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1. Nazarko L: 'Nurses must lead the discussion on HCA roles'. Nurs Times; 2008 Apr 8-14;104(14):10
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  • [Title] 'Nurses must lead the discussion on HCA roles'.

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  • (PMID = 18497231.001).
  • [ISSN] 0954-7762
  • [Journal-full-title] Nursing times
  • [ISO-abbreviation] Nurs Times
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Pereira FM, Bueno MI: Image evaluation with chemometric strategies for quality control of paints. Anal Chim Acta; 2007 Apr 11;588(2):184-91
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  • The images were converted in gray color scale histograms, the resulting data were organized into a matrix form and analyzed with the help of principal component analysis (PCA) and hierarchical cluster analysis (HCA).

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  • (PMID = 17386809.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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3. Zhao LH, Wu MH, Xiang BR: Analysis of Psoralea corylifolia L. fruits in different regions. Chem Pharm Bull (Tokyo); 2005 Aug;53(8):1054-7
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  • [Title] Analysis of Psoralea corylifolia L. fruits in different regions.
  • Application of multivariate data analysis has become a popular method in the last decades, mainly because it can provide information not otherwise accessible.
  • The information includes classification, searching similarities, finding relationships, finding physical significance to principal components, etc.
  • The results were studied by hierarchical cluster analysis (HCA) and principal components analysis (PCA).
  • [MeSH-minor] Chromatography, High Pressure Liquid. Cluster Analysis. Multivariate Analysis

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  • (PMID = 16079549.001).
  • [ISSN] 0009-2363
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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4. Skalický T, Treska V, Sutnar A, Liska V, Molácek J, Mírka H, Ferda J, Ohlídalová K, Slauf F, Novák M: [Surgical treatment of benign liver tumours--indications and results]. Zentralbl Chir; 2009 Apr;134(2):141-4
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  • [Title] [Surgical treatment of benign liver tumours--indications and results].
  • [Transliterated title] Wann sollte man benigne Lebertumoren chirurgisch behandeln?*
  • The authors present their results on the treatment of benign liver tumors.
  • Benign liver lesions were rather rare compared to malignant tumours, for which 273 patients were treated within the same period.
  • The most often found benign -lesions were hepatocellular adenoma, focal nodular hyperplasia (FNH) and hemangioma.
  • Sometimes, it was not possible to make a correct diagnosis preoperatively.
  • The surgical procedures used for benign tumours were mostly enucleation and non-anatomic parenchyma-saving resection (55.4 %).
  • [MeSH-major] Adenoma, Liver Cell / surgery. Focal Nodular Hyperplasia / surgery. Hemangioma / surgery. Hepatectomy / methods. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cystadenoma / diagnosis. Cystadenoma / surgery. Diagnosis, Differential. Diagnostic Imaging. Female. Hamartoma / diagnosis. Hamartoma / surgery. Humans. Lymphangioma / diagnosis. Lymphangioma / surgery. Male. Middle Aged. Young Adult

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  • (PMID = 19382044.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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5. Erdogan D, Busch OR, van Delden OM, Ten Kate FJ, Gouma DJ, van Gulik TM: Management of spontaneous haemorrhage and rupture of hepatocellular adenomas. A single centre experience. Liver Int; 2006 May;26(4):433-8
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  • [Title] Management of spontaneous haemorrhage and rupture of hepatocellular adenomas. A single centre experience.
  • BACKGROUND: Hepatocellular adenomas (HCA) may present with spontaneous haemorrhage and rupture.
  • The aim of this study was to assess management in 22 patients treated for haemorrhage and/or rupture of HCA.
  • PATIENTS AND METHODS: Between May 1990 and July 2005, 22 female patients were diagnosed with acute haemorrhage and/or rupture of lesions highly suspicious of HCA.
  • One patient underwent acute partial liver resection, whereas four patients underwent laparotomy with initial packing of the liver.
  • In one patient, selective embolisation of the left hepatic artery was performed.
  • Only in seven patients, histopathological examination showed HCA, and in one patient, HCA with focal nodular hyperplasia.
  • CONCLUSION: HCA with haemorrhage and/or rupture does not necessarily require immediate liver resection.
  • [MeSH-major] Adenoma, Liver Cell / complications. Hemorrhage / etiology. Hemorrhage / therapy. Liver Neoplasms / complications
  • [MeSH-minor] Adult. Embolization, Therapeutic. Female. Humans. Liver / pathology. Liver / surgery. Middle Aged. Retrospective Studies. Rupture. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16629646.001).
  • [ISSN] 1478-3223
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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6. Herbst U, Fuchs JI, Teubner W, Steinberg P: Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Toxicol Appl Pharmacol; 2006 Apr 15;212(2):136-45
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  • [Title] Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
  • Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HCAs) ingested with food have repeatedly been suggested to be involved in the malignant transformation of colon epithelial cells.
  • In order to test this hypothesis, HCEC cells (SV40 large T antigen-immortalized human colon epithelial cells) were incubated with a racemic mixture of benzo[c]phenanthrene dihydrodiol epoxides (B[c]PhDE), extremely potent carcinogenic PAH metabolites in vivo, or with 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP), the N-hydroxylated metabolite of the most abundant HCA in cooked meat.
  • First, it was shown that HCEC cells express sulfotransferase 1A1, which is needed to metabolize N-OH-PhIP to the corresponding N-sulfonyloxy derivative, the direct precursor molecule of genotoxic nitrenium ions.
  • Thereafter, exponentially growing HCEC cells were exposed five times to 0.1 microg (0.37 nmol) B[c]PhDE/ml for 30 min or 0.72 microg (3 nmol) N-OH-PhIP/ml for 24 h.
  • Chemically treated HCEC cells showed an enhanced saturation density and grew faster than the corresponding solvent-treated cell cultures.
  • After five treatment cycles, HCEC(B[c]PhDE) as well as HCEC(N-OH-PhIP) cells lost cell-cell contact inhibition and started piling up and forming foci in the culture flasks.
  • Furthermore, HCEC(B[c]PhDE) and HCEC(N-OH-PhIP) cells were injected i.m. into SCID mice.
  • Within 6 weeks after injection, eight animals out of eight injected with HCEC(B[c]PhDE) or HCEC(N-OH-PhIP) cells developed tumors at the site of injection, thus demonstrating the high tumorigenic potential of the HCEC(B[c]PhDE) and HCEC(N-OH-PhIP) cell cultures.
  • Taken together, we show for the first time that the abovementioned active PAH metabolites as well as N-OH-PhIP are indeed able to malignantly transform human colon epithelial cells in vitro.
  • [MeSH-major] Carcinogens / toxicity. Cell Transformation, Neoplastic / drug effects. Colon / cytology. Epithelial Cells / physiology. Epoxy Compounds / toxicity. Imidazoles / toxicity. Phenanthrenes / toxicity. Pyridines / toxicity
  • [MeSH-minor] Animals. Blotting, Western. Cell Proliferation / drug effects. Dimethyl Sulfoxide / pharmacology. Humans. Immunohistochemistry. Mice. Mice, SCID

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  • (PMID = 16137733.001).
  • [ISSN] 0041-008X
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Epoxy Compounds; 0 / Imidazoles; 0 / Phenanthrenes; 0 / Pyridines; 124489-20-9 / 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; YOW8V9698H / Dimethyl Sulfoxide
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7. Strobel D, Seitz K, Blank W, Schuler A, Dietrich C, von Herbay A, Friedrich-Rust M, Kunze G, Becker D, Will U, Kratzer W, Albert FW, Pachmann C, Dirks K, Strunk H, Greis C, Bernatik T: Contrast-enhanced ultrasound for the characterization of focal liver lesions--diagnostic accuracy in clinical practice (DEGUM multicenter trial). Ultraschall Med; 2008 Oct;29(5):499-505
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  • [Title] Contrast-enhanced ultrasound for the characterization of focal liver lesions--diagnostic accuracy in clinical practice (DEGUM multicenter trial).
  • PURPOSE: To evaluate the diagnostic benefit of contrast-enhanced ultrasound for the differential diagnosis of liver tumors in clinical practice.
  • MATERIALS AND METHODS: From May 2004 to December 2006 1349 patients (male 677, female 672) with a hepatic tumor lacking a definite diagnosis based on B-mode ultrasound and power Doppler ultrasound were examined at 14 hospitals by contrast-enhanced ultrasound using a standardized protocol (pulse/phase inversion imaging, mechanical index < 0.4).
  • The diagnosis established after contrast-enhanced ultrasound was compared to histology (> 75% cases) or in some cases to CT or MRI.
  • RESULTS: The final diagnosis of hepatic tumors included 573 benign hepatic tumors (hemangiomas n = 242, focal nodular hyperplasia n = 170, hepatocellular adenoma n = 19, other benign lesions n = 142) and 755 malignant hepatic tumors (metastases n = 383, hepatocellular carcinoma n = 279, other malignant lesions n= 93).
  • The overall diagnostic accuracy of contrast-enhanced ultrasound in comparison to the correct final diagnosis based on the combined gold standard was 90.3%.
  • Contrast-enhanced ultrasound was able to correctly assess 723/755 malignant lesions (sensitivity 95.8%) and 476/573 benign lesions (specificity 83.1%).
  • The positive predictive value of contrast-enhanced ultrasound for the diagnosis of a malignant tumor was 95.4% and the negative predictive value of contrast-enhanced ultrasound was 95.7%.
  • CONCLUSION: Contrast-enhanced ultrasound clearly improves the differential diagnosis of hepatic tumors and is very helpful in clinical practice when B-scan or power Doppler morphological criteria are missing.
  • [MeSH-major] Liver Neoplasms / ultrasonography

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  • [CommentIn] Ultraschall Med. 2009 Apr;30(2):125-7 [19340726.001]
  • (PMID = 19241506.001).
  • [ISSN] 0172-4614
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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8. Catasus L, D'Angelo E, Pons C, Espinosa I, Prat J: Expression profiling of 22 genes involved in the PI3K-AKT pathway identifies two subgroups of high-grade endometrial carcinomas with different molecular alterations. Mod Pathol; 2010 May;23(5):694-702
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  • Expression profiling of 22 genes involved in PI3K-AKT signaling pathway was analyzed in 38 endometrial carcinomas using TaqMan low-density array (TLDA) analysis.
  • The gene expression pattern was analyzed by hierarchical clustering analysis.
  • Unsupervised clustering divided the high-grade endometrial carcinomas into two clusters.
  • Almost all non-endometrioid adenocarcinomas (serous and clear cell adenocarcinomas) were segregated into this cluster.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cluster Analysis. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Middle Aged. Signal Transduction / genetics. Tissue Array Analysis. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20173732.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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9. Delmo Walter EM, Hübler M, Alexi-Meskishvili V, Miera O, Weng Y, Loforte A, Berger F, Hetzer R: Staged surgical palliation in hypoplastic left heart syndrome and its variants. J Card Surg; 2009 Jul-Aug;24(4):383-91
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  • [Title] Staged surgical palliation in hypoplastic left heart syndrome and its variants.
  • BACKGROUND: Surgical options for infants with hypoplastic left heart syndrome (HLHS) and/or its variants are cardiac transplantation or the heart-preserving staged palliation with Norwood operation,followed by a two-staged Fontan procedure.
  • The causes of mortality were sepsis, capillary leak,or heart failure.
  • One patient underwent heart transplantation after the second stage because of heart failure.
  • Among 34 Norwood survivors, four are slightly tachypneic from a mild pulmonary hyperperfusion; one presents symptoms of minimal brain disease.
  • Lower operative weight, ascending aortic size, prolonged duration of cardiopulmonary bypass, and hypothermic circulatory arrest were identified to significantly influence early mortality after the Norwood procedure.
  • [MeSH-major] Cardiovascular Surgical Procedures / methods. Hypoplastic Left Heart Syndrome / mortality. Hypoplastic Left Heart Syndrome / surgery. Outcome Assessment (Health Care). Palliative Care
  • [MeSH-minor] Abnormalities, Multiple. Aorta / pathology. Arrhythmias, Cardiac / mortality. Body Weight. Cardiopulmonary Bypass / statistics & numerical data. Circulatory Arrest, Deep Hypothermia Induced. Female. Follow-Up Studies. Heart Failure / mortality. Humans. Infant. Infant, Newborn. Male. Multivariate Analysis. Retrospective Studies. Risk Factors. Sepsis / mortality. Time Factors

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  • (PMID = 19040407.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Wang D, Lagerstrom R, Sun C, Bishof L, Valotton P, Götte M: HCA-vision: Automated neurite outgrowth analysis. J Biomol Screen; 2010 Oct;15(9):1165-70
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  • [Title] HCA-vision: Automated neurite outgrowth analysis.
  • Automating the analysis of neurons in culture represents a key aspect of the search for neuroactive compounds.
  • A number of commercial neurite analysis software packages tend to measure some basic features such as total neurite length and number of branching points.
  • The authors have developed a suite of image analysis tools that will allow researchers to produce quality analyses at primary screening rates.
  • In mixed cell populations, neurons can be filtered and separated from other brain cell types so that neurite analysis can be performed only on neurons.
  • It supports batch processing with a built-in database to store the batch-processing results, a batch result viewer, and an ad hoc query builder for users to retrieve features of interest.
  • The suite of tools has been deployed into a software package called HCA-Vision.
  • The free version of the software package is available at http://www.hca-vision.com.

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  • (PMID = 20855562.001).
  • [ISSN] 1552-454X
  • [Journal-full-title] Journal of biomolecular screening
  • [ISO-abbreviation] J Biomol Screen
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor
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11. ACHE Gold Medal Award. A high-flying career. HCA's Bovender feted for his outside contributions. Mod Healthc; 2007 Jan 29;37(5):28
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  • [Title] ACHE Gold Medal Award. A high-flying career. HCA's Bovender feted for his outside contributions.

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  • (PMID = 17319005.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Bovender J
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12. Evans CT, Hershow RC, Chin A, Foulis PR, Burns SP, Weaver FM: Bloodstream infections and setting of onset in persons with spinal cord injury and disorder. Spinal Cord; 2009 Aug;47(8):610-5
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  • [Title] Bloodstream infections and setting of onset in persons with spinal cord injury and disorder.
  • OBJECTIVE: Health-care-associated (HCA) bloodstream infection (BSI) has been shown to be a distinct epidemiologic category in the general adult population, but few studies have examined specific patient populations.
  • The objective of this study was to assess characteristics associated with BSI that occurred in the hospital (hospital-acquired, HA BSI), from health-care contact outside the hospital (HCA BSI) or in the community (community-acquired, CA BSI) in veterans with spinal cord injury and disorder (SCI&D).
  • RESULTS: Four hundred and thirteen episodes of BSI occurred in 226 patients, with a rate of 7.2 BSI episodes per 100 admissions: 267 (64.7%) were HA BSI, 110 (26.6%) were HCA BSI and 36 (8.7%) were CA BSI.
  • Antibiotic resistance was more common in those with HA BSI (65.5%) compared with that in those with HCA (49.1%, P=0.001) and CA BSI (22.2%, P<0.0001).
  • Methicillin resistance in Staphylococcus aureus was highly prevalent; HA BSI (84.5%), HCA BSI (60.6%) and CA BSI (33.3%).
  • CONCLUSION: HCA BSI comprises one-quarter of all BSIs in hospitalized patients with SCI&D.
  • Although those with HCA and CA BSI share similarities, several differences in medical characteristics and causal microorganism are noted.
  • Treatment and management strategies for HCA and CA infections need to vary.

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  • (PMID = 19238165.001).
  • [ISSN] 1476-5624
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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13. Holst RM, Laurini R, Jacobsson B, Samuelsson E, Sävman K, Doverhag C, Wennerholm UB, Hagberg H: Expression of cytokines and chemokines in cervical and amniotic fluid: relationship to histological chorioamnionitis. J Matern Fetal Neonatal Med; 2007 Dec;20(12):885-93
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  • OBJECTIVE: To correlate cervical and amniotic fluid cytokines and macrophage-related chemokines to the development of histological chorioamnionitis (HCA) in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PPROM).
  • STUDY DESIGN: Cervical and amniotic fluid interleukin (IL)-6, IL-8, IL-18, monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 from pregnant women (at <or=34 weeks of gestation) in PTL (N = 42) were analyzed and related to the subsequent occurrence of HCA or inflammatory signs in the placenta.
  • RESULTS: Intra-amniotic levels of IL-6, IL-8, IL-18, MCP-1, and MCP-3 were significantly higher in PTL cases with HCA compared to non-HCA controls, whereas no such relationship was obtained in the PPROM group.
  • Cervical IL-8 and IL-6 (but not IL-18, MCP-1, MCP-2, and MCP-3) in PTL patients was associated with HCA, and at a cut-off level of 10.0 ng/mL cervical IL-8 was a strong predictor of HCA in the PTL cases (sensitivity 100%, specificity 67%, positive predictive value 63%, negative predictive value 100%).
  • The cytokine and chemokine levels in the group with inflammatory signs were generally higher than in controls but lower compared to the concentrations in the HCA group.
  • CONCLUSIONS: The amniotic levels of IL-6, IL-8, IL-18, and the CC-chemokines MCP-1 and MCP-3 in PTL patients all predicted HCA, whereas only IL-8 was a clinically useful marker of HCA in the cervical fluid.

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  • (PMID = 18050018.001).
  • [ISSN] 1476-7058
  • [Journal-full-title] The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • [ISO-abbreviation] J. Matern. Fetal. Neonatal. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Chemokine CCL2; 0 / Chemokines; 0 / Cytokines; 0 / Interleukins
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14. Hancock H, Campbell S, Ramprogus V, Kilgour J: Role development in health care assistants: the impact of education on practice. J Eval Clin Pract; 2005 Oct;11(5):489-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In nursing this has resulted in the delegation of 'nursing care' to health care assistants (HCAs).
  • This study sought to evaluate the impact of a HCA Development Programme on care delivery.
  • Secondly, it sought to understand the preparedness of HCAs to undertake the programme and the new roles set for them.
  • Semi-structured interviews were conducted with four HCAs, eight of each of their colleagues and four patients.
  • For part two, 12 HCAs were interviewed.
  • Data were analysed following the principles of thematic analysis.
  • FINDINGS: The findings for part one showed positive changes to the HCAs' role, which included skill and knowledge development, increased confidence and initiative and a more holistic approach to care.
  • The HCAs in part two voiced positive and negative views of their role development.
  • Of the 12 HCAs interviewed, eight were prepared to attend the programme, two were undecided, and two were reluctant to attend.
  • CONCLUSIONS: The findings indicated that while the HCA Development Programme positively influenced the role of the HCA, there was a need to invest more into preparation for the restructuring of roles.

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  • (PMID = 16164591.001).
  • [ISSN] 1356-1294
  • [Journal-full-title] Journal of evaluation in clinical practice
  • [ISO-abbreviation] J Eval Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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15. Henriksen U, Fog J, Loechel F, Praestegaard M: Profiling of multiple signal pathway activities by multiplexing antibody and GFP-based translocation assays. Comb Chem High Throughput Screen; 2008 Aug;11(7):537-44
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  • [Title] Profiling of multiple signal pathway activities by multiplexing antibody and GFP-based translocation assays.
  • Multiplexing of GFP based and immunofluorescence translocation assays enables easy acquisition of multiple readouts from the same cell in a single assay run.
  • Immunofluorescence assays monitor translocation, phosphorylation, and up/down regulation of endogenous proteins.
  • GFP-based assays monitor translocation of stably expressed GFP-fusion proteins.
  • Such assays may be multiplexed along (vertical), across (horizontal), and between (branch) signal pathways.
  • 1) The MK2-GFP assay monitors translocation of MK2-GFP from the nucleus to the cytoplasm in response to stimulation of the p38 pathway.
  • By applying different immunofluorescent assays to the MK2 assay, a multiplexed HCA system is created for deconvolution of p38 pathway activation including assay readouts for MK2, p38, NFkappaB, and c-Jun.
  • 2) A method for evaluating GPCR activation and internalization in a single assay run has been established by multiplexing GFP-based internalization assays with immunofluorescence assays for downstream transducers of GPCR activity: pCREB (cAMP sensor), NFATc1 (Ca(2+) sensor), and ERK (G-protein activation).
  • 3) Cell toxicity readouts can be linked to primary readouts of interest via acquisition of secondary parameters describing cellular morphology.
  • The ATF6 Redistribution assay is provided as an example.
  • These multiplex strategies provide a unique opportunity to enhance HCA data quality and save time during drug discovery.
  • From a single assay run, several assay readouts are obtained that help the user to deconvolute the mode of action of test compounds.
  • [MeSH-major] Antibodies / analysis. Green Fluorescent Proteins / analysis. Signal Transduction

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  • (PMID = 18694390.001).
  • [ISSN] 1386-2073
  • [Journal-full-title] Combinatorial chemistry & high throughput screening
  • [ISO-abbreviation] Comb. Chem. High Throughput Screen.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.- / Phosphotransferases
  • [Number-of-references] 23
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16. National Toxicology Program: NTP technical report on the toxicology and carcinogenesis studies of beta-myrcene (CAS No. 123-35-3) in F344/N rats and B6C3F1 mice (Gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Dec;(557):1-163
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  • Except for lesion incidence data in groups administered 2 g/kg or less, data from rats that died early were excluded from the analysis and summary tables.
  • Right kidney and liver weights of dosed males and females were generally significantly greater than those of the vehicle controls.
  • The right kidney weights of 1 g/kg females and the liver weights of females administered 0.5 or 1 g/kg were significantly increased.
  • In the standard evaluation of the kidney, the incidence of renal tubule adenoma was significantly increased in 0.5 g/kg male rats, and the combined incidences of renal tubule adenoma or carcinoma were significantly increased in 0.25 and 0.5 g/kg males.
  • In both the extended evaluation and the combined standard and extended evaluations, the incidences of renal tubule adenoma and the combined incidences of renal tubule adenoma or carcinoma were significantly increased in the 0.25 and 0.5 g/kg groups of males.
  • The incidences of liver neoplasms were significantly increased in 0.25 and/or 0.5 g/kg males and 0.25 g/kg females.
  • Liver neoplasms included hepatocellular adenoma and hepatocellular carcinoma in males and females and hepatoblastoma in males.
  • The incidences of hepatocellular hypertrophy were significantly increased in 0.5 g/kg males and females, as was the incidence of mixed cell focus in 0.5 g/kg females.
  • GENETIC TOXICOLOGY: beta-myrcene did not show evidence of genotoxicity in assays conducted by the NTP.
  • No mutagenicity was observed in any of several strains of Salmonella typhimurium or Escherichia coli in two independent Ames assays conducted with and without exogenous metabolic activation.
  • There was equivocal evidence of carcinogenic activity of beta-myrcene in female F344/N rats based on increased incidences of renal tubule adenoma.
  • There was clear evidence of carcinogenic activity of beta-myrcene in male B6C3F1 mice based on increased incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatoblastoma.
  • There was equivocal evidence of carcinogenic activity of beta-myrcene in female B6C3F1 mice based on marginally increased incidences of hepatocellular adenoma and carcinoma.
  • Administration of beta-myrcene induced nonneoplastic lesions in the kidney of male and female rats, nose of male rats, and liver of male and female mice.
  • [MeSH-major] Adenoma / chemically induced. Carcinoma, Hepatocellular / chemically induced. Hepatoblastoma / chemically induced. Kidney Neoplasms / chemically induced. Liver Neoplasms / chemically induced. Monoterpenes / toxicity. Neoplasms, Experimental / chemically induced

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  • (PMID = 21415873.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Monoterpenes; 123-35-3 / beta-myrcene
  • [Investigator] Chan PC; Cesta MF; Sills RC; Bishop JB; Bristol DW; Bucher JR; Chhabra RS; Foster PM; Herbert RA; Hooth MJ; King-Herbert AP; Kissling GE; Malarkey DE; Roycroft JH; Sanders JM; Smith CS; Travlos GS; Walker NJ; Witt KL
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17. Veteläinen R, Erdogan D, de Graaf W, ten Kate F, Jansen PL, Gouma DJ, van Gulik TM: Liver adenomatosis: re-evaluation of aetiology and management. Liver Int; 2008 Apr;28(4):499-508
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  • [Title] Liver adenomatosis: re-evaluation of aetiology and management.
  • BACKGROUND: Liver adenomatosis (LA) is a rare benign parenchymal liver disease with unknown aetiology.
  • In recent reports, LA has been associated with hepatic steatosis, with potential implications for the management of this disease.
  • CONCLUSION: Liver adenomatosis is a progressive, benign parenchymal disease mainly occurring in females.
  • There is a potential link with hepatic steatosis with implications for the management of patients with LA.
  • Noninvasive diagnosis is difficult because of the variety of tumoral and nontumoral components.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Adenoma, Liver Cell / surgery. Hepatectomy / methods. Liver Neoplasms / pathology. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Cohort Studies. Evaluation Studies as Topic. Female. Follow-Up Studies. Humans. Immunohistochemistry. Liver Function Tests. Male. Middle Aged. Retrospective Studies. Risk Assessment. Treatment Outcome. Ultrasonography, Doppler

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  • [CommentIn] Liver Int. 2009 Jan;29(1):142 [18828785.001]
  • (PMID = 18339077.001).
  • [ISSN] 1478-3231
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 57
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18. Lee KH, Lee BM: Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia. J Toxicol Environ Health A; 2007 Mar 1;70(5):388-92
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  • [Title] Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia.
  • (-)-Hydroxycitric acid (HCA) is widely used as an ingredient for nutritional supplements aimed at reducing food intake, appetite, and body weight.
  • In this study, the genotoxicity of HCA was evaluated using three tests: a bacterial reverse mutation assay (Ames test), an in vitro chromosomal aberration (CA) test, and an in vivo micronucleus (MN) test.
  • HCA was negative by the Ames test in the presence or absence of a microsomal metabolizing system.
  • HCA did not induce mutagenic activity in the Ames test, and no significant mutagenic potency was indicated by CA tests.
  • However, HCA significantly and dose-dependently increased the number of MNPCEs (micronucleated polychromatic erythrocytes/1000 polychromatic erythrocytes) and PCE/(PCE + NCE) ratios according to the MN test.
  • These results suggest that HCA preferentially induce micronuclei.
  • [MeSH-minor] Animals. Cell Line. Chromosome Aberrations / chemically induced. Cricetinae. Cricetulus. Garcinia cambogia. Mice. Mutagenicity Tests

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  • [CommentIn] J Toxicol Environ Health A. 2008;71(5):348-9; author reply 350-1 [18214809.001]
  • (PMID = 17454564.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Citrates; 8W94T9026R / hydroxycitric acid
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19. Lim SH, Feng L, Kemling JW, Musto CJ, Suslick KS: An optoelectronic nose for the detection of toxic gases. Nat Chem; 2009 Oct;1(7):562-7
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  • The sensor consists of a disposable array of cross-responsive nanoporous pigments with colours that are changed by diverse chemical interactions with analytes.
  • Different TICs were identified readily using a standard chemometric approach (hierarchical clustering analysis), with no misclassifications over 140 trials.

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  • (PMID = 20160982.001).
  • [ISSN] 1755-4349
  • [Journal-full-title] Nature chemistry
  • [ISO-abbreviation] Nat Chem
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES016011-03; United States / NIEHS NIH HHS / ES / U01 ES016011; United States / NIEHS NIH HHS / ES / U01 ES016011-03; United States / NIEHS NIH HHS / ES / U01ES016011
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gases
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20. Kacerovský M, Drahosová M, Hornychová H, Plísková L, Bolehovská R, Förstl M, Tosner J, Lesko D, Andrýs C: [Amniotic fluid interleukin 6 levels in preterm premature rupture of membranes]. Ceska Gynekol; 2009 Dec;74(6):403-10
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  • OBJECTIVE: The purpose of this study was to determinate the changes of amniotic fluid interleukin 6 (IL-6) concentrations in patients with preterm premature rupture of the membranes (PPROM), and in the presence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA).
  • The aim was to examine amniotic fluid IL-6 in relation to MIAC and HCA.
  • Twenty-eight of 37 patients placentas were collected and assessed for presence or absence HCA.
  • RESULTS: There was significant difference in the median amniotic fluid IL-6 concentration between patients with preterm rupture of the membranes with and without MIAC and HCA (patients with MIAC and HCA: median 915 pg/ml, range 651-1854 pg/ml vs. patients without MIAC and HCA: median 780 pg/ml, range 184-1059 pg/ml; p=0.047).
  • There was no significant difference in the median amniotic fluid IL-6 concentration between patients with preterm rupture of the membranes with and without HCA (patients with HCA: median 829 pg/ml, range 195-1992 pg/ml vs. patients without HCA: median 768 pg/ml, range 184-1890 pg/ml; p = 0.31).
  • CONCLUSION: Amniotic fluid IL-6 concentrations patients with PPROM with presence HCA and MIAC were significantly higher than IL-6 concentration patients without HCA and MIAC.

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  • (PMID = 21246786.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] CZE
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Interleukin-6
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21. Renaud S, Hays AP, Brannagan TH 3rd, Sander HW, Edgar M, Weimer LH, Olarte MR, Dalakas MC, Xiang Z, Danon MJ, Latov N: Gene expression profiling in chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol; 2005 Feb;159(1-2):203-14
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  • Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups.
  • Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis.
  • [MeSH-minor] Adult. Aged. Chronic Disease. Female. Humans. Male. Middle Aged. Oligonucleotide Array Sequence Analysis / methods. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction / genetics. Sural Nerve / pathology. Up-Regulation


22. Puangsombat K, Smith JS: Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary. J Food Sci; 2010 Mar;75(2):T40-7
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  • Heterocyclic amines (HCAs) are mutagenic compounds formed during cooking muscle foods at high temperature.
  • Inhibition of HCAs by rosemary extracts were evaluated with beef patties cooked at 191 degrees C (375 degrees F) for 6 min each side and 204 degrees C (400 degrees F) for 5 min each side.
  • The 5 extracts were directly added to beef patties at 3 levels (0.05%, 0.2%, and 0.5%) before cooking and HCA contents were extracted and quantified.
  • There was no statistical difference in the inhibition of HCAs in the 0.05%, 0.2%, and 0.5% rosemary extracts.
  • When cooking at 204 degrees C (400 degrees F) for 5 min each side, rosemary extracts 10E and 20E were superior to rosemary extracts 100W, 30E, and 40E in inhibiting HCA formation.
  • The inhibiting effect of rosemary extracts on HCA formation corresponded to their antioxidant activity based on a DPPH scavenging assay.
  • It is possible that these compounds might act synergistically in inhibiting the formation of HCAs.
  • [MeSH-major] Antioxidants / pharmacology. Heterocyclic Compounds, 2-Ring / analysis. Meat Products / analysis. Plant Extracts / pharmacology. Rosmarinus
  • [MeSH-minor] Animals. Cattle. Cooking / methods. Ethanol. Food Analysis / methods. Food Handling / methods. Gas Chromatography-Mass Spectrometry / methods. Imidazoles / analysis. Quinoxalines / analysis. Solid Phase Microextraction / methods. Time Factors. Water

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  • (PMID = 20492265.001).
  • [ISSN] 1750-3841
  • [Journal-full-title] Journal of food science
  • [ISO-abbreviation] J. Food Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Heterocyclic Compounds, 2-Ring; 0 / Imidazoles; 0 / Plant Extracts; 0 / Quinoxalines; 059QF0KO0R / Water; 3K9958V90M / Ethanol; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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23. Silva JP, Fonseca Ld, Baumgratz JF, Castro RM, Franchi SM, Lianza AC, Vila JH: Hypoplastic left heart syndrome: the report of a surgical strategy and comparative results of Norwood x Norwood-Sano approach. Rev Bras Cir Cardiovasc; 2007 Apr-Jun;22(2):160-8
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  • [Title] Hypoplastic left heart syndrome: the report of a surgical strategy and comparative results of Norwood x Norwood-Sano approach.
  • OBJECTIVES: To report a surgical strategy for the Norwood procedure in the hypoplastic left heart syndrome (HLHS) that enables short hypothermic circulatory arrest time and aortic arch reconstruction with autologous pericardium patch.
  • Cannulation of the ductus arteriosus for systemic perfusion was the main part of the surgical strategy to reduce the hypothermic circulatory arrest time.
  • Hypothermic circulatory arrest times were 45.79+/-1.99 min and 36,8+/-1,52 min (p=0,0012), respectively.
  • CONCLUSIONS: This surgical strategy resulted in short circulatory arrest time, low mortality and low incidence of aortic coarctation.
  • [MeSH-major] Aortic Valve / surgery. Bioprosthesis. Heart Valve Prosthesis / standards. Hypoplastic Left Heart Syndrome / surgery. Pericardium / transplantation
  • [MeSH-minor] Anastomosis, Surgical. Brazil / epidemiology. Female. Heart Valve Prosthesis Implantation / mortality. Heart Ventricles / surgery. Humans. Infant, Newborn. Length of Stay. Male. Pulmonary Artery / surgery. Pulmonary Circulation. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17992320.001).
  • [Journal-full-title] Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular
  • [ISO-abbreviation] Rev Bras Cir Cardiovasc
  • [Language] eng; por
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Brazil
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24. Apostolakis E, Shuhaiber JH: Antegrade or retrograde cerebral perfusion as an adjunct during hypothermic circulatory arrest for aortic arch surgery. Expert Rev Cardiovasc Ther; 2007 Nov;5(6):1147-61
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  • [Title] Antegrade or retrograde cerebral perfusion as an adjunct during hypothermic circulatory arrest for aortic arch surgery.
  • Three methods of cerebral protection have been applied between 1975 and today: hypothermic circulatory arrest as a basic method, either alone or with antegrade cerebral perfusion (ACP), or retrograde cerebral perfusion (RCP) as an adjunctive method.
  • ACP obtains a near-physiologic brain perfusion, with homogenous distribution of blood throughout the capillary beds, and extends the safe time of hypothermic circulatory arrest to 80 min, allowing the completion of whatever aortic arch work is necessary.

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  • (PMID = 18035930.001).
  • [ISSN] 1744-8344
  • [Journal-full-title] Expert review of cardiovascular therapy
  • [ISO-abbreviation] Expert Rev Cardiovasc Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 92
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25. Ge M, Zhao H, Wang W, Zhang Z, Yu X, Li W: Terahertz time-domain spectroscopy of four hydroxycinnamic acid derivatives. J Biol Phys; 2006 Nov;32(5):403-12
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  • The well-resolved absorption spectra of the hydroxycinnamic acid (HCA) derivatives, caffeic acid, ferulic acid, sinapic acid and chlorogenic acid, were measured over the frequency region from 0.3 to 2.0 THz at 294 K with terahertz time-domain spectroscopy (THz-TDS).
  • Theoretical calculation was applied to assist the analysis and assignment of the individual THz absorption spectra of the HCA derivatives with density functional theory (DFT).
  • The real and imaginary parts of dielectric function of the four HCA derivatives were also obtained.

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  • (PMID = 19669446.001).
  • [ISSN] 0092-0606
  • [Journal-full-title] Journal of biological physics
  • [ISO-abbreviation] J Biol Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2651536
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26. Ruiz López D, Sánchez Salvador J, Fernández Martín C, Antón Díaz E: [Hepatic adenoma related to oral contraceptives use]. Aten Primaria; 2005 Feb 15;35(2):109-10
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  • [Title] [Hepatic adenoma related to oral contraceptives use].
  • [Transliterated title] Adenoma hepático en relación con la toma de anticonceptivos orales.

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  • (PMID = 15727756.001).
  • [ISSN] 0212-6567
  • [Journal-full-title] Atencion primaria
  • [ISO-abbreviation] Aten Primaria
  • [Language] SPA
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Contraceptives, Oral
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27. Flemming P, Lehmann U, Steinemann D, Kreipe H, Wilkens L: [Hepatocellular adenoma. Malignancy potential and differentiation from hepatocellular carcinoma]. Pathologe; 2006 Jul;27(4):238-43
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  • [Title] [Hepatocellular adenoma. Malignancy potential and differentiation from hepatocellular carcinoma].
  • [Transliterated title] Leberzelladenom. Entartungspotenzial und Abgrenzung vom hepatozellulären Karzinom.
  • In contrast to hepatocellular carcinoma (HCC), very few molecular pathological studies have been carried out on hepatocellular adenoma (HCA).
  • Particularly from the surgical point of view, based on views passed on verbally and in the literature of the 1970s and 1980s, a possible degeneration of the HCA provides grounds for operating.
  • Published cases of transitions from HCA into HCC were evaluated on the basis of today's morphological standards.
  • A comparison was made between the patterns of new molecular pathological studies of HCA, above all the work of our own groups, and those of HCC.
  • The results speak against the suggestion that a typical solitary HCA in pre-menopausal women is a precursor lesion of HCC.
  • After a critical review of the literature, only one casuistic case of a transition of HCA to HCC under a hormone therapy, which is no longer practiced today, remained.
  • A limitation of particular HCA in genetic and metabolic diseases, children, adult males, adenomatosis, and HCA-like tumors with known risk factors of HCC would seem pragmatically meaningful.
  • With classic HCA, however, the oncological indication for surgery does not apply.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Middle Aged

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  • (PMID = 16736176.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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28. Duffin C: Healthcare assistants seen as more involved in patient care than nurses. Nurs Stand; 2006 Aug 16;20(49):5
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  • Patients have said that healthcare assistants (HCAs), not nurses, give most of the direct care they receive in hospital, research published in this week's Nursing Standard reveals.

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  • (PMID = 28086443.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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29. Shum-Tim D, MacDonald D, Takayuki S, Laliberté E, Chen J, Jamal AM, Philip A, Platt R: Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest. Pediatr Crit Care Med; 2005 May;6(3):319-26
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  • [Title] Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest.
  • OBJECTIVE: The objective of this study was to evaluate the systemic and cerebral effects of different postoperative hematocrit management following cardiopulmonary bypass and deep hypothermic circulatory arrest.
  • INTERVENTIONS: Twelve piglets were subjected to cardiopulmonary bypass (hematocrit = 25%) and 100 mins of deep hypothermic circulatory arrest (15 degrees C).
  • Near-infrared spectroscopy and immunohistochemical assays for cerebral transforming growth factor-beta(1) and caspase-3 were performed.
  • CONCLUSIONS: Lower postoperative hematocrit was associated with increased fluid retention, lower perfusion pressure, and worse cerebrovascular injury following deep hypothermic circulatory arrest.
  • Postoperative hematocrit management may have profound systemic and cerebral effects after deep hypothermic circulatory arrest and merits further investigation.

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  • (PMID = 15857532.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins; 0 / Oxyhemoglobins; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1; 9008-02-0 / deoxyhemoglobin; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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30. Halstead JC, Etz C, Meier DM, Zhang N, Spielvogel D, Weisz D, Bodian C, Griepp RB: Perfusing the cold brain: optimal neuroprotection for aortic surgery. Ann Thorac Surg; 2007 Sep;84(3):768-74; discussion 774
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  • We used a survival porcine model to explore the physiologic characteristics and behavioral benefits of various protocols involving hypothermic circulatory arrest (HCA) and SCP.
  • METHODS: Thirty pigs (26.3 +/- 1.4 kg), cooled to 15 degrees C on cardiopulmonary bypass, using alpha-stat pH management (mean hematocrit 30%), were randomly allocated to differing brain protection strategies: 90 minutes of HCA (group A); 30 minutes of HCA, then 60 minutes of SCP (group B); or 90 minutes of SCP (group C).
  • RESULTS: Cerebral blood flow was significantly higher (p = 0.0001) during SCP (60 and 90 minutes) if preceded by HCA.
  • However, an initial period of HCA does not seem to impair late outcome; perhaps the elevated CBF and CMRO2 observed reflect a beneficial cerebral response to a recoverable insult.
  • Clearly, 90 minutes of HCA induces permanent brain injury, even in this carefully controlled setting.
  • [MeSH-major] Aorta / surgery. Cerebrovascular Circulation. Heart Arrest, Induced

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  • (PMID = 17720373.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] S88TT14065 / Oxygen
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31. Chen Y, Zhu SB, Xie MY, Nie SP, Liu W, Li C, Gong XF, Wang YX: Quality control and original discrimination of Ganoderma lucidum based on high-performance liquid chromatographic fingerprints and combined chemometrics methods. Anal Chim Acta; 2008 Aug 15;623(2):146-56
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  • Then different pattern recognition procedures, including hierarchical cluster analysis (HCA), principal component analysis (PCA), partial least squares-discrimination analysis (PLS-DA) and soft independent modeling of class analogy (SIMCA) were applied to classify the G. lucidum samples according to their cultivated origins.
  • Furthermore, four marker constituents were screened out to be the most discriminant variables, which could be applied to accurate discrimination and quality control of G. lucidum by quantitative analysis.
  • [MeSH-minor] Chromatography, High Pressure Liquid. Cluster Analysis. Discriminant Analysis. Pattern Recognition, Automated. Principal Component Analysis. Quality Control

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  • (PMID = 18620918.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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32. Sun Y, Sinicrope FA: Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells. Mol Cancer Ther; 2005 Jan;4(1):51-9
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  • [Title] Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells.
  • Sulindac sulfide inhibits cyclooxygenase (COX)-mediated prostaglandin synthesis and retards the growth of cultured colon cell lines primarily by inducing apoptosis.
  • Given the known role of mitogen-activated protein kinase (MAPK) in signal transduction and the regulation of cell survival and death, we determined the effect of sulindac sulfide on MAPK activation, COX-2 expression, and apoptosis induction in HCA-7 human colon cancer cells.
  • Similar results were seen in HCT-15 cells and also with the selective COX-2 inhibitor NS398.
  • [MeSH-minor] Antineoplastic Agents / toxicity. Cell Line, Tumor. Colonic Neoplasms. Cyclooxygenase Inhibitors / toxicity. Drug Synergism. Flavonoids / toxicity. Humans. Nitrobenzenes / toxicity. Sulfonamides / toxicity

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  • (PMID = 15657353.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK56378
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one; 0 / Antineoplastic Agents; 0 / Cyclooxygenase Inhibitors; 0 / Enzyme Inhibitors; 0 / Flavonoids; 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; 184SNS8VUH / Sulindac; 6UVA8S2DEY / sulindac sulfide; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 2.7.12.2 / MAP Kinase Kinase 1
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33. Brandt K, Langhans W, Geary N, Leonhardt M: Beneficial and deleterious effects of hydroxycitrate in rats fed a high-fructose diet. Nutrition; 2006 Sep;22(9):905-12
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  • OBJECTIVE: The present study assessed whether long-term supplementation of a high-fructose diet with hydroxycitrate (HCA), an inhibitor of de novo lipogenesis that is widely used as a non-prescription dietary aid, decreases food intake, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats.
  • METHODS: We examined the effects of HCA (1.8% of diet) on food intake, body weight gain, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats during a 4-wk period of ad libitum access to a 50% fructose diet after a 3-wk period of food restriction in which they lost about 20% of their body weight.
  • RESULTS: HCA decreased food intake and weight gain throughout the test and reduced visceral fat accumulation compared with control rats fed ad libitum (CON).
  • Rats that were pair-fed (PF) to the HCA rats showed similar decreases in weight gain and visceral fat.
  • HCA did not ameliorate the hypertriglyceridemia induced by high-fructose feeding.
  • HCA improved insulin sensitivity on day 10 in comparison with CON rats, but by day 27 insulin levels were similarly higher and liver glycogen levels were similarly lower in HCA and CON rats in comparison with PF rats.
  • Liver lipid content was elevated in HCA rats compared with CON and PF rats.
  • CONCLUSION: These findings indicate that, although HCA attenuates body weight gain and visceral fat accumulation by reducing food intake under these conditions, it has no lasting beneficial effects on hypertriglyceridemia and hyperinsulinemia and leads to the accumulation of liver lipids.
  • [MeSH-major] Citrates / administration & dosage. Energy Intake / drug effects. Fructose / administration & dosage. Intra-Abdominal Fat / drug effects. Liver / metabolism. Weight Gain / drug effects

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  • (PMID = 16829028.001).
  • [ISSN] 0899-9007
  • [Journal-full-title] Nutrition (Burbank, Los Angeles County, Calif.)
  • [ISO-abbreviation] Nutrition
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Citrates; 30237-26-4 / Fructose; 8W94T9026R / hydroxycitric acid
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34. Meybohm P, Hoffmann G, Renner J, Boening A, Cavus E, Steinfath M, Scholz J, Bein B: Measurement of blood flow index during antegrade selective cerebral perfusion with near-infrared spectroscopy in newborn piglets. Anesth Analg; 2008 Mar;106(3):795-803, table of contents
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  • BACKGROUND: Neonates with complex congenital heart defects have traditionally undergone surgery during deep hypothermic cardiac arrest (HCA).
  • We investigated SCP with different flow rates compared with HCA with respect to cerebral perfusion and tissue oxygenation as assessed by near-infrared spectroscopy.
  • METHODS: Twenty-one piglets were placed on cardiopulmonary bypass at 18 degrees C, then underwent either HCA or SCP at 25 or 50 mL x kg(-1) x min(-1) for 90 min.
  • RESULTS: Both BFI and FV(mean) increased significantly (126 +/- 27% of baseline; 19 +/- 2 cm/s) in the SCP 50 group compared with HCA (no flow) and SCP 25 (65 +/- 24%; 10 +/- 1 cm/s), respectively.
  • TOI increased in the SCP 50 group compared with baseline (74 +/- 4% vs 65 +/- 4%), and was higher compared with HCA (52 +/- 2%) and SCP 25 (59 +/- 2%).
  • CONCLUSIONS: Both BFI and FV(mean) suggested increased cerebral perfusion in the SCP 50 group compared with the HCA and SCP 25 groups.
  • TOI was significantly higher in both the SCP 25 and SCP 50 groups compared with HCA.
  • [MeSH-major] Brain / blood supply. Brain Ischemia / prevention & control. Cardiopulmonary Bypass / adverse effects. Cerebrovascular Circulation. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Monitoring, Intraoperative / methods. Perfusion / methods. Spectroscopy, Near-Infrared


35. Nishimura O, Suzuki T, Hosoba S, Takashima N, Hiramatsu N, Kinoshita T, Kambara A, Matsubayashi K, Asai T: [Acute type A aortic dissection, developed shortly after aortic valve replacement and coronary artery bypass grafting]. Kyobu Geka; 2010 Dec;63(13):1141-4
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  • Under hypothermic circulatory arrest with femoral arterial and venous cannulations, the ascending aorta was replaced and re-implantation of the saphenous vein graft was carried out.
  • [MeSH-major] Aneurysm, Dissecting / etiology. Aortic Aneurysm, Thoracic / etiology. Coronary Artery Bypass. Heart Valve Prosthesis Implantation
  • [MeSH-minor] Acute Disease. Aged. Angina Pectoris / surgery. Aortic Valve Insufficiency / surgery. Humans. Male. Postoperative Complications. Reoperation

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  • (PMID = 21174664.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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36. De Francesco MA, Gargiulo F, Schreiber C, Ciravolo G, Salinaro F, Manca N: Detection and genotyping of human papillomavirus in cervical samples from Italian patients. J Med Virol; 2005 Apr;75(4):588-92
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  • In order to assess the epidemiological incidence and frequency of different HPV types, we applied a polymerase chain reaction (PCR)-direct sequencing approach based on the use of MY09/MY11 primers as compared to Hybrid Capture assay.
  • [MeSH-minor] Adolescent. Adult. Carcinoma in Situ / virology. Female. Genotype. Humans. Italy. Middle Aged. Sequence Analysis, DNA

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15714493.001).
  • [ISSN] 0146-6615
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Galloro V: Emory, HCA to end venture. Cultural differences, control cited as obstacles. Mod Healthc; 2010 Jul 19;40(29):16
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  • [Title] Emory, HCA to end venture. Cultural differences, control cited as obstacles.

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  • (PMID = 20695116.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] United States
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38. De Felice C, Goldstein MR, Parrini S, Verrotti A, Criscuolo M, Latini G: Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis. Pediatr Crit Care Med; 2006 Mar;7(2):138-42
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  • OBJECTIVE: No reliable clinical markers of histologic chorioamnionitis (HCA), a major and often subclinical cause of prematurity leading to high neonatal morbidity and mortality, are available to date.
  • PATIENTS AND INTERVENTION: Pulse oximetry-derived signals (pulse rate, oxygen saturation, and perfusion index), recorded within the first 1.5 hrs of life, were analyzed for 110 very low-birth-weight infants, of whom 54 had histopathological evidence of HCA.
  • MEASUREMENTS AND MAIN RESULTS: Four different time series parameters were determined for nonlinear dynamical (NLD) analysis.
  • Significantly decreased Lempel-Ziv, Lyapunov largest exponent, and correlation dimension, with significantly increased Hurst values for heart rate and perfusion index (p < .00001), were observed in newborns with HCA.
  • Heart rate Lempel-Ziv </=0.218 showed 100% sensitivity (95% confidence interval, 98.8-100) and 100% specificity (95% confidence interval, 98.6-100) in distinguishing cases from controls, with positive and negative predictive values of 100% and 95.7%, respectively.
  • CONCLUSIONS: Our findings indicate that early autonomic tone balance abnormalities are present in newborns with HCA and suggest that early dynamic analysis of pulse oximetry signals could be useful in identifying affected infants.
  • [MeSH-major] Chorioamnionitis / diagnosis. Chorioamnionitis / pathology. Infant, Premature

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  • (PMID = 16474255.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Trask OJ, Nickischer D, Burton A, Williams RG, Kandasamy RA, Johnston PA, Johnston PA: High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer. Methods Mol Biol; 2009;565:159-86
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  • [Title] High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer.
  • The integration of fluorescent microscopy imaging technologies and image analysis into high-content screening (HCS) has been applied throughout the drug discovery pipeline to identify, evaluate, and advance compounds from early lead generation through preclinical candidate selection.
  • In this chapter we describe the development, validation, and implementation of an HCS assay to screen compounds from a kinase-focused small-molecule library to identify inhibitors of the p38 pathway using the GE InCell 3000 automated imaging platform.
  • The assay utilized a genetically modified HeLa cell line stably expressing mitogen-activated, protein-activating protein kinase-2 fused to enhanced green fluorescent protein (MK2-EGFP) and measured the subcellular distribution of the MK2-EGFP as a direct readout of p38 activation.
  • The MK2-EGFP translocation assay performed in 384-well glass bottom microtiter plates exhibited a robust Z-factor of 0.46 and reproducible EC50 and IC50 determinations for activators and inhibitors, respectively.
  • Thirty-one compounds exhibited IC50s less than 1 microM, and at least one novel structural class of p38 inhibitor was identified using this HCA/HCS chemical biology screening approach.
  • [MeSH-major] Drug Evaluation, Preclinical / methods. Enzyme Inhibitors / analysis. Microscopy, Confocal / methods. p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
  • [MeSH-minor] Calcium / metabolism. HeLa Cells. Humans

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  • (PMID = 19551362.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; SY7Q814VUP / Calcium
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40. Wu Y, Na N, Zhang S, Wang X, Liu D, Zhang X: Discrimination and identification of flavors with catalytic nanomaterial-based optical chemosensor array. Anal Chem; 2009 Feb 1;81(3):961-6
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  • Hierarchical cluster analysis (HCA) and linear discriminant analysis (LDA) were used to analyze the patterns.
  • [MeSH-major] Flavoring Agents / analysis. Luminescent Measurements / methods. Nanostructures / chemistry
  • [MeSH-minor] Catalysis. Discriminant Analysis. Metal Nanoparticles / chemistry. Nanotubes, Carbon / chemistry. Temperature. Time Factors

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  • (PMID = 19119818.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Flavoring Agents; 0 / Nanotubes, Carbon
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41. Kim DH, Kim SU, Nam DH, Choi YJ, Park SM, Lee CK, Kim DY: A case of hepatocellular carcinoma within hepatocellular adenoma in a non-cirrhotic male. Korean J Intern Med; 2009 Jun;24(2):147-52
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  • [Title] A case of hepatocellular carcinoma within hepatocellular adenoma in a non-cirrhotic male.
  • Hepatocellular adenoma (HA) is a benign hepatic lesion that predominantly occurs in young women.
  • Most hepatocellular carcinomas (HCC) arise in a cirrhotic liver during the fifth or sixth decades.
  • We have recently encountered a 53-year-old man who had a liver mass in a non-cirrhotic liver, and the liver mass was compatible with HA on the pre-operative computed tomography.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Precancerous Conditions / pathology

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  • (PMID = 19543495.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 26
  • [Other-IDs] NLM/ PMC2698597
  • [Keywords] NOTNLM ; Adenoma / Hepatocellular / Hepatocellular carcinoma
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42. Basaran I, Sinan S, Cakir U, Bulut M, Arslan O, Ozensoy O: In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds. J Enzyme Inhib Med Chem; 2008 Feb;23(1):32-6
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  • These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B.

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  • (PMID = 18341250.001).
  • [ISSN] 1475-6366
  • [Journal-full-title] Journal of enzyme inhibition and medicinal chemistry
  • [ISO-abbreviation] J Enzyme Inhib Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Coumarins; 0 / Enzyme Inhibitors; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II
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43. Fichera A, Little N, Dougherty U, Mustafi R, Cerda S, Li YC, Delgado J, Arora A, Campbell LK, Joseph L, Hart J, Noffsinger A, Bissonnette M: A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model. J Surg Res; 2007 Oct;142(2):239-45
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  • Our aim was to evaluate the anti-inflammatory and chemopreventive efficacy of the vitamin D analogue Ro26-2198 in the AOM/DSS model and in vitro in HCA-7 colon cancer cells.
  • For in vitro studies, HCA-7 cells were treated with Ro26-2198 followed by interleukin-1beta (IL-1beta).
  • Proliferation was measured by WST-1 assay.
  • In vitro, Ro26-2198 inhibited IL-1beta-induced ERK activation and COX-2 induction and decreased HCA-7 cell proliferation.
  • [MeSH-minor] Animals. Anti-Inflammatory Agents / pharmacology. Cell Division / drug effects. Cell Line, Tumor. Colon / metabolism. Colon / pathology. Cyclooxygenase 2 / metabolism. Disease Models, Animal. Extracellular Signal-Regulated MAP Kinases / metabolism. Humans. Interleukin-1beta / pharmacology. MAP Kinase Signaling System / drug effects. Male. Mice. Mice, Inbred A. Proto-Oncogene Proteins c-myc / metabolism. Up-Regulation / drug effects

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  • (PMID = 17574271.001).
  • [ISSN] 0022-4804
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA036745; United States / NIDDK NIH HHS / DK / DK42086
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3; 0 / Anti-Inflammatory Agents; 0 / Interleukin-1beta; 0 / Proto-Oncogene Proteins c-myc; 1C6V77QF41 / Cholecalciferol; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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44. Ueda T, Taguchi S, Inoue Y, Kashima I: Hypothermic circulatory arrest through a left thoracotomy in a 12-year-old child with aortic coarctation. Interact Cardiovasc Thorac Surg; 2007 Feb;6(1):85-6
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  • [Title] Hypothermic circulatory arrest through a left thoracotomy in a 12-year-old child with aortic coarctation.
  • Surgical correction of adult complex aortic coarctation using hypothermic circulatory arrest often requires central cannulation to secure cerebral perfusion.
  • [MeSH-major] Aortic Coarctation / surgery. Heart Arrest, Induced. Hypothermia, Induced. Thoracotomy / methods

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  • (PMID = 17669776.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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45. Kim SA, Sung YK, Kwon BM, Yoon JH, Lee H, Ahn SG, Hong SH: 2'-Hydroxycinnamaldehyde shows antitumor activity against oral cancer in vitro and in vivo in a rat tumor model. Anticancer Res; 2010 Feb;30(2):489-94
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  • BACKGROUND: 2'-Hydroxycinnamaldehyde (HCA) exerts antitumor activity against several human cancer cell lines.
  • MATERIALS AND METHODS: The antitumor activity of HCA was assessed in oral cancer cell lines and in a rat oral tumor model.
  • RESULTS: Cell cycle analysis confirmed that HCA showed anti-proliferative activity via cell cycle arrest at the G(2)/M-phase and increased the number of cells in the sub-G(1) (apoptotic cells) phase in SCC-15 and HEp-2 oral cancer cells.
  • Additionally, direct injection of HCA into an RK3E-ras-Fluc-induced tumor significantly inhibited growth of the tumor mass.
  • Histological analysis showed that HCA decreased tumor cell proliferation and induced apoptosis in a rat tumor model.
  • CONCLUSION: Taken together, these observations suggest the potential value of HCA as a candidate for the treatment of oral cancer.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Apoptosis / drug effects. Cell Cycle / drug effects. Cinnamates / pharmacology. Mouth Neoplasms / drug therapy. Xenograft Model Antitumor Assays
  • [MeSH-minor] Animals. Blotting, Western. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / pathology. Cell Proliferation / drug effects. Humans. Immunoenzyme Techniques. In Vitro Techniques. Male. Rats. Rats, Sprague-Dawley

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  • (PMID = 20332459.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cinnamates; 0 / p-hydroxycinnamaldehyde
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46. Terkivatan T, Ijzermans JN: Hepatocellular adenoma: Should phenotypic classification direct management? Nat Rev Gastroenterol Hepatol; 2009 Dec;6(12):697-8
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  • [Title] Hepatocellular adenoma: Should phenotypic classification direct management?
  • [MeSH-major] Adenoma, Liver Cell / classification. Adenoma, Liver Cell / metabolism. Liver Neoplasms / classification. Liver Neoplasms / metabolism

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  • (PMID = 19946304.001).
  • [ISSN] 1759-5053
  • [Journal-full-title] Nature reviews. Gastroenterology & hepatology
  • [ISO-abbreviation] Nat Rev Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] England
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47. Muniz Filho RC, de Sousa SA, Pereira Fda S, Ferreira MM: Theoretical study of acid-catalyzed hydrolysis of epoxides. J Phys Chem A; 2010 Apr 22;114(15):5187-94
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  • By using chemometric tools, hierarchical cluster analysis (HCA), and principal component analysis (PCA), the MP2/6-311++G** level of theory was selected from HF, MP2, and DFT as the best method to describe the geometry of the basic skeleton (oxirane).
  • In the S(N)1 mechanism, the existence of the typical carbocation was not observed, and furthermore, the possibility of epoxide conversion to a protonated aldehyde was indicated, even in the presence of a water molecule (nucleophile).

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  • (PMID = 20334442.001).
  • [ISSN] 1520-5215
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, Chen X, Kay MA, Wang R, Bishop JM: Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A; 2007 Sep 11;104(37):14771-6
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  • [Title] Distinct pathways of genomic progression to benign and malignant tumors of the liver.
  • We used several of the genetic lesions commonly associated with human liver tumors to reconstruct genetic progression to hepatocellular carcinoma and adenoma in mouse models.
  • Hepatocellular carcinoma in both instances arose from cooperation between MET and constitutively active versions of beta-catenin.
  • In contrast, adenomas were produced by cooperation between MET and defective signaling through the transcription factor HNF1alpha.
  • Prompted by these findings, we uncovered a coincidence between activation of the protein-tyrosine kinase encoded by MET and activating mutations of beta-catenin in a subset of human hepatocellular carcinomas.
  • Inactivation of MET transgenes led to regression of hepatocellular carcinomas despite the persistence of activated beta-catenin.
  • These results offer insight into hepatic tumorigenesis, provide mouse models that should be useful in the further study of hepatic tumorigenesis and for preclinical testing, and identify a subset of human hepatocellular carcinomas that may be susceptible to combination therapy directed against Met and the Wnt signaling pathway.


49. Mazzei P, Francesca N, Moschetti G, Piccolo A: NMR spectroscopy evaluation of direct relationship between soils and molecular composition of red wines from Aglianico grapes. Anal Chim Acta; 2010 Jul 19;673(2):167-72
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  • The careful subtraction of water and ethanol signals from NMR spectra allowed to statistically recognize the metabolites to be employed in multivariate statistical methods: Principal Component Analysis (PCA), Discriminant Analysis (DA) and Hierarchical Clustering Analysis (HCA).
  • All multivariate analyses confirmed that the differentiation among the wines were related to micro-climate, and carbonate, clay, and organic matter content of soils.

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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20599031.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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50. Karni M, Bernasconi CF, Rappoport Z: Role of negative hyperconjugation and anomeric effects in the stabilization of the intermediate in SNV reactions. J Org Chem; 2008 Apr 18;73(8):2980-94
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  • The hyperconjugation ability (HCA) (i.e., the stabilization due to 2p(Calpha) --> sigma*(Cbeta-X) interaction) in 8b-8d follows the order (for X, kcal/mol) CH3S (8.5) > CF3CH2O (7.6) approximately CH3O (7.5).
  • The HCA in 8b-8d is significantly smaller than that in 7b-7d due to charge delocalization in Mu in the former.

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  • (PMID = 18376875.001).
  • [ISSN] 0022-3263
  • [Journal-full-title] The Journal of organic chemistry
  • [ISO-abbreviation] J. Org. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Anderl JL, Redpath S, Ball AJ: A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity. J Vis Exp; 2009;(27)
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  • [Title] A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity.
  • High Content Analysis (HCA) assays combine cells and detection reagents with automated imaging and powerful image analysis algorithms, allowing measurement of multiple cellular phenotypes within a single assay.
  • In this study, we utilized HCA to develop a novel assay for neurotoxicity.
  • Recently, the application of HCA to neuronal screening has been reported.
  • By labeling neuronal cells with betaIII-tubulin, HCA assays can provide high-throughput, non-subjective, quantitative measurements of parameters such as neuronal number, neurite count and neurite length, all of which can indicate neurotoxic effects.
  • Astrocytes have an integral role in the maintenance of central nervous system (CNS) homeostasis, and are associated with both neuroprotection and neurodegradation when they are activated in response to toxic substances or disease states.
  • This approach is limited by an inability to provide information on cellular localization, morphology and cell number.
  • We determined that HCA could be used to overcome these limitations and to simultaneously measure multiple features associated with gliosis - changes in GFAP expression, astrocyte hypertrophy, and astrocyte proliferation - within a single assay.
  • Recent studies have suggested that the use of astrocytes in an in vitro neurotoxicity test system may prove more relevant to human CNS structure and function than neuronal cells alone.
  • Accordingly, we have developed an HCA assay for co-culture of neurons and astrocytes, comprised of protocols and validated, target-specific detection reagents for profiling betaIII-tubulin and glial fibrillary acidic protein (GFAP).
  • This assay enables simultaneous analysis of neurotoxicity, neurite outgrowth, gliosis, neuronal and astrocytic morphology and neuronal and astrocytic development in a wide variety of cellular models, representing a novel, non-subjective, high-throughput assay for neurotoxicity assessment.
  • The assay holds great potential for enhanced detection of neurotoxicity and improved productivity in neuroscience research and drug discovery.

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  • (PMID = 19417729.001).
  • [ISSN] 1940-087X
  • [Journal-full-title] Journal of visualized experiments : JoVE
  • [ISO-abbreviation] J Vis Exp
  • [Language] eng
  • [Publication-type] Journal Article; Video-Audio Media
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3253581
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52. Jeon YK, Cheon JE, Kim SK, Wang KC, Cho BK, Park SH: Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization. Mod Pathol; 2008 Nov;21(11):1345-56
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  • [Title] Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization.
  • The presence of a pilomyxoid area was associated with shorter survival.
  • An unsupervised hierarchical clustering analysis classified the cases into three clusters: one pilomyxoid astrocytoma patient into one cluster, two pilomyxoid astrocytoma patients into another cluster, and six pilocytic astrocytoma patients and one pilomyxoid astrocytoma patient into the third cluster.
  • In conclusion, the presence of mixed-form pilomyxoid astrocytoma, the acquisition of pilocytic astrocytoma features in a recurrent tumor in pure-form pilomyxoid astrocytoma, and the above results of the genome-wide gene copy number analysis suggest that pilomyxoid astrocytoma might be a pathologically and genetically related, aggressive variant of pilocytic astrocytoma with partially different genetic alterations.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Brain / pathology. Child. Child, Preschool. Clone Cells. DNA, Neoplasm / genetics. Female. Humans. Immunoenzyme Techniques. Infant. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Survival Rate. Young Adult

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  • (PMID = 18622384.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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53. Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR: Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res; 2007 May 15;67(10):4586-94
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  • [Title] Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis.
  • Hepatocellular carcinoma (HCC) with p53 mutations is usually characterized by extensive chromosomal instability (CIN), whereas those with beta-catenin mutations have relatively less CIN and the molecular pathogenesis of these tumors is unknown.
  • Methylation of 21 genetic loci was quantitated using combined bisulfite restriction analysis.
  • Using hierarchical clustering analysis based upon the quantification of methylation levels, all HCCs were segregated into two groups characterized by either limited or extensive methylation.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. Cell Transformation, Neoplastic / genetics. DNA Methylation. Liver Neoplasms / genetics. beta Catenin / genetics

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  • [ErratumIn] Cancer Res. 2007 Jun 15;67(12):5998. Ajay, Goel [corrected to Goel, Ajay]
  • (PMID = 17510384.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA72851; United States / NCI NIH HHS / CA / R01 CA98572
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / beta Catenin
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54. Panos A, Murith N, Bednarkiewicz M, Khatchatourov G: Axillary cerebral perfusion for arch surgery in acute type A dissection under moderate hypothermia. Eur J Cardiothorac Surg; 2006 Jun;29(6):1036-9
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  • Adequate brain protection is essential and commonly performed by either antegrade selective perfusion of the brachiocephalic arteries or an interval of profound hypothermic circulatory arrest.
  • The mean duration of circulatory arrest of the lower body and brain perfusion was 39.7 (range, 24-55 min).
  • CONCLUSIONS: The absence of any major permanent neurologic deficit or any visceral damages in our patients suggests that continuous moderate hypothermic cerebral perfusion, with an interval of circulatory arrest of the lower body, is adequate for acute type A aortic dissection surgery, allowing safe open repair of the distal aortic arch.
  • [MeSH-minor] Acute Disease. Adult. Aged. Aged, 80 and over. Axillary Artery. Brain Ischemia / prevention & control. Cardiopulmonary Bypass / methods. Catheterization, Peripheral / methods. Female. Humans. Male. Middle Aged. Perfusion / methods. Treatment Outcome

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  • [CommentIn] Eur J Cardiothorac Surg. 2006 Nov;30(5):815-6; author reply 816-7 [16956768.001]
  • [CommentIn] Eur J Cardiothorac Surg. 2006 Jun;29(6):1039-40 [16675223.001]
  • (PMID = 16675240.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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55. Hidayat W, Shakaff AY, Ahmad MN, Adom AH: Classification of agarwood oil using an electronic nose. Sensors (Basel); 2010;10(5):4675-85
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  • Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA), were used to classify different types of oil.
  • The HCA produced a dendrogram showing the separation of e-nose data into three different groups of oils.
  • [MeSH-major] Electronic Nose. Plant Oils / analysis. Thymelaeaceae / chemistry
  • [MeSH-minor] Algorithms. Cluster Analysis. Neural Networks (Computer). Odorants / analysis. Principal Component Analysis

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  • (PMID = 22399899.001).
  • [ISSN] 1424-8220
  • [Journal-full-title] Sensors (Basel, Switzerland)
  • [ISO-abbreviation] Sensors (Basel)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Plant Oils
  • [Other-IDs] NLM/ PMC3292139
  • [Keywords] NOTNLM ; ANN (major topic) / HCA (major topic) / PCA (major topic) / agarwood oil (major topic) / dimensionality reduction (major topic) / e-nose (major topic)
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56. Kang M, Akbarali HI: Denitration of L-type calcium channel. FEBS Lett; 2008 Sep 3;582(20):3033-6
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  • Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCa(v)1.2b.
  • Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Ca(v)1.2 in a 1D gel assay.
  • Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates.

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  • (PMID = 18675806.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK046367-17; United States / NIDDK NIH HHS / DK / R01 DK046367; United States / NIDDK NIH HHS / DK / DK46367; United States / NIDDK NIH HHS / DK / R01 DK046367-17
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CACNA1C protein, human; 0 / Calcium Channels, L-Type; 0 / Nitrates; 3604-79-3 / 3-nitrotyrosine; 42HK56048U / Tyrosine
  • [Other-IDs] NLM/ NIHMS68998; NLM/ PMC2533528
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57. Yan S, Luo G, Wang Y, Cheng Y: Simultaneous determination of nine components in Qingkailing injection by HPLC/ELSD/DAD and its application to the quality control. J Pharm Biomed Anal; 2006 Mar 3;40(4):889-95
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  • This assay was fully validated in respect to precision, repeatability and accuracy.
  • The proposed method was successfully applied to quantify the nine ingredients in 19 different Qingkailing injection samples and by principal component analysis (PCA) and hierarchical clustering analysis (HCA), it demonstrated significant variations in the content of these compounds in the samples from different manufacturers and preparation procedures.
  • [MeSH-minor] Cluster Analysis. Light. Principal Component Analysis. Quality Control. Reproducibility of Results. Scattering, Radiation. Spectrophotometry, Ultraviolet

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  • (PMID = 16257167.001).
  • [ISSN] 0731-7085
  • [Journal-full-title] Journal of pharmaceutical and biomedical analysis
  • [ISO-abbreviation] J Pharm Biomed Anal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Qingkailing
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58. Galusca B, Dumollard JM, Lassandre S, Niveleau A, Prades JM, Estour B, Peoc'h M: Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia. Virchows Arch; 2005 Jul;447(1):18-23
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  • [Title] Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia.
  • The study aimed to evaluate the status of global DNA methylation in several types of thyroid tumors using a monoclonal antibody specific for 5-methylcytidine (5-mc) and to define the diagnosis potential of this marker.
  • 5-mc immunostaining scores were calculated in 17 papillary thyroid carcinomas (PTC), 6 follicular thyroid carcinomas (FTC), 16 follicular adenomas (FA), 19 nodular goiters (NG) and ten Hürthle cells adenomas (HCA).
  • Computerized image analysis showed a significant lower level of 5-mc immunostaining in thyroid carcinoma when compared with benign tumors or adjacent normal thyroid parenchyma (P<0.0001).
  • Overall, 5-mc accuracy to distinguish malign from benign thyroid tumors was similar to that of galectin-3 (89% versus 87%, P>0.05).
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. DNA Methylation. Goiter, Nodular / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Epigenesis, Genetic. Galectin 3 / analysis. Humans. Image Processing, Computer-Assisted. Immunohistochemistry. Reproducibility of Results

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  • (PMID = 15891902.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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59. Hur M, Yeo I, Park E, Kim YH, Yoo J, Kim E, No MH, Koh J, Kim S: Combination of statistical methods and Fourier transform ion cyclotron resonance mass spectrometry for more comprehensive, molecular-level interpretations of petroleum samples. Anal Chem; 2010 Jan 1;82(1):211-8
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  • Complex petroleum mass spectra obtained by Fourier-transform ion cyclotron resonance mass spectrometry (FTICR MS) were successfully interpreted at the molecular level by applying principle component analysis (PCA) and hierarchical clustering analysis (HCA).
  • Conventional data analyses would have been impractical with so much data.
  • HCA was also performed to group and compare samples based on selected peaks that had been grouped by PCA.
  • Subsequent heat map analyses revealed detailed compositional differences among grouped samples.
  • [MeSH-major] Cyclotrons. Fourier Analysis. Mass Spectrometry / methods. Petroleum / analysis

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  • (PMID = 19968292.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Petroleum
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60. Hillebrecht A, Klebe G: Use of 3D QSAR models for database screening: a feasibility study. J Chem Inf Model; 2008 Feb;48(2):384-96
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  • As model system isozymes of human carbonic anhydrase (hCA) are used, all results are exemplified studying affinity toward hCA II and selectivity between hCA I and II.

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  • (PMID = 18211050.001).
  • [ISSN] 1549-9596
  • [Journal-full-title] Journal of chemical information and modeling
  • [ISO-abbreviation] J Chem Inf Model
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II
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61. Kaakinen T, Alaoja H, Heikkinen J, Dahlbacka S, Laurila P, Kiviluoma K, Salomäki T, Tuominen H, Ohtonen P, Biancari F, Juvonen T: Hypertonic saline dextran improves outcome after hypothermic circulatory arrest: a study in a surviving porcine model. Ann Thorac Surg; 2006 Jan;81(1):183-90
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  • [Title] Hypertonic saline dextran improves outcome after hypothermic circulatory arrest: a study in a surviving porcine model.
  • In the present study we have assessed its potential neuroprotective efficacy in the setting of hypothermic circulatory arrest in a surviving porcine model.
  • METHODS: Twenty-four pigs were randomized to receive two 5-minute intravenous infusions (4 mL/kg) of either HSD (7.5 % saline, 6% dextran 70) or normal saline immediately after and 4 hours after a 75-minute period of hypothermic circulatory arrest at a brain temperature of 18 degrees C.
  • Intracranial pressure was lower in the HSD group from 45 minutes to 8 hours after hypothermic circulatory arrest (p = 0.03).
  • Cerebral perfusion pressure was higher in the HSD group from 45 minutes to 3 hours after hypothermic circulatory arrest (p = 0.06).
  • CONCLUSIONS: The use of HSD in experimental hypothermic circulatory arrest is associated with significantly better neurologic recovery, better histopathology, lower intracranial pressure, higher cerebral perfusion pressure, and better preservation of brain metabolism.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Dextrans / therapeutic use. Hypoxia-Ischemia, Brain / etiology. Neuroprotective Agents / therapeutic use. Reperfusion Injury / prevention & control. Saline Solution, Hypertonic / therapeutic use. Sodium Chloride / therapeutic use
  • [MeSH-minor] Animals. Behavior, Animal / drug effects. Body Temperature. Brain / pathology. Brain Chemistry. Cardiopulmonary Bypass / adverse effects. Drug Administration Schedule. Drug Evaluation, Preclinical. Female. Glucose / analysis. Infusions, Intravenous. Intracranial Pressure / drug effects. Lactates / analysis. Oxygen / analysis. Partial Pressure. Pyruvates / analysis. Random Allocation. Sus scrofa

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  • [CommentIn] Ann Thorac Surg. 2006 Jan;81(1):190 [16368361.001]
  • (PMID = 16368360.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Lactates; 0 / Neuroprotective Agents; 0 / Pyruvates; 0 / Saline Solution, Hypertonic; 0 / hypertonic saline-dextran solution; 451W47IQ8X / Sodium Chloride; IY9XDZ35W2 / Glucose; K3R6ZDH4DU / Dextrans; S88TT14065 / Oxygen
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62. Liu ZG, Sun LZ, Chang Q, Zhu JM, Dong C, Yu CT, Liu YM, Zhang HT: Should the "elephant trunk" be skeletonized? Total arch replacement combined with stented elephant trunk implantation for Stanford type A aortic dissection. J Thorac Cardiovasc Surg; 2006 Jan;131(1):107-13
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  • The stented graft, a 10-cm-long woven Dacron graft with a self-expandable stent, was implanted through the aortic arch during hypothermic circulatory arrest.
  • RESULTS: Cardiopulmonary bypass time was 166 +/- 38 minutes, and average selective cerebral perfusion and lower body arrest time was 30 +/- 15 minutes.
  • [MeSH-minor] Acute Disease. Adult. Aged. Cardiopulmonary Bypass. Chronic Disease. Female. Humans. Male. Middle Aged. Vascular Surgical Procedures / methods

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  • (PMID = 16399301.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Pele LC, Thoree V, Mustafa F, He S, Tsaprouni L, Punchard NA, Thompson RP, Evans SM, Powell JJ: Low dietary calcium levels modulate mucosal caspase expression and increase disease activity in mice with dextran sulfate sodium induced colitis. J Nutr; 2007 Nov;137(11):2475-80
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  • [Title] Low dietary calcium levels modulate mucosal caspase expression and increase disease activity in mice with dextran sulfate sodium induced colitis.
  • BALB/c mice received a normal Ca (NCa) diet (0.5% Ca), a high Ca (HCa) diet (1.5% Ca), a low Ca (LCa) diet (0.05% Ca), or a very low Ca (VLCa) diet (0.009% Ca) for 3 wk.
  • Half of the mice in each group received DSS (1.5%) for 20 d in their drinking water, and disease activity was assessed.
  • DSS-induced disease activity was higher in mice fed low dietary Ca levels [P < 0.0001, VLCa and DSS vs. NCa and DSS (NCaDSS) and P < 0.005, LCa and DSS vs. NCaDSS], and mice from the VLCa group were moribund within 11 d of DSS administration.
  • Those in the HCa group did not differ greatly from controls.
  • [MeSH-minor] Animals. Dextran Sulfate. Disease Models, Animal. Female. Inflammation. Mice. Mice, Inbred BALB C

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  • (PMID = 17951488.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U105960399
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium, Dietary; 9042-14-2 / Dextran Sulfate; EC 3.4.22.- / Caspases; SY7Q814VUP / Calcium
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64. Kazi KC, Deshpande R, Soman R, Lala M, Shah S: Liver cell adenoma with co-existing hepatic granulomas in an HIV-positive patient. Indian J Gastroenterol; 2005 Nov-Dec;24(6):274-5
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  • [Title] Liver cell adenoma with co-existing hepatic granulomas in an HIV-positive patient.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Adenoma, Liver Cell / complications. Granuloma / complications. Liver Diseases / complications. Liver Neoplasms / complications


65. Jung EM, Ross CJ, Rennert J, Scherer MN, Farkas S, von Breitenbuch P, Schnitzbauer AA, Piso P, Lamby P, Menzel C, Schreyer AG, Feuerbach S, Schlitt HJ, Loss M: Characterization of microvascularization of liver tumor lesions with high resolution linear ultrasound and contrast enhanced ultrasound (CEUS) during surgery: First results. Clin Hemorheol Microcirc; 2010;46(2-3):89-99
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  • [Title] Characterization of microvascularization of liver tumor lesions with high resolution linear ultrasound and contrast enhanced ultrasound (CEUS) during surgery: First results.
  • All patients had surgery for their hepatic tumor (hepatocellular carcinoma (HCC), cholangiocellular carcinoma (CCC), metastasis, and adenoma).
  • Than multifrequency linear transmitters (6-9 MHz, 6-15 MHz, LOGIQ E9, GE) were applied for B-scan, coulor coded Doppler sonography (CCDS) and Power Doppler followed by dynamic CEUS with Contrast Harmonic Imaging (CHI) after bolus injection of a maximum of 15 mL SonoVue®.
  • Using the 6-15 MHz multifrequency linear transducer with CHI, arterial perfusion of adenomas, neuroendocrine metastases and HCC lesions was detectable.
  • CONCLUSION: The intra-operative use of high-resolution linear transducer techniques with CEUS offers new diagnostic perspectives for an effective liver surgery.
  • [MeSH-major] Carcinoma, Hepatocellular / blood supply. Carcinoma, Hepatocellular / ultrasonography. Cholangiocarcinoma / blood supply. Cholangiocarcinoma / ultrasonography. Liver Neoplasms / blood supply. Liver Neoplasms / ultrasonography. Ultrasonography, Doppler, Color / methods
  • [MeSH-minor] Adenoma / blood supply. Adenoma / surgery. Adenoma / ultrasonography. Aged. Contrast Media. Female. Humans. Liver / surgery. Liver / ultrasonography. Male. Middle Aged. Phospholipids. Sulfur Hexafluoride

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  • (PMID = 21135485.001).
  • [ISSN] 1875-8622
  • [Journal-full-title] Clinical hemorheology and microcirculation
  • [ISO-abbreviation] Clin. Hemorheol. Microcirc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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66. Colovic R, Grubor N, Micev M, Radak V: Hepatocellular adenoma with malignant alteration. Hepatogastroenterology; 2007 Mar;54(74):386-8
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  • [Title] Hepatocellular adenoma with malignant alteration.
  • Hepatocellular adenoma is a rare benign tumor of the liver which appears almost exclusively in women taking oral contraceptives.
  • With ultrasonography and CT scan a solitary well demarcated mass within the right liver of otherwise normal appearance was diagnosed.
  • During an open surgery a solitary, unilobular, spherical, well demarcated tumor on the lower surface of the segments IVb, V and VI of the liver, 115 x 100 x 90 mm in diameter was excised.
  • The histology revealed a hepatocellular adenoma with malignant alteration.
  • The patient is the eldest presented case of malignant alteration of hepatocellular adenoma who had never taken oral contraceptives or other hormones.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Cell Transformation, Neoplastic / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Hepatectomy. Humans. Liver / pathology. Risk Factors. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 17523280.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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67. Abdo MR, Vullo D, Saada MC, Montero JL, Scozzafava A, Winum JY, Supuran CT: Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives. Bioorg Med Chem Lett; 2009 May 1;19(9):2440-3
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  • The compounds showed a weak hCA I activation profile, but were more efficient as hCA II and IX activators.
  • The 4-iodophenyl-substituted derivative behaved as a strong and isozyme selective hCA II activator, with an activation constant of 0.21muM.

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  • (PMID = 19345095.001).
  • [ISSN] 1464-3405
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Protein Isoforms; 0 / Recombinant Proteins; 0 / phenylsulfonylhydrazido l-histidine; 4QD397987E / Histidine; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
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68. Sinha R, Peters U, Cross AJ, Kulldorff M, Weissfeld JL, Pinsky PF, Rothman N, Hayes RB: Meat, meat cooking methods and preservation, and risk for colorectal adenoma. Cancer Res; 2005 Sep 1;65(17):8034-41
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  • [Title] Meat, meat cooking methods and preservation, and risk for colorectal adenoma.
  • Cooking meat at high temperatures produces heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs).
  • Meat intake may increase cancer risk as HCAs, PAHs, and N-nitroso compounds are carcinogenic in animal models.
  • We investigated meat, processed meat, HCAs, and the PAH benzo(a)pyrene and the risk of colorectal adenoma in 3,696 left-sided (descending and sigmoid colon and rectum) adenoma cases and 34,817 endoscopy-negative controls.
  • The questionnaire was linked to a previously developed database to determine exposure to HCAs and PAHs.
  • Intake of red meat, with known doneness/cooking methods, was associated with an increased risk of adenoma in the descending and sigmoid colon [odds ratio (OR), 1.26; 95% confidence interval (95% CI), 1.05-1.50 comparing extreme quintiles of intake] but not rectal adenoma.
  • Well-done red meat was associated with increased risk of colorectal adenoma (OR, 1.21; 95% CI, 1.06-1.37).
  • Increased risks for adenoma of the descending colon and sigmoid colon were observed for the two HCAs: 2-amino-3,8-dimethylimidazo[4,5]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5]pyridine (OR, 1.18; 95% CI, 1.01-1.38 and OR, 1.17, 95% CI, 1.01-1.35, respectively) as well as benzo(a)pyrene (OR, 1.18; 95% CI, 1.02-1.35).
  • Greater intake of bacon and sausage was associated with increased colorectal adenoma risk (OR, 1.14; 95% CI, 1.00-1.30); however, total intake of processed meat was not (OR, 1.04; 95% CI, 0.90-1.19).
  • Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma.
  • [MeSH-major] Adenoma / etiology. Colorectal Neoplasms / etiology. Cooking. Food Preservation. Meat

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  • (PMID = 16140978.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Imidazoles; 0 / Mutagens; 0 / Quinoxalines; 3417WMA06D / Benzo(a)pyrene; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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69. Osborne-Bossert C, Fitzgerald D, Speir A, St Onge J: Delivery of antegrade cerebral perfusion during descending aortic reconstruction: a case report. Perfusion; 2008 Mar;23(2):135-7
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  • Antegrade cerebral perfusion (ACP) has been demonstrated to be a safe and effective method of providing adequate protection to the brain during hypothermic circulatory arrest.
  • By improving oxygen delivery to the cerebral capillaries, users of this technique have reported fewer temporary neurological deficits in postoperative periods, even after prolonged periods of circulatory arrest.
  • Surgical correction of a descending aortic aneurysm can provide a challenge when the left subclavian artery is involved.
  • A period of hypothermic circulatory arrest is required to complete the proximal anastamosis of the graft.
  • A 54-year-old female presented with a computerized tomography (CT) scan of a descending aortic aneurysm, originating at the base of the left subclavian artery.

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  • (PMID = 18840584.001).
  • [ISSN] 0267-6591
  • [Journal-full-title] Perfusion
  • [ISO-abbreviation] Perfusion
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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70. Rhodes MC, Bucher JR, Peckham JC, Kissling GE, Hejtmancik MR, Chhabra RS: Carcinogenesis studies of benzophenone in rats and mice. Food Chem Toxicol; 2007 May;45(5):843-51
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  • There was a positive trend in the incidence of renal tubule adenoma in male rats; these neoplasms were accompanied by significantly increased incidences of renal tubule hyperplasia.
  • Increased incidences of mononuclear cell leukemia were observed in male rats exposed to 312 or 625 ppm benzophenone and in female rats exposed to 625 ppm benzophenone.
  • Liver lesions observed included significantly increased incidences of hepatocytic centrilobular hypertrophy in all exposed groups of rats.
  • In male mice, there were significantly increased incidences of hepatocellular adenoma in the 625 and 1250 ppm groups.
  • In female mice, the incidences of hepatocellular adenoma in the 625 and 1250 ppm groups were higher than expected after adjusting for the lower body weights in these groups.
  • Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of benzophenone in male F344/N rats based on increased incidences of renal tubule adenoma.
  • There was equivocal evidence of carcinogenic activity of benzophenone in female F344/N rats based on the marginal increased incidences of mononuclear cell leukemia and histiocytic sarcoma.
  • There was some evidence of carcinogenic activity of benzophenone in male B6C3F(1) mice based on increased incidences of hepatocellular neoplasms, primarily adenoma.
  • There was some evidence of carcinogenic activity of benzophenone in female B6C3F(1) mice based on increased incidences of histiocytic sarcoma; the incidences of hepatocellular adenoma in female B6C3F(1) mice may have been related to benzophenone exposure.
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / pathology. Animals. Dose-Response Relationship, Drug. Female. Histiocytic Disorders, Malignant / chemically induced. Histiocytic Disorders, Malignant / pathology. Kidney Neoplasms / chemically induced. Kidney Neoplasms / pathology. Leukemia / chemically induced. Leukemia / pathology. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Male. Mice. Mice, Inbred Strains. Rats. Rats, Inbred F344. Sarcoma / chemically induced. Sarcoma / pathology. Sex Factors

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  • [Cites] J Am Acad Dermatol. 2003 Nov;49(5 Suppl):S259-61 [14576646.001]
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  • (PMID = 17187913.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzophenones; 0 / Photosensitizing Agents; 701M4TTV9O / benzophenone
  • [Other-IDs] NLM/ NIHMS21944; NLM/ PMC1936973
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71. Apostolakis EE, Baikoussis NG, Katsanos K, Karanikolas M: Postoperative peri-axillary seroma following axillary artery cannulation for surgical treatment of acute type A aortic dissection. J Cardiothorac Surg; 2010;5:43
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  • Right axillary artery cannulation confers significant advantages, because it provides antegrade arterial perfusion during cardiopulmonary bypass, and allows continuous antegrade cerebral perfusion during hypothermic circulatory arrest, thereby minimizing global cerebral ischemia.
  • We herein present the case of a 36-year-old Caucasian man with known Marfan syndrome and acute type A aortic dissection, who had direct right axillary artery cannulation for surgery of the ascending aorta.

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  • (PMID = 20500837.001).
  • [ISSN] 1749-8090
  • [Journal-full-title] Journal of cardiothoracic surgery
  • [ISO-abbreviation] J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2880968
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72. Kouchoukos NT, Masetti P, Mauney MC, Murphy MC, Castner CF: One-stage repair of extensive chronic aortic dissection using the arch-first technique and bilateral anterior thoracotomy. Ann Thorac Surg; 2008 Nov;86(5):1502-9
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  • METHODS: Fifty-one patients with chronic expanding thoracic aortic dissections (48 type A, 3 type B with proximal extension) were treated with a single procedure using a bilateral anterior thoracotomy, hypothermic circulatory arrest, and reperfusion of the arch vessels first to minimize brain ischemia.
  • Forty-six patients had previous operations: for acute type A aortic dissection (n = 36), aortic valve disease (n = 6), or coronary artery disease (n = 4).
  • CONCLUSIONS: The technique is a safe and suitable alternative to the two-stage (elephant trunk technique) and hybrid procedures for treatment of chronic dissection with aneurysm of the thoracic aorta.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chronic Disease. Humans. Middle Aged. Recurrence. Reoperation. Survival Rate

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  • [CommentIn] Ann Thorac Surg. 2008 Nov;86(5):1509 [19049740.001]
  • (PMID = 19049739.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
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73. Ambrosi DJ, Tanasijevic B, Kaur A, Obergfell C, O'Neill RJ, Krueger W, Rasmussen TP: Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells. Stem Cells; 2007 May;25(5):1104-13
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  • [Title] Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells.
  • The resulting hybrids are pluripotent as judged by developmental assays, but detailed analyses of the underlying molecular-genetic control of reprogrammed transcription in such hybrids are required to better understand fusion-mediated reprogramming.
  • Comprehensive analysis of the mouse embryonic fibroblast/ESC hybrid transcriptome revealed global patterns of gene expression reminiscent of ESCs.
  • However, combined analysis of variance and hierarchical clustering analyses revealed at least seven distinct classes of differentially regulated genes in comparisons of hybrids, ESCs, and somatic cells.
  • Somatic/ESC hybrid cell lines resemble their pre-fusion ESC partners in terms of behavior in culture and pluripotency.
  • [MeSH-major] Cellular Reprogramming / genetics. Chimera / genetics. Embryonic Stem Cells / metabolism. Genome
  • [MeSH-minor] Alleles. Animals. Base Sequence. Cell Line. Chromosomes, Mammalian / genetics. Cluster Analysis. DNA Mutational Analysis. Gene Expression Profiling. Gene Expression Regulation, Developmental. Karyotyping. Mice. Molecular Sequence Data. Pluripotent Stem Cells / metabolism. Transcription, Genetic

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  • (PMID = 17272499.001).
  • [ISSN] 1066-5099
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01AG23687
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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74. Baraki H, Hagl C, Khaladj N, Kallenbach K, Weidemann J, Haverich A, Karck M: The frozen elephant trunk technique for treatment of thoracic aortic aneurysms. Ann Thorac Surg; 2007 Feb;83(2):S819-23; discussion S824-31
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  • BACKGROUND: The frozen elephant trunk technique allows for single-stage repair of combined aortic arch and descending aortic aneurysms using a hybrid prosthesis with a stented and a nonstented end.
  • The stented end of the hybrid prosthesis was placed through the opened aortic arch under fluoroscopic control using hypothermic circulatory arrest and selective antegrade cerebral perfusion.
  • In 1 patient, the descending aorta was perforated owing to misplacement of the stented end of the hybrid prosthesis.

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  • (PMID = 17257934.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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75. Horiuchi S, Kumai R, Tokunaga Y, Tokura Y: Proton dynamics and room-temperature ferroelectricity in anilate salts with a proton sponge. J Am Chem Soc; 2008 Oct 8;130(40):13382-91
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  • Dielectric measurements revealed phase transitions at T(c) = 334 and 172 K for bromanilate (Hba(-)) and chloranilate (Hca(-)) salts, respectively.

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  • (PMID = 18781747.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Xie C, Mace J, Dinno MA, Li YQ, Tang W, Newton RJ, Gemperline PJ: Identification of single bacterial cells in aqueous solution using confocal laser tweezers Raman spectroscopy. Anal Chem; 2005 Jul 15;77(14):4390-7
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  • [Title] Identification of single bacterial cells in aqueous solution using confocal laser tweezers Raman spectroscopy.
  • We report on a rapid method for reagentless identification and discrimination of single bacterial cells in aqueous solutions using a combination of laser tweezers and confocal Raman spectroscopy (LTRS).
  • The optical trapping enables capturing of individual bacteria in aqueous solution in the focus of the laser beam and levitating the captured cell well off the cover plate, thus maximizing the excitation and collection of Raman scattering from the cell and minimizing the unwanted background from the cover plate and environment.
  • Raman spectral patterns excited by a near-infrared laser beam provide intrinsic molecular information for reagentless analysis of the optically isolated bacterium.
  • We show that synchronized bacterial cells can be well-discriminated among the six species using principal component analyses (PCA).
  • Unsynchronized bacterial cells that are cultured at stationary phases can also be well-discriminated by the PCA, as well as by a hierarchical cluster analysis (HCA) of their Raman spectra.
  • We also show that unsynchronized bacteria selected from random growth phases can be classified with the help of a generalized discriminant analysis (GDA).
  • These findings demonstrate that the LTRS may find valuable applications in rapid sensing of microbial cells in diverse aqueous media.
  • [MeSH-major] Bacteria / cytology. Optical Tweezers. Spectrum Analysis, Raman / instrumentation. Spectrum Analysis, Raman / methods

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  • (PMID = 16013851.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Solutions
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77. Puccetti L, Fasolis G, Cecchi A, Winum JY, Gamberi A, Montero JL, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Bioorg Med Chem Lett; 2005 May 2;15(9):2359-64
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  • A series of such aromatic sulfonamides incorporating thioureido-sulfanilyl moieties has been prepared and investigated for its interaction with the catalytic domain of the human isozyme hCA IX.
  • Due to the highest expression of CA IX in clear renal cell carcinoma and its chemo/radioresistance, our efforts are first of all directed to generate effective therapeutic strategies for the cure of this malignancy.

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  • (PMID = 15837325.001).
  • [ISSN] 0960-894X
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carbonic Anhydrase Inhibitors; 0 / Sulfonamides; 8W8T17847W / Urea; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
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78. Réti A, Barna G, Pap E, Adleff V, L Komlósi V, Jeney A, Kralovánszky J, Budai B: Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells. Pathol Oncol Res; 2009 Sep;15(3):335-44
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  • [Title] Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells.
  • The antiproliferative effect of 5-fluorouracil (5-FU) in the presence of low dose non-steroidal anti-inflammatory drugs (NSAIDs) on high cyclooxygenase-2 (COX-2)-expressing HCA-7 and low COX-2-expressing HT-29 colon carcinoma cell lines was investigated.
  • Pharmacogenetic parameters were studied to characterize the 5-FU sensitivity of the two cell lines.
  • Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms were determined by PCR analysis.
  • Cell proliferation was measured by SRB assay, cell cycle distribution and apoptosis by FACS analysis.
  • The HT-29 cell line was found to be homozygous for TS 2R and 1494ins6 and T homozygous for MTHFR 677 polymorphisms predicting high 5-FU sensitivity (IC(50): 10 microM).
  • TS 3R homozygosity, TS 1496del6 and MTHFR 677CT heterozygosity may explain the modest 5-FU sensitivity (IC(50): 1.1 mM) of the HCA-7 cell line.
  • Indomethacin and NS-398 (10 microM and 1.77 microM, respectively) reduced the PGE(2) level in HCA-7 cells (>90%).
  • Low concentrations of NSAIDs without antiproliferative potency increased the S-phase arrest and enhanced the cytotoxic action of 5-FU only in HCA-7 cells after 48-hours treatment.
  • The presented data suggested that the enhancement of 5-FU cytotoxicity by indomethacin or NS-398 applied in low dose is related to the potency of NSAIDs to modulate the cell-cycle distribution and the apoptosis; however, it seems that this effect might be dependent on cell phenotype, namely on the COX-2 expression.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Cell Proliferation / drug effects. Cyclooxygenase 2 / metabolism. Cyclooxygenase Inhibitors / pharmacology. Fluorouracil / pharmacology
  • [MeSH-minor] Apoptosis / drug effects. Blotting, Western. Cell Line, Tumor. Cell Separation. Enzyme-Linked Immunosorbent Assay. Flow Cytometry. HT29 Cells. Humans. Indomethacin / pharmacology. Methylenetetrahydrofolate Dehydrogenase (NADP) / genetics. Microscopy, Fluorescence. Nitrobenzenes / pharmacology. Polymorphism, Genetic. Reverse Transcriptase Polymerase Chain Reaction. Sulfonamides / pharmacology. Thymidylate Synthase / genetics

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  • (PMID = 19048402.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cyclooxygenase Inhibitors; 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.5.1.5 / Methylenetetrahydrofolate Dehydrogenase (NADP); EC 2.1.1.45 / Thymidylate Synthase; U3P01618RT / Fluorouracil; XXE1CET956 / Indomethacin
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79. Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT: Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors. J Med Chem; 2005 Dec 1;48(24):7860-6
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  • A lately discovered carbonic anhydrase (hCA, EC 4.2.1.1), the mitochondrial hCA VB, was cloned, expressed, and purified.
  • Kinetic parameters proved it to be 3.37 times more effective than hCA VA as a catalyst for the physiological reaction, with kcat = 9.5 x 10(5) s(-1) and kcat/K(M) = 9.8 x 10(7) M(-1) s(-1), being second only to hCA II among the 16 isoforms presently known in humans.
  • We investigated the inhibition of hCA VB with a library of sulfonamides/sulfamates, some of which are clinically used compounds.
  • Benzenesulfonamides were ineffective inhibitors, whereas derivatives bearing 4-amino, 4-hydrazino, 4-methyl, 4-carboxy moieties or halogenated sulfanilamides were more effective (Ki's of 1.56-4.3 microM).
  • Among the 10 clinically used compounds, acetazolamide, benzolamide, topiramate, and indisulam showed effective inhibitory activity (Ki's of 18-62 nM).
  • Three compounds showed better activity against hCA VB over hCA II, among which were sulpiride and ethoxzolamide, which were 2 times more effective inhibitors of the mitochondrial over the cytosolic isozyme. hCA VB is a druggable target and some of its inhibitors may lead to the development of novel antiobesity therapies.

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  • (PMID = 16302824.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; 0 / Sulfonamides; 0 / Sulfonic Acids; 9NFU33906Q / sulfamic acid; EC 4.2.1.- / Carbonic Anhydrase V
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80. Reddy SK, Kishnani PS, Sullivan JA, Koeberl DD, Desai DM, Skinner MA, Rice HE, Clary BM: Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia. J Hepatol; 2007 Nov;47(5):658-63
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  • [Title] Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia.
  • BACKGROUND/AIMS: Because dietary modifications have prolonged the life expectancy of patients with glycogen storage disease type Ia (GSD Ia), the incidence of hepatocellular adenoma (HCA) to carcinoma (HCC) transformation is increasing.
  • The objective of this retrospective study is to assess the safety and effectiveness of HCA resection in GSD Ia patients.
  • METHODS: Clinicopathologic, peri-operative, and long-term data were reviewed from patients who underwent HCA resection.
  • Comparisons were made with Fisher's exact, Mann-Whitney U, and log-rank tests; survival was estimated with Kaplan-Meier analysis.
  • RESULTS: From 1998 to 2006, 38 patients underwent HCA resection.
  • GSD Ia patients had greater morbidity (86% vs. 20%) and shorter time to adenoma progression (median 23 months vs. not yet reached) after partial hepatectomy compared to the general population (p<0.05).
  • Three GSD Ia patients underwent liver transplantation 77, 32, and 23 months after adenoma resection.
  • CONCLUSIONS: Despite substantial morbidity, partial hepatectomy is feasible in GSD Ia patients and is an effective intermediate step in the prevention of HCC until definitive treatment with liver transplantation.
  • [MeSH-major] Adenoma, Liver Cell / surgery. Biliary Tract Surgical Procedures / statistics & numerical data. Glycogen Storage Disease Type I / complications. Liver / surgery. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Comorbidity. Disease Progression. Female. Humans. Liver Transplantation / statistics & numerical data. Male. Middle Aged. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17637480.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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81. Kakarla UK, Beres EJ, Ponce FA, Chang SW, Deshmukh VR, Bambakidis NC, Zabramski JM, Spetzler RF: Microsurgical treatment of pediatric intracranial aneurysms: long-term angiographic and clinical outcomes. Neurosurgery; 2010 Aug;67(2):237-49; discussion 250
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  • Rates of aneurysm recurrence and de novo formation were calculated.
  • Hypothermic circulatory arrest was used to treat 10 aneurysms (14%), all involving the basilar artery.
  • At angiographic follow-up (mean, 53 months; median, 32 months), the annual recurrence rate was 2.6%, and the annual rate of de novo formation or growth was 7.8%.
  • They leave higher rates of recurrence and de novo formation or growth than their adult counterparts, which mandates lifelong follow-up.

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  • (PMID = 20539250.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Della Porta MG, Malcovati L, Boveri E, Travaglino E, Pietra D, Pascutto C, Passamonti F, Invernizzi R, Castello A, Magrini U, Lazzarino M, Cazzola M: Clinical relevance of bone marrow fibrosis and CD34-positive cell clusters in primary myelodysplastic syndromes. J Clin Oncol; 2009 Feb 10;27(5):754-62
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  • [Title] Clinical relevance of bone marrow fibrosis and CD34-positive cell clusters in primary myelodysplastic syndromes.
  • CD34+ cell clusters were found in 23% of patients and were associated with WHO categories with excess of blasts (P < .001) and poor-risk cytogenetics (P = .001).
  • In multivariable analysis, BM fibrosis and presence of CD34+ cell clusters had independent negative impact on overall survival (P < .001 and P = .019, respectively) and leukemia-free survival (P < .001 and P = .004, respectively).
  • A hierarchical clustering analysis identified three subsets of patients with distinct clinical features.
  • Furthermore, the presence of CD34+ cell clusters is an independent risk factor for progression to acute leukemia.
  • [MeSH-major] Antigens, CD34 / analysis. Bone Marrow / pathology. Myelodysplastic Syndromes / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Fibrosis. Humans. Leukemia, Myelomonocytic, Acute / pathology. Male. Middle Aged. Prognosis. Retrospective Studies


83. Stav D, Bar I, Sandbank J: Gene expression subtraction of non-cancerous lung from smokers and non-smokers with adenocarcinoma, as a predictor for smokers developing lung cancer. J Exp Clin Cancer Res; 2008;27:45
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  • Hierarchical clustering analysis on genes obtained from smokers and non-smokers, after subtracting were exported to the Ingenuity Pathway Analysis software for further analysis.
  • The gene functional analysis disclosed 20 genes, which are involved in cancer process (P = 7.05E-5 to 2.92E-2).

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  • (PMID = 18811983.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
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  • [Other-IDs] NLM/ PMC2570656
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84. Minami K, Maniratanachote R, Katoh M, Nakajima M, Yokoi T: Simultaneous measurement of gene expression for hepatotoxicity in thioacetamide-administered rats by DNA microarrays. Mutat Res; 2006 Jan 31;603(1):64-73
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  • TA was intraperitoneally administered at high (400 mg/kg), medium (150 mg/kg) or low (50 mg/kg) dose (four rats per group) and then the serum and liver were collected at the indicated time (6, 12, 24, 36 and 48 h).
  • Serum biochemical markers were measured and hepatic mRNA expression profiles were analyzed by a DNA microarray.
  • Hierarchical clustering analysis of all dosage groups revealed in 2 major clusters, distinguished by an early (6 and 12h) and a late (24, 36 and 48 h) phase.
  • The major gene expression profile obtained by quality-threshold (QT) clustering analysis showed the same maximal toxic time as that estimated by the serum biochemical markers.
  • This study suggested that the major gene expression profile estimated by QT clustering would be a sensitive marker of hepatotoxicity.
  • [MeSH-minor] Alanine Transaminase / biosynthesis. Alanine Transaminase / blood. Animals. Aspartate Aminotransferases / biosynthesis. Aspartate Aminotransferases / blood. Biomarkers / analysis. Dose-Response Relationship, Drug. Male. Oligonucleotide Array Sequence Analysis. Quality Control. RNA, Messenger / biosynthesis. Rats. Rats, Sprague-Dawley. Sensitivity and Specificity

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  • (PMID = 16337175.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / RNA, Messenger; 075T165X8M / Thioacetamide; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase
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85. Liu J, Waalkes MP: Liver is a target of arsenic carcinogenesis. Toxicol Sci; 2008 Sep;105(1):24-32
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  • [Title] Liver is a target of arsenic carcinogenesis.
  • Inorganic arsenic is clearly a human carcinogen causing tumors of the skin, lung, urinary bladder, and possibly liver (IARC, 2004).
  • This forum reevaluates epidemiology studies, rodent studies together with in vitro models, and focuses on the liver as a target organ of arsenic toxicity and carcinogenesis.
  • Hepatocellular carcinoma and hepatic angiosarcoma, have been frequently associated with environmental or medicinal exposure to arsenicals.
  • Recent work in mice clearly shows that exposure to inorganic arsenic during gestation induces tumors, including hepatocellular adenoma and carcinoma, in offspring when they reach adulthood.
  • In rats, the methylated arsenicals, dimethylarsinic acid promotes diethylnitrosamine-initiated liver tumors, whereas trimethylarsine oxide induces liver adenomas.
  • Chronic exposure of rat liver epithelial cells to low concentrations of inorganic arsenic induces malignant transformation, producing aggressive, undifferentiated epithelial tumors when inoculated into the Nude mice.
  • Some of these mechanisms may be liver specific/selective.
  • Overall, accumulating evidence clearly indicates that the liver could be an important target of arsenic carcinogenesis.

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  • (PMID = 18566022.001).
  • [ISSN] 1096-0929
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens; N712M78A8G / Arsenic
  • [Number-of-references] 86
  • [Other-IDs] NLM/ PMC2734307
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86. Riesenman PJ, Tamaddon HS, Farber MA: Surgical bypass procedures to facilitate endovascular repair of aortic arch pathology. J Cardiovasc Surg (Torino); 2008 Aug;49(4):461-9
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  • Thoracic aortic lesions involving the aortic arch require more complex surgical interventions necessitating cardiopulmonary bypass, and hypothermic circulatory arrest.
  • The application of a thoracic endoprosthesis may be limited by the extent of involvement of the proximal thoracic aorta as coverage of arch vessel ostia may be necessary to obtain adequate proximal endograft fixation and aneurysm exclusion.
  • In an effort to overcome proximal landing zone limitations imposed by arch vessel involvement, hybrid surgical-endovascular reconstructive and debranching bypass procedures have been performed to create a proximal landing zone of adequate length.
  • Although these adjunctive techniques incorporate invasive surgical procedures, it is believed that minimizing the procedural invasiveness, by avoiding aortic cross-clamping and/or hypothermic circulatory arrest, morbidity and mortality outcomes can be improved especially in high-risk patients.
  • Several surgical approaches and techniques have been described for various levels of aortic arch involvement with encouraging early and mid-term results, although the long-term durability of these hybrid surgical-endovascular procedures remains to be defined.

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  • (PMID = 18665108.001).
  • [ISSN] 0021-9509
  • [Journal-full-title] The Journal of cardiovascular surgery
  • [ISO-abbreviation] J Cardiovasc Surg (Torino)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 50
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87. Hokaiwado N, Asamoto M, Ogawa K, Shirai T: Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat. Toxicol Pathol; 2005;33(6):695-701
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  • Transgenic rats featuring a dominant negative mutant of the connexin 32 gene under albumin promoter control (Cx32Delta Tg-High and Cx32Delta Tg-Low lines, respectively with high and low copy numbers of the transgene) have disrupted GJIC, as demonstrated by scrape dye-transfer assay in vivo as previous report by Asamoto et al. (2004).
  • However, incidences of adenomas and hepatocellular carcinomas were not elevated at the end of the experiment (52 weeks).
  • The results indicate that although both high and low expression of the dominant negative connexin 32 mutant gene in our rats is able to inhibit gap junctional capacity, only high expression is effective at enhancing susceptibility to early stage DEN-induced liver carcinogenesis.
  • [MeSH-major] Cell Communication / genetics. Gap Junctions / genetics. Glutathione Transferase / biosynthesis. Liver Neoplasms, Experimental / genetics. Precancerous Conditions / genetics
  • [MeSH-minor] Alkylating Agents. Animals. Animals, Genetically Modified. Cocarcinogenesis. Connexins / analysis. Connexins / genetics. Connexins / metabolism. Diethylnitrosamine. Disease Susceptibility. Enzyme Induction. Hepatectomy. Liver Regeneration / physiology. Male. Mutation. Phenobarbital / administration & dosage. Phenobarbital / pharmacology. Rats. Time Factors

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  • (PMID = 16243774.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alkylating Agents; 0 / Connexins; 0 / connexin 32; 3IQ78TTX1A / Diethylnitrosamine; EC 2.5.1.18 / Glutathione Transferase; YQE403BP4D / Phenobarbital
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88. Shiota G: Role of retinoic acid receptor in steatohepatitis-related tumor formation. J Gastroenterol Hepatol; 2007 Jun;22 Suppl 1:S101-7
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  • Retinoic acid (RA) appears to play an important role in the pathophysiology of liver disease.
  • To explore the role of RA in the liver, transgenic mice that express RA receptor (RAR) alpha-dominant negative form in hepatocytes under the control of albumin promoter and enhancer, were developed.
  • In addition, formation of H(2)O(2) and 8-hydroxy-2'-deoxyguanosine was increased.
  • After 12 months of age, these mice developed hepatocellular carcinomaand adenoma of the liver.
  • Feeding on a high-RA diet reversed histological and biochemical abnormalities and inhibited the occurrence of liver tumors.
  • These results suggest that hepatic loss of RA function leads to the development of steatohepatitis and liver tumors.
  • [MeSH-major] Carcinoma, Hepatocellular / physiopathology. Disease Models, Animal. Fatty Liver / physiopathology. Liver Neoplasms / physiopathology. Receptors, Retinoic Acid / genetics

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  • [ErratumIn] J Gastroenterol Hepatol. 2008 Mar;23(3):501-2
  • (PMID = 17567456.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Fatty Acids; 0 / Receptors, Retinoic Acid
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89. Ghaferi AA, Hutchins GM: Progression of liver pathology in patients undergoing the Fontan procedure: Chronic passive congestion, cardiac cirrhosis, hepatic adenoma, and hepatocellular carcinoma. J Thorac Cardiovasc Surg; 2005 Jun;129(6):1348-52
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  • [Title] Progression of liver pathology in patients undergoing the Fontan procedure: Chronic passive congestion, cardiac cirrhosis, hepatic adenoma, and hepatocellular carcinoma.
  • BACKGROUND: Staged palliative surgical procedures have been an effective treatment of complex congenital heart defects.
  • The Fontan procedure has been of particular benefit to infants with functional single-ventricle complexes but with the consequence of a sustained increase of right-sided venous pressure.
  • METHODS: We reviewed the clinical and pathologic features of 9 autopsied patients having undergone the Fontan procedure, with special attention given to their liver pathology.
  • Hepatic adenoma in the setting of cardiac cirrhosis was found in a patient surviving for 9 years.
  • One patient surviving for 18 years had hepatocellular carcinoma superimposed on cardiac cirrhosis.
  • Rupture of the hepatoma in this case led to fatal hemorrhage.
  • CONCLUSION: The study shows that chronically increased hepatic venous pressure from the Fontan procedure might lead to chronic passive congestion, cardiac cirrhosis, hepatic adenoma, and hepatocellular carcinoma.
  • [MeSH-major] Adenoma / etiology. Adenoma / pathology. Carcinoma, Hepatocellular / etiology. Carcinoma, Hepatocellular / pathology. Fontan Procedure / adverse effects. Heart Failure / etiology. Liver / pathology. Liver Neoplasms / etiology. Liver Neoplasms / pathology. Myocardium / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Chronic Disease. Disease Progression. Female. Fibrosis. Humans. Infant. Male

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  • (PMID = 15942576.001).
  • [ISSN] 0022-5223
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Redline RW, Minich N, Taylor HG, Hack M: Placental lesions as predictors of cerebral palsy and abnormal neurocognitive function at school age in extremely low birth weight infants (&lt;1 kg). Pediatr Dev Pathol; 2007 Jul-Aug;10(4):282-92
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  • We conducted a secondary analysis of placental pathology in a cohort study of inborn singleton ELBW infants born between 1992 and 1995 and evaluated for cerebral palsy (CP) and abnormal neurocognitive testing at 8 years of age (N = 129).
  • Histologic chorioamnionitis (HCA) was not predictive of outcome in the population as a whole, but a severe fetal vascular response was associated with a lower NEPSY score in the subpopulation with HCA (N = 69).
  • Placentas with increased syncytial knots, villous edema, and those with neither finding constituted nonoverlapping subgroups with distinct pathologic and perinatal characteristics.
  • Among infants with villous edema (N = 25), those with neurologic impairment had lower gestational ages and more severe degrees of HCA.
  • However, by logistic regression these other factors were not independent risk factors for abnormal neurocognitive testing, and only HCA with a severe fetal vascular response decreased the association of villous edema with low test scores for NEPSY, but not K-ABC.

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  • [CommentIn] Pediatr Dev Pathol. 2008 Mar-Apr;11(2):164 [18422400.001]
  • (PMID = 17638433.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Joshi AD, Corral R, Siegmund KD, Haile RW, Le Marchand L, Martínez ME, Ahnen DJ, Sandler RS, Lance P, Stern MC: Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. Carcinogenesis; 2009 Mar;30(3):472-9
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  • Diets high in red meat have been consistently associated with colorectal cancer (CRC) risk and may result in exposure to carcinogens that cause DNA damage [i.e polycyclic aromatic hydrocarbons, heterocyclic amines (HCAs) and N-nitroso compounds].
  • We tested for gene-environment interactions using case-only analyses (n = 577) and compared the results using case-unaffected sibling comparisons (n = 307 sibships).
  • Case-unaffected sibling analyses were generally supportive of the case-only results.

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  • (PMID = 19029193.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA074799; United States / NIEHS NIH HHS / ES / 5P30 ES07048; United States / PHS HHS / / 5UO1074799
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens
  • [Other-IDs] NLM/ PMC2722151
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92. Weigelt B, Horlings HM, Kreike B, Hayes MM, Hauptmann M, Wessels LF, de Jong D, Van de Vijver MJ, Van't Veer LJ, Peterse JL: Refinement of breast cancer classification by molecular characterization of histological special types. J Pathol; 2008 Oct;216(2):141-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We aimed to refine the breast cancer classification systems by analysing a series of 11 histological special types [invasive lobular carcinoma (ILC), tubular, mucinous A, mucinous B, neuroendocrine, apocrine, IDC with osteoclastic giant cells, micropapillary, adenoid cystic, metaplastic, and medullary carcinoma] using immunohistochemistry and genome-wide gene expression profiling.
  • Hierarchical clustering analysis confirmed that some histological special types constitute discrete entities, such as micropapillary carcinoma, but also revealed that others, including tubular and lobular carcinoma, are very similar at the transcriptome level.
  • Our analysis also revealed that some special types associated with a good prognosis, such as medullary and adenoid cystic carcinomas, display a poor prognosis basal-like transcriptome, providing strong circumstantial evidence that basal-like cancers constitute a heterogeneous group.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cluster Analysis. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Oligonucleotide Array Sequence Analysis. Signal Transduction / genetics. Statistics, Nonparametric


93. Coban TA, Beydemir S, Gülçin I, Ekinci D: Morphine inhibits erythrocyte carbonic anhydrase in vitro and in vivo. Biol Pharm Bull; 2007 Dec;30(12):2257-61
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  • Human erythrocyte isoenzymes, HCA-I and HCA-II, were purified by Sepharose-4B affinity chromatography column with a yield of 66.95 and 62.82%, a specific activity of 3892.3 and 11663.2 EU/mg proteins with 745.1 and 2232.6-fold purification of each isoenzyme, respectively.
  • In vitro inhibition of erythrocyte HCA-I and HCA-II by morphine using the CO(2)-hydratase enzyme gave IC(50) values 4.50 x 10(-5) M (r(2): 0.954) and 9.23 x 10(-5) M (r(2): 0.996), respectively.

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  • (PMID = 18057708.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Narcotics; 76I7G6D29C / Morphine; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II
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94. Soga M, Hashimoto S, Kishimoto Y, Hirasawa T, Makino S, Inagaki S: Insulin resistance, steatohepatitis, and hepatocellular carcinoma in a new congenic strain of Fatty Liver Shionogi (FLS) mice with the Lep(ob) gene. Exp Anim; 2010;59(4):407-19
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  • [Title] Insulin resistance, steatohepatitis, and hepatocellular carcinoma in a new congenic strain of Fatty Liver Shionogi (FLS) mice with the Lep(ob) gene.
  • In order to examine the influence of obesity on metabolic disorder and liver pathogenesis of the Fatty Liver Shionogi (FLS) mouse, which develops hereditary fatty liver and spontaneous liver tumors, we established a new congenic strain named FLS-Lep(ob).
  • The steatohepatitis-like lesions including the multifocal mononuclear cell infiltration and clusters of foamy cells were observed earlier in FLS-Lep(ob)/ Lep(ob) mice than in FLS mice.
  • B6-Lep(ob)/Lep(ob) mice did not show hepatic inflammatory change.
  • Furthermore, FLS-Lep(ob)/Lep(ob) mice developed multiple hepatic tumors including hepatocellular adenomas and carcinomas following steatohepatitis.
  • In conclusion, the FLS-Lep(ob)/Lep(ob) mice developed steatohepatitis and hepatic tumors following hepatic steatosis.

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  • (PMID = 20660987.001).
  • [ISSN] 1881-7122
  • [Journal-full-title] Experimental animals
  • [ISO-abbreviation] Exp. Anim.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Leptin; 0 / Lipids; 0 / RNA, Messenger
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95. Geramizadeh B, Bahador A, Foroutan HR, Banani A, Nikeghbalian S, Malek-Hosseini SA: Pathology of pediatric liver tumors, a single center experience from south of Iran. Indian J Pathol Microbiol; 2010 Jul-Sep;53(3):422-6
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  • [Title] Pathology of pediatric liver tumors, a single center experience from south of Iran.
  • BACKGROUND: Pediatric hepatic malignancies are rare, accounting for 1-4% of all solid childhood tumors.
  • The histopathology of childhood hepatic tumors guides the treatment and prognosis, and is the cornerstone for precise diagnosis.
  • Until now, there has been no documented study on pediatric liver tumor cases from this center; in this report, we show our experience about the common types of childhood hepatic tumors during five years (2002-2007) and compare them with other studies.
  • MATERIALS AND METHODS: During five years (2002-2007), all the hepatic tumors of childhood (under 18 year-old) from the pathology file of Namazi Hospital of Shiraz University of Medical Sciences are recorded.
  • All the slides were reviewed and the pathologic diagnosis was confirmed.
  • RESULTS: We detected 53 liver tumor cases in children (below 18 years of age).
  • Hepatoblastoma was the most common liver tumor in this age group accounting for 22 patients (41.5%).
  • The second most common primary tumor was hepatocellular carcinoma (HCC), with five patients.
  • Benign tumors included adenoma, mesenchymal hamartoma, vascular tumors, focal nodular hyperplasia, and inflammatory pseudo tumor.
  • CONCLUSIONS: The spectrum of hepatic tumors in children is different from that found in the older age group (adults) and also different in different populations.
  • [MeSH-major] Liver Neoplasms / epidemiology. Liver Neoplasms / pathology
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / pathology. Adolescent. Carcinoma, Hepatocellular / epidemiology. Carcinoma, Hepatocellular / pathology. Child. Child, Preschool. Female. Focal Nodular Hyperplasia / epidemiology. Focal Nodular Hyperplasia / pathology. Granuloma, Plasma Cell / epidemiology. Granuloma, Plasma Cell / pathology. Hamartoma / epidemiology. Hamartoma / pathology. Hepatoblastoma / epidemiology. Hepatoblastoma / pathology. Humans. Infant. Iran / epidemiology. Male. Prevalence. Retrospective Studies. Sarcoma / epidemiology. Sarcoma / pathology. Sex Distribution. Vascular Neoplasms / epidemiology. Vascular Neoplasms / pathology

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  • (PMID = 20699496.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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96. Smith J, Roberts R, Fahy S: Use of study days to develop the healthcare assistant role. Nurs Times; 2006 Jul 25-31;102(30):34-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The Department of Health's strategies to combat staff shortages and an ageing workforce have now turned their focus to the delivery of patient care by HCAs.
  • This article describes how a trust redesigned the role of HCAs and implemented a study day in order to enhance both theoretical knowledge and clinical practice for this role.

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  • (PMID = 16903305.001).
  • [ISSN] 0954-7762
  • [Journal-full-title] Nursing times
  • [ISO-abbreviation] Nurs Times
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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97. Neugebauer U, Schmid U, Baumann K, Ziebuhr W, Kozitskaya S, Holzgrabe U, Schmitt M, Popp J: The influence of fluoroquinolone drugs on the bacterial growth of S. epidermidis utilizing the unique potential of vibrational spectroscopy. J Phys Chem A; 2007 Apr 19;111(15):2898-906
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The influence of fluoroquinolone drugs on the bacterial growth of S. epidermidis utilizing the unique potential of vibrational spectroscopy.
  • In this work, vibrational spectroscopy is used to shed more light on the as-yet elusive interaction of gyrase inhibitors of the fluoroquinolone type with their biological target inside the Gram-positive bacterium Staphylococcus epidermidis by investigating whole-cell changes that occur as a result of the presence of the drug moxifloxacin.
  • The spectral changes caused by the action of the drug were analyzed with the help of statistical methods, such as hierarchical cluster analysis (HCA), principal component analysis (PCA), and Fisher's linear discriminant analysis (LDA) combined with variable selection.
  • The wavenumbers mostly affected by the action of the drug could be assigned to protein and DNA moieties, supporting the proposed mechanisms of a tertiary complex of the fluoroquinolone, the enzyme gyrase, and DNA.
  • [MeSH-minor] Aza Compounds / pharmacology. Cluster Analysis. DNA / metabolism. DNA Gyrase / metabolism. Models, Chemical. Models, Statistical. Principal Component Analysis. Quinolines / pharmacology. Spectrophotometry, Infrared. Spectrum Analysis, Raman. Time Factors. Ultraviolet Rays

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  • (PMID = 17385845.001).
  • [ISSN] 1089-5639
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Aza Compounds; 0 / Fluoroquinolones; 0 / Quinolines; 9007-49-2 / DNA; EC 5.99.1.3 / DNA Gyrase; U188XYD42P / moxifloxacin
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98. Neugebauer U, Schmid U, Baumann K, Ziebuhr W, Kozitskaya S, Deckert V, Schmitt M, Popp J: Towards a detailed understanding of bacterial metabolism--spectroscopic characterization of Staphylococcus epidermidis. Chemphyschem; 2007 Jan 8;8(1):124-37
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To fight disease and growing resistance, research interest is focused on understanding bacterial metabolism.
  • IR absorption spectroscopy reflects the overall chemical composition of the cells, with major focus on the protein vibrations.
  • Smaller sample volumes-down to a single cell-are sufficient to probe the overall chemical composition by means of micro-Raman spectroscopy.
  • In combination with statistical evaluation methods [hierarchical cluster analysis (HCA), principal component analysis (PCA), linear discriminant analysis (LDA)], the protein and nucleic-acid components that change during the different bacterial growth phases can be identified from the in vivo vibrational spectra.
  • Furthermore, tip-enhanced Raman spectroscopy (TERS) provides insight into the surface structures and follows the dynamics of the polysaccharide and peptide components on the bacterial cells with a spatial resolution below the diffraction limit.
  • [MeSH-major] Spectrophotometry, Infrared / methods. Spectrum Analysis, Raman / methods. Staphylococcus epidermidis / chemistry. Staphylococcus epidermidis / metabolism

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  • (PMID = 17146809.001).
  • [ISSN] 1439-4235
  • [Journal-full-title] Chemphyschem : a European journal of chemical physics and physical chemistry
  • [ISO-abbreviation] Chemphyschem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Nucleic Acids
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99. Correnti M, Cavazza ME, Herrera O, Rodríguez A: Presence of human papillomavirus infection determined by hybrid capture assay in cervical lesions in a Venezuelan population. Invest Clin; 2010 Mar;51(1):27-35
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  • [Title] Presence of human papillomavirus infection determined by hybrid capture assay in cervical lesions in a Venezuelan population.
  • The aim of this study was to establish the presence of HPV infection in cervical lesions in a Venezuelan population, by Hybrid Capture Assay II (HCA II), and its association with cytological diagnosis.
  • HPV infection was determined using HCA II.
  • The cytological diagnosis of the smears showed LSIL in 1120/1483 samples (75.5%), HSIL in 354/1483 (23.9%) and ASC-US, in 9/1483 (0.6%).
  • The positivity of HPV DNA detected by HCA II was 54.6% (811/1483).
  • Our study showed a high presence of cervical infection by human papillomavirus of a high risk genotype.
  • [MeSH-major] Papillomavirus Infections / diagnosis. Papillomavirus Infections / virology. Uterine Cervical Neoplasms / virology

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  • (PMID = 20815154.001).
  • [ISSN] 0535-5133
  • [Journal-full-title] Investigación clínica
  • [ISO-abbreviation] Invest Clin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Venezuela
  • [Chemical-registry-number] 0 / DNA Probes, HPV
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100. Huang X, Yu C, Jin C, Kobayashi M, Bowles CA, Wang F, McKeehan WL: Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis. Cancer Res; 2006 Feb 1;66(3):1481-90
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  • Fibroblast growth factor (FGF) signaling mediates cell-to-cell communication in development and organ homeostasis in adults.
  • Although FGFR1 is expressed by hepatic cell progenitors and adult nonparenchymal cells, ectopic expression is commonly observed in hepatoma cells.
  • Here, we determined whether ectopic FGFR1 is a cause or consequence of hepatocellular carcinoma by targeting a constitutively active human FGFR1 to mouse hepatocytes.
  • However, in diethylnitrosamine-treated mice, the chronic FGFR1 activity promoted an incidence of 44% adenomas at 4 months and 38% hepatocellular carcinoma at 8 months.
  • No adenoma or hepatocellular carcinoma was observed in diethylnitrosamine-treated wild-type (WT) livers at 4 or 8 months, respectively.
  • Isolated hepatoma cells from the transgenic tumors exhibited a growth advantage in culture.
  • Advanced hepatocellular carcinoma in the transgenic livers exhibited a reduced rate of necrosis.
  • In cooperation with an initiator, the persistent activity of ectopic FGFR1 in hepatocytes is a strong promoter of hepatocellular carcinoma by driving cell proliferation at early stages and promoting neoangiogenesis at late stages of progression.
  • [MeSH-major] Hepatocytes / metabolism. Liver Neoplasms, Experimental / metabolism. Receptor, Fibroblast Growth Factor, Type 1 / metabolism. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Animals. Carcinogens. Cell Growth Processes / physiology. Cell Transformation, Neoplastic / chemically induced. Cell Transformation, Neoplastic / metabolism. Cell Transformation, Neoplastic / pathology. DNA, Neoplasm / biosynthesis. Diethylnitrosamine. Hepatectomy. Humans. Liver / drug effects. Liver / physiology. Liver Regeneration / physiology. MAP Kinase Signaling System. Mice. Mice, Transgenic. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology

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  • (PMID = 16452204.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA 59971; United States / NIDDK NIH HHS / DK / R01 DK 35310; United States / NCI NIH HHS / CA / U01 CA 84296
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / DNA, Neoplasm; 0 / Vascular Endothelial Growth Factor A; 3IQ78TTX1A / Diethylnitrosamine; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1
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