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Items 1 to 100 of about 119
6. Nakabayashi M, Shomori K, Kiya S, Shiomi T, Nosaka K, Ito H: Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report. Yonago Acta Med; 2010 Sep;53(3):65-9

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  • [Title] Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report.
  • Basal cell adenoma (BCA) is an uncommon benign salivary gland neoplasm that includes isomorphic basaloid cells.
  • We report on a female patient with BCA that developed in the right parotid gland in her 50s.
  • Histopathologically, the tumor was characterized by multiple duct-like structures and tubular-trabecular masses composed of small isomorphic cells with hyperchromatic, round nuclei and an eosinophilic cytoplasm.

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  • (PMID = 24031120.001).
  • [ISSN] 0513-5710
  • [Journal-full-title] Yonago acta medica
  • [ISO-abbreviation] Yonago Acta Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3763784
  • [Keywords] NOTNLM ; basal cell adenoma / immunohistochemistry / parotid gland
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7. Mizota M, Tamada I, Hizukuri K, Otsubo K, Arima S, Kawano Y, Ono S, Hayashida Y, Kaji T, Takamatsu H, Sasano H: Bilateral asynchronous adrenocortical adenoma in a girl with beckwith-wiedemann syndrome. Clin Pediatr Endocrinol; 2005;14(1):23-6

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  • [Title] Bilateral asynchronous adrenocortical adenoma in a girl with beckwith-wiedemann syndrome.
  • We report a case of asynchronous occurrence of bilateral adrenocortical adenoma in a 13-yr-old girl with Beckwith-Wiedemann syndrome.
  • A right virilizing adrenal adenoma was surgically removed at age 6, following clinical manifestation of virilization such as acne, voice change, clitoris hypertrophy and overgrowth.
  • Histopathological examination of the resected specimen revealed an adrenocortical adenoma predominantly composed of eosinophilic tumor cells expressing all the steroidogenic enzymes.
  • Abdominal ultrasonography demonstrated the presence of a left adrenocortical adenoma.

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  • (PMID = 24790306.001).
  • [ISSN] 0918-5739
  • [Journal-full-title] Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology
  • [ISO-abbreviation] Clin Pediatr Endocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC4004928
  • [Keywords] NOTNLM ; Beckwith-Wiedemann syndrome / adrenal tumor / virilizing
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8. Khalifa M, Slim I, Ghannouchi N, Kaabia N, Sriha B, Letaief A, Bahri F: Eosinophilic fasciitis and toxic thyroid adenoma--a novel association. Acta Clin Belg; 2008 May-Jun;63(3):197-9
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  • [Title] Eosinophilic fasciitis and toxic thyroid adenoma--a novel association.
  • Eosinophilic fasciitis is characterized by skin induration, peripheral blood eosinophilia, hypergammaglobulinaemia and thickening, fibrosis and inflammatory cell infiltration of the fascia.
  • There have been several reports of illness particularly haematological disorders in patients with eosinophilic fasciitis.
  • However, their association with thyroid disorders has rarely been described and includes autoimmune thyroiditis rather than toxic thyroid adenoma.
  • We describe a case of a 53-year-old woman with simultaneous association of eosinophilic fasciitis and subclinical hyperthyroidism caused by toxic thyroid adenoma.
  • [MeSH-major] Adenoma / complications. Eosinophilia / complications. Fasciitis / complications. Thyroid Neoplasms / complications

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  • (PMID = 18714852.001).
  • [ISSN] 1784-3286
  • [Journal-full-title] Acta clinica Belgica
  • [ISO-abbreviation] Acta Clin Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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9. Schittenhelm J, Ebner FH, Harter P, Bornemann A: Symptomatic intraspinal oncocytic adrenocortical adenoma. Endocr Pathol; 2009;20(1):73-7
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  • [Title] Symptomatic intraspinal oncocytic adrenocortical adenoma.
  • The excised tumor was composed of nests of large polygonal cells with eosinophilic partial granular cytoplasm.
  • The diagnosis of an oncocytic adrenal cortical adenoma was made.
  • Oncocytic tumors are rare neoplasms and they comprise non-functioning variants of adrenal cortical adenomas.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenocortical Adenoma / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 19039533.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Dundr P, Povýsil C, Zelinka T, Tvrdík D, Ciprová V, Novák K: Adrenocortical adenoma with rhabdoid features. Pathol Res Pract; 2006;202(3):177-81
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  • [Title] Adrenocortical adenoma with rhabdoid features.
  • We report a case of an aldosterone producing adrenocortical adenoma with rhabdoid features in a 16-year-old girl.
  • Histologically, the tumor was composed of approximately equal parts of tumor cells with rhabdoid features arranged in a solid and trabecular pattern and cells characterized by compact eosinophilic cytoplasm, solid growth with focal necroses, and increased mitotic activity.
  • Rhabdoid features have been described in many tumors of variable histogenesis; however, to the best of our knowledge, the presence of rhabdoid phenotype has never been described in either adrenocortical adenoma or carcinoma.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Rhabdoid Tumor / metabolism

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  • (PMID = 16448785.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 4964P6T9RB / Aldosterone
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11. Odashiro M, Lima MG, Miiji LN, Odashiro DN, Carvalho GV, Prates Campos JC, Odashiro AN: Infiltrating syringomatous adenoma of the nipple. Breast J; 2009 Jul-Aug;15(4):414-6
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  • [Title] Infiltrating syringomatous adenoma of the nipple.
  • Infiltrating syringomatous adenoma of the nipple is a rare, benign, locally invasive tumor with recurrence potential, showing sweat duct differentiation.
  • The lining cells were small, cuboidal with a central nuclei and eosinophilic nuclei.
  • Patient has no signs of progression of disease in 1 year of follow-up.
  • [MeSH-major] Adenoma / surgery. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Nipples / pathology. Syringoma / surgery

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  • (PMID = 19470133.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Torlakovic EE, Gomez JD, Driman DK, Parfitt JR, Wang C, Benerjee T, Snover DC: Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). Am J Surg Pathol; 2008 Jan;32(1):21-9
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  • [Title] Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA).
  • The morphologic distinction between various serrated polyps of the colorectum may be challenging.
  • The distinction between sessile serrated adenoma (SSA) and traditional serrated adenoma (TSA) may be difficult using currently available criteria mostly based on cytologic characteristics.
  • We have evaluated 66 serrated polyps including 29 SSA, 18 TSA, and 19 hyperplastic polyps for overall shape of the polyps, architectural features of individual crypts, the presence of eosinophilic cytoplasm, size and distribution of the proliferation and maturation zones, as well as Ki-67 and CK20 expression.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology. Intestinal Polyps / pathology

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  • [ErratumIn] Am J Surg Pathol. 2008 Mar;32(3):491
  • (PMID = 18162766.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Ki-67 Antigen
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13. Hoch BL, Wu M, Lewis M, Gan L, Burstein DE: An immunohistochemical study of XIAP expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma. J Oral Pathol Med; 2008 Nov;37(10):634-8
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  • [Title] An immunohistochemical study of XIAP expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma.
  • The biological progression from pleomorphic adenoma (PA) to carcinoma ex pleomorphic adenoma (CXPA) has been poorly understood.
  • Tumor cells with strong staining often exhibited cytological atypia in the form of nuclear enlargement and contour irregularity, prominent nucleoli and eosinophilic cytoplasm.
  • CONCLUSION: Increased expression of XIAP from PA to cellular PA to CXPA and in atypical cells within cellular areas of PA adds to our growing understanding of defective apoptotic pathways in malignant transformation in this group of salivary gland tumors and suggests an adenoma to adenocarcinoma model of progression.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Cell Transformation, Neoplastic / metabolism. Salivary Gland Neoplasms / metabolism. X-Linked Inhibitor of Apoptosis Protein / biosynthesis

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  • (PMID = 18673415.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / X-Linked Inhibitor of Apoptosis Protein; 0 / XIAP protein, human
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4. Chen ZM, Scudiere JR, Abraham SC, Montgomery E: Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma. Am J Surg Pathol; 2009 Feb;33(2):186-93
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  • [Title] Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma.
  • Pyloric gland adenoma (PGA) is a rare neoplasm demonstrating gastric epithelial differentiation.
  • We compared them to 28 gastric foveolar type gastric adenomas (GTAs) from 25 patients.
  • Morphologically, PGAs were characterized by closely packed pyloric gland-type tubules with a monolayer of cuboidal to low columnar epithelial cells containing round nuclei and pale to eosinophilic cytoplasm with a ground glass appearance.
  • Despite its bland histologic appearance, it is much more likely to be accompanied by background IM and autoimmune gastritis and can evolve into invasive adenocarcinoma displaying pyloric gland differentiation.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Stomach Neoplasms / pathology

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  • (PMID = 18830123.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucin-6
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15. Saqi A, Giorgadze TA, Eleazar J, Remotti F, Vazquez MF: Clear cell and eosinophilic oncocytomas of salivary gland: cytological variants or parallels? Diagn Cytopathol; 2007 Mar;35(3):158-63
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  • [Title] Clear cell and eosinophilic oncocytomas of salivary gland: cytological variants or parallels?
  • Oncocytomas are uncommon tumors of the salivary gland.
  • They have an abundance of mitochondria, which is manifested as granular eosinophilic cytoplasm by light microscopy.
  • Two forms of oncocytoma, eosinophilic and clear cell, have been described in the surgical pathology literature.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Eosinophils / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 17415919.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Akiyama T, Sadahira Y, Irei I, Nishimura H, Hida AI, Notohara K, Hamazaki S: Pancreatic serous microcystic adenoma with extensive oncocytic change. Pathol Int; 2009 Feb;59(2):102-6
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  • [Title] Pancreatic serous microcystic adenoma with extensive oncocytic change.
  • Herein is reported a case of pancreatic serous microcystic adenoma with extensive oncocytic change in a 73-year-old woman.
  • These cysts were lined with uniform cells having abundant eosinophilic granular cytoplasm, which was negatively or weakly stained with PAS.
  • Immunohistochemically, the cyst-lining cells were positive for cytokeratin (CK) 7, CK19, MUC1, MUC6, alpha-inhibin, and neuron-specific enolase (NSE), and negative for CK8, CK20, MUC2, and MUC5AC; these immunoprofiles coincide with those of serous microcystic adenoma.
  • Thus, this case is considered a variant of serous microcystic adenoma characterized by extensive oncocytic change.
  • [MeSH-major] Adenoma / pathology. Adenoma, Oxyphilic / pathology. Oxyphil Cells / pathology. Pancreatic Neoplasms / pathology


17. Bujas T, Pavić I, Lenicek T, Mijić A, Kruslin B, Tomas D: Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia. Acta Dermatovenerol Croat; 2007;15(3):148-51

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  • [Title] Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia.
  • A case of a 79-year-old woman with axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia is presented.
  • The cells contained abundant eosinophilic, finely granular cytoplasm with pleomorphic nuclei and showed apocrine-like decapitation.
  • The cytoplasm contained periodic acid Schiff diastase resistant granules.
  • In one area, the tumor was lobular and composed of tubular structures lined with one layer of uniform cuboidal or columnar eosinophilic cells, indicating a pre-existing apocrine adenoma.
  • This and previously reported cases suggest that apocrine hyperplasia and apocrine adenoma may represent successive steps in the development of apocrine carcinoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Apocrine Glands / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17868540.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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18. Ishida M, Hotta M, Kushima R, Tsuruoka S, Ohji M, Okabe H: Case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. Rinsho Byori; 2009 Aug;57(8):746-51
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  • [Title] Case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland.
  • Ductal adenocarcinoma of the lacrimal gland is extremely rare; to our knowledge, only seven de novo cases and one case of ductal adenocarcinoma ex pleomorphic adenoma have been reported in the literature.
  • Here, we report a case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland.
  • A 70-year-old Japanese female received the resection of the recurrent lacrimal gland tumor (second surgery), under the clinical diagnosis of recurrent pleomorphic adenoma, fifteen years after the initial surgical resection.
  • The resected tumor was composed of recurrent pleomorphic adenoma and adenocarcinoma.
  • Adenocarcinoma component showed infiltrative papillo-tubular or microcystic growth of carcinoma cells, which had pleomorphic large nuclei with prominent nucleoli and rich eosinophilic cytoplasm.
  • Accordingly, the diagnosis of ductal adenocarcinoma ex pleomorphic adenoma was made.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Ductal, Breast / pathology. Eye Neoplasms / diagnosis. Eye Neoplasms / pathology. Lacrimal Apparatus. Neoplasms, Multiple Primary

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  • (PMID = 19764409.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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19. Kunju LP: Nephrogenic adenoma: report of a case and review of morphologic mimics. Arch Pathol Lab Med; 2010 Oct;134(10):1455-9
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  • [Title] Nephrogenic adenoma: report of a case and review of morphologic mimics.
  • Nephrogenic adenoma, also referred to as nephrogenic metaplasia, is an uncommon benign lesion of the urothelial tract, characterized by a circumscribed proliferation of tubules, cysts, and papillae lined by cells with low cuboidal to columnar epithelium.
  • The diagnostic features that are useful in the recognition of this benign entity are the characteristic mixture of various architectural patterns, associated stromal edema and inflammation, hyaline sheath around tubules, eosinophilic colloidlike secretion within tubules, and lack of mitotic activity.
  • Nephrogenic adenoma can be a significant diagnostic pitfall as certain histologic features, such as the presence of enlarged nuclei with prominent nucleoli, degenerative nuclear atypia, tiny tubules with blue mucin simulating signet ring cells, and focal invasion into superficial muscle, when taken out of context, can mimic malignancy.
  • Herein, I report a case of nephrogenic adenoma with some worrisome histologic features and review the diagnostic criteria as well as pertinent morphologic malignant mimics of nephrogenic adenoma.
  • [MeSH-major] Adenoma / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 20923300.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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20. Hsiao HP, Chao MC, Lin CY, Chen HL, Chiou SS, Chen BH: Feminizing adrenocortical adenoma presenting as heterosexual precocious puberty: report of one case. Acta Paediatr Taiwan; 2005 Mar-Apr;46(2):97-100
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  • [Title] Feminizing adrenocortical adenoma presenting as heterosexual precocious puberty: report of one case.
  • We report on a case of a 2 2/12-year-old boy with heterosexual precocious puberty secondary to a feminizing adrenocortical adenoma.
  • The boy, with no previous history of disease or treatment, presented with bilateral gynecomastia and pubic hair development (Tanner III breasts and Tanner II pubic hair).
  • The pathology of the tumor showed compact pattern with polygonal cells containing moderate eosinophilic cytoplasm without mitotic figure.
  • These findings were consistent with an adrenocortical adenoma secreting estradiol and testosterone as the cause of the patient's heterosexual precocious puberty.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Puberty, Precocious / etiology

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  • [ErratumIn] Acta Paediatr Taiwan. 2005 Nov-Dec;46(6):392. Chen, Shiu-Lin [corrected to Chen, Hsiu-Lin]
  • (PMID = 16302588.001).
  • [ISSN] 1608-8115
  • [Journal-full-title] Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi
  • [ISO-abbreviation] Acta Paediatr Taiwan
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 3XMK78S47O / Testosterone; 4TI98Z838E / Estradiol
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21. Harada O, Ota H, Katsuyama T, Hidaka E, Ishizaka K, Nakayama J: Esophageal gland duct adenoma: immunohistochemical comparison with the normal esophageal gland and ultrastractural analysis. Am J Surg Pathol; 2007 Mar;31(3):469-75
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  • [Title] Esophageal gland duct adenoma: immunohistochemical comparison with the normal esophageal gland and ultrastractural analysis.
  • Esophageal gland duct adenomas are extremely rare tumors.
  • Esophageal gland duct adenoma was incidentally found in the lower esophagus.
  • Histologic analysis revealed papillary and cystic structures mainly comprising eosinophilic cells with minimum nuclear atypia.
  • Immunohistochemical analysis revealed that the tumor were diffusely positive for the S100 protein with preserved alpha-SMA-positive myoepithelial cell layers and a characteristic cytokeratin expression pattern similar to that in normal esophageal gland ducts (CK5/6+++, CK7+++, CK17+, CK18+, CK19+++, CK20-, HMWCK+++).
  • This is the first report that refers to the ultrastructural findings of an esophageal gland duct adenoma and describes terminal duct differentiation.
  • We believe that the possibility of an esophageal gland duct adenoma should be considered when diagnosing a ductal or glandular lesion of the esophagus.
  • [MeSH-major] Adenoma / pathology. Esophageal Neoplasms / pathology. Esophagus / pathology

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  • (PMID = 17325490.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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22. Ohta Y, Shiokawa A, Suzuki T, Kojima M: Cytology, immunohistochemistry and 3-dimensional reconstruction of adenoma malignum: a case report. Acta Cytol; 2005 Mar-Apr;49(2):181-6
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  • [Title] Cytology, immunohistochemistry and 3-dimensional reconstruction of adenoma malignum: a case report.
  • BACKGROUND: Cytologic diagnosis of adenoma malignum is not easy.
  • A case of adenoma malignum was diagnosed cytologically.
  • CASE: A 45-year-old woman was suspected of having adenoma malignum.
  • Cytologic analysis detected tumor cells with increased euchromatin and stretched nuclear membranes with distinct eosinophilic nucleoli.
  • In the adenoma malignum there were large and small glands showing a cumuliform pattern, and cystic dilation with discontinuity and fusion of glands could be seen.
  • CONCLUSION: The nuclear findings mentioned above were thought to be diagnostic characteristics of adenoma malignum.
  • Three-dimensional reconstruction seems to be a method that can aid in the diagnosis of adenoma malignum.

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  • (PMID = 15839625.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen
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23. Makino K, Kojima R, Nakamura H, Morioka M, Iyama K, Shigematsu K, Kuratsu J: Ectopic adrenal cortical adenoma in the spinal region: case report and review of the literature. Brain Tumor Pathol; 2010 Oct;27(2):121-5
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  • [Title] Ectopic adrenal cortical adenoma in the spinal region: case report and review of the literature.
  • Histology disclosed that the lesions were composed of sheets and nests of round and polygonal cells with mostly round regular nuclei; eosinophilic to clear cytoplasm was abundant.
  • This case confirms the occurrence of adrenocortical adenoma in the CNS.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 21046315.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Steroidogenic Factor 1; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins
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24. Reese SA, Traverso LW, Jacobs TW, Longnecker DS: Solid serous adenoma of the pancreas: a rare variant within the family of pancreatic serous cystic neoplasms. Pancreas; 2006 Jul;33(1):96-9
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  • [Title] Solid serous adenoma of the pancreas: a rare variant within the family of pancreatic serous cystic neoplasms.
  • We report the third case of a solid serous adenoma of the pancreas, a rare variant of tumor within the family of pancreatic serous cystic neoplasms.
  • Histological examination demonstrated a neoplasm identical to a serous cystadenoma-glycogen-rich cuboidal or polygonal cells with finely granulated eosinophilic or clear cytoplasm.
  • Periodic acid Schiff's-glycogen staining was positive in some cells, turning negative after diastase was applied.
  • The microscopic findings of a solid neoplasm of cuboidal cells rich in glycogen and the immunostaining listed associate this tumor with the previously 2 reported cases of solid serous adenoma.
  • Because clinical follow-up is reported only in the present case, caution should be exercised in declaring the solid serous adenoma of the pancreas as a benign lesion.

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  • (PMID = 16804417.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Kazakov DV, Mukensnabl P, Michal M: Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases. Am J Dermatopathol; 2006 Apr;28(2):142-6
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  • [Title] Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases.
  • The main controversies regarding tubular apocrine adenoma and papillary eccrine adenoma are whether they are two distinct entities or are the very same tumor, and if so, which lineage of differentiation (apocrine versus eccrine) it pursues.
  • We report two cases of tubular adenoma with follicular and, in one case, additionally, sebaceous differentiation.
  • The histologic features that both cases had in common included the combination of a tubular adenoma, foci of follicular differentiation, and areas of immature squamous metaplasia.
  • Many minute lumens surrounded by more eosinophilic cells were seen within the strands.
  • In conclusion, these two cases of cutaneous tubular adenoma with accompanying follicular and sebaceous differentiation give further support to the proposition that the majority of these neoplasms have apocrine differentiation.
  • [MeSH-major] Adenoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Back. Cell Differentiation. Cell Lineage. Eosinophils / pathology. Epithelial Cells / pathology. Epithelium / pathology. Female. Fibroblasts / pathology. Follow-Up Studies. Hair Follicle / pathology. Head and Neck Neoplasms / pathology. Humans. Middle Aged. Scalp / pathology. Sebaceous Glands / pathology

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  • (PMID = 16625077.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Piana S, Asioli S, Foroni M: Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features. Virchows Arch; 2006 Feb;448(2):228-31
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  • [Title] Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features.
  • We describe a case of oncocytic adenocarcinoma of the rectum, associated with a villous adenoma, arising on a 66-year-old man.
  • On histological examination, the adenocarcinoma was composed of neoplastic glands lined by a strongly eosinophilic, granular epithelium that deeply infiltrated the rectal wall.
  • Some basophilic calcifications were present in the gland lumina.
  • Superficially, a villous adenoma with high-grade dysplasia was evident; adenomatous cells showed focal eosinophilic changes, consisting of a large granular cytoplasm, an oval atypical nucleus, and a prominent nucleolus.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16450120.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Carcinoembryonic Antigen; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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27. Ikeda H, Takayasu S: A growth hormone-secreting adenoma with incomplete nerve bundle formation. Neuropathology; 2008 Jun;28(3):317-21

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  • [Title] A growth hormone-secreting adenoma with incomplete nerve bundle formation.
  • We present a unique case of an adenoma secreting growth hormone (GH), showing incomplete nerve bundle formation without ganglion cells.
  • Histology revealed an unusual pituitary adenoma containing many nerve bundle-like structures.
  • Adenoma cells with ovoid or round hyperchromatic nuclei and eosinophilic cytoplasms lacked the typical features of ganglion cells.
  • By immunohistochemistry, many adenoma cells were positive for GH, prolactin, thyrotropin beta, synaptophysin and chromogranin.
  • Fibrous bodies revealed by keratin immunostaining were found only in adenoma cells.
  • Scattered star-shaped adenoma cells showed the same immunoreactivity as folliculo-satellite cells.
  • Adenoma cells, but not the bundle-like structures, were also positive for Pit-1.
  • Our case is the first GH-secreting pituitary adenoma showing incomplete nerve bundle differentiation and lacking mature ganglion cells.
  • [MeSH-major] Adenoma / pathology. Growth Hormone-Secreting Pituitary Adenoma / pathology. Neurons / pathology

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  • (PMID = 18194142.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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28. Weinreb I, Simpson RH, Skálová A, Perez-Ordoñez B, Dardick I, Chetty R, Hunt JL: Ductal adenomas of salivary gland showing features of striated duct differentiation ('striated duct adenoma'): a report of six cases. Histopathology; 2010 Nov;57(5):707-15
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  • [Title] Ductal adenomas of salivary gland showing features of striated duct differentiation ('striated duct adenoma'): a report of six cases.
  • AIMS: To describe a salivary adenoma composed largely of unilayered ducts resembling striated ducts, and to differentiate it from similar adenomas, including canalicular and intercalated duct adenoma.
  • METHODS AND RESULTS: Six unilayered ductal adenomas were identified in parotid (four) and palate (two).
  • The cells were eosinophilic and bland.
  • The typical epithelial 'beading' pattern with abundant stroma of canalicular adenoma was absent.
  • CONCLUSIONS: Striated duct adenomas are unilayered ductal tumours that recapitulate normal striated ducts.
  • [MeSH-major] Adenoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • [Copyright] © 2010 Blackwell Publishing Limited.
  • (PMID = 21054495.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins
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29. Ke C, Deng Z, Lei T, Zhou S, Guo DS, Wan J, Wu S: Pituitary prolactin producing adenoma with ossification: a rare histological variant and review of literature. Neuropathology; 2010 Apr;30(2):165-9
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  • [Title] Pituitary prolactin producing adenoma with ossification: a rare histological variant and review of literature.
  • Pituitary adenoma with ossification is a rare histological variant.
  • Here a case of pituitary prolactin-producing adenoma with bone formation in a 21-year-old woman is described.
  • The cytoplasm of the adenoma cells was slightly eosinophilic and the myelo-adipose metaplastic foci were also found within the parenchyma.
  • Meanwhile, negative expressions of S-100, epithelial membrane antigen, GFAP and other pituitary hormones were also demonstrated.
  • As a rare histological variant of pituitary adenoma, the current case of pituitary prolactin producing adenoma with ossification is reported.
  • The bony shell structure may limit the growth of pituitary adenoma.
  • [MeSH-major] Ossification, Heterotopic / pathology. Pituitary Gland / pathology. Pituitary Neoplasms / pathology. Prolactinoma / pathology

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  • (PMID = 19737358.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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30. Pacchioni D, Volante M, Casetta G, Sapino A, Marchiò C, Bussolati G: Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case. Am J Surg Pathol; 2007 Apr;31(4):632-6
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  • [Title] Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case.
  • We herein report an unusual case of a low-grade myxoid renal epithelial neoplasm, with peculiar and previously unreported morphologic and immunohistochemical features.
  • These were lined by 2 different epithelial cell types, flat and elongated basal cells and cuboidal to spindle shaped eosinophilic luminal cells, with low-grade nuclear features and a few small nucleoli.
  • The lesion morphologically resembled a pleomorphic adenoma of the salivary gland.
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Salivary Gland Neoplasms / pathology

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  • (PMID = 17414112.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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31. Gambarotti M, Medicina D, Baronchelli C, Bercich L, Bonetti F, Facchetti F: Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. Int J Surg Pathol; 2008 Apr;16(2):218-21
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  • [Title] Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation.
  • The nodule showed the histological features of a bile duct adenoma.
  • Large eosinophilic, periodic acid-Schiff-positive diastase-resistant intracytoplasmic globules conferred a signet-ring appearance to the cells.
  • [MeSH-major] Adenoma / genetics. Bile Duct Neoplasms / genetics. Bile Ducts, Intrahepatic. Mutation. alpha 1-Antitrypsin / genetics

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  • (PMID = 18417685.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha 1-Antitrypsin
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32. Tuppurainen K, Mäkinen JM, Junttila O, Liakka A, Kyllönen AP, Tuominen H, Karttunen TJ, Mäkinen MJ: Morphology and microsatellite instability in sporadic serrated and non-serrated colorectal cancer. J Pathol; 2005 Nov;207(3):285-94
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  • Colorectal serrated adenocarcinoma originates from serrated adenoma, but definite histological criteria have not yet been established.
  • Serrated carcinomas frequently showed a serrated, mucinous or trabecular growth pattern; abundant eosinophilic cytoplasm; chromatin condensation; preserved polarity; and the absence of necrosis.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma / genetics. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Base Pair Mismatch / genetics. Biomarkers, Tumor / genetics. Carrier Proteins / genetics. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Colon / pathology. DNA, Neoplasm / genetics. Eosinophils / pathology. Female. Humans. Immunohistochemistry / methods. Male. Middle Aged. Neoplasm Proteins / genetics. Nuclear Proteins / genetics. Observer Variation. Rectum / pathology

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  • [Copyright] Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 16177963.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins
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33. Xu L, Zhong F, Guo FF, Zhao WJ, Sun XR, Wei XF: [Expression of motilin and its precursor mRNA in normal parenchyma, benign and malignant tumors of human thyroid]. Zhonghua Bing Li Xue Za Zhi; 2008 Apr;37(4):243-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Real-time PCR and immunohistochemical techniques were used to quantify motilin precursor mRNA and motilin peptide in thyroid tissue samples including adenoma, medullary carcinoma, follicular carcinoma, papillary carcinoma and nodular goiter. RESULTS:.
  • Thyroid tumors (acidophilic adenoma, medullary carcinoma, follicular carcinoma, papillary carcinoma and nodular goiter) showed intense and diffuse immunostaining for motilin peptide.
  • Moreover, the expression of motilin and its precursor mRNA in thyroid medullar carcinoma and acidophilic adenoma were significantly higher than those of normal thyroid tissue (P < 0.05).
  • The expressions of both motilin and its precursor mRNA in thyroid medullary carcinoma and acidophilic adenoma are significantly increased.
  • Motilin may be involved in the pathogenesis of medullary carcinoma and acidophilic adenoma of the thyroid.
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adult. Aged. Carcinoma, Medullary / genetics. Carcinoma, Papillary / genetics. Carcinoma, Papillary / metabolism. Female. Humans. Intestines / metabolism. Male. Middle Aged. Nervous System Neoplasms / metabolism. Thyroid Gland / metabolism

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  • (PMID = 18844033.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA Precursors; 0 / RNA, Messenger; 52906-92-0 / Motilin
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34. Sokolova IA, Hes O, Michal M, Matsko DE: [Small-cell variant of renal oncocytoma]. Arkh Patol; 2007 Sep-Oct;69(5):34-6
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  • This neoplasm is easily recognizable in its classic form: there are polygonal cells with abundant granular eosinophilic cytoplasm filled with mitochondria.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Small Cell / pathology. Cytoplasm / pathology. Kidney Neoplasms / pathology. Mitochondria / pathology

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  • (PMID = 18074818.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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35. Pulitzer M, Xu R, Suriawinata AA, Waye JD, Harpaz N: Microcarcinoids in large intestinal adenomas. Am J Surg Pathol; 2006 Dec;30(12):1531-6
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  • [Title] Microcarcinoids in large intestinal adenomas.
  • Composite adenoma-carcinoid tumors are rare colorectal lesions consisting of intermingled adenomatous and carcinoid components.
  • We present 4 cases of colonic adenomas containing microcarcinoids, a hitherto undescribed lesion that is either a precursor of composite adenoma-carcinoids or a related but independent entity.
  • Histologically, they consisted of collections of low-grade epithelial cells arranged in nests, cords, tubules, and irregular clusters and characterized by eosinophilic, granular, or clear cytoplasm and by round central nuclei with stippled or dusty chromatin.
  • Awareness of microcarcinoids in colonic adenomas should help avert potential diagnostic pitfalls posed by their pleomorphism, basal location, and infiltrative patterns, and may help clarify their natural history and possible relationship to composite glandular-carcinoid tumors.
  • [MeSH-major] Adenoma / pathology. Carcinoid Tumor / pathology. Intestinal Neoplasms / pathology. Intestine, Large / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17122508.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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36. Burrah R, Kini U, Correa M, Srirangapatna S: Pulmonary oncocytoma: a rare case. Asian Cardiovasc Thorac Ann; 2006 Dec;14(6):e113-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Oncocytomas are rare tumors with characteristic histological features of large eosinophilic cells with prominent nucleoli and small round nuclei.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Lung Neoplasms / pathology

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  • (PMID = 17130314.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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37. Aslam MI, Spencer L, Garcea G, Pollard C, Metcalfe MS, Harrison RF, Dennison AR: A case of liver metastasis from an oncocytoma with a focal area of chromophobe renal cell carcinoma: a wolf in sheep's clothing. Int J Surg Pathol; 2009 Apr;17(2):158-62
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  • There are reports of subtypes of renal tumors, with similar histological morphology to oncocytoma, but with malignant potential, one of these tumors is the eosinophilic variant of chromophobe renal cell carcinoma.
  • A rare case of a liver metastasis from a focal area of eosinophilic variant of chromophobe renal cell carcinoma mixed in oncocytoma in a 69-year-old woman is reported.
  • Although some renal tumors may contain oncocytoma and eosinophilic variant of chromophobe renal cell carcinoma histology, caution should be exercised while diagnosing oncocytomas in needle biopsies as there may be unsampled area of chromophobe carcinoma which has a potential for metastatic spread representing a wolf in sheep's clothing.
  • [MeSH-major] Adenoma, Oxyphilic / secondary. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Liver Neoplasms / secondary


38. Hornsby CD, Cohen C, Amin MB, Picken MM, Lawson D, Yin-Goen Q, Young AN: Claudin-7 immunohistochemistry in renal tumors: a candidate marker for chromophobe renal cell carcinoma identified by gene expression profiling. Arch Pathol Lab Med; 2007 Oct;131(10):1541-6
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  • CONTEXT: The differential diagnosis of eosinophilic renal tumors can be difficult by light microscopy.
  • Furthermore, chromophobe RCC has distinct malignant potential and prognosis compared with eosinophilic variants of other RCC subtypes.
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Claudins. Diagnosis, Differential. Immunohistochemistry. RNA, Messenger / metabolism. RNA, Neoplasm / analysis

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  • (PMID = 17922590.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1 U54 CA119338-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN7 protein, human; 0 / Claudins; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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39. Badmus TA, Adesunkanmi AR, Agbakwuru CA, Salako AA, Uhunmwagho O, Eziyi AK: Giant renal oncocytoma masquerading as infiltrating renal cell carcinoma: case report and literature review. Cent Afr J Med; 2006 Jan-Feb;52(1-2):16-9
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  • Renal oncocytomas (RO) are tumours containing a population of cells with highly differentiated eosinophilic granular cytoplasm, extremely rich in mitochondria.
  • In view of the difficulties at establishing pre-operative diagnosis in this disease and because nephron-sparing surgery is curative, especially for the well-circumscribed tumours, RO should be considered in the management of patients with features of infiltrating RCC.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 17892235.001).
  • [ISSN] 0008-9176
  • [Journal-full-title] The Central African journal of medicine
  • [ISO-abbreviation] Cent Afr J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Zimbabwe
  • [Number-of-references] 37
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40. Coburn V, Radfar A, Snook D, Mahalingam M: Cutaneous oncocytoma - a report of three cases and review of the literature. J Cutan Pathol; 2007 Apr;34(4):355-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The oncocyte is a cell characterized by capacious, eosinophilic, finely granular cytoplasm, and lesions composed primarily of oncocytes are termed oncocytomas.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Skin Neoplasms / pathology

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  • (PMID = 17381809.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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41. Huang W, Kanehira K, Drew S, Pier T: Oncocytoma can be differentiated from its renal cell carcinoma mimics by a panel of markers: an automated tissue microarray study. Appl Immunohistochem Mol Morphol; 2009 Jan;17(1):12-7
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  • RESULT: EABA was positive in 97% of oncocytoma, 26% of conventional RCC and 35% of papillary RCC with granular/eosinophilic (G/E) features and 6% of chromophobe RCC.

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  • (PMID = 18769342.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Vimentin; EC 2.7.11.22 / MOK protein, human; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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42. Mete O, Kilicaslan I, Gulluoglu MG, Uysal V: Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis. Virchows Arch; 2005 Dec;447(6):938-46
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  • Among the epithelial renal tumours with eosinophilic cytoplasm, the main differential diagnostic problem arises between renal oncocytomas (ROs) and eosinophilic variants of chromophobe renal cell carcinomas (RCCs).
  • We investigated the possible role of anti-mitochondrial (AMA), anti-caveolin 1 (CAV1), anti-CD63 (CD63) and anti-cytokeratin 14 (CK14) antibodies in the differential diagnosis of eosinophilic epithelial tumours and applied the Muller and Mowry modification of Hale's colloidal iron stain (HCI).
  • Thirty-five ROs and 77 eosinophilic RCCs (27 chromophobe, 28 clear cell and 22 papillary RCCs) were included in this study.
  • Apical and/or polar CD63 immunostaining (94%) and diffuse AMA (91%) and CAV1 (88%) immunostainings were the characteristics of ROs, whereas diffuse CD63 immunostaining (96%) and diffuse-peripheral AMA (96%) and CAV1 (92%) immunostainings were characteristic immunohistochemical features of eosinophilic chromophobe RCCs.
  • We showed CK14 antibody not to be useful in the differential diagnosis of the eosinophilic epithelial renal tumours.
  • We recommend using CD63 as the best marker of choice for distinguishing ROs from eosinophilic chromophobe RCCs when standard diagnostic criteria are not helpful.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Biomarkers, Tumor / analysis. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology

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  • (PMID = 16133362.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD63; 0 / Biomarkers, Tumor; 0 / CD63 protein, human; 0 / Platelet Membrane Glycoproteins; 68238-35-7 / Keratins
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43. Angulo J, Jaqueti G, Kutzner H, Requena L: Squamous cell apocrine hidradenoma. J Cutan Pathol; 2007 Oct;34(10):801-3

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  • These squamous cells showed large eosinophilic cytoplasm and vesicular nuclei with prominent nucleoli.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Squamous Cell / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17880588.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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44. Fracassi F, Gandini G, Diana A, Preziosi R, Ingh TS, Famigli-Bergamini P, Kooistra HS: Acromegaly due to a somatroph adenoma in a dog. Domest Anim Endocrinol; 2007 Jan;32(1):43-54
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  • [Title] Acromegaly due to a somatroph adenoma in a dog.
  • CT scanning of the skull showed an enlarged pituitary gland with normal enhancement pattern.
  • The pituitary gland contained an acidophilic adenoma that immunostained positively for GH (and negatively for ACTH and alpha-MSH).
  • In conclusion, this Dalmatian dog with acromegaly and insulin resistance represents the first case of GH hypersecretion proven to be due to a somatotroph adenoma.
  • [MeSH-major] Acromegaly / veterinary. Adenoma / veterinary. Dog Diseases / pathology. Pituitary Neoplasms / veterinary

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  • (PMID = 16472961.001).
  • [ISSN] 0739-7240
  • [Journal-full-title] Domestic animal endocrinology
  • [ISO-abbreviation] Domest. Anim. Endocrinol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-72-6 / Growth Hormone
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45. Samaila MO: Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med; 2008 Mar;7(1):6-10

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  • All tissue specimens were fixed in 10% formalin, processed in paraffin wax and stained with Haematoxylin and Eosin.
  • Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas.
  • Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma.
  • The commonest variants are those of eccrine sweat gland origin.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / pathology. Adenoma, Sweat Gland / epidemiology. Adenoma, Sweat Gland / pathology. Adolescent. Adult. Aged. Child. Child, Preschool. Female. Hair Follicle / pathology. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / pathology. Humans. Infant, Newborn. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / pathology. Sweat Gland Neoplasms / epidemiology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18702242.001).
  • [ISSN] 1596-3519
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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46. Svajdler M, Bohus P, Goc V, Tkácová V: [Perivascular epithelioid cell tumor (PEComa) of the liver: a case report and review of the literature]. Cesk Patol; 2007 Jan;43(1):18-22
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  • [Transliterated title] Perivascular epithelioid cell tumor (PEComa) pecene: popis prípadu a prehl'ad literatúry.
  • Histologically the tumor grew in expansive way, and was composed of clear and eosinophilic epithelioid cels, without vascular or lipomatous component characteristic of angiomyolipoma.
  • The main differential diagnosis of hepatic PEComa includes clear cell variant of liver cell adenoma and hepatocellular carcinoma, metastases of various clear cell carcinomas and metastasis of malignant melanoma.


47. Ide F, Obara K, Enatsu K, Mishima K, Saito I: Sclerosing mucoepidermoid carcinoma of the oral cavity. J Oral Pathol Med; 2005 Mar;34(3):187-9
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  • SMEC involvement of salivary gland is exceptional, with only six cases in the literature.
  • A particularly interesting finding is the cytoplasmic accumulation of eosinophilic hyaline granules in carcinoma cells, similar to aberrant zymogen-like granules previously described in salivary sclerosing polycystic adenosis.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Gingival Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenoma / pathology. Adult. Cytoplasm / ultrastructure. Eosinophils / pathology. Humans. Hyalin / ultrastructure. Male. Sclerosis. Secretory Vesicles / ultrastructure

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  • (PMID = 15689234.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 7
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48. Yamaguchi T, Kuroda N, Imamura Y, Hes O, Michal M, Sima R, Nakayama K, Sato N: Imprint cytologic features of chromophobe renal cell carcinoma morphologically resembling renal oncocytoma: is this an oncocytic variant of chromophobe renal cell carcinoma? Diagn Cytopathol; 2010 Jul;38(7):509-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologically, the cytoplasm was abundant granular eosinophilic and composed of solid cell sheets or pseudoacinar structures.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Cytological Techniques / methods. Kidney / pathology. Kidney Neoplasms / pathology


49. Wang LH, Zhao YJ, Wang XY, Yuan P, Xu WQ, Xiao JC, Xu JP, Luo BR: [Significance of galectin-3 and CD44v6 expression in differential diagnosis of thyroid nodules]. Zhonghua Zhong Liu Za Zhi; 2005 Sep;27(9):547-50
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  • RESULTS: Expression of these two markers in benign thyroid nodules: galectin-3 was negative in 10 cases of para-cancer normal tissue and 14 cases of benign nodules found in the other benign thyroid disease.
  • Also it was weakly positive in 2 of 22 follicular adenomas (9.1%).
  • But all three eosinophilic follicular adenomas were diffusely or focally positive for galectin-3.
  • It was also positive in 16 of 52 nodular goiters (30.8%), and weakly positive in 7 of 22 follicular adenomas (31.8%).
  • [MeSH-minor] Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / metabolism. Adenoma / diagnosis. Adenoma / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male

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  • (PMID = 16438854.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / CD44v6 antigen; 0 / Galectin 3; 0 / Glycoproteins
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50. Kloub O, Perry A, Tu PH, Lipper M, Lopes MB: Spindle cell oncocytoma of the adenohypophysis: report of two recurrent cases. Am J Surg Pathol; 2005 Feb;29(2):247-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recently, both underwent transsphenoidal reexploration for recurrent "pituitary adenoma."
  • He recently presented with a large mass that involved the pituitary fossa and base of the skull, with extension into the nasopharynx and nasal cavity.
  • The primary and recurrent lesions of both cases showed similar architecture with interlacing fascicles of spindle cells that alternated with areas of epithelioid-like cells that exhibited eosinophilic, granular cytoplasm.
  • Neoplastic cells were positive for vimentin, S-100 protein, and epithelial membrane antigen, and negative for glial fibrillary acidic protein, chromogranin, and pituitary hormones.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Neoplasm Recurrence, Local / pathology. Pituitary Neoplasms / pathology

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  • (PMID = 15644783.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Toxicology and carcinogenesis studies of androstenedione (CAS No. 63-05-8) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Sep;(560):1, 7-31,33-171 passim
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  • Incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined) were significantly increased in 20 mg/kg males.
  • The incidence of testicular interstitial cell adenoma (including bilateral) was significantly decreased in 50 mg/kg males.
  • In females, the incidences of mammary gland fibroadenoma were significantly decreased in the 20 and 50 mg/kg groups, the incidences of mammary gland hyperplasia were significantly decreased in all dosed groups, and the incidences of mammary gland cyst were significantly decreased in the 10 and 50 mg/kg groups.
  • In the liver of males, the incidences of basophilic focus in all dosed groups, the incidence of clear cell focus in the 20 mg/kg group, and the incidence of eosinophilic focus in the 50 mg/kg group were significantly increased.
  • The incidences of hepatocellular adenoma in males and females were significantly increased in the 50 mg/kg groups.
  • Incidences of hepatocellular adenoma or carcinoma (combined) in males and females were significantly increased in the 50 mg/kg groups.
  • Incidences of multiple hepatocellular adenomas and carcinomas were significantly increased in 10 and 50 mg/kg males, and there was an increased incidence of multiple hepatocellular adenomas in 50 mg/kg females.
  • The incidence of eosinophilic focus was significantly increased in 50 mg/kg males, and the incidences of mixed cell focus and cytoplasmic vacuolization were significantly increased in 50 mg/kg females.
  • There was a marginally increased incidence of pancreatic islet adenoma in 50 mg/kg males and in 10 and 50 mg/kg females, with an earlier day of first incidence in males.
  • The incidences of clitoral gland hyperplasia and clitoral gland duct dilatation were significantly increased in 10 and 50 mg/kg females.
  • The incidence of glomerular metaplasia of the kidney was significantly increased in 50 mg/kg females, and the incidences of cytoplasmic alteration of the submandibular salivary gland were significantly increased in all dosed female groups.
  • The increased incidences of cytoplasmic alteration of the submandibular salivary gland and glomerular metaplasia of the kidney in female mice indicated a masculinizing effect from androstenedione treatment.
  • CONCLUSIONS: under the conditions of these 2-year gavage studies, there was equivocal evidence of carcinogenic activity of androstenedione in male F344/N rats based on increased incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined).
  • There was clear evidence of carcinogenic activity of androstenedione in male B6C3F1 mice based on increased incidences of multiple hepatocellular adenoma and hepatocellular carcinoma and increased incidence of hepatoblastoma.
  • There was clear evidence of carcinogenic activity of androstenedione in female B6C3F1 mice based on increased incidences of hepatocellular adenoma and hepatocellular carcinoma.
  • Increased incidences of pancreatic islet adenoma in male and female mice were also considered chemical related.
  • Androstenedione administration caused increased incidences in nonneoplastic lesions of the liver in male and female rats and mice; pancreatic islets and exocrine pancreas of female rats; and clitoral gland, kidney, and submandibular salivary gland of female mice.
  • Decreases in the incidences of testicular interstitial cell adenoma in male rats, mammary gland fibroadenoma, cysts, and hyperplasia in female rats, and malignant lymphoma in female mice were considered related to androstenedione administration.

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  • (PMID = 21037592.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Review; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Mutagens; 409J2J96VR / Androstenedione
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52. El Demellawy D, Daya D, Alowami S: Clear cell hidradenoma: an unusual vulvar tumor. Int J Gynecol Pathol; 2008 Jul;27(3):457-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologically, it is a well-circumscribed, nonencapsulated tumor formed of 2 cell types, one with clear cytoplasm and the other with dark eosinophilic cytoplasm.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 18580328.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Abrahams NA, Tamboli P: Oncocytic renal neoplasms: diagnostic considerations. Clin Lab Med; 2005 Jun;25(2):317-39, vi
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Advances in our understanding of renal neoplasia have resulted in recognition of numerous tumors that are composed predominantly of cells with abundant eosinophilic cytoplasm.
  • This article discusses the features of renal oncocytoma (including oncocytosis), chromophobe renal cell carcinoma (RCC), and clear cell RCC; explores the relationship between renal oncocytoma and chromophobe RCC; briefly discusses other tumors with abundant eosinophilic cytoplasm; and emphasizes the differential diagnosis of such tumors.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 15848739.001).
  • [ISSN] 0272-2712
  • [Journal-full-title] Clinics in laboratory medicine
  • [ISO-abbreviation] Clin. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FLCN protein, human; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 98
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54. Sav A, Scheithauer BW, Mazzola CA, Ketterling SR, Thompson SJ, Reilly MH: Oncocytic choroid plexus carcinoma: case report. Clin Neuropathol; 2010 Jan-Feb;29(1):14-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In contrast, the large, eosinophilic, cytologically malignant but granular-appearing oncocytes comprising the majority of the lesion showed scant (1/10 HPF) mitotic activity and only a low MIB-1 labeling index (5%).
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Brain / pathology. Carcinoma / pathology. Choroid Plexus Neoplasms / pathology

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  • (PMID = 20040328.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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55. Kazakov DV, Vanecek T, Belousova IE, Mukensnabl P, Kollertova D, Michal M: Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: hidradenoma of the breast. Am J Dermatopathol; 2007 Oct;29(5):457-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The cystic component, which predominated in the lesion, was filled with homogeneous eosinophilic material.
  • [MeSH-major] Adenoma, Sweat Gland / genetics. Breast Neoplasms / genetics. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. Translocation, Genetic / genetics

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  • (PMID = 17890914.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
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56. Oku T, Maeda M, Wada Y, Waga E, Ono K, Nagamachi Y, Fujii S, Fujita M, Misu K, Senmaru N, Suzuki Y, Nagashima K, Niitsu Y: Intraductal oncocytic papillary neoplasm having clinical characteristics of mucinous cystic neoplasm and a benign histology. JOP; 2007;8(2):206-13
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  • Microscopically, the cyst was lined by columnar epithelium similar to pancreatic duct epithelium, and the nodular projection consisted of arborizing papillary structures, lined by plump cells with abundant eosinophilic cytoplasm.
  • These eosinophilic cells were immunohistochemically positively stained with anti-mitochondrial antibody.
  • The cellular atypism was mild and the proliferating index was low, compatible with adenoma of an intraductal oncocytic papillary neoplasm.

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  • (PMID = 17356245.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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57. Serra S, Asa SL, Chetty R: Intracytoplasmic inclusions (including the so-called "rhabdoid" phenotype) in pancreatic endocrine tumors. Endocr Pathol; 2006;17(1):75-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Intracytoplasmic eosinophilic inclusions can vary morphologically and the spectrum ranges from small, dot-like hyaline inclusions, to deeply acidophilic/eosinophilic ones that occupy almost the whole cytoplasm and displace the nucleus eccentrically: the so-called "rhabdoid" phenotype.
  • This study confirms that a spectrum of large intracytoplasmic inclusions is encountered in PET, ranging from lightly eosinophilic intracytoplasmic globules to the more typical rhabdoid phenotype (deeply eosinophilic inclusions).
  • [MeSH-major] Adenoma, Islet Cell / pathology. Carcinoma, Islet Cell / pathology. Inclusion Bodies / pathology. Multiple Endocrine Neoplasia Type 1 / pathology. Pancreatic Neoplasms / pathology. Rhabdoid Tumor / pathology

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  • (PMID = 16760583.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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58. Ohi Y, Umekita Y, Rai Y, Kukita T, Sagara Y, Sagara Y, Takahama T, Andou M, Sagara Y, Yoshida A, Yoshida H: Clear cell hidradenoma of the breast: a case report with review of the literature. Breast Cancer; 2007;14(3):307-11
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  • Histological examination demonstrated characteristic histological features of clear cell hidradenoma, such as proliferation of uniform epithelial cells, clear or slightly eosinophilic cytoplasm, and cuboidal cell-lined ductal structures.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Breast Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17690510.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 16
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59. Yamaguchi Y, Hoshiya T, Horiguchi K, Tamura K: An occurrence of multiple carcinomas in both kidneys of a 5-year-old female cynomolgus monkey (Macaca fascicularis). Toxicol Pathol; 2007 Dec;35(7):1010-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cytoplasm was abundant and either granular and eosinophilic or clear, and nuclei were large and vesicular with prominent nucleoli.
  • Small foci of tubular epithelial cell hyperplasia and adenomas were also observed independently of carcinomas.
  • There was no evidence of transition from adenoma to carcinoma, and no metastases were detected.

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  • (PMID = 18098046.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Lefèvre M, Couturier J, Sibony M, Bazille C, Boyer K, Callard P, Vieillefond A, Allory Y: Adult papillary renal tumor with oncocytic cells: clinicopathologic, immunohistochemical, and cytogenetic features of 10 cases. Am J Surg Pathol; 2005 Dec;29(12):1576-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • They consisted of thin, nonfibrotic papillae lined by a single layer of oncocytic cells, with finely granular eosinophilic cytoplasm and round regular nucleus exhibiting central nucleolus (Fuhrman grade II, except for one grade III).
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Papillary / pathology. Cytogenetics. Immunohistochemistry. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Follow-Up Studies. Humans. Karyotyping. Male. Middle Aged. Neoplasm Staging. Nephrectomy. Nucleic Acid Hybridization. Retrospective Studies. Time Factors. Treatment Outcome. Tumor Burden

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  • (PMID = 16327429.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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61. Dubb M, Michelow P: Cytologic features of hidradenoma in fine needle aspiration biopsies. Acta Cytol; 2009 Mar-Apr;53(2):179-82
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  • In addition, a biphasic cytoplasmic staining pattern with both eosinophilic and clear to basophilic cells may be seen with the Papanicolaou stain in hidradenomas.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19365971.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Wakely PE Jr: Oncocytic and oncocyte-like lesions of the head and neck. Ann Diagn Pathol; 2008 Jun;12(3):222-30
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  • An oncocyte is a cell containing an abundant amount of deeply eosinophilic finely granular cytoplasm, rounded nuclei, and variable presence of nucleoli in conventional hematoxylin-eosin-stained sections.
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Biopsy, Fine-Needle. Humans. Salivary Gland Neoplasms / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18486901.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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63. Kuehn A, Paner GP, Skinnider BF, Cohen C, Datta MW, Young AN, Srigley JR, Amin MB: Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications. Am J Surg Pathol; 2007 Oct;31(10):1528-33
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  • Immunoreactivity in other tumors with granular eosinophilic cytoplasm including clear cell and papillary renal cell carcinomas needs to be clearly elucidated and its expression in emerging novel and other unusual renal epithelial neoplasm subtypes including tumors with uncertain histogenesis is not yet known.
  • Reactivity with Ksp-cad was observed in the following tumors: chromophobe renal cell carcinoma [23/25 (92%), diffuse (>50% of tumor cells)] positivity and membranous characteristically accentuating the "plant cell-like" histomorphology of the typical (clear) type, renal oncocytoma [15/20 (75%), usually diffuse staining with predominantly membranous accentuation], papillary renal cell carcinoma [5/17 (29%) all focal to moderate, eosinophilic type or type 2-3/7 (43%), basophilic type or type 1-2/10 (20%)], Xp11 translocation carcinoma [1/4 (25%), diffuse positivity] and clear cell renal cell carcinoma [6/36 (17%) all focal, clear cell renal cell carcinoma with prominent eosinophilic cells 1/7 (14%)].
  • Ksp-cad may be helpful in distinguishing these two tumor types from clear cell renal cell carcinoma with prominent eosinophilic cells particularly in cases with limited tissue samples (ie, needle core biopsy).
  • In the similar diagnostic setting, caution must be exercised, however, in differentiating chromophobe renal cell carcinoma and renal oncocytoma from the eosinophilic variant of papillary renal cell carcinoma as moderate expression of Ksp-cad may be observed in papillary renal cell carcinoma.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / metabolism. Adenocarcinoma, Papillary / pathology. Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Carcinoma / metabolism. Carcinoma / pathology. Carcinoma, Medullary / metabolism. Carcinoma, Medullary / pathology. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Carcinoma, Transitional Cell / metabolism. Carcinoma, Transitional Cell / pathology. Eosinophilia / metabolism. Eosinophilia / pathology. Humans. Immunoenzyme Techniques. Immunohistochemistry / methods. Tissue Array Analysis

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  • (PMID = 17895753.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDH16 protein, human; 0 / Cadherins
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64. González-Vela MC, Val-Bernal JF, Garcia-Alberdi E, González-López MA, Fernández-Llaca JH: Trichoadenoma associated with an intradermal melanocytic nevus: a combined malformation. Am J Dermatopathol; 2007 Feb;29(1):92-5
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  • Histopathologically, multiple keratinous cysts together with solid islands or masses of eosinophilic epithelial cells were closely intermingled with the nevus cells.
  • [MeSH-major] Adenoma / pathology. Hamartoma / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 17284971.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Doughty RW, Brockman D, Neiger R, McKinney L: Nasal oncocytoma in a domestic shorthair cat. Vet Pathol; 2006 Sep;43(5):751-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologic examination from biopsy material revealed monomorphic sheets, anastomosing cords, tubules, and acini composed of large polygonal to oval cells that contained abundant finely granular eosinophilic cytoplasm.
  • Histochemical stains revealed positive staining of tumor cells with periodic acid-Schiff (PAS) (before and after diastase digestion) and phosphotungstic acid-hematoxylin.
  • [MeSH-major] Adenoma, Oxyphilic / veterinary. Cat Diseases / pathology. Nose Neoplasms / veterinary

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  • (PMID = 16966454.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Kazakov DV, Schaller J, Vanecek T, Kacerovska D, Michal M: Brooke-Spiegler syndrome: report of a case with a novel mutation in the CYLD gene and different types of somatic mutations in benign and malignant tumors. J Cutan Pathol; 2010 Aug;37(8):886-90
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  • There were also numerous signet ring cells and cells containing intracytoplasmic eosinophilic inclusions.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Basal Cell / genetics. Carcinoma, Skin Appendage / genetics. Facial Neoplasms / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 20132422.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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72. Kazakov DV, Kutzner H, Spagnolo DV, Kempf W, Zelger B, Mukensnabl P, Michal M: Sebaceous differentiation in poroid neoplasms: report of 11 cases, including a case of metaplastic carcinoma associated with apocrine poroma (sarcomatoid apocrine porocarcinoma). Am J Dermatopathol; 2008 Feb;30(1):21-6
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  • In 1 of the 3 poroid hidradenomas, the eosinophilic cuticle lining the cyst was crenulated in foci associated with sebocytes.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Multiple Primary / pathology. Sarcoma / pathology. Sebaceous Glands / pathology. Skin Neoplasms / pathology

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  • (PMID = 18212539.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Hes O, Vanecek T, Perez-Montiel DM, Alvarado Cabrero I, Hora M, Suster S, Lamovec J, Curik R, Mandys V, Michal M: Chromophobe renal cell carcinoma with microcystic and adenomatous arrangement and pigmentation--a diagnostic pitfall. Morphological, immunohistochemical, ultrastructural and molecular genetic report of 20 cases. Virchows Arch; 2005 Apr;446(4):383-93
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  • Microcystic areas were composed of smaller eosinophilic and bigger pale cells having cytological appearance typical of conventional CRCC.
  • They had a typical columnar arrangement with nuclei positioned at the base of the glandular structures and a small amount of a deeply eosinophilic cytoplasm often endowed with brush border facing the lumen of the glands.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Oxyphil Cells / ultrastructure

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  • (PMID = 15756595.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Pigments, Biological
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74. Yildiz B, Ozdemir F, Cobanoglu U, Kavgaci H, Fidan E, Aydin F: Clear cell hidradenoma of the gluteal region: a case report. Acta Dermatovenerol Croat; 2009;17(2):144-6

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  • Under the epidermis, an eosinophilic-cytoplasm, uniform-appearance, oval-round-nucleus, benign tumor with cystic and solid components was detected.
  • The patient had not been given postoperative adjuvant treatment and has been under follow up free from disease for 2 years.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Buttocks / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19595274.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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75. Lee SS, Baek KH, Lee YS, Lee JM, Kang MI, Cha BY, Lee KW, Son HY, Kang SK: Subclinical Cushing's syndrome associated with an adrenocortical oncocytoma. J Endocrinol Invest; 2008 Jul;31(7):675-9
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  • Oncocytoma is a neoplasm that can arise in several organs, and it has been more commonly described in the kidney, salivary gland and thyroid.
  • Oncocytoma arising in the adrenal gland is a rare finding.
  • The tumor consisted almost exclusively of large eosinophilic and epitheloid cells whose cytoplasm was packed with eosinophilic granulations, which corresponded to the numerous mitochondria confirmed on electron microscopy.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenal Cortex Neoplasms / pathology. Cushing Syndrome / pathology

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  • (PMID = 18787391.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Synaptophysin; 0 / inhibin A; 57285-09-3 / Inhibins; 68238-35-7 / Keratins; 7S5I7G3JQL / Dexamethasone
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76. National Toxicology Program: Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser; 2006 Aug;(530):1-258
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  • At the end of the 2-year study, there were significantly increased incidences and severities of toxic hepatopathy characterized by hepatocyte hypertrophy, multinucleated hepatocytes, pigmentation, diffuse and focal fatty change, eosinophilic focus, nodular hyperplasia, cholangiofibrosis, oval cell hyperplasia, bile duct cysts, bile duct hyperplasia, necrosis, and portal fibrosis.
  • Significantly increased incidences of hepatocellular adenoma, cholangiocarcinoma, and hepatocholangioma were observed in the study.
  • Numerous nonneoplastic effects were seen in other organs at the interim time points including atrophy of the thymus and follicular cell hypertrophy of the thyroid gland.

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  • (PMID = 17160104.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; DFC2HB4I0K / Polychlorinated Biphenyls; TSH69IA9XF / 3,4,5,3',4'-pentachlorobiphenyl; ZRU0C9E32O / 2,4,5,2',4',5'-hexachlorobiphenyl
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77. Cruz Cardona JA, Wamsley HL, Farina LL, Kiupel M: Metastatic pancreatic polypeptide-secreting islet cell tumor in a dog. Vet Clin Pathol; 2010 Sep;39(3):371-6
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  • Cytologic examination of the enlarged lymph nodes revealed loosely cohesive cells with moderate nuclear pleomorphism and rare punctate eosinophilic cytoplasmic granules.

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  • [Copyright] ©2010 American Society for Veterinary Clinical Pathology.
  • (PMID = 20698942.001).
  • [ISSN] 1939-165X
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 59763-91-6 / Pancreatic Polypeptide
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78. Hes O, Brunelli M, Michal M, Cossu Rocca P, Hora M, Chilosi M, Mina M, Boudova L, Menestrina F, Martignoni G: Oncocytic papillary renal cell carcinoma: a clinicopathologic, immunohistochemical, ultrastructural, and interphase cytogenetic study of 12 cases. Ann Diagn Pathol; 2006 Jun;10(3):133-9
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  • Papillary renal cell carcinoma (RCC) is subclassified in type 1 displaying cells with scanty pale cytoplasm arranged in a single layer and in type 2 showing pseudostratified cells with eosinophilic cytoplasm.
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Adult. Aged. Aged, 80 and over. Aneuploidy. Biomarkers, Tumor / analysis. Chromosome Deletion. Chromosomes, Human, Pair 17. Chromosomes, Human, Pair 7. Chromosomes, Human, Y / genetics. Cytoplasm / ultrastructure. Diagnosis, Differential. Female. Humans. In Situ Hybridization, Fluorescence. Interphase / genetics. Male. Middle Aged


79. Archondakis S, Skagias L, Tsakiris A, Sambaziotis D, Daskalopoulou D: Oncocytoma of the lacrimal gland diagnosed initially by fine-needle aspiration cytology. Diagn Cytopathol; 2009 Jun;37(6):443-5

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  • [Title] Oncocytoma of the lacrimal gland diagnosed initially by fine-needle aspiration cytology.
  • We describe a case of oncocytoma of the lacrimal gland which was initially diagnosed by fine-needle aspiration cytology.
  • The cytoplasm of the tumor cells was rich in eosinophilic granules.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Lacrimal Apparatus / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19217061.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Sugihara A, Nakasho K, Ikuta S, Aihara T, Kawai T, Iida H, Yoshie H, Yasui C, Mitsunobu M, Kishi K, Mori T, Yamada N, Yamanegi K, Ohyama H, Terada N, Ohike N, Morohoshi T, Yamanaka N: Oncocytic non-functioning endocrine tumor of the pancreas. Pathol Int; 2006 Dec;56(12):755-9
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  • Tumor cells were arranged in a ribbon-like or trabecular pattern and had an abundant eosinophilic cytoplasm containing numerous mitochondria and neurosecretory granules.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17096734.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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81. Brocks BA, Peeters ME, Kimpfler S: Oncocytoma in the mandibular salivary gland of a cat. J Feline Med Surg; 2008 Apr;10(2):188-91
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  • [Title] Oncocytoma in the mandibular salivary gland of a cat.
  • Initial investigations suggested a malignant salivary gland tumour, and the mass was removed by extracapsular resection of the mandibular gland.
  • Histopathology showed an oncocytoma within the salivary gland.
  • Oncocytes are cells with a small nucleus and intense eosinophilic granular cytoplasm due to numerous mitochondria, which proliferate during ageing in exocrine and endocrine glandular tissues.
  • This is the first report of an oncocytoma in a feline mandibular salivary gland, and the first report of long-term survival after surgical removal.
  • [MeSH-major] Adenoma, Oxyphilic / veterinary. Cat Diseases / diagnosis. Salivary Gland Neoplasms / veterinary

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  • (PMID = 18160323.001).
  • [ISSN] 1098-612X
  • [Journal-full-title] Journal of feline medicine and surgery
  • [ISO-abbreviation] J. Feline Med. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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82. Deshpande A, Munshi M: Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report. Indian J Pathol Microbiol; 2005 Apr;48(2):230-5
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  • Smears showed polygonal or rounded cells in groups and acinar pattern having a well-defined, granular, eosinophilic cytoplasm, and round regular nuclei displaying very little pleomorphism.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology

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  • (PMID = 16758678.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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83. Cuadra Zelaya F, Quezada Rivera D, Tapia Vazquez JL, Paez Valencia C, Gaitán Cepeda LA: Plasmacytoid myoepithelioma of the palate. Report of one case and review of the literature. Med Oral Patol Oral Cir Bucal; 2007 Dec;12(8):E552-5

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  • Microscopically, the lesion was composed by myoepithelial neoplastic cells characterized by a round ovoid silhouette, an eccentric nuclei of dense chromatin and eosinophilic cytoplasm.
  • The histological diagnostic parameters of plasmacytoid myoepithelioma versus pleomorphic adenoma are discussed.

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  • (PMID = 18059237.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 16
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84. Kazakov DV, Magro G, Kutzner H, Spagnolo DV, Yang Y, Zaspa O, Mukensnabl P, Michal M: Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: a clinicopathological study of 6 cases. Am J Dermatopathol; 2008 Oct;30(5):436-41

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  • This consisted of compactly situated, well-developed glands having small round lumens lined by inner pale to eosinophilic cells and surrounded by an outer well-formed peripheral layer of myoepithelial cells, which reacted with a variety of myoepithelial cell markers.
  • [MeSH-major] Adenoma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18806484.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-14
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85. Matyja E, Maksymowicz M, Grajkowska W, Olszewski W, Zieliński G, Bonicki W: Spindle cell oncocytoma of the adenohypophysis - a clinicopathological and ultrastructural study of two cases. Folia Neuropathol; 2010;48(3):175-84
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  • Spindle cell oncocytoma (SCO) of the pituitary gland is a relatively recently established, very rare subtype of adenohypophysis tumours that was introduced as a distinct clinicopathological entity in the fourth edition of WHO classification of the central nervous system tumours (2007).
  • It is non-endocrine neoplasm of the anterior pituitary that occurs in adults and usually follows a benign clinical course, corresponding to WHO grade I.
  • Up to now, pituitary SCO have been reported occasionally and only 14 cases of SCO have been documented in the literature.
  • The clinical and radiological features suggested non-functioning pituitary macroadenomas without evidence of invasive growth.
  • Histologically and immunohistochemically, both tumours displayed the features typical for SCO of the pituitary.
  • They were composed of interwoven fascicles of spindle cells exhibiting abundant eosinophilic cytoplasm of oncocytic or granular appearance.
  • The tumour cells exhibited immunoreactivity for S-100 protein, galectin-3, vimentin and epithelial membrane antigen but they were negative for GFAP, anterior pituitary neuroendocrine markers (prolactin, growth hormone, TSH, ACTH, FSH, LH), chromogranin, synaptophysin, cytokeratin CK (AE1/AE3), smooth muscle actin, desmin, CD34 and CD68.
  • Spindle cell oncocytoma of the anterior pituitary is often misdiagnosed entity of uncertain histogenesis.

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  • (PMID = 20925001.001).
  • [ISSN] 1509-572X
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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86. Zhou CX, Shi DY, Ma DQ, Zhang JG, Yu GY, Gao Y: Primary oncocytic carcinoma of the salivary glands: a clinicopathologic and immunohistochemical study of 12 cases. Oral Oncol; 2010 Oct;46(10):773-8
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  • Oncocytic carcinoma (OC) of salivary gland origin is an extremely rare proliferation of malignant oncocytes with adenocarcinomatous architectural phenotypes, including infiltrative qualities.
  • Most occurred in the parotid gland (10/12) with one in the palate and one in the retromolar gland.
  • The tumors were unencapsulated and often invaded into the nearby gland, lymphatic tissues and nerves.
  • The neoplastic cells had eosinophilic granular cytoplasm and round vesicular nuclei with prominent red nucleoli.
  • Five-year disease-specific survivals were 54.9%.
  • In summary, OC of salivary gland origin is a high-grade tumor, often with local recurrence, regional or distant metastasis, diagnosis of which based on a combination of clinical and histopathological features.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Oxyphil Cells / pathology. Salivary Gland Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20843731.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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87. Irving JA, Young RH: Microcystic stromal tumor of the ovary: report of 16 cases of a hitherto uncharacterized distinctive ovarian neoplasm. Am J Surg Pathol; 2009 Mar;33(3):367-75
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  • The cells contained moderately conspicuous finely granular, lightly eosinophilic cytoplasm, with generally bland, round to oval or spindle-shaped nuclei with fine chromatin and small indistinct nucleoli.
  • For tumors which have been well sampled and exhibit (1) a microcystic pattern and regions with lobulated cellular masses with intervening, sometimes hyalinized fibrous stroma, (2) an absence of morphologic features enabling any other specific diagnosis in the sex cord-stromal category, (3) an absence of epithelial elements, and (4) an absence of teratomatous or other germ cell elements, we propose the designation "microcystic stromal tumor."
  • Seven patients with available follow-up are without evidence of disease at a mean of 4.25 years (range: 1.5 to 12.5 y) from the time of initial diagnosis.
  • [MeSH-major] Adenoma / classification. Adenoma / pathology. Ovarian Neoplasms / classification. Ovarian Neoplasms / pathology. Stromal Cells / pathology

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  • (PMID = 18971779.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Hes O, Síma R, Nemcová J, Hora M, Bulimbasic S, Kazakov DV, Urge T, Reischig T, Dvorák M, Michal M: End-stage kidney disease: gains of chromosomes 7 and 17 and loss of Y chromosome in non-neoplastic tissue. Virchows Arch; 2008 Oct;453(4):313-9
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  • [Title] End-stage kidney disease: gains of chromosomes 7 and 17 and loss of Y chromosome in non-neoplastic tissue.
  • The aim of this study was to determine the copy number changes of chromosomes 7, 17, 3p, and Y in a non-neoplastic tubular epithelium in end-stage kidney disease (ESKD).
  • Tissues containing papillary adenomas (PA), clear (CRCC) and papillary renal cell carcinomas (PRCC), and myxoid liposarcoma (LPS) were examined using the same probes and compared with non-neoplastic tissue.
  • The basal membranes were lined by large eosinophilic epithelial cells with polymorphic nuclei and pseudostratification.
  • Fluorescence in situ hybridization on tissues containing papillary adenomas, renal cell carcinomas, and liposarcoma revealed expected results, i.e., trisomy of chromosomes 7 and 17 in all PAs and PRCC.
  • [MeSH-minor] Adenoma / genetics. Adult. Aged. Carcinoma, Renal Cell / genetics. Female. Humans. In Situ Hybridization, Fluorescence. Kidney Tubules / pathology. Liposarcoma, Myxoid / genetics. Male. Middle Aged. Trisomy / genetics. Trisomy / pathology

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  • (PMID = 18795325.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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89. Mai KT, Teo I, Belanger EC, Robertson SJ, Marginean EC, Islam S: Progesterone receptor reactivity in renal oncocytoma and chromophobe renal cell carcinoma. Histopathology; 2008 Feb;52(3):277-82
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  • MATERIALS AND METHODS: Thirty-eight RO, 25 CHRCC, 20 papillary RCC with oncocytic cytoplasm and 10 clear cell RCC with dominant eosinophilic cytoplasm were submitted for immunohistochemistry for ER, PR, CD117 and RCC.
  • In CHRCC, reactivity tended to be more prevalent in areas of tumour cells with eosinophilic cytoplasm.
  • CONCLUSIONS: PR can be used in combination with CD117 and RCC in the differential diagnosis of RO and eosinophilic variant of CHRCC with other RCC with oncocytic or eosinophilic cytoplasm.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Receptors, Progesterone / metabolism


90. Zhou CX, Gao Y: Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. Oral Oncol; 2009 Dec;45(12):e232-8
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  • We present a clinicopathologic and immunohistochemical study of 21 Chinese patients with oncocytoma of salivary gland origin, a rare benign tumour composed exclusively of large epithelial cells with eosinophilic granular cytoplasm (oncocytes).
  • Phosphotungstic acid hematoxylin staining illustrated dark-blue cytoplasmic granules, demonstrated as mitochondria by electron microscopy.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Antibodies, Antinuclear / metabolism. Antibodies, Monoclonal / metabolism. Palatal Neoplasms / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19796983.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / MIB-1 antibody; 0 / Neoplasm Proteins
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91. Garnett MR, Puget S, Grill J, Sainte-Rose C: Craniopharyngioma. Orphanet J Rare Dis; 2007;2:18
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  • The differential diagnosis includes other tumours in this region (pituitary adenoma), infectious or inflammatory processes (eosinophilic granuloma), vascular malformations (aneurysm) and congenital anomalies (Rathke's cleft cyst).
  • [MeSH-major] Craniopharyngioma / diagnosis. Craniopharyngioma / therapy. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / therapy

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  • (PMID = 17425791.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 43
  • [Other-IDs] NLM/ PMC1855047
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92. Marchesi F, Minucci S, Pelicci PG, Gobbi A, Scanziani E: Immunohistochemical detection of Ym1/Ym2 chitinase-like lectins associated with hyalinosis and polypoid adenomas of the transitional epithelium in a mouse with acute myeloid leukemia. Vet Pathol; 2006 Sep;43(5):773-6
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  • [Title] Immunohistochemical detection of Ym1/Ym2 chitinase-like lectins associated with hyalinosis and polypoid adenomas of the transitional epithelium in a mouse with acute myeloid leukemia.
  • By histopathologic examination, 2 polypoid adenomas arising from the transitional epithelium of the renal pelvis and ureter were detected.
  • The epithelial cells of the polypoid adenomas showed accumulation of hyaline eosinophilic material within the cytoplasm.
  • Large amounts of extracellular eosinophilic crystals were also associated with the transitional cell adenomas.
  • Immunohistochemical analysis revealed that the eosinophilic intracytoplasmic material and the extracellular eosinophilic crystals were composed of Ym proteins.
  • In the present PML/RARalpha knock-in female mouse, the accumulation of Ym proteins associated with the myeloid leukemia and with the polypoid adenomas of the transitional epithelium underlies 2 distinct pathogenetic mechanisms.
  • [MeSH-major] Adenoma / metabolism. Epithelium / metabolism. Glomerulosclerosis, Focal Segmental / metabolism. Lectins / metabolism. Leukemia, Myeloid, Acute / metabolism


93. Petersson F, Gatalica Z, Grossmann P, Perez Montiel MD, Alvarado Cabrero I, Bulimbasic S, Swatek A, Straka L, Tichy T, Hora M, Kuroda N, Legendre B, Michal M, Hes O: Sporadic hybrid oncocytic/chromophobe tumor of the kidney: a clinicopathologic, histomorphologic, immunohistochemical, ultrastructural, and molecular cytogenetic study of 14 cases. Virchows Arch; 2010 Apr;456(4):355-65
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  • All tumors displayed a solid alveolar architecture and were composed of cells with abundant granular eosinophilic oncocytic cytoplasm with perinuclear halos.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / genetics. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology

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  • (PMID = 20300772.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / FLCN protein, human; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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94. Wong-You-Cheong JJ, Woodward PJ, Manning MA, Davis CJ: From the archives of the AFIP: Inflammatory and nonneoplastic bladder masses: radiologic-pathologic correlation. Radiographics; 2006 Nov-Dec;26(6):1847-68
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  • Nephrogenic adenoma has no typical features, and pathologic evaluation is required for diagnosis.
  • The various types of cystitis (cystitis cystica, cystitis glandularis, and eosinophilic cystitis) require pathologic diagnosis.
  • Extrinsic inflammatory diseases such as Crohn disease and diverticulitis may be associated with fistulas to the bladder and focal bladder wall abnormality.

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  • (PMID = 17102055.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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95. Hard GC, Seely JC, Kissling GE, Betz LJ: Spontaneous occurrence of a distinctive renal tubule tumor phenotype in rat carcinogenicity studies conducted by the national toxicology program. Toxicol Pathol; 2008 Apr;36(3):388-96
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  • The hallmark features of this tumor included eosinophilic/amphophilic staining, large finely granular cells, and numerous vacuoles and/or minilumens.
  • Of 154 studies in which renal tubule tumors had been recorded in the standard single sections of kidney in the TDMS, there were collectively 1012 rats with renal adenomas, carcinomas, or adenocarcinomas, and of these, 100 displayed the distinctive AV morphology, representing 74 studies involving mostly the F344 rat, but also the Sprague-Dawley and Wistar strains.
  • The AV tumors (mainly adenomas but also some carcinomas) occurred usually as solitary lesions in the affected animals.

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  • (PMID = 18441261.001).
  • [ISSN] 1533-1601
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / N01ES95435; United States / Intramural NIH HHS / / ZIA ES045003-13; United States / NIEHS NIH HHS / ES / N01-ES-95435
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS143842; NLM/ PMC2905801
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96. Chan PC, Hill GD, Kissling GE, Nyska A: Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice. Arch Toxicol; 2008 Jan;82(1):45-53
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  • The incidences of hepatocellular eosinophilic and mixed cell foci were significantly increased in 2,500 ppm males and 5,000 ppm females.
  • The incidences of alveolar/bronchiolar adenoma in all exposed groups of females, alveolar/bronchiolar carcinoma in 1,250 ppm males, and alveolar/bronchiolar adenoma or carcinoma (combined) in 1,250 ppm males and 625- and 1,250 ppm females were significantly greater than those in the control groups.
  • 4MI is carcinogenic inducing alveolar/bronchiolar adenoma and carcinoma in male and female mice.

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  • (PMID = 17619857.001).
  • [ISSN] 0340-5761
  • [Journal-full-title] Archives of toxicology
  • [ISO-abbreviation] Arch. Toxicol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Imidazoles; Q64GF9FV4I / 4-methylimidazole
  • [Other-IDs] NLM/ NIHMS44466; NLM/ PMC2366200
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97. Yang XJ, Zhou M, Hes O, Shen S, Li R, Lopez J, Shah RB, Yang Y, Chuang ST, Lin F, Tretiakova MM, Kort EJ, Teh BT: Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterization. Am J Surg Pathol; 2008 Feb;32(2):177-87
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The epithelial lining cells of the tubules and cysts in this tumor were characterized by abundant eosinophilic cytoplasm with prominent nucleoli often showing a hobnail appearance.
  • Five of the 13 cases coexisted with papillary renal cell carcinoma (RCC) (n=3) or papillary adenoma (n=2).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chromosomes, Human, Pair 17. Disease-Free Survival. Female. Fluorescent Antibody Technique, Indirect. Gene Expression Regulation, Neoplastic. Humans. Lymph Nodes / pathology. Male. Middle Aged. Neoplasms, Multiple Primary. Oligonucleotide Array Sequence Analysis

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  • (PMID = 18223319.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Demirović A, Džombeta T, Tomas D, Spajić B, Pavić I, Hudolin T, Milošević M, Cupić H, Krušlin B: Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma. Pathol Res Pract; 2010 Oct 15;206(10):695-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The distinction between renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC), especially the eosinophilic variant, can often be difficult.
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / immunology. Adenoma, Oxyphilic / pathology. Aged. Aged, 80 and over. Croatia. Diagnosis, Differential. Female. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / immunology. Kidney Neoplasms / pathology. Male. Middle Aged. Predictive Value of Tests


99. Montone KT, Baloch ZW, LiVolsi VA: The thyroid Hürthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review. Arch Pathol Lab Med; 2008 Aug;132(8):1241-50
MedlinePlus Health Information. consumer health - Thyroid Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONTEXT: Hürthle cells are eosinophilic, follicular-derived cells that are associated with a variety of nonneoplastic and neoplastic thyroid lesions.
  • DATA SOURCES: A variety of thyroid nonneoplastic (autoimmune thyroiditis, multinodular goiter) and neoplastic conditions (Hürthle cell adenoma, Hürthle cell carcinoma) are associated with Hürthle cell cytology.
  • [MeSH-major] Oxyphil Cells / pathology. Thyroid Diseases / pathology. Thyroid Gland / pathology

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  • (PMID = 18684023.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 107
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100. Volante M, La Rosa S, Castellano I, Finzi G, Capella C, Bussolati G: Clinico-pathological features of a series of 11 oncocytic endocrine tumours of the pancreas. Virchows Arch; 2006 May;448(5):545-51
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  • The morphological features and immunophenotype of such tumours did not differ from conventional endocrine pancreatic tumours, except for the presence of abundant eosinophilic and granular cytoplasm.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 16491376.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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