and large adenoma removal include mean number of endoscopic retrograde cholangiopancreatographies required for complete removal (2.09 vs 2.56, P = .392), number of complications (4.5% vs 13.9%, P = .375), discovery of unsuspected cancer (0% vs 10.3%, P = .242), and final definitive resolution (100% vs 86.2%, P = .124).
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery. Endoscopy, Digestive System / methods. Polyps / surgery

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  • (PMID = 17140900.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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51. Wang L, Camus AC, Dong W, Thornton C, Willett KL: Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis. Aquat Toxicol; 2010 Sep 15;99(4):439-47
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  • Histopathologic findings included foci of cellular alteration and neoplasms, including hepatocellular adenoma, hepatocellular carcinoma and cholangioma.
  • In contrast, CYP1C1 was only detectable and highly expressed in proliferated bile duct epithelial cells.

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  • Hazardous Substances Data Bank. Benzo(a)pyrene .
  • Hazardous Substances Data Bank. 7,12-DIMETHYLBENZ(A)ANTHRACENE .
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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
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  • (PMID = 20621368.001).
  • [ISSN] 1879-1514
  • [Journal-full-title] Aquatic toxicology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Aquat. Toxicol.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES012710-05S1; United States / NIEHS NIH HHS / ES / R01 ES012710; United States / NIEHS NIH HHS / ES / R01 ES012710-05S1; United States / NIEHS NIH HHS / ES / R01ES012710
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 3417WMA06D / Benzo(a)pyrene; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; YOW8V9698H / Dimethyl Sulfoxide
  • [Other-IDs] NLM/ NIHMS222714; NLM/ PMC2924930
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52. Okada K, Furuuchi T, Tamada T, Sasaki T, Suwa T, Shatari T, Takenaka Y, Hori M, Sakuma M: Pancreatobiliary fistula associated with an intraductal papillary-mucinous pancreatic neoplasm manifesting as obstructive jaundice: report of a case. Surg Today; 2008;38(4):371-6
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  • Computed tomography showed dilatation of the bile duct and main pancreatic duct, with multiple cystic masses in the head of the pancreas.
  • Contrast enhancement outlined amorphous material obstructing the lower part of the common hepatic duct.
  • Pancreatogram and magnetic resonance cholangiopancreatography showed diffuse dilatation of the main pancreatic duct and side branches without communication with the adjacent organs or duct.
  • We performed pancreaticoduodenectomy for IPMN of the pancreatic head and a tumor-like lesion in the lower common bile duct (CBD).
  • Histologic examination revealed a pancreatobiliary fistula caused by intraductal papillary-mucinous carcinoma of the pancreas with mucin hypersecretion, an adenoma without interstitial infiltration, and isolated implantation of an IPMN in the bile duct mucosa around the fistula.

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  • (PMID = 18368332.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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53. Legler M, Kothe R, Rautenschlein S, Kummerfeld N: [Detection of psittacid herpesvirus 1 in Amazon parrots with cloacal papilloma (internal papillomatosis of parrots, IPP) in an aviary of different psittacine species]. Dtsch Tierarztl Wochenschr; 2008 Dec;115(12):461-70
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  • Hepatomegaly was detected in the radiographs of the clinically diseased amazon parrots, indicating the involvement of the liver in the disease process.
  • One of the amazons had an increased level of bile acids in the plasma supporting the suspicion of the involvement of the liver.
  • Macroscopical and histological investigation of amazons with cloacal prolaps revealed a papillomic adenoma of the cloacal mucosa accompanied by varying degrees of bile duct carcinomas in the liver and adenocarcinomas of the pancreas.
  • We may speculate that there is correlation between the infection with PsHV-1 and the development of cloacal adenomas, adenocarcinomas in the pancreas and carcinomas of the bile ducts.
  • A therapy approach with the immunomodulator Imiquimod did not improve the clinical disease of the birds, although circulating interferon levels were detected in serum samples of treated birds.

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  • (PMID = 19113029.001).
  • [ISSN] 0341-6593
  • [Journal-full-title] DTW. Deutsche tierärztliche Wochenschrift
  • [ISO-abbreviation] DTW. Dtsch. Tierarztl. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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54. Foo FJ, Gill U, Verbeke CS, Guthrie JA, Menon KV: Ampullary carcinoma associated with an annular pancreas. JOP; 2007;8(1):50-4
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  • CONTEXT: Annular pancreas is an uncommon congenital abnormality.
  • [MeSH-major] Adenoma / complications. Common Bile Duct Neoplasms / complications. Pancreas / abnormalities

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  • (PMID = 17228134.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 21
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55. Iwaki K, Shibata K, Ohta M, Endo Y, Uchida H, Tominaga M, Okunaga R, Kai S, Kitano S: Adenomyomatous hyperplasia of the common bile duct: report of a case. Surg Today; 2008;38(1):85-9
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  • [Title] Adenomyomatous hyperplasia of the common bile duct: report of a case.
  • Adenomyomatous hyperplasia is most commonly found in the stomach, gallbladder, duodenum, and jejunum, while it is rarely found in the extrahepatic bile duct.
  • A 62-year-old woman was referred to our institution with a diagnosis of common bile duct (CBD) stenosis which had been detected by endoscopic retrograde cholangiopancreatography (ERCP).
  • ERCP revealed a 15-mm-long stenosis of the lower CBD, but no malignant cells were detected by either bile cytology or brush cytology.
  • When a diagnosis of adenomyomatous hyperplasia of the CBD is difficult to make both preoperatively and intraoperatively, then a radical surgical procedure, such as a pancreatoduodenectomy, may be an effective treatment alternative.
  • [MeSH-major] Adenoma / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 18085373.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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56. Babich JP, Bonasera RJ, Klein J, Friedel DM: Pancreatic ascites: complication after endoscopic ultrasound-guided fine needle aspiration of a pancreatic cyst. Endoscopy; 2009;41 Suppl 2:E211-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma, Villous / pathology. Aged. Ampulla of Vater. Biopsy, Fine-Needle. Common Bile Duct Neoplasms / pathology. Drainage. Endosonography. Female. Humans. Pancreatic Diseases / etiology. Pancreatic Diseases / radiography. Pancreatic Diseases / surgery. Tomography, X-Ray Computed

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  • (PMID = 19637134.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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57. Wiedmann M, Schoppmeyer K, Witzigmann H, Hauss J, Mössner J, Caca K: [Current diagnostics and therapy for carcinomas of the biliary tree and gallbladder]. Z Gastroenterol; 2005 Mar;43(3):305-15
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  • Transformation of normal into malignant bile duct tissue requires a chain of consecutive gene mutations, similar to the adenoma-dysplasia-carcinoma-sequence in colon cancer.
  • For palliation, bile duct stenting and photodynamic therapy are established methods.
  • [MeSH-major] Bile Duct Neoplasms. Gallbladder Neoplasms
  • [MeSH-minor] Algorithms. Ampulla of Vater. Bile Ducts / pathology. Bile Ducts, Intrahepatic. Biopsy. Brachytherapy. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / therapy. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / therapy. Cyclooxygenase Inhibitors / therapeutic use. Gallbladder / pathology. Hepatectomy. Hepatic Duct, Common. Humans. Klatskin Tumor / diagnosis. Klatskin Tumor / therapy. Magnetic Resonance Imaging. Neoplasm Staging. Palliative Care. Retrospective Studies. Risk Factors. Stents. Time Factors

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  • [CommentIn] Z Gastroenterol. 2005 May;43(5):473-5 [15871071.001]
  • (PMID = 15765304.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors
  • [Number-of-references] 153
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58. Xu HX, Chen LD: Villous adenoma of extrahepatic bile duct: contrast-enhanced sonography findings. J Clin Ultrasound; 2008 Jan;36(1):39-41
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  • [Title] Villous adenoma of extrahepatic bile duct: contrast-enhanced sonography findings.
  • We report a case of villous adenoma in the extrahepatic bile duct that was successfully diagnosed with contrast-enhanced sonography (CEUS) before surgical resection.
  • On baseline sonography, the mass appeared as a homogeneously isoechoic mass filling the bile duct from the confluence of the right and left hepatic ducts to the distal common bile duct.
  • Surgical resection was performed, and pathologic examination confirmed a villous adenoma of the bile duct epithelium with mild dysplasia.
  • [MeSH-major] Adenoma, Villous / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Extrahepatic / ultrasonography

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc.
  • (PMID = 17565756.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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59. Morris-Stiff GJ, Senda Y, Verbeke CS, Lodge PA: Papillary adenoma arising in the left hepatic duct: an unusual tumour in an uncommon location. Eur J Gastroenterol Hepatol; 2010 Jul;22(7):886-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary adenoma arising in the left hepatic duct: an unusual tumour in an uncommon location.
  • Bile duct adenomas are rare tumours that arise more frequently in the distal extrahepatic biliary tree.
  • We report the case of a papillary adenoma arising at the junction of the common and left hepatic ducts and review the available literature on this rare entity.
  • Histological evaluation of the resected specimen confirmed a papillary adenoma with mild dysplasia.
  • [MeSH-major] Adenoma / diagnosis. Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic

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  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for papillary adenoma .
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  • (PMID = 20545030.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.3.2.2 / gamma-Glutamyltransferase
  • [Number-of-references] 10
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60. Beger HG, Rau BM, Gansauge F, Schwarz M, Siech M, Poch B: Duodenum-preserving total pancreatic head resection for cystic neoplasm: a limited but cancer-preventive procedure. Langenbecks Arch Surg; 2008 Jul;393(4):589-98
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  • For cystic neoplasia located monocentrically in the pancreatic head and that do not have an association with an invasive pancreatic cancer, the duodenum-preserving total head resection has been used in recent time as a limited surgical procedure.
  • PATIENTS: An indication to duodenum-preserving total pancreatic head resection is considered for patients who do not have clinical signs of an advanced cancer in the lesion and who have main-duct IPMN and monocentric MCN lesions.
  • The long-term outcome is determined by completeness of resection for both -- benign and malignant -- entities.
  • Absence of an advanced pancreatic cancer and completeness of extirpation of the benign tumor determine the long-term outcome.
  • [MeSH-major] Adenoma / surgery. Carcinoma, Pancreatic Ductal / surgery. Cystadenocarcinoma, Mucinous / surgery. Duodenum / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Cell Transformation, Neoplastic / pathology. Common Bile Duct / surgery. Frozen Sections. Humans. Neoplasm Invasiveness. Pancreas / pathology. Prognosis. Suture Techniques. Tomography, X-Ray Computed

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  • (PMID = 18379818.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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61. Kim YS, Rha SE, Oh SN, Jung SE, Shin YR, Choi BG, Byun JY, Jung ES, Kim DG: Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review. Korean J Radiol; 2010 Sep-Oct;11(5):560-5
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  • [Title] Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review.
  • Intrahepatic bile duct adenoma is a rare benign epithelial hepatic tumor derived from bile duct cells.
  • We report the imaging findings of a patient with bile duct adenoma, which appeared as a small heterogeneously enhancing mass with focal small cystic change on CT and MRI.
  • Although rare, bile duct adenoma should be considered as a differential diagnosis of a small hypervascular tumor located in the periphery of liver.
  • [MeSH-major] Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Hamartoma / diagnosis

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  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for bile duct adenoma .
  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for intrahepatic bile duct adenoma .
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  • [Journal-full-title] Korean journal of radiology
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  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ PMC2930166
  • [Keywords] NOTNLM ; Adenoma / Bile duct / Computed tomography (CT) / Liver / Magnetic resonance (MR)
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62. Wu DS, Chen WX, Wang XP: Ectopic pancreaticobiliary drainage accompanied by proximal jejunal adenoma: a case report. World J Gastroenterol; 2009 Sep 21;15(35):4467-70
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  • [Title] Ectopic pancreaticobiliary drainage accompanied by proximal jejunal adenoma: a case report.
  • A patient with obstructive jaundice was examined by multidetector row helical computed tomography (MDCT) and magnetic resonance imaging (MRI), and his common bile duct was observed to be leading into the distal portion of the horizontal duodenum with a pancreaticobiliary union outside the duodenal wall.
  • All the above findings were confirmed by subsequent surgery, thus contrast-enhanced MDCT and MRI with appropriate image post-processing could provide non-invasive and accurate information regarding anatomy and lesions of the pancreaticobiliary duct and duodenal union, which may improve the feasibility of surgery and reduce postoperative complications.
  • [MeSH-major] Adenoma / ultrasonography. Common Bile Duct / abnormalities. Jejunal Neoplasms / surgery. Pancreatic Ducts / abnormalities

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  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
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  • [Other-IDs] NLM/ PMC2747074
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63. Igarashi Y, Okano N, Ito K, Mimura T, Nakano S: Endoscopic snare excision of a major duodenal papillary tumor. Dig Surg; 2010;27(2):119-22
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  • BACKGROUND/AIMS: Tumors of the duodenal papilla include hyperplasia, adenoma, carcinoma in adenoma, and carcinoma.
  • METHODS: In patients with adenoma or early carcinoma of the papilla, endoscopic snare excision is indicated for complete removal of the tumor.
  • [MeSH-major] Ampulla of Vater / surgery. Cholangiopancreatography, Endoscopic Retrograde. Common Bile Duct Neoplasms / surgery

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  • [Copyright] (c) 2010 S. Karger AG, Basel.
  • (PMID = 20551655.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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64. Kondo S, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M, Furuse J, Saito H, Tsuyuguchi T, Yamamoto M, Kayahara M, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Hirano S, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japan Society of Clinical Oncology: Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment. J Hepatobiliary Pancreat Surg; 2008;15(1):41-54
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  • Although hepatectomy and/or pancreaticoduodenectomy are preferable for the curative resection of bile duct cancer, extrahepatic bile duct resection alone is also considered in patients for whom it is judged that curative resection would be achieved after a strict diagnosis of its local extension.
  • Prognostic factors after resection for bile duct cancer include positive surgical margins, especially in the ductal stump; lymph node metastasis; perineural invasion; and combined vascular resection due to portal vein and/or hepatic artery invasion.
  • For patients with suspected gallbladder cancer, laparoscopic cholecystectomy is not recommended, and open cholecystectomy should be performed as a rule.
  • Pancreaticoduodenectomy is indicated for ampullary carcinoma, and limited operation is also indicated for carcinoma in adenoma.

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  • (PMID = 18274843.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC2794356
  • [Investigator] Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
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65. Nguyen N, Shah JN, Binmoeller KF: Outcomes of endoscopic papillectomy in elderly patients with ampullary adenoma or early carcinoma. Endoscopy; 2010 Nov;42(11):975-7
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  • [Title] Outcomes of endoscopic papillectomy in elderly patients with ampullary adenoma or early carcinoma.
  • There were no differences in procedural success (100%), bleeding (5/14 vs. 6/22), adenoma recurrence (0/14 vs. 2/22) and median survival (24.0 vs. 25.5 months) between the elderly and younger patients.
  • In younger patients, although adenoma recurrences (n=2) were managed endoscopically, invasive adenocarcinomas (n=3) were treated by pancreatoduodenectomy.
  • [MeSH-major] Adenoma, Acidophil / surgery. Ampulla of Vater / surgery. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Endoscopy, Gastrointestinal

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 21072717.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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66. Verslype C, Libbrecht L: The multidisciplinary management of gastrointestinal cancer. The diagnostic and therapeutic approach for primary solid liver tumours in adults. Best Pract Res Clin Gastroenterol; 2007;21(6):983-96
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  • The finding of a focal solid liver lesion represents a challenge for the clinician in terms of the most optimal diagnostic and therapeutic algorithm.
  • Tumours may arise from hepatocytes (hepatocellular adenoma, dysplastic nodules and carcinoma), bile ducts (cholangiocarcinoma) or mesenchymal tissue (hemangioma, epithelioid haemangioendothelioma), or are metastases from primary tumours outside the liver.
  • More insight has been gathered recently in the histological classification of hepatocellular adenomas, but the differential diagnosis by imaging of adenoma versus FNH or well-differentiated hepatocellular carcinoma remains often difficult.
  • [MeSH-major] Bile Duct Neoplasms. Liver Cirrhosis / complications. Liver Neoplasms. Precancerous Conditions
  • [MeSH-minor] Adenoma, Liver Cell / diagnosis. Adenoma, Liver Cell / etiology. Adenoma, Liver Cell / therapy. Adult. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / etiology. Carcinoma, Hepatocellular / therapy. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / etiology. Cholangiocarcinoma / therapy. Diagnosis, Differential. Focal Nodular Hyperplasia / diagnosis. Focal Nodular Hyperplasia / etiology. Focal Nodular Hyperplasia / therapy. Hemangioma / diagnosis. Hemangioma / etiology. Hemangioma / therapy. Humans

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  • (PMID = 18070699.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 47
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67. Marcos Hernández R, Rodríguez Pascual A, Martín Fernández J, Ramos Guillén P, Galván Huarte M, Gutiérrez Calvo A, Díez Alonso M, Granell Vicent FJ: [Hepatobiliary cystoadenomas]. Cir Esp; 2006 Jun;79(6):375-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Bile Duct / complications. Adenoma, Liver Cell / complications

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  • (PMID = 16769003.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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68. Hai S, Yamamoto S, Tanaka H, Takemura S, Ichikawa T, Kodai S, Shinkawa H, Yamamoto T, Kubo S: Adenomyoma of the common hepatic duct mimicking bile duct cancer: report of a case. Surg Today; 2007;37(7):608-11
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  • [Title] Adenomyoma of the common hepatic duct mimicking bile duct cancer: report of a case.
  • We report an unusual case of adenomyoma of the common hepatic duct mimicking bile duct cancer.
  • Laboratory data showed abnormal liver test results and computed tomography showed a mass lesion in the hepatic hilum and dilatation of the intrahepatic bile ducts.
  • These findings led to a preoperative diagnosis of hilar bile duct carcinoma, and we performed a left lobectomy with resection of the extrahepatic bile duct.
  • Macroscopically, an elevated lesion was found in the common hepatic duct, which was confirmed histologically to be an adenomyoma.
  • Bile duct strictures are rarely caused by benign tumors of the biliary tract, such as adenomyoma.
  • Surgical resection of the bile duct should be considered for all bile duct strictures because it is often difficult to differentiate malignant from benign lesions in this location preoperatively, and malignant cells may be present in the lesion.
  • [MeSH-major] Adenoma / diagnosis. Bile Duct Neoplasms / diagnosis. Cholangiocarcinoma / diagnosis. Hepatic Duct, Common

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  • (PMID = 17593484.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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69. Schönleben F, Qiu W, Allendorf JD, Chabot JA, Remotti HE, Su GH: Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas. J Gastrointest Surg; 2009 Aug;13(8):1510-6
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  • [Title] Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas.
  • BACKGROUND: Mutations of KRAS are known to occur in periampullary and ampullary adenomas and carcinomas.
  • This study aimed to elucidate possible roles of BRAF and PIK3CA in the development of ampullary and periampullary adenomas and carcinomas.
  • METHODS: Mutations of BRAF, NRAS, HRAS, KRAS, and PIK3CA were evaluated in seven adenomas, seven adenomas with carcinoma in situ, and 21 adenocarcinomas of the periampullary duodenal region and the ampulla of Vater.

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  • (PMID = 19440799.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA109525-05; United States / NCI NIH HHS / CA / R21 CA127701; United States / NCI NIH HHS / CA / CA127701-01A2; United States / NCI NIH HHS / CA / R01CA109525; United States / NCI NIH HHS / CA / R01 CA109525; United States / NCI NIH HHS / CA / CA109525-05; United States / NCI NIH HHS / CA / R21 CA127701-01A2; United States / NCI NIH HHS / CA / R21CA127701
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ NIHMS164917; NLM/ PMC3915027
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70. Yopp AC, Pulipati R, Chorost MI, Horovitz JH: Cystic duct biliary adenoma. Surgery; 2008 Jan;143(1):150-1
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  • [Title] Cystic duct biliary adenoma.
  • [MeSH-major] Adenoma / radiography. Bile Duct Neoplasms / radiography. Cholecystectomy. Cholecystography. Cystic Duct / radiography

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  • (PMID = 18163276.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Yaman B, Nart D, Yilmaz F, Coker A, Zeytunlu M, Kilic M: Biliary intraductal papillary mucinous neoplasia: three case reports. Virchows Arch; 2009 May;454(5):589-94
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  • b-IPMN is classified as adenoma, borderline tumor, carcinoma in situ, and carcinoma, from benign to malignant.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Papillary / pathology. Cholangiocarcinoma / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Disease-Free Survival. Hepatitis B / complications. Hepatitis B / surgery. Humans. Immunoenzyme Techniques. Liver Cirrhosis / surgery. Liver Cirrhosis / virology. Liver Transplantation. Male. Middle Aged. Mucin 5AC / metabolism. Mucin-1 / metabolism. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Treatment Outcome

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  • [Language] eng
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72. Alvaro D, Cannizzaro R, Labianca R, Valvo F, Farinati F, Italian Society of Gastroenterology (SIGE), Italian Association of Hospital Gastroenterology (AIGO), Italian Association of Medical Oncology (AIOM), Italian Association of Oncological Radiotherapy (AIRO): Cholangiocarcinoma: A position paper by the Italian Society of Gastroenterology (SIGE), the Italian Association of Hospital Gastroenterology (AIGO), the Italian Association of Medical Oncology (AIOM) and the Italian Association of Oncological Radiotherapy (AIRO). Dig Liver Dis; 2010 Dec;42(12):831-8
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  • The incidence of Cholangiocellular carcinoma (CCA) is increasing, due to a sharp increase of the intra-hepatic form.
  • Evidence-ascertained risk factors for CCA are primary sclerosing cholangitis, Opistorchis viverrini infection, Caroli disease, congenital choledocal cist, Vater ampulla adenoma, bile duct adenoma and intra-hepatic lithiasis.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / therapy

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  • [Copyright] Copyright © 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20702152.001).
  • [ISSN] 1878-3562
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] Netherlands
  • [Investigator] Avuzzi B; Buscarini E; Fornasarig M; Iacono C; Maiero S; Mosconi S; Muto P; Tasca C; Vanin V
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73. Winter JM, Cameron JL, Olino K, Herman JM, de Jong MC, Hruban RH, Wolfgang CL, Eckhauser F, Edil BH, Choti MA, Schulick RD, Pawlik TM: Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis. J Gastrointest Surg; 2010 Feb;14(2):379-87
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  • METHODS: Between 1970 and 2007, 450 patients who underwent surgical resection of ampullary adenoma or adenocarcinoma were identified from a prospective, single-institution database.
  • Final diagnosis was invasive adenocarcinoma (77.1%) or adenoma (22.9%).
  • Median tumor size was similar for adenomas associated with an adenocarcinoma (2.5 cm) versus adenomas without invasive cancer (2.9 cm; P=0.71).
  • Metastatic disease to regional lymph nodes was present in 54.5% patients with adenocarcinoma.
  • CONCLUSION: When surgery is indicated, radical resection is required for early invasive adenocarcinoma of the ampulla of Vater, as lymph node metastases are present in nearly 30% of patients with T1 disease.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery

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  • (PMID = 19911239.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 1KL2RR025006-01
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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74. Rossaak J, Bagshaw P, Connor S: Management of Duodenal Adenomas Involving the Ampulla of Vater - A Warning against Limited Resection. Case Rep Gastroenterol; 2008;2(1):96-102
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  • [Title] Management of Duodenal Adenomas Involving the Ampulla of Vater - A Warning against Limited Resection.
  • Duodenal adenomas are uncommon, however, when present a proportion have dysplasia associated with the adenoma and therefore require treatment.
  • This case report describes two patients with adenomas involving the ampulla of Vater.
  • One patient had familial adenomatous polyposis, the other was a renal transplant patient with a large adenoma.
  • Both patients' adenomas contained high-grade dysplasia.
  • Histology of both specimens demonstrated that the adenoma had migrated up the bile duct for at least 7 mm, and the pancreatic duct for 8 mm in one patient.
  • Limited resection of ampullary adenomas may leave residual adenomatous tissue in the bile duct with the risk of recurrent adenomatous disease and malignant transformation.

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  • (PMID = 21490846.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3075174
  • [Keywords] NOTNLM ; Ampullary adenoma/carcinoma / Duodenal adenoma/carcinoma / High-grade dysplasia / Management / Surgery
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75. Akaydin M, Ersoy YE, Erozgen F, Ferlengez E, Kaplan R, Celik A, Memmi N: Tubulovillous adenoma in the common bile duct causing obstructive jaundice. Acta Gastroenterol Belg; 2009 Oct-Dec;72(4):450-4
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  • [Title] Tubulovillous adenoma in the common bile duct causing obstructive jaundice.
  • Villous adenomas are benign epithelial lesions with a malignant potential which can occur at any site in the gastrointestinal tract, usually in the rectum and colon, less frequently in the small bowel and very rarely in the biliary tract.
  • Villous adenomas of the extrahepatic bile ducts are exceptional and only a few cases have been reported.
  • Common bile duct (CBD) adenomas often present in a fashion similar to their malignant counterparts, and adenocarcinoma arising from a villous adenoma of the ampullary biliary epithelium is also extremely rare.
  • We present here a tubulovillous adenoma, arising in the common bile duct, as a cause of obstructive jaundice, and discuss the characteristics of these lesions.
  • [MeSH-major] Adenoma, Villous / complications. Common Bile Duct Neoplasms / complications. Jaundice, Obstructive / etiology

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  • (PMID = 20163042.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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76. Fukushima H, Yamamoto H, Nakano H, Nakazawa K, Sunada K, Wada S, Tamada K, Sugano K: Complete en bloc resection of a large ampullary adenoma with a focal adenocarcinoma by using endoscopic submucosal dissection (with video). Gastrointest Endosc; 2009 Sep;70(3):592-5
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  • [Title] Complete en bloc resection of a large ampullary adenoma with a focal adenocarcinoma by using endoscopic submucosal dissection (with video).
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / surgery. Adenoma, Bile Duct / pathology. Ampulla of Vater / pathology. Cell Transformation, Neoplastic / pathology. Duodenal Neoplasms / surgery. Duodenoscopy / methods

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  • (PMID = 19403130.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Webcasts
  • [Publication-country] United States
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77. Han J, Lee SK, Park DH, Choi JS, Lee SS, Seo DW, Kim MH: [Treatment outcome after endoscopic papillectomy of tumors of the major duodenal papilla]. Korean J Gastroenterol; 2005 Aug;46(2):110-9
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  • BACKGROUND/AIMS: Endoscopic papillectomy is reported to be relatively safe and reliable for complete resection of benign tumors of the major duodenal papilla.
  • Histopathologic evaluation after endoscopic papillectomy revealed adenoma (n=11, 50%), high-grade dysplasia (n=3, 13.6%), adenocarcinoma (n=2, 9.1%), carcinoid (n=1), chronic inflammation (n=3, 13.6%), papillary adenomatous hyperplasia (n=1), and cavernous lymphangioma (n=1).
  • A pancreatic duct stent was placed in 11 patients (50.0%) and was removed after 3 to 39 days.
  • There were 8 (36.8%) procedure-related complications: bleeding (n=4), papillary stenosis (n=1), perforation (n=1), cholangitis (n=1), and asymptomatic liver function abnormality (n=1).
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Sphincterotomy, Endoscopic

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  • (PMID = 16118521.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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78. Targarona Modena J, Rosamedina JL, Garatea R, Romero C, Lora A, Contardo C, Mantila L, Yabar A, Montoya E: [Transduodenal ampullectomy: an useful alternative for the treatment of Vater's ampulla lesions. Case reports of an unfrecuent surgical technique]. Rev Gastroenterol Peru; 2005 Jan-Mar;25(1):106-11
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  • [Transliterated title] Ampulectomía transduodenal una alternativa útil para el tratamiento de las lesiones de la ampolla de Vater: reporte de casos de una técnica raramente utilizada.
  • The ampullectomy consists on the total resection of the Vater's ampulla and part of the duodenal wall with the later reconstruction and anastomosis of the common bile duct and the Wirsung's duct to the duodenum.
  • The local resection of the ampulla is an alternative to the duodenopancreatectomy that has to be taken into account, especially in benign lesions as in the case of adenomas of the Vater's ampulla.
  • Here we describe two cases one with adenoma of the Vater's ampulla, with a high degree dysplasia, who first underwent an ampullectomy and finally ended up in a duodenopancreatectomy due to the infiltration of the adenoma into the edge of section and other case of Lymphangioma of Vater's ampulla with no infiltration in the edge of section.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery

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  • (PMID = 15818426.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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79. Sohn VY, Arthurs ZM, Martin MJ, Sebesta JA, Branch JB, Champeaux AL: Incidental pathologic findings in open resectional gastric bypass specimens with routine cholecystectomy and appendectomy. Surg Obes Relat Dis; 2008 Sep-Oct;4(5):608-11
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  • This procedure allows for pathologic assessment of otherwise normal viscera routinely removed as a part of the gastric bypass.
  • In the gallbladder the sole abnormality, other than cholelithiasis, was an adenomyoma.
  • Other resected findings included five Meckel's diverticula, one bile duct adenoma, and one sigmoid diverticulum.

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  • (PMID = 18586563.001).
  • [ISSN] 1550-7289
  • [Journal-full-title] Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
  • [ISO-abbreviation] Surg Obes Relat Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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80. Boix J, Lorenzo-Zúñiga V, Moreno de Vega V, Domènech E, Gassull MA: Endoscopic resection of ampullary tumors: 12-year review of 21 cases. Surg Endosc; 2009 Jan;23(1):45-9
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  • BACKGROUND: Endoscopic snare papillectomy is increasingly performed with curative intent for benign papillary tumors.
  • RESULTS: Of the 21 patients (9 men and 12 women; mean age, 67.2 +/- 14.3 years) evaluated, 11 had adenoma (7 had low-grade dysplasia [LGD] and 4 had high-grade dysplasia [HGD]), and 10 had carcinoma.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater. Carcinoma / surgery. Cholangiopancreatography, Endoscopic Retrograde. Common Bile Duct Neoplasms / surgery. Sphincterotomy, Endoscopic

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  • (PMID = 18398649.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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81. Nassar H, Albores-Saavedra J, Klimstra DS: High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases. Am J Surg Pathol; 2005 May;29(5):588-94
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  • Overall, 64% of patients with ampullary HGNEC died of disease (mean follow-up, 14.5 months).
  • Four patients had no evidence of disease after resection (mean, 20 months).
  • Half of the tumors were associated with adenomas of the adjacent mucosa, 2 with high-grade dysplasia.
  • The association with adenoma and or conventional adenocarcinoma components may suggest a common pathway in the initial carcinogenesis of these two types of tumors.
  • Loss of Rb expression, a characteristic finding in pulmonary SCCs, is present in almost half of ampullary HGNECs.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoma, Neuroendocrine / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 15832081.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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82. Fishman DS, Tarnasky PR, Patel SN, Raijman I: Management of pancreaticobiliary disease using a new intra-ductal endoscope: the Texas experience. World J Gastroenterol; 2009 Mar 21;15(11):1353-8
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  • [Title] Management of pancreaticobiliary disease using a new intra-ductal endoscope: the Texas experience.
  • AIM: To evaluate a new single-operator mini-endoscope, Spyglass, for its performance, feasibility and safety in the management of pancreaticobiliary disease.
  • [MeSH-minor] Adenoma / pathology. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / pathology. Bile Ducts / pathology. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / pathology. Choledocholithiasis / diagnosis. Endoscopy, Digestive System / instrumentation. Endoscopy, Digestive System / methods. Female. Gallstones / diagnosis. Gallstones / surgery. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 19294765.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2658829
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83. Tajima Y, Tomioka T, Ikematsu Y, Yamanaka S, Kuroki T, Kitajima T, Fukuda K, Tsuneoka N, Kitazato A, Adachi T, Kanematsu T: Experimental study on pathogenesis and histomorphology of early carcinoma of the extrahepatic bile duct in the Syrian hamster. J Exp Clin Cancer Res; 2005 Sep;24(3):475-82
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  • [Title] Experimental study on pathogenesis and histomorphology of early carcinoma of the extrahepatic bile duct in the Syrian hamster.
  • To elucidate the pathogenesis of carcinomas in the extrahepatic bile duct, we investigated the histomorphological characteristics of adenomas and early carcinomas induced in the extrahepatic bile duct of hamsters.
  • Syrian hamsters underwent a cholecystoduodenostomy along with a dissection of the common duct, while also being administered N-nitrosobis(2-oxopropyl)amine (BOP).
  • The tumors that arose from the extrahepatic bile duct included 10 adenomas and 55 early carcinomas in 56 of the 156 hamsters sacrificed.
  • All the adenomas were found to be polypoid in shape.
  • The early carcinomas, which were restricted within the mucosal layer of the bile duct, showed the following three different growth patterns:.
  • Carcinomas existing either alone or associated with adenomas were evident in 12 (22%) tumors, and 11 of these were polypoid.
  • These results support the concept of an adenoma-carcinoma sequence in the majority of polypoid tumors of the extrahepatic bile duct.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Extrahepatic / pathology
  • [MeSH-minor] Adenoma / pathology. Animals. Carcinoma / pathology. Cricetinae. Disease Models, Animal. Female. Incidence. Mesocricetus

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  • (PMID = 16270535.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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84. Matsusaki S, Maguchi H, Takahashi K, Katanuma A, Osanai M, Urata T, Fukasawa M, Tsuchiya T, Ichiya T, Kurita A, Ambo Y, Nakamura F: [Clinical features of acute acalculous cholecystits-nosocomial manner and community-acquired manner]. Nihon Shokakibyo Gakkai Zasshi; 2008 Dec;105(12):1749-57
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  • Functional bile stasis caused AAC in 34 of 113 cases (30.1%), and 28 of those developed in a nosocomial manner (82.4%).
  • On the contrary, mechanical bile stasis caused 37 cases (32.7%), and all but one case developed in a community-acquired manner. mechanical bile stasis included 9 cases of biliary tract neoplasm (5, cystic duct cancer; 3, gallbladder cancer; 1, papillary adenoma).

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  • (PMID = 19057160.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
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85. Defrain C, Chang CY, Srikureja W, Nguyen PT, Gu M: Cytologic features and diagnostic pitfalls of primary ampullary tumors by endoscopic ultrasound-guided fine-needle aspiration biopsy. Cancer; 2005 Oct 25;105(5):289-97
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  • Adenoma was diagnosed in two patients and carcinoid tumor in one.
  • Adenoma presented a diagnostic challenge and endosonographic correlation was instrumental to increase the diagnostic accuracy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenoma / diagnosis. Adenoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / pathology

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  • (PMID = 15986397.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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86. Deschamps L, Dokmak S, Guedj N, Ruszniewski P, Sauvanet A, Couvelard A: Mixed endocrine somatostatinoma of the ampulla of vater associated with a neurofibromatosis type 1: a case report and review of the literature. JOP; 2010;11(1):64-8
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  • Endoscopic examination revealed a tumor involving the ampulla of Vater and a CT scan identified stenoses of both the distal common bile duct and the main pancreatic duct.
  • A pancreaticoduodenectomy was performed and pathological examination revealed two tumor components, exocrine (high grade adenoma with infiltrative adenocarcinoma) and endocrine (expressing somatostatin hormone) with lymph node metastases originating from both types.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Mixed Tumor, Malignant / diagnosis. Neurofibromatosis 1 / diagnosis. Somatostatinoma / diagnosis


87. Kunisaki SM, Hertl M, Bodner BE, Cosimi AB: Mirizzi syndrome secondary to an adenoma of the cystic duct. J Hepatobiliary Pancreat Surg; 2005;12(2):159-62
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  • [Title] Mirizzi syndrome secondary to an adenoma of the cystic duct.
  • Bile duct adenomas are uncommon lesions that can cause obstructive jaundice.
  • We report the unusual case of a 54-year-old man who developed Mirizzi syndrome secondary to a bile duct papillary adenoma located in the cystic duct remnant.
  • A case report is presented, together with a review of extrahepatic bile duct adenomas published in the English-language literature, with special attention directed toward the clinical manifestations, locations, and prognosis of these tumors.
  • Bile duct adenomas are very rare tumors.
  • Most lesions were located in the distal common bile duct or at the ampulla of Vater.
  • There were no previous case reports of extrinsic common bile duct obstruction caused by tumors within the cystic duct.
  • We describe here a very rare, acalculous variant of Mirizzi syndrome secondary to a solitary papillary adenoma of the cystic duct.
  • In general, bile duct adenomas are uncommon lesions that are difficult to diagnoses preoperatively.
  • [MeSH-major] Adenoma / complications. Bile Duct Neoplasms / complications. Cholestasis / etiology. Cystic Duct

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  • (PMID = 15868083.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 28
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88. Ishibashi Y, Ojima H, Hiraoka N, Sano T, Kosuge T, Kanai Y: Invasive biliary cystic tumor without ovarian-like stroma. Pathol Int; 2007 Dec;57(12):794-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Microscopically the tumor showed three types of neoplasia: adenoma and tubulopapillary adenocarcinoma in the cystic area, and invasive adenocarcinoma in the solid area.
  • Moreover, transitional zones between adenoma and tubulopapillary adenocarcinoma, and between tubulopapillary adenocarcinoma and invasive adenocarcinoma were noted.
  • The immunohistochemical expression of Ki-67 and p53 increased gradually from adenoma through to tubulopapillary adenocarcinoma, and was highest in invasive adenocarcinoma.
  • No ovarian-like stroma or communication with the bile ducts around the tumor was found in any area of the specimen.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Cystadenocarcinoma / pathology. Ovary / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adenocarcinoma, Papillary / metabolism. Adenocarcinoma, Papillary / pathology. Adenoma / metabolism. Adenoma / pathology. Female. Humans. Hypertension / pathology. Immunohistochemistry. Incidental Findings. Ki-67 Antigen / biosynthesis. Middle Aged. Mucin-1 / biosynthesis. Tumor Suppressor Protein p53 / biosynthesis


89. Sakai Y, Tsuyuguchi T, Tsuchiya S, Fukuda Y, Miyakawa K, Sugiyama H, Yokosuka O, Ohtsuka M, Miyazaki M: Value of peroral cholangioscopy for mucin-producing bile duct tumor. Hepatogastroenterology; 2008 Jan-Feb;55(81):58-61
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  • [Title] Value of peroral cholangioscopy for mucin-producing bile duct tumor.
  • Mucin-producing bile duct tumor is a rare biliary tract tumor.
  • Despite the development of modern diagnostic technologies such as ultrasonography, and angiography, the precise determination of this tumor is difficult because of ambiguity caused by the abundant mucin secreted by the tumor and/or by the superficial mucosal spread of the tumor along the bile duct.
  • We report the case of a patient who underwent the successful resection of a mucin-producing bile duct tumor.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / surgery. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / surgery. Endoscopy, Digestive System. Mucins / biosynthesis

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  • (PMID = 18507079.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Mucins
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90. National Toxicology Program: Toxicology and carcinogenesis studies of 3,3',4,4'-tetrachloroazobenzene (TCAB) (CAS No. 14047-09-7) in Harlan Sprague-Dawley rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Nov;(558):1-206
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  • Humans may be exposed to TCAB during the manufacture as well as the application of herbicides containing TCAB as a contaminant.
  • A significant dose-related increase in hepatic toxicity was observed in dosed rats and was characterized by increased incidences of numerous lesions including hepatocyte hypertrophy, centrilobular degeneration, hepatocellular necrosis, pigmentation, fatty change, bile duct hyperplasia, oval cell hyperplasia, nodular hyperplasia, hematopoietic cell proliferation, eosinophilic focus, mixed cell focus, multinucleated hepatocytes, bile duct cyst, toxic hepatopathy, and cholangiofibrosis.
  • The incidences of follicular cell adenoma (single or multiple) of the thyroid gland in 30 and 100 mg/kg males were significantly greater than that in the vehicle control group.
  • In the adrenal cortex of 30 and 100 mg/kg females, there were slightly increased incidences of adenoma.

  • Hazardous Substances Data Bank. 3,4,3',4'-Tetrachloroazobenzene .
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  • (PMID = 21383777.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Azo Compounds; 0 / Chlorobenzenes; 14047-09-7 / 3,4,3',4'-tetrachloroazobenzene
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91. Ito K, Fujita N, Noda Y, Kobayashi G, Horaguchi J: Diagnosis of ampullary cancer. Dig Surg; 2010;27(2):115-8
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  • Endoscopic papillectomy has been reported to be the treatment of choice in patients with ampullary adenoma.
  • Since neither lymphatic permeation, vascular invasion, nor lymph node metastasis is observed in patients with ampullary cancer limited to the mucosa, endoscopic resection of such tumors can be justified if no ductal infiltration into the bile or pancreatic duct is documented.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis

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  • [Copyright] (c) 2010 S. Karger AG, Basel.
  • (PMID = 20551654.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 17
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92. Celli N, Gaiani S, Piscaglia F, Zironi G, Camaggi V, Leoni S, Righini R, Bolondi L: Characterization of liver lesions by real-time contrast-enhanced ultrasonography. Eur J Gastroenterol Hepatol; 2007 Jan;19(1):3-14
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  • OBJECTIVE: The aim of this study was to identify the most common patterns of various common liver lesions at real-time contrast-enhanced ultrasonography with second-generation contrast agents and their role in the differentiation of malignant from benign lesions.
  • PATIENTS AND METHODS: The enhancement pattern in the arterial phase and its modifications in subsequent portal and sinusoidal phases were separately evaluated in (i) 171 liver lesions detected at conventional ultrasonography in 125 noncirrhotic patients (87 metastases, six cholangiocellular carcinoma, 38 focal nodular hyperplasia, 30 hemangiomas, seven focal fatty sparing/changes, two hepatocellular adenomas and one hepatocellular carcinoma) and (ii) 75 lesions detected in 67 cirrhotic patients (66 hepatocellular carcinoma and nine dysplastic nodules).
  • CONCLUSION: Real-time contrast-enhanced ultrasonography provides sensitive and specific criteria for the differential diagnosis between benign and malignant liver lesions, and in most cases it may replace more expensive and invasive imaging techniques.
  • [MeSH-minor] Adenoma, Liver Cell / ultrasonography. Adult. Aged. Aged, 80 and over. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / ultrasonography. Cholangiocarcinoma / ultrasonography. Diagnosis, Differential. Female. Focal Nodular Hyperplasia / ultrasonography. Hemangioma / ultrasonography. Humans. Image Processing, Computer-Assisted / methods. Magnetic Resonance Imaging / methods. Male. Microbubbles. Middle Aged. Ultrasonography, Doppler / methods

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  • (PMID = 17206071.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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93. Gambarotti M, Medicina D, Baronchelli C, Bercich L, Bonetti F, Facchetti F: Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. Int J Surg Pathol; 2008 Apr;16(2):218-21
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  • [Title] Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation.
  • The nodule showed the histological features of a bile duct adenoma.
  • The selective recurrence of large alpha-1-antitrypsin globules within the bile ducts may indicate a neoplastic rather than a reactive or hamartomatous nature of the nodule.
  • [MeSH-major] Adenoma / genetics. Bile Duct Neoplasms / genetics. Bile Ducts, Intrahepatic. Mutation. alpha 1-Antitrypsin / genetics

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  • (PMID = 18417685.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha 1-Antitrypsin
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94. National Toxicology Program: Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (Cas No. 31508-00-6) in female Harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser; 2006 Nov;(531):1-218
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  • Since human exposure to DLCs always occurs as a complex mixture, the toxic equivalency factor (TEF) methodology has been developed as a mathematical tool to assess the health risk posed by complex mixtures of these compounds.
  • Therefore, this study was reclassified as a mixture study of PCB 126 and PCB 118.
  • At the end of the 2-year study in all dosed groups, there were significantly increased incidences and severity of toxic hepatopathy characterized by hepatocyte hypertrophy, multinucleated hepatocytes, pigmentation, toxic hepatopathy, diffuse fatty change, nodular hyperplasia, centrilobular fibrosis, cholangiofibrosis, oval cell hyperplasia, bile duct cyst, bile duct hyperplasia, and portal fibrosis.
  • The incidences of hepatocellular adenoma were also significantly increased in the 216 and 360 ng TEQ/kg core study groups.
  • In addition, single occurrences of hepatocholangioma, cholangioma, or hepatocellular carcinoma were observed in some dosed groups administered 72 ng TEQ/kg or greater.

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  • (PMID = 17342196.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Thyroid Hormones; 31508-00-6 / 2,3',4,4',5-pentachlorobiphenyl; DFC2HB4I0K / Polychlorinated Biphenyls; TSH69IA9XF / 3,4,5,3',4'-pentachlorobiphenyl
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95. Zen Y, Fujii T, Itatsu K, Nakamura K, Konishi F, Masuda S, Mitsui T, Asada Y, Miura S, Miyayama S, Uehara T, Katsuyama T, Ohta T, Minato H, Nakanuma Y: Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct. Mod Pathol; 2006 Sep;19(9):1243-54
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  • [Title] Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct.
  • Biliary cystic tumors, which are also called biliary cystadenoma and cystadenocarcinoma, are thought to be a heterogeneous disease entity, and some of them are known to show a luminal communication to the bile duct.
  • In this study, we examined the clinicopathological features of nine cases of biliary cystic tumors with bile duct communication.
  • A direct luminal communication with the bile ducts was identified in five cases on preoperative or intraoperative cholangiographies.
  • Biliary cystic tumors examined in this study were histologically adenoma (one case), adenocarcinoma in situ (six cases), and adenocarcinoma associated with microinvasive mucinous carcinoma (two cases).
  • One case of adenocarcinoma in situ also had the adenoma component (adenocarcinoma in adenoma).
  • Intraepithelial neoplasm was observed within non-dilated adjacent bile ducts, suggesting a direct luminal communication between the cystic tumors and the bile duct.
  • These clinicopathological features resembled those of intraductal papillary neoplasm of the bile duct, which had been reported as a biliary counterpart of pancreatic intraductal papillary mucinous neoplasm.
  • In conclusion, biliary cystic tumors with bile duct communication could be regarded as intraductal papillary neoplasm with a prominent cystic dilatation of the bile duct and mucin retention, rather than true biliary cystic neoplasms.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Cystadenocarcinoma / pathology. Cystadenoma / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinoma in Situ. Disease-Free Survival. Female. Fluorescent Antibody Technique, Indirect. Homeodomain Proteins / metabolism. Humans. Immunoenzyme Techniques. Male. Middle Aged. Mucin-1 / metabolism. Mucin-2. Mucins / secretion. Trans-Activators / metabolism

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  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • [Copyright] Published online 2 June 2006.
  • (PMID = 16741522.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Homeodomain Proteins; 0 / MUC2 protein, human; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins; 0 / Trans-Activators; 156560-97-3 / Cdx-2-3 protein
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96. Mutignani M, Seerden T, Tringali A, Feisal D, Perri V, Familiari P, Costamagna G: Endoscopic hemostasis with fibrin glue for refractory postsphincterotomy and postpapillectomy bleeding. Gastrointest Endosc; 2010 Apr;71(4):856-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma / surgery. Adult. Aged, 80 and over. Cholangiography. Common Bile Duct Neoplasms / surgery. Duodenoscopy. Female. Gallstones / surgery. Humans. Injections

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  • [Copyright] Copyright 2010. Published by Mosby, Inc.
  • (PMID = 20363432.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive
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97. Janes S: Medical image. Ampullary mass and obstructive jaundice. N Z Med J; 2005 Nov 11;118(1225):U1738
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / radiography. Ampulla of Vater / radiography. Common Bile Duct Neoplasms / radiography. Duodenal Neoplasms / pathology. Jaundice, Obstructive / etiology. Neoplasms, Multiple Primary / radiography

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  • (PMID = 16286948.001).
  • [ISSN] 1175-8716
  • [Journal-full-title] The New Zealand medical journal
  • [ISO-abbreviation] N. Z. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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98. Kim HG: [Biliary cystic neoplasm: biliary cystadenoma and biliary cystadenocarcinoma]. Korean J Gastroenterol; 2006 Jan;47(1):5-14
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  • Most biliary cystic tumors arise from intrahepatic bile duct and 10-20% arise from extrahepatic bile duct like common hepatic duct, common bile duct, and gallbladder.
  • The epithelial lining of cystadenocarcinoma exhibits cellular atypia, mitotic activity, and infiltrative growth, but part of lining epithelium retain the feature of cystadenoma, which support the adenoma-carcinoma sequence.

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  • (PMID = 16434863.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 64
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99. Zhang L, Han F, Huang CS, Pang C, Han YZ, Hua YW: [Analysis of the treatment of unexpected gallbladder cancer]. Zhonghua Wai Ke Za Zhi; 2005 Apr 1;43(7):460-2
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  • The 41 patients had undergone gallbladder excision because of cholecystitis complicated lithiasis of gallbladder (32 cases), polypi of gallbladder or adenoma (9 cases).
  • RESULTS: On the second operation, 14 cases were with lymphatic metastasis, 14 with gallbladder metastasis, 6 with bile duct metastasis, 2 with pancreas metastasis.

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  • (PMID = 15854374.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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100. Kristick KL, Ranck RS, Fink M: What is your diagnosis? Biliary cystadenoma of the liver causing deviation of the stomach to the left. J Am Vet Med Assoc; 2010 May 15;236(10):1065-6
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  • [MeSH-major] Adenoma, Bile Duct / veterinary. Bile Duct Neoplasms / veterinary. Bile Ducts, Intrahepatic. Cat Diseases / radiography. Stomach / radiography

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  • (PMID = 20470066.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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