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6. Delmo Walter EM, Hübler M, Alexi-Meskishvili V, Miera O, Weng Y, Loforte A, Berger F, Hetzer R: Staged surgical palliation in hypoplastic left heart syndrome and its variants. J Card Surg; 2009 Jul-Aug;24(4):383-91
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  • [Title] Staged surgical palliation in hypoplastic left heart syndrome and its variants.
  • BACKGROUND: Surgical options for infants with hypoplastic left heart syndrome (HLHS) and/or its variants are cardiac transplantation or the heart-preserving staged palliation with Norwood operation,followed by a two-staged Fontan procedure.
  • The causes of mortality were sepsis, capillary leak,or heart failure.
  • One patient underwent heart transplantation after the second stage because of heart failure.
  • Among 34 Norwood survivors, four are slightly tachypneic from a mild pulmonary hyperperfusion; one presents symptoms of minimal brain disease.
  • Lower operative weight, ascending aortic size, prolonged duration of cardiopulmonary bypass, and hypothermic circulatory arrest were identified to significantly influence early mortality after the Norwood procedure.
  • [MeSH-major] Cardiovascular Surgical Procedures / methods. Hypoplastic Left Heart Syndrome / mortality. Hypoplastic Left Heart Syndrome / surgery. Outcome Assessment (Health Care). Palliative Care
  • [MeSH-minor] Abnormalities, Multiple. Aorta / pathology. Arrhythmias, Cardiac / mortality. Body Weight. Cardiopulmonary Bypass / statistics & numerical data. Circulatory Arrest, Deep Hypothermia Induced. Female. Follow-Up Studies. Heart Failure / mortality. Humans. Infant. Infant, Newborn. Male. Multivariate Analysis. Retrospective Studies. Risk Factors. Sepsis / mortality. Time Factors

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  • (PMID = 19040407.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Wang D, Lagerstrom R, Sun C, Bishof L, Valotton P, Götte M: HCA-vision: Automated neurite outgrowth analysis. J Biomol Screen; 2010 Oct;15(9):1165-70
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  • [Title] HCA-vision: Automated neurite outgrowth analysis.
  • Automating the analysis of neurons in culture represents a key aspect of the search for neuroactive compounds.
  • A number of commercial neurite analysis software packages tend to measure some basic features such as total neurite length and number of branching points.
  • The authors have developed a suite of image analysis tools that will allow researchers to produce quality analyses at primary screening rates.
  • In mixed cell populations, neurons can be filtered and separated from other brain cell types so that neurite analysis can be performed only on neurons.
  • It supports batch processing with a built-in database to store the batch-processing results, a batch result viewer, and an ad hoc query builder for users to retrieve features of interest.
  • The suite of tools has been deployed into a software package called HCA-Vision.
  • The free version of the software package is available at http://www.hca-vision.com.

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  • (PMID = 20855562.001).
  • [ISSN] 1552-454X
  • [Journal-full-title] Journal of biomolecular screening
  • [ISO-abbreviation] J Biomol Screen
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor
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8. Holst RM, Laurini R, Jacobsson B, Samuelsson E, Sävman K, Doverhag C, Wennerholm UB, Hagberg H: Expression of cytokines and chemokines in cervical and amniotic fluid: relationship to histological chorioamnionitis. J Matern Fetal Neonatal Med; 2007 Dec;20(12):885-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To correlate cervical and amniotic fluid cytokines and macrophage-related chemokines to the development of histological chorioamnionitis (HCA) in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PPROM).
  • STUDY DESIGN: Cervical and amniotic fluid interleukin (IL)-6, IL-8, IL-18, monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 from pregnant women (at <or=34 weeks of gestation) in PTL (N = 42) were analyzed and related to the subsequent occurrence of HCA or inflammatory signs in the placenta.
  • RESULTS: Intra-amniotic levels of IL-6, IL-8, IL-18, MCP-1, and MCP-3 were significantly higher in PTL cases with HCA compared to non-HCA controls, whereas no such relationship was obtained in the PPROM group.
  • Cervical IL-8 and IL-6 (but not IL-18, MCP-1, MCP-2, and MCP-3) in PTL patients was associated with HCA, and at a cut-off level of 10.0 ng/mL cervical IL-8 was a strong predictor of HCA in the PTL cases (sensitivity 100%, specificity 67%, positive predictive value 63%, negative predictive value 100%).
  • The cytokine and chemokine levels in the group with inflammatory signs were generally higher than in controls but lower compared to the concentrations in the HCA group.
  • CONCLUSIONS: The amniotic levels of IL-6, IL-8, IL-18, and the CC-chemokines MCP-1 and MCP-3 in PTL patients all predicted HCA, whereas only IL-8 was a clinically useful marker of HCA in the cervical fluid.

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  • (PMID = 18050018.001).
  • [ISSN] 1476-7058
  • [Journal-full-title] The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • [ISO-abbreviation] J. Matern. Fetal. Neonatal. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Chemokine CCL2; 0 / Chemokines; 0 / Cytokines; 0 / Interleukins
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9. Hancock H, Campbell S, Ramprogus V, Kilgour J: Role development in health care assistants: the impact of education on practice. J Eval Clin Pract; 2005 Oct;11(5):489-98
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  • In nursing this has resulted in the delegation of 'nursing care' to health care assistants (HCAs).
  • This study sought to evaluate the impact of a HCA Development Programme on care delivery.
  • Secondly, it sought to understand the preparedness of HCAs to undertake the programme and the new roles set for them.
  • Semi-structured interviews were conducted with four HCAs, eight of each of their colleagues and four patients.
  • For part two, 12 HCAs were interviewed.
  • Data were analysed following the principles of thematic analysis.
  • FINDINGS: The findings for part one showed positive changes to the HCAs' role, which included skill and knowledge development, increased confidence and initiative and a more holistic approach to care.
  • The HCAs in part two voiced positive and negative views of their role development.
  • Of the 12 HCAs interviewed, eight were prepared to attend the programme, two were undecided, and two were reluctant to attend.
  • CONCLUSIONS: The findings indicated that while the HCA Development Programme positively influenced the role of the HCA, there was a need to invest more into preparation for the restructuring of roles.

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  • (PMID = 16164591.001).
  • [ISSN] 1356-1294
  • [Journal-full-title] Journal of evaluation in clinical practice
  • [ISO-abbreviation] J Eval Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Hu JX, Miao XY, Zhong DW, Dai WD, Liu W: Anterior approach for complete isolated caudate lobectomy. Hepatogastroenterology; 2005 Nov-Dec;52(66):1641-4
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  • BACKGROUND/AIMS: Complete isolated caudate lobectomy is a technique-demanding procedure that entails the surgeon's judgement and precise knowledge of liver anatomy.
  • En bloc excisions combined with adjacent hepatic parenchyma (as part of extended hepatectomies) or wedge excisions of the caudate lobe were excluded.
  • Primary diagnoses included hepatocellular carcinoma, hemangioma and adenoma.
  • Intraoperative US showed no tumor embolus within the main hepatic veins.
  • CONCLUSIONS: Complete isolated resection of the caudate lobe using the anterior approach should be the first choice for treatment of a tumor located in the caudate lobe alone, although the procedure is extremely difficult and highly dangerous.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Hemostasis, Surgical / methods. Hepatectomy / methods. Liver Neoplasms / surgery. Neoplasm Invasiveness / pathology

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  • (PMID = 16334747.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
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11. Henriksen U, Fog J, Loechel F, Praestegaard M: Profiling of multiple signal pathway activities by multiplexing antibody and GFP-based translocation assays. Comb Chem High Throughput Screen; 2008 Aug;11(7):537-44
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  • [Title] Profiling of multiple signal pathway activities by multiplexing antibody and GFP-based translocation assays.
  • Multiplexing of GFP based and immunofluorescence translocation assays enables easy acquisition of multiple readouts from the same cell in a single assay run.
  • Immunofluorescence assays monitor translocation, phosphorylation, and up/down regulation of endogenous proteins.
  • GFP-based assays monitor translocation of stably expressed GFP-fusion proteins.
  • Such assays may be multiplexed along (vertical), across (horizontal), and between (branch) signal pathways.
  • 1) The MK2-GFP assay monitors translocation of MK2-GFP from the nucleus to the cytoplasm in response to stimulation of the p38 pathway.
  • By applying different immunofluorescent assays to the MK2 assay, a multiplexed HCA system is created for deconvolution of p38 pathway activation including assay readouts for MK2, p38, NFkappaB, and c-Jun.
  • 2) A method for evaluating GPCR activation and internalization in a single assay run has been established by multiplexing GFP-based internalization assays with immunofluorescence assays for downstream transducers of GPCR activity: pCREB (cAMP sensor), NFATc1 (Ca(2+) sensor), and ERK (G-protein activation).
  • 3) Cell toxicity readouts can be linked to primary readouts of interest via acquisition of secondary parameters describing cellular morphology.
  • The ATF6 Redistribution assay is provided as an example.
  • These multiplex strategies provide a unique opportunity to enhance HCA data quality and save time during drug discovery.
  • From a single assay run, several assay readouts are obtained that help the user to deconvolute the mode of action of test compounds.
  • [MeSH-major] Antibodies / analysis. Green Fluorescent Proteins / analysis. Signal Transduction

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  • (PMID = 18694390.001).
  • [ISSN] 1386-2073
  • [Journal-full-title] Combinatorial chemistry & high throughput screening
  • [ISO-abbreviation] Comb. Chem. High Throughput Screen.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.- / Phosphotransferases
  • [Number-of-references] 23
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12. Terkivatan T, Hussain SM, De Man RA, Ijzermans JN: Diagnosis and treatment of benign focal liver lesions. Scand J Gastroenterol Suppl; 2006;(243):102-15
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  • [Title] Diagnosis and treatment of benign focal liver lesions.
  • BACKGROUND: With the routine use of improved imaging modalities, more benign liver lesions are detected nowadays.
  • METHODS: A Medline search of studies relevant to imaging diagnosis and management of the most common, benign, solid and non-solid liver lesions was undertaken.
  • The authors' own experiences with benign liver lesions were also taken into account.
  • RESULTS: Although atypical imaging features are the exception rather than the rule, it is sometimes difficult to differentiate between benign and malignant lesions, and knowledge of their imaging features is essential if unnecessary work-up is to be avoided.
  • The use of tissue-specific contrast media, which has clearly improved the accuracy of highly advanced radiological techniques, may be helpful during differential diagnosis.
  • Once having established an accurate diagnosis, surgery is rarely indicated for a benign liver lesion because of its asymptomatic nature.
  • [MeSH-major] Focal Nodular Hyperplasia / diagnosis. Focal Nodular Hyperplasia / therapy. Liver Neoplasms / diagnosis. Liver Neoplasms / therapy
  • [MeSH-minor] Adenoma, Liver Cell / diagnosis. Adenoma, Liver Cell / therapy. Angiomyolipoma / diagnosis. Angiomyolipoma / therapy. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / therapy. Echinococcosis, Hepatic / diagnosis. Echinococcosis, Hepatic / therapy. Embolization, Therapeutic. Hamartoma / diagnosis. Hamartoma / therapy. Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / therapy. Hepatectomy. Humans

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  • (PMID = 16782629.001).
  • [ISSN] 0085-5928
  • [Journal-full-title] Scandinavian journal of gastroenterology. Supplement
  • [ISO-abbreviation] Scand. J. Gastroenterol. Suppl.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 144
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13. Talati H, Radhi J, Popovich S, Marcaccio M: Hepatic Epithelioid Angiomyolipoma: Case Series. Gastroenterology Res; 2010 Dec;3(6):293-295
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  • [Title] Hepatic Epithelioid Angiomyolipoma: Case Series.
  • : Hepatic epithelioid angiomyolipoma (AML) is a rare, benign, mesenchymal neoplasm found in both males and females, and most commonly encountered in adult females.
  • Histomorphologically, they resemble hepatocellular carcinoma.
  • The tumor cells are strongly positive for homatropine methylbromide-45 (HMB-45) and smooth muscle actin by immunohistochemistry, which are the key markers for accurate pathological diagnosis.
  • Hepatic AML should be considered in the differential diagnosis of a well circumscribed hepatic mass, even in the absence of an adipose tissue component.

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  • (PMID = 27942312.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Adenoma / Epithelioid angiomyolipoma / Hepatocellular carcinoma / Liver
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4. Lee KH, Lee BM: Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia. J Toxicol Environ Health A; 2007 Mar 1;70(5):388-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia.
  • (-)-Hydroxycitric acid (HCA) is widely used as an ingredient for nutritional supplements aimed at reducing food intake, appetite, and body weight.
  • In this study, the genotoxicity of HCA was evaluated using three tests: a bacterial reverse mutation assay (Ames test), an in vitro chromosomal aberration (CA) test, and an in vivo micronucleus (MN) test.
  • HCA was negative by the Ames test in the presence or absence of a microsomal metabolizing system.
  • HCA did not induce mutagenic activity in the Ames test, and no significant mutagenic potency was indicated by CA tests.
  • However, HCA significantly and dose-dependently increased the number of MNPCEs (micronucleated polychromatic erythrocytes/1000 polychromatic erythrocytes) and PCE/(PCE + NCE) ratios according to the MN test.
  • These results suggest that HCA preferentially induce micronuclei.
  • [MeSH-minor] Animals. Cell Line. Chromosome Aberrations / chemically induced. Cricetinae. Cricetulus. Garcinia cambogia. Mice. Mutagenicity Tests

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  • [CommentIn] J Toxicol Environ Health A. 2008;71(5):348-9; author reply 350-1 [18214809.001]
  • (PMID = 17454564.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Citrates; 8W94T9026R / hydroxycitric acid
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15. Basaran C, Karcaaltincaba M, Akata D, Karabulut N, Akinci D, Ozmen M, Akhan O: Fat-containing lesions of the liver: cross-sectional imaging findings with emphasis on MRI. AJR Am J Roentgenol; 2005 Apr;184(4):1103-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fat-containing lesions of the liver: cross-sectional imaging findings with emphasis on MRI.
  • OBJECTIVE: The purpose of this pictorial essay is to identify different types of liver lesions that contain fat.
  • Cross-sectional imaging findings of fat- or lipid-containing lesions can help in characterizing focal liver lesions.
  • We searched our archive retrospectively and reviewed the literature for fat-containing liver lesions and identified 16 different types.
  • CONCLUSION: These lesions can contain macroscopic fat (i.e., angiomyolipoma, lipoma, liposarcoma, hydatid cyst, lipopeliosis, adrenal rest tumor, pseudolipoma, hepatic teratoma, pericaval fat, extramedullary hematopoiesis, and metastases) or intracellular lipid (i.e., focal steatosis, adenoma, focal nodular hyperplasia, regenerative nodules, and hepatocellular carcinoma).
  • CT, MRI, and sonographic findings of these lesions can help in characterization by allowing specific diagnosis or narrowing the differential diagnosis of liver lesions.
  • [MeSH-major] Fatty Liver / diagnosis. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging. Neoplasms, Adipose Tissue / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 15788580.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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16. Lim SH, Feng L, Kemling JW, Musto CJ, Suslick KS: An optoelectronic nose for the detection of toxic gases. Nat Chem; 2009 Oct;1(7):562-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The sensor consists of a disposable array of cross-responsive nanoporous pigments with colours that are changed by diverse chemical interactions with analytes.
  • Different TICs were identified readily using a standard chemometric approach (hierarchical clustering analysis), with no misclassifications over 140 trials.

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  • (PMID = 20160982.001).
  • [ISSN] 1755-4349
  • [Journal-full-title] Nature chemistry
  • [ISO-abbreviation] Nat Chem
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES016011-03; United States / NIEHS NIH HHS / ES / U01 ES016011; United States / NIEHS NIH HHS / ES / U01 ES016011-03; United States / NIEHS NIH HHS / ES / U01ES016011
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gases
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17. Kacerovský M, Drahosová M, Hornychová H, Plísková L, Bolehovská R, Förstl M, Tosner J, Lesko D, Andrýs C: [Amniotic fluid interleukin 6 levels in preterm premature rupture of membranes]. Ceska Gynekol; 2009 Dec;74(6):403-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: The purpose of this study was to determinate the changes of amniotic fluid interleukin 6 (IL-6) concentrations in patients with preterm premature rupture of the membranes (PPROM), and in the presence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA).
  • The aim was to examine amniotic fluid IL-6 in relation to MIAC and HCA.
  • Twenty-eight of 37 patients placentas were collected and assessed for presence or absence HCA.
  • RESULTS: There was significant difference in the median amniotic fluid IL-6 concentration between patients with preterm rupture of the membranes with and without MIAC and HCA (patients with MIAC and HCA: median 915 pg/ml, range 651-1854 pg/ml vs. patients without MIAC and HCA: median 780 pg/ml, range 184-1059 pg/ml; p=0.047).
  • There was no significant difference in the median amniotic fluid IL-6 concentration between patients with preterm rupture of the membranes with and without HCA (patients with HCA: median 829 pg/ml, range 195-1992 pg/ml vs. patients without HCA: median 768 pg/ml, range 184-1890 pg/ml; p = 0.31).
  • CONCLUSION: Amniotic fluid IL-6 concentrations patients with PPROM with presence HCA and MIAC were significantly higher than IL-6 concentration patients without HCA and MIAC.

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  • (PMID = 21246786.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] CZE
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Interleukin-6
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18. Renaud S, Hays AP, Brannagan TH 3rd, Sander HW, Edgar M, Weimer LH, Olarte MR, Dalakas MC, Xiang Z, Danon MJ, Latov N: Gene expression profiling in chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol; 2005 Feb;159(1-2):203-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups.
  • Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis.
  • [MeSH-minor] Adult. Aged. Chronic Disease. Female. Humans. Male. Middle Aged. Oligonucleotide Array Sequence Analysis / methods. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction / genetics. Sural Nerve / pathology. Up-Regulation


19. Silva AR, Fragoso AC, Oliveira M, Costa-Maia J, Estevão-Costa, Bessa-Monteiro A, Campos M: [Laparoscopic excision of a hepatic mesothelial cyst]. Cir Pediatr; 2009 Oct;22(4):229-32
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  • [Title] [Laparoscopic excision of a hepatic mesothelial cyst].
  • [Transliterated title] Escisión laparoscópica de quiste mesotelial hepático.
  • Over the past few years there has been an increase in application of minimally invasive techniques in pediatric surgery, especially in the approach of liver lesions.
  • The authors present the clinical case of a three year old child, referred to our institution after an incidental finding of a liver cystic lesion in abdominal ultrasound.
  • The MRI confirmed the presence of the cystic lesion and pointed, as a possible etiology, a cystic cyst adenoma of the liver.
  • The anatomo-pathological and immunohistochemical studies concluded it was a mesotelial cyst of the liver.
  • The mesothelial cysts of the liver are very rare lesions, with difficult preoperative diagnosis.
  • [MeSH-major] Cysts / surgery. Hepatectomy / methods. Laparoscopy. Liver Diseases / surgery

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  • (PMID = 20405662.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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20. Puangsombat K, Smith JS: Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary. J Food Sci; 2010 Mar;75(2):T40-7
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  • Heterocyclic amines (HCAs) are mutagenic compounds formed during cooking muscle foods at high temperature.
  • Inhibition of HCAs by rosemary extracts were evaluated with beef patties cooked at 191 degrees C (375 degrees F) for 6 min each side and 204 degrees C (400 degrees F) for 5 min each side.
  • The 5 extracts were directly added to beef patties at 3 levels (0.05%, 0.2%, and 0.5%) before cooking and HCA contents were extracted and quantified.
  • There was no statistical difference in the inhibition of HCAs in the 0.05%, 0.2%, and 0.5% rosemary extracts.
  • When cooking at 204 degrees C (400 degrees F) for 5 min each side, rosemary extracts 10E and 20E were superior to rosemary extracts 100W, 30E, and 40E in inhibiting HCA formation.
  • The inhibiting effect of rosemary extracts on HCA formation corresponded to their antioxidant activity based on a DPPH scavenging assay.
  • It is possible that these compounds might act synergistically in inhibiting the formation of HCAs.
  • [MeSH-major] Antioxidants / pharmacology. Heterocyclic Compounds, 2-Ring / analysis. Meat Products / analysis. Plant Extracts / pharmacology. Rosmarinus
  • [MeSH-minor] Animals. Cattle. Cooking / methods. Ethanol. Food Analysis / methods. Food Handling / methods. Gas Chromatography-Mass Spectrometry / methods. Imidazoles / analysis. Quinoxalines / analysis. Solid Phase Microextraction / methods. Time Factors. Water

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  • (PMID = 20492265.001).
  • [ISSN] 1750-3841
  • [Journal-full-title] Journal of food science
  • [ISO-abbreviation] J. Food Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Heterocyclic Compounds, 2-Ring; 0 / Imidazoles; 0 / Plant Extracts; 0 / Quinoxalines; 059QF0KO0R / Water; 3K9958V90M / Ethanol; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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21. Zucman-Rossi J: Human and mouse hepatocellular adenoma and carcinoma display similar tumorigenesis pathway alterations. J Hepatol; 2008 May;48(5):884-6
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  • [Title] Human and mouse hepatocellular adenoma and carcinoma display similar tumorigenesis pathway alterations.
  • [MeSH-major] Adenoma, Liver Cell / etiology. Carcinoma, Hepatocellular / etiology. Liver Neoplasms / etiology. Liver Neoplasms, Experimental / etiology

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  • [CommentOn] Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6 [17785413.001]
  • (PMID = 18314218.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hepatocyte Nuclear Factor 1-alpha; EC 2.7.10.1 / Proto-Oncogene Proteins c-met
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22. Silva JP, Fonseca Ld, Baumgratz JF, Castro RM, Franchi SM, Lianza AC, Vila JH: Hypoplastic left heart syndrome: the report of a surgical strategy and comparative results of Norwood x Norwood-Sano approach. Rev Bras Cir Cardiovasc; 2007 Apr-Jun;22(2):160-8
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  • [Title] Hypoplastic left heart syndrome: the report of a surgical strategy and comparative results of Norwood x Norwood-Sano approach.
  • OBJECTIVES: To report a surgical strategy for the Norwood procedure in the hypoplastic left heart syndrome (HLHS) that enables short hypothermic circulatory arrest time and aortic arch reconstruction with autologous pericardium patch.
  • Cannulation of the ductus arteriosus for systemic perfusion was the main part of the surgical strategy to reduce the hypothermic circulatory arrest time.
  • Hypothermic circulatory arrest times were 45.79+/-1.99 min and 36,8+/-1,52 min (p=0,0012), respectively.
  • CONCLUSIONS: This surgical strategy resulted in short circulatory arrest time, low mortality and low incidence of aortic coarctation.
  • [MeSH-major] Aortic Valve / surgery. Bioprosthesis. Heart Valve Prosthesis / standards. Hypoplastic Left Heart Syndrome / surgery. Pericardium / transplantation
  • [MeSH-minor] Anastomosis, Surgical. Brazil / epidemiology. Female. Heart Valve Prosthesis Implantation / mortality. Heart Ventricles / surgery. Humans. Infant, Newborn. Length of Stay. Male. Pulmonary Artery / surgery. Pulmonary Circulation. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17992320.001).
  • [Journal-full-title] Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular
  • [ISO-abbreviation] Rev Bras Cir Cardiovasc
  • [Language] eng; por
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Brazil
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23. Apostolakis E, Shuhaiber JH: Antegrade or retrograde cerebral perfusion as an adjunct during hypothermic circulatory arrest for aortic arch surgery. Expert Rev Cardiovasc Ther; 2007 Nov;5(6):1147-61
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  • [Title] Antegrade or retrograde cerebral perfusion as an adjunct during hypothermic circulatory arrest for aortic arch surgery.
  • Three methods of cerebral protection have been applied between 1975 and today: hypothermic circulatory arrest as a basic method, either alone or with antegrade cerebral perfusion (ACP), or retrograde cerebral perfusion (RCP) as an adjunctive method.
  • ACP obtains a near-physiologic brain perfusion, with homogenous distribution of blood throughout the capillary beds, and extends the safe time of hypothermic circulatory arrest to 80 min, allowing the completion of whatever aortic arch work is necessary.

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  • (PMID = 18035930.001).
  • [ISSN] 1744-8344
  • [Journal-full-title] Expert review of cardiovascular therapy
  • [ISO-abbreviation] Expert Rev Cardiovasc Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 92
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24. Ge M, Zhao H, Wang W, Zhang Z, Yu X, Li W: Terahertz time-domain spectroscopy of four hydroxycinnamic acid derivatives. J Biol Phys; 2006 Nov;32(5):403-12
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  • The well-resolved absorption spectra of the hydroxycinnamic acid (HCA) derivatives, caffeic acid, ferulic acid, sinapic acid and chlorogenic acid, were measured over the frequency region from 0.3 to 2.0 THz at 294 K with terahertz time-domain spectroscopy (THz-TDS).
  • Theoretical calculation was applied to assist the analysis and assignment of the individual THz absorption spectra of the HCA derivatives with density functional theory (DFT).
  • The real and imaginary parts of dielectric function of the four HCA derivatives were also obtained.

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  • [Cites] J Phys Chem A. 2006 Feb 9;110(5):1951-9 [16451029.001]
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  • (PMID = 19669446.001).
  • [ISSN] 0092-0606
  • [Journal-full-title] Journal of biological physics
  • [ISO-abbreviation] J Biol Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2651536
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25. Farges O, Dokmak S: Malignant transformation of liver adenoma: an analysis of the literature. Dig Surg; 2010;27(1):32-8
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  • [Title] Malignant transformation of liver adenoma: an analysis of the literature.
  • As adenoma in other locations, hepatic adenoma (HA) may transform into hepatocellular carcinoma (HCC) and hepatocyte dysplasia is most probably the intermediate step between both conditions.
  • This figure however does not take into account fully transformed HA where evidence of the preexisting benign lesion might have disappeared.
  • [MeSH-major] Adenoma / pathology. Cell Transformation, Neoplastic / pathology. Liver Neoplasms / pathology

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20357449.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 42
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26. Lubner M, Menias C, Rucker C, Bhalla S, Peterson CM, Wang L, Gratz B: Blood in the belly: CT findings of hemoperitoneum. Radiographics; 2007 Jan-Feb;27(1):109-25
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  • In the trauma setting, evidence of intraperitoneal blood depicted at computed tomography (CT) should lead the radiologist to conduct a careful search of images for the injured visceral organ (the liver or spleen).
  • Tumor-associated hemorrhage, which most often occurs in hepatocellular carcinoma, hepatic adenoma, or vascular metastatic disease, also may produce hemoperitoneum.
  • Other potential causes of nontraumatic hemoperitoneum are gynecologic conditions such as hemorrhage or rupture of an ovarian cyst and rupture of the gestational sac in ectopic pregnancy, and hepatic hematoma in syndromic hemolysis with elevated liver enzymes and low platelet count (HELLP syndrome).
  • [MeSH-major] Hemoperitoneum / etiology. Hemoperitoneum / radiography. Liver Diseases / radiography. Radiographic Image Enhancement / methods. Splenic Diseases / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Diagnosis, Differential. Humans. Practice Guidelines as Topic. Practice Patterns, Physicians'

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  • [Copyright] Copyright RSNA, 2007.
  • (PMID = 17235002.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 74
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27. Duffin C: Healthcare assistants seen as more involved in patient care than nurses. Nurs Stand; 2006 Aug 16;20(49):5
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  • Patients have said that healthcare assistants (HCAs), not nurses, give most of the direct care they receive in hospital, research published in this week's Nursing Standard reveals.

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  • (PMID = 28086443.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. Shum-Tim D, MacDonald D, Takayuki S, Laliberté E, Chen J, Jamal AM, Philip A, Platt R: Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest. Pediatr Crit Care Med; 2005 May;6(3):319-26
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  • [Title] Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest.
  • OBJECTIVE: The objective of this study was to evaluate the systemic and cerebral effects of different postoperative hematocrit management following cardiopulmonary bypass and deep hypothermic circulatory arrest.
  • INTERVENTIONS: Twelve piglets were subjected to cardiopulmonary bypass (hematocrit = 25%) and 100 mins of deep hypothermic circulatory arrest (15 degrees C).
  • Near-infrared spectroscopy and immunohistochemical assays for cerebral transforming growth factor-beta(1) and caspase-3 were performed.
  • CONCLUSIONS: Lower postoperative hematocrit was associated with increased fluid retention, lower perfusion pressure, and worse cerebrovascular injury following deep hypothermic circulatory arrest.
  • Postoperative hematocrit management may have profound systemic and cerebral effects after deep hypothermic circulatory arrest and merits further investigation.

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  • (PMID = 15857532.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins; 0 / Oxyhemoglobins; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1; 9008-02-0 / deoxyhemoglobin; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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29. Halstead JC, Etz C, Meier DM, Zhang N, Spielvogel D, Weisz D, Bodian C, Griepp RB: Perfusing the cold brain: optimal neuroprotection for aortic surgery. Ann Thorac Surg; 2007 Sep;84(3):768-74; discussion 774
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  • We used a survival porcine model to explore the physiologic characteristics and behavioral benefits of various protocols involving hypothermic circulatory arrest (HCA) and SCP.
  • METHODS: Thirty pigs (26.3 +/- 1.4 kg), cooled to 15 degrees C on cardiopulmonary bypass, using alpha-stat pH management (mean hematocrit 30%), were randomly allocated to differing brain protection strategies: 90 minutes of HCA (group A); 30 minutes of HCA, then 60 minutes of SCP (group B); or 90 minutes of SCP (group C).
  • RESULTS: Cerebral blood flow was significantly higher (p = 0.0001) during SCP (60 and 90 minutes) if preceded by HCA.
  • However, an initial period of HCA does not seem to impair late outcome; perhaps the elevated CBF and CMRO2 observed reflect a beneficial cerebral response to a recoverable insult.
  • Clearly, 90 minutes of HCA induces permanent brain injury, even in this carefully controlled setting.
  • [MeSH-major] Aorta / surgery. Cerebrovascular Circulation. Heart Arrest, Induced

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  • (PMID = 17720373.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] S88TT14065 / Oxygen
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30. Brandt K, Langhans W, Geary N, Leonhardt M: Beneficial and deleterious effects of hydroxycitrate in rats fed a high-fructose diet. Nutrition; 2006 Sep;22(9):905-12
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  • OBJECTIVE: The present study assessed whether long-term supplementation of a high-fructose diet with hydroxycitrate (HCA), an inhibitor of de novo lipogenesis that is widely used as a non-prescription dietary aid, decreases food intake, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats.
  • METHODS: We examined the effects of HCA (1.8% of diet) on food intake, body weight gain, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats during a 4-wk period of ad libitum access to a 50% fructose diet after a 3-wk period of food restriction in which they lost about 20% of their body weight.
  • RESULTS: HCA decreased food intake and weight gain throughout the test and reduced visceral fat accumulation compared with control rats fed ad libitum (CON).
  • Rats that were pair-fed (PF) to the HCA rats showed similar decreases in weight gain and visceral fat.
  • HCA did not ameliorate the hypertriglyceridemia induced by high-fructose feeding.
  • HCA improved insulin sensitivity on day 10 in comparison with CON rats, but by day 27 insulin levels were similarly higher and liver glycogen levels were similarly lower in HCA and CON rats in comparison with PF rats.
  • Liver lipid content was elevated in HCA rats compared with CON and PF rats.
  • CONCLUSION: These findings indicate that, although HCA attenuates body weight gain and visceral fat accumulation by reducing food intake under these conditions, it has no lasting beneficial effects on hypertriglyceridemia and hyperinsulinemia and leads to the accumulation of liver lipids.
  • [MeSH-major] Citrates / administration & dosage. Energy Intake / drug effects. Fructose / administration & dosage. Intra-Abdominal Fat / drug effects. Liver / metabolism. Weight Gain / drug effects

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  • (PMID = 16829028.001).
  • [ISSN] 0899-9007
  • [Journal-full-title] Nutrition (Burbank, Los Angeles County, Calif.)
  • [ISO-abbreviation] Nutrition
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Citrates; 30237-26-4 / Fructose; 8W94T9026R / hydroxycitric acid
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31. Meybohm P, Hoffmann G, Renner J, Boening A, Cavus E, Steinfath M, Scholz J, Bein B: Measurement of blood flow index during antegrade selective cerebral perfusion with near-infrared spectroscopy in newborn piglets. Anesth Analg; 2008 Mar;106(3):795-803, table of contents
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Neonates with complex congenital heart defects have traditionally undergone surgery during deep hypothermic cardiac arrest (HCA).
  • We investigated SCP with different flow rates compared with HCA with respect to cerebral perfusion and tissue oxygenation as assessed by near-infrared spectroscopy.
  • METHODS: Twenty-one piglets were placed on cardiopulmonary bypass at 18 degrees C, then underwent either HCA or SCP at 25 or 50 mL x kg(-1) x min(-1) for 90 min.
  • RESULTS: Both BFI and FV(mean) increased significantly (126 +/- 27% of baseline; 19 +/- 2 cm/s) in the SCP 50 group compared with HCA (no flow) and SCP 25 (65 +/- 24%; 10 +/- 1 cm/s), respectively.
  • TOI increased in the SCP 50 group compared with baseline (74 +/- 4% vs 65 +/- 4%), and was higher compared with HCA (52 +/- 2%) and SCP 25 (59 +/- 2%).
  • CONCLUSIONS: Both BFI and FV(mean) suggested increased cerebral perfusion in the SCP 50 group compared with the HCA and SCP 25 groups.
  • TOI was significantly higher in both the SCP 25 and SCP 50 groups compared with HCA.
  • [MeSH-major] Brain / blood supply. Brain Ischemia / prevention & control. Cardiopulmonary Bypass / adverse effects. Cerebrovascular Circulation. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Monitoring, Intraoperative / methods. Perfusion / methods. Spectroscopy, Near-Infrared


32. Nishimura O, Suzuki T, Hosoba S, Takashima N, Hiramatsu N, Kinoshita T, Kambara A, Matsubayashi K, Asai T: [Acute type A aortic dissection, developed shortly after aortic valve replacement and coronary artery bypass grafting]. Kyobu Geka; 2010 Dec;63(13):1141-4
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  • Under hypothermic circulatory arrest with femoral arterial and venous cannulations, the ascending aorta was replaced and re-implantation of the saphenous vein graft was carried out.
  • [MeSH-major] Aneurysm, Dissecting / etiology. Aortic Aneurysm, Thoracic / etiology. Coronary Artery Bypass. Heart Valve Prosthesis Implantation
  • [MeSH-minor] Acute Disease. Aged. Angina Pectoris / surgery. Aortic Valve Insufficiency / surgery. Humans. Male. Postoperative Complications. Reoperation

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  • (PMID = 21174664.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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33. De Francesco MA, Gargiulo F, Schreiber C, Ciravolo G, Salinaro F, Manca N: Detection and genotyping of human papillomavirus in cervical samples from Italian patients. J Med Virol; 2005 Apr;75(4):588-92
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  • In order to assess the epidemiological incidence and frequency of different HPV types, we applied a polymerase chain reaction (PCR)-direct sequencing approach based on the use of MY09/MY11 primers as compared to Hybrid Capture assay.
  • [MeSH-minor] Adolescent. Adult. Carcinoma in Situ / virology. Female. Genotype. Humans. Italy. Middle Aged. Sequence Analysis, DNA

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15714493.001).
  • [ISSN] 0146-6615
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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34. Galloro V: Emory, HCA to end venture. Cultural differences, control cited as obstacles. Mod Healthc; 2010 Jul 19;40(29):16
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  • [Title] Emory, HCA to end venture. Cultural differences, control cited as obstacles.

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  • (PMID = 20695116.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] United States
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35. Papanikolaou V, Giakoustidis D, Patsiaura K, Imvrios G, Antoniadis N, Ouzounidis N, Nikopolitidis V, Antoniadis A, Takoudas D: Management of a giant ruptured hepatocellular adenoma. Report of a case. Hippokratia; 2007 Apr;11(2):86-8
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  • [Title] Management of a giant ruptured hepatocellular adenoma. Report of a case.
  • This report describes a rare case of a young woman with massive intra-abdominal bleeding due to a giant ruptured hepatocellular adenoma.
  • The patient had never used oral contraceptive pills and she was urgently operated for haemorrhage control in another hospital where the left hepatic artery was also ligated.
  • After haemodynamic stabilization in the ICU and because of a complicated postoperative course (signs of intraabdominal sepsis) she was transferred to our hospital and a left lobectomy was performed.
  • We present the case and comment on the preferred treatment modalities of hepatocellular adenomas.

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  • (PMID = 19582184.001).
  • [ISSN] 1790-8019
  • [Journal-full-title] Hippokratia
  • [ISO-abbreviation] Hippokratia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Other-IDs] NLM/ PMC2464268
  • [Keywords] NOTNLM ; adenoma / giant / hepatocellular / rupture / surgical
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36. De Felice C, Goldstein MR, Parrini S, Verrotti A, Criscuolo M, Latini G: Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis. Pediatr Crit Care Med; 2006 Mar;7(2):138-42
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  • OBJECTIVE: No reliable clinical markers of histologic chorioamnionitis (HCA), a major and often subclinical cause of prematurity leading to high neonatal morbidity and mortality, are available to date.
  • PATIENTS AND INTERVENTION: Pulse oximetry-derived signals (pulse rate, oxygen saturation, and perfusion index), recorded within the first 1.5 hrs of life, were analyzed for 110 very low-birth-weight infants, of whom 54 had histopathological evidence of HCA.
  • MEASUREMENTS AND MAIN RESULTS: Four different time series parameters were determined for nonlinear dynamical (NLD) analysis.
  • Significantly decreased Lempel-Ziv, Lyapunov largest exponent, and correlation dimension, with significantly increased Hurst values for heart rate and perfusion index (p < .00001), were observed in newborns with HCA.
  • Heart rate Lempel-Ziv </=0.218 showed 100% sensitivity (95% confidence interval, 98.8-100) and 100% specificity (95% confidence interval, 98.6-100) in distinguishing cases from controls, with positive and negative predictive values of 100% and 95.7%, respectively.
  • CONCLUSIONS: Our findings indicate that early autonomic tone balance abnormalities are present in newborns with HCA and suggest that early dynamic analysis of pulse oximetry signals could be useful in identifying affected infants.
  • [MeSH-major] Chorioamnionitis / diagnosis. Chorioamnionitis / pathology. Infant, Premature

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  • (PMID = 16474255.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Lehmann U, Berg-Ribbe I, Wingen LU, Brakensiek K, Becker T, Klempnauer J, Schlegelberger B, Kreipe H, Flemming P: Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling. Clin Cancer Res; 2005 May 15;11(10):3654-60
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  • [Title] Distinct methylation patterns of benign and malignant liver tumors revealed by quantitative methylation profiling.
  • PURPOSE: A comparative quantitative methylation profiling of hepatocellular carcinoma and the most frequent benign liver tumor, hepatocellular adenoma, was set up for the identification of tumor-specific methylation patterns.
  • EXPERIMENTAL DESIGN: The quantitative methylation levels of nine genes (RASSF1A, cyclinD2, p16INK4a, DAP-K, APC, RIZ-1, HIN-1, GSTpi1, SOCS-1) were analyzed in hepatocellular carcinoma and adjacent normal tissue (n = 41), hepatocellular adenoma and adjacent normal tissue (n = 26), focal nodular hyperplasia (n = 10), and unrelated normal liver tissue (n = 28).
  • Accumulated methylation data were analyzed using various statistical algorithms, including hierarchical clustering, to detect tumor-specific methylation patterns.
  • RESULTS: Cluster analysis revealed that hepatocellular adenoma displays a methylation profile much more similar to that found in normal liver tissue and focal nodular hyperplasia than to that found in hepatocellular carcinoma.
  • Many characteristic differences were not detected when using mere qualitative methylation assays.
  • The cyclinD2 gene was identified as a new and frequent target for aberrant hypermethylation in hepatocellular carcinoma (68%).
  • In the control group of 28 liver specimens from healthy donors, a clear correlation between age of patient and frequency and level of aberrant methylation was seen, which could not be detected in the group of hepatocellular carcinoma specimens.
  • CONCLUSIONS: Methylation profiling can clearly contribute to the unequivocal classification of suspicious lesions, but only if done in a quantitative manner applying cell type and gene-specific thresholds.
  • In hepatocellular carcinoma, the altered methylation patterns accompanying malignant transformation override the age-dependent increase in gene methylation.
  • [MeSH-major] Adenoma, Liver Cell / genetics. Carcinoma, Hepatocellular / genetics. Cyclins / genetics. DNA Methylation. Liver Diseases / genetics. Liver Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Algorithms. Case-Control Studies. Child. Child, Preschool. Cluster Analysis. Cyclin D2. Diagnosis, Differential. Female. Humans. Infant. Male. Middle Aged. Polymerase Chain Reaction

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  • (PMID = 15897561.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCND2 protein, human; 0 / Cyclin D2; 0 / Cyclins
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38. Trask OJ, Nickischer D, Burton A, Williams RG, Kandasamy RA, Johnston PA, Johnston PA: High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer. Methods Mol Biol; 2009;565:159-86
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  • [Title] High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer.
  • The integration of fluorescent microscopy imaging technologies and image analysis into high-content screening (HCS) has been applied throughout the drug discovery pipeline to identify, evaluate, and advance compounds from early lead generation through preclinical candidate selection.
  • In this chapter we describe the development, validation, and implementation of an HCS assay to screen compounds from a kinase-focused small-molecule library to identify inhibitors of the p38 pathway using the GE InCell 3000 automated imaging platform.
  • The assay utilized a genetically modified HeLa cell line stably expressing mitogen-activated, protein-activating protein kinase-2 fused to enhanced green fluorescent protein (MK2-EGFP) and measured the subcellular distribution of the MK2-EGFP as a direct readout of p38 activation.
  • The MK2-EGFP translocation assay performed in 384-well glass bottom microtiter plates exhibited a robust Z-factor of 0.46 and reproducible EC50 and IC50 determinations for activators and inhibitors, respectively.
  • Thirty-one compounds exhibited IC50s less than 1 microM, and at least one novel structural class of p38 inhibitor was identified using this HCA/HCS chemical biology screening approach.
  • [MeSH-major] Drug Evaluation, Preclinical / methods. Enzyme Inhibitors / analysis. Microscopy, Confocal / methods. p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
  • [MeSH-minor] Calcium / metabolism. HeLa Cells. Humans

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  • (PMID = 19551362.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; SY7Q814VUP / Calcium
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39. Wu Y, Na N, Zhang S, Wang X, Liu D, Zhang X: Discrimination and identification of flavors with catalytic nanomaterial-based optical chemosensor array. Anal Chem; 2009 Feb 1;81(3):961-6
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  • Hierarchical cluster analysis (HCA) and linear discriminant analysis (LDA) were used to analyze the patterns.
  • [MeSH-major] Flavoring Agents / analysis. Luminescent Measurements / methods. Nanostructures / chemistry
  • [MeSH-minor] Catalysis. Discriminant Analysis. Metal Nanoparticles / chemistry. Nanotubes, Carbon / chemistry. Temperature. Time Factors

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  • (PMID = 19119818.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Flavoring Agents; 0 / Nanotubes, Carbon
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40. Popescu I, Vasile S, Sgarbură O, Hrehoreţ D, Tomulescu V: [Laparoscopic left lateral segmentectomy of the liver: indications, technique, results]. Chirurgia (Bucur); 2008 Jan-Feb;103(1):17-22
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  • [Title] [Laparoscopic left lateral segmentectomy of the liver: indications, technique, results].
  • INTRODUCTION: The laparoscopic approach of the hepatic lesions located in the left lobe is a frequently used procedure in liver surgery for both benign and malign tumors because of the minimal invasive character, anatomical particularities and modem devices used in hemostasis and biliary-stasis.
  • RESULTS: Between 1998-2007 we performed 84 laparoscopic hepatic resections out of which 20 were located in the left liver lobe.
  • The hepatic lesions approached laparoscopically were both benign (5 cases out of which 3 hemangioma and 2 adenoma) and malignant (7 cases hepatocellular carcinoma).
  • [MeSH-major] Hepatectomy / methods. Laparoscopy. Liver Neoplasms / surgery
  • [MeSH-minor] Adenoma / surgery. Aged. Carcinoma, Hepatocellular / surgery. Cohort Studies. Digestive System Surgical Procedures / methods. Female. Hemangioma / surgery. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 18459493.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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41. Basaran I, Sinan S, Cakir U, Bulut M, Arslan O, Ozensoy O: In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds. J Enzyme Inhib Med Chem; 2008 Feb;23(1):32-6
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  • These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B.

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  • (PMID = 18341250.001).
  • [ISSN] 1475-6366
  • [Journal-full-title] Journal of enzyme inhibition and medicinal chemistry
  • [ISO-abbreviation] J Enzyme Inhib Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Coumarins; 0 / Enzyme Inhibitors; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II
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42. Herszényi L, István G, Cardin R, De Paoli M, Plebani M, Tulassay Z, Farinati F: Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers. Eur J Cancer Prev; 2008 Oct;17(5):438-45
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  • Serum CATB and plasma UPA levels were determined by enzyme-linked immunoadsorbent assay and their sensitivity, specificity, and diagnostic accuracy have been calculated in patients with colorectal (n=72), gastric (n=30), hepatocellular (n=28), and pancreatic cancer (n=15) as well as in gastric epithelial dysplasia (n=25), colorectal adenomas (n=30), and tumor-free control patients (n=44).
  • CATB and UPA were significantly higher in patients with gastric epithelial dysplasia and colorectal adenomas than in controls.
  • [MeSH-major] Adenoma / blood. Carcinoma / blood. Cathepsin B / blood. Gastrointestinal Neoplasms / blood. Urokinase-Type Plasminogen Activator / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Prognosis. Sensitivity and Specificity

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  • (PMID = 18714186.001).
  • [ISSN] 1473-5709
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.4.21.73 / Urokinase-Type Plasminogen Activator; EC 3.4.22.1 / Cathepsin B
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43. Fichera A, Little N, Dougherty U, Mustafi R, Cerda S, Li YC, Delgado J, Arora A, Campbell LK, Joseph L, Hart J, Noffsinger A, Bissonnette M: A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model. J Surg Res; 2007 Oct;142(2):239-45
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  • Our aim was to evaluate the anti-inflammatory and chemopreventive efficacy of the vitamin D analogue Ro26-2198 in the AOM/DSS model and in vitro in HCA-7 colon cancer cells.
  • For in vitro studies, HCA-7 cells were treated with Ro26-2198 followed by interleukin-1beta (IL-1beta).
  • Proliferation was measured by WST-1 assay.
  • In vitro, Ro26-2198 inhibited IL-1beta-induced ERK activation and COX-2 induction and decreased HCA-7 cell proliferation.
  • [MeSH-minor] Animals. Anti-Inflammatory Agents / pharmacology. Cell Division / drug effects. Cell Line, Tumor. Colon / metabolism. Colon / pathology. Cyclooxygenase 2 / metabolism. Disease Models, Animal. Extracellular Signal-Regulated MAP Kinases / metabolism. Humans. Interleukin-1beta / pharmacology. MAP Kinase Signaling System / drug effects. Male. Mice. Mice, Inbred A. Proto-Oncogene Proteins c-myc / metabolism. Up-Regulation / drug effects

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  • (PMID = 17574271.001).
  • [ISSN] 0022-4804
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA036745; United States / NIDDK NIH HHS / DK / DK42086
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3; 0 / Anti-Inflammatory Agents; 0 / Interleukin-1beta; 0 / Proto-Oncogene Proteins c-myc; 1C6V77QF41 / Cholecalciferol; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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44. Ueda T, Taguchi S, Inoue Y, Kashima I: Hypothermic circulatory arrest through a left thoracotomy in a 12-year-old child with aortic coarctation. Interact Cardiovasc Thorac Surg; 2007 Feb;6(1):85-6
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  • [Title] Hypothermic circulatory arrest through a left thoracotomy in a 12-year-old child with aortic coarctation.
  • Surgical correction of adult complex aortic coarctation using hypothermic circulatory arrest often requires central cannulation to secure cerebral perfusion.
  • [MeSH-major] Aortic Coarctation / surgery. Heart Arrest, Induced. Hypothermia, Induced. Thoracotomy / methods

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  • (PMID = 17669776.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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45. National Toxicology Program: NTP carcinogenesis studies of 2,2-bis(bromomethyl)-1,3-propanediol, nitromethane, and 1,2,3-trichloropropane (cas nos. 3296-90-0, 75-52-5, and 96-18-4) in guppies (Poecilia reticulata) and medaka (Oryzias latipes) (Waterborne Studies). Natl Toxicol Program Tech Rep Ser; 2005 Oct;(528):1-190
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  • Ten guppies and 10 medaka from each group replicate were sacrificed at 9 months for histopathologic analysis.
  • The sex of guppies and medaka was determined at histopathologic analysis.
  • At 9 months, hepatocellular adenomas occurred in one 24 mg/L male and in one 150 mg/L male.
  • In the core study, the incidence of hepatocellular adenoma or carcinoma (combined) in 150 mg/L males was greater than that in the controls; multiple adenomas occurred in two 150 mg/L males and in one 150 mg/L female.
  • In the stop-exposure study, incidences of hepatocellular adenoma (including multiple) and of hepatocellular carcinoma were greater in 150 mg/L males than in controls.
  • In the core study, the incidence of hepatocellular adenoma or carcinoma (combined) was increased in 150 mg/L males.
  • In the stop-exposure study, incidences of hepatocellular adenoma or carcinoma (combined) were marginally increased in the 150 mg/L group of males and in the 60 and 150 mg/L groups of females as compared with controls.
  • Due to the high mortality of fish in the 70 mg/L core study groups, these fish were removed from treatment (day 396) and fixed for histological analyses after approximately 57 weeks on study.
  • The biological significance of this finding is unknown.
  • Hepatocellular adenomas occurred in two 20 mg/L males and in one 40 mg/L female.
  • At 9 months, multiple hepatocellular adenomas occurred in one 4.5 mg/L male, and one hepatocellular adenoma occurred in a control male.
  • In the core study, increased incidences of cholangiocellular (bile duct) and hepatocellular neoplasms occurred in exposed groups of males and females.
  • In the stop-exposure study, increased incidences of hepatocellular neoplasms occurred in 18.0 mg/L males and increased incidences of cholangiocellular (bile duct) neoplasms occurred in 18.0 mg/L females. (ABSTRACT TRUNCATED)
  • [MeSH-major] Carcinogens / toxicity. Liver Neoplasms / chemically induced. Methane / analogs & derivatives. Nitroparaffins / toxicity. Propane / analogs & derivatives. Propylene Glycols / toxicity. Water Pollutants, Chemical / toxicity

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  • (PMID = 16362062.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Nitroparaffins; 0 / Propylene Glycols; 0 / Water Pollutants, Chemical; 3296-90-0 / 2,2-bis(bromomethyl)-1,3-propanediol; 3MJ7QCK0Z0 / 1,2,3-trichloropropane; OP0UW79H66 / Methane; RU5WG8C3F4 / nitromethane; T75W9911L6 / Propane
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46. Muniz Filho RC, de Sousa SA, Pereira Fda S, Ferreira MM: Theoretical study of acid-catalyzed hydrolysis of epoxides. J Phys Chem A; 2010 Apr 22;114(15):5187-94
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  • By using chemometric tools, hierarchical cluster analysis (HCA), and principal component analysis (PCA), the MP2/6-311++G** level of theory was selected from HF, MP2, and DFT as the best method to describe the geometry of the basic skeleton (oxirane).
  • In the S(N)1 mechanism, the existence of the typical carbocation was not observed, and furthermore, the possibility of epoxide conversion to a protonated aldehyde was indicated, even in the presence of a water molecule (nucleophile).

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  • (PMID = 20334442.001).
  • [ISSN] 1520-5215
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Evert M, Schneider-Stock R, Dombrowski F: Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat. Lab Invest; 2005 Jan;85(1):99-108
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  • Fatty acid synthase (FAS) is the key enzyme of de novo fatty acid synthesis and has been shown to be involved in carcinogenesis of numerous human malignancies, including breast, colorectal, and prostate carcinomas, often associated with a worse prognosis.
  • Although FAS is mainly expressed in the liver, an implication of FAS in hepatocarcinogenesis, has not yet been investigated.
  • Preneoplastic clear-cell foci of altered hepatocytes (FAH), harvested after laser-microdissection of kryostat sections, showed an overexpression of FAS messenger RNA in gene expression profiles, done by array-hybridization, and in quantitative RT-PCR (Light-Cycler).
  • Virtually, all (96-98%) of the subsequently investigated FAH and the glycogenotic hepatocellular adenomas and carcinomas showed an additional strong FAS protein overexpression.
  • Basophilic lesions and neoplasms, which occasionally develop out of the primary clear-cell FAH at later stages of carcinogenesis, however, lost FAS overexpression.
  • In conclusion, FAS overexpression is an early phenonemon in spontaneous, hormonally and chemically induced rat hepatocarcinogenesis, demonstrable in early clear-cell (glycogenotic) FAH and hepatocellular neoplasms.
  • [MeSH-major] Adenoma / enzymology. Carcinoma / enzymology. Diabetes Mellitus, Experimental / enzymology. Fatty Acid Synthases / metabolism. Liver Neoplasms, Experimental / enzymology
  • [MeSH-minor] Animals. Disease Models, Animal. Fluorescent Antibody Technique, Indirect. Gene Expression Profiling. Hepatocytes / drug effects. Hepatocytes / enzymology. Hepatocytes / pathology. Islets of Langerhans Transplantation / pathology. Liver / pathology. Male. Precancerous Conditions / chemically induced. Precancerous Conditions / enzymology. Precancerous Conditions / pathology. RNA, Messenger / metabolism. Rats. Rats, Inbred Lew. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15543204.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 2.3.1.85 / Fatty Acid Synthases
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48. Mazzei P, Francesca N, Moschetti G, Piccolo A: NMR spectroscopy evaluation of direct relationship between soils and molecular composition of red wines from Aglianico grapes. Anal Chim Acta; 2010 Jul 19;673(2):167-72
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  • The careful subtraction of water and ethanol signals from NMR spectra allowed to statistically recognize the metabolites to be employed in multivariate statistical methods: Principal Component Analysis (PCA), Discriminant Analysis (DA) and Hierarchical Clustering Analysis (HCA).
  • All multivariate analyses confirmed that the differentiation among the wines were related to micro-climate, and carbonate, clay, and organic matter content of soils.

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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20599031.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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49. Karni M, Bernasconi CF, Rappoport Z: Role of negative hyperconjugation and anomeric effects in the stabilization of the intermediate in SNV reactions. J Org Chem; 2008 Apr 18;73(8):2980-94
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  • The hyperconjugation ability (HCA) (i.e., the stabilization due to 2p(Calpha) --> sigma*(Cbeta-X) interaction) in 8b-8d follows the order (for X, kcal/mol) CH3S (8.5) > CF3CH2O (7.6) approximately CH3O (7.5).
  • The HCA in 8b-8d is significantly smaller than that in 7b-7d due to charge delocalization in Mu in the former.

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  • (PMID = 18376875.001).
  • [ISSN] 0022-3263
  • [Journal-full-title] The Journal of organic chemistry
  • [ISO-abbreviation] J. Org. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Anderl JL, Redpath S, Ball AJ: A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity. J Vis Exp; 2009;(27)
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  • [Title] A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity.
  • High Content Analysis (HCA) assays combine cells and detection reagents with automated imaging and powerful image analysis algorithms, allowing measurement of multiple cellular phenotypes within a single assay.
  • In this study, we utilized HCA to develop a novel assay for neurotoxicity.
  • Recently, the application of HCA to neuronal screening has been reported.
  • By labeling neuronal cells with betaIII-tubulin, HCA assays can provide high-throughput, non-subjective, quantitative measurements of parameters such as neuronal number, neurite count and neurite length, all of which can indicate neurotoxic effects.
  • Astrocytes have an integral role in the maintenance of central nervous system (CNS) homeostasis, and are associated with both neuroprotection and neurodegradation when they are activated in response to toxic substances or disease states.
  • This approach is limited by an inability to provide information on cellular localization, morphology and cell number.
  • We determined that HCA could be used to overcome these limitations and to simultaneously measure multiple features associated with gliosis - changes in GFAP expression, astrocyte hypertrophy, and astrocyte proliferation - within a single assay.
  • Recent studies have suggested that the use of astrocytes in an in vitro neurotoxicity test system may prove more relevant to human CNS structure and function than neuronal cells alone.
  • Accordingly, we have developed an HCA assay for co-culture of neurons and astrocytes, comprised of protocols and validated, target-specific detection reagents for profiling betaIII-tubulin and glial fibrillary acidic protein (GFAP).
  • This assay enables simultaneous analysis of neurotoxicity, neurite outgrowth, gliosis, neuronal and astrocytic morphology and neuronal and astrocytic development in a wide variety of cellular models, representing a novel, non-subjective, high-throughput assay for neurotoxicity assessment.
  • The assay holds great potential for enhanced detection of neurotoxicity and improved productivity in neuroscience research and drug discovery.

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  • (PMID = 19417729.001).
  • [ISSN] 1940-087X
  • [Journal-full-title] Journal of visualized experiments : JoVE
  • [ISO-abbreviation] J Vis Exp
  • [Language] eng
  • [Publication-type] Journal Article; Video-Audio Media
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3253581
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51. Jeon YK, Cheon JE, Kim SK, Wang KC, Cho BK, Park SH: Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization. Mod Pathol; 2008 Nov;21(11):1345-56
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  • [Title] Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization.
  • The presence of a pilomyxoid area was associated with shorter survival.
  • An unsupervised hierarchical clustering analysis classified the cases into three clusters: one pilomyxoid astrocytoma patient into one cluster, two pilomyxoid astrocytoma patients into another cluster, and six pilocytic astrocytoma patients and one pilomyxoid astrocytoma patient into the third cluster.
  • In conclusion, the presence of mixed-form pilomyxoid astrocytoma, the acquisition of pilocytic astrocytoma features in a recurrent tumor in pure-form pilomyxoid astrocytoma, and the above results of the genome-wide gene copy number analysis suggest that pilomyxoid astrocytoma might be a pathologically and genetically related, aggressive variant of pilocytic astrocytoma with partially different genetic alterations.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Brain / pathology. Child. Child, Preschool. Clone Cells. DNA, Neoplasm / genetics. Female. Humans. Immunoenzyme Techniques. Infant. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Survival Rate. Young Adult

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  • (PMID = 18622384.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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52. Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR: Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res; 2007 May 15;67(10):4586-94
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  • [Title] Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis.
  • Hepatocellular carcinoma (HCC) with p53 mutations is usually characterized by extensive chromosomal instability (CIN), whereas those with beta-catenin mutations have relatively less CIN and the molecular pathogenesis of these tumors is unknown.
  • Methylation of 21 genetic loci was quantitated using combined bisulfite restriction analysis.
  • Using hierarchical clustering analysis based upon the quantification of methylation levels, all HCCs were segregated into two groups characterized by either limited or extensive methylation.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. Cell Transformation, Neoplastic / genetics. DNA Methylation. Liver Neoplasms / genetics. beta Catenin / genetics

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  • [ErratumIn] Cancer Res. 2007 Jun 15;67(12):5998. Ajay, Goel [corrected to Goel, Ajay]
  • (PMID = 17510384.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA72851; United States / NCI NIH HHS / CA / R01 CA98572
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / beta Catenin
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53. Panos A, Murith N, Bednarkiewicz M, Khatchatourov G: Axillary cerebral perfusion for arch surgery in acute type A dissection under moderate hypothermia. Eur J Cardiothorac Surg; 2006 Jun;29(6):1036-9
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  • Adequate brain protection is essential and commonly performed by either antegrade selective perfusion of the brachiocephalic arteries or an interval of profound hypothermic circulatory arrest.
  • The mean duration of circulatory arrest of the lower body and brain perfusion was 39.7 (range, 24-55 min).
  • CONCLUSIONS: The absence of any major permanent neurologic deficit or any visceral damages in our patients suggests that continuous moderate hypothermic cerebral perfusion, with an interval of circulatory arrest of the lower body, is adequate for acute type A aortic dissection surgery, allowing safe open repair of the distal aortic arch.
  • [MeSH-minor] Acute Disease. Adult. Aged. Aged, 80 and over. Axillary Artery. Brain Ischemia / prevention & control. Cardiopulmonary Bypass / methods. Catheterization, Peripheral / methods. Female. Humans. Male. Middle Aged. Perfusion / methods. Treatment Outcome

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  • [CommentIn] Eur J Cardiothorac Surg. 2006 Nov;30(5):815-6; author reply 816-7 [16956768.001]
  • [CommentIn] Eur J Cardiothorac Surg. 2006 Jun;29(6):1039-40 [16675223.001]
  • (PMID = 16675240.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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54. Hidayat W, Shakaff AY, Ahmad MN, Adom AH: Classification of agarwood oil using an electronic nose. Sensors (Basel); 2010;10(5):4675-85
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  • Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA), were used to classify different types of oil.
  • The HCA produced a dendrogram showing the separation of e-nose data into three different groups of oils.
  • [MeSH-major] Electronic Nose. Plant Oils / analysis. Thymelaeaceae / chemistry
  • [MeSH-minor] Algorithms. Cluster Analysis. Neural Networks (Computer). Odorants / analysis. Principal Component Analysis

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  • (PMID = 22399899.001).
  • [ISSN] 1424-8220
  • [Journal-full-title] Sensors (Basel, Switzerland)
  • [ISO-abbreviation] Sensors (Basel)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Plant Oils
  • [Other-IDs] NLM/ PMC3292139
  • [Keywords] NOTNLM ; ANN (major topic) / HCA (major topic) / PCA (major topic) / agarwood oil (major topic) / dimensionality reduction (major topic) / e-nose (major topic)
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55. Kang M, Akbarali HI: Denitration of L-type calcium channel. FEBS Lett; 2008 Sep 3;582(20):3033-6
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  • Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCa(v)1.2b.
  • Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Ca(v)1.2 in a 1D gel assay.
  • Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates.

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  • (PMID = 18675806.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK046367-17; United States / NIDDK NIH HHS / DK / R01 DK046367; United States / NIDDK NIH HHS / DK / DK46367; United States / NIDDK NIH HHS / DK / R01 DK046367-17
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CACNA1C protein, human; 0 / Calcium Channels, L-Type; 0 / Nitrates; 3604-79-3 / 3-nitrotyrosine; 42HK56048U / Tyrosine
  • [Other-IDs] NLM/ NIHMS68998; NLM/ PMC2533528
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56. Yan S, Luo G, Wang Y, Cheng Y: Simultaneous determination of nine components in Qingkailing injection by HPLC/ELSD/DAD and its application to the quality control. J Pharm Biomed Anal; 2006 Mar 3;40(4):889-95
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  • This assay was fully validated in respect to precision, repeatability and accuracy.
  • The proposed method was successfully applied to quantify the nine ingredients in 19 different Qingkailing injection samples and by principal component analysis (PCA) and hierarchical clustering analysis (HCA), it demonstrated significant variations in the content of these compounds in the samples from different manufacturers and preparation procedures.
  • [MeSH-minor] Cluster Analysis. Light. Principal Component Analysis. Quality Control. Reproducibility of Results. Scattering, Radiation. Spectrophotometry, Ultraviolet

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  • (PMID = 16257167.001).
  • [ISSN] 0731-7085
  • [Journal-full-title] Journal of pharmaceutical and biomedical analysis
  • [ISO-abbreviation] J Pharm Biomed Anal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Qingkailing
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57. Galusca B, Dumollard JM, Lassandre S, Niveleau A, Prades JM, Estour B, Peoc'h M: Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia. Virchows Arch; 2005 Jul;447(1):18-23
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  • [Title] Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia.
  • The study aimed to evaluate the status of global DNA methylation in several types of thyroid tumors using a monoclonal antibody specific for 5-methylcytidine (5-mc) and to define the diagnosis potential of this marker.
  • 5-mc immunostaining scores were calculated in 17 papillary thyroid carcinomas (PTC), 6 follicular thyroid carcinomas (FTC), 16 follicular adenomas (FA), 19 nodular goiters (NG) and ten Hürthle cells adenomas (HCA).
  • Computerized image analysis showed a significant lower level of 5-mc immunostaining in thyroid carcinoma when compared with benign tumors or adjacent normal thyroid parenchyma (P<0.0001).
  • Overall, 5-mc accuracy to distinguish malign from benign thyroid tumors was similar to that of galectin-3 (89% versus 87%, P>0.05).
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. DNA Methylation. Goiter, Nodular / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Epigenesis, Genetic. Galectin 3 / analysis. Humans. Image Processing, Computer-Assisted. Immunohistochemistry. Reproducibility of Results

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  • (PMID = 15891902.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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58. Pelletier L, Rebouissou S, Paris A, Rathahao-Paris E, Perdu E, Bioulac-Sage P, Imbeaud S, Zucman-Rossi J: Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis. Hepatology; 2010 Feb;51(2):557-66
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  • [Title] Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis.
  • Hepatocellular adenomas (HCAs) are benign liver tumors that usually develop in women who are taking oral contraceptives.
  • Among these tumors, biallelic inactivating mutations of the hepatocyte nuclear factor 1alpha (HNF1A) transcription factor have been frequently identified and in rare cases of hepatocellular carcinomas developed in noncirrhotic liver.
  • Because HNF1A meets the genetic criteria of a tumor suppressor gene, we aimed to elucidate the tumorigenic mechanisms related to HNF1alpha inactivation in hepatocytes.
  • We searched for signaling pathways aberrantly activated in human HNF1A-mutated HCA (H-HCA) using a genome-wide transcriptome analysis comparing five H-HCA with four normal livers.
  • We validated the main pathways by quantitative reverse transcription polymerase chain reaction (RT-PCR) and western blotting in a large series of samples.
  • Then, we assessed the role of HNF1alpha in the observed deregulations in hepatocellular cell models (HepG2 and Hep3B) by silencing its endogenous expression using small interfering RNA.
  • Along with the previously described induction of glycolysis and lipogenesis, H-HCA also displayed overexpression of several genes encoding growth factor receptors, components of the translation machinery, cell cycle, and angiogenesis regulators, with, in particular, activation of the mammalian target of rapamycin (mTOR) pathway.
  • Moreover, estradiol detoxification activities were shut down, suggesting a hypersensitivity of H-HCA to estrogenic stimulation.
  • In the cell model, inhibition of HNF1alpha recapitulated most of these identified transcriptional deregulations, demonstrating that they were related to HNF1alpha inhibition.
  • CONCLUSION: H-HCA showed a combination of alterations related to HNF1alpha inactivation that may cooperate to promote tumor development.
  • Interestingly, mTOR appears as a potential new attractive therapeutic target for treatment of this group of HCAs.
  • [MeSH-major] Adenoma, Liver Cell / etiology. Hepatocyte Nuclear Factor 1-alpha / physiology. Liver Neoplasms / etiology. Signal Transduction
  • [MeSH-minor] Cell Line, Tumor. Gene Expression Regulation, Neoplastic. Humans. Tumor Cells, Cultured

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  • (PMID = 20041408.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hepatocyte Nuclear Factor 1-alpha
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59. Kaakinen T, Alaoja H, Heikkinen J, Dahlbacka S, Laurila P, Kiviluoma K, Salomäki T, Tuominen H, Ohtonen P, Biancari F, Juvonen T: Hypertonic saline dextran improves outcome after hypothermic circulatory arrest: a study in a surviving porcine model. Ann Thorac Surg; 2006 Jan;81(1):183-90
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  • [Title] Hypertonic saline dextran improves outcome after hypothermic circulatory arrest: a study in a surviving porcine model.
  • In the present study we have assessed its potential neuroprotective efficacy in the setting of hypothermic circulatory arrest in a surviving porcine model.
  • METHODS: Twenty-four pigs were randomized to receive two 5-minute intravenous infusions (4 mL/kg) of either HSD (7.5 % saline, 6% dextran 70) or normal saline immediately after and 4 hours after a 75-minute period of hypothermic circulatory arrest at a brain temperature of 18 degrees C.
  • Intracranial pressure was lower in the HSD group from 45 minutes to 8 hours after hypothermic circulatory arrest (p = 0.03).
  • Cerebral perfusion pressure was higher in the HSD group from 45 minutes to 3 hours after hypothermic circulatory arrest (p = 0.06).
  • CONCLUSIONS: The use of HSD in experimental hypothermic circulatory arrest is associated with significantly better neurologic recovery, better histopathology, lower intracranial pressure, higher cerebral perfusion pressure, and better preservation of brain metabolism.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Dextrans / therapeutic use. Hypoxia-Ischemia, Brain / etiology. Neuroprotective Agents / therapeutic use. Reperfusion Injury / prevention & control. Saline Solution, Hypertonic / therapeutic use. Sodium Chloride / therapeutic use
  • [MeSH-minor] Animals. Behavior, Animal / drug effects. Body Temperature. Brain / pathology. Brain Chemistry. Cardiopulmonary Bypass / adverse effects. Drug Administration Schedule. Drug Evaluation, Preclinical. Female. Glucose / analysis. Infusions, Intravenous. Intracranial Pressure / drug effects. Lactates / analysis. Oxygen / analysis. Partial Pressure. Pyruvates / analysis. Random Allocation. Sus scrofa

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  • [CommentIn] Ann Thorac Surg. 2006 Jan;81(1):190 [16368361.001]
  • (PMID = 16368360.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Lactates; 0 / Neuroprotective Agents; 0 / Pyruvates; 0 / Saline Solution, Hypertonic; 0 / hypertonic saline-dextran solution; 451W47IQ8X / Sodium Chloride; IY9XDZ35W2 / Glucose; K3R6ZDH4DU / Dextrans; S88TT14065 / Oxygen
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60. Liu ZG, Sun LZ, Chang Q, Zhu JM, Dong C, Yu CT, Liu YM, Zhang HT: Should the "elephant trunk" be skeletonized? Total arch replacement combined with stented elephant trunk implantation for Stanford type A aortic dissection. J Thorac Cardiovasc Surg; 2006 Jan;131(1):107-13
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  • The stented graft, a 10-cm-long woven Dacron graft with a self-expandable stent, was implanted through the aortic arch during hypothermic circulatory arrest.
  • RESULTS: Cardiopulmonary bypass time was 166 +/- 38 minutes, and average selective cerebral perfusion and lower body arrest time was 30 +/- 15 minutes.
  • [MeSH-minor] Acute Disease. Adult. Aged. Cardiopulmonary Bypass. Chronic Disease. Female. Humans. Male. Middle Aged. Vascular Surgical Procedures / methods

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  • (PMID = 16399301.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Huang X, Yu C, Jin C, Kobayashi M, Bowles CA, Wang F, McKeehan WL: Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis. Cancer Res; 2006 Feb 1;66(3):1481-90
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  • Fibroblast growth factor (FGF) signaling mediates cell-to-cell communication in development and organ homeostasis in adults.
  • Although FGFR1 is expressed by hepatic cell progenitors and adult nonparenchymal cells, ectopic expression is commonly observed in hepatoma cells.
  • Here, we determined whether ectopic FGFR1 is a cause or consequence of hepatocellular carcinoma by targeting a constitutively active human FGFR1 to mouse hepatocytes.
  • However, in diethylnitrosamine-treated mice, the chronic FGFR1 activity promoted an incidence of 44% adenomas at 4 months and 38% hepatocellular carcinoma at 8 months.
  • No adenoma or hepatocellular carcinoma was observed in diethylnitrosamine-treated wild-type (WT) livers at 4 or 8 months, respectively.
  • Isolated hepatoma cells from the transgenic tumors exhibited a growth advantage in culture.
  • Advanced hepatocellular carcinoma in the transgenic livers exhibited a reduced rate of necrosis.
  • In cooperation with an initiator, the persistent activity of ectopic FGFR1 in hepatocytes is a strong promoter of hepatocellular carcinoma by driving cell proliferation at early stages and promoting neoangiogenesis at late stages of progression.
  • [MeSH-major] Hepatocytes / metabolism. Liver Neoplasms, Experimental / metabolism. Receptor, Fibroblast Growth Factor, Type 1 / metabolism. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Animals. Carcinogens. Cell Growth Processes / physiology. Cell Transformation, Neoplastic / chemically induced. Cell Transformation, Neoplastic / metabolism. Cell Transformation, Neoplastic / pathology. DNA, Neoplasm / biosynthesis. Diethylnitrosamine. Hepatectomy. Humans. Liver / drug effects. Liver / physiology. Liver Regeneration / physiology. MAP Kinase Signaling System. Mice. Mice, Transgenic. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology

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  • (PMID = 16452204.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA 59971; United States / NIDDK NIH HHS / DK / R01 DK 35310; United States / NCI NIH HHS / CA / U01 CA 84296
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / DNA, Neoplasm; 0 / Vascular Endothelial Growth Factor A; 3IQ78TTX1A / Diethylnitrosamine; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1
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62. Pele LC, Thoree V, Mustafa F, He S, Tsaprouni L, Punchard NA, Thompson RP, Evans SM, Powell JJ: Low dietary calcium levels modulate mucosal caspase expression and increase disease activity in mice with dextran sulfate sodium induced colitis. J Nutr; 2007 Nov;137(11):2475-80
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  • [Title] Low dietary calcium levels modulate mucosal caspase expression and increase disease activity in mice with dextran sulfate sodium induced colitis.
  • BALB/c mice received a normal Ca (NCa) diet (0.5% Ca), a high Ca (HCa) diet (1.5% Ca), a low Ca (LCa) diet (0.05% Ca), or a very low Ca (VLCa) diet (0.009% Ca) for 3 wk.
  • Half of the mice in each group received DSS (1.5%) for 20 d in their drinking water, and disease activity was assessed.
  • DSS-induced disease activity was higher in mice fed low dietary Ca levels [P < 0.0001, VLCa and DSS vs. NCa and DSS (NCaDSS) and P < 0.005, LCa and DSS vs. NCaDSS], and mice from the VLCa group were moribund within 11 d of DSS administration.
  • Those in the HCa group did not differ greatly from controls.
  • [MeSH-minor] Animals. Dextran Sulfate. Disease Models, Animal. Female. Inflammation. Mice. Mice, Inbred BALB C

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  • (PMID = 17951488.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U105960399
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium, Dietary; 9042-14-2 / Dextran Sulfate; EC 3.4.22.- / Caspases; SY7Q814VUP / Calcium
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63. Abdo MR, Vullo D, Saada MC, Montero JL, Scozzafava A, Winum JY, Supuran CT: Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives. Bioorg Med Chem Lett; 2009 May 1;19(9):2440-3
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  • The compounds showed a weak hCA I activation profile, but were more efficient as hCA II and IX activators.
  • The 4-iodophenyl-substituted derivative behaved as a strong and isozyme selective hCA II activator, with an activation constant of 0.21muM.

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  • (PMID = 19345095.001).
  • [ISSN] 1464-3405
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Protein Isoforms; 0 / Recombinant Proteins; 0 / phenylsulfonylhydrazido l-histidine; 4QD397987E / Histidine; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
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64. Sinha R, Peters U, Cross AJ, Kulldorff M, Weissfeld JL, Pinsky PF, Rothman N, Hayes RB: Meat, meat cooking methods and preservation, and risk for colorectal adenoma. Cancer Res; 2005 Sep 1;65(17):8034-41
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  • [Title] Meat, meat cooking methods and preservation, and risk for colorectal adenoma.
  • Cooking meat at high temperatures produces heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs).
  • Meat intake may increase cancer risk as HCAs, PAHs, and N-nitroso compounds are carcinogenic in animal models.
  • We investigated meat, processed meat, HCAs, and the PAH benzo(a)pyrene and the risk of colorectal adenoma in 3,696 left-sided (descending and sigmoid colon and rectum) adenoma cases and 34,817 endoscopy-negative controls.
  • The questionnaire was linked to a previously developed database to determine exposure to HCAs and PAHs.
  • Intake of red meat, with known doneness/cooking methods, was associated with an increased risk of adenoma in the descending and sigmoid colon [odds ratio (OR), 1.26; 95% confidence interval (95% CI), 1.05-1.50 comparing extreme quintiles of intake] but not rectal adenoma.
  • Well-done red meat was associated with increased risk of colorectal adenoma (OR, 1.21; 95% CI, 1.06-1.37).
  • Increased risks for adenoma of the descending colon and sigmoid colon were observed for the two HCAs: 2-amino-3,8-dimethylimidazo[4,5]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5]pyridine (OR, 1.18; 95% CI, 1.01-1.38 and OR, 1.17, 95% CI, 1.01-1.35, respectively) as well as benzo(a)pyrene (OR, 1.18; 95% CI, 1.02-1.35).
  • Greater intake of bacon and sausage was associated with increased colorectal adenoma risk (OR, 1.14; 95% CI, 1.00-1.30); however, total intake of processed meat was not (OR, 1.04; 95% CI, 0.90-1.19).
  • Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma.
  • [MeSH-major] Adenoma / etiology. Colorectal Neoplasms / etiology. Cooking. Food Preservation. Meat

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  • (PMID = 16140978.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Imidazoles; 0 / Mutagens; 0 / Quinoxalines; 3417WMA06D / Benzo(a)pyrene; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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65. Osborne-Bossert C, Fitzgerald D, Speir A, St Onge J: Delivery of antegrade cerebral perfusion during descending aortic reconstruction: a case report. Perfusion; 2008 Mar;23(2):135-7
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  • Antegrade cerebral perfusion (ACP) has been demonstrated to be a safe and effective method of providing adequate protection to the brain during hypothermic circulatory arrest.
  • By improving oxygen delivery to the cerebral capillaries, users of this technique have reported fewer temporary neurological deficits in postoperative periods, even after prolonged periods of circulatory arrest.
  • Surgical correction of a descending aortic aneurysm can provide a challenge when the left subclavian artery is involved.
  • A period of hypothermic circulatory arrest is required to complete the proximal anastamosis of the graft.
  • A 54-year-old female presented with a computerized tomography (CT) scan of a descending aortic aneurysm, originating at the base of the left subclavian artery.

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  • (PMID = 18840584.001).
  • [ISSN] 0267-6591
  • [Journal-full-title] Perfusion
  • [ISO-abbreviation] Perfusion
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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66. Apostolakis EE, Baikoussis NG, Katsanos K, Karanikolas M: Postoperative peri-axillary seroma following axillary artery cannulation for surgical treatment of acute type A aortic dissection. J Cardiothorac Surg; 2010;5:43
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  • Right axillary artery cannulation confers significant advantages, because it provides antegrade arterial perfusion during cardiopulmonary bypass, and allows continuous antegrade cerebral perfusion during hypothermic circulatory arrest, thereby minimizing global cerebral ischemia.
  • We herein present the case of a 36-year-old Caucasian man with known Marfan syndrome and acute type A aortic dissection, who had direct right axillary artery cannulation for surgery of the ascending aorta.

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  • (PMID = 20500837.001).
  • [ISSN] 1749-8090
  • [Journal-full-title] Journal of cardiothoracic surgery
  • [ISO-abbreviation] J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2880968
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67. Kouchoukos NT, Masetti P, Mauney MC, Murphy MC, Castner CF: One-stage repair of extensive chronic aortic dissection using the arch-first technique and bilateral anterior thoracotomy. Ann Thorac Surg; 2008 Nov;86(5):1502-9
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  • METHODS: Fifty-one patients with chronic expanding thoracic aortic dissections (48 type A, 3 type B with proximal extension) were treated with a single procedure using a bilateral anterior thoracotomy, hypothermic circulatory arrest, and reperfusion of the arch vessels first to minimize brain ischemia.
  • Forty-six patients had previous operations: for acute type A aortic dissection (n = 36), aortic valve disease (n = 6), or coronary artery disease (n = 4).
  • CONCLUSIONS: The technique is a safe and suitable alternative to the two-stage (elephant trunk technique) and hybrid procedures for treatment of chronic dissection with aneurysm of the thoracic aorta.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chronic Disease. Humans. Middle Aged. Recurrence. Reoperation. Survival Rate

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  • [CommentIn] Ann Thorac Surg. 2008 Nov;86(5):1509 [19049740.001]
  • (PMID = 19049739.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
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68. Ambrosi DJ, Tanasijevic B, Kaur A, Obergfell C, O'Neill RJ, Krueger W, Rasmussen TP: Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells. Stem Cells; 2007 May;25(5):1104-13
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  • [Title] Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells.
  • The resulting hybrids are pluripotent as judged by developmental assays, but detailed analyses of the underlying molecular-genetic control of reprogrammed transcription in such hybrids are required to better understand fusion-mediated reprogramming.
  • Comprehensive analysis of the mouse embryonic fibroblast/ESC hybrid transcriptome revealed global patterns of gene expression reminiscent of ESCs.
  • However, combined analysis of variance and hierarchical clustering analyses revealed at least seven distinct classes of differentially regulated genes in comparisons of hybrids, ESCs, and somatic cells.
  • Somatic/ESC hybrid cell lines resemble their pre-fusion ESC partners in terms of behavior in culture and pluripotency.
  • [MeSH-major] Cellular Reprogramming / genetics. Chimera / genetics. Embryonic Stem Cells / metabolism. Genome
  • [MeSH-minor] Alleles. Animals. Base Sequence. Cell Line. Chromosomes, Mammalian / genetics. Cluster Analysis. DNA Mutational Analysis. Gene Expression Profiling. Gene Expression Regulation, Developmental. Karyotyping. Mice. Molecular Sequence Data. Pluripotent Stem Cells / metabolism. Transcription, Genetic

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  • (PMID = 17272499.001).
  • [ISSN] 1066-5099
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01AG23687
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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69. Baraki H, Hagl C, Khaladj N, Kallenbach K, Weidemann J, Haverich A, Karck M: The frozen elephant trunk technique for treatment of thoracic aortic aneurysms. Ann Thorac Surg; 2007 Feb;83(2):S819-23; discussion S824-31
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  • BACKGROUND: The frozen elephant trunk technique allows for single-stage repair of combined aortic arch and descending aortic aneurysms using a hybrid prosthesis with a stented and a nonstented end.
  • The stented end of the hybrid prosthesis was placed through the opened aortic arch under fluoroscopic control using hypothermic circulatory arrest and selective antegrade cerebral perfusion.
  • In 1 patient, the descending aorta was perforated owing to misplacement of the stented end of the hybrid prosthesis.

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  • (PMID = 17257934.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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70. Horiuchi S, Kumai R, Tokunaga Y, Tokura Y: Proton dynamics and room-temperature ferroelectricity in anilate salts with a proton sponge. J Am Chem Soc; 2008 Oct 8;130(40):13382-91
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  • Dielectric measurements revealed phase transitions at T(c) = 334 and 172 K for bromanilate (Hba(-)) and chloranilate (Hca(-)) salts, respectively.

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  • (PMID = 18781747.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Xie C, Mace J, Dinno MA, Li YQ, Tang W, Newton RJ, Gemperline PJ: Identification of single bacterial cells in aqueous solution using confocal laser tweezers Raman spectroscopy. Anal Chem; 2005 Jul 15;77(14):4390-7
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  • [Title] Identification of single bacterial cells in aqueous solution using confocal laser tweezers Raman spectroscopy.
  • We report on a rapid method for reagentless identification and discrimination of single bacterial cells in aqueous solutions using a combination of laser tweezers and confocal Raman spectroscopy (LTRS).
  • The optical trapping enables capturing of individual bacteria in aqueous solution in the focus of the laser beam and levitating the captured cell well off the cover plate, thus maximizing the excitation and collection of Raman scattering from the cell and minimizing the unwanted background from the cover plate and environment.
  • Raman spectral patterns excited by a near-infrared laser beam provide intrinsic molecular information for reagentless analysis of the optically isolated bacterium.
  • We show that synchronized bacterial cells can be well-discriminated among the six species using principal component analyses (PCA).
  • Unsynchronized bacterial cells that are cultured at stationary phases can also be well-discriminated by the PCA, as well as by a hierarchical cluster analysis (HCA) of their Raman spectra.
  • We also show that unsynchronized bacteria selected from random growth phases can be classified with the help of a generalized discriminant analysis (GDA).
  • These findings demonstrate that the LTRS may find valuable applications in rapid sensing of microbial cells in diverse aqueous media.
  • [MeSH-major] Bacteria / cytology. Optical Tweezers. Spectrum Analysis, Raman / instrumentation. Spectrum Analysis, Raman / methods

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  • (PMID = 16013851.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Solutions
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72. Puccetti L, Fasolis G, Cecchi A, Winum JY, Gamberi A, Montero JL, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Bioorg Med Chem Lett; 2005 May 2;15(9):2359-64
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  • A series of such aromatic sulfonamides incorporating thioureido-sulfanilyl moieties has been prepared and investigated for its interaction with the catalytic domain of the human isozyme hCA IX.
  • Due to the highest expression of CA IX in clear renal cell carcinoma and its chemo/radioresistance, our efforts are first of all directed to generate effective therapeutic strategies for the cure of this malignancy.

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  • (PMID = 15837325.001).
  • [ISSN] 0960-894X
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carbonic Anhydrase Inhibitors; 0 / Sulfonamides; 8W8T17847W / Urea; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
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73. Réti A, Barna G, Pap E, Adleff V, L Komlósi V, Jeney A, Kralovánszky J, Budai B: Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells. Pathol Oncol Res; 2009 Sep;15(3):335-44
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  • [Title] Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells.
  • The antiproliferative effect of 5-fluorouracil (5-FU) in the presence of low dose non-steroidal anti-inflammatory drugs (NSAIDs) on high cyclooxygenase-2 (COX-2)-expressing HCA-7 and low COX-2-expressing HT-29 colon carcinoma cell lines was investigated.
  • Pharmacogenetic parameters were studied to characterize the 5-FU sensitivity of the two cell lines.
  • Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms were determined by PCR analysis.
  • Cell proliferation was measured by SRB assay, cell cycle distribution and apoptosis by FACS analysis.
  • The HT-29 cell line was found to be homozygous for TS 2R and 1494ins6 and T homozygous for MTHFR 677 polymorphisms predicting high 5-FU sensitivity (IC(50): 10 microM).
  • TS 3R homozygosity, TS 1496del6 and MTHFR 677CT heterozygosity may explain the modest 5-FU sensitivity (IC(50): 1.1 mM) of the HCA-7 cell line.
  • Indomethacin and NS-398 (10 microM and 1.77 microM, respectively) reduced the PGE(2) level in HCA-7 cells (>90%).
  • Low concentrations of NSAIDs without antiproliferative potency increased the S-phase arrest and enhanced the cytotoxic action of 5-FU only in HCA-7 cells after 48-hours treatment.
  • The presented data suggested that the enhancement of 5-FU cytotoxicity by indomethacin or NS-398 applied in low dose is related to the potency of NSAIDs to modulate the cell-cycle distribution and the apoptosis; however, it seems that this effect might be dependent on cell phenotype, namely on the COX-2 expression.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Cell Proliferation / drug effects. Cyclooxygenase 2 / metabolism. Cyclooxygenase Inhibitors / pharmacology. Fluorouracil / pharmacology
  • [MeSH-minor] Apoptosis / drug effects. Blotting, Western. Cell Line, Tumor. Cell Separation. Enzyme-Linked Immunosorbent Assay. Flow Cytometry. HT29 Cells. Humans. Indomethacin / pharmacology. Methylenetetrahydrofolate Dehydrogenase (NADP) / genetics. Microscopy, Fluorescence. Nitrobenzenes / pharmacology. Polymorphism, Genetic. Reverse Transcriptase Polymerase Chain Reaction. Sulfonamides / pharmacology. Thymidylate Synthase / genetics

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  • (PMID = 19048402.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cyclooxygenase Inhibitors; 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.5.1.5 / Methylenetetrahydrofolate Dehydrogenase (NADP); EC 2.1.1.45 / Thymidylate Synthase; U3P01618RT / Fluorouracil; XXE1CET956 / Indomethacin
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74. Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT: Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors. J Med Chem; 2005 Dec 1;48(24):7860-6
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  • A lately discovered carbonic anhydrase (hCA, EC 4.2.1.1), the mitochondrial hCA VB, was cloned, expressed, and purified.
  • Kinetic parameters proved it to be 3.37 times more effective than hCA VA as a catalyst for the physiological reaction, with kcat = 9.5 x 10(5) s(-1) and kcat/K(M) = 9.8 x 10(7) M(-1) s(-1), being second only to hCA II among the 16 isoforms presently known in humans.
  • We investigated the inhibition of hCA VB with a library of sulfonamides/sulfamates, some of which are clinically used compounds.
  • Benzenesulfonamides were ineffective inhibitors, whereas derivatives bearing 4-amino, 4-hydrazino, 4-methyl, 4-carboxy moieties or halogenated sulfanilamides were more effective (Ki's of 1.56-4.3 microM).
  • Among the 10 clinically used compounds, acetazolamide, benzolamide, topiramate, and indisulam showed effective inhibitory activity (Ki's of 18-62 nM).
  • Three compounds showed better activity against hCA VB over hCA II, among which were sulpiride and ethoxzolamide, which were 2 times more effective inhibitors of the mitochondrial over the cytosolic isozyme. hCA VB is a druggable target and some of its inhibitors may lead to the development of novel antiobesity therapies.

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  • (PMID = 16302824.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; 0 / Sulfonamides; 0 / Sulfonic Acids; 9NFU33906Q / sulfamic acid; EC 4.2.1.- / Carbonic Anhydrase V
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75. National Toxicology Program: NTP toxicology and carcinogenesis studies of 5-(Hydroxymethyl)-2-furfural (CAS No. 67-47-0) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Jun;(554):7-13, 15-9, 21-31 passim
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  • Heart weights of 1,500 mg/kg females were significantly greater than those of the vehicle controls.
  • The incidences of hepatocellular adenoma were significantly increased in 188 and 375 mg/kg females.
  • GENETIC TOXICOLOGY 5-(Hydroxymethyl)-2-furfural was tested in two independent bacterial mutagenicity assays.
  • There was some evidence of carcinogenic activity of 5-(hydroxymethyl)-2-furfural in female B6C3F1 mice based on increased incidences of hepatocellular adenoma in the 188 and 375 mg/kg groups.

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  • (PMID = 20725154.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 70ETD81LF0 / 5-hydroxymethylfurfural; DJ1HGI319P / Furaldehyde
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81. Weigelt B, Horlings HM, Kreike B, Hayes MM, Hauptmann M, Wessels LF, de Jong D, Van de Vijver MJ, Van't Veer LJ, Peterse JL: Refinement of breast cancer classification by molecular characterization of histological special types. J Pathol; 2008 Oct;216(2):141-50
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  • We aimed to refine the breast cancer classification systems by analysing a series of 11 histological special types [invasive lobular carcinoma (ILC), tubular, mucinous A, mucinous B, neuroendocrine, apocrine, IDC with osteoclastic giant cells, micropapillary, adenoid cystic, metaplastic, and medullary carcinoma] using immunohistochemistry and genome-wide gene expression profiling.
  • Hierarchical clustering analysis confirmed that some histological special types constitute discrete entities, such as micropapillary carcinoma, but also revealed that others, including tubular and lobular carcinoma, are very similar at the transcriptome level.
  • Our analysis also revealed that some special types associated with a good prognosis, such as medullary and adenoid cystic carcinomas, display a poor prognosis basal-like transcriptome, providing strong circumstantial evidence that basal-like cancers constitute a heterogeneous group.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cluster Analysis. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Oligonucleotide Array Sequence Analysis. Signal Transduction / genetics. Statistics, Nonparametric


82. Coban TA, Beydemir S, Gülçin I, Ekinci D: Morphine inhibits erythrocyte carbonic anhydrase in vitro and in vivo. Biol Pharm Bull; 2007 Dec;30(12):2257-61
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  • Human erythrocyte isoenzymes, HCA-I and HCA-II, were purified by Sepharose-4B affinity chromatography column with a yield of 66.95 and 62.82%, a specific activity of 3892.3 and 11663.2 EU/mg proteins with 745.1 and 2232.6-fold purification of each isoenzyme, respectively.
  • In vitro inhibition of erythrocyte HCA-I and HCA-II by morphine using the CO(2)-hydratase enzyme gave IC(50) values 4.50 x 10(-5) M (r(2): 0.954) and 9.23 x 10(-5) M (r(2): 0.996), respectively.

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  • (PMID = 18057708.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Narcotics; 76I7G6D29C / Morphine; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II
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83. Smith J, Roberts R, Fahy S: Use of study days to develop the healthcare assistant role. Nurs Times; 2006 Jul 25-31;102(30):34-5
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  • The Department of Health's strategies to combat staff shortages and an ageing workforce have now turned their focus to the delivery of patient care by HCAs.
  • This article describes how a trust redesigned the role of HCAs and implemented a study day in order to enhance both theoretical knowledge and clinical practice for this role.

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  • (PMID = 16903305.001).
  • [ISSN] 0954-7762
  • [Journal-full-title] Nursing times
  • [ISO-abbreviation] Nurs Times
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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84. Neugebauer U, Schmid U, Baumann K, Ziebuhr W, Kozitskaya S, Holzgrabe U, Schmitt M, Popp J: The influence of fluoroquinolone drugs on the bacterial growth of S. epidermidis utilizing the unique potential of vibrational spectroscopy. J Phys Chem A; 2007 Apr 19;111(15):2898-906
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  • [Title] The influence of fluoroquinolone drugs on the bacterial growth of S. epidermidis utilizing the unique potential of vibrational spectroscopy.
  • In this work, vibrational spectroscopy is used to shed more light on the as-yet elusive interaction of gyrase inhibitors of the fluoroquinolone type with their biological target inside the Gram-positive bacterium Staphylococcus epidermidis by investigating whole-cell changes that occur as a result of the presence of the drug moxifloxacin.
  • The spectral changes caused by the action of the drug were analyzed with the help of statistical methods, such as hierarchical cluster analysis (HCA), principal component analysis (PCA), and Fisher's linear discriminant analysis (LDA) combined with variable selection.
  • The wavenumbers mostly affected by the action of the drug could be assigned to protein and DNA moieties, supporting the proposed mechanisms of a tertiary complex of the fluoroquinolone, the enzyme gyrase, and DNA.
  • [MeSH-minor] Aza Compounds / pharmacology. Cluster Analysis. DNA / metabolism. DNA Gyrase / metabolism. Models, Chemical. Models, Statistical. Principal Component Analysis. Quinolines / pharmacology. Spectrophotometry, Infrared. Spectrum Analysis, Raman. Time Factors. Ultraviolet Rays

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  • (PMID = 17385845.001).
  • [ISSN] 1089-5639
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Aza Compounds; 0 / Fluoroquinolones; 0 / Quinolines; 9007-49-2 / DNA; EC 5.99.1.3 / DNA Gyrase; U188XYD42P / moxifloxacin
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85. Neugebauer U, Schmid U, Baumann K, Ziebuhr W, Kozitskaya S, Deckert V, Schmitt M, Popp J: Towards a detailed understanding of bacterial metabolism--spectroscopic characterization of Staphylococcus epidermidis. Chemphyschem; 2007 Jan 8;8(1):124-37
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  • To fight disease and growing resistance, research interest is focused on understanding bacterial metabolism.
  • IR absorption spectroscopy reflects the overall chemical composition of the cells, with major focus on the protein vibrations.
  • Smaller sample volumes-down to a single cell-are sufficient to probe the overall chemical composition by means of micro-Raman spectroscopy.
  • In combination with statistical evaluation methods [hierarchical cluster analysis (HCA), principal component analysis (PCA), linear discriminant analysis (LDA)], the protein and nucleic-acid components that change during the different bacterial growth phases can be identified from the in vivo vibrational spectra.
  • Furthermore, tip-enhanced Raman spectroscopy (TERS) provides insight into the surface structures and follows the dynamics of the polysaccharide and peptide components on the bacterial cells with a spatial resolution below the diffraction limit.
  • [MeSH-major] Spectrophotometry, Infrared / methods. Spectrum Analysis, Raman / methods. Staphylococcus epidermidis / chemistry. Staphylococcus epidermidis / metabolism

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  • (PMID = 17146809.001).
  • [ISSN] 1439-4235
  • [Journal-full-title] Chemphyschem : a European journal of chemical physics and physical chemistry
  • [ISO-abbreviation] Chemphyschem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Nucleic Acids
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86. Correnti M, Cavazza ME, Herrera O, Rodríguez A: Presence of human papillomavirus infection determined by hybrid capture assay in cervical lesions in a Venezuelan population. Invest Clin; 2010 Mar;51(1):27-35
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  • [Title] Presence of human papillomavirus infection determined by hybrid capture assay in cervical lesions in a Venezuelan population.
  • The aim of this study was to establish the presence of HPV infection in cervical lesions in a Venezuelan population, by Hybrid Capture Assay II (HCA II), and its association with cytological diagnosis.
  • HPV infection was determined using HCA II.
  • The cytological diagnosis of the smears showed LSIL in 1120/1483 samples (75.5%), HSIL in 354/1483 (23.9%) and ASC-US, in 9/1483 (0.6%).
  • The positivity of HPV DNA detected by HCA II was 54.6% (811/1483).
  • Our study showed a high presence of cervical infection by human papillomavirus of a high risk genotype.
  • [MeSH-major] Papillomavirus Infections / diagnosis. Papillomavirus Infections / virology. Uterine Cervical Neoplasms / virology

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  • (PMID = 20815154.001).
  • [ISSN] 0535-5133
  • [Journal-full-title] Investigación clínica
  • [ISO-abbreviation] Invest Clin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Venezuela
  • [Chemical-registry-number] 0 / DNA Probes, HPV
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87. Wilkinson BL, Bornaghi LF, Houston TA, Innocenti A, Supuran CT, Poulsen SA: A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". J Med Chem; 2006 Nov 2;49(22):6539-48
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  • These compounds were assessed for their ability to inhibit three human CA isozymes in vitro: cytosolic hCA I and hCA II and transmembrane, tumor-associated hCA IX.
  • The qualitative structure-activity for all derivatives demonstrated that the stereochemical diversity present within the carbohydrate tails effectively interrogated the CA active site topology, to generate several inhibitors that were potent and selective toward hCA IX, an important outcome in the quest for potential cancer therapy applications based on CA inhibition.

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  • (PMID = 17064072.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzene Derivatives; 0 / Carbonic Anhydrase Inhibitors; 0 / Indicators and Reagents; 0 / Isoenzymes; 0 / Sulfonamides; 142M471B3J / Carbon Dioxide
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88. Xu L, Han X, Qi Y, Xu Y, Yin L, Peng J, Liu K, Sun C: Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. Anal Chim Acta; 2009 Feb 2;633(1):136-48
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  • [Title] Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
  • A simple and reliable high-performance liquid chromatography (HPLC) coupled with photodiode array detector (DAD) method was developed both for fingerprint analysis (FA) and quantitative determination.
  • In quantitative analysis, linear regressions, limit of detection (LOD) and quantification (LOQ), intra-day and inter-day precisions, recovery, repeatability and stability were all tested and good results were obtained to simultaneously determine the 15 marker compounds, namely chlorogenic acid, rhaponticin, 6,7-dimethoxycoumarin, naringin, hesperidin, neohesperidin, baicalin, wogonoside, baicalein, wogonin, chrysin, honokiol, magnolol, emodin, and chrysophanol in the herbal drugs.
  • In fingerprint analysis, 34 peaks were selected as the characteristic peaks to evaluate the similarities of different samples collected from different pharmaceutical companies in China according to the State Food and Drug Administration (SFDA) requirements, and two kinds of data, relative retention time (RRT) and relative peak area (RPA) were used to identify the common peaks in 15 samples for investigation.
  • Furthermore, hierarchical cluster analysis (HCA) was also performed to evaluate the variation of the herbal drugs.
  • [MeSH-major] Chromatography, High Pressure Liquid / methods. Drugs, Chinese Herbal / analysis

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  • (PMID = 19110127.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Solvents
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89. Budayova-Spano M, Fisher SZ, Dauvergne MT, Agbandje-McKenna M, Silverman DN, Myles DA, McKenna R: Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II. Acta Crystallogr Sect F Struct Biol Cryst Commun; 2006 Jan 1;62(Pt 1):6-9
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  • [Title] Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II.
  • Human carbonic anhydrase II (HCA II) is a zinc metalloenzyme that catalyzes the reversible hydration and dehydration of carbon dioxide and bicarbonate, respectively.
  • The rate-limiting step in catalysis is the intramolecular transfer of a proton between the zinc-bound solvent (H2O/OH-) and the proton-shuttling residue His64.
  • Despite the availability of high-resolution (approximately 1.0 A) X-ray crystal structures of HCA II, there is currently no definitive information available on the positions and orientations of the H atoms of the solvent network or active-site amino acids and their ionization states.
  • In preparation for neutron diffraction studies to elucidate this hydrogen-bonding network, perdeuterated HCA II has been expressed, purified, crystallized and its X-ray structure determined to 1.5 A resolution.
  • The refined structure is highly isomorphous with hydrogenated HCA II, especially with regard to the active-site architecture and solvent network.

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  • (PMID = 16511248.001).
  • [ISSN] 1744-3091
  • [Journal-full-title] Acta crystallographica. Section F, Structural biology and crystallization communications
  • [ISO-abbreviation] Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
  • [Language] ENG
  • [Databank-accession-numbers] PDB/ 2AX2/ R2AX2SF
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM025154; United States / NIGMS NIH HHS / GM / GM25154
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Recombinant Proteins; AR09D82C7G / Deuterium; EC 4.2.1.- / Carbonic Anhydrase II
  • [Other-IDs] NLM/ PMC2150928
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90. Jia L, Wang S, Cao J, Zhou H, Wei W, Zhang J: siRNA targeted against matrix metalloproteinase 11 inhibits the metastatic capability of murine hepatocarcinoma cell Hca-F to lymph nodes. Int J Biochem Cell Biol; 2007;39(11):2049-62
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  • [Title] siRNA targeted against matrix metalloproteinase 11 inhibits the metastatic capability of murine hepatocarcinoma cell Hca-F to lymph nodes.
  • MMP-11 is strongly expressed in tumor cells and stromal fibroblasts located in the immediate vicinity of tumor.
  • This study investigated the possible role of MMP-11 expression in mouse hepatocarcinoma cell line Hca-F with highly lymphatic metastasis potential by RNA interference (RNAi) approach.
  • The results showed that a small interfering RNA (siRNA) targeted against MMP-11 significantly impeded Hca-F cells proliferation and colony formation in soft agar, as well as resulted in Hca-F cell apoptosis.
  • This reduction of MMP-11 expression also led to the decreased migration and adhesion of Hca-F cells dramatically both in vitro and in vivo.
  • Furthermore, in vivo metastasis assay indicated that down-regulation of MMP-11 expression in Hca-F cells attenuated the metastatic potential of Hca-F cells to peripheral lymph nodes.
  • [MeSH-major] Carcinoma, Hepatocellular / enzymology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / enzymology. Liver Neoplasms / pathology. Lymph Nodes / pathology. Matrix Metalloproteinase Inhibitors. RNA, Small Interfering / pharmacology
  • [MeSH-minor] Animals. Apoptosis / drug effects. Cell Adhesion / drug effects. Cell Line, Tumor. Cell Movement / drug effects. Cell Proliferation / drug effects. Gene Expression Regulation, Neoplastic / drug effects. Gene Silencing. Immunohistochemistry. Matrix Metalloproteinase 11 / genetics. Matrix Metalloproteinase 11 / metabolism. Mice. Neoplasm Metastasis. RNA, Messenger / genetics. RNA, Messenger / metabolism

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  • (PMID = 17627864.001).
  • [ISSN] 1357-2725
  • [Journal-full-title] The international journal of biochemistry & cell biology
  • [ISO-abbreviation] Int. J. Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Matrix Metalloproteinase Inhibitors; 0 / RNA, Messenger; 0 / RNA, Small Interfering; EC 3.4.24.- / Matrix Metalloproteinase 11
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91. Skerman HM, Yates PM, Battistutta D: Multivariate methods to identify cancer-related symptom clusters. Res Nurs Health; 2009 Jun;32(3):345-60
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  • Conceptually, common factor analysis (FA) and hierarchical cluster analysis (HCA) are appropriate for symptom cluster identification, not principal component analysis.
  • As a basis for new directions in symptom management, FA methods are more appropriate than HCA.
  • [MeSH-major] Cluster Analysis. Cross-Sectional Studies. Data Interpretation, Statistical. Multivariate Analysis. Neoplasms / complications. Nursing Research / methods
  • [MeSH-minor] Decision Support Techniques. Factor Analysis, Statistical. Guidelines as Topic. Humans. Likelihood Functions. Nursing Assessment. Principal Component Analysis. Regression Analysis. Reproducibility of Results. Research Design

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc.
  • (PMID = 19274688.001).
  • [ISSN] 1098-240X
  • [Journal-full-title] Research in nursing & health
  • [ISO-abbreviation] Res Nurs Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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92. Kim YS, Eun H, Cho HS, Kim KS, Watanabe E, Baba K, Katase T: The characterization of PCDDs, PCDFs and coplanar PCBs during the past 50 years in Gwangyang Bay, South Korea. J Hazard Mater; 2008 Jun 15;154(1-3):756-65
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  • The dioxin in the sediment samples was found to come from a mixture of the impurities of pentachlorophenol (PCP), chloronitrofen (CNP) and combustion based on the result of hierarchical cluster analysis (HCA).
  • According to principal component analysis (PCA) related to the Kow values for the congener-specific composition of co-PCBs in the sediment core, the Kanechlor (KC)-500 and the atmospheric deposition were identified as the possible sources.
  • [MeSH-major] Benzofurans / analysis. Geologic Sediments / analysis. Polychlorinated Biphenyls / analysis. Tetrachlorodibenzodioxin / analogs & derivatives. Water Pollutants, Chemical / analysis

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  • (PMID = 18063300.001).
  • [ISSN] 0304-3894
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Benzofurans; 0 / Water Pollutants, Chemical; 0 / chlorinated dibenzofurans; 0 / polychlorodibenzo-4-dioxin; DFC2HB4I0K / Polychlorinated Biphenyls; DO80M48B6O / Tetrachlorodibenzodioxin
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93. Lu LS, Wu CC, Hung LM, Chiang MT, Lin CT, Lin CW, Su MJ: Apocynin alleviated hepatic oxidative burden and reduced liver injury in hypercholesterolaemia. Liver Int; 2007 May;27(4):529-37
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  • [Title] Apocynin alleviated hepatic oxidative burden and reduced liver injury in hypercholesterolaemia.
  • BACKGROUND: This study addressed the effects of apocynin, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, on hepatic oxidative burden and liver injury during diet-induced hypercholesterolaemia.
  • The high-cholesterol diet (HC) significantly increased the serum level of cholesterol and hepatic cholesterol ester deposition, and these parameters were similar between the HC and high-cholesterol diet plus apocynin (HCA) groups.
  • The HC group showed abnormal liver function tests [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (Alk-P)] as well as increased Evans blue extravasation and macrophages infiltration.
  • Biochemical analysis of redox status including thiobarbituric acid reactive substances, reduced glutathione, and oxidized glutathione also confirmed the phenomenon.
  • CONCLUSIONS: We concluded that apocynin suppressed NADPH oxidase activation and subsequent liver injuries owing to high-cholesterol intake in rats.
  • [MeSH-major] Acetophenones / pharmacology. Hypercholesterolemia / complications. Hypercholesterolemia / drug therapy. Liver Diseases / prevention & control. Oxidative Stress / drug effects
  • [MeSH-minor] Animals. Antioxidants. Cholesterol / administration & dosage. Cholesterol / blood. Hepatocytes. Inflammation / prevention & control. Liver Function Tests. Male. NADPH Oxidase. Oxidation-Reduction. Rats. Rats, Wistar

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  • (PMID = 17403193.001).
  • [ISSN] 1478-3223
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Acetophenones; 0 / Antioxidants; 97C5T2UQ7J / Cholesterol; B6J7B9UDTR / acetovanillone; EC 1.6.3.1 / NADPH Oxidase
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94. Bosley S, Dale J: Healthcare assistants in general practice: practical and conceptual issues of skill-mix change. Br J Gen Pract; 2008 Feb;58(547):118-24
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  • The emergence of healthcare assistants (HCAs) in general practice raises questions about roles and responsibilities, patients' acceptance, cost-effectiveness, patient safety and delegation, training and competence, workforce development, and professional identity.
  • There has been minimal research into the role of HCAs and their experiences, as well as those of other staff working with HCAs in general practice.
  • Drawing on the limited research in general practice, the challenges and benefits of developing the HCA role in general practice are discussed.
  • It is concluded that HCAs can make an increasingly useful contribution to the skill mix in general practice, but that more research and evaluation are needed to inform their training and development within the general practice team.
  • [MeSH-minor] Cost-Benefit Analysis. Humans. Safety Management

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  • (PMID = 18307856.001).
  • [ISSN] 0960-1643
  • [Journal-full-title] The British journal of general practice : the journal of the Royal College of General Practitioners
  • [ISO-abbreviation] Br J Gen Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2233962
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95. Zou P, Hong Y, Koh HL: Chemical fingerprinting of Isatis indigotica root by RP-HPLC and hierarchical clustering analysis. J Pharm Biomed Anal; 2005 Jul 1;38(3):514-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemical fingerprinting of Isatis indigotica root by RP-HPLC and hierarchical clustering analysis.
  • Hierarchical clustering analysis gave similar results as the visual comparison.
  • This is the first report of hierarchical clustering analysis of I. indigotica root.
  • [MeSH-major] Chromatography, High Pressure Liquid / methods. Cluster Analysis. Isatis / chemistry. Plant Extracts / analysis. Plant Roots / chemistry
  • [MeSH-minor] Drugs, Chinese Herbal / analysis. Drugs, Chinese Herbal / chemistry. Indigo Carmine. Indoles / analysis. Molecular Structure. Powders. Reference Standards. Reproducibility of Results. Technology, Pharmaceutical / methods

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  • (PMID = 15925253.001).
  • [ISSN] 0731-7085
  • [Journal-full-title] Journal of pharmaceutical and biomedical analysis
  • [ISO-abbreviation] J Pharm Biomed Anal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Indoles; 0 / Plant Extracts; 0 / Powders; D3741U8K7L / Indigo Carmine; V86L8P74GI / indirubin
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96. Givehchian M, Beschorner R, Ehmann C, Frauenlob L, Morgalla M, Hashemi B, Ziemer G, Scheule AM: Neuroprotective effects of erythropoietin during deep hypothermic circulatory arrest. Eur J Cardiothorac Surg; 2010 Mar;37(3):662-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroprotective effects of erythropoietin during deep hypothermic circulatory arrest.
  • Using a surviving porcine model, this study evaluates whether systemic treatment with erythropoietin induces brain protection in deep hypothermic circulatory arrest (DHCA).
  • CONCLUSION: These results suggest some beneficial neuroprotective effects of erythropoietin in this model of global brain ischaemia induced by 1h of hypothermic circulatory arrest.
  • [MeSH-major] Erythropoietin / therapeutic use. Heart Arrest, Induced / adverse effects. Hypoxia-Ischemia, Brain / prevention & control. Neuroprotective Agents / therapeutic use
  • [MeSH-minor] Animals. Brain / metabolism. Disease Models, Animal. Drug Evaluation, Preclinical. Hemodynamics / physiology. Hypothermia, Induced / adverse effects. Intracranial Pressure / drug effects. Oxygen Consumption / drug effects. Perioperative Care / methods. Random Allocation. Recombinant Proteins. Sus scrofa

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  • [Copyright] Copyright (c) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
  • (PMID = 19766506.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neuroprotective Agents; 0 / Recombinant Proteins; 11096-26-7 / Erythropoietin
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97. Brzozowski Z, Sławiński J, Saczewski F, Innocenti A, Supuran CT: Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. Eur J Med Chem; 2010 Jun;45(6):2396-404
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Against the human isozymes hCA I, the new compounds showed inhibition constants in the range of 0.078-11.7 microM, against hCA II in the range of 9.9-140 nM, against hCA IX in the range of 4.6-313 nM, against hCA XII in the range of 3.4-21.6 nM, and against hCA XIV in the range of 50.9-160 nM, respectively.
  • Compounds 4, 6, 7, 9, 11-14, 19, 20, 22-24, 26, 27, 31 and 32 showed excellent hCA IX inhibitory efficacy, with inhibition constants of 4.6-12.0 nM, being much more effective as compared to the clinically used sulfonamides AAZ, MZA, EZA, DCP and IND.
  • 4-[N'-(6-chloro-7-cyano-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide (31) is the prominent of the compounds due to its remarkable inhibitory activity toward hCA I (KIs=0.078 microM), hCA IX (KIs=7.2 nM) and hCA XII (KIs=3.4 nM).

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20202722.001).
  • [ISSN] 1768-3254
  • [Journal-full-title] European journal of medicinal chemistry
  • [ISO-abbreviation] Eur J Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; 0 / Sulfonamides; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases; EC 4.2.1.1 / carbonic anhydrase XII; EC 4.2.1.1 / carbonic anhydrase XIV
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98. Wilkinson BL, Bornaghi LF, Houston TA, Innocenti A, Vullo D, Supuran CT, Poulsen SA: Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg Med Chem Lett; 2007 Feb 15;17(4):987-92
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  • A library of glycoconjugate benzenesulfonamides that contain diverse carbohydrate-triazole tails were investigated for their ability to inhibit the enzymatic activity of the three human transmembrane carbonic anhydrase (CA) isozymes hCA IX, hCA XII and hCA XIV.
  • These isozymes have their CA domains located extracellularly, unlike the physiologically dominant hCA II, and are of immense current interest as druggable targets.
  • Elevated expression of isozymes IX and XII is a marker for a broad spectrum of hypoxic tumors-this physiology may facilitate a novel approach to discriminate between healthy cells and cancerous cells.
  • The most potent hCA IX inhibitor was the glucuronic acid derivative 20 (K(i)=23nM).
  • This compound was uniquely hCA IX selective cf. all other isozymes (16.4-, 16.8- and 4.6-fold selective against hCA II, XII, and XIV, respectively).
  • At hCA XII there were many inhibitors with K(i)s<10nM that also demonstrated excellent selectivity (up to 344-fold) against other isozymes.
  • Potent hCA XIV inhibitors were also identified, several with K(i)s approximately 10nM, however no hCA XIV-selective derivatives were evidenced from this library.

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  • (PMID = 17157501.001).
  • [ISSN] 0960-894X
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Glycoconjugates; 0 / Isoenzymes; 0 / Recombinant Proteins; 0 / Sulfonamides; I6G9Y0J1OJ / Phenolsulfonphthalein
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99. Wong V, Wang DY, Warren K, Kulkarni S, Boerner S, Done SJ, Leong WL: The effects of timing of fine needle aspiration biopsies on gene expression profiles in breast cancers. BMC Cancer; 2008;8:277
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  • BACKGROUND: DNA microarray analysis has great potential to become an important clinical tool to individualize prognostication and treatment for breast cancer patients.
  • Our study examines one variable that is often overlooked, the timing of tissue acquisition, which may have a significant impact on the outcomes of DNA microarray analyses especially in studies that compare microarray data based on biospecimens taken in vivo and ex vivo.
  • RESULTS: Using hierarchical clustering analysis, 12 genes were found to be differentially expressed between the FNABs taken before and after surgical removal.
  • CONCLUSION: Our study demonstrated that the timing of fine needle aspiration biopsies can be a confounding factor in microarray data analyses in breast cancer.
  • [MeSH-minor] Adult. Biomarkers, Tumor. Breast / metabolism. Breast / pathology. Cell Hypoxia. Cluster Analysis. Female. Genes, fos. Humans. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction. Time Factors

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  • (PMID = 18826606.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2567989
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100. Suh YH, Kim Y, Bang JH, Choi KS, Lee JW, Kim WH, Oh TJ, An S, Jung MH: Analysis of gene expression profiles in insulin-sensitive tissues from pre-diabetic and diabetic Zucker diabetic fatty rats. J Mol Endocrinol; 2005 Apr;34(2):299-315
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of gene expression profiles in insulin-sensitive tissues from pre-diabetic and diabetic Zucker diabetic fatty rats.
  • Insulin resistance occurs early in the disease process, preceding the development of type 2 diabetes.
  • Therefore, the identification of molecules that contribute to insulin resistance and leading up to type 2 diabetes is important to elucidate the molecular pathogenesis of the disease.
  • To this end, we characterized gene expression profiles from insulin-sensitive tissues, including adipose tissue, skeletal muscle, and liver tissue of Zucker diabetic fatty (ZDF) rats, a well characterized type 2 diabetes animal model.
  • Differentially regulated genes demonstrating > 1.3-fold change at age were identified and categorized through hierarchical clustering analysis.
  • Our results showed that while expression of lipolytic genes was elevated in adipose tissue of diabetic ZDF rats at 12 weeks of age, expression of lipogenic genes was decreased in liver but increased in skeletal muscle of 12 week old diabetic ZDF rats.
  • These results suggest that impairment of hepatic lipogenesis accompanied with the reduced lipogenesis of adipose tissue may contribute to development of diabetes in ZDF rats by increasing lipogenesis in skeletal muscle.
  • Moreover, expression of antioxidant defense genes was decreased in the liver of 12-week old diabetic ZDF rats as well as in the adipose tissue of ZDF rats both at 6 and 12 weeks of age.
  • Cytochrome P450 (CYP) genes were also significantly reduced in 12 week old diabetic liver of ZDF rats.
  • Genes involved in glucose utilization were downregulated in skeletal muscle of diabetic ZDF rats, and the hepatic gluconeogenic gene was upregulated in diabetic ZDF rats.
  • [MeSH-minor] Age Factors. Animals. Antioxidants / physiology. Cytochrome P-450 Enzyme System / genetics. Cytochrome P-450 Enzyme System / metabolism. Lipid Metabolism. Liver / physiology. Male. Molecular Sequence Data. Oligonucleotide Array Sequence Analysis. RNA / genetics. RNA / metabolism. Rats. Rats, Zucker

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  • (PMID = 15821098.001).
  • [ISSN] 0952-5041
  • [Journal-full-title] Journal of molecular endocrinology
  • [ISO-abbreviation] J. Mol. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Insulin; 63231-63-0 / RNA; 9035-51-2 / Cytochrome P-450 Enzyme System
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