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1. Yaşar DG, Ozenirler S, Doğan M: A patient with primary biliary cirrhosis accompanied by Graves disease and Hurthle cell adenoma. Turk J Gastroenterol; 2007 Sep;18(3):198-200
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  • [Title] A patient with primary biliary cirrhosis accompanied by Graves disease and Hurthle cell adenoma.
  • A case of Hurthle cell adenoma and Graves disease associated with primary biliary cirrhosis is reported in a 51-year-old woman, who developed elevated liver enzymes and hyperthyroidism.
  • Thyroid disorders accompanying primary biliary cirrhosis, especially hypothyroidism, are well documented.
  • Moreover, there has been no previous report of a case with Hurthle cell adenoma accompanied by Graves disease and primary biliary cirrhosis.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Graves Disease / complications. Liver Cirrhosis, Biliary / complications. Thyroid Neoplasms / complications

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  • (PMID = 17891696.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Cholagogues and Choleretics; 724L30Y2QR / Ursodeoxycholic Acid
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2. Barnabei A, Ferretti E, Baldelli R, Procaccini A, Spriano G, Appetecchia M: Hurthle cell tumours of the thyroid. Personal experience and review of the literature. Acta Otorhinolaryngol Ital; 2009 Dec;29(6):305-11
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  • [Title] Hurthle cell tumours of the thyroid. Personal experience and review of the literature.
  • Hurthle cell carcinoma represents about 5% of differentiated thyroid carcinomas.
  • The prognosis of the malignant type of the tumour is still under debate as some Authors have reported that Hurthle cell adenoma occasionally behaves like Hurthle cell carcinoma.
  • Aim of the present study was to evaluate previously reported data and personal experience on the clinical and pathological features of patients affected by Hurthle cell tumour that may predict disease progression and death.
  • In the literature, factors potentially associated with decreased survival were identified and include: age, disease stage, tumour size, extra-glandular invasion, lymph node disease, distant metastases, extensive surgery, radioiodine treatment.
  • From 1992 to 2003, the Authors identified 28 patients affected by Hurthle cell tumour, 9 with Hurthle cell adenoma and 19 with Hurthle cell carcinoma.
  • Mean age of patients affected by adenoma was 49.7 years (range 30-72) vs. 49.3 years (range 15-72) in Hurthle cell carcinoma patients.
  • At histology, 9 adenomas, 5 "minimally invasive" and 14 invasive carcinomas were found.
  • Post-operatively, in Hurthle cell carcinoma patients, TNM staging showed 9 patients with stage I, 5 stage II, 4 stage III and one stage IVa (UICC, 2002).
  • One Hurthle cell carcinoma patient received external beam radiotherapy.
  • Relapse was not observed in any of the cases with adenoma.
  • Only one Hurthle cell carcinoma patient showed distant lung metastases at 60 months' follow-up.
  • In conclusion, Hurthle cell carcinoma was not found to present a more aggressive behaviour than follicular carcinoma, when risk factors, including extent of tumour invasion, were taken into account.
  • None of the patients with Hurthle cell adenoma showed a relapse or death caused by the tumour.
  • [MeSH-major] Thyroid Neoplasms

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  • (PMID = 20463834.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] Thyroid cancer, Hurthle cell
  • [Other-IDs] NLM/ PMC2868205
  • [Keywords] NOTNLM ; Hurthle cell adenoma / Hurthle cell carcinoma / Thyroid
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3. Pu RT, Yang J, Wasserman PG, Bhuiya T, Griffith KA, Michael CW: Does Hurthle cell lesion/neoplasm predict malignancy more than follicular lesion/neoplasm on thyroid fine-needle aspiration? Diagn Cytopathol; 2006 May;34(5):330-4
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  • [Title] Does Hurthle cell lesion/neoplasm predict malignancy more than follicular lesion/neoplasm on thyroid fine-needle aspiration?
  • Thyroid fine-needle aspiration (FNA) is a standard procedure for the clinical triage of thyroid nodules.
  • The diagnosis of an adequately sampled thyroid FNA is generally grouped into three categories: benign, malignant, and indeterminate.
  • The latter group usually includes follicular neoplasm, follicular lesion, and sometimes a more specific diagnosis such as Hurthle cell neoplasm or follicular lesion/neoplasm with Hurthle cell change.
  • Whether a FNA diagnosis of Hurthle cell lesion/neoplasm (HLN) denotes a worse clinical outcome than follicular lesion/neoplasm (FLN) remains controversial.
  • A cohort of 303 thyroid FNA cases with follow-up thyroidectomy in our institutes was identified, with the follow-up excision diagnosis compared to the FNA diagnosis in order to address this issue.
  • Upon excision, the FNA diagnosis of HLN group had 14 cases of goiter/nodular hyperplasia (16%), 46 cases of adenoma (12 follicular adenoma (14%) and 34 cases of Hurthle cell adenoma (39%)), and 27 cases of carcinoma (31%, 12 papillary carcinoma and 15 Hurthle cell carcinoma).
  • The FLN group had 74 cases of goiter/nodular hyperplasia (34.3%), 8 cases of Hashimoto thyroiditis (3.7%), 73 cases of follicular adenoma (33.8%), one case of granular cell tumor, and 60 cases of carcinoma (27.8%, 46 papillary carcinoma, 12 follicular carcinoma, and 1 Hurthle cell carcinoma and 1 parathyroid carcinoma) upon excision.
  • Hurthle cell carcinoma patients are typically older than patients with other cancer diagnoses (59 versus 44, P = 0.0077).
  • Males and older patients with a HLN FNA diagnosis carry a higher risk of Hurthle cell carcinoma upon thyroidectomy.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenoma / pathology. Adenoma, Oxyphilic / pathology. Biopsy, Fine-Needle / methods. Oxyphil Cells / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Cohort Studies. Female. Goiter, Nodular / pathology. Goiter, Nodular / surgery. Humans. Hyperplasia / pathology. Hyperplasia / surgery. Male. Middle Aged. Prognosis. Thyroid Nodule / pathology. Thyroid Nodule / surgery. Thyroidectomy

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  • (PMID = 16604553.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Villanueva Peña A, Roca Edreira A, De Diego Rodríguez E, Hernández Rodríguez R, Gutiérrez Baños JL, Aguilera Tubet C: [Bilateral multiple renal oncocytoma. Case report and review of the literature]. Prog Urol; 2007 Sep;17(5):997-9
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  • [Title] [Bilateral multiple renal oncocytoma. Case report and review of the literature].
  • [Transliterated title] Oncocytome rénal multiple bilatéral. Revue de la littérature a propos d'un cas.
  • The histological diagnosis was that of oxyphilic adenoma with an oncocytic appearance compatible with oncocytoma.
  • Although renal oncocytoma is relatively frequent, only 19 cases of bilateral multiple renal oncocytomas have been published in the world literature.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology

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  • (PMID = 17969806.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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5. Eiss D, Larousserie F, Mejean A, Ghouadni M, Merran S, Correas JM, Hélénon O: [Renal oncocytoma: CT diagnostic criteria revisited]. J Radiol; 2005 Dec;86(12 Pt 1):1773-82
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  • [Title] [Renal oncocytoma: CT diagnostic criteria revisited].
  • PURPOSE: To redefine and evaluate the computed tomographic criteria for the diagnosis of renal oncocytoma (RO) for which renal sparing surgery should be preferred.
  • A double blinded comparative study was made of 60 renal tumors (containing adenocarcinomas and oncocytomas) larger than 3 cm in diameter in order to evaluate the redefined CT diagnostic criteria.
  • RESULTS: Among RO larger than 3 cm in diameter, 55% presented a sharply defined low attenuation scar on post-contrast scans at the tubular nephrographic phase, central or eccentric, with homogeneous attenuation throughout the remainder of the hypervascular tumor which was classified in 3 different groups.
  • CONCLUSION: Our redefined computed tomographic criteria for the diagnosis of renal oncocytoma, eventually associated with renal biopsy, should increase the indications for renal sparing surgery for RO larger than 3 cm in diameter.
  • [MeSH-major] Adenoma, Oxyphilic / radiography. Kidney Diseases / radiography. Tomography, X-Ray Computed

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  • (PMID = 16333226.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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6. Vlachaki E, Tsapas A, Dimitrakopoulos K, Kontzoglou G, Klonizakis I: Parotid gland oncocytoma: a case report. Cases J; 2009;2:6423

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  • [Title] Parotid gland oncocytoma: a case report.
  • Oncocytomas are a rare group of neoplasms of the parotid gland which have been correlated to various viral infections.
  • We report the first case of a patient with parotid oncocytoma and a previous history of chronic HBV infection.

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  • (PMID = 20181155.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827107
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7. Monk IP, Lahiri R, Sivaprakasam R, Malhotra S, Praseedom RK, Jah A: Adrenocortical oncocytoma: Review of imaging and histopathological implications. Int J Surg Case Rep; 2010;1(3):30-2

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  • [Title] Adrenocortical oncocytoma: Review of imaging and histopathological implications.
  • Oncocytomas are rare tumours of the adrenal glands whose malignant potential is difficult to assess with certainty.
  • We report a case of an adrenal oncocytoma and present a review of the literature particularly with regards to the radiological and histopathological features and their impact on the management.Adrenal oncocytomas are usually identified incidentally on imaging and can achieve large sizes.

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  • (PMID = 22096671.001).
  • [ISSN] 2210-2612
  • [Journal-full-title] International journal of surgery case reports
  • [ISO-abbreviation] Int J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC3199705
  • [Keywords] NOTNLM ; Adrenal incidentaloma / Adrenal oncocytoma / Adrenal tumour / Adrenocortical oncocytoma
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8. Chao TC, Lin JD, Chen MF: Surgical treatment of Hurthle cell tumors of the thyroid. World J Surg; 2005 Feb;29(2):164-8
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  • [Title] Surgical treatment of Hurthle cell tumors of the thyroid.
  • Hurthle cell tumors are relatively rare thyroid tumors and their management and prognosis is controversial.
  • We retrospectively review 135 Hurthle cell adenomas and 28 Hurthle cell carcinomas of the thyroid surgically treated at our institute.
  • No significant difference was found between the adenoma and carcinoma groups in patient age, gender, and tumor size.
  • The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of frozen section in detecting malignancy of the thyroid gland were 40.0%, 100.0%, 92.9%, 100.0%, and 92.0%.
  • Most of the adenomas were treated with procedures no less invasive than lobectomy/isthmusectomy.
  • Meanwhile, most of the carcinoma patients underwent total thyroidectomy.
  • No recurrence of Hurthle cell adenomas was noted.
  • Five adenoma patients died of causes unrelated to their Hurthle cell tumors, but no carcinoma patients died during the follow-up period.
  • In conclusion, clinical factors and FNAC are not helpful in the differentiation between adenoma and carcinoma.
  • Unilateral Hurthle cell adenoma can be treated by lobectomy/isthmusectomy, and Hurthle cell carcinoma can be treated by total thyroidectomy with minimal operative morbidity.
  • [MeSH-major] Adenoma, Oxyphilic / surgery. Thyroid Neoplasms / surgery

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  • (PMID = 15650796.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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9. Ahmed M, Bin Yousef H, Greer W, Faraz H, Al Sobhi S, Al Zahrani A, Raef H, Al Ghamdi A, Al Kadhi Y, Al Dayel F: Hurthle cell neoplasm of the thyroid gland. ANZ J Surg; 2008 Mar;78(3):139-43
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  • [Title] Hurthle cell neoplasm of the thyroid gland.
  • BACKGROUND: A clinicopathological analysis and long-term follow up of 32 patients with Hurthle cell neoplasm (HCN) was undertaken to contrast the clinical and histological features between benign versus malignant HCN of thyroid and to examine the effect of treatment on the outcome.
  • METHODS: This is a retrospective study of 32 patients with HCN who were identified out of an archival clinical/pathological/imaging database of 3752 thyroid cancer patients seen between 1976 and June 2006.
  • All patients underwent thyroid surgery.
  • The mean tumour size was 4.43 +/- 0.66 cm for MHCN, and 2.57 +/- 0.32 cm for BHCN (P = 0.03).
  • Multicentric tumour foci were evident in five cases (29%) of MHCN but none among the BHCN (P = 0.03).
  • At neck exploration cervical lymph node dissection was carried out in nine MHCN patients with findings of tumour metastases in 33%.
  • Postoperatively, three MHCN patients had no thyroid remnant on ultrasound and computed tomography of neck and undetectable serum thyroglobulin; these were considered to be in remission.
  • Fourteen other MHCN patients with postoperative thyroid remnant and/or distant metastases received 131I treatment.
  • CONCLUSION: Features of MHCN consisted of a large tumour size, unequivocal capsular and vascular invasion, multicentric tumour foci, metastatic lymph node deposits in one-third of patients and presence of distant metastasis in a few.
  • Findings of dominant Hurthle cell cytology in a fine-needle aspiration biopsy from a thyroid nodule should prompt surgical resection of the lesion to assess malignancy.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / surgery. Neoplasm Recurrence, Local / pathology. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Registries. Retrospective Studies. Risk Assessment. Survival Analysis. Thyroidectomy / methods. Treatment Outcome

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  • [CommentIn] ANZ J Surg. 2008 Mar;78(3):115 [18269467.001]
  • (PMID = 18269475.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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10. Melck A, Bugis S, Baliski C, Irvine R, Anderson DW, Wilkins G, Zhang H, Wiseman SM: Hemithyroidectomy: the preferred initial surgical approach for management of Hurthle cell neoplasm. Am J Surg; 2006 May;191(5):593-7
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  • [Title] Hemithyroidectomy: the preferred initial surgical approach for management of Hurthle cell neoplasm.
  • BACKGROUND: The objective of this study was to evaluate the cancer risk of patient clinicopathologic characteristics to determine the optimal approach for the surgical management of individuals with Hurthle cell neoplasm (HN) diagnosed by cytology.
  • METHODS: Patient clinicopathologic characteristics evaluated included age, sex, tumor size, and ipsilateral thyroid lobe nodularity.
  • Although none of the clinicopathologic characteristics evaluated were able to reliably differentiate benign from malignant tumors, large tumor size and male sex were significantly associated with a pathologic diagnosis of Hurthle cell carcinoma (P < .05).
  • CONCLUSIONS: Hemithyroidectomy represents the preferred initial surgical approach for the management of individuals presenting with nodular thyroid disease and a cytologic diagnosis of HN.
  • [MeSH-major] Adenoma, Oxyphilic / surgery. Thyroid Neoplasms / surgery. Thyroidectomy / methods

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  • (PMID = 16647343.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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11. Imaizumi M, Nakatsuka K: Oncocytoma of the peripunctum. Int Ophthalmol; 2005 Jun;26(3):111-3
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  • [Title] Oncocytoma of the peripunctum.
  • BACKGROUND: Oncocytoma is rarely found around the lacrimal punctum.
  • We describe a case of oncocytoma of the peripunctum.
  • The tumor was completely excised including the lacrimal punctum and part of the canaliculus.
  • Histologically, the tumor had tubulo-papillary architecture and was composed of two layers of cuboidal cells.
  • The cytoplasm of the tumor cells was rich in eosinophilic granules.
  • The diagnosis was oncocytoma arising from the canaliculus.
  • CONCLUSION: Oncocytoma should be considered in differential diagnosis of a peripunctal mass in elderly patients.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus

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  • (PMID = 17091220.001).
  • [ISSN] 0165-5701
  • [Journal-full-title] International ophthalmology
  • [ISO-abbreviation] Int Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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12. Yen TH, Chen Y, Fu JF, Weng CH, Tian YC, Hung CC, Lin JL, Yang CW: Proliferation of myofibroblasts in the stroma of renal oncocytoma. Cell Prolif; 2010 Jun;43(3):287-96
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  • [Title] Proliferation of myofibroblasts in the stroma of renal oncocytoma.
  • OBJECTIVES: Myofibroblasts are a vital component of stroma of many malignant neoplasms, but it is not yet established whether stromal myofibroblasts also exist in benign tumours such as oncocytoma of the kidney.
  • MATERIALS AND METHODS: Histomorphological and immunohistochemical analysis of 16 renal oncocytomas diagnosed at Chang Gung Memorial Hospital, Taiwan, has been performed.
  • RESULTS: Renal oncocytomas were composed of oncocytes, large cells with granular eosinophilic cytoplasm, arranged mostly in sheets, in tubulocystic or combined pattern.
  • MIB-1 and active caspase 3 indices were low, but higher in tumour than in surrounding non-tumour parenchyma (MIB-1: 0.93 +/- 0.09 versus 0.46 +/- 0.07, P < 0.001 and active caspase 3: 0.76 +/- 0.08 versus 0.41 +/- 0.09, P < 0.001).
  • Wnt/beta-catenin signalling was not implicated in this neoplasm, as there was no loss of E-cadherin membranous localization or expression of intranuclear beta-catenin in the cells.
  • CONCLUSIONS: Renal oncocytomas were composed of two independent compartments: benign oncocytes and pronounced fibrotic stroma, which consisted of proliferating myofibroblasts (SMA- and MIB-1-positive) which were associated with excessive deposition of extracellular matrix (periodic acid Schiff-component, collagen I-, collagen III- and fibronectin-positive, and desmin- and human caldesmon-negative).
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Fibroblasts / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Proliferation. Extracellular Matrix / metabolism. Extracellular Matrix / pathology. Extracellular Matrix Proteins / metabolism. Female. Humans. Male. Middle Aged. Myoblasts / metabolism. Myoblasts / pathology. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 20412129.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Extracellular Matrix Proteins
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13. Francesca F, Pomara G, Campo G, Casale P: Elective open nephron-sparing surgery for renal masses: Single-center experience with 223 consecutive patients. J Clin Oncol; 2009 May 20;27(15_suppl):e16139

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  • The mean tumor size was 4.6 cm (1.1-12cm).
  • Renal cell carcinoma was present in 177 patients (76.6%), benign renal masses were diagnosed in in 54 pazienti (23.3%): angiomyolipoma (35%), oncocytoma (40%), complicated cyst (25%).
  • After a median follow-up of 84 months (range 5 to 120), no patient had developed local recurrence, 19 (8.9%) died for other causes, 2 (0.9%) died for other tumor.

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  • (PMID = 27963354.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Al-Shraim MM, Hussein MR, Musalam AO, Al-Ghandi T, Al-Zahramit H, Mahrouz AA, Abu-Eshy SA: Hurthle cell neoplasms of thyroid in south-western region of Saudi Arabia. West Afr J Med; 2010 Nov-Dec;29(6):398-402

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  • [Title] Hurthle cell neoplasms of thyroid in south-western region of Saudi Arabia.
  • BACKGROUND: Thyroid Hurthle cell neoplasm (THCN) is relatively rare.
  • METHODS: This was a retrospective chart review of all thyroid Hurthle cell neoplasms diagnosed at Aseer Central Hospital (ACH), Saudi Arabia during the period from October 1998 to April 2007.
  • Three cases were Hurthle cell carcinomas and six cases were Hurthle cell adenomas.
  • Adenomas presented as solitary nodules (two cases), as multinodular goiter (three cases) and as diffuse swelling (one case).
  • Fine needle aspiration cytology (FNAC) was diagnostic for THCN in two cases of carcinoma that presented as solitary nodules and hence total thyroidectomy was performed.
  • Total thyroidectomy was also done in one case of adenoma.
  • Hemithyroidectomy was performed in two cases of adenoma in which FNAC showed benign lesion and in one case of carcinoma based on clinical and ultrasonographic impression of benign MNG in the involved lobe and inconclusive FNAC result.
  • Subtotal thyroidectomy was performed in one case of adenoma.
  • Neither clinical nor FNAC findings can exclude carcinoma.
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Female. Humans. Male. Middle Aged. Retrospective Studies. Saudi Arabia. Thyroid Gland / pathology. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery. Thyroidectomy. Treatment Outcome. Young Adult

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  • (PMID = 21465448.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
  • [Chemical-registry-number] Thyroid cancer, Hurthle cell
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15. Ivey BS, Devarajan K, Sundaram CP: Bilateral oncocytoma and the value of needle biopsy. Can J Urol; 2010 Apr;17(2):5131-4
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  • [Title] Bilateral oncocytoma and the value of needle biopsy.
  • INTRODUCTION: Renal oncocytoma represents a diagnostic challenge to urologists.
  • We present three patients with bilateral renal oncocytomas.
  • CASES: All three patients presented with bilateral renal masses and through surgical means, were diagnosed with oncocytoma.
  • Renal biopsies were used to diagnose oncocytoma in the contralateral kidney.
  • DISCUSSION: Considering oncocytoma represents up to 16% of renal masses, there is overtreatment of benign disease due the difficulty in distinguishing between histologies on radiographs.
  • Even when the diagnosis of oncocytoma is made, concurrent renal cell carcinoma can be found in a small subset of patients.
  • CONCLUSIONS: Oncocytoma in the setting of bilateral renal masses presents a difficult clinical scenario.
  • The clinician must exclude renal cell carcinoma from the differential diagnosis.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Biopsy, Needle / methods. Kidney Neoplasms / pathology

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  • (PMID = 20398456.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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16. Pachón Sánchez D, Palou Redorta J, Rosales Bordes A, Navarro Genta M, Villavicencio Mavrich H: [Renal cell carcinoma associated with contralateral metacronous renal oncocytoma]. Arch Esp Urol; 2005 Mar;58(2):175-8
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  • [Title] [Renal cell carcinoma associated with contralateral metacronous renal oncocytoma].
  • [Transliterated title] Carcinoma de células renales asociado a oncocitoma renal contralateral metacrónico.
  • OBJECTIVES: To report one case of renal cell carcinoma and contralateral metacronous oncocytoma, and to perform a bibliographic review on the topic.
  • METHODS: 52-year-old male patient with history of right radical nephrectomy for renal cell carcinoma.
  • Pathological study showed three oncocytomas.
  • CONCLUSIONS: The presence of metacronous lesions in the contralateral kidney of a patient with history of renal cell carcinoma is rare.
  • The presence of the same histological type of tumor should always be suspected and the management should follow this suspicion.
  • Contralateral metacronous oncocytoma is a rare pathology which has not been reported in the literature so far.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis

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  • (PMID = 15847278.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 10
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17. Neuzillet Y, Lechevallier E, Andre M, Daniel L, Nahon O, Coulange C: Follow-up of renal oncocytoma diagnosed by percutaneous tumor biopsy. Urology; 2005 Dec;66(6):1181-5
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  • [Title] Follow-up of renal oncocytoma diagnosed by percutaneous tumor biopsy.
  • OBJECTIVES: To evaluate the outcome of patients with oncocytoma of the kidney diagnosed in our center by percutaneous biopsy and treated with watchful waiting.
  • METHODS: From January 1998 to April 2004, of 148 solid renal tumors biopsied in our center, 15 were renal oncocytomas.
  • RESULTS: The mean age at diagnosis was 57.6 +/- 14.4 years, and mean tumor size was 3.49 +/- 2.43 cm, corresponding to a mean tumor volume of 62.3 +/- 135.4 cm3.
  • Indications for surgery were initial tumor burden, greater than 0.5 cm/yr tumor growth, and patient's preference in 1 case, 4 cases, and 1 case, respectively.
  • The patients who received surgical treatment were significantly younger (45.5 +/- 11.1 years versus 65.6 +/- 10.3 years) and had more bulky tumors at diagnosis (50 +/- 30.1 mm versus 27.3 +/- 10.5 mm).
  • In 1 patient, a chromophobic renal cell carcinoma was associated with the oncocytoma.
  • CONCLUSIONS: The evolution of renal oncocytoma seems to be increase of tumor size with variable velocity.
  • Initial tumor volume or fast tumor growth are indications for surgery.
  • Partial nephrectomy, if the tumor size and localization are reasonable, is currently the technique of choice.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / therapy. Kidney Neoplasms / pathology. Kidney Neoplasms / therapy

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  • (PMID = 16360437.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Hes O, Michal M, Kuroda N, Martignoni G, Brunelli M, Lu Y, Adley BP, Alvarado-Cabrero I, Yang XJ: Vimentin reactivity in renal oncocytoma: immunohistochemical study of 234 cases. Arch Pathol Lab Med; 2007 Dec;131(12):1782-8
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  • [Title] Vimentin reactivity in renal oncocytoma: immunohistochemical study of 234 cases.
  • CONTEXT: The expression of vimentin in benign renal oncocytomas has been controversial.
  • However, this is of clinical significance because immunostains may be used in differential diagnosis of renal tumors on limited biopsy specimens.
  • Using different staining and analysis methods, we studied vimentin immunoreactivity in a large series of renal oncocytomas with a special emphasis on the immunoreactivity patterns.
  • OBJECTIVE: Immunohistochemical expression of vimentin has been used in the differential diagnosis of renal epithelial neoplasms.
  • Although typically expressed in most renal cell carcinomas, the immunoreactivity of this intermediate filament in renal oncocytomas has been controversial.
  • DESIGN: We studied vimentin immunoreactivity in a large series of 234 renal oncocytomas using 2 staining methods as well as manual and automated imaging analyses.
  • RESULTS: We found that the focal vimentin immunoreactivity can be seen in most (72.6%) renal oncocytomas with vimentin-positive tumor cells usually found in the edge of a central scar or in small clusters scattered throughout the tumor.
  • Computer-aided imaging analysis using ChromaVision Automatic Cellular Imaging System II confirmed the difference in vimentin immunoreactivity between oncocytoma and other renal neoplasms.
  • CONCLUSIONS: Our study of vimentin immunohistochemistry in a series of renal oncocytomas, which to our knowledge is the largest ever published, showed focal vimentin positivity detected in most oncocytomas.
  • Because the vimentin staining patterns in renal oncocytomas are different from those seen in clear cell or papillary renal cell carcinomas, we consider vimentin staining to be helpful in the differential diagnosis of oncocytoma from other renal tumor mimics.
  • Furthermore, strong vimentin positivity in a renal cell neoplasm does not exclude the diagnosis of renal oncocytoma, particularly in a limited biopsy specimen.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Kidney Neoplasms / metabolism. Vimentin / biosynthesis

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  • (PMID = 18081436.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vimentin
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19. Coburn V, Radfar A, Snook D, Mahalingam M: Cutaneous oncocytoma - a report of three cases and review of the literature. J Cutan Pathol; 2007 Apr;34(4):355-9
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  • [Title] Cutaneous oncocytoma - a report of three cases and review of the literature.
  • The oncocyte is a cell characterized by capacious, eosinophilic, finely granular cytoplasm, and lesions composed primarily of oncocytes are termed oncocytomas.
  • Whereas oncocytic metaplasia has been reported in various cutaneous neoplasms, oncocytomas typically occur in the kidneys, thyroid and salivary glands and are uncommon in the dermatopathology literature.
  • We present three cases of cutaneous oncocytoma so that dermatopathologists are cognizant of this uncommon entity.
  • Although some believe that oncocytomas are locally aggressive lesions, our cases indicate that their clinical course is perhaps as banal as their histology.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Epidermal Cyst / pathology. Female. Humans. Male. Middle Aged

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  • (PMID = 17381809.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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20. Okoń K, Sińczak-Kuta A: Nuclear morphometry as a tool of limited capacity for distinguishing renal oncocytoma from chromophobe carcinoma. Pol J Pathol; 2008;59(1):9-13
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  • [Title] Nuclear morphometry as a tool of limited capacity for distinguishing renal oncocytoma from chromophobe carcinoma.
  • The principal types of renal tumors include malignant clear cell renal cell carcinoma, chromophobe carcinoma (ChRCC), papillary carcinoma and benign oncocytoma (RO) and adenoma.
  • Both oncocytoma and chromophobe carcinoma are characterized by a solid growth pattern of cell with abundant cytoplasm and in some cases may be difficult to distinguish based on histology only.
  • The material for the study consisted of 58 chromophobe carcinomas and 16 oncocytomas.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Cell Nucleus / pathology. Kidney Neoplasms / diagnosis

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  • (PMID = 18655365.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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21. Kim JI, Cho JY, Moon KC, Lee HJ, Kim SH: Segmental enhancement inversion at biphasic multidetector CT: characteristic finding of small renal oncocytoma. Radiology; 2009 Aug;252(2):441-8
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  • [Title] Segmental enhancement inversion at biphasic multidetector CT: characteristic finding of small renal oncocytoma.
  • PURPOSE: To retrospectively determine the usefulness of segmental enhancement inversion during the corticomedullary phase (CMP) and early excretory phase (EEP) of biphasic multidetector computed tomography (CT) in differentiating small renal oncocytoma from renal cell carcinoma (RCC).
  • Between January 2004 and December 2006, 98 patients with pathologically confirmed renal masses smaller than 4 cm (10 renal oncocytomas and 88 RCCs) were included in this study.
  • The Fisher exact test was used to determine the significance of segmental enhancement inversion in differentiating small renal oncocytoma from RCC.
  • RESULTS: Eight of 10 renal oncocytomas and only one of 88 RCCs showed segmental inversion during CMP and EEP, which significantly differentiated small renal oncocytomas and RCCs (P < .0001).
  • For differentiating oncocytoma from RCC, segmental inversion was found to have a sensitivity of 80% (eight of 10), a specificity of 99% (87 of 88), a positive predictive value of 89% (eight of nine), and a negative predictive value of 98% (87 of 89).
  • CONCLUSION: Segmental enhancement inversion during CMP and EEP was found to be a characteristic enhancement pattern of small renal oncocytoma at biphasic multidetector CT and it may help in differentiating small oncocytoma from RCC.
  • [MeSH-major] Adenoma, Oxyphilic / radiography. Carcinoma, Renal Cell / radiography. Kidney Neoplasms / radiography. Radiographic Image Enhancement / methods. Radiographic Image Interpretation, Computer-Assisted / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19508984.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Yusenko MV: Molecular pathology of renal oncocytoma: a review. Int J Urol; 2010 Jul;17(7):602-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular pathology of renal oncocytoma: a review.
  • Differentiating renal oncocytoma from its renal cell carcinoma (RCC) mimics, particularly chromophobe RCC, can be difficult, especially when limited tissue is available for evaluation and requires sophisticated microscopic, ultrastructural and immunohistochemical evaluation.
  • In this review, the relevant literature has been reviewed, and supporting data obtained by applying modern microarray-based technologies are discussed with a focus on molecular pathology of renal oncocytoma.
  • Renal oncocytomas are characterized by variable chromosomal patterns.
  • The conflicting staining patterns, together with the poor specificity of proposed antibodies, leads us to believe that these candidate immunomarkers might not help in the separation of these tumors.
  • Applying DNA based tools might help in the diagnosis of renal oncocytoma with uncertain histology.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology

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  • [CommentIn] Int J Urol. 2010 Jul;17(7):612-3 [20590945.001]
  • [CommentIn] Int J Urol. 2010 Jul;17(7):613-4 [20590946.001]
  • [ErratumIn] Int J Urol. 2011 Aug;18(8):614
  • (PMID = 20590944.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
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23. Demirović A, Cesarec S, Spajić B, Tomas D, Bulimbasić S, Milosević M, Marusić Z, Kruslin B: Can renal oncocytoma be distinguished from chromophobe renal cell carcinoma by the presence of fibrous capsule? Virchows Arch; 2010 Jan;456(1):85-9
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  • [Title] Can renal oncocytoma be distinguished from chromophobe renal cell carcinoma by the presence of fibrous capsule?
  • The most important differential diagnosis of chromophobe renal cell carcinoma (CRCC) is renal oncocytoma.
  • Due to overlapping morphological characteristics of renal oncocytoma and CRCC, particularly its eosinophilic variant, making a correct diagnosis can be challenging.
  • To date, no data are available on the presence of the tumor fibrous capsule as a diagnostic feature in differentiating these tumors.
  • The main purpose of this study was to establish the presence and compare the thickness of the tumor fibrous capsule between two tumor groups.
  • A total of 37 tumors--18 cases of CRCC (three eosinophilic and 15 classic) and 19 cases of renal oncocytoma--were analyzed.
  • Four slides of each tumor stained with hematoxylin and eosin were first scanned at low-power magnification (x40) to assess the presence of the capsule.
  • The capsule was present in 12 (66.7%) cases of CRCCs and in only two (10.5%) cases of renal oncocytomas.
  • Statistical analysis showed significant difference between the presence of fibrous capsule in these two observed tumor groups (P = 0.001).
  • Average thickness of capsule in CRCCs was 337.7 microm, and 115.4 microm in renal oncocytomas, but the median was not statistically significant (P = 0.198).
  • Studies with a larger number of cases are needed to conclude if this characteristic could be a low-cost, reliable microscopic feature in differentiating between CRCC and renal oncocytoma.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology. Neoplasms, Glandular and Epithelial / diagnosis. Neoplasms, Glandular and Epithelial / pathology


24. Adley BP, Gupta A, Lin F, Luan C, Teh BT, Yang XJ: Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma. Am J Clin Pathol; 2006 Jul;126(1):79-85
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  • [Title] Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma.
  • Kidney-specific cadherin (Ksp-cad) recently was proposed to differentiate chromophobe renal cell carcinoma (RCC) from oncocytoma based on a finding of Ksp-cad expression in 97% of chromophobe RCCs but only 3% of oncocytomas.
  • However, another study showed no difference in Ksp-cad immunoreactivity between these 2 tumors.
  • We attempted to evaluate Ksp-cad expression in renal tumors using expression microarrays and immunohistochemical analysis.
  • Ksp-cad messenger RNA (mRNA) levels were examined in 158 renal tumors, including 15 chromophobe RCCs and 15 oncocytomas.
  • Immunohistochemical analysis was performed on tissue microarrays containing 125 renal tumors, including 36 chromophobe RCCs and 41 oncocytomas.
  • Ksp-cad mRNA compared with normal kidney tissue was 89% in chromophobe RCC and 64% in oncocytoma.
  • Furthermore, 31 of 36 chromophobe RCCs and 31 of 41 oncocytomas showed Ksp-cad immunoreactivity.
  • Ksp-cad was present in chromophobe RCCs and oncocytomas at mRNA and protein levels, providing strong evidence that Ksp-cad immunohistochemical analysis cannot be used in differentiating these tumors.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Cadherins / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Oligonucleotide Array Sequence Analysis. RNA, Messenger / metabolism. Retrospective Studies


25. Chen YT, Tu JJ, Kao J, Zhou XK, Mazumdar M: Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinoma. Clin Cancer Res; 2005 Sep 15;11(18):6558-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinoma.
  • PURPOSE: Morphologic distinction among clear cell, papillary, and chromophobe types of renal cell carcinoma (RCC) can be difficult, as is the differential diagnosis between oncocytoma and RCC.
  • Whether these renal tumors can be distinguished by their mRNA expression profile of a few selected genes was examined.
  • EXPERIMENTAL DESIGN: The expression of four genes in renal tumor was evaluated by quantitative reverse transcription-PCR: carbonic anhydrase IX (CA9), methylacyl-CoA racemase (AMACR), parvalbumin (PVALB), and chloride channel kb (CLCNKB).
  • Thirty-one fresh-frozen and 63 formalin-fixed, paraffin-embedded tumor specimens were analyzed.
  • RESULTS: CA9 expression was highest in clear cell carcinoma and lowest in chromophobe RCC and in oncocytoma.
  • AMACR expression was highest in papillary RCC, and CLCNKB was highest in chromophobe RCC/oncocytoma.
  • PVALB was highest in chromophobe RCC, variable in oncocytoma, and low in clear cell and papillary types.
  • The mRNA expression ratios among these genes (i.e., CA9/AMACR and AMACR/CLCNKB ratios) further accentuate the gene expression differences among these tumors, and a molecular diagnostic algorithm was established.
  • This algorithm accurately classified the 31 fresh-frozen tumors into 14 clear cell, 5 papillary, 6 chromophobe, and 6 oncocytomas.
  • In the formalin-fixed group, the molecular criteria accurately classified the cases into 15 clear cell, 16 papillary, and 32 in the chromophobe/oncocytoma group but could only separate some, but not all, oncocytomas from chromophobe RCC.
  • CONCLUSIONS: RNA expression ratios based on the four-gene panel can accurately classify subtypes of RCC as well as help distinguish some oncocytomas from chromophobe RCC.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Kidney Neoplasms / pathology. Neoplasm Proteins / genetics. RNA, Messenger / metabolism
  • [MeSH-minor] Adenocarcinoma, Clear Cell / genetics. Adenocarcinoma, Clear Cell / pathology. Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Algorithms. Anion Transport Proteins / genetics. Antigens, Neoplasm / genetics. Carbonic Anhydrases / genetics. Carcinoma, Renal Cell / genetics. Carcinoma, Renal Cell / pathology. Chloride Channels / genetics. Diagnosis, Differential. Humans. Membrane Proteins / genetics. Racemases and Epimerases / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods. beta-Defensins / genetics

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  • (PMID = 16166433.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anion Transport Proteins; 0 / Antigens, Neoplasm; 0 / CLCNKB protein, human; 0 / Chloride Channels; 0 / DEFB1 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / beta-Defensins; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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26. Gudbjartsson T, Hardarson S, Petursdottir V, Thoroddsen A, Magnusson J, Einarsson GV: Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases. BJU Int; 2005 Dec;96(9):1275-9
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  • [Title] Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases.
  • OBJECTIVE: To evaluate the clinical behaviour and pathology of renal oncocytoma in a well-defined population over a 30-year period.
  • PATIENTS AND METHODS: In a retrospective population-based study we assessed relevant clinical and pathological factors in 45 patients (31 men and 14 women) diagnosed with renal oncocytoma in Iceland between 1971 and 2000.
  • RESULTS: The age-standardized incidence was 0.3 per 100,000 per year for both men and women, the incidence of oncocytomas being 5.5% of renal cell carcinomas (RCCs) diagnosed during the same period in Iceland.
  • All the patients had a radical nephrectomy, except for one with bilateral oncocytoma who had a partial nephrectomy.
  • The mean (range) tumour size was 5.7 (0.9-12) cm.
  • Eighteen patients (58%) were diagnosed at Tumour-Node-Metastasis stage I, 10 at stage II (32%) and three at stage III (10%), all of those at stage III having renal capsular penetration or tumour invasion into perirenal fat tissue (T3aN0M0).
  • After a median follow-up of 8.3 years there were no recurrences or deaths from oncocytoma (100% disease-specific survival).
  • CONCLUSIONS: In most cases renal oncocytoma behaves like a benign tumour; the long-term prognosis is excellent.
  • Thus, in the present patients, radical nephrectomy could be regarded as an over-treatment and nephron-sparing surgery as more appropriate, especially in patients with small tumours.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging / methods. Retrospective Studies. Statistics, Nonparametric. Survival Analysis

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  • (PMID = 16287444.001).
  • [ISSN] 1464-4096
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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27. Rowsell C, Fleshner N, Marrano P, Squire J, Evans A: Papillary renal cell carcinoma within a renal oncocytoma: case report of an incidental finding of a tumour within a tumour. J Clin Pathol; 2007 Apr;60(4):426-8
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  • [Title] Papillary renal cell carcinoma within a renal oncocytoma: case report of an incidental finding of a tumour within a tumour.
  • The most common renal tumours are clear cell, papillary, chromophobe and collecting duct renal cell carcinomas (RCCs), and benign oncocytomas and angiomyolipomas.
  • Tumours with hybrid features between some of these entities have been recognised; in particular, tumours with features of both chromophobe RCC and oncocytoma.
  • Case reports describing one distinct type of primary renal tumour actually within another are very rare.
  • The incidental finding of a papillary RCC located in an oncocytoma in a nephrectomy specimen from a 75-year-old man is described.
  • Morphological criteria for each tumour type were completely satisfied and fluorescence in situ hybridisation detected the expected number of copies of chromosome 7 in the cells of each tumour type.
  • The cells in the papillary tumour contained three copies, whereas the oncocytoma cells contained only two per nucleus.
  • To our knowledge, this is the first report of a papillary RCC being identified within an oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Mixed Tumor, Malignant / pathology


28. Barrese JL, Lau S, Chen BT, Maghami E: Nonparotid parapharyngeal oncocytoma: a case report and literature review. Head Neck; 2010 Jun;32(6):800-5
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  • [Title] Nonparotid parapharyngeal oncocytoma: a case report and literature review.
  • Oncocytoma is a rare, benign salivary neoplasm composed of mitochondria-rich cells called oncocytes.
  • Although oncocytoma usually occurs in the parotid glands, it has much less commonly been reported to occur in minor salivary gland tissues.
  • Although there have been a few reported cases of oncocytomas being found in the parapharyngeal space, most if not all cases seem to be extensions of deep lobe parotid tumors.
  • Excision of the mass, through a transcervical approach, demonstrated it to be an isolated oncocytoma of the parapharyngeal space, noncontiguous with the parotid gland.
  • A brief review of the available literature examining the known body of knowledge regarding these neoplasms is presented.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Pharyngeal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Humans. Male. Oxyphil Cells / pathology. Positron-Emission Tomography

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc. Head Neck, 2010.
  • (PMID = 19787785.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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29. Shomori K, Nagashima Y, Kuroda N, Honjo A, Tsukamoto Y, Tokuyasu N, Maeta N, Matsuura K, Hijiya N, Yano S, Yokoyama S, Ito H, Moriyama M: ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas. Mod Pathol; 2007 Feb;20(2):199-207
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  • [Title] ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas.
  • Further, we immunohistochemically analyzed 100 renal tumors including 14 oncocytomas, and 86 renal cell carcinomas (RCCs).
  • We found that ARPP was highly expressed in 12 of the 14 (85.7%) oncocytomas, but was detectable in only four of the 86 (4.7%) RCCs.
  • Interestingly, ARPP was not detected in any of 11 chromophobe RCCs, suggesting that ARPP may be useful for differential diagnosis between oncocytoma and chromophobe RCC.
  • Immunoelectron microscopy with anti-ARPP antibody revealed that ARPP was localized in mitochondria and nuclei in both the normal distal renal tubule and oncocytoma, suggesting that oncocytoma may be derived from the distal nephron, and probably from part of the distal renal tubule.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Muscle Proteins / metabolism. Nuclear Proteins / metabolism. Repressor Proteins / metabolism
  • [MeSH-minor] Antibodies, Monoclonal / biosynthesis. Antibodies, Monoclonal / immunology. Biomarkers, Tumor / metabolism. Blotting, Western. Cell Nucleus / metabolism. Cell Nucleus / ultrastructure. Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. HeLa Cells. Humans. Immunoenzyme Techniques. Kidney Tubules, Distal / metabolism. Kidney Tubules, Distal / ultrastructure. Microscopy, Immunoelectron. Mitochondria / metabolism. Mitochondria / ultrastructure. Transfection

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  • (PMID = 17206105.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ANKRD2 protein, human; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Muscle Proteins; 0 / Nuclear Proteins; 0 / Repressor Proteins
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30. Archondakis S, Skagias L, Tsakiris A, Sambaziotis D, Daskalopoulou D: Oncocytoma of the lacrimal gland diagnosed initially by fine-needle aspiration cytology. Diagn Cytopathol; 2009 Jun;37(6):443-5

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  • [Title] Oncocytoma of the lacrimal gland diagnosed initially by fine-needle aspiration cytology.
  • Oncocytomas are benign tumors that infrequently involve ocular adnexa.
  • We describe a case of oncocytoma of the lacrimal gland which was initially diagnosed by fine-needle aspiration cytology.
  • The tumor was aspirated.
  • The cytoplasm of the tumor cells was rich in eosinophilic granules.
  • The initial cytological diagnosis was oncocytoma.
  • The tumor was then completely excised and the histological diagnosis confirmed the initial cytological one.
  • Oncocytoma is a rare entity which must be considered in differential diagnosis of a peripunctal mass in elderly patients.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Lacrimal Apparatus / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19217061.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Zubakov D, Stupar Z, Kovacs G: Differential expression of a new isoform of DLG2 in renal oncocytoma. BMC Cancer; 2006;6:106
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of a new isoform of DLG2 in renal oncocytoma.
  • BACKGROUND: Renal oncocytoma, a benign tumour of the kidney, may pose a differential diagnostic problem due to overlapping phenotype with chromophobe renal cell carcinoma or other types of renal cell tumours.
  • Therefore, identification of molecular markers would be of great value for molecular diagnostics of this tumour type.
  • METHODS: In the current study we applied various techniques, including Affymetrix microarray hybridization and semiquantitative RT-PCR, to identify genes expressed differentially in renal oncocytomas.
  • The new isoform is specifically upregulated in renal oncocytoma, whereas the known DLG2 gene is downregulated in this type of kidney tumour.
  • CONCLUSION: The new isoform of DLG2 is the promising candidate gene for molecular differential diagnostics of renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / genetics. Guanylate Kinase / genetics. Kidney Neoplasms / diagnosis. Kidney Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / genetics. Diagnosis, Differential. Down-Regulation. Genetic Markers. Humans. Nucleic Acid Amplification Techniques. Oligonucleotide Array Sequence Analysis. Protein Isoforms. Reverse Transcriptase Polymerase Chain Reaction. Up-Regulation

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  • [Cites] Hum Pathol. 2005 Jan;36(1):22-8 [15712178.001]
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  • (PMID = 16640776.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers; 0 / Protein Isoforms; 0 / Tumor Suppressor Proteins; EC 2.7.4.8 / DLG2 protein, human; EC 2.7.4.8 / Guanylate Kinase
  • [Other-IDs] NLM/ PMC1524971
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32. Neuzillet Y, Lechevallier E: [Renal oncocytoma]. Prog Urol; 2006 Apr;16(2):105-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Renal oncocytoma].
  • Due to its nonspecific clinical and radiological features, renal oncocytoma is usually diagnosed on the operative specimen.
  • Histological confirmation of the diagnosis is based on the distinction between oncocytoma and renal cell carcinoma (RCC), which can be difficult.
  • Description of cases in which RCC and oncocytoma are present in the same tumour and the hypothesis of a link between oncocytoma and RCC further complicate the diagnosis of this tumour by the urologist.
  • The authors reviewed the management of tumours suspected to be oncocytoma based on a review of the international literature concerning the diagnosis, natural history and treatment of renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms

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  • (PMID = 16734229.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 88
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33. Kloub O, Perry A, Tu PH, Lipper M, Lopes MB: Spindle cell oncocytoma of the adenohypophysis: report of two recurrent cases. Am J Surg Pathol; 2005 Feb;29(2):247-53
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  • [Title] Spindle cell oncocytoma of the adenohypophysis: report of two recurrent cases.
  • The recently described "spindle cell oncocytoma of the adenohypophysis" is a very rare and often misdiagnosed entity.
  • Herein, we present 2 cases of recurrent spindle cell oncocytomas.
  • Recently, both underwent transsphenoidal reexploration for recurrent "pituitary adenoma."
  • Ultimately, a partial resection was performed after compression of optic pathways by the tumor, and approximately 1 year later, re-resection was carried out.
  • The histopathologic features of these lesions are consistent with spindle cell oncocytoma of the adenohypophysis.
  • In summary, we are reporting 2 cases of recurrent spindle cell oncocytoma of adenohypophysis with longer follow-up than previously published cases, suggesting the possibility of a more aggressive behavior than has been initially considered.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Neoplasm Recurrence, Local / pathology. Pituitary Neoplasms / pathology

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  • (PMID = 15644783.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Choi YD, Kim KS, Ryu S, Park Y, Cho NH, Rha SH, Jang JJ, Ro JY, Juhng SW, Choi C: Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma. J Korean Med Sci; 2007 Apr;22(2):305-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma.
  • We tested the possibility that expression of claudin-7 could be used as a marker of renal tumors originating from the distal nephron.
  • We examined the immunohistochemical expression of claudin-7 and parvalbumin in 239 renal tumors, including 179 clear cell renal cell carcinoma (RCC)s, 29 papillary RCCs, 20 chromophobe RCCs, and 11 renal oncocytomas.
  • Claudin-7 and parvalbumin immunostains were positive in 3.4%, 7.8% of clear cell RCCs, 34.5%, 31.0% of papillary RCCs, 95.0%, 80.0% of chromophobe RCCs, and 72.7%, 81.8% of renal oncocytomas, respectively.
  • The expression pattern of claudin-7 was mostly diffuse in chromophobe RCC and was either focal or diffuse in oncocytoma.
  • Claudin-7 can be used as a useful diagnostic marker in diagnosing chromophobe RCC and oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / metabolism. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / diagnosis. Kidney Neoplasms / metabolism. Membrane Proteins / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Claudins. Humans. Neoplasm Proteins / metabolism. Nephrons / metabolism. Reproducibility of Results. Sensitivity and Specificity. Tissue Distribution. Tumor Cells, Cultured

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  • (PMID = 17449941.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN7 protein, human; 0 / Claudins; 0 / Membrane Proteins; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC2693599
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35. Li G, Barthelemy A, Feng G, Gentil-Perret A, Peoc'h M, Genin C, Tostain J: S100A1: a powerful marker to differentiate chromophobe renal cell carcinoma from renal oncocytoma. Histopathology; 2007 Apr;50(5):642-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] S100A1: a powerful marker to differentiate chromophobe renal cell carcinoma from renal oncocytoma.
  • AIMS: The common subtypes of renal tumours are conventional, papillary, chromophobe carcinoma and oncocytoma.
  • The morphological differentiation between chromophobe carcinoma and oncocytoma may be difficult.
  • METHODS AND RESULTS: Thirty-nine tumour samples [nine clear cell renal cell carcinomas (RCCs), six papillary RCCs, nine chromophobe RCCs and 15 oncocytomas] were studied.
  • Nine oncocytomas showed strong immunoreactivity for S100A1.
  • Four oncocytomas were scored as moderate and one as weak reactivity.
  • In total, 14/15 (93%) of oncocytomas were considered to be immunopositive.
  • S100A1 immunoreactivity was observed in 6/9 clear cell and 4/6 papillary carcinomas.
  • CONCLUSION: S100A1 may be a potentially powerful marker to differentiate the chromophobe RCC from renal oncocytoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology. S100 Proteins / metabolism


36. Akbulut S, Senol A, Cakabay B, Sezgin A: Giant renal oncocytoma: a case report and review of the literature. J Med Case Rep; 2010;4:52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant renal oncocytoma: a case report and review of the literature.
  • INTRODUCTION: Renal oncocytomas are benign neoplasms derived from cells of the distal renal tubule, and comprise 5% to 7% of primary renal neoplasms.
  • Oncocytomas are mostly asymptomatic, and the majority of tumors are discovered incidentally.
  • In this case report, we present a case of a patient with a giant oncocytoma arising from her left kidney.
  • The immunohistopathology of the mass was consistent with renal oncocytoma.
  • CONCLUSION: To the best of our knowledge, this is the second largest renal oncocytoma described in the English language literature.
  • This is also the first reported giant oncocytoma that presented during pregnancy.

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  • (PMID = 20205900.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827435
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37. Mazal PR, Exner M, Haitel A, Krieger S, Thomson RB, Aronson PS, Susani M: Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol; 2005 Jan;36(1):22-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma.
  • Distinguishing renal oncocytoma from chromophobe and other renal carcinomas is essential, considering their differing biological potentials.
  • Although renal oncocytoma is considered a benign tumor, chromophobe renal cell carcinoma has potentially malignant biological behavior.
  • But none of these features has proven to be reliably specific, especially in tumors with overlapping phenotypes.
  • We report a novel immunohistochemical approach based on the expression of a recently described kidney-specific cadherin (Ksp-cadherin) for the differential diagnosis of these 2 tumors.
  • We compared Ksp-cadherin expression in 212 renal tumors, including 102 clear cell renal carcinomas, 46 papillary renal cell carcinomas, 30 chromophobe carcinomas, 3 collecting duct carcinomas, and 31 oncocytomas.
  • We found that chromophobe renal cell carcinomas consistently (96.7% of cases) demonstrated a distinctive membrane pattern of Ksp-cadherin expression, whereas renal oncocytomas (3.2%), clear cell renal cell carcinomas (0%), papillary renal cell carcinomas (2.2%), and collecting duct carcinomas (0%) usually did not express Ksp-cadherin.
  • CK7 expression was found in 90.0%, 6.5%, 7.8%, 76.1%, and 33.3% of these tumor cases, respectively.
  • Whereas CK7 was detected in different types of renal cell carcinomas, Ksp-cadherin was expressed almost exclusively in chromophobe renal cell carcinomas.
  • Immunohistochemical analysis of Ksp-cadherin offers a fast, reliable approach for the distinguishing between renal oncocytoma and chromophobe renal cell carcinoma that is applicable for routine pathology laboratory studies without the need for time-consuming and costly ancillary studies.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma, Papillary / metabolism. Adenoma, Oxyphilic / metabolism. Biomarkers, Tumor / analysis. Cadherins / biosynthesis. Kidney Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Blotting, Western. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Middle Aged


38. Alvarez Ardura M, Hernández Cañas V, de la Morena Gallego JM, Rengifo Abbad D, González-Chamorro Ladrón de Guevara F, Llorente Abarca C: [Giant renal oncocytoma]. Actas Urol Esp; 2005 Sep;29(8):791-3
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  • [Title] [Giant renal oncocytoma].
  • Renal oncocytoma is a benign neoplasms arising from cells of the distal renal tubule.
  • They acount for 3-7% of all renal tumors. most are incidental findings.
  • Differential diagnosis with renal cells carcinoma is often difficult.
  • Here we report a case of big renal oncocytoma as an incidental finding while performing an abdominal ultrasound in a patient with low abdominal pain.
  • [MeSH-major] Adenoma, Oxyphilic / radiography. Kidney Neoplasms / radiography

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  • (PMID = 16304913.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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39. Mayr JA, Meierhofer D, Zimmermann F, Feichtinger R, Kögler C, Ratschek M, Schmeller N, Sperl W, Kofler B: Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma. Clin Cancer Res; 2008 Apr 15;14(8):2270-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma.
  • PURPOSE: Many solid tumors exhibit abnormal aerobic metabolism characterized by increased glycolytic capacity and decreased cellular respiration.
  • Recently, mutations in the nuclear encoded mitochondrial enzymes fumarate hydratase and succinate dehydrogenase have been identified in certain tumor types, thus demonstrating a direct link between mitochondrial energy metabolism and tumorigenesis.
  • Although mutations in the mitochondrial genome (mitochondrial DNA, mtDNA) also can affect aerobic metabolism and mtDNA alterations are frequently observed in tumor cells, evidence linking respiratory chain deficiency in a specific tumor type to a specific mtDNA mutation has been lacking.
  • EXPERIMENTAL DESIGN: To identify mitochondrial alterations in oncocytomas, we investigated the activities of respiratory chain enzymes and sequenced mtDNA in 15 renal oncocytoma tissues.
  • RESULTS: Here, we show that loss of respiratory chain complex I (NADH/ubiquinone oxidoreductase) is associated with renal oncocytoma.
  • Enzymatic activity of complex I was undetectable or greatly reduced in the tumor samples (n = 15).
  • Mutation analysis of the mtDNA showed frame-shift mutations in the genes of either subunit ND1, ND4, or ND5 of complex I in 9 of the 15 tumors.
  • CONCLUSION: Our data indicate that isolated loss of complex I is a specific feature of renal oncocytoma and that this deficiency is frequently caused by somatic mtDNA mutations.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. DNA, Mitochondrial / genetics. Electron Transport Complex I / analysis. Kidney Neoplasms / genetics. Mutation

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  • (PMID = 18413815.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; EC 1.6.5.3 / Electron Transport Complex I
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40. Geramizadeh B, Ravanshad M, Rahsaz M: Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):167-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma.
  • Renal oncocytoma, conventional RCC (granular cell type) and chromophobe RCC have different prognosis.
  • In a 5-year study of 128 renal tumors, we selected 76 cases [30 conventional RCC (CRCC), 16 papillary RCC, 21 chromophobe RCC (ChRCC), 8 oncocytoma, 1 collecting duct carcinoma (cdc)] and staining with Hale's colloidal iron, CK7, CK8, CK18, CK19, CK20, Vimentin, EMA, CD10 and RCC marker were done.
  • No significant difference was seen between renal tumor subtypes with CK8, CK18, CK19, CK20 and EMA.
  • Hale's colloidal iron staining with diffuse reticular fine cytoplasmic pattern was present in ChRCCs, but was absent in other subtypes and oncocytomas.
  • Vimentin, CK7, CD10, RCC marker and Hale's colloidal iron can be used for the differential diagnosis of problematic epithelial tumors of kidney (CRCC, ChRCC and oncocytoma) - i.e.
  • ChRCC: Vimentin, CD10 and RCC marker - negative, CK7 - positive and positive diffuse fine reticular cytoplasmic pattern of Hale's colloidal iron; oncocytoma: Vimentin, CK7, RCC marker and CD10 - negative and Hale's colloidal iron - negative; CRCC: CK7 - negative, Vimentin, CD10 and RCC marker - positive and Hale's colloidal iron - negative.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Keratin-7 / metabolism. Male. Middle Aged. Mitogen-Activated Protein Kinases / metabolism. Neprilysin / metabolism. Vimentin / metabolism


41. Aslam MI, Spencer L, Garcea G, Pollard C, Metcalfe MS, Harrison RF, Dennison AR: A case of liver metastasis from an oncocytoma with a focal area of chromophobe renal cell carcinoma: a wolf in sheep's clothing. Int J Surg Pathol; 2009 Apr;17(2):158-62
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  • [Title] A case of liver metastasis from an oncocytoma with a focal area of chromophobe renal cell carcinoma: a wolf in sheep's clothing.
  • In 2004, the World Health Organization classified the renal oncocytomas as benign neoplasms of the kidney.
  • There are reports of subtypes of renal tumors, with similar histological morphology to oncocytoma, but with malignant potential, one of these tumors is the eosinophilic variant of chromophobe renal cell carcinoma.
  • It is important to characterize the histological features and the subtype of tumor, as this predicts biological behavior and cancer-specific survival rate.
  • A rare case of a liver metastasis from a focal area of eosinophilic variant of chromophobe renal cell carcinoma mixed in oncocytoma in a 69-year-old woman is reported.
  • Although some renal tumors may contain oncocytoma and eosinophilic variant of chromophobe renal cell carcinoma histology, caution should be exercised while diagnosing oncocytomas in needle biopsies as there may be unsampled area of chromophobe carcinoma which has a potential for metastatic spread representing a wolf in sheep's clothing.
  • [MeSH-major] Adenoma, Oxyphilic / secondary. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Liver Neoplasms / secondary


42. Garcia E, Li M: Caveolin-1 immunohistochemical analysis in differentiating chromophobe renal cell carcinoma from renal oncocytoma. Am J Clin Pathol; 2006 Mar;125(3):392-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Caveolin-1 immunohistochemical analysis in differentiating chromophobe renal cell carcinoma from renal oncocytoma.
  • Chromophobe renal cell carcinoma (ChRCC) and oncocytoma might mimic each other histologically.
  • We studied the immunohistochemical staining pattern of caveolin-1 in 21 ChRCCs and 26 oncocytomas and compared it with cytokeratin (CK) 7 to evaluate its usefulness in differentiating these 2 neoplasms.
  • All 21 ChRCCs (100%) were positive for caveolin-1, 20 of which were stained in 20% or more of the tumor cells.
  • In contrast, only 3 (12%) of 26 oncocytomas showed positivity in fewer than 20% tumor cells and 23 (88%) of 26 were negative.
  • All 21 ChRCCs (100%) were positive for CK7, with 18 (86%) stained in 20% or more of the tumor cells and 3 (14%) in fewer than 20%.
  • Of 26 oncocytomas, 25 (96%) were positive for CK7, with 7 (27%) stained in 20% or more of the tumor cells and 18 (69%) in fewer than 20%.
  • These results strongly suggest that caveolin-1 immunohistochemical analysis is useful for differentiating ChRCC from oncocytoma and is superior to CK7.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Caveolin 1 / analysis. Kidney Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Count. Diagnosis, Differential. Humans. Immunohistochemistry. Keratin-7. Keratins / analysis. Kidney / chemistry. Kidney / pathology


43. Radopoulos D, Tzakas K, Tahmatzopoulos A: A rare case of renal oncocytoma associated with erythrocytosis: case report. BMC Urol; 2006;6:26
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  • [Title] A rare case of renal oncocytoma associated with erythrocytosis: case report.
  • BACKGROUND: Oncocytomas are benign tumors of the kidney that are usually diagnosed postoperatively due to differential diagnostic problems from renal cell carcinoma.
  • Although the latter are neoplasms that have been associated with erythrocytosis in 3.5% of cases, there are no reports in the literature about a similar occurrence in oncocytomas.
  • CASE PRESENTATION: In this case report we present a unique case of a right lower pole oncocytoma associated with erythrocytosis.
  • CONCLUSION: Erythrocytosis can sometimes occur in association with renal oncocytomas.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Adenoma, Oxyphilic / diagnosis. Kidney Neoplasms / complications. Kidney Neoplasms / diagnosis. Polycythemia / complications. Polycythemia / diagnosis

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  • [Cites] J Urol. 2004 Mar;171(3):1066-70 [14767272.001]
  • [Cites] Eur Urol. 1992;21(2):160-3 [1499617.001]
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  • (PMID = 16995951.001).
  • [ISSN] 1471-2490
  • [Journal-full-title] BMC urology
  • [ISO-abbreviation] BMC Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1590043
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44. Lim YJ, Lee SM, Shin JH, Koh HC, Lee YH: Virilizing adrenocortical oncocytoma in a child: a case report. J Korean Med Sci; 2010 Jul;25(7):1077-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Virilizing adrenocortical oncocytoma in a child: a case report.
  • Functioning adrenocortical oncocytomas are extremely rare and most reported patients are 40-60 yr of age.
  • To our knowledge, only 2 cases of functioning adrenocortical oncocytomas have been reported in childhood.
  • We report a case of functioning adrenocortical oncocytoma in a 14-yr-old female child presenting with virilization.
  • The completely resected tumor composed predominantly of oncocytes without atypical mitosis and necrosis.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Adrenal Cortex Neoplasms / complications. Virilism / etiology

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  • [Cites] Int J Surg Pathol. 2003 Oct;11(4):325-9 [14615833.001]
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  • (PMID = 20592902.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2890887
  • [Keywords] NOTNLM ; Adenoma, Oxyphilic / Adrenal Cortex Neoplasms / Child / Virilism
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45. Trpkov K, Yilmaz A, Uzer D, Dishongh KM, Quick CM, Bismar TA, Gokden N: Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. Histopathology; 2010 Dec;57(6):893-906
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features.
  • AIM: To evaluate problematic diagnostic features in renal oncocytoma.
  • METHODS AND RESULTS: One hundred and nine cases of oncocytoma were reviewed and the problematic gross and microscopic features recorded.
  • Multifocal and bilateral neoplasms were found in 12 (11%) and five (4.6%) cases, respectively.
  • Haemorrhage was seen grossly in 30 (27.5%) neoplasms and a central scar was identified in 35 (32.1%).
  • On microscopy, perinephric fat extension was present in 17 (15.6%) neoplasms and vascular extension was identified in four (3.7%) oncocytomas.
  • Focal clear cell changes were found in 16 (14.7%) oncocytomas, typically within hyalinized areas.
  • Limited foci with chromophobe-like histology (not exceeding 5% of the neoplasm) were found in 13 (11.9%) oncocytomas.
  • In 12 (11%) oncocytomas, rare papillary formations were noted in the lumina of microcysts.
  • Significant nuclear atypia, oncoblasts and entrapped tubules were identified in 27 (24.8%), 41 (37.6%) and 40 (36.7%) neoplasms, respectively.
  • After a median follow-up of 52 months (range 1-113 months), there was no disease recurrence, progression or death attributed to oncocytoma.
  • CONCLUSIONS: The recognition of the spectrum of morphological changes observed in renal oncocytoma should help pathologists establish a diagnosis of oncocytoma in problematic cases.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Necrosis. Retrospective Studies

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  • [Copyright] © 2010 Blackwell Publishing Limited.
  • (PMID = 21166703.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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46. Botsios D, Blouhos K, Vasiliadis K, Asimaki A, Tsalis K, Betsis D: Adrenocortical oncocytoma -- a rare tumor of undefined malignant potential: report of a case. Surg Today; 2007;37(7):612-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenocortical oncocytoma -- a rare tumor of undefined malignant potential: report of a case.
  • Adrenocortical oncocytomas are exceptionally rare.
  • We report a case of adrenocortical oncocytoma diagnosed by pathological examination of an extirpated right adrenal mass in a young woman.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adrenal Cortex Neoplasms / diagnosis

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  • (PMID = 17593485.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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47. Deshpande A, Munshi M: Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report. Indian J Pathol Microbiol; 2005 Apr;48(2):230-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report.
  • Renal oncocytomas are rare renal parenchymal neoplasms which have a good prognosis.
  • Cytologic findings in a case of renal oncocytoma are presented.
  • The resected specimen showed the characteristic findings of oncocytoma.
  • Renal oncocytoma has to be distinguished from granular renal cell carcinoma (RCC) and chromophobe cell carcinoma, because of the markedly different prognosis.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology

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  • (PMID = 16758678.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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48. Salido M, Lloreta J, Melero C, García M, Placer J, Espinet B, Villa O, Bielsa O, Gelabert-Mas A, Serrano S, Solé F: Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma. Cancer Genet Cytogenet; 2005 Dec;163(2):160-3
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  • [Title] Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma.
  • We report the case of a 43-year-old male with multiple tumor foci showing microscopic features of chromophobe renal carcinoma (ChRCC) arising in an oncocytoma.
  • Conventional cytogenetics of fresh tumor cells and fluorescence in situ hybridization (FISH) revealed the following abnormal karyotype: 46,XY,der(8)ins(8;11)(p?
  • To our knowledge, chromosome 8 has not been reported as a partner involved in structural rearrangements of 11q13 in oncocytomas.
  • FISH in paraffin tissue sections revealed a rearrangement of CCND1 (11q13) in the oncocytoma cells.
  • The multiple foci of chromophobe carcinoma presented multiple copies of CCND1, suggesting that they represented a transformation from oncocytoma into ChRCC.
  • There was immunohistochemical overexpression of CCND1 in both oncocytoma and chromophobe carcinoma cells.
  • In this case, the correlation of the microscopic findings with changes in CCND1 gene associated to CCND1 overexpression in both components suggest that the ChRCC would have originated from the preexisting oncocytoma.
  • FISH techniques on paraffin tissue sections may help to identify genetic aberrations such as CCND1 rearrangement in order to establish a diagnosis of oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Renal Cell / genetics. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 8. Kidney Neoplasms / genetics
  • [MeSH-minor] Adult. Cell Transformation, Neoplastic. Chromosome Banding. Cyclin D1 / genetics. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Karyotyping. Male


49. Pazooki A, Vaziri M: Incidental adrenocortical oncocytoma. BMJ Case Rep; 2009;2009
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  • [Title] Incidental adrenocortical oncocytoma.
  • Laparascopic left adrenalectomy and subsequent pathologic examination demonstrated a 8×6.5×4 cm oncocytoma.
  • Adrenocortical oncocytoma is an exceptionally rare tumour, mainly non-functional and benign, that should be considered in the differential diagnosis of adrenal "incidentalomas".

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  • [Cites] Obstet Gynecol. 2001 Nov;98(5 Pt 2):916-8 [11704201.001]
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  • (PMID = 21686335.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027851
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50. McHugh JB, Hoschar AP, Dvorakova M, Parwani AV, Barnes EL, Seethala RR: p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. Head Neck Pathol; 2007 Dec;1(2):123-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma.
  • Metastatic renal cell carcinoma (RCC) can pose diagnostic challenges in the head and neck often resembling benign and malignant oncocytic lesions.
  • We have noticed that p63 routinely stains salivary gland oncocytomas but not metastatic RCC.
  • Nineteen oncocytomas, 9 cases of oncocytosis, 9 oncocytic carcinomas and 16 head and neck metastatic RCC were studied.
  • Morphologic features evaluated were cytoplasmic character (clear versus oncocytic), Fuhrman nuclear grade, mitotic rate, growth pattern, presence of lumens/blood lakes and stromal characteristics.
  • Tumors were stained with antibodies to p63, renal cell carcinoma marker (RCCm), CD10, and vimentin.
  • Eight benign oncocytic tumors (29%) had clear cell features while 6 metastatic RCC (37%) had oncocytic features.
  • Median Fuhrman nuclear grade was 2 in oncocytoma and oncocytosis and 3 both oncocytic carcinoma and metastatic RCC.
  • Mitotic rates were only significantly different between benign oncocytic tumors and metastatic RCC.
  • All oncocytomas had lumina compared to half of metastatic RCC, all of which also demonstrated blood lakes.
  • Seven benign oncocytic tumors (25%) and 5 oncocytic carcinomas (56%) had RCC-like vascular stroma.
  • All primary salivary gland tumors were positive for p63, predominately in basal cell-type distribution.
  • While clinical history and morphology usually are adequate, demonstration of p63 staining can definitively exclude metastatic RCC from the differential diagnosis of similar appearing tumors in salivary glands, namely oncocytoma and oncocytic carcinoma, with 100% specificity and sensitivity.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / metabolism. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Predictive Value of Tests

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  • (PMID = 20614263.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins
  • [Other-IDs] NLM/ PMC2807526
  • [Keywords] NOTNLM ; Metastatic renal cell carcinoma / Oncocytic carcinoma / Oncocytoma / p63
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51. Osunkoya AO, Cohen C, Lawson D, Picken MM, Amin MB, Young AN: Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. Hum Pathol; 2009 Feb;40(2):206-10
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  • [Title] Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.
  • In a recent oligonucleotide microarray study, we identified claudin-7 and claudin-8 as candidate markers to distinguish chromophobe renal cell carcinoma from other renal tumors, including oncocytoma.
  • Distinction of these lesions can be difficult by light microscopy but is clinically important because chromophobe renal cell carcinoma has malignant biological potential, whereas renal oncocytoma is benign.
  • Claudin-7 and claudin-8 expression was studied by immunohistochemistry in 11 chromophobe renal cell carcinomas and 17 oncocytomas using formalin-fixed paraffin-embedded tissue sections of tumor with adjacent nonneoplastic kidney.
  • Specificity was verified by negative control reactions without primary antibody and appropriate membranous staining patterns in positive control tissues (colon carcinoma and adjacent nonneoplastic kidney).
  • Claudin-7 protein was expressed in a membranous pattern in 10 of 11 chromophobe renal cell carcinomas and 4 of 17 oncocytomas (P < .01).
  • Claudin-8 was expressed in multiple patterns: In oncocytoma, 11 of 17 cases showed cytoplasmic, 4 of 17 membranous, and 2 of 17 negative reactions.
  • In chromophobe renal cell carcinoma, 0 of 11 cases showed cytoplasmic, 3 of 11 membranous, and 8 of 11 negative reactions (P < .01).
  • The immunohistochemical pattern of membranous claudin-7 and negative claudin-8 was seen in 7 of 11 chromophobe renal cell carcinomas and 1 of 17 oncocytomas (63% sensitivity, 84% specificity, 88% positive predictive value for chromophobe renal cell carcinoma).
  • Negative claudin-7 and cytoplasmic claudin-8 were observed in 10 of 17 oncocytomas and 0 of 11 chromophobe renal cell carcinomas (59% sensitivity, 100% specificity and positive predictive value for oncocytoma).
  • The distal nephron proteins claudin-7 and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma.
  • Expression of claudin-7 and claudin-8 may reflect the relationship of chromophobe renal cell carcinoma and oncocytoma to intercalated cells of the cortical collecting duct.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Claudins. Diagnosis, Differential. Humans. Immunohistochemistry. Sensitivity and Specificity


52. Liu L, Qian J, Singh H, Meiers I, Zhou X, Bostwick DG: Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. Arch Pathol Lab Med; 2007 Aug;131(8):1290-7
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  • [Title] Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis.
  • CONTEXT: The separation of chromophobe renal cell carcinoma, oncocytoma, and clear cell renal cell carcinoma using light microscopy remains problematic in some cases.
  • OBJECTIVE: To determine a practical immunohistochemical panel for the differential diagnosis of chromophobe carcinoma.
  • DESIGN: Vimentin, glutathione S-transferase alpha (GST-alpha), CD10, CD117, cytokeratin (CK) 7, and epithelial cell adhesion molecule (EpCAM) were investigated in 22 cases of chromophobe carcinoma, 17 cases of oncocytoma, and 45 cases of clear cell carcinoma.
  • RESULTS: Vimentin and GST-alpha expression were exclusively observed in clear cell carcinoma.
  • CD10 staining was more frequently detected in clear cell carcinoma (91%) than in chromophobe carcinoma (45%) and oncocytoma (29%).
  • CD117 was strongly expressed in chromophobe carcinoma (82%) and oncocytoma (100%), whereas none of the cases of clear cell carcinomas were immunoreactive.
  • Cytokeratin 7 was positive in 18 (86%) of 22 cases of chromophobe carcinoma, whereas all oncocytomas were negative for CK7.
  • EpCAM protein was expressed in all 22 cases of chromophobe carcinoma in more than 90% of cells, whereas all EpCAM-positive oncocytomas (5/17; 29%) displayed positivity in single cells or small cell clusters.
  • CONCLUSIONS: Using the combination of 3 markers (vimentin, GST-alpha, and EpCAM), we achieved 100% sensitivity and 100% specificity for the differential diagnosis of chromophobe carcinoma, oncocytoma, and clear cell carcinoma.
  • The pattern of "vimentin(-)/GST-alpha(-)" effectively excluded clear cell carcinoma, and homogeneous EpCAM expression confirmed the diagnosis of chromophobe carcinoma rather than oncocytoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Immunoenzyme Techniques / methods. Kidney Neoplasms / diagnosis. Neoplasm Proteins / analysis


53. Badmus TA, Adesunkanmi AR, Agbakwuru CA, Salako AA, Uhunmwagho O, Eziyi AK: Giant renal oncocytoma masquerading as infiltrating renal cell carcinoma: case report and literature review. Cent Afr J Med; 2006 Jan-Feb;52(1-2):16-9
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  • [Title] Giant renal oncocytoma masquerading as infiltrating renal cell carcinoma: case report and literature review.
  • Renal oncocytomas (RO) are tumours containing a population of cells with highly differentiated eosinophilic granular cytoplasm, extremely rich in mitochondria.
  • It is estimated they account for about 3 to 7% of all solid renocortical tumours that were previously regarded as renal cell carcinoma.
  • Based on their clinical behaviour and distinct pathologic features they are now regarded as benign renal tumours, often less than 5cm in diameter.
  • We present a case of giant renal oncocytoma in a patient with synchronous bladder tumour, with pre-operative clinical, urographic and ultrasound features of locally advanced renal cell carcinoma (RCC).
  • Findings at surgery included huge right renal tumour with infiltration to the duodenum; hepatic colic flexure; gall bladder; liver capsule and the greater omentum with small indurations at the base of the bladder.
  • There was no tumour extension to the renal vein, no peritoneal seedling, no nodal metastasis and no ascites.
  • In view of the difficulties at establishing pre-operative diagnosis in this disease and because nephron-sparing surgery is curative, especially for the well-circumscribed tumours, RO should be considered in the management of patients with features of infiltrating RCC.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 17892235.001).
  • [ISSN] 0008-9176
  • [Journal-full-title] The Central African journal of medicine
  • [ISO-abbreviation] Cent Afr J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Zimbabwe
  • [Number-of-references] 37
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54. Yen TH, Chen Y, Lin JL, Ng KF: Renal oncocytoma in Taiwan. Ren Fail; 2006;28(2):141-7
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  • [Title] Renal oncocytoma in Taiwan.
  • BACKGROUND: Renal oncocytoma has been repeatedly reported in Western countries, but only a few cases have been reported in Eastern countries.
  • This study aims to review the clinical course of renal oncocytoma in an Eastern country such as Taiwan.
  • MATERIALS AND METHODS: Sixteen cases of renal oncocytoma seen between 1987 and 2002 at Chang Gung Memorial Hospital, Taipei, Taiwan, were studied.
  • RESULTS: Preoperatively, all patients were diagnosed to have renal cell carcinoma, following various radiologic studies.
  • Perioperatively, frozen sections of three patients indicated renal oncocytoma in two and renal cell carcinoma in one.
  • Renal oncocytoma has marked similarities to renal cell carcinoma, according to various radiologic, cytologic, and pathological investigations, so an accurate diagnosis is difficult to achieve, either preoperatively or perioperatively.
  • Notably, all patients survived with no evidence of tumor recurrence.
  • CONCLUSIONS: The experience in Taiwan is generally that renal oncocytoma behaves benignly, as reported in other areas.
  • The excellent prognosis associated with this tumor appears to indicate that partial nephrectomy may suffice for removing the tumor, while sparing other unaffected renal parenchyma.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms
  • [MeSH-minor] Aged. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Nephrectomy. Taiwan

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  • (PMID = 16538972.001).
  • [ISSN] 0886-022X
  • [Journal-full-title] Renal failure
  • [ISO-abbreviation] Ren Fail
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Adley BP, Papavero V, Sugimura J, Teh BT, Yang XJ: Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. Anal Quant Cytol Histol; 2006 Aug;28(4):228-36
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  • [Title] Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma.
  • STUDY DESIGN: CK7 and parvalbumin mRNA expression levels in 23 oncocytomas and 32 chromophobe renal cell carcinomas (RCCs) were examined using gene expression microarrays.
  • Immunohistochemistry was performed using monoclonal antibodies specific for CK7 or parvalbumin in 41 chromophobe RCCs and 55 oncocytomas.
  • RESULTS: CK7 mRNA was overexpressed in 18 of 32 chromophobe RCCs but only 3 of 23 oncocytomas.
  • Parvalbumin mRNA was overexpressed in 15 of 32 chromophobe RCCs and only 4 of 23 oncocytomas.
  • In contrast, CK7 mRNA underexpression was noted in 13 of 23 oncocytomas and only 6 of 32 chromophobe RCCs, while parvalbumin underexpression was seen in 14 of 23 oncocytomas but only 6 of 32 chromophobe RCCs.
  • By immunohistochemistry, 27 of 41 (66%) chromophobe RCCs expressed CK7 diffusely compared to only 3 of 55 (5%) oncocytomas.
  • Diffuse parvalbumin expression was seen in all 41 of 41 (100%) chromophobe RCCs and only in 26 of 55 (47%) oncocytomas.
  • CONCLUSION: Both mRNA and protein expression levels of CK7 appear significantly higher in chromophobe RCC compared to oncocytoma (p < 0.001).
  • Parvalbumin expression is less specific but often displays a patchy pattern in oncocytomas.
  • Our study provides further evidence that CK7 and parvalbumin immunostains may be useful in differentiating oncocytoma from chromophobe RCC in problematic cases.
  • Negative or patchy staining (< 50% cells) for CK7 and/or parvalbumin strongly favors the diagnosis of oncocytoma.


56. Calle CA, Castillo IG, Eagle RC, Daza MT: Oncocytoma of the lacrimal gland: case report and review of the literature. Orbit; 2006 Sep;25(3):243-7
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  • [Title] Oncocytoma of the lacrimal gland: case report and review of the literature.
  • OBJECTIVE: Oncocytomas of the lacrimal gland are rare tumors.
  • Computed tomography and magnetic resonance imaging of brain and orbit demonstrated a right intraorbital extraconal soft tissue density mass that involved the lacrimal gland, upper eyelid and encroached both the superior oblique and superior rectus muscles.
  • Histopathology showed a benign oncocytoma that replaced most of the lacrimal gland.
  • CONCLUSION: Although rare, oncocytomas should be included in the differential diagnosis of any lacrimal gland tumors.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Eye Neoplasms / diagnosis. Lacrimal Apparatus Diseases / diagnosis

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  • (PMID = 16987774.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 16
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57. Burger M, Denzinger S, Filbeck T, Hartmann A, Rössler W, Hammerschmied C: A metachronous, atypical, multifocal renal oncocytoma with a concomitant renal cell carcinoma of the contralateral side and bilateral multifocal oncocytomas: two case reports and review of literature. ScientificWorldJournal; 2005 Jul 20;5:545-9
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  • [Title] A metachronous, atypical, multifocal renal oncocytoma with a concomitant renal cell carcinoma of the contralateral side and bilateral multifocal oncocytomas: two case reports and review of literature.
  • We present one case of a metachronous, atypical, multifocal renal oncocytoma with a concomitant chromophobe renal cell carcinoma (RCC) of the contralateral side and one case of bilateral and multifocal oncocytomas.
  • Oncocytomas are benign renal tumours that rarely appear bilateral or multifocal or with coexisting RCC.
  • The first case was a 63 years old patient presenting with a history of nephrectomy for a pT1 G1 pN0 R0 papillary RCC 4 years prior to presentation, showed two tumours of a singular kidney.
  • Upon nephron-sparing surgery one typical and one atypical oncocytoma with an invasion of the perinephric fat were found.
  • Both tumours revealed genetic alterations with loss of genetic material on chromosome 1p.
  • The second case was a 62 years old patient presenting with multifocal and bilateral renal tumours of undeclared dignity upon imaging.
  • During open exploration all tumours could be removed by nephron-sparing surgery and were identified as oncocytomas.
  • All 4 tumours revealed genetic alterations with loss of genetic material on chromosome 1p, one of the tumours an additional loss of chromosome 10.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Chromosome Deletion. Chromosomes, Human, Pair 1 / ultrastructure. Chromosomes, Human, Pair 10 / ultrastructure. DNA, Neoplasm / genetics. Diagnosis, Differential. Follow-Up Studies. Humans. Incidental Findings. Middle Aged. Nephrectomy / methods. Nucleic Acid Hybridization. Remission Induction

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  • (PMID = 16075151.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Number-of-references] 12
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58. Anastasiadis A, Dimitriadis G, Radopoulos D: Incidental giant renal oncocytoma: a case report. J Med Case Rep; 2010;4:358

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  • [Title] Incidental giant renal oncocytoma: a case report.
  • INTRODUCTION: Large renal oncocytomas are not very rare entities.
  • To the best of our knowledge, we report one of the largest oncocytomas in the English literature.
  • The tumor was incidentally diagnosed and, based on the preoperative clinical and radiographic findings, was therefore considered to be a renal cell carcinoma.
  • A radical nephrectomy was performed through a left flank intercostal incision and the pathology diagnosed renal oncocytoma.
  • Unfortunately, most renal oncocytomas cannot be differentiated from malignant renal cell carcinomas by clinical or radiographic criteria.
  • These tumors are treated operatively with radical or partial nephrectomy or thermal ablation, depending on the clinical circumstances.

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  • (PMID = 21059248.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2990760
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59. Rao Q, Liu XH, Zhou HB, Ma HH, Lu ZF, Zhou XJ: Expression analysis of Wnt-5a in renal epithelial neoplasms: distinguishing renal oncocytoma from a wide spectrum of renal cell carcinomas. Tumori; 2010 Mar-Apr;96(2):304-9
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  • [Title] Expression analysis of Wnt-5a in renal epithelial neoplasms: distinguishing renal oncocytoma from a wide spectrum of renal cell carcinomas.
  • OBJECTIVE: To study the expression of a novel marker, Wnt-5a, in renal epithelial neoplasms and determine its clinicopathological significance.
  • METHODS: Immunohistochemical analysis of Wnt-5a was carried out in normal human kidney samples as well as in 123 primary renal epithelial neoplasms including 37 clear cell renal cell carcinomas (RCCs), 24 papillary RCCs (15 type 1 and 9 type 2), 25 chromophobe RCCs, 11 Xp11 translocation carcinomas, 6 mucinous tubular and spindle cell carcinomas, and 20 oncocytomas.
  • RESULTS: Wnt-5a was expressed in 18.9% (7/37) of clear cell RCCs, 12.5% (3/24) of papillary RCCs, 16% (4/25) of chromophobe RCCs, 18.2% (2/11) of Xp11 translocation carcinomas, 0% (0/6) of mucinous tubular and spindle cell carcinomas, and 100% (20/20) of oncocytomas.
  • There was a significant difference in Wnt-5a immunohistochemistry between renal oncocytoma and the other subtypes of RCC (P < 0.01).
  • CONCLUSIONS: Our results indicate that Wnt-5a is a potentially useful immunohistochemical marker for the complex differential diagnosis between oncocytoma and other subtypes of RCC and also suggest that Wnt-5a may be a tumor suppressor gene in RCC.
  • [MeSH-major] Adenoma, Oxyphilic / chemistry. Carcinoma, Renal Cell / chemistry. Kidney Neoplasms / chemistry. Neoplasms, Glandular and Epithelial / chemistry. Proto-Oncogene Proteins / analysis. Wnt Proteins / analysis

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  • (PMID = 20572590.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / WNT5A protein, human; 0 / Wnt Proteins
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60. Bonfils P, Frydman E, Meatchi T, Mimoun M, De Preobrajenski N: [Masseter oncocytoma of parotid origin]. Rev Stomatol Chir Maxillofac; 2007 Jun;108(3):218-21
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  • [Title] [Masseter oncocytoma of parotid origin].
  • INTRODUCTION: Tumors developed in a salivary ectasia of the parotid gland are very rare.
  • The authors describe a case of oncocytoma developed in such an ectopy.
  • OBSERVATION: The tumor located in the parotid region was observed in a 79-year old man.
  • MRI was the most helpful to localize and characterize the tumor.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Choristoma / pathology. Masseter Muscle / pathology. Parotid Gland

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  • (PMID = 17363020.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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61. Fiske J, Patel R, Kau E, Pappas JG, Garcia RA, Taneja SS: Multifocal renal oncocytoma in a patient with Von Hippel-Lindau mutation. Urology; 2005 Dec;66(6):1320
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  • [Title] Multifocal renal oncocytoma in a patient with Von Hippel-Lindau mutation.
  • Von Hippel-Lindau disease (VHL) is a rare genetic disease with a lifetime risk of clear cell renal cell carcinoma in approximately 70% of cases.
  • Pathology of all renal masses revealed oncocytoma.
  • To our knowledge, we describe the first reported case of multiple renal oncocytomas in a male patient with a germline VHL mutation.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Kidney Neoplasms / genetics. von Hippel-Lindau Disease / genetics


62. Krüger S, Sotlar K, Kausch I, Horny HP: Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. Oncology; 2005;68(2-3):269-75
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  • [Title] Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma.
  • OBJECTIVE: Overexpression of KIT (CD117), a tyrosine kinase receptor, has been reported in a variety of tumors, some of which are susceptible to therapy with imatinib mesylate.
  • Our aim was to analyze KIT expression immunohistochemically in renal cell carcinomas (RCCs) and in oncocytomas.
  • METHODS: Routinely processed, paraffin-embedded specimens from 61 RCCs and 13 renal oncocytomas were investigated immunohistochemically.
  • Cytoplasmic and membrane-bound KIT staining of tumor cells was determined semiquantitatively.
  • RESULTS: All cases of oncocytomas and chromophobe RCCs showed membrane-bound KIT positivity, while about three-quarters of cases showed cytoplasmic reactivity.
  • Within the group of chromophobe RCCs, negative cytoplasmatic KIT reactivity was significantly correlated with advanced tumor stage (pT > or = 2; p = 0.036).
  • CONCLUSIONS: KIT expression is a hallmark of oncocytoma and chromophobe RCC.
  • [MeSH-major] Adenoma, Oxyphilic / chemistry. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / chemistry. Kidney Neoplasms / chemistry. Proto-Oncogene Proteins c-kit / analysis
  • [MeSH-minor] Aged. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Neoplasm Staging

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16015044.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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63. Song WJ, Yan LM, Zhao XL, Liu ZH, Sun BC: [Analysis of mitochondrial DNA D-loop region mutation and its significance in human oncocytoma]. Zhonghua Zhong Liu Za Zhi; 2010 Oct;32(10):767-70
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  • [Title] [Analysis of mitochondrial DNA D-loop region mutation and its significance in human oncocytoma].
  • OBJECTIVE: To investigate the mutation in mitochondrial DNA displacement-loop (mtDNA D-loop) region in oncocytoma and its relationship with tumorigenesis and tumor development.
  • METHODS: The mtDNA D-Loop region of 20 thyroid or renal oncocytomas and the adjacent normal tissues were amplified by PCR, and then sequenced.
  • RESULTS: Among the 20 oncocytomas, 21 mutations which focused on hypervariable region I (HVI) were found in 7 tumor tissues and 1 normal tissue with the mutation rates of 35% and 5%, respectively.
  • CONCLUSION: mtDNA D-loop region, especially HV I, is the mutational hotspot of oncocytomas, which may be closely related with mtDNA duplicating rate and the function of mitochondria.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. DNA, Mitochondrial / genetics. Kidney Neoplasms / genetics. Mutation. Thyroid Neoplasms / genetics

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  • (PMID = 21163068.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
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64. Yousef GM, Ejeckam GC, Best LM, Diamandis EP: Collecting duct carcinoma associated with oncocytoma. Int Braz J Urol; 2005 Sep-Oct;31(5):465-7; discussion 467-9
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  • [Title] Collecting duct carcinoma associated with oncocytoma.
  • Collecting duct carcinoma (CDC) is a rare, highly aggressive malignant neoplasm that arises from the collecting duct epithelium of the kidney.
  • CDC was reported to coexist with renal cell and transitional cell carcinomas.
  • We report a rare case of CDC associated with oncocytoma, confirmed by the characteristic histological appearance and immunohistochemistry.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Kidney Tubules, Collecting

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  • (PMID = 16255793.001).
  • [ISSN] 1677-5538
  • [Journal-full-title] International braz j urol : official journal of the Brazilian Society of Urology
  • [ISO-abbreviation] Int Braz J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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65. Eldahshan S, Celia A, Zeccolini G, Guerini A, Breda G: Laparoscopic transperitoneal adrenalectomy for adrenocortical oncocytoma. Arch Ital Urol Androl; 2008 Jun;80(2):82-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic transperitoneal adrenalectomy for adrenocortical oncocytoma.
  • Final pathology was adrenocortical oncocytoma with malignant potential.

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  • (PMID = 18683814.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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66. Modi P, Goel R, Kadam G: Retroperitoneoscopic partial adrenalectomy for large adrenocortical oncocytoma. J Endourol; 2007 Apr;21(4):419-22
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  • [Title] Retroperitoneoscopic partial adrenalectomy for large adrenocortical oncocytoma.
  • A young woman had mild hypertension, and on evaluation, a large tumor arising from the right adrenal gland was found.
  • The tumor was hormonally inactive.
  • The histopathology report described adrenocortical oncocytoma.

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  • (PMID = 17451335.001).
  • [ISSN] 0892-7790
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Vimentin
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67. Hes O, Michal M, Síma R, Vanecek T, Brunelli M, Martignoni G, Kuroda N, Cabrero IA, Perez-Montiel D, Hora M, Urge T, Dvorák M, Jarosová M, Yang X: Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical and genetic features. Virchows Arch; 2008 Mar;452(3):285-93
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  • [Title] Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical and genetic features.
  • We attempted to investigate the clinicopathological correlation of renal oncocytoma (RO) with renal vein extension.
  • After surgery, all patients were alive and free of tumors with follow-up of 1 to 5 years (mean=3.6).
  • Oncocytomas measured from 2.2 to 7.5 cm.
  • Tumor cells were positive for cytokeratins, mitochondrial antigen, epithelial membrane antigen, and parvalbumin; 5/7 tumors were focally positive for cluster of differentiation 117.
  • (1) renal oncocytomas may have intravascular extension to the branches of the renal vein;.
  • (2) renal oncocytomas with intravascular extension to the branches of the renal vein have the same morphological, immunohistochemical, and cytogenetic findings as have their counterparts without evidence of intravascular invasion;.
  • (3) the absence of metastases suggests an overall benign behavior of this tumor, but this has to be substantiated by further studies with a long-term follow-up;.
  • (4) in a renal tumor with granular cytoplasm showing renal vein extension, it is necessary to carefully exclude renal cell carcinomas (RCC) such as chromophobe RCC, oncocytic variant of papillary RCC, and granular variant of clear cell RCC.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers / analysis. Caenorhabditis elegans Proteins. Diagnosis, Differential. Female. Genome, Human. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Keratins / analysis. Loss of Heterozygosity. Male. Middle Aged. Mucin-1 / analysis. Mutation. Nucleic Acid Hybridization. Parvalbumins / analysis. Vacuolar Proton-Translocating ATPases. Von Hippel-Lindau Tumor Suppressor Protein / genetics

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  • (PMID = 18196270.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CAM 5.2 antigen; 0 / Caenorhabditis elegans Proteins; 0 / Mucin-1; 0 / Parvalbumins; 68238-35-7 / Keratins; EC 3.6.1.- / VHA-5 protein, C elegans; EC 3.6.1.- / Vacuolar Proton-Translocating ATPases; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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68. Feriozzi S, Giannakakis K, Ranalli TV, Pofi E, Gomes V, Ancarani E: Renal oncocytoma associated with necrotizing glomerulonephritis. Ren Fail; 2006;28(2):181-3
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  • [Title] Renal oncocytoma associated with necrotizing glomerulonephritis.
  • A case of renal oncocytoma associated with focal segmental necrotizing glomerulonephritis is described.
  • Our case is the first reported in which the removal of renal oncocytoma is not followed by the disappearance of renal symptoms, as currently reported in literature, suggesting that the two diseases are not always related.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Glomerulosclerosis, Focal Segmental / complications. Kidney Neoplasms / complications

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  • (PMID = 16538978.001).
  • [ISSN] 0886-022X
  • [Journal-full-title] Renal failure
  • [ISO-abbreviation] Ren Fail
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Shriki J, Murthy V, Brown J: Renal oncocytoma on 1-11C acetate positron emission tomography: Case report and literature review. Mol Imaging Biol; 2006 Jul-Aug;8(4):208-11
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  • [Title] Renal oncocytoma on 1-11C acetate positron emission tomography: Case report and literature review.
  • Renal oncocytomas are uncommon tumors of the renal collecting duct.
  • Although generally benign, these tumors pose a diagnostic and therapeutic dilemma in that they can not be differentiated noninvasively from renal cell carcinomas.
  • We report a 67-year-old man who underwent a clinical 1-11C acetate positron emission tomography (PET) scan for evaluation of possible metastatic prostate carcinoma.
  • Upon resection, this nodule was determined to be an oncocytoma.
  • To our knowledge, this marks the first report of the 1-11C acetate PET scan appearance of a renal oncocytoma Possible mechanisms for increased uptake include dysfunctional, but up-regulated oxidative phosphorylation or uptake through lipid biosynthesis pathways.
  • [MeSH-major] Adenoma, Oxyphilic / radionuclide imaging. Kidney Neoplasms / radionuclide imaging. Positron-Emission Tomography

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  • (PMID = 16791747.001).
  • [ISSN] 1536-1632
  • [Journal-full-title] Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
  • [ISO-abbreviation] Mol Imaging Biol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbon Radioisotopes
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70. Sokolova IA, Hes O, Michal M, Matsko DE: [Small-cell variant of renal oncocytoma]. Arkh Patol; 2007 Sep-Oct;69(5):34-6
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  • [Title] [Small-cell variant of renal oncocytoma].
  • Renal oncocytoma is a distinct benign tumor accounting for approximately 3-5% of all renal tumors.
  • This neoplasm is easily recognizable in its classic form: there are polygonal cells with abundant granular eosinophilic cytoplasm filled with mitochondria.
  • The tumor cells are arranged in nests and tubular pattern.
  • Here, 1 case of renal oncocytoma with a domination of small cells is reported (the so-called "oncoblasts") arising in elderly woman.
  • The term "small-cell variant of renal oncocytoma" was proposed for these cases.
  • The unusual extensive small-cell component of the tumor may represent a potential diagnostic pitfall for primary or metastatic malignant small cell tumors.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Small Cell / pathology. Cytoplasm / pathology. Kidney Neoplasms / pathology. Mitochondria / pathology
  • [MeSH-minor] Aged. Female. Humans. Neoplasm Metastasis

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  • (PMID = 18074818.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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71. Hes O, Michal M, Síma R, Vanecek T, Brunelli M, Martignoni G, Kuroda N, Alvarado Cabrero I, Perez-Montiel D, Hora M, Urge T, Dvorák M, Jarosová M, Yang X: Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical, and genetic features. Virchows Arch; 2008 Feb;452(2):193-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical, and genetic features.
  • We attempted to investigate the clinicopathological correlation of renal oncocytoma (RO) with renal vein extension.
  • After surgery, all patients were alive and free of tumors with follow-up of 1 to 5 years (mean = 3.6).
  • Oncocytomas measured from 2.2 to 7.5 cm.
  • Tumor cells were positive for cytokeratins, mitochondrial-antigen (MIA), epithelial membrane antigen (EMA), and parvalbumin; five of seven tumors were focally positive for CD117.
  • (1) renal oncocytomas may have intravascular extension to the branches of the renal vein;.
  • (2) renal oncocytomas with intravascular extension to the branches of the renal vein have the same morphological, immunohistochemical, and cytogenetic findings as have their counterparts without evidence of intravascular invasion;.
  • (3) the absence of metastases suggests an overall benign behavior of this tumor, but this has to be substantiated by further studies with a long-term follow-up; and (4) in a renal tumor with granular cytoplasm showing renal vein extension, it is necessary to carefully exclude renal cell carcinomas such as chromophobe RCC, oncocytic variant of papillary RCC, and granular variant of clear cell RCC.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology. Renal Veins / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Chromosome Aberrations. Cytoplasm / ultrastructure. DNA, Neoplasm / analysis. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Mitochondria / ultrastructure. Neoplasm Invasiveness. Nephrectomy

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  • (PMID = 18066590.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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72. Goel T, Thomas J, Garg S, Rao AC, Reddy S: Adrenal oncocytoma masquerading as a functional tumor. Indian J Urol; 2007 Jan;23(1):77-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal oncocytoma masquerading as a functional tumor.
  • Adrenal oncocytoma is a rare entity, with 20 cases reported in literature.
  • A functional oncocytoma is extremely rare.
  • We present a case of adrenal oncocytoma in a hypertensive male who had elevated catecholamine levels, which improved after adrenalectomy with decrease in daily antihypertensive requirement.

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  • [Cites] Indian J Pathol Microbiol. 2004 Jul;47(3):387-9 [16295431.001]
  • [Cites] Ann Diagn Pathol. 2005 Oct;9(5):295-7 [16198960.001]
  • [Cites] J Clin Pathol. 1999 Feb;52(2):151-3 [10396247.001]
  • [Cites] Urology. 1997 Apr;49(4):624-8 [9111640.001]
  • [Cites] Pathol Annu. 1992;27 Pt 1:263-304 [1736246.001]
  • [Cites] Am J Clin Pathol. 1992 Jan;97(1):73-83 [1728867.001]
  • [Cites] Arch Pathol Lab Med. 2002 Feb;126(2):170-2 [11825112.001]
  • (PMID = 19675771.001).
  • [ISSN] 0970-1591
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2721505
  • [Keywords] NOTNLM ; Adrenal oncocytoma / adrenalectomy / catecholamines / immunostaining
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73. Al-Saleem T, Balsara BR, Liu Z, Feder M, Testa JR, Wu H, Greenberg RE: Renal oncocytoma with loss of chromosomes Y and 1 evolving to papillary carcinoma in connection with gain of chromosome 7. Coincidence or progression? Cancer Genet Cytogenet; 2005 Nov;163(1):81-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal oncocytoma with loss of chromosomes Y and 1 evolving to papillary carcinoma in connection with gain of chromosome 7. Coincidence or progression?
  • Hybrid tumors of the kidney are not rare.
  • Previous studies of hybrid renal tumors have been valuable for the understanding of the pathogenesis and progression pathways of renal cell neoplasm.
  • In this paper we describe the morphologic, immunohistochemical, and genetic features of 2 oncocytomas with evolving papillary renal cell carcinoma (PRCC) in a nephrectomy specimen of a 60-year old male.
  • The patient was referred for urologic oncology consultation after the incidental discovery of a renal tumor.
  • The tumors were stained with hematoxylin and eosin, cytokeratin 7 and vimentin.
  • Morphologically, both tumors were oncocytomas with numerous microscopic papillary nests and psammoma bodies.
  • Papillary carcinoma nests were highlighted with cytokeratin 7 and vimentin positivity and were more prominent in the larger tumor.
  • We postulate that the PRCC represents a neoplastic progression by the gain of chromosome 7 oncocytoma with -Y and -1.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Papillary / genetics. Chromosome Aberrations. Chromosome Deletion. Chromosomes, Human, Pair 7. Chromosomes, Human, Y. Kidney Neoplasms / genetics

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  • (PMID = 16271962.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Stomeo F, Meloni F, Bozzo C, Fois V, Pastore A: Bilateral oncocytoma of the parotid gland. Acta Otolaryngol; 2006 Mar;126(3):324-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral oncocytoma of the parotid gland.
  • Oncocytic neoplasms are a group of rare tumours that mostly affect the parotid gland (80%), sometimes affect the submandibular gland (9%) and rarely affect the intraoral minor salivary glands.
  • The incidence of oncocytic neoplasms represents approximately 1% of parotid neoplasms and bilateral presentation is very rare.
  • Herein we describe a single case involving bilateral presentation of oncocytoma of the parotid glands.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / surgery. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery

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  • (PMID = 16618664.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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75. Widziszowska A, Namysłowski G, Hajduk A, Lange D: [Parapharyngeal oncocytoma of the parotid gland--case report]. Otolaryngol Pol; 2007;61(2):195-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Parapharyngeal oncocytoma of the parotid gland--case report].
  • Oncocytoma is a rare, benign salivary gland tumour with slowly course.
  • It usually occurs in the parotid gland, seldom in submandibular gland.
  • This report presents a case of parapharyngeal oncocytoma of the left parotid gland in 77-year-old patient, treated in 2nd ENT Department of Medical University of Silesia in Zabrze.
  • On the basis of physical examination and preoperative radiologic studies (computed tomography scan of nasopharynx, magnetic resonance imaging, Doppler ultrasonography of carotid and vertebral arteries) the extensiveness of the tumour was determined and the surgical procedure was undertaken.
  • The removal of a whole tumour was performed through a cervical--transpharyngeal approach with midline mandibulotomy.
  • A follow-up of 30 months hasn't revealed any recurrence of the oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / surgery. Parotid Neoplasms / diagnosis. Parotid Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Magnetic Resonance Imaging. Parotid Gland / radiography. Parotid Gland / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17668810.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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76. Brunelli M, Eble JN, Zhang S, Martignoni G, Delahunt B, Cheng L: Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma. Mod Pathol; 2005 Feb;18(2):161-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma.
  • That chromophobe renal cell carcinoma has an uncommon eosinophilic variant has been recognized for more than a decade.
  • In sections stained with hematoxylin and eosin, the eosinophilic variant of chromophobe renal cell carcinoma and renal oncocytoma are similar in appearance.
  • While it is well established that chromophobe renal cell carcinoma and renal oncocytoma have different patterns of genetic anomalies, little is known of the genetics of the eosinophilic variant of chromophobe renal cell carcinoma.
  • This study was undertaken to elucidate the genetic lesions of eosinophilic chromophobe renal cell carcinoma and to compare them with those found in classic chromophobe renal cell carcinoma and in renal oncocytoma.
  • A total of 29 renal neoplasms--nine eosinophilic chromophobe renal cell carcinomas, 10 classic chromophobe renal cell carcinomas, and 10 oncocytomas--were investigated by fluorescence in situ hybridization on 5 microm paraffin-embedded tissue sections with centromeric probes for chromosomes 1, 2, 6, 10, and 17.
  • Signals were counted in 100-200 neoplastic nuclei from each tumor.
  • Chromophobe renal cell carcinomas frequently showed loss of chromosomes 1 (70% of classic, 67% of eosinophilic), 2 (90% classic, 56% eosinophilic), 6 (80% classic, 56% eosinophilic), 10 (60% classic, 44% eosinophilic), and 17 (90% classic, 78% eosinophilic); Among the classic chromophobe renal cell carcinomas, only one had no loss of any of the chromosomes, while 50% had loss of all five chromosomes.
  • Among the eosinophilic chromophobe renal cell carcinomas, one of nine had no loss and 44% had loss of all five chromosomes.
  • One oncocytoma had loss of chromosome 1.
  • No other chromosomal loss was detected in the oncocytomas.
  • In conclusion, losses of chromosomes 1, 2, 6, 10, and 17 are frequent in both eosinophilic and classic chromophobe renal cell carcinomas.
  • Loss of chromosome 1 occurs occasionally in oncocytoma but losses of chromosomes 2, 6, 10, and 17 are not found in oncocytomas.
  • When the differential diagnostic problem is oncocytoma vs eosinophilic chromophobe renal cell carcinoma, detection of losses of chromosomes 2, 6, 10, or 17 effectively excludes the diagnosis of oncocytoma and supports the diagnosis of chromophobe renal cell carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Chromosome Aberrations. Kidney Neoplasms / pathology

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  • (PMID = 15467713.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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77. Choudhary S, Rajesh A, Mayer NJ, Mulcahy KA, Haroon A: Renal oncocytoma: CT features cannot reliably distinguish oncocytoma from other renal neoplasms. Clin Radiol; 2009 May;64(5):517-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal oncocytoma: CT features cannot reliably distinguish oncocytoma from other renal neoplasms.
  • AIM: To retrospectively review the computed tomography (CT) imaging features of a series of histologically confirmed renal oncocytomas and to determine whether imaging features are predictive of this subtype of benign renal epithelial tumour.
  • MATERIALS AND METHODS: From May 2001 to October 2007, 21 patients with 28 renal masses, confirmed as renal oncocytoma on histological examination of the resection specimen, were identified from the pathology database at our institution.
  • The preoperative imaging findings were retrospectively analysed to determine characteristic features, if any, to predict this rare subtype of benign renal tumour.
  • In 18 (64.3%) lesions the enhancement of the tumour was isodense to renal cortex.
  • CONCLUSION: Renal oncocytoma is typically described as being hypervascular and homogeneous, with a characteristic central stellate scar on CT.
  • The present study demonstrates that these imaging features are found in only a small proportion of these tumours.
  • Therefore, imaging characteristics alone are unreliable when differentiating between oncocytoma and renal cell carcinoma, and histopathological diagnosis remains the reference standard.
  • [MeSH-major] Adenoma, Oxyphilic / radiography. Kidney Neoplasms / radiography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Tomography, Spiral Computed / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19348848.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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78. Lee SS, Baek KH, Lee YS, Lee JM, Kang MI, Cha BY, Lee KW, Son HY, Kang SK: Subclinical Cushing's syndrome associated with an adrenocortical oncocytoma. J Endocrinol Invest; 2008 Jul;31(7):675-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subclinical Cushing's syndrome associated with an adrenocortical oncocytoma.
  • Oncocytoma is a neoplasm that can arise in several organs, and it has been more commonly described in the kidney, salivary gland and thyroid.
  • Oncocytoma arising in the adrenal gland is a rare finding.
  • Moreover, functioning adrenocortical oncocytoma is exceptionally rare.
  • Right adrenalectomy was performed, and this revealed a well-circumscribed dark-brown tumor that measured 2.4x2.2 cm.
  • The tumor consisted almost exclusively of large eosinophilic and epitheloid cells whose cytoplasm was packed with eosinophilic granulations, which corresponded to the numerous mitochondria confirmed on electron microscopy.
  • This is a rare case of subclinical Cushing's syndrome that was caused by adrenocortical oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenal Cortex Neoplasms / pathology. Cushing Syndrome / pathology

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  • (PMID = 18787391.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Synaptophysin; 0 / inhibin A; 57285-09-3 / Inhibins; 68238-35-7 / Keratins; 7S5I7G3JQL / Dexamethasone
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79. Juliano JJ, Cody RL, Suh JH: Metastatic adrenocortical oncocytoma: a case report. Urol Oncol; 2008 Mar-Apr;26(2):198-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adrenocortical oncocytoma: a case report.
  • With only 51 cases reported in the literature to date, adrenocortical oncocytoma is an exceedingly rare pathological variant of adrenal neoplasms.
  • The first case of metastatic adrenocortical oncocytoma is reported along with an update of the literature.
  • [MeSH-major] Adenoma, Oxyphilic / secondary. Adrenal Cortex Neoplasms / pathology. Femoral Neoplasms / secondary

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  • (PMID = 18312941.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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80. Kurli M, Finger PT, Garcia JP Jr, Schneider S: Peribulbar oncocytoma: high-frequency ultrasound with histopathologic correlation. Ophthalmic Surg Lasers Imaging; 2006 Mar-Apr;37(2):154-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peribulbar oncocytoma: high-frequency ultrasound with histopathologic correlation.
  • The clinical, ultrasonographic, and histopathologic characteristics of an oncocytoma of the conjunctiva are described.
  • A clinical examination including high-frequency ultrasound was performed prior to excisional biopsy of her tumor.
  • High-frequency ultrasound demonstrated an epibulbar tumor with low internal reflectivity and a cystic component.
  • Multiple hypoechoic components of the tumor stroma were correlated to multiple cystic glandular structures on histopathologic evaluation.
  • The excised tumor was diagnosed to be an oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / ultrasonography. Conjunctival Neoplasms / pathology. Conjunctival Neoplasms / ultrasonography

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  • (PMID = 16583640.001).
  • [ISSN] 1542-8877
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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81. Jayaratna I, Munver R, Disick G, Han MW, Sawczuk I: Paraneoplastic hypertension associated with renal oncocytoma: management with cryoablation. Urology; 2009 Jan;73(1):209.e9-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraneoplastic hypertension associated with renal oncocytoma: management with cryoablation.
  • Paraneoplastic hypertension associated with a renal oncocytoma is an unreported syndrome.
  • Histologic review of intraoperative biopsy specimens revealed findings consistent with renal oncocytoma.
  • To our knowledge, this is the first report of hypertension in the setting of a renal oncocytoma, with subsequent improvement of this paraneoplastic syndrome after cryoablation.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Adenoma, Oxyphilic / surgery. Cryosurgery. Hypertension / etiology. Hypertension / surgery. Kidney Neoplasms / complications. Kidney Neoplasms / surgery. Paraneoplastic Syndromes / etiology. Paraneoplastic Syndromes / surgery

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  • (PMID = 18372030.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Siriweera EH, Ratnatunga NV: Profile of Hashimoto's Thyroiditis in Sri Lankans: Is There an Increased Risk of Ancillary Pathologies in Hashimoto's Thyroiditis? J Thyroid Res; 2010;2010:124264

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hashimoto's thyroiditis has been reported to be associated with many neoplastic and nonneoplastic thyroid pathologies.
  • This retrospective study aims to determine the demographic profile of Hashimoto's thyroiditis in Sri Lankans, document ancillary pathologies in Hashimoto's thyroiditis, and determine whether there is an increased risk of occurrence of malignancies, benign neoplasms, and nonneoplastic benign lesions in Hashimoto's thyroiditis by comparing with thyroids showing multinodular goiters, follicular adenomas, and colloid nodules.
  • This study revealed a statistically significant increase of thyroid malignancies in association with Hashimoto's thyroiditis.
  • The association of Papillary carcinoma, Non-Hodgkin's lymphoma, and Hurthle cell adenoma with Hashimoto's thyroiditis was statistically significant.

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  • (PMID = 21048834.001).
  • [ISSN] 2042-0072
  • [Journal-full-title] Journal of thyroid research
  • [ISO-abbreviation] J Thyroid Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2955451
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83. Adhikari P, Pradhananga RB, Sinha BK, Pradhan B, Thapa N: Oncocytoma of maxillary sinus--a rare presentation. Nepal Med Coll J; 2006 Dec;8(4):292-3

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  • [Title] Oncocytoma of maxillary sinus--a rare presentation.
  • A case of Oncocytoma of maxillary sinus in a 73 years old female is reported along with a brief review of literature.
  • To the best of our knowledge this extremely rare tumor is the first of its kind reported in Nepal.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Maxillary Sinus Neoplasms / pathology

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  • (PMID = 17357654.001).
  • [Journal-full-title] Nepal Medical College journal : NMCJ
  • [ISO-abbreviation] Nepal Med Coll J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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84. Sharma N, Dogra PN, Mathur S: Functional adrenal oncocytoma: a rare neoplasm. Indian J Pathol Microbiol; 2008 Oct-Dec;51(4):531-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional adrenal oncocytoma: a rare neoplasm.
  • Adrenal oncocytoma is a rare adrenal neoplasm with only 21 cases reported in English literature.
  • These adrenal tumors are usually nonfunctional and hence incidentally detected.
  • Most of these adrenal neoplasms are benign.
  • We report a rare case of adrenal oncocytoma that was functional and was successfully managed by laparoscopic adrenalectomy.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenal Gland Neoplasms / pathology

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  • (PMID = 19008586.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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85. Rosenkrantz AB, Hindman N, Fitzgerald EF, Niver BE, Melamed J, Babb JS: MRI features of renal oncocytoma and chromophobe renal cell carcinoma. AJR Am J Roentgenol; 2010 Dec;195(6):W421-7
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  • [Title] MRI features of renal oncocytoma and chromophobe renal cell carcinoma.
  • OBJECTIVE: The purpose of this study was to retrospectively describe the MRI features of the pathologically related entities renal oncocytoma and chromophobe renal cell carcinoma (RCC).
  • MATERIALS AND METHODS: Twenty-eight cases of histologically proven renal oncocytoma and 15 of chromophobe RCC evaluated with preoperative MRI from January 2003 through June 2009 at our institution were independently reviewed for an array of MRI features by two radiologists blinded to the final histopathologic diagnosis.
  • These features were tabulated and compared between chromophobe RCC and renal oncocytoma by use of the Mann-Whitney test and binary logistic regression.
  • RESULTS: Renal oncocytoma and chromophobe RCC showed no significant difference in size or any of 16 qualitative imaging features (p = 0.0842-1.0, reader 1; p = 0.0611-1.0, reader 2).
  • A central scar and segmental enhancement inversion (a recently described finding in which early contrast-enhanced images show relatively more enhanced and less enhanced intralesional components with inversion of their relative enhancement on later images) were observed by both readers in at least 10% of cases of both renal oncocytoma and of chromophobe RCC with no significant difference between the two entities (p = 0.2092-0.2960).
  • CONCLUSION: We have presented the largest series to date of the MRI features of both renal oncocytoma and chromophobe RCC.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Magnetic Resonance Imaging / methods


86. Gumy-Pause F, Bongiovanni M, Wildhaber B, Jenkins JJ, Chardot C, Ozsahin H: Adrenocortical oncocytoma in a child. Pediatr Blood Cancer; 2008 Mar;50(3):718-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenocortical oncocytoma in a child.
  • Adrenocortical oncocytoma is a rare epithelial tumor only described in adults.
  • A diagnosis of adrenocortical oncocytoma was made after detailed histological, immunohistochemical, and ultrastructural studies.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenal Cortex Neoplasms / pathology
  • [MeSH-minor] Acne Vulgaris / etiology. Adrenalectomy. Androstenedione / secretion. Child. Female. Humans. Neoplasm Proteins / analysis. Testosterone / secretion

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17091483.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 3XMK78S47O / Testosterone; 409J2J96VR / Androstenedione
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87. Tan MH, Wong CF, Tan HL, Yang XJ, Ditlev J, Matsuda D, Khoo SK, Sugimura J, Fujioka T, Furge KA, Kort E, Giraud S, Ferlicot S, Vielh P, Amsellem-Ouazana D, Debré B, Flam T, Thiounn N, Zerbib M, Benoît G, Droupy S, Molinié V, Vieillefond A, Tan PH, Richard S, Teh BT: Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma. BMC Cancer; 2010;10:196
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma.
  • BACKGROUND: Chromophobe renal cell carcinoma (chRCC) and renal oncocytoma are two distinct but closely related entities with strong morphologic and genetic similarities.
  • While chRCC is a malignant tumor, oncocytoma is usually regarded as a benign entity.
  • The overlapping characteristics are best explained by a common cellular origin, and the biologic differences between chRCC and oncocytoma are therefore of considerable interest in terms of carcinogenesis, diagnosis and clinical management.
  • Previous studies have been relatively limited in terms of examining the differences between oncocytoma and chromophobe RCC.
  • METHODS: Gene expression profiling using the Affymetrix HGU133Plus2 platform was applied on chRCC (n = 15) and oncocytoma specimens (n = 15).
  • Immunohistochemical validation was performed in an independent set of tumors.
  • RESULTS: A novel 14 probe-set signature was developed to classify the tumors internally with 93% accuracy, and this was successfully validated on an external data-set with 94% accuracy.
  • CONCLUSIONS: Gene expression profiles, high-throughput SNP genotyping, and pathway analysis effectively distinguish chRCC from oncocytoma.
  • A cytogenetic alteration, loss of chromosome 1p, common to renal oncocytoma and chRCC has been identified, providing the opportunities for identifying novel tumor suppressor genes and we have identified a series of immunohistochemical markers that are clinically useful in discriminating chRCC and oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Biomarkers, Tumor / genetics. Carcinoma, Renal Cell / genetics. Chromosomes, Human, Pair 1. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Genetic Testing / methods. Kidney Neoplasms / genetics. Polymorphism, Single Nucleotide
  • [MeSH-minor] Aquaporin 6 / analysis. Cytogenetic Analysis. Diagnosis, Differential. Gene Dosage. Gene Regulatory Networks. Humans. Immunohistochemistry. Membrane Proteins / analysis. Nerve Tissue Proteins / analysis. Odds Ratio. Oligonucleotide Array Sequence Analysis. Predictive Value of Tests. Reproducibility of Results. Synaptogyrins. Tumor Suppressor Proteins / analysis


88. Lee R, Al-Ahmadie HA, Boorjian SA, Gonzalez RR, Badillo C, Badillo F, Reuter VE, Steckel J: A case of incidental adrenocortical oncocytoma. Nat Clin Pract Urol; 2006 Nov;3(11):618-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of incidental adrenocortical oncocytoma.
  • DIAGNOSIS: Oncocytic adrenocortical tumor, or adrenal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / surgery. Adrenal Cortex Neoplasms / diagnosis. Adrenal Cortex Neoplasms / surgery

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  • (PMID = 17088930.001).
  • [ISSN] 1743-4289
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Peppa M, Karamitopoulou E, Nikolopoulos P, Peros G, Economopoulos T, Raptis SA, Hadjidakis D: Large adrenal oncocytoma with uncertain malignant potential: case report and review of literature. Endocr Pract; 2010 Jul-Aug;16(4):641-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large adrenal oncocytoma with uncertain malignant potential: case report and review of literature.
  • OBJECTIVE: To report a case of oncocytoma, a relatively rare adrenal tumor, which most commonly is detected as an adrenal incidentaloma.
  • RESULTS: On the basis of the hormonal evaluation, this mass was a nonsecreting adrenal tumor, which histologically proved to be an oncocytoma with borderline malignant characteristics.
  • A collective analysis of the few cases of adrenal oncocytoma published in the medical literature showed that our case corresponded to the previously published cases in preponderant location (left side) as well as the general size (11.4 cm in the largest dimension) and weight (372 g).
  • CONCLUSION: Adrenal oncocytoma should be included in the differential diagnosis of adrenal incidentalomas, especially if large tumors are detected.
  • In addition, a longterm follow-up is suggested because there are no certain clues about the true potential of this tumor.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adrenal Gland Neoplasms / diagnosis. Precancerous Conditions / diagnosis
  • [MeSH-minor] Adrenocortical Adenoma / complications. Adrenocortical Adenoma / diagnosis. Adrenocortical Adenoma / pathology. Diagnosis, Differential. Female. Humans. Hypertension / complications. Incidental Findings. Magnetic Resonance Imaging. Middle Aged. Obesity / complications. Tomography, X-Ray Computed

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  • (PMID = 20061289.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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90. Geramizadeh B, Norouzzadeh B, Bolandparvaz S, Sefidbakht S: Functioning adrenocortical oncocytoma: a case report and review of literature. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):237-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functioning adrenocortical oncocytoma: a case report and review of literature.
  • Adrenocortical oncocytoma is very rare.
  • We herein report a case of functioning adrenocortical oncocytoma of the left adrenal cortex in a young woman.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adrenal Cortex Neoplasms / diagnosis

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  • (PMID = 18603692.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Synaptophysin; 0 / Vimentin
  • [Number-of-references] 8
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91. Subramaniam RM, Durnick DK, Peller PJ: F-18 FDG PET/CT imaging of submandibular gland oncocytoma. Clin Nucl Med; 2008 Jul;33(7):472-4
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  • [Title] F-18 FDG PET/CT imaging of submandibular gland oncocytoma.
  • F-18 FDG PET/CT is used to evaluate head and neck malignancies, including salivary gland tumors.
  • We describe the FDG PET/CT features of a submandibular gland oncocytoma.
  • An 85-year-old patient with small cell cancer of the lung and a history of squamous cell carcinoma of the lower lip was evaluated with FDG PET/CT.
  • There was an intensely hypermetabolic left submandibular gland lesion that was suspected for a metastasis.
  • Ultrasound-guided fine needle aspirate of the lesion proved to be a submandibular gland oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / radionuclide imaging. Fluorodeoxyglucose F18. Positron-Emission Tomography / methods. Radiopharmaceuticals. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / radionuclide imaging. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Aged, 80 and over. Biopsy, Fine-Needle. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / pathology. Humans. Lip Neoplasms / complications. Lip Neoplasms / pathology. Lung Neoplasms / complications. Lung Neoplasms / pathology. Male. Neoplasm Metastasis. Neoplasm Staging / methods

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  • (PMID = 18580232.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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92. Neuzillet Y, Lechevallier E, André M, de Fromont M, Nahon O, Coulange C: [Renal oncocytoma associated with renal cell carcinoma]. Prog Urol; 2005 Apr;15(2):312-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Renal oncocytoma associated with renal cell carcinoma].
  • [Transliterated title] Adénome oncocytaire rénal associé à un carcinome à cellules rénales chromophobes.
  • Renal oncocytoma is a benign tumour that can be associated with renal cell carcinoma in rare genetic syndromes.
  • The authors report the case of a 62-year-old patient with no medical history, in whom assessment of low back pain in 1999 demonstrated a 40 mm tumour of the lower pole of the left kidney.
  • Percutaneous needle biopsy of the tumour demonstrated oncocytoma confirmed by Hale's stain.
  • Surgery was indicated in view of the rapid increase of the tumour volume.
  • Histological examination of the operative specimen demonstrated a combination of oncocytoma and Fuhrman grade III renal cell carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis

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  • (PMID = 15999615.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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93. Bouasker I, Zoghlami A, Farah Klibi F, Smaali I, El Ouaer MA, Zermani R, Dziri C: Adreno-cortical oncocytoma: a case report. Tunis Med; 2010 May;88(5):353-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adreno-cortical oncocytoma: a case report.
  • BACKGROUND: Adrenal oncocytoma is a very rare lesion, non functioning and benignin most cases.
  • AIM: This study aimed to report a new case of adrenal oncocytic tumor with uncertain malignant potential.
  • Ultrasonography and omputed tomography scan revealed a large mass in the right adrenal gland with extension to the right kidney.
  • The diagnosis of adrenal oncocytoma with malignant potential was confirmed by pathology.
  • He was followed up for 8 months, no tumor recurrence detected.
  • CONCLUSION: Adreno cortical oncocytoma is a rare tumor.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenal Gland Neoplasms / pathology. Kidney Cortex / pathology. Kidney Neoplasms / pathology

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  • (PMID = 20517834.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Tunisia
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94. Dasanu CA, Alexandrescu DT: Bilateral perinephric diffuse large B-cell lymphoma and synchronous renal oncocytoma. South Med J; 2008 Feb;101(2):196-8
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  • [Title] Bilateral perinephric diffuse large B-cell lymphoma and synchronous renal oncocytoma.
  • An elderly patient who presented with bilateral perinephric diffuse large B-cell lymphoma and concomitant oncocytoma of the same location is reported.
  • To our knowledge, the anatomic proximity of the two tumors at the level of kidneys has not been previously described.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 18364624.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Theodosopoulos T, Yiallourou A, Kyriazi M, Anastasopoulos G, Kairi-Vassilatou E, Dafnios N, Vassiliou I: Unilateral simultaneous renal oncocytoma and angiomyolipoma: case report. Cases J; 2009;2:9093

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  • [Title] Unilateral simultaneous renal oncocytoma and angiomyolipoma: case report.
  • A rare case of synchronous angiomyolipoma and oncocytoma in the same kidney of a 70 year old man is presented.
  • A working diagnosis of renal cell carcinoma was made.
  • Microscopically, the tumor of the lower pole was found to be an angiomyolipoma, whereas the mid-portion tumor was an oncocytoma.
  • Until now, only 16 cases of unilateral simultaneous presence of renal angiomyolipoma and oncocytoma have been reported.
  • It is well worth remarking, that renal oncocytoma overlap with other renal neoplasms, therefore nephrectomy remains the treatment of choice.Renal angiomyolipoma and oncocytoma are uncommon neoplasms and their simultaneous presence in the same kidney is rare.

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  • (PMID = 20062730.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803890
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96. Akatsu T, Kameyama K, Araki K, Ashizawa T, Wakabayashi G, Kitajima M: Functioning adrenocortical oncocytoma: the first documented case producing interleukin-6 and review of the literature. J Endocrinol Invest; 2008 Jan;31(1):68-73
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  • [Title] Functioning adrenocortical oncocytoma: the first documented case producing interleukin-6 and review of the literature.
  • Adrenocortical oncocytoma is an extremely rare and predominantly non-functioning tumor.
  • We herein report the first case of an adrenocortical oncocytoma that produces interleukin (IL)-6.
  • Microscopic examination showed that the tumor was an adrenocortical oncocytoma with a unique peripheral lymphoid cuff with germinal centers.
  • Three observations lead us to consider that this tumor was the primary source of serum IL-6.
  • [MeSH-major] Adenoma, Oxyphilic / secretion. Adrenal Cortex Neoplasms / secretion. Interleukin-6 / secretion

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  • (PMID = 18296908.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Interleukin-6
  • [Number-of-references] 43
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97. Fan YH, Chang YH, Huang WJ, Chung HJ, Chen KK: Renal oncocytoma: clinical experience of Taipei Veterans General Hospital. J Chin Med Assoc; 2008 May;71(5):254-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal oncocytoma: clinical experience of Taipei Veterans General Hospital.
  • BACKGROUND: Renal oncocytoma has been reported mostly in the Western literature, and only a few cases have been reported in Eastern populations.
  • In the present study, we review the clinical course of renal oncocytoma in our institution.
  • METHODS: We obtained the files of 13 cases of renal oncocytoma between 1988 and 2006 from the pathological archives of Taipei Veterans General Hospital.
  • Twelve patients (92%) were asymptomatic at presentation and were incidentally diagnosed to have renal tumor by sonography (9 patients), computed tomography (1 patient) or magnetic resonance imaging (2 patients), and 1 presented with hematuria.
  • The clinical impression of oncocytoma was made preoperatively in only 3 patients by imaging studies, and most of the patients (76.9%) were diagnosed with renal cell carcinoma before surgery.
  • All patients had unilateral solitary renal tumor; the right kidney was involved in 7 cases (54%) and the left in 6 (46%).
  • Mean tumor size was 5.3 cm (range, 2.7-8.5 cm).
  • CONCLUSION: Renal oncocytoma has a benign clinical course with excellent long-term outcomes.
  • Currently, nephron-sparing surgery is the mainstay of treatment, especially in patients with small tumors.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Carcinoma, Renal Cell / diagnosis. Female. Humans. Male. Middle Aged. Nephrectomy. Positron-Emission Tomography. Retrospective Studies

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  • (PMID = 18490230.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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98. Koeman JM, Russell RC, Tan MH, Petillo D, Westphal M, Koelzer K, Metcalf JL, Zhang Z, Matsuda D, Dykema KJ, Houseman HL, Kort EJ, Furge LL, Kahnoski RJ, Richard S, Vieillefond A, Swiatek PJ, Teh BT, Ohh M, Furge KA: Somatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated EGLN2-mediated [corrected] oxygen-sensing response. PLoS Genet; 2008 Sep 05;4(9):e1000176
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Somatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated EGLN2-mediated [corrected] oxygen-sensing response.
  • Gene expression profiling studies revealed that somatic pairing of chromosome 19 is a recurrent chromosomal abnormality in renal oncocytoma, a neoplasia of the adult kidney.
  • Overexpression of EGLN2 [corrected] in renal oncocytoma increased ubiquitin-mediated destruction of HIF and concomitantly suppressed the expression of several HIF-target genes, including the pro-death BNIP3L gene.
  • The identification of EGLN2 as a significantly deregulated gene that maps within the paired chromosome region directly implicates defects in the oxygen-sensing network to the biology of renal oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / metabolism. Chromosome Pairing / genetics. Chromosomes, Human, Pair 19. Dioxygenases / genetics. Kidney Neoplasms / genetics. Kidney Neoplasms / metabolism. Nuclear Proteins / genetics. Oxygen / metabolism. Procollagen-Proline Dioxygenase / genetics
  • [MeSH-minor] Carcinoma, Renal Cell / genetics. Carcinoma, Renal Cell / metabolism. Cell Hypoxia / genetics. Cell Line, Tumor. Down-Regulation. Gene Expression Profiling. Humans. Hypoxia-Inducible Factor 1 / genetics. Hypoxia-Inducible Factor 1 / metabolism. Hypoxia-Inducible Factor-Proline Dioxygenases

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  • [ErratumIn] PLoS Genet. 2008 Jul;4(7). doi: 10.1371/annotation/7f57058f-cc02-45a6-bfab-a835619e3916
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  • (PMID = 18773095.001).
  • [ISSN] 1553-7404
  • [Journal-full-title] PLoS genetics
  • [ISO-abbreviation] PLoS Genet.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R33-CA10113-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypoxia-Inducible Factor 1; 0 / Nuclear Proteins; EC 1.13.11.- / Dioxygenases; EC 1.14.11.2 / Procollagen-Proline Dioxygenase; EC 1.14.11.29 / EGLN2 protein, human; EC 1.14.11.29 / Hypoxia-Inducible Factor-Proline Dioxygenases; S88TT14065 / Oxygen
  • [Other-IDs] NLM/ PMC2518213
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99. Brocks BA, Peeters ME, Kimpfler S: Oncocytoma in the mandibular salivary gland of a cat. J Feline Med Surg; 2008 Apr;10(2):188-91
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  • [Title] Oncocytoma in the mandibular salivary gland of a cat.
  • Initial investigations suggested a malignant salivary gland tumour, and the mass was removed by extracapsular resection of the mandibular gland.
  • Histopathology showed an oncocytoma within the salivary gland.
  • An oncocytoma is a neoplastic transformation of oncocytes.
  • Physiological proliferation occurs next to oncocytosis, oncocytoma, and oncocytic carcinoma.
  • This is the first report of an oncocytoma in a feline mandibular salivary gland, and the first report of long-term survival after surgical removal.
  • [MeSH-major] Adenoma, Oxyphilic / veterinary. Cat Diseases / diagnosis. Salivary Gland Neoplasms / veterinary

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  • (PMID = 18160323.001).
  • [ISSN] 1098-612X
  • [Journal-full-title] Journal of feline medicine and surgery
  • [ISO-abbreviation] J. Feline Med. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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100. Xiao GQ, Pertsemlidis DS, Unger PD: Functioning adrenocortical oncocytoma: a case report and review of the literature. Ann Diagn Pathol; 2005 Oct;9(5):295-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functioning adrenocortical oncocytoma: a case report and review of the literature.
  • Adrenocortical oncocytoma is exceptionally rare.
  • Most of these tumors are benign and nonfunctioning.
  • We report a case of functioning adrenocortical oncocytoma located in the right adrenal gland in a 53-year-old woman who presented with Cushing's syndrome.
  • The tumor was small, with exclusively oncocytic histologic features.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenal Cortex Neoplasms / pathology

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  • (PMID = 16198960.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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