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1. Chave G, Milot L, Pilleul F: [Out of phase magnetic resonance imaging and liver applications]. J Radiol; 2005 Sep;86(9 Pt 1):993-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Out of phase magnetic resonance imaging and liver applications].
  • [Transliterated title] Imagerie par résonance magnétique en opposition de phase et ses applications hépatiques.
  • The increasing indications for MRI evaluation of diseases of the abdomen, especially liver tumors, has promoted the development of sequences allowing further histological characterization.
  • Available on all MR imagers, it is the most sensitive sequence to depict small amounts of lipids in the liver.
  • Best applications of this sequence include liver steatosis, tumoral characterization with regards to lipid content (adenoma, hepatocellular carcinoma...) and depiction of tumors in abnormal liver.
  • Performed without contrast injection, and using fast imaging acquisition, we believe that out of phase imaging should be performed for magnetic resonance imaging of the liver.
  • [MeSH-major] Image Enhancement / methods. Liver Diseases / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Fatty Liver / diagnosis. Humans. Lipids / analysis. Liver Neoplasms / diagnosis

  • MedlinePlus Health Information. consumer health - Liver Diseases.
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  • (PMID = 16224338.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Lipids
  • [Number-of-references] 19
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2. Venturi A, Piscaglia F, Vidili G, Flori S, Righini R, Golfieri R, Bolondi L: Diagnosis and management of hepatic focal nodular hyperplasia. J Ultrasound; 2007 Sep;10(3):116-27

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and management of hepatic focal nodular hyperplasia.
  • Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver, after hemangioma.
  • The main clinical task is to differentiate it from other hypervascular hepatic lesions such as hepatic adenoma, hepatocellular carcinoma, or hypervascular metastases, but invasive diagnostic procedures can generally be avoided with the appropriate use of imaging techniques.
  • Magnetic resonance (MR) imaging is more sensitive and specific than conventional ultrasonography (US) or computed tomography (CT), but Doppler US and contrast-enhanced US (CEUS) can greatly improve the accuracy in the diagnosis of FNH.
  • Once a correct diagnosis has been made, in most cases there is no indication for surgery, and treatment includes conservative clinical follow-up in asymptomatic patients.

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  • (PMID = 23396642.001).
  • [ISSN] 1971-3495
  • [Journal-full-title] Journal of ultrasound
  • [ISO-abbreviation] J Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3478711
  • [Keywords] NOTNLM ; Contrast-enhanced ultrasonography / Diagnosis / Focal nodular hyperplasia / Management / Ultrasonology
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3. Wang L, Camus AC, Dong W, Thornton C, Willett KL: Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis. Aquat Toxicol; 2010 Sep 15;99(4):439-47
Hazardous Substances Data Bank. DIMETHYL SULFOXIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Immunohistochemistry (IHC) results from fry revealed strongest CYP1C1 expression in renal tubular and intestinal epithelial cells.
  • Additional fish were examined for liver lesions 8 months after initial exposure.
  • Histopathologic findings included foci of cellular alteration and neoplasms, including hepatocellular adenoma, hepatocellular carcinoma and cholangioma.
  • Strong CYP1A immunostaining was detected diffusely in altered cell foci and on the invading margin of hepatocelluar carcinomas.
  • In contrast, CYP1C1 was only detectable and highly expressed in proliferated bile duct epithelial cells.
  • Our CYP1C1 results suggest the potential for tissue specific CYP1C1-mediated PAH metabolism but not a more chronic role in progression to liver hepatocellular carcinoma.

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  • Hazardous Substances Data Bank. Benzo(a)pyrene .
  • Hazardous Substances Data Bank. 7,12-DIMETHYLBENZ(A)ANTHRACENE .
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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
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  • (PMID = 20621368.001).
  • [ISSN] 1879-1514
  • [Journal-full-title] Aquatic toxicology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Aquat. Toxicol.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES012710-05S1; United States / NIEHS NIH HHS / ES / R01 ES012710; United States / NIEHS NIH HHS / ES / R01 ES012710-05S1; United States / NIEHS NIH HHS / ES / R01ES012710
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 3417WMA06D / Benzo(a)pyrene; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; YOW8V9698H / Dimethyl Sulfoxide
  • [Other-IDs] NLM/ NIHMS222714; NLM/ PMC2924930
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4. Barthelmes L, Tait IS: Liver cell adenoma and liver cell adenomatosis. HPB (Oxford); 2005;7(3):186-96

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver cell adenoma and liver cell adenomatosis.
  • During the last three decades liver cell adenoma and liver cell adenomatosis have emerged as new clinical entities in hepato-logical practice due to the widespread use of oral contraceptives and increased imaging of the liver.
  • On review of published series there is evidence that 10% of liver cell adenomas progress to hepatocellular carcinoma, diagnosis is best made by open or laparoscopic excision biopsy, and the preferred treatment modality is resection of the liver cell adenoma to prevent bleeding and malignant transformation.
  • In liver cell adenomatosis, the association with oral contraceptive use is not as high as in solitary liver cell adenomas.
  • The risk of malignant transformation is not increased compared with solitary liver cell adenomas.
  • Treatment consists of close monitoring and imaging, resection of superficially located, large (>4 cm) or growing liver cell adenomas.
  • Liver transplantation is the last resort in case of substantive concern about malignant transformation or for large, painful adenomas in liver cell adenomatosis after treatment attempts by liver resection.

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  • [CommentIn] HPB (Oxford). 2006;8(1):71-2 [18333245.001]
  • (PMID = 18333188.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2023950
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5. Call for HCA medication training. Nurs Stand; 2010 May 12;24(36):10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Call for HCA medication training.
  • : Healthcare assistants (HCAs) working in the independent sector should have comprehensive medication training to prevent vulnerable adults being put at risk, according to a majority of RCN activists.

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  • (PMID = 28010551.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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6. National Toxicology Program: NTP technical report on the toxicology and carcinogenesis studies of beta-myrcene (CAS No. 123-35-3) in F344/N rats and B6C3F1 mice (Gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Dec;(557):1-163
Hazardous Substances Data Bank. MYRCENE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Except for lesion incidence data in groups administered 2 g/kg or less, data from rats that died early were excluded from the analysis and summary tables.
  • Right kidney and liver weights of dosed males and females were generally significantly greater than those of the vehicle controls.
  • The right kidney weights of 1 g/kg females and the liver weights of females administered 0.5 or 1 g/kg were significantly increased.
  • In the standard evaluation of the kidney, the incidence of renal tubule adenoma was significantly increased in 0.5 g/kg male rats, and the combined incidences of renal tubule adenoma or carcinoma were significantly increased in 0.25 and 0.5 g/kg males.
  • In both the extended evaluation and the combined standard and extended evaluations, the incidences of renal tubule adenoma and the combined incidences of renal tubule adenoma or carcinoma were significantly increased in the 0.25 and 0.5 g/kg groups of males.
  • The incidences of liver neoplasms were significantly increased in 0.25 and/or 0.5 g/kg males and 0.25 g/kg females.
  • Liver neoplasms included hepatocellular adenoma and hepatocellular carcinoma in males and females and hepatoblastoma in males.
  • The incidences of hepatocellular hypertrophy were significantly increased in 0.5 g/kg males and females, as was the incidence of mixed cell focus in 0.5 g/kg females.
  • GENETIC TOXICOLOGY: beta-myrcene did not show evidence of genotoxicity in assays conducted by the NTP.
  • No mutagenicity was observed in any of several strains of Salmonella typhimurium or Escherichia coli in two independent Ames assays conducted with and without exogenous metabolic activation.
  • There was equivocal evidence of carcinogenic activity of beta-myrcene in female F344/N rats based on increased incidences of renal tubule adenoma.
  • There was clear evidence of carcinogenic activity of beta-myrcene in male B6C3F1 mice based on increased incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatoblastoma.
  • There was equivocal evidence of carcinogenic activity of beta-myrcene in female B6C3F1 mice based on marginally increased incidences of hepatocellular adenoma and carcinoma.
  • Administration of beta-myrcene induced nonneoplastic lesions in the kidney of male and female rats, nose of male rats, and liver of male and female mice.
  • [MeSH-major] Adenoma / chemically induced. Carcinoma, Hepatocellular / chemically induced. Hepatoblastoma / chemically induced. Kidney Neoplasms / chemically induced. Liver Neoplasms / chemically induced. Monoterpenes / toxicity. Neoplasms, Experimental / chemically induced

  • MedlinePlus Health Information. consumer health - Kidney Cancer.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
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  • (PMID = 21415873.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Monoterpenes; 123-35-3 / beta-myrcene
  • [Investigator] Chan PC; Cesta MF; Sills RC; Bishop JB; Bristol DW; Bucher JR; Chhabra RS; Foster PM; Herbert RA; Hooth MJ; King-Herbert AP; Kissling GE; Malarkey DE; Roycroft JH; Sanders JM; Smith CS; Travlos GS; Walker NJ; Witt KL
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7. Sirli R, Sporea I, Martie A, Popescu A, Dănilă M: Contrast enhanced ultrasound in focal liver lesions--a cost efficiency study. Med Ultrason; 2010 Dec;12(4):280-5
MedlinePlus Health Information. consumer health - Ultrasound.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contrast enhanced ultrasound in focal liver lesions--a cost efficiency study.
  • Contrast enhanced ultrasound (CEUS) has a well established role for the evaluation of focal liver lesions (FLL).
  • A CEUS examination was considered conclusive if, following contrast, the FLL had a typical enhancement pattern(after EFSUMB Guidelines 2008), allowing its classification as hemangioma, FNH, adenoma, hepatocellular carcinoma, metastasis, fatty-free area, focal fatty infiltration.
  • We compared the costs of a CEUS positive diagnosis, to the cost of contrast CT and/or contrast MRI positive diagnosis.
  • RESULTS: In our study were included 316 FLL: 163 (51.6 %) in patients without hepatitis and 153 (48.4 %) in patients with chronic hepatopathies (in 133 cases liver cirrhosis and in 20 cases chronic hepatitis).
  • For the other 66 patients, the diagnosis cost will include the cost of CEUS + the cost of contrast CT: 30,690 RON.
  • If contrast MRI was used for the differential diagnosis, the cost would be 54,780 RON.
  • If contrast CT would be used as the first line diagnosis for the 316 FLL, the cost would be 90,060 RON, by CEUS saving 14,370 RON, or 45.5 RON/lesion (using contrast CT for the differential diagnosis).
  • If contrast MRI would be used as the first line diagnosis, the cost would be 205,400 RON, by CEUS saving 105,620 RON, or 334.2 RON/lesion (using contrast MRI for the differential diagnosis).
  • CONCLUSION: CEUS is a cost-efficient method as a first line diagnosis of FLL as compared to first line contrast-CT or first-line MRI.
  • [MeSH-major] Contrast Media. Liver Diseases / ultrasonography. Liver Neoplasms / ultrasonography. Ultrasonography / economics
  • [MeSH-minor] Cost-Benefit Analysis. Humans. Prospective Studies

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  • (PMID = 21210012.001).
  • [ISSN] 2066-8643
  • [Journal-full-title] Medical ultrasonography
  • [ISO-abbreviation] Med Ultrason
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Contrast Media
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8. National Toxicology Program: Toxicology and carcinogenesis studies of isoeugenol (CAS No. 97-54-1) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Sep;(551):1-178
Hazardous Substances Data Bank. Isoeugenol .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Genetic toxicity tests were conducted in Salmonella typhimurium, Escherichia coli, cultured Chinese hamster ovary cells, and mouse peripheral blood erythrocytes.
  • Liver weights were significantly increased in 300 and 600 mg/kg females.
  • Minimal to mild periportal hepatocellular cytoplasmic alteration occurred in all 300 or 600 mg/kg females.
  • Liver weights of 300 and 600 mg/kg males were significantly greater than those of the vehicle controls.
  • Two male rats in the 300 mg/kg group had rare benign or malignant thymomas, while two other males in this group had rare mammary gland carcinomas.
  • In all groups of exposed males, the incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatocellular adenoma or carcinoma (combined) were significantly greater than those in the vehicle control group; incidences of multiple hepatocellular adenoma were also significantly increased.
  • Incidences of clear cell focus were significantly increased in 75 and 150 mg/kg male mice.
  • GENETIC TOXICOLOGY: Isoeugenol was not mutagenic in two independent assays in bacteria (S. typhimurium and E. coli) conducted with and without exogenous metabolic activation (S9 liver enzymes).
  • Neither did it induce chromosomal aberrations in cultured Chinese hamster ovary cells, with or without S9 activation.
  • There was clear evidence of carcinogenic activity of isoeugenol in male B6C3F1 mice based on increased incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatocellular adenoma or carcinoma (combined).

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  • (PMID = 21372857.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 3T8H1794QW / Eugenol; 97-54-1 / isoeugenol
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9. Macadam J: Government should support trusts in hca conversions. Nurs Stand; 2007 Aug 01;21(47):33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Government should support trusts in hca conversions.
  • : TRUSTS IN HCA CONVERSIONS I am glad to say that after working for the NHS for a number of years as a healthcare assistant (HCA), I was seconded by my mental health trust to start nurse training (news July 25).

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  • (PMID = 28001632.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Snow T: HCA regulation would be costly and ineffective, ministers warned. Nurs Stand; 2009 Jul 01;23(43):5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HCA regulation would be costly and ineffective, ministers warned.
  • : A nurse who led a pilot project that looked at regulating healthcare assistants (HCAs) in the same way as nurses has concluded that the initiative will prove expensive and ineffective.

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  • (PMID = 27996786.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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11. Siviter B: More respect for HCAs. Nurs Stand; 2006 Oct 11;21(5):21-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] More respect for HCAs.
  • The HCA had written: 'Bad day and in a lot of pain.

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  • (PMID = 28090943.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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12. Tustian W: Allowing HCAs to develop is good for patients and nurses. Nurs Stand; 2006 Sep 20;21(2):30-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Allowing HCAs to develop is good for patients and nurses.
  • As a former HCA about to begin my second year of nurse training, I was disappointed to read David Salvage's views on caring responsibilities (reflections August 30).

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  • (PMID = 28086506.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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13. As healthcare assistants take on more responsibility, should they be regulated? Nurs Stand; 2009 Jul 07;23(44):12-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The expanding role of the healthcare assistant (HCA) in primary, acute and independent settings has intensified the debate about whether the workforce should be regulated.

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  • (PMID = 28076098.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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14. Hand T: Standardised training is key for healthcare assistants. Nurs Stand; 2010 Mar 03;24(26):32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Jayne Thomas says healthcare assistant (HCA) training has always been on the job and should remain so (letters February 17).
  • But a recent study and Nursing Standard survey (news February 10) reveal that many HCAs are not receiving training in personal care or basic hygiene.

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  • (PMID = 28080866.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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15. Pickersgill F: Primary assistance. Nurs Stand; 2007 Jun 13;21(40):64

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • As practice nurses are drawn into specialist roles and GPs into more strategic activities, a new workforce of healthcare assistants (HCA) is starting to take on some of the work that practice nurses used to do.

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  • (PMID = 28030126.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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16. Hilton J: Starting out-when i came face to face with the 'too posh to wash' nurses. Nurs Stand; 2006 Nov 08;21(9):24

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 'Leave that dear, that is what the healthcare assistants (HCAs) are for.
  • On the same ward I witnessed a HCA informing a nurse that a colostomy bag needed changing.

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  • (PMID = 27985975.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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17. Mnif N, Ellouze T, Boubela T, Oueslati S, Hamza R: [The place of MRI in the hepatic tumors]. Tunis Med; 2005 Feb;83(2):103-9
Hazardous Substances Data Bank. GADOLINIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The place of MRI in the hepatic tumors].
  • [Transliterated title] Place de l'imagerie par resonance magnetique dans les tumeurs hepatiques.
  • MRI semeiology of hepatic tumors was assessed with a retrospective study of 132 patients explored between May 1998 and December 2001.
  • However, adenoma, hepatocellular carcinoma and metastases have various and less specific features.
  • [MeSH-major] Hemangioma / pathology. Liver Neoplasms / pathology. Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Gadolinium. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 15969233.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Tunisia
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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18. Kendall-Raynor P: 'Emotionally intense' HCA role is overlooked and underpaid. Nurs Stand; 2010 Jun 23;24(42):7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 'Emotionally intense' HCA role is overlooked and underpaid.
  • : Training of healthcare assistants (HCAs) is variable and they are often neglected by managers and nursing colleagues, according to a report by researchers at the University of Oxford.

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  • (PMID = 28019448.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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19. Carter P: RCN vote on hca membership was lost by a tiny margin. Nurs Stand; 2010 Dec 08;25(14):33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] RCN vote on hca membership was lost by a tiny margin.

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  • (PMID = 28019287.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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20. Namasivayam S, Salman K, Mittal PK, Martin D, Small WC: Hypervascular hepatic focal lesions: spectrum of imaging features. Curr Probl Diagn Radiol; 2007 May-Jun;36(3):107-23
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypervascular hepatic focal lesions: spectrum of imaging features.
  • Detection and characterization of liver lesions often present a diagnostic challenge to the radiologists.
  • Liver lesions may be classified as hypovascular and hypervascular based on degree of hepatic arterial blood supply.
  • Common hypervascular liver lesions include hemangioma, focal nodular hyperplasia, hepatocellular adenoma, hepatocellular carcinoma, fibrolamellar carcinoma, and metastases from primary tumors such as islet cell tumor, carcinoid, renal cell carcinoma, melanoma, and thyroid carcinoma.
  • In this review article, we discuss the spectrum of imaging features of hypervascular liver lesions.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adenoma / diagnosis. Hemangioendothelioma / diagnosis. Hemangioma. Humans. Liver / blood supply. Liver Cirrhosis / diagnosis. Melanoma / diagnosis. Melanoma / pathology. Melanoma / secondary. Necrosis. Neoplasm Invasiveness. Portal Vein / pathology

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  • (PMID = 17484954.001).
  • [ISSN] 0363-0188
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Dunne-Howells S: I am a healthcare assistant and an industrious steward. Nurs Stand; 2010 Dec 01;25(13):33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • I was the first healthcare assistant (HCA) in south west England to become a steward and the first to represent his or her branch at regional level.

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  • (PMID = 28026611.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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22. Hailey JR, Walker NJ, Sells DM, Brix AE, Jokinen MP, Nyska A: Classification of proliferative hepatocellular lesions in harlan sprague-dawley rats chronically exposed to dioxin-like compounds. Toxicol Pathol; 2005;33(1):165-74
MedlinePlus Health Information. consumer health - Liver Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Classification of proliferative hepatocellular lesions in harlan sprague-dawley rats chronically exposed to dioxin-like compounds.
  • In the most recent guidelines there appears to be a consensus for classifying these lesions as hepatocellular adenoma, hepatocellular carcinoma, or regenerative hyperplasia.
  • Some nodular hepatocellular lesions from a group of 7 studies of dioxin and dioxin-like compounds conducted by the National Toxicology Program did not readily fit into these categories.
  • Some of these lesions had morphologic features consistent with hyperplasia.
  • In other instances, these lesions had some features resembling adenoma, but contained a prominent component of biliary epithelium and/or oval cells.
  • [MeSH-major] Adenoma, Liver Cell / classification. Carcinoma, Hepatocellular / classification. Dioxins / toxicity. Liver Diseases / classification. Liver Neoplasms, Experimental / classification. Toxicity Tests, Chronic
  • [MeSH-minor] Animals. Drug-Induced Liver Injury. Female. Hyperplasia. Rats. Rats, Sprague-Dawley

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  • (PMID = 15805068.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dioxins
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23. Curvo-Semedo L, Brito JB, Seco MF, Costa JF, Marques CB, Caseiro-Alves F: The hypointense liver lesion on T2-weighted MR images and what it means. Radiographics; 2010 Jan;30(1):e38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The hypointense liver lesion on T2-weighted MR images and what it means.
  • The vast majority of focal liver lesions are hyperintense on T2-weighted magnetic resonance (MR) images.
  • Rarely, however, hepatic nodules may appear totally or partially hypointense on those images.
  • Although rare, low signal intensity relative to surrounding liver on T2-weighted images may be seen in a wide spectrum of lesions.
  • Examples include cases of focal nodular hyperplasia, hepatocellular adenoma, hepatocellular carcinoma, metastases, leiomyoma, siderotic or dysplastic nodules, nodules in Wilson disease, granuloma, and hydatid cyst.
  • On fat-suppressed T2-weighted images, nodules with a lipomatous component, such as lipoma, angiomyolipoma, hepatocellular adenoma, and hepatocellular carcinoma may also appear partially or totally hypointense.
  • The conjunction of other MR imaging findings and their integration in the clinical setting may allow a correct diagnosis in a considerable proportion of cases.
  • The aims of this work are to discuss the causes and mechanisms of hypointensity of liver lesions on T2-weighted images and proposing an algorithm for classification that may be useful as a quick reminder for the interested reader.
  • [MeSH-major] Algorithms. Image Enhancement / methods. Liver / pathology. Liver Diseases / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 19901085.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Zhuang TF, Qiu ZQ, Wei M, Huang SZ: [Mutation analysis of glycogen debrancher enzyme gene in five Chinese patients with glycogen storage disease type III]. Zhonghua Er Ke Za Zhi; 2005 Feb;43(2):85-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mutation analysis of glycogen debrancher enzyme gene in five Chinese patients with glycogen storage disease type III].
  • OBJECTIVE: Type III glycogen storage disease (GSD-III, McKusick 232400), is a rare autosomal recessive disorder, also known as Cori's or Forbe's disease.
  • The hepatocellular adenoma, hepatocellular carcinoma, diabetes mellitus and liver fibrosis remain rare events.
  • The diagnosis of debrancher deficiency was established by laboratory tests, electromyography (EMG), and muscle and liver biopsy.
  • Analysis of 33 exons and part exon-intron boundaries of the AGL gene in patients and their parents were carried out by PCR and direct DNA sequencing.
  • Administration of raw-corn-starch could maintain normoglycemia and improve the disease condition.
  • Mutation analysis for patient 1 was normal.
  • Patient 2 had a compound heterozygote: a C-to-T transition at nucleotide 1294 (come from father, 1294C > T, L 298 L) in exon 8 and a G-to-T transition at nucleotide 4747 (from mother, 4747G > T, E1450X) in exon 34.
  • Patient 3 had a compound heterozygote: a C-to-T transition at nucleotide 1294 (from father, 1294C > T, L 298 L) in exon 8 and a G-to-A transition at nucleotide -10 (from mother, -10G > A) in exon 3.
  • Patient 4 was a homozygote: an insertion of a nucleotide CT into position +65 in exon 35 (4664 ins CT).
  • Administration of raw-corn-starch can effectively improve the disease outcome.
  • We identified 8 new mutations on AGL gene through nucleotide sequence analysis.
  • [MeSH-major] Glycogen Debranching Enzyme System / genetics. Glycogen Storage Disease Type III / genetics. Mutation

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  • (PMID = 15833157.001).
  • [ISSN] 0578-1310
  • [Journal-full-title] Zhonghua er ke za zhi = Chinese journal of pediatrics
  • [ISO-abbreviation] Zhonghua Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glycogen Debranching Enzyme System; EC 3.2.1.33 / amylo-1,6-glucosidase
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25. Parish C: HCA training cuts could impede shift of care into community. Nurs Stand; 2006 Oct 11;21(5):9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HCA training cuts could impede shift of care into community.
  • Funding for healthcare assistants' (HCAs) training has been slashed as strategic health authorities (SHAs) struggle with their budgets.

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  • (PMID = 28090969.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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26. Blakemore S: Government adviser calls for minimum nurse-to-HCA ratio. Nurs Stand; 2009 May 06;23(35):5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Government adviser calls for minimum nurse-to-HCA ratio.

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  • (PMID = 27996594.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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27. College council to vote on wider HCA membership. Nurs Stand; 2007 Mar 14;21(27):11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] College council to vote on wider HCA membership.
  • : The RCN is set to open its doors to all healthcare assistants (HCAs) in a move that is likely to push its membership over 400,000 for the first time.

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  • (PMID = 27958943.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. Bisceglia M, Gatta A, Tomezzoli A, Donataccio M: Multiple spontaneous liver cell adenomas of different types (liver adenomatosis). Adv Anat Pathol; 2009 May;16(3):172-9
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple spontaneous liver cell adenomas of different types (liver adenomatosis).
  • Hepatocellular adenoma (HCA) was classically considered by definition a neoplasm with no ductal or ductular differentiation, but today the spectrum of HCA does include variant 3, which may have CK7+ ductules.
  • Owing to genotypic-phenotypic correlation, T-FNH (synonymous with progressive FNH of others) is not considered yet as part of the spectrum of FNH, instead it is diagnosed as a variant of HCA, which now includes 4 variants.
  • Variant-3, which may contain CK7+ ductules, and is also termed HCA with ductal/ductular differentiation, corresponds to T-FNH.
  • Notwithstanding the nosologic advancement, and outside the "archetypal" types, the differential morphologic diagnosis of spontaneous HCA versus FNH may remain problematic as ductular proliferation in some cases of FNH may be scanty and hard to find.
  • In some histologic overlapping cases of FNH and HCA the morphologic diagnosis may be very difficult or even impossible (especially in small lesions) and molecular biology may be of critical assistance.
  • A prototypical case of surgically resected multiple spontaneous liver cell adenomas of various types, including HCA of T-FNH type and steatotic type, previously interpreted in different ways, affecting a young girl, is presented herein.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Adolescent. Female. Focal Nodular Hyperplasia / pathology. Humans. Liver / pathology

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  • (PMID = 19395881.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Flemming P, Lehmann U, Steinemann D, Kreipe H, Wilkens L: [Hepatocellular adenoma. Malignancy potential and differentiation from hepatocellular carcinoma]. Pathologe; 2006 Jul;27(4):238-43
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hepatocellular adenoma. Malignancy potential and differentiation from hepatocellular carcinoma].
  • [Transliterated title] Leberzelladenom. Entartungspotenzial und Abgrenzung vom hepatozellulären Karzinom.
  • In contrast to hepatocellular carcinoma (HCC), very few molecular pathological studies have been carried out on hepatocellular adenoma (HCA).
  • Particularly from the surgical point of view, based on views passed on verbally and in the literature of the 1970s and 1980s, a possible degeneration of the HCA provides grounds for operating.
  • Published cases of transitions from HCA into HCC were evaluated on the basis of today's morphological standards.
  • A comparison was made between the patterns of new molecular pathological studies of HCA, above all the work of our own groups, and those of HCC.
  • The results speak against the suggestion that a typical solitary HCA in pre-menopausal women is a precursor lesion of HCC.
  • After a critical review of the literature, only one casuistic case of a transition of HCA to HCC under a hormone therapy, which is no longer practiced today, remained.
  • A limitation of particular HCA in genetic and metabolic diseases, children, adult males, adenomatosis, and HCA-like tumors with known risk factors of HCC would seem pragmatically meaningful.
  • With classic HCA, however, the oncological indication for surgery does not apply.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Middle Aged

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  • (PMID = 16736176.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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30. Hibbert A: The factors that affect HCA routes into nurse training. Nurs Times; 2006 Jan 3-9;102(1):32-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The factors that affect HCA routes into nurse training.
  • METHOD: Semistructured telephone interviews were used to gain the views of strategic health authorities and workforce development directorates on HCA progression.
  • These were compared with the Department of Health's figures on HCA progression.
  • RESULTS: The main findings indicate that a new definition for the role of HCA is essential in order to monitor HCA progression.
  • In addition, establishing more robust and transparent systems designed to support learning opportunities for HCAs is required, including accreditation of prior experiential learning systems.
  • CONCLUSION: It appears there is inconsistency in practice across England and there are relatively few opportunities for HCA advancement.
  • Recommendations for ways to support HCAs prior to devolving budgets and responsibility are offered.

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  • (PMID = 16425754.001).
  • [ISSN] 0954-7762
  • [Journal-full-title] Nursing times
  • [ISO-abbreviation] Nurs Times
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Wang D, Lagerstrom R, Sun C, Bishof L, Valotton P, Götte M: HCA-vision: Automated neurite outgrowth analysis. J Biomol Screen; 2010 Oct;15(9):1165-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HCA-vision: Automated neurite outgrowth analysis.
  • Automating the analysis of neurons in culture represents a key aspect of the search for neuroactive compounds.
  • A number of commercial neurite analysis software packages tend to measure some basic features such as total neurite length and number of branching points.
  • The authors have developed a suite of image analysis tools that will allow researchers to produce quality analyses at primary screening rates.
  • In mixed cell populations, neurons can be filtered and separated from other brain cell types so that neurite analysis can be performed only on neurons.
  • It supports batch processing with a built-in database to store the batch-processing results, a batch result viewer, and an ad hoc query builder for users to retrieve features of interest.
  • The suite of tools has been deployed into a software package called HCA-Vision.
  • The free version of the software package is available at http://www.hca-vision.com.

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  • (PMID = 20855562.001).
  • [ISSN] 1552-454X
  • [Journal-full-title] Journal of biomolecular screening
  • [ISO-abbreviation] J Biomol Screen
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor
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32. Vallotton P, Lagerstrom R, Sun C, Buckley M, Wang D, De Silva M, Tan SS, Gunnersen JM: Automated analysis of neurite branching in cultured cortical neurons using HCA-Vision. Cytometry A; 2007 Oct;71(10):889-95
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Automated analysis of neurite branching in cultured cortical neurons using HCA-Vision.
  • We have developed fast, sensitive, and reliable algorithms for the purpose of detecting and analyzing neurites in cell cultures, and we have integrated them in software called HCA-Vision, suitable for the research environment.
  • We validate the software on images of cortical neurons by comparing results obtained using HCA-Vision with those obtained using an established semi-automated tracing solution (NeuronJ).
  • HCA-Vision delivered considerable speed benefits and reliable traces.
  • [MeSH-minor] Animals. Cells, Cultured. Image Processing, Computer-Assisted. Mice. Mice, Knockout

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  • (PMID = 17868085.001).
  • [ISSN] 1552-4922
  • [Journal-full-title] Cytometry. Part A : the journal of the International Society for Analytical Cytology
  • [ISO-abbreviation] Cytometry A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Bioulac-Sage P, Laumonier H, Laurent C, Zucman-Rossi J, Balabaud C: Hepatocellular adenoma: what is new in 2008. Hepatol Int; 2008 Sep;2(3):316-21
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatocellular adenoma: what is new in 2008.
  • Patients (85%) with hepatocellular adenoma (HCA) are women taking oral contraceptives.
  • They can be divided into four subgroups according to their genotype/phenotype features. (1) Hepatocyte nuclear factor 1alpha (HNF1alpha) biallelic somatic mutations are observed in 35% of the HCA cases.
  • HNF1alpha-mutated HCA are most of the time, highly steatotic, with a lack of expression of liver fatty acid binding protein (LFABP) in immunohistochemistry analyses.
  • An HNF1alpha germline mutation is observed in less than 5% of HCA cases and can be associated with MODY 3 diabetes. (2) An activating beta-catenin mutation was found in 10% of HCA.
  • These beta-catenin activated HCAs are observed in men and women, and specific risk factors, such as male hormone administration or glycogenosis, are associated with their development.
  • Immunohistochemistry studies show that these HCAs overexpress beta-catenin (nuclear and cytoplasmic) and glutamine synthetase.
  • This group of tumours has a higher risk of malignant transformation into hepatocellular carcinoma. (3) Inflammatory HCAs are observed in 40% of the cases, and they are most frequent in women but are also found in men.
  • An additional 10% of inflammatory HCAs express beta-catenin, and are also at risk of malignant transformation. (4) Currently, less than 10% of HCAs are unclassified.
  • It is hoped that in the near future it will be possible with clinical, biological and imaging data to predict in which of the 2 major groups (HNF1alpha-mutated HCA and inflammatory HCA) the patient belongs and to propose better guidelines in terms of surveillance and treatment.

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  • (PMID = 19669260.001).
  • [ISSN] 1936-0533
  • [Journal-full-title] Hepatology international
  • [ISO-abbreviation] Hepatol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2716879
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34. Pineau C, Freydier A, Ranocha P, Jauneau A, Turner S, Lemonnier G, Renou JP, Tarkowski P, Sandberg G, Jouanin L, Sundberg B, Boudet AM, Goffner D, Pichon M: hca: an Arabidopsis mutant exhibiting unusual cambial activity and altered vascular patterning. Plant J; 2005 Oct;44(2):271-89
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] hca: an Arabidopsis mutant exhibiting unusual cambial activity and altered vascular patterning.
  • This phenotype is the consequence of premature and numerous cambial cell divisions in both the fascicular and interfascicular regions that result in the loss of the alternate vascular bundle/fiber organization typically observed in Arabidopsis stems.
  • The mutant was therefore designated high cambial activity (hca).
  • The hca mutation also resulted in pleiotropic effects including stunting and a delay in developmental events such as flowering and senescence.
  • The physiological characterization of hca seedlings in vitro revealed an altered auxin and cytokinin response and, most strikingly, an enhanced sensitivity to cytokinin.
  • These results were substantiated by comparative microarray analysis between hca and wild-type plants.
  • The genetic analysis of hca indicated that the mutant phenotype was not tagged by the T-DNA and that the hca mutation segregated as a single recessive locus, mapping to the long arm of chromosome 4.
  • We propose that hca is involved in mechanisms controlling the arrangement of vascular bundles throughout the plant by regulating the auxin-cytokinin sensitivity of vascular cambial cells.
  • Thus, the hca mutant is a useful model for examining the genetic and hormonal control of cambial growth and differentiation.

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  • (PMID = 16212606.001).
  • [ISSN] 0960-7412
  • [Journal-full-title] The Plant journal : for cell and molecular biology
  • [ISO-abbreviation] Plant J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ATHB-8 protein, Arabidopsis; 0 / Arabidopsis Proteins; 0 / Cytokinins; 0 / DNA, Bacterial; 0 / Homeodomain Proteins; 0 / Indoleacetic Acids; 0 / T-DNA; 0 / Transcription Factors
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35. Okamura T, Ishibashi N, Kumar TS, Zurakowski D, Iwata Y, Lidov HG, Jonas RA: Hypothermic circulatory arrest increases permeability of the blood brain barrier in watershed areas. Ann Thorac Surg; 2010 Dec;90(6):2001-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypothermic circulatory arrest increases permeability of the blood brain barrier in watershed areas.
  • BACKGROUND: The integrity of the blood brain barrier (BBB) after cardiopulmonary bypass (CPB) with hypothermic circulatory arrest (HCA) is controversial in children.
  • We tested the hypothesis that the BBB is disrupted by HCA.
  • Five groups (25 piglets, 5 per group) underwent acute studies: anesthesia alone (control); CPB at 37°C with full-flow (FF); CPB at 25°C with very low flow (LF); HCA at 15°C, and HCA at 25°C.
  • Two groups (16 piglets, 8 per group) underwent survival studies: CPB at 25°C with LF and HCA.
  • RESULTS: The BBB disruption was clearly observed around watershed areas for 25°C HCA compared with other conditions.
  • Microscopic data showed that leakage of EBD in 25°C HCA was more severe than control in all brain areas (p < 0.05), and EBD and albumin were colocalizing.
  • Histologic damage scores were significantly higher in watershed areas with 25°C HCA.
  • CONCLUSIONS: The BBB was impaired around watershed areas by 25°C HCA for 1 hour according to both macroscopic and microscopic data.

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  • [Copyright] Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
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  • [CommentIn] Ann Thorac Surg. 2010 Dec;90(6):2008 [21095353.001]
  • (PMID = 21095352.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL060922; United States / NHLBI NIH HHS / HL / R01 HL104173; United States / NHLBI NIH HHS / HL / R01 HL060922-10; United States / NHLBI NIH HHS / HL / HL060922-10; United States / NHLBI NIH HHS / HL / R01-HL060922
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Coloring Agents; 45PG892GO1 / Evans Blue
  • [Other-IDs] NLM/ NIHMS270753; NLM/ PMC3043641
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36. Lee KH, Lee BM: Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia. J Toxicol Environ Health A; 2007 Mar 1;70(5):388-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia.
  • (-)-Hydroxycitric acid (HCA) is widely used as an ingredient for nutritional supplements aimed at reducing food intake, appetite, and body weight.
  • In this study, the genotoxicity of HCA was evaluated using three tests: a bacterial reverse mutation assay (Ames test), an in vitro chromosomal aberration (CA) test, and an in vivo micronucleus (MN) test.
  • HCA was negative by the Ames test in the presence or absence of a microsomal metabolizing system.
  • HCA did not induce mutagenic activity in the Ames test, and no significant mutagenic potency was indicated by CA tests.
  • However, HCA significantly and dose-dependently increased the number of MNPCEs (micronucleated polychromatic erythrocytes/1000 polychromatic erythrocytes) and PCE/(PCE + NCE) ratios according to the MN test.
  • These results suggest that HCA preferentially induce micronuclei.
  • [MeSH-minor] Animals. Cell Line. Chromosome Aberrations / chemically induced. Cricetinae. Cricetulus. Garcinia cambogia. Mice. Mutagenicity Tests

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  • [CommentIn] J Toxicol Environ Health A. 2008;71(5):348-9; author reply 350-1 [18214809.001]
  • (PMID = 17454564.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Citrates; 8W94T9026R / hydroxycitric acid
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37. Ohno M, Omoto T, Fukuzumi M, Oi M, Ishikawa N, Tedoriya T: Hypothermic circulatory arrest: renal protection by atrial natriuretic peptide. Asian Cardiovasc Thorac Ann; 2009 Aug;17(4):401-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypothermic circulatory arrest: renal protection by atrial natriuretic peptide.
  • Moderate hypothermic circulatory arrest with selective cerebral perfusion has been developed for cerebral protection during thoracic aortic surgery.
  • However, visceral organs, particularly the kidneys, suffer greater tissue damage under moderate hypothermic circulatory arrest, and acute renal failure after hypothermic circulatory arrest is an independent risk factor for early and late mortality.
  • This study investigated whether atrial natriuretic peptide could prevent the reduction in renal perfusion and protect renal function after moderate hypothermic circulatory arrest.
  • Moderate hypothermic circulatory arrest was induced for 60 min.
  • However, renal medullary blood flow increased significantly in the peptide-treated group after hypothermic circulatory arrest.
  • Renal medullary ischemia after hypothermic circulatory arrest was ameliorated by atrial natriuretic peptide which increased medullary blood flow and reduced sodium reabsorption in the medulla.
  • [MeSH-major] Atrial Natriuretic Factor / administration & dosage. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Ischemia / prevention & control. Kidney / blood supply. Renal Circulation / drug effects
  • [MeSH-minor] Animals. Blood Flow Velocity / drug effects. Blood Pressure / drug effects. Cardiopulmonary Bypass. Creatinine / blood. Disease Models, Animal. Female. Inflammation Mediators / metabolism. Laser-Doppler Flowmetry. Natriuresis / drug effects. Peroxidase / metabolism. Recombinant Proteins / administration & dosage. Swine. Time Factors. Urination / drug effects

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  • (PMID = 19713338.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Inflammation Mediators; 0 / Recombinant Proteins; 85637-73-6 / Atrial Natriuretic Factor; AYI8EX34EU / Creatinine; EC 1.11.1.7 / Peroxidase
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38. Shuhaiber JH: Evaluating the quality of trials of hypothermic circulatory arrest aortic surgery. Asian Cardiovasc Thorac Ann; 2007 Oct;15(5):449-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluating the quality of trials of hypothermic circulatory arrest aortic surgery.
  • The quality of level 1 evidence in reports on deep hypothermic circulatory arrest was assessed, and the confounding factors in surgical management and study design that can prevent meta-analysis formulation were determined.
  • A systematic search of the literature was conducted using categorized nomenclature for randomized controlled trials in adult patients undergoing deep hypothermic circulatory arrest in the last 40 years.
  • Twelve randomized controlled trials (2.3%) were found among 504 publications on deep hypothermic circulatory arrest listed on Medline from 1960; only 4 of them related to adults.
  • One adequately powered study demonstrated reduced blood loss in deep hypothermic circulatory arrest using aprotinin.
  • Existing studies of deep hypothermic circulatory arrest are insufficient and inconsistent in the outcome measured, which explains the lack of a meta-analysis.
  • [MeSH-major] Aortic Diseases / surgery. Cerebrovascular Disorders / etiology. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Meta-Analysis as Topic. Randomized Controlled Trials as Topic / standards. Vascular Surgical Procedures

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  • (PMID = 17911080.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 17
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39. Gammie JS, Landree B, Griffith BP: Integrated cerebral protection: combined antegrade and retrograde cerebral perfusion during deep hypothermic circulatory arrest. Innovations (Phila); 2010 Sep;5(5):355-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Integrated cerebral protection: combined antegrade and retrograde cerebral perfusion during deep hypothermic circulatory arrest.
  • Hypothermic circulatory arrest (HCA) is an established method of central nervous system protection for limited periods of absent cerebral blood flow.
  • Adjuncts to increase the safe duration of circulatory arrest include either retrograde cerebral perfusion (RCP) or antegrade cerebral perfusion (ACP), with most complex aortic operations now performed using HCA with ACP.
  • METHODS: The integrated brain protection strategy included sequential overlapping periods of RCP, ACP, and RCP during HCA.
  • RESULTS: Between 2008 and 2009, six consecutive patients underwent ascending aortic graft replacement for acute type A dissection using HCA and integrated brain protection.
  • The mean minimum systemic temperature was 22.9 ± 1.8°C, the mean total HCA time was 34 ± 5 minutes, and the mean duration of ACP and RCP was 22 ± 6 and 7 ± 5 minutes, respectively.
  • CONCLUSIONS: Integrated brain protection using both RCP and ACP during HCA is a promising approach for the safe performance of complex aortic surgery and is worthy of evaluation in larger clinical series.

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  • (PMID = 22437521.001).
  • [ISSN] 1559-0879
  • [Journal-full-title] Innovations (Philadelphia, Pa.)
  • [ISO-abbreviation] Innovations (Phila)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Schmoker JD, Terrien C 3rd, McPartland KJ, Boyum J, Wellman GC, Trombley L, Kinne J: Cerebrovascular response to continuous cold perfusion and hypothermic circulatory arrest. J Thorac Cardiovasc Surg; 2009 Feb;137(2):459-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebrovascular response to continuous cold perfusion and hypothermic circulatory arrest.
  • OBJECTIVE: Clinical and laboratory studies have documented changes in cerebrovascular resistance after hypothermic circulatory arrest, both with and without adjunctive cerebral perfusion modalities.
  • METHODS: Four mature swine underwent hypothermic circulatory arrest for 60 minutes, and 7 mature swine underwent cold cerebral perfusion for 60 minutes to simulate antegrade selective perfusion.
  • RESULTS: Cold perfusion caused pial arteriole and venule constriction, whereas hypothermic circulatory arrest alone caused pial arteriole and venule dilatation.
  • Hypothermic circulatory arrest caused a loss of nitric oxide-mediated endothelium-dependent vasodilatation.
  • Endothelial cells from the cold group had a vasoconstrictive secretory phenotype, whereas endothelial cells from the hypothermic circulatory arrest group had a vasodilatory phenotype.
  • Hypothermic circulatory arrest alone is associated with endothelium-dependent vasoparesis.
  • [MeSH-major] Cerebrovascular Circulation. Heart Arrest, Induced
  • [MeSH-minor] Animals. Cerebral Veins / physiology. Endothelial Cells / physiology. Endothelins / secretion. Hemodynamics. Hypothermia, Induced. Microcirculation. Prostaglandins I / secretion. Swine. Vasoconstriction

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  • (PMID = 19185170.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Endothelins; 0 / Prostaglandins I
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41. van den Esschert JW, van Gulik TM, Phoa SS: Imaging modalities for focal nodular hyperplasia and hepatocellular adenoma. Dig Surg; 2010;27(1):46-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging modalities for focal nodular hyperplasia and hepatocellular adenoma.
  • BACKGROUND/AIMS: There are several imaging modalities available for the detection of focal liver lesions.
  • Differentiation between focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) is important because of the consequences for management.
  • METHODS: We reviewed the literature for typical features of FNH and HCA on radiologic and nuclear imaging with emphasis on differentiation of both lesions.
  • RESULTS: Seven articles describe the performance of an imaging modality for the differentiation between FNH and HCA.
  • Limitations of these studies are the small sample size and/or the lack of comparison with the 'gold standard', i.e. histological diagnosis.
  • No studies are available that compare the accuracy of several imaging modalities in the differentiation of FNH and HCA.
  • On contrast-enhanced US, the arterial filling direction of FNH is centrifugal and centripetal in case of HCA.
  • The parenchymal enhancement of FNH is sustained in the portal venous and delayed phases, but shows rapid washout in case of HCA.
  • Multiphase CT scan can differentiate FNH from HCA when there is a central scar.
  • On MRI with hepatocyte-specific contrast agents, HCA does not show contrast uptake in the hepatobiliary phase in contrast to FNH.
  • CONCLUSION: We conclude that there is limited evidence of the diagnostic performance of currently used imaging modalities for the differentiation of FNH and HCA.
  • We therefore propose a prospective study (DiFA trial) to determine the accuracy of several radiologic and nuclear imaging studies in differentiating FNH and HCA.
  • [MeSH-major] Adenoma, Liver Cell / diagnosis. Focal Nodular Hyperplasia / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Tomography, Spiral Computed

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20357451.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 68
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42. Chen YC, Hsu RB: Aortic surgery requiring hypothermic circulatory arrest in octogenarians. J Formos Med Assoc; 2008 May;107(5):412-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aortic surgery requiring hypothermic circulatory arrest in octogenarians.
  • BACKGROUND: Recent improvements in the outcomes of cardiovascular operation in octogenarians have resulted in an increase in the number of referrals of elderly patients for aortic surgery requiring hypothermic circulatory arrest.
  • RESULTS: Between 2000 and 2007, 12 octogenarians with aortic aneurysms underwent surgery requiring hypothermic circulatory arrest.
  • Diagnoses of aortic disease included acute type A aortic dissection in seven patients and degenerative thoracic aneurysm in five.
  • The median duration of hypothermic circulatory arrest was 50 minutes (range, 15-84 minutes).
  • Method of brain protection during hypothermia was selective antegrade cerebral perfusion in five patients, retrograde cerebral perfusion in two, and arrest alone in five.
  • CONCLUSION: Although postoperative complications were common, the clinical outcome of aortic surgery requiring hypothermic circulatory arrest was acceptable.

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  • (PMID = 18492626.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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43. Kamiya H, Hagl C, Kropivnitskaya I, Weidemann J, Kallenbach K, Khaladj N, Haverich A, Karck M: Quick proximal arch replacement with moderate hypothermic circulatory arrest. Ann Thorac Surg; 2007 Mar;83(3):1055-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quick proximal arch replacement with moderate hypothermic circulatory arrest.
  • BACKGROUND: The aim of this study is to evaluate the safety of proximal arch repair using only moderate hypothermic circulatory arrest (HCA) at a temperature of 25 degrees C to 28 degrees C without any adjunctive cerebral protection in comparison with those with moderate HCA and selective cerebral perfusion.
  • METHODS: Thirty patients who underwent proximal arch repair using moderate HCA without selective cerebral perfusion (SCP) were retrospectively examined and defined as the SCP (-) group.
  • As a control group, 31 patients who underwent moderate HCA and SCP within 10 minutes were included in this study and defined as the SCP (+) group.
  • RESULTS: Mean circulatory arrest time was 9.4 +/- 0.8 minutes and 7.5 +/- 1.8 minutes (p = 0.0001) and mean nasopharyngeal temperature at the induction of the circulatory arrest was 26.0 +/- 1.2 degrees C and 26.8 +/- 1.3 degrees C (p = 0.014) in the SCP (+) group and SCP (-) group, respectively.
  • CONCLUSIONS: It was possible to perform proximal arch replacement in selected patients using moderate HCA without any adjunctive cerebral protection with excellent results, and no advantage of the use of SCP was found in patients who required short HCA for proximal arch replacement.
  • [MeSH-major] Aorta, Thoracic / surgery. Aortic Diseases / surgery. Blood Vessel Prosthesis Implantation. Heart Arrest, Induced. Hypothermia, Induced / methods. Vascular Surgical Procedures

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  • (PMID = 17307459.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
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44. Kim S, Lee KG: Effects of cooking variables on formation of heterocyclic amines (HCA) in roasted pork and mackerel. J Toxicol Environ Health A; 2010;73(21-22):1599-609
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of cooking variables on formation of heterocyclic amines (HCA) in roasted pork and mackerel.
  • The aim of this study was to evaluate the effects of cooking temperature, time, and water content on the formation of heterocyclic amines (HCA) in roasted pork and mackerel using a kinetic model.
  • The concentration of PhIP ranged from 6 to 54 ng/g in roasted pork and was the HCA most sensitive to cooking temperature and time.
  • The kinetics of HCA generation followed first-order reaction (A = A(0) × e(-kt)).
  • The activation entropies (ΔS) were less than zero for all HCA, ranging from -159 to -309 kJ/mol-K.
  • The data of the kinetic parameters may be used to predict the formation and temperature sensitivity of HCA in roasted pork and mackerel.
  • [MeSH-major] Amines / analysis. Cooking / methods. Food Contamination / analysis. Heterocyclic Compounds / analysis. Meat / analysis. Perciformes

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  • (PMID = 20954084.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Amines; 0 / Heterocyclic Compounds
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45. Tanaka T, Ohkubo S, Tatsuno I, Prives C: hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell; 2007 Aug 24;130(4):638-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes.
  • The p53 tumor suppressor protein regulates many genes that can determine different cellular outcomes such as growth arrest or cell death.
  • We report here that the human cellular apoptosis susceptibility protein (hCAS/CSE1L) associates with a subset of p53 target promoters, including PIG3, in a p53-autonomous manner.
  • Downregulation of hCAS/CSE1L decreases transcription from those p53 target promoters to which it preferentially binds and reduces apoptosis.
  • In addition, hCAS/CSE1L silencing leads to increased methylation of histone H3 lysine 27 within the PIG3 gene. hCAS/CSE1L was previously shown to function as a nucleo-cytoplasmic transport factor, as does its closely related yeast homologue Cse1, which can also associate with chromatin and serve as a barrier protein that prevents spreading of heterochromatin.
  • [MeSH-minor] Amino Acid Sequence. Breast Neoplasms / pathology. Cell Culture Techniques. Cell Line. Cell Line, Tumor. Chromatin Immunoprecipitation. Conserved Sequence. DNA Methylation. Female. Gene Expression Regulation. Gene Silencing. HCT116 Cells. Histones / metabolism. Humans. Kidney / cytology. Models, Biological. Molecular Sequence Data. Plasmids. Promoter Regions, Genetic. RNA Interference. Sequence Homology, Amino Acid

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  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
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  • [CommentIn] Cell. 2007 Aug 24;130(4):597-600 [17719538.001]
  • (PMID = 17719542.001).
  • [ISSN] 0092-8674
  • [Journal-full-title] Cell
  • [ISO-abbreviation] Cell
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA77742
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cellular Apoptosis Susceptibility Protein; 0 / Chromatin; 0 / Histones; 0 / Tumor Suppressor Protein p53
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46. Robertson FM: High-Content Analysis--CHI's Seventh Annual Conference--Developments in HCA and Pathway Analysis. IDrugs; 2010 Mar;13(3):149-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-Content Analysis--CHI's Seventh Annual Conference--Developments in HCA and Pathway Analysis.
  • CHI's Seventh Annual Conference on High-Content Analysis (HCA), held in San Francisco, incorporated topics covering new developments in the field of HCA, including hardware and software updates, new biological models for HCA and pathway analysis.
  • This conference report highlights selected presentations on the use of HCA for the characterization of stem cells, cell-colony analysis, the validation of disease models and the identification of antiparasitic compounds.
  • [MeSH-major] Drug Discovery / trends. Gene Regulatory Networks. High-Throughput Screening Assays / trends. Signal Transduction. Systems Biology / trends
  • [MeSH-minor] Animals. Animals, Genetically Modified. Antiparasitic Agents / pharmacology. Caenorhabditis elegans / enzymology. Caenorhabditis elegans / genetics. Embryonic Stem Cells / metabolism. Fibroblast Growth Factors / genetics. Fibroblast Growth Factors / metabolism. Humans. Models, Biological. Neoplastic Stem Cells / metabolism. Ubiquitin-Protein Ligases / metabolism. Zebrafish / genetics. Zebrafish / metabolism. alpha 1-Antitrypsin Deficiency / enzymology. alpha 1-Antitrypsin Deficiency / genetics

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  • (PMID = 20191427.001).
  • [ISSN] 2040-3410
  • [Journal-full-title] IDrugs : the investigational drugs journal
  • [ISO-abbreviation] IDrugs
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antiparasitic Agents; 62031-54-3 / Fibroblast Growth Factors; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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47. Estrera AL, Miller CC, Lee TY, Shah P, Irani AD, Ganim N, Abdullah S, Safi HJ: Integrated cerebral perfusion for hypothermic circulatory arrest during transverse aortic arch repairs. Eur J Cardiothorac Surg; 2010 Sep;38(3):293-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Integrated cerebral perfusion for hypothermic circulatory arrest during transverse aortic arch repairs.
  • OBJECTIVES: Antegrade cerebral perfusion (ACP) during hypothermic circulatory arrest (HCA) for ascending/transverse arch repair is used for cerebral protection.
  • This study evaluates ACP in combination with retrograde cerebral perfusion (RCP) during extended HCA and compares it to RCP-only.
  • METHODS: Between January 2005 and April 2007, we performed 64 consecutive arch repairs requiring extended HCA (>40 min).
  • Mean HCA time was 51 + or - 13 min.
  • [MeSH-minor] Adult. Aged. Blood Vessel Prosthesis Implantation / methods. Brain Ischemia / prevention & control. Female. Heart Arrest, Induced / methods. Heart Valve Prosthesis Implantation / methods. Humans. Hypothermia, Induced / methods. Intraoperative Care / methods. Male. Middle Aged. Perfusion / methods. Retrospective Studies

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  • [Copyright] Copyright 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20304662.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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48. Tobias JD, Russo P, Russo J: Changes in near infrared spectroscopy during deep hypothermic circulatory arrest. Ann Card Anaesth; 2009 Jan-Jun;12(1):17-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Changes in near infrared spectroscopy during deep hypothermic circulatory arrest.
  • Data regarding the performance of near infrared spectroscopy monitoring during deep hypothermic circulatory arrest are limited.
  • The current study presents data regarding use of a commercially available near infrared spectroscopy monitor during deep hypothermic circulatory arrest in paediatric patients undergoing surgery for congenital heart disease.
  • The cohort included 8 patients, 2 weeks to 6 months of age, who required deep hypothermic circulatory arrest for repair of congenital heart disease.
  • The duration of deep hypothermic circulatory arrest varied from 36 to 61 min (43.4 +/- 8 min).
  • After the onset of deep hypothermic circulatory arrest, there was an incremental decrease in cerebral oxygenation to a low value of 53 +/- 11%.
  • The greatest decrease occurred during the initial 5 min of deep hypothermic circulatory arrest (9 +/- 3%).
  • Over the entire period of deep hypothermic circulatory arrest, there was an average decrease in the cerebral oxygenation value of 0.9% per min (range of 0.5 to 1.6% decline per minute).
  • During cardiopulmonary bypass, cooling and deep hypothermic circulatory arrest, near infrared spectroscopy monitoring followed the clinically expected parameters.
  • [MeSH-major] Brain Ischemia / diagnosis. Cardiopulmonary Bypass / instrumentation. Circulatory Arrest, Deep Hypothermia Induced / instrumentation. Heart Defects, Congenital / surgery. Spectroscopy, Near-Infrared / statistics & numerical data
  • [MeSH-minor] Blood Gas Analysis. Blood Gas Monitoring, Transcutaneous / instrumentation. Blood Gas Monitoring, Transcutaneous / methods. Blood Gas Monitoring, Transcutaneous / statistics & numerical data. Electroencephalography / methods. Female. Humans. Infant. Infant, Newborn. Male. Outcome Assessment (Health Care). Retrospective Studies. Time Factors

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  • (PMID = 19136750.001).
  • [ISSN] 0974-5181
  • [Journal-full-title] Annals of cardiac anaesthesia
  • [ISO-abbreviation] Ann Card Anaesth
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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49. Tseng EE, Brock MV, Lange MS, Troncoso JC, Blue ME, Lowenstein CJ, Johnston MV, Baumgartner WA: Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest. Ann Thorac Surg; 2010 Feb;89(2):440-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest.
  • BACKGROUND: Prolonged hypothermic circulatory arrest results in neuronal cell death and neurologic injury.
  • We have previously shown that hypothermic circulatory arrest causes both neuronal apoptosis and necrosis in a canine model.
  • This study was undertaken to determine whether glutamate receptor antagonism reduces nitric oxide formation and neuronal apoptosis after hypothermic circulatory arrest.
  • METHODS: Sixteen hound dogs underwent 2 hours of circulatory arrest at 18 degrees C and were sacrificed after 8 hours.
  • Group 1 (n = 8) was treated with MK-801, 0.75 mg/kg intravenously prior to arrest followed by 75 microg/kg/hour infusion.
  • However, MK-801 significantly reduced intracerebral glycine and citrulline levels compared with hypothermic circulatory arrest controls.
  • We provide evidence that glutamate excitotoxicity mediates neuronal apoptosis in addition to necrosis after hypothermic circulatory arrest.
  • Clinical glutamate receptor antagonists may have therapeutic benefits in ameliorating both types of neurologic injury after hypothermic circulatory arrest.

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20103318.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS031238-07; United States / NINDS NIH HHS / NS / R37 NS031238; United States / NINDS NIH HHS / NS / 2R01NS31238-05; United States / NINDS NIH HHS / NS / R01 NS031238-07; United States / NINDS NIH HHS / NS / R01 NS031238
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Excitatory Amino Acid Antagonists; 0 / Excitatory Amino Acids; 29VT07BGDA / Citrulline; 31C4KY9ESH / Nitric Oxide; 3KX376GY7L / Glutamic Acid; 6LR8C1B66Q / Dizocilpine Maleate; TE7660XO1C / Glycine
  • [Other-IDs] NLM/ NIHMS267990; NLM/ PMC3076934
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50. Gorji R, Wang J, Eller JL, Holsapple J: Deep hypothermic circulatory arrest for treatment of renal carcinoma. J Clin Anesth; 2009 May;21(3):217-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep hypothermic circulatory arrest for treatment of renal carcinoma.
  • The case of a 67-year-old woman with multiple medical problems who presented for resection of a metastatic renal cell carcinoma involving the posterior fossa, is presented.
  • Anesthetic management of the patient, who suffered metastasis to the brain, and who required deep hypothermic circulatory arrest, is discussed.
  • [MeSH-major] Carcinoma, Renal Cell / therapy. Circulatory Arrest, Deep Hypothermia Induced / methods. Kidney Neoplasms / therapy

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  • (PMID = 19464618.001).
  • [ISSN] 1873-4529
  • [Journal-full-title] Journal of clinical anesthesia
  • [ISO-abbreviation] J Clin Anesth
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Bioulac-Sage P, Laumonier H, Couchy G, Le Bail B, Sa Cunha A, Rullier A, Laurent C, Blanc JF, Cubel G, Trillaud H, Zucman-Rossi J, Balabaud C, Saric J: Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. Hepatology; 2009 Aug;50(2):481-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience.
  • We took advantage of the reported genotype/phenotype classification to analyze our surgical series of hepatocellular adenoma (HCA).
  • We identified 46 HNF1alpha-inactivated HCAs (44 women), 63 inflammatory HCAs (IHCA, 53 women) of which nine were also beta-catenin-activated, and seven beta-catenin-activated HCAs (all women); six additional cases had no known phenotypic marker and six others could not be phenotypically analyzed.
  • Twenty-three of 128 HCAs showed bleeding.
  • Steatosis (tumor), microadenomas (resected specimen), and additional benign nodules were more frequently observed in HNF1alpha-inactivated HCAs (P < 0.01) than in IHCAs.
  • Body mass index > 25, peliosis (tumor), and steatosis in background liver were more frequent in IHCA (P < 0.01).
  • After complete resection, new HCAs in the centimetric range were more frequently found during follow-up (>1 year) in HNF1alpha-inactivated HCA.
  • After incomplete resection (HCA left in nonresected liver), the majority of HCA remained stable in the two main groups and even sometimes regressed.
  • Six patients of 128 developed hepatocellular carcinoma (HCC) (all were beta-catenin-activated, whether inflammatory or not).
  • CONCLUSION: There were noticeable clinical differences between HNF1alpha-inactivated HCA and IHCA; there was no increased risk of bleeding or HCC related to the number of HCAs; beta-catenin-activated HCAs are at higher risk of HCC.
  • As a consequence, we believe that management of HCA needs to be adapted to the phenotype of these tumors.
  • [MeSH-major] Adenoma, Liver Cell / classification. Liver Neoplasms / classification

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  • (PMID = 19585623.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fatty Acid-Binding Proteins; 0 / Hepatocyte Nuclear Factor 1-alpha; 0 / Serum Amyloid A Protein; 0 / beta Catenin; 9007-41-4 / C-Reactive Protein
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52. Reece TB, Tribble CG, Peeler BB, Singh RR, Gazoni LM, Kron IL, Kern JA: Elective hypothermic circulatory arrest to address aortic pathology is safe for the elderly. J Card Surg; 2009 May-Jun;24(3):240-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Elective hypothermic circulatory arrest to address aortic pathology is safe for the elderly.
  • BACKGROUND: Due to assumptions of excessive risk, hypothermic circulatory arrest (HCA) has been considered prohibitive in elderly patients.
  • However, as more elderly patients are referred for assessment of difficult aortic valve, ascending aorta, and aortic arch pathology, the risk of HCA in these patients needs to be addressed.
  • We hypothesized that the use of HCA would not increase mortality or complications in elderly patients compared to younger counterparts.
  • METHODS: We retrospectively reviewed the charts of adult patients who underwent elective HCA between January 1995 and June 2007.
  • CONCLUSION: In this study, elderly patients faired well with HCA compared to younger patients.
  • These data suggest that the use of HCA is safe in selected elderly patients.
  • [MeSH-major] Aortic Diseases / surgery. Heart Arrest, Induced / methods. Hypothermia, Induced / methods. Vascular Surgical Procedures / methods

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  • (PMID = 19438774.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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53. Shum KC, Chen F, Li SL, Wang J, But PP, Shaw PC: Authentication of Radix Aucklandiae and its substitutes by GC-MS and hierarchical clustering analysis. J Sep Sci; 2007 Dec;30(18):3233-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Authentication of Radix Aucklandiae and its substitutes by GC-MS and hierarchical clustering analysis.
  • In addition, hierarchical clustering analysis was used to compare the similarities of these chemical profiles.
  • It was found that all the samples of A. lappa have similar chemical profiles and were clustered into one group, while the samples of Radix Vladimiriae, Radix Inulae, and Radix Aristolochiae were clustered into their own independent groups, respectively, suggesting that together with hierarchical clustering analysis, chemical profiles of essential oils generated by GC-MS could objectively discriminate Radix Aucklandiae from its common substitutes.
  • [MeSH-minor] Cluster Analysis. Reproducibility of Results

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  • (PMID = 18004716.001).
  • [ISSN] 1615-9306
  • [Journal-full-title] Journal of separation science
  • [ISO-abbreviation] J Sep Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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54. Toyama M, Matsumura Y, Tamenishi A, Okamoto H: Safety of mild hypothermic circulatory arrest with selective cerebral perfusion. Asian Cardiovasc Thorac Ann; 2009 Oct;17(5):500-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Safety of mild hypothermic circulatory arrest with selective cerebral perfusion.
  • Although hypothermic circulatory arrest with antegrade selective cerebral perfusion is used for cerebral protection, optimal perfusion characteristics are still unclear.
  • Between May 2006 and March 2008, 26 patients (mean age, 68.9 years; 14 males) underwent thoracic aortic repair with mild hypothermic circulatory arrest (34.3 degrees C +/- 1.9 degrees C) and antegrade selective cerebral perfusion (30 degrees C) for various indications including 16 acute type A aortic dissections.
  • Cardiopulmonary bypass time was 209 +/- 61 min, cardiac ischemic time was 141 +/- 45 min, cerebral perfusion time was 81 +/- 67 min, and lower body circulatory arrest time was 65 +/- 22 min.
  • There was 1 (3.8%) hospital death due to rupture of a residual descending thoracic aneurysm.
  • Mild hypothermic circulatory arrest with antegrade selective cerebral perfusion could be performed safely in our patient population.
  • [MeSH-major] Aorta, Thoracic / surgery. Aortic Diseases / surgery. Blood Vessel Prosthesis Implantation. Cerebrovascular Circulation. Heart Arrest, Induced / methods. Hypothermia, Induced. Perfusion

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  • [CommentIn] Asian Cardiovasc Thorac Ann. 2010 Oct;18(5):495 [20947611.001]
  • (PMID = 19917793.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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55. Chalabaev S, Turlin E, Bay S, Ganneau C, Brito-Fravallo E, Charles JF, Danchin A, Biville F: Cinnamic acid, an autoinducer of its own biosynthesis, is processed via Hca enzymes in Photorhabdus luminescens. Appl Environ Microbiol; 2008 Mar;74(6):1717-25
EAWAG Biocatalysis/Biodegradation Database. protein interactions/pathways - EAWAG Biocatalysis/Biodegradation Database .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cinnamic acid, an autoinducer of its own biosynthesis, is processed via Hca enzymes in Photorhabdus luminescens.
  • Photorhabdus luminescens, an entomopathogenic bacterium and nematode symbiont, has homologues of the Hca and Mhp enzymes.
  • Hca dioxygenase is involved in this degradation pathway. P. luminescens synthesizes CA from phenylalanine via a phenylalanine ammonia-lyase (PAL) and degrades it via the not-yet-characterized biosynthetic pathway of 3,5-dihydroxy-4-isopropylstilbene (ST) antibiotic.
  • Hca dioxygenase is involved in the consumption of endogenous CA but is not required for ST production.
  • This suggests that CA is consumed via at least two separate pathways in P. luminescens: the biosynthesis of ST and a pathway involving the Hca and Mhp enzymes.

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  • (PMID = 18245247.001).
  • [ISSN] 1098-5336
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Cinnamates; 0 / Phenylpropionates; EC 4.3.1.24 / Phenylalanine Ammonia-Lyase; U14A832J8D / cinnamic acid
  • [Other-IDs] NLM/ PMC2268303
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56. Numata S, Thomson DS, Seah P, Singh T: Simplified cerebral protection using unilateral antegrade cerebral perfusion and moderate hypothermic circulatory arrest. Heart Lung Circ; 2009 Oct;18(5):334-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simplified cerebral protection using unilateral antegrade cerebral perfusion and moderate hypothermic circulatory arrest.
  • BACKGROUND: Antegrade cerebral perfusion is one of the most reliable methods of organ protection during hypothermic circulatory arrest for aortic arch surgery.
  • METHODS: Between January 2005 and August 2008, 21 patients underwent aortic arch surgery with unilateral antegrade selective cerebral perfusion through the brachiocephalic artery and moderate hypothermic circulatory arrest.
  • Eight out of 20 patients had circulatory arrest at 28 degrees C and their mean circulatory arrest time was 22.8+/-4.7 (16-32)min.
  • DISCUSSION: The mortality and neurological outcomes of aortic surgery using unilateral antegrade cerebral perfusion with moderate hypothermic circulatory arrest produced satisfactory results.
  • [MeSH-major] Aorta, Thoracic / surgery. Cardiopulmonary Bypass / methods. Circulatory Arrest, Deep Hypothermia Induced / methods

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  • (PMID = 19682949.001).
  • [ISSN] 1444-2892
  • [Journal-full-title] Heart, lung & circulation
  • [ISO-abbreviation] Heart Lung Circ
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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57. Camboni D, Philipp A, Schebesch KM, Schmid C: Accuracy of core temperature measurement in deep hypothermic circulatory arrest. Interact Cardiovasc Thorac Surg; 2008 Oct;7(5):922-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accuracy of core temperature measurement in deep hypothermic circulatory arrest.
  • Therefore, we simultaneously measured brain and core temperatures during neurosurgical interventions in hypothermic circulatory arrest to determine its accuracy.
  • Between 1994 and May 2007, 26 patients (12 female, mean age 46+/-14 years), with complex intracranial aneurysms, underwent resection or clipping applying closed chest cardiopulmonary bypass and hypothermic circulatory arrest via inguinal cannulation.
  • Mean cardiopulmonary bypass time was 147+/-39 min, mean circulatory arrest time was 28+/-8 min.
  • [MeSH-major] Body Temperature. Brain / surgery. Circulatory Arrest, Deep Hypothermia Induced. Intracranial Aneurysm / surgery. Monitoring, Intraoperative / methods

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  • (PMID = 18658167.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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58. Mack WJ, Ducruet AF, Angevine PD, Komotar RJ, Shrebnick DB, Edwards NM, Smith CR, Heyer EJ, Monyero L, Connolly ES Jr, Solomon RA: Deep hypothermic circulatory arrest for complex cerebral aneurysms: lessons learned. Neurosurgery; 2007 May;60(5):815-27; discussion 815-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep hypothermic circulatory arrest for complex cerebral aneurysms: lessons learned.
  • OBJECTIVE: Deep hypothermic circulatory arrest is a useful adjunct for treating complex aneurysms.
  • We present 66 patients with intracranial aneurysms who underwent surgical clipping under deep hypothermic arrest and attempt to identify patients well-suited for this procedure.
  • RESULTS: Patient age and the duration of cardiac arrest were independent predictors of early clinical outcome (P < 0.05).
  • Circulatory arrest should not exceed 30 minutes.
  • CONCLUSION: Hypothermic circulatory arrest is a useful technique for neuroprotection during the clipping of complex cerebral aneurysms.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced / methods. Intracranial Aneurysm / surgery

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  • [ReprintIn] Neurosurgery. 2008 Jun;62(6 Suppl 3):1311-23 [18695551.001]
  • (PMID = 17460516.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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59. Yannopoulos FS, Mäkelä T, Niemelä E, Tuominen H, Lepola P, Alestalo K, Kaakinen H, Kiviluoma K, Anttila V, Juvonen T: Improved cerebral recovery from hypothermic circulatory arrest after remote ischemic preconditioning. Ann Thorac Surg; 2010 Jul;90(1):182-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Improved cerebral recovery from hypothermic circulatory arrest after remote ischemic preconditioning.
  • We hypothesized that remote ischemic preconditioning might also improve the recovery from hypothermic circulatory arrest (HCA).
  • METHODS: Twenty-four juvenile pigs underwent 60 minutes of HCA at 18 degrees C with either transient right hind leg ischemic preconditioning or no ischemic preconditioning.
  • Cerebral extracellular glucose and glycerol content rose significantly immediately after HCA in the control group compared with the remote ischemic preconditioning group, and significantly higher lactate concentrations were measured in the control group at 5 and 6 hours after reperfusion, indicating a difference in cerebral metabolism.
  • CONCLUSIONS: Our data imply that remote ischemic preconditioning improves the recovery from HCA.
  • It provides a faster recovery of cortical neuronal activity and protection against potential oxygen radical-mediated ischemia damage during and after HCA.
  • [MeSH-major] Brain / metabolism. Brain Ischemia / prevention & control. Circulatory Arrest, Deep Hypothermia Induced. Hindlimb / blood supply. Ischemic Preconditioning / methods

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  • [Copyright] Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ann Thorac Surg. 2010 Jul;90(1):188-9 [20609772.001]
  • (PMID = 20609771.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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60. Kulik A, Castner CF, Kouchoukos NT: Replacement of the descending thoracic aorta: contemporary outcomes using hypothermic circulatory arrest. J Thorac Cardiovasc Surg; 2010 Feb;139(2):249-55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Replacement of the descending thoracic aorta: contemporary outcomes using hypothermic circulatory arrest.
  • We evaluated our experience with replacement of the descending thoracic aorta using hypothermic circulatory arrest.
  • METHODS: From May 1989 to August 2008, 151 patients (mean age 62 +/- 15 years) had descending thoracic aorta replacement using cardiopulmonary bypass and hypothermic circulatory arrest.
  • RESULTS: The mean durations of bypass and circulatory arrest were 107 +/- 34 and 32 +/- 9 minutes, respectively.
  • CONCLUSIONS: Cardiopulmonary bypass with hypothermic circulatory arrest can be safely used for replacement of the descending thoracic aorta.

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  • [Copyright] 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
  • (PMID = 19969311.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Wang LM, Chen X, Shi KH, Xu M, Jiang YS, Xiao LQ, Zhao HP, Liu PS, Wang R, Zhen L: [Aortic arch operation under deep hypothermic circulatory arrest]. Zhonghua Yi Xue Za Zhi; 2009 Jan 6;89(1):45-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Aortic arch operation under deep hypothermic circulatory arrest].
  • OBJECTIVE: To summarize the surgical experience of aortic arch operation under deep hypothermic circulatory arrest.
  • METHODS: 22 patients suffering from aortic dissection or descending aorta aneurysm with the involvement of aortic arch received operation under deep hypothermic circulatory arrest.
  • One patient had aortic dissection rupture before operation leading to cardiac tamponade, acute inferior myocardial infarction, and cardiac arrest.
  • After operation, the patient had severe right heart failure and died 16 hours later.
  • Deep hypothermic circulatory arrest with selective cerebral perfusion facilitates complicated aortic arch operation, resulting in a reduction of mortality and morbidity for arch aneurysms or dissection.
  • [MeSH-major] Aorta, Thoracic / surgery. Aortic Aneurysm / surgery. Circulatory Arrest, Deep Hypothermia Induced

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  • (PMID = 19489244.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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62. Kunihara T, Tscholl D, Langer F, Heinz G, Sata F, Schäfers HJ: Cognitive brain function after hypothermic circulatory arrest assessed by cognitive P300 evoked potentials. Eur J Cardiothorac Surg; 2007 Sep;32(3):507-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cognitive brain function after hypothermic circulatory arrest assessed by cognitive P300 evoked potentials.
  • BACKGROUND: The role of hypothermic circulatory arrest (HCA) in cardiovascular surgery is controversial and assumed to result in neurocognitive dysfunction that is not always detected by standard clinical observation.
  • We assessed cognitive P300 visual evoked potentials (P300) in patients undergoing either HCA or coronary artery bypass grafting (CABG) to elucidate whether HCA was associated with postoperative cognitive decline.
  • METHODS: Thirteen patients undergoing either aortic arch replacement (n=4) or pulmonary thromboendarterectomy (n=9) using HCA (mean: 28+/-11 min, 22+/-2 degrees C) were studied.
  • Preoperatively, the HCA group could not concentrate on target stimulus as well as the control group in frontal leads (CI(AUC) and CI(Cv) were lower in HCA group than in control group).
  • However, the HCA group could concentrate on target stimulus better than the control group postoperatively because postoperative CI(AUC) (pre-operation: 1.1+/-0.5 to post-operation: 1.7+/-0.4, P=.02) and CI(Cv) (1.1+/-0.4 to 1.6+/-0.4, P=.01) were significantly improved in the HCA group, whereas these were significantly impaired in the control group (CI(AUC): 1.6+/-0.6 to 1.3+/-0.4, P=.03, CI(Cv): 1.5+/-0.5 to 1.2+/-0.3, P<.01).
  • Postoperative CI(Ct) in the HCA group were significantly impaired in all leads.
  • The duration of HCA did not correlate with any values of postoperative P300.
  • Postoperative improvement of CI(AUC) and CI(Cv) in Fz lead were found in 85 and 69% in the HCA group and 23 and 23% in the control group, respectively (CI(AUC): P<.01, CI(Cv): P<.05).
  • CONCLUSIONS: P300 detected no significant neurocognitive impairment due to the relatively brief period of HCA (approximately 28 min).
  • [MeSH-minor] Aged. Analysis of Variance. Area Under Curve. Biomarkers / blood. Brain Damage, Chronic / etiology. Endarterectomy / methods. Heart Arrest, Induced. Humans. Hypothermia, Induced. Male. Middle Aged. Neuropsychological Tests. Postoperative Complications / etiology. Thrombosis

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  • (PMID = 17627831.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers
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63. Mack WJ, Ducruet AF, Angevine PD, Komotar RJ, Shrebnick DB, Edwards NM, Smith CR, Heyer EJ, Monyero L, Connolly ES Jr, Solomon RA: Deep hypothermic circulatory arrest for complex cerebral aneurysms: lessons learned. Neurosurgery; 2008 Jun;62(6 Suppl 3):1311-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep hypothermic circulatory arrest for complex cerebral aneurysms: lessons learned.
  • OBJECTIVE: Deep hypothermic circulatory arrest is a useful adjunct for treating complex aneurysms.
  • We present 66 patients with intracranial aneurysms who underwent surgical clipping under deep hypothermic arrest and attempt to identify patients well-suited for this procedure.
  • RESULTS: Patient age and the duration of cardiac arrest were independent predictors of early clinical outcome (P < 0.05).
  • Circulatory arrest should not exceed 30 minutes.
  • CONCLUSION: Hypothermic circulatory arrest is a useful technique for neuroprotection during the clipping of complex cerebral aneurysms.

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  • [ReprintOf] Neurosurgery. 2007 May;60(5):815-27; discussion 815-27 [17460516.001]
  • (PMID = 18695551.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Dietrich CF, Schuessler G, Trojan J, Fellbaum C, Ignee A: Differentiation of focal nodular hyperplasia and hepatocellular adenoma by contrast-enhanced ultrasound. Br J Radiol; 2005 Aug;78(932):704-7
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  • [Title] Differentiation of focal nodular hyperplasia and hepatocellular adenoma by contrast-enhanced ultrasound.
  • Non-invasive differentiation of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) is difficult.
  • The aim of this study was to assess the accuracy of contrast-enhanced phase inversion ultrasound to differentiate between histologically proven FNH and HCA, analysing the arterial and (early) portal venous phase.
  • 32 patients with histological proven FNH (n=24) or HCA (n=8) have been included in this prospective study.
  • The contrast enhancing tumour characteristics were evaluated during the hepatic arterial (starting 8-22 s) and early portal venous phase (starting 12-30 s).
  • The image analysis was performed by three examiners.
  • Homogeneous enhancement was detected during the hepatic arterial phase in all eight patients with HCA.
  • In contrast, after homogeneous enhancement during hepatic arterial phase, no enhancement during hepatic portal venous phase was detected in patients with hepatocellular adenoma.
  • Therefore, this technique might improve the functional characterization of benign hypervascular focal liver lesions.
  • [MeSH-major] Adenoma, Liver Cell / ultrasonography. Focal Nodular Hyperplasia / ultrasonography. Liver Neoplasms / ultrasonography
  • [MeSH-minor] Adolescent. Adult. Contrast Media. Diagnosis, Differential. Female. Humans. Image Enhancement / methods. Male. Middle Aged. Phospholipids. Sulfur Hexafluoride. Ultrasonography, Doppler, Color

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  • (PMID = 16046421.001).
  • [ISSN] 0007-1285
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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65. Jeannot E, Mellottee L, Bioulac-Sage P, Balabaud C, Scoazec JY, Tran Van Nhieu J, Bacq Y, Michalak S, Buob D, Groupe d'étude Génétique des Tumeurs Hépatiques (INSERM Network), Laurent-Puig P, Rusyn I, Zucman-Rossi J: Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage. Diabetes; 2010 Jul;59(7):1836-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage.
  • A subtype of hepatocellular adenoma (HCA) is also caused by biallelic somatic HNF1A mutations (H-HCA), and rare HCA may be related to MODY3.
  • To better understand a relationship between the development of MODY3 and HCA, we compared both germline and somatic spectra of HNF1A mutations.
  • RESEARCH DESIGN AND METHODS: We compared 151 somatic HNF1A mutations in HCA with 364 germline mutations described in MODY3.
  • We searched for genotoxic and oxidative stress features in HCA and surrounding liver tissue.
  • In HCA, we identified a specific hot spot at codon 206, nonsense and frameshift mutations mainly in the NH(2)-terminal part, and almost all amino acid substitutions were restricted to the POU-H domain.
  • However, no features of oxidative stress were observed in the nontumor liver tissue.
  • Finally, in a few MODY3 patients with HNF1A germline mutation leading to amino acid substitutions outside the POU-H domain, we identified a different subtype of HCA either with a gp130 and/or CTNNB1 activating mutation.
  • CONCLUSIONS: Germline HNF1A mutations could be associated with different molecular subtypes of HCA.
  • H-HCA showed mutations profoundly inactivating hepatocyte nuclear factor-1alpha function; they are associated with a genotoxic signature suggesting a specific toxicant exposure that could be associated with genetic predisposition.

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  • (PMID = 20393147.001).
  • [ISSN] 1939-327X
  • [Journal-full-title] Diabetes
  • [ISO-abbreviation] Diabetes
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES010126; United States / NIEHS NIH HHS / ES / R01-ES-15241; United States / NIEHS NIH HHS / ES / R01 ES015241; United States / NIAAA NIH HHS / AA / R01-AA-16258; United States / NIAAA NIH HHS / AA / R01 AA016258
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HNF1A protein, human; 0 / Hepatocyte Nuclear Factor 1-alpha
  • [Other-IDs] NLM/ PMC2889786
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66. Dian-San S, Xiang-Rui W, Yongjun Z, Yan-Hua Z: Low hematocrit worsens cerebral injury after prolonged hypothermic circulatory arrest in rats. Can J Anaesth; 2006 Dec;53(12):1220-9
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  • [Title] Low hematocrit worsens cerebral injury after prolonged hypothermic circulatory arrest in rats.
  • PURPOSE: This study tests the hypothesis that low hematocrit (Hct) worsens cerebral injury after prolonged hypothermic circulatory arrest (HCA) in rats, and the mechanism involves variable expression of the genes C-Fos, Bcl-2 and Bax.
  • METHODS: A rat HCA model was developed, and 40 animals were randomly assigned to four groups: Sham (sham) group, or Hct groups of Hct 10%, Hct 20% and Hct 30%.
  • After 90 min of HCA at 18 degrees C, physiologic variables were recorded and brain morphological changes were evaluated with light and electron microscopy.
  • Expressions of C-Fos, Bcl-2, Bax in various brain areas were measured by the reverse transcriptase polymerase chain reaction and standard immunohistochemistry techniques.
  • Mean mitochondrial injury scores were greatest at lower Hct levels, while the expression of C-Fos and Bax were highest in the Hct 10% group and lowest in the Hct30% group (P < 0.05).
  • CONCLUSION: Low Hct worsens cerebral injury after prolonged HCA and CPB in rats, which may relate in part to the variable expression of the genes C-Fos, Bcl-2 and Bax.
  • [MeSH-major] Brain / pathology. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Hematocrit. Hemodilution / adverse effects

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  • [CommentIn] Can J Anaesth. 2006 Dec;53(12):1171-4 [17142649.001]
  • (PMID = 17142657.001).
  • [ISSN] 1496-8975
  • [Journal-full-title] Canadian journal of anaesthesia = Journal canadien d'anesthésie
  • [ISO-abbreviation] Can J Anaesth
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Proto-Oncogene Proteins c-fos; 0 / bcl-2-Associated X Protein
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67. Givehchian M, Beschorner R, Ehmann C, Frauenlob L, Morgalla M, Hashemi B, Ziemer G, Scheule AM: Neuroprotective effects of erythropoietin during deep hypothermic circulatory arrest. Eur J Cardiothorac Surg; 2010 Mar;37(3):662-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroprotective effects of erythropoietin during deep hypothermic circulatory arrest.
  • Using a surviving porcine model, this study evaluates whether systemic treatment with erythropoietin induces brain protection in deep hypothermic circulatory arrest (DHCA).
  • CONCLUSION: These results suggest some beneficial neuroprotective effects of erythropoietin in this model of global brain ischaemia induced by 1h of hypothermic circulatory arrest.
  • [MeSH-major] Erythropoietin / therapeutic use. Heart Arrest, Induced / adverse effects. Hypoxia-Ischemia, Brain / prevention & control. Neuroprotective Agents / therapeutic use
  • [MeSH-minor] Animals. Brain / metabolism. Disease Models, Animal. Drug Evaluation, Preclinical. Hemodynamics / physiology. Hypothermia, Induced / adverse effects. Intracranial Pressure / drug effects. Oxygen Consumption / drug effects. Perioperative Care / methods. Random Allocation. Recombinant Proteins. Sus scrofa

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  • [Copyright] Copyright (c) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
  • (PMID = 19766506.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neuroprotective Agents; 0 / Recombinant Proteins; 11096-26-7 / Erythropoietin
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68. Patel HJ, Shillingford MS, Mihalik S, Proctor MC, Deeb GM: Resection of the descending thoracic aorta: outcomes after use of hypothermic circulatory arrest. Ann Thorac Surg; 2006 Jul;82(1):90-5; discussion 95-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resection of the descending thoracic aorta: outcomes after use of hypothermic circulatory arrest.
  • BACKGROUND: Use of hypothermic circulatory arrest (HCA) for operations on the descending thoracic aorta is controversial.
  • While deep hypothermia may provide better end-organ and spinal cord function, prolonged cardiopulmonary bypass and circulatory arrest may increase morbidity.
  • This study assessed outcomes after use of HCA for descending thoracic aortic resection in a large cohort of consecutive patients.
  • METHODS: Hypothermic circulatory arrest was utilized if arch or extensive descending thoracic aortic resection was required, or if aortic pathology precluded cross-clamping.
  • Diagnosis included fusiform (41.2%) or saccular aneurysm (10.7%) and acute (4.6%) or chronic (38.9%) dissection.
  • The proximal anastomosis was performed with total body HCA while the distal anastomosis was constructed with lower body HCA only (duration upper body HCA 33.7 +/- 8.0 minutes; total duration lower body HCA 71.3 +/- 24.2 minutes).
  • Independent predictors of a composite endpoint of death, stroke, permanent paralysis, or dialysis included duration of lower body HCA (p = 0.03) and major postoperative infection (p = 0.003).
  • CONCLUSIONS: Adjunctive use of deep hypothermic circulatory arrest for descending thoracic aortic resection affords excellent preservation of end-organ and spinal cord function with acceptable rates of mortality and significant morbidity.
  • [MeSH-major] Aneurysm, Dissecting / surgery. Aorta, Thoracic / surgery. Aortic Aneurysm, Thoracic / surgery. Circulatory Arrest, Deep Hypothermia Induced
  • [MeSH-minor] Acute Kidney Injury / epidemiology. Acute Kidney Injury / etiology. Acute Kidney Injury / therapy. Aged. Anastomosis, Surgical. Cardiopulmonary Bypass / adverse effects. Cohort Studies. Female. Humans. Male. Middle Aged. Paraplegia / epidemiology. Paraplegia / etiology. Postoperative Complications / epidemiology. Postoperative Complications / mortality. Renal Dialysis. Spinal Cord Ischemia / epidemiology. Spinal Cord Ischemia / etiology. Stroke / epidemiology. Stroke / etiology. Survival Analysis. Treatment Outcome

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  • (PMID = 16798196.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
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69. Dahlbacka S, Mäkelä J, Kaakinen T, Alaoja H, Heikkinen J, Laurila P, Kiviluoma K, Salomäki T, Tuominen H, Ohtonen P, Lepola P, Biancari F, Juvonen T: Propofol is associated with impaired brain metabolism during hypothermic circulatory arrest: an experimental microdialysis study. Heart Surg Forum; 2006;9(4):E710-8; discussion E718
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  • [Title] Propofol is associated with impaired brain metabolism during hypothermic circulatory arrest: an experimental microdialysis study.
  • Efficient brain perfusion and tissue oxygenation during cardiopulmonary bypass (CPB) is essential in surgery requiring hypothermic circulatory arrest (HCA).
  • The effects of propofol on brain metabolism are reported in a surviving porcine model of HCA.
  • METHODS: Twenty female juvenile pigs undergoing 75 minutes of HCA at a brain temperature of 18 degrees C were assigned to either propofol- or isoflurane anesthesia combined with alpha-stat perfusion strategy during CPB cooling and rewarming.
  • Brain microdialysis analysis was used for determination of brain metabolism, and tissue oxygen partial pressure and intracranial pressures were also followed-up until 8 hours postoperatively.
  • CONCLUSIONS: Anesthesia with propofol as compared with isoflurane is associated with impaired brain metabolism during experimental HCA.
  • [MeSH-major] Brain / drug effects. Brain / metabolism. Brain Diseases, Metabolic / chemically induced. Brain Diseases, Metabolic / metabolism. Circulatory Arrest, Deep Hypothermia Induced. Propofol / adverse effects

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  • (PMID = 16844626.001).
  • [ISSN] 1522-6662
  • [Journal-full-title] The heart surgery forum
  • [ISO-abbreviation] Heart Surg Forum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Intravenous; YI7VU623SF / Propofol
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70. Van Putte BP, Bantal N, Snijder R, Morshuis WJ, Van Boven WJ: Acute massive pulmonary embolism treated by thrombo-embolectomy using intermittent deep hypothermic circulatory arrest. Interact Cardiovasc Thorac Surg; 2008 May;7(3):412-3
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  • [Title] Acute massive pulmonary embolism treated by thrombo-embolectomy using intermittent deep hypothermic circulatory arrest.
  • Usually, urgent thrombo-embolectomy is performed using double venous cannulation without circulatory arrest.
  • In order to achieve complete thrombo-embolectomy, intermittent deep hypothermic circulatory arrest was performed.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced. Embolectomy. Pulmonary Embolism / surgery
  • [MeSH-minor] Acute Disease. Adult. Anticoagulants / therapeutic use. Emergency Treatment. Female. Humans. Severity of Illness Index. Tomography, X-Ray Computed. Treatment Outcome

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  • [CommentIn] Interact Cardiovasc Thorac Surg. 2008 May;7(3):413-4 [18495708.001]
  • (PMID = 18349149.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticoagulants
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71. Singal RK, Docking LM, Girling LG, Graham MR, Nickerson PW, McManus BM, Magil AB, Walker EK, Warrian RK, Cheang MS, Mutch WA: Biologically variable bypass reduces enzymuria after deep hypothermic circulatory arrest. Ann Thorac Surg; 2006 Oct;82(4):1480-8
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  • [Title] Biologically variable bypass reduces enzymuria after deep hypothermic circulatory arrest.
  • BACKGROUND: Renal injury is common after open-heart surgery.
  • We hypothesized BVP would decrease renal injury after deep hypothermic circulatory arrest.
  • Additional pigs had NP for a similar time as above, but without circulatory arrest (n = 3), or were sham-treated without bypass (n = 3).
  • RESULTS: Urine output at 1 hour after arrest was 250 +/- 129 mL with BVP versus 114 +/- 66 mL with NP (p < 0.02).
  • All three renal enzyme markers were higher with NP after arrest compared with BVP.
  • In animals on bypass without arrest or those sham-treated, no elevations were seen in renal enzymes.
  • This strategy could potentially shorten bypass duration and may decrease renal tubular injury with deep hypothermic circulatory arrest.
  • [MeSH-major] Acute Kidney Injury / prevention & control. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Perfusion / methods. Pulsatile Flow / physiology

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  • [CommentIn] Ann Thorac Surg. 2006 Oct;82(4):1488 [16996958.001]
  • (PMID = 16996957.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; EC 2.3.2.2 / gamma-Glutamyltransferase; EC 2.5.1.18 / Glutathione Transferase; EC 3.1.3.1 / Alkaline Phosphatase
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72. Cui X, Song B, Hou L, Wei Z, Tang J: High expression of osteoglycin decreases the metastatic capability of mouse hepatocarcinoma Hca-F cells to lymph nodes. Acta Biochim Biophys Sin (Shanghai); 2008 Apr;40(4):349-55
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  • [Title] High expression of osteoglycin decreases the metastatic capability of mouse hepatocarcinoma Hca-F cells to lymph nodes.
  • Osteoglycin, one of the matrix molecules, belongs to the small leucine-rich proteoglycan gene family and might play important roles in cell growth and differentiation and in pathological processes such as fibrosis and cancer growth.
  • In this study, a eukaryotic expression plasmid pIRESpuro3 osteoglycin(+) was constructed and transfected into mouse hepatocarcinoma Hca-F cells to evaluate the contribution of osteoglycin to the malignant behavior of Hca-F.
  • It was found that Hca-F cells transfected with pIRESpuro3 osteoglycin(+) showed significantly decreased potential for both migration and invasion.
  • Furthermore, Hca-F cells transfected with osteoglycin showed decreased metastatic potential to peripheral lymph nodes.
  • However, proliferation potential and adhesive capacity of Hca-F cells to different protein substrates were not influenced by osteoglycin transfection.
  • In summary, high expression of osteoglycin decreases the metastatic capability of Hca-F to lymph nodes.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / secondary. Gene Expression Regulation, Neoplastic. Liver Neoplasms / metabolism. Liver Neoplasms / secondary. Lymph Nodes / metabolism
  • [MeSH-minor] Animals. Cell Line, Tumor. Lymphatic Metastasis. Male. Mice. Mice, Inbred Strains. Up-Regulation

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  • (PMID = 18401533.001).
  • [ISSN] 1745-7270
  • [Journal-full-title] Acta biochimica et biophysica Sinica
  • [ISO-abbreviation] Acta Biochim. Biophys. Sin. (Shanghai)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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73. Han QQ, Xu ZY, Zhang BR, Xu JB, Han L, He B, Zhao TJ: [Impact of different brain protection techniques upon postoperative temporary neurological dysfunction in aortic surgery with the aid of deep hypothermic circulatory arrest]. Zhonghua Wai Ke Za Zhi; 2007 Mar 15;45(6):419-22
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  • [Title] [Impact of different brain protection techniques upon postoperative temporary neurological dysfunction in aortic surgery with the aid of deep hypothermic circulatory arrest].
  • OBJECTIVE: To assess impact of different brain protection techniques upon postoperative temporary neurological dysfunction in aortic surgery with the aid of deep hypothermic circulatory arrest.
  • METHODS: From January 2003 to December 2005, 78 patients who met the inclusion criteria entered the present cohort, 43 of whom were under the aid of deep hypothermic circulatory arrest plus retrograde cerebral perfusion (RCP group) and the other 35 under deep hypothermic circulatory arrest plus selective antegrade cerebral perfusion (SCP group).
  • The impact of duration of deep hypothermic circulatory arrest upon the postoperative temporary neurological dysfunction was also evaluated.
  • And long duration of deep hypothermic circulatory arrest (more than 50 min) has a negative impact on the postoperative temporary neurological dysfunction rate.
  • CONCLUSIONS: Applying selective antegrade cerebral perfusion as the brain protection technique and shortening the duration of deep hypothermic circulatory arrest can reduce the incidence of temporary neurological dysfunction and preserve cerebral function more effectively.
  • [MeSH-major] Aorta / surgery. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Nervous System Diseases / prevention & control. Postoperative Complications / prevention & control

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  • (PMID = 17537332.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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74. Chen ZM, Crone KG, Watson MA, Pfeifer JD, Wang HL: Identification of a unique gene expression signature that differentiates hepatocellular adenoma from well-differentiated hepatocellular carcinoma. Am J Surg Pathol; 2005 Dec;29(12):1600-8
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  • [Title] Identification of a unique gene expression signature that differentiates hepatocellular adenoma from well-differentiated hepatocellular carcinoma.
  • It is often difficult to distinguish hepatocellular adenoma (HCA) from well-differentiated hepatocellular carcinoma (WDHCC) when limited tissue from a needle biopsy is evaluated.
  • The aim of this study was to identify gene expression patterns that can distinguish HCA from WDHCC, with the ultimate goal of discovering novel diagnostic markers.
  • Gene expression profile analysis was performed using Affymetrix U133Plus2 GeneChip microarrays on RNA isolated from frozen tissue of 6 HCA and 8 WDHCC specimens.
  • Statistical analysis of microarray data identified 63 genes whose expression levels were significantly different between HCA and WDHCC.
  • These included 57 genes overexpressed by HCA and 6 overexpressed by WDHCC.
  • Eight genes were chosen for further analysis by quantitative RT-PCR on RNA derived from archived, paraffin-embedded tissue blocks of an independent validation set comprising 9 HCAs and 9 HCCs.
  • Seven of the 8 genes demonstrated average expression differences between HCA and HCC that were concordant with the microarray findings, and their expression pattern correctly classified the 18 tumors into HCA and HCC using unsupervised clustering analysis.
  • Furthermore, immunohistochemical staining performed on a third, independent set of 27 HCAs and 33 HCCs confirmed the expression differences at protein levels for 5 of the genes.
  • Taken together, our data demonstrate significant molecular differences between HCA and WDHCC, despite their morphologic similarity.
  • More importantly, we have identified a unique set of genes whose expression pattern can discriminate between these two types of hepatocellular neoplasms, suggesting the possibility of future development of ancillary molecular and immunohistochemical diagnostic methods.
  • [MeSH-major] Adenoma, Liver Cell / genetics. Adenoma, Liver Cell / metabolism. Carcinoma, Hepatocellular / genetics. Carcinoma, Hepatocellular / metabolism. Gene Expression Regulation, Neoplastic
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Cluster Analysis. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Male. Middle Aged. Nucleic Acid Hybridization. Oligonucleotide Array Sequence Analysis. RNA / metabolism. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16327432.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 63231-63-0 / RNA
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75. Coselli JS, Bozinovski J, Cheung C: Hypothermic circulatory arrest: safety and efficacy in the operative treatment of descending and thoracoabdominal aortic aneurysms. Ann Thorac Surg; 2008 Mar;85(3):956-63; discussion 964

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypothermic circulatory arrest: safety and efficacy in the operative treatment of descending and thoracoabdominal aortic aneurysms.
  • BACKGROUND: The safety and efficacy of hypothermic circulatory arrest in the operative treatment of descending thoracic aortic aneurysms and thoracoabdominal aortic aneurysms are not clearly established.
  • We evaluated our experience with repair of descending thoracic and thoracoabdominal aortic aneurysms using hypothermic circulatory arrest.
  • METHODS: In all, 111 patients with descending thoracic aortic aneurysms (83) or thoracoabdominal aortic aneurysms (28) underwent graft replacement of the involved aortic segments using hypothermic circulatory arrest.
  • The technique was used when the location, extent, and severity of disease precluded placement of a proximal aortic clamp.
  • Mean circulatory arrest time was 39.7 +/- 16.2 minutes.
  • CONCLUSIONS: When cross clamping the aorta is not feasible, hypothermic circulatory arrest can be performed but with an increased morbidity and mortality rate.
  • [MeSH-major] Aortic Aneurysm, Abdominal / surgery. Aortic Aneurysm, Thoracic / surgery. Circulatory Arrest, Deep Hypothermia Induced

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  • [CommentIn] Ann Thorac Surg. 2008 Oct;86(4):1399-400 [18805214.001]
  • (PMID = 18291178.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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76. Aranki SF, Nathan M, Shekar P, Couper G, Rizzo R, Cohn LH: Hypothermic circulatory arrest enables aortic valve replacement in patients with unclampable aorta. Ann Thorac Surg; 2005 Nov;80(5):1679-86; discussion 1686-7
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  • [Title] Hypothermic circulatory arrest enables aortic valve replacement in patients with unclampable aorta.
  • Different management options include hypothermic circulatory arrest to replace the aortic valve, an aortic endarterectomy, or tube graft replacement of the aorta to allow safe application of cross-clamp before aortic valve replacement.
  • Hypothermic circulatory arrest was used to replace the aortic valve alone, to do an aortic endarterectomy, or replace the ascending aorta with a tube graft.
  • Statistical analysis showed no association between circulatory arrest period and occurrence of adverse cerebral events.
  • CONCLUSIONS: Hypothermic circulatory arrest is an important adjunct that allows aortic valve replacement to be performed with an acceptable mortality but with an increased risk of cerebral event in this high-risk and elderly group of patients.
  • [MeSH-major] Aortic Valve. Heart Arrest. Heart Arrest, Induced / methods. Heart Valve Prosthesis Implantation / methods. Hypothermia, Induced / methods

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  • [CommentIn] Ann Thorac Surg. 2006 Jul;82(1):381 [16798264.001]
  • (PMID = 16242438.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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77. McDonnell MM, McGuigan E, McElhinney J, McTeggart M, McClure D: An analysis of the palliative care education needs of RGNs and HCAs in nursing homes in Ireland. Int J Palliat Nurs; 2009 Sep;15(9):446, 448-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An analysis of the palliative care education needs of RGNs and HCAs in nursing homes in Ireland.
  • AIM: To identify the palliative care education needs of registered general nurses (RGNs) and health-care assistants (HCAs) working in care of the older person units (nursing homes).
  • METHOD: A questionnaire was sent to all RGNs and HCAs working in nursing homes run by the Health Service Executive (HSE) in one health-care region in Ireland.
  • HCAs identified a need to improve their communication skills and clarify their role.
  • There was a significant difference between the RGNs' and the HCAs' level of understanding of palliative care (P = 0.00).
  • CONCLUSION: This study demonstrated that RGNs and HCAs working in care of the older person settings have palliative care educational needs.
  • It also established a difference in the educational background and palliative care understanding of RGNs and HCAs.

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  • (PMID = 19957455.001).
  • [ISSN] 1357-6321
  • [Journal-full-title] International journal of palliative nursing
  • [ISO-abbreviation] Int J Palliat Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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78. Khaladj N, Peterss S, Oetjen P, von Wasielewski R, Hauschild G, Karck M, Haverich A, Hagl C: Hypothermic circulatory arrest with moderate, deep or profound hypothermic selective antegrade cerebral perfusion: which temperature provides best brain protection? Eur J Cardiothorac Surg; 2006 Sep;30(3):492-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypothermic circulatory arrest with moderate, deep or profound hypothermic selective antegrade cerebral perfusion: which temperature provides best brain protection?
  • OBJECTIVE: Selective antegrade cerebral perfusion (SACP) seems to be associated with a better outcome compared to hypothermic circulatory arrest (HCA) alone.
  • METHODS: Twenty-six pigs were included in the study and assigned to 100 min HCA at 20 degrees C body temperature without (n = 6) or with either 10 degrees C (n = 6), 20 degrees C (n = 7) or 30 degrees C (n = 7) of SACP.
  • The 20 degrees C group showed a slight increase of ICP over time, but remained significantly lower compared to HCA (p < 0.05).
  • RT-PCR analysis of brain tissue revealed a reduction for heat shock protein (HSP-72) in 20 degrees C (p < 0.05) and 10 degrees C animals (p = 0.095).
  • Histopathological evaluation showed a reduction of edema and eosinophilic cells in the groups treated with SACP.
  • CONCLUSION: In this model, SACP is superior to HCA alone.
  • [MeSH-major] Brain / physiopathology. Cerebrovascular Circulation / physiology. Heart Arrest, Induced / methods. Hypothermia, Induced / methods
  • [MeSH-minor] Animals. Electroencephalography / methods. Evoked Potentials, Somatosensory / physiology. Female. HSP72 Heat-Shock Proteins / analysis. Hemodynamics / physiology. Intracranial Pressure / physiology. Oxygen / physiology. Perfusion / methods. Polymerase Chain Reaction / methods. Swine. Temperature

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  • [CommentIn] Eur J Cardiothorac Surg. 2007 Jan;31(1):138; author reply 139 [17098440.001]
  • (PMID = 16857368.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / HSP72 Heat-Shock Proteins; S88TT14065 / Oxygen
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79. Peltz M, Douglass DS, Meyer DM, Wait MA, DiMaio JM, Ring WS, Jessen ME: Hypothermic circulatory arrest for repair of injuries of the thoracic aorta and great vessels. Interact Cardiovasc Thorac Surg; 2006 Oct;5(5):560-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypothermic circulatory arrest for repair of injuries of the thoracic aorta and great vessels.
  • Expedient diagnosis and prompt repair by clamping and replacing the affected segment of aorta (often with left-heart bypass) can salvage many patients.
  • Rarely, due to the location of the injury or delayed presentation, standard techniques cannot be used and hypothermic circulatory arrest (HCA) is required for access, exposure and repair.
  • We reviewed all operations on the great vessels at our institution over a 16-year period that had a traumatic etiology and used HCA.
  • All repairs were performed with cardiopulmonary bypass (mean CPB time was 155+/-13 min), deep hypothermia, and an interval of circulatory arrest (mean circulatory arrest interval 31+/-4 min).
  • HCA can be a useful adjunct in managing complex post-traumatic great vessel injuries.
  • Acute injuries of the ascending aorta and transverse arch usually require this technique, but HCA also offers a safe way to manage repair of the descending thoracic aorta when proximal aortic control is compromised.

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  • (PMID = 17670646.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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80. Allen JG, Weiss ES, Wilson MA, Arnaoutakis GJ, Blue ME, Talbot CC Jr, Jie C, Lange MS, Troncoso JC, Johnston MV, Baumgartner WA: Hawley H. Seiler Resident Award. Transcriptional profile of brain injury in hypothermic circulatory arrest and cardiopulmonary bypass. Ann Thorac Surg; 2010 Jun;89(6):1965-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hawley H. Seiler Resident Award. Transcriptional profile of brain injury in hypothermic circulatory arrest and cardiopulmonary bypass.
  • BACKGROUND: Little is known about the molecular mechanisms of neurologic complications after hypothermic circulatory arrest (HCA) with cardiopulmonary bypass (CPB).
  • Canine genome sequencing allows profiling of genomic changes after HCA and CPB alone.
  • METHODS: Dogs underwent 2-hour HCA at 18 degrees C (n = 10), 1-hour HCA (n = 8), or 2-hour CPB at 32 degrees C alone (n = 8).
  • After neurologic scoring, brains were harvested for genomic analysis.
  • RESULTS: Consistent with prior work, dogs that underwent 2-hour HCA experienced severe neurologic injury.
  • One hour of HCA caused intermediate clinical damage.
  • Cardiopulmonary bypass, 1-hour HCA, and 2-hour HCA groups historically demonstrated increasing degrees of histopathologic damage (previously published).
  • Exploratory analysis revealed differences in significantly regulated genes (false discovery rate < 10%, absolute fold change > or = 1.2), with increases in differential gene expression with injury severity.
  • At 8 hours and 24 hours after insult, 2-hour HCA dogs had 502 and 1,057 genes regulated, respectively; 1-hour HCA dogs had 179 and 56 genes regulated; and CPB alone dogs had 5 and 0 genes regulated.
  • CONCLUSIONS: Our genomic profile of canine brains after HCA and CPB revealed 1-hour and 2-hour HCA induced markedly increased gene regulation, in contrast to the minimal effect of CPB alone.

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20494057.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL091541-18; United States / NHLBI NIH HHS / HL / HL091541-18; United States / NIDDK NIH HHS / DK / 2T32DK007713-12; United States / NINDS NIH HHS / NS / R37 NS031238; United States / NINDS NIH HHS / NS / R37NS31238-10; United States / NIDDK NIH HHS / DK / T32 DK007713; United States / NHLBI NIH HHS / HL / R01 HL091541
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS262168; NLM/ PMC3031914
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81. Stier GR, Verde EW: The postoperative care of adult patients exposed to deep hypothermic circulatory arrest. Semin Cardiothorac Vasc Anesth; 2007 Mar;11(1):77-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The postoperative care of adult patients exposed to deep hypothermic circulatory arrest.
  • Deep hypothermic circulatory arrest with cardiopulmonary bypass is indicated for complex surgical operations in adult patients involving the aortic arch, thoracoabdominal aorta, cerebral vasculature, and tumors extending into the vena cava and heart.
  • Neurologic injury is the most troublesome adverse effect after the use of deep hypothermic circulatory arrest and cardiopulmonary bypass, presenting as either a transient neurologic deficit (5.9% to 28.1%) or an irreversible neurologic injury (1.8% to 13.6%).
  • Early postoperative support of organ function, along with timely diagnosis and treatment of organ injury, is essential in minimizing perioperative morbidity, particularly neurologic morbidity.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced. Postoperative Care

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  • (PMID = 17484176.001).
  • [ISSN] 1089-2532
  • [Journal-full-title] Seminars in cardiothoracic and vascular anesthesia
  • [ISO-abbreviation] Semin Cardiothorac Vasc Anesth
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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82. Ziegeler S, Buchinger H, Wilhelm W, Larsen R, Kreuer S: Impact of deep hypothermic circulatory arrest on the BIS index. J Clin Anesth; 2010 Aug;22(5):340-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of deep hypothermic circulatory arrest on the BIS index.
  • STUDY OBJECTIVE: To investigate the influence of duration of deep hypothermic circulatory arrest (DHCA) on recovery of the bispectral index (BIS).
  • Regression analysis between duration of DHCA and BIS10 was R = 0.76; BIS20: R = 0.67; and BIS30: R = 0.54.
  • [MeSH-major] Cardiac Surgical Procedures / methods. Circulatory Arrest, Deep Hypothermia Induced / methods. Consciousness Monitors. Extracorporeal Circulation / methods
  • [MeSH-minor] Aged. Body Temperature. Cohort Studies. Female. Hospitals, University. Humans. Male. Middle Aged. Nasopharynx. Prospective Studies. Regression Analysis. Time Factors

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20650380.001).
  • [ISSN] 1873-4529
  • [Journal-full-title] Journal of clinical anesthesia
  • [ISO-abbreviation] J Clin Anesth
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Gao Y, Zou XM, Wang WJ: [L-arginine pretreatment lowers cerebral metabolism for cerebral protection during deep hypothermic circulatory arrest]. Nan Fang Yi Ke Da Xue Xue Bao; 2008 Jan;28(1):102-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [L-arginine pretreatment lowers cerebral metabolism for cerebral protection during deep hypothermic circulatory arrest].
  • OBJECTIVE: To evaluate the effect of L-arginine pretreatment on cerebral metabolism for cerebral protection during deep hypothermic circulatory arrest (DHCA).
  • [MeSH-major] Arginine / pharmacology. Brain / drug effects. Circulatory Arrest, Deep Hypothermia Induced / methods

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  • (PMID = 18227038.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Indazoles; 2942-42-9 / 7-nitroindazole; 94ZLA3W45F / Arginine
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84. Hickey EJ, You X, Kaimaktchiev V, Stenzel-Poore M, Ungerleider RM: Lipopolysaccharide preconditioning induces robust protection against brain injury resulting from deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg; 2007 Jun;133(6):1588-96

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipopolysaccharide preconditioning induces robust protection against brain injury resulting from deep hypothermic circulatory arrest.
  • Three days later, they experienced 2 hours of deep hypothermic circulatory arrest before being weaned and supported anesthetized for 20 hours in an intensive care setting.
  • Controls included cardiopulmonary bypass without deep hypothermic circulatory arrest (n = 3) and no cardiopulmonary bypass (n = 3).
  • Because lipopolysaccharide preconditioning is a systemic phenomenon offering proven protection against myocardial, hepatic, and pulmonary injury, this technique offers enormous potential for protecting against systemic neonatal injury related to cardiopulmonary bypass.
  • [MeSH-major] Brain Injuries / prevention & control. Circulatory Arrest, Deep Hypothermia Induced. Ischemic Preconditioning / methods. Lipopolysaccharides / pharmacology

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  • (PMID = 17532961.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipopolysaccharides
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85. Wang Y, Chen H, Gong Q, Shen S, Gao Q: Analysis of functional networks involved in motor execution and motor imagery using combined hierarchical clustering analysis and independent component analysis. Magn Reson Imaging; 2010 Jun;28(5):653-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of functional networks involved in motor execution and motor imagery using combined hierarchical clustering analysis and independent component analysis.
  • However, the functional networks of a multitask paradigm which include ME and MI were not widely explored.
  • In this article, we aimed to investigate the functional networks involved in MI and ME using a method combining the hierarchical clustering analysis (HCA) and the independent component analysis (ICA).
  • The findings further demonstrated that the combined HCA with ICA approach was an effective method to analyze the fMRI data of multitasks.
  • [MeSH-minor] Adult. Algorithms. Cluster Analysis. Female. Humans. Male. Principal Component Analysis. Task Performance and Analysis. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20378292.001).
  • [ISSN] 1873-5894
  • [Journal-full-title] Magnetic resonance imaging
  • [ISO-abbreviation] Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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86. Amir G, Ramamoorthy C, Riemer RK, Hanley FL, Reddy VM: Deep brain hyperthermia while rewarming from hypothermic circulatory arrest. J Card Surg; 2009 Sep-Oct;24(5):606-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep brain hyperthermia while rewarming from hypothermic circulatory arrest.
  • BACKGROUND: Neurologic injury is a feared and serious long-term complication of cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA).
  • METHODS: Neonatal piglets (n = 9) were subject to CPB and cooled to rectal temperature (RT) of 18 degrees C, 30 minutes of DHCA were initiated, and subsequently the piglets were rewarmed to RT of 36.5 degrees C and weaned from CPB.
  • RT, nasopharyngeal (NPT), and tympanic (TT) temperatures were recorded.
  • RESULTS: During cooling the deep brain cooled faster and to lower temperatures compared to RT and TT; NPT reflected DBT accurately.
  • During rewarming DBT was significantly higher than RT and TT.
  • By the end of rewarming the difference between the deep brain and the RT reached statistical significance (30 minutes: 35.1 +/- 0.7 vs. 32.3 +/- 0.7 p < 0.05, respectively, 40 minutes: 37.5 +/- 0.3 vs. 34.7 +/- 0.8 p < 0.05, respectively).
  • [MeSH-major] Brain Diseases / etiology. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Fever / etiology
  • [MeSH-minor] Analysis of Variance. Animals. Body Temperature. Cardiopulmonary Bypass. Oxygen Consumption. Rectum. Risk Factors. Swine. Tympanic Membrane

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  • (PMID = 19740304.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Barreiro CJ, Williams JA, Fitton TP, Lange MS, Blue ME, Kratz L, Barker PB, Degaonkar M, Gott VL, Troncoso JC, Johnston MV, Baumgartner WA: Noninvasive assessment of brain injury in a canine model of hypothermic circulatory arrest using magnetic resonance spectroscopy. Ann Thorac Surg; 2006 May;81(5):1593-8
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  • [Title] Noninvasive assessment of brain injury in a canine model of hypothermic circulatory arrest using magnetic resonance spectroscopy.
  • BACKGROUND: Studies have confirmed the neuroprotective effect of diazoxide in canines undergoing hypothermic circulatory arrest (HCA).
  • We demonstrated that noninvasive measurement of NAA:Cho with magnetic resonance spectroscopy facilitates assessment of neuronal injury after HCA and allows for evaluation of neuroprotective strategies.
  • METHODS: Canines underwent 2 hours of HCA at 18 degrees C and were observed for 24 hours.
  • Animals were divided into three groups (n = 15 in each group): normal (unoperated), HCA (HCA only), and HCA+diazoxide (pharmacologic treatment before HCA).
  • The NAA:Cho ratios were obtained 24 hours after HCA by spectroscopy.
  • Separate cohorts of HCA (n = 16) and HCA+diazoxide (n = 23) animals were kept alive for 72 hours for daily neurologic assessment.
  • RESULTS: Cortical NAA:Cho ratios were significantly decreased in HCA versus normal animals (1.01 +/- 0.29 versus 1.31 +/- 0.23; p = 0.004), consistent with severe neurologic injury.
  • Diazoxide pretreatment limited neurologic injury versus HCA alone, reflected in a preserved NAA:Cho ratio (1.21 +/- 0.27 versus 1.01 +/- 0.29; p = 0.05).
  • A significant decrease in cortical NAA was observed in HCA versus normal (7.07 +/- 1.9 versus 8.54 +/- 2.1 micromol/g; p = 0.05), with maintenance of normal NAA levels after diazoxide pretreatment (9.49 +/- 1.1 versus 7.07 +/- 1.9 micromol/g; p = 0.0002).
  • Clinical neurologic scores were significantly improved in the HCA+diazoxide group versus HCA at all time points.
  • CONCLUSIONS: Neurologic injury remains a significant complication of cardiac surgery and is most severe after HCA.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced. Hypoxia, Brain / diagnosis. Magnetic Resonance Spectroscopy

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  • (PMID = 16631640.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / R37NS31238-10
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Vasodilator Agents; 30KYC7MIAI / Aspartic Acid; 997-55-7 / N-acetylaspartate; N91BDP6H0X / Choline; O5CB12L4FN / Diazoxide
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88. Amir G, Ramamoorthy C, Riemer RK, Reddy VM, Hanley FL: Neonatal brain protection and deep hypothermic circulatory arrest: pathophysiology of ischemic neuronal injury and protective strategies. Ann Thorac Surg; 2005 Nov;80(5):1955-64
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  • [Title] Neonatal brain protection and deep hypothermic circulatory arrest: pathophysiology of ischemic neuronal injury and protective strategies.
  • Deep hypothermic circulatory arrest (DHCA) has been used for the past 50 years in the surgical repair of complex congenital cardiac malformations and operations involving the aortic arch; it enables the surgeon to achieve precise anatomical reconstructions by creating a bloodless operative field.
  • Surgical techniques consist of intermittent cerebral perfusion during periods of circulatory arrest and continuous regional brain perfusion.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Hypoxia, Brain / physiopathology
  • [MeSH-minor] Adult. Animals. Cell Death. Heart Defects, Congenital / surgery. Humans. Infant. Infant, Newborn

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  • (PMID = 16242503.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 79
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89. Romano M: All's fair in healthcare? Heartland Spine & Specialty Hospital alleges HCA Midwest Division conspired with local payers to drive it out of business. Mod Healthc; 2005 May 9;35(19):6-7, 10, 1
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  • [Title] All's fair in healthcare? Heartland Spine & Specialty Hospital alleges HCA Midwest Division conspired with local payers to drive it out of business.
  • A Kansas specialty hospital is accusing HCA of pressuring managed-care companies to exclude rivals from networks and is suing the chain.

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  • (PMID = 15929243.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] Journal Article; Legal Cases
  • [Publication-country] United States
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90. Elbers PW, Ozdemir A, Heijmen RH, Heeren J, van Iterson M, van Dongen EP, Ince C: Microvascular hemodynamics in human hypothermic circulatory arrest and selective antegrade cerebral perfusion. Crit Care Med; 2010 Jul;38(7):1548-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microvascular hemodynamics in human hypothermic circulatory arrest and selective antegrade cerebral perfusion.
  • OBJECTIVE: The behavior of the human microcirculation in the setting of cardiac arrest is largely unknown.
  • In addition, the time it takes for capillary blood flow to stop after the heart arrests is debated.
  • Aortic arch surgery frequently necessitates deep hypothermic circulatory arrest and subsequent selective antegrade cerebral perfusion.
  • SETTING: Operating room of a large tertiary referral center for cardiac surgery.
  • INTERVENTIONS: We used sidestream dark field imaging to study the sublingual microcirculation immediately before circulatory arrest, during circulatory arrest, and immediately after selective antegrade cerebral perfusion.
  • Before circulatory arrest, perfused vessel density was 6.41 (1.18) for small (<20 microm) and 1.57 (0.88) mm for large (>20 microm) microvessels.
  • After circulatory arrest, there was no equilibration of arterial and venous blood pressure before onset of selective antegrade cerebral perfusion after 59 (17) secs (range, 40-80 secs).
  • Flow in small microvessels came to a complete stop after 45 (9) secs (range, 34-57 secs) after transition to circulatory arrest.
  • Selective antegrade cerebral perfusion restored microvascular flow, reaching precirculatory arrest levels after 45 (27) secs (range, 20-85 secs).
  • CONCLUSIONS: In a controlled surgical setting, circulatory arrest in humans induces a complete sublingual small microvessel shutdown within 1 min.
  • Selective antegrade cerebral perfusion was able to restore microvascular flow to precirculatory arrest levels within a similar timeframe.
  • [MeSH-major] Aorta, Thoracic / surgery. Cerebral Arteries / physiopathology. Cerebrovascular Circulation. Circulatory Arrest, Deep Hypothermia Induced. Microvessels / physiopathology. Mouth Floor / blood supply

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  • (PMID = 20473147.001).
  • [ISSN] 1530-0293
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Cui XN, Tang JW, Song B, Wang B, Chen SY, Hou L: High expression of osteoglycin decreases gelatinase activity of murine hepatocarcinoma Hca-F cells. World J Gastroenterol; 2009 Dec 28;15(48):6117-22
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  • [Title] High expression of osteoglycin decreases gelatinase activity of murine hepatocarcinoma Hca-F cells.
  • AIM: To investigate the possible correlation between osteoglycin expression and gelatinase activity of mouse hepatocarcinoma Hca-F cells.
  • METHODS: A eukaryotic expression plasmid pIRESpuro3 osteoglycin(+) was constructed and transfected into Hca-F cells to investigate the possible correlation between osteoglycin expression and gelatinase activity of Hca-F cells cultured with extract of lymph node, liver, spleen or in DMEM medium.
  • The activity of gelatinases was examined through zymographic analysis.
  • RESULTS: High expression of osteoglycin attenuated the gelatinase activity of Hca-F cells cultured with extract of lymph node, and at the same time, decreased the metastatic potential of Hca-F cells to peripheral lymph nodes in vivo.
  • CONCLUSION: High expression of osteoglycin decreases the gelatinase activity of Hca-F cells cultured with extract of lymph node; regulation of gelatinase activity might be one of mechanisms that osteoglycin contributes to lymphatic metastasis suppression.
  • [MeSH-major] Carcinoma, Hepatocellular / enzymology. Gelatinases / metabolism. Intercellular Signaling Peptides and Proteins / metabolism. Liver Neoplasms / enzymology
  • [MeSH-minor] Animals. Cell Line, Tumor. Lymphatic Metastasis. Male. Mice. Mice, Inbred Strains. RNA, Messenger / metabolism. Transfection

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  • (PMID = 20027687.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / Ogn protein, mouse; 0 / RNA, Messenger; EC 3.4.24.- / Gelatinases
  • [Other-IDs] NLM/ PMC2797671
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92. Mahan VL, Ilangovan S, Cuison R, Patil J, Dockter S, Rizzo V, Ilbawi M: Does antegrade cerebral perfusion protect the brain during deep hypothermic circulatory arrest? J Pediatr Surg; 2005 Mar;40(3):510-5
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  • [Title] Does antegrade cerebral perfusion protect the brain during deep hypothermic circulatory arrest?
  • PURPOSE: This study compares cerebral protection using no cerebroplegia and using antegrade cerebroplegia with variable flow rates during deep hypothermic circulatory arrest (DHCA).
  • [MeSH-major] Brain Damage, Chronic / prevention & control. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Electrolytes / therapeutic use. Hypoxia-Ischemia, Brain / prevention & control. Perfusion / methods. Postoperative Complications / prevention & control. Reperfusion Injury / prevention & control

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  • (PMID = 15793727.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Electrolytes; 0 / Lactates; 0 / Nerve Growth Factors; 0 / Pyruvates; 0 / S100 Calcium Binding Protein beta Subunit; 0 / S100 Proteins; 97397-05-2 / Plasmalyte A; EC 2.7.3.2 / Creatine Kinase, BB Form; IHS69L0Y4T / Cefazolin; X4W7ZR7023 / Methylprednisolone
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93. Caffarelli AD, Holden JP, Baron EJ, Lemmens HJ, D'Souza H, Yau V, Olcott C 4th, Reitz BA, Miller DC, van der Starre PJ: Plasma cefazolin levels during cardiovascular surgery: effects of cardiopulmonary bypass and profound hypothermic circulatory arrest. J Thorac Cardiovasc Surg; 2006 Jun;131(6):1338-43
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  • [Title] Plasma cefazolin levels during cardiovascular surgery: effects of cardiopulmonary bypass and profound hypothermic circulatory arrest.
  • OBJECTIVES: We sought to assess the effects of cardiopulmonary bypass and profound hypothermic circulatory arrest on plasma cefazolin levels administered for antimicrobial prophylaxis in cardiovascular surgery.
  • METHODS: Four groups (10 patients per group) were prospectively studied: vascular surgery without cardiopulmonary bypass (group A), cardiac surgery with a cardiopulmonary bypass time of less than 120 minutes (group B), cardiac surgery with a cardiopulmonary bypass time of greater than 120 minutes (group C), and cardiac surgery with cardiopulmonary bypass and profound hypothermic circulatory arrest (group D).
  • Cefazolin plasma concentrations were determined by using a radial diffusion assay, with Staphylococcus aureus as the indicator microorganism.
  • Patients undergoing profound hypothermic circulatory arrest are better protected, but the described protocol of prophylaxis is not optimal.
  • [MeSH-major] Anti-Bacterial Agents / blood. Antibiotic Prophylaxis. Cardiopulmonary Bypass. Cefazolin / blood. Circulatory Arrest, Deep Hypothermia Induced

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  • (PMID = 16733167.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; IHS69L0Y4T / Cefazolin
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94. Orido T, Fujino H, Hasegawa Y, Toyomura K, Kawashima T, Murayama T: Indomethacin decreases arachidonic acid uptake in HCA-7 human colon cancer cells. J Pharmacol Sci; 2008 Nov;108(3):389-92
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  • [Title] Indomethacin decreases arachidonic acid uptake in HCA-7 human colon cancer cells.
  • We now show that indomethacin, a popular NSAID, significantly reduced the [3H]-arachidonic acid uptake in HCA-7 human colon cancer cells.
  • Interestingly, no decrease in the uptake of [3H]-arachidonic acid occurred when the cells were treated with aspirin, diclofenac, and sulindac even though the concentrations of these NSAIDs were high enough to inhibit COX-2 activity.
  • [MeSH-minor] Cell Line, Tumor. Humans

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  • (PMID = 18987430.001).
  • [ISSN] 1347-8613
  • [Journal-full-title] Journal of pharmacological sciences
  • [ISO-abbreviation] J. Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Antineoplastic Agents; 27YG812J1I / Arachidonic Acid; XXE1CET956 / Indomethacin
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95. Reddy SK, Kishnani PS, Sullivan JA, Koeberl DD, Desai DM, Skinner MA, Rice HE, Clary BM: Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia. J Hepatol; 2007 Nov;47(5):658-63
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  • [Title] Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia.
  • BACKGROUND/AIMS: Because dietary modifications have prolonged the life expectancy of patients with glycogen storage disease type Ia (GSD Ia), the incidence of hepatocellular adenoma (HCA) to carcinoma (HCC) transformation is increasing.
  • The objective of this retrospective study is to assess the safety and effectiveness of HCA resection in GSD Ia patients.
  • METHODS: Clinicopathologic, peri-operative, and long-term data were reviewed from patients who underwent HCA resection.
  • Comparisons were made with Fisher's exact, Mann-Whitney U, and log-rank tests; survival was estimated with Kaplan-Meier analysis.
  • RESULTS: From 1998 to 2006, 38 patients underwent HCA resection.
  • GSD Ia patients had greater morbidity (86% vs. 20%) and shorter time to adenoma progression (median 23 months vs. not yet reached) after partial hepatectomy compared to the general population (p<0.05).
  • Three GSD Ia patients underwent liver transplantation 77, 32, and 23 months after adenoma resection.
  • CONCLUSIONS: Despite substantial morbidity, partial hepatectomy is feasible in GSD Ia patients and is an effective intermediate step in the prevention of HCC until definitive treatment with liver transplantation.
  • [MeSH-major] Adenoma, Liver Cell / surgery. Biliary Tract Surgical Procedures / statistics & numerical data. Glycogen Storage Disease Type I / complications. Liver / surgery. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Comorbidity. Disease Progression. Female. Humans. Liver Transplantation / statistics & numerical data. Male. Middle Aged. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17637480.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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96. Shum-Tim D, MacDonald D, Takayuki S, Laliberté E, Chen J, Jamal AM, Philip A, Platt R: Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest. Pediatr Crit Care Med; 2005 May;6(3):319-26
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  • [Title] Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest.
  • OBJECTIVE: The objective of this study was to evaluate the systemic and cerebral effects of different postoperative hematocrit management following cardiopulmonary bypass and deep hypothermic circulatory arrest.
  • INTERVENTIONS: Twelve piglets were subjected to cardiopulmonary bypass (hematocrit = 25%) and 100 mins of deep hypothermic circulatory arrest (15 degrees C).
  • Near-infrared spectroscopy and immunohistochemical assays for cerebral transforming growth factor-beta(1) and caspase-3 were performed.
  • CONCLUSIONS: Lower postoperative hematocrit was associated with increased fluid retention, lower perfusion pressure, and worse cerebrovascular injury following deep hypothermic circulatory arrest.
  • Postoperative hematocrit management may have profound systemic and cerebral effects after deep hypothermic circulatory arrest and merits further investigation.

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  • (PMID = 15857532.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins; 0 / Oxyhemoglobins; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1; 9008-02-0 / deoxyhemoglobin; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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97. Kerendi F, Halkos ME, Kin H, Corvera JS, Brat DJ, Wagner MB, Vinten-Johansen J, Zhao ZQ, Forbess JM, Kanter KR, Kelley ME, Kirshbom PM: Upregulation of hypoxia inducible factor is associated with attenuation of neuronal injury in neonatal piglets undergoing deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg; 2005 Oct;130(4):1079
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  • [Title] Upregulation of hypoxia inducible factor is associated with attenuation of neuronal injury in neonatal piglets undergoing deep hypothermic circulatory arrest.
  • BACKGROUND: Prolonged deep hypothermic circulatory arrest is known to cause neurological injury.
  • This study tested the hypothesis that upregulation of hypoxia inducible factor and erythropoietin by preconditioning with hypoxia or the hypoxia-mimetic agents deferoxamine and cobalt chloride would be neuroprotective in a piglet model of deep hypothermic circulatory arrest.
  • Twenty-four hours after treatment, 6 to 7 animals per group underwent cardiopulmonary bypass and 110 minutes of deep hypothermic circulatory arrest.
  • Finally, cleaved caspase 3 (a marker of apoptotic cell death) was also shown to be diminished in the cobalt and deferoxamine groups, but the difference was not significantly different from the value in the control group.
  • CONCLUSIONS: In contrast to hypoxia, deferoxamine and cobalt chloride preconditioning upregulated hypoxia inducible factor and were associated with histopathologic neuroprotection after exposure to cardiopulmonary bypass and prolonged deep hypothermic circulatory arrest.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Erythropoietin / physiology. Hypoxia-Inducible Factor 1 / physiology. Postoperative Complications / prevention & control. Up-Regulation

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  • (PMID = 16214523.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypoxia-Inducible Factor 1; 11096-26-7 / Erythropoietin
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98. Zou P, Hong Y, Koh HL: Chemical fingerprinting of Isatis indigotica root by RP-HPLC and hierarchical clustering analysis. J Pharm Biomed Anal; 2005 Jul 1;38(3):514-20
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  • [Title] Chemical fingerprinting of Isatis indigotica root by RP-HPLC and hierarchical clustering analysis.
  • Hierarchical clustering analysis gave similar results as the visual comparison.
  • This is the first report of hierarchical clustering analysis of I. indigotica root.
  • [MeSH-major] Chromatography, High Pressure Liquid / methods. Cluster Analysis. Isatis / chemistry. Plant Extracts / analysis. Plant Roots / chemistry
  • [MeSH-minor] Drugs, Chinese Herbal / analysis. Drugs, Chinese Herbal / chemistry. Indigo Carmine. Indoles / analysis. Molecular Structure. Powders. Reference Standards. Reproducibility of Results. Technology, Pharmaceutical / methods

  • Hazardous Substances Data Bank. INDIGO .
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  • (PMID = 15925253.001).
  • [ISSN] 0731-7085
  • [Journal-full-title] Journal of pharmaceutical and biomedical analysis
  • [ISO-abbreviation] J Pharm Biomed Anal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Indoles; 0 / Plant Extracts; 0 / Powders; D3741U8K7L / Indigo Carmine; V86L8P74GI / indirubin
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99. Hagl C, Weisz DJ, Khaladj N, Griepp MM, Spielvogel D, Yang BY, de Asla RA, Bodian CA, Griepp RB: Use of a maze to detect cognitive dysfunction in a porcine model of hypothermic circulatory arrest. Ann Thorac Surg; 2005 Apr;79(4):1307-14; discussion 1314-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of a maze to detect cognitive dysfunction in a porcine model of hypothermic circulatory arrest.
  • BACKGROUND: Hypothermic circulatory arrest (HCA) can result in cognitive impairment not reflected by histopathology or gross neurologic observation.
  • We tested the sensitivity of two multi-room maze tasks in detecting cerebral dysfunction after HCA in pigs.
  • 13 underwent 90 minutes HCA at 20 degrees C and were trained from postoperative day (POD) 7; 14 were unoperated controls.
  • Task 1 did not distinguish between control and HCA groups (p = 0.5), but task 2 revealed significantly (p = 0.04) better learning in controls.
  • CONCLUSIONS: The significantly poorer performance of pigs after HCA suggests that the reversal of baited rooms in task 2 provides the sensitivity to detect cognitive dysfunction.
  • The maze is a promising tool to investigate in pigs the mild cerebral damage often seen after HCA.
  • [MeSH-major] Cognition Disorders / diagnosis. Heart Arrest, Induced / adverse effects. Maze Learning
  • [MeSH-minor] Animals. Cardiopulmonary Bypass. Disease Models, Animal. Swine

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  • (PMID = 15797068.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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100. van der Starre PJ, Kolz M, Lemmens HJ, Faix JD, Mitchell S, Miller C: Vancomycin plasma concentrations in cardiac surgery with the use of profound hypothermic circulatory arrest. Eur J Cardiothorac Surg; 2010 Dec;38(6):741-4
Hazardous Substances Data Bank. Vancomycin .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vancomycin plasma concentrations in cardiac surgery with the use of profound hypothermic circulatory arrest.
  • OBJECTIVE: This study was undertaken to compare the effect of deep hypothermic circulatory arrest, compared with moderate hypothermia, on the plasma concentrations and pharmacokinetic profile of vancomycin, administered as prophylaxis, in patients undergoing cardiac surgery with cardiopulmonary bypass.
  • One group consisted of 12 patients undergoing valvular surgery with moderate hypothermia, and another group was of 12 patients undergoing surgery with the use of profound hypothermic circulatory arrest.
  • CONCLUSION: The dosing of vancomycin, if used as antibiotic prophylaxis, does not need to be adjusted in cardiac surgery patients when undergoing profound hypothermic circulatory arrest, since the plasma concentrations and pharmacokinetic profile are similar to patients with moderate hypothermia.
  • [MeSH-major] Anti-Bacterial Agents / blood. Antibiotic Prophylaxis / methods. Cardiac Surgical Procedures / methods. Circulatory Arrest, Deep Hypothermia Induced. Vancomycin / blood

  • MedlinePlus Health Information. consumer health - Antibiotics.
  • MedlinePlus Health Information. consumer health - Heart Surgery.
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  • [Copyright] Copyright © 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20663677.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 6Q205EH1VU / Vancomycin
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