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1. Nazarko L: 'Nurses must lead the discussion on HCA roles'. Nurs Times; 2008 Apr 8-14;104(14):10
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  • [Title] 'Nurses must lead the discussion on HCA roles'.

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  • (PMID = 18497231.001).
  • [ISSN] 0954-7762
  • [Journal-full-title] Nursing times
  • [ISO-abbreviation] Nurs Times
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Pereira FM, Bueno MI: Image evaluation with chemometric strategies for quality control of paints. Anal Chim Acta; 2007 Apr 11;588(2):184-91
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  • The images were converted in gray color scale histograms, the resulting data were organized into a matrix form and analyzed with the help of principal component analysis (PCA) and hierarchical cluster analysis (HCA).

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  • (PMID = 17386809.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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3. Zhao LH, Wu MH, Xiang BR: Analysis of Psoralea corylifolia L. fruits in different regions. Chem Pharm Bull (Tokyo); 2005 Aug;53(8):1054-7
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  • [Title] Analysis of Psoralea corylifolia L. fruits in different regions.
  • Application of multivariate data analysis has become a popular method in the last decades, mainly because it can provide information not otherwise accessible.
  • The information includes classification, searching similarities, finding relationships, finding physical significance to principal components, etc.
  • The results were studied by hierarchical cluster analysis (HCA) and principal components analysis (PCA).
  • [MeSH-minor] Chromatography, High Pressure Liquid. Cluster Analysis. Multivariate Analysis

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  • (PMID = 16079549.001).
  • [ISSN] 0009-2363
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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4. Popivanova BK, Li YY, Zheng H, Omura K, Fujii C, Tsuneyama K, Mukaida N: Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. Cancer Sci; 2007 Mar;98(3):321-8
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  • [Title] Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis.
  • We previously observed that Pim-3 with serine/threonine kinase activity, was aberrantly expressed in malignant lesions of endoderm-derived organs, liver and pancreas.
  • Moreover, Pim-3 proteins were detected in adenoma (35/40 cases) and normal mucosa (26/111 cases), which are adjacent to adenocarcinoma.
  • Pim-3 was constitutively expressed in SW480 cells and the transfection with Pim-3 short hairpin RNA promoted apoptosis.
  • In the same cell line, a pro-apoptotic molecule, Bad, was phosphorylated at Ser(112) and Ser(136) sites of phosphorylation that are representative of its inactive form.
  • Ser(112) but not Ser(136) phosphorylation in this cell line was abrogated by Pim-3 knockdown.
  • These observations suggest that Pim-3 can inactivate Bad by phosphorylating its Ser(112) in human colon cancer cells and thus may prevent apoptosis and promote progression of human colon cancer.
  • [MeSH-minor] Apoptosis / physiology. Cell Line, Tumor. Female. HCT116 Cells. HT29 Cells. Humans. Immunohistochemistry. Male

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  • (PMID = 17270021.001).
  • [ISSN] 1347-9032
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / bcl-Associated Death Protein; EC 2.7.11.1 / PIM3 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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5. House MG, Schulick RD: Endocrine tumors of the pancreas. Curr Opin Oncol; 2006 Jan;18(1):23-9
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  • PURPOSE OF REVIEW: Neoplasms of the endocrine pancreas, commonly referenced as pancreatic islet cell tumors, are rare, often well differentiated endocrine neoplasms, whose biology remains poorly characterized.
  • This article reviews the current clinical management of pancreatic islet cell tumors and describes the molecular events that have been studied to guide future therapies of these peculiar neoplasms.
  • RECENT FINDINGS: While some islet cell tumors arise in association with the MEN-1 syndrome, the majority of these neoplasms are sporadic lesions whose underlying genetic and molecular events remain largely unknown.
  • Recent work has identified changes in gene expression occurring in metastatic and non-metastatic islet cell tumors, which appear to correlate with the occurrence of lymph node and liver metastases.
  • In addition, multiple molecular alterations, including changes in expression of cellular proteins with migratory, cell cycle or angiogenic functions, have been demonstrated to influence islet cell tumor growth, invasion and metastatic spread.
  • SUMMARY: Understanding the molecular events underlying the biology of pancreatic islet cell tumors will aid the development of accurate prognostic markers and will guide improved therapeutic modalities in the future.
  • [MeSH-major] Adenoma, Islet Cell / therapy. Carcinoma, Islet Cell / therapy. Pancreatic Neoplasms / therapy

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  • [RetractionIn] Klastersky J. Curr Opin Oncol. 2006 Jul;18(4):414 [16721138.001]
  • (PMID = 16357560.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Retracted Publication; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / ELL protein, human; 0 / Transcriptional Elongation Factors
  • [Number-of-references] 51
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6. Herbst U, Fuchs JI, Teubner W, Steinberg P: Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Toxicol Appl Pharmacol; 2006 Apr 15;212(2):136-45
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  • [Title] Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
  • Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HCAs) ingested with food have repeatedly been suggested to be involved in the malignant transformation of colon epithelial cells.
  • In order to test this hypothesis, HCEC cells (SV40 large T antigen-immortalized human colon epithelial cells) were incubated with a racemic mixture of benzo[c]phenanthrene dihydrodiol epoxides (B[c]PhDE), extremely potent carcinogenic PAH metabolites in vivo, or with 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP), the N-hydroxylated metabolite of the most abundant HCA in cooked meat.
  • First, it was shown that HCEC cells express sulfotransferase 1A1, which is needed to metabolize N-OH-PhIP to the corresponding N-sulfonyloxy derivative, the direct precursor molecule of genotoxic nitrenium ions.
  • Thereafter, exponentially growing HCEC cells were exposed five times to 0.1 microg (0.37 nmol) B[c]PhDE/ml for 30 min or 0.72 microg (3 nmol) N-OH-PhIP/ml for 24 h.
  • Chemically treated HCEC cells showed an enhanced saturation density and grew faster than the corresponding solvent-treated cell cultures.
  • After five treatment cycles, HCEC(B[c]PhDE) as well as HCEC(N-OH-PhIP) cells lost cell-cell contact inhibition and started piling up and forming foci in the culture flasks.
  • Furthermore, HCEC(B[c]PhDE) and HCEC(N-OH-PhIP) cells were injected i.m. into SCID mice.
  • Within 6 weeks after injection, eight animals out of eight injected with HCEC(B[c]PhDE) or HCEC(N-OH-PhIP) cells developed tumors at the site of injection, thus demonstrating the high tumorigenic potential of the HCEC(B[c]PhDE) and HCEC(N-OH-PhIP) cell cultures.
  • Taken together, we show for the first time that the abovementioned active PAH metabolites as well as N-OH-PhIP are indeed able to malignantly transform human colon epithelial cells in vitro.
  • [MeSH-major] Carcinogens / toxicity. Cell Transformation, Neoplastic / drug effects. Colon / cytology. Epithelial Cells / physiology. Epoxy Compounds / toxicity. Imidazoles / toxicity. Phenanthrenes / toxicity. Pyridines / toxicity
  • [MeSH-minor] Animals. Blotting, Western. Cell Proliferation / drug effects. Dimethyl Sulfoxide / pharmacology. Humans. Immunohistochemistry. Mice. Mice, SCID

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  • (PMID = 16137733.001).
  • [ISSN] 0041-008X
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Epoxy Compounds; 0 / Imidazoles; 0 / Phenanthrenes; 0 / Pyridines; 124489-20-9 / 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; YOW8V9698H / Dimethyl Sulfoxide
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7. Koo JS, Seong JK, Park C, Yu DY, Oh BK, Oh SH, Park YN: Large liver cell dysplasia in hepatitis B virus x transgenic mouse liver and human chronic hepatitis B virus-infected liver. Intervirology; 2005;48(1):16-22
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  • [Title] Large liver cell dysplasia in hepatitis B virus x transgenic mouse liver and human chronic hepatitis B virus-infected liver.
  • OBJECTIVES: Large liver cell dysplasia (LCD) is frequently associated with hepatitis B virus (HBV), but it remains uncertain whether it is reactive, senescent or preneoplastic.
  • The immunohistochemical stain of proliferating cell nuclear antigen (PCNA), transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay and senescence-associated beta-galactosidase (SA-beta-Gal) were evaluated.
  • RESULTS: In HBX transgenic mice, LCD was developed since 3 months and formed small nodules of hepatocellular adenoma, which progressed to hepatocellular carcinoma.
  • [MeSH-major] Apoptosis. Hepatitis B, Chronic / pathology. Hepatocytes / pathology. Liver / pathology. Liver Cirrhosis / pathology. Trans-Activators / biosynthesis
  • [MeSH-minor] Adult. Animals. Cell Aging. Disease Models, Animal. Female. Humans. In Situ Nick-End Labeling. Male. Mice. Mice, Transgenic. Middle Aged. Proliferating Cell Nuclear Antigen / analysis


8. Catasus L, D'Angelo E, Pons C, Espinosa I, Prat J: Expression profiling of 22 genes involved in the PI3K-AKT pathway identifies two subgroups of high-grade endometrial carcinomas with different molecular alterations. Mod Pathol; 2010 May;23(5):694-702
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  • Expression profiling of 22 genes involved in PI3K-AKT signaling pathway was analyzed in 38 endometrial carcinomas using TaqMan low-density array (TLDA) analysis.
  • The gene expression pattern was analyzed by hierarchical clustering analysis.
  • Unsupervised clustering divided the high-grade endometrial carcinomas into two clusters.
  • Almost all non-endometrioid adenocarcinomas (serous and clear cell adenocarcinomas) were segregated into this cluster.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cluster Analysis. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Middle Aged. Signal Transduction / genetics. Tissue Array Analysis. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20173732.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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9. Delmo Walter EM, Hübler M, Alexi-Meskishvili V, Miera O, Weng Y, Loforte A, Berger F, Hetzer R: Staged surgical palliation in hypoplastic left heart syndrome and its variants. J Card Surg; 2009 Jul-Aug;24(4):383-91
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  • [Title] Staged surgical palliation in hypoplastic left heart syndrome and its variants.
  • BACKGROUND: Surgical options for infants with hypoplastic left heart syndrome (HLHS) and/or its variants are cardiac transplantation or the heart-preserving staged palliation with Norwood operation,followed by a two-staged Fontan procedure.
  • The causes of mortality were sepsis, capillary leak,or heart failure.
  • One patient underwent heart transplantation after the second stage because of heart failure.
  • Among 34 Norwood survivors, four are slightly tachypneic from a mild pulmonary hyperperfusion; one presents symptoms of minimal brain disease.
  • Lower operative weight, ascending aortic size, prolonged duration of cardiopulmonary bypass, and hypothermic circulatory arrest were identified to significantly influence early mortality after the Norwood procedure.
  • [MeSH-major] Cardiovascular Surgical Procedures / methods. Hypoplastic Left Heart Syndrome / mortality. Hypoplastic Left Heart Syndrome / surgery. Outcome Assessment (Health Care). Palliative Care
  • [MeSH-minor] Abnormalities, Multiple. Aorta / pathology. Arrhythmias, Cardiac / mortality. Body Weight. Cardiopulmonary Bypass / statistics & numerical data. Circulatory Arrest, Deep Hypothermia Induced. Female. Follow-Up Studies. Heart Failure / mortality. Humans. Infant. Infant, Newborn. Male. Multivariate Analysis. Retrospective Studies. Risk Factors. Sepsis / mortality. Time Factors

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  • (PMID = 19040407.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Venturi A, Piscaglia F, Vidili G, Flori S, Righini R, Golfieri R, Bolondi L: Diagnosis and management of hepatic focal nodular hyperplasia. J Ultrasound; 2007 Sep;10(3):116-27
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  • [Title] Diagnosis and management of hepatic focal nodular hyperplasia.
  • Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver, after hemangioma.
  • The main clinical task is to differentiate it from other hypervascular hepatic lesions such as hepatic adenoma, hepatocellular carcinoma, or hypervascular metastases, but invasive diagnostic procedures can generally be avoided with the appropriate use of imaging techniques.
  • Magnetic resonance (MR) imaging is more sensitive and specific than conventional ultrasonography (US) or computed tomography (CT), but Doppler US and contrast-enhanced US (CEUS) can greatly improve the accuracy in the diagnosis of FNH.
  • Once a correct diagnosis has been made, in most cases there is no indication for surgery, and treatment includes conservative clinical follow-up in asymptomatic patients.

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  • (PMID = 23396642.001).
  • [ISSN] 1971-3495
  • [Journal-full-title] Journal of ultrasound
  • [ISO-abbreviation] J Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3478711
  • [Keywords] NOTNLM ; Contrast-enhanced ultrasonography / Diagnosis / Focal nodular hyperplasia / Management / Ultrasonology
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11. Wang D, Lagerstrom R, Sun C, Bishof L, Valotton P, Götte M: HCA-vision: Automated neurite outgrowth analysis. J Biomol Screen; 2010 Oct;15(9):1165-70
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  • [Title] HCA-vision: Automated neurite outgrowth analysis.
  • Automating the analysis of neurons in culture represents a key aspect of the search for neuroactive compounds.
  • A number of commercial neurite analysis software packages tend to measure some basic features such as total neurite length and number of branching points.
  • The authors have developed a suite of image analysis tools that will allow researchers to produce quality analyses at primary screening rates.
  • In mixed cell populations, neurons can be filtered and separated from other brain cell types so that neurite analysis can be performed only on neurons.
  • It supports batch processing with a built-in database to store the batch-processing results, a batch result viewer, and an ad hoc query builder for users to retrieve features of interest.
  • The suite of tools has been deployed into a software package called HCA-Vision.
  • The free version of the software package is available at http://www.hca-vision.com.

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  • (PMID = 20855562.001).
  • [ISSN] 1552-454X
  • [Journal-full-title] Journal of biomolecular screening
  • [ISO-abbreviation] J Biomol Screen
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor
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12. ACHE Gold Medal Award. A high-flying career. HCA's Bovender feted for his outside contributions. Mod Healthc; 2007 Jan 29;37(5):28
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  • [Title] ACHE Gold Medal Award. A high-flying career. HCA's Bovender feted for his outside contributions.

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  • (PMID = 17319005.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Bovender J
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13. Evans CT, Hershow RC, Chin A, Foulis PR, Burns SP, Weaver FM: Bloodstream infections and setting of onset in persons with spinal cord injury and disorder. Spinal Cord; 2009 Aug;47(8):610-5
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  • [Title] Bloodstream infections and setting of onset in persons with spinal cord injury and disorder.
  • OBJECTIVE: Health-care-associated (HCA) bloodstream infection (BSI) has been shown to be a distinct epidemiologic category in the general adult population, but few studies have examined specific patient populations.
  • The objective of this study was to assess characteristics associated with BSI that occurred in the hospital (hospital-acquired, HA BSI), from health-care contact outside the hospital (HCA BSI) or in the community (community-acquired, CA BSI) in veterans with spinal cord injury and disorder (SCI&D).
  • RESULTS: Four hundred and thirteen episodes of BSI occurred in 226 patients, with a rate of 7.2 BSI episodes per 100 admissions: 267 (64.7%) were HA BSI, 110 (26.6%) were HCA BSI and 36 (8.7%) were CA BSI.
  • Antibiotic resistance was more common in those with HA BSI (65.5%) compared with that in those with HCA (49.1%, P=0.001) and CA BSI (22.2%, P<0.0001).
  • Methicillin resistance in Staphylococcus aureus was highly prevalent; HA BSI (84.5%), HCA BSI (60.6%) and CA BSI (33.3%).
  • CONCLUSION: HCA BSI comprises one-quarter of all BSIs in hospitalized patients with SCI&D.
  • Although those with HCA and CA BSI share similarities, several differences in medical characteristics and causal microorganism are noted.
  • Treatment and management strategies for HCA and CA infections need to vary.

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  • (PMID = 19238165.001).
  • [ISSN] 1476-5624
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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14. Holst RM, Laurini R, Jacobsson B, Samuelsson E, Sävman K, Doverhag C, Wennerholm UB, Hagberg H: Expression of cytokines and chemokines in cervical and amniotic fluid: relationship to histological chorioamnionitis. J Matern Fetal Neonatal Med; 2007 Dec;20(12):885-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To correlate cervical and amniotic fluid cytokines and macrophage-related chemokines to the development of histological chorioamnionitis (HCA) in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PPROM).
  • STUDY DESIGN: Cervical and amniotic fluid interleukin (IL)-6, IL-8, IL-18, monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 from pregnant women (at <or=34 weeks of gestation) in PTL (N = 42) were analyzed and related to the subsequent occurrence of HCA or inflammatory signs in the placenta.
  • RESULTS: Intra-amniotic levels of IL-6, IL-8, IL-18, MCP-1, and MCP-3 were significantly higher in PTL cases with HCA compared to non-HCA controls, whereas no such relationship was obtained in the PPROM group.
  • Cervical IL-8 and IL-6 (but not IL-18, MCP-1, MCP-2, and MCP-3) in PTL patients was associated with HCA, and at a cut-off level of 10.0 ng/mL cervical IL-8 was a strong predictor of HCA in the PTL cases (sensitivity 100%, specificity 67%, positive predictive value 63%, negative predictive value 100%).
  • The cytokine and chemokine levels in the group with inflammatory signs were generally higher than in controls but lower compared to the concentrations in the HCA group.
  • CONCLUSIONS: The amniotic levels of IL-6, IL-8, IL-18, and the CC-chemokines MCP-1 and MCP-3 in PTL patients all predicted HCA, whereas only IL-8 was a clinically useful marker of HCA in the cervical fluid.

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  • (PMID = 18050018.001).
  • [ISSN] 1476-7058
  • [Journal-full-title] The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • [ISO-abbreviation] J. Matern. Fetal. Neonatal. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Chemokine CCL2; 0 / Chemokines; 0 / Cytokines; 0 / Interleukins
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15. Hancock H, Campbell S, Ramprogus V, Kilgour J: Role development in health care assistants: the impact of education on practice. J Eval Clin Pract; 2005 Oct;11(5):489-98
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  • In nursing this has resulted in the delegation of 'nursing care' to health care assistants (HCAs).
  • This study sought to evaluate the impact of a HCA Development Programme on care delivery.
  • Secondly, it sought to understand the preparedness of HCAs to undertake the programme and the new roles set for them.
  • Semi-structured interviews were conducted with four HCAs, eight of each of their colleagues and four patients.
  • For part two, 12 HCAs were interviewed.
  • Data were analysed following the principles of thematic analysis.
  • FINDINGS: The findings for part one showed positive changes to the HCAs' role, which included skill and knowledge development, increased confidence and initiative and a more holistic approach to care.
  • The HCAs in part two voiced positive and negative views of their role development.
  • Of the 12 HCAs interviewed, eight were prepared to attend the programme, two were undecided, and two were reluctant to attend.
  • CONCLUSIONS: The findings indicated that while the HCA Development Programme positively influenced the role of the HCA, there was a need to invest more into preparation for the restructuring of roles.

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  • (PMID = 16164591.001).
  • [ISSN] 1356-1294
  • [Journal-full-title] Journal of evaluation in clinical practice
  • [ISO-abbreviation] J Eval Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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16. Henriksen U, Fog J, Loechel F, Praestegaard M: Profiling of multiple signal pathway activities by multiplexing antibody and GFP-based translocation assays. Comb Chem High Throughput Screen; 2008 Aug;11(7):537-44
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  • [Title] Profiling of multiple signal pathway activities by multiplexing antibody and GFP-based translocation assays.
  • Multiplexing of GFP based and immunofluorescence translocation assays enables easy acquisition of multiple readouts from the same cell in a single assay run.
  • Immunofluorescence assays monitor translocation, phosphorylation, and up/down regulation of endogenous proteins.
  • GFP-based assays monitor translocation of stably expressed GFP-fusion proteins.
  • Such assays may be multiplexed along (vertical), across (horizontal), and between (branch) signal pathways.
  • 1) The MK2-GFP assay monitors translocation of MK2-GFP from the nucleus to the cytoplasm in response to stimulation of the p38 pathway.
  • By applying different immunofluorescent assays to the MK2 assay, a multiplexed HCA system is created for deconvolution of p38 pathway activation including assay readouts for MK2, p38, NFkappaB, and c-Jun.
  • 2) A method for evaluating GPCR activation and internalization in a single assay run has been established by multiplexing GFP-based internalization assays with immunofluorescence assays for downstream transducers of GPCR activity: pCREB (cAMP sensor), NFATc1 (Ca(2+) sensor), and ERK (G-protein activation).
  • 3) Cell toxicity readouts can be linked to primary readouts of interest via acquisition of secondary parameters describing cellular morphology.
  • The ATF6 Redistribution assay is provided as an example.
  • These multiplex strategies provide a unique opportunity to enhance HCA data quality and save time during drug discovery.
  • From a single assay run, several assay readouts are obtained that help the user to deconvolute the mode of action of test compounds.
  • [MeSH-major] Antibodies / analysis. Green Fluorescent Proteins / analysis. Signal Transduction

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  • (PMID = 18694390.001).
  • [ISSN] 1386-2073
  • [Journal-full-title] Combinatorial chemistry & high throughput screening
  • [ISO-abbreviation] Comb. Chem. High Throughput Screen.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.- / Phosphotransferases
  • [Number-of-references] 23
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17. Pareja E, Cortés M, Rayon M, Moya A, Mir J: [Epithelioid hemangioendothelioma: an uncommon liver tumor]. Gastroenterol Hepatol; 2010 Jun-Jul;33(6):445-8
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  • [Title] [Epithelioid hemangioendothelioma: an uncommon liver tumor].
  • We report the case of a female patient who was referred to our unit because of a solid liver tumor, suggestive of metastasis.
  • After biopsy, the patient was diagnosed with epithelioid hemangioendothelioma of the liver.
  • Due to its rarity, this entity should be considered when a solitary hepatic lesion is detected and should be included in the differential diagnosis with liver metastases.
  • We highlight the infrequency of this tumor, its presentation as a solitary hepatic lesion and the indication of surgical treatment.
  • We describe the clinical and pathological characteristics of epithelioid hemangioendothelioma of the liver and report a new case of this entity.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adenoma / diagnosis. Atrophy. Biomarkers, Tumor / analysis. Carcinoma / secondary. Carcinoma, Hepatocellular / diagnosis. Diagnosis, Differential. Dyslipidemias / complications. Female. Humans. Incidental Findings. Kidney / pathology. Kidney / ultrasonography. Middle Aged. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2010 Elsevier España, S.L. All rights reserved.
  • (PMID = 20570012.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Abu Hilal M, Underwood T, Taylor MG, Hamdan K, Elberm H, Pearce NW: Bleeding and hemostasis in laparoscopic liver surgery. Surg Endosc; 2010 Mar;24(3):572-7
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  • [Title] Bleeding and hemostasis in laparoscopic liver surgery.
  • BACKGROUND: Minimally invasive liver resection is gaining acceptance worldwide.
  • The expansion of laparoscopic liver surgery will depend on the ability of expert surgeons and technological advances to address the management of bleeding and hemostasis with any new approach.
  • The 4(1/2)- year experience of a single center performing totally laparoscopic liver resections is presented, with special reference to the techniques the authors have developed to limit blood loss.
  • METHODS: Between 2003 and 2007, 80 patients underwent laparoscopic liver surgery for benign and malignant conditions including colorectal cancer metastases (n = 31), hepatocellular carcinoma (n = 6), neuroendocrine tumor (n = 3), cystic lesion (n = 10), adenoma (n = 8), and focal nodular hyperplasia (n = 7).
  • RESULTS: The median operative time was 150 min, and the median blood loss was 120 ml, with significantly more blood loss for right-sided transections than for the left liver surgery (821 vs 147 ml; p = 0.012).
  • CONCLUSIONS: The authors' experience with 80 totally laparoscopic liver resections over a 4(1/2)-year period demonstrates that laparoscopic liver surgery is safe and effective in experienced hands for major resections.
  • An intimate knowledge of the technology and techniques available for preventing and managing significant hemorrhage during laparoscopic liver resection is required for all surgeons performing laparoscopic liver surgery.
  • [MeSH-major] Hemorrhage / prevention & control. Hemostasis, Surgical. Hepatectomy / methods. Laparoscopy / methods. Liver Diseases / surgery

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  • (PMID = 19609610.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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19. Wong H, Lehman-McKeeman LD, Grubb MF, Grossman SJ, Bhaskaran VM, Solon EG, Shen HS, Gerson RJ, Car BD, Zhao B, Gemzik B: Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats. Toxicol Sci; 2005 Apr;84(2):232-42
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  • In subchronic toxicity studies in Sprague-Dawley rats, DMP 904 produced thyroid follicular cell hypertrophy and hyperplasia, and a low incidence of follicular cell adenoma.
  • This increase in Cl(tb) was associated with a significant increase in biliary clearance (Cl bile) of unconjugated [125I]T4 (nearly 80-times control rates) and increased liver:blood ratios of T4, suggestive of enhanced hepatic uptake of T4.
  • A single dose of DMP 904 (200 mg/kg) increased mRNA levels of hepatic cytochrome P450s (CYP 3A1 and CYP 2B1) and UDP-glucuronosyltransferases (UGT 1A1 and UGT 1A2).
  • Western blot analysis confirmed DMP 904 related increases in Oatp2 protein expression.
  • [MeSH-major] Corticotropin-Releasing Hormone / antagonists & inhibitors. Homeostasis / drug effects. Liver / drug effects. Pyrazoles / toxicity. Pyrimidines / toxicity. Thyroid Gland / drug effects. Thyroxine / blood. Triiodothyronine / metabolism

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  • (PMID = 15673846.001).
  • [ISSN] 1096-6080
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine; 0 / Organic Anion Transporters; 0 / Organic Cation Transport Proteins; 0 / Pyrazoles; 0 / Pyrimidines; 0 / RNA, Messenger; 0 / Slco1a4 protein, rat; 0 / Slco1c1 protein, rat; 06LU7C9H1V / Triiodothyronine; 9002-71-5 / Thyrotropin; 9015-71-8 / Corticotropin-Releasing Hormone; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 2.4.1.17 / Glucuronosyltransferase; Q51BO43MG4 / Thyroxine
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20. Lee KH, Lee BM: Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia. J Toxicol Environ Health A; 2007 Mar 1;70(5):388-92
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  • [Title] Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia.
  • (-)-Hydroxycitric acid (HCA) is widely used as an ingredient for nutritional supplements aimed at reducing food intake, appetite, and body weight.
  • In this study, the genotoxicity of HCA was evaluated using three tests: a bacterial reverse mutation assay (Ames test), an in vitro chromosomal aberration (CA) test, and an in vivo micronucleus (MN) test.
  • HCA was negative by the Ames test in the presence or absence of a microsomal metabolizing system.
  • HCA did not induce mutagenic activity in the Ames test, and no significant mutagenic potency was indicated by CA tests.
  • However, HCA significantly and dose-dependently increased the number of MNPCEs (micronucleated polychromatic erythrocytes/1000 polychromatic erythrocytes) and PCE/(PCE + NCE) ratios according to the MN test.
  • These results suggest that HCA preferentially induce micronuclei.
  • [MeSH-minor] Animals. Cell Line. Chromosome Aberrations / chemically induced. Cricetinae. Cricetulus. Garcinia cambogia. Mice. Mutagenicity Tests

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  • [CommentIn] J Toxicol Environ Health A. 2008;71(5):348-9; author reply 350-1 [18214809.001]
  • (PMID = 17454564.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Citrates; 8W94T9026R / hydroxycitric acid
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21. Marabelle A, Campagne D, Déchelotte P, Chipponi J, Deméocq F, Kanold J: Focal nodular hyperplasia of the liver in patients previously treated for pediatric neoplastic diseases. J Pediatr Hematol Oncol; 2008 Jul;30(7):546-9
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  • [Title] Focal nodular hyperplasia of the liver in patients previously treated for pediatric neoplastic diseases.
  • SUMMARY: The discovery of a liver nodule during postcancer follow-up suggests malignancy recurrence.
  • However, patients previously treated for pediatric cancers are at greater risk of developing benign hepatic tumors, raising the problems of getting an accurate noninvasive diagnosis.
  • Here we report 3 cases of focal nodular hyperplasia of the liver in patients previously treated for pediatric neoplastic diseases.
  • Only surgical resection led to positive diagnosis and prevented complications.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Focal Nodular Hyperplasia / diagnosis. Kidney Neoplasms / complications. Neuroblastoma / complications. Wilms Tumor / complications
  • [MeSH-minor] Adenoma / diagnosis. Adolescent. Adult. Biopsy, Needle. Bone Marrow Transplantation / adverse effects. Chromosomes, Human, Pair 7. Cicatrix / etiology. Diagnosis, Differential. Female. Graft vs Host Disease / pathology. Humans. Liver / pathology. Liver / radiography. Liver / ultrasonography. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Male. Monosomy. Pancytopenia / complications. Pancytopenia / genetics. Pancytopenia / surgery. Remission Induction


22. Lim SH, Feng L, Kemling JW, Musto CJ, Suslick KS: An optoelectronic nose for the detection of toxic gases. Nat Chem; 2009 Oct;1(7):562-7
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  • The sensor consists of a disposable array of cross-responsive nanoporous pigments with colours that are changed by diverse chemical interactions with analytes.
  • Different TICs were identified readily using a standard chemometric approach (hierarchical clustering analysis), with no misclassifications over 140 trials.

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  • (PMID = 20160982.001).
  • [ISSN] 1755-4349
  • [Journal-full-title] Nature chemistry
  • [ISO-abbreviation] Nat Chem
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES016011-03; United States / NIEHS NIH HHS / ES / U01 ES016011; United States / NIEHS NIH HHS / ES / U01 ES016011-03; United States / NIEHS NIH HHS / ES / U01ES016011
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gases
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23. Kacerovský M, Drahosová M, Hornychová H, Plísková L, Bolehovská R, Förstl M, Tosner J, Lesko D, Andrýs C: [Amniotic fluid interleukin 6 levels in preterm premature rupture of membranes]. Ceska Gynekol; 2009 Dec;74(6):403-10
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  • OBJECTIVE: The purpose of this study was to determinate the changes of amniotic fluid interleukin 6 (IL-6) concentrations in patients with preterm premature rupture of the membranes (PPROM), and in the presence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA).
  • The aim was to examine amniotic fluid IL-6 in relation to MIAC and HCA.
  • Twenty-eight of 37 patients placentas were collected and assessed for presence or absence HCA.
  • RESULTS: There was significant difference in the median amniotic fluid IL-6 concentration between patients with preterm rupture of the membranes with and without MIAC and HCA (patients with MIAC and HCA: median 915 pg/ml, range 651-1854 pg/ml vs. patients without MIAC and HCA: median 780 pg/ml, range 184-1059 pg/ml; p=0.047).
  • There was no significant difference in the median amniotic fluid IL-6 concentration between patients with preterm rupture of the membranes with and without HCA (patients with HCA: median 829 pg/ml, range 195-1992 pg/ml vs. patients without HCA: median 768 pg/ml, range 184-1890 pg/ml; p = 0.31).
  • CONCLUSION: Amniotic fluid IL-6 concentrations patients with PPROM with presence HCA and MIAC were significantly higher than IL-6 concentration patients without HCA and MIAC.

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  • (PMID = 21246786.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] CZE
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Interleukin-6
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24. Renaud S, Hays AP, Brannagan TH 3rd, Sander HW, Edgar M, Weimer LH, Olarte MR, Dalakas MC, Xiang Z, Danon MJ, Latov N: Gene expression profiling in chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol; 2005 Feb;159(1-2):203-14
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  • Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups.
  • Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis.
  • [MeSH-minor] Adult. Aged. Chronic Disease. Female. Humans. Male. Middle Aged. Oligonucleotide Array Sequence Analysis / methods. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction / genetics. Sural Nerve / pathology. Up-Regulation


25. Tränkenschuh W, Puls F, Christgen M, Albat C, Heim A, Poczkaj J, Fleming P, Kreipe H, Lehmann U: Frequent and distinct aberrations of DNA methylation patterns in fibrolamellar carcinoma of the liver. PLoS One; 2010;5(10):e13688
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  • [Title] Frequent and distinct aberrations of DNA methylation patterns in fibrolamellar carcinoma of the liver.
  • BACKGROUND: Gene silencing due to aberrant DNA methylation is a frequent event in hepatocellular carcinoma (HCC) and also in hepatocellular adenoma (HCA).
  • However, very little is known about epigenetic defects in fibrolamellar carcinoma (FLC), a rare variant of hepatocellular carcinoma that displays distinct clinical and morphological features.
  • METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the methylation status of the APC, CDH1, cyclinD2, GSTπ1, hsa-mir-9-1, hsa-mir-9-2, and RASSF1A gene in a series of 15 FLC and paired normal liver tissue specimens by quantitative high-resolution pyrosequencing.
  • Results were compared with common HCC arising in non-cirrhotic liver (n = 10).
  • [MeSH-major] DNA Methylation. Liver Neoplasms / genetics

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  • (PMID = 21060828.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2966398
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26. Magesh V, DurgaBhavani K, Senthilnathan P, Rajendran P, Sakthisekaran D: In vivo protective effect of crocetin on benzo(a)pyrene-induced lung cancer in Swiss albino mice. Phytother Res; 2009 Apr;23(4):533-9
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  • We evaluated crocetin in Swiss albino mice treated with the tobacco-specific carcinogen benzo(a)pyrene [B(a)P] for their ability to inhibit pulmonary adenoma formation and growth.
  • Crocetin (50 mg/kg body weight) reduced proliferating cells by 68% and 45% in 18 and 8 weeks of treatment respectively.
  • The levels of glycoproteins and polyamines were significantly altered in the B(a)P-induced animals than in crocetin treatment groups.
  • Taken together, these results indicate that crocetin was capable of inhibiting proliferation cells by inhibiting proliferating cells, glycoprotein and polyamine synthesis.
  • [MeSH-major] Adenoma / prevention & control. Antineoplastic Agents, Phytogenic / therapeutic use. Carotenoids / pharmacology. Lung Neoplasms / prevention & control
  • [MeSH-minor] Animals. Benzo(a)pyrene / adverse effects. Glycoproteins / analysis. Hexosamines / analysis. Liver / metabolism. Lung / metabolism. Lung / pathology. Male. Mice. Polyamines / analysis. Proliferating Cell Nuclear Antigen / analysis

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  • [Copyright] (c) 2008 John Wiley & Sons, Ltd.
  • (PMID = 19067387.001).
  • [ISSN] 1099-1573
  • [Journal-full-title] Phytotherapy research : PTR
  • [ISO-abbreviation] Phytother Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Glycoproteins; 0 / Hexosamines; 0 / Polyamines; 0 / Proliferating Cell Nuclear Antigen; 20TC155L9C / crocetin; 3417WMA06D / Benzo(a)pyrene; 36-88-4 / Carotenoids
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27. Puangsombat K, Smith JS: Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary. J Food Sci; 2010 Mar;75(2):T40-7
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  • Heterocyclic amines (HCAs) are mutagenic compounds formed during cooking muscle foods at high temperature.
  • Inhibition of HCAs by rosemary extracts were evaluated with beef patties cooked at 191 degrees C (375 degrees F) for 6 min each side and 204 degrees C (400 degrees F) for 5 min each side.
  • The 5 extracts were directly added to beef patties at 3 levels (0.05%, 0.2%, and 0.5%) before cooking and HCA contents were extracted and quantified.
  • There was no statistical difference in the inhibition of HCAs in the 0.05%, 0.2%, and 0.5% rosemary extracts.
  • When cooking at 204 degrees C (400 degrees F) for 5 min each side, rosemary extracts 10E and 20E were superior to rosemary extracts 100W, 30E, and 40E in inhibiting HCA formation.
  • The inhibiting effect of rosemary extracts on HCA formation corresponded to their antioxidant activity based on a DPPH scavenging assay.
  • It is possible that these compounds might act synergistically in inhibiting the formation of HCAs.
  • [MeSH-major] Antioxidants / pharmacology. Heterocyclic Compounds, 2-Ring / analysis. Meat Products / analysis. Plant Extracts / pharmacology. Rosmarinus
  • [MeSH-minor] Animals. Cattle. Cooking / methods. Ethanol. Food Analysis / methods. Food Handling / methods. Gas Chromatography-Mass Spectrometry / methods. Imidazoles / analysis. Quinoxalines / analysis. Solid Phase Microextraction / methods. Time Factors. Water

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  • (PMID = 20492265.001).
  • [ISSN] 1750-3841
  • [Journal-full-title] Journal of food science
  • [ISO-abbreviation] J. Food Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Heterocyclic Compounds, 2-Ring; 0 / Imidazoles; 0 / Plant Extracts; 0 / Quinoxalines; 059QF0KO0R / Water; 3K9958V90M / Ethanol; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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28. Silva JP, Fonseca Ld, Baumgratz JF, Castro RM, Franchi SM, Lianza AC, Vila JH: Hypoplastic left heart syndrome: the report of a surgical strategy and comparative results of Norwood x Norwood-Sano approach. Rev Bras Cir Cardiovasc; 2007 Apr-Jun;22(2):160-8
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  • [Title] Hypoplastic left heart syndrome: the report of a surgical strategy and comparative results of Norwood x Norwood-Sano approach.
  • OBJECTIVES: To report a surgical strategy for the Norwood procedure in the hypoplastic left heart syndrome (HLHS) that enables short hypothermic circulatory arrest time and aortic arch reconstruction with autologous pericardium patch.
  • Cannulation of the ductus arteriosus for systemic perfusion was the main part of the surgical strategy to reduce the hypothermic circulatory arrest time.
  • Hypothermic circulatory arrest times were 45.79+/-1.99 min and 36,8+/-1,52 min (p=0,0012), respectively.
  • CONCLUSIONS: This surgical strategy resulted in short circulatory arrest time, low mortality and low incidence of aortic coarctation.
  • [MeSH-major] Aortic Valve / surgery. Bioprosthesis. Heart Valve Prosthesis / standards. Hypoplastic Left Heart Syndrome / surgery. Pericardium / transplantation
  • [MeSH-minor] Anastomosis, Surgical. Brazil / epidemiology. Female. Heart Valve Prosthesis Implantation / mortality. Heart Ventricles / surgery. Humans. Infant, Newborn. Length of Stay. Male. Pulmonary Artery / surgery. Pulmonary Circulation. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17992320.001).
  • [Journal-full-title] Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular
  • [ISO-abbreviation] Rev Bras Cir Cardiovasc
  • [Language] eng; por
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Brazil
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29. Kobayashi S, Matsui O, Gabata T, Sanada J, Koda W, Minami T, Ryu Y: Radiological and histopathological manifestations of hepatocellular nodular lesions concomitant with various congenital and acquired hepatic hemodynamic abnormalities. Jpn J Radiol; 2009 Feb;27(2):53-68
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  • [Title] Radiological and histopathological manifestations of hepatocellular nodular lesions concomitant with various congenital and acquired hepatic hemodynamic abnormalities.
  • Congenital and acquired hepatic hemodynamic abnormalities are classified into four categories: hepatic arterial inflow disorder, portal vein inflow disorder, hepatic vein outflow disorder, and presence of a third inflow to the liver.
  • Although their detailed etiology is not fully understood, these hepatic hemodynamic abnormalities may cause the formation of hepatocellular nodules.
  • Recent advances in imaging modalities now enable visualization of these hepatocellular nodules concomitantly with the identification of various congenital and acquired hemodynamic abnormalities.
  • Most of these nodular lesions are benign hyperplastic nodules, such as focal nodular hyperplasia, nodular regenerative hyperplasia, and other types of regenerative nodules.
  • However, neoplastic nodules such as hepatic adenoma and hepatocellular carcinoma may also occur in conjunction with hepatic hemodynamic abnormalities.
  • Distinguishing neoplastic nodules, especially malignant liver tumors, from hyperplastic nodules is important.
  • Detection of intranodular Kupffer cells with superparamagnetic iron oxide enhanced magnetic resonance imaging is a key indicator that a nodule is regenerative rather than neoplastic.
  • [MeSH-major] Arteriovenous Malformations / diagnosis. Liver / abnormalities. Liver / blood supply. Liver Circulation. Liver Diseases / diagnosis
  • [MeSH-minor] Adenoma, Liver Cell / diagnosis. Adenoma, Liver Cell / pathology. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / pathology. Focal Nodular Hyperplasia / diagnosis. Focal Nodular Hyperplasia / pathology. Hemodynamics. Humans. Kupffer Cells / pathology. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 19373534.001).
  • [ISSN] 1867-1071
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 78
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30. Apostolakis E, Shuhaiber JH: Antegrade or retrograde cerebral perfusion as an adjunct during hypothermic circulatory arrest for aortic arch surgery. Expert Rev Cardiovasc Ther; 2007 Nov;5(6):1147-61
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  • [Title] Antegrade or retrograde cerebral perfusion as an adjunct during hypothermic circulatory arrest for aortic arch surgery.
  • Three methods of cerebral protection have been applied between 1975 and today: hypothermic circulatory arrest as a basic method, either alone or with antegrade cerebral perfusion (ACP), or retrograde cerebral perfusion (RCP) as an adjunctive method.
  • ACP obtains a near-physiologic brain perfusion, with homogenous distribution of blood throughout the capillary beds, and extends the safe time of hypothermic circulatory arrest to 80 min, allowing the completion of whatever aortic arch work is necessary.

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  • (PMID = 18035930.001).
  • [ISSN] 1744-8344
  • [Journal-full-title] Expert review of cardiovascular therapy
  • [ISO-abbreviation] Expert Rev Cardiovasc Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 92
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31. Ge M, Zhao H, Wang W, Zhang Z, Yu X, Li W: Terahertz time-domain spectroscopy of four hydroxycinnamic acid derivatives. J Biol Phys; 2006 Nov;32(5):403-12
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  • The well-resolved absorption spectra of the hydroxycinnamic acid (HCA) derivatives, caffeic acid, ferulic acid, sinapic acid and chlorogenic acid, were measured over the frequency region from 0.3 to 2.0 THz at 294 K with terahertz time-domain spectroscopy (THz-TDS).
  • Theoretical calculation was applied to assist the analysis and assignment of the individual THz absorption spectra of the HCA derivatives with density functional theory (DFT).
  • The real and imaginary parts of dielectric function of the four HCA derivatives were also obtained.

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  • (PMID = 19669446.001).
  • [ISSN] 0092-0606
  • [Journal-full-title] Journal of biological physics
  • [ISO-abbreviation] J Biol Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2651536
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32. Duffin C: Healthcare assistants seen as more involved in patient care than nurses. Nurs Stand; 2006 Aug 16;20(49):5
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  • Patients have said that healthcare assistants (HCAs), not nurses, give most of the direct care they receive in hospital, research published in this week's Nursing Standard reveals.

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  • (PMID = 28086443.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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33. Shum-Tim D, MacDonald D, Takayuki S, Laliberté E, Chen J, Jamal AM, Philip A, Platt R: Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest. Pediatr Crit Care Med; 2005 May;6(3):319-26
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  • [Title] Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest.
  • OBJECTIVE: The objective of this study was to evaluate the systemic and cerebral effects of different postoperative hematocrit management following cardiopulmonary bypass and deep hypothermic circulatory arrest.
  • INTERVENTIONS: Twelve piglets were subjected to cardiopulmonary bypass (hematocrit = 25%) and 100 mins of deep hypothermic circulatory arrest (15 degrees C).
  • Near-infrared spectroscopy and immunohistochemical assays for cerebral transforming growth factor-beta(1) and caspase-3 were performed.
  • CONCLUSIONS: Lower postoperative hematocrit was associated with increased fluid retention, lower perfusion pressure, and worse cerebrovascular injury following deep hypothermic circulatory arrest.
  • Postoperative hematocrit management may have profound systemic and cerebral effects after deep hypothermic circulatory arrest and merits further investigation.

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  • (PMID = 15857532.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins; 0 / Oxyhemoglobins; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1; 9008-02-0 / deoxyhemoglobin; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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34. Halstead JC, Etz C, Meier DM, Zhang N, Spielvogel D, Weisz D, Bodian C, Griepp RB: Perfusing the cold brain: optimal neuroprotection for aortic surgery. Ann Thorac Surg; 2007 Sep;84(3):768-74; discussion 774
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  • We used a survival porcine model to explore the physiologic characteristics and behavioral benefits of various protocols involving hypothermic circulatory arrest (HCA) and SCP.
  • METHODS: Thirty pigs (26.3 +/- 1.4 kg), cooled to 15 degrees C on cardiopulmonary bypass, using alpha-stat pH management (mean hematocrit 30%), were randomly allocated to differing brain protection strategies: 90 minutes of HCA (group A); 30 minutes of HCA, then 60 minutes of SCP (group B); or 90 minutes of SCP (group C).
  • RESULTS: Cerebral blood flow was significantly higher (p = 0.0001) during SCP (60 and 90 minutes) if preceded by HCA.
  • However, an initial period of HCA does not seem to impair late outcome; perhaps the elevated CBF and CMRO2 observed reflect a beneficial cerebral response to a recoverable insult.
  • Clearly, 90 minutes of HCA induces permanent brain injury, even in this carefully controlled setting.
  • [MeSH-major] Aorta / surgery. Cerebrovascular Circulation. Heart Arrest, Induced

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  • (PMID = 17720373.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] S88TT14065 / Oxygen
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35. Chen Y, Zhu SB, Xie MY, Nie SP, Liu W, Li C, Gong XF, Wang YX: Quality control and original discrimination of Ganoderma lucidum based on high-performance liquid chromatographic fingerprints and combined chemometrics methods. Anal Chim Acta; 2008 Aug 15;623(2):146-56
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  • Then different pattern recognition procedures, including hierarchical cluster analysis (HCA), principal component analysis (PCA), partial least squares-discrimination analysis (PLS-DA) and soft independent modeling of class analogy (SIMCA) were applied to classify the G. lucidum samples according to their cultivated origins.
  • Furthermore, four marker constituents were screened out to be the most discriminant variables, which could be applied to accurate discrimination and quality control of G. lucidum by quantitative analysis.
  • [MeSH-minor] Chromatography, High Pressure Liquid. Cluster Analysis. Discriminant Analysis. Pattern Recognition, Automated. Principal Component Analysis. Quality Control

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  • (PMID = 18620918.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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36. Sun Y, Sinicrope FA: Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells. Mol Cancer Ther; 2005 Jan;4(1):51-9
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  • [Title] Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells.
  • Sulindac sulfide inhibits cyclooxygenase (COX)-mediated prostaglandin synthesis and retards the growth of cultured colon cell lines primarily by inducing apoptosis.
  • Given the known role of mitogen-activated protein kinase (MAPK) in signal transduction and the regulation of cell survival and death, we determined the effect of sulindac sulfide on MAPK activation, COX-2 expression, and apoptosis induction in HCA-7 human colon cancer cells.
  • Similar results were seen in HCT-15 cells and also with the selective COX-2 inhibitor NS398.
  • [MeSH-minor] Antineoplastic Agents / toxicity. Cell Line, Tumor. Colonic Neoplasms. Cyclooxygenase Inhibitors / toxicity. Drug Synergism. Flavonoids / toxicity. Humans. Nitrobenzenes / toxicity. Sulfonamides / toxicity

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  • (PMID = 15657353.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK56378
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one; 0 / Antineoplastic Agents; 0 / Cyclooxygenase Inhibitors; 0 / Enzyme Inhibitors; 0 / Flavonoids; 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; 184SNS8VUH / Sulindac; 6UVA8S2DEY / sulindac sulfide; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 2.7.12.2 / MAP Kinase Kinase 1
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37. Brandt K, Langhans W, Geary N, Leonhardt M: Beneficial and deleterious effects of hydroxycitrate in rats fed a high-fructose diet. Nutrition; 2006 Sep;22(9):905-12
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  • OBJECTIVE: The present study assessed whether long-term supplementation of a high-fructose diet with hydroxycitrate (HCA), an inhibitor of de novo lipogenesis that is widely used as a non-prescription dietary aid, decreases food intake, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats.
  • METHODS: We examined the effects of HCA (1.8% of diet) on food intake, body weight gain, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats during a 4-wk period of ad libitum access to a 50% fructose diet after a 3-wk period of food restriction in which they lost about 20% of their body weight.
  • RESULTS: HCA decreased food intake and weight gain throughout the test and reduced visceral fat accumulation compared with control rats fed ad libitum (CON).
  • Rats that were pair-fed (PF) to the HCA rats showed similar decreases in weight gain and visceral fat.
  • HCA did not ameliorate the hypertriglyceridemia induced by high-fructose feeding.
  • HCA improved insulin sensitivity on day 10 in comparison with CON rats, but by day 27 insulin levels were similarly higher and liver glycogen levels were similarly lower in HCA and CON rats in comparison with PF rats.
  • Liver lipid content was elevated in HCA rats compared with CON and PF rats.
  • CONCLUSION: These findings indicate that, although HCA attenuates body weight gain and visceral fat accumulation by reducing food intake under these conditions, it has no lasting beneficial effects on hypertriglyceridemia and hyperinsulinemia and leads to the accumulation of liver lipids.
  • [MeSH-major] Citrates / administration & dosage. Energy Intake / drug effects. Fructose / administration & dosage. Intra-Abdominal Fat / drug effects. Liver / metabolism. Weight Gain / drug effects

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  • (PMID = 16829028.001).
  • [ISSN] 0899-9007
  • [Journal-full-title] Nutrition (Burbank, Los Angeles County, Calif.)
  • [ISO-abbreviation] Nutrition
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Citrates; 30237-26-4 / Fructose; 8W94T9026R / hydroxycitric acid
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38. Meybohm P, Hoffmann G, Renner J, Boening A, Cavus E, Steinfath M, Scholz J, Bein B: Measurement of blood flow index during antegrade selective cerebral perfusion with near-infrared spectroscopy in newborn piglets. Anesth Analg; 2008 Mar;106(3):795-803, table of contents
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  • BACKGROUND: Neonates with complex congenital heart defects have traditionally undergone surgery during deep hypothermic cardiac arrest (HCA).
  • We investigated SCP with different flow rates compared with HCA with respect to cerebral perfusion and tissue oxygenation as assessed by near-infrared spectroscopy.
  • METHODS: Twenty-one piglets were placed on cardiopulmonary bypass at 18 degrees C, then underwent either HCA or SCP at 25 or 50 mL x kg(-1) x min(-1) for 90 min.
  • RESULTS: Both BFI and FV(mean) increased significantly (126 +/- 27% of baseline; 19 +/- 2 cm/s) in the SCP 50 group compared with HCA (no flow) and SCP 25 (65 +/- 24%; 10 +/- 1 cm/s), respectively.
  • TOI increased in the SCP 50 group compared with baseline (74 +/- 4% vs 65 +/- 4%), and was higher compared with HCA (52 +/- 2%) and SCP 25 (59 +/- 2%).
  • CONCLUSIONS: Both BFI and FV(mean) suggested increased cerebral perfusion in the SCP 50 group compared with the HCA and SCP 25 groups.
  • TOI was significantly higher in both the SCP 25 and SCP 50 groups compared with HCA.
  • [MeSH-major] Brain / blood supply. Brain Ischemia / prevention & control. Cardiopulmonary Bypass / adverse effects. Cerebrovascular Circulation. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Monitoring, Intraoperative / methods. Perfusion / methods. Spectroscopy, Near-Infrared


39. Nishimura O, Suzuki T, Hosoba S, Takashima N, Hiramatsu N, Kinoshita T, Kambara A, Matsubayashi K, Asai T: [Acute type A aortic dissection, developed shortly after aortic valve replacement and coronary artery bypass grafting]. Kyobu Geka; 2010 Dec;63(13):1141-4
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  • Under hypothermic circulatory arrest with femoral arterial and venous cannulations, the ascending aorta was replaced and re-implantation of the saphenous vein graft was carried out.
  • [MeSH-major] Aneurysm, Dissecting / etiology. Aortic Aneurysm, Thoracic / etiology. Coronary Artery Bypass. Heart Valve Prosthesis Implantation
  • [MeSH-minor] Acute Disease. Aged. Angina Pectoris / surgery. Aortic Valve Insufficiency / surgery. Humans. Male. Postoperative Complications. Reoperation

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  • (PMID = 21174664.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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40. De Francesco MA, Gargiulo F, Schreiber C, Ciravolo G, Salinaro F, Manca N: Detection and genotyping of human papillomavirus in cervical samples from Italian patients. J Med Virol; 2005 Apr;75(4):588-92
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  • In order to assess the epidemiological incidence and frequency of different HPV types, we applied a polymerase chain reaction (PCR)-direct sequencing approach based on the use of MY09/MY11 primers as compared to Hybrid Capture assay.
  • [MeSH-minor] Adolescent. Adult. Carcinoma in Situ / virology. Female. Genotype. Humans. Italy. Middle Aged. Sequence Analysis, DNA

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15714493.001).
  • [ISSN] 0146-6615
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Galloro V: Emory, HCA to end venture. Cultural differences, control cited as obstacles. Mod Healthc; 2010 Jul 19;40(29):16
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  • [Title] Emory, HCA to end venture. Cultural differences, control cited as obstacles.

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  • (PMID = 20695116.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] United States
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42. De Felice C, Goldstein MR, Parrini S, Verrotti A, Criscuolo M, Latini G: Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis. Pediatr Crit Care Med; 2006 Mar;7(2):138-42
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  • OBJECTIVE: No reliable clinical markers of histologic chorioamnionitis (HCA), a major and often subclinical cause of prematurity leading to high neonatal morbidity and mortality, are available to date.
  • PATIENTS AND INTERVENTION: Pulse oximetry-derived signals (pulse rate, oxygen saturation, and perfusion index), recorded within the first 1.5 hrs of life, were analyzed for 110 very low-birth-weight infants, of whom 54 had histopathological evidence of HCA.
  • MEASUREMENTS AND MAIN RESULTS: Four different time series parameters were determined for nonlinear dynamical (NLD) analysis.
  • Significantly decreased Lempel-Ziv, Lyapunov largest exponent, and correlation dimension, with significantly increased Hurst values for heart rate and perfusion index (p < .00001), were observed in newborns with HCA.
  • Heart rate Lempel-Ziv </=0.218 showed 100% sensitivity (95% confidence interval, 98.8-100) and 100% specificity (95% confidence interval, 98.6-100) in distinguishing cases from controls, with positive and negative predictive values of 100% and 95.7%, respectively.
  • CONCLUSIONS: Our findings indicate that early autonomic tone balance abnormalities are present in newborns with HCA and suggest that early dynamic analysis of pulse oximetry signals could be useful in identifying affected infants.
  • [MeSH-major] Chorioamnionitis / diagnosis. Chorioamnionitis / pathology. Infant, Premature

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  • (PMID = 16474255.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Defrain C, Chang CY, Srikureja W, Nguyen PT, Gu M: Cytologic features and diagnostic pitfalls of primary ampullary tumors by endoscopic ultrasound-guided fine-needle aspiration biopsy. Cancer; 2005 Oct 25;105(5):289-97
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  • BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-guided FNAB) is highly sensitive and specific in cytologic diagnosis and clinical staging of malignant neoplasms of the gastrointestinal tract, pancreas, liver, and lymph nodes.
  • The number of passes necessary to arrive at a preliminary diagnosis during adequacy assessment was documented.
  • Atypical cells were found in six patients, four of which were suspicious for adenocarcinoma and two of which were consistent with reactive atypia.
  • Adenoma was diagnosed in two patients and carcinoid tumor in one.
  • Thirteen patients had a diagnosis that was negative for malignant cells.
  • The consistent cytologic features in specimens that were positive or suspicious for adenocarcinoma included high cellularity, single cells, 3-dimensional cell balls, high nuclear-to-cytoplasmic ratio, prominent nucleoli, coarse/uneven distribution of chromatin, and necrosis.
  • Adenoma presented a diagnostic challenge and endosonographic correlation was instrumental to increase the diagnostic accuracy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenoma / diagnosis. Adenoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / pathology

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  • (PMID = 15986397.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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44. Trask OJ, Nickischer D, Burton A, Williams RG, Kandasamy RA, Johnston PA, Johnston PA: High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer. Methods Mol Biol; 2009;565:159-86
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  • [Title] High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer.
  • The integration of fluorescent microscopy imaging technologies and image analysis into high-content screening (HCS) has been applied throughout the drug discovery pipeline to identify, evaluate, and advance compounds from early lead generation through preclinical candidate selection.
  • In this chapter we describe the development, validation, and implementation of an HCS assay to screen compounds from a kinase-focused small-molecule library to identify inhibitors of the p38 pathway using the GE InCell 3000 automated imaging platform.
  • The assay utilized a genetically modified HeLa cell line stably expressing mitogen-activated, protein-activating protein kinase-2 fused to enhanced green fluorescent protein (MK2-EGFP) and measured the subcellular distribution of the MK2-EGFP as a direct readout of p38 activation.
  • The MK2-EGFP translocation assay performed in 384-well glass bottom microtiter plates exhibited a robust Z-factor of 0.46 and reproducible EC50 and IC50 determinations for activators and inhibitors, respectively.
  • Thirty-one compounds exhibited IC50s less than 1 microM, and at least one novel structural class of p38 inhibitor was identified using this HCA/HCS chemical biology screening approach.
  • [MeSH-major] Drug Evaluation, Preclinical / methods. Enzyme Inhibitors / analysis. Microscopy, Confocal / methods. p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
  • [MeSH-minor] Calcium / metabolism. HeLa Cells. Humans

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  • (PMID = 19551362.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; SY7Q814VUP / Calcium
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45. Wu Y, Na N, Zhang S, Wang X, Liu D, Zhang X: Discrimination and identification of flavors with catalytic nanomaterial-based optical chemosensor array. Anal Chem; 2009 Feb 1;81(3):961-6
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  • Hierarchical cluster analysis (HCA) and linear discriminant analysis (LDA) were used to analyze the patterns.
  • [MeSH-major] Flavoring Agents / analysis. Luminescent Measurements / methods. Nanostructures / chemistry
  • [MeSH-minor] Catalysis. Discriminant Analysis. Metal Nanoparticles / chemistry. Nanotubes, Carbon / chemistry. Temperature. Time Factors

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  • (PMID = 19119818.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Flavoring Agents; 0 / Nanotubes, Carbon
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46. Inoue K, Shibutani M, Masutomi N, Toyoda K, Takagi H, Takahashi M, Fujimoto H, Hirose M, Nishikawa A: One-year chronic toxicity of madder color in F344 rats--induction of preneoplastic/neoplastic lesions in the kidney and liver. Food Chem Toxicol; 2008 Oct;46(10):3303-10
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  • [Title] One-year chronic toxicity of madder color in F344 rats--induction of preneoplastic/neoplastic lesions in the kidney and liver.
  • Relative weights of the liver were significantly increased from 1.0% in both sexes, and those of the kidney were significantly increased from 1.0% in males and from 0.2% in females.
  • Histopathologically, atypical renal tubule hyperplasias were increased at 1.0% or higher in both sexes in association with increase of cell proliferative activity in the tubules.
  • A renal cell adenoma was observed in a male rat receiving 5.0% MC.
  • In addition, glutathione S-transferase placental form-positive liver cell foci were significantly increased at 5.0% in both sexes.
  • These results indicate that MC has chronic toxicity targeting kidney, liver and blood cells.
  • Moreover, the results strongly suggest that MC may have the carcinogenic potential in the kidney and the liver.
  • [MeSH-major] Kidney Neoplasms / chemically induced. Liver Neoplasms / chemically induced. Plant Extracts / administration & dosage. Plant Extracts / toxicity. Precancerous Conditions / chemically induced. Rubia / toxicity
  • [MeSH-minor] Animals. Cell Proliferation. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Kidney / cytology. Male. Rats. Rats, Inbred F344. Toxicity Tests, Chronic

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  • (PMID = 18723070.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Plant Extracts; 0 / madder color
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47. Farruggia P, Alaggio R, Cardella F, Tropia S, Trizzino A, Ferrara F, D'Angelo P: Focal nodular hyperplasia of the liver: an unusual association with diabetes mellitus in a child and review of literature. Ital J Pediatr; 2010;36:41
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  • [Title] Focal nodular hyperplasia of the liver: an unusual association with diabetes mellitus in a child and review of literature.
  • Hepatic hemangioma, adenoma and focal nodular hyperplasia are the most frequent benign lesions of the liver, but they are all infrequent among pediatric population.
  • [MeSH-minor] Biopsy. Child. Diagnosis, Differential. Follow-Up Studies. Hepatectomy / methods. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 20504362.001).
  • [ISSN] 1824-7288
  • [Journal-full-title] Italian journal of pediatrics
  • [ISO-abbreviation] Ital J Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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48. Ruebel KH, Leontovich AA, Jin L, Stilling GA, Zhang H, Qian X, Nakamura N, Scheithauer BW, Kovacs K, Lloyd RV: Patterns of gene expression in pituitary carcinomas and adenomas analyzed by high-density oligonucleotide arrays, reverse transcriptase-quantitative PCR, and protein expression. Endocrine; 2006 Jun;29(3):435-44
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  • [Title] Patterns of gene expression in pituitary carcinomas and adenomas analyzed by high-density oligonucleotide arrays, reverse transcriptase-quantitative PCR, and protein expression.
  • To identify potential genes that may be important in pituitary tumor progression and carcinoma development, we used Affymetrix GeneChip HGU-133A-oligonucleotide arrays, which contain more than 15,000 characterized genes from the human genome to study gene expression in an ACTH pituitary carcinoma metastatic to the liver and four pituitary adenomas.
  • Reverse-transcriptase real-time quantitative- PCR (RT-qPCR) was then used to analyze 4 nonneoplastic pituitaries, 19 adenomas, and the ACTH carcinoma.
  • A larger series of pituitary adenomas and carcinomas were also analyzed for protein expression using tissue microarrays (TMA) (n = 233) and by Western blotting (n = 18).
  • There were 4298 genes that were differentially expressed among the adenomas compared to the carcinoma, with 2057 genes overexpressed and 2241 genes underexpressed in the adenomas.
  • The beta-galactoside binding protein galactin-3 was underexpressed in some adenomas compared to the carcinomas.
  • The human achaetescute homolog-1 ASCL1 (hASH-1) gene was also underexpressed in some adenomas compared to the carcinoma.
  • ID2, which has an important role in cell development and tumorigenesis, was underexpressed in some adenomas compared to the carcinomas.
  • Transducin-like enhancer of split four/ Groucho (TLE-4) was over-expressed in adenomas compared to the ACTH carcinoma.
  • The differential expression of these genes was validated by RT-qPCR, by immunohistochemistry using TMA and by Western blotting.
  • [MeSH-major] Adenoma / genetics. Carcinoma / genetics. Gene Expression Profiling / methods. Oligonucleotide Array Sequence Analysis / methods. Pituitary Neoplasms / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods
  • [MeSH-minor] ACTH-Secreting Pituitary Adenoma / metabolism. Blotting, Western. DNA-Binding Proteins / metabolism. Follicle Stimulating Hormone / secretion. GRB2 Adaptor Protein / metabolism. Growth Hormone-Secreting Pituitary Adenoma / metabolism. Humans. Immunohistochemistry. Inhibitor of Differentiation Protein 2 / metabolism. Luteinizing Hormone / secretion. Nuclear Proteins / metabolism. Prolactinoma / metabolism. Repressor Proteins / metabolism

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  • (PMID = 16943582.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 90249
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / GRB2 Adaptor Protein; 0 / GRB2 protein, human; 0 / ID2 protein, human; 0 / Inhibitor of Differentiation Protein 2; 0 / Nuclear Proteins; 0 / Repressor Proteins; 0 / TLE4 protein, human; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone
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49. Basaran I, Sinan S, Cakir U, Bulut M, Arslan O, Ozensoy O: In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds. J Enzyme Inhib Med Chem; 2008 Feb;23(1):32-6
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  • These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B.

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  • (PMID = 18341250.001).
  • [ISSN] 1475-6366
  • [Journal-full-title] Journal of enzyme inhibition and medicinal chemistry
  • [ISO-abbreviation] J Enzyme Inhib Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Coumarins; 0 / Enzyme Inhibitors; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II
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50. Maillette de Buy Wenniger L, Terpstra V, Beuers U: Focal nodular hyperplasia and hepatic adenoma: epidemiology and pathology. Dig Surg; 2010;27(1):24-31
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  • [Title] Focal nodular hyperplasia and hepatic adenoma: epidemiology and pathology.
  • Focal nodular hyperplasia (FNH) and hepatic adenoma (HA) represent the most frequent non-vascular benign liver tumors.
  • FNH is the most common non-vascular benign tumor of the liver.
  • HA is a rare monoclonal, but benign liver tumor primarily found in young females using estrogen-containing contraceptives.
  • Although its exact etiology is unknown, a direct link between sex steroid exposure and the uncontrolled hepatocellular growth is suspected.
  • [MeSH-major] Focal Nodular Hyperplasia / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / pathology. Female. Humans

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20357448.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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51. Harris JK, Froehlich F, Wietlisbach V, Burnand B, Gonvers JJ, Vader JP: Factors associated with the technical performance of colonoscopy: An EPAGE Study. Dig Liver Dis; 2007 Jul;39(7):678-89
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  • AIMS: To determine factors associated with three performance indicators of colonoscopy: complete colonoscopy, adenomatous polyp diagnosis, and duration.
  • METHODS: This prospective observational study used multiple variable regression analyses to identify determinants of the quality indicators.
  • Patients from centres where over 50% of the endoscopists were of senior rank were roughly twice as likely to have an adenoma diagnosed, and longer average withdrawal duration (odds ratio: 1.08, 95% confidence interval: 1.07-1.09) was associated with more frequent adenoma diagnoses.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Colonoscopes. Colonoscopy / standards. Colorectal Neoplasms / diagnosis. Quality Indicators, Health Care

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  • [CommentIn] Dig Liver Dis. 2007 Jul;39(7):690-1 [17531552.001]
  • (PMID = 17434349.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] Netherlands
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52. Tanaka S, Tatsuguchi A, Futagami S, Gudis K, Wada K, Seo T, Mitsui K, Yonezawa M, Nagata K, Fujimori S, Tsukui T, Kishida T, Sakamoto C: Monocyte chemoattractant protein 1 and macrophage cyclooxygenase 2 expression in colonic adenoma. Gut; 2006 Jan;55(1):54-61
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  • [Title] Monocyte chemoattractant protein 1 and macrophage cyclooxygenase 2 expression in colonic adenoma.
  • BACKGROUND AND AIMS: Cyclooxygenase 2 (COX-2) expression in subepithelial macrophages of colorectal adenoma has been suggested as the first in a series of steps leading to colorectal tumorigenesis.
  • We tested the hypothesis that chemokines released from human colorectal adenoma epithelium might be involved in COX-2 expression in macrophages of the lamina propria.
  • METHODS: Endoscopic samples of sporadic colorectal adenomas were tested by enzyme linked immunosorbent assay for chemokines involved in macrophage chemotaxis.
  • Localisation of adenoma macrophage chemoattractant protein 1 (MCP-1) and COX-2 were determined by immunohistochemistry.
  • RESULTS: MCP-1 levels were markedly higher in adenoma with mild-moderate dysplasia (129.7 (19.9) pg/mg protein) and severe dysplasia (227.9 (35.4) pg/mg protein) than in normal colonic mucosa (55.8 (4.2) pg/mg protein).
  • Other chemokine levels, macrophage inflammatory proteins (MIP)-1alpha and MIP-1beta, and the chemokine regulated on activation of normal T cell expressed and secreted (RANTES) did not vary significantly between adenoma and normal mucosa.
  • MCP-1 levels in both adenoma and normal colonic mucosa increased significantly three hours after tissue cultivation in vitro.
  • MCP-1 immunoreactivity was restricted to the adenoma epithelium, with no reactivity seen in adjacent normal epithelial cells.
  • Addition of exogenous PGE(2) reversed this inhibitory effect on VEGF release, suggesting that MCP-1 in adenoma epithelial cells might be involved in COX-2 expression and subsequent macrophage activation.
  • CONCLUSIONS: MCP-1 in colorectal adenoma epithelial cells might be involved in macrophage migration and COX-2 expression, leading to the subsequent development of colonic adenoma.
  • [MeSH-major] Adenoma / metabolism. Chemokine CCL2 / metabolism. Colorectal Neoplasms / metabolism. Cyclooxygenase 2 / metabolism. Macrophages / enzymology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Celecoxib. Cells, Cultured. Chemokines / metabolism. Cyclooxygenase 1 / metabolism. Cyclooxygenase Inhibitors / pharmacology. Dinoprostone / metabolism. Dinoprostone / pharmacology. Enzyme-Linked Immunosorbent Assay / methods. Female. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Pyrazoles / pharmacology. Sulfonamides / pharmacology. Tissue Culture Techniques. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 16085694.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Chemokine CCL2; 0 / Chemokines; 0 / Cyclooxygenase Inhibitors; 0 / Neoplasm Proteins; 0 / Pyrazoles; 0 / Sulfonamides; 0 / Vascular Endothelial Growth Factor A; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; JCX84Q7J1L / Celecoxib; K7Q1JQR04M / Dinoprostone
  • [Other-IDs] NLM/ PMC1856393
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53. Fichera A, Little N, Dougherty U, Mustafi R, Cerda S, Li YC, Delgado J, Arora A, Campbell LK, Joseph L, Hart J, Noffsinger A, Bissonnette M: A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model. J Surg Res; 2007 Oct;142(2):239-45
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  • Our aim was to evaluate the anti-inflammatory and chemopreventive efficacy of the vitamin D analogue Ro26-2198 in the AOM/DSS model and in vitro in HCA-7 colon cancer cells.
  • For in vitro studies, HCA-7 cells were treated with Ro26-2198 followed by interleukin-1beta (IL-1beta).
  • Proliferation was measured by WST-1 assay.
  • In vitro, Ro26-2198 inhibited IL-1beta-induced ERK activation and COX-2 induction and decreased HCA-7 cell proliferation.
  • [MeSH-minor] Animals. Anti-Inflammatory Agents / pharmacology. Cell Division / drug effects. Cell Line, Tumor. Colon / metabolism. Colon / pathology. Cyclooxygenase 2 / metabolism. Disease Models, Animal. Extracellular Signal-Regulated MAP Kinases / metabolism. Humans. Interleukin-1beta / pharmacology. MAP Kinase Signaling System / drug effects. Male. Mice. Mice, Inbred A. Proto-Oncogene Proteins c-myc / metabolism. Up-Regulation / drug effects

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  • (PMID = 17574271.001).
  • [ISSN] 0022-4804
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA036745; United States / NIDDK NIH HHS / DK / DK42086
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3; 0 / Anti-Inflammatory Agents; 0 / Interleukin-1beta; 0 / Proto-Oncogene Proteins c-myc; 1C6V77QF41 / Cholecalciferol; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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54. Ueda T, Taguchi S, Inoue Y, Kashima I: Hypothermic circulatory arrest through a left thoracotomy in a 12-year-old child with aortic coarctation. Interact Cardiovasc Thorac Surg; 2007 Feb;6(1):85-6
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  • [Title] Hypothermic circulatory arrest through a left thoracotomy in a 12-year-old child with aortic coarctation.
  • Surgical correction of adult complex aortic coarctation using hypothermic circulatory arrest often requires central cannulation to secure cerebral perfusion.
  • [MeSH-major] Aortic Coarctation / surgery. Heart Arrest, Induced. Hypothermia, Induced. Thoracotomy / methods

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  • (PMID = 17669776.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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55. Kogure T, Ueno Y, Sekiguchi S, Ishida K, Igarashi T, Wakui Y, Iwasaki T, Shimosegawa T: Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma. World J Gastroenterol; 2009 Mar 14;15(10):1267-72
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  • [Title] Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma.
  • A liver tumor 35 mm in diameter was found incidentally in a 40-year-old woman who had no history of liver diseases or the use of oral contraceptives.
  • Radiological diagnostics showed the typical findings of liver cell adenoma (LCA).
  • Dynamic computed tomography revealed that the tumor showed a homogenous enhancement in the arterial phase and almost the same enhancement as the surrounding liver parenchyma in the delayed phase.
  • A benign fat containing liver tumor was suggested.
  • However, radiological findings altered, which caused us to suspect that a well-differentiated hepatocellular carcinoma (HCC) containing fat was becoming dedifferentiated.

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  • (PMID = 19291830.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095817
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2658857
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56. Kim SA, Sung YK, Kwon BM, Yoon JH, Lee H, Ahn SG, Hong SH: 2'-Hydroxycinnamaldehyde shows antitumor activity against oral cancer in vitro and in vivo in a rat tumor model. Anticancer Res; 2010 Feb;30(2):489-94
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  • BACKGROUND: 2'-Hydroxycinnamaldehyde (HCA) exerts antitumor activity against several human cancer cell lines.
  • MATERIALS AND METHODS: The antitumor activity of HCA was assessed in oral cancer cell lines and in a rat oral tumor model.
  • RESULTS: Cell cycle analysis confirmed that HCA showed anti-proliferative activity via cell cycle arrest at the G(2)/M-phase and increased the number of cells in the sub-G(1) (apoptotic cells) phase in SCC-15 and HEp-2 oral cancer cells.
  • Additionally, direct injection of HCA into an RK3E-ras-Fluc-induced tumor significantly inhibited growth of the tumor mass.
  • Histological analysis showed that HCA decreased tumor cell proliferation and induced apoptosis in a rat tumor model.
  • CONCLUSION: Taken together, these observations suggest the potential value of HCA as a candidate for the treatment of oral cancer.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Apoptosis / drug effects. Cell Cycle / drug effects. Cinnamates / pharmacology. Mouth Neoplasms / drug therapy. Xenograft Model Antitumor Assays
  • [MeSH-minor] Animals. Blotting, Western. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / pathology. Cell Proliferation / drug effects. Humans. Immunoenzyme Techniques. In Vitro Techniques. Male. Rats. Rats, Sprague-Dawley

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  • (PMID = 20332459.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cinnamates; 0 / p-hydroxycinnamaldehyde
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57. National Toxicology Program: Toxicology and carcinogenesis studies of formamide (Cas No. 75-12-7) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser; 2008 Jul;(541):1-192
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  • The incidences of hemangiosarcoma of the liver occurred with a positive trend in males, and the incidences were significantly increased in the 40 and 80 mg/kg groups.
  • The incidence of hepatocellular adenoma or carcinoma (combined) in 80 mg/kg females was significantly increased.
  • The incidence of hematopoietic cell proliferation of the spleen was significantly increased in 80 mg/kg males.
  • GENETIC TOXICOLOGY: Formamide gave no evidence for mutagenicity in a series of short-term assays.
  • In three independent Ames assays, formamide was not mutagenic in any of several strains of S. typhimurium tested with and without rat or hamster liver S9 activation enzymes or in E. coli strain WP uvrA pKM101 tested with and without 10% rat liver S9.
  • Negative results were obtained in a test for induction of sex-linked recessive lethal mutations in germ cells of male D. melanogaster treated with formamide either by feeding or injection.
  • There was clear evidence of carcinogenic activity of formamide in male B6C3F1 mice based on increased incidences of hemangiosarcoma of the liver.
  • There was equivocal evidence of carcinogenic activity of formamide in female B6C3F1 mice based on increased incidences of hepatocellular adenoma or carcinoma (combined).
  • Mineralization of the testicular arteries and tunic and hematopoietic cell proliferation of the spleen in male mice were also associated with administration of formamide.
  • [MeSH-minor] Administration, Oral. Animals. Body Weight / drug effects. Bone Marrow / drug effects. Bone Marrow / pathology. Calcinosis / chemically induced. Calcinosis / pathology. Female. Hyperplasia. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Male. Mice. Mice, Inbred Strains. Mutagenicity Tests. Rats. Rats, Inbred F344. Spleen / drug effects. Spleen / pathology. Testis / drug effects. Testis / pathology

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  • (PMID = 18716632.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Environmental Pollutants; 0 / Formamides; 4781T907ZS / formamide
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58. Muniz Filho RC, de Sousa SA, Pereira Fda S, Ferreira MM: Theoretical study of acid-catalyzed hydrolysis of epoxides. J Phys Chem A; 2010 Apr 22;114(15):5187-94
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  • By using chemometric tools, hierarchical cluster analysis (HCA), and principal component analysis (PCA), the MP2/6-311++G** level of theory was selected from HF, MP2, and DFT as the best method to describe the geometry of the basic skeleton (oxirane).
  • In the S(N)1 mechanism, the existence of the typical carbocation was not observed, and furthermore, the possibility of epoxide conversion to a protonated aldehyde was indicated, even in the presence of a water molecule (nucleophile).

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  • (PMID = 20334442.001).
  • [ISSN] 1520-5215
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Grazioli L, Morana G, Kirchin MA, Schneider G: Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenate dimeglumine-enhanced MR imaging: prospective study. Radiology; 2005 Jul;236(1):166-77
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  • [Title] Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenate dimeglumine-enhanced MR imaging: prospective study.
  • PURPOSE: To prospectively determine the accuracy of differentiating benign focal nodular hyperplasia (FNH) from hepatic adenoma (HA) and liver adenomatosis (LA) by using gadobenate dimeglumine-enhanced magnetic resonance (MR) imaging.
  • The enhancement of 235 lesions (128 FNH, 32 HA, and 75 LA lesions) relative to the normal liver parenchyma was assessed.
  • [MeSH-major] Adenoma / diagnosis. Focal Nodular Hyperplasia / diagnosis. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging / methods. Meglumine / analogs & derivatives. Organometallic Compounds
  • [MeSH-minor] Adult. Chi-Square Distribution. Contrast Media. Diagnosis, Differential. Female. Humans. Image Processing, Computer-Assisted. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Sensitivity and Specificity

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  • [Copyright] Copyright RSNA, 2005
  • (PMID = 15955857.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 15G12L5X8K / gadobenic acid; 6HG8UB2MUY / Meglumine
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60. Mazzei P, Francesca N, Moschetti G, Piccolo A: NMR spectroscopy evaluation of direct relationship between soils and molecular composition of red wines from Aglianico grapes. Anal Chim Acta; 2010 Jul 19;673(2):167-72
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  • The careful subtraction of water and ethanol signals from NMR spectra allowed to statistically recognize the metabolites to be employed in multivariate statistical methods: Principal Component Analysis (PCA), Discriminant Analysis (DA) and Hierarchical Clustering Analysis (HCA).
  • All multivariate analyses confirmed that the differentiation among the wines were related to micro-climate, and carbonate, clay, and organic matter content of soils.

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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20599031.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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61. Karni M, Bernasconi CF, Rappoport Z: Role of negative hyperconjugation and anomeric effects in the stabilization of the intermediate in SNV reactions. J Org Chem; 2008 Apr 18;73(8):2980-94
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  • The hyperconjugation ability (HCA) (i.e., the stabilization due to 2p(Calpha) --> sigma*(Cbeta-X) interaction) in 8b-8d follows the order (for X, kcal/mol) CH3S (8.5) > CF3CH2O (7.6) approximately CH3O (7.5).
  • The HCA in 8b-8d is significantly smaller than that in 7b-7d due to charge delocalization in Mu in the former.

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  • (PMID = 18376875.001).
  • [ISSN] 0022-3263
  • [Journal-full-title] The Journal of organic chemistry
  • [ISO-abbreviation] J. Org. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Anderl JL, Redpath S, Ball AJ: A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity. J Vis Exp; 2009;(27)
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  • [Title] A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity.
  • High Content Analysis (HCA) assays combine cells and detection reagents with automated imaging and powerful image analysis algorithms, allowing measurement of multiple cellular phenotypes within a single assay.
  • In this study, we utilized HCA to develop a novel assay for neurotoxicity.
  • Recently, the application of HCA to neuronal screening has been reported.
  • By labeling neuronal cells with betaIII-tubulin, HCA assays can provide high-throughput, non-subjective, quantitative measurements of parameters such as neuronal number, neurite count and neurite length, all of which can indicate neurotoxic effects.
  • Astrocytes have an integral role in the maintenance of central nervous system (CNS) homeostasis, and are associated with both neuroprotection and neurodegradation when they are activated in response to toxic substances or disease states.
  • This approach is limited by an inability to provide information on cellular localization, morphology and cell number.
  • We determined that HCA could be used to overcome these limitations and to simultaneously measure multiple features associated with gliosis - changes in GFAP expression, astrocyte hypertrophy, and astrocyte proliferation - within a single assay.
  • Recent studies have suggested that the use of astrocytes in an in vitro neurotoxicity test system may prove more relevant to human CNS structure and function than neuronal cells alone.
  • Accordingly, we have developed an HCA assay for co-culture of neurons and astrocytes, comprised of protocols and validated, target-specific detection reagents for profiling betaIII-tubulin and glial fibrillary acidic protein (GFAP).
  • This assay enables simultaneous analysis of neurotoxicity, neurite outgrowth, gliosis, neuronal and astrocytic morphology and neuronal and astrocytic development in a wide variety of cellular models, representing a novel, non-subjective, high-throughput assay for neurotoxicity assessment.
  • The assay holds great potential for enhanced detection of neurotoxicity and improved productivity in neuroscience research and drug discovery.

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  • (PMID = 19417729.001).
  • [ISSN] 1940-087X
  • [Journal-full-title] Journal of visualized experiments : JoVE
  • [ISO-abbreviation] J Vis Exp
  • [Language] eng
  • [Publication-type] Journal Article; Video-Audio Media
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3253581
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63. Jeon YK, Cheon JE, Kim SK, Wang KC, Cho BK, Park SH: Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization. Mod Pathol; 2008 Nov;21(11):1345-56
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  • [Title] Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization.
  • The presence of a pilomyxoid area was associated with shorter survival.
  • An unsupervised hierarchical clustering analysis classified the cases into three clusters: one pilomyxoid astrocytoma patient into one cluster, two pilomyxoid astrocytoma patients into another cluster, and six pilocytic astrocytoma patients and one pilomyxoid astrocytoma patient into the third cluster.
  • In conclusion, the presence of mixed-form pilomyxoid astrocytoma, the acquisition of pilocytic astrocytoma features in a recurrent tumor in pure-form pilomyxoid astrocytoma, and the above results of the genome-wide gene copy number analysis suggest that pilomyxoid astrocytoma might be a pathologically and genetically related, aggressive variant of pilocytic astrocytoma with partially different genetic alterations.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Brain / pathology. Child. Child, Preschool. Clone Cells. DNA, Neoplasm / genetics. Female. Humans. Immunoenzyme Techniques. Infant. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Survival Rate. Young Adult

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  • (PMID = 18622384.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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64. Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR: Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res; 2007 May 15;67(10):4586-94
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  • [Title] Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis.
  • Hepatocellular carcinoma (HCC) with p53 mutations is usually characterized by extensive chromosomal instability (CIN), whereas those with beta-catenin mutations have relatively less CIN and the molecular pathogenesis of these tumors is unknown.
  • Methylation of 21 genetic loci was quantitated using combined bisulfite restriction analysis.
  • Using hierarchical clustering analysis based upon the quantification of methylation levels, all HCCs were segregated into two groups characterized by either limited or extensive methylation.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. Cell Transformation, Neoplastic / genetics. DNA Methylation. Liver Neoplasms / genetics. beta Catenin / genetics

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  • [ErratumIn] Cancer Res. 2007 Jun 15;67(12):5998. Ajay, Goel [corrected to Goel, Ajay]
  • (PMID = 17510384.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA72851; United States / NCI NIH HHS / CA / R01 CA98572
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / beta Catenin
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65. Panos A, Murith N, Bednarkiewicz M, Khatchatourov G: Axillary cerebral perfusion for arch surgery in acute type A dissection under moderate hypothermia. Eur J Cardiothorac Surg; 2006 Jun;29(6):1036-9
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  • Adequate brain protection is essential and commonly performed by either antegrade selective perfusion of the brachiocephalic arteries or an interval of profound hypothermic circulatory arrest.
  • The mean duration of circulatory arrest of the lower body and brain perfusion was 39.7 (range, 24-55 min).
  • CONCLUSIONS: The absence of any major permanent neurologic deficit or any visceral damages in our patients suggests that continuous moderate hypothermic cerebral perfusion, with an interval of circulatory arrest of the lower body, is adequate for acute type A aortic dissection surgery, allowing safe open repair of the distal aortic arch.
  • [MeSH-minor] Acute Disease. Adult. Aged. Aged, 80 and over. Axillary Artery. Brain Ischemia / prevention & control. Cardiopulmonary Bypass / methods. Catheterization, Peripheral / methods. Female. Humans. Male. Middle Aged. Perfusion / methods. Treatment Outcome

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  • [CommentIn] Eur J Cardiothorac Surg. 2006 Nov;30(5):815-6; author reply 816-7 [16956768.001]
  • [CommentIn] Eur J Cardiothorac Surg. 2006 Jun;29(6):1039-40 [16675223.001]
  • (PMID = 16675240.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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66. Hidayat W, Shakaff AY, Ahmad MN, Adom AH: Classification of agarwood oil using an electronic nose. Sensors (Basel); 2010;10(5):4675-85
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  • Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA), were used to classify different types of oil.
  • The HCA produced a dendrogram showing the separation of e-nose data into three different groups of oils.
  • [MeSH-major] Electronic Nose. Plant Oils / analysis. Thymelaeaceae / chemistry
  • [MeSH-minor] Algorithms. Cluster Analysis. Neural Networks (Computer). Odorants / analysis. Principal Component Analysis

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  • (PMID = 22399899.001).
  • [ISSN] 1424-8220
  • [Journal-full-title] Sensors (Basel, Switzerland)
  • [ISO-abbreviation] Sensors (Basel)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Plant Oils
  • [Other-IDs] NLM/ PMC3292139
  • [Keywords] NOTNLM ; ANN (major topic) / HCA (major topic) / PCA (major topic) / agarwood oil (major topic) / dimensionality reduction (major topic) / e-nose (major topic)
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67. Kang M, Akbarali HI: Denitration of L-type calcium channel. FEBS Lett; 2008 Sep 3;582(20):3033-6
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  • Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCa(v)1.2b.
  • Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Ca(v)1.2 in a 1D gel assay.
  • Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates.

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  • (PMID = 18675806.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK046367-17; United States / NIDDK NIH HHS / DK / R01 DK046367; United States / NIDDK NIH HHS / DK / DK46367; United States / NIDDK NIH HHS / DK / R01 DK046367-17
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CACNA1C protein, human; 0 / Calcium Channels, L-Type; 0 / Nitrates; 3604-79-3 / 3-nitrotyrosine; 42HK56048U / Tyrosine
  • [Other-IDs] NLM/ NIHMS68998; NLM/ PMC2533528
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68. Yan S, Luo G, Wang Y, Cheng Y: Simultaneous determination of nine components in Qingkailing injection by HPLC/ELSD/DAD and its application to the quality control. J Pharm Biomed Anal; 2006 Mar 3;40(4):889-95
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  • This assay was fully validated in respect to precision, repeatability and accuracy.
  • The proposed method was successfully applied to quantify the nine ingredients in 19 different Qingkailing injection samples and by principal component analysis (PCA) and hierarchical clustering analysis (HCA), it demonstrated significant variations in the content of these compounds in the samples from different manufacturers and preparation procedures.
  • [MeSH-minor] Cluster Analysis. Light. Principal Component Analysis. Quality Control. Reproducibility of Results. Scattering, Radiation. Spectrophotometry, Ultraviolet

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  • (PMID = 16257167.001).
  • [ISSN] 0731-7085
  • [Journal-full-title] Journal of pharmaceutical and biomedical analysis
  • [ISO-abbreviation] J Pharm Biomed Anal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Qingkailing
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69. Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Tsuneyama K, Takano Y: Low expression of FHIT and PTEN correlates with malignancy of gastric carcinomas: tissue-array findings. Appl Immunohistochem Mol Morphol; 2007 Dec;15(4):432-40
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  • To clarify the roles of FHIT (fragile histidine triad) and PTEN (phosphatase and tensin homology deleted from human chromosome 10) expression in the genesis and progression of gastric cancers, we examined expression of FHIT and PTEN on tissue microarray containing gastric normal mucosa (n=49), adenoma (n=49), noncancerous mucosa adjacent to carcinoma (n=84) and carcinoma (n=249) by immunohistochemistry.
  • The results showed expression of FHIT and PTEN were lower in gastric carcinoma than those in normal mucosa, noncancerous mucosa adjacent to carcinoma and adenoma of the stomach (P<0.05).
  • FHIT and PTEN expression showed a significantly negative association with depth of invasion, lymphatic invasion, and lymph node metastasis, liver metastasis, and Union Internationale Contre le Cancer staging of gastric carcinoma (P<0.05).
  • It was suggested that down-regulated expression of FHIT and PTEN contributed to gastric carcinogenesis possibly by involving in the imbalance between apoptosis and proliferation of cells.

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  • (PMID = 18091387.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / fragile histidine triad protein; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 3.6.- / Acid Anhydride Hydrolases
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70. Galusca B, Dumollard JM, Lassandre S, Niveleau A, Prades JM, Estour B, Peoc'h M: Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia. Virchows Arch; 2005 Jul;447(1):18-23
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  • [Title] Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia.
  • The study aimed to evaluate the status of global DNA methylation in several types of thyroid tumors using a monoclonal antibody specific for 5-methylcytidine (5-mc) and to define the diagnosis potential of this marker.
  • 5-mc immunostaining scores were calculated in 17 papillary thyroid carcinomas (PTC), 6 follicular thyroid carcinomas (FTC), 16 follicular adenomas (FA), 19 nodular goiters (NG) and ten Hürthle cells adenomas (HCA).
  • Computerized image analysis showed a significant lower level of 5-mc immunostaining in thyroid carcinoma when compared with benign tumors or adjacent normal thyroid parenchyma (P<0.0001).
  • Overall, 5-mc accuracy to distinguish malign from benign thyroid tumors was similar to that of galectin-3 (89% versus 87%, P>0.05).
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. DNA Methylation. Goiter, Nodular / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Epigenesis, Genetic. Galectin 3 / analysis. Humans. Image Processing, Computer-Assisted. Immunohistochemistry. Reproducibility of Results

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  • (PMID = 15891902.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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71. Riener MO, Fritzsche FR, Soll C, Pestalozzi BC, Probst-Hensch N, Clavien PA, Jochum W, Soltermann A, Moch H, Kristiansen G: Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas. Histopathology; 2010 Apr;56(5):600-6
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  • [Title] Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas.
  • AIMS: To study the relevance of periostin, known to be involved in epithelial-mesenchymal transition (EMT), in hepatocellular and bile duct cancer.
  • METHODS AND RESULTS: Immunohistochemical periostin expression was semiquantitatively analysed in normal liver tissue (n = 20), hepatocellular carcinoma (HCC; n = 91), liver-cell adenoma (n = 9), focal nodular hyperplasia (n = 13) and bile duct carcinomas (BDC; n = 116) using tissue microarrays.
  • Epithelial expression in tumour cells was significantly associated with a higher tumour grade (P < 0.05) and hepatitis B virus infection (P = 0.007).
  • Importantly, there was no strong periostin expression in benign liver tumours.
  • Epithelial periostin expression was associated with reduced overall survival on univariate and multivariate analysis.
  • CONCLUSIONS: The EMT protein periostin is expressed in the stroma and epithelium of a subset of BDC and HCC.
  • [MeSH-major] Adenoma / metabolism. Bile Duct Neoplasms / metabolism. Carcinoma, Hepatocellular / metabolism. Cell Adhesion Molecules / metabolism. Focal Nodular Hyperplasia / metabolism. Liver Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Hepatectomy. Humans. Immunohistochemistry. Liver / metabolism. Liver / pathology. Male. Middle Aged. Prognosis. Survival Rate. Switzerland / epidemiology. Tissue Array Analysis. Young Adult

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  • (PMID = 20459570.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / POSTN protein, human
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72. Hur M, Yeo I, Park E, Kim YH, Yoo J, Kim E, No MH, Koh J, Kim S: Combination of statistical methods and Fourier transform ion cyclotron resonance mass spectrometry for more comprehensive, molecular-level interpretations of petroleum samples. Anal Chem; 2010 Jan 1;82(1):211-8
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  • Complex petroleum mass spectra obtained by Fourier-transform ion cyclotron resonance mass spectrometry (FTICR MS) were successfully interpreted at the molecular level by applying principle component analysis (PCA) and hierarchical clustering analysis (HCA).
  • Conventional data analyses would have been impractical with so much data.
  • HCA was also performed to group and compare samples based on selected peaks that had been grouped by PCA.
  • Subsequent heat map analyses revealed detailed compositional differences among grouped samples.
  • [MeSH-major] Cyclotrons. Fourier Analysis. Mass Spectrometry / methods. Petroleum / analysis

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  • (PMID = 19968292.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Petroleum
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73. Hillebrecht A, Klebe G: Use of 3D QSAR models for database screening: a feasibility study. J Chem Inf Model; 2008 Feb;48(2):384-96
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  • As model system isozymes of human carbonic anhydrase (hCA) are used, all results are exemplified studying affinity toward hCA II and selectivity between hCA I and II.

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  • (PMID = 18211050.001).
  • [ISSN] 1549-9596
  • [Journal-full-title] Journal of chemical information and modeling
  • [ISO-abbreviation] J Chem Inf Model
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II
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74. Kang JS, Wanibuchi H, Morimura K, Gonzalez FJ, Fukushima S: Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo. Cancer Res; 2007 Dec 1;67(23):11141-6
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  • Liver weights of Cyp2e1-null mice were significantly different at weeks 24 and 36 compared with wild-type mice (P < 0.01).
  • Liver tumor incidences of Cyp2e1-null mice were significantly decreased at weeks 24 and 36 compared with wild-type mice (P < 0.01).
  • Cyp2e1-null mice showed significant decrease in the multiplicities of hepatocellular adenoma at weeks 24 and 36 (P < 0.05 and P < 0.01, respectively), and of hepatocellular carcinoma at week 36 (P < 0.01) compared with wild-type mice.
  • [MeSH-major] Carcinogens / toxicity. Carcinoma, Hepatocellular / enzymology. Cytochrome P-450 CYP2E1 / physiology. Diethylnitrosamine / toxicity. Liver Neoplasms, Experimental / enzymology

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  • (PMID = 18056438.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / RNA, Messenger; 0 / bcl-2-Associated X Protein; 3IQ78TTX1A / Diethylnitrosamine; EC 1.14.13.- / Cytochrome P-450 CYP2E1; EC 3.4.22.- / Caspase 3
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75. Kaakinen T, Alaoja H, Heikkinen J, Dahlbacka S, Laurila P, Kiviluoma K, Salomäki T, Tuominen H, Ohtonen P, Biancari F, Juvonen T: Hypertonic saline dextran improves outcome after hypothermic circulatory arrest: a study in a surviving porcine model. Ann Thorac Surg; 2006 Jan;81(1):183-90
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  • [Title] Hypertonic saline dextran improves outcome after hypothermic circulatory arrest: a study in a surviving porcine model.
  • In the present study we have assessed its potential neuroprotective efficacy in the setting of hypothermic circulatory arrest in a surviving porcine model.
  • METHODS: Twenty-four pigs were randomized to receive two 5-minute intravenous infusions (4 mL/kg) of either HSD (7.5 % saline, 6% dextran 70) or normal saline immediately after and 4 hours after a 75-minute period of hypothermic circulatory arrest at a brain temperature of 18 degrees C.
  • Intracranial pressure was lower in the HSD group from 45 minutes to 8 hours after hypothermic circulatory arrest (p = 0.03).
  • Cerebral perfusion pressure was higher in the HSD group from 45 minutes to 3 hours after hypothermic circulatory arrest (p = 0.06).
  • CONCLUSIONS: The use of HSD in experimental hypothermic circulatory arrest is associated with significantly better neurologic recovery, better histopathology, lower intracranial pressure, higher cerebral perfusion pressure, and better preservation of brain metabolism.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Dextrans / therapeutic use. Hypoxia-Ischemia, Brain / etiology. Neuroprotective Agents / therapeutic use. Reperfusion Injury / prevention & control. Saline Solution, Hypertonic / therapeutic use. Sodium Chloride / therapeutic use
  • [MeSH-minor] Animals. Behavior, Animal / drug effects. Body Temperature. Brain / pathology. Brain Chemistry. Cardiopulmonary Bypass / adverse effects. Drug Administration Schedule. Drug Evaluation, Preclinical. Female. Glucose / analysis. Infusions, Intravenous. Intracranial Pressure / drug effects. Lactates / analysis. Oxygen / analysis. Partial Pressure. Pyruvates / analysis. Random Allocation. Sus scrofa

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  • [CommentIn] Ann Thorac Surg. 2006 Jan;81(1):190 [16368361.001]
  • (PMID = 16368360.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Lactates; 0 / Neuroprotective Agents; 0 / Pyruvates; 0 / Saline Solution, Hypertonic; 0 / hypertonic saline-dextran solution; 451W47IQ8X / Sodium Chloride; IY9XDZ35W2 / Glucose; K3R6ZDH4DU / Dextrans; S88TT14065 / Oxygen
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76. Liu ZG, Sun LZ, Chang Q, Zhu JM, Dong C, Yu CT, Liu YM, Zhang HT: Should the "elephant trunk" be skeletonized? Total arch replacement combined with stented elephant trunk implantation for Stanford type A aortic dissection. J Thorac Cardiovasc Surg; 2006 Jan;131(1):107-13
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  • The stented graft, a 10-cm-long woven Dacron graft with a self-expandable stent, was implanted through the aortic arch during hypothermic circulatory arrest.
  • RESULTS: Cardiopulmonary bypass time was 166 +/- 38 minutes, and average selective cerebral perfusion and lower body arrest time was 30 +/- 15 minutes.
  • [MeSH-minor] Acute Disease. Adult. Aged. Cardiopulmonary Bypass. Chronic Disease. Female. Humans. Male. Middle Aged. Vascular Surgical Procedures / methods

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  • (PMID = 16399301.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Rubio CA: Possible mechanism connected with the progression of submucosal invasion in colorectal neoplasias. Anticancer Res; 2005 May-Jun;25(3c):2503-7
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  • In this work, the characteristics of the glands at the growing edge in adenomas with submucosal invasion were investigated in 56 patients.
  • Sections (stained with hematoxylin-eosin, and MNF 116) from 56 colonic adenomas with submucosal invasion were reviewed.
  • Pore formation was defined as a glandular defect characterised by lack of a group of epithelial cells in the deeper portion of the glands.
  • Through those pores retained mucin, neutophils and/or necrotic material, containing proteolytic enzymes, were siphoned off into the surrounding tissues, causing disruption of the paratumoral ECM and facilitating host penetration by neoplastic cells.
  • Glandular continuity seems to be restored by the proliferation of malignant cells from the tip of the free borders of the pores into the disrupted ECM.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Disease Progression. Eosine Yellowish-(YS). Hematoxylin. Humans. Intestinal Mucosa / pathology. Neoplasm Invasiveness

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  • (PMID = 16080484.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
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78. Boyault S, Rickman DS, de Reyniès A, Balabaud C, Rebouissou S, Jeannot E, Hérault A, Saric J, Belghiti J, Franco D, Bioulac-Sage P, Laurent-Puig P, Zucman-Rossi J: Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology; 2007 Jan;45(1):42-52
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  • Hepatocellular carcinomas (HCCs) are a heterogeneous group of tumors that differ in risk factors and genetic alterations.
  • Global transcriptome analyses were performed on 57 HCCs and 3 hepatocellular adenomas and validated by quantitative RT-PCR using 63 additional HCCs.
  • Unsupervised transcriptome analysis identified 6 robust subgroups of HCC (G1-G6) associated with clinical and genetic characteristics.
  • G1 tumors were associated with low copy number of HBV and overexpression of genes expressed in fetal liver and controlled by parental imprinting.
  • G3 tumors were typified by mutation of TP53 and overexpression of genes controlling the cell cycle.
  • G4 was a heterogeneous subgroup of tumors including TCF1-mutated hepatocellular adenomas and carcinomas.
  • [MeSH-major] Carcinoma, Hepatocellular / classification. Carcinoma, Hepatocellular / genetics. Genes, Neoplasm. Liver Neoplasms / classification. Liver Neoplasms / genetics. Transcription, Genetic
  • [MeSH-minor] Adenoma / classification. Adenoma / drug therapy. Adenoma / genetics. Adenoma / metabolism. Cell Cycle Proteins / genetics. Cell Cycle Proteins / metabolism. DNA, Neoplasm / genetics. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Multigene Family. Mutation / genetics. Nuclear Pore Complex Proteins / genetics. Nuclear Pore Complex Proteins / metabolism. Phosphatidylinositol 3-Kinases / genetics. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / genetics. Proto-Oncogene Proteins c-akt / metabolism. Signal Transduction / genetics. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism. Wnt Proteins / genetics. Wnt Proteins / metabolism


79. Pele LC, Thoree V, Mustafa F, He S, Tsaprouni L, Punchard NA, Thompson RP, Evans SM, Powell JJ: Low dietary calcium levels modulate mucosal caspase expression and increase disease activity in mice with dextran sulfate sodium induced colitis. J Nutr; 2007 Nov;137(11):2475-80
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  • [Title] Low dietary calcium levels modulate mucosal caspase expression and increase disease activity in mice with dextran sulfate sodium induced colitis.
  • BALB/c mice received a normal Ca (NCa) diet (0.5% Ca), a high Ca (HCa) diet (1.5% Ca), a low Ca (LCa) diet (0.05% Ca), or a very low Ca (VLCa) diet (0.009% Ca) for 3 wk.
  • Half of the mice in each group received DSS (1.5%) for 20 d in their drinking water, and disease activity was assessed.
  • DSS-induced disease activity was higher in mice fed low dietary Ca levels [P < 0.0001, VLCa and DSS vs. NCa and DSS (NCaDSS) and P < 0.005, LCa and DSS vs. NCaDSS], and mice from the VLCa group were moribund within 11 d of DSS administration.
  • Those in the HCa group did not differ greatly from controls.
  • [MeSH-minor] Animals. Dextran Sulfate. Disease Models, Animal. Female. Inflammation. Mice. Mice, Inbred BALB C

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  • (PMID = 17951488.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U105960399
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium, Dietary; 9042-14-2 / Dextran Sulfate; EC 3.4.22.- / Caspases; SY7Q814VUP / Calcium
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80. Pérez Arroyuelos I, Alvarez Francisco R, Lázaro Serrano M: [Case images: 2. Hemorrhagic hepatic adenoma]. Radiologia; 2006 Nov-Dec;48(6):384, 405
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  • [Title] [Case images: 2. Hemorrhagic hepatic adenoma].
  • [Transliterated title] Casos en imagen: 2. Adenoma hepático hemorrágico.
  • [MeSH-major] Adenoma / diagnostic imaging. Hemoperitoneum / diagnostic imaging. Liver Neoplasms / diagnostic imaging. Radiography, Abdominal
  • [MeSH-minor] Adult. Diagnosis, Differential. Embolization, Therapeutic. Female. Humans. Ultrasonography

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  • (PMID = 17323896.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiologia
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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81. Abdo MR, Vullo D, Saada MC, Montero JL, Scozzafava A, Winum JY, Supuran CT: Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives. Bioorg Med Chem Lett; 2009 May 1;19(9):2440-3
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  • The compounds showed a weak hCA I activation profile, but were more efficient as hCA II and IX activators.
  • The 4-iodophenyl-substituted derivative behaved as a strong and isozyme selective hCA II activator, with an activation constant of 0.21muM.

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  • (PMID = 19345095.001).
  • [ISSN] 1464-3405
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Protein Isoforms; 0 / Recombinant Proteins; 0 / phenylsulfonylhydrazido l-histidine; 4QD397987E / Histidine; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
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82. van den Esschert JW, van Gulik TM, Phoa SS: Imaging modalities for focal nodular hyperplasia and hepatocellular adenoma. Dig Surg; 2010;27(1):46-55
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  • [Title] Imaging modalities for focal nodular hyperplasia and hepatocellular adenoma.
  • BACKGROUND/AIMS: There are several imaging modalities available for the detection of focal liver lesions.
  • Differentiation between focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) is important because of the consequences for management.
  • METHODS: We reviewed the literature for typical features of FNH and HCA on radiologic and nuclear imaging with emphasis on differentiation of both lesions.
  • RESULTS: Seven articles describe the performance of an imaging modality for the differentiation between FNH and HCA.
  • Limitations of these studies are the small sample size and/or the lack of comparison with the 'gold standard', i.e. histological diagnosis.
  • No studies are available that compare the accuracy of several imaging modalities in the differentiation of FNH and HCA.
  • On contrast-enhanced US, the arterial filling direction of FNH is centrifugal and centripetal in case of HCA.
  • The parenchymal enhancement of FNH is sustained in the portal venous and delayed phases, but shows rapid washout in case of HCA.
  • Multiphase CT scan can differentiate FNH from HCA when there is a central scar.
  • On MRI with hepatocyte-specific contrast agents, HCA does not show contrast uptake in the hepatobiliary phase in contrast to FNH.
  • CONCLUSION: We conclude that there is limited evidence of the diagnostic performance of currently used imaging modalities for the differentiation of FNH and HCA.
  • We therefore propose a prospective study (DiFA trial) to determine the accuracy of several radiologic and nuclear imaging studies in differentiating FNH and HCA.
  • [MeSH-major] Adenoma, Liver Cell / diagnosis. Focal Nodular Hyperplasia / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Tomography, Spiral Computed

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20357451.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 68
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83. Sinha R, Peters U, Cross AJ, Kulldorff M, Weissfeld JL, Pinsky PF, Rothman N, Hayes RB: Meat, meat cooking methods and preservation, and risk for colorectal adenoma. Cancer Res; 2005 Sep 1;65(17):8034-41
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  • [Title] Meat, meat cooking methods and preservation, and risk for colorectal adenoma.
  • Cooking meat at high temperatures produces heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs).
  • Meat intake may increase cancer risk as HCAs, PAHs, and N-nitroso compounds are carcinogenic in animal models.
  • We investigated meat, processed meat, HCAs, and the PAH benzo(a)pyrene and the risk of colorectal adenoma in 3,696 left-sided (descending and sigmoid colon and rectum) adenoma cases and 34,817 endoscopy-negative controls.
  • The questionnaire was linked to a previously developed database to determine exposure to HCAs and PAHs.
  • Intake of red meat, with known doneness/cooking methods, was associated with an increased risk of adenoma in the descending and sigmoid colon [odds ratio (OR), 1.26; 95% confidence interval (95% CI), 1.05-1.50 comparing extreme quintiles of intake] but not rectal adenoma.
  • Well-done red meat was associated with increased risk of colorectal adenoma (OR, 1.21; 95% CI, 1.06-1.37).
  • Increased risks for adenoma of the descending colon and sigmoid colon were observed for the two HCAs: 2-amino-3,8-dimethylimidazo[4,5]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5]pyridine (OR, 1.18; 95% CI, 1.01-1.38 and OR, 1.17, 95% CI, 1.01-1.35, respectively) as well as benzo(a)pyrene (OR, 1.18; 95% CI, 1.02-1.35).
  • Greater intake of bacon and sausage was associated with increased colorectal adenoma risk (OR, 1.14; 95% CI, 1.00-1.30); however, total intake of processed meat was not (OR, 1.04; 95% CI, 0.90-1.19).
  • Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma.
  • [MeSH-major] Adenoma / etiology. Colorectal Neoplasms / etiology. Cooking. Food Preservation. Meat

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  • (PMID = 16140978.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Imidazoles; 0 / Mutagens; 0 / Quinoxalines; 3417WMA06D / Benzo(a)pyrene; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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84. Osborne-Bossert C, Fitzgerald D, Speir A, St Onge J: Delivery of antegrade cerebral perfusion during descending aortic reconstruction: a case report. Perfusion; 2008 Mar;23(2):135-7
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  • Antegrade cerebral perfusion (ACP) has been demonstrated to be a safe and effective method of providing adequate protection to the brain during hypothermic circulatory arrest.
  • By improving oxygen delivery to the cerebral capillaries, users of this technique have reported fewer temporary neurological deficits in postoperative periods, even after prolonged periods of circulatory arrest.
  • Surgical correction of a descending aortic aneurysm can provide a challenge when the left subclavian artery is involved.
  • A period of hypothermic circulatory arrest is required to complete the proximal anastamosis of the graft.
  • A 54-year-old female presented with a computerized tomography (CT) scan of a descending aortic aneurysm, originating at the base of the left subclavian artery.

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  • (PMID = 18840584.001).
  • [ISSN] 0267-6591
  • [Journal-full-title] Perfusion
  • [ISO-abbreviation] Perfusion
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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85. Apostolakis EE, Baikoussis NG, Katsanos K, Karanikolas M: Postoperative peri-axillary seroma following axillary artery cannulation for surgical treatment of acute type A aortic dissection. J Cardiothorac Surg; 2010;5:43
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  • Right axillary artery cannulation confers significant advantages, because it provides antegrade arterial perfusion during cardiopulmonary bypass, and allows continuous antegrade cerebral perfusion during hypothermic circulatory arrest, thereby minimizing global cerebral ischemia.
  • We herein present the case of a 36-year-old Caucasian man with known Marfan syndrome and acute type A aortic dissection, who had direct right axillary artery cannulation for surgery of the ascending aorta.

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  • [Cites] J Vasc Surg. 1999 Dec;30(6):1077-83 [10587392.001]
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  • (PMID = 20500837.001).
  • [ISSN] 1749-8090
  • [Journal-full-title] Journal of cardiothoracic surgery
  • [ISO-abbreviation] J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2880968
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86. Kouchoukos NT, Masetti P, Mauney MC, Murphy MC, Castner CF: One-stage repair of extensive chronic aortic dissection using the arch-first technique and bilateral anterior thoracotomy. Ann Thorac Surg; 2008 Nov;86(5):1502-9
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  • METHODS: Fifty-one patients with chronic expanding thoracic aortic dissections (48 type A, 3 type B with proximal extension) were treated with a single procedure using a bilateral anterior thoracotomy, hypothermic circulatory arrest, and reperfusion of the arch vessels first to minimize brain ischemia.
  • Forty-six patients had previous operations: for acute type A aortic dissection (n = 36), aortic valve disease (n = 6), or coronary artery disease (n = 4).
  • CONCLUSIONS: The technique is a safe and suitable alternative to the two-stage (elephant trunk technique) and hybrid procedures for treatment of chronic dissection with aneurysm of the thoracic aorta.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chronic Disease. Humans. Middle Aged. Recurrence. Reoperation. Survival Rate

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  • [CommentIn] Ann Thorac Surg. 2008 Nov;86(5):1509 [19049740.001]
  • (PMID = 19049739.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
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87. Ambrosi DJ, Tanasijevic B, Kaur A, Obergfell C, O'Neill RJ, Krueger W, Rasmussen TP: Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells. Stem Cells; 2007 May;25(5):1104-13
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  • [Title] Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells.
  • The resulting hybrids are pluripotent as judged by developmental assays, but detailed analyses of the underlying molecular-genetic control of reprogrammed transcription in such hybrids are required to better understand fusion-mediated reprogramming.
  • Comprehensive analysis of the mouse embryonic fibroblast/ESC hybrid transcriptome revealed global patterns of gene expression reminiscent of ESCs.
  • However, combined analysis of variance and hierarchical clustering analyses revealed at least seven distinct classes of differentially regulated genes in comparisons of hybrids, ESCs, and somatic cells.
  • Somatic/ESC hybrid cell lines resemble their pre-fusion ESC partners in terms of behavior in culture and pluripotency.
  • [MeSH-major] Cellular Reprogramming / genetics. Chimera / genetics. Embryonic Stem Cells / metabolism. Genome
  • [MeSH-minor] Alleles. Animals. Base Sequence. Cell Line. Chromosomes, Mammalian / genetics. Cluster Analysis. DNA Mutational Analysis. Gene Expression Profiling. Gene Expression Regulation, Developmental. Karyotyping. Mice. Molecular Sequence Data. Pluripotent Stem Cells / metabolism. Transcription, Genetic

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  • (PMID = 17272499.001).
  • [ISSN] 1066-5099
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01AG23687
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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88. Baraki H, Hagl C, Khaladj N, Kallenbach K, Weidemann J, Haverich A, Karck M: The frozen elephant trunk technique for treatment of thoracic aortic aneurysms. Ann Thorac Surg; 2007 Feb;83(2):S819-23; discussion S824-31
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  • BACKGROUND: The frozen elephant trunk technique allows for single-stage repair of combined aortic arch and descending aortic aneurysms using a hybrid prosthesis with a stented and a nonstented end.
  • The stented end of the hybrid prosthesis was placed through the opened aortic arch under fluoroscopic control using hypothermic circulatory arrest and selective antegrade cerebral perfusion.
  • In 1 patient, the descending aorta was perforated owing to misplacement of the stented end of the hybrid prosthesis.

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  • (PMID = 17257934.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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89. Horiuchi S, Kumai R, Tokunaga Y, Tokura Y: Proton dynamics and room-temperature ferroelectricity in anilate salts with a proton sponge. J Am Chem Soc; 2008 Oct 8;130(40):13382-91
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  • Dielectric measurements revealed phase transitions at T(c) = 334 and 172 K for bromanilate (Hba(-)) and chloranilate (Hca(-)) salts, respectively.

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  • (PMID = 18781747.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Xie C, Mace J, Dinno MA, Li YQ, Tang W, Newton RJ, Gemperline PJ: Identification of single bacterial cells in aqueous solution using confocal laser tweezers Raman spectroscopy. Anal Chem; 2005 Jul 15;77(14):4390-7
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  • [Title] Identification of single bacterial cells in aqueous solution using confocal laser tweezers Raman spectroscopy.
  • We report on a rapid method for reagentless identification and discrimination of single bacterial cells in aqueous solutions using a combination of laser tweezers and confocal Raman spectroscopy (LTRS).
  • The optical trapping enables capturing of individual bacteria in aqueous solution in the focus of the laser beam and levitating the captured cell well off the cover plate, thus maximizing the excitation and collection of Raman scattering from the cell and minimizing the unwanted background from the cover plate and environment.
  • Raman spectral patterns excited by a near-infrared laser beam provide intrinsic molecular information for reagentless analysis of the optically isolated bacterium.
  • We show that synchronized bacterial cells can be well-discriminated among the six species using principal component analyses (PCA).
  • Unsynchronized bacterial cells that are cultured at stationary phases can also be well-discriminated by the PCA, as well as by a hierarchical cluster analysis (HCA) of their Raman spectra.
  • We also show that unsynchronized bacteria selected from random growth phases can be classified with the help of a generalized discriminant analysis (GDA).
  • These findings demonstrate that the LTRS may find valuable applications in rapid sensing of microbial cells in diverse aqueous media.
  • [MeSH-major] Bacteria / cytology. Optical Tweezers. Spectrum Analysis, Raman / instrumentation. Spectrum Analysis, Raman / methods

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  • (PMID = 16013851.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Solutions
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91. Puccetti L, Fasolis G, Cecchi A, Winum JY, Gamberi A, Montero JL, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Bioorg Med Chem Lett; 2005 May 2;15(9):2359-64
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  • A series of such aromatic sulfonamides incorporating thioureido-sulfanilyl moieties has been prepared and investigated for its interaction with the catalytic domain of the human isozyme hCA IX.
  • Due to the highest expression of CA IX in clear renal cell carcinoma and its chemo/radioresistance, our efforts are first of all directed to generate effective therapeutic strategies for the cure of this malignancy.

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  • (PMID = 15837325.001).
  • [ISSN] 0960-894X
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carbonic Anhydrase Inhibitors; 0 / Sulfonamides; 8W8T17847W / Urea; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
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92. Trainer PJ: ACROSTUDY: the first 5 years. Eur J Endocrinol; 2009 Nov;161 Suppl 1:S19-24
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  • The AEs most frequently attributed to pegvisomant were disturbed liver function tests and injection site reactions.

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  • (PMID = 19684052.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Blood Glucose; 0 / Hemoglobin A, Glycosylated; 0 / Hormone Antagonists; 0 / Receptors, Somatotropin; 0 / pegvisomant; 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase
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93. Réti A, Barna G, Pap E, Adleff V, L Komlósi V, Jeney A, Kralovánszky J, Budai B: Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells. Pathol Oncol Res; 2009 Sep;15(3):335-44
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  • [Title] Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells.
  • The antiproliferative effect of 5-fluorouracil (5-FU) in the presence of low dose non-steroidal anti-inflammatory drugs (NSAIDs) on high cyclooxygenase-2 (COX-2)-expressing HCA-7 and low COX-2-expressing HT-29 colon carcinoma cell lines was investigated.
  • Pharmacogenetic parameters were studied to characterize the 5-FU sensitivity of the two cell lines.
  • Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms were determined by PCR analysis.
  • Cell proliferation was measured by SRB assay, cell cycle distribution and apoptosis by FACS analysis.
  • The HT-29 cell line was found to be homozygous for TS 2R and 1494ins6 and T homozygous for MTHFR 677 polymorphisms predicting high 5-FU sensitivity (IC(50): 10 microM).
  • TS 3R homozygosity, TS 1496del6 and MTHFR 677CT heterozygosity may explain the modest 5-FU sensitivity (IC(50): 1.1 mM) of the HCA-7 cell line.
  • Indomethacin and NS-398 (10 microM and 1.77 microM, respectively) reduced the PGE(2) level in HCA-7 cells (>90%).
  • Low concentrations of NSAIDs without antiproliferative potency increased the S-phase arrest and enhanced the cytotoxic action of 5-FU only in HCA-7 cells after 48-hours treatment.
  • The presented data suggested that the enhancement of 5-FU cytotoxicity by indomethacin or NS-398 applied in low dose is related to the potency of NSAIDs to modulate the cell-cycle distribution and the apoptosis; however, it seems that this effect might be dependent on cell phenotype, namely on the COX-2 expression.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Cell Proliferation / drug effects. Cyclooxygenase 2 / metabolism. Cyclooxygenase Inhibitors / pharmacology. Fluorouracil / pharmacology
  • [MeSH-minor] Apoptosis / drug effects. Blotting, Western. Cell Line, Tumor. Cell Separation. Enzyme-Linked Immunosorbent Assay. Flow Cytometry. HT29 Cells. Humans. Indomethacin / pharmacology. Methylenetetrahydrofolate Dehydrogenase (NADP) / genetics. Microscopy, Fluorescence. Nitrobenzenes / pharmacology. Polymorphism, Genetic. Reverse Transcriptase Polymerase Chain Reaction. Sulfonamides / pharmacology. Thymidylate Synthase / genetics

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  • (PMID = 19048402.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cyclooxygenase Inhibitors; 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.5.1.5 / Methylenetetrahydrofolate Dehydrogenase (NADP); EC 2.1.1.45 / Thymidylate Synthase; U3P01618RT / Fluorouracil; XXE1CET956 / Indomethacin
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94. Liu J, Waalkes MP: Liver is a target of arsenic carcinogenesis. Toxicol Sci; 2008 Sep;105(1):24-32
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  • [Title] Liver is a target of arsenic carcinogenesis.
  • Inorganic arsenic is clearly a human carcinogen causing tumors of the skin, lung, urinary bladder, and possibly liver (IARC, 2004).
  • This forum reevaluates epidemiology studies, rodent studies together with in vitro models, and focuses on the liver as a target organ of arsenic toxicity and carcinogenesis.
  • Hepatocellular carcinoma and hepatic angiosarcoma, have been frequently associated with environmental or medicinal exposure to arsenicals.
  • Recent work in mice clearly shows that exposure to inorganic arsenic during gestation induces tumors, including hepatocellular adenoma and carcinoma, in offspring when they reach adulthood.
  • In rats, the methylated arsenicals, dimethylarsinic acid promotes diethylnitrosamine-initiated liver tumors, whereas trimethylarsine oxide induces liver adenomas.
  • Chronic exposure of rat liver epithelial cells to low concentrations of inorganic arsenic induces malignant transformation, producing aggressive, undifferentiated epithelial tumors when inoculated into the Nude mice.
  • Some of these mechanisms may be liver specific/selective.
  • Overall, accumulating evidence clearly indicates that the liver could be an important target of arsenic carcinogenesis.

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  • (PMID = 18566022.001).
  • [ISSN] 1096-0929
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens; N712M78A8G / Arsenic
  • [Number-of-references] 86
  • [Other-IDs] NLM/ PMC2734307
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95. Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, Chen X, Kay MA, Wang R, Bishop JM: Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A; 2007 Sep 11;104(37):14771-6
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  • [Title] Distinct pathways of genomic progression to benign and malignant tumors of the liver.
  • We used several of the genetic lesions commonly associated with human liver tumors to reconstruct genetic progression to hepatocellular carcinoma and adenoma in mouse models.
  • Hepatocellular carcinoma in both instances arose from cooperation between MET and constitutively active versions of beta-catenin.
  • In contrast, adenomas were produced by cooperation between MET and defective signaling through the transcription factor HNF1alpha.
  • Prompted by these findings, we uncovered a coincidence between activation of the protein-tyrosine kinase encoded by MET and activating mutations of beta-catenin in a subset of human hepatocellular carcinomas.
  • Inactivation of MET transgenes led to regression of hepatocellular carcinomas despite the persistence of activated beta-catenin.
  • These results offer insight into hepatic tumorigenesis, provide mouse models that should be useful in the further study of hepatic tumorigenesis and for preclinical testing, and identify a subset of human hepatocellular carcinomas that may be susceptible to combination therapy directed against Met and the Wnt signaling pathway.


96. Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT: Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors. J Med Chem; 2005 Dec 1;48(24):7860-6
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  • A lately discovered carbonic anhydrase (hCA, EC 4.2.1.1), the mitochondrial hCA VB, was cloned, expressed, and purified.
  • Kinetic parameters proved it to be 3.37 times more effective than hCA VA as a catalyst for the physiological reaction, with kcat = 9.5 x 10(5) s(-1) and kcat/K(M) = 9.8 x 10(7) M(-1) s(-1), being second only to hCA II among the 16 isoforms presently known in humans.
  • We investigated the inhibition of hCA VB with a library of sulfonamides/sulfamates, some of which are clinically used compounds.
  • Benzenesulfonamides were ineffective inhibitors, whereas derivatives bearing 4-amino, 4-hydrazino, 4-methyl, 4-carboxy moieties or halogenated sulfanilamides were more effective (Ki's of 1.56-4.3 microM).
  • Among the 10 clinically used compounds, acetazolamide, benzolamide, topiramate, and indisulam showed effective inhibitory activity (Ki's of 18-62 nM).
  • Three compounds showed better activity against hCA VB over hCA II, among which were sulpiride and ethoxzolamide, which were 2 times more effective inhibitors of the mitochondrial over the cytosolic isozyme. hCA VB is a druggable target and some of its inhibitors may lead to the development of novel antiobesity therapies.

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  • (PMID = 16302824.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; 0 / Sulfonamides; 0 / Sulfonic Acids; 9NFU33906Q / sulfamic acid; EC 4.2.1.- / Carbonic Anhydrase V
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97. Rubio CA: Apoptosis versus polemosis. Different mechanisms leading to non-necrotic cell death. Anticancer Res; 2006 Jan-Feb;26(1A):183-6
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  • [Title] Apoptosis versus polemosis. Different mechanisms leading to non-necrotic cell death.
  • Apoptosis is a physiological auto-suicidal, genetically-induced cell deletion process of senescent effete normal cells.
  • The auto-destruction-induced by a cascade of caspases--results in the breakdown of normal cells and the formation of apoptotic bodies.
  • Those bodies are rapidly phagocytized by macrophages and internalized by cells of the same type.
  • On the other hand, polemosis (from Greek polemos: war) is a more dynamic mechanism of cell destruction between two different cell systems.
  • Polemosis is focal, haphazardly distributed at the time of observation, probably erratic and influenced by the chemotactical attraction of committed lymphocytes by neoplastic cells.
  • In this work, the possible association between CD68-positive macrophages and intraepithelial polemotic bodies was investigated in sections from 50 colorectal adenomas.
  • Polemotic bodies were found in groups of dysplastic cells in 84% (n=42) of the 50 adenomas, but none of them showed an accumulation of CD68 macrophages around the polemotic bodies.
  • As polemotic bodies (autologous T-cells DNA) are not engulfed by macrophages it is hypothesized that the DNA of these bodies might be incorporated into the nuclei of dysplastic cells.
  • This would satisfy the avidity of the DNA of rapidly proliferating dysplastic cells, a process that takes place, unremittingly, at any given time.
  • [MeSH-major] Adenoma / pathology. Apoptosis / physiology. Cell Death / physiology. Colorectal Neoplasms / pathology

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  • (PMID = 16475696.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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98. Bioulac-Sage P, Laumonier H, Couchy G, Le Bail B, Sa Cunha A, Rullier A, Laurent C, Blanc JF, Cubel G, Trillaud H, Zucman-Rossi J, Balabaud C, Saric J: Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. Hepatology; 2009 Aug;50(2):481-9
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  • [Title] Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience.
  • We took advantage of the reported genotype/phenotype classification to analyze our surgical series of hepatocellular adenoma (HCA).
  • We identified 46 HNF1alpha-inactivated HCAs (44 women), 63 inflammatory HCAs (IHCA, 53 women) of which nine were also beta-catenin-activated, and seven beta-catenin-activated HCAs (all women); six additional cases had no known phenotypic marker and six others could not be phenotypically analyzed.
  • Twenty-three of 128 HCAs showed bleeding.
  • Steatosis (tumor), microadenomas (resected specimen), and additional benign nodules were more frequently observed in HNF1alpha-inactivated HCAs (P < 0.01) than in IHCAs.
  • Body mass index > 25, peliosis (tumor), and steatosis in background liver were more frequent in IHCA (P < 0.01).
  • After complete resection, new HCAs in the centimetric range were more frequently found during follow-up (>1 year) in HNF1alpha-inactivated HCA.
  • After incomplete resection (HCA left in nonresected liver), the majority of HCA remained stable in the two main groups and even sometimes regressed.
  • Six patients of 128 developed hepatocellular carcinoma (HCC) (all were beta-catenin-activated, whether inflammatory or not).
  • CONCLUSION: There were noticeable clinical differences between HNF1alpha-inactivated HCA and IHCA; there was no increased risk of bleeding or HCC related to the number of HCAs; beta-catenin-activated HCAs are at higher risk of HCC.
  • As a consequence, we believe that management of HCA needs to be adapted to the phenotype of these tumors.
  • [MeSH-major] Adenoma, Liver Cell / classification. Liver Neoplasms / classification

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  • (PMID = 19585623.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fatty Acid-Binding Proteins; 0 / Hepatocyte Nuclear Factor 1-alpha; 0 / Serum Amyloid A Protein; 0 / beta Catenin; 9007-41-4 / C-Reactive Protein
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99. Kakarla UK, Beres EJ, Ponce FA, Chang SW, Deshmukh VR, Bambakidis NC, Zabramski JM, Spetzler RF: Microsurgical treatment of pediatric intracranial aneurysms: long-term angiographic and clinical outcomes. Neurosurgery; 2010 Aug;67(2):237-49; discussion 250
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  • Rates of aneurysm recurrence and de novo formation were calculated.
  • Hypothermic circulatory arrest was used to treat 10 aneurysms (14%), all involving the basilar artery.
  • At angiographic follow-up (mean, 53 months; median, 32 months), the annual recurrence rate was 2.6%, and the annual rate of de novo formation or growth was 7.8%.
  • They leave higher rates of recurrence and de novo formation or growth than their adult counterparts, which mandates lifelong follow-up.

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  • (PMID = 20539250.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Della Porta MG, Malcovati L, Boveri E, Travaglino E, Pietra D, Pascutto C, Passamonti F, Invernizzi R, Castello A, Magrini U, Lazzarino M, Cazzola M: Clinical relevance of bone marrow fibrosis and CD34-positive cell clusters in primary myelodysplastic syndromes. J Clin Oncol; 2009 Feb 10;27(5):754-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical relevance of bone marrow fibrosis and CD34-positive cell clusters in primary myelodysplastic syndromes.
  • CD34+ cell clusters were found in 23% of patients and were associated with WHO categories with excess of blasts (P < .001) and poor-risk cytogenetics (P = .001).
  • In multivariable analysis, BM fibrosis and presence of CD34+ cell clusters had independent negative impact on overall survival (P < .001 and P = .019, respectively) and leukemia-free survival (P < .001 and P = .004, respectively).
  • A hierarchical clustering analysis identified three subsets of patients with distinct clinical features.
  • Furthermore, the presence of CD34+ cell clusters is an independent risk factor for progression to acute leukemia.
  • [MeSH-major] Antigens, CD34 / analysis. Bone Marrow / pathology. Myelodysplastic Syndromes / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Fibrosis. Humans. Leukemia, Myelomonocytic, Acute / pathology. Male. Middle Aged. Prognosis. Retrospective Studies






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