[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 534
1. Ong K, Tan KB, Putti TC: Myelolipoma within a non-functional adrenal cortical adenoma. Singapore Med J; 2007 Jul;48(7):e200-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myelolipoma within a non-functional adrenal cortical adenoma.
  • Myelolipoma within an adrenal cortical adenoma is a very rare cause of adrenal incidentaloma, and only nine cases have been reported in the English and Japanese literature.
  • Clinical history, physical examination and laboratory results did not show any evidence to suggest metabolic disorder such as Cushing's syndrome, hyperaldosteronism or catecholamine hypersecretion.
  • The patient underwent a left adrenalectomy, and a histopathological study confirmed the mass to be a non-functional adrenal cortical adenoma containing myelolipoma.
  • To the best of our knowledge, this is the first non-functional adrenal cortical adenoma reported; in the nine cases of myelolipoma within an adrenal cortical adenoma reported previously, all the patients had Cushing's syndrome.
  • The literature on synchronous myelolipoma with adrenal adenoma, and myelolipoma within functional adrenal adenoma, is reviewed.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Myelolipoma / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17609815.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Singapore
  • [Number-of-references] 11
  •  go-up   go-down


2. Lu HS, Gan MF, Chen HS, Huang SQ: Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome. J Zhejiang Univ Sci B; 2008 Jun;9(6):500-5
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for conn's syndrome .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome.
  • The coexistence of myelolipoma within adrenal cortical adenoma is extremely rare, for both tumors present usually as separate entities.
  • To the best of our knowledge, the case we reported here is the first one of myxoid adrenal cortical adenoma associated with myelolipoma reported.
  • Clinical history and laboratory results suggest a metabolic disorder as Conn's syndrome.
  • The patient underwent a left adrenalectomy, and a histopathological study confirmed the mass to be a myxoid adrenal cortical adenoma containing myelolipoma.
  • In the present case report, we also discuss the etiology of simultaneous myelolipoma and adrenal adenoma associated with Conn's syndrome, and the methods of the diagnosis and differential diagnosis.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Hyperaldosteronism / complications. Myelolipoma / complications. Neoplasms, Multiple Primary / complications

  • Genetic Alliance. consumer health - Conn's Syndrome.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Singapore Med J. 2007 Jul;48(7):e200-2 [17609815.001]
  • [Cites] Pediatr Nephrol. 2006 Mar;21(3):433-6 [16382320.001]
  • [Cites] Pathol Int. 2001 Nov;51(11):887-91 [11844057.001]
  • [Cites] Clin Radiol. 2002 Nov;57(11):1034-7 [12409116.001]
  • [Cites] Endocr Res. 2003 Feb;29(1):67-71 [12665319.001]
  • [Cites] Int J Surg Pathol. 2004 Jan;12(1):57-61 [14765276.001]
  • [Cites] Int J Urol. 2004 May;11(5):326-8 [15147550.001]
  • [Cites] Int J Urol. 2004 Jun;11(6):416-8 [15157212.001]
  • [Cites] Pathol Int. 2004 Sep;54(9):725-9 [15363042.001]
  • [Cites] Surgery. 1973 May;73(5):665-70 [4697085.001]
  • [Cites] Pathol Res Pract. 1979 May;164(2):207-13 [223133.001]
  • [Cites] Am J Clin Pathol. 1986 Oct;86(4):541-5 [3766467.001]
  • [Cites] Hinyokika Kiyo. 1992 Jun;38(6):681-4 [1632323.001]
  • [Cites] Panminerva Med. 1992 Oct-Dec;34(4):209-12 [1293551.001]
  • [Cites] Arch Pathol Lab Med. 1994 Nov;118(11):1151-3 [7979904.001]
  • [Cites] J Urol. 1997 Apr;157(4):1213-6 [9120904.001]
  • [Cites] Int J Clin Oncol. 2007 Oct;12(5):379-81 [17929121.001]
  • (PMID = 18543405.001).
  • [ISSN] 1673-1581
  • [Journal-full-title] Journal of Zhejiang University. Science. B
  • [ISO-abbreviation] J Zhejiang Univ Sci B
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Synaptophysin; 0 / Vimentin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins
  • [Number-of-references] 21
  • [Other-IDs] NLM/ PMC2408705
  •  go-up   go-down


3. Shigematsu K, Nishida N, Sakai H, Igawa T, Toriyama K, Nakatani A, Takahara O, Kawai K: Synaptophysin immunoreactivity in adrenocortical adenomas: a correlation between synaptophysin and CYP17A1 expression. Eur J Endocrinol; 2009 Dec;161(6):939-45
MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synaptophysin immunoreactivity in adrenocortical adenomas: a correlation between synaptophysin and CYP17A1 expression.
  • DESIGN AND METHODS: The adrenal cortex is not considered to be an intrinsic part of the diffuse neuroendocrine system, but adrenocortical neoplasms possess neuroendocrine properties.
  • In this study, we examined synaptophysin (SYP) and neural cell adhesion molecule (NCAM) expression in adrenocortical adenomas in relation to adrenal function.
  • RESULTS: Immunohistochemical analysis showed that 50.7 and 98.6% of the cortical adenomas showed SYP and NCAM immunoreactivities respectively.
  • There was no apparent difference in NCAM immunoreactivity among the adenomas.
  • However, the immunostaining for SYP was significantly stronger in cortisol-producing adenomas (CPA) than in aldosterone-producing adenomas (APA), nonfunctioning adenomas (NFA), showing no clinical or endocrinological abnormality, or adenomas associated with preclinical Cushing's syndrome (preCS).
  • CONCLUSIONS: We propose that SYP expression in adrenocortical cells may be involved in some aspect of adrenal function such as transport or secretion of glucocorticoids.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19755404.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neural Cell Adhesion Molecules; 0 / RNA, Messenger; 0 / Synaptophysin; EC 1.14.99.9 / CYP17A1 protein, human; EC 1.14.99.9 / Steroid 17-alpha-Hydroxylase
  •  go-up   go-down


Advertisement
4. Shigematsu K, Nakagaki T, Yamaguchi N, Kawai K, Sakai H, Takahara O: Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas. Eur J Endocrinol; 2008 Jun;158(6):867-78

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas.
  • DESIGN AND METHODS: We have recently demonstrated that the adrenal cortices attached to aldosterone-producing adenoma (APA) contained microscopic subcapsular micronodules suggestive of active aldosterone production.
  • In this study, we used in situ hybridization to investigate the mRNA expression of steroidogenic enzymes in the adrenal cortices attached to cortisol-producing adenoma (CPA) and clinically silent adenoma (non-functioning adenoma; NFA), in addition to APA.
  • Most of the cortical nodules in zona fasciculata to zona reticularis showed a suppressed steroidogenesis in the cortices attached to adenoma, but some expressed intensely all necessary steroidogenic enzyme mRNAs for cortisol synthesis.
  • CONCLUSIONS: It is thus necessary to keep in mind, on the occasion of subtotal adrenalectomy, that lesions with the potential to later develop into functional adrenocortical nodules may be present in other parts of the ipsilateral or contralateral adrenal cortices.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18505908.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / RNA, Messenger; 0 / SPATA7 protein, human; EC 1.14.15.6 / Cholesterol Side-Chain Cleavage Enzyme; EC 1.14.99.9 / CYP17A1 protein, human; EC 1.14.99.9 / Steroid 17-alpha-Hydroxylase; EC 2.8.2.- / Sulfotransferases; EC 2.8.2.2 / alcohol sulfotransferase
  •  go-up   go-down


5. Louiset E, Gobet F, Libé R, Horvath A, Renouf S, Cariou J, Rothenbuhler A, Bertherat J, Clauser E, Grise P, Stratakis CA, Kuhn JM, Lefebvre H: ACTH-independent Cushing's syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma. J Clin Endocrinol Metab; 2010 Jan;95(1):18-24
Hazardous Substances Data Bank. Corticotropin .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] ACTH-independent Cushing's syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma.
  • CONTEXT: Bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma are two rare causes of ACTH-independent Cushing's syndrome.
  • OBJECTIVE: The aim of the study was to evaluate a 35-yr-old woman with ACTH-independent hypercortisolism associated with both micronodular adrenal hyperplasia and ectopic pararenal adrenocortical adenoma.
  • INTERVENTION: Mutations of the PRKAR1A, PDE8B, and PDE11A genes were searched for in leukocytes and adrenocortical tissues.
  • The ability of adrenal and adenoma tissues to synthesize cortisol was investigated by immunohistochemistry, quantitative PCR, and/or cell culture studies.
  • MAIN OUTCOME MEASURE: Detection of 17alpha-hydroxylase and 21-hydroxylase immunoreactivities, quantification of CYP11B1 mRNA in adrenal and adenoma tissues, and measurement of cortisol levels in supernatants by radioimmunological assays were the main outcomes.
  • RESULTS: Histological examination of the adrenals revealed nonpigmented micronodular cortical hyperplasia associated with relative atrophy of internodular cortex.
  • No genomic and/or somatic adrenal mutations of the PRKAR1A, PDE8B, and PDE11A genes were detected.
  • 17alpha-Hydroxylase and 21-hydroxylase immunoreactivities as well as CYP11B1 mRNA were detected in adrenal and adenoma tissues.
  • ACTH and dexamethasone activated cortisol secretion from adenoma cells.
  • CONCLUSION: This case suggests that unknown molecular defects can favor both micronodular adrenal hyperplasia and ectopic adrenocortical adenoma associated with Cushing's syndrome.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenal Glands / pathology. Adrenocortical Adenoma / complications. Choristoma / complications. Cushing Syndrome / complications
  • [MeSH-minor] Adrenocorticotropic Hormone / metabolism. Adrenocorticotropic Hormone / pharmacology. Adult. Drug Resistance / genetics. Drug Resistance / physiology. Female. Humans. Hyperplasia / complications. Hyperplasia / genetics. Hyperplasia / radiography. Kidney Diseases / complications. Kidney Diseases / genetics. Kidney Diseases / radiography

  • Genetic Alliance. consumer health - Cushing's Syndrome.
  • MedlinePlus Health Information. consumer health - Cushing's Syndrome.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Neuroscience. 1992;47(4):999-1007 [1374544.001]
  • [Cites] Eur J Pediatr. 1986 Aug;145(3):236-8 [3769985.001]
  • [Cites] Ann Intern Med. 1999 Oct 19;131(8):585-91 [10523219.001]
  • [Cites] Horm Res. 2005;64(3):119-31 [16215323.001]
  • [Cites] Mol Cell Endocrinol. 2006 Feb 26;246(1-2):142-6 [16388891.001]
  • [Cites] Nat Genet. 2006 Jul;38(7):794-800 [16767104.001]
  • [Cites] J Clin Endocrinol Metab. 2006 Nov;91(11):4205-14 [16912124.001]
  • [Cites] J Clin Endocrinol Metab. 2006 Nov;91(11):4578-86 [16954157.001]
  • [Cites] Nat Clin Pract Endocrinol Metab. 2007 Nov;3(11):748-57 [17955016.001]
  • [Cites] Arq Bras Endocrinol Metabol. 2007 Nov;51(8):1245-52 [18209862.001]
  • [Cites] N Engl J Med. 2008 Feb 14;358(7):750-2 [18272904.001]
  • [Cites] Clin Cancer Res. 2008 Jun 15;14(12):4016-24 [18559625.001]
  • [Cites] Eur J Hum Genet. 2008 Oct;16(10):1245-53 [18431404.001]
  • [Cites] Nat Clin Pract Endocrinol Metab. 2008 Dec;4(12):695-700 [18941436.001]
  • [Cites] J Clin Endocrinol Metab. 2009 Jul;94(7):2406-13 [19383776.001]
  • [Cites] Proc Natl Acad Sci U S A. 1989 Jul;86(13):4978-81 [2544885.001]
  • [Cites] J Clin Endocrinol Metab. 2000 Aug;85(8):2903-6 [10946901.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Sep;86(9):4041-6 [11549623.001]
  • [Cites] Am J Hum Genet. 2002 Dec;71(6):1433-42 [12424709.001]
  • [Cites] J Clin Endocrinol Metab. 2003 May;88(5):1994-8 [12727943.001]
  • [Cites] Cancer Res. 2003 Sep 1;63(17):5308-19 [14500362.001]
  • [Cites] Endocr Relat Cancer. 2004 Jun;11(2):265-80 [15163302.001]
  • [Cites] J Clin Endocrinol Metab. 1966 Mar;26(3):299-304 [4286018.001]
  • [Cites] Horm Metab Res. 1969 May;1(3):149-50 [4258876.001]
  • [Cites] Am J Med. 1981 May;70(5):1122-5 [7234878.001]
  • [Cites] J Clin Endocrinol Metab. 1985 Jan;60(1):21-8 [3964792.001]
  • [Cites] J Clin Endocrinol Metab. 1998 Nov;83(11):3786-9 [9814447.001]
  • (PMID = 19915020.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone
  • [Other-IDs] NLM/ PMC2805485
  •  go-up   go-down


6. Park SH, Kim MJ, Kim JH, Lim JS, Kim KW: Differentiation of adrenal adenoma and nonadenoma in unenhanced CT: new optimal threshold value and the usefulness of size criteria for differentiation. Korean J Radiol; 2007 Jul-Aug;8(4):328-35
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differentiation of adrenal adenoma and nonadenoma in unenhanced CT: new optimal threshold value and the usefulness of size criteria for differentiation.
  • OBJECTIVE: To determine the optimal threshold for the attenuation values in unenhanced computed tomography (CT) and assess the value of the size criteria for differentiating between an adrenal adenoma and a nonadenoma.
  • MATERIALS AND METHODS: The unenhanced CT images of 45 patients at our institution, who underwent a surgical resection of an adrenal masses between January 2001 and July 2005, were retrospectively reviewed.
  • Forty-five adrenal masses included 25 cortical adenomas, 12 pheochromocytomas, three lymphomas, and five metastases confirmed by pathology were examined.
  • The mean attenuation values of an adrenal adenoma and nonadenoma were compared using an unpaired t test.
  • RESULTS: The twenty-five adenomas showed significantly lower (p < 0.05) attenuation values (mean+/-SD; 16.3+/-14.9) than the nonadenomas (38.1+/-6.8).
  • The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for diagnosing adenomas were 36%, 100%, 100%, 56%, and 64%, respectively, at a threshold of 10 HU; 60%, 100%, 100%, 67%, and 78%, respectively, at a threshold of 20 HU; and 72%, 95%, 95%, 73%, and 82%, respectively, at a threshold of 25 HU.
  • The adenomas had a significantly (p < 0.05) smaller diameter (2.44+/-1.24 cm) than the nonadenomas (5.09+/-2.37 cm).
  • CONCLUSION: The threshold attenuation values of 20 or 25 HU in the unenhanced CT appear optimal for discriminating an adrenal adenoma from a nonadenoma.
  • The size criteria are of little value in differentiating adrenal masses because of their low specificity or low sensitivity.
  • [MeSH-major] Adenoma / radiography. Adrenal Gland Neoplasms / radiography

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Urology. 1975 May;5(5):691-5 [1129901.001]
  • [Cites] J Pathol. 1969 Sep;99(1):1-18 [5359219.001]
  • [Cites] AJR Am J Roentgenol. 1982 Jul;139(1):81-5 [6979870.001]
  • [Cites] Ann Intern Med. 1983 Jun;98(6):940-5 [6344711.001]
  • [Cites] Radiology. 1983 Aug;148(2):495-9 [6867348.001]
  • [Cites] Radiology. 1984 Oct;153(1):217-8 [6473783.001]
  • [Cites] AJR Am J Roentgenol. 1985 Jan;144(1):61-5 [3871149.001]
  • [Cites] AJR Am J Roentgenol. 1985 Jan;144(1):67-9 [3871150.001]
  • [Cites] Am J Surg. 1985 Jun;149(6):783-8 [4014556.001]
  • [Cites] Magn Reson Imaging. 1987;5(5):339-44 [3695820.001]
  • [Cites] Acta Radiol. 1988 Sep-Oct;29(5):519-22 [3166873.001]
  • [Cites] AJR Am J Roentgenol. 1989 May;152(5):1005-7 [2705336.001]
  • [Cites] AJR Am J Roentgenol. 1989 Oct;153(4):771-3 [2773732.001]
  • [Cites] Radiology. 1991 May;179(2):415-8 [2014283.001]
  • [Cites] Surgery. 1991 Dec;110(6):1014-21 [1745970.001]
  • [Cites] Arch Surg. 1994 Mar;129(3):291-6 [8129606.001]
  • [Cites] J Comput Assist Tomogr. 1994 May-Jun;18(3):432-8 [8188912.001]
  • [Cites] Cleve Clin J Med. 1994 May-Jun;61(3):200-5 [8026063.001]
  • [Cites] Radiology. 1994 Nov;193(2):341-4 [7972740.001]
  • [Cites] Endocr Rev. 1995 Aug;16(4):460-84 [8521790.001]
  • [Cites] AJR Am J Roentgenol. 1995 Dec;165(6):1453-9 [7484585.001]
  • [Cites] Abdom Imaging. 1995 Nov-Dec;20(6):559-62 [8580753.001]
  • [Cites] AJR Am J Roentgenol. 1996 Mar;166(3):531-6 [8623622.001]
  • [Cites] Radiology. 1996 Sep;200(3):743-7 [8756925.001]
  • [Cites] Radiol Clin North Am. 1996 Sep;34(5):1037-54 [8784395.001]
  • [Cites] AJR Am J Roentgenol. 1998 Mar;170(3):747-52 [9490968.001]
  • [Cites] Radiology. 1998 May;207(2):369-75 [9577483.001]
  • [Cites] AJR Am J Roentgenol. 1998 Jul;171(1):201-4 [9648789.001]
  • [Cites] J Clin Endocrinol Metab. 2005 Feb;90(2):871-7 [15572420.001]
  • [Cites] Radiographics. 2001 Jul-Aug;21(4):995-1012 [11452074.001]
  • [Cites] Surgery. 2001 Dec;130(6):1068-71 [11742340.001]
  • [Cites] Curr Opin Oncol. 2002 Jan;14(1):58-63 [11790982.001]
  • [Cites] Radiology. 2002 Mar;222(3):629-33 [11867777.001]
  • [Cites] Ann Intern Med. 2003 Mar 4;138(5):424-9 [12614096.001]
  • [Cites] Lancet. 1967 Mar 4;1(7488):468-70 [4164067.001]
  • [Cites] AJR Am J Roentgenol. 1982 Jun;138(6):1143-8 [6979217.001]
  • (PMID = 17673844.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627166
  •  go-up   go-down


7. Ouzounian S, Tissier F, Gouya H, Kujas M, Louvel A, Legmann P, Bertagna X: [Cushing's syndrome and adrenal adenoma. Two surprising associations]. Presse Med; 2005 Apr 09;34(7):511-5
MedlinePlus Health Information. consumer health - Cushing's Syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cushing's syndrome and adrenal adenoma. Two surprising associations].
  • [Transliterated title] Maladie de Cushing et adénome cortico-surrénalien. Deux associations étonnantes.
  • CASES: In the first case, we describe the case of a patient with an adrenal adenoma 20 years before the occurrence of Cushing's disease related to the pineal gland.
  • In the second case, two members of the same family were diagnosed almost simultaneously with adrenal cortical adenoma (mother) and Cushing's disease (daughter).
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Cushing Syndrome / etiology

  • Genetic Alliance. consumer health - Cushing's Syndrome.
  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15903005.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  •  go-up   go-down


8. Mete O, Asa SL: Aldosterone-producing adrenal cortical adenoma with oncocytic change and cytoplasmic eosinophilic globular inclusions. Endocr Pathol; 2009;20(3):182-5
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aldosterone-producing adrenal cortical adenoma with oncocytic change and cytoplasmic eosinophilic globular inclusions.
  • We report an interesting morphological alteration in the adrenal of a 72-year-old woman suffering from severe hypertension due to primary hyperaldosteronism.
  • The laparoscopic left adrenalectomy specimen revealed an adrenal cortical adenoma composed of varying proportions of oncocytic and clear cells, predominantly showing central oncocytic change.
  • Oncocytes also exhibited numerous eosinophilic intracytoplasmic globular inclusions, which are not commonly observed in aldosterone-producing adrenal cortical adenomas.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Aldosterone / secretion. Inclusion Bodies / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19462261.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 4964P6T9RB / Aldosterone
  •  go-up   go-down


9. Sherer DM, Dalloul M, Wagreich A, Sokolovski M, Duan H, Zinn H, Abulafia O: Prenatal sonographic findings of congenital adrenal cortical adenoma. J Ultrasound Med; 2008 Jul;27(7):1091-3
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prenatal sonographic findings of congenital adrenal cortical adenoma.
  • The differential diagnosis of prenatally diagnosed adrenal masses includes neuroblastoma, adrenal hemorrhage, adrenal and cortical renal cysts, adrenal adenoma and carcinoma, subdiaphragmatic pulmonary sequestration, Beckwith-Wiedemann syndrome, duplication of the renal system, Wilms tumors, congenital mesoblastic nephroma, and mesenteric and enteric duplication cysts.
  • The worldwide annual incidence of childhood adrenal cortical neoplasms ranges between 0.3 and 0.38 per 1 million children younger than 15 years.
  • [MeSH-major] Adrenal Cortex Neoplasms / congenital. Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / congenital. Adrenocortical Adenoma / diagnosis. Ultrasonography, Prenatal / methods
  • [MeSH-minor] Adrenal Cortex / surgery. Adrenal Cortex / ultrasonography. Adult. Diagnosis, Differential. Female. Humans. Imaging, Three-Dimensional / methods. Infant, Newborn. Male. Pregnancy. Radiography, Abdominal / methods. Tomography, X-Ray Computed

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18577675.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


10. Makino K, Kojima R, Nakamura H, Morioka M, Iyama K, Shigematsu K, Kuratsu J: Ectopic adrenal cortical adenoma in the spinal region: case report and review of the literature. Brain Tumor Pathol; 2010 Oct;27(2):121-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic adrenal cortical adenoma in the spinal region: case report and review of the literature.
  • Ectopic adrenal cortical neoplasms are extremely rare; few involve the central nervous system (CNS).
  • We report a 17-month-old girl with spinal adrenal cortical neoplasms.
  • In addition, the nuclei stained positive for steroidogenic factor 1 (Ad4BP/SF-1), which is involved in adrenal steroidogenesis.
  • This case confirms the occurrence of adrenocortical adenoma in the CNS.
  • We suggest that this tumor should be considered in the differential diagnosis of CNS tumors.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adrenal Cortex Diseases. Choristoma. Dura Mater / pathology. Female. Humans. Immunohistochemistry. Infant. Inhibins / metabolism. Magnetic Resonance Imaging. Spinal Cord. Steroidogenic Factor 1 / metabolism. Tissue Fixation

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21046315.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Steroidogenic Factor 1; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins
  •  go-up   go-down


11. Karikari IO, Uschold TD, Selznick LA, Carter JH, Cummings TJ, Friedman AH: Primary spinal intramedullary adrenal cortical adenoma associated with spinal dysraphism: case report. Neurosurgery; 2006 Nov;59(5):E1144; discussion E1144
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spinal intramedullary adrenal cortical adenoma associated with spinal dysraphism: case report.
  • OBJECTIVE: The authors report a primary spinal intramedullary adrenal cortical adenoma in a patient with spinal dysraphism presenting with bilateral leg pain and urinary frequency.
  • METHODS: Magnetic resonance imaging, L2 laminectomy with resection of mass, and pathological and immunohistochemical analysis of resected mass revealed the diagnosis.
  • RESULTS: Microscopic and immunohistochemical findings confirmed the diagnosis as a primary intramedullary tumor of adrenal cortical origin.
  • CONCLUSION: The occurrence of a primary adrenal tumor in the spinal cord is rare and difficult to explain based on our understanding of embryology.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenal Cortex Neoplasms / surgery. Adrenocortical Adenoma / diagnosis. Adrenocortical Adenoma / surgery. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery. Spinal Dysraphism / complications

  • MedlinePlus Health Information. consumer health - Spina Bifida.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17143207.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


12. Wu Z, Ni D, Yan Y, Li J, Wang B, Ouyang J, Zhang G, Ma X, Li H, Zhang X: Expression of angiotensin II receptors in aldosterone-producing adenoma of the adrenal gland and their clinical significance. J Huazhong Univ Sci Technolog Med Sci; 2010 Aug;30(4):486-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of angiotensin II receptors in aldosterone-producing adenoma of the adrenal gland and their clinical significance.
  • The expression of angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R) in aldosterone-producing adenoma (APA) of the adrenal gland was detected, and their relationship with clinical indexes of APA was analyzed.
  • The mRNA expression of AT1R and AT2R in 50 cases of APA and tissues adjacent to tumors and 12 cases of normal adrenal tissues was detected by using reverse transcriptase polymerase chain reaction (RT-PCR).
  • The expression of AT1R in adenoma, tissues adjacent to tumor, and normal tissues of the adrenal gland showed no significant differences.
  • The expression of AT2R in APA tissue was lower than that in normal adrenal gland tissues (P<0.05).
  • [MeSH-major] Adenoma / metabolism. Adrenal Gland Neoplasms / metabolism. Aldosterone / blood. Receptor, Angiotensin, Type 1 / metabolism. Receptor, Angiotensin, Type 2 / metabolism

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20714875.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / AGTR1 protein, human; 0 / RNA, Messenger; 0 / Receptor, Angiotensin, Type 1; 0 / Receptor, Angiotensin, Type 2; 4964P6T9RB / Aldosterone
  •  go-up   go-down


13. Ziaja J, Cholewa K, Mazurek U, Cierpka L: [Molecular basics of aldosterone and cortisol synthesis in normal adrenals and adrenocortical adenomas]. Endokrynol Pol; 2008 Jul-Aug;59(4):330-9
Hazardous Substances Data Bank. HYDROCORTISONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Molecular basics of aldosterone and cortisol synthesis in normal adrenals and adrenocortical adenomas].
  • [Transliterated title] Molekularne podstawy syntezy aldosteronu i kortyzolu w prawidlowych nadnerczach i w gruczolakach kory nadnerczy.
  • The aim of the study is to present genes encoding enzymatic proteins of aldosterone and cortisol synthesis pathway, methods of their transcriptional activity measurement, mRNA expression of the genes in normal adrenal cortex, in adrenocortical adenomas excised from patients with Conn and Cushing syndromes, as well as in adrenocortical adenomas excised from patients, in which hormonal activity of the tumour was not confirmed.
  • According to presented papers mRNA expression of analyzed genes is best known in tissue obtained from tumours excised from patients with Conn syndrome.
  • On the other hand transcriptional activity of the genes within the other adrenocortical adenomas is documented in lesser degree.
  • It concerns particularly analyses of tissue material obtained from patients, in which hormonal activity of adrenal tumours was not confirmed with biochemical tests.
  • It should be also considered, that the frame of reference for the majority of molecular analyses of adrenocortical tumour tissues was material obtained from little number of normal adrenals, what decreases in some degree credibility of obtained results.
  • Mentioned above remarks may be the basis for conduction of further investigations based on larger material, obtained both from normal adrenals and adrenocortical adenomas.
  • [MeSH-major] Adrenal Cortex Neoplasms / enzymology. Adrenal Glands / metabolism. Adrenocortical Adenoma / enzymology. Aldosterone / biosynthesis. Gene Expression Regulation, Enzymologic. Hydrocortisone / biosynthesis. Mixed Function Oxygenases / genetics
  • [MeSH-minor] Adrenal Cortex / metabolism. Cushing Syndrome / genetics. Cushing Syndrome / metabolism. Cytochrome P-450 CYP11B2 / genetics. Humans. Hyperaldosteronism / genetics. Hyperaldosteronism / metabolism. RNA, Messenger / analysis. Reference Values. Transcription, Genetic

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18777504.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / RNA, Messenger; 4964P6T9RB / Aldosterone; EC 1.- / Mixed Function Oxygenases; EC 1.14.15.4 / Cytochrome P-450 CYP11B2; WI4X0X7BPJ / Hydrocortisone
  • [Number-of-references] 76
  •  go-up   go-down


14. Mac Gregor Gooch AL, Guillermina Velasco Diaz G, Carranza Lira S: [Virilizing adrenal adenoma: a report of a case]. Ginecol Obstet Mex; 2005 May;73(5):261-4
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Virilizing adrenal adenoma: a report of a case].
  • [Transliterated title] Adenoma suprarrenal virilizante: comunicación de un caso.
  • Androgen excess can be due to different entities such as polycystic ovarian syndrome, ovarian tumors or adrenal tumors.
  • It is presented the case of a 26 year-old woman that suffered from amenorrhea, hirsutism, voice deepening, reduction of mammary volume and 10 kg weight loss, without response to different treatments.
  • The CAT scan and nuclear magnetic imaging of adrenal glands showed an oval retroperitoneal image of 7.2 x 6.5 x 8.4 cm at the right adrenal gland.
  • Surgery was performed and the right adrenal gland excised.
  • The histopathologic report indicated a benign cortical adenoma.
  • [MeSH-major] Adenoma / complications. Adrenal Cortex Neoplasms / complications. Virilism / etiology

  • Hazardous Substances Data Bank. ANDROSTENEDIONE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21966765.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 409J2J96VR / Androstenedione; 57B09Q7FJR / Dehydroepiandrosterone Sulfate
  •  go-up   go-down


15. Yip L, Tublin ME, Falcone JA, Nordman CR, Stang MT, Ogilvie JB, Carty SE, Yim JH: The adrenal mass: correlation of histopathology with imaging. Ann Surg Oncol; 2010 Mar;17(3):846-52
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The adrenal mass: correlation of histopathology with imaging.
  • BACKGROUND: Computed tomography (CT) and magnetic resonance (MR) imaging can help diagnose benign adrenal adenomas, but prior studies rely on nonoperative follow-up as proof of a lesion's benign nature.
  • Imaging results were considered to signify benign adrenal adenoma if one or more of the following was present: Hounsfield units <10 on unenhanced CT, contrast-enhanced CT quantifying absolute contrast washout of >60% or relative contrast washout of >40%, or MR with chemical-shift imaging demonstrating loss of signal intensity on out-of-phase images.
  • RESULTS: The sensitivity and specificity of preoperative imaging in predicting benign adrenal adenoma were 57 and 94%, respectively.
  • Histopathology confirmed that all 66 adrenal masses with imaging characteristics suggesting benign adenoma were indeed benign lesions and included 61 benign adrenal adenomas and 5 benign nonadenomatous lesions (3 myelolipomas, 1 composite myelolipoma/adenoma, and 1 ganglioliponeuroma).
  • Malignant adrenal lesions were diagnosed in 17/130 (13%) masses: 8 metastases, 7 adrenal cortical carcinomas, 1 epithelioid angiosarcoma, and 1 ganglioneuroblastoma.
  • CONCLUSION: CT or MR characteristics predicted the presence of benign lesions with 100% specificity.
  • Every adrenal malignancy had CT or MR results that were inconsistent with benign adenoma (100% sensitivity).
  • To exclude malignancy, adrenal masses with non-benign imaging characteristics should be resected.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radiography. Adrenocortical Adenoma / pathology. Adrenocortical Adenoma / radiography. Magnetic Resonance Imaging. Tomography, X-Ray Computed

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • MedlinePlus Health Information. consumer health - CT Scans.
  • MedlinePlus Health Information. consumer health - MRI Scans.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19960266.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


16. Babinska A, Sworczak K, Wisniewski P, Nałecz A, Jaskiewicz K: The role of immunohistochemistry in histopathological diagnostics of clinically "silent" incidentally detected adrenal masses. Exp Clin Endocrinol Diabetes; 2008 Apr;116(4):246-51
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of immunohistochemistry in histopathological diagnostics of clinically "silent" incidentally detected adrenal masses.
  • BACKGROUND: The detectability of adrenal incidentalomas (incidentally found adrenal tumours) in the whole population is estimated at 0.1%; 0.42% in non-endocrine patients and at 4.3% in oncologically diagnosed ones.
  • Even up to 16% of incidentalomas of adrenal glands can be malignant lesions.
  • The issue of crucial importance is the histopathological differentiation between benign lesions and malignant tumours of the adrenal cortex and medulla.
  • OBJECTIVES: To evaluate whether the immunohistochemical analysis of the expression of p53, p21, PCNA and Ki67 in the tumour's tissue can be useful in the histopathological diagnostics of adrenal incidentalomas and whether it is important for prognosis.
  • There were 43 cortical adenomas, 11 cortical adrenocarcinomas and 20 PHEOs (including 5 malignant lesions).
  • RESULTS: We found a statistically significant correlation between the expression of p53, p21, Ki67 and the differential diagnosis of adrenal cortical adenoma and adrenocortical carcinoma (for proteins: p53 p=0.010, for p21 p=0.010, for Ki67 p<0.001).
  • The statistical significant correlation between PCNA protein and diagnosis of adrenal cortical adenoma and adrenocortical carcinoma was not found.
  • The statistically significant correlation between p21, PCNA proteins and the diagnosis of benign and malignant PHEOs was not estimated.
  • There was no expression of Ki67 or p53 protein above the assumed level in benign and malignant pheochromocytomas.
  • [MeSH-major] Adenoma / pathology. Adrenal Gland Neoplasms / pathology. Pheochromocytoma / pathology
  • [MeSH-minor] Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Ki-67 Antigen / genetics. Proliferating Cell Nuclear Antigen / genetics. Proto-Oncogene Proteins c-bcl-2 / genetics. Tumor Suppressor Protein p53 / genetics. p21-Activated Kinases / genetics

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • MedlinePlus Health Information. consumer health - Pheochromocytoma.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18393131.001).
  • [ISSN] 0947-7349
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; EC 2.7.11.1 / p21-Activated Kinases
  •  go-up   go-down


17. Tian L, Guo Y, Wu YP, Liu LZ: [CT features of adrenal cortical adenoma: a report of 109 cases]. Ai Zheng; 2008 Jan;27(1):66-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [CT features of adrenal cortical adenoma: a report of 109 cases].
  • BACKGROUND & OBJECTIVE: Adrenal cortical adenoma (ACA) is a common disease, and can be diagnosed easily with CT examination.
  • However, some atypical adenomas are likely to be misdiagnosed.
  • RESULTS: Of the 109 cases of ACA, 104 showed unilateral single adenoma, 1 showed unilateral 2 adenomas, and 4 showed bilateral adenomas.
  • The maximal diameter of non-functional adenomas was larger than that of Cushing's adenomas, and the latter was larger than that of Conn's adenomas.
  • The probability of degeneration was higher in large adenomas than in small adenomas.
  • [MeSH-major] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Radiographic Image Enhancement / methods. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Tumor Burden. Young Adult

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18184467.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  •  go-up   go-down


18. De Padua M, Rajagopal V: Myxoid adrenal adenoma with focal pseudoglandular pattern. Indian J Med Sci; 2008 May;62(5):199-203

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myxoid adrenal adenoma with focal pseudoglandular pattern.
  • Adrenal cortical tumors with myxoid change are rare tumors.
  • To our knowledge, only 22 cases have been described so far in literature, which include 13 carcinomas and 9 adenomas.
  • We report a case of a myxoid adenoma of the left adrenal gland in a 67-year-old woman, with a focal pseudoglandular pattern involving about 20% of the studied tumor.
  • Immunophenotype was consistent with an adrenal tumor, i.e., positive for vimentin, inhibin, and melan A.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18579979.001).
  • [ISSN] 0019-5359
  • [Journal-full-title] Indian journal of medical sciences
  • [ISO-abbreviation] Indian J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  •  go-up   go-down


19. Schittenhelm J, Ebner FH, Harter P, Bornemann A: Symptomatic intraspinal oncocytic adrenocortical adenoma. Endocr Pathol; 2009;20(1):73-7
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Symptomatic intraspinal oncocytic adrenocortical adenoma.
  • Benign epithelial tumors are rarely found at this site.
  • We here present the case of a 44-year-old woman with a lesion in the cauda equina that fulfilled the radiologic criteria of schwannoma and caused clinical symptoms for 3 years.
  • This immunoprofile indicated adrenocortical origin.
  • The diagnosis of an oncocytic adrenal cortical adenoma was made.
  • These extraadrenal tumors are thought to arise from heterotopic adrenocortical tissue in the spinal cavity.
  • Oncocytic tumors are rare neoplasms and they comprise non-functioning variants of adrenal cortical adenomas.
  • Immunohistochemistry excluded oncocytic paraganglioma, oncocytic meningioma, renal cell carcinoma, alveolar soft part sarcoma, and granular cell tumor.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenocortical Adenoma / pathology. Spinal Cord Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19039533.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


20. Nomikos IN, Zizi-Serbetzoglou A, Matsakis G, Elemenoglou J, Vamvakopoulos NC: Association of an oversized adrenal cortical adenoma with expression of pheochromocytoma-like neurosecretory features. J BUON; 2008 Jul-Sep;13(3):425-8
MedlinePlus Health Information. consumer health - Pheochromocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of an oversized adrenal cortical adenoma with expression of pheochromocytoma-like neurosecretory features.
  • Abnormal stimulation of adrenal function may be either direct, affecting similarly cortical and medullary secretion, or indirect affecting primarily the medulla.
  • Indirect activation of clinically detectable adrenomedullary function may develop as a physical consequence of a non-functional adrenal tumor exerting pressure on the medulla by its size, location and direction of growth.
  • Our case of an oversized and overweight adrenal tumor associated with expression of late-onset pheochromocytoma-like clinical symptoms may be explained by the physical indirect rather than the biological direct activation of adrenomedullary function like hyperplasia or cancer.
  • [MeSH-major] Adenoma / pathology. Adrenal Cortex Neoplasms / pathology. Adrenal Medulla / pathology. Pheochromocytoma / pathology

  • Genetic Alliance. consumer health - Pheochromocytoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18979561.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 57285-09-3 / Inhibins
  •  go-up   go-down


21. Chen KT: Extraneous cells of hepatic origin in adrenal fine needle aspiration as a diagnostic pitfall: a case report. Acta Cytol; 2005 Jul-Aug;49(4):449-51
MedlinePlus Health Information. consumer health - Tumors and Pregnancy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extraneous cells of hepatic origin in adrenal fine needle aspiration as a diagnostic pitfall: a case report.
  • BACKGROUND: The fine needle aspiration (FNA) cytologic evaluations of most adrenal lesions are straightforward.
  • After delivery, computed tomography-guided FNA showed bland epithelial cells, and a diagnosis of adrenal cortical adenoma was made.
  • However, subsequent resection showed a myelolipoma of the adrenal gland.
  • CONCLUSION: This case illustrated 2 cytodiagnostic pitfalls in adrenal fine needle aspirates.
  • First, the myeloid cells characteristic of a myelolipoma were not present in the FNA smears because a large portion of the lesion was composed of fibroadipose tissue.
  • Second, extraneous, benign cells of hepatic origin were misinterpreted as adrenal cortical adenoma cells.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Hepatocytes / pathology. Myelolipoma / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adrenal Cortex Neoplasms / diagnosis. Adrenal Glands / pathology. Adrenocortical Adenoma / diagnosis. Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Pregnancy. Tomography, X-Ray Computed

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16124179.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


22. Hennings J, Sundin A, Hägg A, Hellman P: 11C-metomidate positron emission tomography after dexamethasone suppression for detection of small adrenocortical adenomas in primary aldosteronism. Langenbecks Arch Surg; 2010 Sep;395(7):963-7
Hazardous Substances Data Bank. DEXAMETHASONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 11C-metomidate positron emission tomography after dexamethasone suppression for detection of small adrenocortical adenomas in primary aldosteronism.
  • PURPOSE: To evaluate whether dexamethasone suppression treatment can improve (11) C-metomidate positron emission tomography (MTO-PET) detection of small adrenocortical adenomas in primary aldosteronism (PA).
  • MATERIALS AND METHODS: Eleven patients with proven PA and two patients with non-hyperfunctioning adrenocortical incidentalomas and small adrenocortical tumours observed on CT underwent MTO-PET before and 3 days after administration of oral dexamethasone suppression treatment.
  • RESULTS: All tumours were detected and categorised as adrenocortical by MTO-PET.
  • SUVhs as well as SUVmax were higher in PA compared to nonfunctional adenomas.
  • Normal adrenal cortex was suppressed after dexamethasone (p < 0.05), but tumour SUV was not significantly decreased after suppression in either PA or nonfunctional tumours (p > 0.05).
  • However, these changes caused no significant increase in the tumour-to-normal adrenal ratio (p > 0.05).
  • CONCLUSION: MTO-PET is a highly sensitive method for detecting and categorising even small adrenocortical tumours in PA.
  • In this series, dexamethasone-suppressed MTO-PET was unable to increase the tumour-to-normal adrenal ratio to further facilitate detection of small adenomas in PA as an alternative to adrenal venous sampling.
  • [MeSH-major] Adrenocortical Adenoma / diagnostic imaging. Adrenocortical Adenoma / drug therapy. Dexamethasone / therapeutic use. Hyperaldosteronism / diagnostic imaging. Hyperaldosteronism / drug therapy. Positron-Emission Tomography / methods

  • Genetic Alliance. consumer health - Primary aldosteronism.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Med. 1984 Nov;77(5):839-44 [6496538.001]
  • [Cites] Am Surg. 2007 Feb;73(2):174-80 [17305298.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Mar;89(3):1045-50 [15001583.001]
  • [Cites] Eur J Nucl Med Mol Imaging. 2004 Sep;31(9):1224-30 [15197504.001]
  • [Cites] J Hypertens. 2003 Nov;21(11):2149-57 [14597859.001]
  • [Cites] Langenbecks Arch Surg. 2007 Sep;392(5):623-8 [17242897.001]
  • [Cites] Surgery. 2008 Dec;144(6):926-33; discussion 933 [19040999.001]
  • [Cites] ANZ J Surg. 2007 Sep;77(9):768-73 [17685956.001]
  • [Cites] Arch Intern Med. 2008 Jan 14;168(1):80-5 [18195199.001]
  • [Cites] J Clin Endocrinol Metab. 2006 Apr;91(4):1410-4 [16403816.001]
  • [Cites] Scand J Surg. 2008;97(3):248-53 [18812275.001]
  • [Cites] World J Surg. 2008 May;32(5):847-53 [18343972.001]
  • [Cites] Eur J Radiol. 2009 Feb;69(2):314-23 [18082990.001]
  • [Cites] Semin Nucl Med. 1989 Apr;19(2):122-43 [2652311.001]
  • [Cites] J Clin Endocrinol Metab. 2008 Sep;93(9):3266-81 [18552288.001]
  • [Cites] Nat Clin Pract Nephrol. 2006 Apr;2(4):198-208; quiz, 1 p following 230 [16932426.001]
  • [Cites] Eur J Endocrinol. 2004 Jul;151(1):73-85 [15248825.001]
  • [Cites] J Hypertens. 2008 Sep;26(9):1816-23 [18698217.001]
  • [Cites] J Nucl Med. 2004 Jun;45(6):972-9 [15181132.001]
  • [Cites] Eur J Nucl Med. 1999 Oct;26(10 ):1326-32 [10541832.001]
  • [Cites] J Nucl Med. 2000 Feb;41(2):275-82 [10688111.001]
  • [Cites] J Vasc Interv Radiol. 2008 Jan;19(1):66-71 [18192469.001]
  • (PMID = 20644954.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 5377-20-8 / metomidate; 7S5I7G3JQL / Dexamethasone; Z22628B598 / Etomidate
  •  go-up   go-down


23. Hwang WR, Ma WY, Tso AL, Pan CC, Chang YH, Lin HD: Pheochromocytoma and adrenocortical adenoma in the same gland. J Chin Med Assoc; 2007 Jul;70(7):289-93
Hazardous Substances Data Bank. Corticotropin .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pheochromocytoma and adrenocortical adenoma in the same gland.
  • A right adrenal tumor was found incidentally during abdominal computed tomography exam in a 51-year-old female patient, who had had diabetes and hypertension for more than 10 years.
  • Therefore, adrenal cortical adenoma with subclinical Cushing's syndrome was highly suspected; however, further imaging studies, including magnetic resonance image and 131I-6beta-iodomethylnorcholesterol adrenal scintigraphy failed to discriminate an additional tumor.
  • After right adrenalectomy, a small adrenal cortical adenoma and a large pheochromocytoma were noted.
  • This is an extremely rare case of an adrenal incidentaloma consisting of both medullary and cortical tumors in the same gland.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenal Gland Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pheochromocytoma / diagnosis

  • Genetic Alliance. consumer health - Pheochromocytoma.
  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • MedlinePlus Health Information. consumer health - Pheochromocytoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17631466.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone
  •  go-up   go-down


24. Hirose A, Okada Y, Fukushima A, Tanaka Y: [A rare case of primary aldosteronism caused by bilateral functioning adrenocortical adenomas with renal cell carcinoma]. J UOEH; 2005 Dec 1;27(4):315-23
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A rare case of primary aldosteronism caused by bilateral functioning adrenocortical adenomas with renal cell carcinoma].
  • We report a rare case of bilateral primary aldosteronism with renal cell carcinoma.
  • Abdominal CT and MRI revealed tumor masses in both adrenal glands, and a large left renal mass.
  • The preoperative diagnosis was primary aldosteronism due to bilateral functioning adrenocortical adenomas and left renal cell carcinoma.
  • The Pathological diagnosis was left renal cell carcinoma and bilateral functioning adrenocortical adenomas.
  • Primary aldosteronism due to bilateral functioning adrenocortical adenomas is relatively rare and its complication with renal cell carcinoma is an extremely rare case.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Carcinoma, Renal Cell / complications. Hyperaldosteronism / etiology. Kidney Neoplasms / complications


25. Solís-López DR, Rodríguez-Hernández Z, Solís-López DH: Incidental adreno-cortical adenoma, why surgery? a case report. P R Health Sci J; 2010 Jun;29(2):130-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidental adreno-cortical adenoma, why surgery? a case report.
  • INTRODUCTION: Incidental adrenal tumors are commonly benign, but reports demonstrate that if the characteristics of the tumor are not clear, on images surgery is the procedure of choice.
  • Our objective through this case is to show that laparoscopic adrenalectomy is a safe approach for adrenal incidental tumor regardless of radiological findings.
  • She went for check up and a left adrenal mass on MRI described as myelolipoma was found incidentally.
  • The pathological report was adrenal cortical adenoma with central hemorrhage and not a myelolipoma as described in images on magnetic resonance imaging (MRI).
  • CONCLUSION: The use of imaging for diagnosis, clinical management and decision making is very controversial.
  • Laparoscopic surgery for adrenal masses is a safe procedure for tumors of 6 cm regardless of the radiological description.
  • [MeSH-major] Adrenal Cortex Neoplasms / surgery. Adrenocortical Adenoma / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20496530.001).
  • [ISSN] 0738-0658
  • [Journal-full-title] Puerto Rico health sciences journal
  • [ISO-abbreviation] P R Health Sci J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Puerto Rico
  •  go-up   go-down


26. Farkas A, Horányi J, Gláz E, Kulka J: [Oncocytic tumor of the adrenal gland]. Orv Hetil; 2005 Jul 3;146(27):1453-8
MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Oncocytic tumor of the adrenal gland].
  • [Transliterated title] Oncocytás mellékvese-adenoma.
  • Oncocytic tumor of the adrenal gland.
  • The authors describe a case of a rare tumor arising in the adrenal gland.
  • The tumor 6 cm in diameter, connected to the right adrenal gland, was found incidentally in a healthy young man of 34 years of age, who suffered an accident and had a rib fracture.
  • The right adrenal gland with the tumor was removed by laparoscopic surgery.
  • Histopathological examination revealed an oncocytic adenoma of the adrenal cortex.
  • The authors describe the morphology and the differential diagnosis of this rare tumor of the adrenal gland.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adrenal Gland Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Incidental Findings. Male

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16089107.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Number-of-references] 12
  •  go-up   go-down


27. Park BK, Kim CK, Jung BC, Suh YL: Cortical adenoma in adrenohepatic fusion tissue: clue to making a correct diagnosis at preoperative computed tomography examination. Eur Urol; 2009 Dec;56(6):1082-5
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cortical adenoma in adrenohepatic fusion tissue: clue to making a correct diagnosis at preoperative computed tomography examination.
  • Preoperative differential diagnoses included primary or secondary malignant hepatic tumors or adrenal cortical carcinoma due to aggressive imaging features.
  • The tumor proved to be an adrenal cortical adenoma arising from the adrenohepatic fusion tissue and consisted of adenoma cells with lipid-rich cytoplasm.
  • Retrospective review of preoperative computed tomography (CT) images demonstrated that the tumor measured 6 Hounsfield units in mean CT number and was continuous with a medial limb of the right adrenal gland.
  • [MeSH-major] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Liver Neoplasms / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Preoperative Care. Ultrasonography

  • MedlinePlus Health Information. consumer health - CT Scans.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19447543.001).
  • [ISSN] 1873-7560
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


28. Takehara K, Sakai H, Shono T, Irie J, Kanetake H: Proliferative activity and genetic changes in adrenal cortical tumors examined by flow cytometry, fluorescence in situ hybridization and immunohistochemistry. Int J Urol; 2005 Feb;12(2):121-7
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Proliferative activity and genetic changes in adrenal cortical tumors examined by flow cytometry, fluorescence in situ hybridization and immunohistochemistry.
  • BACKGROUND: To determine differences in biological features among different adrenal tumors, we investigated the DNA ploidy, numerical chromosomal aberration and proliferative activity in human adrenal cortical neoplasms.
  • METHODS: Our study included six adrenal cortical adenomas with Cushing syndrome, 12 adenomas with hyperaldosteronism, three non-functioning adenomas and three adrenal cortical carcinomas.
  • RESULTS: The mean Ki-67 labeling index (LI) of adrenal cortical carcinomas was markedly higher than that of adrenal cortical adenomas (209.4 vs 8.7).
  • In functional adrenal cortical adenomas, the LI was significantly lower in adenomas with hyperaldosteronism than in those with Cushing syndrome (P = 0.004), although FCM results indicated that tetraploid patterns were more frequently observed in the former type.
  • Tumor size was significantly smaller in adenomas with hyperaldosteronism than in those with Cushing syndrome (P = 0.004).
  • Chromosome 17 showed disomy in all adrenal cortical adenomas, whereas chromosome 17 abnormalities were found in two of three adrenal cortical carcinomas.
  • CONCLUSIONS: Our study characterized various biological features of benign and malignant adrenal cortical tumors.
  • The use of a combination of markers might provide additional information to assist our understanding of the clinical behavior of an individual adrenal cortical tumor.
  • [MeSH-major] Adrenal Cortex Neoplasms / genetics. Adrenal Cortex Neoplasms / metabolism. Flow Cytometry. Immunohistochemistry. In Situ Hybridization, Fluorescence
  • [MeSH-minor] Adenoma / genetics. Adenoma / metabolism. Adenoma / pathology. Adult. Aged. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Carcinoma / genetics. Carcinoma / metabolism. Carcinoma / pathology. Cell Proliferation. Chromosomes, Human, Pair 17. Cushing Syndrome / genetics. Cushing Syndrome / metabolism. Cushing Syndrome / pathology. DNA, Neoplasm / genetics. Female. Humans. Hyperaldosteronism / genetics. Hyperaldosteronism / metabolism. Hyperaldosteronism / pathology. Ki-67 Antigen / metabolism. Male. Middle Aged. Ploidies. Tumor Suppressor Protein p53 / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15733104.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
  •  go-up   go-down


29. Onoda N, Ishikawa T, Nishio K, Tahara H, Inaba M, Wakasa K, Sumi T, Yamazaki T, Shigematsu K, Hirakawa K: Cushing's syndrome by left adrenocortical adenoma synchronously associated with primary aldosteronism by right adrenocortical adenoma: report of a case. Endocr J; 2009;56(3):495-502
MedlinePlus Health Information. consumer health - Cushing's Syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cushing's syndrome by left adrenocortical adenoma synchronously associated with primary aldosteronism by right adrenocortical adenoma: report of a case.
  • Synchronous associations of Cushing's syndrome (CS) and primary aldosteronism (PA) with multiple adrenocortical adenomas secreting each hormone independently have rarely been reported.
  • Bilateral adrenal masses with clinical symptoms of CS and PA were found in a 43-year-old woman.
  • The right adrenal tumor (3 cm) was yellow in color with abundant lipofuscin granules, and was composed of both eosinophilic compact cells and clear cells.
  • Left adrenal tumor (2.4 cm) was golden-yellow in color, and composed of clear cells only.
  • Furthermore, minute nodules were found at the surface of normal-appearing cortex on both sides of the adrenal glands, and the expression of HSD3B2 and CYP11B mRNAs was clearly demonstrated within the nodules, indicating aldosterone synthesis.
  • We diagnosed that the present case had 1) cortisol-producing right adrenocortical adenoma, 2) aldosterone producing left adrenocortical adenoma, and 3) cortical minute nodules with aldosterone production in both adrenal glands compatible with idiopathic adrenal hyperplasia.
  • We reviewed the cases reported, and discussed the significance of the minute nodules in the adrenal cortex, often found in association with the adrenocortical adenoma.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Cushing Syndrome / etiology. Hyperaldosteronism / etiology

  • Genetic Alliance. consumer health - Cushing's Syndrome.
  • Genetic Alliance. consumer health - Primary aldosteronism.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19270420.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 1.1.1.145 / 3 beta-hydroxysteroid dehydrogenase type II; EC 1.1.1.145 / Progesterone Reductase; EC 1.14.15.4 / Steroid 11-beta-Hydroxylase
  •  go-up   go-down


30. Garduno-García Jde J, Reza-Albarrán A, Márquez MA, Pérez FJ: [Adrenal adenoma as a cause of Cushing's syndrome: twenty years' experience in a referral center in Mexico]. Endocrinol Nutr; 2010 Nov;57(9):421-5
MedlinePlus Health Information. consumer health - Cushing's Syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adrenal adenoma as a cause of Cushing's syndrome: twenty years' experience in a referral center in Mexico].
  • [Transliterated title] Adenoma adrenal como etiología de síndrome de Cushing: veinte años de experiencia en un centro mexicano de tercer nivel.
  • Adrenal adenomas are an uncommon cause of adult CS.
  • OBJECTIVE: To describe the characteristics and outcome of patients with CS caused by adrenal adenomas in a referral center.
  • METHODS: We performed a retrospective cross-sectional observational study of patients with a diagnosis of CS caused by adrenal adenomas managed in our center over a 20-year period.
  • Our clinical experience in the diagnosis and treatment of this entity was analyzed.
  • The results of dynamic testing with dexamethasone suggested adrenal adenoma in 100% of the patients.
  • Seventy percent of adenomas were found in the left gland.
  • ACTH measurement in our center was not reliable in identifying adrenal adenoma as a cause of CS.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Cushing Syndrome / etiology

  • Genetic Alliance. consumer health - Cushing's Syndrome.
  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2010 SEEN. Published by Elsevier Espana. All rights reserved.
  • (PMID = 20863774.001).
  • [ISSN] 1579-2021
  • [Journal-full-title] Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición
  • [ISO-abbreviation] Endocrinol Nutr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


31. Ranganathan S, Lynshue K, Hunt JL, Kane T, Jaffe R: Unusual adrenal cortical tumor of unknown biologic potential: a nodule in a nodule in a nodule. Pediatr Dev Pathol; 2005 Jul-Aug;8(4):483-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual adrenal cortical tumor of unknown biologic potential: a nodule in a nodule in a nodule.
  • Adrenocortical tumors are uncommon neoplasms in childhood.
  • Most pediatric adrenal tumors are virilizing and carcinomas are more common than adenomas.
  • Recent molecular data suggest an adenoma-to-carcinoma progression sequence in adrenal cortical neoplasms.
  • We report a case of a 5-year-old boy who presented with virilizing symptoms secondary to an adrenal tumor that was resected laparoscopically.
  • The bulk of the tumor was a large, yellow mass with typical features of an adrenal cortical adenoma.
  • In the center was a well-circumscribed tan-brown nodule that was distinct from the adenoma and had oncocytic features.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16010500.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  •  go-up   go-down


32. Bovio S, Reimondo G, Daffara F, Allasino B, Angeli A, Terzolo M: [Subclinical Cushing's syndrome in adrenal incidentalomas]. Recenti Prog Med; 2006 Jan;97(1):6-15
Hazardous Substances Data Bank. HYDROCORTISONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Subclinical Cushing's syndrome in adrenal incidentalomas].
  • [Transliterated title] La sindrome di Cushing subclinica nei pazienti con incidentaloma surrenalico.
  • In the heyday of high-tech medicine, the incidental discovery of an adrenal mass is a frequent event owing to the routine use of sophisticated radiological techniques.
  • The potential harm to health associated with incidentally discovered cortical adenoma, the most frequent tumor among adrenal incidentalomas, is unclear at present.
  • Incidentally discovered adrenal adenoma may secrete cortisol autonomously, in a way that is no longer under close control by pituitary feedback, in 5 to 20% of cases.
  • At present, data are insufficient to indicate the superiority of a surgical or nonsurgical approach to manage patients with subclinical hyperfunctioning adrenal cortical adenoma.
  • It is of the utmost importance to establish collaborative prospective studies with clearly defined entry criteria and standardized evaluation protocols and treatment modalities to appraise the natural history and long-term morbidity of clinically inapparent adrenal adenoma and subclinical Cushing's syndrome.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Cushing Syndrome
  • [MeSH-minor] Adrenalectomy. Cardiovascular Diseases / etiology. Clinical Trials as Topic. Cross-Sectional Studies. Follow-Up Studies. Humans. Hydrocortisone / secretion. Hydrocortisone / urine. Incidental Findings. Insulin Resistance / genetics. Multicenter Studies as Topic. Phenotype. Prognosis. Risk Factors. Time Factors

  • Genetic Alliance. consumer health - Cushing's Syndrome.
  • MedlinePlus Health Information. consumer health - Cushing's Syndrome.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16535924.001).
  • [ISSN] 0034-1193
  • [Journal-full-title] Recenti progressi in medicina
  • [ISO-abbreviation] Recenti Prog Med
  • [Language] ita
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] WI4X0X7BPJ / Hydrocortisone
  • [Number-of-references] 87
  •  go-up   go-down


33. Lubikowski J, Umiński M, Andrysiak-Mamos E, Pynka S, Fuchs H, Wójcicki M, Szajko M, Moleda P, Post M, Zochowska E, Kiedrowicz B, Safranow K, Syrenicz A: From open to laparoscopic adrenalectomy: thirty years' experience of one medical centre. Endokrynol Pol; 2010 Jan-Feb;61(1):94-101
MedlinePlus Health Information. consumer health - Adrenal Gland Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Laparoscopic adrenalectomy (LA) has become the standardized treatment of benign adrenal lesions over the last two decades, making the indications to open adrenalectomy (OA) limited.
  • The purpose of this study was to show the thirty years of experience in open (OA) and laparoscopic adrenalectomy (LA) gained in one medical centre as well as to compare the results of OA and LA performed for benign adrenal lesions.
  • Analyzed factors included patients demographic data, ASA score, indication for surgery, tumour size and side, characteristics of the removed tumours, intraoperative and postoperative outcome of LA and OA, postoperative pain sensation, intraoperative and postoperative complications, and conversion rate from LA to OA.
  • The mean operative time was longer in the LA group (137 v. 82 min., p < 0.0001) and the blood loss was lower in LA group (110 v. 254 mL, p < 0.0001).
  • The mean time until resumption of normal diet was shorter after LA (22 v. 44 h), as was the mean time until ambulation (17 v. 36 h), mean length of the hospital stay (4.6 v. 6.8 days), and mean time until return to normal activities (14 v. 23 days, p < 0.0001 for each difference).
  • The analgesic requirement on the first and the second day postoperatively was lower in the LA group (p < 0.0001).
  • The rate of the conversion from LA to OA was 16%.
  • The histopathological diagnosis was adenoma of the adrenal gland in the majority of cases.
  • CONCLUSIONS: This study shows that LA is a safe, effective, and well-tolerated procedure.
  • It may be recommended as a "gold standard" surgery in a case of benign functioning or non-functioning adrenal tumours with diameter less than 8 cm. (Pol J Endocrinol 2010; 61 (1): 94-101).
  • [MeSH-major] Adrenal Gland Diseases / surgery. Adrenalectomy / methods. Laparoscopy / methods
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / surgery. Adult. Aged. Aged, 80 and over. Female. Humans. Length of Stay / statistics & numerical data. Male. Middle Aged. Poland. Treatment Outcome. Young Adult

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20205111.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  •  go-up   go-down


34. Nakamura A, Shimizu C, Nagai S, Taniguchi S, Umetsu M, Atsumi T, Wada N, Yoshioka N, Ono Y, Sasano H, Koike T: Unilateral adrenalectomy improves insulin resistance and polycystic ovaries in a middle-aged woman with virilizing adrenocortical adenoma complicated with Cushing's syndrome. J Endocrinol Invest; 2007 Jan;30(1):65-9
MedlinePlus Health Information. consumer health - Polycystic Ovary Syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral adrenalectomy improves insulin resistance and polycystic ovaries in a middle-aged woman with virilizing adrenocortical adenoma complicated with Cushing's syndrome.
  • A benign virilizing adrenal adenoma is rare among adrenal neoplasms in middle-aged women.
  • Abdominal computed tomography showed a left adrenal tumor, and an adrenocortical scintigraphy revealed uptake of the tracer on the left side.
  • Histopathological features of resected adrenal tumor were consistent with those of adrenocortical adenoma.
  • Cortical atrophy and reduced expression of DHEA-ST were detected in the cortex of the adjacent non-neoplastic adrenal gland.
  • This is a very rare case of virilizing adrenocortical adenoma complicated with Cushing's syndrome (CS).
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenalectomy. Adrenocortical Adenoma / complications. Cushing Syndrome / complications. Insulin Resistance. Polycystic Ovary Syndrome / therapy. Virilism / therapy

  • Genetic Alliance. consumer health - Cushing's Syndrome.
  • MedlinePlus Health Information. consumer health - Cushing's Syndrome.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] J Endocrinol Invest. 2008 Apr;31(4):380-1 [18475059.001]
  • (PMID = 17318025.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  •  go-up   go-down


35. Ng SS, Lee JF, Yiu RY, Li JC, Leung KL: Synchronous laparoscopic resection of colorectal and renal/adrenal neoplasms. Surg Laparosc Endosc Percutan Tech; 2007 Aug;17(4):283-6
MedlinePlus Health Information. consumer health - Kidney Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous laparoscopic resection of colorectal and renal/adrenal neoplasms.
  • Synchronous laparoscopic resections of coexisting abdominal diseases are shown to be feasible without additional postoperative morbidity.
  • We report our experience with synchronous laparoscopic resection of colorectal carcinoma and renal/adrenal neoplasms with an emphasis on surgical and oncologic outcomes.
  • Five patients diagnosed to have synchronous colorectal carcinoma and renal/adrenal neoplasms (renal cell carcinoma in 2 patients, adrenal cortical adenoma in 2 patients, and adrenal metastasis in 1 patient) underwent synchronous laparoscopic resection.
  • At a median follow-up of 17.6 months, no patient developed recurrence of disease.
  • Synchronous laparoscopic resection of colorectal and renal/adrenal neoplasms is technically feasible and safe.
  • [MeSH-major] Adrenal Cortex Neoplasms / surgery. Adrenocortical Adenoma / surgery. Carcinoma, Renal Cell / surgery. Colorectal Neoplasms / surgery. Kidney Neoplasms / surgery. Laparoscopy. Neoplasms, Multiple Primary / surgery

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17710049.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


36. Lombardi CP, Raffaelli M, Pani G, Maffione A, Princi P, Traini E, Galeotti T, Rossi ED, Fadda G, Bellantone R: Gene expression profiling of adrenal cortical tumors by cDNA macroarray analysis. Results of a preliminary study. Biomed Pharmacother; 2006 May;60(4):186-90
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene expression profiling of adrenal cortical tumors by cDNA macroarray analysis. Results of a preliminary study.
  • Adrenocortical carcinoma (ACC) are highly malignant tumors with poor prognosis.
  • To verify if it is possible to assess their differential gene expression by a cDNA macroarray analysis using RNA extracted from paraffin sections, we analyzed two different cohorts of adrenal cortical adenoma (ACA) and ACC.
  • Heat shock protein 60 (HSP-60) (ratio>2), Ciclin D1 and topoisomerase I (ratio>1.5) were overexpressed in the ACC cohort, while jun proto-oncogene was down-regulated. cDNA macroarray analysis from paraffin sections of adrenal tumors is feasible, despite with a low success rate.
  • [MeSH-major] Adrenal Cortex Neoplasms / genetics. Adrenocortical Carcinoma / genetics. Gene Expression Profiling. Gene Expression Regulation, Neoplastic / genetics. Oligonucleotide Array Sequence Analysis


37. Schittenhelm J, Jacob SN, Rutczynska J, Tsiflikas I, Meyermann R, Beschorner R: Extra-adrenal paravertebral myelolipoma mimicking a thoracic schwannoma. BMJ Case Rep; 2009;2009

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-adrenal paravertebral myelolipoma mimicking a thoracic schwannoma.
  • Myelolipoma of the adrenal gland is composed of both adipose tissue and normal haematopoietic elements.
  • Extra-adrenal myelolipomas are rare.
  • We present the case of a 63-year-old female patient with adenoma of the adrenal gland and an additional paravertebral lesion in the thoracic spine.
  • Post-mortem histopathology showed the incidental finding of a paravertebral myelolipoma.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Radiographics. 2005 Jan-Feb;25(1):69-85 [15653588.001]
  • [Cites] Am J Surg Pathol. 1982 Jun;6(4):363-74 [7051876.001]
  • [Cites] Arch Pathol Lab Med. 1994 Sep;118(9):895-6 [8080359.001]
  • [Cites] Radiographics. 1997 Nov-Dec;17(6):1373-85 [9397452.001]
  • (PMID = 21686745.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027965
  •  go-up   go-down


38. Pawlikowski M, Winczyk K, Sledź B: Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors. Folia Histochem Cytobiol; 2008;46(1):51-5
Hazardous Substances Data Bank. HYDROCORTISONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.
  • Angiotensin II is well known to affect the adrenal cell growth and function.
  • Angiotensin receptors AT1 and AT2 were found to be present in the normal adrenal gland.
  • However, the data on the expression of the angiotensin receptors in the adrenal tumors are very scarce.
  • To overcome this gap, the paraffin sections of the adrenal cortical tumors and of pheochromocytomas from the archival material were immunostained with antibodies raised against AT1 (sc-1173) and AT2 (sc-9040) receptor proteins.
  • In hyperplasia of the adrenal cortex and in benign adrenocortical adenomas, both functioning and non-functioning, the AT1 immunostaining was present mainly in the cell membranes.
  • A positive immunoreaction was also found in the subpopulation of cell nuclei and within the cytoplasm.
  • In the adrenal cancer, as well as in pheochromocytomas, neither cell membranes nor cell nuclei were immunostained with anti-AT1 antibody.
  • Our data indicates that the expression of AT1 receptors is altered in adrenal cancer and in pheochromocytomas.

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18296263.001).
  • [ISSN] 1897-5631
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Receptor, Angiotensin, Type 1; 0 / Receptor, Angiotensin, Type 2; 4964P6T9RB / Aldosterone; WI4X0X7BPJ / Hydrocortisone
  •  go-up   go-down


39. Park BK, Kim B, Ko K, Jeong SY, Kwon GY: Adrenal masses falsely diagnosed as adenomas on unenhanced and delayed contrast-enhanced computed tomography: pathological correlation. Eur Radiol; 2006 Mar;16(3):642-7
MedlinePlus Health Information. consumer health - CT Scans.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal masses falsely diagnosed as adenomas on unenhanced and delayed contrast-enhanced computed tomography: pathological correlation.
  • OBJECTIVES: To assess the accuracy of CT for the diagnosis of histologically confirmed adrenal adenoma and nonadenoma using CT numbers.
  • MATERIALS AND METHODS: Our study included 91 adrenal masses in 83 patients; histopathological diagnoses were 45 adenomas, 31 pheochromocytomas, 6 hyperplasias, 4 metastasis, and 5 miscellaneous lesions.
  • RESULTS: Sensitivity, specificity, and accuracy for adenoma were 40% (18/45), 91% (42/46), and 66% (60/91) with unenhanced CT, and 96% (24/25), 61% (11/18), and 81% (35/43) with DCE CT.
  • Adrenal masses falsely diagnosed as adenoma on unenhanced CT included three hyperplasias and one endothelial cyst, and those falsely diagnosed as adenoma on DCE CT were five pheochromocytomas, one oncocytic cortical tumor, and one primary pigmented nodular adrenocortical dysplasia.
  • Twenty-five lipid-poor adenomas were falsely diagnosed as nonadenomas on unenhanced CT and one degenerated adenoma both on unenhanced CT and on DCE CT.
  • CONCLUSION: Diagnosing adenoma merely on CT numbers can lead to misdiagnosis.
  • [MeSH-major] Adenoma / diagnostic imaging. Adrenal Gland Neoplasms / diagnostic imaging. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Analysis of Variance. Contrast Media. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Hyperplasia. Male. Middle Aged. Neoplasm Metastasis. Pheochromocytoma / diagnostic imaging. Pheochromocytoma / pathology. Sensitivity and Specificity

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [ErratumIn] Eur Radiol. 2006 Mar;16(3):768
  • [Cites] AJR Am J Roentgenol. 2003 Sep;181(3):843-9 [12933492.001]
  • [Cites] Endocr J. 2004 Feb;51(1):89-95 [15004414.001]
  • [Cites] Radiology. 2005 Feb;234(2):479-85 [15671003.001]
  • [Cites] Radiology. 1998 May;207 (2):369-75 [9577483.001]
  • [Cites] Am J Med. 1996 Jul;101(1):88-94 [8686720.001]
  • [Cites] Radiology. 1996 Sep;200(3):743-7 [8756925.001]
  • [Cites] AJR Am J Roentgenol. 1999 Apr;172(4):997-1002 [10587135.001]
  • [Cites] Eur Radiol. 2004 Oct;14(10):1787-92 [15241622.001]
  • [Cites] AJR Am J Roentgenol. 1998 Jul;171(1):201-4 [9648789.001]
  • [Cites] Radiology. 1997 Mar;202(3):693-6 [9051018.001]
  • [Cites] Radiology. 2000 Dec;217(3):798-802 [11110946.001]
  • [Cites] J Comput Assist Tomogr. 1994 May-Jun;18(3):432-8 [8188912.001]
  • [Cites] Radiology. 2002 Mar;222(3):629-33 [11867777.001]
  • [Cites] AJR Am J Roentgenol. 1995 Dec;165(6):1453-9 [7484585.001]
  • [Cites] AJR Am J Roentgenol. 2000 Nov;175(5):1411-5 [11044054.001]
  • [Cites] AJR Am J Roentgenol. 1998 Mar;170(3):747-52 [9490968.001]
  • [Cites] J Clin Endocrinol Metab. 1999 Feb;84(2):520-6 [10022410.001]
  • (PMID = 16215735.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  •  go-up   go-down


40. Bagwan IN, Cook G, Mudan S, Wotherspoon A: Unusual presentation of metastatic adenocarcinoma. World J Surg Oncol; 2007;5:116
MedlinePlus Health Information. consumer health - Esophageal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The most common tumours of the adrenal gland are adenoma, pheochromocytoma, adrenocortical carcinoma, and metastases.
  • Although the imaging features of these tumours are established, the imaging characteristics of uncommon adrenal masses are less well known.
  • In patients with extradrenal tumour, incidental discovery of an adrenal mass necessitates excluding the possibility of metastatic malignancy.
  • Sixteen months later on staging CT scan a 2 x 2 cm adrenal mass was detected, which increased in size over a period of time to 3 x 3 cm in size.
  • Adrenalectomy was performed and histological examination revealed metastatic adenocarcinoma within an adrenal adenoma.
  • CONCLUSION: The present case highlights the unusual behaviour of an oesophageal adenocarcinoma causing metastasis to an adrenocortical adenoma.
  • [MeSH-major] Adenocarcinoma / secondary. Adrenal Gland Neoplasms / secondary. Esophageal Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Endocr J. 2005 Dec;52(6):785-8 [16410674.001]
  • [Cites] Cancer. 2006 Apr 1;106(7):1624-33 [16518827.001]
  • [Cites] J Nucl Med. 2001 Dec;42(12):1795-9 [11752075.001]
  • [Cites] Ann Intern Med. 2003 Mar 4;138(5):424-9 [12614096.001]
  • [Cites] AJR Am J Roentgenol. 1996 Oct;167(4):891-2 [8819376.001]
  • [Cites] Surgery. 2004 Dec;136(6):1289-96 [15657589.001]
  • [Cites] J Clin Endocrinol Metab. 2005 Aug;90(8):4924-9 [15914530.001]
  • (PMID = 17949483.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2100056
  •  go-up   go-down


41. Jeong BC, Park YH, Han DH, Kim HH: Laparoendoscopic single-site and conventional laparoscopic adrenalectomy: a matched case-control study. J Endourol; 2009 Dec;23(12):1957-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: The purpose of this study was to describe our initial clinical experience and assess the feasibility of laparoendoscopic single-site surgery (LESS) in the treatment of benign adrenal adenoma.
  • PATIENTS AND METHODS: Nine patients undergoing LESS adrenalectomy for benign adrenal adenoma were compared with 17 patients undergoing conventional laparoscopic adrenalectomy.
  • CONCLUSIONS: LESS adrenalectomy for benign adrenal adenoma is comparable to the conventional laparoscopic approach with regard to the operative time, blood loss, length of hospital stay, and degree of complication, and has demonstrated more desirable cosmetic outcomes.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19909074.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


42. Kojima Y, Miyake O, Morimoto A, Kawamura C, Katayama S: [A case of aldosterone-producing adenoma associated with end-stage renal disease]. Hinyokika Kiyo; 2010 Jan;56(1):21-4
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of aldosterone-producing adenoma associated with end-stage renal disease].
  • Abdominal computed tomography and magnetic resonance imaging confirmed a right adrenal tumor.
  • Furthermore, adrenal scintigraphy after dexamethasone inhibition showed accumulation in the right adrenal gland.
  • Under a diagnosis of aldosterone-producing adrenal tumor, laparoscopic right adrenalectomy was performed.
  • Pathological findings showed adrenal cortical adenoma.
  • Primary aldosteronism causes hypertension, hypopotassiumemia, hyporeninemia, and hyperaldosteronemia via excessive secretion of aldosterone in the adrenal glands.
  • A previous study also indicated the presence of hyperaldosteronemia in patients with end-stage renal disease.
  • A diagnosis should be carefully made.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Aldosterone / biosynthesis. Kidney Failure, Chronic / complications

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • MedlinePlus Health Information. consumer health - Kidney Failure.
  • Hazardous Substances Data Bank. POTASSIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20104005.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone; RWP5GA015D / Potassium
  •  go-up   go-down


43. Bernini GP, Moretti A, Mannelli M, Ercolino T, Bardini M, Caramella D, Taurino C, Salvetti A: Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, hepatic and vertebral hemangiomas in a patient with a new intronic variant in the VHL gene. J Endocrinol Invest; 2005 Dec;28(11):1032-7
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, hepatic and vertebral hemangiomas in a patient with a new intronic variant in the VHL gene.
  • This was characterized by right adrenal pheochromocytoma associated with homolateral ganglioneuroma and controlateral adrenal cortical adenoma.
  • Accordingly, the patient showed no sign or symptom of endocrine disease.
  • Computed tomography (CT) and magnetic resonance (MR) demonstrated a typical adenomatous lesion on the left adrenal gland with precocious uptake of the radiotracer on radioidine (131I)-norcholesterol adrenal scintigraphy, while the controlateral gland showed hyperdensity on CT, hyperintensity on MR and no uptake at adrenal scintigraphy.
  • The right adrenal gland was surgically removed and, microscopically, pheochromocytoma and ganglioneuroma areas appeared intermixed without a predominant component.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Adrenocortical Adenoma / genetics. Ganglioneuroma / genetics. Hemangioma / genetics. Liver Neoplasms / genetics. Neoplasms, Multiple Primary. Pheochromocytoma / genetics. Spinal Neoplasms / genetics. Von Hippel-Lindau Tumor Suppressor Protein / genetics
  • [MeSH-minor] Adrenal Cortex Neoplasms / genetics. Adrenal Cortex Neoplasms / pathology. Aged. DNA, Neoplasm / analysis. Female. Genetic Variation. Humans. Introns / genetics. Magnetic Resonance Imaging. Tomography, X-Ray Computed


44. Inoue T, Ishiguro K, Suda T, Ito N, Suzuki Y, Taniguchi Y, Ohgi S: Laparoscopic bilateral partial adrenalectomy for adrenocortical adenomas causing Cushing's syndrome: report of a case. Surg Today; 2006;36(1):94-7
MedlinePlus Health Information. consumer health - Cushing's Syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic bilateral partial adrenalectomy for adrenocortical adenomas causing Cushing's syndrome: report of a case.
  • Laparoscopic total adrenalectomy has become a standard technique for small adrenal tumors; however, bilateral adrenalectomy results in postoperative adrenal insufficiency, necessitating lifelong steroid replacement.
  • To preserve adrenocortical function in a 41-year-old woman with bilateral adrenocortical adenoma (BAA) causing Cushing's syndrome, we performed laparoscopic bilateral partial adrenalectomy.
  • We based our preoperative diagnosis of bilateral adrenocortical tumors causing Cushing's syndrome on the results of endocrinological investigations and imaging findings.
  • Thus, we performed lateral transperitoneal laparoscopic bilateral partial adrenalectomy, preserving the adrenal glands, which were normal.
  • Pathological examination of both tumors confirmed the diagnosis of adrenocortical adenoma.
  • The patient had no postoperative complications, and her adrenocortical function was normal without steroid replacement at her 10-month follow-up.
  • This report shows that Cushing's syndrome resulting from bilateral adenomas can be effectively treated by laparoscopic bilateral partial adrenalectomy as a minimally invasive, adrenocortical-preserving operation.
  • [MeSH-major] Adrenalectomy / methods. Adrenocortical Adenoma / surgery. Cushing Syndrome / etiology. Laparoscopy

  • Genetic Alliance. consumer health - Cushing's Syndrome.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] World J Surg. 2000 Jan;24(1):108-13 [10594213.001]
  • [Cites] Surgery. 2003 Dec;134(6):1066-72; discussion 1072-3 [14668742.001]
  • [Cites] Endocr J. 1997 Aug;44(4):533-40 [9447286.001]
  • [Cites] J Endourol. 2002 Oct;16(8):591-7 [12470468.001]
  • [Cites] Urology. 2002 Dec;60(6):1100-3 [12475679.001]
  • [Cites] J Urol. 2000 Jul;164(1):14-7 [10840414.001]
  • [Cites] ANZ J Surg. 2003 Aug;73(8):664-6 [12887546.001]
  • [Cites] Surg Today. 1994;24(6):538-43 [7919738.001]
  • [Cites] Eur Urol. 2000 Sep;38(3):344-8 [10940711.001]
  • [Cites] Endocr J. 2003 Apr;50(2):155-62 [12803235.001]
  • [Cites] Acta Endocrinol (Copenh). 1985 Feb;108(2):245-54 [3969816.001]
  • (PMID = 16378204.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


45. Lee R, Storr M, Hershfield NB: A case of Conn's syndrome revealed after oral sodium phosphate (Fleet) preparation for colonoscopy. J Dig Dis; 2010 Apr;11(2):111-4
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of Conn's syndrome revealed after oral sodium phosphate (Fleet) preparation for colonoscopy.
  • The patient was subsequently diagnosed with primary aldosteronism secondary to an adenoma of the adrenal gland.
  • Bilateral adrenal venous sampling revealed excessive levels of aldosterone in the left adrenal vein prior to definitive surgery.
  • This case indicates that an oral sodium phosphate bowel preparation, though safe for most patients, can be complicated by a previously not diagnosed endocrine disease like the primary aldosteronism (Conn's syndrome) reported here.
  • This is the first report of a Conn's syndrome diagnosed after bowel cleansing with a sodium phosphate solution.
  • [MeSH-major] Colonoscopy / methods. Hyperaldosteronism / chemically induced. Hyperaldosteronism / diagnosis. Phosphates / adverse effects
  • [MeSH-minor] Adenoma / complications. Adenoma / diagnosis. Administration, Oral. Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / diagnosis. Aldosterone / blood. Female. Humans. Middle Aged. Renin / blood

  • Genetic Alliance. consumer health - Conn's Syndrome.
  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20402838.001).
  • [ISSN] 1751-2980
  • [Journal-full-title] Journal of digestive diseases
  • [ISO-abbreviation] J Dig Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Phosphates; 4964P6T9RB / Aldosterone; EC 3.4.23.15 / Renin; SE337SVY37 / sodium phosphate
  •  go-up   go-down


46. Giallauria F, De Lorenzo A, Manakos A, Pilerci F, Psaroudaki M, De Cristofaro A, Lucci R, Del Forno D, Vigorito C: [Inflammatory syndrome after thoracic aortic endoprosthesis implantation associated with cortico-suprarenal adenoma]. Monaldi Arch Chest Dis; 2005 Mar;64(1):59-62
MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Inflammatory syndrome after thoracic aortic endoprosthesis implantation associated with cortico-suprarenal adenoma].
  • [Transliterated title] Sindrome infiammatoria post-impianto di endoprotesi aortica toracica associata ad adenoma surrenalico.
  • We report a case of a 68-year-old patient, admitted with diagnosis of aneurysm of the descending thoracic aorta to the Department of Cardiac Surgery, where he underwent percutaneous endovascular application of 4 endoprostheses in the descending thoracic aorta.
  • Further investigations showed left cortical-suprarenal adenoma.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16128168.001).
  • [ISSN] 1122-0643
  • [Journal-full-title] Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
  • [ISO-abbreviation] Monaldi Arch Chest Dis
  • [Language] ITA
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


47. Li Q, Zhang XQ, Nie L, Chen GS, Li H, Zhang F, Zhang LY, Hong L, Wang SF, Wang H: Expression of interferon-gamma in human adrenal gland and kidney tumours. Br J Cancer; 2007 Aug 6;97(3):420-5
MedlinePlus Health Information. consumer health - Kidney Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of interferon-gamma in human adrenal gland and kidney tumours.
  • Our previous studies have shown that IFN-gamma-like immunoreactivity also appears in human adrenal cortical tumour and phaeochromocytoma.
  • To investigate whether human tumour cells can produce IFN-gamma, we examined 429 biopsy specimens of 30 kinds of tumour and tumour-surrounding tissues in adrenal glands and in kidneys by using immunohistochemistry and in situ hybridisation.
  • IFN-gamma immunoactivity was shown in 34.3% of the adrenal cortical adenomas, 50% of the adrenal cortical carcinomas, 26.7% of the phaeochromocytomas, 26.7% of the clear cell renal cell carcinomas (RCCs), 22% of the adrenal cortexes and 40% of medullas adjacent to tumours.
  • Western blot analysis has further confirmed the immunohistochemistry results by showing a distinct IFN-gamma band corresponding to 17.4 kDa in tissue extracts from adrenal cortical adenoma, phaeochromocytoma and clear cell RCCs.
  • [MeSH-major] Adrenal Gland Neoplasms / metabolism. Interferon-gamma / metabolism. Kidney Neoplasms / metabolism

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Leuk Lymphoma. 1998 Feb;28(5-6):459-67 [9613975.001]
  • [Cites] Immunity. 2004 Aug;21(2):137-48 [15308095.001]
  • [Cites] Cytokine Growth Factor Rev. 1998 Jun;9(2):117-23 [9754706.001]
  • [Cites] J Pathol. 1999 Mar;187(4):475-80 [10398109.001]
  • [Cites] Cancer Res. 2005 Apr 15;65(8):3447-53 [15833880.001]
  • [Cites] Nat Immunol. 2005 Jul;6(7):722-9 [15951814.001]
  • [Cites] J Gen Virol. 1986 Jun;67 ( Pt 6):1059-71 [2423637.001]
  • [Cites] J Exp Med. 1987 Sep 1;166(3):798-803 [3114409.001]
  • [Cites] J Neurol Sci. 1988 Apr;84(2-3):257-64 [3132537.001]
  • [Cites] Brain Res. 1989 Dec 18;504(2):306-10 [2513088.001]
  • [Cites] Neuroscience. 1991;45(3):551-60 [1775233.001]
  • [Cites] J Heart Lung Transplant. 1992 Jan-Feb;11(1 Pt 1):142-6 [1540602.001]
  • [Cites] Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3725-9 [8097322.001]
  • [Cites] Zhonghua Bing Li Xue Za Zhi. 1995 Dec;24(6):372-4 [8732096.001]
  • [Cites] Semin Oncol. 1998 Feb;25(1 Suppl 1):14-22 [9482536.001]
  • [Cites] Cancer Res. 1998 Feb 15;58(4):840-7 [9485044.001]
  • [Cites] J Pathol. 1998 Feb;184(2):169-76 [9602708.001]
  • [Cites] Nat Rev Immunol. 2006 Nov;6(11):836-48 [17063185.001]
  • [Cites] J Immunol. 2000 Jan 1;164(1):64-71 [10604994.001]
  • [Cites] J Immunol. 2000 Feb 1;164(3):1286-92 [10640742.001]
  • [Cites] J Interferon Cytokine Res. 2000 Apr;20(4):403-9 [10805375.001]
  • [Cites] Annu Rev Immunol. 2000;18:451-94 [10837066.001]
  • [Cites] Hepatology. 2000 Sep;32(3):491-500 [10960440.001]
  • [Cites] Cancer Res. 2000 Oct 15;60(20):5789-96 [11059775.001]
  • [Cites] Blood. 2001 Jan 1;97(1):192-7 [11133760.001]
  • [Cites] Nature. 2001 Apr 26;410(6832):1107-11 [11323675.001]
  • [Cites] Cytokine Growth Factor Rev. 2002 Apr;13(2):95-109 [11900986.001]
  • [Cites] J Pathol. 2002 May;197(1):89-97 [12081209.001]
  • [Cites] Immunol Lett. 2002 Dec 3;84(3):163-72 [12413732.001]
  • [Cites] Br J Cancer. 2003 Sep 1;89(5):915-21 [12942126.001]
  • [Cites] Annu Rev Immunol. 2004;22:329-60 [15032581.001]
  • [Cites] Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7556-61 [9636188.001]
  • (PMID = 17622250.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 82115-62-6 / Interferon-gamma
  • [Other-IDs] NLM/ PMC2360327
  •  go-up   go-down


48. Contesse V, Reznik Y, Louiset E, Duparc C, Cartier D, Sicard F, Laquerriere A, Parmentier F, Kuhn JM, Vaudry H, Lefebvre H: Abnormal sensitivity of cortisol-producing adrenocortical adenomas to serotonin: in vivo and in vitro studies. J Clin Endocrinol Metab; 2005 May;90(5):2843-50
Hazardous Substances Data Bank. HYDROCORTISONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abnormal sensitivity of cortisol-producing adrenocortical adenomas to serotonin: in vivo and in vitro studies.
  • Two patients with incidentally discovered adrenocortical adenomas underwent a series of pharmacological and physiological tests after pretreatment with dexamethasone.
  • In the two cases, 5-HT stimulated cortisol secretion from tumor cells with increased efficacy and/or potency to activate steroidogenesis by comparison with normal adrenocortical cells.
  • In the two adenoma tissues, immunohistochemical studies revealed the presence of 5-HT-like immunoreactivity within clusters of steroidogenic cells, suggesting that 5-HT acted through an autocrine/paracrine mechanism to stimulate steroidogenesis.
  • In conclusion, this study provides the first observation of adrenocortical cortisol-producing adenomas hypersensitive in vivo and in vitro to serotonergic agonists.
  • Our results also show that cortisol-producing adenomas can express simultaneously several illegitimate receptors.
  • [MeSH-major] Adenoma / metabolism. Adrenocortical Adenoma / metabolism. Hydrocortisone / secretion. Serotonin / pharmacology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Horm Metab Res. 2005 Aug;37(8):528-9 [16138268.001]
  • (PMID = 15705918.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 158165-40-3 / Receptors, Serotonin, 5-HT4; 333DO1RDJY / Serotonin; WI4X0X7BPJ / Hydrocortisone
  •  go-up   go-down


49. Guthoff M, Schnauder G, Kirchhoff K, Kurth R, Horger M, Müssig K: [Normokalaemic primary aldosteronism due to an aldosterone-producing adrenal adenoma--Case 06/2009]. Dtsch Med Wochenschr; 2009 Jul;134(31-32):1582
Genetic Alliance. consumer health - Primary aldosteronism.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Normokalaemic primary aldosteronism due to an aldosterone-producing adrenal adenoma--Case 06/2009].
  • INVESTIGATIONS: Ultrasound displayed no evidence of renal artery stenosis.
  • Renal function was normal.
  • MRI revealed an adenoma of the right adrenal gland.
  • DIAGNOSIS, TREATMENT AND COURSE: The results were consistent with primary aldosteronism due to an aldosterone-producing adenoma of the adrenal gland.
  • The histological findings confirmed an adenoma of the adrenal gland.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Hyperaldosteronism / etiology
  • [MeSH-minor] Adrenalectomy / methods. Adult. Aldosterone / blood. Aldosterone / secretion. Diagnosis, Differential. Humans. Hypertension / etiology. Laparoscopy. Magnetic Resonance Imaging. Male. Renin / blood

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19629922.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone; EC 3.4.23.15 / Renin
  •  go-up   go-down


50. Calsyn JD, Green RA, Davis GJ, Reilly CM: Adrenal pheochromocytoma with contralateral adrenocortical adenoma in a cat. J Am Anim Hosp Assoc; 2010 Jan-Feb;46(1):36-42
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal pheochromocytoma with contralateral adrenocortical adenoma in a cat.
  • An ultrasound revealed bilateral adrenal gland enlargement.
  • Histopathology was consistent with a cortical adenoma in the right adrenal gland and a pheochromocytoma in the left adrenal gland.
  • [MeSH-major] Adrenal Gland Neoplasms / veterinary. Adrenocortical Adenoma / veterinary. Cat Diseases / diagnosis. Pheochromocytoma / veterinary

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • MedlinePlus Health Information. consumer health - Pheochromocytoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20045835.001).
  • [ISSN] 1547-3317
  • [Journal-full-title] Journal of the American Animal Hospital Association
  • [ISO-abbreviation] J Am Anim Hosp Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


51. Ilias I, Sahdev A, Reznek RH, Grossman AB, Pacak K: The optimal imaging of adrenal tumours: a comparison of different methods. Endocr Relat Cancer; 2007 Sep;14(3):587-99
MedlinePlus Health Information. consumer health - Diagnostic Imaging.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The optimal imaging of adrenal tumours: a comparison of different methods.
  • Computed tomography (CT; unenhanced, followed by contrast-enhanced examinations) is the cornerstone of imaging of adrenal tumours.
  • Attenuation values of <10 Hounsfield units on an unenhanced CT are practically diagnostic for adenomas.
  • Functional nuclear medicine imaging is useful for adrenal lesions that are not adequately characterised with CT and MRI.
  • Scintigraphy with [(131)I]-6-iodomethyl norcholesterol (a labelled cholesterol analogue) can differentiate adrenal cortical adenomas from carcinomas.
  • The specific and useful roles of adrenal imaging include the characterisation of tumours, assessment of true tumour size, differentiation of adenomas from carcinomas and metastases, and differentiation of hyperfunctioning from non-functioning lesions.
  • Adrenal imaging complements and assists the clinical and hormonal evaluation of adrenal tumours.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Diagnostic Imaging / methods
  • [MeSH-minor] Adrenal Cortex Neoplasms / diagnosis. Adrenal Cortex Neoplasms / pathology. Adrenal Medulla / pathology. Adrenocortical Hyperfunction / diagnosis. Diagnosis, Differential. Ganglioneuroma / diagnosis. Ganglioneuroma / pathology. Hemangioma / diagnosis. Hemangioma / pathology. Hemangiosarcoma / diagnosis. Hemangiosarcoma / pathology. Humans. Leiomyosarcoma / diagnosis. Leiomyosarcoma / pathology. Lymphoma / diagnosis. Lymphoma / pathology. Magnetic Resonance Imaging. Myelolipoma / diagnosis. Myelolipoma / pathology. Neoplasm Metastasis. Neuroblastoma / diagnosis. Neuroblastoma / pathology. Pheochromocytoma / diagnosis. Pheochromocytoma / pathology. Tomography, X-Ray Computed. Whole Body Imaging

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17914090.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 61
  •  go-up   go-down


52. Ermetici F, Malavazos AE, Corbetta S, Morricone L, Dall'Asta C, Corsi MM, Ambrosi B: Adipokine levels and cardiovascular risk in patients with adrenal incidentaloma. Metabolism; 2007 May;56(5):686-92
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adipokine levels and cardiovascular risk in patients with adrenal incidentaloma.
  • Adrenal incidentalomas (AIs) have been associated with an increased incidence of several cardiovascular risk factors, similar to overt Cushing syndrome.
  • Plasma IL-6, adiponectin, resistin, TNF-alpha, and MCP-1 levels were measured in 20 healthy subjects (6 males; 14 females; age, 58.5 +/- 2.2 years; body mass index, 28.1 +/- 0.9 kg/m(2)) and in 20 patients (5 males; 15 females; age, 57.9 +/- 2.0 years; body mass index, 28.0 +/- 0.8 kg/m(2)) with AI and typical computed tomographic features of cortical adenoma, who were not affected by diabetes mellitus, hypertension, or other relevant diseases.
  • In conclusion, patients with AI may show increased levels of adipokines (apparently not related to the presence of diabetes, hypertension, or obesity), which may be affected by the presence of the adrenal adenoma.
  • For some adipokines, a direct production from the adrenal gland may be hypothesized even if other studies are needed to better investigate the role of adipokines in states of altered cortisol secretion.
  • [MeSH-major] Adrenal Cortex Neoplasms / blood. Adrenocortical Adenoma / blood. Atherosclerosis / blood

  • MedlinePlus Health Information. consumer health - Atherosclerosis.
  • COS Scholar Universe. author profiles.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • Hazardous Substances Data Bank. DEXAMETHASONE .
  • Hazardous Substances Data Bank. HYDROCORTISONE .
  • Hazardous Substances Data Bank. Corticotropin .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17445545.001).
  • [ISSN] 0026-0495
  • [Journal-full-title] Metabolism: clinical and experimental
  • [ISO-abbreviation] Metab. Clin. Exp.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ADIPOQ protein, human; 0 / Adiponectin; 0 / Chemokine CCL2; 0 / Glucocorticoids; 0 / Interleukin-6; 0 / RETN protein, human; 0 / Resistin; 0 / Tumor Necrosis Factor-alpha; 7S5I7G3JQL / Dexamethasone; 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone
  •  go-up   go-down


53. Monjero-Ares I, Gegundez-Gómez C, Couselo-Villanueva JM, Moreda-Pérez M, Jorge-Iglesias M, Torres-García I, Alvarez-Gutiérrez AE, Arija-Val JF: [Association of pheochromocytoma with contralateral nonfunctioning adrenal adenoma]. Cir Esp; 2006 Feb;79(2):126-8
MedlinePlus Health Information. consumer health - Pheochromocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Association of pheochromocytoma with contralateral nonfunctioning adrenal adenoma].
  • [Transliterated title] Asociación de feocromocitoma con adenoma suprarrenal contralateral no funcionante.
  • A 52-year-old woman complaining of abdominal pain, headaches and palpitations was admitted to our hospital for investigation of a bilateral adrenal tumor.
  • The definitive diagnosis was right pheochromocytoma and left adrenocortical adenoma.
  • Only four cases of pheochromocytoma associated with nonfunctioning adrenal adenoma have previously been reported.
  • [MeSH-major] Adenoma. Adrenal Gland Neoplasms. Neoplasms, Multiple Primary. Pheochromocytoma

  • Genetic Alliance. consumer health - Pheochromocytoma.
  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16539953.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


54. Denzinger S, Burger M, Hartmann A, Hofstaedter F, Wieland WF, Ganzer R: Spontaneous rupture of a benign giant adrenal adenoma. APMIS; 2007 Apr;115(4):381-4
MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous rupture of a benign giant adrenal adenoma.
  • We report on a 50-year-old patient with a giant benign adenoma of the adrenal cortex, which ruptured spontaneously, leading to life-threatening retroperitoneal hemorrhage.
  • Following emergency adrenalectomy with sparing of the ipsilateral kidney, an adenoma of the adrenal cortex with a diameter of 18 cm and a weight of 1400 g was found.
  • A detailed literature search showed this to be the largest benign tumor of the adrenal cortex described so far.
  • We discuss the diagnosis and treatment of this unusual tumor.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis
  • [MeSH-minor] Humans. Middle Aged. Rupture, Spontaneous / diagnosis. Rupture, Spontaneous / pathology. Rupture, Spontaneous / surgery. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17504308.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  •  go-up   go-down


55. Tan HS, Thai AC, Nga ME, Mukherjee JJ: Development of ipsilateral adrenocortical carcinoma sixteen years after resection of an adrenal tumour causing Cushing's syndrome. Ann Acad Med Singapore; 2005 Apr;34(3):271-4
MedlinePlus Health Information. consumer health - Cushing's Syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Development of ipsilateral adrenocortical carcinoma sixteen years after resection of an adrenal tumour causing Cushing's syndrome.
  • INTRODUCTION: At times, it may be difficult to differentiate early stage, low-grade adrenocortical carcinoma from benign adrenal adenoma.
  • CLINICAL PICTURE: A 53-year-old lady underwent right adrenalectomy for a 4-cm adrenocortical tumour causing Cushing's syndrome.
  • Histology revealed an adrenocortical adenoma.
  • Sixteen years later, she presented with a 14-cm adrenal tumour, again on the right side.
  • Histology confirmed adrenocortical carcinoma.
  • OUTCOME: She died of metastatic disease 17 months later.
  • CONCLUSIONS: This case highlights the importance of long-term, systematic follow-up of patients treated for benign adrenal adenomas, especially if the tumour size exceeds 4 cm.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Carcinoma / pathology. Cushing Syndrome / etiology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adrenocortical Adenoma / pathology. Diagnosis, Differential. Fatal Outcome. Female. Humans. Middle Aged

  • Genetic Alliance. consumer health - Cushing's Syndrome.
  • Genetic Alliance. consumer health - Adrenocortical Carcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15902349.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  •  go-up   go-down


56. Przybylik-Mazurek E, Buziak-Bereza M, Fedorowicz A, Kuźniarz-Rymarz S, Stochmal E, Hubalewska-Dydejczyk A: [Retrospective hormonal analysis of incidentally discovered and operated adrenal tumors for subclinical Cushing's syndrome]. Przegl Lek; 2010;67(12):1270-5
Hazardous Substances Data Bank. HYDROCORTISONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Retrospective hormonal analysis of incidentally discovered and operated adrenal tumors for subclinical Cushing's syndrome].
  • In the last twenty years the introduction of new imaging techniques has caused increasing incidence of accidental detection of adrenal tumors, which are usually mild and in most cases are hormonally inactive adenomas.
  • Among hormonal disorders in patients with adrenal incidentalomas the hypercortisolism is often described, which, if not treated properly, leads to multiple organ complications, and further to the patient's death.
  • The aim of the study was the retrospective analysis of the group of patients with adrenal incidentaloma, verified by histopathology for assessment of subclinical Cushing's syndrome.
  • Among the group of 225 patients: 62 men and 163 women with incidentally detected adrenal tumors in age from 19 to 81 years diagnosed and treated in the Department of Clinical Endocrinology, University Hospital in Krakow, 59 patients was sent to surgery: 15 men and 42 women.
  • Group A consisted of patients with adrenal cortical adenoma: 38 people (11 men and 27 women).
  • In group B there were people with so-called other hormonal inactive adrenal tumors - 17 people (4 men and 13 women).
  • In group A the mean morning level of cortisol was 18.23 +/- 6.42 ug/dl and did not differ statistically significantly from the results of group B (mean morning cortisol level of 15.86 +/- 4.6 ug/dl).
  • A detailed analysis of the clinical signs, meticulously carried out and repeated hormonal diagnosis with the use of functional tests should be focused on the detection of subclinical hormonal disorders, which is crucial in preventing organ damage and making a decision of the right treatment of the patient, which is surgical.
  • [MeSH-major] Adrenal Gland Neoplasms / blood. Adrenal Gland Neoplasms / surgery. Hydrocortisone / blood

  • Genetic Alliance. consumer health - Cushing's Syndrome.
  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21591352.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] WI4X0X7BPJ / Hydrocortisone; Adrenal incidentaloma
  •  go-up   go-down


57. Sangoi AR, McKenney JK: A tissue microarray-based comparative analysis of novel and traditional immunohistochemical markers in the distinction between adrenal cortical lesions and pheochromocytoma. Am J Surg Pathol; 2010 Mar;34(3):423-32
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A tissue microarray-based comparative analysis of novel and traditional immunohistochemical markers in the distinction between adrenal cortical lesions and pheochromocytoma.
  • We have encountered an increasing number of image-guided adrenal mass biopsies in which the differential diagnosis is adrenal cortical lesion versus pheochromocytoma.
  • In this study, a detailed immunoprofile of 63 adrenal cortical lesions (3 adrenal rests, 6 adrenal cortical hyperplasias, 43 adrenal cortical adenomas, 4 adrenal cortical neoplasms of uncertain malignant potential, and 7 adrenal cortical carcinomas) was compared with 35 pheochromocytomas using traditional (calretinin, chromogranin, inhibin, melanA, and synaptophysin) and novel [steroidogenic factor-1 (SF-1), microtubule-associated protein 2, and mammalian achaete-scute homolog-1] antibodies, using tissue microarray technology to simulate small image-guided biopsies.
  • A comparison of sensitivity and specificity using different intensity thresholds required for a "positive" result (> or = 1+ vs. > or = 2+) was performed.
  • Staining results based on a > or = 1+ and (> or = 2+) intensity threshold were as follows: calretinin-95% (89%) in adrenal cortical lesions and 14% (0%) in pheochromocytomas; chromogranin-0% in adrenal cortical lesions and 100% in pheochromocytomas; inhibin-97% (86%) in adrenal cortical lesions and 6% (0%) in pheochromocytomas; microtubule-associated protein 2-29% (16%) in adrenal cortical lesions and 100% (89%) in pheochromocytomas; mammalian achaete-scute homolog-1-0% in both adrenal cortical lesions and pheochromocytomas; melanA-94% (86%) in adrenal cortical lesions and 6% (0%) in pheochromocytomas; SF-1-87% (86%) in adrenal cortical lesions and 0% in pheochromocytomas; synaptophysin-67% (59%) in adrenal cortical lesions and 100% in pheochromocytomas.
  • Using an antibody panel consisting of chromogranin plus the nuclear antibody SF-1 and either calretinin or inhibin, while requiring a high-staining intensity threshold, helps to eliminate interpretative issues of artifactual or background reactivity, improves diagnostic sensitivity/specificity, and makes for an effective immunohistochemical approach in distinguishing adrenal cortical lesions from pheochromocytomas.
  • [MeSH-major] Adenoma / chemistry. Adrenal Cortex Neoplasms / chemistry. Adrenal Gland Neoplasms / chemistry. Biomarkers, Tumor / analysis. Carcinoma / chemistry. Immunohistochemistry. Pheochromocytoma / chemistry. Tissue Array Analysis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Artifacts. Biopsy. Calbindin 2. Child. Child, Preschool. Chromogranins / analysis. Diagnosis, Differential. Female. Humans. Infant. Inhibins / analysis. Male. Middle Aged. Predictive Value of Tests. S100 Calcium Binding Protein G / analysis. Sensitivity and Specificity. Steroidogenic Factor 1 / analysis. Young Adult

  • Genetic Alliance. consumer health - Pheochromocytoma.
  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • MedlinePlus Health Information. consumer health - Pheochromocytoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20154585.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Chromogranins; 0 / NR5A1 protein, human; 0 / S100 Calcium Binding Protein G; 0 / Steroidogenic Factor 1; 57285-09-3 / Inhibins
  •  go-up   go-down


58. Spinazzi R, Rucinski M, Neri G, Malendowicz LK, Nussdorfer GG: Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells. J Clin Endocrinol Metab; 2005 Jun;90(6):3544-9
Hazardous Substances Data Bank. HYDROCORTISONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells.
  • We previously found that orexin-A, via the OX1-R, stimulates cortisol secretion from dispersed human adrenocortical cells.
  • In this study, we demonstrate that six of eight cortisol-secreting adenomas expressed preproorexin mRNA, and seven of 10 adenomas contained measurable amounts of orexin-A but not orexin-B.
  • Normal adrenal cortexes neither expressed preproorexin nor contained orexins.
  • All adenomas expressed OX1-R and OX2-R mRNAs, and real-time PCR showed that the expression of both receptors was up-regulated in adenomas, compared with normal adrenal cortex.
  • Orexin-A concentration-dependently raised basal cortisol secretion from freshly dispersed normal and adenomatous cells, minimal and maximal effective concentrations being 10(-10) and 10(-8) m, and the peptide efficacy (percent increase elicited by 10(-8) m orexin-A) was significantly higher in adenomas than in the normal adrenal cortex.
  • Collectively, our findings allow us to conclude that the orexin system is overexpressed in cortisol-secreting adenomas and suggest that orexin-A may act as an autocrine-paracrine regulator of the secretory activity and growth of some of these adrenal tumors.
  • [MeSH-major] Adrenal Cortex Neoplasms / genetics. Adrenocortical Adenoma / genetics. Hydrocortisone / secretion. Receptors, Neuropeptide / genetics

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15797953.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Complementary; 0 / HCRT protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / Neuropeptides; 0 / Orexin Receptors; 0 / Orexins; 0 / RNA, Messenger; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Neuropeptide; WI4X0X7BPJ / Hydrocortisone
  •  go-up   go-down


59. Blanco C, Maqueda E, Rubio JA, Rodriguez A: Cushing's syndrome during pregnancy secondary to adrenal adenoma: metyrapone treatment and laparoscopic adrenalectomy. J Endocrinol Invest; 2006 Feb;29(2):164-7
Hazardous Substances Data Bank. METYRAPONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cushing's syndrome during pregnancy secondary to adrenal adenoma: metyrapone treatment and laparoscopic adrenalectomy.
  • Cushing's syndrome during pregnancy is a rare and difficult to diagnose disorder.
  • We describe the case of a 30-yr-old woman presenting with symptoms and signs of mild hypercortisolism, in which ACTH-independent Cushing's syndrome was diagnosed.
  • An abdominal computed tomography scan confirmed a left adrenal mass.
  • While diagnosis work-up was still in progress, the patient became pregnant and wanted to carry her pregnancy to full-term.
  • Pathologic examination of the gland showed a benign adrenocortical adenoma.
  • The patient developed secondary adrenal insufficiency and was discharged on 20 mg hydrocortisone daily dose.
  • No apparent metyrapone-induced teratogenic effects were observed and there was no clinical or biochemical suppression of adrenocortical function.
  • In conclusion, in adrenal Cushing's syndrome during pregnancy, medical treatment with metyrapone as soon as the diagnosis is made, in combination with laparoscopic surgery during the second trimester, are useful in preventing complications secondary to hypercortisolism and safe both for the mother and infant.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Adrenalectomy. Cushing Syndrome / therapy. Metyrapone / therapeutic use. Pregnancy Complications / therapy


60. Browning L, Bailey D, Parker A: D2-40 is a sensitive and specific marker in differentiating primary adrenal cortical tumours from both metastatic clear cell renal cell carcinoma and phaeochromocytoma. J Clin Pathol; 2008 Mar;61(3):293-6
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] D2-40 is a sensitive and specific marker in differentiating primary adrenal cortical tumours from both metastatic clear cell renal cell carcinoma and phaeochromocytoma.
  • BACKGROUND: The morphological similarities between the cells of clear cell renal cell carcinoma (CCRCC) and those of the adrenal cortex impose diagnostic difficulties, for example in the context of a solitary nodule in the adrenal gland in a patient with renal cell carcinoma (RCC).
  • D2-40, an antibody commonly used to highlight lymphatic endothelial cells, is consistently positive in the normal adrenal cortex.
  • AIMS: To investigate the utility of D2-40 in distinguishing neoplastic and non-neoplastic adrenal cortical cells from those of CCRCC, and from phaeochromocytoma.
  • METHODS: D2-40 antibody was applied to tissue sections from 10 normal adrenal glands, 15 renal carcinomas (13 clear cell, 2 papillary variants), 1 metastatic CCRCC in the adrenal gland, 6 adrenal cortical hyperplasias, 5 adrenal cortical adenomas, 3 adrenal cortical carcinomas, and 4 phaeochromocytomas.
  • RESULTS: D2-40 was strongly and diffusely positive in the cells of the neoplastic and non-neoplastic adrenal cortex, but negative in the cells of the CCRCC, both primary and metastatic, in 100% of the cases.
  • The cells of the adrenal medulla, and those of the phaeochromocytomas, were negative for D2-40.
  • CONCLUSIONS: D2-40 may be a useful marker for distinguishing primary adrenal cortical neoplasms from both metastatic CCRCC and phaeochromocytoma.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Antibodies, Monoclonal / analysis. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / secondary. Pheochromocytoma / diagnosis
  • [MeSH-minor] Adenoma / diagnosis. Adrenal Glands / immunology. Antibodies, Monoclonal, Murine-Derived. Carcinoma / diagnosis. Cytoplasm / immunology. Diagnosis, Differential. Humans. Immunohistochemistry


61. Rohana AG, Ming W, Norlela S, Norazmi MK: Functioning adrenal adenoma in association with congenital adrenal hyperplasia. Med J Malaysia; 2007 Jun;62(2):158-9
MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functioning adrenal adenoma in association with congenital adrenal hyperplasia.
  • We report a case of a young hypertensive male who was first seen in 1998 with a right thalamic haemorrhage and uncontrolled hypertension.
  • CT abdomen showed a right adrenal tumour and a hyperplastic left adrenal gland.
  • Laparoscopic adrenalectomy performed followed by histopathological examination confirmed the diagnosis of adrenal adenoma.
  • This was confirmed to be due to partial or late-onset congenital adrenal hyperplasia (CAH).
  • We discuss the association of partial CAH and adrenal tumours and the unmasking of the mineralocorticoid deficiency following adrenalectomy.
  • [MeSH-major] Adenoma / etiology. Adrenal Gland Neoplasms / etiology. Adrenal Hyperplasia, Congenital / complications


62. Pittavini L, De Gaetano A, Solano G, Losito A: Resistant arterial hypertension: association with syncronous kidney cancer and adrenal adenoma. J Nephrol; 2010 Sep-Oct;23(5):614-6
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resistant arterial hypertension: association with syncronous kidney cancer and adrenal adenoma.
  • The coexistence of renal cancer and adrenal adenoma is rare.
  • We report the case of a 60-year-old patient with synchronous hypernephroma and adrenal adenoma.
  • This suggests that the coexistence of kidney cancer and adrenal adenoma may be a curable cause of resistant hypertension.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Carcinoma, Renal Cell / complications. Hypertension / etiology. Kidney Neoplasms / complications. Neoplasms, Multiple Primary / complications


63. Ors F, Lev-Toaff A, O'Kane P, Qazi N, Bergin D: Paraovarian adrenal rest with MRI features characteristic of an adrenal adenoma. Br J Radiol; 2007 Sep;80(957):e205-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraovarian adrenal rest with MRI features characteristic of an adrenal adenoma.
  • We report MR and sonographic imaging features of an incidentally detected paraovarian adrenal rest in a 44-year-old woman who was being evaluated for menorrhagia.
  • This is the first report of chemical shift imaging identifying the presence of lipid within an adrenal rest as well as rapid washout of contrast.
  • Both of these MR characteristics are typically seen with an adrenal adenoma.
  • [MeSH-major] Adrenal Rest Tumor / diagnosis. Fallopian Tube Neoplasms / diagnosis
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / ultrasonography. Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / ultrasonography. Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17928489.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


64. Kimura M, Irie A, Minei S, Ishii J, Okawa A, Takashima R, Kadowaki K, Morinaga S, Baba S: [A case of adrenocortical adenoma coexisting with gastrointestinal stromal tumor]. Hinyokika Kiyo; 2007 Aug;53(8):551-5
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of adrenocortical adenoma coexisting with gastrointestinal stromal tumor].
  • A 48-year-old man was referred to our institute for the evaluation of a concomitant gastric submucosal tumor and right adrenal tumor, incidentally found by ultrasound examination.
  • Computed tomography showed a mass with a diameter of 6 cm adjacent to the stomach and the right adrenal tumor with a diameter of 3 cm.
  • By magnetic resonance imaging, the intensity of the right adrenal tumor was equivalent to the liver in both T1 and T2 weighted images.
  • An adosterol scintigram showed slight accumulation at the region of adrenal tumor.
  • Pathological diagnosis of the adrenal tumor was a cortical adenoma, and that of the gastric submucosal tumor was gastrointestinal stromal tumor (GIST).
  • The gastric tumor was immunohistochemically stained positive with the C-kit and CD34 and negative for s-100 protein and desmin.
  • Histopathological diagnosis was coincident with gastric GIST and right adrenocortical adenoma, and the GIST was diagnosed as a high risk tumor because its diameter was over 5 cm.
  • [MeSH-major] Adrenal Cortex Neoplasms / surgery. Adrenocortical Adenoma / surgery. Gastrointestinal Stromal Tumors / surgery. Laparoscopy. Stomach Neoplasms / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17874546.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


65. Terzolo M, Bovio S, Pia A, Reimondo G, Angeli A: Management of adrenal incidentaloma. Best Pract Res Clin Endocrinol Metab; 2009 Apr;23(2):233-43
MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of adrenal incidentaloma.
  • Clinically inapparent adrenal masses, or adrenal incidentalomas, are discovered inadvertently in the course of work-up or treatment of unrelated disorders.
  • Cortical adenoma is the most frequent tumour detected incidentally, but adrenocortical cancer, phaeochromocytoma and metastasis are not rare.
  • Two critical questions should be answered before trying to outline the management of adrenal incidentaloma:.
  • (1) identify either primary (adrenocortical cancer) or secondary (adrenal metastasis) malignancy;.
  • Radiological evaluation is the key to the differential diagnosis of benign and malignant tumours.
  • Endocrine testing is necessary to exclude phaeochromocytoma in all patients with an adrenal incidentaloma because this tumour may remain undiagnosed after imaging studies.
  • The management of clinically inapparent adrenal adenomas may vary depending whether or not they are functioning.
  • It is reasonable to screen for primary aldosteronism all hypertensive patients and recommend adrenalectomy when an aldosterone-producing adenoma is confirmed.
  • A subset of adenomas secretes cortisol autonomously and may lead to mild hypercortisolism, a condition defined as subclinical Cushing's syndrome.
  • Also the management of this condition is largely empirical, and data are insufficient to indicate the superiority of a surgical or non-surgical approach to managing patients with subclinical Cushing's syndrome.
  • [MeSH-major] Adrenal Gland Neoplasms / therapy
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / drug therapy. Adenoma / therapy. Animals. Humans. Pheochromocytoma / diagnosis. Pheochromocytoma / therapy

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19500766.001).
  • [ISSN] 1878-1594
  • [Journal-full-title] Best practice & research. Clinical endocrinology & metabolism
  • [ISO-abbreviation] Best Pract. Res. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 46
  •  go-up   go-down


66. Mahe E, El-Shinnawy I: A "tumour trifecta:" myelolipomata arising within an adrenocortical adenoma ipsilateral to a synchronous clear cell renal cell carcinoma. Malays J Pathol; 2010 Dec;32(2):123-8
MedlinePlus Health Information. consumer health - Kidney Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A "tumour trifecta:" myelolipomata arising within an adrenocortical adenoma ipsilateral to a synchronous clear cell renal cell carcinoma.
  • We present an intriguing case of adrenal myelolipomata occurring within an adrenocortical adenoma in concert with an ipsilateral clear cell renal cell carcinoma.
  • Computed tomography indicated a 2.5 cm right renal mass as well as a 5 cm right adrenal mass.
  • Histology of the renal mass was consistent with conventional clear cell renal cell carcinoma, Fuhrman grade III.
  • There was no extra-renal extension or lymphovascular invasion.
  • The adrenal mass was a cortical adenoma with solid and nested patterns, with discrete zones consisting of erythroid, myeloid and megakaryocytic cells intermixed with mature adipocytes.
  • We also present a relevant review of the literature pertaining to adrenal lesions.
  • In particular, we emphasize the epidemiological, histological and immunohistochemical features that are helpful in determining the origin and malignant potential of adrenal lesions.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Myelolipoma / pathology. Neoplasms, Multiple Primary / pathology


67. Tadjine M, Lampron A, Ouadi L, Bourdeau I: Frequent mutations of beta-catenin gene in sporadic secreting adrenocortical adenomas. Clin Endocrinol (Oxf); 2008 Feb;68(2):264-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Frequent mutations of beta-catenin gene in sporadic secreting adrenocortical adenomas.
  • OBJECTIVE: Molecular alterations remain largely unknown in most sporadic adrenocortical tumours and hyperplasias.
  • In our previous work, we demonstrated the differential expression of several Wnt/beta-catenin signalling-related genes implicated in ACTH-independent macronodular adrenal hyperplasias (AIMAH).
  • To better understand the role of Wnt/beta-catenin signalling in adrenocortical tumours, we performed mutational analysis of the beta-catenin gene.
  • METHODS: We studied 53 human adrenocortical samples (33 adenomas, 4 carcinomas, 13 AIMAH, 3 ACTH-dependent adrenal hyperplasias) and the human adrenocortical cancer cell line NCI-H295R.
  • RESULTS: No mutations were detected in adrenocortical carcinomas, AIMAH and ACTH-dependent hyperplasias.
  • Genetic alterations were found in 5 (15%) out of 33 adenomas: three cortisol-secreting adenomas, one aldosterone-secreting adenoma and one nonfunctional adenoma.
  • In addition, cytoplasmic and/or nuclear accumulation of beta-catenin was observed in mutated adenomas by immunohistochemistry.
  • CONCLUSIONS: Activating mutations of exon 3 of the beta-catenin gene are frequent in adrenocortical adenomas, and further characterization of the Wnt/beta-catenin signalling pathway should lead to a better understanding of adrenal tumourigenesis.
  • [MeSH-major] Adrenocortical Adenoma / genetics. Adrenocortical Adenoma / metabolism. beta Catenin / genetics. beta Catenin / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17854394.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / beta Catenin
  •  go-up   go-down


68. Kamenicky P, Houdoin L, Ferlicot S, Salenave S, Brailly S, Droupy S, Meduri G, Sasano H, Suzuki T, Young J, Chanson P: Benign cortisol-secreting adrenocortical adenomas produce small amounts of androgens. Clin Endocrinol (Oxf); 2007 Jun;66(6):778-88
Hazardous Substances Data Bank. Corticotropin .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign cortisol-secreting adrenocortical adenomas produce small amounts of androgens.
  • BACKGROUND: Serum androgen levels are below normal in patients with benign cortisol-secreting adrenocortical adenomas, owing to ACTH suppression.
  • The objective of the study was to analyse the androgen-producing ability of cortisol-secreting adrenocortical adenomas.
  • METHODS: Dehydroepiandrosterone sulfate (DHEAS), Delta4androstenedione and testosterone concentrations were measured before and after adrenalectomy and then at 6-month intervals in 20 women (eight cortisol-secreting adrenocortical adenomas, six subclinical cortisol-secreting adrenocortical adenomas, and six nonfunctional adenomas).
  • RESULTS: Before adrenalectomy, serum androgen concentrations were measurable in all women with clinically apparent and subclinical cortisol-secreting adrenocortical adenomas.
  • Postoperatively, during adrenocortical insufficiency, DHEAS, Delta4androstenedione and testosterone concentrations fell to near the detection limit in all patients with cortisol-secreting adrenocortical adenomas (P = 0.008 for each marker) and showed a similar tendency to fall in all patients with subclinical cortisol-secreting adrenocortical adenomas.
  • Pre- and post-treatment androgen concentrations did not differ in patients with nonfunctional adenomas.
  • The intensity of CYP17 and SULT2A1 expression was stronger in cortisol-secreting adenomas than in their adjacent normal adrenal tissue.
  • CONCLUSION: Both clinically apparent and subclinical cortisol-secreting adrenocortical adenomas appear to show moderate autonomous androgen production.
  • Thus, weak androgen secretion in patients with adrenocortical tumours should not necessarily be considered as a sign of malignancy.
  • [MeSH-major] Adenoma / secretion. Adrenal Cortex Neoplasms / secretion. Androgens / secretion. Hydrocortisone / secretion

  • Hazardous Substances Data Bank. HYDROCORTISONE .
  • Hazardous Substances Data Bank. TESTOSTERONE .
  • Hazardous Substances Data Bank. ANDROSTENEDIONE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17408424.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Androgens; 0 / Estrogens; 0 / Gonadotropins, Pituitary; 3XMK78S47O / Testosterone; 409J2J96VR / Androstenedione; 57B09Q7FJR / Dehydroepiandrosterone Sulfate; 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone
  •  go-up   go-down


69. Raparia K, Ayala AG, Sienko A, Zhai QJ, Ro JY: Myxoid adrenal cortical neoplasms. Ann Diagn Pathol; 2008 Oct;12(5):344-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myxoid adrenal cortical neoplasms.
  • Myxoid adrenal cortical neoplasms are rare, and to our knowledge, only about 23 cases have been reported in the literature, including 13 carcinomas and 10 adenomas.
  • We recently experienced 4 cases of myxoid adrenal cortical neoplasms (3 benign and 1 borderline malignancy) and studied the clinical, histopathological, and immunohistochemical features of these neoplasms.
  • Three tumors were benign and 1 was of borderline morphology with mitoses of 3/10 high-power fields and mild to moderate nuclear pleomorphism.
  • Myxoid changes in adrenal cortical neoplasms are rare but can be seen in both an adenoma and a tumor of uncertain malignant potential.
  • The usual clinical and histological features can be applied to classify the lesions as benign, borderline tumor, or malignant.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Adrenocortical Carcinoma / pathology. Mucins / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18774497.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins; 0 / Synaptophysin; 0 / Vimentin; 57285-09-3 / Inhibins
  •  go-up   go-down


70. Yan QZ, Li HZ, Pan DL: [Causes of delaying diagnosis of primary hyperaldosteronism with adrenal adenoma and strategy therefore]. Zhonghua Yi Xue Za Zhi; 2006 Nov 14;86(42):3002-4
Genetic Alliance. consumer health - Hyperaldosteronism.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Causes of delaying diagnosis of primary hyperaldosteronism with adrenal adenoma and strategy therefore].
  • OBJECTIVE: To analyze the causes of delaying diagnosis of primary hyperaldosteronism with adrenal adenoma and discuss corrective strategies.
  • METHODS: The clinical data of 267 patients of primary hyperaldosteronism with adrenal adenoma confirmed by operation 1995 - 2005 were analyzed.
  • RESULTS: Confirmed diagnosis was made after a duration of (92 +/- 64) months (3 - 40 years) after the first visit.
  • 95.9% of the patients were diagnosed as with primary hypertension at the first visit without receiving relevant imaging examination of adrenal and endocrine examination.
  • Adrenal adenoma was discovered by computed tomography with thin coat screening in 267 patients and by ultrasonography in 151 patients.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Hyperaldosteronism / diagnosis
  • [MeSH-minor] Adult. Aged. Aldosterone / blood. Biomarkers, Tumor / blood. Chymosin / blood. Early Diagnosis. Female. Humans. Hypertension / diagnosis. Hypokalemia / diagnosis. Male. Mass Screening / methods. Middle Aged. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity. Time Factors. Tomography, X-Ray Computed. Ultrasonography

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17288816.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 4964P6T9RB / Aldosterone; EC 3.4.23.4 / Chymosin
  •  go-up   go-down


71. Boyle B, Butz H, Liko I, Zalatnai A, Toth M, Feldman K, Horanyi J, Igaz P, Racz K, Patocs A: Expression of glucocorticoid receptor isoforms in human adrenocortical adenomas. Steroids; 2010 Oct;75(10):695-700

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of glucocorticoid receptor isoforms in human adrenocortical adenomas.
  • INTRODUCTION: Glucocorticoid receptor (GR) is expressed in the normal human adrenal gland, however, no study has been performed to evaluate the separate expression of alpha- and beta-isoforms (GRalpha and GRbeta) in normal human adrenals and in adrenocortical adenomas.
  • EXPERIMENTAL: GRalpha and GRbeta mRNA expression was examined by quantitative real-time PCR in 31 adrenal tissues including 19 non-functioning adenomas (NFA), 6 cortisol-producing adenomas (CPA) and 6 normal adrenocortical tissues.
  • In addition, the presence and cellular localization of GRalpha and GRbeta proteins in adrenal tissues were studied by immunohistochemistry.
  • RESULTS: Compared to normal adrenocortical tissues, both GRalpha and GRbeta mRNAs were significantly increased in CPA but not in NFA.
  • Using anti-GRalpha antibody a strong nuclear staining was observed in NFA and CPA, and a less remarkable immunoreactivity was detected in some nuclei of normal adrenocortical cells.
  • GRbeta immunostaining was absent in normal adrenal tissues and NFA, while a strong cytoplasmic and nuclear immunoreaction was found in CPA.
  • CONCLUSIONS: Altered expression of GRalpha and GRbeta in CPA raises their possible role in the pathophysiology of these adrenal tumors, although further studies are needed to elucidate the potential significance of these findings.
  • [MeSH-major] Adrenocortical Adenoma / metabolism. Protein Isoforms / metabolism. Receptors, Glucocorticoid / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20438742.001).
  • [ISSN] 1878-5867
  • [Journal-full-title] Steroids
  • [ISO-abbreviation] Steroids
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Receptors, Glucocorticoid
  •  go-up   go-down


72. Mishra AK, Agarwal A, George RK, Gupta S, Mishra SK: Laparoscopic adrenalectomy for Conn's syndrome: report of the initial six cases. Int Surg; 2009 Jan-Feb;94(1):31-4
Genetic Alliance. consumer health - Conn's Syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic adrenalectomy for Conn's syndrome: report of the initial six cases.
  • We report our experience with the initial six cases of transperitoneal laparoscopic adrenalectomy for primary hyperaldosteronism (Conn's syndrome).
  • From 1997 to 2002, 6 patients with primary hyperaldosteronism (Conn's syndrome) were referred to the Department of Endocrine Surgery and underwent laparoscopic adrenalectomy through the transperitoneal approach.
  • In all patients, the adrenal gland and the adenoma were successfully removed laparoscopically, and all patients were normokalemic and normotensive in the first follow-up after 6 months.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20099423.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


73. Slater EP, Diehl SM, Langer P, Samans B, Ramaswamy A, Zielke A, Bartsch DK: Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors. Eur J Endocrinol; 2006 Apr;154(4):587-98
Hazardous Substances Data Bank. HYDROCORTISONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors.
  • OBJECTIVES: Adrenocortical carcinoma (ACC) is a rare malignant neoplasm with extremely poor prognosis.
  • The molecular mechanisms of adrenocortical tumorigenesis are still not well understood.
  • The comparative analysis by cDNA microarrays of gene-expression patterns of benign and malignant adrenocortical tumors allows us to identify new tumor-suppressor genes and proto-oncogenes underlying adrenocortical tumorigenesis.
  • DESIGN AND METHODS: Total RNA from fresh-frozen tissue of 10 ACC and 10 benign adrenocortical adenomas was isolated after histologic confirmation of neoplastic cellularity of at least 85%.
  • The reference consisted of pooled RNA of 10 normal adrenal cortex samples.
  • RESULTS: The comparative analysis of gene expression revealed many genes with more than fourfold expression difference between ACC and normal tissue (42 genes), cortical adenoma and normal tissue (11 genes), and ACC and cortical adenoma (21 genes) respectively.
  • As confirmed by real-time PCR, the IGF2 gene was significantly upregulated in ACCs versus cortical adenomas and normal cortical tissue.
  • Genes that were downregulated in adrenocortical tumors included chromogranin B and early growth response factor 1.
  • CONCLUSIONS: Comprehensive expression profiling of adrenocortical tumors by the cDNA microarray technique is a very powerful tool to elucidate the molecular steps associated with the tumorigenesis of these ill-defined neoplasms.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16556722.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; 4964P6T9RB / Aldosterone; WI4X0X7BPJ / Hydrocortisone
  •  go-up   go-down


74. Ammoury RF, Heptulla RA, Tatevian N, Elenberg E: Laparoscopic adrenalectomy of an adrenal adenoma with myelolipoma relieves severe hypertension in a 16-year-old patient. Pediatr Nephrol; 2006 Mar;21(3):433-6
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic adrenalectomy of an adrenal adenoma with myelolipoma relieves severe hypertension in a 16-year-old patient.
  • Adrenal adenoma with myelolipoma is extremely rare in pediatrics.
  • A 16-year-old patient was diagnosed with severe hypertension associated with a right adrenal mass.
  • MRI of the abdomen showed a heterogeneous adrenal mass 4.2x3.3 cm.
  • Laparoscopic resection of the mass was done, and the pathology revealed an adrenal adenoma with myelolipoma.
  • This is a case in which an adrenal adenoma with myelolipoma, a benign and usually asymptomatic tumor, presented as severe hypertension resolving with surgical resection of the tumor.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy. Adrenocortical Adenoma / surgery. Hypertension / etiology. Laparoscopy. Myelolipoma / surgery. Neoplasms, Multiple Primary / surgery

  • Genetic Alliance. consumer health - Adrenal Hypertension.
  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • MedlinePlus Health Information. consumer health - High Blood Pressure.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Urol. 1995 Jun;153(6):1791-3 [7752318.001]
  • [Cites] Pediatr Hematol Oncol. 1998 Nov-Dec;15(6):527-32 [9842646.001]
  • [Cites] J Urol. 1997 Apr;157(4):1213-6 [9120904.001]
  • [Cites] J Pediatr Surg. 1994 Oct;29(10):1388-91 [7807333.001]
  • [Cites] Endocrinol Metab Clin North Am. 1997 Dec;26(4):741-62 [9429858.001]
  • [Cites] Abdom Imaging. 1994 Mar-Apr;19(2):165-7 [8199553.001]
  • [Cites] J Urol. 1992 Apr;147(4):1089-90 [1552592.001]
  • [Cites] Acta Cytol. 1991 May-Jun;35(3):353-6 [2042437.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Mar;87(3):998-1003 [11889151.001]
  • [Cites] Radiographics. 1999 May-Jun;19(3):569-81 [10336189.001]
  • [Cites] Am J Clin Pathol. 1986 Oct;86(4):541-5 [3766467.001]
  • (PMID = 16382320.001).
  • [ISSN] 0931-041X
  • [Journal-full-title] Pediatric nephrology (Berlin, Germany)
  • [ISO-abbreviation] Pediatr. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


75. Yoon JH, Kim SH, Kim MA, Han JK, Choi BI: MDCT and Gd-EOB-DTPA enhanced MRI findings of adrenal adenoma arising from an ectopic adrenal gland within the liver: radiologic-pathologic correlation. Korean J Radiol; 2010 Jan-Feb;11(1):126-30
Hazardous Substances Data Bank. GADOPENTETATE DIMEGLUMINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MDCT and Gd-EOB-DTPA enhanced MRI findings of adrenal adenoma arising from an ectopic adrenal gland within the liver: radiologic-pathologic correlation.
  • We report a case of an adenoma arising from an ectopic adrenal gland mimicking a hepatocellular carcinoma in a heavy alcohol abuser.
  • A tumorectomy was performed and adrenal adenoma from an ectopic adrenal gland within the liver was confirmed.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Choristoma / diagnosis. Contrast Media. Gadolinium DTPA. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Adrenal Glands. Carcinoma, Hepatocellular / diagnosis. Diagnosis, Differential. Humans. Male. Middle Aged

  • MedlinePlus Health Information. consumer health - CT Scans.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • MedlinePlus Health Information. consumer health - MRI Scans.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Clin Endocrinol Metab. 1998 Nov;83(11):3786-9 [9814447.001]
  • [Cites] Hepatology. 2005 Nov;42(5):1208-36 [16250051.001]
  • [Cites] AJR Am J Roentgenol. 2007 Mar;188(3):W246-8 [17312030.001]
  • [Cites] Eur Urol. 2009 Dec;56(6):1082-5 [19447543.001]
  • [Cites] J Clin Endocrinol Metab. 1992 Dec;75(6):1522-5 [1464658.001]
  • [Cites] Radiology. 2002 Mar;222(3):629-33 [11867777.001]
  • [Cites] Zentralbl Pathol. 1991;137(2):117-22 [1911725.001]
  • [Cites] J Urol. 1976 Mar;115(3):323-5 [1255896.001]
  • [Cites] J Urol. 1979 Mar;121(3):353-4 [430634.001]
  • [Cites] Clin Endocrinol (Oxf). 1979 May;10(5):493-7 [476979.001]
  • [Cites] Histopathology. 1980 Nov;4(6):669-72 [7439895.001]
  • [Cites] Am J Gastroenterol. 1986 Oct;81(10):999-1001 [3766504.001]
  • [Cites] J Pathol. 1974 Aug;113(4):231-3 [4427201.001]
  • (PMID = 20046505.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media; 0 / gadolinium ethoxybenzyl DTPA; K2I13DR72L / Gadolinium DTPA
  • [Other-IDs] NLM/ PMC2799643
  • [Keywords] NOTNLM ; Adrenal adenoma / Ectopic adrenal gland / Liver / Magnetic resonance (MR) / Multi-detector computed tomography (MDCT)
  •  go-up   go-down


76. Hosogi H, Nagayama S, Kanamoto N, Yoshizawa A, Suzuki T, Nakao K, Sakai Y: Biallelic APC inactivation was responsible for functional adrenocortical adenoma in familial adenomatous polyposis with novel germline mutation of the APC gene: report of a case. Jpn J Clin Oncol; 2009 Dec;39(12):837-46
Genetic Alliance. consumer health - Familial Polyposis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biallelic APC inactivation was responsible for functional adrenocortical adenoma in familial adenomatous polyposis with novel germline mutation of the APC gene: report of a case.
  • Familial adenomatous polyposis (FAP) patients develop various extracolonic lesions, among which functional adrenocortical neoplasms are infrequent.
  • Furthermore, bilateral adrenocortical adenomas were detected, and functional analyses showed a hormonal secretion pattern consistent with Cushing's syndrome.
  • At 10 months post-operative with no detectable metastatic lesions, the residual colorectum and the larger, left adrenal gland were resected, and the hormonal hypersecretion was normalized.
  • Biallelic APC inactivation due to loss of the normal allele was evident in the adrenocortical adenoma.
  • Immunostaining for beta-catenin revealed diffuse cytoplasmic expression in resected tissues including adrenocortical adenoma.
  • Biallelic APC inactivation may play a role in developing cortisol-secreting adrenocortical adenoma in FAP patients.
  • [MeSH-major] Adenomatous Polyposis Coli / metabolism. Adenomatous Polyposis Coli Protein / genetics. Adrenocortical Adenoma / metabolism. Genes, APC / physiology

  • Genetic Alliance. consumer health - Familial Adenomatous Polyposis (FAP).
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19684041.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein
  •  go-up   go-down


77. Abdullah N, Khawaja K, Hale J, Barrett AM, Cheetham TD: Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. J Pediatr Endocrinol Metab; 2005 Feb;18(2):215-9
Hazardous Substances Data Bank. POTASSIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy.
  • Investigations revealed primary hyperaldosteronism secondary to an adrenal adenoma (Conn's syndrome).
  • The hypertension resolved following excision of the adrenal tumour.
  • Normokalaemia with potassium >4.0 mmol/l is very unusual in patients with Conn's syndrome and has not been described in childhood before.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Adrenal Gland Neoplasms / diagnosis. Adrenocortical Adenoma / complications. Adrenocortical Adenoma / diagnosis. Hyperaldosteronism / etiology. Hypertension / etiology. Potassium / blood


78. Hunger-Battefeld W, Gajda M, Hansch A, Mandecka A, Müller UA, Wolf G: [Diagnostic pitfalls with Cushing's syndrome]. Internist (Berl); 2010 Mar;51 Suppl 1:293-302
Hazardous Substances Data Bank. HYDROCORTISONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adrenal cortical carcinoma is a rare diagnosis and may present with hormone secretion.
  • A histological differentiation between an adrenal cortical adenoma and carcinoma can be very difficult.
  • However, a fast diagnosis including staging and complete surgical resection is pivotal for the prognosis of an adrenal cortical carcinoma.
  • Metastasing adrenal cortical carcinoma should be treated with a mitotane based chemotherapy, and inclusion in the "firm-act study" is highly recommended.
  • The present case report demonstrates the diagnostic pitfalls in a female patients with Cushing's syndrome who suffered from metastasing adrenal cortical carcinoma.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Carcinoma, Renal Cell / diagnosis. Cushing Syndrome / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Adrenal Cortex / pathology. Adrenalectomy. Circadian Rhythm / physiology. Diabetes Mellitus, Type 2 / etiology. Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Hydrocortisone / blood. Hypertension / etiology. Kidney / pathology. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Obesity, Morbid / etiology. Weight Gain

  • Genetic Alliance. consumer health - Cushing's Syndrome.
  • MedlinePlus Health Information. consumer health - Cushing's Syndrome.
  • MedlinePlus Health Information. consumer health - Kidney Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Lab Invest. 1995 Apr;72(4):424-31 [7723281.001]
  • [Cites] World J Surg. 2008 Aug;32(8):1802-8 [18425548.001]
  • [Cites] J Endocrinol Invest. 2007 Sep;30(8):647-52 [17923795.001]
  • [Cites] Front Horm Res. 2004;32:110-26 [15281342.001]
  • [Cites] Surgery. 1992 Dec;112(6):963-70; discussion 970-1 [1455321.001]
  • [Cites] Cancer. 1995 Feb 1;75(3):860-4 [7828138.001]
  • [Cites] Am J Surg Pathol. 2002 Dec;26(12):1612-9 [12459628.001]
  • [Cites] World J Surg. 2001 Jul;25(7):891-7 [11572030.001]
  • [Cites] Presse Med. 1995 Nov 11;24(34):1605-7 [8545366.001]
  • [Cites] Ann Surg Oncol. 1999 Dec;6(8):719-26 [10622498.001]
  • [Cites] J Clin Endocrinol Metab. 2006 Jun;91(6):2027-37 [16551738.001]
  • [Cites] Exp Clin Endocrinol Diabetes. 2008 Apr;116(4):246-51 [18393131.001]
  • [Cites] Surgery. 2006 Dec;140(6):914-20; discussion 919-20 [17188138.001]
  • [Cites] Virchows Arch A Pathol Anat Histopathol. 1992;420(1):65-70 [1539453.001]
  • [Cites] Endocr Pathol. 2005 Spring;16(1):13-22 [16000842.001]
  • [Cites] APMIS. 1998 Aug;106(8):807-17 [9744767.001]
  • [Cites] Rev Hosp Clin Fac Med Sao Paulo. 2002 Nov-Dec;57(6):251-6 [12612756.001]
  • [Cites] Horm Metab Res. 1998 Jun-Jul;30(6-7):436-9 [9694576.001]
  • [Cites] Endocr J. 2008 Mar;55(1):49-55 [18187873.001]
  • [Cites] Surgery. 1996 Feb;119(2):161-70 [8571201.001]
  • [Cites] Lab Invest. 1992 Feb;66(2):169-74 [1735954.001]
  • [Cites] Eur J Clin Invest. 2000 Dec;30 Suppl 3:58-62 [11281370.001]
  • [Cites] J Clin Endocrinol Metab. 2007 Jan;92(1):148-54 [17062775.001]
  • [Cites] J Clin Oncol. 2002 Feb 15;20(4):941-50 [11844815.001]
  • [Cites] Cancer. 1985 Feb 15;55(4):766-73 [3967172.001]
  • [Cites] Am J Surg Pathol. 1984 Mar;8(3):163-9 [6703192.001]
  • (PMID = 20012255.001).
  • [ISSN] 1432-1289
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] WI4X0X7BPJ / Hydrocortisone
  •  go-up   go-down


79. Qiao ZW, Xia CM, Zhu YB, Shi WP, Miao F: First-pass perfusion computed tomography: initial experience in differentiating adrenal adenoma from metastasis. Eur J Radiol; 2010 Mar;73(3):657-63
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] First-pass perfusion computed tomography: initial experience in differentiating adrenal adenoma from metastasis.
  • OBJECTIVE: To differentiate adrenal adenoma from metastasis in patients using perfusion computed tomography (PCT) imaging.
  • METHODS: Thirty-two patients with adrenal masses underwent first-pass PCT imaging.
  • Of these patients, twenty-one were diagnosed with adrenal adenoma, and the others with metastases.
  • RESULTS: The perfusion parameters such as BV, BF and PS were statistically significant different between the two groups, with adenomas showing higher mean BV (12.18 versus 3.86), BF (97.51 versus 45.99) and PS (21.73 versus 10.93) compared with metastases (p<0.05).
  • For BV, a cutoff point of 7.30 was found to have a sensitivity of 95.2% and a specificity of 100% to differentiate between adenoma and metastasis.
  • The sensitivity and specificity were 81.0 and 80.0%, respectively, for BF with a cutoff point of 71.96; and 85.7 and 86.7%, respectively, for PS with a cutoff point of 12.70 to differentiate adenoma and metastasis.
  • A comparison of MVD counts from adenomas with those from metastases showed a significant difference (p<0.05).
  • However, no significant differences were observed in the four perfusion parameters and MVD between lipid rich and lipid poor adenomas.
  • CONCLUSION: PCT may be useful for evaluating the neovascularization of adrenal masses and differentiating adenoma from metastasis on the basis of PCT parameters.
  • Adenomas show higher BV, BF and PS compared with metastases.
  • According our data, the optimal threshold BV is 7.30, resulting in a sensitivity of 95.2% and a specificity of 100% for the differentiation of adenoma from metastasis.
  • Adrenal adenomas have similar hemodynamic profiles, which are apparently independent of the lipid content of an adenoma.
  • [MeSH-major] Adrenal Gland Neoplasms / radiography. Adrenocortical Adenoma / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Contrast Media. Diagnosis, Differential. Female. Humans. Iohexol / analogs & derivatives. Male. Microcirculation. ROC Curve. Radiographic Image Interpretation, Computer-Assisted

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • MedlinePlus Health Information. consumer health - CT Scans.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19200677.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
  •  go-up   go-down


80. Ye H, Yoon GS, Epstein JI: Intrarenal ectopic adrenal tissue and renal-adrenal fusion: a report of nine cases. Mod Pathol; 2009 Feb;22(2):175-81
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrarenal ectopic adrenal tissue and renal-adrenal fusion: a report of nine cases.
  • Intrarenal ectopic adrenal tissue and renal-adrenal fusion are rare findings in the adult population.
  • We reviewed seven cases of intrarenal adrenal tissue and two cases of renal-adrenal fusion.
  • Ectopic adrenal tissue was identified at the superior pole of the kidney in all but one case, which was located in the mid-portion of the kidney.
  • Ectopic adrenal tissue varied in its growth from subcapsular lesions that were plaque-like (n=3), wedge-shaped (n=2), or spherical (n=1) to irregular nests deep in the renal parenchyma (n=1).
  • In all nine cases, the adherent and intrarenal adrenal tissue was composed of adrenal cortical tissue, with no adrenal medullary tissue present.
  • In six cases, adrenal tissue focally extended into renal parenchyma in an infiltrative manner.
  • In one case, intrarenal adrenal tissue mimicked low-grade clear cell renal cell carcinoma.
  • In another case, an adrenocortical adenoma adherent to the kidney resembled renal invasion by adrenocortical carcinoma.
  • This study summarizes key morphological features of intrarenal ectopic adrenal tissue and renal-adrenal fusion along with histological pitfalls and its differential diagnoses.
  • [MeSH-major] Adrenal Glands. Choristoma / pathology. Kidney / pathology. Kidney Diseases / pathology
  • [MeSH-minor] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Adrenocortical Carcinoma / pathology. Adult. Aged. Biopsy. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Female. Humans. Kidney Neoplasms / pathology. Male. Middle Aged

  • MedlinePlus Health Information. consumer health - Kidney Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18820668.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


81. Kaspareit J, Friderichs-Gromoll S, Buse E, Habermann G: Spontaneous neoplasms observed in cynomolgus monkeys (Macaca fascicularis) during a 15-year period. Exp Toxicol Pathol; 2007 Nov;59(3-4):163-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The great majority of neoplasms was benign (23 benign neoplasms versus 10 malignant tumors).
  • Most of the tumors (22) in the cynomolgus monkeys were seen in endocrine organs (adrenal cortical adenoma, adrenal hemangioma, C-cell carcinoma, follicular adenoma), respiratory system (nasal cavity adenoma, pulmonary squamous cell carcinoma, bronchio-alveolar carcinoma, bronchiolar papilloma, chondromatous hamartoma) and female genital system (uterine polyp, uterine adenoma, uterine leiomyoma and teratoma of the ovary).
  • [MeSH-major] Macaca fascicularis. Monkey Diseases / pathology. Neoplasms / veterinary

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17869495.001).
  • [ISSN] 0940-2993
  • [Journal-full-title] Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
  • [ISO-abbreviation] Exp. Toxicol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


82. Gianotti L, Tassone F, Pia A, Bovio S, Reimondo G, Visconti G, Terzolo M, Borretta G: May an altered hypothalamo-pituitary-adrenal axis contribute to cortical bone damage in primary hyperparathyroidism? Calcif Tissue Int; 2009 Jun;84(6):425-9
Hazardous Substances Data Bank. Corticotropin .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] May an altered hypothalamo-pituitary-adrenal axis contribute to cortical bone damage in primary hyperparathyroidism?
  • Our aim was to evaluate circulating and urinary cortisol levels and the relationships with biochemical and bone parameters in patients with PHPT at the time of diagnosis.
  • We studied 180 consecutive patients with PHPT (mean age +/- SD 60.0 +/- 13.2 years; F/M 140/40, BMI 25.8 +/- 4.8 kg/m(2)) and 56 subjects with incidentally discovered adrenal adenoma who served as controls (age 56.2 +/- 12.8 years, F/M 40/16, BMI 25.7 +/- 3.9 kg/m(2)).
  • Our findings show increased midnight cortisol levels in patients with PHPT, indicating a subtle alteration of the hypothalamo-pituitary-adrenal axis dynamics that is unrelated to the degree of disease activity; further data are needed to demonstrate the supplementary effect of this subtle alteration to bone damage in this condition.
  • [MeSH-major] Hydrocortisone / secretion. Hyperparathyroidism, Primary / metabolism. Hypothalamo-Hypophyseal System / secretion. Osteoporosis / metabolism. Pituitary-Adrenal System / secretion
  • [MeSH-minor] Adrenal Gland Neoplasms / blood. Adrenal Gland Neoplasms / metabolism. Adrenocorticotropic Hormone / blood. Aged. Female. Humans. Male. Middle Aged. Multivariate Analysis. Regression Analysis

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • MedlinePlus Health Information. consumer health - Osteoporosis.
  • Hazardous Substances Data Bank. HYDROCORTISONE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19381429.001).
  • [ISSN] 1432-0827
  • [Journal-full-title] Calcified tissue international
  • [ISO-abbreviation] Calcif. Tissue Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone
  •  go-up   go-down


83. Liu XK, Liu XJ, Dong X, Kong CZ: [Clinical research about treatment for adrenal incidentalomas]. Zhonghua Wai Ke Za Zhi; 2008 Jun 1;46(11):832-4
MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical research about treatment for adrenal incidentalomas].
  • OBJECTIVE: To explore the therapeutic methods of adrenal incidentalomas.
  • Pathological results indicated that 34 cases were pheochromocytoma, 83 adrenal cortical adenoma, 5 adrenal cortical carcinoma, 3 metastases carcinoma, and 26 other benign tumors.
  • 3 cases of metastases carcinoma died in 1.5 years, 2 cases of cortical carcinoma died in 2.0 and 2.5 years for recurrence and metastases.
  • CONCLUSIONS: Surgical operations should be performed in malignant tumors, hypersecretion tumors, deuto-clinical adrenal cortical tumors, pheochromocytoma and those whose diameters of tumors are over 3 cm.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19035218.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  •  go-up   go-down


84. Giordano TJ: Molecular pathology of adrenal cortical tumors: separating adenomas from carcinomas. Endocr Pathol; 2006;17(4):355-63
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular pathology of adrenal cortical tumors: separating adenomas from carcinomas.
  • Adrenal cortical carcinoma is a rare but interesting endocrine tumor.
  • Its diagnosis is usually straightforward using morphologic assessment and supplemental immunohistochemistry.
  • Here, the relevant molecular pathology of adrenal cortical tumors is reviewed with special reference to those methods (e.g., DNA microarrays) that hold promise for improved diagnosis and prognosis, and prediction of therapeutic response.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Adrenocortical Carcinoma / pathology
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. DNA, Neoplasm / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Oligonucleotide Array Sequence Analysis. Principal Component Analysis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17525484.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
  • [Number-of-references] 59
  •  go-up   go-down


85. Alam MM, Rahman MA, Naser MF, Hossain MS, Islam MA: Testosterone secreting adrenal adenoma in an adult female patient. Mymensingh Med J; 2010 Oct;19(4):632-5
Hazardous Substances Data Bank. TESTOSTERONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testosterone secreting adrenal adenoma in an adult female patient.
  • Adrenal tumours that secrete testosterone are extremely rare and we describe such a case in a 35 years old female with virilization.
  • She had left adrenal adenoma 7.5 X 6.4 cm in size, her ovaries were normal.
  • Histopathological examination confirmed the diagnosis of adrenal adenoma.

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20956912.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bangladesh
  • [Chemical-registry-number] 3XMK78S47O / Testosterone; 57B09Q7FJR / Dehydroepiandrosterone Sulfate
  •  go-up   go-down


86. Tissier F, Cavard C, Groussin L, Perlemoine K, Fumey G, Hagneré AM, René-Corail F, Jullian E, Gicquel C, Bertagna X, Vacher-Lavenu MC, Perret C, Bertherat J: Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors. Cancer Res; 2005 Sep 1;65(17):7622-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors.
  • Adrenocortical cancer is a rare cancer with a very poor prognosis.
  • The genetic alterations identified to date in adrenocortical tumors are limited.
  • We investigated whether Wnt pathway activation is involved in adrenocortical tumorigenesis.
  • In a series of 39 adrenocortical tumors, immunohistochemistry revealed abnormal cytoplasmic and/or nuclear accumulation of beta-catenin in 10 of 26 adrenocortical adenomas and in 11 of 13 adrenocortical carcinomas.
  • An activating somatic mutation of the beta-catenin gene was shown in 7 of 26 adrenocortical adenomas and in 4 of 13 adrenocortical carcinomas; these mutations were observed only in adrenocortical tumors with abnormal beta-catenin accumulation and most were point mutations altering the Ser45 of exon 3 (in the consensus GSK3-beta/CK1 phosphorylation site).
  • Functional studies showed that the activating Ser45 beta-catenin mutation found in the adrenocortical cancer H295R cell line leads to constitutive activation of T-cell factor-dependent transcription.
  • This is the first molecular defect to be reported with the same prevalence in both benign (27%) and malignant (31%) adrenocortical tumors. beta-Catenin mutations are also the most frequent genetic defect currently known in adrenocortical adenomas.
  • In adrenocortical adenomas, beta-catenin alterations are more frequent in nonfunctioning tumors, suggesting that beta-catenin pathway activation might be mostly involved in the development of nonsecreting adrenocortical adenomas and adrenocortical carcinomas.
  • The very frequent and substantial accumulation of beta-catenin in adrenocortical carcinomas suggests that other alterations might also be involved.
  • This finding may contribute to new therapeutic approaches targeting the Wnt pathway in malignant adrenocortical tumors, for which limited medical therapy is available.
  • [MeSH-major] Adrenal Cortex Neoplasms / genetics. Adrenocortical Carcinoma / genetics. Cytoskeletal Proteins / genetics. Intercellular Signaling Peptides and Proteins / genetics. Trans-Activators / genetics
  • [MeSH-minor] Adult. Aged. Cell Line, Tumor. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mutation. Signal Transduction. Wnt Proteins. beta Catenin

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16140927.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Trans-Activators; 0 / Wnt Proteins; 0 / beta Catenin
  •  go-up   go-down


87. Vesin C, Chabre O, Mallion JM, Chaffanjon P, Sturm N, Baguet JP: [Diagnosis and post-operative evolution of patients operated for adrenal adenoma (Conn syndrome). A 12-years retrospective study]. Arch Mal Coeur Vaiss; 2007 Feb;100(2):121-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and post-operative evolution of patients operated for adrenal adenoma (Conn syndrome). A 12-years retrospective study].
  • [Transliterated title] Diagnostic et évolution postopératoire des patients opérés d'un adénome de Conn. Etude rétrospective sur 12 ans.
  • The prevalence and characteristics of patients operated for adrenal adenoma (Conn syndrome) as well as their post-operative arterial pressure evolution are varying through literature.
  • From 1993 to 2005, 24 patients (mean age = 46 +/-11 years) presented the biological criteria of primary hyperaldosteronism and benefited from adrenalectomy with confirmation of adrenal adenoma.
  • All adenomas measured more than 10 mm in scanner imaging.
  • Post-operative spontaneous normotensive patients had, at the diagnosis of adrenal adenoma, a more recent and non-refractory hypertension, with a lower number of antihypertensive drugs, a better response to spirinolactone and higher aldosterone plasmatic levels.
  • 1) Whether 70% of patients operated for adrenal adenoma are normotensive (with or without treatement) post-operatively, only 25% are definitely cured after 4 years.
  • Factors associated to a post-operative cure highlight the interest of an ealy diagnosis.
  • 2) There is probably an underdiagnosis of adrenal adenoma (Conn syndrome) because neither adenomas with normokaliemia, nor adenomas <10 mm in scanner imaging have ever been diagnosed or at least, sent to surgery.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenal Cortex Neoplasms / surgery. Adrenocortical Adenoma / diagnosis. Adrenocortical Adenoma / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17474497.001).
  • [ISSN] 0003-9683
  • [Journal-full-title] Archives des maladies du coeur et des vaisseaux
  • [ISO-abbreviation] Arch Mal Coeur Vaiss
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  •  go-up   go-down


88. Berber E, Siperstein A: Laparoscopic radiofrequency thermal ablation of adrenal tumors: technical details. Surg Laparosc Endosc Percutan Tech; 2010 Feb;20(1):58-62
MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic radiofrequency thermal ablation of adrenal tumors: technical details.
  • BACKGROUND: Despite reports of percutaneous radiofrequency ablation (RFA), laparoscopic ablative techniques have not been described to treat adrenal tumors.
  • The aim of this study is to describe patient selection criteria and the technique for laparoscopic adrenal RFA.
  • METHODS: Four patients underwent laparoscopic RFA of adrenal tumors under general anesthesia for adrenal tumors.
  • RESULTS: Pathology included lung metastasis in 2 patients, and renal cell cancer metastasis and cortical adenoma in 1 patient each.
  • In the fourth patient with adrenocortical adenoma, ablation was carried out owing to the cardiopulmonary instability of the patient during attempted laparoscopic adrenalectomy.
  • Despite normal catecholamine levels preoperatively, 2 patients had a transient hypertensive period during the ablation possibly owing to the release of catecholamines from the normal adrenal medulla.
  • Patients were followed up for a mean 19 months.
  • CONCLUSIONS: To our knowledge, this is the first report of laparoscopic adrenal RFA.
  • Laparoscopic RFA is an option for patients with unresectable adrenal tumors owing to the extent of disease or comorbidities.
  • [MeSH-major] Adrenal Gland Neoplasms / therapy. Adrenalectomy / methods. Catheter Ablation / methods. Hot Temperature / therapeutic use. Laparoscopy
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Renal Cell / secondary. Carcinoma, Renal Cell / therapy. Fatal Outcome. Feasibility Studies. Female. Humans. Kidney Neoplasms / secondary. Kidney Neoplasms / therapy. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Male. Retrospective Studies

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20173624.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


89. McNicol AM: Assessment of malignancy in adrenal cortical tumors. Endocr Pathol; 2006;17(2):131-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of malignancy in adrenal cortical tumors.
  • The roles of the pathologist in assessing adrenal cortical tumors are, first, to differentiate adenoma from carcinoma, and, second, to assess prognosis when the diagnosis of malignancy is made.
  • [MeSH-major] Adenoma / pathology. Adrenal Cortex Neoplasms / pathology. Carcinoma / pathology. Neoplasm Invasiveness / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17159245.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 36
  •  go-up   go-down


90. Dinleyici EC, Dogruel N, Acikalin MF, Tokar B, Oztelcan B, Ilhan H: An additional child case of an aldosterone-producing adenoma with an atypical presentation of peripheral paralysis due to hypokalemia. J Endocrinol Invest; 2007 Nov;30(10):870-2
MedlinePlus Health Information. consumer health - Paralysis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An additional child case of an aldosterone-producing adenoma with an atypical presentation of peripheral paralysis due to hypokalemia.
  • Aldosterone-producing adenoma, which is characterized by hypertension, hypokalemia, and elevated aldosterone levels with suppressed plasma renin activity, is a rare condition during childhood and is also potentially curable.
  • To the best of our knowledge, nearly 25 cases of childhood aldosterone-secreting adenoma have been reported in the literature to date.
  • Here we describe a 13-yr-old girl with primary hyperaldosteronism secondary to aldosterone-secreting adenoma.
  • Abdominal ultrasonography and abdominal magnetic resonance imaging revealed left adrenal mass.
  • Laparoscopic adrenalectomy was performed and histopathological examinations showed benign adrenal adenoma.
  • This case demonstrates the importance of a systemic evaluation including blood pressure monitorization of children with hypokalemia as intermittent hypertension episodes may be seen; cases without hypertension may be misdiagnosed as rheumatological or neurological disorders such as hypokalemic periodic paralysis, as in our case.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Hyperaldosteronism / etiology. Hypokalemia / etiology. Paralysis / etiology

  • Genetic Alliance. consumer health - Hypokalemia.
  • Genetic Alliance. consumer health - paralysis.
  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18075291.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone
  •  go-up   go-down


91. Carney JA: Carney triad: a syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors. J Clin Endocrinol Metab; 2009 Oct;94(10):3656-62
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for carney triad .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carney triad: a syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors.
  • One also had an adrenal cortical adenoma and the other pulmonary chondroma.
  • Twenty percent of the patients had adrenocortical adenoma(s), and 10% had esophageal leiomyoma(s).
  • The pulmonary tumors were asymptomatic and benign.
  • CONCLUSION: The Carney triad is a chronic, persistent, indolent but sometimes fatal disorder of unknown etiology.
  • [MeSH-major] Adenoma. Adrenal Cortex Neoplasms. Chondroma. Esophageal Neoplasms. Leiomyoma. Lung Neoplasms. Multiple Endocrine Neoplasia. Neoplastic Syndromes, Hereditary / pathology. Paraganglioma
  • [MeSH-minor] Adolescent. Carotid Body Tumor / pathology. Chronic Disease. Female. Follow-Up Studies. Gastrointestinal Stromal Tumors / pathology. Humans. Male. Pheochromocytoma / secondary

  • MedlinePlus Health Information. consumer health - Esophageal Cancer.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19723753.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
  •  go-up   go-down


92. Adissu HA, Hayes G, Wood GA, Caswell JL: Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog. Vet Pathol; 2010 Mar;47(2):354-7
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog.
  • The pathological evaluation revealed a left atrial ossifying myxosarcoma, bilateral adrenocortical adenomas, multifocal pituitary hyperplasia with expression of adrenocorticotrophic hormone, and multiple pituitary Rathke's cleft cysts.
  • [MeSH-major] Adrenal Cortex Neoplasms / veterinary. Dog Diseases / pathology. Heart Neoplasms / veterinary. Myxosarcoma / veterinary. Pituitary Neoplasms / veterinary
  • [MeSH-minor] Animals. Diagnosis, Differential. Dogs. Fatal Outcome. Female

  • MedlinePlus Health Information. consumer health - Pituitary Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20110224.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


93. Chiang KH, Liou JY, Shyu KG, Yeh CH, Wu CC, Chen TJ, Lo HM: Hypertension due to co-existing paraganglioma and unilateral adrenal cortical hyperplasia. J Formos Med Assoc; 2007 Dec;106(12):1043-7
MedlinePlus Health Information. consumer health - Pheochromocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypertension due to co-existing paraganglioma and unilateral adrenal cortical hyperplasia.
  • A rare case of combined unilateral adrenal hyperplasia and paraganglioma is reported.
  • Computed tomography showed a microadenoma of the left adrenal gland and a well demarcated left retroperitoneal para-aortic mass.
  • Adrenal vein sampling for aldosterone and renin levels suggested left adrenal lesion.
  • Surgical removal of the left adrenal gland and para-aortic mass was performed.
  • Pathologic examination of the resected left adrenal gland showed adrenal cortical hyperplasia and the left retroperitoneal para-aortic mass showed a paraganglioma.
  • The possible relationship of these two diseases is discussed.

  • Genetic Alliance. consumer health - Adrenal Hypertension.
  • MedlinePlus Health Information. consumer health - High Blood Pressure.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18194911.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  •  go-up   go-down


94. Herrera JD, Davidson JA, Mestman JH: Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature. Endocr Pract; 2009 Mar;15(2):149-52
Hazardous Substances Data Bank. TESTOSTERONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature.
  • OBJECTIVE: To report a case of hyperandrogenism attributable to the presence of an adrenal adenoma secreting dehydroepiandrosterone sulfate (DHEA-S) and an ovarian Sertoli-Leydig cell tumor secreting testosterone in a postmenopausal woman.
  • Laboratory tests showed elevated levels of total testosterone (348 ng/dL) and DHEA-S (2,058 microg/dL), and a left adrenal tumor (3 by 4 cm) was detected on abdominal computed tomographic scan.
  • Laparoscopic left adrenalectomy was performed, and the pathologic diagnosis was adrenal adenoma.
  • Bilateral oophorectomy was performed, and an ovarian Sertoli-Leydig cell tumor was diagnosed.
  • CONCLUSION: After extensive review of the literature, we believe that this is the first reported case of a coincidental DHEA-S-secreting adrenal adenoma and a testosterone- secreting ovarian Leydig cell tumor causing signs of virilization.
  • [MeSH-major] Adrenocortical Adenoma / metabolism. Dehydroepiandrosterone Sulfate / metabolism. Hyperandrogenism / diagnosis. Hyperandrogenism / etiology. Leydig Cell Tumor / metabolism. Testosterone / metabolism

  • Genetic Alliance. consumer health - Hyperandrogenism.
  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for adrenal adenoma .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19289327.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone; 57B09Q7FJR / Dehydroepiandrosterone Sulfate
  • [Number-of-references] 13
  •  go-up   go-down


95. Waalkes MP, Liu J, Ward JM, Diwan BA: Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen. Toxicol Appl Pharmacol; 2006 Sep 15;215(3):295-305
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Arsenic alone increased hepatocellular carcinoma (14%), adenoma (23%) and total tumors (31%) compared to control (0, 2 and 2%, respectively).
  • Arsenic alone also increased lung adenocarcinoma, adrenal cortical adenoma and renal cystic tubular hyperplasia compared to control.
  • The treatments alone did not impact urinary bladder carcinogenesis, but arsenic plus TAM significantly increased formation of urinary bladder transitional cell tumors (papilloma and carcinoma; 13%) compared to control (0%).
  • Thus, in male CD1 mice, gestational arsenic exposure alone induced liver adenoma and carcinoma, lung adenocarcinoma, adrenal adenoma and renal cystic hyperplasia.

  • MedlinePlus Health Information. consumer health - Arsenic.
  • MedlinePlus Health Information. consumer health - Bladder Cancer.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. TAMOXIFEN .
  • Hazardous Substances Data Bank. DIETHYLSTILBESTROL .
  • Hazardous Substances Data Bank. ARSENIC, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16712894.001).
  • [ISSN] 0041-008X
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogens, Non-Steroidal; 0 / Selective Estrogen Receptor Modulators; 094ZI81Y45 / Tamoxifen; 731DCA35BT / Diethylstilbestrol; N712M78A8G / Arsenic
  •  go-up   go-down


96. Stifelman MD, Fenig DM: Work-up of the functional adrenal mass. Curr Urol Rep; 2005 Feb;6(1):63-71
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Work-up of the functional adrenal mass.
  • Evaluation of a functional adrenal mass may be initiated based on symptomatic presentation or the detection of an incidental adrenal mass.
  • Recent literature suggests that 10% to 20% of adrenal incidentalomas demonstrate subclinical hormonal dysfunction, which may place patients at a higher risk for metabolic or cardiovascular disorders.
  • Many diagnostic algorithms have been proposed for the evaluation of pheochromocytoma, Cushing's adenoma, aldosteronoma, and hormonally active adrenal cortical carcinoma.
  • In this article, the available literature on functional adrenal masses is reviewed and up-to-date methods of efficient diagnosis are proposed.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Diagnostic Imaging / methods. Pheochromocytoma / diagnosis

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • MedlinePlus Health Information. consumer health - Diagnostic Imaging.
  • MedlinePlus Health Information. consumer health - Pheochromocytoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15610699.001).
  • [ISSN] 1527-2737
  • [Journal-full-title] Current urology reports
  • [ISO-abbreviation] Curr Urol Rep
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
  •  go-up   go-down


97. Gockel I, Heintz A, Kentner R, Werner C, Junginger T: Changing pattern of the intraoperative blood pressure during endoscopic adrenalectomy in patients with Conn's syndrome. Surg Endosc; 2005 Nov;19(11):1491-7
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Changing pattern of the intraoperative blood pressure during endoscopic adrenalectomy in patients with Conn's syndrome.
  • BACKGROUND: Primary hyperaldosteronism caused by an aldosterone-producing adenoma of the adrenal gland is regarded as the most common type of endocrine hypertension.
  • The aim of this study was to analyze the changing pattern of the intraoperative blood pressure during endoscopic adrenalectomy recorded in patients with Conn's syndrome compared to patients with hormone-inactive incidentaloma and its possible influence by the surgical approach.
  • METHODS: From February 1994 to March 2004, 40 patients underwent endoscopic adrenalectomy for Conn's syndrome.
  • RESULTS: The adrenal gland was resected using the retroperitoneal in 25 and the transperitoneal approach in 15 patients with Conn's syndrome.
  • The increase in intraoperative blood pressure in patients with Conn's syndrome was significantly higher, for both systolic (p < 0.0001) and diastolic (p = 0.0037) readings, compared to that in patients with incidentaloma undergoing endoscopic adrenalectomy during the same period of time.
  • CONCLUSION: Our results demonstrate that relevant intraoperative increases in blood pressure occur in patients with Conn's syndrome despite prior therapy with an aldosterone antagonist, necessitating specific precautionary measures during anesthesia.

  • Genetic Alliance. consumer health - Conn's Syndrome.
  • MedlinePlus Health Information. consumer health - Endoscopy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [ErratumIn] Surg Endosc. 2006 Jan;20(1):180. Wetner, C [corrected to Werner, C]
  • [Cites] World J Surg. 2003 Jun;27(6):627-31 [12732984.001]
  • [Cites] Surgery. 1994 May;115(5):621-5 [8178262.001]
  • [Cites] Surg Endosc. 2005 Apr;19(4):569-73 [15759181.001]
  • [Cites] Am Surg. 2000 Oct;66(10):932-5; discussion 935-6 [11261619.001]
  • [Cites] S Afr Med J. 1982 Jul 10;62(2):60-3 [7046100.001]
  • [Cites] Arch Surg. 1999 Jun;134(6):628-31; discussion 631-2 [10367872.001]
  • [Cites] J Urol. 2003 Jan;169(1):32-5 [12478096.001]
  • [Cites] Chirurg. 2004 Nov;75(11):1098-103 [15205748.001]
  • [Cites] Chirurg. 1997 Feb;68(2):154-8 [9156982.001]
  • [Cites] Surg Laparosc Endosc. 1999 Jan;9(1):9-13 [9950120.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Mar;86(3):1066-71 [11238487.001]
  • [Cites] Ann Surg. 1996 Dec;224(6):727-34; discussion 734-6 [8968227.001]
  • [Cites] J Hum Hypertens. 1992 Feb;6(1):75-6 [1583635.001]
  • [Cites] Ann Surg. 2000 Dec;232(6):796-803 [11088074.001]
  • [Cites] Am J Hypertens. 1990 Jul;3(7):576-82 [2194512.001]
  • [Cites] Biomed Pharmacother. 2000 Jun;54 Suppl 1:207s-210s [10915026.001]
  • [Cites] Ann Intern Med. 2001 Aug 21;135(4):258-61 [11511140.001]
  • [Cites] Endocrinology. 2003 Jun;144(6):2208-13 [12746276.001]
  • [Cites] Br J Surg. 1995 Feb;82(2):215 [7749696.001]
  • [Cites] Clin Exp Hypertens. 1997 Jul-Aug;19(5-6):885-99 [9247762.001]
  • (PMID = 16222471.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


98. Bourdeau I, Lampron A, Costa MH, Tadjine M, Lacroix A: Adrenocorticotropic hormone-independent Cushing's syndrome. Curr Opin Endocrinol Diabetes Obes; 2007 Jun;14(3):219-25
Hazardous Substances Data Bank. Corticotropin .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary Cushing's syndrome is most often secondary to adrenocortical adenomas or carcinomas, and more rarely to bilateral adrenal hyperplasias.
  • Corticotropin-independent cortisol-producing hyperplasia is caused by micronodular diseases, including primary pigmented nodular adrenocortical disease and nonpigmented micronodular hyperplasia and adrenocorticotropic hormone-independent macronodular adrenal hyperplasia.
  • Primary pigmented nodular adrenocortical disease can be found either alone or in the context of Carney complex, a multiple endocrine neoplasia syndrome.
  • RECENT FINDINGS: In recent years, the pathophysiology of adrenocortical tumors and hyperplasias became better understood following the identification of genes responsible for syndromes associated with corticotropin-independent Cushing's syndrome and the demonstration of aberrant expression and function of various hormone receptors in adrenocortical adenomas and adrenocorticotropic hormone-independent macronodular adrenal hyperplasia.
  • This article reviews findings on the molecular and genetic aspects of corticotropin-independent Cushing's syndrome including recent gene expression profiling studies of adrenocortical tumors and hyperplasias and animal models that provided clues on the pathogenesis of primary Cushing's syndrome.
  • SUMMARY: A better understanding of molecular mechanisms involved in adrenocortical tumors and hyperplasias may lead to improved diagnostic and prognostic markers and treatment strategies to assist clinicians in the management of corticotropin-independent Cushing's syndrome.
  • [MeSH-major] Adrenal Cortex Diseases / complications. Adrenal Cortex Neoplasms / complications. Adrenocorticotropic Hormone / metabolism. Cushing Syndrome / etiology

  • Genetic Alliance. consumer health - Cushing's Syndrome.
  • MedlinePlus Health Information. consumer health - Cushing's Syndrome.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17940443.001).
  • [ISSN] 1752-2978
  • [Journal-full-title] Current opinion in endocrinology, diabetes, and obesity
  • [ISO-abbreviation] Curr Opin Endocrinol Diabetes Obes
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone
  • [Number-of-references] 63
  •  go-up   go-down


99. Chien HP, Chang YS, Hsu PS, Lin JD, Wu YC, Chang HL, Chuang CK, Tsuei KH, Hsueh C: Adrenal cystic lesions: a clinicopathological analysis of 25 cases with proposed histogenesis and review of the literature. Endocr Pathol; 2008;19(4):274-81
MedlinePlus Health Information. consumer health - Adrenal Gland Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal cystic lesions: a clinicopathological analysis of 25 cases with proposed histogenesis and review of the literature.
  • Adrenal cystic lesions are uncommon and we analyzed clinical and pathologic features of 25 such cases from a single institute over 23 years.
  • The proposed mesothelial origin of adrenal epithelial cyst cannot be confirmed in our example.
  • Seven adrenal pseudocysts were associated with tumor, including two pheochromocytomas, one neuroblastoma, one adrenal cortical carcinoma, one adrenal cortical adenoma, one myelolipoma, and one schwannoma.
  • [MeSH-major] Adrenal Gland Diseases / pathology. Adrenal Glands / pathology. Cysts / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18972224.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 25
  •  go-up   go-down


100. Osman Y, El-Mekresh M, Gomha AM, Mohsen T, Taha N, Hussein N, Eraky I: Percutaneous adrenal biopsy for indeterminate adrenal lesion: complications and diagnostic accuracy. Urol Int; 2010;84(3):315-8
MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Percutaneous adrenal biopsy for indeterminate adrenal lesion: complications and diagnostic accuracy.
  • PURPOSE: To critically analyze the role, accuracy and safety of percutaneous adrenal biopsy for indeterminate adrenal lesions.
  • MATERIALS AND METHODS: Adrenal biopsies were performed in 15 among 214 patients (7%) diagnosed with adrenal masses being indeterminate on preoperative imaging.
  • There were 2 nonrepresentative biopsies that were proved to be adrenocortical carcinoma and myelolipoma after adrenalectomy.
  • Results of biopsy in the remaining 13 patients provided accurate diagnosis as proved by definitive histopathology in all but 2 in whom the final diagnosis was established as adrenocortical carcinoma while biopsy was paraganglioma in one and cortical adenoma in the other.
  • Overall sensitivity and negative predictive value of adrenal biopsy was 73.3 and 60%, respectively.
  • CONCLUSIONS: Percutaneous biopsy is a safe procedure for the diagnosis of pathologic conditions of the adrenal gland with a reasonable diagnostic aid.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20389162.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down






Advertisement