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1. Roussel A, Thomassin-Naggara I, Darai E, Marsault C, Bazot M: [Value of diffusion-weighted imaging in the evaluation of adnexal tumors]. J Radiol; 2009 May;90(5 Pt 1):589-96

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of diffusion-weighted imaging in the evaluation of adnexal tumors].
  • [Transliterated title] Evaluation de la séquence de diffusion pour l'étude des tumeurs annexielles.
  • PURPOSE: To determine the value of diffusion-weighted imaging (DWI) in the evaluation of adnexal tumors, especially to distinguish between malignant and benign tumors.
  • Fifty-four patients with pelvic tumors (32 malignant and 22 benign) were referred for MRI of the pelvis.
  • The signal of solid and cystic tumor components was evaluated on T2W and b=1000 DWI, and ADC values were obtained.
  • RESULTS: T2W hypointensity or absence of hyperintense signal on b=1000 DWI sequences was suggestive of a benign tumor.
  • ADC values did not appear to discriminate between malignant and benign tumors.
  • Also, the signal intensity of cystic tumor components on DWI sequences was not helpful to distinguish between malignant and benign tumor.
  • CONCLUSION: The evaluation of solid tumor components on DWI appears to be helpful for adnexal tumor characterization.
  • [MeSH-major] Adnexal Diseases / diagnosis. Diffusion Magnetic Resonance Imaging / methods. Genital Neoplasms, Female / diagnosis. Image Enhancement. Image Processing, Computer-Assisted
  • [MeSH-minor] Adnexa Uteri / pathology. Adnexa Uteri / surgery. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Middle Aged. Sensitivity and Specificity. Young Adult

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  • (PMID = 19503047.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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2. Krishnamurthy J, Nagappa DK: The cytology of molluscum contagiosum mimicking skin adnexal tumor. J Cytol; 2010 Apr;27(2):74-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The cytology of molluscum contagiosum mimicking skin adnexal tumor.
  • The cytology of molluscum contagiosum in an 11-year-old boy, which presented atypically as a solitary nodule over the right cheek, mimicking a skin adnexal tumor is reported here.

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  • (PMID = 21157556.001).
  • [ISSN] 0974-5165
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3001182
  • [Keywords] NOTNLM ; Cytoplasmic inclusions / fine needle aspiration cytology / molluscum contagiosum
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3. Lee CY, Tseng CC, Wang CB, Lin YH, Chen CH, Wun TH, Sun YL, Tseng CJ: A new quantitative method to evaluate adnexal tumors. Taiwan J Obstet Gynecol; 2010 Mar;49(1):45-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A new quantitative method to evaluate adnexal tumors.
  • We chose quantitative tumor density and standard deviation on sonographic images as the new diagnostic parameters.
  • Analysis of variance and Scheffé post hoc test were analyzed to compare the mean tumor density of the endometriomas and follicular cysts.
  • The receiver operating characteristic curve was plotted to choose the cutoff value of the endometrioma tumor density with the best sensitivity and specificity.
  • RESULTS: There was a significant difference when the tumor density of the follicular cyst and endometrioma groups was compared using the vaginal, abdominal or endovaginal approach (p < 0.001).
  • With endovaginal ultrasonography examination, the best cutoff value of tumor density is 28 and the sensitivity and specificity are 64% and 100%, respectively.
  • CONCLUSION: The use of quantitative tumor density and standard deviation on sonographic images is a potential new diagnostic tool in the assessment of endometriomas and follicular cysts.
  • [MeSH-major] Adnexal Diseases / diagnosis. Endometriosis / diagnosis. Follicular Cyst / diagnosis. Ultrasonography / methods

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  • (PMID = 20466292.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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4. Navi D, Fung M, Lynch PJ: Poromatosis: the occurrence of multiple eccrine poromas. Dermatol Online J; 2008;14(1):3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eccrine poromas are rare, benign adnexal tumors derived from the intraepidermal portion of sweat ducts.
  • They usually appear as solitary, slow-growing, skin-colored papules on acral surfaces.

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  • (PMID = 18319020.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Gottwald L, Korczyński J, Góra E, Bieńkiewicz A: [Adnexal tumors after surgical treatment of colorectal cancer]. Ginekol Pol; 2008 Apr;79(4):259-63
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  • [Title] [Adnexal tumors after surgical treatment of colorectal cancer].
  • OBJECTIVE: The risk of metastatic ovarian tumor is significantly higher in case of women with a history of colorectal cancer.
  • DESIGN: The purpose of the study was to evaluate the clinical presentation and histopathology of adnexal tumors in case of female patients with a history of colorectal adenocarcinoma.
  • MATERIAL AND METHODS: A retrospective study on 13 women (each with a history of colorectal carcinoma, operated due to adnexal tumor between 2004 and 2007), has been conducted.
  • Subject characteristics, ultrasound, CT, serum tumor markers levels, histopathology and findings at surgery were analyzed.
  • RESULTS: Time distance between colorectal cancer surgery and ovarian tumor operation - measured in months -was shorter in cases of malignant neoplasms (10.13 +/- 3.98) than in benign tumors (26.2 +/- 19.37).
  • Ultrasound examination showed solid-cystic adnexal tumors in 8 malignant cases, and ovarian cysts in 5 benign conditions.
  • Unilateral adnexectomy only took place in one case of benign tumor and in one case of disseminated neoplasmatic disease.
  • CONCLUSIONS: When evaluating a patient with an adnexal tumor, a history of malignancy strongly suggests a metastatic nature.
  • The use of ultrasound associated with plasma levels of Ca 125, Ca 19-9 and CEA, represents a useful method of preoperative assessment of ovarian tumors.

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  • (PMID = 18592863.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen
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6. Obaidat NA, Alsaad KO, Ghazarian D: Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol; 2007 Feb;60(2):145-59

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands.
  • Tumours of cutaneous sweat glands are uncommon, with a wide histological spectrum, complex classification and many different terms often used to describe the same tumour.
  • In addition to the eccrine and apocrine glands, two other skin sweat glands have recently been described: the apoeccrine and the mammary-like glands of the anogenital area.
  • In this review (the second of two articles on skin adnexal neoplasms), common as well as important benign and malignant lesions of cutaneous sweat glands are described, and a summary for differentiating primary adnexal neoplasms from metastatic carcinoma is outlined, striving to maintain a common and acceptable terminology in this complex subject.
  • Composite/mixed adnexal tumours are also discussed briefly.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Adenoma, Sweat Gland / pathology. Carcinoma, Skin Appendage / pathology. Humans. Syringoma / pathology

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  • (PMID = 16882695.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 110
  • [Other-IDs] NLM/ PMC1860616
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7. Deen S, Duncan TJ, Hammond RH: Malignant female adnexal tumors of probable Wolffian origin. Int J Gynecol Pathol; 2007 Oct;26(4):383-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant female adnexal tumors of probable Wolffian origin.
  • Female adnexal tumors of probable Wolffian origin are rare.
  • Although the histological features of the benign tumors are recognized, features of malignancy are not well defined in published work because these tumors are particularly rare.
  • Immunohistochemical staining and electron microscopy supported the diagnosis of female adnexal tumor of probable Wolffian origin.
  • There was significant and widespread nuclear pleomorphism with increased mitotic activity endorsing the diagnosis of a malignant tumor.
  • Seven months after initial surgery, follow-up magnetic resonance imaging showed a mass with a maximum diameter of 7 cm in the region of the right adnexa consistent with a recurrence.
  • [MeSH-major] Adnexal Diseases / pathology. Wolffian Ducts / pathology

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  • (PMID = 17885487.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Van Holsbeke C, Van Calster B, Valentin L, Testa AC, Ferrazzi E, Dimou I, Lu C, Moerman P, Van Huffel S, Vergote I, Timmerman D, International Ovarian Tumor Analysis Group: External validation of mathematical models to distinguish between benign and malignant adnexal tumors: a multicenter study by the International Ovarian Tumor Analysis Group. Clin Cancer Res; 2007 Aug 1;13(15 Pt 1):4440-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] External validation of mathematical models to distinguish between benign and malignant adnexal tumors: a multicenter study by the International Ovarian Tumor Analysis Group.
  • PURPOSE: Several scoring systems have been developed to distinguish between benign and malignant adnexal tumors.
  • EXPERIMENTAL DESIGN: In phase I of the International Ovarian Tumor Analysis multicenter study, patients with a persistent adnexal mass were examined with transvaginal ultrasound and color Doppler imaging.
  • The outcome measure was the histologic classification of excised tissue as malignant or benign.
  • We used the International Ovarian Tumor Analysis data to test the accuracy of previously published scoring systems.
  • RESULTS: Data from 1,066 patients were included; 800 patients (75%) had benign tumors and 266 patients (25%) had malignant tumors.
  • The morphologic scoring system used by Lerner gave an area under the receiver operating characteristic curve (AUC) of 0.68, whereas the multimodal risk of malignancy index used by Jacobs gave an AUC of 0.88.
  • [MeSH-minor] Adnexal Diseases / classification. Adnexal Diseases / diagnosis. CA-125 Antigen. Diagnosis, Differential. Female. Humans. International Agencies. Logistic Models. Neural Networks (Computer). Prospective Studies

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  • (PMID = 17671128.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-125 Antigen
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9. Kazakov DV, Sima R, Vanecek T, Kutzner H, Palmedo G, Kacerovska D, Grossmann P, Michal M: Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors. Am J Dermatopathol; 2009 May;31(3):248-55
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  • [Title] Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
  • Previous studies suggested that mutant beta-catenin gene cells in cutaneous adnexal tumors with matrical differentiation contribute to their tumorigenesis.
  • Except for pilomatricoma and pilomatrical carcinoma, only a handful of other cutaneous adnexal tumor types have been studied.
  • DNA was extracted from 86 lesions including 17 proliferating tricholemmal and trichilemmal tumors, 15 trichoblastomas, 7 trichoadenomas, 4 pilomatricomas, 1 pilomatrical carcinoma, 4 basal cell carcinomas (BCCs) with shadow cells, 2 trichofolliculomas, 3 BCCs with sebaceous differentiation, 9 sebaceous adenomas, 6 sebaceomas, 14 sebaceous carcinomas (both ocular and extraocular forms), 2 gigantic horns, and 2 apocrine mixed tumors with shadow cells and subjected to polymerase chain reaction with newly designed primers encompassing glycogen synthase kinase-3beta phosphorylation sites of the CTNNB1 gene.
  • These included 5 different point mutations, 3 of them identified in 2 different tumors: S23N (cribriform trichoblastoma), D32Y (pilomatricoma and craniopharyngioma), G34R (pilomatrical carcinoma and craniopharyngioma), S37F (2 BCCs with shadow cell differentiation), and G34V (craniopharyngioma).
  • This study broadens the list of cutaneous adnexal tumors harboring CTNNB1 mutations and extends the listing of the mutations occurring in these neoplasms.
  • [MeSH-major] Exons. Mutation. Neoplasms, Adnexal and Skin Appendage / genetics. Skin Neoplasms / genetics. beta Catenin / genetics

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  • (PMID = 19384065.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / beta Catenin
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10. Manikandan R, Khafagy R, Reeve R, Agarwal M, Clarke NW: Male adnexal tumour of probable Wolffian duct origin. Scand J Urol Nephrol; 2005;39(6):520-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Male adnexal tumour of probable Wolffian duct origin.
  • Male adnexal tumours of Wolffian duct origin are very rare.
  • Histology revealed the lesion to be an adnexal tumour of probable Wolffian duct origin.
  • To our knowledge there have only been two previous cases of male adnexal tumour of Wolffian duct origin reported in the literature.

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  • (PMID = 16303731.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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11. Lee JH, Kyung MS, Jung US, Choi JS: Laparoscopic management of adnexal tumours in post-hysterectomy women. Aust N Z J Obstet Gynaecol; 2008 Feb;48(1):96-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic management of adnexal tumours in post-hysterectomy women.
  • BACKGROUND: Laparoscopy is becoming common for the management of complex benign gynaecological diseases, in which considerable adhesions are expected, thus making the laparoscopic surgery more difficult to perform.
  • AIMS: To evaluate the efficacy and safety of laparoscopic surgery for adnexal tumours in post-hysterectomy women.
  • METHODS: In a retrospective study, we reviewed and analysed 40 post-hysterectomy women who were treated surgically for benign ovarian tumours at Kangbuk Samsung Hospital, from May 1999 to April 2007.
  • CONCLUSIONS: Laparoscopic surgery for adnexal tumours in post-hysterectomy women might be an effective and safe alternative to laparotomic surgery.

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  • (PMID = 18275579.001).
  • [ISSN] 0004-8666
  • [Journal-full-title] The Australian & New Zealand journal of obstetrics & gynaecology
  • [ISO-abbreviation] Aust N Z J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / CA-19-9 Antigen
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12. Thamboo TP, Tan LH, Tan SY: Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors. J Cutan Pathol; 2006 Jan;33(1):27-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors.
  • Little is known about the expression of Bcl-x in cutaneous adnexal structures and benign cutaneous adnexal tumors.
  • METHODS: Tissues from 31 cases of benign cutaneous adnexal tumors (five trichofolliculomas, five trichoepitheliomas, two sebaceous adenomas, five apocrine hidradenomas, five eccrine poromas, five eccrine spiradenomas, and four syringomas) were immunostained for Bcl-x.
  • CONCLUSIONS: The degree of Bcl-x expression in cutaneous adnexal glandular structures appears to be related to their mode of secretion, being strongest in cells with apoptotic degradation of the entire cell (sebocytes).
  • This pattern is recapitulated in the corresponding benign cutaneous adnexal tumors.
  • Bcl-x may be useful in identifying cells with sebaceous differentiation in poorly differentiated adnexal tumors.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / metabolism. Skin / metabolism. Skin Neoplasms / metabolism. bcl-X Protein / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Epidermis / metabolism. Epidermis / pathology. Humans. Immunoenzyme Techniques. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Sweat Glands / metabolism. Sweat Glands / pathology

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  • (PMID = 16441408.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / bcl-X Protein
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13. Siddiqui NH, Wu SJ: Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexa-like differentiation mimicking mucoepidermoid carcinoma: a case report. Diagn Cytopathol; 2005 Apr;32(4):229-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexa-like differentiation mimicking mucoepidermoid carcinoma: a case report.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15754364.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Wimberger P, Kimmig R: [Significance of laparoscopy in gynaecological oncology: limitations for adnexal tumours]. Gynakol Geburtshilfliche Rundsch; 2009;49(3):133-7
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  • [Title] [Significance of laparoscopy in gynaecological oncology: limitations for adnexal tumours].
  • In the last few decades, the impact and use of laparoscopy for benign adnexal tumours have markedly increased.
  • This review evaluates the importance of laparoscopy in surgery of adnexa and especially of malignant tumours.
  • Certainly, morbidity after laparoscopy is lower, but there is a risk of possibly more restricted staging, rupture of the tumour and port metastases.
  • Analysis showed that the standard treatment of ovarian malignant tumours is laparotomy via a vertical incision, because data on laparoscopy are scarce and prospective, randomized trials for early-stage ovarian cancer are still missing.

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  • (PMID = 19525620.001).
  • [ISSN] 1423-0011
  • [Journal-full-title] Gynäkologisch-geburtshilfliche Rundschau
  • [ISO-abbreviation] Gynakol Geburtshilfliche Rundsch
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 24
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15. Alyahya GA, Stenman G, Persson F, Prause JU, Skjødt K, Saunte JP, Heegaard S: Pleomorphic adenoma arising in an accessory lacrimal gland of Wolfring. Ophthalmology; 2006 May;113(5):879-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma arising in an accessory lacrimal gland of Wolfring.
  • PURPOSE: To describe a patient with pleomorphic adenoma arising in an accessory lacrimal gland of Wolfring in the lower lid and to illustrate the immunohistochemical and molecular cytogenetics.
  • Histological, immunohistochemical, and fluorescence in situ hybridization studies of the excised tumor were performed.
  • The tumor was situated beneath an area of a normal accessory lacrimal gland of Wolfring and in close association with normal meibomian glands.
  • Myoepithelial tumor cells in the myxoid stroma reacted strongly with an antibody against glial fibrillary acidic protein, which did not bind to normal lacrimal gland tissue.
  • Tumor cells with both epithelial and myoepithelial morphologies reacted positively for both pleomorphic adenoma gene-1 and high-mobility group A2 proteins.
  • CONCLUSIONS: Pleomorphic adenoma of the accessory lacrimal gland is an exceedingly rare tumor of the ocular adnexa.
  • Glial fibrillary acidic protein seems to be a tumor-associated antigen.
  • Genetically, this case of pleomorphic adenoma arising from an accessory lacrimal gland of Wolfring is identical with those originating from salivary glands.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Eyelid Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 16530838.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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16. Dos Santos L, Garg K, Diaz JP, Soslow RA, Hensley ML, Alektiar KM, Barakat RR, Leitao MM Jr: Incidence of adnexal and lymph node metastases in endometrial stromal sarcoma. J Clin Oncol; 2009 May 20;27(15_suppl):5589

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  • [Title] Incidence of adnexal and lymph node metastases in endometrial stromal sarcoma.
  • : 5589 Background: To determine the incidence of adnexal and lymph node (LN) metastases in endometrial stromal sarcoma (ESS).
  • High-grade or undifferentiated tumors and ESS arising in extrauterine sites were excluded.
  • Adnexal metastases were identified in 8 (9.5%) of 84 cases.
  • All adnexal metastases were manifested by gross adnexal tumor and occurred in patients with other gross pelvic extrauterine disease.
  • In patients with gross pelvic extrauterine disease, adnexal metastasis did not affect survival.
  • The rate of adnexal metastasis appears to be negligible in the absence of gross adnexal and extrauterine tumor, but there may be a role for oophorectomy in the hormonal management of ESS.

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  • (PMID = 27962388.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Grey BR, Verma S, Maddineni SB, Lau MW, Clarke NW: Male adnexal tumour of wolffian origin: the first report of metastatic disease. Scand J Urol Nephrol; 2009;43(3):253-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Male adnexal tumour of wolffian origin: the first report of metastatic disease.
  • The first case of a male adnexal tumour of probable wolffian duct origin to develop metastatic disease is reported.
  • The characteristic histological appearance and immunohistochemical profiles of the primary and metastatic male tumours are discussed.

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  • (PMID = 18985546.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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18. Cangelosi JJ, Nash JW, Prieto VG, Ivan D: Cutaneous adnexal tumor with an unusual presentation--discussion of a potential diagnostic pitfall. Am J Dermatopathol; 2009 May;31(3):278-81
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  • [Title] Cutaneous adnexal tumor with an unusual presentation--discussion of a potential diagnostic pitfall.
  • The clinical presentation of skin adnexal tumors is nonspecific, and histologically; the differential diagnosis between primary cutaneous adnexal malignant carcinomas and metastatic tumors with a visceral origin can be challenging.
  • However, the tumor cells labeled strongly and diffusely not only for pancytokeratin and cytokeratin (CK7) but also with p63 and CK5/6; carcinoembryonic antigen highlighted the ductal structures.
  • Based on the p63 and CK5/6 positivity, the differential diagnosis also included the possibility of a primary adnexal neoplasm and a complete excision was advised.
  • The reexcision specimen revealed residual infiltrating dermal tumor and an overlying intraepithelial component with marked cytologic atypia and focal duct formation, diagnostic of a primary cutaneous adnexal tumor with ductal differentiation (porocarcinoma).
  • [MeSH-major] Biomarkers, Tumor / analysis. Diagnostic Errors / prevention & control. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Second Primary. Skin Neoplasms / pathology

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  • [CommentIn] Am J Dermatopathol. 2010 Dec;32(8):853-4 [20431390.001]
  • (PMID = 19384070.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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19. Kanitakis J: Adnexal tumours of the skin as markers of cancer-prone syndromes. J Eur Acad Dermatol Venereol; 2010 Apr;24(4):379-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adnexal tumours of the skin as markers of cancer-prone syndromes.
  • Adnexal tumours of the skin are benign, more rarely malignant, primary skin tumours that originate from, or differentiate towards, hair follicles, sebaceous and sweat glands.
  • Although they are usually encountered as single, sporadic tumours, they may occasionally be multiple, hereditary; in that case, they may herald complex genetic syndromes that comprise visceral cancers.
  • Dermatologists should be aware of these adnexal skin tumours, the diagnosis of which may contribute to an early detection of a cancer-prone syndrome with a potentially lethal outcome.
  • The main tumours falling into this category and their associated syndromes are reviewed here.
  • [MeSH-major] Epidermal Cyst / pathology. Muir-Torre Syndrome / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19744258.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers
  • [Number-of-references] 77
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20. Takeda A, Imoto S, Mori M, Nakano T, Nakamura H: Isobaric laparoendoscopic single-site assisted extracorporeal cystectomy in treatment of selected adnexal tumors: initial experience and technique. J Minim Invasive Gynecol; 2010 Nov-Dec;17(6):766-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isobaric laparoendoscopic single-site assisted extracorporeal cystectomy in treatment of selected adnexal tumors: initial experience and technique.
  • Herein, we describe our initial experience with isobaric (gasless) LESS-assisted extracorporeal cystectomy in management of selected adnexal tumors.
  • Of 17 consecutive adnexal tumors, 15 (88.2%) (dermoid cyst, 10; serous cystadenoma, 2; mucinous cystadenoma, 1; and paraovarian cyst, 2) were successfully managed with isobaric LESS-assisted extracorporeal cystectomy.
  • Two dermoid cysts required intracorporeal LESS cystectomy because of poor mobility of the adnexal tissue.
  • [MeSH-major] Adnexal Diseases / surgery. Gynecologic Surgical Procedures / methods. Laparoscopy / methods

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  • [Copyright] Copyright © 2010 AAGL. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20955986.001).
  • [ISSN] 1553-4669
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Heatley MK: Is female adnexal tumour of probable wolffian origin a benign lesion? A systematic review of the English literature. Pathology; 2009;41(7):645-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is female adnexal tumour of probable wolffian origin a benign lesion? A systematic review of the English literature.
  • AIMS: To establish the prognosis associated with female adnexal tumour of probable wolffian origin (FATWO) and determine the frequency with which it behaves as a truly benign lesion.
  • One patient with a ruptured tumour had recurrent disease and one other had died of disease (p = 0.2278).
  • There was no association between outcome and age (p = 0.6651), size (p = 0.1912), length of survival (p = 0.2351) tumour site, mitotic rate or necrosis (p = 0.5937, 0.4697 and 0.2016, respectively).
  • CONCLUSION: On the basis of these findings, FATWO cannot be regarded as a benign lesion.
  • [MeSH-major] Adnexa Uteri / pathology. Genital Neoplasms, Female / pathology. Wolffian Ducts / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Databases, Bibliographic. Disease-Free Survival. Female. Humans. Immunohistochemistry. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 20001344.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 48
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22. Lim MC, Kim TJ, Kang S, Bae DS, Park SY, Seo SS: Embryonic natural orifice transumbilical endoscopic surgery (E-NOTES) for adnexal tumors. Surg Endosc; 2009 Nov;23(11):2445-9
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  • [Title] Embryonic natural orifice transumbilical endoscopic surgery (E-NOTES) for adnexal tumors.
  • OBJECTIVE: To investigate the feasibility and surgical outcome of E-NOTES for adnexal tumors.
  • METHODS: We performed E-NOTES in 12 patients with adnexal tumors through a 2-cm intraumblical incision.
  • RESULTS: Since 1 July 2008, 12 patients have undergone E-NOTES for adnexal tumors.
  • CONCLUSION: E-NOTES is a feasible alternative method for resection of adnexal tumors with better cosmetic outcome.
  • [MeSH-minor] Adnexal Diseases / pathology. Adnexal Diseases / surgery. Adult. Feasibility Studies. Female. Follow-Up Studies. Humans. Korea. Middle Aged. Minimally Invasive Surgical Procedures / adverse effects. Minimally Invasive Surgical Procedures / methods. Ovariectomy / adverse effects. Ovariectomy / methods. Postoperative Complications / diagnosis. Postoperative Complications / epidemiology. Prospective Studies. Risk Assessment. Treatment Outcome. Umbilicus / surgery

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  • (PMID = 19343442.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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23. Takeda A, Sakai K, Mitsui T, Nakamura H: Management of large cystic adnexal tumor by gasless laparoscopic-assisted surgery with wound retractor. J Minim Invasive Gynecol; 2007 Sep-Oct;14(5):644-50
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  • [Title] Management of large cystic adnexal tumor by gasless laparoscopic-assisted surgery with wound retractor.
  • We used a retrospective analysis to evaluate the efficacy of a wound retractor used in gasless laparoscopic-assisted surgery by the subcutaneous abdominal wall-lift method for the management of large cystic adnexal tumors.
  • In the department of gynecology at a general hospital, 39 patients with large cystic adnexal tumors with an excised tissue weight including cystic contents exceeding 1000 g were treated by gasless laparoscopic-assisted surgery with a wound retractor from January 2001 through December 2006.
  • Intervention was with a gasless laparoscopic-assisted adnexal surgery with a wound retractor.
  • Histopathologic diagnosis of the excised tumor was mucinous cystadenoma, 18 cases; serous cystadenoma, 8 cases; mucinous cystadenocarcinoma of low-grade malignancy, 5 cases; dermoid cyst, 4 cases; paraovarian cyst, 2 cases; endometriotic cyst, 1 case; and clear cell adenocarcinoma, 1 case.
  • Bilateral adnexal tumors were noted in 3 cases.
  • We determined that gasless laparoscopic-assisted adnexal surgery with a wound retractor is an effective, minimally invasive procedure to treat large cystic adnexal tumors.

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  • (PMID = 17848329.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Krahl D, Sellheyer K: p75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology. Br J Dermatol; 2010 Jul;163(1):138-45
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  • [Title] p75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology.
  • BACKGROUND: Tumour development is frequently described in the basic pathology literature as a recapitulation of embryogenesis.
  • However, a link between the embryology of the skin and the histogenesis of adnexal tumours has been largely overlooked.
  • We therefore speculated that it is involved in the histogenesis of follicular adnexal tumours.
  • In contrast, the lack of p75NTR expression in morphoeic basal cell carcinoma favours a concept of this tumour as a more primitive follicular lesion with the characteristics of a carcinoma and not a hamartoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / metabolism. Hair Follicle / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Receptor, Nerve Growth Factor / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Merkel Cells / metabolism. Middle Aged. Skin / embryology. Skin / metabolism

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  • (PMID = 20184585.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptor, Nerve Growth Factor
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25. Harada O, Ota H, Takagi K, Matsuura H, Hidaka E, Nakayama J: Female adnexal tumor of probable wolffian origin: morphological, immunohistochemical, and ultrastructural study with c-kit gene analysis. Pathol Int; 2006 Feb;56(2):95-100
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  • [Title] Female adnexal tumor of probable wolffian origin: morphological, immunohistochemical, and ultrastructural study with c-kit gene analysis.
  • Female adnexal tumors of probable wolffian origin (FATWO) are rare neoplasms believed to originate from mesonephric (wolffian) remnants.
  • Although most cases follow a benign clinical course, approximately 10% of them either recur or metastasize and are thought to be resistant to chemoradiation therapy.
  • In 2004, imatinib therapy, a tyrosine kinase inhibitor known to be effective against gastrointestinal stromal tumors, was reported to be effective also in a case of KIT-positive FATWO.
  • The tumor had typical characteristics of FATWO in both morphology and immunohistochemistry.
  • In addition, the cytological features of this rare tumor are presented, which have not been described previously.
  • [MeSH-major] Adnexa Uteri. Genital Neoplasms, Female / diagnosis. Mesonephros / pathology. Proto-Oncogene Proteins c-kit / genetics
  • [MeSH-minor] Adnexal Diseases / diagnosis. Adnexal Diseases / metabolism. Adnexal Diseases / pathology. DNA, Neoplasm / analysis. DNA, Neoplasm / genetics. Exons / genetics. Female. Humans. Immunohistochemistry. Keratins / analysis. Magnetic Resonance Imaging. Microscopy, Electron. Middle Aged. Mutation. Vimentin / analysis

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  • (PMID = 16445822.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Vimentin; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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26. Auw-Hädrich C, Göbel N, Illerhaus G: [Infectious agents in ocular adnexal tumours]. Klin Monbl Augenheilkd; 2010 Jul;227(7):530-7
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  • [Title] [Infectious agents in ocular adnexal tumours].
  • In recent years, infectious agents have been increasingly recognised as an important pathogenetic factor for various malignant tumours of the ocular adnexa.
  • Ocular adnexal lymphoma (OAL), especially extranodal marginal cell lymphoma, is associated with Chlamydophila psittaci and Helicobacter pylori in certain geographic regions.
  • Kaposi sarcoma rarely occurs at the ocular adnexa in HIV-positive individuals and seems to be associated with Kaposi sarcoma-associated Herpes virus (KSHV) or HHV8.

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  • [Copyright] Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 20535664.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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27. Czekierdowski A, Stachowicz N, Smoleń A, Kotarski J: [The use of 2-dimensional and 3-dimensional color and power-Doppler in the diagnosis of blood flow indices of adnexal tumors]. Ginekol Pol; 2006 Apr;77(4):296-306
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  • [Title] [The use of 2-dimensional and 3-dimensional color and power-Doppler in the diagnosis of blood flow indices of adnexal tumors].
  • OBJECTIVES: The purpose of this study was to compare 2-dimensional and 3-dimensional color and power-Doppler as measured with blood flow indices for the prediction of malignancy in complex adnexal masses.
  • METHODS: Two hundred eighty women with complex adnexal masses (mean age, 46,3 years (range, 13-83 years) were evaluated by 2-dimensional and 3-dimensional power-Doppler imaging.
  • Complex adnexal mass was defined as the presence of at least one of the following features: solid areas, thick papillary projections, thick septa, or purely solid echogenicity.
  • Tumor volume, sonomorphology and Doppler indices (PI, RI), as well 3-dimensional power-Doppler assessment (VI, FI, VFI) were calculated.
  • All tumors were surgically removed and definitive histological diagnosis was obtained in each case.
  • RESULTS: Seventy one tumors (25.3%) were proved to be malignant, and 209 tumors (74.7%) were proved to be benign.
  • Statistically significant differences between benign and malignant tumors were found for PI (1.06 vs 0.76; p = 0.001), RI (0.62 vs 0.51; p = 0.002), VI (0.55 vs 1.52; p = 0.002) oraz VFI (0.18 vs 0.49; p = 0.001).
  • However, the highest sensitivity of 3D indices for malignant tumor detection was found for FI (42.9%).
  • AUROC's analysis indicated that the most useful test for the discrimination between benign and malignant tumors was VI followed by VFI and PI with RI.
  • CONCLUSION: Three-dimensional power-Doppler imaging has diagnostic potential for the discrimination of benign and malignant complex adnexal masses, but specific, possibly most vascularised areas of each tumor have to be examined in detail to improve not yet satisfactory predictive values of this method.
  • [MeSH-major] Genital Neoplasms, Female / ultrastructure. Imaging, Three-Dimensional. Neoplasms, Adnexal and Skin Appendage / diagnostic imaging. Neovascularization, Pathologic / diagnostic imaging. Ultrasonography, Doppler
  • [MeSH-minor] Adnexal Diseases / diagnostic imaging. Adolescent. Adult. Aged. Aged, 80 and over. Blood Flow Velocity. Diagnosis, Differential. Female. Humans. Middle Aged. ROC Curve. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16875035.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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28. dos Santos VM, Marques HV Jr, Lima Cdo C, Turra TZ, de Melo Nogueira PR Jr, Lima LN: Yellow nail syndrome and adnexal tumour: causal or casual association? Indian J Chest Dis Allied Sci; 2010 Jan-Mar;52(1):51-3
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  • [Title] Yellow nail syndrome and adnexal tumour: causal or casual association?
  • In Brazil as well as in India, this syndrome has been scarcely described, at least in part due to diagnosis pitfalls related with darker skin pigmentation.
  • A case of adnexal malignancy developing several decades after initial signs of yellow nail syndrome is reported in a 61-year-old Brazilian female admitted for evaluation of peripheral oedema.
  • Physical examination showed yellow thickened nails and lower limb oedema, and a painless huge adnexal mass.
  • Diverse tumours have been described associated with yellow nail syndrome; however, associations can also occur by chance.

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  • (PMID = 20364616.001).
  • [ISSN] 0377-9343
  • [Journal-full-title] The Indian journal of chest diseases & allied sciences
  • [ISO-abbreviation] Indian J Chest Dis Allied Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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29. Torres A, Torres K, Paszkowski T, Staśkiewicz G, Maciejewski R, Woźniakowska E, Zaleska W: [Concentration of TNF-alpha in the postoperative period in patients with benign adnexal tumors treated by laparoscopy or laparotomy]. Ginekol Pol; 2007 Oct;78(10):764-7
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  • [Title] [Concentration of TNF-alpha in the postoperative period in patients with benign adnexal tumors treated by laparoscopy or laparotomy].
  • OBJECTIVES: The aim of the study was to compare serum concentrations of the TNF-alpha (TNF-alpha) in the early postoperative period in patients with benign adnexal masses operated by laparoscopy or laparotomy.
  • MATERIAL AND METHODS: The study was conducted in a group of patients aged from 20 to 52, operated due to adnexal masses.
  • CONCLUSIONS: Lower concentrations of TNF-alpha in the laparoscopy group, observed 24 hours after the operation, may reflect more favorable changes in the systemic inflammatory response after minimally invasive management of benign ovarian masses.
  • [MeSH-major] Biomarkers, Tumor / blood. Laparoscopy. Laparotomy. Ovarian Diseases / blood. Ovarian Diseases / surgery. Postoperative Period. Tumor Necrosis Factor-alpha / blood
  • [MeSH-minor] Adnexal Diseases / blood. Adnexal Diseases / surgery. Adult. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasms, Adnexal and Skin Appendage / blood. Neoplasms, Adnexal and Skin Appendage / diagnosis. Neoplasms, Adnexal and Skin Appendage / surgery. Ovarian Neoplasms / blood. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18200965.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Necrosis Factor-alpha
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30. Timmerman D, Van Calster B, Jurkovic D, Valentin L, Testa AC, Bernard JP, Van Holsbeke C, Van Huffel S, Vergote I, Bourne T: Inclusion of CA-125 does not improve mathematical models developed to distinguish between benign and malignant adnexal tumors. J Clin Oncol; 2007 Sep 20;25(27):4194-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inclusion of CA-125 does not improve mathematical models developed to distinguish between benign and malignant adnexal tumors.
  • PURPOSE: To test the value of serum CA-125 measurements alone or as part of a multimodal strategy to distinguish between malignant and benign ovarian tumors before surgery based on a large prospective multicenter study (International Ovarian Tumor Analysis).
  • PATIENTS AND METHODS: Patients with at least one persistent ovarian mass preoperatively underwent transvaginal ultrasonography using gray scale imaging to assess tumor morphology and color Doppler imaging to obtain indices of blood flow.
  • RESULTS: Data from 809 patients recruited from nine centers were included in the analysis; 567 patients (70%) had benign tumors and 242 (30%) had malignant tumors-of these 152 were primary invasive (62.8%), 52 were borderline malignant (21.5%), and 38 were metastatic (15.7%).
  • Results were very similar when the models were prospectively tested on a group of 345 new patients with adnexal masses of whom 126 had malignant tumors (37%).
  • CONCLUSION: Adding information on CA-125 to clinical information and ultrasound information does not improve discrimination of mathematical models between benign and malignant adnexal masses.
  • [MeSH-major] Adnexal Diseases / blood. Adnexal Diseases / diagnosis. Antigens, Neoplasm / blood. CA-125 Antigen / biosynthesis. Ovarian Neoplasms / blood. Ovarian Neoplasms / diagnosis

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  • [CommentIn] J Clin Oncol. 2008 Jan 20;26(3):512; author reply 513 [18202431.001]
  • [CommentIn] J Clin Oncol. 2007 Sep 20;25(27):4159-61 [17698803.001]
  • (PMID = 17698805.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CA-125 Antigen
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31. Cauchi C, Visca P, Donati P, Lopez M: [Skin adnexal tumors]. Clin Ter; 2006 Jul-Aug;157(4):363-76

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Skin adnexal tumors].
  • Adnexal skin tumors are rare neoplasms that develop from hair follicles, sebaceous glands and sweat glands.
  • In the majority of cases these tumors are benign, although metastases have been reported in rare occasion.
  • The diagnosis in always histologic and often it is sufficient to report the lesion simply as benign or malignant.
  • When the tumor is large, the Mohs technique can be used.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 17051975.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 104
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32. Fujiwara M, Taube J, Sharma M, McCalmont TH, Kim J: PAX8 discriminates ovarian metastases from adnexal tumors and other cutaneous metastases. J Cutan Pathol; 2010 Sep;37(9):938-43
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  • [Title] PAX8 discriminates ovarian metastases from adnexal tumors and other cutaneous metastases.
  • BACKGROUND: The distinction of metastatic ovarian carcinoma from other metastatic carcinomas and primary adnexal lesions in the skin is often difficult.
  • METHODS: PAX8 immunohistochemical analysis was performed on 24 cases of metastatic adenocarcinomas to the skin and compared with 7 cases of primary adnexal lesions and also compared with p63 immunohistochemical staining results.
  • Patients with metastatic adenocarcinomas had clinically documented primary malignancies, and patients with primary adnexal carcinomas had no known history of another adenocarcinoma.
  • PAX8 immunohistochemical staining in primary adnexal and other cutaneous metastases was completely negative (0/7 and 0/16, respectively).
  • The p63 expression profile supported the distinction between adnexal and metastatic adenocarcinomas.
  • PAX8 expression is a useful marker that effectively discriminated metastatic ovarian carcinomas from metastatic breast carcinomas and primary adnexal tumors.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / diagnosis. Ovarian Neoplasms / diagnosis. Paired Box Transcription Factors / metabolism. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 20492080.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / PAX8 protein, human; 0 / Paired Box Transcription Factors
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33. Smoleń A, Stachowicz N, Czekierowski A, Kotarski J: [The estimation of the probability of tumor malignacy on the basis of test combination in the primary diagnosis of adnexal tumors]. Ginekol Pol; 2010 Apr;81(4):254-61
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  • [Title] [The estimation of the probability of tumor malignacy on the basis of test combination in the primary diagnosis of adnexal tumors].
  • PURPOSE: The aim was to evaluate the risk of ovarian tumor malignancy based on logistic regression analysis and to construct a practical tool which might be used at the bedside.
  • MATERIAL AND METHODS: 379 women with adnexal masses were enrolled to the study The results of the two-dimensional (2D) gray-scale ultrasound examination, color and spectral Doppler blood flow measurement, three-dimensional (3D) sonoangiography examination and serum levels of CA-125 measurement were analyzed.
  • 160 out of 379 women with abnormal findings, (42.2%), were diagnosed with a malignant ovarian tumor and 219 (57.8%) were found to have a non-malignant adnexal mass.
  • Furthermore, the nomograms applicable at the bedside for estimation of the probability of malignancy for the examined adnexal tumor were derived.
  • CONCLUSIONS: The results of the study suggest that the combined use of ultrasound parameters and serum level of CA-125 in the prognostic model improves the diagnostic precision in the primary discrimination of benign and malignant ovarian tumors in women.


34. Takeda A, Imoto S, Mori M, Nakano T, Nakamura H: Wound retraction system for isobaric laparoendoscopic single-site surgery to treat adnexal tumors: pilot study. J Minim Invasive Gynecol; 2010 Sep-Oct;17(5):626-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Wound retraction system for isobaric laparoendoscopic single-site surgery to treat adnexal tumors: pilot study.
  • Fourteen isobaric LESS adnexal surgeries including 1 emergency procedure with adnexal torsion were performed using multiple instruments inserted through the wound retractor.
  • A wound retractor offers safe and reliable access for isobaric LESS adnexal surgery as an alternative to the current specialized port systems.

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  • [Copyright] Copyright © 2010 AAGL. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20579942.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Bazot M, Nassar-Slaba J, Thomassin-Naggara I, Cortez A, Uzan S, Daraï E: MR imaging compared with intraoperative frozen-section examination for the diagnosis of adnexal tumors; correlation with final histology. Eur Radiol; 2006 Dec;16(12):2687-99
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  • [Title] MR imaging compared with intraoperative frozen-section examination for the diagnosis of adnexal tumors; correlation with final histology.
  • The aim was to compare the accuracy of magnetic resonance imaging (MRI) and intraoperative consultation (IC) for the diagnosis of adnexal masses, with reference to final histology.
  • MRI was performed in 136 women with sonographically indeterminate adnexal masses.
  • All masses were characterized as benign or malignant according to previously published MR imaging and histopathologic criteria.
  • Histology revealed 168 adnexal masses (99 benign, 23 borderline and 46 invasive).
  • Among the 151 adnexal masses studied by both MRI and IC, respective sensitivities, specificities, positive and predictive values of both methods for the diagnosis of malignancy were 89.7% and 84.5%, 91.4% and 100%, 86.7% and 100%, and 93.4% and 91.3%.
  • Sensitivities of MR imaging and frozen section for the diagnosis of serous versus mucinous borderline tumors were 33.3% and 93.3%, and 62.5% and 12.5%, respectively.
  • MRI is less accurate than IC for characterizing adnexal masses.
  • However, MRI may increase the relevance of IC for borderline mucinous tumors.
  • [MeSH-major] Adnexa Uteri / pathology. Magnetic Resonance Imaging / methods. Ovarian Neoplasms / diagnosis

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  • (PMID = 16547708.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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36. Nikolić B, Ardalić D, Lazić J: [Tumor marker CA-125 in adnexal inflammatory tumors]. Vojnosanit Pregl; 2006 Apr;63(4):383-5
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  • [Title] [Tumor marker CA-125 in adnexal inflammatory tumors].
  • BACKGROUND/AIM: The glycoprotein of a high molecular weight CA-125, which is not a specific tumor marker of ovarian cancer, is secreted by the endothelial cells of most pelvic organs.
  • METHODS: The study included 57 female patients hospitalized due to inflammable adnexal tumors.
  • In all the 57 patients, transvaginal Doppler ultrasonography revealed the presence of adnexal tumor of inflammatory kind.
  • CONCLUSION: The method for the assessment of CA-125 is simple and available which facilitates the monitoring of surgical, conservative or the combined therapy that is particularly significant in younger patients with inflammable adnexal tumor developed on the basis of endometrosis.
  • [MeSH-major] Biomarkers, Tumor / analysis. CA-125 Antigen / analysis. Fallopian Tube Neoplasms / diagnosis. Ovarian Neoplasms / diagnosis

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  • (PMID = 16683407.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen
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37. Ivan D, Nash JW, Prieto VG, Calonje E, Lyle S, Diwan AH, Lazar AJ: Use of p63 expression in distinguishing primary and metastatic cutaneous adnexal neoplasms from metastatic adenocarcinoma to skin. J Cutan Pathol; 2007 Jun;34(6):474-80
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  • [Title] Use of p63 expression in distinguishing primary and metastatic cutaneous adnexal neoplasms from metastatic adenocarcinoma to skin.
  • p63, a recently identified homologue of the p53 gene, is mainly expressed by basal and myoepithelial cells in skin.
  • Others and we have shown the value of p63 in distinguishing primary adnexal tumors from visceral adenocarcinomas metastatic to skin.
  • We now investigate the pattern of p63 expression in metastases from skin adnexal carcinomas and their cognate primaries and evaluate p63 expression in a larger case series of malignant cutaneous adnexal neoplasms.
  • Immunohistochemical analysis for p63 was performed on 13 metastases of adnexal carcinomas and their corresponding primary tumors.
  • Twenty visceral metastatic adenocarcinomas to the skin and 7 primary mucinous carcinomas with cutaneous or visceral origin were compared.
  • The majority (90.9%) of primary adnexal tumors strongly expressed p63 and their metastases labeled similar to their cognate primary tumors.
  • Analysis of p63 expression may assist in the differential diagnosis of primary adnexal carcinomas versus metastatic visceral adenocarcinomas to the skin.
  • Metastases from adnexal carcinomas generally retain p63 expression similar to their associated primary tumors.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Biomarkers, Tumor / metabolism. DNA-Binding Proteins / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Skin Neoplasms / metabolism. Trans-Activators / metabolism. Tumor Suppressor Proteins / metabolism

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  • [CommentIn] J Cutan Pathol. 2008 Jul;35(7):692-3 [18312438.001]
  • (PMID = 17518775.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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38. Jain V, Agarwal T, Sharma V, Bisht D, Agarwal AK: Female adnexal tumour of probable Wolffian origin. Indian J Pathol Microbiol; 2007 Oct;50(4):806-8

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  • [Title] Female adnexal tumour of probable Wolffian origin.
  • Mass on histopathological examination was proved to be tumor of Wolffian origin.
  • [MeSH-major] Adnexal Diseases / diagnosis. Adnexal Diseases / pathology. Neoplasms / diagnosis. Neoplasms / pathology. Wolffian Ducts / pathology

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  • (PMID = 18306563.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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39. Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L: Simple ultrasound-based rules for the diagnosis of ovarian cancer. Ultrasound Obstet Gynecol; 2008 Jun;31(6):681-90
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  • OBJECTIVE: To derive simple and clinically useful ultrasound-based rules for discriminating between benign and malignant adnexal masses.
  • METHODS: In a multicenter study involving nine centers consecutive patients with persistent adnexal tumors underwent transvaginal gray-scale and Doppler ultrasound examination using a standardized examination technique and standardized terms and definitions.
  • When developing simple ultrasound-based rules to predict malignancy (M-rules) we chose the ultrasound variable or the combination of ultrasound variables that had the highest positive predictive value (PPV) with regard to malignancy; when developing simple rules to predict a benign tumor (B-rules) we chose the ultrasound variable or the combination of ultrasound variables that had the lowest PPV with regard to malignancy.
  • We selected ten rules that were in agreement with our clinical experience and were applicable to at least 30 tumors and then tested them prospectively on 507 tumors examined in three of the nine centers.
  • RESULTS: 1066 patients with 1233 adnexal tumors were included.
  • There were 903 benign tumors (73%) and 330 malignant tumors (27%).
  • In 167 patients the tumors were bilateral.
  • (1) irregular solid tumor;. (2) ascites;.
  • (4) irregular multilocular-solid tumor with a largest diameter of at least 100 mm; and (5) very high color content on color Doppler examination.
  • We chose five simple rules to suggest a benign tumor (B-rules):.
  • (4) smooth multilocular tumor less than 100 mm in largest diameter; and (5) no detectable blood flow on Doppler examination.
  • These ten rules were applicable to 76% of all tumors, where they resulted in a sensitivity of 93%, specificity of 90%, positive likelihood ratio (LR+) of 9.45 and negative likelihood ratio (LR-) of 0.08.
  • When prospectively tested the rules were applicable in 76% (386/507) of the tumors, where they had a sensitivity of 95% (106/112), a specificity of 91% (249/274), LR+ of 10.37, and LR- of 0.06.
  • CONCLUSION: Most adnexal tumors in an ordinary tumor population can be correctly classified as benign or malignant using simple ultrasound-based rules.
  • For tumors that cannot be classified using simple rules, ultrasound examination by an expert examiner might be useful.
  • [MeSH-major] Adnexa Uteri / ultrasonography. Adnexal Diseases / ultrasonography. Algorithms. Ovarian Neoplasms / ultrasonography. Ultrasonography, Doppler, Color / methods

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  • (PMID = 18504770.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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40. Ameye L, Valentin L, Testa AC, Van Holsbeke C, Domali E, Van Huffel S, Vergote I, Bourne T, Timmerman D: A scoring system to differentiate malignant from benign masses in specific ultrasound-based subgroups of adnexal tumors. Ultrasound Obstet Gynecol; 2009 Jan;33(1):92-101
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  • [Title] A scoring system to differentiate malignant from benign masses in specific ultrasound-based subgroups of adnexal tumors.
  • OBJECTIVE: To investigate if the prediction of malignant adnexal masses can be improved by considering different ultrasound-based subgroups of tumors and constructing a scoring system for each subgroup instead of using a risk estimation model applicable to all tumors.
  • METHODS: We used a multicenter database of 1573 patients with at least one persistent adnexal mass.
  • The sensitivity and specificity, with regard to the prediction of malignancy, of the scoring system were compared with that of the subjective evaluation of ultrasound images by an experienced examiner (pattern recognition) and with that of a published logistic regression (LR) model for the calculation of risk of malignancy in adnexal masses.
  • The gold standard was the pathological classification of the mass as benign or malignant (borderline, primary invasive, or metastatic).
  • [MeSH-major] Adnexa Uteri / ultrasonography. Adnexal Diseases / ultrasonography. Genital Neoplasms, Female / ultrasonography

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  • [Copyright] Copyright (c) 2008 ISUOG.
  • (PMID = 19090501.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] England
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41. Veyer L, Marret H, Bleuzen A, Simon E, Body G, Tranquart F: Preoperative diagnosis of ovarian tumors using pelvic contrast-enhanced sonography. J Ultrasound Med; 2010 Jul;29(7):1041-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative diagnosis of ovarian tumors using pelvic contrast-enhanced sonography.
  • OBJECTIVE: The purpose of this study was to assess the feasibility of using a contrast agent for the sonographic examination of adnexal tumors and identify discriminating parameters in the preoperative diagnosis of malignant tumors.
  • RESULTS: Fifty-two tumors were analyzed.
  • Morphologic and Doppler criteria analyses were conducted as described in the literature.
  • When borderline tumors were eliminated, there was an inversion of this, with an AUC of 0.85 versus 0.73.
  • The inclusion of contrast results in the examiner's diagnosis in the context of a bivariate model comparing malignant and borderline tumors with benign tumors provided an AUC of 0.88.
  • CONCLUSIONS: Contrast-enhanced sonography improves preoperative diagnosis of ovarian tumors parameters.
  • The significant parameters of the enhancement curve were significantly different for malignant and benign tumors.
  • Borderline tumors contribute to a reduction of the discriminating capacity of the contrast agent.

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  • (PMID = 20587427.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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42. Flores-Alvarez E, Tello-Brand SE, López-López F, Rivera-Barragán V: Peritoneal tuberculosis. Report of seven cases. Cir Cir; 2010 Jan-Feb;78(1):67-71
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  • The most frequent clinical data were abdominal pain (six patients), ascites (four patients), and abdominal tumor (three patients).
  • Abdominopelvic CT examinations revealed unilateral ovarian tumor in four patients, bilateral ovarian tumor in two patients, ascites in four patients, and retroperitoneal adenopathy in one patient.
  • All patients had a preoperative diagnosis of malignant tumor.
  • Diagnoses should be considered in all patients with ascites, adnexal tumors and elevated serum CA-125 levels.

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  • (PMID = 20226130.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Antitubercular Agents; 0 / Biomarkers; 0 / CA-125 Antigen
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43. Lu NH, Tseng MJ: Laparoscopic management of tailgut cyst: case report and review of literature. J Minim Invasive Gynecol; 2010 Nov-Dec;17(6):802-4
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  • It is usually asymptomatic or demonstrates mass effects, and preoperatively is frequently misdiagnosed as adnexal tumor.
  • The English-language literature contains only limited reports of the laparoendoscopic approach to retrorectal cystic tumor and tailgut cyst.

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  • [Copyright] Crown Copyright © 2010. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20955994.001).
  • [ISSN] 1553-4669
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Garcia-Bonafe MM, Campins MM, Redecilla PH: Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol; 2009 Sep-Oct;53(5):576-80
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  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant adnexal tumor of the eccrine sweat glands.
  • The histology is similar to that of benign nodular hidradenoma, but MNH shows an infiltrative and invasive pattern, necrosis and angiolymphatic invasion.
  • CONCLUSION: Rapid, accurate diagnosis of these tumors is important, particularly when they develop at sites where a metastatic process must be ruled out.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Biopsy, Fine-Needle. Head and Neck Neoplasms / pathology. Scalp / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19798887.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Kini JR, Kini H: Fine-needle aspiration cytology in the diagnosis of malignant proliferating trichilemmal tumor: Report of a case and review of the literature. Diagn Cytopathol; 2009 Oct;37(10):744-7
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  • [Title] Fine-needle aspiration cytology in the diagnosis of malignant proliferating trichilemmal tumor: Report of a case and review of the literature.
  • Malignant proliferating trichilemmal tumor is a rare cutaneous neoplasm derived from the outer root sheath of the hair follicle.
  • Fine-needle aspiration cytology is being increasingly used in the investigation of primary and metastatic cutaneous tumors.
  • However, there are few reports on the cytology of trichilemmal tumors in the literature.
  • We describe the cytological features of this uncommon adnexal tumor presenting as a scalp mass in a 58-year-old woman.
  • [MeSH-major] Hair Diseases / pathology. Hair Follicle / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19405112.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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46. Bartos P, Struppl D, Trhlík M, Czudek S, Skrovina M, Adamcík L, Soumarová R: [Da vinci robotic surgery in gynaecological oncology: a critical interim appraisal]. Ceska Gynekol; 2007 Oct;72(5):354-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • DESIGN: Prospective study analysing our experience in 10 patients operated due to gynaecological malignancy, adnexal tumors or planned for the procedure used as a part of extensive oncological surgery.
  • 2 patients with early invasive cervical cancer, 2 patients with cervical cancer in situ (CIS), 3 patients with complex ovarian tumors, 2 patients with symptomatic atypical endometrial glandular hyperplasia and 1 patient underwent necessary gynecological surgery as a part of oncological treatment of breast cancer.

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  • (PMID = 18175521.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] CZE
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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47. Ding DC, Hsu S: Lipid cell tumor in an adolescent girl: a case report. J Reprod Med; 2007 Oct;52(10):956-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipid cell tumor in an adolescent girl: a case report.
  • BACKGROUND: Lipid cell tumors of the ovary are rare sex cord neoplasms and account for < 0.1% of ovarian tumors.
  • Ultrasonography revealed an echogenic left adnexal tumor about 5.7 x 6.3 x 5.5 cm.
  • The patient underwent laparoscopic ovarian cystectomy, and pathology showed a lipid cell tumor.
  • CONCLUSION: The tumor appeared to be the source of hyperandrogenism in this woman.
  • [MeSH-major] Amenorrhea / etiology. Ovarian Neoplasms / complications. Sex Cord-Gonadal Stromal Tumors / complications. Virilism / etiology

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  • (PMID = 17977174.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone
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48. Blasini W, Hu S, Gugic D, Vincek V: Papillary eccrine adenoma in association with cutaneous horn. Am J Clin Dermatol; 2007;8(3):179-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary eccrine adenoma in association with cutaneous horn.
  • Papillary eccrine adenoma (PEA) is an uncommon sweat gland neoplasm that occurs more frequently on the distal extremities of Black women.
  • Concurrent occurrence of PEA and HPV-like epidermal changes may be coincidental; however, their co-occurrence may also be related to the environment induced by this adnexal tumor.
  • [MeSH-major] Adenoma / complications. Keratosis / complications. Sweat Gland Neoplasms / complications

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  • (PMID = 17492846.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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49. Alex G: Apocrine adenocarcinoma of the nipple: a case report. Cases J; 2008;1(1):88

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Apocrine adenocarcinomas are rare malignant skin adnexal tumours.

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  • [Cites] Dermatol Online J. 2008;14(6):5 [18713586.001]
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  • (PMID = 18700029.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2526981
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50. Zaraa I, Zeglaoui F, Fazaa B, Ezzine N, Elfekih N, Zermani R, Ben Jilani S, Kamoun MR: [Brooke-Spiegler syndrome]. Tunis Med; 2006 Sep;84(9):578-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Syndrome de brooke-Spiegler.
  • Brooke Spiegler syndrome is a rare genodermatosis characterized by an association of multiple trichoepitheliomas and cylindromas, sometimes accompanied by other adnexal tumors (spiradenoma, mila), we report two family cases of Brooke Spiegler syndrome.
  • No neoplastic tumor was identified.
  • A co-existence of adnexal tumors was found in the other members of the family.
  • Brooke Spiegler syndrome is an autosomial dominant disease with variable penetrance, it's characterized by a family history of trichoepitheliomas, with other adnexal tumors.
  • Brooke Spiegler syndrome is usually a benign disease, but patients with this syndrome should be explored for malignancy.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics

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  • (PMID = 17263207.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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51. Zhang J, Stirling B, Temmerman ST, Ma CA, Fuss IJ, Derry JM, Jain A: Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. J Clin Invest; 2006 Nov;116(11):3042-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cylindromatosis (CYLD) is a deubiquitinating enzyme that is altered in patients with familial cylindromatosis, a condition characterized by numerous benign adnexal tumors.
  • CYLD-deficient mice were more susceptible to induced colonic inflammation and showed a dramatic increase in the incidence of tumors compared with controls in a colitis-associated cancer model.

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  • (PMID = 17053834.001).
  • [ISSN] 0021-9738
  • [Journal-full-title] The Journal of clinical investigation
  • [ISO-abbreviation] J. Clin. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Intracellular Signaling Peptides and Proteins; 0 / NEMO protein, mouse; 0 / NF-kappa B; 0 / TNF Receptor-Associated Factor 2; 0 / Ubiquitin; EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases; EC 3.1.2.15 / CYLD protein, mouse; EC 3.4.22.- / Cysteine Endopeptidases
  • [Other-IDs] NLM/ PMC1616194
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52. Bats AS, Larousserie F, Le Frère-Belda MA, Metzger U, Lécuru F: Usefulness of routine intraoperative staging of suspicious adnexal tumours: illustration by two cases of adult granulosa cell tumour. Eur J Gynaecol Oncol; 2010;31(2):206-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Usefulness of routine intraoperative staging of suspicious adnexal tumours: illustration by two cases of adult granulosa cell tumour.
  • Granulosa cell tumours (GCTs) account for less than 3% of all ovarian malignancies but are among the most common sex cord-stromal tumours.
  • Symptoms related to oestrogen production by the tumour may occur.
  • [MeSH-major] Granulosa Cell Tumor / pathology. Gynecologic Surgical Procedures / methods. Neoplasm Staging / methods. Ovarian Neoplasms / pathology

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  • (PMID = 20527242.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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53. Schanz A, Richter J, Beyer I, Baldus SE, Hess AP, Kruessel JS: Genital schistosomiasis as a cause of female sterility and acute abdomen. Fertil Steril; 2010 Apr;93(6):2075.e7-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To report the case of a Nigerian patient who suffered from sterility and underwent abdominal laparotomy to remove an adnexal tumor.
  • PATIENTS: One patient who underwent an abdominal laparotomy to remove an adnexal tumor.
  • INTERVENTION(S): In vitro fertilization and adnexal tumor resection via laparotomy.
  • MAIN OUTCOME MEASURE(S): Treatment of the adnexal tumor affecting the reproductive health.

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  • [Copyright] Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20138271.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Lee PL, Lourduraj LT, Palko MJ 3rd, Jukic DM, English JC 3rd: Hereditary basaloid follicular hamartoma syndrome. Cutis; 2006 Jul;78(1):42-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Basaloid follicular hamartoma syndrome (BFHS) is a rare adnexal tumor genodermatosis.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Facial Dermatoses / diagnosis. Hamartoma / diagnosis. Hand Dermatoses / diagnosis. Skin Diseases / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentIn] Cutis. 2007 Feb;79(2):154; author reply 155-6 [17388219.001]
  • (PMID = 16903320.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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55. Kazakov DV, Kutzner H, Mukensnabl P, Michal M: Low-grade adnexal carcinoma of the skin with multidirectional (glandular, trichoblastomatous, spiradenocylindromatous) differentiation. Am J Dermatopathol; 2006 Aug;28(4):341-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low-grade adnexal carcinoma of the skin with multidirectional (glandular, trichoblastomatous, spiradenocylindromatous) differentiation.
  • The conjoint occurrence of follicular, sebaceous, or apocrine differentiations in a cutaneous adnexal neoplasm is a known event, more often encountered in benign neoplasms, whereas reports of cutaneous malignant adnexal tumors with bilineage or trilineage differentiation are few.
  • A new case of a cutaneous malignant adnexal neoplasm with multidirectional differentiation is reported here.
  • A 57-year-old woman presented with a long-standing, slowly growing, asymptomatic solitary tumor the size of a large nut in the coccygeal area, which was surgically excised.
  • We classified this tumor as a well-differentiated adnexal carcinoma demonstrating combined follicular and apocrine differentiation.
  • It differs from previously published cases of malignant adnexal tumors with multidirectional differentiation and further exemplifies the spectrum of diversity encountered in malignant proliferations with differentiation toward the folliculosebaceous-apocrine unit.
  • [MeSH-major] Adnexal Diseases / pathology. Cell Differentiation. Skin Neoplasms / pathology

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  • (PMID = 16871040.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Canedo T, de Almeida MP, Cuzzi T, Ramos-e-Silva M: Immunophenotypic aspects of cylindroma and nodular hidradenoma. J Eur Acad Dermatol Venereol; 2010 Feb;24(2):178-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Some adnexal tumours have many controversies about their histogenesis.
  • In five of seven cases of nodular hidradenoma (clear cell), we could easily observe clear cells between 20% and 50% of tumour cells.
  • The positivity for p63 antibody, nuclear pattern, was observed in six of seven cases, in the major part of tumour cells.
  • Limitation Samples are in small number because these are relatively rare tumours.
  • CONCLUSIONS: The present study suggests eccrine origin for both tumours: cylindroma and clear cell hidradenoma.

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  • (PMID = 19796089.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD15; 0 / CKAP4 protein, human; 0 / Membrane Proteins
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57. Kalof AN, Cooper K: D2-40 immunohistochemistry--so far! Adv Anat Pathol; 2009 Jan;16(1):62-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • More recently, D2-40 immunoexpression has been reported in primary adrenal cortical tumors, schwannomas, and adnexal tumors of the skin.
  • [MeSH-major] Antibodies, Monoclonal. Biomarkers, Tumor / analysis

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  • (PMID = 19098468.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
  • [Number-of-references] 14
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58. Liang H, Wu H, Giorgadze TA, Sariya D, Bellucci KS, Veerappan R, Liegl B, Acs G, Elenitsas R, Shukla S, Youngberg GA, Coogan PS, Pasha T, Zhang PJ, Xu X: Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin. Am J Surg Pathol; 2007 Feb;31(2):304-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin.
  • Distinction of primary skin adnexal carcinomas from cutaneous metastasis of adenocarcinomas is challenging.
  • In this study, we evaluated podoplanin immunoreactivity in a series of primary skin adnexal tumors and adenocarcinomas metastatic to skin using a D2-40 antibody.
  • The initial test series were composed of a total of 93 cases including 32 primary skin adnexal carcinomas, 46 benign primary adnexal tumors, and 15 cutaneous metastatic adenocarcinomas.
  • We found that variable D2-40 reactivity was seen in all of the primary cutaneous carcinomas including sebaceous carcinomas (10/10), squamous cell carcinomas (10/10), porocarcinomas (4/4), trichilemmal carcinomas (4/4), skin adnexal carcinomas not otherwise specified (4/4), and in the majority of benign skin adnexal tumors.
  • To confirm the initial findings and to further explore the utility of podoplanin reactivity in the distinction of these tumors, we also examined a test set of 35 unknown cases, including 21 adenocarcinomas metastatic to skin and 14 primary adnexal tumors, in a blinded fashion.
  • Of the 13 D2-40 positive cases, 12 were proven to be primary adnexal tumors.
  • Our results suggest that podoplanin can be a useful tool to distinguish primary skin adnexal carcinomas form adenocarcinomas metastatic to skin with high sensitivity (94.5%) and specificity (97.2%).
  • [MeSH-major] Adenocarcinoma / secondary. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / pathology. Membrane Glycoproteins / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / secondary

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  • (PMID = 17255777.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
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59. Gorva AD, Mohil R, Srinivasan MS: Aggressive digital papillary adenocarcinoma presenting as a paronychia of the finger. J Hand Surg Br; 2005 Oct;30(5):534

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aggressive digital papillary adenocarcinoma is a rare skin adnexal tumour, which has a predilection for the digits.
  • We report a case of this tumour presenting as a simple nail bed infection.

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  • (PMID = 16055244.001).
  • [ISSN] 0266-7681
  • [Journal-full-title] Journal of hand surgery (Edinburgh, Scotland)
  • [ISO-abbreviation] J Hand Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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60. Otomo T, Fuse N, Ishizawa K, Seimiya M, Shimura M, Ichinohasama R: Japanese case of follicular lymphoma of ocular adnexa diagnosed by clinicopathologic, immunohistochemical, and molecular genetic techniques. Clin Ophthalmol; 2010;4:1397-402

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  • [Title] Japanese case of follicular lymphoma of ocular adnexa diagnosed by clinicopathologic, immunohistochemical, and molecular genetic techniques.
  • BACKGROUND: Follicular lymphomas of the ocular adnexa are very rare in Japan, with only two reported cases.
  • CASE: A 44-year-old woman visited our clinic for treatment of ocular adnexal tumors in both eyes.

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  • (PMID = 21179225.001).
  • [ISSN] 1177-5483
  • [Journal-full-title] Clinical ophthalmology (Auckland, N.Z.)
  • [ISO-abbreviation] Clin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2999555
  • [Keywords] NOTNLM ; Japanese / READ system / fluorescence in situ hybridization / follicular lymphoma / ocular adnexa
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61. Nogales FF, Stolnicu S, Harilal KR, Mooney E, García-Galvis OF: Retiform uterine tumours resembling ovarian sex cord tumours. A comparative immunohistochemical study with retiform structures of the female genital tract. Histopathology; 2009 Mar;54(4):471-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • [Title] Retiform uterine tumours resembling ovarian sex cord tumours. A comparative immunohistochemical study with retiform structures of the female genital tract.
  • AIMS: To analyse both the clinicopathological and immunohistochemical findings in six cases of uterine tumours resembling ovarian sex cord tumours with a predominant epithelial retiform component resembling the rete ovarii (RUTROSCT) and to compare their immunophenotype with tissues containing retiform structures such as the normal rete ovarii, retiform Wolffian adnexal tumour (RWAT) and ovarian retiform areas of Sertoli-Leydig cell tumours (ORSLCT).
  • The average age of patients was 65 years, and all tumours behaved in a benign fashion.
  • Histologically they had a tubulopapillary or glomeruloid formation; a sex-cord-like or endometrial stromal component was absent or comprised at most 30% of the tumour.
  • CONCLUSIONS: RUTROSCTs have benign behaviour but may be confused with various uterine adenocarcinomas or metastases.
  • [MeSH-major] Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / metabolism. Sex Cord-Gonadal Stromal Tumors / pathology. Uterine Neoplasms / metabolism. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD56 / metabolism. Biomarkers, Tumor / metabolism. Calbindin 2. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Inhibins / metabolism. Keratin-7 / metabolism. Middle Aged. Mucin-1 / metabolism. Neprilysin / metabolism. S100 Calcium Binding Protein G / metabolism. Sertoli-Leydig Cell Tumor / metabolism. Sertoli-Leydig Cell Tumor / pathology

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  • [CommentIn] Histopathology. 2009 Nov;55(5):619-20; author reply 620-1 [19912370.001]
  • (PMID = 19309399.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Keratin-7; 0 / Mucin-1; 0 / S100 Calcium Binding Protein G; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 3.4.24.11 / Neprilysin
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62. Târcoveanu E, Dimofte G, Niculescu D, Vasilescu A, Moldovanu R, Ferariu D, Marcovici I: Ovarian fibroma in the era of laparoscopic surgery: a general surgeon's experience. Acta Chir Belg; 2007 Nov-Dec;107(6):664-9
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  • The ovarian fibroma is a rare benign tumor originating from the connective tissue of the ovarian cortex.
  • Only four cases required emergency operations due to either tumors or adnexal torsion.
  • Surgical treatment consisted of five ovarectomies, three adnexal resections and five total hysterectomies with bilateral salpingo-oophorectomy.

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  • (PMID = 18274181.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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63. De Francesco V, Frattasio A, Pillon B, Stinco G, Scott CA, Trotter D, Patrone P: Carcinosarcoma arising in a patient with multiple cylindromas. Am J Dermatopathol; 2005 Feb;27(1):21-6
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  • Familial cylindromatosis (Brooke-Spiegler syndrome) is a rare autosomal dominant inherited disease characterized by the development of adnexal tumors, mostly cylindromas, but also trichoepitheliomas and spiradenomas.
  • Malignant tumors may occur, usually with the features of a cylindrocarcinoma.
  • In 1997 she underwent surgical excision of the entire forehead and scalp with skin grafting.
  • The lesion was excised and histologic and immunohistochemical evaluation revealed a malignant cutaneous biphasic tumor extending into the subcutis, consisting of a major portion with the features of an adnexal carcinoma and of a minor one of atypical spindle cells.
  • Biphasic malignant skin tumors are rare and only a limited number have been described, none in association with the Brooke-Spiegler syndrome.
  • The authors discuss the morphogenesis of the folliculosebaceous-apocrine unit from which the tumors in this syndrome derive, and the pivotal role of mesenchymal cells in determining the process.
  • Since the Brooke-Spiegler syndrome is characterized by a germline mutation in the CYLD oncosuppressor gene, a biphasic tumor in this setting may represent a true carcinosarcoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Skin Appendage / pathology. Carcinosarcoma / pathology. Neoplasms, Second Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Skin Transplantation. Treatment Outcome

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  • (PMID = 15677972.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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64. Gupta R, Singh S, Gupta K, Kudesia M: Clear-cell hidradenoma in a child: a diagnostic dilemma for the cytopathologist. Diagn Cytopathol; 2009 Jul;37(7):531-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary cutaneous tumors are infrequently subjected to fine needle aspiration cytology.
  • As a result, the cytological reports of skin adnexal tumors like hidradenoma are scarce in the available literature.
  • The cytological features, in conjunction with the clinical examination, suggested a skin appendageal tumor.
  • Though nuclear pleomorphism and occasional larger nucleus posed a cytological diagnostic challenge, a diagnosis of benign appendageal tumor was suggested, considering the young age of the patient.
  • The cytopathologist should consider skin appendageal tumors during evaluation of cutaneous nodules.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Skin Neoplasms / pathology

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19459171.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Van Holsbeke C, Van Calster B, Testa AC, Domali E, Lu C, Van Huffel S, Valentin L, Timmerman D: Prospective internal validation of mathematical models to predict malignancy in adnexal masses: results from the international ovarian tumor analysis study. Clin Cancer Res; 2009 Jan 15;15(2):684-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prospective internal validation of mathematical models to predict malignancy in adnexal masses: results from the international ovarian tumor analysis study.
  • PURPOSE: To prospectively test the mathematical models for calculation of the risk of malignancy in adnexal masses that were developed on the International Ovarian Tumor Analysis (IOTA) phase 1 data set on a new data set and to compare their performance with that of pattern recognition, our standard method.
  • CONCLUSION: This internal validation of mathematical models to estimate the malignancy risk in adnexal tumors shows that the IOTA models had a diagnostic performance similar to that in the original data set.
  • [MeSH-major] Adnexal Diseases / diagnosis. Adnexal Diseases / pathology. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology

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  • (PMID = 19147775.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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66. Goh SG, Carr R, Dayrit JF, Calonje E: Mucinous hidradenoma: a report of three cases. J Cutan Pathol; 2007 Jun;34(6):497-502

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mucinous cutaneous adnexal tumors are an uncommon occurrence.
  • The tumor was also interpretated as a mucinous hidradenoma, most likely of follicular-apocrine origin.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Cystadenoma, Mucinous / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17518780.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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67. Zaballos P, Llambrich A, Ara M, Olazarán Z, Malvehy J, Puig S: Dermoscopic findings of haemosiderotic and aneurysmal dermatofibroma: report of six patients. Br J Dermatol; 2006 Feb;154(2):244-50
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  • However, the differentiation of dermatofibroma from other cutaneous tumours is difficult in some instances, primarily in atypical cases and rare variants.
  • The clinical differential diagnosis of haemosiderotic or aneurysmal dermatofibroma must include melanoma and other melanocytic tumours, vascular neoplasms, adnexal tumours and nonspecific cysts.
  • Dermoscopy improves the diagnostic accuracy in pigmented and nonpigmented skin lesions.
  • [MeSH-major] Dermoscopy. Hemosiderin / analysis. Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentIn] Br J Dermatol. 2007 Jan;156(1):199-200 [17199605.001]
  • (PMID = 16433792.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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68. Bhadani PP, Sen R, Bhadani UK, Karki S, Agarwal S: Is fine needle aspiration cytology (FNAC) useful in skin adnexal masses? A study on 5 cases of pilomatixoma. Indian J Pathol Microbiol; 2007 Apr;50(2):411-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is fine needle aspiration cytology (FNAC) useful in skin adnexal masses? A study on 5 cases of pilomatixoma.
  • Superficial cutaneous/subcutaneous nodules, caused by a variety of inflammatory, benign and malignant pathology of diverse origin, are tempting lesion for fine needle aspiration cytology (FNAC).
  • Amongst these, adnexal tumor show considerable overlap, both in clinical manifestation as well as in histopathology.
  • Other cases were diagnosed as epidermal inclusion cyst with the differential diagnosis of well differentiated squamous cell carcinoma and skin appendageal tumor of undetermined origin in one case each.
  • [MeSH-major] Hair Diseases / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 17883095.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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69. Silva CS, Souza MB, Lima KA, de Almeida MA, Criado PR: [Generalized eruptive syringoma: case report]. Dermatol Online J; 2009;15(2):7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Siringoma eruptivo disseminado: Relato de caso.
  • Syringomas are benign adnexal tumors derived from the intraepidermal portion of eccrine sweat ducts.
  • Clinically, they usually appear as small yellow or skin-colored papules ranging from 1-3 mm in diameter on the lower eyelids.
  • [MeSH-major] Skin / pathology. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19336024.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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70. Mahlberg MJ, McGinnis KS, Draft KS, Fakharzadeh SS: Multiple eccrine poromas in the setting of total body irradiation and immunosuppression. J Am Acad Dermatol; 2006 Aug;55(2 Suppl):S46-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eccrine poromas are benign, adnexal tumors that most often occur as a solitary lesion on the palm or sole.
  • Before the appearance of these tumors, the patient had received total body irradiation and allogeneic bone marrow transplantation for treatment of acute lymphocytic leukemia.

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  • (PMID = 16843124.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
  • [Number-of-references] 21
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71. Samaila MO: Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med; 2008 Mar;7(1):6-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adnexal skin tumors in Zaria, Nigeria.
  • BACKGROUND: Adnexal skin tumors share many features in common and differentiate along one line.
  • They may be clinically confused with other cutaneous tumors.
  • The aim of this report is to review and classify all adnexal tumors seen in a pathology department over a 16-year period.
  • METHOD: A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006.
  • RESULTS: Fifty-two adnexal tumors were seen, accounting for 0.9% of all cutaneous tumors seen within the same period.
  • Only two cases had a clinical diagnosis of adnexal tumor.
  • Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas.
  • Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma.
  • Tumours of hair follicle were 4 (7.7%) and included trichoepithelioma, characterized microscopically by multiple horn cysts and epithelial tracts connecting abortive pilar structures and a trichofolliculoma.
  • Forty-six lesions (88.5%) were benign and six (11.5%) malignant.
  • CONCLUSION: Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors.
  • Malignant adnexal tumors are uncommon in our setting.
  • [MeSH-major] Carcinoma, Skin Appendage / classification. Neoplasms, Adnexal and Skin Appendage / classification
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / pathology. Adenoma, Sweat Gland / epidemiology. Adenoma, Sweat Gland / pathology. Adolescent. Adult. Aged. Child. Child, Preschool. Female. Hair Follicle / pathology. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / pathology. Humans. Infant, Newborn. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / pathology. Sweat Gland Neoplasms / epidemiology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18702242.001).
  • [ISSN] 1596-3519
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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72. Mataix J, Bañuls J, Botella R, Laredo C, Lucas A: [Brooke-Spiegler syndrome: an heterogeneous entity]. Actas Dermosifiliogr; 2006 Dec;97(10):669-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Síndrome de Brooke-Spiegler: una entidad heterogénea.
  • The Brooke-Spiegler syndrome is a rare, autosomally dominant disease with a predisposition to develop different adnexal tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Neoplasms, Basal Cell / genetics. Neoplasms, Multiple Primary / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 17173833.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 30
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73. Tokyol C, Aktepe F, Yavas BD, Yildiz H, Aycicek A: Chondroid syringoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):973-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Chondroid syringoma is a benign skin adnexal tumor.
  • The reported incidence of chondroid syringoma among primary skin tumors is low and has been reported at 0.01-0.098%.
  • A diagnosis of benign appendageal tumor of the skin was made.
  • Surgical excision of tumor was done.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lip Neoplasms / pathology

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  • (PMID = 21053580.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Hong SK, Lee HJ, Cho SH, Seo JK, Lee D, Sung HS: Syringomas Treated by Intralesional Insulated Needles without Epidermal Damage. Ann Dermatol; 2010 Aug;22(3):367-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Syringoma is a benign adnexal tumor derived from intradermal eccrine ducts; it predominantly occurs in women at puberty or later in life.
  • Although syringoma is a common benign neoplasm, there have been no effective therapies for its removal.

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  • [Cites] Dermatol Surg. 2007 Mar;33(3):310-3 [17338688.001]
  • [Cites] J Clin Pathol. 2007 Feb;60(2):145-59 [16882695.001]
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  • (PMID = 20711282.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2917699
  • [Keywords] NOTNLM ; Insulated needle / Syringoma
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75. Lesin J, Forko-Ilić J, Plavec A, Planinić P: Management of Wolffian duct tumor recurrence without chemotherapy. Arch Gynecol Obstet; 2009 Nov;280(5):855-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of Wolffian duct tumor recurrence without chemotherapy.
  • BACKGROUND: A female adnexal tumor of probable Wolffian origin (FATWO) is a rare neoplasm which is considered to have a low malignant potential.
  • CASE: In 2006, a 60-year-old patient was admitted to hospital with solid tumor on the vaginal cuff confirmed by abdominal/pelvic CT, 6 years after her first FATWO was diagnosed and hysterectomy, bilateral adnexectomy, and omentectomia were done.
  • Pelvic washings, lysis of adhesions, and excision of tumor mass were performed.
  • Pathologic examination revealed malignant epithelial neoplasm of Wolffian origin with morphologic features similar to those of the patient's prior tumor.

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  • (PMID = 19288122.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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76. Knoedler D, Susnik B, Gonyo MB, Osipov V: Giant apocrine hidradenoma of the breast. Breast J; 2007 Jan-Feb;13(1):91-3
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  • We report a case of a 26-year-old woman with an 8.0-cm tumor of the left breast.
  • The tumor was clinically and radiologically suspicious for malignancy.
  • The pathologic evaluation of the core biopsy and the subsequent excision specimen revealed a benign sclerosing, cystic, and papillary adnexal tumor with apocrine and clear cell morphology.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Breast Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17214802.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Kamiya H, Kitajima Y, Ban M: Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells. J Dermatol; 2006 Dec;33(12):858-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells.
  • Bowen's disease rarely exhibits multiple combinations of premalignant and/or malignant skin lesions.
  • Bowen's disease with invasive adnexal carcinoma was originally described by Kao, but is not well recognized by clinicians due to its rarity and lack of specific clinical features of this condition.
  • Herein, we describe three unusual cases of Bowen's disease with invasive adnexal carcinoma.
  • In cases 1 and 3, we confirmed the adnexal tumor within tumors of Bowen's disease, the diagnosis of which is eccrine porocarcinoma.
  • The tumor in case 2 was characteristic to trichilemmal carcinoma.
  • Immunohistochemically, the tumor cells of Bowen's disease and the adnexal carcinoma differed in antigenicities.
  • [MeSH-major] Bowen's Disease / pathology. Carcinoma, Skin Appendage / pathology. Cell Transformation, Neoplastic / pathology. Skin Neoplasms / pathology

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  • (PMID = 17169090.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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78. Bhosale P, Iyer R: Diagnostic imaging in gynecologic malignancy. Minerva Ginecol; 2008 Apr;60(2):143-54
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  • This article summarizes the diagnostic performance (sensitivity, specificity, positive and negative likelihood ratios) of US, CT, MRI and PET/CT in the diagnosis of various gynecological diseases and tumors.
  • US is the first-line imaging modality of choice and is used to discriminate between benign and malignant adnexal masses and for characterizing adnexal tumors such as dermoid cyst, endometrioma, hemorrhagic corpus luteum, etc., for diagnosing intrauterine pathology in women with dysfunctional uterine bleeding, and for confirming or refuting pelvic pathology in women with pelvic pain.
  • MRI can play a role in detecting the extent of disease and helps in local staging of gynecologic tumors.


79. Sariya D, Ruth K, Adams-McDonnell R, Cusack C, Xu X, Elenitsas R, Seykora J, Pasha T, Zhang P, Baldassano M, Lessin SR, Wu H: Clinicopathologic correlation of cutaneous metastases: experience from a cancer center. Arch Dermatol; 2007 May;143(5):613-20
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  • OBJECTIVE: To analyze the clinical, histopathologic, and immunohistochemical characteristics of skin metastases.
  • PATIENTS: Fifty-one patients (21 men and 30 women) with biopsy-proven skin metastases and correlative clinical data.
  • INTERVENTIONS: Four dermatopathologists reviewed a random mixture of metastases and primary skin tumors.
  • Immunohistochemical studies for 12 markers were performed on the metastases, with skin adnexal tumors as controls.
  • RESULTS: Eighty-six percent (43 of 50) of the patients had known stage IV cancer, and skin metastasis was the presenting sign in 12% (6 of 50).
  • Metastases from small cell carcinomas and sarcomas were histologically misinterpreted as primary skin tumors.
  • Immunohistochemical analysis using a panel including p63, B72.3, calretinin, and CK5/6 differentiated metastatic carcinoma from primary skin adnexal tumors.
  • CONCLUSIONS: Cutaneous metastases can have variable clinical appearances and can mimic benign skin lesions.
  • [MeSH-major] Skin Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cancer Care Facilities. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 17515511.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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80. Adamicová K, Fetisovová Z, Mellová Y, Výbohová D: [Diagnostic procedures in skin adnexal tumours]. Cesk Patol; 2006 Apr;42(2):59-65

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic procedures in skin adnexal tumours].
  • From histogenetic, morphologic and immunohistochemical point of view the authors try to make possible algorithms that can be employed in a routine diagnosis of adnexal skin tumours.
  • They stress the importance of knowledge of clinical data necessary for orientation classification of tumour skin lesions after biopsies.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / diagnosis

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  • (PMID = 16715628.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 33
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81. Dubb M, Michelow P: Cytologic features of hidradenoma in fine needle aspiration biopsies. Acta Cytol; 2009 Mar-Apr;53(2):179-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To review the cytologic features of hidradenoma to describe criteria that may aid in identification of these tumors at the time of aspiration and allow for a more specific diagnosis than the umbrella term of benign skin adnexal tumor.
  • Fine needle aspiration (FNA) of these lesions showed the presence of benign skin adnexal tumors.
  • CONCLUSION: Knowledge of the cytologic features of hidradenoma will allow for correct management of the patient and prevent misdiagnosis as a malignant tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19365971.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Kishida ES, Muniz Silva MA, da Costa Pereira F, Sanches JA Jr, Sotto MN: Epidermal nevus syndrome associated with adnexal tumors, spitz nevus, and hypophosphatemic vitamin D-resistant rickets. Pediatr Dermatol; 2005 Jan-Feb;22(1):48-54
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  • [Title] Epidermal nevus syndrome associated with adnexal tumors, spitz nevus, and hypophosphatemic vitamin D-resistant rickets.
  • We present a patient with epidermal nevus syndrome associated with hypophosphatemic vitamin D-resistant rickets and multiple adnexal and spindle cell tumors.
  • [MeSH-major] Hypophosphatemia, Familial / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Child. Female. Humans. Hypophosphatemia / metabolism. Nevus. Nevus, Pigmented. Skin. Syndrome


83. Jariwala A, Evans A, McLeod G: Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. Foot Ankle Surg; 2010 Jun;16(2):e32-3
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  • Malignant eccrine spiradenoma (MES) is a rare adnexal tumour derived from cutaneous sweat glands.
  • We wish to emphasise through this case report the importance of keeping this rare but potentially lethal tumour in mind when managing chronic non-healing ulcers in extremities.

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  • [Copyright] Copyright 2009 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20483125.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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84. Dubb M, Michelow P, Grayson W: Cytologic features of trichoblastoma in fine needle aspiration biopsies. Acta Cytol; 2009 Nov-Dec;53(6):679-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To review the cytologic features of trichoblastoma in order to define criteria that may aid in identification of these tumors at the time of aspiration and allow a definitive diagnosis.
  • On fine needle aspiration, the patient was diagnosed as having a benign skin adnexal tumor.
  • RESULTS: The cytologic features of trichoblastoma resembled a cellular fibroadenoma/phyllodes tumor on aspiration, not previously described in the literature.
  • If the cytomorphology of a skin or subcutaneous aspirate appears to resemble that of a fibroadenoma, the diagnosis of a trichoblastoma should be entertained.
  • If the tumor occurs in the region of the breast, distinction from a fibroadenoma would be difficult if these additional features were not prominent.
  • CONCLUSION: Knowledge of the cytologic features of trichoblastoma will allow correct management of the patient and prevent misdiagnosis as other benign or malignant tumors.

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  • (PMID = 20014558.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Yazbek J, Ameye L, Timmerman D, Testa AC, Valentin L, Holland TK, Van Holsbeke C, Jurkovic D: Use of ultrasound pattern recognition by expert operators to identify borderline ovarian tumors: a study of diagnostic performance and interobserver agreement. Ultrasound Obstet Gynecol; 2010 Jan;35(1):84-8
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  • [Title] Use of ultrasound pattern recognition by expert operators to identify borderline ovarian tumors: a study of diagnostic performance and interobserver agreement.
  • OBJECTIVE: To assess the accuracy and reproducibility of ultrasound 'pattern recognition' for the diagnosis of borderline ovarian tumors by asking experienced ultrasound operators to evaluate representative images of different types of adnexal tumor.
  • METHODS: Digitally stored static two-dimensional B-mode images of representative cases of benign, borderline and invasive malignant ovarian tumors were independently assessed by three expert sonologists who had not performed the original real-time ultrasound examination.
  • The outcome measures included diagnostic accuracy and interobserver agreement in the diagnosis of benign, borderline or invasive malignant ovarian tumors.
  • A correct classification was made by all three experts in 83% of the primary invasive cancers, 76% of the benign masses and in 44% of the borderline malignant tumors (P < 0.01).
  • The experts showed a tendency to misclassify borderline tumors as benign rather than primary invasive (ratio of 8 : 1 for Expert A, 4 : 1 for B and 6 : 1 for C).
  • The interobserver agreement between any two experts was very good when they were tested for their ability to discriminate between invasive and non-invasive (benign and borderline) ovarian tumors (Cohen's kappa 0.85-0.88), but poorer for the discrimination between malignant (invasive and borderline) and benign tumors (kappa 0.70-0.78).
  • CONCLUSIONS: The accuracy of ultrasound diagnosis of borderline tumors is lower in comparison with benign and invasive malignant lesions.
  • The diagnostic performance and interobserver agreement are better when the outcomes are dichotomized into non-invasive and invasive malignant lesions, as opposed to the traditional diagnosis of benign and malignant tumors.
  • [MeSH-major] Adnexal Diseases / ultrasonography. Ovarian Neoplasms / ultrasonography. Pattern Recognition, Visual

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  • (PMID = 19746450.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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86. Thapliyal N, Joshi U, Vaibhav G, Sayana A, Srivastava AK, Jha RS: Pilomatricoma mimicking small round cell tumor on fine needle aspiration cytology: a case report. Acta Cytol; 2008 Sep-Oct;52(5):627-30
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  • [Title] Pilomatricoma mimicking small round cell tumor on fine needle aspiration cytology: a case report.
  • BACKGROUND: Pilomatricoma, a benign skin adnexal tumor, frequently leads to false positive diagnosis cytologically.
  • We report a rapidly growing nodular swelling misdiagnosed as round cell tumor cytologically and found to be pilomatricoma histopathologically.
  • CASE: A 32-year-old man presented with a rapidly growing, mobile nodule on his left arm for 4 months with fixed, shiny overlying skin.
  • Cytologically the diagnosis of blue round cell tumor was made.
  • To avoid misdiagnosis, all skin-based nodules should undergo extensive cytologic sampling from diferent sites.
  • [MeSH-major] Carcinoma, Merkel Cell / diagnosis. Carcinoma, Small Cell / diagnosis. Hair Diseases / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Collagen Type II / metabolism. DNA-Binding Proteins / metabolism. Diagnosis, Differential. Diagnostic Errors. Humans. Keratin-3 / metabolism. Male

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  • (PMID = 18833830.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type II; 0 / DNA-Binding Proteins; 0 / KRT3 protein, human; 0 / Keratin-3; 0 / TTF1 protein, human
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87. Timmerman D, Testa AC, Bourne T, Ferrazzi E, Ameye L, Konstantinovic ML, Van Calster B, Collins WP, Vergote I, Van Huffel S, Valentin L, International Ovarian Tumor Analysis Group: Logistic regression model to distinguish between the benign and malignant adnexal mass before surgery: a multicenter study by the International Ovarian Tumor Analysis Group. J Clin Oncol; 2005 Dec 1;23(34):8794-801
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  • [Title] Logistic regression model to distinguish between the benign and malignant adnexal mass before surgery: a multicenter study by the International Ovarian Tumor Analysis Group.
  • PURPOSE: To collect data for the development of a more universally useful logistic regression model to distinguish between a malignant and benign adnexal tumor before surgery.
  • The outcome measure was the histologic classification of excised tissues as malignant or benign.
  • RESULTS: Data from 1,066 patients recruited from nine European centers were included in the analysis; 800 patients (75%) had benign tumors and 266 (25%) had malignant tumors.
  • (1) personal history of ovarian cancer, (2) hormonal therapy, (3) age, (4) maximum diameter of lesion, (5) pain, (6) ascites, (7) blood flow within a solid papillary projection, (8) presence of an entirely solid tumor, (9) maximal diameter of solid component, (10) irregular internal cyst walls, (11) acoustic shadows, and (12) a color score of intratumoral blood flow.
  • [MeSH-major] Adnexal Diseases / diagnosis. Preoperative Care / statistics & numerical data
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / blood. CA-125 Antigen / blood. Cystadenoma, Mucinous / classification. Cystadenoma, Mucinous / diagnosis. Cystadenoma, Mucinous / surgery. Cystadenoma, Papillary / classification. Cystadenoma, Papillary / diagnosis. Cystadenoma, Papillary / surgery. Cystadenoma, Serous / classification. Cystadenoma, Serous / diagnosis. Cystadenoma, Serous / surgery. Diagnosis, Differential. Female. Humans. Logistic Models. Middle Aged. Multivariate Analysis. Ovarian Cysts / classification. Ovarian Cysts / diagnosis. Ovarian Cysts / surgery. Ovarian Neoplasms / classification. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / surgery. Ovariectomy. Prospective Studies. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 16314639.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen
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88. Dubb M, Michelow P: Cytologic features of chondroid syringoma in fine needle aspiration biopsies: a report of 3 cases. Acta Cytol; 2010 Mar-Apr;54(2):183-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, most clinicians prefer to diagnose suspected skin tumors by excisional biopsy as they are easily accessible, with the result that benign skin adnexal tumors are rarely encountered on FNA, often leading to misdiagnosis and mismanagement of patients.
  • Case 2 was an 18-year-old female who presented with a 0.5-cm mass involving the skin of the upper lip.
  • All the masses involved the skin/subcutaneous tissue on clinical examination.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Biopsy, Fine-Needle. Epithelial Cells / pathology. Female. Humans. Male. Scalp. Skin / pathology. Young Adult

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  • (PMID = 20391975.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Schadt CR, Boyd AS: Eccrine syringofibroadenoma with co-existent squamous cell carcinoma. J Cutan Pathol; 2007 Dec;34 Suppl 1:71-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal tumor arising most often on the extremities of elderly individuals.
  • Histologically, the tumor consists of anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Squamous Cell / pathology. Eccrine Glands / pathology. Fibroadenoma / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17997744.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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90. Huchon C, Bats AS, Bensaïd C, Junger M, Nos C, Chatellier G, Lécuru F: [Adnexal masses management: a prospective multicentric observational study]. Gynecol Obstet Fertil; 2008 Nov;36(11):1084-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adnexal masses management: a prospective multicentric observational study].
  • [Transliterated title] Prise en charge des masses annexielles organiques : résultats d'une enquête de pratique.
  • OBJECTIVES: The aim of this study was first to describe the adnexal masses diagnoses and their management and secondly to assess the oncological relevance of these strategies.
  • PATIENTS AND METHODS: A prospective multicentric observational study of organic adnexal masses was conducted between June and November 2005.
  • All patients presenting an organic adnexal tumor and for which a definitive histological diagnosis was subsequently available were eligible.
  • RESULTS: Among the 278 patients treated for an adnexal mass during the study-period, 166 were included.
  • In all, 83.1% of tumors were found benign, 12.7% were malignant and 4.2% were borderlines on definitive histological examination.
  • Among those treated by cystectomy, one borderline tumor was found, whereas in those treated by adnexectomy, five borderline and 12 malignant masses were discovered.
  • Peroperative conversion rates were 16% and 50% in borderline and malignant tumors.
  • A minimal preoperative assessment was defined, based upon the dimensions of the tumor and the dosage of at least one marker.
  • DISCUSSION AND CONCLUSION: Ovarian borderline tumors and carcinomas are an important contingent of this study (16.9%).
  • The management observed in this study is adapted to benign lesions.
  • [MeSH-major] Adnexal Diseases / surgery

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  • [CommentIn] Gynecol Obstet Fertil. 2009 Jan;37(1):1-2 [19084459.001]
  • (PMID = 18964176.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Multicenter Study
  • [Publication-country] France
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / Carcinoembryonic Antigen
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91. Iura A, Sasajima Y, Katsumata N, Kasamatsu T: Serous adenocarcinoma of the retroperitoneum, as a type of multifocal müllerian carcinoma. Int J Clin Oncol; 2009 Jun;14(3):254-7
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  • On MRI, the tumor was 17 x 10 x 6 cm in size and monocystic.
  • The tumor cells were positive for CA125, estrogen receptor, and Wilms tumor 1, and were differentiated from enterogenic cyst by the presence of cytokeratin 7 (+), and the absence of cytokeratin 20 (-).
  • Simultaneously, uterine adnexal serous adenocarcinoma was detected.
  • The volume of the retroperitoneal tumor was 14 times larger than that of the uterine adnexal tumor.
  • We suggest the possibility that the retroperitoneal cancer arose as a primary cancer from rests of the müllerian epithelium synchronously with the uterine adnexal cancer.
  • The patient had been taking conjugated estrogen for 10 years, suggesting that long-term estrogen stimulation may have contributed to the progression of the tumors.
  • [MeSH-major] Adnexa Uteri / pathology. Cystadenocarcinoma, Serous / pathology. Mullerian Ducts / pathology. Peritoneal Neoplasms / pathology

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  • (PMID = 19593619.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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92. Gauerke S, Driscoll JJ: Hidradenocarcinomas: a brief review and future directions. Arch Pathol Lab Med; 2010 May;134(5):781-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hidradenocarcinomas are rare, aggressive skin adnexal tumors of sweat gland origin that demonstrate a high potential for local recurrence, metastasis, and poor outcome.
  • These neoplasms can derive from preexisting clear cell hidradenomas but more commonly appear de novo, with the molecular events responsible for the pathogenesis currently unknown.
  • Historically, diagnosis has been difficult because of the few cases, inconsistent nomenclature, variable morphology of cells that compose the neoplasm, and confusion with other visceral metastatic tumors.
  • Presentation is generally benign with an indolent clinical course that typically includes local and multiple recurrences.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Diagnosis, Differential. Humans. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 20441512.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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93. Gangane N, Joshi D, Sharma SM: Cytomorphological diagnosis of malignant eccrine tumors: report of two cases. Diagn Cytopathol; 2008 Nov;36(11):801-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphological diagnosis of malignant eccrine tumors: report of two cases.
  • Though FNAC has been successfully used in diagnosing various neoplastic and nonneoplastic cutaneous lesions, there is a paucity of case reports describing the cytomorphological features of adnexal tumors.
  • We hereby describe the cytological features of two histologically confirmed cases of malignant eccrine tumors.
  • A cytological diagnosis of low grade papillary adenocarcinoma arising from skin adnexal structures was given in case number 1.
  • Careful cytological examination displayed the characteristic of two cell population seen in eccrine tumors in both the cases.
  • Diagnosis of malignant eccrine tumors cannot be made with certainity on cytology alone, hence the need to document the cytological features of these entities is emphasized.

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  • (PMID = 18831018.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Yi WS, Xu XL, Xiang Q, Jiang HB: [Characteristics of ocular adnexal non-Hodgkin lymphoma]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 Sep;33(9):826-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Characteristics of ocular adnexal non-Hodgkin lymphoma].
  • OBJECTIVE: To investigate the clinical manifestation and pathological features of primary ocular adnexal non-Hodgkin lymphoma.
  • METHODS: Data of 18 patients with biopsy-proven ocular adnexal non-Hodgkin lymphoma at Xiangya hospital were reviewed.The disease site, clinical manifestation,imaging and pathological features of the tumor were summarized.
  • RESULTS: All patients had typical presentation of an adnexal mass.Twelve(66.7%) patients had orbital involvement, 3(16.7%) had conjunctival, and 3(16.7%) had lymphoma involving the eyelids.Eight patients were misdiagnosed as "inflammatory pseudotumour" before the operation according to their clinical and imaging examination,another 8 patients were diagnosed as "ocular adnexal tumour with unknown nature" before the operation.
  • CONCLUSION: The typical presentation of ocular adnexal lymphoma is a painless mass.Orbital connective tissue is the most involved anatomical site.
  • The diagnosis of ocular adnexal non-Hodgkin lymphoma is difficult which could easily be misdiagnosed as "inflammatory pseudotumour".

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  • (PMID = 18812662.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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95. Bulliard C, Murali R, Maloof A, Adams S: Endocrine mucin-producing sweat gland carcinoma: report of a case and review of the literature. J Cutan Pathol; 2006 Dec;33(12):812-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mucinous carcinoma of skin (MCS) is an uncommon adnexal tumor of disputed differentiation.

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  • (PMID = 17177942.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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96. Plaza JA, Ortega PF, Bengana C, Stockman DL, Suster S: Immunolabeling pattern of podoplanin (d2-40) may distinguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases. Am J Dermatopathol; 2010 Oct;32(7):683-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • When the morphologic distinction between basal cell carcinomas (BCCs) and tichoepitheliomas is unclear, it poses a rare diagnostic challenge as the commonly defined histologic criterion is insufficient for differentiating these two neoplasms from each other.
  • Podoplanin (D2-40) is a well-known lymphatic endothelial surface marker that has been postulated to be upregulated in the outer root sheath of hair follicles and cutaneous neoplasms, such as adnexal tumors, squamous cell carcinomas, etc.
  • A total of 49 cutaneous tumors, including 22 cases of trichoepitheliomas and 27 cases of BCC were examined.
  • This data suggests that D2-40 expression could be a useful potential marker to distinguish BCCs from trichoepitheliomas, especially when there is a high index of histologic suspicion for either of these two tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Membrane Glycoproteins / biosynthesis. Neoplasms, Basal Cell / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20559122.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
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97. Mamelak AJ, Goldberg LH, Katz TM, Graves JJ, Arnon O, Kimyai-Asadi A: Desmoplastic trichoepithelioma. J Am Acad Dermatol; 2010 Jan;62(1):102-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Desmoplastic trichoepithelioma (DTE) is an uncommon adnexal tumor usually found on the face of young women.
  • OBJECTIVE: We sought to describe the clinical and histologic characteristics of DTE and discuss management strategies for these tumors.
  • Approximately 38% of the tumors had been present for 1 to 2 years before presentation.
  • The average size of the tumors at the time of surgery was 0.8 x 0.6 cm.
  • To date, none of the tumors have recurred.
  • CONCLUSION: DTE is a benign tumor that has a predilection for the face.
  • With its rapid growth, aggressive histologic features that may be confused with basal cell carcinoma, and tendency to arise in cosmetically and functionally sensitive areas, these tumors should be removed in a manner that assures clear surgical margins, such as Mohs micrographic surgery.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology
  • [MeSH-minor] Adult. Carcinoma, Basal Cell / pathology. Cheek. Female. Humans. Male. Middle Aged. Mohs Surgery. Retrospective Studies. Skin Neoplasms / pathology

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  • [CommentIn] J Am Acad Dermatol. 2011 Feb;64(2):438-9 [21238832.001]
  • (PMID = 20082889.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Balbi GC, Del Piano L, Labriola D, Visconti S, Monteverde A, Passaro M, Monaco R, Cardone A, Rossiello R, Panariello S, Montone L: Female adnexal tumor of probable wolffian origin: clinicopathological, immunohistochemical and cytofluorimetric analyses of a 22-year-old virgin. case report. Eur J Gynaecol Oncol; 2006;27(3):313-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Female adnexal tumor of probable wolffian origin: clinicopathological, immunohistochemical and cytofluorimetric analyses of a 22-year-old virgin. case report.
  • The term female adnexal tumor of probable Wolffian origin "FATWO" designs this tumor wich arises by the rare persisting remnants of the mesonephric duct (Wolffian duct).
  • At laparotomy the left adnexa were deformed by a well-capsulated mass, totally removed and sent to the pathologist with a specimen of peritoneal fluid and of the omentum.
  • [MeSH-major] Adnexal Diseases / pathology. Genital Neoplasms, Female / pathology. Wolffian Ducts

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  • (PMID = 16800270.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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99. Triaridis S, Papadopoulos S, Tsitlakidis D, Printza A, Grosshans E, Cribier B: Trichoblastic carcinoma of the pinna. A rare case. Hippokratia; 2007 Apr;11(2):89-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adnexal tumors of the hair follicle can be regarded as lesions that show similar differentiation to one or more portions of the hair follicle.
  • Trichoblastic carcinoma is a rare malignant adnexal tumor, which usually occurs on the scalp.

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  • [Cites] Acta Derm Venereol. 1998 May;78(3):173-6 [9602220.001]
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  • (PMID = 19582185.001).
  • [ISSN] 1790-8019
  • [Journal-full-title] Hippokratia
  • [ISO-abbreviation] Hippokratia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Other-IDs] NLM/ PMC2464267
  • [Keywords] NOTNLM ; malignant pilar tumor / pilar carcinoma / trichoblastic carcinoma
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100. Chetty R, Perez-Ordonez B, Gilbert R, Pagedar NA, Waldron J, Ghazarian D: Spiradenocarcinoma arising from a spiradenocylindroma: unusual case with lymphoepithelioma-like areas. J Cutan Med Surg; 2009 Jul-Aug;13(4):215-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Hybrid skin adnexal tumors are common, and spiradenocylindroma is well described.
  • OBJECTIVE: However, malignant transformation in this setting is infrequent, especially resemblance to lymphoepithelioma-like carcinoma of skin, which is not associated with Epstein-Barr virus.
  • METHODS: A 65-year-old female presented with ataxia and a skin nodule composed of a hybrid adnexal tumor (spiradenoma and cylindroma) that transitioned into an undifferentiated carcinoma with attendant lymphocytes and plasma cells.
  • The tumor was Epstein-Barr encoded RNAs (EBER) negative by in situ hybridization.
  • No evidence of neuroendocrine differentiation was seen in the tumor, despite the patient having symptoms of paraneoplastic ataxia that improved after surgery.
  • CONCLUSION: This case highlights the transition of a benign hybrid tumor (spiradenocylindroma) into a spiradenocarcinoma that resembled lymphoepithelioma-like carcinoma of skin.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 19706230.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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