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1. Little JW: Thyroid disorders. Part III: neoplastic thyroid disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Sep;102(3):275-80
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  • Thyroid tumors are the most common endocrine neoplasms.
  • An important neoplastic syndrome, multiple endocrine neoplasia type 2 (MEN2), involves medullary carcinoma of the thyroid gland.
  • [MeSH-minor] Adenoma / blood. Adenoma / diagnosis. Carcinoma / blood. Carcinoma / diagnosis. Carcinoma, Medullary / blood. Carcinoma, Medullary / diagnosis. Diagnosis, Differential. Humans

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  • (PMID = 16920533.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. DeLellis RA: Pathology and genetics of thyroid carcinoma. J Surg Oncol; 2006 Dec 15;94(8):662-9
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  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Carcinoma / pathology. Genes, ras. Humans. Molecular Biology. Multiple Endocrine Neoplasia / genetics. Mutation. PTEN Phosphohydrolase / genetics. Point Mutation. Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins c-ret / genetics. Receptor, trkA / genetics

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  • (PMID = 17131411.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / Receptor, trkA; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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3. Imelda F, Bandar IN, Setiyohadi B, Suwondo P, Nasar IM, Darwito: Postural shortening due to primary hyperparathyroidism caused by parathyroid adenoma. Acta Med Indones; 2006 Apr-Jun;38(2):89-91
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  • [Title] Postural shortening due to primary hyperparathyroidism caused by parathyroid adenoma.
  • Secondary osteoporosis is the result of an underlying disease such as an endocrine abnormality, and an example of such is primary hyperparathyroidism.
  • The most common cause of primary hyperparathyroidism is parathyroid gland adenoma.
  • The patient was diagnosed with primary hyperparathyroidism caused by parathyroid gland adenoma.
  • [MeSH-major] Adenoma / diagnosis. Body Height / physiology. Hyperparathyroidism, Primary / physiopathology. Parathyroid Neoplasms / diagnosis

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  • (PMID = 16799210.001).
  • [ISSN] 0125-9326
  • [Journal-full-title] Acta medica Indonesiana
  • [ISO-abbreviation] Acta Med Indones
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Indonesia
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4. Ogawa Y, Watanabe M, Tominaga T: Somatostatin-producing atypical null cell adenoma manifesting as severe hypopituitarism and rapid deterioration--case report. Endocr Pathol; 2010 Jun;21(2):130-4
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  • [Title] Somatostatin-producing atypical null cell adenoma manifesting as severe hypopituitarism and rapid deterioration--case report.
  • Atypical adenoma has an aggressive biological character, invades the surrounding structures, and grows rapidly.
  • Null cell adenoma generally grows slowly, but hormone secretion is little understood.
  • Atypical null cell adenoma is rare, and hormone production is unknown.
  • Histological examination showed atypical null cell adenoma with significant nuclear atypism and extensive necrosis.
  • Atypical null cell adenoma has an aggressive biological character, and immediate adjuvant treatment is essential.
  • [MeSH-major] Adenoma / pathology. Pituitary Neoplasms / pathology. Somatostatin / biosynthesis

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  • [ErratumIn] Endocr Pathol. 2010 Dec;21(4):277
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  • (PMID = 20174891.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 51110-01-1 / Somatostatin
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5. Salehi F, Cohen S, Syro LV, Uribe H, Horvath E, Kovacs K, Asa SL: Plurihormonality in pituitary adenomas associated with acromegaly. Endocr Pathol; 2006;17(3):291-6
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  • [MeSH-major] Acromegaly / etiology. Adenoma / complications. Immunohistochemistry. Pituitary Hormones, Anterior / secretion. Pituitary Neoplasms / complications

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  • (PMID = 17308366.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Pituitary Hormones, Anterior
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6. Koc K, Anik I, Ozdamar D, Cabuk B, Keskin G, Ceylan S: The learning curve in endoscopic pituitary surgery and our experience. Neurosurg Rev; 2006 Oct;29(4):298-305; discussion 305
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma / complications. Adenoma / surgery. Adolescent. Adult. Aged. Child. Endocrine System / physiology. Female. Fibrin Tissue Adhesive. Humans. Learning. Male. Middle Aged. Pituitary Neoplasms / complications. Pituitary Neoplasms / surgery. Postoperative Care. Radiography. Sella Turcica / surgery. Stereotaxic Techniques. Tissue Adhesives

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  • [ErratumIn] Neurosurg Rev. 2007 Jan;30(1):96. Kenan, Koc [corrected to Koc, Kenan]; Ihsan, Anik [corrected to Anik, Ihsan]; Dilek, Ozdamar [corrected to Ozdamar, Dilek]; Burak, Cabuk [corrected to Cabuk, Burak]; Gurkan, Keskin [corrected to Keskin, Gurkan]; Savas, Ceylan [corrected to Ceylan, Savas]
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  • (PMID = 16937143.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Tissue Adhesives
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7. Liu JK, Couldwell WT: Pituitary apoplexy in the magnetic resonance imaging era: clinical significance of sphenoid sinus mucosal thickening. J Neurosurg; 2006 Jun;104(6):892-8
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  • A clinical grading scale for apoplexy was devised as follows: Grade I, presence of acute headache and/or endocrine abnormality (12 patients); Grade II, presence of the foregoing symptoms as well as cranial nerve deficit (visual and/or oculomotor; 15 patients); and Grade III, presence of all of these symptoms and a decreased level of consciousness (one patient).
  • [MeSH-minor] Adenoma / complications. Adenoma / pathology. Adenoma / therapy. Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Mucous Membrane / pathology. Pituitary Neoplasms / complications. Pituitary Neoplasms / pathology. Pituitary Neoplasms / therapy. Retrospective Studies. Severity of Illness Index. Treatment Outcome

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  • (PMID = 16776332.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Semple PL, De Villiers JC, Bowen RM, Lopes MB, Laws ER Jr: Pituitary apoplexy: do histological features influence the clinical presentation and outcome? J Neurosurg; 2006 Jun;104(6):931-7
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  • The endocrine replacement requirements were similar in both groups.
  • [MeSH-minor] Adenoma / blood supply. Adenoma / pathology. Adenoma / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pituitary Neoplasms / blood supply. Pituitary Neoplasms / pathology. Pituitary Neoplasms / surgery. Retrospective Studies. Treatment Outcome

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  • (PMID = 16776337.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Kollars J, Zarroug AE, van Heerden J, Lteif A, Stavlo P, Suarez L, Moir C, Ishitani M, Rodeberg D: Primary hyperparathyroidism in pediatric patients. Pediatrics; 2005 Apr;115(4):974-80
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  • Serum calcium was elevated in all patients except for 2 with multiple endocrine neoplasma (MEN)-IIA and 1 with familial non-MEN HPT, but both had elevated PTH levels.
  • Thirty-four patients (65%) had a single adenoma; hyperplasia was identified in 16 patients (27%), and of these cases, 57% occurred in patients diagnosed with MEN-I.
  • [MeSH-minor] Adenoma / complications. Adolescent. Bone Diseases, Metabolic / etiology. Child. Child, Preschool. Female. Humans. Hypercalcemia / etiology. Hypocalcemia / etiology. Kidney Calculi / etiology. Male. Multiple Endocrine Neoplasia / complications. Nephrocalcinosis / etiology. Parathyroid Hormone / blood. Parathyroid Neoplasms / complications. Parathyroidectomy. Postoperative Complications. Retrospective Studies. Sex Distribution

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  • [CommentIn] Pediatrics. 2005 Apr;115(4):1073 [15805388.001]
  • (PMID = 15805373.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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10. Thomas D, Alexandraki K, Nikolaou A, Antoniou S, Kanakis G, Zilos A, Sougioultzis S, Kaltsas G: Primary hyperparathyroidism in patients with gastric carcinoid tumors type 1: an unusual coexistence. Neuroendocrinology; 2010;92(4):252-8
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  • Four control groups were also studied: two age- and sex-matched groups of individuals with (n = 49) and without (n = 34) thyroid autoimmunity and normal endoscopy of the stomach, a third group with nongastric neuroendocrine tumors (n = 68), and a fourth group with atrophic gastritis and hypergastrinemia, without gastric endocrine tumors (n = 30).
  • Three of the 4 patients with PHP were operated and proved to have a parathyroid adenoma.
  • [MeSH-minor] Adenoma / complications. Adenoma / epidemiology. Adult. Aged. Aged, 80 and over. Case-Control Studies. Female. Humans. Incidence. Male. Middle Aged. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / epidemiology. Retrospective Studies. Young Adult


11. Davies K, Conlon KC: Neuroendocrine tumors of the pancreas. Curr Gastroenterol Rep; 2009 Apr;11(2):119-27
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  • Pancreatic endocrine tumors are rare neoplasms accounting for less than 5% of pancreatic malignancies.
  • Further development of novel diagnostic and treatment modalities offers potential to greatly improve quality of life and prolong disease-free survival for patients with pancreatic endocrine tumors.
  • [MeSH-major] Adenoma, Islet Cell. Carcinoma, Islet Cell. Pancreatic Neoplasms

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  • [Journal-full-title] Current gastroenterology reports
  • [ISO-abbreviation] Curr Gastroenterol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gastrins; 0 / Insulin; 51110-01-1 / Somatostatin; 9007-92-5 / Glucagon
  • [Number-of-references] 44
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12. Molitch ME: Pituitary tumours: pituitary incidentalomas. Best Pract Res Clin Endocrinol Metab; 2009 Oct;23(5):667-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / diagnosis. Incidental Findings. Pituitary Neoplasms / diagnosis
  • [MeSH-minor] Algorithms. Autopsy. Continuity of Patient Care. Diagnostic Techniques, Endocrine. Follow-Up Studies. Humans. Pituitary Diseases / diagnosis. Pituitary Diseases / epidemiology. Prevalence

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  • (PMID = 19945030.001).
  • [ISSN] 1878-1594
  • [Journal-full-title] Best practice & research. Clinical endocrinology & metabolism
  • [ISO-abbreviation] Best Pract. Res. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 84
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13. Zeng Y, Yokohira M, Takeuchi H, Saoo K, Yamakawa K, Matsuda Y, Hosokawa K, Li JQ, Ikeda M, Imaida K: Lack of significant modifying effect of arctiin on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Lett; 2005 May 26;222(2):145-51
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  • Arctiin, a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis.
  • [MeSH-major] Adenoma / physiopathology. Furans / pharmacology. Glucosides / pharmacology. Prostatic Neoplasms / physiopathology

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  • (PMID = 15863263.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Androgen-Binding Protein; 0 / Antigens, Polyomavirus Transforming; 0 / Drugs, Chinese Herbal; 0 / Furans; 0 / Glucosides; 0 / probasin; TM5RQ949K7 / arctiin
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14. Ali A, Serra S, Asa SL, Chetty R: The predictive value of CK19 and CD99 in pancreatic endocrine tumors. Am J Surg Pathol; 2006 Dec;30(12):1588-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The predictive value of CK19 and CD99 in pancreatic endocrine tumors.
  • Prediction of behavior in pancreatic endocrine tumors (PETs) is reliant on clinicopathologic features.
  • [MeSH-major] Adenoma, Islet Cell / metabolism. Antigens, CD / metabolism. Carcinoma, Islet Cell / metabolism. Cell Adhesion Molecules / metabolism. Keratin-19 / metabolism. Pancreatic Neoplasms / metabolism

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  • (PMID = 17122516.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Keratin-19
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15. Norman JG, Politz DE: Safety of immediate discharge after parathyroidectomy: a prospective study of 3,000 consecutive patients. Endocr Pract; 2007 Mar-Apr;13(2):105-13
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  • The amount of oral calcium supplementation prescribed postoperatively varied according to a protocol that considered the degree of serum calcium elevation preoperatively as well as the intraoperative findings (hyperplasia versus adenoma).

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  • (PMID = 17490922.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] SY7Q814VUP / Calcium
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16. Liau SS, Hill-Cawthorne G, Wishart GC, Wells FC: Use of an improvised sternal retractor for mediastinal parathyroidectomy through a cervical incision. Ann R Coll Surg Engl; 2008 Jul;90(5):430-1
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  • [MeSH-major] Adenoma / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy / instrumentation. Surgical Instruments

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  • (PMID = 18642425.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2645761
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17. Kim DH, Nagano Y, Choi IS, White JA, Yao JC, Rashid A: Allelic alterations in well-differentiated neuroendocrine tumors (carcinoid tumors) identified by genome-wide single nucleotide polymorphism analysis and comparison with pancreatic endocrine tumors. Genes Chromosomes Cancer; 2008 Jan;47(1):84-92
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  • [Title] Allelic alterations in well-differentiated neuroendocrine tumors (carcinoid tumors) identified by genome-wide single nucleotide polymorphism analysis and comparison with pancreatic endocrine tumors.
  • We used genome-wide high-density single nucleotide polymorphism (SNP) array analysis to detect copy number alterations in 29 WDNTs, including seven lung, seven nonileal gastrointestinal, and 15 ileal tumors, and compared with allelic imbalances in 15 pancreatic endocrine tumors (PETs).
  • [MeSH-major] Adenoma, Islet Cell / genetics. Allelic Imbalance. Carcinoid Tumor / genetics. Cell Differentiation / genetics. Genome, Human. Polymorphism, Single Nucleotide

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  • (PMID = 17943967.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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18. Wolf A, Willenberg HS, Cupisti K, Schott M, Geddert H, Raffel A, Bornstein SR, Scherbaum WA, Knoefel WT: Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management. Horm Metab Res; 2005 Jun;37(6):391-5
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  • [Title] Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management.
  • To contribute to the studies of systemic interactions between these tissues, we studied a 52-year-old female patient with a pheochromocytoma and a contralateral cortisol-producing adenoma.
  • Due to excess catecholamine secretion, bilateral pheochromocytomas based on multiple endocrine neoplasia syndrome were suspected.
  • Laboratory work-up, selective adrenal venous sampling and magnetic resonance imaging studies established the diagnosis of a pheochromocytoma in the right-hand adrenal gland and a cortisol-producing adenoma on the left.
  • Although presence of bilateral adrenal adenomas or bilateral adrenal pheochromocytomas in certain inherited disorders are possible, this rare case of an adrenal pheochromocytoma combined with a contralateral cortisol-producing adrenal adenoma may further underline the wide range of complex interactions between the two endocrine systems.
  • [MeSH-major] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Pheochromocytoma / radiography

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  • (PMID = 16001333.001).
  • [ISSN] 0018-5043
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] WI4X0X7BPJ / Hydrocortisone
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19. Minniti G, Gilbert DC, Brada M: Modern techniques for pituitary radiotherapy. Rev Endocr Metab Disord; 2009 Jun;10(2):135-44
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  • SCRT is a suitable treatment technique for all sizes of pituitary adenoma and efficacy is comparable to conventional RT; the lack of long term follow up means that currently there is no information on potential reduction in the incidence of late radiation induced toxicity.

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  • (PMID = 18787957.001).
  • [ISSN] 1573-2606
  • [Journal-full-title] Reviews in endocrine & metabolic disorders
  • [ISO-abbreviation] Rev Endocr Metab Disord
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Number-of-references] 101
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21. Serra S, Asa SL, Chetty R: Intracytoplasmic inclusions (including the so-called "rhabdoid" phenotype) in pancreatic endocrine tumors. Endocr Pathol; 2006;17(1):75-81
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  • [Title] Intracytoplasmic inclusions (including the so-called "rhabdoid" phenotype) in pancreatic endocrine tumors.
  • The cytoplasm of pancreatic endocrine tumors (PET) can show a diverse range of appearances from clear, to oncocytic, to intracellular mucin accumulation, and the presence of intracytoplasmic inclusions.
  • [MeSH-major] Adenoma, Islet Cell / pathology. Carcinoma, Islet Cell / pathology. Inclusion Bodies / pathology. Multiple Endocrine Neoplasia Type 1 / pathology. Pancreatic Neoplasms / pathology. Rhabdoid Tumor / pathology

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  • (PMID = 16760583.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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22. Ippolito G, Palazzo FF, Sebag F, De Micco C, Henry JF: Intraoperative diagnosis and treatment of parathyroid cancer and atypical parathyroid adenoma. Br J Surg; 2007 May;94(5):566-70
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  • [Title] Intraoperative diagnosis and treatment of parathyroid cancer and atypical parathyroid adenoma.
  • BACKGROUND: Distinction of parathyroid cancer from atypical parathyroid adenoma (APA) at operation is difficult.
  • [MeSH-major] Adenoma / diagnosis. Parathyroid Neoplasms / diagnosis. Parathyroidectomy / methods

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  • [CommentIn] Br J Surg. 2007 Aug;94(8):1043; author reply 1043-4 [17636522.001]
  • [CommentIn] Br J Surg. 2007 Aug;94(8):1042-3; author reply 1043-4 [17636521.001]
  • (PMID = 17380564.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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23. Carsote M, Chirita C, Dumitrascu A, Hortopan D, Fica S, Poiana C: Pituitary incidentalomas--how often is too often? J Med Life; 2009 Jan-Mar;2(1):92-7
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  • We have also analysed their behavior with respect to their endocrine phenotype and the minimum period of time needed for the repetition of the imagistic procedure.
  • [MeSH-major] Adenoma / diagnosis. Pituitary Neoplasms / diagnosis

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  • (PMID = 20108497.001).
  • [ISSN] 1844-122X
  • [Journal-full-title] Journal of medicine and life
  • [ISO-abbreviation] J Med Life
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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24. Trésallet C, Salepçioglu H, Godiris-Petit G, Hoang C, Girerd X, Menegaux F: Clinical outcome after laparoscopic adrenalectomy for primary hyperaldosteronism: the role of pathology. Surgery; 2010 Jul;148(1):129-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pre-operative assessment rarely differentiates adrenal adenoma from hyperplasia.
  • Thirty-six patients (63%) had an adrenal adenoma and 21 (37%) a hyperplasia.
  • Pre-operative diagnosis of adenoma or hyperplasia is not mandatory but it is important to warn patients that hypertension can persist after adrenalectomy, especially in case of adrenal hyperplasia, although this hypertension is easier to control.

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • [CommentIn] Surgery. 2011 Jun;149(6):852 [21208633.001]
  • (PMID = 20083287.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone; EC 3.4.23.15 / Renin
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25. Dossett LA, Rudzinski ER, Blevins LS, Chambers EP Jr: Malignant pheochromocytoma of the organ of Zuckerkandl requiring aortic and vena caval reconstruction. Endocr Pract; 2007 Sep;13(5):493-7
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  • Imaging characteristics of the left adrenal mass were consistent with a benign adenoma, but CT also demonstrated a hypervascular para-aortic mass.

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  • (PMID = 17872352.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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26. Kidambi S, Raff H, Findling JW: Limitations of nocturnal salivary cortisol and urine free cortisol in the diagnosis of mild Cushing's syndrome. Eur J Endocrinol; 2007 Dec;157(6):725-31
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  • All patients had appropriate surgery, and histopathology of all except one was suggestive of either a cortisol-producing adrenal adenoma or an ACTH-secreting pituitary adenoma.

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  • (PMID = 18057379.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 7S5I7G3JQL / Dexamethasone; WI4X0X7BPJ / Hydrocortisone
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27. Zhan X, Desiderio DM: Signaling pathway networks mined from human pituitary adenoma proteomics data. BMC Med Genomics; 2010 Apr 28;3:13
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  • [Title] Signaling pathway networks mined from human pituitary adenoma proteomics data.
  • BACKGROUND: We obtained a series of pituitary adenoma proteomic expression data, including protein-mapping data (111 proteins), comparative proteomic data (56 differentially expressed proteins), and nitroproteomic data (17 nitroproteins).
  • There is a pressing need to clarify the significant signaling pathway networks that derive from those proteins in order to clarify and to better understand the molecular basis of pituitary adenoma pathogenesis and to discover biomarkers.
  • Here, we describe the significant signaling pathway networks that were mined from human pituitary adenoma proteomic data with the Ingenuity pathway analysis system.
  • METHODS: The Ingenuity pathway analysis system was used to analyze signal pathway networks and canonical pathways from protein-mapping data, comparative proteomic data, adenoma nitroproteomic data, and control nitroproteomic data.
  • Statistical significant results were rationalized within the pituitary adenoma biological system with literature-based bioinformatics analyses.
  • For the comparative proteomic data, top pathway networks were related to cancer, endocrine system development and function, and lipid metabolism; the top canonical toxicity pathways included mitochondrial dysfunction, oxidative phosphorylation, oxidative-stress response, and ERK/MAPK signaling.
  • The nitroproteomic data from a pituitary adenoma were related to cancer, cell death, lipid metabolism, and reproductive system disease, and the top canonical toxicity pathways mainly related to p38 MAPK signaling and cell-cycle G2/M transition regulation.
  • CONCLUSIONS: This pathway network analysis demonstrated that mitochondrial dysfunction, oxidative stress, cell-cycle dysregulation, and the MAPK-signaling abnormality are significantly associated with a pituitary adenoma.
  • These pathway-network data provide new insights into the molecular mechanisms of human pituitary adenoma pathogenesis, and new clues for an in-depth investigation of pituitary adenoma and biomarker discovery.

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  • (PMID = 20426862.001).
  • [ISSN] 1755-8794
  • [Journal-full-title] BMC medical genomics
  • [ISO-abbreviation] BMC Med Genomics
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / RR016679
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cell Cycle Proteins; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
  • [Other-IDs] NLM/ PMC2884164
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28. Marsh WL, Colonna J, Yearsley M, Bloomston M, Frankel WL: Calponin is expressed in serous cystadenomas of the pancreas but not in adenocarcinomas or endocrine tumors. Appl Immunohistochem Mol Morphol; 2009 May;17(3):216-9
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  • [Title] Calponin is expressed in serous cystadenomas of the pancreas but not in adenocarcinomas or endocrine tumors.
  • The diagnosis of serous microcystic adenoma (SMA) is usually straightforward.
  • Additionally, microarrays previously constructed from 56 pancreatic adenocarcinomas (PACs) and 64 pancreatic endocrine tumors (PENs) were studied.

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  • (PMID = 19391217.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Microfilament Proteins; 0 / calponin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 4.2.1.11 / Phosphopyruvate Hydratase
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29. Shigematsu K, Yamaguchi N, Nakagaki T, Sakai H: A case of unilateral adrenal hyperplasia being difficult to distinguish from aldosterone-producing adenoma. Exp Clin Endocrinol Diabetes; 2009 Mar;117(3):124-8
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  • [Title] A case of unilateral adrenal hyperplasia being difficult to distinguish from aldosterone-producing adenoma.
  • Unilateral adrenal hyperplasia (UAH) is very rare, and shows similar endocrine features to aldosterone-producing adenoma (APA).
  • However, in situ hybridization and real-time PCR indicated that the hyperplastic zona glomerulosa cells rather than the adenoma cells demonstrated intense mRNA expression of steroidogenic enzymes necessary for production of aldosterone.
  • [MeSH-major] Adenoma / blood. Adenoma / diagnosis. Adrenal Gland Neoplasms / blood. Adrenal Gland Neoplasms / diagnosis. Aldosterone / biosynthesis. Aldosterone / blood. Hyperplasia / diagnosis

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  • (PMID = 18561092.001).
  • [ISSN] 1439-3646
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / RNA, Messenger; 4964P6T9RB / Aldosterone; EC 1.14.15.4 / Cytochrome P-450 CYP11B2
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30. Schreinemakers JM, Kiela GJ, Valk GD, Vriens MR, Rinkes IH: Retroperitoneal endoscopic adrenalectomy is safe and effective. Br J Surg; 2010 Nov;97(11):1667-72
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  • Thirty-nine patients with unilateral adrenal disease had a phaeochromocytoma, of whom 16 had multiple endocrine neoplasia syndrome type 2, 21 patients had Cushing's disease and 20 had Conn's disease.
  • [MeSH-minor] Adolescent. Adrenocortical Adenoma / surgery. Adult. Aged. Child. Epidemiologic Methods. Humans. Middle Aged. Pheochromocytoma / surgery. Pituitary ACTH Hypersecretion / surgery. Retroperitoneal Space. Treatment Outcome. Young Adult

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  • [Copyright] Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • [CommentIn] Br J Surg. 2010 Nov;97(11):1672-3 [20890917.001]
  • (PMID = 20665481.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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31. Fernandez A, Karavitaki N, Wass JA: Prevalence of pituitary adenomas: a community-based, cross-sectional study in Banbury (Oxfordshire, UK). Clin Endocrinol (Oxf); 2010 Mar;72(3):377-82
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  • All cases of PAs were found following an exhaustive computer database search of agreed terms by the staff of each Practice and data on age, gender, presenting manifestations and their duration, imaging features at diagnosis, history of multiple endocrine neoplasia type 1 and family history of PA were collected.
  • RESULTS: A total of 63 patients with PA were identified amongst the study population of 81,149, with a prevalence of 77.6 PA cases/100,000 inhabitants (prolactinomas; PRLoma: 44.4, nonfunctioning PAs: 22.2, acromegaly; ACRO: 8.6, corticotroph adenoma: 1.2 and unknown functional status; UFS: 1.2/100,000 inhabitants).
  • The distribution of each PA subtype was for PRLoma 57%, nonfunctioning PAs 28%, ACRO 11%, corticotroph adenoma 2% and UFS 2%.
  • The median age at diagnosis and the duration of symptoms until diagnosis (in years) were for PRLoma 32.0 and 1.5, nonfunctioning PAs 51.5 and 0.8, ACRO 47 and 4.5 and corticotroph adenoma 57 and 7, respectively.
  • [MeSH-major] Adenoma / epidemiology. Pituitary Neoplasms / epidemiology

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  • [CommentIn] Clin Endocrinol (Oxf). 2010 Mar;72(3):290-1 [19832856.001]
  • (PMID = 19650784.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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32. Katznelson L: Diagnosis and treatment of acromegaly. Growth Horm IGF Res; 2005 Jul;15 Suppl A:S31-5
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  • Acromegaly is an insidious disease that occurs, in the majority of cases, as a result of a pituitary adenoma that hypersecretes growth hormone (GH).
  • This brief review will describe current recommendations for management of this uncommon, but debilitating, endocrine disorder.

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  • (PMID = 16023876.001).
  • [ISSN] 1096-6374
  • [Journal-full-title] Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • [ISO-abbreviation] Growth Horm. IGF Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Scotland
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I
  • [Number-of-references] 34
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33. Garnett MR, Puget S, Grill J, Sainte-Rose C: Craniopharyngioma. Orphanet J Rare Dis; 2007;2:18
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  • The onset of symptoms is normally insidious with most patients at diagnosis having neurological (headaches, visual disturbances) and endocrine (growth retardation, delayed puberty) dysfunctions.
  • The differential diagnosis includes other tumours in this region (pituitary adenoma), infectious or inflammatory processes (eosinophilic granuloma), vascular malformations (aneurysm) and congenital anomalies (Rathke's cleft cyst).
  • Endocrine disturbances are normally permanent and need careful replacement.

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  • (PMID = 17425791.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 43
  • [Other-IDs] NLM/ PMC1855047
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34. Soon PS, Yeh MW, Sywak MS, Roach P, Delbridge LW, Sidhu SB: Minimally invasive parathyroidectomy using the lateral focused miniincision approach: Is there a learning curve for surgeons experienced in the open procedure? J Am Coll Surg; 2007 Jan;204(1):91-5
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  • BACKGROUND: Minimally invasive parathyroidectomy (MIP) has gained acceptance as the standard of care for management of primary hyperparathyroidism in which a single adenoma can be localized.
  • STUDY DESIGN: This is a retrospective case series comprising all parathyroid operations undertaken by three surgeons in the University of Sydney Endocrine Surgical Unit from 2003 to 2005.

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  • (PMID = 17189117.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Ogawa Y, Tominaga T: A case of atypical thyrotroph cell adenoma, which re-grew within 3 months after surgery and required multimodal treatment. J Neurooncol; 2008 Mar;87(1):91-5
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  • [Title] A case of atypical thyrotroph cell adenoma, which re-grew within 3 months after surgery and required multimodal treatment.
  • OBJECTIVE AND IMPORTANCE: Thyrotroph cell adenoma accounts for only 1% of all pituitary adenomas.
  • Atypical adenoma has an aggressive biological character, invades the surrounding structures, and grows rapidly.
  • Atypical thyrotroph cell adenoma is extremely rare.
  • Histological examination showed atypical thyrotroph cell adenoma.
  • CONCLUSION: Atypical thyrotroph cell adenoma has an aggressive biological character and grows rapidly.
  • [MeSH-major] Adenoma / therapy. Neoplasm Recurrence, Local / therapy. Pituitary Neoplasms / therapy. Thyrotrophs / pathology

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  • (PMID = 17987261.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; RWM8CCW8GP / Octreotide
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36. Beckers A, Apetrii P, Daly A, Tichomirova M, Vanbellingen JF, Georges M, Bours V: [Clinical and genetic characterization of FIPA (familial isolated pituitary adenomas)]. Rev Med Liege; 2009;64 Spec No:15-9
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  • [MeSH-major] Adenoma / genetics. Pituitary Neoplasms / genetics
  • [MeSH-minor] Acromegaly / etiology. Carney Complex / genetics. Fibrous Dysplasia, Polyostotic / genetics. Humans. Multiple Endocrine Neoplasia / genetics

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  • (PMID = 20085010.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Belgium
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37. Yawar A, Zuberi LM, Haque N: Cushing's disease and pregnancy: case report and literature review. Endocr Pract; 2007 May-Jun;13(3):296-9
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  • [MeSH-major] ACTH-Secreting Pituitary Adenoma / complications. Adenoma. Pituitary ACTH Hypersecretion / etiology. Pituitary Neoplasms / complications. Pregnancy Complications

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  • (PMID = 17599863.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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38. Dugonjić S, Ajdinović B, Cerović S, Janković Z: Validity of dual tracer 99mTc-tetrofosmin and 99mTc-pertechnetate subtraction parathyroid scintigraphy in patients with primary and secondary hyperparathyroidism. Vojnosanit Pregl; 2009 Dec;66(12):949-53
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  • BACKGROUND/AIM: Primary hyperparathyroidism (pHPT) is an endocrine disease with the third highest incidence of all endocrine disorders after diabetes mellitus and hyperthyroidism. pHPT is typically caused by a solitary parathyroid adenoma, less frequently by multiple parathyroid gland disease (MGD) and rarely by parathyroid carcinoma.

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  • (PMID = 20095513.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Serbia
  • [Chemical-registry-number] 0 / Organophosphorus Compounds; 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane; A0730CX801 / Sodium Pertechnetate Tc 99m
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39. Aiba M, Fujibayashi M: Histopathological diagnosis and prognostic factors in adrenocortical carcinoma. Endocr Pathol; 2005;16(1):13-22
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  • [MeSH-minor] Adenoma, Oxyphilic. Adult. Aged. Aged, 80 and over. Aldosterone / metabolism. Biomarkers, Tumor / metabolism. Cell Nucleus / pathology. Female. Humans. Immunohistochemistry. Infant. Insulin-Like Growth Factor II / metabolism. Male. Neoplasm Staging. Prognosis

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  • (PMID = 16000842.001).
  • [ISSN] 1046-3976
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  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
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40. Georgitsi M, Raitila A, Karhu A, Tuppurainen K, Mäkinen MJ, Vierimaa O, Paschke R, Saeger W, van der Luijt RB, Sane T, Robledo M, De Menis E, Weil RJ, Wasik A, Zielinski G, Lucewicz O, Lubinski J, Launonen V, Vahteristo P, Aaltonen LA: Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations. Proc Natl Acad Sci U S A; 2007 Mar 6;104(10):4101-5
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  • [Title] Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations.
  • Germ-line mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene cause pituitary adenoma predisposition (PAP), a recent discovery based on genetic studies in Northern Finland.
  • To evaluate the role of AIP in pituitary adenoma susceptibility in other populations and to gain insight into patient selection for molecular screening of the condition, we investigated the possible contribution of AIP mutations in pituitary tumorigenesis in patients from Europe and the United States.
  • A total of 460 patients were investigated by AIP sequencing: young acromegaly patients, unselected acromegaly patients, unselected pituitary adenoma patients, and endocrine neoplasia-predisposition patients who were negative for MEN1 mutations.
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Intracellular Signaling Peptides and Proteins. Male. Middle Aged. Molecular Sequence Data. Multiple Endocrine Neoplasia / genetics

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  • (PMID = 17360484.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ EF203234/ EF203235/ EF203236/ EF203237/ EF203238/ EF203239/ EF203240
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Proteins; 0 / aryl hydrocarbon receptor-interacting protein
  • [Other-IDs] NLM/ PMC1820715
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41. Pulitzer M, Xu R, Suriawinata AA, Waye JD, Harpaz N: Microcarcinoids in large intestinal adenomas. Am J Surg Pathol; 2006 Dec;30(12):1531-6
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  • Composite adenoma-carcinoid tumors are rare colorectal lesions consisting of intermingled adenomatous and carcinoid components.
  • Unlike other mixed endocrine-glandular colorectal neoplasms, which are generally malignant, their glandular component is histologically benign and their natural history is favorable.
  • We present 4 cases of colonic adenomas containing microcarcinoids, a hitherto undescribed lesion that is either a precursor of composite adenoma-carcinoids or a related but independent entity.
  • Endocrine differentiation of the microcarcinoids was confirmed by the expression of 3 or more of the following: Grimelius argyrophil, chromogranin, synaptophysin, neuron-specific enolase and somatostatin.
  • The glandular component of the polyps was unremarkable in 3 cases, but 1 polyp, in addition to a microcarcinoid, showed a diffuse pattern of mixed adenomatous-endocrine differentiation.
  • Two patients with incomplete polypectomies underwent hemicolectomy revealing no residual endocrine neoplasia.
  • [MeSH-major] Adenoma / pathology. Carcinoid Tumor / pathology. Intestinal Neoplasms / pathology. Intestine, Large / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17122508.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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42. Riss P, Asari R, Scheuba C, Bieglmayer C, Niederle B: PTH secretion of "manipulated" parathyroid adenomas. Langenbecks Arch Surg; 2009 Sep;394(5):891-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / surgery. Parathyroid Hormone / secretion. Parathyroid Neoplasms / surgery. Parathyroidectomy

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  • (PMID = 19396458.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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43. Morana G, Maghnie M, Rossi A: Pituitary tumors: advances in neuroimaging. Endocr Dev; 2010;17:160-74
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  • Magnetic resonance imaging (MRI) represents the examination method of choice for evaluating hypothalamic-pituitary-related endocrine diseases due to its ability to provide strongly contrasted high-resolution, multiplanar and spatial images.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Central Nervous System Cysts / diagnosis. Central Nervous System Cysts / pathology. Child. Craniopharyngioma / diagnosis. Craniopharyngioma / pathology. Diagnosis, Differential. Germinoma / diagnosis. Germinoma / pathology. Humans. Hyperplasia / pathology. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 19955765.001).
  • [ISSN] 1662-2979
  • [Journal-full-title] Endocrine development
  • [ISO-abbreviation] Endocr Dev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
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44. Stewart ZA, Blackford A, Somervell H, Friedman K, Garrett-Mayer E, Dackiw AP, Zeiger MA: 25-hydroxyvitamin D deficiency is a risk factor for symptoms of postoperative hypocalcemia and secondary hyperparathyroidism after minimally invasive parathyroidectomy. Surgery; 2005 Dec;138(6):1018-25; discussion 1025-6
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  • METHODS: Between 1998 and 2004, 190 patients with primary hyperparathyroidism underwent MIP with excision of a single adenoma.
  • Age, gender, race, prior head and neck surgery, use of preoperative thyroid hormone or calcium-channel blockers, preoperative levels of calcium, 25-hydroxyvitamin D (25[OH]D) and intact parathyroid hormone (iPTH), the presence of osteopenia or osteoporosis, intraoperative iPTH levels, and adenoma weight were evaluated by univariate analysis as predictors of postoperative symptoms of hypocalcemia and secondary hyperparathyroidism.
  • RESULTS: None of the following were predictors of postoperative symptoms of hypocalcemia: age, gender, race, prior head and neck surgery, preoperative medications, preoperative calcium and iPTH levels, osteopenia or osteoporosis, intraoperative iPTH levels, or adenoma weight.
  • [MeSH-major] Adenoma / blood. Hyperparathyroidism, Secondary / etiology. Hypocalcemia / etiology. Parathyroid Neoplasms / blood. Parathyroidectomy / adverse effects. Vitamin D / analogs & derivatives

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  • (PMID = 16360386.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 1406-16-2 / Vitamin D; 64719-49-9 / 25-hydroxyvitamin D
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45. Adsay NV: Cystic neoplasia of the pancreas: pathology and biology. J Gastrointest Surg; 2008 Mar;12(3):401-4
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  • In contrast, the rare cystic tumors that occur as a result of degenerative/necrotic changes in otherwise solid neoplasia such as the rare cystic ductal adenocarcinomas, cystic endocrine neoplasia, and most importantly, solid-pseudopapillary tumor (SPT) in which cystic change is so common that it used to be incorporated into its name ("solid-cystic," "papillary-cystic") are malignant neoplasia, albeit variable degrees of aggressiveness.
  • [MeSH-major] Adenoma / pathology. Carcinoma in Situ / pathology. Neoplasms, Cystic, Mucinous, and Serous / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology. Precancerous Conditions / pathology

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  • (PMID = 17957438.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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46. Fedele M, Pierantoni GM, Visone R, Fusco A: Critical role of the HMGA2 gene in pituitary adenomas. Cell Cycle; 2006 Sep;5(18):2045-8
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  • The molecular pathway leading to pituitary tumorigenesis is still largely unknown and is one of the challenges of the endocrine oncology.
  • Based on the mating between HMGA2 transgenic and E2F1 knockout mice, the activation of E2F1 appears to be the main mechanism of the onset of HMGA2-induced pituitary adenoma development.
  • [MeSH-major] Adenoma / genetics. Genetic Predisposition to Disease / genetics. HMGA2 Protein / genetics. Pituitary Neoplasms / genetics

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  • (PMID = 16969098.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / E2F1 Transcription Factor; 0 / E2F1 protein, human; 0 / HMGA2 Protein; EC 3.5.1.98 / HDAC1 protein, human; EC 3.5.1.98 / Histone Deacetylase 1; EC 3.5.1.98 / Histone Deacetylases
  • [Number-of-references] 29
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47. Hsiao HP, Kirschner LS, Bourdeau I, Keil MF, Boikos SA, Verma S, Robinson-White AJ, Nesterova M, Lacroix A, Stratakis CA: Clinical and genetic heterogeneity, overlap with other tumor syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors. J Clin Endocrinol Metab; 2009 Aug;94(8):2930-7
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  • 2) adrenocortical cortisol-producing adenoma with CS (n = 15);.
  • 3) aldosterone-producing adenoma (n = 19); and 4) single adenomas with clinically nonsignificant cortisol secretion (n = 32).

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  • (PMID = 19509103.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / Z01 HD000642; United States / NICHD NIH HHS / HD / Z01-HD-000642-04
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 7S5I7G3JQL / Dexamethasone; 9002-60-2 / Adrenocorticotropic Hormone; 9015-71-8 / Corticotropin-Releasing Hormone; EC 3.6.1.- / GNAS protein, human; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gs
  • [Other-IDs] NLM/ PMC2730864
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48. Comlekci A, Yener S, Ertilav S, Secil M, Akinci B, Demir T, Kebapcilar L, Bayraktar F, Yesil S, Eraslan S: Adrenal incidentaloma, clinical, metabolic, follow-up aspects: single centre experience. Endocrine; 2010 Feb;37(1):40-6
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  • Metabolic derangements were common; however, a possible independent association between adrenal adenoma and metabolic problems need to be elucidated with prospective studies.
  • [MeSH-minor] Adenoma / blood. Adenoma / physiopathology. Adenoma / therapy. Adenoma / urine. Adolescent. Adrenal Cortex Hormones / blood. Adrenal Cortex Hormones / urine. Adrenal Gland Neoplasms / blood. Adrenal Gland Neoplasms / physiopathology. Adrenal Gland Neoplasms / therapy. Adrenal Gland Neoplasms / urine. Adrenocorticotropic Hormone / blood. Adult. Aged. Aging. Cushing Syndrome / epidemiology. Female. Follow-Up Studies. Humans. Hypertension / epidemiology. Male. Metanephrine / urine. Middle Aged. Normetanephrine / urine. Prevalence. Retrospective Studies. Turkey / epidemiology. Young Adult

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  • (PMID = 19882253.001).
  • [ISSN] 1559-0100
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Chaychi L, Belbruno K, Golding A, Memoli V: Unusual manifestation of parathyroid carcinoma in the setting of papillary thyroid cancer. Endocr Pract; 2010 Jul-Aug;16(4):664-8
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  • To our knowledge, our current case is the first documented patient with parathyroid carcinoma who had a clinical presentation consistent with longstanding mild adenoma in addition to synchronous papillary thyroid carcinoma.
  • [MeSH-minor] Adenoma / blood. Adenoma / complications. Aged. Female. Humans. Hypercalcemia / blood. Thyroid Nodule / blood. Thyroid Nodule / complications


50. Doherty GM: Multiple endocrine neoplasia type 1. J Surg Oncol; 2005 Mar 1;89(3):143-50
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  • [Title] Multiple endocrine neoplasia type 1.
  • Multiple endocrine neoplasia-1 (MEN-1) is an autosomal dominant inherited syndrome that occurs due to inactivating mutations of the MEN1 gene locus, coding for a tumor-suppressor protein, menin.
  • [MeSH-major] Genes, Tumor Suppressor. Multiple Endocrine Neoplasia Type 1. Proto-Oncogene Proteins / genetics
  • [MeSH-minor] Adenoma / diagnosis. Endosonography. Female. Humans. Hyperparathyroidism / etiology. Insulinoma / radiography. Insulinoma / surgery. Male. Neuroectodermal Tumors / radiography. Neuroectodermal Tumors / radionuclide imaging. Pancreatic Neoplasms / radiography. Pancreatic Neoplasms / radionuclide imaging. Pancreatic Neoplasms / surgery. Parathyroid Neoplasms / diagnosis. Pituitary Neoplasms / surgery. Prolactinoma / surgery. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed. Vipoma / surgery


51. Miyoshi T, Otsuka F, Kawabata T, Inagaki K, Mukai T, Kawashima M, Ogura T, Yamamura M, Sei T, Makino H: Manifestation of rheumatoid arthritis after transsphenoidal surgery in a patient with acromegaly. Endocr J; 2006 Oct;53(5):621-5
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  • Here, we report a 70-year-old Japanese woman with acromegaly, who complained of bilateral finger stiffness and polyarthralgia two months after transsphenoidal surgery of a growth hormone (GH)-secreting pituitary adenoma.
  • [MeSH-minor] Adenoma / complications. Adenoma / radiography. Adenoma / surgery. Aged. Bone Marrow Diseases / complications. Bone Marrow Diseases / radiography. C-Reactive Protein / analysis. Female. Growth Hormone / blood. Growth Hormone-Secreting Pituitary Adenoma / complications. Growth Hormone-Secreting Pituitary Adenoma / radiography. Growth Hormone-Secreting Pituitary Adenoma / surgery. Hand / radiography. Humans. Synovitis / complications. Synovitis / radionuclide imaging


52. Paunovic I, Krgovic K, Tatic S, Diklic A, Zivaljevic V, Kalezic N, Havelka M: Surgery for thyroid Hürthle cell tumours--a single institution experience. Eur J Surg Oncol; 2006 May;32(4):458-61
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  • RESULTS: We identified 199 patients with Hürthle cell tumours (HCT), 88 patients with Hürthle cell carcinoma (HCC) and 111 patients with Hürthle cell adenoma (HCA).
  • [MeSH-major] Adenoma, Oxyphilic / surgery. Thyroid Neoplasms / surgery. Thyroidectomy / methods

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  • (PMID = 16497473.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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53. Ikeda H, Abe T, Watanabe K: Usefulness of composite methionine-positron emission tomography/3.0-tesla magnetic resonance imaging to detect the localization and extent of early-stage Cushing adenoma. J Neurosurg; 2010 Apr;112(4):750-5
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  • [Title] Usefulness of composite methionine-positron emission tomography/3.0-tesla magnetic resonance imaging to detect the localization and extent of early-stage Cushing adenoma.
  • OBJECT: Fifty to eighty percent of Cushing disease is diagnosed by typical endocrine responses.
  • Recently, the number of diagnoses of Cushing disease without typical Cushing syndrome has been increasing; therefore, improving ways to determine the localization of the adenoma and making an early diagnosis is important.
  • METHODS: During the past 3 years the authors analyzed the diagnostic accuracy in a series of 35 patients with Cushing adenoma that was verified by surgical pituitary exploration.
  • Moreover, the adenoma location was better delineated on MET-PET/MR images than on FDG-PET/MR images.
  • CONCLUSIONS: Composite MET-PET/3.0-T MR imaging is useful for the improvement of the delineation of Cushing microadenoma and offers high-quality detectability for early-stage Cushing adenoma.
  • [MeSH-major] ACTH-Secreting Pituitary Adenoma. Adenoma. Magnetic Resonance Imaging / methods. Pituitary ACTH Hypersecretion. Positron-Emission Tomography / methods


54. Tinnel BA, Henderson MA, Witt TC, Fakiris AJ, Worth RM, Des Rosiers PM, Edmondson JW, Timmerman RD, Lo SS: Endocrine response after gamma knife-based stereotactic radiosurgery for secretory pituitary adenoma. Stereotact Funct Neurosurg; 2008;86(5):292-6
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  • [Title] Endocrine response after gamma knife-based stereotactic radiosurgery for secretory pituitary adenoma.
  • For adrenocorticotrophic hormone-secreting tumors, 6 of 12 patients (50%) showed normalization of their endocrine levels at a median of 10 months.
  • For growth hormone-secreting tumors, 4 of 9 patients (44%) showed normalization of endocrine levels at a median time of 30 months.
  • Two patients (22%) had >or=50% lower but abnormal endocrine levels.
  • CONCLUSION: GK-based SRS provides a reasonable rate of endocrine normalization of secretory pituitary adenoma.
  • The time to endocrine response is shorter than reported for fractionated external beam radiotherapy.
  • [MeSH-minor] ACTH-Secreting Pituitary Adenoma / secretion. ACTH-Secreting Pituitary Adenoma / surgery. Adenoma / secretion. Adenoma / surgery. Adrenocorticotropic Hormone / secretion. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Growth Hormone-Secreting Pituitary Adenoma / secretion. Growth Hormone-Secreting Pituitary Adenoma / surgery. Human Growth Hormone / secretion. Humans. Hydrocortisone / blood. Insulin-Like Growth Factor I / metabolism. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18758206.001).
  • [ISSN] 1423-0372
  • [Journal-full-title] Stereotactic and functional neurosurgery
  • [ISO-abbreviation] Stereotact Funct Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I; 9002-60-2 / Adrenocorticotropic Hormone; 9002-62-4 / Prolactin; WI4X0X7BPJ / Hydrocortisone
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55. Melton GB, Somervell H, Friedman KP, Zeiger MA, Cahid Civelek A: Interpretation of 99mTc sestamibi parathyroid SPECT scan is improved when read by the surgeon and nuclear medicine physician together. Nucl Med Commun; 2005 Jul;26(7):633-8
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  • Scans were prospectively interpreted by an endocrine surgeon and nuclear medicine physician attending together (NMP+S) and a nuclear medicine physician attending alone (NMP alone).
  • The most common finding interpreted incorrectly by NMP alone and correctly by NMP+S was an ectopic superior parathyroid adenoma in the inferior position.
  • CONCLUSIONS: Parathyroid sestamibi SPECT scan interpretation by an endocrine surgeon reading with a nuclear medicine attending resulted in improved accuracy of gland localization and lateralization compared to a nuclear medicine attending reading alone.

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  • (PMID = 15942484.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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56. Wirowski D, Lammers BJ, Pohl P, Schwarz K, Goretzki PE: Does multiple gland disease in primary hyperparathyroidism correlate with age or sex? Langenbecks Arch Surg; 2009 Sep;394(5):885-90
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  • [MeSH-major] Adenoma / pathology. Hyperparathyroidism, Primary / etiology. Parathyroid Neoplasms / pathology

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  • [Cites] ANZ J Surg. 2006 Dec;76(12 ):1048-50 [17199687.001]
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  • (PMID = 19533167.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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57. Penezić Z, Zarković M, Vujović S, Cirić J, Beleslin B, Ivović M, Pokrajac A, Drezgić M: Gonadotropin pulsatility in Cushing's syndrome compared with polycystic ovary syndrome. Gynecol Endocrinol; 2005 Mar;20(3):150-4
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  • The first group comprised 12 females with clinically and biochemically proven CS, subsequently confirmed by histology (seven with Cushing's syndrome, five with adrenal adenoma).
  • The second group comprised ten females with clinical, endocrine and ultrasonographic parameters for PCOS, while the third group comprised ten healthy females with regular menstrual cycles to serve as controls.


58. Buchfelder M, Schlaffer S, Droste M, Mann K, Saller B, Brübach K, Stalla GK, Strasburger CJ, German Pegvisomant Observational Study: The German ACROSTUDY: past and present. Eur J Endocrinol; 2009 Nov;161 Suppl 1:S3-S10
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  • [Title] The German ACROSTUDY: past and present.
  • Pivotal studies have demonstrated that pharmacotherapy with pegvisomant (Somavert) is a highly effective treatment for acromegaly.
  • Since clinical experience with the drug was very limited, the Pegvisomant Observational Study was launched in Germany immediately with the drug becoming commercially available to patients early in 2004.
  • Its purpose was to record safety and efficacy data on as many patients as possible.
  • As of 12th August 2008 a total of 371 patients (185 males, 186 females) had been included in the study.
  • They were on pegvisomant therapy for an average of 118 weeks.
  • Median and mean doses of pegvisomant were 15 and 16.4 mg/day respectively.
  • Treatment efficacy was monitored by IGF1 levels and the patients symptoms were evaluated by completion of a questionnaire (patient-assessed acromegaly symptom questionnaire).
  • Safety data included liver function tests, fasting glucose, HbA1c measurements, and tumor size monitoring by repeated magnetic resonance imaging.
  • Normalization of IGF1 ranged from 55.7% of the 273 patients assessed after 6 months to 71.3% of 202 patients assessed after 24 months of treatment.
  • It was 70.7% after 36 months (133 patients), 64.8% at 48 months (71 patients), and 58.4% after 60 months (24 patients).
  • In 39 patients (10.9%) treatment was discontinued due to serious adverse events or adverse events with 25 (6.7%) of these patients having a potential causal relationship with the pegvisomant treatment.
  • Liver function tests became abnormal in 20 patients and another three patients were recorded to have hepatobiliary disorders.
  • Tumor size increase was reported in 20 patients, but only confirmed in nine patients by careful revision of all available images.
  • Local injection site reactions were observed in 12 patients.
  • In conclusion, in this large group of pegvisomant-treated patients, long-term data for up to 5 years of treatment are now available.
  • In 71.3% of patients with previously not sufficiently treatable acromegaly, IGF1 levels were normalized by pegvisomant therapy.
  • Elevated transaminases usually normalized after discontinuation but in half of the affected patients also despite continuation of treatment without dose alteration.
  • Tumor progression was a rare event.
  • It did not exceed the expected rate in patients with acromegaly not treated with pegvisomant.
  • As from this presently largest database of acromegalic patients treated with pegvisomant, long-term results are encouraging.
  • The German data are now merged into the global ACROSTUDY and will constitute a major portion of the international ACROSTUDY project as a continuing global web-based observational study.

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  • (PMID = 19684061.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Blood Glucose; 0 / Hemoglobin A, Glycosylated; 0 / Hormone Antagonists; 0 / Receptors, Somatotropin; 0 / pegvisomant; 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase
  • [Investigator] Droste M; Stalla GK; Allolio B; Faust M; Brendel M; Finke R; Tuchelt H; Bidlingmaier M; Engelbach M; Santen R; Hampel R; Mann K; Kann PH; Boehm B; Kasperk C; Helios CK; Wallaschofski H; Moenig H; Stumvoll M; Schopohl J; Völz B; Würl K; Ittner J; Reschke K; Jacobeit J; Ramadori G; Schindler A; Zeuzem S; Badenhoop K; Beil FU; Pfeiffer AF; Vogel C; Hofbauer LC; Strasburger CJ; Tuschy U; Plöckinger U; Seidlitz B; Demtröder F; Schmiegel; Gellner R; Gräf KJ; Schröder U; Ball P; Ventzke K; Hensen J; Lux H; Etzrodt H; Alexopoulos A; Spitzweg C; Schnabel D; Dost A; Weber MM; Wiemer K; Omran W; Keuser R; Salzgeber K; Gutekunst R; Terkamp C; Gaissmaier S; Eversmann T; Seufert J; Jaursch-Hancke C; Ritter M; Undeutsch C; Jochum E; Mutterhaus der Borromäerinnen S; Schleiffer T; Karges W; Meuser J; Wildbrett J; Krug J; Buchfelder M; Klingmüller D; Schmitz U; Perras B; Zick R; Leicht E; Manfras B; Schuppert F; Müller OA; Stahmer E; Kajdan U; Gallwitz; Rochlitz H; Heckmann C; Haak E; Weber R; Herrmann BL; Schneider S; Scherbaum WA; Deuss U; Jacobs B; Gerbert B; Wolf M; West T; Lippe J; Biering H
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59. Pollock BE, Jacob JT, Brown PD, Nippoldt TB: Radiosurgery of growth hormone-producing pituitary adenomas: factors associated with biochemical remission. J Neurosurg; 2007 May;106(5):833-8
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  • CONCLUSIONS: Discontinuation of pituitary suppressive medications at least 1 month before radiosurgery significantly improved endocrine outcomes for patients with acromegaly.
  • [MeSH-major] Acromegaly / surgery. Growth Hormone-Secreting Pituitary Adenoma / surgery. Human Growth Hormone / blood. Pituitary Neoplasms / surgery. Postoperative Complications / diagnosis. Radiosurgery

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  • (PMID = 17542527.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I
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60. Parenti G, Nassi R, Silvestri S, Bianchi S, Valeri A, Manca G, Mangiafico S, Ammannati F, Serio M, Mannelli M, Peri A: Multi-step approach in a complex case of Cushing's syndrome and medullary thyroid carcinoma. J Endocrinol Invest; 2006 Feb;29(2):177-81
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  • In particular, in ACTH-dependent CS it may be difficult to distinguish between the presence of an ACTH-secreting pituitary adenoma and ectopic ACTH and/or CRH secretion.
  • We report here the case of a 54-yr-old man affected by ACTH-dependent CS in association with a left adrenal adenoma and medullary thyroid carcinoma (MTC).

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  • (PMID = 16610247.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 9007-12-9 / Calcitonin
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61. Freedman RJ, Malkovska V, LeRoith D, Collins MT: Hodgkin lymphoma in temporal association with growth hormone replacement. Endocr J; 2005 Oct;52(5):571-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma / therapy. Adult. Female. Humans. Middle Aged. Pituitary Neoplasms / therapy

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  • (PMID = 16284435.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone
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62. Ozcan-Kara P, Mahmoudian B, Erbas B, Erbas T: McCune-Albright syndrome associated with acromegaly and bipolar affective disorder. Eur J Intern Med; 2007 Dec;18(8):600-2
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  • This syndrome is characterized by polyostotic fibrous dysplasia, café-au-lait pigmentation, and multiple endocrine hyperfunction.
  • A 29-year-old male with polyostotic fibrous dysplasia, café-au-lait pigmentations, and pituitary adenoma is presented in this report.

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  • (PMID = 18054713.001).
  • [ISSN] 0953-6205
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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63. Tateno T, Izumiyama H, Doi M, Akashi T, Ohno K, Hirata Y: Defective expression of prohormone convertase 1/3 in silent corticotroph adenoma. Endocr J; 2007 Dec;54(5):777-82
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  • [Title] Defective expression of prohormone convertase 1/3 in silent corticotroph adenoma.
  • Silent corticotroph adenoma (SCA) is defined as an ACTH-producing pituitary tumor not associated with clinical and endocrine feartures of Cushing's syndrome, but its underlying molecular mechanism(s) remains unknown thus far.
  • Preoperative endocrine and diagnostic image tests did not reveal any differences between SCA and the remaining NFA except for the higher recurrence rate of SCA.
  • [MeSH-major] ACTH-Secreting Pituitary Adenoma / genetics. Adenoma / genetics. Proprotein Convertase 1 / genetics

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  • (PMID = 17917309.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Protein Isoforms; 66796-54-1 / Pro-Opiomelanocortin; 9002-60-2 / Adrenocorticotropic Hormone; EC 3.4.21.93 / Proprotein Convertase 1
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64. Das K, Stone N, Kendall C, Fowler C, Christie-Brown J: Role of Fourier transform infrared spectroscopy (FTIR) in the diagnosis of parathyroid pathology. Photodiagnosis Photodyn Ther; 2007 Jun;4(2):124-9
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  • To resolve this issue we evaluated the ability of FTIR to accurately differentiate between parathyroid adenoma and hyperplasia using their biochemical signatures.

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  • (PMID = 25047346.001).
  • [ISSN] 1572-1000
  • [Journal-full-title] Photodiagnosis and photodynamic therapy
  • [ISO-abbreviation] Photodiagnosis Photodyn Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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65. Qu QY, Zhang QH, Wang XY: [Expression of E-cadherin catenin complex and invasiveness of pituitary adenoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Jun;41(6):433-6
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  • [Title] [Expression of E-cadherin catenin complex and invasiveness of pituitary adenoma].
  • OBJECTIVE: To explore the relationship between the E-cadherin catenin complex and invasiveness of pituitary adenoma.
  • METHODS: The expression of E-cadherin catenin complex was determined by immunohistochemistry in 78 cases of human pituitary adenomas including invasive adenoma 44 cases, noninvasive adenoma 34 cases and the relativity of their expressions with hormone-producing, pituitary apoplexy and necrosis or cystoid change, tumor diameter were analyzed.
  • Moreover, the expressions of beta-cad and alpha-cat were significantly lower in macro-adenoma group than that in micro-adenoma group (chi-squared = 5.038, P < 0.05).
  • The expression of E-cad was significantly lower in endocrine inactive group than that in endocrine active group (chi-squared = 4.614, P < 0.05).

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  • (PMID = 16927799.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cadherins; 0 / alpha Catenin; 0 / beta Catenin
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66. Jastania RA, Alsaad KO, Al-Shraim M, Kovacs K, Asa SL: Double adenomas of the pituitary: transcription factors Pit-1, T-pit, and SF-1 identify cytogenesis and differentiation. Endocr Pathol; 2005;16(3):187-94
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  • [MeSH-major] Adenoma / metabolism. Homeodomain Proteins / biosynthesis. Neoplasms, Second Primary / metabolism. Pituitary Neoplasms / metabolism. Receptors, Cytoplasmic and Nuclear / biosynthesis. Transcription Factor Pit-1 / biosynthesis. Transcription Factors / biosynthesis

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  • (PMID = 16299401.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Steroidogenic Factor 1; 0 / T-Box Domain Proteins; 0 / TBX19 protein, human; 0 / Transcription Factor Pit-1; 0 / Transcription Factors
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67. Târcoveanu E, Moldovanu R, Georgescu S, Niculescu D, Lupaşcu C, Dimofte G: [Pancreatic endocrine tumors]. Chirurgia (Bucur); 2006 Mar-Apr;101(2):175-81
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  • [Title] [Pancreatic endocrine tumors].
  • [Transliterated title] Tumori pancreatice endocrine.
  • Incidence of the endocrine tumors of the pancreas is about 4 to 10/1.000.000 peoples.
  • We present 10 cases of endocrine pancreatic tumors which were operated in the First Surgical Clinic Iaşi in the last 20 years (1984-2003); these cases represent about 2.21% from all the pancreatic tumors (454 cases).
  • It was 4 insulinoma, 2 gastrinoma, 2 gastrinoma associated with other endocrine neoplasia (Wermer syndrome) and 2 non-functioning endocrine pancreatic tumors.
  • Both patients died and diagnosis of pancreatic endocrine tumors was post-mortem.
  • The two patients with Wermer syndrome also had ulcers complicated with haemorrhage and peritonitis and parathyroid adenoma.
  • One case also had ante-hypophyseal and pituitary adenoma and the other had thyroid colloid hypertrophy.
  • The two cases of non-functioning pancreatic endocrine tumors had a non-specific symptoms.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Medical Records. Middle Aged. Multiple Endocrine Neoplasia Type 1 / diagnosis. Pancreatectomy. Retrospective Studies. Romania. Splenectomy. Survival Analysis. Zollinger-Ellison Syndrome / diagnosis

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  • (PMID = 16752684.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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68. Ouaïssi M, Sielezneff I, Alves A, Pirro N, Heyries L, Robitail S, Consentino B, Payan MJ, Valleur P, Panis Y, Sastre B: [Long term outcome following 26 surgical ampullectomies]. Ann Chir; 2006 May;131(5):322-7
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  • RESULTS: Final pathological examination revealed 15 adenomas, 4 in situ adenocarcinomas, 2 endocrine tumors, and 5 other benign lesions.
  • [MeSH-minor] Adenocarcinoma / surgery. Adenoma / surgery. Adenomatous Polyposis Coli / surgery. Adult. Aged. Carcinoma in Situ / surgery. Cause of Death. Common Bile Duct Diseases / surgery. Female. Follow-Up Studies. Granuloma, Plasma Cell / surgery. Humans. Longitudinal Studies. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Retrospective Studies. Somatostatinoma / surgery. Survival Rate. Treatment Outcome

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  • (PMID = 16615931.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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69. DiGiovanni R, Serra S, Ezzat S, Asa SL: AIP Mutations are not identified in patients with sporadic pituitary adenomas. Endocr Pathol; 2007;18(2):76-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / metabolism. Pituitary Neoplasms / metabolism. Proteins / metabolism

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  • (PMID = 17916996.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Rocque BG, Herold KA, Salamat MS, Shenker Y, Kuo JS: Symptomatic hyperprolactinemia from an ectopic pituitary adenoma located in the clivus. Endocr Pract; 2009 Mar;15(2):143-8
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  • [Title] Symptomatic hyperprolactinemia from an ectopic pituitary adenoma located in the clivus.
  • OBJECTIVE: To report a case of an ectopic pituitary adenoma in the clivus.
  • After the resected tissue was examined, the patient was diagnosed as having an ectopic prolactin-producing pituitary adenoma.

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  • (PMID = 19289326.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Takenaka Y, Tsukamoto T, Mizoshita T, Ogasawara N, Hirano N, Otsuka T, Ban H, Nakamura T, Yamamura Y, Kaminishi M, Tatematsu M: Gastric and intestinal phenotypic correlation between exocrine and endocrine components in human stomach tumors. Histol Histopathol; 2007 03;22(3):273-84
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  • [Title] Gastric and intestinal phenotypic correlation between exocrine and endocrine components in human stomach tumors.
  • To clarify whether our hypothesis is correct or not, we analyzed the expression of Exo-cell and endocrine cell (End-cell) markers in a series of lesions for comparison.
  • We evaluated chromogranin A (CgA) expression in 37 early and 73 advanced stomach cancers, in 30 stomach adenomas, in 8 carcinoid tumors, and in 4 endocrine cell carcinomas (ECCs) with assessment of gastric and/or intestinal (G/I) phenotypes in both Exo-cell and End-cell by immunohistochemistry.
  • All of the adenoma cases had the intestinal Exo-cell phenotypic expression, with the positive link between Exo-cell and End-cell G/I phenotypes.
  • [MeSH-major] Adenocarcinoma / secondary. Adenoma / pathology. Biomarkers, Tumor / metabolism. Carcinoid Tumor / pathology. Neoplasm Proteins / metabolism. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Cell Count. Chromogranin A / metabolism. Endocrine Glands / metabolism. Endocrine Glands / pathology. Exocrine Glands / metabolism. Exocrine Glands / pathology. Female. Gastric Mucosa / metabolism. Gastric Mucosa / pathology. Humans. Intestinal Mucosa / metabolism. Intestinal Mucosa / pathology. Lymphatic Metastasis / pathology. Male. Middle Aged. Phenotype

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  • (PMID = 17163401.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / Neoplasm Proteins
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72. Fajardo-Montañana C, Daly AF, Riesgo-Suárez P, Gómez-Vela J, Tichomirowa MA, Camara-Gómez R, Beckers A: [AIP mutations in familial and sporadic pituitary adenomas: local experience and review of the literature]. Endocrinol Nutr; 2009 Aug-Sep;56(7):369-77
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  • The majority are isolated cases, but their presentation can be familial in the setting of known syndromes such as multiple endocrine neoplasia (MEN)-1 and Carney complex.
  • [MeSH-major] Adenoma / genetics. Intracellular Signaling Peptides and Proteins / genetics. Mutation. Pituitary Neoplasms / genetics

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  • (PMID = 19883897.001).
  • [ISSN] 1575-0922
  • [Journal-full-title] Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición
  • [ISO-abbreviation] Endocrinol Nutr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / aryl hydrocarbon receptor-interacting protein
  • [Number-of-references] 26
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73. Ingui CJ, Shah NP, Oates ME: Endocrine neoplasm scintigraphy: added value of fusing SPECT/CT images compared with traditional side-by-side analysis. Clin Nucl Med; 2006 Nov;31(11):665-72
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  • [Title] Endocrine neoplasm scintigraphy: added value of fusing SPECT/CT images compared with traditional side-by-side analysis.
  • This study explores the added value of SPECT/CT image fusion compared with traditional "side-by-side" SPECT/CT image review for a variety of endocrine neoplasms.
  • METHODS AND MATERIALS: We identified 11 abnormal endocrine neoplasm SPECT scans in 10 patients with contemporary relevant CT scans.
  • These cases included: 4 I-131 (posttherapy thyroid cancer), 2 I-123 (pretherapy thyroid cancer), 2 In-111 OctreoScan (neuroendocrine neoplasm), one Tc-99m sestamibi (thyroid cancer), one Tc-99m tetrofosmin (parathyroid adenoma), and one I-123 MIBG (adrenergic neoplasm).
  • CONCLUSIONS: CT correlation can be helpful in interpreting endocrine neoplasm SPECT imaging.
  • [MeSH-major] Endocrine Gland Neoplasms / diagnosis. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Subtraction Technique. Tomography, Emission-Computed, Single-Photon / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 17053381.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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74. Ozturk M, Chiu CY, Akdeniz N, Jenq SF, Chang SC, Hsa CY, Jap TS: Two novel mutations in the MEN1 gene in subjects with multiple endocrine neoplasia-1. J Endocrinol Invest; 2006 Jun;29(6):523-7
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  • [Title] Two novel mutations in the MEN1 gene in subjects with multiple endocrine neoplasia-1.
  • Multiple endocrine neoplasia type 1 (MEN1) is characterized by parathyroid, enteropancreatic endocrine and pituitary adenomas as well as germline mutation of the MEN1 gene.
  • [MeSH-major] Multiple Endocrine Neoplasia Type 1 / genetics. Mutation, Missense. Proto-Oncogene Proteins / genetics
  • [MeSH-minor] Adenoma / genetics. Adolescent. Adult. Aged. Amino Acid Sequence. Child. Child, Preschool. DNA Mutational Analysis. Female. Humans. Hyperparathyroidism, Primary / genetics. Male. Middle Aged. Parathyroid Neoplasms / genetics. Pituitary Neoplasms / genetics. Prolactinoma / genetics. Taiwan. Turkey

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  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
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75. Gursoy A, Anil C, Unal AD, Demirer AN, Tutuncu NB, Erdogan MF: Clinical and epidemiological characteristics of thyroid hemiagenesis: ultrasound screening in patients with thyroid disease and normal population. Endocrine; 2008 Jun;33(3):338-41
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  • The underlying thyroid diseases were Hashimoto's thyroiditis (n = 4), euthyroid multinodular goiter (n = 4), and toxic adenoma (n = 1).
  • [MeSH-minor] Adenoma / diagnostic imaging. Adenoma / epidemiology. Adolescent. Adult. Aged. Aged, 80 and over. Child. Databases, Factual. Female. Goiter, Nodular / diagnostic imaging. Goiter, Nodular / epidemiology. Hashimoto Disease / diagnostic imaging. Hashimoto Disease / epidemiology. Health Surveys. Humans. Male. Mass Screening. Middle Aged. Prevalence. Sex Distribution. Thyroid Neoplasms / diagnostic imaging. Thyroid Neoplasms / epidemiology. Ultrasonography. Young Adult

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  • (PMID = 19016002.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Goasguen N, Chirica M, Roger N, Munoz-Bongrand N, Zohar S, Noullet S, de Roquancourt A, Cattan P, Sarfati E: Primary hyperparathyroidism from parathyroid microadenoma: specific features and implications for a surgical strategy in the era of minimally invasive parathyroidectomy. J Am Coll Surg; 2010 Apr;210(4):456-62
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  • STUDY DESIGN: Parathyroid microadenomas (weight < 100 mg) were identified in 62 (6%) of the 1,012 patients operated on for a parathyroid adenoma between 1995 and 2004.
  • Presentation and outcomes after surgery were compared with those of 124 patients operated on consecutively for parathyroid adenoma (>100 mg) during the last year of the study.
  • There was no difference in the clinical presentation between patients with microadenoma and adenoma.
  • Preoperative calcium (p < 0.001) and PTH serum levels (p = 0.014) were significantly higher in patients with adenoma.
  • Success rates were similar in the microadenoma and adenoma groups (92% vs 98%; p = 0.11).
  • [MeSH-major] Adenoma / complications. Adenoma / surgery. Hyperparathyroidism, Primary / etiology. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods

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  • [Copyright] Copyright (c) 2010 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] J Am Coll Surg. 2010 Sep;211(3):436-7; author reply 437-8 [20800204.001]
  • (PMID = 20347738.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
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77. Das K, Stone N, Kendall C, Fowler C, Christie-Brown J: Raman spectroscopy of parathyroid tissue pathology. Lasers Med Sci; 2006 Dec;21(4):192-7
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  • Primary hyperparathyroidism (HPT) in 80% of patients is due to a solitary parathyroid adenoma, while in 20% multigland pathology exists, usually hyperplasia [Scott-Coombes, Surgery, 21(12):309-312, 2003].

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  • (PMID = 17024320.001).
  • [ISSN] 0268-8921
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78. Jain R, Fischer S, Serra S, Chetty R: The use of Cytokeratin 19 (CK19) immunohistochemistry in lesions of the pancreas, gastrointestinal tract, and liver. Appl Immunohistochem Mol Morphol; 2010 Jan;18(1):9-15
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  • It is recommended that CK19 be part of the immunohistochemical panel in the work-up of pancreatic endocrine tumors.
  • It can also be used to highlight native ductules in the liver and helps separate conditions such as focal nodular hyperplasia from hepatic adenoma.

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  • (PMID = 19956064.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-19; 0 / Neoplasm Proteins
  • [Number-of-references] 51
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79. Hubina E, Góth M, Korbonits M: [Ghrelin--a hormone with multiple functions]. Orv Hetil; 2005 Jun 19;146(25):1345-51
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  • Ghrelin was originally identified from the stomach but it is also present in all tissue among others in: hypothalamus, pituitary, pancreas, lung, immune cells, placenta, ovary, testis, kidney and in different tumours including pituitary adenoma, neuroendocrine tumours, thyroid carcinomas, endocrine tumours of the pancreas and lung.

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  • (PMID = 16106757.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Ghrelin; 0 / Peptide Hormones
  • [Number-of-references] 52
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80. Sinnott BP, Hatipoglu B, Sarne DH: Intrasellar plasmacytoma presenting as a non-functional invasive pituitary macro-adenoma: case report & literature review. Pituitary; 2006;9(1):65-72
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  • [Title] Intrasellar plasmacytoma presenting as a non-functional invasive pituitary macro-adenoma: case report & literature review.
  • We report an uncommon case of an intrasellar plasmacytoma presenting as a non-functional invasive pituitary macro-adenoma as the first manifestation of multiple myeloma.
  • A 57 year old woman was referred to our department with a presumed diagnosis of a non-functioning pituitary macro-adenoma.
  • Preoperative endocrine evaluation was remarkable only for a modestly elevated serum prolactin.
  • Review of the world literature revealed only 22 previous reports of patients in whom a solitary plasmacytoma or multiple myeloma first presented as a sellar mass; in all cases mimicking clinically and radiologically a non-functioning invasive pituitary adenoma however with additional cranial nerve involvement.
  • [MeSH-major] Adenoma / diagnosis. Pituitary Neoplasms / diagnosis. Plasmacytoma / diagnosis. Plasmacytoma / surgery

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  • (PMID = 16703411.001).
  • [ISSN] 1386-341X
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] ENR1LLB0FP / Deamino Arginine Vasopressin
  • [Number-of-references] 42
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81. Raica M, Coculescu M, Cimpean AM, Ribatti D: Endocrine gland derived-VEGF is down-regulated in human pituitary adenoma. Anticancer Res; 2010 Oct;30(10):3981-6
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  • [Title] Endocrine gland derived-VEGF is down-regulated in human pituitary adenoma.
  • BACKGROUND: Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an angiogenic molecule restricted to endocrine glands and, particularly, to steroid-secreting cells.
  • MATERIALS AND METHODS: In this study, we investigated by immunohistochemistry the expression of EG-VEGF in 2 samples of normal adenohypophysis and 43 bioptic samples of pituitary adenoma.
  • RESULTS: The results of this study for the first time demonstrate a down-regulation of EG-VEGF expression in human pituitary adenoma as compared to normal adenohypophysis, suggesting an impaired function of the neoplastic cells in terms of hormone release in the blood stream, as a consequence of impaired tumor angiogenesis in the tumor.
  • CONCLUSION: On the basis of our data showing a marked decrease in the expression of EG-VEGF in pituitary adenoma, with the exception of LH-secreting adenomas, we suggest that LH might be involved in the induction of EG-VEGF secretion.
  • [MeSH-major] Adenoma / metabolism. Pituitary Neoplasms / metabolism. Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / biosynthesis

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  • (PMID = 21036711.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor, Endocrine-Gland-Derived; 12629-01-5 / Human Growth Hormone; 9002-60-2 / Adrenocorticotropic Hormone; 9002-62-4 / Prolactin; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone; 9002-71-5 / Thyrotropin
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82. Livingston CD, Victor B, Askew R, Abikhalid J, Meynig J, Lindsey M, Jones L: Surgeon-performed ultrasonography as an adjunct to minimally invasive radio-guided parathyroidectomy in 100 consecutive patients with primary hyperparathyroidism. Endocr Pract; 2008 Jan-Feb;14(1):28-32
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  • OBJECTIVE: To examine whether surgeon-performed ultrasonography (SPU) in patients with primary hyperparathyroidism and negative preoperative sestamibi scans improves adenoma localization, increases the directed unilateral exploration rate, and reduces operative time and length of hospital stay.
  • In sestamibi scan-negative patients, unilateral exploration was performed with removal of the adenoma, which was submitted for frozen section.
  • Parathyroid adenoma was localized in 17 (94%) of the 18 patients.
  • [MeSH-minor] Adenoma / complications. Adenoma / diagnosis. Adenoma / surgery. Cohort Studies. Female. Humans. Intraoperative Period. Length of Stay. Male. Middle Aged. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / surgery. Retrospective Studies. Technetium Tc 99m Sestamibi. Time Factors

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  • (PMID = 18238738.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 971Z4W1S09 / Technetium Tc 99m Sestamibi
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83. Mishra AK, Agarwal A, George RK, Gupta S, Mishra SK: Laparoscopic adrenalectomy for Conn's syndrome: report of the initial six cases. Int Surg; 2009 Jan-Feb;94(1):31-4
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  • From 1997 to 2002, 6 patients with primary hyperaldosteronism (Conn's syndrome) were referred to the Department of Endocrine Surgery and underwent laparoscopic adrenalectomy through the transperitoneal approach.
  • In all patients, the adrenal gland and the adenoma were successfully removed laparoscopically, and all patients were normokalemic and normotensive in the first follow-up after 6 months.

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  • (PMID = 20099423.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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84. Boguszewski CL, Bianchet LC, Raskin S, Nomura LM, Borba LA, Cavalcanti TC: Application of genetic testing to define the surgical approach in a sporadic case of multiple endocrine neoplasia type 1. Arq Bras Endocrinol Metabol; 2010 Nov;54(8):705-10
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  • [Title] Application of genetic testing to define the surgical approach in a sporadic case of multiple endocrine neoplasia type 1.
  • Parathyroid scintigraphy showed tracer uptake in the inferior region of the left thyroid lobe, and cervical ultrasound showed a heterogeneous nodule in the same area, suggestive of a parathyroid adenoma (PA).
  • [MeSH-major] Adenoma / genetics. Genetic Testing / standards. Hyperparathyroidism, Primary / genetics. Multiple Endocrine Neoplasia Type 1 / genetics. Parathyroid Neoplasms / genetics


85. Lal A, Chen H: The negative sestamibi scan: is a minimally invasive parathyroidectomy still possible? Ann Surg Oncol; 2007 Aug;14(8):2363-6
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  • RESULTS: Of the 90 patients, 60 (67%) had a single adenoma, 17 (19%) double adenomas and 13 (14%) 3- to 4-gland hyperplasias.
  • Accordingly, minimally invasive techniques were attempted in these 47 patients; 42 (89%) had single adenomas and in 5 the technique was converted to bilateral exploration for double adenoma/hyperplasia.
  • CONCLUSION: In patients with primary HPT and a negative sestamibi scan, most patients (67%) will have a single adenoma.
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Cohort Studies. Female. Humans. Hyperplasia / pathology. Hyperplasia / surgery. Male. Middle Aged. Radiopharmaceuticals. Retrospective Studies. Treatment Outcome

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  • (PMID = 17522941.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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86. Toledo RA, Lourenço DM Jr, Toledo SP: Familial isolated pituitary adenoma: evidence for genetic heterogeneity. Front Horm Res; 2010;38:77-86
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  • [Title] Familial isolated pituitary adenoma: evidence for genetic heterogeneity.
  • The identification of mutations in the Aryl hydrocarbon receptor interacting protein (AIP) gene in a subset of familial isolated pituitary adenoma (FIPA) cases has recently expanded our understanding of the pathophysiology of inherited pituitary adenoma disorders.
  • [MeSH-major] Adenoma / genetics. Genetic Heterogeneity. Pituitary Neoplasms / genetics

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  • [Copyright] Copyright (c) 2010 S. Karger AG, Basel.
  • (PMID = 20616498.001).
  • [ISSN] 0301-3073
  • [Journal-full-title] Frontiers of hormone research
  • [ISO-abbreviation] Front Horm Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / CDKN1B protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / aryl hydrocarbon receptor-interacting protein; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
  • [Number-of-references] 41
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87. Bergamaschi S, Ronchi CL, Giavoli C, Ferrante E, Verrua E, Ferrari DI, Lania A, Rusconi R, Spada A, Beck-Peccoz P: Eight-year follow-up of a child with a GH/prolactin-secreting adenoma: efficacy of pegvisomant therapy. Horm Res Paediatr; 2010;73(1):74-9
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  • [Title] Eight-year follow-up of a child with a GH/prolactin-secreting adenoma: efficacy of pegvisomant therapy.
  • The adenoma was surgically removed and histological characterization confirmed the diagnosis of GH/PRL-secreting adenoma.
  • The patient was admitted to our Endocrine Unit when 7.9 years old, because of the persistence of elevated GH, IGF-I and PRL levels, although there was a slight height velocity reduction and absence of tumor recurrence.
  • [MeSH-major] Adenoma / drug therapy. Growth Hormone-Secreting Pituitary Adenoma / drug therapy. Human Growth Hormone / analogs & derivatives. Pituitary Neoplasms / drug therapy. Prolactinoma / drug therapy

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  • (PMID = 20190543.001).
  • [ISSN] 1663-2826
  • [Journal-full-title] Hormone research in pædiatrics
  • [ISO-abbreviation] Horm Res Paediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Hormone Antagonists; 0 / pegvisomant; 12629-01-5 / Human Growth Hormone
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88. Paisley AN, Drake WM: Treatment of pituitary tumors: pegvisomant. Endocrine; 2005 Oct;28(1):111-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / drug therapy. Human Growth Hormone / analogs & derivatives. Pituitary Neoplasms / drug therapy

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  • (PMID = 16311417.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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  • [Number-of-references] 22
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89. Björklund P, Lindberg D, Akerström G, Westin G: Stabilizing mutation of CTNNB1/beta-catenin and protein accumulation analyzed in a large series of parathyroid tumors of Swedish patients. Mol Cancer; 2008;7:53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / genetics. Gene Expression Regulation, Neoplastic. Mutation. Parathyroid Neoplasms / genetics. beta Catenin / genetics

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  • (PMID = 18541010.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / beta Catenin
  • [Other-IDs] NLM/ PMC2435117
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90. Bricaire L, Brue T: [Familial pituitary adenomas: clinical and genetic aspects]. Ann Endocrinol (Paris); 2007 Jun;68 Suppl 1:9-11
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  • In multiple endocrine neoplasia type 1, they often associate with a mutation of the menin gene, a tumor-suppressing gene.
  • A new germinal mutation predisposing to the development of multiple endocrine neoplasias has recently been identified in MENI-negative subjects on the gene CDKN1B encoding for p27(kip1)protein.
  • Isolated familial pituitary adenomas represent 1.9 to 3.2% of the population of subjects presenting a pituitary adenoma.
  • Low penetrance non-sense mutations, Q14X, IVS3-IG>A and R304X, in 11q12-11q13 region encoding AIP protein, (Aryl hydrocarbon receptor Interacting Protein), have been described by Vierimaa et al, in Finish patients with pituitary adenoma predispositions.
  • [MeSH-major] Adenoma / genetics. Genetic Predisposition to Disease. Pituitary Neoplasms / genetics
  • [MeSH-minor] Humans. Multiple Endocrine Neoplasia Type 1 / genetics. Mutation. Receptors, Aryl Hydrocarbon / genetics


91. Georges CG, Guthoff M, Wehrmann M, Teichmann R, Gröne E, Artunc F, Risler T, Friedrich B, Müssig K: [Hypercalcaemic crisis and acute renal failure due to primary hyperparathyroidism]. Dtsch Med Wochenschr; 2008;133(Suppl 0):F3
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  • Hypercalcaemic crisis is a rare endocrine emergency.
  • Endocrine work-up revealed primary hyperparathyroidism due to a parathyroid adenoma, which was treated by emergency surgery.
  • [MeSH-minor] Adenoma / complications. Adenoma / diagnosis. Adenoma / surgery. Diphosphonates / therapeutic use. Emergencies. Female. Fluid Therapy. Humans. Middle Aged. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / surgery. Renal Dialysis / methods

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  • [CommentIn] Dtsch Med Wochenschr. 2009 Jan;134(5):211; author reply 212 [19180412.001]
  • (PMID = 19065508.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Diphosphonates; 114084-78-5 / ibandronic acid
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92. Carroll NM, Carty SE: Promising molecular techniques for discriminating among follicular thyroid neoplasms. Surg Oncol; 2006 Aug;15(2):59-64
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  • To guide the extent of thyroidectomy for indeterminate follicular neoplasm (FN), clinicians have long sought ways to differentiate follicular adenoma from carcinoma pre- or intraoperatively.
  • [MeSH-major] Adenocarcinoma, Follicular / blood. Adenocarcinoma, Follicular / diagnosis. Adenoma / blood. Adenoma / diagnosis. Thyroid Neoplasms / blood. Thyroid Neoplasms / diagnosis

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  • (PMID = 16949814.001).
  • [ISSN] 0960-7404
  • [Journal-full-title] Surgical oncology
  • [ISO-abbreviation] Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 59
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93. Schittenhelm J, Psaras T, Honegger J, Trautmann K, Meyermann R, Beschorner R: No evidence for WT1 involvement in a beta-catenin-independent activation of the Wnt signaling pathway in pituitary adenomas. Endocr Pathol; 2009;20(3):158-62
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  • Only two GHomas (including one atypical adenoma) and one gonadotropin-producing adenoma expressed WT1 in the cytoplasm of single tumor cells without nuclear staining.
  • [MeSH-major] Adenoma / metabolism. Pituitary Neoplasms / metabolism. Signal Transduction / physiology. WT1 Proteins / biosynthesis. beta Catenin / metabolism

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94. Minematsu T, Miyai S, Kajiya H, Suzuki M, Sanno N, Takekoshi S, Teramoto A, Osamura RY: Recent progress in studies of pituitary tumor pathogenesis. Endocrine; 2005 Oct;28(1):37-41
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  • [MeSH-major] Adenoma / etiology. Pituitary Neoplasms / etiology

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  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
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  • [Number-of-references] 43
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95. Türemen EE, Arslan BC, Tarkun I, Cantürk Z: Cushingoid striae and facial appearance in a patient with an adrenal incidentaloma. Endocr Pract; 2006 Jan-Feb;12(1):103-4
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  • [MeSH-major] Adenoma / pathology. Adrenal Gland Neoplasms / diagnosis. Cushing Syndrome / diagnosis. Pituitary Neoplasms / pathology

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  • (PMID = 16524866.001).
  • [ISSN] 1530-891X
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone
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96. Bai X, Li N, Wang F, Li S, Yu Q: Primary ovarian trabecular carcinoid tumor: a case report and literature review. Arch Gynecol Obstet; 2010 Oct;282(4):407-11
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  • INTRODUCTION: Carcinoid tumors are uncommon neoplasms in the diffuse peripheral endocrine system.
  • [MeSH-major] Adenoma / pathology. Carcinoid Tumor / pathology. Neoplasms, Glandular and Epithelial / pathology. Ovarian Neoplasms / pathology


97. de Bruin C, Feelders RA, Lamberts SW, Hofland LJ: Somatostatin and dopamine receptors as targets for medical treatment of Cushing's Syndrome. Rev Endocr Metab Disord; 2009 Jun;10(2):91-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] ACTH-Secreting Pituitary Adenoma / drug therapy. Adrenocorticotropic Hormone / metabolism. Animals. Antineoplastic Agents / therapeutic use. Humans

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  • (PMID = 18642088.001).
  • [ISSN] 1573-2606
  • [Journal-full-title] Reviews in endocrine & metabolic disorders
  • [ISO-abbreviation] Rev Endocr Metab Disord
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Receptors, Dopamine D2; 0 / Receptors, Somatostatin; 9002-60-2 / Adrenocorticotropic Hormone
  • [Number-of-references] 115
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98. Lewis RB, Lattin GE Jr, Paal E: Pancreatic endocrine tumors: radiologic-clinicopathologic correlation. Radiographics; 2010 Oct;30(6):1445-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreatic endocrine tumors: radiologic-clinicopathologic correlation.
  • Pancreatic endocrine tumors (PETs) are primarily well-differentiated tumors composed of cells that resemble normal islet cells but that arise from pancreatic ductal cells.
  • Most are sporadic, but some are associated with familial syndromes such as multiple endocrine neoplasia type 1, von Hippel-Lindau syndrome, and neurofibromatosis type 1.
  • [MeSH-minor] Adenoma, Islet Cell / diagnosis. Adenoma, Islet Cell / epidemiology. Adenoma, Islet Cell / pathology. Carcinoma, Islet Cell / diagnosis. Carcinoma, Islet Cell / epidemiology. Carcinoma, Islet Cell / pathology. Diagnosis, Differential. Humans. Multiple Endocrine Neoplasia Type 1 / pathology. Neurofibromatosis 1 / pathology. Prevalence. von Hippel-Lindau Disease / pathology

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  • [Copyright] © RSNA, 2010.
  • (PMID = 21071369.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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99. Courcoutsakis N, Patronas N, Filie AC, Carney JA, Moraitis A, Stratakis CA: Ectopic thymus presenting as a thyroid nodule in a patient with the Carney complex. Thyroid; 2009 Mar;19(3):293-6
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  • Patients with a complex of myxomas, spotty skin pigmentation, and endocrine overactivity, collectively known as Carney complex (CNC), have a predisposition towards the development of thyroid abnormalities, but there are no reports of thymic defects in CNC.
  • Hemithyroidectomy for a Hürthle cell adenoma led to the confirmation of distinct intrathyroidal ectopic thymic tissue.

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  • (PMID = 19265501.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / Z01-HD-000642-04; United States / Intramural NIH HHS / /
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; 0 / PRKAR1A protein, human; 9007-49-2 / DNA
  • [Other-IDs] NLM/ PMC2962859
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100. Ryou KS, Lee SH, Park SH, Park J, Hwang SK, Hamm IS: Multiple fusiform myxomatous cerebral aneurysms in a patient with Carney complex. J Neurosurg; 2008 Aug;109(2):318-20
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  • Carney complex is a rare autosomal-dominant familial tumor syndrome that involves the triad of myxoma, mucocutaneous pigmentation, and endocrine overactivity.
  • The authors report the case of a 38-year-old woman with typical Carney complex who had multiple skin myxomas, endocrine abnormalities, and multiple brownish perioral lesions.
  • [MeSH-minor] Adenoma / complications. Adult. Aneurysm / etiology. Aneurysm / radiography. Cerebral Angiography. Female. Heart Atria. Humans. Pituitary Neoplasms / complications

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  • (PMID = 18671646.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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