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1. Abd-Elhamid ES, Elshafei MM: Immunohistochemical localization of mdm-2, p27Kip1 and bcl-2 in Warthin's tumor of the parotid gland. Diagn Pathol; 2009;4:14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical localization of mdm-2, p27Kip1 and bcl-2 in Warthin's tumor of the parotid gland.
  • BACKGROUND: Warthin's tumor is a benign monomorphic adenoma with unclear origin that almost occur exclusively in the parotid gland.
  • Etiology of Warthin's tumor as well as its malignant potential are still unclear.
  • Therefore immunohistochemical assessment of Warthin's tumor may be useful to detect its origin or its malignant transformation potential.
  • AIMS AND OBJECTIVES: The present study aims to investigate the immunohistochemical expression of murine double minute-2 (mdm-2), p27Kip1 and B cell lymphoma-2 (bcl-2) in Warthin's tumor of parotid gland and also to clarify the role of these proteins in the behavior of that tumor.
  • METHODS: Twenty paraffin blocks of cases previously diagnosed as Warthin's tumor were collected for immunohistochemical staining with primary antibodies against mdm-2, p27Kip1 and bcl-2 using streptavidin-biotin immunoperoxidase staining system.
  • CONCLUSION: Mdm-2 played a tumor-suppressor role that might be implicated with the benign behavior of Warthin's tumor.

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  • (PMID = 19445705.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2693442
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2. Dăguci L, Simionescu C, Dăguci C, Bătăiosu M, Dragomir LP: Clinical and Morphological Aspects of Warthin's Tumor. Curr Health Sci J; 2009 Apr;35(2):115-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and Morphological Aspects of Warthin's Tumor.
  • The study includes 16 cases of Warthin's tumor in a period of 4 years (2004-2008).
  • The studies of Warthin's tumor macroscopic morphological parameters allow us to establish the localization exclusive at parotid glands like solitary tumor and the tumoral volume oscillate mostly between 2-4 cm in diameter.
  • Histopathologically we notice the prevalence of typical tumor forms, with balanced raport epithelium / stroma.

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  • (PMID = 24778816.001).
  • [ISSN] 2067-0656
  • [Journal-full-title] Current health sciences journal
  • [ISO-abbreviation] Curr Health Sci J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Other-IDs] NLM/ PMC3945243
  • [Keywords] NOTNLM ; Warthin’s tumor / salivary gland / stroma / tumoral pattern
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3. Fodor D, Pop S, Maniu A, Cosgaria M: Gray scale and Doppler ultrasonography of the benign tumors of parotid gland (pleomorphic adenoma and Warthin's tumor). Pictorial essay. Med Ultrason; 2010 Sep;12(3):238-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gray scale and Doppler ultrasonography of the benign tumors of parotid gland (pleomorphic adenoma and Warthin's tumor). Pictorial essay.
  • The purpose of this pictorial essay is to illustrate the ultrasonographic aspects of the most common benign tumors of the parotid gland: pleomorphic adenoma and Warthin's tumor.
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Parotid Neoplasms / ultrasonography. Ultrasonography, Doppler

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  • (PMID = 21203603.001).
  • [ISSN] 1844-4172
  • [Journal-full-title] Medical ultrasonography
  • [ISO-abbreviation] Med Ultrason
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
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4. Berrocal Postigo E, Galera Ruiz H, Ruiz Clemente J, González García J, Muñoz Borge F: [Ectopic Warthin's tumour in nasopharynx. Revision of one clinical case]. Acta Otorrinolaringol Esp; 2005 Aug-Sep;56(7):328-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ectopic Warthin's tumour in nasopharynx. Revision of one clinical case].
  • [Transliterated title] Tumor de warthin ectópico en la nasofaringe. A propósito de un caso clínico.
  • A CT scan is informed as a well delimited and rounded-shaped tumour compatible with lymphoma.
  • Excisional biopsy by a nasal rigid endoscopy is practiced and the histology result is Warthin's tumour.
  • [MeSH-major] Adenolymphoma / pathology. Adenolymphoma / radiography. Choristoma / pathology. Choristoma / radiography. Nasopharyngeal Neoplasms / pathology. Nasopharyngeal Neoplasms / radiography. Nasopharynx

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  • (PMID = 16240924.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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5. Song K, Cotelingam JD, Lowery-Nordberg M, Sun W: Characterization of the lymphoid stroma in Warthin's tumor of salivary gland by immunohistochemistry, heavy chain gene and Bcl-2 gene rearrangement. Am J Transl Res; 2009;1(4):352-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of the lymphoid stroma in Warthin's tumor of salivary gland by immunohistochemistry, heavy chain gene and Bcl-2 gene rearrangement.
  • Warthin's tumor is rarely associated with malignant lymphoma.
  • In most cases the latter is a low grade process, including Marginal zone/Mucosa associated lymphoid tissue (MALT) type lymphoma, follicular lymphoma, and rarely diffuse large cell lymphoma which may arise de novo or secondary to low grade lymphoma.
  • This study was conducted to determine the prevalence of occult B cell monoclones and genetic alterations in Warthin's tumor.
  • Fourteen cases of Warthin's tumor were stained with antibodies to CD3, CD20, kappa and lambda light chains.
  • On six cases of randomly selected Warthin's tumor, polymerase chain reaction (PCR) of IgH gene rearrangement (IgH-GR) was performed on genomic DNA extracted from formalin-fixed paraffin embedded tissue.
  • One case of primary salivary gland indolent B-cell lymphoma and 3 cases of sialadenitis were analyzed by the same methods for comparison.
  • In all Warthin's tumor and sialadenitis cases most of lymphoid stroma was B cell phenotype and concentrated in germinal centers.
  • Our study concludes that the lymphoid stroma of Warthin's tumor is reactive.

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  • (PMID = 19956447.001).
  • [ISSN] 1943-8141
  • [Journal-full-title] American journal of translational research
  • [ISO-abbreviation] Am J Transl Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780035
  • [Keywords] NOTNLM ; Warthin's tumor / gene rearrangement / immunohistochemistry / lymphoid stroma
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6. Chen MF, Ueng SH, Jung SM, Chen YL, Chang KP: A type II first branchial cleft cyst masquerading as an infected parotid Warthin's tumor. Chang Gung Med J; 2006 Jul-Aug;29(4):435-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A type II first branchial cleft cyst masquerading as an infected parotid Warthin's tumor.
  • The diagnosis of a parotid mass usually depends on thorough history taking and physical examination.
  • First branchial cleft cysts (FBCCs) are rare causes of parotid swelling and comprise less than 1% of all branchial anomalies.
  • We present a case of type II FBCC masquerading as an infected parotid Warthin's tumor.
  • We also review the clinical signs and symptoms of FBCCs in order to remind clinicians that this rare branchial anomaly can mimic an infected Warthin's tumor and may be seated in the deep lobe of the parotid gland.
  • [MeSH-major] Adenolymphoma / diagnosis. Branchioma / diagnosis. Head and Neck Neoplasms / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 17051844.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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7. Wierzgoń J, Szymczyk C, Maciejewski A, Półtorak S: [Partial parotidectomy--alternative method in surgical management of parotid gland Warthin tumours]. Otolaryngol Pol; 2007;61(2):142-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Partial parotidectomy--alternative method in surgical management of parotid gland Warthin tumours].
  • 82 patients with adenolymphoma of parotid gland treated with surgery in Department of Oncological Surgery Cancer Center, Gliwice in the period of 1986-2004 were retrospectively analyzed.
  • They were about 22% of all patients with parotid gland tumors operated in that period.
  • Local recurrence occurred in less then 5%, only in cases with multiple tumor in histopathological examinations.
  • Partial resection of the parotid gland could be useful method of surgical treatment of adenolymphoma selected cases.
  • In analyzed group the local recurrence was always combined with multi lesional growth of the tumor.
  • [MeSH-major] Adenolymphoma / surgery. Parotid Neoplasms / surgery

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  • (PMID = 17668799.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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8. de Ru JA, Plantinga RF, Majoor MH, van Benthem PP, Slootweg PJ, Peeters PH, Hordijk GJ: Warthin's tumour and smoking. B-ENT; 2005;1(2):63-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Warthin's tumour and smoking.
  • OBJECTIVE: In an evaluation of our patients with parotid gland neoplasms, we noticed that patients with a Warthin's tumour were heavy smokers.
  • The aim of this study was to confirm earlier findings in the literature concerning a possible association between smoking and the development of a Warthin's tumour.
  • METHODS: A case control study was performed using the clinical records and discharge letters of all consecutive patients with a Warthin's tumour in the pathology database of our hospital covering the last 15 years.
  • RESULTS: A smoking history was found in 97.5% of the patients with a Warthin's tumour.
  • Mean age at the time of the operation was 60.1 years of age in the Warthin's tumour group and 48.6 for the pleomorphic adenoma group.
  • CONCLUSION: The mean age for the development of a Warthin's tumour is ten years older than for a pleomorphic adenoma.
  • [MeSH-major] Adenolymphoma / etiology. Parotid Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 16044736.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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9. Mardi K, Sharma J: Mucoepidermoid carcinoma arising in Warthin's tumor: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):331-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucoepidermoid carcinoma arising in Warthin's tumor: a case report.
  • Malignant transformation of the epithelial component of Warthin's tumor is extremely rare.
  • We describe our experience of mucoepidermoid carcinoma arising in Warthin's tumor of the parotid gland in a 35 year old female.
  • The tumor removed from the parotid region was well encapsulated and histologically comprised ofmucoepidermoid carcinoma along with areas of Warthin's tumor.
  • [MeSH-major] Adenolymphoma / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Second Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17883061.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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10. Teymoortash A, Schrader C, Shimoda H, Kato S, Werner JA: Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland. Oral Oncol; 2007 Jul;43(6):614-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland.
  • The details of the pathogenesis of cystadenolymphoma (Warthin's tumor) of the parotid gland are still unclear.
  • Neovascularization is considered to be a pivotal factor for solid tumor progression and biological behavior of the tumor.
  • Using double-labeling immunohistochemistry for LYVE-1 and CD34 (specific markers for lymphatic and vascular endothelial cells, respectively) this study analyzes lymphatic vessel density (LVD) and blood vessel density (BVD) in 10 Warthin's tumors and 10 pleomorphic adenomas of the parotid gland as well as in 5 normal parotid glands and 5 normal parotid lymph nodes.
  • There was no significant difference in the intratumoral LVD and BVD among pleomorphic adenoma and normal parotid gland tissue.
  • In contrast, the intratumoral LVD and BVD were significantly higher in Warthin's tumor than pleomorphic adenoma, normal parotid gland and parotid lymph node (P<0.0001 versus P<0.004).
  • The increase in lymphatic vessels in Warthin's tumor suggests that epithelial tumor cells might promote lymphangiogenesis in this kind of lesions.
  • [MeSH-major] Adenolymphoma / pathology. Lymphangiogenesis. Parotid Neoplasms / pathology

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  • (PMID = 16996778.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / LYVE1 protein, human; 0 / Vesicular Transport Proteins
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11. Iwai H, Yamashita T: Local excision procedure for Warthin's tumor of the parotid gland. Otolaryngol Head Neck Surg; 2005 Apr;132(4):577-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Local excision procedure for Warthin's tumor of the parotid gland.
  • The aim of this work is to establish a local excision procedure (LEP) and indications of this procedure for Warthin's tumor.
  • Seventy-three patients (82 sides) with Warthin's tumor were studied.
  • For Warthin's tumor estimated to be below the I-S line (Group A), LEP was used, involving resection of the tumor after locating and dissecting the marginal mandibular and colli branches.
  • Conversely, no significant difference in tumor size or incidence of postoperative facial paresis was identified between the 2 groups.
  • In conclusion, LEP is useful for Warthin's tumor below the I-S line.
  • This procedure seems applicable not only to Warthin's tumors, but also to other benign parotid tumors in the surgical field below the I-S line, such as pleomorphic adenoma and lymphoepithelial cyst.
  • [MeSH-major] Adenolymphoma / surgery. Microsurgery / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 15806048.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Iwai H, Yamashita T: [Surgical procedure for Warthin's tumor in the parotid gland]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Jun;108(6):679-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical procedure for Warthin's tumor in the parotid gland].
  • Warthin's tumor is benign and exclusively involves the parotid gland but may, however, often show multifocal and/or bilateral growth.
  • The aim of this study was to evaluate the surgical procedure for removal of this tumor.
  • Sixty patients with Warthin's tumor in the parotid gland who presented at the Kansai Medical University Hospital from 1990 to 1999 were the subjects of the present study.
  • Tumors in the superficial lobe were resected with partial parotidectomy, and an enucleative procedure was also performed at the bottom of the tumor where the tumor capsule directly touched the facial nerve.
  • Therefore, we recommend that enucleation is a useful choice as a surgical procedure for the removal of Warthin's tumor after accurate detection of the tumors using MRI.
  • These findings indicate that more careful consideration for preservation of the facial nerve should be given in such cases and that simultaneous surgery for such tumors in the bilateral parotid glands should be avoided to prevent bilateral facial nerve palsy.
  • [MeSH-major] Adenolymphoma / surgery. Otorhinolaryngologic Surgical Procedures / methods. Parotid Neoplasms / surgery

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  • (PMID = 16001725.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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13. Freedman LS, Oberman B, Sadetzki S: Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin's tumor risk. Am J Epidemiol; 2009 Nov 1;170(9):1178-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin's tumor risk.
  • The authors aimed to elucidate the relation of the time-dependent smoking history parameters--age at smoking initiation and smoking intensity, duration, and latency--to the risk of Warthin's tumor, a benign tumor of the salivary gland for which cigarette smoking is a strong risk factor.
  • They studied 117 cases of Warthin's tumor and 336 matched controls included in an Israeli nationwide case-control study of parotid gland tumors conducted from 2002 to 2003 by using the Cox regression model with time-dependent covariates, with age as the time axis.
  • The relation of smoking variables to Warthin's tumor agrees with the patterns reported for lung cancer.
  • [MeSH-major] Adenolymphoma / etiology. Salivary Gland Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 19755633.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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14. Teymoortash A, Werner JA: Tissue that has lost its track: Warthin's tumour. Virchows Arch; 2005 Jun;446(6):585-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tissue that has lost its track: Warthin's tumour.
  • The origin of cystadenolymphoma (Warthin's tumour) of the parotid gland is unknown.
  • According to the most favoured hypothesis, Warthin's tumour results from the proliferation of salivary gland ductal cells that were entrapped in parotid lymph nodes during embryonal life.
  • If this is correct, and the almost total lack of recurrence and malignant transformation of this lesion lends credence to this view, Warthin's tumour is correctly classified in the group of tumour-like lesions and should not be considered to be a monomorphic adenoma.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology

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  • [CommentIn] Virchows Arch. 2006 Jun;448(6):877-8 [16609912.001]
  • (PMID = 15912361.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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15. Bell D, Luna MA, Weber RS, Kaye FJ, El-Naggar AK: CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association. Genes Chromosomes Cancer; 2008 Apr;47(4):309-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association.
  • The t(11;19) translocation and its CRTC1/MAML2 fusion transcript have been identified in several examples of both Warthin's tumor and mucoepidermoid carcinoma and are believed to be associated with the development of a subset of these tumors.
  • To determine whether Warthin's tumor and mucoepidermoid carcinoma are genetically related, we used reverse transcriptase-polymerase chain reaction and DNA sequencing to analyze microdissected components of three tumors consisting of Warthin's tumor and mucoepidermoid carcinoma.
  • We also investigated a metastatic melanoma to Warthin's tumor and a Warthin's carcinoma of the parotid gland for comparison.
  • The fusion transcript was identified in both Warthin's tumor and matching mucoepidermoid carcinoma components of all three tumors, in the Warthin's carcinoma, and in the Warthin's tumor component but not in the metastatic melanoma.
  • The results provide evidence for a link between the t(11;19) fusion gene and the development of a subset of Warthin's tumors with concurrent mucoepidermoid carcinoma and possible malignant transformation to Warthin's carcinoma.
  • [MeSH-major] Adenolymphoma / genetics. Carcinoma, Mucoepidermoid / genetics. DNA-Binding Proteins / genetics. Nuclear Proteins / genetics. Oncogene Proteins, Fusion / genetics. Parotid Neoplasms / genetics. Transcription Factors / genetics

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18181164.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-16672
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / Transcription Factors
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16. Teymoortash A, Krasnewicz Y, Werner JA: Clinical features of cystadenolymphoma (Warthin's tumor) of the parotid gland: a retrospective comparative study of 96 cases. Oral Oncol; 2006 Jul;42(6):569-73
Genetic Alliance. consumer health - Warthin's tumor.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical features of cystadenolymphoma (Warthin's tumor) of the parotid gland: a retrospective comparative study of 96 cases.
  • The details of the etiopathogenesis of cystadenolymphoma (Warthin's tumor) are still unclear.
  • To explore the possible risk factors for the development of this tumor, medical records of 81 patients with 96 Warthin's tumors of the parotid glands were compared retrospectively with those of 91 patients with pleomorphic adenoma.
  • The medical history and clinical tumor characteristics of all patients were similar.
  • However, a significant male predominance of patients with Warthin's tumor could be noted (P<0.05).
  • The male to female ratio was 3.3:1 in patients with Warthin's tumor.
  • Multifocal Warthin's tumor were detected in five cases (6.2%), and 10 patients (12.3%) had bilateral lesions.
  • The odds ratio for the incidence of Warthin's tumor among current smokers compared with never smokers was 8.3 (P<0.0001).
  • Compared with never smokers, clearly higher odds of Warthin's tumor was observed in heavy smokers (more than 30 pack-years) (odds ratio=24.1, P<0.0001) than patients who smoked less than 30 pack-years (odds ratio=4.9, P<0.0001).
  • [MeSH-major] Adenolymphoma / etiology. Adenoma, Pleomorphic / etiology. Parotid Neoplasms / etiology

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  • (PMID = 16469528.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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17. Andreadis D, Epivatianos A, Poulopoulos A, Nomikos A, Christidis K, Papazoglou G, Antoniades D, Barbatis C: Immunohistochemical detection of the expression of the cell adhesion molecules E-cadherin, desmoglein-2, beta4-integrin, ICAM-1 and HCAM (CD44s) in Warthin's tumour of the parotid gland. Oral Oncol; 2005 Sep;41(8):799-805
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical detection of the expression of the cell adhesion molecules E-cadherin, desmoglein-2, beta4-integrin, ICAM-1 and HCAM (CD44s) in Warthin's tumour of the parotid gland.
  • The study of the expression of cell adhesion molecules (CAMs), E-cadherin, desmoglein-2, beta4-integrin, HCAM (CD44s) and ICAM-1 in Warthin's tumours.
  • Twenty formalin--fixed, paraffin--embedded parotid Warthin's tumours were studied using an Envision/HRP immunohistochemical technique.
  • CAM expression suggests a bilayered excretory ductal structure of the neoplastic epithelium in Warthin's tumour, as a result of hyperplastic process of the glandular epithelium that interacts with the excessive lymphoid tissue of the stroma.
  • [MeSH-major] Adenolymphoma / metabolism. Cell Adhesion Molecules / metabolism. Integrin beta4 / metabolism. Neoplasm Proteins / metabolism. Parotid Neoplasms / metabolism

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  • (PMID = 16043382.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Cell Adhesion Molecules; 0 / Desmoglein 2; 0 / Integrin beta4; 0 / Neoplasm Proteins
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18. Moore FO, Abdel-Misih RZ, Berne JD, Zieske AW, Rana NR, Ryckman JG: Poorly differentiated carcinoma arising in a Warthin's tumor of the parotid gland: pathogenesis, histopathology, and surgical management of malignant Warthin's tumors. Am Surg; 2007 Apr;73(4):397-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Poorly differentiated carcinoma arising in a Warthin's tumor of the parotid gland: pathogenesis, histopathology, and surgical management of malignant Warthin's tumors.
  • Warthin's tumor is a benign lymphoepithelial neoplasm representing 10 per cent of all parotid gland tumors.
  • Malignant transformation of a Warthin's tumor is an extremely rare event.
  • We report a case of a patient with poorly differentiated carcinoma arising from a Warthin's tumor, as well as review the pathogenesis, histopathology, and surgical management of malignant Warthin's tumors.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17439037.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Loy AH, Putti TC, Tan LK: Cyclooxygenase-2 expression in Warthin's tumour. J Laryngol Otol; 2005 Jul;119(7):515-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclooxygenase-2 expression in Warthin's tumour.
  • OBJECTIVES: To determine whether cyclooxygenase-2 (COX-2) is overexpressed in Warthin's tumours, and to characterize its pattern of expression.
  • METHODS: Twenty-one paraffin-embedded Warthin's tumour specimens were analysed by immunohistochemical staining for expression of human COX-2.
  • There was also overexpression of COX-2 in the salivary duct system of normal parotid tissue.
  • CONCLUSIONS: Our results suggest that COX-2 is up-regulated in the epithelial component of Warthin's tumours.
  • Our findings support the hypothesis that Warthin's tumours originate from heterotopic ductal epithelial cells of the parotid gland.
  • The role of COX-2 expression in the pathogenesis of Warthin's tumours remains to be determined.
  • [MeSH-major] Adenolymphoma / enzymology. Cyclooxygenase 2 / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Epithelium / enzymology. Humans. Immunohistochemistry / methods. Lymphoid Tissue / enzymology. Male. Middle Aged. Parotid Gland / enzymology. Salivary Ducts / enzymology

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  • (PMID = 16175974.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2
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20. O'Neill ID: New insights into the nature of Warthin's tumour. J Oral Pathol Med; 2009 Jan;38(1):145-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New insights into the nature of Warthin's tumour.
  • Warthin's tumour is considered heterogeneous as to its pathogenesis with some data supporting a polyclonal origin for the epithelium, implying a non-neoplastic nature.
  • After inconsistent reports, current information from molecular studies suggests that a recurrent t(11;19) and associated CRTC1-MAML2 fusion oncogene characterizes a subset of Warthin's tumours and supports a clonal origin in such cases.
  • These findings, and the recent reports of Warthin's tumour and co-existent mucoepidermoid carcinoma with common CRTC1-MAML2 expression, provide a morphological and molecular framework for future studies as a basis for a fresh appraisal of the pathogenesis of Warthin's tumour.
  • [MeSH-major] Adenolymphoma / genetics. Oncogene Fusion / genetics. Salivary Gland Neoplasms / genetics. Translocation, Genetic / genetics

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  • (PMID = 18647217.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CRCT1 protein, human; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Proteins; 0 / Transcription Factors
  • [Number-of-references] 44
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21. Barabás J, Bogdán S, Suba Z, Szabó G, Lukáts O, Decker I, Huszár T: [Parotid gland Warthin's tumor combined with actinomycosis]. Orv Hetil; 2006 Apr 30;147(17):807-10
Genetic Alliance. consumer health - Warthin's tumor.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Parotid gland Warthin's tumor combined with actinomycosis].
  • [Transliterated title] Actinomycosissal kombinált, parotisban elhelyezkedo Warthin-tumor ritka esete.
  • The authors describe the diagnostic problems and difficulties of treatment of Warthin's tumor combined with actinomycosis.
  • A 48-year-old woman was presented with a mass in the left parotid region and paresis of the lower left palpebra.
  • The CT, echography, parotid X-ray findings supposed a neoplasm of the left parotid gland which was proved by intraoperative freezing histology.
  • The final histological evaluation was Warthin's tumor with actinomycosis.
  • [MeSH-major] Actinomycosis. Adenolymphoma. Parotid Neoplasms

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  • (PMID = 16780189.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 74469-00-4 / Amoxicillin-Potassium Clavulanate Combination
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22. Jung SM, Hao SP: Warthin's tumor with multiple granulomas: a clinicopathologic study of six cases. Diagn Cytopathol; 2006 Aug;34(8):564-7
Genetic Alliance. consumer health - Warthin's tumor.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Warthin's tumor with multiple granulomas: a clinicopathologic study of six cases.
  • Granulomatous inflammation occurring in Warthin's tumor is a rare phenomenon.
  • We studied cases of Warthin's tumor with granulomatous inflammation to analyze the possible relationship with prior FNA.
  • Granulomatous inflammation was noted in 6 cases (1.6%) of 382 cases of Warthin's tumor in a medical center.
  • All 6 cases showed typical features of Warthin's tumor accompanied by multiple granulomas.
  • There were 2 cases with history of preoperative FNA; both already had granulomas in Warthin's tumor in cytologic specimens taken by aspiration.
  • The pathogenesis of granulomatous inflammation in Warthin's tumor remains speculative.
  • [MeSH-major] Adenolymphoma / etiology. Adenolymphoma / pathology. Granuloma / etiology. Parotid Neoplasms / etiology

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16850483.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Becelli R, Morello R, Renzi G, Dominici C: Warthin's tumor of the hard palate. J Craniofac Surg; 2007 Sep;18(5):1182-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Warthin's tumor of the hard palate.
  • Warthin's Tumor (WT) or papillary cystadenoma lymphomatosum is typically located in parotid gland.
  • Extraparotid localization of WTs (EPWT) was rarely described in ectopic salivary tissue in the latero-cervical and para-parotid lymph nodes.
  • [MeSH-major] Adenolymphoma / pathology. Palatal Neoplasms / pathology. Palate, Hard / pathology

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  • (PMID = 17912110.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Giaslakiotis K, Androulaki A, Panagoulias G, Kyrtsonis MC, Lazaris AC, Kanakis DN, Patsouris ES: T cell lymphoblastic lymphoma in parotidectomy for Warthin's tumor: case report and review of the literature. Int J Hematol; 2009 Apr;89(3):359-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] T cell lymphoblastic lymphoma in parotidectomy for Warthin's tumor: case report and review of the literature.
  • Lymphomas associated with Warthin's tumor (WT) are extremely uncommon and the majorities are of B cell type.
  • We report the simultaneous occurrence of T-cell lymphoblastic lymphoma (T-LBL) and WT in an 81-year-old patient, who presented with fever, night sweats and enlargement of the right parotid gland.
  • [MeSH-major] Adenolymphoma / pathology. Adenolymphoma / surgery. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell / surgery. Parathyroidectomy. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery

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  • (PMID = 19294485.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD
  • [Number-of-references] 19
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25. Bahar G, Dudkiewicz M, Feinmesser R, Joshua BZ, Braslavsky D, Popovtzer A, Galil D, Shpitzer T: Acute parotitis as a complication of fine-needle aspiration in Warthin's tumor. A unique finding of a 3-year experience with parotid tumor aspiration. Otolaryngol Head Neck Surg; 2006 Apr;134(4):646-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute parotitis as a complication of fine-needle aspiration in Warthin's tumor. A unique finding of a 3-year experience with parotid tumor aspiration.
  • OBJECTIVE/HYPOTHESIS: Fine needle aspiration (FNA) is an accurate, cost-effective tool for the study of salivary gland lesions.
  • Although complications are extremely rare, salivary gland FNA can lead to hemorrhage, facial nerve injury, and cellulitis at the needle puncture site.
  • Some studies suggest that FNA can cause infarction or metaplastic transformation of benign Warthin's tumors.
  • We review our recent experience with FNA of the parotid gland, focusing on possible complications and pitfalls.
  • STUDY DESIGN AND SETTING: The medical records of all patients who underwent FNA of the parotid gland from 2000 to 2002 in the Department of Otolaryngology-Head and Neck Surgery of a major tertiary-care referral center were reviewed.
  • RESULTS: Of the 256 lesions aspirated, 99 patients (39%), were cytologically diagnosed as benign tumors, including 31 (12%) Warthin's tumors, of which 16/17 resected and confirmed histologically.
  • Five patients with Warthin's tumor had post-FNA parotitis and were treated accordingly.
  • CONCLUSIONS: The combination of cystic spaces surrounded by oncocytic cells and a poor blood supply makes the tumor susceptible to infarction and inflammation.
  • Nevertheless, when Warthin's tumor is clinically suspected on the basis of its location (tail of the parotid gland), cystic texture, patient sex (male) and age, one should consider parotitis as a possible complication.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology. Parotitis / etiology

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  • (PMID = 16564390.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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26. Shaw CK, Sood S, Bradley PJ, Krishnan S: Unusual mass in the parapharyngeal space: a Warthin's tumour. ANZ J Surg; 2006 Mar;76(3):193-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual mass in the parapharyngeal space: a Warthin's tumour.
  • Most of the PPS tumours are salivary tumours (pleomorphic adenoma being the most frequent diagnosis), and are thought to originate from minor salivary glands or the deep lobe of the parotid gland.
  • Warthin's tumour, another benign salivary tumour involving the PPS has been rarely reported.
  • A case of bilateral, metachronous Warthin's tumour involving the PPS is reported here.
  • PPS Warthin's tumour is a very rare condition that if undiagnosed may result in considerable morbidity.
  • [MeSH-major] Adenolymphoma / pathology. Neoplasms, Second Primary / pathology. Parotid Neoplasms / pathology. Pharynx / pathology
  • [MeSH-minor] Aged. Female. Humans. Neoplasm Invasiveness. Parotid Gland / surgery. Tomography, X-Ray Computed

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  • (PMID = 16626365.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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27. Kawata R, Yoshimura K, Lee K, Araki M, Takenaka H, Tsuji M: Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases--basal cell adenoma versus pleomorphic adenoma and Warthin's tumor. Eur Arch Otorhinolaryngol; 2010 May;267(5):779-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases--basal cell adenoma versus pleomorphic adenoma and Warthin's tumor.
  • The aim of this study is to investigate the clinical and pathological characteristics of basal cell adenoma (BCA) and to compare the diagnosis/treatment of BCA with those of Warthin's tumor (WT) and pleomorphic adenoma (PA).
  • Among 192 patients with benign tumors of the parotid gland who underwent surgery, 9 had BCA.
  • Most PA and BCA lesions developed in the upper part of the parotid gland.
  • Considering the gender difference, tumor site, and age, it is necessary to differentiate BCA from PA rather than from WT.
  • BCA is the third most common of the benign parotid tumors, following WT and PA, although its incidence is low.
  • When PA and WT are ruled out by FNAB after a tentative diagnosis of benign tumor has been based on imaging findings, BCA should be considered.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma / pathology. Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19908055.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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28. Terada T: Hyperplastic intraparotid lymph nodes with incipient Warthin's tumor presenting as a parotid tumor. Pathol Res Pract; 2008;204(11):863-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyperplastic intraparotid lymph nodes with incipient Warthin's tumor presenting as a parotid tumor.
  • Reactive follicular hyperplasia of the intraparotid lymph nodes (IPLs) forming a parotid tumor has rarely been reported, and the pathogenesis of Warthin's tumor has not been determined.
  • A case of hyperplastic IPLs with incipient Warthin's tumors presenting as a parotid tumor is presented.
  • A 68-year-old Japanese patient presented with a tumor of the right parotid gland, and the tumor was resected.
  • Very small foci of Warthin's tumor were recognized in two of the IPLs.
  • Immunohistochemical studies showed that the oncocytes of the small Warthin's tumor and the ductular elements were positive for cytokeratin, but negative for carcinoembryonic antigen, vimentin, alpha-smooth muscle antigen, and S100 protein.
  • The present case suggests that reactive hyperplastic IPLs may form a parotid tumor, and that Warthin's tumor may develop in hyperplastic IPLs at the inception of its tumorigenesis.
  • [MeSH-major] Adenolymphoma / pathology. Lymph Nodes / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18572328.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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29. Yuan WH, Hsu HC, Chou YH, Hsueh HC, Tseng TK, Tiu CM: Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands. Clin Imaging; 2009 Sep-Oct;33(5):348-53
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands.
  • Our aim was to assess the specific ultrasonic characteristics of pleomorphic adenoma and Warthin's tumor in major salivary glands.
  • METHODS: We retrospectively reviewed and analyzed the ultrasonographic (US) features of 19 pleomorphic adenomas in 16 patients and 29 Warthin's tumors in 20 patients.
  • The features included tumor size, echotexture, boundary, and shape on gray-scale US imaging and grading and distribution of tumor vascularity on color Doppler ultrasound (CDU).
  • Only two of 29 Warthin's tumors had the highest grade of vascularity (+++).
  • Predominantly central blood flow was present in 58.6% of Warthin's tumors and 42.1% of pleomorphic adenomas.
  • Lobulated margin (shape) was noted in 84.2% of pleomorphic adenomas and 51.7% of Warthin's tumors (P<.05).
  • Anechoic cystic components were present in 13 (44.8%) of 29 Warthin's tumors and in only one pleomorphic adenoma (1/19, 5.3%) (P<.01).
  • Internal anechoic cystic components were absent from pleomorphic adenomas but present in some Warthin's tumors.
  • The grading and distribution of blood flow signals on CDU provided only limited additional diagnostic information for distinguishing pleomorphic adenomas from Warthin's tumors.
  • Gray-scale ultrasonography is a useful method for evaluating and distinguishing pleomorphic adenomas from Warthin's tumors.
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Echocardiography, Doppler, Color / methods. Salivary Gland Neoplasms / ultrasonography

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  • (PMID = 19712813.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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30. Viguer JM, Vicandi B, Jiménez-Heffernan JA, López-Ferrer P, González-Peramato P, Castillo C: Role of fine needle aspiration cytology in the diagnosis and management of Warthin's tumour of the salivary glands. Cytopathology; 2010 Jun;21(3):164-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of fine needle aspiration cytology in the diagnosis and management of Warthin's tumour of the salivary glands.
  • OBJECTIVE: Local excision surgical procedures and non-surgical conservative management are considered alternatives to superficial parotidectomy in the treatment and management of Warthin's tumour (WT).
  • One tumour diagnosed as WT was a low-grade mucoepidermoid carcinoma.
  • Cytology, when coupled with clinical and image findings, may permit conservative tumour management.
  • [MeSH-major] Adenolymphoma / diagnosis. Adenolymphoma / therapy. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / therapy. Salivary Glands / pathology

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  • [CommentIn] Cytopathology. 2010 Dec;21(6):423; author reply 423 [20726866.001]
  • (PMID = 19744189.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Cobb CJ, Greaves TS, Raza AS: Fine needle aspiration cytology and diagnostic pitfalls in Warthin's tumor with necrotizing granulomatous inflammation and facial nerve paralysis: a case report. Acta Cytol; 2009 Jul-Aug;53(4):431-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytology and diagnostic pitfalls in Warthin's tumor with necrotizing granulomatous inflammation and facial nerve paralysis: a case report.
  • BACKGROUND: Warthin's tumor can be associated with various secondary changes that challenge both clinical and cytologic diagnosis.
  • CASE: A 44-year-old man presented with a Warthin's tumor (WT) that was associated with multiple secondary changes.
  • The right parotid mass was present and mostly asymptomatic for 6 years, but during the 7th year, there was pain and ipsilateral facial nerve dysfunction following abrupt increase in size of the mass.
  • [MeSH-major] Adenolymphoma / pathology. Facial Paralysis / etiology. Parotid Neoplasms / pathology

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  • (PMID = 19697730.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Cardoso SV, do Nascimento Souza KC, de Faria PR, Lima RA, Nascimento MF, Eisenberg AL, Dias FL, Loyola AM: Warthin's tumor at the Brazilian National Cancer Institute: additional evidence of homogeneous sex prevalence and association with other neoplasms. ORL J Otorhinolaryngol Relat Spec; 2008;70(6):339-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Warthin's tumor at the Brazilian National Cancer Institute: additional evidence of homogeneous sex prevalence and association with other neoplasms.
  • PURPOSE OF THE STUDY: To report the largest Brazilian series of Warthin's tumor (WT).
  • Parotid lesions were prevalent, but there were patients with lesions in cervical lymph nodes and in the inferior lip.
  • [MeSH-major] Adenolymphoma / epidemiology. Adenolymphoma / surgery. Lymph Nodes / pathology. Neoplasm Recurrence, Local / epidemiology. Parotid Neoplasms / epidemiology. Parotid Neoplasms / surgery

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18984968.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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33. Gorai S, Numata T, Kawada S, Nakano M, Tamaru J, Kobayashi T: Malignant lymphoma arising from heterotopic Warthin's tumor in the neck: case report and review of the literature. Tohoku J Exp Med; 2007 Jun;212(2):199-205
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant lymphoma arising from heterotopic Warthin's tumor in the neck: case report and review of the literature.
  • Warthin's tumor (WT), so-called adenolymphoma, is a benign salivary gland tumor with both epithelial and lymphoid histological characteristics, so the histogenesis remains unclear.
  • Treatment consists primarily of tumor removal or conservative follow up.
  • Tumor removal or careful follow up is recommended in patients with WT because of the potential risk posed by such malignant transformation.
  • [MeSH-major] Adenolymphoma / pathology. Lymphoma, Large B-Cell, Diffuse / etiology. Neck / pathology

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  • (PMID = 17548964.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79; 0 / B-Cell-Specific Activator Protein; 0 / PAX5 protein, human
  • [Number-of-references] 28
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34. Ethunandan M, Pratt CA, Higgins B, Morrison A, Umar T, Macpherson DW, Wilson AW: Factors influencing the occurrence of multicentric and 'recurrent' Warthin's tumour: a cross sectional study. Int J Oral Maxillofac Surg; 2008 Sep;37(9):831-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors influencing the occurrence of multicentric and 'recurrent' Warthin's tumour: a cross sectional study.
  • The multicentric nature of Warthin's tumour has been well recognised, though the factors predicting its occurrence and its influence on management remain speculative.
  • In this cross sectional study, the authors analysed the presentation, management and outcome of solitary and multicentric Warthin's tumour, treated in the maxillofacial unit and investigated factors that could influence the occurrence of multicentric and recurrent tumours.
  • Warthin's tumour was found in 24% (150/628) of patients presenting with parotid neoplasms and multicentric tumours were found in 13% (21/ 161) of parotidectomy specimens.
  • The recurrence rate was 0% in the solitary and 10% in the multicentric tumour group.
  • Intra-operative rupture was not uncommon (11%), but was not associated with tumour recurrence (P= or >0.999).
  • [MeSH-major] Adenolymphoma / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18550337.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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35. Taylor TR, Cozens NJ, Robinson I: Warthin's tumour: a retrospective case series. Br J Radiol; 2009 Nov;82(983):916-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Warthin's tumour: a retrospective case series.
  • Warthin's tumour (benign cystadenolymphoma) is the second most common salivary gland tumour after pleomorphic salivary adenoma, and it is commonly encountered in routine head and neck ultrasonography.
  • We describe 7 cases of radiologically infarcting Warthin's tumours in situ in a retrospective analysis of 76 patients, and demonstrate an approximate incidence of at least 9% of infarction following fine-needle aspiration in lesions left in situ.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19433486.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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36. Tsakiropoulou E, Konstantinidis I, Vital I, Triaridis S, Vital V: Ectopic Warthin's tumour presenting as a neck mass. B-ENT; 2008;4(2):111-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic Warthin's tumour presenting as a neck mass.
  • INTRODUCTION: Warthin's tumour usually involves the parotid gland.
  • However, it can also arise from ectopic salivary tissue in the para-parotid and latero-cervical lymph nodes.
  • Histological findings of the specimen revealed Warthin's tumour.
  • Coronal and sagittal CT scans are necessary to accurately localize the tumour and to differentiate the diagnosis from earring lesions of the parotid tail.
  • [MeSH-major] Adenolymphoma / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 18681208.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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37. Rössle M, Winter W, Ihrler S: [A rare cause of subacute parotitis. The pathogenetic role of crystals from an infarcted Whartin's tumour?]. HNO; 2005 Nov;53(11):969-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A rare cause of subacute parotitis. The pathogenetic role of crystals from an infarcted Whartin's tumour?].
  • [Transliterated title] Seltene Ursache einer subakuten Parotitis. Pathogenetische Rolle von Kristallen aus infarziertem Warthin-Tumor?
  • The etiology of a subacute inflammatory swelling in the area of the right parotid gland in a 62-years old man could not be resolved clinically.
  • The histomorphological examination of the surgical specimen showed an intraglandular area of predominantly chronic histiocytic inflammation with foreign body reaction in the intimate neighbourhood of a small, subtotally infarcted Warthin's tumour.
  • Not birefringent spindle-shaped crystals could be demonstrated both within the parotitis or intraluminally in vital parts of the Warthin's tumour.
  • In terms of the possible causes of the severe intraglandular inflammation, all arguments favour a primary infarction of the Warthin's tumour with the release of intraluminal preformed crystals which secondarily induce a massive inflammation with foreign body reaction, corresponding to the clinical presentation of a subacute parotitis.
  • [MeSH-major] Adenolymphoma / diagnosis. Cholesterol / analysis. Parotid Neoplasms / diagnosis. Parotitis / diagnosis
  • [MeSH-minor] Acute Disease. Crystallization. Diagnosis, Differential. Foreign-Body Reaction / diagnosis. Foreign-Body Reaction / pathology. Foreign-Body Reaction / surgery. Humans. Male. Middle Aged. Parotid Gland / pathology. Parotid Gland / surgery

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  • [Cites] Cytopathology. 1999 Aug;10(4):276-9 [10458505.001]
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  • (PMID = 15580331.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 97C5T2UQ7J / Cholesterol
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38. Colella G, Biondi P, Itro A, Compilato D, Campisi G: Warthin's tumor distribution within the parotid gland. A feasible etiologic source from lymph nodal tissue. Minerva Stomatol; 2010 May;59(5):245-9, 250-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Warthin's tumor distribution within the parotid gland. A feasible etiologic source from lymph nodal tissue.
  • AIM: Warthin's tumor (WT) is the second commonest parotid gland neoplasm after pleomorphic adenoma (PA).
  • It mainly arises from the lower pole of the superficial parotid lobe (i.e., tail of gland), a site with the greatest distribution of intra-parotid lymph nodes, and its definitive etiopathogenesis is still unclear.
  • The aim of this study was to support the strict topic and etiologic link hypothesised between this tumor and the intraparotid lymph nodes, as being massively present in the tail, by assessing the WT distribution within the parotid gland.
  • In all sample, staging of parotid gland tumors was defined by sonography and magnetic resonance imaging.
  • Furthermore, tumor localization, size, bilaterality and multifocality were assessed according to radiological, intraoperative and histopathological findings.
  • CONCLUSION: Since the tail has been well known to present the greatest distribution of intra-parotid lymph nodes, our clinical findings on WT parotid localization could suggest the possible origin of this tumor from epithelial salivary gland ductal inclusions, as being likely entrapped during embryogenesis within the intra-parotid lymph nodes, and could support the hypothesis of a heterotopy in the pathogenesis of WT.
  • However, this suggestive hypothesis based only on clinical and "topographic" data should be confirmed by histopathological studies about the presence of the salivary ductal elements trapped within the intra-parotid lymph nodes.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 20502429.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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39. Shah N, Tighe JV, Barrett AW, Kumar S, Allen JP: Bilateral intraparotid and extraparotid Warthin's tumours. Br J Oral Maxillofac Surg; 2007 Apr;45(3):238-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral intraparotid and extraparotid Warthin's tumours.
  • Warthin's tumour is a benign adenoma in the parotid gland, but extraparotid and synchronous bilateral Warthin's tumours may occur.
  • In this report, we describe a patient with simultaneous bilateral involvement of the parotid glands and neck by multiple Warthin's tumours, an occurrence not previously described.
  • [MeSH-major] Adenolymphoma / diagnosis. Head and Neck Neoplasms / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 16207506.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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40. Tanaka S, Tabuchi K, Oikawa K, Kohanawa R, Okubo H, Ikebe D, Noguchi M, Hara A: Synchronous unilateral parotid gland neoplasms of three different histological types. Auris Nasus Larynx; 2007 Jun;34(2):263-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous unilateral parotid gland neoplasms of three different histological types.
  • A 67-year-old male with three synchronous tumors in the unilateral parotid gland is reported.
  • Postoperative histological examinations confirmed the presence of three synchronous primary tumors, specifically pleomorphic adenoma, Warthin's tumor and salivary duct carcinoma, in the right parotid gland.
  • To our knowledge, this is the first case report describing three different histological types in the unilateral parotid gland.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Salivary Ducts / pathology
  • [MeSH-minor] Aged. Humans. Male. Parotid Gland / pathology

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  • (PMID = 16938417.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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41. Roh JL, Kim JM, Park CI: Synchronous benign and malignant tumors in the ipsilateral parotid gland. Acta Otolaryngol; 2007 Jan;127(1):110-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous benign and malignant tumors in the ipsilateral parotid gland.
  • We report a unique case of synchronous unilateral parotid tumors in a 71-year-old man.
  • The main parotid lesion was preoperatively suggested to be adenocarcinoma by fine needle aspiration cytology.
  • A coexisting Warthin's tumor was also diagnosed on microscopic examination of total parotidectomy specimens.
  • We describe this case of rare synchronous salivary gland tumors exhibiting both benign and malignant components with a review of the literature.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / radiography. Adenolymphoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 17364340.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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42. Ascani G, Pieramici T, Rubini C, Messi M, Balercia P: Synchronous bilateral Warthin's tumours of the parotid glands: a case report. Acta Otorhinolaryngol Ital; 2010 Dec;30(6):310-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous bilateral Warthin's tumours of the parotid glands: a case report.
  • Warthin's tumour is the most frequent monomorphic adenoma of the major salivary glands, representing about 2-15% of all parotid tumours.
  • Most of the multifocal Warthin's tumours are unilateral, whereas bilateral Warthin's tumours are far less common; bilateral Warthin's tumours are metachronous with few synchronous cases having been described in the literature.
  • The Authors present an interesting case of simultaneously occurring bilateral Warthin's tumours growing in the parotid glands.
  • [MeSH-major] Adenolymphoma / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • [Cites] Eur Arch Otorhinolaryngol. 2008 Dec;265(12):1573-5 [18301907.001]
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  • (PMID = 21808453.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3146325
  • [Keywords] NOTNLM ; Bilateral tumours / Multifocal tumours / Parotid gland / Salivary gland tumours / Warthin's tumour
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43. Jezewska E, Scinska A, Kukwa W, Bienkowski P: Effects of benign parotid tumors on unstimulated saliva secretion from the parotid gland. Auris Nasus Larynx; 2009 Oct;36(5):586-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of benign parotid tumors on unstimulated saliva secretion from the parotid gland.
  • OBJECTIVE: Salivary tumors can manifest as abnormalities of the gland itself and/or changes in salivary flow.
  • The aim of the present study was to evaluate effects of benign parotid tumors on unstimulated saliva secretion from the affected gland.
  • METHODS: Unstimulated parotid saliva was collected bilaterally using the swab method in patients with unilateral pleomorphic adenoma (n=14) or Warthin's tumor (n=6).
  • Pre-weighted cotton rolls were placed at the opening of each parotid duct for 15min.
  • RESULTS: The range of salivary flow was similar to that found in studies on unstimulated parotid saliva.
  • No difference was found between the involved and non-involved side when the patients with pleomorphic adenoma or Warthin's tumor were separately analyzed.
  • CONCLUSION: The present results suggest that the most common benign parotid tumors do not alter unstimulated salivary flow from the affected gland.
  • [MeSH-major] Adenolymphoma / secretion. Adenoma, Pleomorphic / secretion. Parotid Gland / secretion. Parotid Neoplasms / secretion. Saliva / secretion

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  • (PMID = 19249167.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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44. Guldfred LA, Becker BC, Eiholm S: [Multiple synchronous tumours of different histological type of the salivary glands]. Ugeskr Laeger; 2008 Apr 28;170(18):1571

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Multiple synkrone tumorer med forskellig histologi i de store spytkirtler.
  • Here we report a 72-year-old woman who was diagnosed with simultaneously occurring Warthin's tumour of the left parotid and mixed tumour of the homolateral submandibular gland.
  • This case also illustrates the importance of thorough examination even after the identification of a single tumour, as multiple synchronous primary tumours--even if rare--can be a diagnostic possibility.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 18454930.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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45. Karthikeya P, Mahima VG, Shalini K: Papillary cystadenoma lymphomatosum: case report and review of literature. Indian J Dent Res; 2005 Oct-Dec;16(4):153-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary cystadenoma lymphomatosum: case report and review of literature.
  • Papillary Cystadenoma Lymphomatosum or Warthin's tumour is a unique neoplasm arising almost exclusively in the parotid salivary gland and is composed of oncocytic epithelium with a prominent lymphoid infiltrate.
  • The tumor is usually asymptomatic and may be associated with varying degrees of pain not necessarily an indication of malignant transformation in the tumour.
  • The tumour is managed easily by surgical excision.
  • This article presents a typical case arising in the right parotid gland of a 73-year-old male with review of literature of this rare tumour.
  • [MeSH-major] Adenolymphoma / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 16761709.001).
  • [ISSN] 0970-9290
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 26
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46. Herce-López J, Salazar-Fernández CI, Mayorga-Jiménez F, Gallana-Alvarez S, Pérez-Sánchez JM: Synchronous unilateral parotid neoplasms. A case report. Med Oral Patol Oral Cir Bucal; 2009 Feb;14(2):E90-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous unilateral parotid neoplasms. A case report.
  • The parotid gland is the most usual location of benign neoplasms affecting major salivary glands and quite often the recurrence of these tumours is noticed, specially in the case of pleomorphic adenoma.
  • The occurrence of multiple tumours in the parotid glands is rare and the majority of these are multifocal Warthin's tumors (papillary cystadenoma lymphomatosum).
  • The simultaneous development of tumours with different histological types is unusual and when it occurs, the most common combination is a pleomorphic adenoma and a Warthin's tumor.
  • There are many articles about Multiple Parotid Tumors (MPT) but only a few of them are focused on unilateral synchronous benings tumors, being pleomorphic adenoma and Warthin's these tumors.
  • The report describes a 55 year old female with a pleomorphic adenoma occurring synchronously with a Warthin's tumor within the superficial lobe of her left parotid gland.
  • [MeSH-major] Adenolymphoma. Adenoma, Pleomorphic. Neoplasms, Multiple Primary. Parotid Neoplasms

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  • (PMID = 19179956.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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47. Saussez S, de Leval L, Decaestecker C, Sirtaine N, Cludts S, Duray A, Chevalier D, André S, Gabius HJ, Remmelink M, Leroy X: Galectin fingerprinting in Warthin's tumors: lectin-based approach to trace its origin? Histol Histopathol; 2010 05;25(5):541-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Galectin fingerprinting in Warthin's tumors: lectin-based approach to trace its origin?
  • Warthin's tumor of the parotid gland is assumed to originate from the proliferation of epithelial inclusions within parotid lymph nodes.
  • In that case, these cells are supposed to retain characteristics similar to common salivary gland ductal cells.
  • Besides defining the galectin histochemical parameters in Warthin's tumors this study adds support to the hypothesis of heterotopia.
  • [MeSH-major] Adenolymphoma / metabolism. Galectins / metabolism. Parotid Neoplasms / metabolism

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  • (PMID = 20238293.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Galectin 1; 0 / Galectin 3; 0 / Galectins; 0 / LGALS1 protein, human; 0 / LGALS7 protein, human; 0 / LGALS8 protein, human
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48. Zainal A, Razif MY, Makhashen M, Swaminathan M, Mazita A: Necrobiotic xanthogranuloma of the parotid gland. J Laryngol Otol; 2010 May;124(5):569-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Necrobiotic xanthogranuloma of the parotid gland.
  • OBJECTIVES: To highlight the first reported case of necrobiotic xanthogranuloma of the parotid gland.
  • RESULTS: A 48-year-old man presented with a right parotid mass.
  • Fine needle aspiration cytology was suggestive of Warthin's tumour, for which the patient underwent a subtotal parotidectomy.
  • CONCLUSIONS: Necrobiotic xanthogranuloma may clinically mimic commoner tumours such as Warthin's tumour.
  • [MeSH-major] Granuloma / pathology. Parotid Diseases / pathology. Xanthomatosis / pathology

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  • (PMID = 19825226.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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49. Suwała P, Wilczyński K, Barnaś S, Prudlak E: [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma]. Otolaryngol Pol; 2009 Sep;63(7):89-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma].
  • AIM OF THE WORK: The authors present unusually rare case primary multiple synchronicus benign tumor of the ipsilateral parotid gland: oncocytoma and Warthin's tumor, which is rare among occasionally occurred multiple tumors with different histology in the salivary glands.
  • MATERIAL AND METHOD: A 71-year-old man presented with the tumor in the right parotid gland.
  • We performed excision of the superficial lobe of the parotid gland.
  • The preoperative ultrasonography and macroscopic analysis of the removed parotid gland tissue revealed only one tumor recognised histopathologically as adenolimphoma, but upon histopathological examination Warthin's tumor proved to coexist with oncocytoma.
  • The superficial parotidectomy protects from the recrudescence of the superficial lobe of the parotid gland tumors.
  • The coexistence of the oncocytoma and Warthin's in one parotid gland is extremely rare.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Oxyphilic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Aged. Humans. Male. Parotid Gland / pathology. Rare Diseases. Treatment Outcome

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  • (PMID = 20564910.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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50. Grosheva M, Ortmann M, Beutner D: [Facial nerve palsy due to a benign parotid gland tumor]. HNO; 2010 Dec;58(12):1197-8, 1200

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Facial nerve palsy due to a benign parotid gland tumor].
  • Facial nerve palsy is rarely associated with an inflammatory parotid process.
  • We present a case of peripheral facial palsy initiated by infection of a cystadenolymphoma of the parotid gland.
  • Histological work-up yielded a diagnosis of Warthin's tumor with necrotic changes.
  • [MeSH-major] Adenolymphoma / complications. Facial Paralysis / complications. Parotid Neoplasms / complications
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Necrosis. Parotid Gland / pathology. Parotid Gland / surgery. Parotitis / diagnosis. Ultrasonography

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  • [Cites] Arch Otolaryngol Head Neck Surg. 2000 Apr;126(4):506-10 [10772305.001]
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  • (PMID = 20607202.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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51. Uchida Y, Minoshima S, Kawata T, Motoori K, Nakano K, Kazama T, Uno T, Okamoto Y, Ito H: Diagnostic value of FDG PET and salivary gland scintigraphy for parotid tumors. Clin Nucl Med; 2005 Mar;30(3):170-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of FDG PET and salivary gland scintigraphy for parotid tumors.
  • PURPOSE: The purpose of this study was to examine the diagnostic value of the combination of F-18 fluorodeoxyglucose (FDG) PET and Tc-99m pertechnetate salivary gland scintigraphy in parotid tumors.
  • MATERIALS AND METHODS: Seventy-two patients with benign parotid gland tumors (n = 52), malignant parotid tumors (n = 12), and inflammation (n = 8) underwent both FDG PET and salivary gland scintigraphy within 1 week, and 66 of the patients also underwent gallium scintigraphy.
  • RESULTS: Malignant parotid tumors showed significantly higher FDG uptake (standard uptake values [SUVs]) than both benign tumors and inflammation, except in Warthin's tumor (5.82 +/- 3.95 vs. 2.07 +/- 1.33; P <0.01).
  • Although the SUV values of Warthin's tumor and malignant parotid tumors overlapped somewhat, Warthin's tumor did demonstrate increased radiotracer uptake, and it was reliably distinguished from other parotid gland tumors by the use of salivary gland scintigraphy.
  • Considering a SUV value >3 as being positive for malignancy and excluding Warthin's tumor on the basis of salivary gland scintigraphy, sensitivity and specificity of FDG PET were 75% and 80%, respectively.
  • CONCLUSIONS: Although the diagnostic value of FDG PET in the differentiation of malignant from benign parotid gland tumors was limited because of the high FDG uptake in some benign tumors, and particularly pleomorphic adenomas, combining salivary gland scintigraphy with FDG PET may help to negate this drawback, and this combination may be a more promising approach for differentiation of various parotid gland tumors in patients compared with nondiagnostic needle aspiration.
  • [MeSH-major] Fluorodeoxyglucose F18. Parotid Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods

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  • (PMID = 15722820.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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52. Gürbüz Y, Yildiz K, Aydin O, Almaç A: Immunophenotypical profiles of salivary gland tumours: a new evidence for their histogenetic origin. Pathologica; 2006 Apr;98(2):147-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunophenotypical profiles of salivary gland tumours: a new evidence for their histogenetic origin.
  • The histogenetic origin of salivary gland tumours is not clear.
  • In this study, we examine the immunophenotypic properties of salivary gland tumours in order to obtain further insight into their histogenesis.
  • 30 cases of salivary gland tumours (18 pleomorphic adenomas, 8 Warthin's tumours, 2 basal cell adenomas, 2 acinic cell carcinomas) were included in our study.
  • SMA was not detected in Warthin's tumour (p < 0.0001).
  • CK10 immunoreactivity was observed in 5 Warthin's tumour.
  • Immunophenotypic profile of Warthin's tumour is suggestive of an embryological remnant origin.
  • [MeSH-major] Actins / analysis. Keratins / analysis. Neoplasm Proteins / analysis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma / chemistry. Adenolymphoma / pathology. Adenoma / chemistry. Adenoma / pathology. Adenoma, Pleomorphic / chemistry. Adenoma, Pleomorphic / pathology. Carcinoma, Acinar Cell / chemistry. Carcinoma, Acinar Cell / pathology. Humans. Immunophenotyping. Organ Specificity. Protein Isoforms / analysis. Retrospective Studies

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  • (PMID = 16929788.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Actins; 0 / Neoplasm Proteins; 0 / Protein Isoforms; 68238-35-7 / Keratins
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53. Roy S, Dhingra KK, Gupta P, Khurana N, Gupta B, Meher R: Acinic cell carcinoma with extensive neuroendocrine differentiation: a diagnostic challenge. Head Neck Pathol; 2009 Jun;3(2):163-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary salivary gland carcinoma with neuroendocrine differentiation is of rare occurrence, especially so in the parotid gland.
  • Amongst the various reported primary tumors with neuroendocrine differentiation, acinic cell carcinoma (ACC) one such tumor.
  • Fine Needle Aspiration Cytology (FANC) yielded a cystic fluid suggesting a possibility of Warthin's tumor or Oncocytic lesion.
  • Intraoperative findings were suggestive of a Warthin's tumor.
  • Initial histopathological examination of the tumor was suggestive of neuroendocrine carcinoma.
  • The possibility of neuroendocrine differentiation in a primary salivary gland tumor should be kept in mind whenever a salivary gland tumor shows only neuroendocrine histology.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma / pathology. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged

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  • [Cites] Pathobiology. 1990;58(4):212-20 [1701303.001]
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  • (PMID = 19644544.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Acinic cell / Carcinoma / Chromogranin / Neuroendocrine / Parotid / Warthin’s
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54. Nouraei SA, Ismail Y, Ferguson MS, McLean NR, Milner RH, Thomson PJ, Welch AR: Analysis of complications following surgical treatment of benign parotid disease. ANZ J Surg; 2008 Mar;78(3):134-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of complications following surgical treatment of benign parotid disease.
  • The commonest pathology was benign pleomorphic adenoma (43%), followed by Warthin's tumour (30%) and chronic sialadenitis (22%).
  • Parotid duct ligation increased the risk of nerve palsy in the distribution of zygomatic and buccal branches.
  • Operations for Warthin's tumour were associated with an increased risk of dysfunction of the cervical branch of the nerve.
  • CONCLUSION: The incidence of postoperative complications was influenced by the pathology, with inflammatory lesions significantly increasing the risk of facial nerve dysfunction and other complications, but also by variations in surgical practice, such as parotid duct ligation.
  • [MeSH-major] Facial Paralysis / epidemiology. Otorhinolaryngologic Surgical Procedures / adverse effects. Parotid Diseases / pathology. Parotid Diseases / surgery. Parotid Gland / surgery. Postoperative Complications / epidemiology
  • [MeSH-minor] Adenolymphoma / pathology. Adenolymphoma / surgery. Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Female. Humans. Immunohistochemistry. Incidence. Male. Middle Aged. Prognosis. Retrospective Studies. Risk Assessment. Sex Distribution. Sialadenitis / pathology. Sialadenitis / surgery. South Australia / epidemiology

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  • (PMID = 18269474.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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55. Linecker A, Kermer C, Sulzbacher I, Angelberger P, Kletter K, Dudczak R, Ewers R, Becherer A: Uptake of (18)F-FLT and (18)F-FDG in primary head and neck cancer correlates with survival. Nuklearmedizin; 2008;47(2):80-5; quiz N12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumour tracer uptake was determined by standardized uptake value (SUV) normalized to body weight and /non-tumor ratios (T/N). (18)F-FDG and (18)F-FLT uptake were compared with histopathologic and immunohistochemical results.
  • RESULTS: 19 patients had malignant tumours; one patient had a benign cystadenoma (so called Warthin's tumour) of the parotid gland.
  • One negative lesion turned out to be a malignant T1 stage squamous cell carcinoma in both PET scans, the Warthin's tumour was false positive with (18)F-FDG but showed only faint uptake with (18)F-FLT, resulting in a sensitivity of 95 % for both tracers.

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  • (PMID = 18392317.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Dideoxynucleosides; 0 / Fluorine Radioisotopes; 0 / Radioisotopes; 0Z5B2CJX4D / Fluorodeoxyglucose F18; PG53R0DWDQ / alovudine
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56. Ungari C, Paparo F, Colangeli W, Iannetti G: Parotid glands tumours: overview of a 10-year experience with 282 patients, focusing on 231 benign epithelial neoplasms. Eur Rev Med Pharmacol Sci; 2008 Sep-Oct;12(5):321-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid glands tumours: overview of a 10-year experience with 282 patients, focusing on 231 benign epithelial neoplasms.
  • Salivary gland tumours are uncommon, representing less than 6% of head and neck neoplasm.
  • Pleomorphic adenoma is the most common benign epithelial salivary gland neoplasm, comprising 50%-74% of all parotid tumours.
  • It is followed by Warthin's tumour (4-14%).
  • The authors retrospectively reviewed 282 eligible patients surgically treated for parotid gland tumours in the last 10 years, focusing on 231 benign epithelial neoplasms.
  • The diagnosis of a parotid gland neoplasm must be considered in any patient presenting with a lump near the mandible.
  • Smoking habit is important in Warthin's tumour pathogenesis.
  • Tumour pseudopodia and capsule ruptures are recognised factors involved in pleomorphic adenoma recurrences but also tumour multicentricity might play an important role.
  • [MeSH-major] Epithelium / surgery. Parotid Neoplasms / surgery

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  • (PMID = 19024217.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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57. Heeremans EH, Mastboom WJ: [Subtotal parotidectomy for a parotid gland tumour in two players of wind instruments, with preservation of facial nerve function]. Ned Tijdschr Geneeskd; 2007 Mar 3;151(9):543-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Subtotal parotidectomy for a parotid gland tumour in two players of wind instruments, with preservation of facial nerve function].
  • [Transliterated title] Subtotale parotidectomie wegens een parotistumor bij twee blaasmuzikanten, met behoud van de N.-facialisfuncties.
  • Two professional musicians, a 55-year-old clarinet player and a 58-year-old trumpet player, presented to the surgical outpatient clinic with a Warthin's tumour and a pleomorphic adenoma in the deep lobe of the parotid gland, respectively.
  • The several branches of the facial nerve form the virtual plane between the superficial and deep lobes of the parotid gland.
  • Due to the localisation of this nerve, parotid surgery entails a significant risk of neurapraxia of the facial nerve branches.
  • Before the operation, both patients were informed carefully about both the necessity and the risks of surgical excision of parotid tumours.
  • [MeSH-major] Adenolymphoma / surgery. Adenoma, Pleomorphic / surgery. Facial Nerve / physiology. Parotid Neoplasms / surgery

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  • (PMID = 17373397.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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58. Pastore A, Carinci F, Pelucchi S: Genetic expression profiling of parotid neoplasms by cDNA microarrays. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):153-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic expression profiling of parotid neoplasms by cDNA microarrays.
  • Differentially expressed genes in various benign and malignant salivary gland tumours were identified by use of cDNA microarrays containing 19,000 human expressed sequence tags.
  • Samples were derived from 5 patients with pleomorphic adenoma, 4 with Warthin's tumour, one with clear cell carcinoma, and 2 with mucoepidermoid carcinoma.
  • Benign Warthin's tumour and pleomorphic adenoma showed very distinctive gene expression patterns.
  • A total of 133 genes differentiated the single malignant clear cell carcinoma from non-tumour salivary glands (p < 0.01), whereas only 16 genes separated it from the highly related benign pleomorphic adenoma (p < 0.01).
  • The results show gene expression alterations common to all tumours and unique to each benign and malignant tumour.
  • The numerous Expressed Sequence Tags of unknown function we identified could also become useful as tumour markers and represent a set of novel tumour-associated genes.
  • [MeSH-major] Gene Expression Profiling. Oligonucleotide Array Sequence Analysis. Parotid Neoplasms / genetics

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  • (PMID = 16450770.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639868
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59. Li LJ, Li Y, Wen YM, Liu H, Zhao HW: Clinical analysis of salivary gland tumor cases in West China in past 50 years. Oral Oncol; 2008 Feb;44(2):187-92
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  • [Title] Clinical analysis of salivary gland tumor cases in West China in past 50 years.
  • In our study, 3461 cases of salivary gland tumor treated between 1955 and 2002 at West China Stomatology Hospital of Sichuan University were retrospectively analyzed, and compared with the previous reports.
  • Measures such as age, tumor location, tumor histological type, and the nature of the growth (benign or malignant) were recorded at the same time.
  • The findings are as follows: the average ages of salivary gland tumor patients were 41.38 years for the benign cases and 45.20 for the malignant ones; the male:female ratio was 0.
  • 99:1 in the benign cases and 1.34:1 in the malignant ones; primary tumors were mostly in the parotid gland, palate and submandibular gland in sequence.
  • Pleomorphic adenoma was the most frequent benign tumor followed by Warthin's tumor and basal cell adenoma, whereas mucoepidermoid carcinoma, adenoid cystic carcinoma and adenocarcinoma not otherwise specified were the most frequent malignant tumors.
  • The incidence of salivary gland tumors increased with age.
  • The parotid gland and palate were the most common locations of salivary gland tumors.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenolymphoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Child. Child, Preschool. China / epidemiology. Female. Humans. Incidence. Infant. Male. Middle Aged. Palatal Neoplasms / pathology. Parotid Neoplasms / pathology. Retrospective Studies

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  • [ErratumIn] Oral Oncol. 2011 Sep;47(9):929-30
  • (PMID = 17418612.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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60. Tian Z, Li L, Wang L, Hu Y, Li J: Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg; 2010 Mar;39(3):235-42
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  • [Title] Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population.
  • There is little information in the English-language literature about the epidemiology of salivary gland neoplasms in the eastern Chinese population.
  • A large retrospective study (6982 primary salivary tumors during 23 years) was carried out to investigate the clinicopathological features (tumor location, patient sex and age) of these tumors in this population.
  • Pleomorphic adenoma (69%) was the most common tumor and 20% were located in minor glands.
  • 92% of Warthin's tumors occurred in males.
  • Relatively higher incidences of minor gland tumors and specifically of pleomorphic adenoma in minor glands were noted.
  • The historical significant male predominance of Warthin's tumor was confirmed.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. China / epidemiology. Female. Humans. Incidence. Male. Middle Aged. Palatal Neoplasms / epidemiology. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Sex Factors. Submandibular Gland Neoplasms / epidemiology. Young Adult

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  • (PMID = 19951834.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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61. Chan WH, Lee KW, Chiang FY, Ho KY, Chai CY, Kuo WR: Features of parotid gland diseases and surgical results in southern Taiwan. Kaohsiung J Med Sci; 2010 Sep;26(9):483-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Features of parotid gland diseases and surgical results in southern Taiwan.
  • Various parotid gland diseases are seen clinically, including inflammation, sialolithiasis, and benign and malignant tumors.
  • Here, we investigated the relationship between tumor characteristics and pathology, and considered whether the former could be used to differentiate malignant from benign parotid gland diseases.
  • The most common benign disease was pleomorphic adenoma (115 cases, 36.4%), but the most common disease in male patients was Warthin's tumor, a finding which, as far as we aware, has not been previously been reported in the literature.
  • The incidence of Warthin's tumor seems to be increasing.
  • Compared with benign disease, malignant parotid gland disease more often presents as a hard, painful, fixed and large mass (> 3 cm), and more often involves the deep lobe of the parotid gland.
  • However, there was no difference in transient facial palsy rate between benign and malignant parotid gland disease, although parotid gland cancer had a higher incidence of permanent facial palsy postoperatively.
  • [MeSH-major] Parotid Diseases / pathology. Parotid Diseases / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Parotid Gland / pathology. Parotid Gland / surgery. Postoperative Complications / epidemiology. Retrospective Studies. Taiwan / epidemiology. Treatment Outcome. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • [CommentIn] Kaohsiung J Med Sci. 2012 Jun;28(6):350-1 [22632893.001]
  • (PMID = 20837345.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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62. Hilton JM, Phillips JS, Hellquist HB, Premachandra DJ: Multifocal multi-site Warthin tumour. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1573-5
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  • [Title] Multifocal multi-site Warthin tumour.
  • The unique case of a 55-year-old man with multifocal adenolymphoma (Warthin's tumour) of both parotid glands, the neck and post-nasal space is presented.
  • Warthin tumour is almost exclusively a parotid tumour but is known to be bilateral in 7-10% of cases and multifocal in 2% of cases.
  • Most extraglandular Warthin tumours have been located in neck lymph nodes and only a few cases have been reported from other sites.
  • The presented case is unique in having synchronous and metachronous Warthin tumours, as well as one of the tumours being neither truly parotid, nor within a lymph node.
  • [MeSH-major] Adenolymphoma / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Second Primary / pathology. Nose Neoplasms / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18301907.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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63. Ozcan C, Apa DD, Vayisoglu Y, Görür K: Unilateral parotid gland involvement with synchronous multiple Basal cell adenomas. J Craniofac Surg; 2007 Nov;18(6):1470-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral parotid gland involvement with synchronous multiple Basal cell adenomas.
  • Basal cell adenoma (BCA) is a rare benign epithelial tumor of the salivary gland.
  • BCA is seen most frequently in the parotid gland and less commonly in the submandibular gland and minor glands of the upper lips, oral cavity, and hard palate.
  • Salivary gland tumors are observed as single tumors in one salivary gland.
  • Double or multiple tumors of the salivary gland tumors are unusual and metachronous or bilateral salivary gland tumors are more observed than synchronous or unilateral tumors.
  • The most commonly seen multiple tumor unilaterally or bilaterally is the Warthin's tumor.
  • Physical examination revealed two solid and well-delineated masses in the preauricular region, which were 1.5 x 1 cm in diameter and in the tail of the parotid gland, which is 2.5 x 2 cm in diameter.
  • Excision of the superficial lobe of the parotid gland was performed.
  • Multiple synchronous nonmembranous-type BCAs of the unilateral parotid gland is a rare entity.
  • More extensive excision of the parotid gland tumor, careful macroscopic perioperative examination of the surgical specimen, and histologic evaluation of all surgical specimens might be necessary for reducing revision operations and surgical complications.
  • [MeSH-major] Adenoma / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma / diagnosis. Aged. Diagnosis, Differential. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 17993904.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Varshavskiĭ AI: [Clinics, diagnostics and treatment of parotid salivary gland adenomas]. Stomatologiia (Mosk); 2010;89(3):41-4
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  • [Title] [Clinics, diagnostics and treatment of parotid salivary gland adenomas].
  • Clinical data of 252 patients with parotid gland adenomas (PGA) were produced.
  • Pleomorphic adenoma (PA) was found in 81.3% of PGA cases, adenolymphoma (Warthin's tumor) - in 13%, canalicular adenoma - in 2.8%, other adenomas - in 2.9% of observations.
  • PA more often was met in women, adenolymphoma - in men.
  • 2 cases of myoepithelioma and cystadenoma of parotid gland were described.
  • The following operations were performed: extracapsular tumorectomy - in 13 patients, adenomectomy with limited gland resection - in 152 patients, subtotal gland resection with nervus facialis separation - in 62 patients, parotidectomy with nervus facialis preservation - in 25 patients.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / surgery. Parotid Neoplasms / diagnosis. Parotid Neoplasms / surgery

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  • (PMID = 20559235.001).
  • [ISSN] 0039-1735
  • [Journal-full-title] Stomatologii︠a︡
  • [ISO-abbreviation] Stomatologiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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65. Vageli D, Sourvinos G, Ioannou M, Koukoulis GK, Spandidos DA: High-risk human papillomavirus (HPV) in parotid lesions. Int J Biol Markers; 2007 Oct-Dec;22(4):239-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-risk human papillomavirus (HPV) in parotid lesions.
  • Although several studies have reported that oropharyngeal infection with HPV may predispose to tumorigenesis, little is known about the etiological factors of salivary gland tumors and the presence of HPV.
  • We studied 9 parotid lesions for HPV infection including an oncocytoma, an acinic cell carcinoma, a high-grade adenocarcinoma, a low-grade polymorphous adenocarcinoma, a Warthin's tumor and 2 pleomorphic adenomas, a lymphoepithelial cyst and a lipoma of the parotid gland.
  • Seven of the 9 parotid lesions were HPV positive while 6 of these 7 had been infected by HPV16 and/or HPV18 oncogenic types.
  • High viral load of highrisk genotypes of HPV was found in the oncocytoma, in one of the pleomorphic adenomas, and in the Warthin's tumor.
  • Finally, in situ PCR indicated that HPV16 amplification occurred in the salivary gland tumors.
  • This is the first time that highrisk HPV genotypes are detected in these histological types of parotid lesions, suggesting the possible involvement of the virus in the disease.
  • [MeSH-major] Papillomaviridae / metabolism. Papillomavirus Infections / virology. Parotid Gland / pathology. Parotid Neoplasms / virology. Salivary Gland Neoplasms / virology

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  • [CommentIn] Int J Biol Markers. 2011 Oct-Dec;26(4):278-80 [22180174.001]
  • (PMID = 18161653.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / DNA Probes, HPV
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66. Giannone N, Lo Muzio L, Politi M: Extracapsular lumpectomy and SMAS flap for benign parotid tumours: an early outcome in a small number of cases on Frey's syndrome and facial nerve dysfunction. J Craniomaxillofac Surg; 2008 Jun;36(4):239-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extracapsular lumpectomy and SMAS flap for benign parotid tumours: an early outcome in a small number of cases on Frey's syndrome and facial nerve dysfunction.
  • The aim of the present study was to retrospectively analyse no. 34 extracapsular lumpectomies (ELs) performed with superficial musculoaponeurotic system (SMAS) flaps on 32 patients for benign parotid tumours.
  • None of the patients affected by pleomorphic adenoma or Warthin's tumour had a complete facial palsy.
  • [MeSH-major] Adenolymphoma / surgery. Adenoma, Pleomorphic / surgery. Oral Surgical Procedures / adverse effects. Parotid Neoplasms / surgery. Surgical Flaps

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  • (PMID = 18313936.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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67. Woo PC, Tse H, Lau SK, Leung KW, Woo GK, Wong MK, Ho CM, Yuen KY: Alkanindiges hongkongensis sp. nov. A novel Alkanindiges species isolated from a patient with parotid abscess. Syst Appl Microbiol; 2005 Jun;28(4):316-22
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  • [Title] Alkanindiges hongkongensis sp. nov. A novel Alkanindiges species isolated from a patient with parotid abscess.
  • A bacterium was isolated from the abscess pus of a 72-year-old patient with Warthin's tumor and parotid abscess.
  • [MeSH-major] Abscess / microbiology. Moraxellaceae / classification. Moraxellaceae / isolation & purification. Moraxellaceae Infections / complications. Moraxellaceae Infections / microbiology. Parotid Diseases / microbiology. Parotid Gland / microbiology
  • [MeSH-minor] Acinetobacter / genetics. Adenolymphoma / complications. Adenolymphoma / microbiology. Aerobiosis. Aged. Base Composition. DNA, Bacterial / chemistry. DNA, Bacterial / isolation & purification. DNA, Ribosomal / chemistry. DNA, Ribosomal / isolation & purification. Genes, rRNA. Hong Kong. Humans. Male. Molecular Sequence Data. Parotid Neoplasms / complications. Parotid Neoplasms / microbiology. Phylogeny. RNA, Ribosomal, 16S / genetics. Transformation, Bacterial

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  • (PMID = 15997704.001).
  • [ISSN] 0723-2020
  • [Journal-full-title] Systematic and applied microbiology
  • [ISO-abbreviation] Syst. Appl. Microbiol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AF543466/ AY251390/ AY251391
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Bacterial; 0 / DNA, Ribosomal; 0 / RNA, Ribosomal, 16S
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68. Uğuz MZ, Onal HK, Eroğlu OO, Etit D: [Sensitivity and specificity of fine needle aspiration biopsy in parotid masses]. Kulak Burun Bogaz Ihtis Derg; 2007;17(2):96-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sensitivity and specificity of fine needle aspiration biopsy in parotid masses].
  • OBJECTIVES: We aimed to determine the sensitivity and specificity of fine needle aspiration biopsy (FNAB) in patients with parotid masses.
  • PATIENTS AND METHODS: The study included 29 patients (15 males, 14 females; mean age 52 years; range 20 to 83 years) who underwent FNAB and parotidectomy for parotid masses.
  • The most common histopathological diagnosis was pleomorphic adenoma (n=7, 24.1%), followed by mucoepidermoid carcinoma (n=4, 13.8%), and Warthin's tumor (n=3, 10.3%).
  • CONCLUSION: Preoperative FNAB for parotid masses plays an important role in planning surgery.
  • [MeSH-major] Biopsy, Fine-Needle / standards. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenolymphoma / pathology. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 17527061.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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69. Kanazawa T, Ohta Y, Goutsu K, Takeoda K, Tsubaki K, Kodama K, Inoue R, Usubuchi H, Iino Y: [Significant factors affecting the operation time for benign parotid tumor]. Nihon Jibiinkoka Gakkai Kaiho; 2008 Jun;111(6):481-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Significant factors affecting the operation time for benign parotid tumor].
  • Tumors of the parotid gland are fairly frequent among head and neck tumors.
  • To measure the operation time and determine the factors affecting it, 71 cases, including 43 cases of pleomorphic adenomas and 28 cases Warthin's tumor, were retrospectively reviewed to the determine if the operation time depended on the age, sex, operated side, presence of complications, BMI, bleeding volume, tumor size, tumor location, exposure of branches of the facial nerve, and experience of the surgeon.
  • The results revealed that the bleeding volume, tumor size, tumor location and experience of the surgeon were significantly correlated with the operation time, whereas age, sex, operated side, presentation of complications and BMI showed no correlation with the operation time.
  • [MeSH-major] Parotid Neoplasms / surgery

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  • (PMID = 18634454.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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70. Righi A, Foschini MP: [Values and limits in fine needle aspiration in the diagnosis of Warthin tumour of the parotid gland]. Pathologica; 2006 Dec;98(6):635-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Values and limits in fine needle aspiration in the diagnosis of Warthin tumour of the parotid gland].
  • [Transliterated title] Valori e limiti dell'agoaspirato nella diagnosi di tumore di Warthin della parotide.
  • Recent paper state that cytological diagnosis of Warthin Tumour of the parotid gland is poorly reproducible and that aspiration procedures damage the tumoral tissue as to make difficult the histological diagnosis.
  • Aim of the present study is to review cytological sampling performed with fine needle sampling without aspiration and to compare them with the relative surgical specimens in order to determine the value of fine needle aspiration in the diagnosis of Warthin Tumour and to quantify' the damage in histological tissue.
  • MATERIALS AND METHOD: All cases with cytological and/or histological diagnosis of Warthin Tumour during the period 1/1/98 to 30/6/04 were retrieved.
  • RESULTS: 38 cases were selected corresponding to 37 patients (1 case of Warthin Tumour bilateral): all tumors were localized in the parotid gland.
  • In all cases the histologic alterations from fine needle were focal, limited to less than 20% of the tumoral area (first category of Batsakis 'classification), and did not prevent the histologic diagnosis of Warthin Tumour.
  • CONCLUSIONS: These data suggest that fine needle aspiration without aspiration is a valuable tool for the per-operative diagnosis of Warthin Tumour.
  • [MeSH-major] Adenolymphoma / pathology. Biopsy, Needle. Parotid Neoplasms / pathology

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  • (PMID = 17285840.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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71. de Oliveira FA, Duarte EC, Taveira CT, Máximo AA, de Aquino EC, Alencar Rde C, Vencio EF: Salivary gland tumor: a review of 599 cases in a Brazilian population. Head Neck Pathol; 2009 Dec;3(4):271-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland tumor: a review of 599 cases in a Brazilian population.
  • Salivary gland tumors consist of a group of heterogeneous lesions with complex clinicopathological characteristics and distinct biological behaviors.
  • Worldwide series show a contrast in the relative incidence of salivary gland tumors, with some discrepancies in clinicopathological data.
  • Parotid gland tumors were the most frequent (68.5% of cases) and patient age ranged from 1 to 88 years-old (median of 45 years old).
  • The most frequent tumors were pleomorphic adenomas (68.4%) and benign tumors were significantly more frequent in the parotid (75.9%), while malignant tumors were more frequent in the minor salivary glands (40%) (P < 0.05).
  • In conclusion, women and the parotid gland were the most affected and pleomorphic adenoma was the most frequent lesion, followed by adenoid cystic carcinoma and Warthin's tumor.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / pathology

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  • [Cites] J Craniomaxillofac Surg. 2000 Feb;28(1):56-61 [10851675.001]
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  • (PMID = 20596844.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 15
  • [Other-IDs] NLM/ PMC2811571
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72. Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G: Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. Genes Chromosomes Cancer; 2005 Jun;43(2):202-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.
  • Recent studies have shown that the t(11;19)(q21;p13) translocation in mucoepidermoid carcinomas and benign Warthin's tumors results in a fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a.
  • Here we show that a third tumor type, clear cell hidradenoma of the skin, also expresses this gene fusion.
  • These results demonstrate that the t(11;19) in mucoepidermoid carcinoma, Warthin's tumor, and clear cell hidradenoma targets the same genes and results in identical gene fusions, indicating that at least subgroups of these glandular tumors evolve through activation of the same molecular pathways.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15729701.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Transcription Factors
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73. Sheahan P, Hafidh M, Toner M, Timon C: Unexpected findings in neck dissection for squamous cell carcinoma: incidence and implications. Head Neck; 2005 Jan;27(1):28-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These included metastatic papillary thyroid carcinoma, leukemia, lymphoma, Warthin's tumor, and tuberculosis.
  • [MeSH-minor] Adenolymphoma / pathology. Adenolymphoma / therapy. Aged. Aged, 80 and over. Carcinoma, Papillary / pathology. Carcinoma, Papillary / secondary. Carcinoma, Papillary / surgery. Cricoid Cartilage / pathology. Female. Humans. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / therapy. Lymphatic Metastasis. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell / therapy. Male. Middle Aged. Retrospective Studies. Thyroid Neoplasms / pathology. Thyroid Neoplasms / secondary. Thyroid Neoplasms / surgery. Thyroidectomy. Tuberculosis, Lymph Node / drug therapy. Tuberculosis, Lymph Node / pathology

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  • [Copyright] Copyright 2004 Wiley Periodicals, Inc.
  • (PMID = 15459919.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Krishnanand G, Kaur M, Rao RV, Monappa V: Oncocytic variant of mucoepidermoid carcinoma of submandibular gland: an unusual clinical and morphological entity. Indian J Pathol Microbiol; 2007 Jul;50(3):538-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncocytic variant of mucoepidermoid carcinoma of submandibular gland: an unusual clinical and morphological entity.
  • In this case report we describe a rare tumor--Oncocytic variant of Mucoepidermoid carcinoma of the submandibular salivary gland with a review of the literature.
  • Oncocytic metaplasia in salivary glands is a benign change that is associated with increasing age and also seen in a few salivary gland neoplasms', which include oncocytoma, Warthin's tumor, and the rare, oncocytic carcinoma.
  • Only twelve well-documented cases of oncocytic MEC have been reported previously all of which occurred in the parotid gland.
  • To the best of our knowledge this is the first case of oncocytic mucoepidermoid carcinoma involving the submandibular salivary gland.
  • The recognition of this entity is important, since most of the other primary oncocytic lesions of the salivary gland are benign.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 17883126.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 10
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75. Nakahara T, Suzuki T, Hashimoto J, Shigematsu N, Tomita T, Ogawa K, Kubo A: Role of salivary gland scintigraphy with Tc-99m pertechnetate in determining treatment of solitary parotid gland tumors: a retrospective study. Clin Nucl Med; 2007 May;32(5):363-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of salivary gland scintigraphy with Tc-99m pertechnetate in determining treatment of solitary parotid gland tumors: a retrospective study.
  • PURPOSE OF THE REPORT: Although salivary gland scintigraphy has been useful for the diagnosis of Warthin's tumor (WT), there are no reports concerning the clinical impact of this scintigraphy.
  • MATERIALS AND METHODS: We retrospectively investigated 127 patients with solitary parotid tumors who had undergone salivary gland scintigraphy.
  • CONCLUSIONS: The high percentage of nonsurgical patients suspected to have WT can be explained by the high diagnostic accuracy of salivary gland scintigraphy, which is useful for determining further management when surgery is contraindicated or is refused by the patient.
  • [MeSH-major] Parotid Gland / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / radionuclide imaging. Parotid Neoplasms / therapy. Radionuclide Imaging / methods. Sodium Pertechnetate Tc 99m / pharmacology

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  • (PMID = 17452863.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] A0730CX801 / Sodium Pertechnetate Tc 99m
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76. Kara MI, Göze F, Ezirganli S, Polat S, Muderris S, Elagoz S: Neoplasms of the salivary glands in a Turkish adult population. Med Oral Patol Oral Cir Bucal; 2010 Nov;15(6):e880-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • STUDY DESIGN: The histological diagnosis records of the Department of Pathology at Cumhuriyet University were reevaluated for 125 patients who were treated for salivary gland tumors from 1987 to 2008.
  • RESULTS: A total of 125 primary salivary gland neoplasms, consisting of 95 (76%) benign and 30 (24%) malignant groups were recorded.
  • The most common major and minor salivary gland sites were the parotid (61.6%) and palatal glands (9.6%), respectively.
  • Pleomorphic adenoma was the most frequent benign tumor followed by Warthin's tumor.
  • CONCLUSIONS: Although there were some discrepancies, the characteristics of salivary gland tumors of Turkish patients are in line with those of patients from other countries according to tumor type, tumor site distribution, and age and sex of patients.
  • [MeSH-major] Salivary Gland Neoplasms / pathology

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  • (PMID = 20526249.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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77. Van Lierop AC, Fagan JJ: Parotidectomy in Cape Town--a review of pathology and management. S Afr J Surg; 2007 Aug;45(3):96-8, 100, 102-3
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  • BACKGROUND: The spectrum of parotid disease in southern Africa has not previously been reported.
  • Pleomorphic adenoma was the most common benign tumour and metastatic cutaneous squamous cell carcinoma (SCC) was the most common malignancy.
  • Warthin's tumour had an equal gender distribution.
  • Forty-five per cent of parotid tumours in males were malignant.
  • CONCLUSIONS: In South African males almost half of parotid tumours are malignant.
  • Warthin's tumours are less common in Africa than in the West, and did not show a male preponderance.
  • [MeSH-major] Medical Audit. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • [CommentIn] S Afr J Surg. 2007 Nov;45(4):152; author reply 152 [18069585.001]
  • (PMID = 17892188.001).
  • [ISSN] 0038-2361
  • [Journal-full-title] South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie
  • [ISO-abbreviation] S Afr J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] South Africa
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78. Steele NP, Sampogna D, Sessions RB: Kaposi's sarcoma of an intraparotid lymph node leading to a diagnosis of HIV. Laryngoscope; 2005 May;115(5):861-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • If a patient is known to be HIV-positive, however, Kaposi's sarcoma must be considered in the differential diagnosis of salivary gland masses in addition to the benign and malignant neoplasms that occur in immunocompetent patients.
  • We present a unique case in which an otherwise healthy patient was diagnosed with HIV after resection of his enlarged parotid gland revealed Kaposi's sarcoma.
  • METHODS: A 58-year-old man presented with slowly enlarging bilateral parotid masses of approximately 3 years' duration.
  • RESULTS: A magnetic resonance imaging scan of the neck showed two right parotid lesions and one left parotid mass.
  • The patient underwent a right superficial parotidectomy for a suspected diagnosis of Warthin's tumor, given the bilaterality of the lesions.
  • Previously reported cases include salivary gland Kaposi's sarcoma in known HIV-positive patients and a handful of reports in patients without confirmed immunocompromise.
  • The patient presented here is unique because the diagnosis of parotid gland Kaposi's sarcoma led to a new diagnosis of HIV.
  • This interesting case reiterates the need for complete history taking and the inclusion of Kaposi's sarcoma in the differential diagnosis of salivary gland masses in the appropriate patient population.
  • [MeSH-major] HIV Seropositivity / diagnosis. Parotid Neoplasms / diagnosis. Sarcoma, Kaposi / diagnosis
  • [MeSH-minor] Adenolymphoma / diagnosis. Biopsy, Needle. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 15867654.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Burgess AN, Serpell JW: Parotidectomy: preoperative investigations and outcomes in a single surgeon practice. ANZ J Surg; 2008 Sep;78(9):791-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The aim of this study was to assess the value of fine-needle aspiration cytology (FNAC) as a preoperative evaluation for parotid tumours.
  • METHODS: Prospectively collected data on 77 patients, collected on a parotid database, were retrospectively analysed.
  • RESULTS: The most common histopathology was benign lesions (89.6%), including pleomorphic adenoma (55.8%) and Warthin's tumour (11.7%).
  • This confirms the usefulness of FNAC as a preoperative assessment of parotid masses.
  • [MeSH-major] Parotid Diseases / pathology. Parotid Gland / pathology. Parotid Gland / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Female. Humans. Male. Middle Aged. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery. Preoperative Care. Retrospective Studies. Treatment Outcome

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  • [CommentIn] ANZ J Surg. 2010 Mar;80(3):198-9 [20575936.001]
  • (PMID = 18844910.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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80. Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK: CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. Genes Chromosomes Cancer; 2007 Jul;46(7):708-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior.
  • We analyzed 55 primary salivary gland tumors including 22 mucoepidermoid carcinomas (MECs) to determine the association of MECT1/TORC1/CRTC1-MAML2 fusion transcript to tumor types, level of MEC differentiation and clinicopathologic parameters.
  • Our primary salivary gland tumors were composed of 22 MECs, 11 Warthin's tumors, 10 adenoid cystic carcinomas, two basaloid carcinomas, five salivary duct carcinomas, and five adenocarcinomas, not otherwise specified.
  • We also included, for the first time, three primary MECs of the thyroid gland.
  • Four (36%) of the 11 Warthin's tumors were also positive for the transcript.
  • None of the 22 primary non-MEC gland salivary carcinomas were positive for the transcript.
  • We conclude that the CRTC1/MAML2 transcript may be detected in both low and high grade MEC, that fusion negative tumors may define a subset of biologically aggressive MEC's tumors, that the fusion is present in primary MECs of the thyroid gland and is also detectable in Warthin's tumor, and that a subset of MECs can be targeted for therapeutic intervention.
  • [MeSH-major] Adenolymphoma / genetics. Carcinoma, Mucoepidermoid / genetics. DNA-Binding Proteins / genetics. Nuclear Proteins / genetics. RNA, Messenger / genetics. Salivary Gland Neoplasms / genetics. Thyroid Neoplasms / genetics. Transcription Factors / genetics

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  • (PMID = 17437281.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / Recombinant Fusion Proteins; 0 / Transcription Factors
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81. O'Neill ID: t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma. Oral Oncol; 2009 Jan;45(1):2-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This translocation is also found in Warthin's tumour and clear cell hidradenoma of the skin.
  • The CRTC1-MAML2 oncogene acts as a transcription factor on Notch and CREB regulatory pathways, disrupting normal cell-cycle and differentiation, contributing to tumour development.
  • [MeSH-major] Carcinoma, Mucoepidermoid / genetics. Lung Neoplasms / genetics. Oncogene Proteins, Fusion / genetics. Salivary Gland Neoplasms / genetics. Translocation, Genetic / genetics
  • [MeSH-minor] Adenolymphoma / genetics. Cell Cycle / genetics. Cell Line, Tumor. Chromosomes, Human, Pair 11 / genetics. Chromosomes, Human, Pair 19 / genetics. DNA-Binding Proteins / genetics. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Nuclear Proteins / genetics. Transcription Factors / genetics

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  • (PMID = 18486532.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / Transcription Factors
  • [Number-of-references] 77
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82. Röser K, Jäkel KT, Bullerdiek J, Löning T: [Significance of molecular-cytogenetic findings in mucoepidermoid carcinoma as an example of salivary gland tumors]. Pathologe; 2005 Sep;26(5):359-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Significance of molecular-cytogenetic findings in mucoepidermoid carcinoma as an example of salivary gland tumors].
  • Pending the elucidation of the t(11;19) at the molecular level of an apparently identical chromosomal translocation in Warthin's tumor, the identification of the translocation in MEC by FISH- and/or RT-PCR-analyses may become important in diagnosis and might have prognostic relevance.
  • Warthin's tumors are benign salivary gland neoplasms with a distinctive histomorphology and histogenesis completely different from MEC.
  • [MeSH-major] Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / pathology. Chromosome Aberrations. Salivary Gland Neoplasms / genetics. Translocation, Genetic

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  • (PMID = 16075259.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
  • [Number-of-references] 27
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83. Hernando M, Martín-Fragueiro L, Eisenberg G, Echarri R, García-Peces V, Urbasos M, Plaza G: [Surgical management of salivary gland tumours]. Acta Otorrinolaringol Esp; 2009 Sep-Oct;60(5):340-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical management of salivary gland tumours].
  • [Transliterated title] Tratamiento quirúrgico de los tumores de glándulas salivales.
  • INTRODUCTION AND OBJECTIVES: Salivary gland tumours account for 3% of head and neck tumours.
  • We reviewed their clinical characteristics, imaging findings, fine-needle cytology results, surgical charts (sub-maxillectomies, parotidectomies, palatal tumour excisions and cervicotomies), final pathology findings, and course with at least one year follow-up.
  • RESULTS: Forty-nine salivary tumours were treated, including 43 parotid tumours (87%), 3 sub-mandibular tumours (6%), 1 palatal tumour (2%) and 2 ectopic tumours (4%).
  • CONCLUSIONS: Parotid tumours are the most common salivary gland tumours.
  • Most of them are benign, but Warthin's tumour is more frequent than usual in our series.
  • [MeSH-major] Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Parotid Neoplasms / surgery. Postoperative Complications / epidemiology. Retrospective Studies. Young Adult

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  • (PMID = 19814986.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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84. Dalpa E, Gourvas V, Baritaki S, Miyakis S, Samaras V, Barbatis C, Sourvinos G, Spandidos DA: High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland. J Clin Virol; 2008 Jun;42(2):182-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland.
  • BACKGROUND: Warthin's tumor is a common benign neoplasm of the salivary gland.
  • Human Herpes Virus 8 (HHV-8) is the etiologic agent for all forms of Kaposi's sarcoma (KS), and HHV-8 DNA is present in saliva, suggesting that non-sexual transmission is associated with latent infection of the salivary gland.
  • OBJECTIVES: To provide insights into the HHV-8 cell tropism, the presence of HHV-8 was investigated in a series of Warthin's tumors of the salivary gland and corresponding adjacent normal tissue.
  • STUDY DESIGN: Forty-three patients with Warthin's tumors (cystadenolymphoma) were tested for the presence of HHV-8 DNA, and corresponding adjacent normal tissue samples were obtained from 15 patients.
  • RESULTS: HHV-8 DNA was detected in 19 out of 43 (44%) salivary gland tumor samples.
  • Among the 15 cases with paired samples, 9 were HHV-8-positive for both samples, 4 were HHV-8-negative for both samples while in two cases HHV-8 was detected only in the tumor specimens.
  • Larger studies are required to investigate the role of HHV-8 in the development or progression of Warthin's tumors.
  • [MeSH-major] Adenolymphoma / virology. Herpesvirus 8, Human / isolation & purification. Salivary Gland Neoplasms / virology. Salivary Glands / virology

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  • (PMID = 18339579.001).
  • [ISSN] 1386-6532
  • [Journal-full-title] Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • [ISO-abbreviation] J. Clin. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Viral
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85. Guntinas-Lichius O, Klussmann JP, Wittekindt C, Stennert E: Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. Laryngoscope; 2006 Apr;116(4):534-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations.
  • OBJECTIVE/HYPOTHESIS: The objective of this study was to analyze the perioperative and long-term complications after standardized lateral and total parotidectomy for benign parotid tumors and chronic parotitis with special regard on the training skill of the surgeons at a university teaching center.
  • First recurrence for pleomorphic adenoma was observed in 2% and for Warthin's tumor in 3%.
  • CONCLUSIONS: Standardized education in lateral and total parotidectomy for treatment of benign parotid disease under precise microscopic control is safe, demonstrates good results, and has low perioperative and long-term morbidity.
  • [MeSH-major] Hospitals, University / statistics & numerical data. Oral Surgical Procedures. Parotid Diseases / surgery. Parotid Gland / surgery

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  • (PMID = 16585855.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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86. Al Salamah SM, Khalid K, Khan IA, Gul R: Outcome of surgery for parotid tumours: 5-year experience of a general surgical unit in a teaching hospital. ANZ J Surg; 2005 Nov;75(11):948-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome of surgery for parotid tumours: 5-year experience of a general surgical unit in a teaching hospital.
  • BACKGROUND: Most of the recent reports on the surgical management of parotid gland disorders come from specialist divisions of otolaryngology, head and neck, or faciomaxillary surgery.
  • The aim of the present study was to evaluate the outcome of surgery for parotid tumours in a general surgical unit of a teaching hospital.
  • METHOD: A prospective clinicopathological study was undertaken over a 5-year period for consecutive patients operated on for parotid gland tumours in the King Saud University Unit of Riyadh Medical Complex.
  • RESULTS: Thirty seven parotid operations were performed on 36 consecutive patients.
  • All patients presented with parotid gland swelling.
  • Warthin's tumour was more common among male patients and was the only pathology with bilateral involvement.
  • Malignant tumour was found in five patients (13.5%).
  • CONCLUSION: Parotid gland surgery can still be performed in a general surgery unit with comparable outcome.
  • However, the operation should be performed in units with special interest and experience in surgery for parotid gland disorders.
  • [MeSH-major] Parotid Neoplasms / surgery

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  • (PMID = 16336383.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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87. Chakrabarti S, Bera M, Bhattacharya PK, Chakrabarty D, Manna AK, Pathak S, Maiti K: Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry. J Indian Med Assoc; 2010 Dec;108(12):833-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry.
  • Salivary gland swelling is a common and important problem.
  • Acute and chronic sialadenitis, different benign and malignant neoplasms are the common causes which present with salivary gland swelling.
  • Pre-operative core needle biopsy is hazardous and may damage facial nerve, lead to fistula formation or associated with tumour seeding.
  • The study was done with 40 cases of salivary gland swelling.
  • Out of 40 cases, 25 involved the parotid gland, most common age group affected was 20 - 40 years and male: female ratio was 5: 3.
  • One case of Warthin's tumour was cytologically diagnosed as pleomorphic adenoma.
  • FNAC is an important tool for early diagnosis of salivary gland lesions.
  • [MeSH-major] Biopsy, Fine-Needle. Salivary Gland Diseases / pathology

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  • (PMID = 21661459.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] India
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88. Lee YY, Wong KT, King AD, Ahuja AT: Imaging of salivary gland tumours. Eur J Radiol; 2008 Jun;66(3):419-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of salivary gland tumours.
  • Salivary gland neoplasms account for <3% of all tumors.
  • Most of them are benign and parotid gland is the commonest site.
  • As a general rule, the smaller the involved salivary gland, the higher is the possibility of the tumor being malignant.
  • The role of imaging in assessment of salivary gland tumour is to define intra-glandular vs. extra-glandular location, detect malignant features, assess local extension and invasion, detect nodal metastases and systemic involvement.
  • For lesions in the superficial parotid and submandibular gland, ultrasound is an ideal tool for initial assessment.
  • If deep tissue extension is suspected or malignancy confirmed on cytology, an MRI or CT is mandatory to evaluate tumour extent, local invasion and perineural spread.
  • For all tumours in the sublingual gland, MRI should be performed as the risk of malignancy is high.
  • For lesions of the deep lobe of parotid gland and the minor salivary glands, MRI and CT are the modalities of choice.
  • Ultrasound has limited visualization of the deep lobe of parotid gland which is obscured by the mandible.
  • Minor salivary gland lesions in the mucosa of oral cavity, pharynx and tracheo-bronchial tree, are also not accessible by conventional ultrasound.
  • Recent study suggests that MR spectroscopy may differentiate malignant and benign salivary gland tumours as well as distinguishing Warthin's tumor from pleomorphic adenoma.
  • Similarly, the role of nuclear medicine and PET scan, in imaging of parotid masses is limited.
  • Sialography is used to delineate the salivary ductal system and has limited role in assessment of tumour extent.
  • [MeSH-major] Diagnostic Imaging. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 18337041.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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89. Suzuki K, Iwai H, Kaneko T, Sakaguchi M, Hoshino S, Inaba M: Induction of parotitis by fine-needle aspiration in parotid Warthin's tumor. Otolaryngol Head Neck Surg; 2009 Aug;141(2):282-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Induction of parotitis by fine-needle aspiration in parotid Warthin's tumor.
  • OBJECTIVES: To estimate parotitis caused by fine-needle aspiration (FNA) in parotid Warthin tumor.
  • SETTING: Hospital records were reviewed for 104 parotid tumors (103 patients) including 35 Warthin tumors, which underwent FNA within our department.
  • RESULTS: Three patients with four Warthin tumors among them noticed parotid pain, swelling, and abscess formation as a consequence of acute parotitis after FNA.
  • Examinations of the materials obtained from tumor puncture or drainage before the start of antibiotic therapy showed no bacterial association in any patient.
  • Two of the patients with Warthin tumor underwent parotidectomy, and the surgical specimens indicated histopathological changes with necrosis, abscess, granuloma, and the infiltration of inflammatory cells including Langhans-type multinucleated giant cells.
  • CONCLUSIONS: It is conceivable that Warthin tumor bears the characteristics of inflammation induced by the FNA procedure without any relation to infection.
  • Therefore, it may be better to avoid routine FNA and give priority to diagnostic imagings over FNA in the diagnosis of tumors strongly suspected as Warthin tumor.
  • [MeSH-major] Adenolymphoma / complications. Biopsy, Fine-Needle / adverse effects. Parotid Neoplasms / complications. Parotitis / etiology

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  • (PMID = 19643266.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Wierzbicka M, Kopeć T, Szyfter W, Bem G: [Epidemiology of non-malignant salivary gland tumours based on 675 cases]. Otolaryngol Pol; 2010 Sep-Oct;64(5):281-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Epidemiology of non-malignant salivary gland tumours based on 675 cases].
  • About 80% of all tumours of salivary glands is located in parotid gland, from 10 to 20% - in submandibular gland and several percent in sublingual and small salivary gland.
  • This work aims at the assessment of the frequency of occurrence of non-malignant neoplasm in parotid and submandibular gland based on the material collected at the ENT Department of the Medical University in Poznan in the years 1995-2006.
  • Main aim of this work has been achieved through the execution of partial steps: the analysis of the trends in occurrence of non-malignant neoplasm in the 12-year period, the analysis of the epidemiological differences: sex, age, place of residence - town or country, duration of symptoms, diameter of the tumour at the time the patient reported for treatment, histological structures that were carried on the basis of the comparison of data collected in the two periods of time: period I--the years 1995-2000 and period II--the years 2001-2006.
  • In both periods the most frequent benign tumour was the mixed tumour (54.9% of all tumours) and constituted 60% and 54% of all tumours in the respective periods analyzed.
  • The next most frequently occurring tumour was Warthin's tumour, identified in 31.2% of the patients, in 23% in period I and 35% in period II.
  • Duration of the symptoms, ranged from 1 month to 20 years, 14 months on average, yet in 263 cases the tumour has been developing developed for over a year.
  • [MeSH-major] Rural Population / statistics & numerical data. Salivary Gland Diseases / epidemiology. Salivary Gland Diseases / pathology. Urban Population / statistics & numerical data
  • [MeSH-minor] Adult. Age Distribution. Age Factors. Aged. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Prognosis. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology. Young Adult

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  • (PMID = 21166137.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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91. Fiorella R, Di Nicola V, Fiorella ML, Spinelli DA, Coppola F, Luperto P, Madami L: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):182-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Major salivary gland diseases. Multicentre study.
  • This multicentre study involved 28 Italian ORL Centres responding to a questionnaire sent by us which allowed recruitment of a high large number of cases of parotid neoplasms observed over a 10-year period.
  • Benign tumours account for 80% of case histories with a relationship 1:4 M/F, the most frequent being pleomorphic adenoma (57.3% of cases), followed by Warthin's tumour (32.4%), this rating not having been confirmed in case histories (8-10%) in the literature.
  • When no clinically evident lymph nodes were present (NO) considering the tumour histotype, two thirds of patients underwent surgery or radiotherapy, while in the remainder the wait-and-see attitude was prefered.
  • [MeSH-major] Salivary Gland Neoplasms

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  • [ErratumIn] Acta Otorhinolaryngol Ital. 2005 Oct;25(5):following 337
  • (PMID = 16450775.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639866
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92. Basu S, Houseni M, Alavi A: Significance of incidental fluorodeoxyglucose uptake in the parotid glands and its impact on patient management. Nucl Med Commun; 2008 Apr;29(4):367-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Significance of incidental fluorodeoxyglucose uptake in the parotid glands and its impact on patient management.
  • BACKGROUND AND OBJECTIVES: Minimal-to-low grade fluorodeoxyglucose (FDG) uptake in the parotid glands is regarded as a normal variant in a whole-body survey with FDG-PET.
  • Not frequently, however, a relatively intense or asymmetric FDG uptake is encountered in the parotid glands.
  • The aim of this study was to determine the causes and characteristics of this 'FDG accumulation of uncertain significance' in the parotid glands in patients without any known or suspected pathologies at the time of whole-body FDG-PET.
  • In addition, we also examined patients in whom there was no documented evidence of parotid pathology before FDG-PET scan and a suspicion of disease involvement was first raised in the reports in view of focal uptake in the FDG-PET images.
  • Only those cases with no earlier history of disease involvement of parotid gland or known parotid pathology before FDG-PET were selected for this analysis.
  • These patients were selected from a population of patients with a known malignancy elsewhere who underwent conventional whole-body FDG-PET or PET/CT for staging, disease viability assessment, or treatment monitoring purposes and had demonstrated varying patterns of FDG uptake (unilateral, bilateral, symmetric, or asymmetric) in the parotid glands.
  • FDG uptake in the parotid glands was reported to be of uncertain significance in the majority of these patients and further correlation was suggested in the PET reports.
  • The results of appropriate correlative investigations with MRI, low-dose nonenhanced attenuation CT images (based on PET/CT scans), and histopathology (in cases in which focal lesions were revealed by the anatomic imaging modalities and biopsy was performed) carried out subsequent to the FDG-PET scans were reviewed for a definitive conclusion with regard to the significance of the FDG uptake in the parotid glands in these patients.
  • The final diagnosis based upon histopathology revealed primary parotid tumors (e.g., Warthin's tumor and pleomorphic adenoma, which presented as FDG-avid parotid incidentaloma) or metastatic disease involvement.
  • [MeSH-major] Fluorodeoxyglucose F18 / pharmacokinetics. Parotid Gland / metabolism. Parotid Gland / radionuclide imaging. Salivary Gland Diseases / metabolism. Salivary Gland Diseases / radionuclide imaging

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  • (PMID = 18317302.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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93. Párraga-Linares L, Aguirre-Urízar JM, Berini-Aytés L, Gay-Escoda C: Papillary cystoadenoma lymphomatosum (Warthin-like) of minor salivary glands. Med Oral Patol Oral Cir Bucal; 2009 Nov;14(11):e597-600
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary cystoadenoma lymphomatosum (Warthin-like) of minor salivary glands.
  • Papillary cystadenoma lymphomatosum is a benign salivary gland tumor most frequently located in the parotid gland (Warthin's tumor).
  • Clinically, it manifests as a slow growing tumor, fluctuant on palpation due to its cystic morphology.
  • The treatment of choice is complete excision with wide tumor-free margins.
  • We present a 73-year-old female patient with an asymptomatic tumor of 8 years evolution in the right posterior area of the hard palate.
  • We performed surgical excision and a biopsy, which was reported as papillary cystadenoma lymphomatosum.
  • The lesion was re-operated, performing the excision with CO2 laser and including the periosteum to ensure complete resection of the tumor.
  • [MeSH-major] Adenolymphoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 19680204.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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94. Ito FA, Ito K, Vargas PA, de Almeida OP, Lopes MA: Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. Int J Oral Maxillofac Surg; 2005 Jul;34(5):533-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases.
  • Salivary gland tumors are uncommon and the microscopical features can be complex.
  • The majority of the cases occurred in the parotid gland (67.7%), followed by the minor salivary glands (22.8%) and submandibular gland (9.5%).
  • Among the minor salivary gland tumors, the palate was the most frequent location (67%).
  • Pleomorphic adenoma was the most frequent tumor representing 54.2% of all cases, followed by mucoepidermoid carcinoma (13.5%), Warthin's tumor (8.5%) and adenoid cystic carcinoma (7.9%).
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Brazil / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. Female. Humans. Male. Middle Aged. Neoplasms, Glandular and Epithelial / epidemiology. Palate / pathology. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Sex Factors. Submandibular Gland Neoplasms / epidemiology

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  • (PMID = 16053874.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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95. Yaşar H, Ozkul H, Verim A, Ilhan E, Kökten N, Dereci G: [An evaluation of parotid gland masses]. Kulak Burun Bogaz Ihtis Derg; 2007;17(2):70-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [An evaluation of parotid gland masses].
  • OBJECTIVES: We retrospectively evaluated patients who underwent surgery for parotid gland masses.
  • PATIENTS AND METHODS: A total of 50 patients (25 females, 25 males; mean age 48.5 years; range 18 to 76 years) who underwent surgery for parotid gland masses were evaluated with regard to age, sex, preoperative diagnostic methods, histopathologic diagnoses, and surgical techniques.
  • Histopathological diagnoses were benign in 33 patients (66%), malignant in nine patients (18%), and tumor-like pathologies in eight patients (16%), the most common being pleomorphic adenoma (n=28, 56%), Warthin's tumor (n=4, 8%), and squamous cell carcinoma (n=4, 8%).
  • Mortality occurred in one patient with metastasis to the parotid gland.
  • CONCLUSION: Superficial parotidectomy is the minimal surgery for parotid gland masses.
  • If the deep lobe of the gland is involved, total parotidectomy should be performed with preservation of the facial nerve.
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Parotid Diseases / epidemiology
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Aged. Carcinoma, Squamous Cell / epidemiology. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Parotid Neoplasms / diagnosis. Parotid Neoplasms / epidemiology. Parotid Neoplasms / etiology. Parotid Neoplasms / pathology. Parotid Neoplasms / therapy. Retrospective Studies. Turkey / epidemiology

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  • (PMID = 17527056.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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96. Ozcan C, Apa DD, Aslan G, Gülhan S, Görür K: Mycobacterium tuberculosis infection within parotid gland Warthin tumor. J Craniofac Surg; 2008 Nov;19(6):1561-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mycobacterium tuberculosis infection within parotid gland Warthin tumor.
  • Tuberculosis of the parotid gland is extremely unusual.
  • Tuberculosis comprises 2.5% to 10% of parotid gland lesions.
  • Two clinical forms of parotid gland tuberculosis infection exist.
  • The second is a chronic, slow-growing, painless, and firm parotid mass mimicking a neoplasm.
  • Most of these patients were diagnosed after parotid gland surgery and histopathologic evaluation.
  • Warthin tumor is a well-known benign neoplasm of the salivary glands.
  • It is the second most common tumor of the parotid gland.
  • Mycobacterium tuberculosis within Warthin tumor is also unusual.
  • Five cases with parotid gland tuberculosis within Warthin tumor were reported in the literature.
  • In this report, we present a new patient with parotid gland tuberculosis within the Warthin tumor.
  • This type parotid gland pathology is an extremely rare entity, and to the best of our knowledge, this is the second documented case using polymerase chain reaction.
  • We also discussed the possible mechanisms of development of infection within Warthin tumor.
  • [MeSH-major] Adenolymphoma / diagnosis. Parotid Diseases / diagnosis. Parotid Neoplasms / diagnosis. Tuberculosis, Oral / diagnosis

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  • (PMID = 19098552.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents; 0 / Contrast Media; 0 / DNA, Bacterial
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97. Cocco AE, MacLennan GT, Lavertu P, Wasman JK: Xanthogranulomatous sialadenitis: a case report and literature review. Ear Nose Throat J; 2005 Jun;84(6):369-70, 374
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report the case of a man with a parotid mass that exhibited features consistent with an inflammatory process on fine-needle aspiration biopsy.
  • Histologic examination of the resected specimen identified a xanthogranulomatous tissue reaction adjacent to a Warthin's tumor.
  • [MeSH-major] Granuloma / diagnosis. Parotid Neoplasms / diagnosis. Sialadenitis / diagnosis. Xanthomatosis / diagnosis

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  • (PMID = 16075862.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Elagoz S, Gulluoglu M, Yilmazbayhan D, Ozer H, Arslan I: The value of fine-needle aspiration cytology in salivary gland lesions, 1994-2004. ORL J Otorhinolaryngol Relat Spec; 2007;69(1):51-6
MedlinePlus Health Information. consumer health - Salivary Gland Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of fine-needle aspiration cytology in salivary gland lesions, 1994-2004.
  • OBJECTIVE: Fine-needle aspiration cytology (FNAC) of the salivary gland is a commonly accepted, sensitive and specific technique in the diagnosis of both neoplastic and nonneoplastic lesions of the salivary gland.
  • The aim of this study was to investigate the efficacy of FNAC of salivary gland lesions and to decide whether the radiologist could perform it or not.
  • METHODS: We aspirated 162 salivary gland lesions of 56 patients undergoing biopsy and excision.
  • RESULTS: In the present study, among the FNAC performed in 162 patients with salivary gland masses, 15 (9%) were inadequate, and the remaining 147 were diagnostic.
  • There was 1 false-positive result, in which a nonneoplastic lesion was misdiagnosed as a Warthin's tumor.
  • CONCLUSION: FNAC is a useful and reliable tool in the diagnosis of salivary gland masses when performed by a radiologist or a clinician.
  • [MeSH-major] Biopsy, Fine-Needle. Salivary Gland Diseases / diagnosis. Salivary Glands / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Salivary Gland Neoplasms / diagnosis. Sensitivity and Specificity

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17085953.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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99. Bandyopadhyay A, Das TK, Raha K, Hati GC, Mitra PK, Dasgupta A: A study of fine needle aspiration cytology of salivary gland lesions with histopathological corroboration. J Indian Med Assoc; 2005 Jun;103(6):312-4, 316
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A study of fine needle aspiration cytology of salivary gland lesions with histopathological corroboration.
  • The diagnostic utility of fine needle aspiration cytology as initial work up of salivary gland enlargement was assessed in one hundred and eighty-five salivary gland specimens over three years period and corroborated with histopathology, whenever feasible.
  • All smears were evaluated according to cell size, amount of cytoplasm, cytologic atypia and presence of lymphocytes. (a) Variable cytologic appearances of pleomorphic salivary adenoma were observed. (b) Cellular pleomorphic adenoma and adenoid cystic carcinoma showed basaloid cell features. (c) Tumours with intermediate size cells and bland cytology included low grade muco-epidermoid carcinoma and cystic lesions. (d) Warthin's tumour, oncocytoma, salivary duct carcinoma and high grade muco-epidermoid carcinoma revealed large cells and abundant cytoplasm with or without atypia.
  • So it can be concluded that fine needle aspiration cytology can play important role in early diagnosis and subsequent therapeutic planning of salivary gland lesions.
  • [MeSH-major] Adenoma / pathology. Salivary Gland Neoplasms / pathology. Sialadenitis / pathology

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  • (PMID = 16225156.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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100. Daniel E, McGuirt WF Sr: Neck masses secondary to heterotopic salivary gland tissue: a 25-year experience. Am J Otolaryngol; 2005 Mar-Apr;26(2):96-100
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neck masses secondary to heterotopic salivary gland tissue: a 25-year experience.
  • The benign tumors were predominantly Warthin's tumor (8) with 1 pleomorphic adenoma.
  • Among the 15 tumor patients, follow-up ranged from 1 month to 17 years.
  • Tumorigenic changes arise from heterotopic nodal inclusions, and although infrequent, should be considered in the differential diagnosis for isolated neck/periparotid masses and parotid Warthin's tumor.
  • Suggested management, after a thorough clinical exam/needle aspiration biopsy, includes an imaging survey of the parotid gland and neck lymphatics with an appropriate resection to include a simple excision, parotidectomy, neck dissection, and/or irradiation as indicated.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Choristoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands

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  • (PMID = 15742261.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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