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1. Ungari C, Paparo F, Colangeli W, Iannetti G: Parotid glands tumours: overview of a 10-year experience with 282 patients, focusing on 231 benign epithelial neoplasms. Eur Rev Med Pharmacol Sci; 2008 Sep-Oct;12(5):321-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenoma is the most common benign epithelial salivary gland neoplasm, comprising 50%-74% of all parotid tumours.
  • It is followed by Warthin's tumour (4-14%).
  • Smoking habit is important in Warthin's tumour pathogenesis.
  • Tumour pseudopodia and capsule ruptures are recognised factors involved in pleomorphic adenoma recurrences but also tumour multicentricity might play an important role.

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  • (PMID = 19024217.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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2. Iwai H, Yamashita T: Local excision procedure for Warthin's tumor of the parotid gland. Otolaryngol Head Neck Surg; 2005 Apr;132(4):577-80
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  • [Title] Local excision procedure for Warthin's tumor of the parotid gland.
  • The aim of this work is to establish a local excision procedure (LEP) and indications of this procedure for Warthin's tumor.
  • Seventy-three patients (82 sides) with Warthin's tumor were studied.
  • For Warthin's tumor estimated to be below the I-S line (Group A), LEP was used, involving resection of the tumor after locating and dissecting the marginal mandibular and colli branches.
  • For tumors not meeting these criteria (Group B), partial superficial parotidectomy was performed.
  • Conversely, no significant difference in tumor size or incidence of postoperative facial paresis was identified between the 2 groups.
  • In conclusion, LEP is useful for Warthin's tumor below the I-S line.
  • This procedure seems applicable not only to Warthin's tumors, but also to other benign parotid tumors in the surgical field below the I-S line, such as pleomorphic adenoma and lymphoepithelial cyst.
  • [MeSH-major] Adenolymphoma / surgery. Microsurgery / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 15806048.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H: MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin Cancer Res; 2006 Jul 1;12(13):3902-7
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  • Mucoepidermoid carcinoma translocated gene 1-mastermind-like gene family (MECT1-MAML2) gene fusion was identified from a recurring t(11;19)(q21;p13) translocation, which is often the sole cytogenetic alteration in this disease.
  • EXPERIMENTAL DESIGN: Seventy-one cases of mucoepidermoid carcinoma and 51 cases of nonmucoepidermoid carcinoma salivary gland tumors (including 26 Warthin tumor cases) were retrospectively analyzed.
  • RESULTS: The MECT1-MAML2 fusion transcript was detected in 27 of the 71 (38%) mucoepidermoid carcinoma cases but not in any case of nonmucoepidermoid carcinoma tumors.
  • Detection of the MECT1-MAML2 fusion transcript was associated with a less advanced clinical stage and a low-grade tumor histology.
  • The presence of the transcript was associated with longer disease-free and overall survivals on univariate analysis and emerged as an independent prognostic factor for longer overall survival on multivariate analysis.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Disease-Free Survival. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic / genetics. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Retrospective Studies. Reverse Transcriptase Polymerase Chain Reaction / methods. Survival Rate

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  • [CommentIn] Clin Cancer Res. 2006 Jul 1;12(13):3878-81 [16818681.001]
  • (PMID = 16818685.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
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4. Mardi K, Sharma J: Mucoepidermoid carcinoma arising in Warthin's tumor: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):331-3
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  • [Title] Mucoepidermoid carcinoma arising in Warthin's tumor: a case report.
  • Malignant transformation of the epithelial component of Warthin's tumor is extremely rare.
  • We describe our experience of mucoepidermoid carcinoma arising in Warthin's tumor of the parotid gland in a 35 year old female.
  • The tumor removed from the parotid region was well encapsulated and histologically comprised ofmucoepidermoid carcinoma along with areas of Warthin's tumor.
  • [MeSH-major] Adenolymphoma / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Second Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17883061.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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5. Arvanitis DL, Arvanitis LD, Panourias IG, Kitsoulis P, Kanavaros P: Mitochondria-rich normal, metaplastic, and neoplastic cells show overexpression of the epitope H recognized by the monoclonal antibody H. Pathol Res Pract; 2005;201(4):319-24
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  • Immunohistochemical staining for the mAbH was observed in oxyphil cells of parathyroid glands, in striated duct cells of parotid glands, in urinary tubules of kidneys, in parietal cells of gastric body mucosa, in oxyphil cells of Hashimoto's thyroiditis, in epithelial cells of Warthin's tumors of the parotid gland, in neoplastic cells of oxyphil adenomas and carcinomas (Hürthle's tumors) of the thyroid gland, and in neoplastic cells of oncocytomas of the kidneys.
  • These findings may be of interest for gaining insight into the histophysiology of mitochondria-rich normal cells and into the pathogenesis of oncocytic lesions, since O-GlcNAc glycosylation may modify proteins involved in oncogenesis such as tumor suppressor proteins and oncoproteins, as well as proteins with important biological functions such as cytoskeletal proteins, transcription factors, heat-shock proteins, and chromatin proteins.
  • [MeSH-minor] Antigens, Neoplasm / immunology. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / immunology. Biomarkers, Tumor / metabolism. Epitopes / immunology. Epitopes / metabolism. Fluorescent Antibody Technique, Indirect. Humans. Immunoenzyme Techniques. Metaplasia / immunology. Metaplasia / metabolism. Metaplasia / pathology

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  • (PMID = 15991839.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Epitopes; V956696549 / Acetylglucosamine
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6. Arida M, Barnes EL, Hunt JL: Molecular assessment of allelic loss in Warthin tumors. Mod Pathol; 2005 Jul;18(7):964-8
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  • [Title] Molecular assessment of allelic loss in Warthin tumors.
  • Warthin's tumors are benign lesions of the head and neck that have a characteristic morphologic appearance.
  • The etiology of Warthin's tumors is controversial and whether they are true neoplasms or developmental malformations continues to be debated.
  • In this study, we examined 12 Warthin tumors with a molecular and immunohistochemical approach.
  • The epithelial and lymphoid components of each lesion were microdissected and PCR was performed for 13 microsatellite markers at or near common tumor suppressor genes.
  • The epithelial component of all tumors was negative for p53 and p16ink.
  • The immunohistochemical and molecular results in this study lend support to the hypothesis that Warthin tumors are non-neoplastic, as there was no evidence of aberrant staining for tumor suppressor gene protein products and no evidence of consistent clonal allelic losses.
  • [MeSH-major] Loss of Heterozygosity. Parotid Neoplasms / pathology. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Aged. Cyclin-Dependent Kinase Inhibitor p16 / analysis. DNA, Neoplasm / analysis. DNA, Neoplasm / genetics. Electrophoresis, Capillary. Female. Genotype. Humans. Immunohistochemistry. Male. Middle Aged. Tumor Suppressor Protein p53 / analysis. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 15861216.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins
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7. Guldfred LA, Becker BC, Eiholm S: [Multiple synchronous tumours of different histological type of the salivary glands]. Ugeskr Laeger; 2008 Apr 28;170(18):1571
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  • [Transliterated title] Multiple synkrone tumorer med forskellig histologi i de store spytkirtler.
  • Here we report a 72-year-old woman who was diagnosed with simultaneously occurring Warthin's tumour of the left parotid and mixed tumour of the homolateral submandibular gland.
  • This case also illustrates the importance of thorough examination even after the identification of a single tumour, as multiple synchronous primary tumours--even if rare--can be a diagnostic possibility.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 18454930.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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8. Song K, Cotelingam JD, Lowery-Nordberg M, Sun W: Characterization of the lymphoid stroma in Warthin's tumor of salivary gland by immunohistochemistry, heavy chain gene and Bcl-2 gene rearrangement. Am J Transl Res; 2009;1(4):352-7
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  • [Title] Characterization of the lymphoid stroma in Warthin's tumor of salivary gland by immunohistochemistry, heavy chain gene and Bcl-2 gene rearrangement.
  • Warthin's tumor is rarely associated with malignant lymphoma.
  • In most cases the latter is a low grade process, including Marginal zone/Mucosa associated lymphoid tissue (MALT) type lymphoma, follicular lymphoma, and rarely diffuse large cell lymphoma which may arise de novo or secondary to low grade lymphoma.
  • This study was conducted to determine the prevalence of occult B cell monoclones and genetic alterations in Warthin's tumor.
  • Fourteen cases of Warthin's tumor were stained with antibodies to CD3, CD20, kappa and lambda light chains.
  • On six cases of randomly selected Warthin's tumor, polymerase chain reaction (PCR) of IgH gene rearrangement (IgH-GR) was performed on genomic DNA extracted from formalin-fixed paraffin embedded tissue.
  • In all Warthin's tumor and sialadenitis cases most of lymphoid stroma was B cell phenotype and concentrated in germinal centers.
  • Our study concludes that the lymphoid stroma of Warthin's tumor is reactive.

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  • (PMID = 19956447.001).
  • [ISSN] 1943-8141
  • [Journal-full-title] American journal of translational research
  • [ISO-abbreviation] Am J Transl Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780035
  • [Keywords] NOTNLM ; Warthin's tumor / gene rearrangement / immunohistochemistry / lymphoid stroma
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9. Jezewska E, Scinska A, Kukwa W, Bienkowski P: Effects of benign parotid tumors on unstimulated saliva secretion from the parotid gland. Auris Nasus Larynx; 2009 Oct;36(5):586-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of benign parotid tumors on unstimulated saliva secretion from the parotid gland.
  • OBJECTIVE: Salivary tumors can manifest as abnormalities of the gland itself and/or changes in salivary flow.
  • However, effects of salivary tumors on saliva secretion have not been studied in much detail.
  • The aim of the present study was to evaluate effects of benign parotid tumors on unstimulated saliva secretion from the affected gland.
  • METHODS: Unstimulated parotid saliva was collected bilaterally using the swab method in patients with unilateral pleomorphic adenoma (n=14) or Warthin's tumor (n=6).
  • No difference was found between the involved and non-involved side when the patients with pleomorphic adenoma or Warthin's tumor were separately analyzed.
  • CONCLUSION: The present results suggest that the most common benign parotid tumors do not alter unstimulated salivary flow from the affected gland.
  • [MeSH-major] Adenolymphoma / secretion. Adenoma, Pleomorphic / secretion. Parotid Gland / secretion. Parotid Neoplasms / secretion. Saliva / secretion

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  • (PMID = 19249167.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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10. Becelli R, Morello R, Renzi G, Dominici C: Warthin's tumor of the hard palate. J Craniofac Surg; 2007 Sep;18(5):1182-4
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  • [Title] Warthin's tumor of the hard palate.
  • Warthin's Tumor (WT) or papillary cystadenoma lymphomatosum is typically located in parotid gland.
  • [MeSH-major] Adenolymphoma / pathology. Palatal Neoplasms / pathology. Palate, Hard / pathology

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  • (PMID = 17912110.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Moore FO, Abdel-Misih RZ, Berne JD, Zieske AW, Rana NR, Ryckman JG: Poorly differentiated carcinoma arising in a Warthin's tumor of the parotid gland: pathogenesis, histopathology, and surgical management of malignant Warthin's tumors. Am Surg; 2007 Apr;73(4):397-9
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  • [Title] Poorly differentiated carcinoma arising in a Warthin's tumor of the parotid gland: pathogenesis, histopathology, and surgical management of malignant Warthin's tumors.
  • Warthin's tumor is a benign lymphoepithelial neoplasm representing 10 per cent of all parotid gland tumors.
  • Malignant transformation of a Warthin's tumor is an extremely rare event.
  • We report a case of a patient with poorly differentiated carcinoma arising from a Warthin's tumor, as well as review the pathogenesis, histopathology, and surgical management of malignant Warthin's tumors.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17439037.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Halimi P, Gardner M, Petit F: [Tumors of the salivary glands]. Cancer Radiother; 2005 Jun;9(4):251-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumors of the salivary glands].
  • Tumors of salivary glands arise mainly from the parotid gland.
  • Magnetic Resonance Imaging (MRI) is mandatory not only to localize precisely the tumor within the gland but also to differentiate between benign and malignant neoplasms, in competition with cytology in fine-needle aspiration biopsy.
  • Tumors without risk of transformation, such as adenolymphoma, are not systematically operated on.
  • Indications of roentgenotherapy and irradiation volumes depend on histologic type, localisation and size of the tumor.
  • [MeSH-major] Adenolymphoma / pathology. Adenolymphoma / radiotherapy. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / radiotherapy

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  • (PMID = 16019247.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 37
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13. Roh JL, Kim JM, Park CI: Synchronous benign and malignant tumors in the ipsilateral parotid gland. Acta Otolaryngol; 2007 Jan;127(1):110-2
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  • [Title] Synchronous benign and malignant tumors in the ipsilateral parotid gland.
  • Synchronous benign and malignant tumors in the ipsilateral salivary glands are extremely rare.
  • We report a unique case of synchronous unilateral parotid tumors in a 71-year-old man.
  • A coexisting Warthin's tumor was also diagnosed on microscopic examination of total parotidectomy specimens.
  • We describe this case of rare synchronous salivary gland tumors exhibiting both benign and malignant components with a review of the literature.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / radiography. Adenolymphoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 17364340.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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14. Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H, Griffin JD: Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. EMBO J; 2005 Jul 6;24(13):2391-402
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  • Salivary gland tumors, a group of histologically diverse benign and malignant neoplasms, represent a challenging problem for diagnosis and treatment.
  • A specific recurring t(11;19)(q21;p13) translocation is associated with two types of salivary gland tumors, mucoepidermoid carcinomas and Warthin's tumors.
  • This study has identified a novel, critical mechanism of transformation for an oncogene associated very specifically with salivary gland tumors, and identified potential targets for the development of novel therapies.

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  • (PMID = 15961999.001).
  • [ISSN] 0261-4189
  • [Journal-full-title] The EMBO journal
  • [ISO-abbreviation] EMBO J.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA036167; United States / NCI NIH HHS / CA / R01 CA097148; United States / NCI NIH HHS / CA / R37 CA036167
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CREB1 protein, human; 0 / Cyclic AMP Response Element-Binding Protein; 0 / MECT1-MAML2 fusion protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / Trans-Activators; 0 / Transcription Factors; E0399OZS9N / Cyclic AMP
  • [Other-IDs] NLM/ PMC1173159
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15. Gierek T, Majzel K, Jura-Szołtys E, Slaska-Kaspera A, Witkowska M, Klimczak-Gołab L: [A 20-year retrospective histoclinical analysis of parotid gland tumors in the ENT Department AM in Katowice]. Otolaryngol Pol; 2007;61(4):399-403
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  • [Title] [A 20-year retrospective histoclinical analysis of parotid gland tumors in the ENT Department AM in Katowice].
  • We analysed surgical treatment and intraoperative tumour stage.
  • The most frequent tumour was pleomorphic adenoma--75% and adenolymphoma--16%.
  • Mucoepidermoid (27%) and adenoid cyst (22%) carcinomas were the most common malignant tumour.
  • Tumour stages T3-T4 was in 90%.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Parotid Neoplasms / epidemiology

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  • (PMID = 18260221.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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16. Abd-Elhamid ES, Elshafei MM: Immunohistochemical localization of mdm-2, p27Kip1 and bcl-2 in Warthin's tumor of the parotid gland. Diagn Pathol; 2009;4:14
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  • [Title] Immunohistochemical localization of mdm-2, p27Kip1 and bcl-2 in Warthin's tumor of the parotid gland.
  • BACKGROUND: Warthin's tumor is a benign monomorphic adenoma with unclear origin that almost occur exclusively in the parotid gland.
  • Etiology of Warthin's tumor as well as its malignant potential are still unclear.
  • Therefore immunohistochemical assessment of Warthin's tumor may be useful to detect its origin or its malignant transformation potential.
  • AIMS AND OBJECTIVES: The present study aims to investigate the immunohistochemical expression of murine double minute-2 (mdm-2), p27Kip1 and B cell lymphoma-2 (bcl-2) in Warthin's tumor of parotid gland and also to clarify the role of these proteins in the behavior of that tumor.
  • METHODS: Twenty paraffin blocks of cases previously diagnosed as Warthin's tumor were collected for immunohistochemical staining with primary antibodies against mdm-2, p27Kip1 and bcl-2 using streptavidin-biotin immunoperoxidase staining system.
  • CONCLUSION: Mdm-2 played a tumor-suppressor role that might be implicated with the benign behavior of Warthin's tumor.

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  • (PMID = 19445705.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2693442
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17. Lardinois D, Weder W, Roudas M, von Schulthess GK, Tutic M, Moch H, Stahel RA, Steinert HC: Etiology of solitary extrapulmonary positron emission tomography and computed tomography findings in patients with lung cancer. J Clin Oncol; 2005 Oct 1;23(28):6846-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histopathologic examinations of these 32 lesions revealed a second clinically unsuspected malignancy or a recurrence of a previous diagnosed carcinoma in six patients (19%) and a benign tumor or inflammatory lesion in 26 patients (81%).
  • Benign tumors and inflammatory lesions included eight colon adenomas, four Warthin's tumors, one granuloma of the lower jaw, one adenoma of the thyroid gland, one compensatory muscle activity due to vocal chord palsy, two occurrences of arthritis, three occurrences of reflux esophagitis, two occurrences of pancreatitis, two occurrences of diverticulitis, one hemorrhoidal inflammation, and one rib fracture.
  • CONCLUSION: Solitary extrapulmonary FDG accumulations in patients with newly diagnosed lung cancer should be analyzed critically for correct staging and optimal therapy, given that up to half of the lesions may represent unrelated malignancies or benign disease.

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  • (PMID = 16192576.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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18. Edwards PC, Wasserman P: Evaluation of cystic salivary gland lesions by fine needle aspiration: an analysis of 21 cases. Acta Cytol; 2005 Sep-Oct;49(5):489-94
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  • This included 9 Warthin's tumors, 2 mucoepidermoid carcinomas, 2 simple cysts, 1 cystadenoma and 1 abscess.
  • [MeSH-minor] Abscess / pathology. Adenolymphoma / pathology. Biopsy, Fine-Needle. Carcinoma, Mucoepidermoid / pathology. Cystadenoma / pathology. Diagnosis, Differential. Extracellular Fluid / metabolism. Histiocytes / pathology. Humans. Lymphocytes / pathology. Observer Variation. Predictive Value of Tests. Reproducibility of Results. Retrospective Studies

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  • [CommentIn] Acta Cytol. 2007 Jul-Aug;51(4):675-6 [17718154.001]
  • (PMID = 16334024.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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19. Nouraei SA, Ismail Y, Ferguson MS, McLean NR, Milner RH, Thomson PJ, Welch AR: Analysis of complications following surgical treatment of benign parotid disease. ANZ J Surg; 2008 Mar;78(3):134-8
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  • [Title] Analysis of complications following surgical treatment of benign parotid disease.
  • BACKGROUND: The objective of the study was to study the incidence of, and risk factors for developing complications following parotidectomy for benign disease, to improve preoperative patient counselling and better inform future surgical management.
  • METHODS: An 11-year retrospective review of 162 parotidectomies for benign disease, collecting and analysing data about presentation, investigations, surgical treatment, postoperative facial nerve function, Frey's syndrome and other surgical complications.
  • The commonest pathology was benign pleomorphic adenoma (43%), followed by Warthin's tumour (30%) and chronic sialadenitis (22%).
  • Operations for Warthin's tumour were associated with an increased risk of dysfunction of the cervical branch of the nerve.
  • [MeSH-minor] Adenolymphoma / pathology. Adenolymphoma / surgery. Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Female. Humans. Immunohistochemistry. Incidence. Male. Middle Aged. Prognosis. Retrospective Studies. Risk Assessment. Sex Distribution. Sialadenitis / pathology. Sialadenitis / surgery. South Australia / epidemiology

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  • (PMID = 18269474.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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20. Fodor D, Pop S, Maniu A, Cosgaria M: Gray scale and Doppler ultrasonography of the benign tumors of parotid gland (pleomorphic adenoma and Warthin's tumor). Pictorial essay. Med Ultrason; 2010 Sep;12(3):238-44
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  • [Title] Gray scale and Doppler ultrasonography of the benign tumors of parotid gland (pleomorphic adenoma and Warthin's tumor). Pictorial essay.
  • The purpose of this pictorial essay is to illustrate the ultrasonographic aspects of the most common benign tumors of the parotid gland: pleomorphic adenoma and Warthin's tumor.
  • The gray scale and Doppler ultrasonographic findings of the two tumors are reviewed and exemplified.
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Parotid Neoplasms / ultrasonography. Ultrasonography, Doppler

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  • (PMID = 21203603.001).
  • [ISSN] 1844-4172
  • [Journal-full-title] Medical ultrasonography
  • [ISO-abbreviation] Med Ultrason
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
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21. Iwai H, Yamashita T: [Surgical procedure for Warthin's tumor in the parotid gland]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Jun;108(6):679-83
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  • [Title] [Surgical procedure for Warthin's tumor in the parotid gland].
  • Warthin's tumor is benign and exclusively involves the parotid gland but may, however, often show multifocal and/or bilateral growth.
  • The aim of this study was to evaluate the surgical procedure for removal of this tumor.
  • Sixty patients with Warthin's tumor in the parotid gland who presented at the Kansai Medical University Hospital from 1990 to 1999 were the subjects of the present study.
  • We performed enucleation for tumors in the deep lobe.
  • Tumors in the superficial lobe were resected with partial parotidectomy, and an enucleative procedure was also performed at the bottom of the tumor where the tumor capsule directly touched the facial nerve.
  • Therefore, we recommend that enucleation is a useful choice as a surgical procedure for the removal of Warthin's tumor after accurate detection of the tumors using MRI.
  • The incidence of palsy increased after surgery for multiple tumors or deep lobe tumors.
  • These findings indicate that more careful consideration for preservation of the facial nerve should be given in such cases and that simultaneous surgery for such tumors in the bilateral parotid glands should be avoided to prevent bilateral facial nerve palsy.
  • [MeSH-major] Adenolymphoma / surgery. Otorhinolaryngologic Surgical Procedures / methods. Parotid Neoplasms / surgery

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  • (PMID = 16001725.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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22. Gekeler J, Luers JC, Krohn T, Beutner D: False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland. Clin Nucl Med; 2010 Feb;35(2):105-6
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  • [Title] False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland.
  • [MeSH-major] Adenolymphoma / radionuclide imaging. Adenolymphoma / radiotherapy. Fluorodeoxyglucose F18. Parotid Neoplasms / radionuclide imaging. Parotid Neoplasms / radiotherapy

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  • (PMID = 20090459.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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23. Burgess AN, Serpell JW: Parotidectomy: preoperative investigations and outcomes in a single surgeon practice. ANZ J Surg; 2008 Sep;78(9):791-3
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  • RESULTS: The most common histopathology was benign lesions (89.6%), including pleomorphic adenoma (55.8%) and Warthin's tumour (11.7%).

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  • [CommentIn] ANZ J Surg. 2010 Mar;80(3):198-9 [20575936.001]
  • (PMID = 18844910.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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24. Woo PC, Tse H, Lau SK, Leung KW, Woo GK, Wong MK, Ho CM, Yuen KY: Alkanindiges hongkongensis sp. nov. A novel Alkanindiges species isolated from a patient with parotid abscess. Syst Appl Microbiol; 2005 Jun;28(4):316-22
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  • A bacterium was isolated from the abscess pus of a 72-year-old patient with Warthin's tumor and parotid abscess.
  • [MeSH-minor] Acinetobacter / genetics. Adenolymphoma / complications. Adenolymphoma / microbiology. Aerobiosis. Aged. Base Composition. DNA, Bacterial / chemistry. DNA, Bacterial / isolation & purification. DNA, Ribosomal / chemistry. DNA, Ribosomal / isolation & purification. Genes, rRNA. Hong Kong. Humans. Male. Molecular Sequence Data. Parotid Neoplasms / complications. Parotid Neoplasms / microbiology. Phylogeny. RNA, Ribosomal, 16S / genetics. Transformation, Bacterial

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  • (PMID = 15997704.001).
  • [ISSN] 0723-2020
  • [Journal-full-title] Systematic and applied microbiology
  • [ISO-abbreviation] Syst. Appl. Microbiol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AF543466/ AY251390/ AY251391
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Bacterial; 0 / DNA, Ribosomal; 0 / RNA, Ribosomal, 16S
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25. Viguer JM, Vicandi B, Jiménez-Heffernan JA, López-Ferrer P, González-Peramato P, Castillo C: Role of fine needle aspiration cytology in the diagnosis and management of Warthin's tumour of the salivary glands. Cytopathology; 2010 Jun;21(3):164-9
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  • [Title] Role of fine needle aspiration cytology in the diagnosis and management of Warthin's tumour of the salivary glands.
  • OBJECTIVE: Local excision surgical procedures and non-surgical conservative management are considered alternatives to superficial parotidectomy in the treatment and management of Warthin's tumour (WT).
  • One tumour diagnosed as WT was a low-grade mucoepidermoid carcinoma.
  • Cytology, when coupled with clinical and image findings, may permit conservative tumour management.
  • [MeSH-major] Adenolymphoma / diagnosis. Adenolymphoma / therapy. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / therapy. Salivary Glands / pathology

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  • [CommentIn] Cytopathology. 2010 Dec;21(6):423; author reply 423 [20726866.001]
  • (PMID = 19744189.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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26. Mihashi H, Kawahara A, Kage M, Kojiro M, Nakashima T, Umeno H, Sakamoto K, Chiziwa H: Comparison of preoperative fine-needle aspiration cytology diagnosis and histopathological diagnosis of salivary gland tumors. Kurume Med J; 2006;53(1-2):23-7
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  • [Title] Comparison of preoperative fine-needle aspiration cytology diagnosis and histopathological diagnosis of salivary gland tumors.
  • We investigated 115 patients with salivary gland epithelial tumors who had undergone preoperative fine needle aspiration cytology (FNAC) of salivary glands and had been diagnosed by postoperative histopathological examination.
  • We compared the findings of preoperative FNAC with their histopathological types in salivary gland tumors, and discuss the results and problems.
  • The rates of agreement in the diagnosis of pleomorphic adenoma, Warthin tumor, and basal cell adenoma were 96%, 92.9%, and 55.5%, respectively.
  • The rate of agreement of histopathological types in the malignant tumors was 30%.
  • We realized again not only that the diagnostic accuracy of preoperative FNAC for salivary gland tumors was high, but also that it was a safe, easy-to-perform, clinically very useful diagnostic procedure.
  • However, this study exposed several problems which are the inadequate sampling rate and the difficulty in diagnosing malignant tumors.

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  • (PMID = 17043392.001).
  • [ISSN] 0023-5679
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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27. Fiorella R, Di Nicola V, Fiorella ML, Spinelli DA, Coppola F, Luperto P, Madami L: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):182-90
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  • Benign tumours account for 80% of case histories with a relationship 1:4 M/F, the most frequent being pleomorphic adenoma (57.3% of cases), followed by Warthin's tumour (32.4%), this rating not having been confirmed in case histories (8-10%) in the literature.
  • Enucleoresection was limited to approximately 15% of neoplasms, enucleation to <10% of cases with only 2% of pleomorph adenoma due to the well-known anatomo-pathological characteristics which may lead to relapse.
  • When no clinically evident lymph nodes were present (NO) considering the tumour histotype, two thirds of patients underwent surgery or radiotherapy, while in the remainder the wait-and-see attitude was prefered.

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  • [ErratumIn] Acta Otorhinolaryngol Ital. 2005 Oct;25(5):following 337
  • (PMID = 16450775.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639866
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28. Kanazawa T, Ohta Y, Goutsu K, Takeoda K, Tsubaki K, Kodama K, Inoue R, Usubuchi H, Iino Y: [Significant factors affecting the operation time for benign parotid tumor]. Nihon Jibiinkoka Gakkai Kaiho; 2008 Jun;111(6):481-5
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  • [Title] [Significant factors affecting the operation time for benign parotid tumor].
  • Tumors of the parotid gland are fairly frequent among head and neck tumors.
  • Parotidectomy for benign tumors is necessary for diagnosis and therapy.
  • To measure the operation time and determine the factors affecting it, 71 cases, including 43 cases of pleomorphic adenomas and 28 cases Warthin's tumor, were retrospectively reviewed to the determine if the operation time depended on the age, sex, operated side, presence of complications, BMI, bleeding volume, tumor size, tumor location, exposure of branches of the facial nerve, and experience of the surgeon.
  • The results revealed that the bleeding volume, tumor size, tumor location and experience of the surgeon were significantly correlated with the operation time, whereas age, sex, operated side, presentation of complications and BMI showed no correlation with the operation time.
  • Taken together, to shorten the operation time, the inexperienced surgeon should start with smaller tumors and surgery in the superficial lobe in the initial training period, and supervision by well-experienced supervised surgeons is required until 30-40 are undertaken.

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  • (PMID = 18634454.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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29. Ochicha O, Malami S, Mohammed A, Atanda A: A histopathologic study of salivary gland tumors in Kano, northern Nigeria. Indian J Pathol Microbiol; 2009 Oct-Dec;52(4):473-6
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  • [Title] A histopathologic study of salivary gland tumors in Kano, northern Nigeria.
  • Significant differences in the global distribution of salivary gland tumors have been reported, but no formal study has been carried out here in Kano, the largest city in northern Nigeria.
  • Seventy-eight salivary gland tumors were diagnosed during the eight-year study period accounting for 0.4% of all neoplasms.
  • Benign tumors were more prevalent, comprising 56.4%, while malignancies were 43.6%.
  • Pleomorphic adenoma and mucoepidermoid carcinoma were the commonest histological types constituting 48.7% and 23.1% respectively, while the most frequent sites were parotid, submandibular and minor salivary glands accounting for 49%, 26% and 24% respectively.
  • As in most studies of black populations there were no adenolymphomas.
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / pathology. Adolescent. Adult. Age Factors. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Mucoepidermoid / pathology. Female. Histocytochemistry. Humans. Male. Middle Aged. Nigeria / epidemiology. Prevalence. Salivary Glands / pathology. Young Adult

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  • (PMID = 19805949.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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30. Pietniczka-Załeska M, Dabrowska-Bień J: [Parotid tumors: a two-year experience of Otolaryngology Department at MSS Hospital in Warsaw]. Otolaryngol Pol; 2009 Sep;63(7):43-6
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  • [Title] [Parotid tumors: a two-year experience of Otolaryngology Department at MSS Hospital in Warsaw].
  • THE AIM OF THE STUDY: Tumors of the salivary glands represent about 3% of head and neck neoplasms.
  • All of the patients had ultrasound examination prior to operation to estimate the spread and the type of the tumor.
  • RESULTS: The frequency of incidence of benign tumours was 90% and the most frequent histopathological diagnosis was pleomorphic adenoma (49%) and adenolymphoma (42%).
  • CONCLUSION: Superficial and total parotidectomy are safe procedures of treatment in case of salivary gland tumors.

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  • (PMID = 20564899.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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31. Andreadis D, Epivatianos A, Poulopoulos A, Nomikos A, Christidis K, Papazoglou G, Antoniades D, Barbatis C: Immunohistochemical detection of the expression of the cell adhesion molecules E-cadherin, desmoglein-2, beta4-integrin, ICAM-1 and HCAM (CD44s) in Warthin's tumour of the parotid gland. Oral Oncol; 2005 Sep;41(8):799-805
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical detection of the expression of the cell adhesion molecules E-cadherin, desmoglein-2, beta4-integrin, ICAM-1 and HCAM (CD44s) in Warthin's tumour of the parotid gland.
  • The study of the expression of cell adhesion molecules (CAMs), E-cadherin, desmoglein-2, beta4-integrin, HCAM (CD44s) and ICAM-1 in Warthin's tumours.
  • Twenty formalin--fixed, paraffin--embedded parotid Warthin's tumours were studied using an Envision/HRP immunohistochemical technique.
  • CAM expression suggests a bilayered excretory ductal structure of the neoplastic epithelium in Warthin's tumour, as a result of hyperplastic process of the glandular epithelium that interacts with the excessive lymphoid tissue of the stroma.
  • [MeSH-major] Adenolymphoma / metabolism. Cell Adhesion Molecules / metabolism. Integrin beta4 / metabolism. Neoplasm Proteins / metabolism. Parotid Neoplasms / metabolism

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  • (PMID = 16043382.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Cell Adhesion Molecules; 0 / Desmoglein 2; 0 / Integrin beta4; 0 / Neoplasm Proteins
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32. Nakahara T, Suzuki T, Hashimoto J, Shigematsu N, Tomita T, Ogawa K, Kubo A: Role of salivary gland scintigraphy with Tc-99m pertechnetate in determining treatment of solitary parotid gland tumors: a retrospective study. Clin Nucl Med; 2007 May;32(5):363-6
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  • [Title] Role of salivary gland scintigraphy with Tc-99m pertechnetate in determining treatment of solitary parotid gland tumors: a retrospective study.
  • PURPOSE OF THE REPORT: Although salivary gland scintigraphy has been useful for the diagnosis of Warthin's tumor (WT), there are no reports concerning the clinical impact of this scintigraphy.
  • MATERIALS AND METHODS: We retrospectively investigated 127 patients with solitary parotid tumors who had undergone salivary gland scintigraphy.

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  • (PMID = 17452863.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] A0730CX801 / Sodium Pertechnetate Tc 99m
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33. Chakrabarti S, Bera M, Bhattacharya PK, Chakrabarty D, Manna AK, Pathak S, Maiti K: Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry. J Indian Med Assoc; 2010 Dec;108(12):833-6
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  • Pre-operative core needle biopsy is hazardous and may damage facial nerve, lead to fistula formation or associated with tumour seeding.
  • Among these 3 cases, 2 were adenoid cystic carcinoma which was cytologically diagnosed as benign neoplasm (monomorphic adenoma).
  • One case of Warthin's tumour was cytologically diagnosed as pleomorphic adenoma.

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  • (PMID = 21661459.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] India
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34. Leibowitz JM, Montone KT, Basu D: Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. Head Neck; 2010 Jan;32(1):133-6
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  • [Title] Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature.
  • Definitive excision ultimately demonstrated Candida glabrata infecting a Warthin tumor.
  • The case also expands the spectrum of disease associated with C. glabrata.
  • Warthin tumor may be an occult etiology for a parotid fungal abscess, and definitive diagnosis and therapy may require parotidectomy.
  • [MeSH-major] Abscess / surgery. Adenolymphoma / surgery. Candida glabrata. Candidiasis / surgery. Immunocompetence. Parotid Neoplasms / surgery

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  • (PMID = 19340859.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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35. Oda E, Nakamura Y, Yamamoto M, Kojiro M: Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues. Kurume Med J; 2005;52(4):117-25
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  • In neoplastic tissues, tubulin beta II immunoreactivity was detected in various nervous system neoplasms and other neoplasms such as pancreatic solid cystic carcinoma, pleomorphic adenoma, Warthin's tumor, nephroblastoma, basal cell carcinoma and malignant mesothelioma.
  • We conclude that our monoclonal antibody, KNY379, may be useful as a marker of nervous system neoplasm, pancreatic solid cystic carcinoma, pleomorphic adenoma, Warthin's tumor, nephroblastoma, basal cell carcinoma and malignant mesothelioma.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Blotting, Western. Child, Preschool. Humans. Immunohistochemistry. Infant. Mesothelioma / chemistry. Middle Aged. Protein Isoforms

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  • (PMID = 16639982.001).
  • [ISSN] 0023-5679
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protein Isoforms; 0 / Tubulin
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36. Berrocal Postigo E, Galera Ruiz H, Ruiz Clemente J, González García J, Muñoz Borge F: [Ectopic Warthin's tumour in nasopharynx. Revision of one clinical case]. Acta Otorrinolaringol Esp; 2005 Aug-Sep;56(7):328-30
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  • [Title] [Ectopic Warthin's tumour in nasopharynx. Revision of one clinical case].
  • [Transliterated title] Tumor de warthin ectópico en la nasofaringe. A propósito de un caso clínico.
  • A CT scan is informed as a well delimited and rounded-shaped tumour compatible with lymphoma.
  • Excisional biopsy by a nasal rigid endoscopy is practiced and the histology result is Warthin's tumour.
  • [MeSH-major] Adenolymphoma / pathology. Adenolymphoma / radiography. Choristoma / pathology. Choristoma / radiography. Nasopharyngeal Neoplasms / pathology. Nasopharyngeal Neoplasms / radiography. Nasopharynx

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  • (PMID = 16240924.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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37. Ascani G, Pieramici T, Rubini C, Messi M, Balercia P: Synchronous bilateral Warthin's tumours of the parotid glands: a case report. Acta Otorhinolaryngol Ital; 2010 Dec;30(6):310-2
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  • [Title] Synchronous bilateral Warthin's tumours of the parotid glands: a case report.
  • Warthin's tumour is the most frequent monomorphic adenoma of the major salivary glands, representing about 2-15% of all parotid tumours.
  • Most of the multifocal Warthin's tumours are unilateral, whereas bilateral Warthin's tumours are far less common; bilateral Warthin's tumours are metachronous with few synchronous cases having been described in the literature.
  • The Authors present an interesting case of simultaneously occurring bilateral Warthin's tumours growing in the parotid glands.
  • [MeSH-major] Adenolymphoma / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • [Cites] Eur Arch Otorhinolaryngol. 2008 Dec;265(12):1573-5 [18301907.001]
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  • (PMID = 21808453.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3146325
  • [Keywords] NOTNLM ; Bilateral tumours / Multifocal tumours / Parotid gland / Salivary gland tumours / Warthin's tumour
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38. Yerli H, Avci S, Aydin E, Arikan U: The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Mar;109(3):e95-8
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  • [Title] The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case.
  • Metaplastic Warthin tumor is a rarely seen subtype of Warthin tumor.
  • Making a diagnosis can become easier by knowing this entity of Warthin tumor well and by correlating the radiologic findings with pathology.
  • In this case presentation, imaging features of a metaplastic Warthin tumor are presented together with its histopathologic findings.
  • When a solid mass with peripheral enhancing cystic-necrotic component and well defined contour and capsule that shows early enhancement and washout is identified with imaging methods in parotid gland, metaplastic Warthin tumor should be indicated in the differential diagnosis before the histopathologic evaluation.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 19969491.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Guntinas-Lichius O, Klussmann JP, Wittekindt C, Stennert E: Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. Laryngoscope; 2006 Apr;116(4):534-40
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  • [Title] Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations.
  • OBJECTIVE/HYPOTHESIS: The objective of this study was to analyze the perioperative and long-term complications after standardized lateral and total parotidectomy for benign parotid tumors and chronic parotitis with special regard on the training skill of the surgeons at a university teaching center.
  • First recurrence for pleomorphic adenoma was observed in 2% and for Warthin's tumor in 3%.
  • CONCLUSIONS: Standardized education in lateral and total parotidectomy for treatment of benign parotid disease under precise microscopic control is safe, demonstrates good results, and has low perioperative and long-term morbidity.

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  • (PMID = 16585855.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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40. Fogarty GB, Mok MT, Taranto A, Murray WK: Warthin's tumour, a rare false positive on positron emission tomography in melanoma staging. Acta Oncol; 2005;44(1):87-9
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  • [Title] Warthin's tumour, a rare false positive on positron emission tomography in melanoma staging.
  • [MeSH-major] Adenolymphoma / radionuclide imaging. Melanoma / radionuclide imaging. Positron-Emission Tomography / methods. Skin Neoplasms / radionuclide imaging

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  • (PMID = 15858864.001).
  • [ISSN] 0284-186X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
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41. Wierzgoń J, Szymczyk C, Maciejewski A, Półtorak S: [Partial parotidectomy--alternative method in surgical management of parotid gland Warthin tumours]. Otolaryngol Pol; 2007;61(2):142-6
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  • [Title] [Partial parotidectomy--alternative method in surgical management of parotid gland Warthin tumours].
  • 82 patients with adenolymphoma of parotid gland treated with surgery in Department of Oncological Surgery Cancer Center, Gliwice in the period of 1986-2004 were retrospectively analyzed.
  • They were about 22% of all patients with parotid gland tumors operated in that period.
  • Local recurrence occurred in less then 5%, only in cases with multiple tumor in histopathological examinations.
  • Partial resection of the parotid gland could be useful method of surgical treatment of adenolymphoma selected cases.
  • In analyzed group the local recurrence was always combined with multi lesional growth of the tumor.
  • [MeSH-major] Adenolymphoma / surgery. Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Facial Nerve / physiopathology. Facial Paralysis / etiology. Facial Paralysis / prevention & control. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Postoperative Complications / mortality. Quality of Life. Retrospective Studies. Surgical Procedures, Operative / methods. Survival Rate. Treatment Outcome

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  • (PMID = 17668799.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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42. Patnayak R, Jena A, Kumar Chowhan A: Role of cell block preparation in Warthin's tumour. Cytopathology; 2010 Dec;21(6):423; author reply 423
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  • [Title] Role of cell block preparation in Warthin's tumour.
  • [MeSH-major] Adenolymphoma / diagnosis. Salivary Gland Neoplasms / diagnosis

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  • [CommentOn] Cytopathology. 2010 Jun;21(3):164-9 [19744189.001]
  • (PMID = 20726866.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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43. Bahar G, Dudkiewicz M, Feinmesser R, Joshua BZ, Braslavsky D, Popovtzer A, Galil D, Shpitzer T: Acute parotitis as a complication of fine-needle aspiration in Warthin's tumor. A unique finding of a 3-year experience with parotid tumor aspiration. Otolaryngol Head Neck Surg; 2006 Apr;134(4):646-9
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  • [Title] Acute parotitis as a complication of fine-needle aspiration in Warthin's tumor. A unique finding of a 3-year experience with parotid tumor aspiration.
  • Some studies suggest that FNA can cause infarction or metaplastic transformation of benign Warthin's tumors.
  • RESULTS: Of the 256 lesions aspirated, 99 patients (39%), were cytologically diagnosed as benign tumors, including 31 (12%) Warthin's tumors, of which 16/17 resected and confirmed histologically.
  • Five patients with Warthin's tumor had post-FNA parotitis and were treated accordingly.
  • CONCLUSIONS: The combination of cystic spaces surrounded by oncocytic cells and a poor blood supply makes the tumor susceptible to infarction and inflammation.
  • Nevertheless, when Warthin's tumor is clinically suspected on the basis of its location (tail of the parotid gland), cystic texture, patient sex (male) and age, one should consider parotitis as a possible complication.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology. Parotitis / etiology
  • [MeSH-minor] Acute Disease. Aged. Aged, 80 and over. Anti-Bacterial Agents / therapeutic use. Biopsy, Fine-Needle / adverse effects. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Risk Factors

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  • (PMID = 16564390.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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44. Giannone N, Lo Muzio L, Politi M: Extracapsular lumpectomy and SMAS flap for benign parotid tumours: an early outcome in a small number of cases on Frey's syndrome and facial nerve dysfunction. J Craniomaxillofac Surg; 2008 Jun;36(4):239-43
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  • None of the patients affected by pleomorphic adenoma or Warthin's tumour had a complete facial palsy.
  • [MeSH-major] Adenolymphoma / surgery. Adenoma, Pleomorphic / surgery. Oral Surgical Procedures / adverse effects. Parotid Neoplasms / surgery. Surgical Flaps

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  • (PMID = 18313936.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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45. Zhang S, Bao R, Bagby J, Abreo F: Fine needle aspiration of salivary glands: 5-year experience from a single academic center. Acta Cytol; 2009 Jul-Aug;53(4):375-82
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  • The only false positive was a pleomorphic adenoma misdiagnosed as adenoid cystic carcinoma.
  • Five benign neoplasms were interpreted as reactive processes, including 2 Warthin's tumors, 2 sebaceous lymphoadenomas and 1 pleomorphic adenoma.

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  • (PMID = 19697720.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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46. Zhang S, Bao R, Abreo F: Papillary oncocytic cystadenoma of the parotid glands: a report of 2 cases with varied cytologic features. Acta Cytol; 2009 Jul-Aug;53(4):445-8
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  • [Title] Papillary oncocytic cystadenoma of the parotid glands: a report of 2 cases with varied cytologic features.
  • BACKGROUND: Papillary cystadenoma is a rare salivary gland neoplasm, and oncocytic change can be focal or marked.
  • Papillary oncocytic cystadenoma has been reported mainly in the minor salivary glands and occasionally in the parotid glands.
  • Oncocytic neoplasm was diagnosed during intraoperative consultation, and final surgical histology showed a unilocular, cystic, oncocytic neoplasm with variable papillary projections.
  • FNA showed less cellular smears with extensive necrotic debris and a few large sheets of epithelial cells with vague papillary architecture.
  • Oncocytic neoplasm was diagnosed during intraoperative consultation, and final surgical histology showed a unilocular cystic lesion with multiple papillary fronds lined with oncocytic cells and focal metaplastic squamous cells.
  • CONCLUSION: Papillary cystadenoma is rare in the parotid glands, and cytologic features may vary.
  • Warthin's tumor, oncocytoma, intraductal papilloma and acinic cell carcinoma may arise in the differential diagnosis.
  • [MeSH-major] Cystadenoma, Papillary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19697734.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Baumhoer D, Pfaltz M, Seydoux J, Jundt G: [Warthin tumor with carcinoma: malignant transformation or metastasis?]. Pathologe; 2009 Nov;30(6):457-60
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  • [Title] [Warthin tumor with carcinoma: malignant transformation or metastasis?].
  • [Transliterated title] Warthin-Tumor mit Karzinom: Maligne Transformation oder Metastase?
  • We present the unusual case of a cytologically diagnosed Warthin tumor (WT) of long standing with sudden enlargement und subsequent resection.
  • Histologically, the diagnosis of WT was confirmed, but the tumor additionally showed diffuse infiltrates of an adenocarcinoma undergoing unrestrained growth.
  • Warthin tumor with malignant transformation was suspected and radiological staging examinations were conducted.
  • Care should always be taken when the diagnosis of malignant WT is made to exclude metastatic disease.
  • [MeSH-major] Adenolymphoma / diagnosis. Adenolymphoma / pathology. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Carcinoma, Lobular / diagnosis. Carcinoma, Lobular / pathology. Carcinoma, Lobular / secondary. Cell Transformation, Neoplastic / pathology. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Parotid Neoplasms / secondary
  • [MeSH-minor] Biomarkers, Tumor / analysis. Breast / pathology. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis / pathology. Middle Aged. Neoplasm Staging. Positron-Emission Tomography

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  • [Cites] Oral Maxillofac Surg. 2009 Mar;13(1):49-53 [19190940.001]
  • [Cites] Virchows Arch. 2005 Jun;446(6):585-8 [15912361.001]
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  • (PMID = 19784653.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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48. Herce-López J, Salazar-Fernández CI, Mayorga-Jiménez F, Gallana-Alvarez S, Pérez-Sánchez JM: Synchronous unilateral parotid neoplasms. A case report. Med Oral Patol Oral Cir Bucal; 2009 Feb;14(2):E90-2
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  • The parotid gland is the most usual location of benign neoplasms affecting major salivary glands and quite often the recurrence of these tumours is noticed, specially in the case of pleomorphic adenoma.
  • The occurrence of multiple tumours in the parotid glands is rare and the majority of these are multifocal Warthin's tumors (papillary cystadenoma lymphomatosum).
  • The simultaneous development of tumours with different histological types is unusual and when it occurs, the most common combination is a pleomorphic adenoma and a Warthin's tumor.
  • There are many articles about Multiple Parotid Tumors (MPT) but only a few of them are focused on unilateral synchronous benings tumors, being pleomorphic adenoma and Warthin's these tumors.
  • The report describes a 55 year old female with a pleomorphic adenoma occurring synchronously with a Warthin's tumor within the superficial lobe of her left parotid gland.
  • [MeSH-major] Adenolymphoma. Adenoma, Pleomorphic. Neoplasms, Multiple Primary. Parotid Neoplasms

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  • (PMID = 19179956.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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49. Gorai S, Numata T, Kawada S, Nakano M, Tamaru J, Kobayashi T: Malignant lymphoma arising from heterotopic Warthin's tumor in the neck: case report and review of the literature. Tohoku J Exp Med; 2007 Jun;212(2):199-205
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  • [Title] Malignant lymphoma arising from heterotopic Warthin's tumor in the neck: case report and review of the literature.
  • Warthin's tumor (WT), so-called adenolymphoma, is a benign salivary gland tumor with both epithelial and lymphoid histological characteristics, so the histogenesis remains unclear.
  • Treatment consists primarily of tumor removal or conservative follow up.
  • Tumor removal or careful follow up is recommended in patients with WT because of the potential risk posed by such malignant transformation.
  • [MeSH-major] Adenolymphoma / pathology. Lymphoma, Large B-Cell, Diffuse / etiology. Neck / pathology

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  • (PMID = 17548964.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79; 0 / B-Cell-Specific Activator Protein; 0 / PAX5 protein, human
  • [Number-of-references] 28
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50. Li LJ, Li Y, Wen YM, Liu H, Zhao HW: Clinical analysis of salivary gland tumor cases in West China in past 50 years. Oral Oncol; 2008 Feb;44(2):187-92
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  • [Title] Clinical analysis of salivary gland tumor cases in West China in past 50 years.
  • In our study, 3461 cases of salivary gland tumor treated between 1955 and 2002 at West China Stomatology Hospital of Sichuan University were retrospectively analyzed, and compared with the previous reports.
  • Measures such as age, tumor location, tumor histological type, and the nature of the growth (benign or malignant) were recorded at the same time.
  • The findings are as follows: the average ages of salivary gland tumor patients were 41.38 years for the benign cases and 45.20 for the malignant ones; the male:female ratio was 0.
  • 99:1 in the benign cases and 1.34:1 in the malignant ones; primary tumors were mostly in the parotid gland, palate and submandibular gland in sequence.
  • Pleomorphic adenoma was the most frequent benign tumor followed by Warthin's tumor and basal cell adenoma, whereas mucoepidermoid carcinoma, adenoid cystic carcinoma and adenocarcinoma not otherwise specified were the most frequent malignant tumors.
  • The incidence of salivary gland tumors increased with age.
  • The male:female ratio of malignant tumors was higher than that of benign ones.
  • The parotid gland and palate were the most common locations of salivary gland tumors.
  • Pleomorphic adenoma and mucoepidermoid carcinoma were the most frequent benign and malignant tumors, respectively.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenolymphoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Child. Child, Preschool. China / epidemiology. Female. Humans. Incidence. Infant. Male. Middle Aged. Palatal Neoplasms / pathology. Parotid Neoplasms / pathology. Retrospective Studies

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  • [ErratumIn] Oral Oncol. 2011 Sep;47(9):929-30
  • (PMID = 17418612.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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51. Steele NP, Sampogna D, Sessions RB: Kaposi's sarcoma of an intraparotid lymph node leading to a diagnosis of HIV. Laryngoscope; 2005 May;115(5):861-3
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  • The patient underwent a right superficial parotidectomy for a suspected diagnosis of Warthin's tumor, given the bilaterality of the lesions.
  • [MeSH-minor] Adenolymphoma / diagnosis. Biopsy, Needle. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged


52. Bell D, Luna MA, Weber RS, Kaye FJ, El-Naggar AK: CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association. Genes Chromosomes Cancer; 2008 Apr;47(4):309-14
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  • [Title] CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association.
  • The t(11;19) translocation and its CRTC1/MAML2 fusion transcript have been identified in several examples of both Warthin's tumor and mucoepidermoid carcinoma and are believed to be associated with the development of a subset of these tumors.
  • To determine whether Warthin's tumor and mucoepidermoid carcinoma are genetically related, we used reverse transcriptase-polymerase chain reaction and DNA sequencing to analyze microdissected components of three tumors consisting of Warthin's tumor and mucoepidermoid carcinoma.
  • We also investigated a metastatic melanoma to Warthin's tumor and a Warthin's carcinoma of the parotid gland for comparison.
  • The fusion transcript was identified in both Warthin's tumor and matching mucoepidermoid carcinoma components of all three tumors, in the Warthin's carcinoma, and in the Warthin's tumor component but not in the metastatic melanoma.
  • The results provide evidence for a link between the t(11;19) fusion gene and the development of a subset of Warthin's tumors with concurrent mucoepidermoid carcinoma and possible malignant transformation to Warthin's carcinoma.
  • [MeSH-major] Adenolymphoma / genetics. Carcinoma, Mucoepidermoid / genetics. DNA-Binding Proteins / genetics. Nuclear Proteins / genetics. Oncogene Proteins, Fusion / genetics. Parotid Neoplasms / genetics. Transcription Factors / genetics

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18181164.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-16672
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / Transcription Factors
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53. Dăguci L, Simionescu C, Dăguci C, Bătăiosu M, Dragomir LP: Clinical and Morphological Aspects of Warthin's Tumor. Curr Health Sci J; 2009 Apr;35(2):115-8
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  • [Title] Clinical and Morphological Aspects of Warthin's Tumor.
  • The study includes 16 cases of Warthin's tumor in a period of 4 years (2004-2008).
  • The tumors were diagnosed at patients of VII decade, most of them smoker.
  • The studies of Warthin's tumor macroscopic morphological parameters allow us to establish the localization exclusive at parotid glands like solitary tumor and the tumoral volume oscillate mostly between 2-4 cm in diameter.
  • Histopathologically we notice the prevalence of typical tumor forms, with balanced raport epithelium / stroma.

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  • (PMID = 24778816.001).
  • [ISSN] 2067-0656
  • [Journal-full-title] Current health sciences journal
  • [ISO-abbreviation] Curr Health Sci J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Other-IDs] NLM/ PMC3945243
  • [Keywords] NOTNLM ; Warthin’s tumor / salivary gland / stroma / tumoral pattern
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54. Winnes M, Enlund F, Mark J, Stenman G: The MECT1-MAML2 gene fusion and benign Warthin's tumor: is the MECT1-MAML2 gene fusion specific to mucuepidermoid carcinoma? J Mol Diagn; 2006 Jul;8(3):394-5; author reply 395-6
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  • [Title] The MECT1-MAML2 gene fusion and benign Warthin's tumor: is the MECT1-MAML2 gene fusion specific to mucuepidermoid carcinoma?
  • [MeSH-major] Adenolymphoma / genetics. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / genetics. Oncogene Proteins, Fusion / genetics
  • [MeSH-minor] Biomarkers, Tumor. Humans. In Situ Hybridization. Sensitivity and Specificity. Translocation, Genetic

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  • (PMID = 16825514.001).
  • [ISSN] 1525-1578
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] eng
  • [Publication-type] Comment; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
  • [Other-IDs] NLM/ PMC1876653
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55. Ozcan C, Apa DD, Aslan G, Gülhan S, Görür K: Mycobacterium tuberculosis infection within parotid gland Warthin tumor. J Craniofac Surg; 2008 Nov;19(6):1561-5
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  • [Title] Mycobacterium tuberculosis infection within parotid gland Warthin tumor.
  • One is a diffuse parenchymatous disease (either primary or secondary to nodal disease), resembling common infection.
  • Warthin tumor is a well-known benign neoplasm of the salivary glands.
  • It is the second most common tumor of the parotid gland.
  • Mycobacterium tuberculosis within Warthin tumor is also unusual.
  • Five cases with parotid gland tuberculosis within Warthin tumor were reported in the literature.
  • In this report, we present a new patient with parotid gland tuberculosis within the Warthin tumor.
  • We also discussed the possible mechanisms of development of infection within Warthin tumor.
  • [MeSH-major] Adenolymphoma / diagnosis. Parotid Diseases / diagnosis. Parotid Neoplasms / diagnosis. Tuberculosis, Oral / diagnosis

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  • (PMID = 19098552.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents; 0 / Contrast Media; 0 / DNA, Bacterial
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56. Liu HX, Sun YM: [Peripheral T-cell lymphoma, NOS arising in Warthin tumor: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2008 Jun;37(6):425
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  • [Title] [Peripheral T-cell lymphoma, NOS arising in Warthin tumor: report of a case].
  • [MeSH-major] Adenolymphoma / enzymology. Lymphoma, T-Cell / enzymology. Lymphoma, T-Cell, Peripheral / enzymology. Nitric Oxide Synthase Type I / metabolism

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  • (PMID = 19031731.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 1.14.13.39 / NOS1 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase Type I
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57. Chen MF, Ueng SH, Jung SM, Chen YL, Chang KP: A type II first branchial cleft cyst masquerading as an infected parotid Warthin's tumor. Chang Gung Med J; 2006 Jul-Aug;29(4):435-9
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  • [Title] A type II first branchial cleft cyst masquerading as an infected parotid Warthin's tumor.
  • We present a case of type II FBCC masquerading as an infected parotid Warthin's tumor.
  • We also review the clinical signs and symptoms of FBCCs in order to remind clinicians that this rare branchial anomaly can mimic an infected Warthin's tumor and may be seated in the deep lobe of the parotid gland.
  • [MeSH-major] Adenolymphoma / diagnosis. Branchioma / diagnosis. Head and Neck Neoplasms / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 17051844.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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58. Yu H, Liu D, Li C, Huang X, Zhong W: [Clinical application of postauricular muscular fasciae-periosteal flap and modified unwrinkle incision in parotidectomy]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2009 Oct;23(10):1167-9
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  • There were 17 males and 11 females aged 19 to 79 years old (average 50 years old), including 20 cases of mixed tumor, 5 cases of adenolymphoma, 1 case of branchial cleft cyst, 1 case of eosinophilic hyperplastic lymphogranuloma, and 1 case of myoepithelioma.
  • Tumor masses were all prominent, with the diameter of 2.4-3.8 cm and partial-tough texture.
  • The course of disease was 3-18 months (average 9.5 months).
  • Parotid gland and tumor mass were resected with postauricular incision hidden within the hairline, introcession defect (3.0 cm x 2.0 cm x 1.0 cm-3.5 cm x 2.5 cm x 1.5 cm) were repaired with simultaneously adopting postauricular muscular fasciae-periosteal flap (4.0 cm x 3.0 cm x 1.0 cm-5.0 cm x 4.0 cm x 1.5 cm) by turning the pedicle flap 180 degrees.

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  • (PMID = 19957830.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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59. de Ru JA, Plantinga RF, Majoor MH, van Benthem PP, Slootweg PJ, Peeters PH, Hordijk GJ: Warthin's tumour and smoking. B-ENT; 2005;1(2):63-6
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  • [Title] Warthin's tumour and smoking.
  • OBJECTIVE: In an evaluation of our patients with parotid gland neoplasms, we noticed that patients with a Warthin's tumour were heavy smokers.
  • The aim of this study was to confirm earlier findings in the literature concerning a possible association between smoking and the development of a Warthin's tumour.
  • METHODS: A case control study was performed using the clinical records and discharge letters of all consecutive patients with a Warthin's tumour in the pathology database of our hospital covering the last 15 years.
  • Patients with a pleomorphic adenoma and a group of patients visiting our audiology department were used as controls.
  • RESULTS: A smoking history was found in 97.5% of the patients with a Warthin's tumour.
  • Of the patients with a pleomorphic adenoma, 59% had a smoking history; 56.5% of the audiology group had a smoking history.
  • Mean age at the time of the operation was 60.1 years of age in the Warthin's tumour group and 48.6 for the pleomorphic adenoma group.
  • CONCLUSION: The mean age for the development of a Warthin's tumour is ten years older than for a pleomorphic adenoma.
  • [MeSH-major] Adenolymphoma / etiology. Parotid Neoplasms / etiology. Smoking / adverse effects
  • [MeSH-minor] Adenoma, Pleomorphic / etiology. Adult. Aged. Case-Control Studies. Female. Humans. Male. Middle Aged. Sex Factors. Time Factors

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  • (PMID = 16044736.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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60. Rössle M, Winter W, Ihrler S: [A rare cause of subacute parotitis. The pathogenetic role of crystals from an infarcted Whartin's tumour?]. HNO; 2005 Nov;53(11):969-72
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  • [Title] [A rare cause of subacute parotitis. The pathogenetic role of crystals from an infarcted Whartin's tumour?].
  • [Transliterated title] Seltene Ursache einer subakuten Parotitis. Pathogenetische Rolle von Kristallen aus infarziertem Warthin-Tumor?
  • The histomorphological examination of the surgical specimen showed an intraglandular area of predominantly chronic histiocytic inflammation with foreign body reaction in the intimate neighbourhood of a small, subtotally infarcted Warthin's tumour.
  • Not birefringent spindle-shaped crystals could be demonstrated both within the parotitis or intraluminally in vital parts of the Warthin's tumour.
  • In terms of the possible causes of the severe intraglandular inflammation, all arguments favour a primary infarction of the Warthin's tumour with the release of intraluminal preformed crystals which secondarily induce a massive inflammation with foreign body reaction, corresponding to the clinical presentation of a subacute parotitis.
  • [MeSH-major] Adenolymphoma / diagnosis. Cholesterol / analysis. Parotid Neoplasms / diagnosis. Parotitis / diagnosis
  • [MeSH-minor] Acute Disease. Crystallization. Diagnosis, Differential. Foreign-Body Reaction / diagnosis. Foreign-Body Reaction / pathology. Foreign-Body Reaction / surgery. Humans. Male. Middle Aged. Parotid Gland / pathology. Parotid Gland / surgery

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  • (PMID = 15580331.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 97C5T2UQ7J / Cholesterol
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66. Freedman LS, Oberman B, Sadetzki S: Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin's tumor risk. Am J Epidemiol; 2009 Nov 1;170(9):1178-85
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  • [Title] Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin's tumor risk.
  • The authors aimed to elucidate the relation of the time-dependent smoking history parameters--age at smoking initiation and smoking intensity, duration, and latency--to the risk of Warthin's tumor, a benign tumor of the salivary gland for which cigarette smoking is a strong risk factor.
  • They studied 117 cases of Warthin's tumor and 336 matched controls included in an Israeli nationwide case-control study of parotid gland tumors conducted from 2002 to 2003 by using the Cox regression model with time-dependent covariates, with age as the time axis.
  • The latter finding implies that the effect of time since cessation dominates the effect of age at initiation, with risk decreasing sharply after smoking cessation.
  • The relation of smoking variables to Warthin's tumor agrees with the patterns reported for lung cancer.
  • [MeSH-major] Adenolymphoma / etiology. Salivary Gland Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 19755633.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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67. Hisatomi M, Asaumi J, Yanagi Y, Unetsubo T, Maki Y, Murakami J, Matsuzaki H, Honda Y, Konouchi H: Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. Oral Oncol; 2007 Oct;43(9):940-7
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  • [Title] Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors.
  • To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in salivary gland tumors, thirty-five patients (47 lesions) who underwent MR examinations and were histopathologically diagnosed with salivary gland tumors in Okayama University Hospital, between April 1998 and March 2005, were entered in the present study.
  • (a) The salivary gland tumors were categorized into three CI curve types according to Tmax and WR300; Pleomorphic adenoma; Tmax > 210 s and WR300 < 10%, Warthin tumor; Tmax < 60 s and WR300 > 40%, and malignant tumor; 60s < Tmax < 210 s and 10% < WR300 < 30%;.
  • (b) On the basis of the relationship between Tmax and CImax or WR, all pleomorphic adenomas were successfully differentiated from Warthin tumor lesions.
  • Of the 20 pleomorphic adenomas, 18 (90.0%) were successfully differentiated from malignant tumors.
  • All Warthin tumor lesions were successfully differentiated from pleomorphic adenomas and malignant tumors.
  • Of 12 the malignant tumors, 11 (91.7%) were successfully differentiated from pleomorphic adenomas.
  • All malignant tumors were successfully differentiated from Warthin tumors.
  • Thus, DCE-MRI parameters are useful in diagnosing salivary gland tumors on the basis of the combined assessment of Tmax and CImax or WR.
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenoma, Pleomorphic / diagnosis. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Parotid Neoplasms / diagnosis. Sensitivity and Specificity

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  • (PMID = 17257881.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; K2I13DR72L / Gadolinium DTPA
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68. Fulciniti F, Losito NS, Ionna F, Longo F, Aversa C, Botti G, Foschini MP: Sclerosing polycystic adenosis of the parotid gland: report of one case diagnosed by fine-needle cytology with in situ malignant transformation. Diagn Cytopathol; 2010 May;38(5):368-73
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  • In line with numerous other pathological analogies between breast and salivary gland lesions, SPA shares with fibrocystic disease of the breast many histopathological features, i.e., fibrosis, oncocytic (apocrine) changes, hyperplasia of ductal and acinar epithelium, cystic dilation of ducts, and, often, atypical epithelial changes.
  • The spectrum of pathological lesions entering differential diagnosis comprised sebaceous adenoma, Warthin's tumors with presence of sebaceous remnants, and low-grade mucoepidermoid carcinoma.

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  • (PMID = 19937766.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Tsakiropoulou E, Konstantinidis I, Vital I, Triaridis S, Vital V: Ectopic Warthin's tumour presenting as a neck mass. B-ENT; 2008;4(2):111-5
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  • [Title] Ectopic Warthin's tumour presenting as a neck mass.
  • INTRODUCTION: Warthin's tumour usually involves the parotid gland.
  • Histological findings of the specimen revealed Warthin's tumour.
  • Coronal and sagittal CT scans are necessary to accurately localize the tumour and to differentiate the diagnosis from earring lesions of the parotid tail.
  • [MeSH-major] Adenolymphoma / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 18681208.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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70. Kara MI, Göze F, Ezirganli S, Polat S, Muderris S, Elagoz S: Neoplasms of the salivary glands in a Turkish adult population. Med Oral Patol Oral Cir Bucal; 2010 Nov;15(6):e880-5
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  • STUDY DESIGN: The histological diagnosis records of the Department of Pathology at Cumhuriyet University were reevaluated for 125 patients who were treated for salivary gland tumors from 1987 to 2008.
  • Pleomorphic adenoma was the most frequent benign tumor followed by Warthin's tumor.
  • CONCLUSIONS: Although there were some discrepancies, the characteristics of salivary gland tumors of Turkish patients are in line with those of patients from other countries according to tumor type, tumor site distribution, and age and sex of patients.

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  • (PMID = 20526249.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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71. Párraga-Linares L, Aguirre-Urízar JM, Berini-Aytés L, Gay-Escoda C: Papillary cystoadenoma lymphomatosum (Warthin-like) of minor salivary glands. Med Oral Patol Oral Cir Bucal; 2009 Nov;14(11):e597-600
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  • [Title] Papillary cystoadenoma lymphomatosum (Warthin-like) of minor salivary glands.
  • Papillary cystadenoma lymphomatosum is a benign salivary gland tumor most frequently located in the parotid gland (Warthin's tumor).
  • Clinically, it manifests as a slow growing tumor, fluctuant on palpation due to its cystic morphology.
  • The treatment of choice is complete excision with wide tumor-free margins.
  • We present a 73-year-old female patient with an asymptomatic tumor of 8 years evolution in the right posterior area of the hard palate.
  • We performed surgical excision and a biopsy, which was reported as papillary cystadenoma lymphomatosum.
  • The lesion was re-operated, performing the excision with CO2 laser and including the periosteum to ensure complete resection of the tumor.
  • [MeSH-major] Adenolymphoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 19680204.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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72. Yuan WH, Hsu HC, Chou YH, Hsueh HC, Tseng TK, Tiu CM: Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands. Clin Imaging; 2009 Sep-Oct;33(5):348-53
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  • [Title] Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands.
  • Our aim was to assess the specific ultrasonic characteristics of pleomorphic adenoma and Warthin's tumor in major salivary glands.
  • METHODS: We retrospectively reviewed and analyzed the ultrasonographic (US) features of 19 pleomorphic adenomas in 16 patients and 29 Warthin's tumors in 20 patients.
  • The features included tumor size, echotexture, boundary, and shape on gray-scale US imaging and grading and distribution of tumor vascularity on color Doppler ultrasound (CDU).
  • Most of the tumors (87.5%) were >or=10 mm, and 93.8% were well defined.
  • Only two of 29 Warthin's tumors had the highest grade of vascularity (+++).
  • Predominantly central blood flow was present in 58.6% of Warthin's tumors and 42.1% of pleomorphic adenomas.
  • Lobulated margin (shape) was noted in 84.2% of pleomorphic adenomas and 51.7% of Warthin's tumors (P<.05).
  • Anechoic cystic components were present in 13 (44.8%) of 29 Warthin's tumors and in only one pleomorphic adenoma (1/19, 5.3%) (P<.01).
  • Internal anechoic cystic components were absent from pleomorphic adenomas but present in some Warthin's tumors.
  • The grading and distribution of blood flow signals on CDU provided only limited additional diagnostic information for distinguishing pleomorphic adenomas from Warthin's tumors.
  • Gray-scale ultrasonography is a useful method for evaluating and distinguishing pleomorphic adenomas from Warthin's tumors.
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Echocardiography, Doppler, Color / methods. Salivary Gland Neoplasms / ultrasonography

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  • (PMID = 19712813.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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73. Sheahan P, Hafidh M, Toner M, Timon C: Unexpected findings in neck dissection for squamous cell carcinoma: incidence and implications. Head Neck; 2005 Jan;27(1):28-35
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  • These pathologic findings may simulate malignant disease and/or have implications on the already complicated management of patients with head and neck cancer.
  • RESULTS: Ten patients had an unexpected finding.
  • These included metastatic papillary thyroid carcinoma, leukemia, lymphoma, Warthin's tumor, and tuberculosis.
  • [MeSH-minor] Adenolymphoma / pathology. Adenolymphoma / therapy. Aged. Aged, 80 and over. Carcinoma, Papillary / pathology. Carcinoma, Papillary / secondary. Carcinoma, Papillary / surgery. Cricoid Cartilage / pathology. Female. Humans. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / therapy. Lymphatic Metastasis. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell / therapy. Male. Middle Aged. Retrospective Studies. Thyroid Neoplasms / pathology. Thyroid Neoplasms / secondary. Thyroid Neoplasms / surgery. Thyroidectomy. Tuberculosis, Lymph Node / drug therapy. Tuberculosis, Lymph Node / pathology


74. Motoori K, Ueda T, Uchida Y, Chazono H, Suzuki H, Ito H: Identification of Warthin tumor: magnetic resonance imaging versus salivary scintigraphy with technetium-99m pertechnetate. J Comput Assist Tomogr; 2005 Jul-Aug;29(4):506-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of Warthin tumor: magnetic resonance imaging versus salivary scintigraphy with technetium-99m pertechnetate.
  • OBJECTIVE: The aim of this study was to evaluate the accuracy of technetium-99m (Tc-99m) pertechnetate scintigraphy and magnetic resonance (MR) imaging in the diagnosis of Warthin tumor.
  • METHODS: Sixteen cases of Warthin tumor and 17 cases of non-Warthin tumor were examined by Tc-99m pertechnetate scintigraphy with lemon juice stimulation and MR imaging, including T1-weighted, T2-weighted, short inversion time inversion recovery, diffusion-weighted, and contrast-enhanced dynamic images.
  • RESULTS: The mean area under the ROC curves of MR imaging in the diagnosis of Warthin tumor (0.97) was higher than that of Tc-99m pertechnetate scintigraphy (0.88).
  • CONCLUSION: Magnetic resonance imaging is more useful in the evaluation of Warthin tumor than Tc-99m pertechnetate scintigraphy.
  • [MeSH-major] Adenolymphoma / pathology. Adenolymphoma / radionuclide imaging. Brain Neoplasms / pathology. Brain Neoplasms / radionuclide imaging. Salivary Glands / radionuclide imaging. Sodium Pertechnetate Tc 99m

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  • (PMID = 16012309.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] A0730CX801 / Sodium Pertechnetate Tc 99m
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75. Masuda A, Nishikawa T, Yamamoto T, Kobayashi M: Distribution of DC-SIGN dendritic cells in the lymphoid stroma of Warthin's tumour; immunohistochemical analysis. Histopathology; 2006 Oct;49(4):433-5
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  • [Title] Distribution of DC-SIGN dendritic cells in the lymphoid stroma of Warthin's tumour; immunohistochemical analysis.
  • [MeSH-major] Adenolymphoma / metabolism. Cell Adhesion Molecules / metabolism. Dendritic Cells / metabolism. Lectins, C-Type / metabolism. Receptors, Cell Surface / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 16978211.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / DC-specific ICAM-3 grabbing nonintegrin; 0 / Lectins, C-Type; 0 / Receptors, Cell Surface
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76. Basu S, Houseni M, Alavi A: Significance of incidental fluorodeoxyglucose uptake in the parotid glands and its impact on patient management. Nucl Med Commun; 2008 Apr;29(4):367-73
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  • In addition, we also examined patients in whom there was no documented evidence of parotid pathology before FDG-PET scan and a suspicion of disease involvement was first raised in the reports in view of focal uptake in the FDG-PET images.
  • Only those cases with no earlier history of disease involvement of parotid gland or known parotid pathology before FDG-PET were selected for this analysis.
  • These patients were selected from a population of patients with a known malignancy elsewhere who underwent conventional whole-body FDG-PET or PET/CT for staging, disease viability assessment, or treatment monitoring purposes and had demonstrated varying patterns of FDG uptake (unilateral, bilateral, symmetric, or asymmetric) in the parotid glands.
  • In five patients with asymmetric and focally enhanced FDG uptake, a suspicion of disease involvement was raised in the reports.
  • No revelation of disease either by the MRI or follow-up clinical and FDG-PET examinations was observed in patients with asymmetric diffuse uptake.
  • The final diagnosis based upon histopathology revealed primary parotid tumors (e.g., Warthin's tumor and pleomorphic adenoma, which presented as FDG-avid parotid incidentaloma) or metastatic disease involvement.
  • An asymmetrical uptake, especially when focal, would warrant further radiological and histopathological correlation to rule out disease involvement.
  • At times, this can lead to the detection of an asymptomatic hitherto unknown etiology, which would have been otherwise interpreted as a metastatic disease in the background of an existing malignancy in these patients; this is noteworthy as it may have a bearing on the subsequent management of these patients.

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  • (PMID = 18317302.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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77. Ethunandan M, Pratt CA, Higgins B, Morrison A, Umar T, Macpherson DW, Wilson AW: Factors influencing the occurrence of multicentric and 'recurrent' Warthin's tumour: a cross sectional study. Int J Oral Maxillofac Surg; 2008 Sep;37(9):831-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors influencing the occurrence of multicentric and 'recurrent' Warthin's tumour: a cross sectional study.
  • The multicentric nature of Warthin's tumour has been well recognised, though the factors predicting its occurrence and its influence on management remain speculative.
  • In this cross sectional study, the authors analysed the presentation, management and outcome of solitary and multicentric Warthin's tumour, treated in the maxillofacial unit and investigated factors that could influence the occurrence of multicentric and recurrent tumours.
  • Warthin's tumour was found in 24% (150/628) of patients presenting with parotid neoplasms and multicentric tumours were found in 13% (21/ 161) of parotidectomy specimens.
  • The recurrence rate was 0% in the solitary and 10% in the multicentric tumour group.
  • Intra-operative rupture was not uncommon (11%), but was not associated with tumour recurrence (P= or >0.999).
  • [MeSH-major] Adenolymphoma / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18550337.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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78. Pastore A, Carinci F, Pelucchi S: Genetic expression profiling of parotid neoplasms by cDNA microarrays. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):153-60
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  • Samples were derived from 5 patients with pleomorphic adenoma, 4 with Warthin's tumour, one with clear cell carcinoma, and 2 with mucoepidermoid carcinoma.
  • Benign Warthin's tumour and pleomorphic adenoma showed very distinctive gene expression patterns.
  • A total of 133 genes differentiated the single malignant clear cell carcinoma from non-tumour salivary glands (p < 0.01), whereas only 16 genes separated it from the highly related benign pleomorphic adenoma (p < 0.01).
  • The results show gene expression alterations common to all tumours and unique to each benign and malignant tumour.
  • The numerous Expressed Sequence Tags of unknown function we identified could also become useful as tumour markers and represent a set of novel tumour-associated genes.

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  • (PMID = 16450770.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639868
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79. Roy S, Dhingra KK, Gupta P, Khurana N, Gupta B, Meher R: Acinic cell carcinoma with extensive neuroendocrine differentiation: a diagnostic challenge. Head Neck Pathol; 2009 Jun;3(2):163-8
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  • Amongst the various reported primary tumors with neuroendocrine differentiation, acinic cell carcinoma (ACC) one such tumor.
  • Contrast Enhanced Computed Tomography (CECT) suggested diagnosis of Pleomorphic Adenoma.
  • Fine Needle Aspiration Cytology (FANC) yielded a cystic fluid suggesting a possibility of Warthin's tumor or Oncocytic lesion.
  • Intraoperative findings were suggestive of a Warthin's tumor.
  • Initial histopathological examination of the tumor was suggestive of neuroendocrine carcinoma.
  • The possibility of neuroendocrine differentiation in a primary salivary gland tumor should be kept in mind whenever a salivary gland tumor shows only neuroendocrine histology.
  • [MeSH-minor] Adenolymphoma / pathology. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 19644544.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Acinic cell / Carcinoma / Chromogranin / Neuroendocrine / Parotid / Warthin’s
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80. Röser K, Jäkel KT, Bullerdiek J, Löning T: [Significance of molecular-cytogenetic findings in mucoepidermoid carcinoma as an example of salivary gland tumors]. Pathologe; 2005 Sep;26(5):359-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Significance of molecular-cytogenetic findings in mucoepidermoid carcinoma as an example of salivary gland tumors].
  • Chromosome translocations in tumors frequently give rise to fusion genes encoding proteins with oncogenic activities.
  • Mucoepidermoid carcinomas (MEC) are characterized by a t(11;19)(q21-22;p13) translocation found in approximately 60% of the tumors.
  • Pending the elucidation of the t(11;19) at the molecular level of an apparently identical chromosomal translocation in Warthin's tumor, the identification of the translocation in MEC by FISH- and/or RT-PCR-analyses may become important in diagnosis and might have prognostic relevance.
  • Warthin's tumors are benign salivary gland neoplasms with a distinctive histomorphology and histogenesis completely different from MEC.

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  • (PMID = 16075259.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
  • [Number-of-references] 27
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81. Srivastava S, Nadelman C: Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. Diagn Cytopathol; 2010 Jul;38(7):533-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature.
  • Fine-needle aspiration (FNA) is a cost effective and low morbidity procedure in the initial assessment of salivary gland tumors.
  • However, cytological assessment of ipsilateral synchronous tumors (which make up less than 0.3% of all salivary gland neoplasms) may pose diagnostic challenges.
  • Here, we report a unique case of Warthin tumor encased by a separate high-grade mucoepidermoid carcinoma that was first diagnosed on FNA.
  • Traditionally, there has been diagnostic difficulty when dealing with synchronous tumors of the salivary gland and the background of chronic sialadenitis may further complicate the diagnosis.
  • [MeSH-major] Adenolymphoma / complications. Adenolymphoma / pathology. Carcinoma, Mucoepidermoid / complications. Carcinoma, Mucoepidermoid / pathology. Parotid Gland / pathology. Parotid Neoplasms / complications. Parotid Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 20027619.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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82. Dalpa E, Gourvas V, Baritaki S, Miyakis S, Samaras V, Barbatis C, Sourvinos G, Spandidos DA: High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland. J Clin Virol; 2008 Jun;42(2):182-5
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  • [Title] High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland.
  • BACKGROUND: Warthin's tumor is a common benign neoplasm of the salivary gland.
  • OBJECTIVES: To provide insights into the HHV-8 cell tropism, the presence of HHV-8 was investigated in a series of Warthin's tumors of the salivary gland and corresponding adjacent normal tissue.
  • STUDY DESIGN: Forty-three patients with Warthin's tumors (cystadenolymphoma) were tested for the presence of HHV-8 DNA, and corresponding adjacent normal tissue samples were obtained from 15 patients.
  • RESULTS: HHV-8 DNA was detected in 19 out of 43 (44%) salivary gland tumor samples.
  • Among the 15 cases with paired samples, 9 were HHV-8-positive for both samples, 4 were HHV-8-negative for both samples while in two cases HHV-8 was detected only in the tumor specimens.
  • CONCLUSIONS: HHV-8 is frequently detected in adenoid salivary neoplasms, suggesting a significant role of the virus in the etiopathogenesis of the disease.
  • Larger studies are required to investigate the role of HHV-8 in the development or progression of Warthin's tumors.
  • [MeSH-major] Adenolymphoma / virology. Herpesvirus 8, Human / isolation & purification. Salivary Gland Neoplasms / virology. Salivary Glands / virology

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  • (PMID = 18339579.001).
  • [ISSN] 1386-6532
  • [Journal-full-title] Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • [ISO-abbreviation] J. Clin. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Viral
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83. Linecker A, Kermer C, Sulzbacher I, Angelberger P, Kletter K, Dudczak R, Ewers R, Becherer A: Uptake of (18)F-FLT and (18)F-FDG in primary head and neck cancer correlates with survival. Nuklearmedizin; 2008;47(2):80-5; quiz N12
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  • Tumour tracer uptake was determined by standardized uptake value (SUV) normalized to body weight and /non-tumor ratios (T/N). (18)F-FDG and (18)F-FLT uptake were compared with histopathologic and immunohistochemical results.
  • RESULTS: 19 patients had malignant tumours; one patient had a benign cystadenoma (so called Warthin's tumour) of the parotid gland.
  • One negative lesion turned out to be a malignant T1 stage squamous cell carcinoma in both PET scans, the Warthin's tumour was false positive with (18)F-FDG but showed only faint uptake with (18)F-FLT, resulting in a sensitivity of 95 % for both tracers.

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  • (PMID = 18392317.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Dideoxynucleosides; 0 / Fluorine Radioisotopes; 0 / Radioisotopes; 0Z5B2CJX4D / Fluorodeoxyglucose F18; PG53R0DWDQ / alovudine
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84. Varshavskiĭ AI: [Clinics, diagnostics and treatment of parotid salivary gland adenomas]. Stomatologiia (Mosk); 2010;89(3):41-4
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  • Pleomorphic adenoma (PA) was found in 81.3% of PGA cases, adenolymphoma (Warthin's tumor) - in 13%, canalicular adenoma - in 2.8%, other adenomas - in 2.9% of observations.
  • PA more often was met in women, adenolymphoma - in men.
  • 2 cases of myoepithelioma and cystadenoma of parotid gland were described.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / surgery. Parotid Neoplasms / diagnosis. Parotid Neoplasms / surgery

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  • (PMID = 20559235.001).
  • [ISSN] 0039-1735
  • [Journal-full-title] Stomatologii︠a︡
  • [ISO-abbreviation] Stomatologiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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85. Suwała P, Wilczyński K, Barnaś S, Prudlak E: [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma]. Otolaryngol Pol; 2009 Sep;63(7):89-92
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  • AIM OF THE WORK: The authors present unusually rare case primary multiple synchronicus benign tumor of the ipsilateral parotid gland: oncocytoma and Warthin's tumor, which is rare among occasionally occurred multiple tumors with different histology in the salivary glands.
  • MATERIAL AND METHOD: A 71-year-old man presented with the tumor in the right parotid gland.
  • The preoperative ultrasonography and macroscopic analysis of the removed parotid gland tissue revealed only one tumor recognised histopathologically as adenolimphoma, but upon histopathological examination Warthin's tumor proved to coexist with oncocytoma.
  • RESULTS AND CONCLUSIONS: In the ultrasonography examination some salivary glands tumors may not be recognised.
  • The histopathological examination is the ultimate method in recognising tumors, which are not detected in the preoperative diagnosis.
  • The superficial parotidectomy protects from the recrudescence of the superficial lobe of the parotid gland tumors.
  • The coexistence of the oncocytoma and Warthin's in one parotid gland is extremely rare.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Oxyphilic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 20564910.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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86. Teymoortash A, Werner JA: Tissue that has lost its track: Warthin's tumour. Virchows Arch; 2005 Jun;446(6):585-8
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  • [Title] Tissue that has lost its track: Warthin's tumour.
  • The origin of cystadenolymphoma (Warthin's tumour) of the parotid gland is unknown.
  • According to the most favoured hypothesis, Warthin's tumour results from the proliferation of salivary gland ductal cells that were entrapped in parotid lymph nodes during embryonal life.
  • If this is correct, and the almost total lack of recurrence and malignant transformation of this lesion lends credence to this view, Warthin's tumour is correctly classified in the group of tumour-like lesions and should not be considered to be a monomorphic adenoma.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology

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  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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87. Ozawa N, Okamura T, Koyama K, Nakayama K, Kawabe J, Shiomi S, Yamane H, Inoue Y: Retrospective review: usefulness of a number of imaging modalities including CT, MRI, technetium-99m pertechnetate scintigraphy, gallium-67 scintigraphy and F-18-FDG PET in the differentiation of benign from malignant parotid masses. Radiat Med; 2006 Jan;24(1):41-9
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  • RESULTS: All of the benign tumors had smooth margins on CT and MRI.
  • All Warthin's tumors showed high technetium accumulation.
  • Many of malignant tumors showed high FDG accumulation.
  • Both pleomorphic adenomas and Warthin's tumors showed high accumulation in some cases on 18F-FDG PET.
  • Among 15 patients with pleomorphic adenoma, 14 patients showed marked hyperintensity relative to CSF on T2-weighted images and partial enhancement on contrast-enhanced T1-weighted images.

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  • (PMID = 16715661.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Gallium Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; A0730CX801 / Sodium Pertechnetate Tc 99m
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88. Uğuz MZ, Onal HK, Eroğlu OO, Etit D: [Sensitivity and specificity of fine needle aspiration biopsy in parotid masses]. Kulak Burun Bogaz Ihtis Derg; 2007;17(2):96-9
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  • The most common histopathological diagnosis was pleomorphic adenoma (n=7, 24.1%), followed by mucoepidermoid carcinoma (n=4, 13.8%), and Warthin's tumor (n=3, 10.3%).
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenolymphoma / pathology. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 17527061.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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89. Teymoortash A, Krasnewicz Y, Werner JA: Clinical features of cystadenolymphoma (Warthin's tumor) of the parotid gland: a retrospective comparative study of 96 cases. Oral Oncol; 2006 Jul;42(6):569-73
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  • [Title] Clinical features of cystadenolymphoma (Warthin's tumor) of the parotid gland: a retrospective comparative study of 96 cases.
  • The details of the etiopathogenesis of cystadenolymphoma (Warthin's tumor) are still unclear.
  • To explore the possible risk factors for the development of this tumor, medical records of 81 patients with 96 Warthin's tumors of the parotid glands were compared retrospectively with those of 91 patients with pleomorphic adenoma.
  • The medical history and clinical tumor characteristics of all patients were similar.
  • However, a significant male predominance of patients with Warthin's tumor could be noted (P<0.05).
  • The male to female ratio was 3.3:1 in patients with Warthin's tumor.
  • Multifocal Warthin's tumor were detected in five cases (6.2%), and 10 patients (12.3%) had bilateral lesions.
  • The odds ratio for the incidence of Warthin's tumor among current smokers compared with never smokers was 8.3 (P<0.0001).
  • Compared with never smokers, clearly higher odds of Warthin's tumor was observed in heavy smokers (more than 30 pack-years) (odds ratio=24.1, P<0.0001) than patients who smoked less than 30 pack-years (odds ratio=4.9, P<0.0001).
  • [MeSH-major] Adenolymphoma / etiology. Adenoma, Pleomorphic / etiology. Parotid Neoplasms / etiology

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  • (PMID = 16469528.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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90. Lee YY, Wong KT, King AD, Ahuja AT: Imaging of salivary gland tumours. Eur J Radiol; 2008 Jun;66(3):419-36
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  • Salivary gland neoplasms account for <3% of all tumors.
  • As a general rule, the smaller the involved salivary gland, the higher is the possibility of the tumor being malignant.
  • The role of imaging in assessment of salivary gland tumour is to define intra-glandular vs. extra-glandular location, detect malignant features, assess local extension and invasion, detect nodal metastases and systemic involvement.
  • If deep tissue extension is suspected or malignancy confirmed on cytology, an MRI or CT is mandatory to evaluate tumour extent, local invasion and perineural spread.
  • Recent study suggests that MR spectroscopy may differentiate malignant and benign salivary gland tumours as well as distinguishing Warthin's tumor from pleomorphic adenoma.
  • Sialography is used to delineate the salivary ductal system and has limited role in assessment of tumour extent.

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  • (PMID = 18337041.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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91. Smith SL, Komisar A: Limited parotidectomy: the role of extracapsular dissection in parotid gland neoplasms. Laryngoscope; 2007 Jul;117(7):1163-7
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  • OBJECTIVE: Surgical techniques for parotid gland neoplasm removal have been shaped over the years by the importance of the gland's relationship with the facial nerve, histologic behavior of parotid tumors, and recurrence rates from specific techniques.
  • RESULTS: All tumors were located in the superficial lobe of the parotid gland and size of the masses ranged from 4.0 to 1.0 cm (mean 2.4 cm) in diameter.
  • Pathology of the parotid tumors consisted of 11 pleomorphic adenomas, six Warthin's tumors, six benign epithelial cysts, one sarcoid lesion, two lymphoid hyperplasia, and one Kaposi's sarcoma.

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  • [CommentIn] Laryngoscope. 2008 Feb;118(2):379; author reply 379-80 [18303396.001]
  • (PMID = 17632913.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Al Salamah SM, Khalid K, Khan IA, Gul R: Outcome of surgery for parotid tumours: 5-year experience of a general surgical unit in a teaching hospital. ANZ J Surg; 2005 Nov;75(11):948-52
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  • Pleomorphic adenoma was the commonest pathology observed in 24 patients (64.9%).
  • Warthin's tumour was more common among male patients and was the only pathology with bilateral involvement.
  • Malignant tumour was found in five patients (13.5%).
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Biopsy, Fine-Needle. Facial Nerve Diseases / etiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postoperative Complications. Prospective Studies. Treatment Outcome

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  • (PMID = 16336383.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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93. Foschini MP, Gaiba A, Cocchi R, Pennesi MG, Pession A: p63 expression in salivary gland tumors: role of DeltaNp73L in neoplastic transformation. Int J Surg Pathol; 2005 Oct;13(4):329-35
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  • [Title] p63 expression in salivary gland tumors: role of DeltaNp73L in neoplastic transformation.
  • To illustrate the role of p63 and its truncated variants in salivary gland tumors, 23 consecutive tumors and 6 normal salivary glands were studied immunohistochemically with anti-p63 antibody and by reverse transcriptase (RT) and nested polymerase chain reaction (PCR) to detect p63 isoform expression.
  • Tumors: p63 antibody was positive in the following: Warthin tumor (WT) (3/3), oncocytoma (OC) (1/1), pleomorphic adenoma (PA) (7/7), polymorphous-low-grade adenocarcinoma (PLGA) (3/3), adenoid-cystic carcinoma (ADCC)(3/4), epithelial-myoepithelial-cell carcinoma (EMC) (1/1), and myoepithelial-cell carcinoma (MCC) (1/1).
  • By RT and nested PCR all tumors expressed p63 irrespective of their morphologic differentiation.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenolymphoma / metabolism. Adenolymphoma / pathology. Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Adult. Aged. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cell Proliferation. DNA-Binding Proteins. Exons. Female. Gene Expression Regulation, Neoplastic. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Male. Middle Aged. Myoepithelioma / metabolism. Myoepithelioma / pathology. Polymerase Chain Reaction. Protein Isoforms. Reverse Transcriptase Polymerase Chain Reaction. Salivary Glands / cytology. Salivary Glands / metabolism. Salivary Glands / pathology. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 16273188.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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94. Silva SJ, Costa Junior GT, Brant Filho AC, Faria PR, Loyola AM: Metachronous bilateral pleomorphic adenoma of the parotid gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Mar;101(3):333-8
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  • [Title] Metachronous bilateral pleomorphic adenoma of the parotid gland.
  • Bilateral salivary gland tumors are very rare, accounting for 3% of all parotid gland tumors.
  • Although the most common tumor with bilateral development is the Warthin tumor, pleomorphic adenomas (PA) have been diagnosed simultaneously as well, but in a smaller incidence.
  • A total and superficial parotidectomy for left and right tumors, respectively, was performed.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16504867.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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95. Gürbüz Y, Yildiz K, Aydin O, Almaç A: Immunophenotypical profiles of salivary gland tumours: a new evidence for their histogenetic origin. Pathologica; 2006 Apr;98(2):147-52
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  • 30 cases of salivary gland tumours (18 pleomorphic adenomas, 8 Warthin's tumours, 2 basal cell adenomas, 2 acinic cell carcinomas) were included in our study.
  • SMA was not detected in Warthin's tumour (p < 0.0001).
  • CK10 immunoreactivity was observed in 5 Warthin's tumour.
  • Immunophenotypic profile of Warthin's tumour is suggestive of an embryological remnant origin.
  • [MeSH-minor] Adenolymphoma / chemistry. Adenolymphoma / pathology. Adenoma / chemistry. Adenoma / pathology. Adenoma, Pleomorphic / chemistry. Adenoma, Pleomorphic / pathology. Carcinoma, Acinar Cell / chemistry. Carcinoma, Acinar Cell / pathology. Humans. Immunophenotyping. Organ Specificity. Protein Isoforms / analysis. Retrospective Studies

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  • (PMID = 16929788.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Actins; 0 / Neoplasm Proteins; 0 / Protein Isoforms; 68238-35-7 / Keratins
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96. Pietniczka-Załeska M, Kukwa A: [The parotid gland's tumours in material of Otolaryngology Department Medical Academy in Warsaw in 1990-2006]. Otolaryngol Pol; 2008;62(4):395-9
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  • The most frequent tumours were pleomorphic adenoma and adenolymphoma.
  • (1) There were 81% cases of benign neoplasm and 19% malignant neoplasm in presented material. (2) The result of parotid gland treatment depends on tumor's histopathology, the period of disease, the size of tumour, its expansion into the neighbourhood, infiltrating of the facial nerve and metastases into the lymph nodes. (3) Radical resection of tumour and metastases, reconstructing the continuity of tissues and maintaining the quality of patients life, should be the principle of surgical treatment.

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  • (PMID = 18837210.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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97. Ito FA, Ito K, Coletta RD, Vargas PA, Lopes MA: Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors. Braz Oral Res; 2009 Oct-Dec;23(4):393-8
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  • [Title] Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors.
  • The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands.
  • A total of 41 pleomorphic adenomas, 30 Warthin's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed.
  • Androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma.
  • In conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas.
  • However, androgen receptors can play a role in a small set of salivary gland tumors, and this would deserve further studies.

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  • (PMID = 20027446.001).
  • [ISSN] 1807-3107
  • [Journal-full-title] Brazilian oral research
  • [ISO-abbreviation] Braz Oral Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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98. Alibek S, Zenk J, Bozzato A, Lell M, Grunewald M, Anders K, Rabe C, Iro H, Bautz W, Greess H: The value of dynamic MRI studies in parotid tumors. Acad Radiol; 2007 Jun;14(6):701-10
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  • [Title] The value of dynamic MRI studies in parotid tumors.
  • RATIONALE AND OBJECTIVES: To evaluate the ability of dynamic contrast-enhanced magnetic resonance imaging (MRI) to differentiate several tumor entities of the parotid gland in a prospective clinical trial.
  • MATERIALS AND METHODS: A total of 112 patients with parotid tumors were examined with dynamic contrast-enhanced 1.5 T MRI.
  • Signal intensity versus time (SIvT) curves was obtained for all tumors.
  • Finally, all MRIs together with the tumor specific SIvT curves were re-read and correlated with histopathologic diagnosis.
  • RESULTS: Four characteristic intensity-time curves were observed: pleomorphic adenoma showed a gradual increase in signal intensity, followed by a plateau phase on a low intensity level.
  • Adenolymphomas as well as carcinomas showed a rapid increase in signal intensity followed by a plateau phase.
  • Statistic significance was found for the time-to-peak values for adenolymphomas and pleomorphic adenomas and for the maximum peak signal intensity values for carcinomas.
  • Together with other morphologic MRI criteria (contrast enhancement, border characteristics) and clinical features, a differentiation between adenolymphoma and carcinoma was possible.
  • CONCLUSIONS: With additional dynamic contrast-enhanced MRI, a more reliable differentiation between common parotid tumors is possible before surgery.
  • [MeSH-major] Adenolymphoma / diagnosis. Adenoma, Pleomorphic / diagnosis. Carcinoma / diagnosis. Magnetic Resonance Imaging / methods. Parotid Gland / pathology. Parotid Neoplasms / diagnosis

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  • (PMID = 17502260.001).
  • [ISSN] 1076-6332
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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99. Yaor MA: The pattern of presentation of salivary gland tumors in Africa: A review of published reports. Ear Nose Throat J; 2010 Feb;89(2):E17-21
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  • [Title] The pattern of presentation of salivary gland tumors in Africa: A review of published reports.
  • Salivary glands are the site of a wide variety of histopathologic types of benign and malignant tumors.
  • The author reviewed 23 articles from 12 African countries published between 1980 and 2004 to examine patterns of salivary gland tumors.
  • Also, there may be a female preponderance in Africa, and Warthin tumor is rare.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / pathology

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  • (PMID = 20155665.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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100. Ellis GL: Lymphoid lesions of salivary glands: malignant and benign. Med Oral Patol Oral Cir Bucal; 2007 Dec;12(7):E479-85
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  • Lymphoepithelial sialadenitis, HIV-associated salivary gland disease, chronic sclerosing sialadenitis, Warthin tumor, and extranodal marginal zone B-cell lymphoma are examples of this pathology that are sometimes problematic to differentiate from one another.
  • [MeSH-minor] Adenolymphoma / diagnosis. Carcinoma / diagnosis. Humans. Lymphoma, B-Cell, Marginal Zone / diagnosis. Prognosis. Sialadenitis / diagnosis

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  • (PMID = 17978770.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 30
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