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1. Ungari C, Paparo F, Colangeli W, Iannetti G: Parotid glands tumours: overview of a 10-year experience with 282 patients, focusing on 231 benign epithelial neoplasms. Eur Rev Med Pharmacol Sci; 2008 Sep-Oct;12(5):321-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenoma is the most common benign epithelial salivary gland neoplasm, comprising 50%-74% of all parotid tumours.
  • It is followed by Warthin's tumour (4-14%).
  • Smoking habit is important in Warthin's tumour pathogenesis.
  • Tumour pseudopodia and capsule ruptures are recognised factors involved in pleomorphic adenoma recurrences but also tumour multicentricity might play an important role.

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  • (PMID = 19024217.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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2. Gürbüz Y, Yildiz K, Aydin O, Almaç A: Immunophenotypical profiles of salivary gland tumours: a new evidence for their histogenetic origin. Pathologica; 2006 Apr;98(2):147-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 30 cases of salivary gland tumours (18 pleomorphic adenomas, 8 Warthin's tumours, 2 basal cell adenomas, 2 acinic cell carcinomas) were included in our study.
  • SMA was not detected in Warthin's tumour (p < 0.0001).
  • CK10 immunoreactivity was observed in 5 Warthin's tumour.
  • Immunophenotypic profile of Warthin's tumour is suggestive of an embryological remnant origin.
  • [MeSH-minor] Adenolymphoma / chemistry. Adenolymphoma / pathology. Adenoma / chemistry. Adenoma / pathology. Adenoma, Pleomorphic / chemistry. Adenoma, Pleomorphic / pathology. Carcinoma, Acinar Cell / chemistry. Carcinoma, Acinar Cell / pathology. Humans. Immunophenotyping. Organ Specificity. Protein Isoforms / analysis. Retrospective Studies

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  • (PMID = 16929788.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Actins; 0 / Neoplasm Proteins; 0 / Protein Isoforms; 68238-35-7 / Keratins
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3. Faur A, Lazăr E, Cornianu M, Dema A, Vidita CG, Găluşcan A: Warthin tumor: a curious entity--case reports and review of literature. Rom J Morphol Embryol; 2009;50(2):269-73
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  • [Title] Warthin tumor: a curious entity--case reports and review of literature.
  • Warthin tumor was first described in the American literature, by Aldred Warthin, in 1929, the pathologist who named this tumor papillary cystadenoma lymphomatosum, but since than it was also knew as adenolymphoma, cystadenolymphoma, and Warthin tumor.
  • Because of its microscopically appearance and unknown origin, this tumor entity is still fascinating head and neck surgeons and pathologist.
  • We evaluate the histopathological aspect of Warthin tumors using Hematoxylin-Eosin stain, and immunohistochemical and histological techniques.
  • We reviewed the medical record of patients with salivary gland tumors diagnosed at County Hospital of Timisoara from 2002-2008.
  • In six years, 22 cases with Warthin tumor were diagnosed and among them 17 men and five women, with average age 58.47.
  • The analysis showed that 77.27% of Warthin tumors occurred in men, and the main histopathological aspect was with 50% epithelial component.
  • The standard and the histological and immunohistochemical techniques highlighted the complex and variable microscopical appearance of Warthin tumor that the pathologist should consider when a diagnosis for this tumor is to be considered.
  • [MeSH-major] Adenolymphoma / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 19434322.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Mucins
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4. Schapher M, Wendler O, Gröschl M, Schäfer R, Iro H, Zenk J: Salivary leptin as a candidate diagnostic marker in salivary gland tumors. Clin Chem; 2009 May;55(5):914-22
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  • [Title] Salivary leptin as a candidate diagnostic marker in salivary gland tumors.
  • The aim of this study was to investigate the expression of leptin and its receptors Ob-Ra and Ob-Rb in parotid salivary gland tumors, with particular regard to a potential use of leptin as a tumor marker.
  • METHODS: Parotid tissue samples from healthy individuals (n = 31) and tumor patients (n = 97, including tissue samples from pleomorphic adenomas, adenolymphomas, basal cell adenomas, and diverse carcinomas) were analyzed by use of ApoTome-technique microscopy, immunohistochemistry, immunofluorescence, immunoblotting, and quantitative real-time PCR.
  • Ultrasound was used to determine tumor size before surgery.
  • RESULTS: In all salivary gland tumors leptin was expressed in much higher amounts than in healthy parotid tissues.
  • The cytokine was not imported from the blood but actively produced by the tumors.
  • Furthermore, the examined tumors overexpressed the receptor isoforms Ob-Ra and Ob-Rb.
  • Measured leptin concentrations in mixed saliva samples were significantly increased in patients with parotid tumors [mean (SD) 673 (484) pg/mL in pleomorphic adenomas, 679 (465) pg/mL in adenolymphomas, and 880 (618) pg/mL in carcinomas] vs controls [125 (36) pg/mL] (P < 0.001).
  • CONCLUSIONS: This is the first study to show that the analysis of salivary leptin in mixed saliva samples may allow preoperative differentiation between tumor patients and healthy individuals.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Leptin / biosynthesis. Parotid Neoplasms / metabolism. Salvia / metabolism
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenolymphoma / metabolism. Adenolymphoma / pathology. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Adiponectin / biosynthesis. Adiponectin / genetics. Adolescent. Adult. Aged. Aged, 80 and over. Blotting, Western. Enzyme-Linked Immunosorbent Assay. Female. Fluorescent Antibody Technique, Indirect. Humans. Immunohistochemistry. Male. Middle Aged. Polymerase Chain Reaction. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Receptors, Leptin / biosynthesis. Receptors, Leptin / genetics. Young Adult

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  • (PMID = 19299541.001).
  • [ISSN] 1530-8561
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ADIPOQ protein, human; 0 / Adiponectin; 0 / Biomarkers, Tumor; 0 / Leptin; 0 / RNA, Messenger; 0 / Receptors, Leptin; 0 / leptin receptor, human
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5. Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H: MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin Cancer Res; 2006 Jul 1;12(13):3902-7
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  • Mucoepidermoid carcinoma translocated gene 1-mastermind-like gene family (MECT1-MAML2) gene fusion was identified from a recurring t(11;19)(q21;p13) translocation, which is often the sole cytogenetic alteration in this disease.
  • EXPERIMENTAL DESIGN: Seventy-one cases of mucoepidermoid carcinoma and 51 cases of nonmucoepidermoid carcinoma salivary gland tumors (including 26 Warthin tumor cases) were retrospectively analyzed.
  • RESULTS: The MECT1-MAML2 fusion transcript was detected in 27 of the 71 (38%) mucoepidermoid carcinoma cases but not in any case of nonmucoepidermoid carcinoma tumors.
  • Detection of the MECT1-MAML2 fusion transcript was associated with a less advanced clinical stage and a low-grade tumor histology.
  • The presence of the transcript was associated with longer disease-free and overall survivals on univariate analysis and emerged as an independent prognostic factor for longer overall survival on multivariate analysis.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Disease-Free Survival. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic / genetics. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Retrospective Studies. Reverse Transcriptase Polymerase Chain Reaction / methods. Survival Rate

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  • [CommentIn] Clin Cancer Res. 2006 Jul 1;12(13):3878-81 [16818681.001]
  • (PMID = 16818685.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
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6. Reddy VM, Thangarajah T, Castellanos-Arango F, Panarese A: Conservative management of warthin tumour. J Otolaryngol Head Neck Surg; 2008 Oct;37(5):744-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative management of warthin tumour.
  • BACKGROUND: Warthin tumour (WT) is usually treated by surgery to establish a histologic diagnosis.
  • [MeSH-major] Adenolymphoma / pathology. Adenolymphoma / therapy. Biopsy, Fine-Needle / methods. Parotid Neoplasms / pathology. Parotid Neoplasms / therapy

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  • (PMID = 19128687.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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7. Yerli H, Aydin E, Coskun M, Geyik E, Ozluoglu LN, Haberal N, Kaskati T: Dynamic multislice computed tomography findings for parotid gland tumors. J Comput Assist Tomogr; 2007 Mar-Apr;31(2):309-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dynamic multislice computed tomography findings for parotid gland tumors.
  • OBJECTIVE: Our aim was to research the enhancement features of parotid gland masses in detail and characterize if the masses were Warthin tumors, adenomas, or malignant tumors.
  • METHODS: The prospective study included 25 parotid tumors in 21 patients.
  • A full-neck CT examination was done at 30 seconds after completion of contrast injection, and then tumor-level images were obtained at 90 seconds and at 5 and 25 minutes.
  • Computed tomography number (lesion density in Hounsfield units) was determined at each phase, and differences within and among tumor groups were statistically analyzed.
  • RESULTS: There were 11 Warthin tumors, 8 pleomorphic adenomas, 5 malignant tumors, and 1 basal cell adenoma.
  • Ten Warthin tumors showed rapid contrast enhancement at 30 seconds and rapid reduction of enhancement from the first to the fourth phase.
  • The basal cell adenoma showed also a peak enhancement at 30 seconds.
  • Four malignant tumors showed peak enhancement at 90 seconds.
  • Statistically significant differences within and among tumor groups were determined.
  • CONCLUSIONS: The data suggest that peak tumor enhancement at 30 and 90 seconds, respectively, might identify Warthin and malignant tumors.
  • [MeSH-major] Adenolymphoma / diagnosis. Adenoma / diagnosis. Carcinoma / diagnosis. Lymphoma / diagnosis. Parotid Gland / radiography. Parotid Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 17414771.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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8. Arvanitis DL, Arvanitis LD, Panourias IG, Kitsoulis P, Kanavaros P: Mitochondria-rich normal, metaplastic, and neoplastic cells show overexpression of the epitope H recognized by the monoclonal antibody H. Pathol Res Pract; 2005;201(4):319-24
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  • Immunohistochemical staining for the mAbH was observed in oxyphil cells of parathyroid glands, in striated duct cells of parotid glands, in urinary tubules of kidneys, in parietal cells of gastric body mucosa, in oxyphil cells of Hashimoto's thyroiditis, in epithelial cells of Warthin's tumors of the parotid gland, in neoplastic cells of oxyphil adenomas and carcinomas (Hürthle's tumors) of the thyroid gland, and in neoplastic cells of oncocytomas of the kidneys.
  • These findings may be of interest for gaining insight into the histophysiology of mitochondria-rich normal cells and into the pathogenesis of oncocytic lesions, since O-GlcNAc glycosylation may modify proteins involved in oncogenesis such as tumor suppressor proteins and oncoproteins, as well as proteins with important biological functions such as cytoskeletal proteins, transcription factors, heat-shock proteins, and chromatin proteins.
  • [MeSH-minor] Antigens, Neoplasm / immunology. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / immunology. Biomarkers, Tumor / metabolism. Epitopes / immunology. Epitopes / metabolism. Fluorescent Antibody Technique, Indirect. Humans. Immunoenzyme Techniques. Metaplasia / immunology. Metaplasia / metabolism. Metaplasia / pathology

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  • (PMID = 15991839.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Epitopes; V956696549 / Acetylglucosamine
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9. Arida M, Barnes EL, Hunt JL: Molecular assessment of allelic loss in Warthin tumors. Mod Pathol; 2005 Jul;18(7):964-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular assessment of allelic loss in Warthin tumors.
  • Warthin's tumors are benign lesions of the head and neck that have a characteristic morphologic appearance.
  • The etiology of Warthin's tumors is controversial and whether they are true neoplasms or developmental malformations continues to be debated.
  • In this study, we examined 12 Warthin tumors with a molecular and immunohistochemical approach.
  • The epithelial and lymphoid components of each lesion were microdissected and PCR was performed for 13 microsatellite markers at or near common tumor suppressor genes.
  • The epithelial component of all tumors was negative for p53 and p16ink.
  • The immunohistochemical and molecular results in this study lend support to the hypothesis that Warthin tumors are non-neoplastic, as there was no evidence of aberrant staining for tumor suppressor gene protein products and no evidence of consistent clonal allelic losses.
  • [MeSH-major] Loss of Heterozygosity. Parotid Neoplasms / pathology. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Aged. Cyclin-Dependent Kinase Inhibitor p16 / analysis. DNA, Neoplasm / analysis. DNA, Neoplasm / genetics. Electrophoresis, Capillary. Female. Genotype. Humans. Immunohistochemistry. Male. Middle Aged. Tumor Suppressor Protein p53 / analysis. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 15861216.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins
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10. Kang M, Khandelwal N, Singh P, Choudhary S, Mukherjee KK: Imaging features of endolymphatic sac tumours: case report with review of literature. Australas Radiol; 2007 Dec;51 Suppl:B199-201
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  • Papillary endolymphatic sac tumours (ELSTs) are rare lesions of the temporal bone often confused with other more common entities.
  • [MeSH-major] Adenolymphoma / diagnosis. Skull Neoplasms / diagnosis. Temporal Bone / pathology. Temporal Bone / ultrasonography

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  • (PMID = 17991063.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 14
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11. Fehr A, Röser K, Belge G, Löning T, Bullerdiek J: A closer look at Warthin tumors and the t(11;19). Cancer Genet Cytogenet; 2008 Jan 15;180(2):135-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A closer look at Warthin tumors and the t(11;19).
  • The translocation t(11;19)(q21;p13) has been described in mucoepidermoid carcinoma (MEC) and rarely in Warthin tumors (WT), both tumors of the salivary gland.
  • On review, the two positive cases were classified as tumors highly suspect for MEC.
  • Indeed, our experience and published observations of the t(11;19)(q21;p13) translocation in WT reveal that only a small subset of WTs are positive, and that these tumors are often classified as infarcted or metaplastic WT, known to overlap considerably with MEC on purely morphological grounds.
  • [MeSH-major] Adenolymphoma / genetics. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. Salivary Gland Neoplasms / genetics. Translocation, Genetic
  • [MeSH-minor] Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / genetics. Cell Line, Tumor. DNA-Binding Proteins / genetics. Gene Expression Regulation, Neoplastic. Humans. Nuclear Proteins / genetics. Oncogene Proteins, Fusion / genetics. Transcription Factors / genetics

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  • (PMID = 18206539.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / Transcription Factors
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12. Song K, Cotelingam JD, Lowery-Nordberg M, Sun W: Characterization of the lymphoid stroma in Warthin's tumor of salivary gland by immunohistochemistry, heavy chain gene and Bcl-2 gene rearrangement. Am J Transl Res; 2009;1(4):352-7
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  • [Title] Characterization of the lymphoid stroma in Warthin's tumor of salivary gland by immunohistochemistry, heavy chain gene and Bcl-2 gene rearrangement.
  • Warthin's tumor is rarely associated with malignant lymphoma.
  • In most cases the latter is a low grade process, including Marginal zone/Mucosa associated lymphoid tissue (MALT) type lymphoma, follicular lymphoma, and rarely diffuse large cell lymphoma which may arise de novo or secondary to low grade lymphoma.
  • This study was conducted to determine the prevalence of occult B cell monoclones and genetic alterations in Warthin's tumor.
  • Fourteen cases of Warthin's tumor were stained with antibodies to CD3, CD20, kappa and lambda light chains.
  • On six cases of randomly selected Warthin's tumor, polymerase chain reaction (PCR) of IgH gene rearrangement (IgH-GR) was performed on genomic DNA extracted from formalin-fixed paraffin embedded tissue.
  • In all Warthin's tumor and sialadenitis cases most of lymphoid stroma was B cell phenotype and concentrated in germinal centers.
  • Our study concludes that the lymphoid stroma of Warthin's tumor is reactive.

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  • (PMID = 19956447.001).
  • [ISSN] 1943-8141
  • [Journal-full-title] American journal of translational research
  • [ISO-abbreviation] Am J Transl Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780035
  • [Keywords] NOTNLM ; Warthin's tumor / gene rearrangement / immunohistochemistry / lymphoid stroma
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13. Yaşar H, Ozkul H, Verim A, Ilhan E, Kökten N, Dereci G: [An evaluation of parotid gland masses]. Kulak Burun Bogaz Ihtis Derg; 2007;17(2):70-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histopathological diagnoses were benign in 33 patients (66%), malignant in nine patients (18%), and tumor-like pathologies in eight patients (16%), the most common being pleomorphic adenoma (n=28, 56%), Warthin's tumor (n=4, 8%), and squamous cell carcinoma (n=4, 8%).
  • Nine patients with malignant tumors also had neck dissection and postoperative radiotherapy.
  • In malignant tumors, neck dissection and postoperative radiotherapy should be added.
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Aged. Carcinoma, Squamous Cell / epidemiology. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Parotid Neoplasms / diagnosis. Parotid Neoplasms / epidemiology. Parotid Neoplasms / etiology. Parotid Neoplasms / pathology. Parotid Neoplasms / therapy. Retrospective Studies. Turkey / epidemiology

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  • (PMID = 17527056.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
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14. Suwała P, Wilczyński K, Barnaś S, Prudlak E: [A rare case of multiple primary benign neoplasm of parotid gland: oncocytoma and adenolimphoma]. Otolaryngol Pol; 2009 Sep;63(7):89-92
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  • AIM OF THE WORK: The authors present unusually rare case primary multiple synchronicus benign tumor of the ipsilateral parotid gland: oncocytoma and Warthin's tumor, which is rare among occasionally occurred multiple tumors with different histology in the salivary glands.
  • MATERIAL AND METHOD: A 71-year-old man presented with the tumor in the right parotid gland.
  • The preoperative ultrasonography and macroscopic analysis of the removed parotid gland tissue revealed only one tumor recognised histopathologically as adenolimphoma, but upon histopathological examination Warthin's tumor proved to coexist with oncocytoma.
  • RESULTS AND CONCLUSIONS: In the ultrasonography examination some salivary glands tumors may not be recognised.
  • The histopathological examination is the ultimate method in recognising tumors, which are not detected in the preoperative diagnosis.
  • The superficial parotidectomy protects from the recrudescence of the superficial lobe of the parotid gland tumors.
  • The coexistence of the oncocytoma and Warthin's in one parotid gland is extremely rare.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Oxyphilic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 20564910.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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15. Yu Q, Yang J, Wang P, Shi H, Luo J: Preliminary assessment of benign maxillofacial and neck lesions with in vivo single-voxel 1H magnetic resonance spectroscopy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Aug;104(2):264-70
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  • On the PRESS, 8 out of 11 (72.7%) neurogenic tumors, 5 of 7 (71.5%) Warthin tumors, and 4 of 5 (80%) sarcoidosis and sinus histiocytosis were detected with Cho signals, whereas 16 of 19 (84.2%) fluid-filled lesions (hemangiomas, lymphangiomas, and cysts) had no Cho signals.
  • Most neurogenic tumors, Warthin tumors, sarcoidosis, and sinus histiocytosis were detected with Cho signals.
  • [MeSH-minor] Adenolymphoma / diagnosis. Adolescent. Adult. Aged. Choline / metabolism. Cysts / chemically induced. Female. Hemangioma / diagnosis. Histiocytosis / diagnosis. Humans. Lymphangioma / diagnosis. Magnetic Resonance Spectroscopy. Male. Middle Aged. Neoplasms, Nerve Tissue / diagnosis. Protons. Sarcoidosis / diagnosis

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  • (PMID = 17630099.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons; N91BDP6H0X / Choline
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16. Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H, Griffin JD: Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. EMBO J; 2005 Jul 6;24(13):2391-402
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  • Salivary gland tumors, a group of histologically diverse benign and malignant neoplasms, represent a challenging problem for diagnosis and treatment.
  • A specific recurring t(11;19)(q21;p13) translocation is associated with two types of salivary gland tumors, mucoepidermoid carcinomas and Warthin's tumors.
  • This study has identified a novel, critical mechanism of transformation for an oncogene associated very specifically with salivary gland tumors, and identified potential targets for the development of novel therapies.

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  • (PMID = 15961999.001).
  • [ISSN] 0261-4189
  • [Journal-full-title] The EMBO journal
  • [ISO-abbreviation] EMBO J.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA036167; United States / NCI NIH HHS / CA / R01 CA097148; United States / NCI NIH HHS / CA / R37 CA036167
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CREB1 protein, human; 0 / Cyclic AMP Response Element-Binding Protein; 0 / MECT1-MAML2 fusion protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / Trans-Activators; 0 / Transcription Factors; E0399OZS9N / Cyclic AMP
  • [Other-IDs] NLM/ PMC1173159
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17. Foschini MP, Gaiba A, Cocchi R, Pennesi MG, Pession A: p63 expression in salivary gland tumors: role of DeltaNp73L in neoplastic transformation. Int J Surg Pathol; 2005 Oct;13(4):329-35
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  • [Title] p63 expression in salivary gland tumors: role of DeltaNp73L in neoplastic transformation.
  • To illustrate the role of p63 and its truncated variants in salivary gland tumors, 23 consecutive tumors and 6 normal salivary glands were studied immunohistochemically with anti-p63 antibody and by reverse transcriptase (RT) and nested polymerase chain reaction (PCR) to detect p63 isoform expression.
  • Tumors: p63 antibody was positive in the following: Warthin tumor (WT) (3/3), oncocytoma (OC) (1/1), pleomorphic adenoma (PA) (7/7), polymorphous-low-grade adenocarcinoma (PLGA) (3/3), adenoid-cystic carcinoma (ADCC)(3/4), epithelial-myoepithelial-cell carcinoma (EMC) (1/1), and myoepithelial-cell carcinoma (MCC) (1/1).
  • By RT and nested PCR all tumors expressed p63 irrespective of their morphologic differentiation.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenolymphoma / metabolism. Adenolymphoma / pathology. Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Adult. Aged. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cell Proliferation. DNA-Binding Proteins. Exons. Female. Gene Expression Regulation, Neoplastic. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Male. Middle Aged. Myoepithelioma / metabolism. Myoepithelioma / pathology. Polymerase Chain Reaction. Protein Isoforms. Reverse Transcriptase Polymerase Chain Reaction. Salivary Glands / cytology. Salivary Glands / metabolism. Salivary Glands / pathology. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 16273188.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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18. Giaslakiotis K, Androulaki A, Panagoulias G, Kyrtsonis MC, Lazaris AC, Kanakis DN, Patsouris ES: T cell lymphoblastic lymphoma in parotidectomy for Warthin's tumor: case report and review of the literature. Int J Hematol; 2009 Apr;89(3):359-64
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  • [Title] T cell lymphoblastic lymphoma in parotidectomy for Warthin's tumor: case report and review of the literature.
  • Lymphomas associated with Warthin's tumor (WT) are extremely uncommon and the majorities are of B cell type.
  • Staging investigations revealed mediastinal and abdominal lymphadenopathy, bilateral pleural effusions and bone marrow infiltration, in keeping with stage IVB disease.
  • [MeSH-major] Adenolymphoma / pathology. Adenolymphoma / surgery. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell / surgery. Parathyroidectomy. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery

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  • (PMID = 19294485.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD
  • [Number-of-references] 19
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19. Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK: CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. Genes Chromosomes Cancer; 2007 Jul;46(7):708-15
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  • [Title] CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior.
  • We analyzed 55 primary salivary gland tumors including 22 mucoepidermoid carcinomas (MECs) to determine the association of MECT1/TORC1/CRTC1-MAML2 fusion transcript to tumor types, level of MEC differentiation and clinicopathologic parameters.
  • Our primary salivary gland tumors were composed of 22 MECs, 11 Warthin's tumors, 10 adenoid cystic carcinomas, two basaloid carcinomas, five salivary duct carcinomas, and five adenocarcinomas, not otherwise specified.
  • Significant correlation between fusion negative tumors and distant metastasis was noted (P = 0.005).
  • Four (36%) of the 11 Warthin's tumors were also positive for the transcript.
  • We conclude that the CRTC1/MAML2 transcript may be detected in both low and high grade MEC, that fusion negative tumors may define a subset of biologically aggressive MEC's tumors, that the fusion is present in primary MECs of the thyroid gland and is also detectable in Warthin's tumor, and that a subset of MECs can be targeted for therapeutic intervention.
  • [MeSH-major] Adenolymphoma / genetics. Carcinoma, Mucoepidermoid / genetics. DNA-Binding Proteins / genetics. Nuclear Proteins / genetics. RNA, Messenger / genetics. Salivary Gland Neoplasms / genetics. Thyroid Neoplasms / genetics. Transcription Factors / genetics

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  • (PMID = 17437281.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / Recombinant Fusion Proteins; 0 / Transcription Factors
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20. Yerli H, Avci S, Aydin E, Arikan U: The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Mar;109(3):e95-8
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  • [Title] The metaplastic variant of Warthin tumor of the parotid gland: dynamic multislice computerized tomography and magnetic resonance imaging findings with histopathologic correlation in a case.
  • Metaplastic Warthin tumor is a rarely seen subtype of Warthin tumor.
  • Making a diagnosis can become easier by knowing this entity of Warthin tumor well and by correlating the radiologic findings with pathology.
  • In this case presentation, imaging features of a metaplastic Warthin tumor are presented together with its histopathologic findings.
  • When a solid mass with peripheral enhancing cystic-necrotic component and well defined contour and capsule that shows early enhancement and washout is identified with imaging methods in parotid gland, metaplastic Warthin tumor should be indicated in the differential diagnosis before the histopathologic evaluation.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 19969491.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Castelino-Prabhu S, Li QK, Ali SZ: Nonsebaceous lymphadenoma of the parotid gland: cytopathologic findings and differential diagnosis. Diagn Cytopathol; 2010 Feb;38(2):137-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenolymphoma / pathology. Aged, 80 and over. Biopsy, Fine-Needle. Cholecystectomy. Diagnosis, Differential. Female. Humans. Hysterectomy. Pneumonectomy. Tonsillectomy

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  • (PMID = 19670220.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Guldfred LA, Becker BC, Eiholm S: [Multiple synchronous tumours of different histological type of the salivary glands]. Ugeskr Laeger; 2008 Apr 28;170(18):1571
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  • [Transliterated title] Multiple synkrone tumorer med forskellig histologi i de store spytkirtler.
  • Here we report a 72-year-old woman who was diagnosed with simultaneously occurring Warthin's tumour of the left parotid and mixed tumour of the homolateral submandibular gland.
  • This case also illustrates the importance of thorough examination even after the identification of a single tumour, as multiple synchronous primary tumours--even if rare--can be a diagnostic possibility.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 18454930.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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23. Motoori K, Ueda T, Uchida Y, Chazono H, Suzuki H, Ito H: Identification of Warthin tumor: magnetic resonance imaging versus salivary scintigraphy with technetium-99m pertechnetate. J Comput Assist Tomogr; 2005 Jul-Aug;29(4):506-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of Warthin tumor: magnetic resonance imaging versus salivary scintigraphy with technetium-99m pertechnetate.
  • OBJECTIVE: The aim of this study was to evaluate the accuracy of technetium-99m (Tc-99m) pertechnetate scintigraphy and magnetic resonance (MR) imaging in the diagnosis of Warthin tumor.
  • METHODS: Sixteen cases of Warthin tumor and 17 cases of non-Warthin tumor were examined by Tc-99m pertechnetate scintigraphy with lemon juice stimulation and MR imaging, including T1-weighted, T2-weighted, short inversion time inversion recovery, diffusion-weighted, and contrast-enhanced dynamic images.
  • RESULTS: The mean area under the ROC curves of MR imaging in the diagnosis of Warthin tumor (0.97) was higher than that of Tc-99m pertechnetate scintigraphy (0.88).
  • CONCLUSION: Magnetic resonance imaging is more useful in the evaluation of Warthin tumor than Tc-99m pertechnetate scintigraphy.
  • [MeSH-major] Adenolymphoma / pathology. Adenolymphoma / radionuclide imaging. Brain Neoplasms / pathology. Brain Neoplasms / radionuclide imaging. Salivary Glands / radionuclide imaging. Sodium Pertechnetate Tc 99m

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  • (PMID = 16012309.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] A0730CX801 / Sodium Pertechnetate Tc 99m
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24. Yu H, Liu D, Li C, Huang X, Zhong W: [Clinical application of postauricular muscular fasciae-periosteal flap and modified unwrinkle incision in parotidectomy]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2009 Oct;23(10):1167-9
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  • There were 17 males and 11 females aged 19 to 79 years old (average 50 years old), including 20 cases of mixed tumor, 5 cases of adenolymphoma, 1 case of branchial cleft cyst, 1 case of eosinophilic hyperplastic lymphogranuloma, and 1 case of myoepithelioma.
  • Tumor masses were all prominent, with the diameter of 2.4-3.8 cm and partial-tough texture.
  • The course of disease was 3-18 months (average 9.5 months).
  • Parotid gland and tumor mass were resected with postauricular incision hidden within the hairline, introcession defect (3.0 cm x 2.0 cm x 1.0 cm-3.5 cm x 2.5 cm x 1.5 cm) were repaired with simultaneously adopting postauricular muscular fasciae-periosteal flap (4.0 cm x 3.0 cm x 1.0 cm-5.0 cm x 4.0 cm x 1.5 cm) by turning the pedicle flap 180 degrees.

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  • (PMID = 19957830.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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25. Fogarty GB, Mok MT, Taranto A, Murray WK: Warthin's tumour, a rare false positive on positron emission tomography in melanoma staging. Acta Oncol; 2005;44(1):87-9
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  • [Title] Warthin's tumour, a rare false positive on positron emission tomography in melanoma staging.
  • [MeSH-major] Adenolymphoma / radionuclide imaging. Melanoma / radionuclide imaging. Positron-Emission Tomography / methods. Skin Neoplasms / radionuclide imaging

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  • (PMID = 15858864.001).
  • [ISSN] 0284-186X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
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26. Abd-Elhamid ES, Elshafei MM: Immunohistochemical localization of mdm-2, p27Kip1 and bcl-2 in Warthin's tumor of the parotid gland. Diagn Pathol; 2009;4:14
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  • [Title] Immunohistochemical localization of mdm-2, p27Kip1 and bcl-2 in Warthin's tumor of the parotid gland.
  • BACKGROUND: Warthin's tumor is a benign monomorphic adenoma with unclear origin that almost occur exclusively in the parotid gland.
  • Etiology of Warthin's tumor as well as its malignant potential are still unclear.
  • Therefore immunohistochemical assessment of Warthin's tumor may be useful to detect its origin or its malignant transformation potential.
  • AIMS AND OBJECTIVES: The present study aims to investigate the immunohistochemical expression of murine double minute-2 (mdm-2), p27Kip1 and B cell lymphoma-2 (bcl-2) in Warthin's tumor of parotid gland and also to clarify the role of these proteins in the behavior of that tumor.
  • METHODS: Twenty paraffin blocks of cases previously diagnosed as Warthin's tumor were collected for immunohistochemical staining with primary antibodies against mdm-2, p27Kip1 and bcl-2 using streptavidin-biotin immunoperoxidase staining system.
  • CONCLUSION: Mdm-2 played a tumor-suppressor role that might be implicated with the benign behavior of Warthin's tumor.

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  • (PMID = 19445705.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2693442
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27. Lardinois D, Weder W, Roudas M, von Schulthess GK, Tutic M, Moch H, Stahel RA, Steinert HC: Etiology of solitary extrapulmonary positron emission tomography and computed tomography findings in patients with lung cancer. J Clin Oncol; 2005 Oct 1;23(28):6846-53
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  • Histopathologic examinations of these 32 lesions revealed a second clinically unsuspected malignancy or a recurrence of a previous diagnosed carcinoma in six patients (19%) and a benign tumor or inflammatory lesion in 26 patients (81%).
  • Benign tumors and inflammatory lesions included eight colon adenomas, four Warthin's tumors, one granuloma of the lower jaw, one adenoma of the thyroid gland, one compensatory muscle activity due to vocal chord palsy, two occurrences of arthritis, three occurrences of reflux esophagitis, two occurrences of pancreatitis, two occurrences of diverticulitis, one hemorrhoidal inflammation, and one rib fracture.
  • CONCLUSION: Solitary extrapulmonary FDG accumulations in patients with newly diagnosed lung cancer should be analyzed critically for correct staging and optimal therapy, given that up to half of the lesions may represent unrelated malignancies or benign disease.

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  • (PMID = 16192576.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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28. Peter Klussmann J, Wittekindt C, Florian Preuss S, Al Attab A, Schroeder U, Guntinas-Lichius O: High risk for bilateral Warthin tumor in heavy smokers--review of 185 cases. Acta Otolaryngol; 2006 Dec;126(11):1213-7
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  • [Title] High risk for bilateral Warthin tumor in heavy smokers--review of 185 cases.
  • CONCLUSIONS: We identified smoking as a significant risk factor for multilocular Warthin tumor development.
  • OBJECTIVES: Warthin tumor is a common benign neoplasm of the parotid gland.
  • PATIENTS AND METHODS: A total of 185 consecutive patients treated for Warthin tumor were included.
  • Bilateral Warthin tumor was seen in 17% of patients.
  • Of these cases synchronous and metachronous bilateral tumors were observed in 61% and 39%, respectively.
  • The median time period for second contralateral tumor development was 7 years.
  • The risk for bilateral Warthin tumors correlated significantly with the amount of nicotine intake (p=0.003).
  • [MeSH-major] Adenolymphoma / etiology. Neoplasms, Multiple Primary / etiology. Parotid Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 17050316.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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29. Iwai H, Yamashita T: Local excision procedure for Warthin's tumor of the parotid gland. Otolaryngol Head Neck Surg; 2005 Apr;132(4):577-80
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  • [Title] Local excision procedure for Warthin's tumor of the parotid gland.
  • The aim of this work is to establish a local excision procedure (LEP) and indications of this procedure for Warthin's tumor.
  • Seventy-three patients (82 sides) with Warthin's tumor were studied.
  • For Warthin's tumor estimated to be below the I-S line (Group A), LEP was used, involving resection of the tumor after locating and dissecting the marginal mandibular and colli branches.
  • For tumors not meeting these criteria (Group B), partial superficial parotidectomy was performed.
  • Conversely, no significant difference in tumor size or incidence of postoperative facial paresis was identified between the 2 groups.
  • In conclusion, LEP is useful for Warthin's tumor below the I-S line.
  • This procedure seems applicable not only to Warthin's tumors, but also to other benign parotid tumors in the surgical field below the I-S line, such as pleomorphic adenoma and lymphoepithelial cyst.
  • [MeSH-major] Adenolymphoma / surgery. Microsurgery / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 15806048.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Maruya S, Kies MS, Williams M, Myers JN, Weber RS, Batsakis JG, El-Naggar AK: Differential expression of p63 isotypes (DeltaN and TA) in salivary gland neoplasms: biological and diagnostic implications. Hum Pathol; 2005 Jul;36(7):821-7
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  • TAp63 was highly expressed in most benign tumors and was either negative or weakly positive in most carcinomas.
  • JAG1 was expressed in most benign and malignant tumors and did not correlate with p63 isoforms expression.
  • We conclude that (1) p63 isoforms are differentially expressed in most benign and malignant tumors and may play distinct biological roles in certain salivary gland neoplasms;.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenolymphoma / metabolism. Adenoma, Pleomorphic / metabolism. Genes, Tumor Suppressor. Phosphoproteins / metabolism. Salivary Gland Neoplasms / metabolism. Trans-Activators / metabolism
  • [MeSH-minor] Calcium-Binding Proteins. DNA Primers / chemistry. DNA-Binding Proteins. Gene Expression Regulation, Neoplastic. Humans. Immunoenzyme Techniques. Intercellular Signaling Peptides and Proteins. Membrane Proteins / genetics. Membrane Proteins / metabolism. Protein Isoforms. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction. Salivary Glands / metabolism. Salivary Glands / pathology. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 16084953.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 134324-36-0 / Serrate proteins
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31. Ascani G, Pieramici T, Rubini C, Messi M, Balercia P: Synchronous bilateral Warthin's tumours of the parotid glands: a case report. Acta Otorhinolaryngol Ital; 2010 Dec;30(6):310-2
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  • [Title] Synchronous bilateral Warthin's tumours of the parotid glands: a case report.
  • Warthin's tumour is the most frequent monomorphic adenoma of the major salivary glands, representing about 2-15% of all parotid tumours.
  • Most of the multifocal Warthin's tumours are unilateral, whereas bilateral Warthin's tumours are far less common; bilateral Warthin's tumours are metachronous with few synchronous cases having been described in the literature.
  • The Authors present an interesting case of simultaneously occurring bilateral Warthin's tumours growing in the parotid glands.
  • [MeSH-major] Adenolymphoma / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 21808453.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3146325
  • [Keywords] NOTNLM ; Bilateral tumours / Multifocal tumours / Parotid gland / Salivary gland tumours / Warthin's tumour
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32. Chandrasekar T, Ramani P, Anuja N, Karthikeyan R, Abhilash PR, Narayan V, Giri VV: Unilocular cystic sebaceous lymphadenoma: a rare tumour. Ann R Coll Surg Engl; 2007 May;89(4):1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilocular cystic sebaceous lymphadenoma: a rare tumour.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology

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  • [Cites] BMC Med Inform Decis Mak. 2006;6:24 [16762051.001]
  • (PMID = 17535604.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1963539
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33. Ahn SH, Park SY: Sebaceous lymphadenocarcinoma of parotid gland. Eur Arch Otorhinolaryngol; 2006 Oct;263(10):940-2
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  • After postoperative adjuvant radiotherapy, the patient remains disease-free at 24 months postoperatively.
  • We here report a fifth case of this tumor and the youngest age at diagnosis among reported cases.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Adenolymphoma / diagnosis. Parotid Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis

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  • [Cites] Ann Diagn Pathol. 2003 Aug;7(4):236-9 [12913846.001]
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  • (PMID = 16786364.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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34. Aird DW, Puttasiddaiah P, Berry S, Spyridakou C, Kumar M: Spatial orientation of the facial nerve in relation to parotid tumours. J Laryngol Otol; 2006 May;120(5):371-4
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  • The relationship of the facial nerve to the tumour was graded into six types.
  • In 50 per cent of these cases, the tumour was in close association with the two major divisions of the facial nerve.
  • In the case of Warthin's tumours, 47 per cent were located in the tail, below the lower division of the facial nerve.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Facial Nerve / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Facial Paralysis / etiology. Facial Paralysis / pathology. Female. Follow-Up Studies. Hodgkin Disease / pathology. Hodgkin Disease / surgery. Humans. Male. Middle Aged. Prospective Studies

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  • (PMID = 16696874.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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35. Dalpa E, Gourvas V, Baritaki S, Miyakis S, Samaras V, Barbatis C, Sourvinos G, Spandidos DA: High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland. J Clin Virol; 2008 Jun;42(2):182-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High prevalence of Human Herpes Virus 8 (HHV-8) in patients with Warthin's tumors of the salivary gland.
  • BACKGROUND: Warthin's tumor is a common benign neoplasm of the salivary gland.
  • OBJECTIVES: To provide insights into the HHV-8 cell tropism, the presence of HHV-8 was investigated in a series of Warthin's tumors of the salivary gland and corresponding adjacent normal tissue.
  • STUDY DESIGN: Forty-three patients with Warthin's tumors (cystadenolymphoma) were tested for the presence of HHV-8 DNA, and corresponding adjacent normal tissue samples were obtained from 15 patients.
  • RESULTS: HHV-8 DNA was detected in 19 out of 43 (44%) salivary gland tumor samples.
  • Among the 15 cases with paired samples, 9 were HHV-8-positive for both samples, 4 were HHV-8-negative for both samples while in two cases HHV-8 was detected only in the tumor specimens.
  • CONCLUSIONS: HHV-8 is frequently detected in adenoid salivary neoplasms, suggesting a significant role of the virus in the etiopathogenesis of the disease.
  • Larger studies are required to investigate the role of HHV-8 in the development or progression of Warthin's tumors.
  • [MeSH-major] Adenolymphoma / virology. Herpesvirus 8, Human / isolation & purification. Salivary Gland Neoplasms / virology. Salivary Glands / virology

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  • (PMID = 18339579.001).
  • [ISSN] 1386-6532
  • [Journal-full-title] Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • [ISO-abbreviation] J. Clin. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Viral
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36. Cardoso SV, do Nascimento Souza KC, de Faria PR, Lima RA, Nascimento MF, Eisenberg AL, Dias FL, Loyola AM: Warthin's tumor at the Brazilian National Cancer Institute: additional evidence of homogeneous sex prevalence and association with other neoplasms. ORL J Otorhinolaryngol Relat Spec; 2008;70(6):339-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Warthin's tumor at the Brazilian National Cancer Institute: additional evidence of homogeneous sex prevalence and association with other neoplasms.
  • PURPOSE OF THE STUDY: To report the largest Brazilian series of Warthin's tumor (WT).
  • [MeSH-major] Adenolymphoma / epidemiology. Adenolymphoma / surgery. Lymph Nodes / pathology. Neoplasm Recurrence, Local / epidemiology. Parotid Neoplasms / epidemiology. Parotid Neoplasms / surgery

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18984968.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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37. Burgess AN, Serpell JW: Parotidectomy: preoperative investigations and outcomes in a single surgeon practice. ANZ J Surg; 2008 Sep;78(9):791-3
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  • RESULTS: The most common histopathology was benign lesions (89.6%), including pleomorphic adenoma (55.8%) and Warthin's tumour (11.7%).

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  • [CommentIn] ANZ J Surg. 2010 Mar;80(3):198-9 [20575936.001]
  • (PMID = 18844910.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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38. Colella G, Tozzi U, Pagliarulo V, Bove P: Warthin tumor: a potential source of diagnostic error. J Craniofac Surg; 2010 Nov;21(6):1978-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Warthin tumor: a potential source of diagnostic error.
  • PURPOSE: Warthin tumor, also known as papillary cystadenoma lymphomatosum, is a fairly common tumor.
  • It makes up 14% to 30% of parotid tumors.
  • There has been much interest in this tumor because of its typical and intriguing morphologic features: the association of benign-looking lymphoid and epithelial components and its frequent occurrence in the intraparotid or periparotid lymph nodes.
  • Moreover, multifocal and/or bilateral Warthin tumors have been reported, and malignant transformation of Warthin tumor and its association with other malignancies have been documented.
  • Warthin tumor can sometimes be confused with other pathologic lesions because of symptoms and signs that accompany the disease, so it could be treated as other pathologic lesions.
  • The first one had a differentiated squamous cell carcinoma, no lymph node metastasis, and a Warthin tumor of the left parotid gland.
  • RESULTS AND CONCLUSIONS: The aim of this study was to evaluate the clinical and histopathologic features of 3 cases where clinical presentation of a Warthin tumor lies in the possible errors in diagnosis and decision making and not least in the management of the patient.
  • [MeSH-major] Adenolymphoma / diagnosis. Diagnostic Errors. Parotid Neoplasms / diagnosis

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  • (PMID = 21119475.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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39. Breeze J, Andi A, Williams MD, Howlett DC: The use of fine needle core biopsy under ultrasound guidance in the diagnosis of a parotid mass. Br J Oral Maxillofac Surg; 2009 Jan;47(1):78-9
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  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Adenolymphoma / pathology. Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / ultrasonography. Humans. Prospective Studies. Sensitivity and Specificity

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  • [CommentIn] Br J Oral Maxillofac Surg. 2009 Sep;47(6):493-4 [19371985.001]
  • (PMID = 18539371.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Scotland
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40. Rawlinson NJ, Almarzooqi S, Nicol K: Sebaceous lymphadenoma of the parotid gland in a 13-year-old girl: a case report. Head Neck Pathol; 2010 Jun;4(2):144-7
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  • Sebaceous lymphadenoma is a benign rare tumor of the salivary gland.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology

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  • [Cites] Acta Otorhinolaryngol Ital. 2007 Jun;27(3):144-6 [17883193.001]
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  • (PMID = 20512641.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2878632
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41. Tanaka S, Tabuchi K, Oikawa K, Kohanawa R, Okubo H, Ikebe D, Noguchi M, Hara A: Synchronous unilateral parotid gland neoplasms of three different histological types. Auris Nasus Larynx; 2007 Jun;34(2):263-6
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  • A 67-year-old male with three synchronous tumors in the unilateral parotid gland is reported.
  • Postoperative histological examinations confirmed the presence of three synchronous primary tumors, specifically pleomorphic adenoma, Warthin's tumor and salivary duct carcinoma, in the right parotid gland.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Salivary Ducts / pathology

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  • (PMID = 16938417.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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42. Mihashi H, Kawahara A, Kage M, Kojiro M, Nakashima T, Umeno H, Sakamoto K, Chiziwa H: Comparison of preoperative fine-needle aspiration cytology diagnosis and histopathological diagnosis of salivary gland tumors. Kurume Med J; 2006;53(1-2):23-7
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  • [Title] Comparison of preoperative fine-needle aspiration cytology diagnosis and histopathological diagnosis of salivary gland tumors.
  • We investigated 115 patients with salivary gland epithelial tumors who had undergone preoperative fine needle aspiration cytology (FNAC) of salivary glands and had been diagnosed by postoperative histopathological examination.
  • We compared the findings of preoperative FNAC with their histopathological types in salivary gland tumors, and discuss the results and problems.
  • The rates of agreement in the diagnosis of pleomorphic adenoma, Warthin tumor, and basal cell adenoma were 96%, 92.9%, and 55.5%, respectively.
  • The rate of agreement of histopathological types in the malignant tumors was 30%.
  • We realized again not only that the diagnostic accuracy of preoperative FNAC for salivary gland tumors was high, but also that it was a safe, easy-to-perform, clinically very useful diagnostic procedure.
  • However, this study exposed several problems which are the inadequate sampling rate and the difficulty in diagnosing malignant tumors.

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  • (PMID = 17043392.001).
  • [ISSN] 0023-5679
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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43. Yuan WH, Hsu HC, Chou YH, Hsueh HC, Tseng TK, Tiu CM: Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands. Clin Imaging; 2009 Sep-Oct;33(5):348-53
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  • [Title] Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands.
  • Our aim was to assess the specific ultrasonic characteristics of pleomorphic adenoma and Warthin's tumor in major salivary glands.
  • METHODS: We retrospectively reviewed and analyzed the ultrasonographic (US) features of 19 pleomorphic adenomas in 16 patients and 29 Warthin's tumors in 20 patients.
  • The features included tumor size, echotexture, boundary, and shape on gray-scale US imaging and grading and distribution of tumor vascularity on color Doppler ultrasound (CDU).
  • Most of the tumors (87.5%) were >or=10 mm, and 93.8% were well defined.
  • Only two of 29 Warthin's tumors had the highest grade of vascularity (+++).
  • Predominantly central blood flow was present in 58.6% of Warthin's tumors and 42.1% of pleomorphic adenomas.
  • Lobulated margin (shape) was noted in 84.2% of pleomorphic adenomas and 51.7% of Warthin's tumors (P<.05).
  • Anechoic cystic components were present in 13 (44.8%) of 29 Warthin's tumors and in only one pleomorphic adenoma (1/19, 5.3%) (P<.01).
  • Internal anechoic cystic components were absent from pleomorphic adenomas but present in some Warthin's tumors.
  • The grading and distribution of blood flow signals on CDU provided only limited additional diagnostic information for distinguishing pleomorphic adenomas from Warthin's tumors.
  • Gray-scale ultrasonography is a useful method for evaluating and distinguishing pleomorphic adenomas from Warthin's tumors.
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Echocardiography, Doppler, Color / methods. Salivary Gland Neoplasms / ultrasonography

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  • (PMID = 19712813.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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44. Mahy P, Reychler H: [The pathology of salivary glands. Tumors of the salivary glands]. Rev Belge Med Dent (1984); 2006;61(3):141-53
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  • [Title] [The pathology of salivary glands. Tumors of the salivary glands].
  • The management of benign and malignant neoplasms of the salivary glands requires precise knowledge of tumor histogenesis and classification as well as surgical skills.
  • Pleomorphic adenoma and Whartin's tumor are the most frequent tumors in parotid glands while the probability for malignant tumors is higher in other glands, especially in sublingual and minor salivary glands.
  • Those malignant salivary glands tumors are rare and necessitate multidisciplinar staging and management in close collaboration with the pathologist and the radiation oncologist.
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Humans. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant. Salivary Glands, Minor / pathology. Sublingual Gland Neoplasms / pathology

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  • (PMID = 17408135.001).
  • [ISSN] 0775-0293
  • [Journal-full-title] Revue belge de médecine dentaire
  • [ISO-abbreviation] Rev Belge Med Dent (1984)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Belgium
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45. Bilewicz R, Burduk PK, Burduk D, Kaźmierczak W: [Multiple bilateral lymphatic adenomas of the parotid glands]. Otolaryngol Pol; 2006;60(2):139-42
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  • Whartin's tumour is mostly find in bilateral parotid gland tumours.
  • MATERIAL AND METHODS: The authors present an unusual case of 60 years old man with bilateral, multifocal Whartin's tumour of the parotid glands.
  • Minimal surgery procedures with tumour excision is the method of choice.
  • [MeSH-major] Adenolymphoma / surgery. Adenoma / surgery. Neoplasms, Multiple Primary / surgery. Parotid Neoplasms / surgery

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  • (PMID = 16903327.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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46. Fiorella R, Di Nicola V, Fiorella ML, Spinelli DA, Coppola F, Luperto P, Madami L: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):182-90
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  • Benign tumours account for 80% of case histories with a relationship 1:4 M/F, the most frequent being pleomorphic adenoma (57.3% of cases), followed by Warthin's tumour (32.4%), this rating not having been confirmed in case histories (8-10%) in the literature.
  • Enucleoresection was limited to approximately 15% of neoplasms, enucleation to <10% of cases with only 2% of pleomorph adenoma due to the well-known anatomo-pathological characteristics which may lead to relapse.
  • When no clinically evident lymph nodes were present (NO) considering the tumour histotype, two thirds of patients underwent surgery or radiotherapy, while in the remainder the wait-and-see attitude was prefered.

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  • [ErratumIn] Acta Otorhinolaryngol Ital. 2005 Oct;25(5):following 337
  • (PMID = 16450775.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639866
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47. Terada T: Hyperplastic intraparotid lymph nodes with incipient Warthin's tumor presenting as a parotid tumor. Pathol Res Pract; 2008;204(11):863-6
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  • [Title] Hyperplastic intraparotid lymph nodes with incipient Warthin's tumor presenting as a parotid tumor.
  • Reactive follicular hyperplasia of the intraparotid lymph nodes (IPLs) forming a parotid tumor has rarely been reported, and the pathogenesis of Warthin's tumor has not been determined.
  • A case of hyperplastic IPLs with incipient Warthin's tumors presenting as a parotid tumor is presented.
  • A 68-year-old Japanese patient presented with a tumor of the right parotid gland, and the tumor was resected.
  • Very small foci of Warthin's tumor were recognized in two of the IPLs.
  • Immunohistochemical studies showed that the oncocytes of the small Warthin's tumor and the ductular elements were positive for cytokeratin, but negative for carcinoembryonic antigen, vimentin, alpha-smooth muscle antigen, and S100 protein.
  • The present case suggests that reactive hyperplastic IPLs may form a parotid tumor, and that Warthin's tumor may develop in hyperplastic IPLs at the inception of its tumorigenesis.
  • [MeSH-major] Adenolymphoma / pathology. Lymph Nodes / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18572328.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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48. Kanazawa T, Ohta Y, Goutsu K, Takeoda K, Tsubaki K, Kodama K, Inoue R, Usubuchi H, Iino Y: [Significant factors affecting the operation time for benign parotid tumor]. Nihon Jibiinkoka Gakkai Kaiho; 2008 Jun;111(6):481-5
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  • [Title] [Significant factors affecting the operation time for benign parotid tumor].
  • Tumors of the parotid gland are fairly frequent among head and neck tumors.
  • Parotidectomy for benign tumors is necessary for diagnosis and therapy.
  • To measure the operation time and determine the factors affecting it, 71 cases, including 43 cases of pleomorphic adenomas and 28 cases Warthin's tumor, were retrospectively reviewed to the determine if the operation time depended on the age, sex, operated side, presence of complications, BMI, bleeding volume, tumor size, tumor location, exposure of branches of the facial nerve, and experience of the surgeon.
  • The results revealed that the bleeding volume, tumor size, tumor location and experience of the surgeon were significantly correlated with the operation time, whereas age, sex, operated side, presentation of complications and BMI showed no correlation with the operation time.
  • Taken together, to shorten the operation time, the inexperienced surgeon should start with smaller tumors and surgery in the superficial lobe in the initial training period, and supervision by well-experienced supervised surgeons is required until 30-40 are undertaken.

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  • (PMID = 18634454.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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49. Prades JM, Oletski A, Faye MB, Dumollard JM, Timoshenko AP, Veyret C, Peoc'h M, Martin C: [Parotid gland masses: diagnostic value of MR imaging with histopathologic correlations]. Morphologie; 2007 Mar;91(292):44-51
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  • [Transliterated title] Morphologie IRM des tuméfactions de la glande parotide. Corrélations histopathologiques.
  • RESULTS-CONCLUSIONS: In case of pleomorphic adenoma (N=30) MR imaging sensibility, specificity and accuracy were respectively 87.5, 80.5 and 83%.
  • In case of Warthin tumors (N=13) the same values were respectively 45.5, 93 and 85%.
  • In case of malignant tumors (N=13) theses values were respectively 71, 89 and 87%.
  • Our routine MR Imaging study appears excellent not only for assessing the type and extent of benign salivary gland tumors and the relationship to adjacent structures, but also for determining whether the tumor is benign or malignant.
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenolymphoma / pathology. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Adult. Aged. Aged, 80 and over. Carcinoma / diagnosis. Carcinoma / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Parotitis / diagnosis

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  • (PMID = 17652005.001).
  • [ISSN] 1286-0115
  • [Journal-full-title] Morphologie : bulletin de l'Association des anatomistes
  • [ISO-abbreviation] Morphologie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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50. Lohuis PJ, Tan ML, Bonte K, van den Brekel MW, Balm AJ, Vermeersch HB: Superficial parotidectomy via facelift incision. Ann Otol Rhinol Laryngol; 2009 Apr;118(4):276-80
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  • It can be offered as an alternative to a select group of patients who present with a small, mobile tumor in the tail of the parotid gland and an explicit request for an invisible postoperative scar.
  • [MeSH-minor] Adenolymphoma / surgery. Adenoma, Pleomorphic / surgery. Adult. Aged. Child. Child, Preschool. Cysts / surgery. Female. Humans. Male. Middle Aged. Rhytidoplasty

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  • (PMID = 19462848.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Lu YC, Fan WJ, Shen JX, Xiao P: [CT features of parotid tumors: an analysis of 133 cases]. Ai Zheng; 2007 Nov;26(11):1263-7
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  • [Title] [CT features of parotid tumors: an analysis of 133 cases].
  • BACKGROUND & OBJECTIVE: Most parotid tumors grow slowly.
  • This study was to analyze the CT features of parotid tumors.
  • METHODS: CT images of 133 patients with 157 lesions of parotid tumors, confirmed by histopathology, were reviewed.
  • RESULTS: Among the 157 lesions, 110 (70.1%) were benign tumors, 18 (11.5%) were borderline tumors, and 29 (18.5%) were malignant tumors; 80 (72.7%) benign lesions and 14 (77.8%) borderline lesions located in the superficial lobe, whereas 7 (24.1%) malignant lesions located in the deep lobe and 10 (34.5%) in both the superficial lobe and the deep lobe; 99 (90.0%) benign lesions had sharp margins, 8 (44.4%) borderline lesions had sharp margins and 10 (55.6%) had partly unsharp margins, 10 (34.5%) malignant lesions had partly unsharp margins and 11 (37.9%) had unsharp margins.
  • Eleven lesions, including 2 borderline tumors and 9 malignant tumors, involved the adjacent subcutaneous fat.
  • No benign tumor involved adjacent structures.
  • CONCLUSION: On CT images, a parotid tumor located in the superficial lobe, with a round or oval contour and sharp margin, is more likely to be a benign tumor; otherwise, it might be a malignant tumor.
  • [MeSH-major] Adenolymphoma / radiography. Carcinoma, Mucoepidermoid / radiography. Parotid Neoplasms / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / radiography. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Acinar Cell / pathology. Carcinoma, Acinar Cell / radiography. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiography. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Parotid Gland / pathology. Parotid Gland / radiography. Retrospective Studies. Young Adult

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  • (PMID = 17991330.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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52. Wagner M, Klussmann JP, Dirsch O, Rose VA, Guntinas-Lichius O, Theegarten D, Sudhoff H, Linder R: Low prevalence of transfusion transmitted virus (TTV)-like DNA sequences in cystadenolymphoma and pleomorphic adenoma of the salivary glands. Eur Arch Otorhinolaryngol; 2006 Aug;263(8):759-63
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  • [Title] Low prevalence of transfusion transmitted virus (TTV)-like DNA sequences in cystadenolymphoma and pleomorphic adenoma of the salivary glands.
  • The present study was conducted to determine whether TTV-like DNA sequence elements play a role in the pathogenesis of cystadenolymphoma or pleomorphic adenoma and if the parotid or the submandibular gland is a major source of TTV persistence.
  • TTV appears to be only a bystander in cystadenolymphoma, pleomorphic adenoma, and other salivary gland affections.
  • [MeSH-major] Adenolymphoma / virology. Adenoma, Pleomorphic / virology. DNA, Viral / analysis. Salivary Gland Neoplasms / virology. Torque teno virus / genetics

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  • [ErratumIn] Eur Arch Otorhinolaryngol. 2006 Nov;263(11):1060
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  • (PMID = 16703387.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Viral
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53. Becelli R, Morello R, Renzi G, Dominici C: Warthin's tumor of the hard palate. J Craniofac Surg; 2007 Sep;18(5):1182-4
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  • [Title] Warthin's tumor of the hard palate.
  • Warthin's Tumor (WT) or papillary cystadenoma lymphomatosum is typically located in parotid gland.
  • [MeSH-major] Adenolymphoma / pathology. Palatal Neoplasms / pathology. Palate, Hard / pathology

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  • (PMID = 17912110.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Nakahara T, Suzuki T, Hashimoto J, Shigematsu N, Tomita T, Ogawa K, Kubo A: Role of salivary gland scintigraphy with Tc-99m pertechnetate in determining treatment of solitary parotid gland tumors: a retrospective study. Clin Nucl Med; 2007 May;32(5):363-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of salivary gland scintigraphy with Tc-99m pertechnetate in determining treatment of solitary parotid gland tumors: a retrospective study.
  • PURPOSE OF THE REPORT: Although salivary gland scintigraphy has been useful for the diagnosis of Warthin's tumor (WT), there are no reports concerning the clinical impact of this scintigraphy.
  • MATERIALS AND METHODS: We retrospectively investigated 127 patients with solitary parotid tumors who had undergone salivary gland scintigraphy.

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  • (PMID = 17452863.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] A0730CX801 / Sodium Pertechnetate Tc 99m
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55. Chakrabarti S, Bera M, Bhattacharya PK, Chakrabarty D, Manna AK, Pathak S, Maiti K: Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry. J Indian Med Assoc; 2010 Dec;108(12):833-6
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  • Pre-operative core needle biopsy is hazardous and may damage facial nerve, lead to fistula formation or associated with tumour seeding.
  • Among these 3 cases, 2 were adenoid cystic carcinoma which was cytologically diagnosed as benign neoplasm (monomorphic adenoma).
  • One case of Warthin's tumour was cytologically diagnosed as pleomorphic adenoma.

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  • (PMID = 21661459.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] India
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56. Pescarmona E, Perez M, Faraggiana T, Granati L, Baroni CD: Nodal peripheral T-cell lymphoma associated with Warthin's tumour. Histopathology; 2005 Aug;47(2):221-2
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  • [Title] Nodal peripheral T-cell lymphoma associated with Warthin's tumour.
  • [MeSH-major] Adenolymphoma / pathology. Lymphoma, T-Cell, Peripheral / pathology

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  • (PMID = 16045788.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD20; 0 / Antigens, CD3; 0 / Antigens, CD30; 0 / Antigens, CD43; 0 / Antigens, CD79; 0 / CD79A protein, human; 0 / Receptors, Antigen, B-Cell; 0 / Sialoglycoproteins; 0 / UN1 sialoglycoprotein, human
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57. Kawata R, Yoshimura K, Lee K, Araki M, Takenaka H, Tsuji M: Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases--basal cell adenoma versus pleomorphic adenoma and Warthin's tumor. Eur Arch Otorhinolaryngol; 2010 May;267(5):779-83
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  • [Title] Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases--basal cell adenoma versus pleomorphic adenoma and Warthin's tumor.
  • The aim of this study is to investigate the clinical and pathological characteristics of basal cell adenoma (BCA) and to compare the diagnosis/treatment of BCA with those of Warthin's tumor (WT) and pleomorphic adenoma (PA).
  • Among 192 patients with benign tumors of the parotid gland who underwent surgery, 9 had BCA.
  • All of these tumors showed a benign pattern on computed tomography and magnetic resonance imaging.
  • Considering the gender difference, tumor site, and age, it is necessary to differentiate BCA from PA rather than from WT.
  • BCA is the third most common of the benign parotid tumors, following WT and PA, although its incidence is low.
  • When PA and WT are ruled out by FNAB after a tentative diagnosis of benign tumor has been based on imaging findings, BCA should be considered.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma / pathology. Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19908055.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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58. Hisatomi M, Asaumi J, Yanagi Y, Unetsubo T, Maki Y, Murakami J, Matsuzaki H, Honda Y, Konouchi H: Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. Oral Oncol; 2007 Oct;43(9):940-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors.
  • To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in salivary gland tumors, thirty-five patients (47 lesions) who underwent MR examinations and were histopathologically diagnosed with salivary gland tumors in Okayama University Hospital, between April 1998 and March 2005, were entered in the present study.
  • (a) The salivary gland tumors were categorized into three CI curve types according to Tmax and WR300; Pleomorphic adenoma; Tmax > 210 s and WR300 < 10%, Warthin tumor; Tmax < 60 s and WR300 > 40%, and malignant tumor; 60s < Tmax < 210 s and 10% < WR300 < 30%;.
  • (b) On the basis of the relationship between Tmax and CImax or WR, all pleomorphic adenomas were successfully differentiated from Warthin tumor lesions.
  • Of the 20 pleomorphic adenomas, 18 (90.0%) were successfully differentiated from malignant tumors.
  • All Warthin tumor lesions were successfully differentiated from pleomorphic adenomas and malignant tumors.
  • Of 12 the malignant tumors, 11 (91.7%) were successfully differentiated from pleomorphic adenomas.
  • All malignant tumors were successfully differentiated from Warthin tumors.
  • Thus, DCE-MRI parameters are useful in diagnosing salivary gland tumors on the basis of the combined assessment of Tmax and CImax or WR.
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenoma, Pleomorphic / diagnosis. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Parotid Neoplasms / diagnosis. Sensitivity and Specificity

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  • (PMID = 17257881.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; K2I13DR72L / Gadolinium DTPA
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59. Gallipoli A, Manganella G, De Lutiodi di Castelguidone E, Mastro A, Ionna F, Pezzullo L, Vallone P: Ultrasound contrast media in the study of salivary gland tumors. Anticancer Res; 2005 May-Jun;25(3c):2477-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrasound contrast media in the study of salivary gland tumors.
  • BACKGROUND: The aims of the present study were: to assess standard ultrasound and color-Doppler patterns for the study and characterization of salivary gland tumors; to define the improvement in the color-Doppler ultrasound image after injection of a signal amplifier (Levovist); to compare morphological and vascular aspects of the neoplasm with data obtained during postoperative histopathological analysis.
  • [MeSH-minor] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Adult. Aged. Carcinoma / ultrasonography. Contrast Media. Female. Humans. Lipoma / ultrasonography. Male. Middle Aged


60. Saxena A, Memauri B, Hasegawa W: Initial diagnosis of small lymphocytic lymphoma in parotidectomy for Warthin tumour, a rare collision tumour. J Clin Pathol; 2005 Mar;58(3):331-3
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  • [Title] Initial diagnosis of small lymphocytic lymphoma in parotidectomy for Warthin tumour, a rare collision tumour.
  • Warthin tumours (WT) and malignant lymphomas are only rarely associated, and most are examples of involvement of the lymphoid stroma of WT by a disseminated lymphoma.
  • The patient had stage IV A disease and is currently in chemotherapy induced complete remission.
  • [MeSH-major] Adenolymphoma / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 15735173.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770608
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61. Ozcan C, Apa DD, Vayisoglu Y, Görür K: Unilateral parotid gland involvement with synchronous multiple Basal cell adenomas. J Craniofac Surg; 2007 Nov;18(6):1470-3
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  • Basal cell adenoma (BCA) is a rare benign epithelial tumor of the salivary gland.
  • Salivary gland tumors are observed as single tumors in one salivary gland.
  • Double or multiple tumors of the salivary gland tumors are unusual and metachronous or bilateral salivary gland tumors are more observed than synchronous or unilateral tumors.
  • The most commonly seen multiple tumor unilaterally or bilaterally is the Warthin's tumor.
  • More extensive excision of the parotid gland tumor, careful macroscopic perioperative examination of the surgical specimen, and histologic evaluation of all surgical specimens might be necessary for reducing revision operations and surgical complications.
  • [MeSH-major] Adenoma / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma / diagnosis. Aged. Diagnosis, Differential. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 17993904.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Oda E, Nakamura Y, Yamamoto M, Kojiro M: Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues. Kurume Med J; 2005;52(4):117-25
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  • In neoplastic tissues, tubulin beta II immunoreactivity was detected in various nervous system neoplasms and other neoplasms such as pancreatic solid cystic carcinoma, pleomorphic adenoma, Warthin's tumor, nephroblastoma, basal cell carcinoma and malignant mesothelioma.
  • We conclude that our monoclonal antibody, KNY379, may be useful as a marker of nervous system neoplasm, pancreatic solid cystic carcinoma, pleomorphic adenoma, Warthin's tumor, nephroblastoma, basal cell carcinoma and malignant mesothelioma.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Blotting, Western. Child, Preschool. Humans. Immunohistochemistry. Infant. Mesothelioma / chemistry. Middle Aged. Protein Isoforms

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  • (PMID = 16639982.001).
  • [ISSN] 0023-5679
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protein Isoforms; 0 / Tubulin
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63. Steele NP, Sampogna D, Sessions RB: Kaposi's sarcoma of an intraparotid lymph node leading to a diagnosis of HIV. Laryngoscope; 2005 May;115(5):861-3
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  • The patient underwent a right superficial parotidectomy for a suspected diagnosis of Warthin's tumor, given the bilaterality of the lesions.
  • [MeSH-minor] Adenolymphoma / diagnosis. Biopsy, Needle. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged


64. Ochicha O, Malami S, Mohammed A, Atanda A: A histopathologic study of salivary gland tumors in Kano, northern Nigeria. Indian J Pathol Microbiol; 2009 Oct-Dec;52(4):473-6
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  • [Title] A histopathologic study of salivary gland tumors in Kano, northern Nigeria.
  • Significant differences in the global distribution of salivary gland tumors have been reported, but no formal study has been carried out here in Kano, the largest city in northern Nigeria.
  • Seventy-eight salivary gland tumors were diagnosed during the eight-year study period accounting for 0.4% of all neoplasms.
  • Benign tumors were more prevalent, comprising 56.4%, while malignancies were 43.6%.
  • Pleomorphic adenoma and mucoepidermoid carcinoma were the commonest histological types constituting 48.7% and 23.1% respectively, while the most frequent sites were parotid, submandibular and minor salivary glands accounting for 49%, 26% and 24% respectively.
  • As in most studies of black populations there were no adenolymphomas.
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / pathology. Adolescent. Adult. Age Factors. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Mucoepidermoid / pathology. Female. Histocytochemistry. Humans. Male. Middle Aged. Nigeria / epidemiology. Prevalence. Salivary Glands / pathology. Young Adult

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  • (PMID = 19805949.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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65. Panayiotides IG, Foukas PG, Meristoudis C, Zourla AP, Peros G, Karakitsos P: Simultaneous occurrence of Warthin-like papillary carcinoma and lymphoma of the mucosa associated lymphoid tissue in Hashimoto thyroiditis. J Clin Pathol; 2010 Jul;63(7):662-3
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  • [Title] Simultaneous occurrence of Warthin-like papillary carcinoma and lymphoma of the mucosa associated lymphoid tissue in Hashimoto thyroiditis.
  • [MeSH-major] Adenolymphoma / pathology. Hashimoto Disease / complications. Lymphoma, B-Cell, Marginal Zone / pathology. Neoplasms, Multiple Primary / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 20591920.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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66. Giefing M, Wierzbicka M, Rydzanicz M, Cegla R, Kujawski M, Szyfter K: Chromosomal gains and losses indicate oncogene and tumor suppressor gene candidates in salivary gland tumors. Neoplasma; 2008;55(1):55-60
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  • [Title] Chromosomal gains and losses indicate oncogene and tumor suppressor gene candidates in salivary gland tumors.
  • The incidence of salivary gland tumor in Poland is growing in the last two decades.
  • Simultaneously a progress in understanding the genetic mechanisms of formation of this tumor was achieved by detecting several genes like PLAG1 involved in its pathogenesis.
  • In this study we perform a whole genome, CGH analysis with the aim to identify recurrent, chromosomal copy number changes possibly indicating novel tumor suppressor gene or oncogene loci.
  • 29 salivary tumor samples: Cystadenolymphoma-warthin (15) and adenoma polymorphum (14) located in the parotid (27) and submandibular gland (2) were collected and CGH was performed.
  • Altogether, salivary gland tumors presented a different aberration pattern than these reported for head and neck squamous cell carcinoma (HNSCC) but no significant differences were observed between Warthin and adenoma polymorphum tumors.
  • Moreover, several potential tumor suppressor genes and oncogenes were identified in the smallest, common altered regions.
  • We show a frequent deletion of the harakiri gene (12q24.2) in 12/29 tumors and TP53 gene (17p13.1) in 11/29 tumors as potential tumor suppressors in salivary gland cancers.
  • The observed alterations may indicate important genetic events in the formation of salivary gland tumors.
  • Especially the amplification in 13q may be a mechanism contributing to the expression of survivin and tumor progression.
  • [MeSH-major] Adenolymphoma / genetics. Adenoma, Pleomorphic / genetics. Chromosome Aberrations. Genes, Tumor Suppressor. Oncogenes. Salivary Gland Neoplasms / genetics

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  • (PMID = 18190242.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Slovakia
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67. Bozzato A, Zenk J, Greess H, Hornung J, Gottwald F, Rabe C, Iro H: Potential of ultrasound diagnosis for parotid tumors: analysis of qualitative and quantitative parameters. Otolaryngol Head Neck Surg; 2007 Oct;137(4):642-6
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  • [Title] Potential of ultrasound diagnosis for parotid tumors: analysis of qualitative and quantitative parameters.
  • OBJECTIVE: Histology of parotid tumors determines the extent of surgery.
  • SUBJECTS AND METHODS: A total of 64 male and 61 female patients with a mean age of 54 years were included, with 13 malignant tumors.
  • RESULTS: A total of 92.8% of tumors were classified correctly as malignant or benign.
  • The sensitivity, specificity, positive- and negative-predictive values were 66.7%, 86.3%, 60.6%, and 89.1% for differentiating Warthin tumors, but only 46.2%, 98.2%, 75%, and 94% for malignant lesions.
  • Contrast parameters yielded significant parameters for benign tumors, not for malignant entities.
  • CONCLUSION: Although contrast medium analysis provided statistical criteria, these, however, do not possess the ability to improve the diagnostic prediction of tumor histology.
  • Neither the morphologic classification nor contrast medium analysis was able to identify a malignant lesion sufficiently.
  • [MeSH-minor] Adenolymphoma / pathology. Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / ultrasonography. Contrast Media. Cross-Sectional Studies. Female. Humans. Image Enhancement / methods. Image Processing, Computer-Assisted / methods. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity. Single-Blind Method

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  • (PMID = 17903584.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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68. Guntinas-Lichius O, Klussmann JP, Wittekindt C, Stennert E: Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. Laryngoscope; 2006 Apr;116(4):534-40
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  • [Title] Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations.
  • OBJECTIVE/HYPOTHESIS: The objective of this study was to analyze the perioperative and long-term complications after standardized lateral and total parotidectomy for benign parotid tumors and chronic parotitis with special regard on the training skill of the surgeons at a university teaching center.
  • First recurrence for pleomorphic adenoma was observed in 2% and for Warthin's tumor in 3%.
  • CONCLUSIONS: Standardized education in lateral and total parotidectomy for treatment of benign parotid disease under precise microscopic control is safe, demonstrates good results, and has low perioperative and long-term morbidity.

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  • (PMID = 16585855.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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69. Kwon YD, Biesterfeld S, Hansen T, Schwerdtfeger A, Kunkel M: Lymphadenomatous carcinoma of the sublingual gland: report of a first case in an unusual localization. Head Neck; 2008 Oct;30(10):1394-8
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  • BACKGROUND: Lymphadenomatous carcinoma of the salivary gland is a very rare tumor, which hitherto occurred exclusively in the parotid gland.
  • [MeSH-major] Adenolymphoma / pathology. Carcinoma, Adenoid Cystic / pathology. Sublingual Gland Neoplasms / pathology

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  • [Copyright] Copyright (c) 2008 Wiley Periodicals, Inc. Head Neck 2008.
  • (PMID = 18327777.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Seethala RR, LiVolsi VA, Baloch ZW: Relative accuracy of fine-needle aspiration and frozen section in the diagnosis of lesions of the parotid gland. Head Neck; 2005 Mar;27(3):217-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenolymphoma / pathology. Biopsy, Needle. Carcinoma, Mucoepidermoid / pathology. Frozen Sections. Humans. Retrospective Studies. Sensitivity and Specificity

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  • [Copyright] 2005 Wiley Periodicals, Inc.
  • (PMID = 15672359.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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71. Shigeishi H, Yoneda S, Taki M, Nobumori T, Ohta K, Higashikawa K, Yasui W, Kamata N: Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors. Oncol Rep; 2006 Apr;15(4):933-8
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  • [Title] Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors.
  • We examined the expression of Bub1 mRNA and protein in 21 human salivary gland tumors (7 pleomorphic adenomas, 2 warthin tumors, 5 mucoepidermoid carcinomas, 3 adenoid cystic carcinomas and 4 acinic cell carcinomas) and 3 normal submandibular glands using real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) or western blotting.
  • The mean expression levels of Bub1 mRNA and protein were higher in malignant tumors (0.12+/-0.028/1.75+/-0.53) than normal submandibular glands (0.042+/-0.014/0.19+/-0.044) and benign tumors (0.058+/-0.01/0.97+/-0.44).
  • We found a significant association between the level of Bub1 mRNA/protein expression and clinical stage in malignant tumors (Mann-Whitney U test, p=0.019/p=0.016).
  • A significant correlation was found between Bub1 mRNA/protein expression and the Ki-67 labeling index in salivary gland tumors (Spearman's correlation coefficient by rank test, p=0.026/p=0.002).
  • [MeSH-minor] Adenolymphoma / genetics. Adenolymphoma / metabolism. Adenolymphoma / pathology. Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Blotting, Western. Carcinoma, Acinar Cell / genetics. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Neoplasm Staging. Proliferating Cell Nuclear Antigen / analysis. Protein-Serine-Threonine Kinases. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16525682.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / RNA, Messenger; EC 2.7.- / Protein Kinases; EC 2.7.11.1 / BUB1 protein, human; EC 2.7.11.1 / Bub1 spindle checkpoint protein; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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72. Hu J, Ye W, Zheng J, Zhu H, Zhang Z: The feasibility and significance of preservation of the lobular branch of the great auricular nerve in parotidectomy. Int J Oral Maxillofac Surg; 2010 Jul;39(7):684-9
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  • Ninety-three patients with benign tumour undergoing parotidectomy were separated randomly into three groups.
  • [MeSH-minor] Adenolymphoma / surgery. Adenoma, Pleomorphic / surgery. Adult. Aged. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neck Muscles / innervation. Pain / physiopathology. Pain Threshold / physiology. Recovery of Function / physiology. Sensory Thresholds / physiology. Time Factors. Touch / physiology. Young Adult

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  • [Copyright] Copyright 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20413273.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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73. Wierzgoń J, Szymczyk C, Maciejewski A, Półtorak S: [Partial parotidectomy--alternative method in surgical management of parotid gland Warthin tumours]. Otolaryngol Pol; 2007;61(2):142-6
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  • [Title] [Partial parotidectomy--alternative method in surgical management of parotid gland Warthin tumours].
  • 82 patients with adenolymphoma of parotid gland treated with surgery in Department of Oncological Surgery Cancer Center, Gliwice in the period of 1986-2004 were retrospectively analyzed.
  • They were about 22% of all patients with parotid gland tumors operated in that period.
  • Local recurrence occurred in less then 5%, only in cases with multiple tumor in histopathological examinations.
  • Partial resection of the parotid gland could be useful method of surgical treatment of adenolymphoma selected cases.
  • In analyzed group the local recurrence was always combined with multi lesional growth of the tumor.
  • [MeSH-major] Adenolymphoma / surgery. Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Facial Nerve / physiopathology. Facial Paralysis / etiology. Facial Paralysis / prevention & control. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Postoperative Complications / mortality. Quality of Life. Retrospective Studies. Surgical Procedures, Operative / methods. Survival Rate. Treatment Outcome

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  • (PMID = 17668799.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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74. Jung SM, Hao SP: Warthin's tumor with multiple granulomas: a clinicopathologic study of six cases. Diagn Cytopathol; 2006 Aug;34(8):564-7
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  • [Title] Warthin's tumor with multiple granulomas: a clinicopathologic study of six cases.
  • Granulomatous inflammation occurring in Warthin's tumor is a rare phenomenon.
  • We studied cases of Warthin's tumor with granulomatous inflammation to analyze the possible relationship with prior FNA.
  • Granulomatous inflammation was noted in 6 cases (1.6%) of 382 cases of Warthin's tumor in a medical center.
  • All 6 cases showed typical features of Warthin's tumor accompanied by multiple granulomas.
  • There were 2 cases with history of preoperative FNA; both already had granulomas in Warthin's tumor in cytologic specimens taken by aspiration.
  • The pathogenesis of granulomatous inflammation in Warthin's tumor remains speculative.
  • [MeSH-major] Adenolymphoma / etiology. Adenolymphoma / pathology. Granuloma / etiology. Parotid Neoplasms / etiology

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16850483.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Zhang S, Bao R, Bagby J, Abreo F: Fine needle aspiration of salivary glands: 5-year experience from a single academic center. Acta Cytol; 2009 Jul-Aug;53(4):375-82
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  • The only false positive was a pleomorphic adenoma misdiagnosed as adenoid cystic carcinoma.
  • Five benign neoplasms were interpreted as reactive processes, including 2 Warthin's tumors, 2 sebaceous lymphoadenomas and 1 pleomorphic adenoma.

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  • (PMID = 19697720.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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76. Zhang S, Bao R, Abreo F: Papillary oncocytic cystadenoma of the parotid glands: a report of 2 cases with varied cytologic features. Acta Cytol; 2009 Jul-Aug;53(4):445-8
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  • [Title] Papillary oncocytic cystadenoma of the parotid glands: a report of 2 cases with varied cytologic features.
  • BACKGROUND: Papillary cystadenoma is a rare salivary gland neoplasm, and oncocytic change can be focal or marked.
  • Papillary oncocytic cystadenoma has been reported mainly in the minor salivary glands and occasionally in the parotid glands.
  • Oncocytic neoplasm was diagnosed during intraoperative consultation, and final surgical histology showed a unilocular, cystic, oncocytic neoplasm with variable papillary projections.
  • FNA showed less cellular smears with extensive necrotic debris and a few large sheets of epithelial cells with vague papillary architecture.
  • Oncocytic neoplasm was diagnosed during intraoperative consultation, and final surgical histology showed a unilocular cystic lesion with multiple papillary fronds lined with oncocytic cells and focal metaplastic squamous cells.
  • CONCLUSION: Papillary cystadenoma is rare in the parotid glands, and cytologic features may vary.
  • Warthin's tumor, oncocytoma, intraductal papilloma and acinic cell carcinoma may arise in the differential diagnosis.
  • [MeSH-major] Cystadenoma, Papillary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19697734.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Freedman LS, Oberman B, Sadetzki S: Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin's tumor risk. Am J Epidemiol; 2009 Nov 1;170(9):1178-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin's tumor risk.
  • The authors aimed to elucidate the relation of the time-dependent smoking history parameters--age at smoking initiation and smoking intensity, duration, and latency--to the risk of Warthin's tumor, a benign tumor of the salivary gland for which cigarette smoking is a strong risk factor.
  • They studied 117 cases of Warthin's tumor and 336 matched controls included in an Israeli nationwide case-control study of parotid gland tumors conducted from 2002 to 2003 by using the Cox regression model with time-dependent covariates, with age as the time axis.
  • The latter finding implies that the effect of time since cessation dominates the effect of age at initiation, with risk decreasing sharply after smoking cessation.
  • The relation of smoking variables to Warthin's tumor agrees with the patterns reported for lung cancer.
  • [MeSH-major] Adenolymphoma / etiology. Salivary Gland Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 19755633.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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78. Brunese L, Ciccarelli R, Fucili S, Romeo A, Napolitano G, D'Auria V, Collina A, Califano L, Cappabianca S, Sodano A: Pleomorphic adenoma of parotid gland: delayed enhancement on computed tomography. Dentomaxillofac Radiol; 2008 Dec;37(8):464-9
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  • [Title] Pleomorphic adenoma of parotid gland: delayed enhancement on computed tomography.
  • On the basis of a statistical comparison, the third phase proved to be the most effective in the differential diagnosis between pleomorphic adenoma and non-pleomorphic adenomas, both for the assessment of the degree of the enhancement (in this phase, strong enhancement showed a sensitivity of 61.11%, specificity of 100%, positive predictive value (PPV) of 100% and negative predictive value (NPV) of 53.33%) and, above all, for the homogeneity of the enhancement (in this phase, indeed, uniform enhancement showed sensitivity, specificity, PPV and NPV of 100%).
  • [MeSH-major] Adenoma, Pleomorphic / radiography. Parotid Neoplasms / radiography. Radiographic Image Enhancement / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenolymphoma / radiography. Adult. Aged. Aged, 80 and over. Carcinoma, Acinar Cell / radiography. Carcinoma, Mucoepidermoid / radiography. Carcinoma, Squamous Cell / radiography. Contrast Media. Diagnosis, Differential. Female. Humans. Image Processing, Computer-Assisted / methods. Male. Middle Aged. Prospective Studies. Time Factors

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  • (PMID = 19033432.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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79. Brennan PA, Davies B, Poller D, Mead Z, Bayne D, Puxeddu R, Oeppen RS: Fine needle aspiration cytology (FNAC) of salivary gland tumours: repeat aspiration provides further information in cases with an unclear initial cytological diagnosis. Br J Oral Maxillofac Surg; 2010 Jan;48(1):26-9
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  • METHODS: A retrospective study of 135 patients who had FNAC followed by definitive excision for a suspected salivary gland tumour.
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Cytodiagnosis. Diagnosis, Differential. Humans. Lymphoma / pathology. Parotid Neoplasms / pathology. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Submandibular Gland Neoplasms / pathology. Ultrasonography, Interventional

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  • [Copyright] Copyright 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19233526.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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80. Dăguci L, Simionescu C, Dăguci C, Bătăiosu M, Dragomir LP: Clinical and Morphological Aspects of Warthin's Tumor. Curr Health Sci J; 2009 Apr;35(2):115-8
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  • [Title] Clinical and Morphological Aspects of Warthin's Tumor.
  • The study includes 16 cases of Warthin's tumor in a period of 4 years (2004-2008).
  • The tumors were diagnosed at patients of VII decade, most of them smoker.
  • The studies of Warthin's tumor macroscopic morphological parameters allow us to establish the localization exclusive at parotid glands like solitary tumor and the tumoral volume oscillate mostly between 2-4 cm in diameter.
  • Histopathologically we notice the prevalence of typical tumor forms, with balanced raport epithelium / stroma.

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  • (PMID = 24778816.001).
  • [ISSN] 2067-0656
  • [Journal-full-title] Current health sciences journal
  • [ISO-abbreviation] Curr Health Sci J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Other-IDs] NLM/ PMC3945243
  • [Keywords] NOTNLM ; Warthin’s tumor / salivary gland / stroma / tumoral pattern
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81. Párraga-Linares L, Aguirre-Urízar JM, Berini-Aytés L, Gay-Escoda C: Papillary cystoadenoma lymphomatosum (Warthin-like) of minor salivary glands. Med Oral Patol Oral Cir Bucal; 2009 Nov;14(11):e597-600
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  • [Title] Papillary cystoadenoma lymphomatosum (Warthin-like) of minor salivary glands.
  • Papillary cystadenoma lymphomatosum is a benign salivary gland tumor most frequently located in the parotid gland (Warthin's tumor).
  • Clinically, it manifests as a slow growing tumor, fluctuant on palpation due to its cystic morphology.
  • The treatment of choice is complete excision with wide tumor-free margins.
  • We present a 73-year-old female patient with an asymptomatic tumor of 8 years evolution in the right posterior area of the hard palate.
  • We performed surgical excision and a biopsy, which was reported as papillary cystadenoma lymphomatosum.
  • The lesion was re-operated, performing the excision with CO2 laser and including the periosteum to ensure complete resection of the tumor.
  • [MeSH-major] Adenolymphoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 19680204.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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82. Kim HH, Myssiorek D, Heller KS, Zahurullah F, Bhuiya T: Warthin-like tumor of the thyroid gland: an uncommon variant of papillary thyroid cancer. Ear Nose Throat J; 2006 Jan;85(1):56-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Warthin-like tumor of the thyroid gland: an uncommon variant of papillary thyroid cancer.
  • Several variants of papillary thyroid cancer have been described, including, most recently, Warthin-like tumor of the thyroid gland.
  • Among these cases, we identified 5 patients who had had a Warthin-like tumor of the thyroid.
  • Pathologic specimens were reviewed for tumor size, capsular invasion, and vascular invasion.
  • Tumor size ranged from 0.9 to 2.0 cm.
  • [MeSH-major] Adenolymphoma / pathology. Carcinoma, Papillary / pathology. Thyroid Neoplasms / pathology


83. Galed-Placed I: Granulomas with toxoplasmic features in a Warthin's tumor of the parotid gland. Acta Cytol; 2009 Jul-Aug;53(4):475-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granulomas with toxoplasmic features in a Warthin's tumor of the parotid gland.
  • [MeSH-major] Adenolymphoma / pathology. Granuloma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19697741.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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84. Bell D, Luna MA: Warthin adenocarcinoma: analysis of 2 cases of a distinct salivary neoplasm. Ann Diagn Pathol; 2009 Jun;13(3):201-7
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  • [Title] Warthin adenocarcinoma: analysis of 2 cases of a distinct salivary neoplasm.
  • Carcinomas arising in or from the epithelial component of preexisting parotid Warthin tumors (WTs) are rare; the other histologic types of carcinoma found to arise from WTs are adenocarcinoma not otherwise specified, undifferentiated, mucoepidermoid, squamous cell, and oncocytic.
  • We have designated this neoplasm "Warthin adenocarcinoma" (WA).
  • We identified 2 cases of WA; both patients were women, 44 and 60 years of age, with 4.0- and 4.5-cm tumors in the left parotid gland.
  • Histologically, the tumors were composed of bilayered duct-like structures: The inner layer was formed by a single row of columnar oxyphilic cells expressing CK7, CK14, CK18, and AMA.
  • Patients were free of disease 1 and 3 years after treatment.
  • Warthin adenocarcinoma is a unique salivary gland carcinoma representing the malignant epithelial counterpart of WT.
  • The identification of additional cases would help to better elucidate the line of differentiation of the tumor and further define its natural history.
  • [MeSH-major] Adenocarcinoma / pathology. Adenolymphoma / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 19433301.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Ethunandan M, Pratt CA, Morrison A, Anand R, Macpherson DW, Wilson AW: Multiple synchronous and metachronous neoplasms of the parotid gland: the Chichester experience. Br J Oral Maxillofac Surg; 2006 Oct;44(5):397-401
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  • Multiple tumours were likely to be of the same histology (n=24, 80%) and Warthin's was by far the most common multiple tumour.
  • [MeSH-major] Adenolymphoma / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Second Primary / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma, Oxyphilic / pathology. Adenoma, Pleomorphic / pathology. Adult. Aged. Aged, 80 and over. England. Female. Humans. Lipoma / pathology. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16207507.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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86. Roy S, Dhingra KK, Gupta P, Khurana N, Gupta B, Meher R: Acinic cell carcinoma with extensive neuroendocrine differentiation: a diagnostic challenge. Head Neck Pathol; 2009 Jun;3(2):163-8
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  • Amongst the various reported primary tumors with neuroendocrine differentiation, acinic cell carcinoma (ACC) one such tumor.
  • Contrast Enhanced Computed Tomography (CECT) suggested diagnosis of Pleomorphic Adenoma.
  • Fine Needle Aspiration Cytology (FANC) yielded a cystic fluid suggesting a possibility of Warthin's tumor or Oncocytic lesion.
  • Intraoperative findings were suggestive of a Warthin's tumor.
  • Initial histopathological examination of the tumor was suggestive of neuroendocrine carcinoma.
  • The possibility of neuroendocrine differentiation in a primary salivary gland tumor should be kept in mind whenever a salivary gland tumor shows only neuroendocrine histology.
  • [MeSH-minor] Adenolymphoma / pathology. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 19644544.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Acinic cell / Carcinoma / Chromogranin / Neuroendocrine / Parotid / Warthin’s
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87. Ferreira PC, Amarante JM, Rodrigues JM, Pinho CJ, Cardoso MA, Reis JC: Parotid surgery: review of 107 tumors (1990-2002). Int Surg; 2005 Jul-Aug;90(3):160-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid surgery: review of 107 tumors (1990-2002).
  • Tumors of the parotid gland are uncommon.
  • We reviewed the clinical and the surgical records of a series of 109 patients who were recommended for surgery because of parotid tumors by the Plastic and Reconstructive Service of São João Hospital, Portugal, between 1990 and 2002.
  • Pleomorphic adenoma was the most common tumor (63.5%).
  • Swelling was the most frequent clinical finding.
  • Recurrent disease was seen in six patients.
  • For the majority of tumors, superficial parotidectomy is an effective treatment with acceptable morbidity.
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenolymphoma / surgery. Adenoma, Pleomorphic / epidemiology. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Child. Facial Paralysis / etiology. Female. Humans. Male. Middle Aged. Postoperative Complications / epidemiology. Retrospective Studies. Sweating, Gustatory / etiology

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  • (PMID = 16466006.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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88. Liu HX, Sun YM: [Peripheral T-cell lymphoma, NOS arising in Warthin tumor: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2008 Jun;37(6):425
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  • [Title] [Peripheral T-cell lymphoma, NOS arising in Warthin tumor: report of a case].
  • [MeSH-major] Adenolymphoma / enzymology. Lymphoma, T-Cell / enzymology. Lymphoma, T-Cell, Peripheral / enzymology. Nitric Oxide Synthase Type I / metabolism

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  • (PMID = 19031731.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 1.14.13.39 / NOS1 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase Type I
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89. Inohara H, Akahani S, Yamamoto Y, Hattori K, Tomiyama Y, Tomita Y, Aozasa K, Kubo T: The role of fine-needle aspiration cytology and magnetic resonance imaging in the management of parotid mass lesions. Acta Otolaryngol; 2008 Oct;128(10):1152-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenolymphoma / surgery. Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Carcinoma / diagnosis. Carcinoma / surgery. Cysts / diagnosis. Cysts / surgery. Diagnostic Errors. False Positive Reactions. Humans. Neoplasm Invasiveness. Preoperative Care. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 18607904.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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90. Salama AR, Ord RA: Clinical implications of the neck in salivary gland disease. Oral Maxillofac Surg Clin North Am; 2008 Aug;20(3):445-58
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  • [Title] Clinical implications of the neck in salivary gland disease.
  • Preoperative diagnostics, including imaging and fine needle aspiration, are key elements in treatment planning, even in the absence of absolute histologic confirmation of tumors.
  • Benign tumor implants in the neck can be managed with conservative surgery, whereas aggressive surgical management, including neck dissection and adjuvant therapy, is generally advocated for malignancy.
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenolymphoma / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Carcinoma / diagnosis. Carcinoma / secondary. Carcinoma / surgery. Carcinosarcoma / diagnosis. Carcinosarcoma / secondary. Carcinosarcoma / surgery. Choristoma / diagnosis. Choristoma / surgery. Humans. Lymphatic Metastasis. Neck Dissection. Parotid Neoplasms / diagnosis. Parotid Neoplasms / surgery. Ranula / diagnosis. Ranula / surgery. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / surgery

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  • (PMID = 18603202.001).
  • [ISSN] 1558-1365
  • [Journal-full-title] Oral and maxillofacial surgery clinics of North America
  • [ISO-abbreviation] Oral Maxillofac Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 89
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91. Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G: Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. Genes Chromosomes Cancer; 2005 Jun;43(2):202-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.
  • Recent studies have shown that the t(11;19)(q21;p13) translocation in mucoepidermoid carcinomas and benign Warthin's tumors results in a fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a.
  • Here we show that a third tumor type, clear cell hidradenoma of the skin, also expresses this gene fusion.
  • These results demonstrate that the t(11;19) in mucoepidermoid carcinoma, Warthin's tumor, and clear cell hidradenoma targets the same genes and results in identical gene fusions, indicating that at least subgroups of these glandular tumors evolve through activation of the same molecular pathways.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15729701.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Transcription Factors
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92. Hall JE, Statham MM, Sheridan RM, Wilson KM: Multifocal synchronous ipsilateral Warthin tumors: case report and review of the literature. Ear Nose Throat J; 2010 Sep;89(9):E1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multifocal synchronous ipsilateral Warthin tumors: case report and review of the literature.
  • Pathologic examination revealed two distinct masses, one in the superficial lobe and one in the deep lobe of the parotid gland, both consistent with synchronous Warthin tumors.
  • Although the true incidence of multicentricity in ipsilateral Warthin tumors may be underappreciated and underreported, this entity should remain in the differential diagnosis for unilateral parotid masses.
  • [MeSH-major] Adenolymphoma / complications. Adenolymphoma / diagnosis. Lymphatic Diseases / complications. Neoplasms, Multiple Primary / complications. Neoplasms, Multiple Primary / diagnosis. Parotid Neoplasms / complications. Parotid Neoplasms / diagnosis

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  • (PMID = 20859854.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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93. Mortensen KS, Hjortlund J, Bjørndal K, Krogdal A, Godballe C: [Salivary gland tumors in the County of Funen, 1984-2003]. Ugeskr Laeger; 2008 Feb 11;170(7):545-8
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  • [Title] [Salivary gland tumors in the County of Funen, 1984-2003].
  • INTRODUCTION: The objective of this study is to estimate the incidence of major salivary gland tumors in a geographically well-defined area (the County of Funen, Denmark) and to analyse the demographic data and distribution of histological types.
  • MATERIALS AND METHODS: Patients with salivary gland tumors were identified through a search on pathology and diagnosis codes in the period 1984-2003, which initially resulted in a group of 951 patients.
  • RESULTS: The incidence of major salivary gland tumors for the County of Funen is calculated to 7.3 per 100,000 residents per year.
  • Pleomorphic adenoma (55%) was the most common type, followed by adenolymphoma (29%).
  • 90% of the tumors were found in the parotid gland - 93% benign and 7% malignant.
  • The occurrence of pleomorphic adenomas among females (66%) was higher than among males (43%), on the other hand more adenolymphomas were found in males (43%) than in females (17%).
  • CONCLUSION: The incidence of major salivary gland tumors in the County of Funen is calculated to 7.3 per 100,000 inhabitants per year which is equivalent to 383 new cases in Denmark per year.
  • [MeSH-major] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 18291086.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
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94. Srivastava S, Nadelman C: Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. Diagn Cytopathol; 2010 Jul;38(7):533-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous ipsilateral Warthin tumor encased by a separate mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature.
  • Fine-needle aspiration (FNA) is a cost effective and low morbidity procedure in the initial assessment of salivary gland tumors.
  • However, cytological assessment of ipsilateral synchronous tumors (which make up less than 0.3% of all salivary gland neoplasms) may pose diagnostic challenges.
  • Here, we report a unique case of Warthin tumor encased by a separate high-grade mucoepidermoid carcinoma that was first diagnosed on FNA.
  • Traditionally, there has been diagnostic difficulty when dealing with synchronous tumors of the salivary gland and the background of chronic sialadenitis may further complicate the diagnosis.
  • [MeSH-major] Adenolymphoma / complications. Adenolymphoma / pathology. Carcinoma, Mucoepidermoid / complications. Carcinoma, Mucoepidermoid / pathology. Parotid Gland / pathology. Parotid Neoplasms / complications. Parotid Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 20027619.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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95. Sun G, Hu Q, Huang X, Tang E: Sebaceous lymphadenoma of parotid gland in a child. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Feb;107(2):253-5
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  • Sebaceous lymphadenoma is a rare tumor presenting predominantly in the parotid gland.
  • The treatment is complete surgical excision, and this tumor is rarely recurrent.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 19138644.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Teymoortash A, Werner JA: Tissue that has lost its track: Warthin's tumour. Virchows Arch; 2005 Jun;446(6):585-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tissue that has lost its track: Warthin's tumour.
  • The origin of cystadenolymphoma (Warthin's tumour) of the parotid gland is unknown.
  • According to the most favoured hypothesis, Warthin's tumour results from the proliferation of salivary gland ductal cells that were entrapped in parotid lymph nodes during embryonal life.
  • If this is correct, and the almost total lack of recurrence and malignant transformation of this lesion lends credence to this view, Warthin's tumour is correctly classified in the group of tumour-like lesions and should not be considered to be a monomorphic adenoma.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 15912361.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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97. Winnes M, Enlund F, Mark J, Stenman G: The MECT1-MAML2 gene fusion and benign Warthin's tumor: is the MECT1-MAML2 gene fusion specific to mucuepidermoid carcinoma? J Mol Diagn; 2006 Jul;8(3):394-5; author reply 395-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The MECT1-MAML2 gene fusion and benign Warthin's tumor: is the MECT1-MAML2 gene fusion specific to mucuepidermoid carcinoma?
  • [MeSH-major] Adenolymphoma / genetics. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / genetics. Oncogene Proteins, Fusion / genetics
  • [MeSH-minor] Biomarkers, Tumor. Humans. In Situ Hybridization. Sensitivity and Specificity. Translocation, Genetic

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  • (PMID = 16825514.001).
  • [ISSN] 1525-1578
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] eng
  • [Publication-type] Comment; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
  • [Other-IDs] NLM/ PMC1876653
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98. Fulciniti F, Losito NS, Ionna F, Longo F, Aversa C, Botti G, Foschini MP: Sclerosing polycystic adenosis of the parotid gland: report of one case diagnosed by fine-needle cytology with in situ malignant transformation. Diagn Cytopathol; 2010 May;38(5):368-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In line with numerous other pathological analogies between breast and salivary gland lesions, SPA shares with fibrocystic disease of the breast many histopathological features, i.e., fibrosis, oncocytic (apocrine) changes, hyperplasia of ductal and acinar epithelium, cystic dilation of ducts, and, often, atypical epithelial changes.
  • The spectrum of pathological lesions entering differential diagnosis comprised sebaceous adenoma, Warthin's tumors with presence of sebaceous remnants, and low-grade mucoepidermoid carcinoma.

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  • (PMID = 19937766.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Chikui T, Tokumori K, Yoshiura K, Oobu K, Nakamura S, Nakamura K: Sonographic texture characterization of salivary gland tumors by fractal analyses. Ultrasound Med Biol; 2005 Oct;31(10):1297-304
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sonographic texture characterization of salivary gland tumors by fractal analyses.
  • The purpose of this study was to quantify the sonographic images of salivary gland tumors.
  • The study population consisted of 21 pleomorphic adenomas, seven Warthin's tumors and 15 malignant tumors.
  • The fractal dimension by the 2-D BC method of pleomorphic adenoma was significantly larger than that of malignant tumors.
  • The FD by the 3-D BC method of pleomorphic adenoma was significantly larger than both that of Warthin's tumors and that of malignant tumors.
  • The Hurst index obtained by the F BM model of pleomorphic adenoma was significantly lower than that of the malignant tumor.
  • [MeSH-major] Adenoma / ultrasonography. Carcinoma / ultrasonography. Fractals. Image Interpretation, Computer-Assisted. Neoplasms, Multiple Primary / ultrasonography. Salivary Gland Neoplasms / ultrasonography
  • [MeSH-minor] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Diagnosis, Differential. Humans. Imaging, Three-Dimensional. Parotid Neoplasms / ultrasonography. Salivary Glands / ultrasonography. Submandibular Gland Neoplasms / ultrasonography

  • MedlinePlus Health Information. consumer health - Salivary Gland Cancer.
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  • (PMID = 16223632.001).
  • [ISSN] 0301-5629
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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100. Kara MI, Göze F, Ezirganli S, Polat S, Muderris S, Elagoz S: Neoplasms of the salivary glands in a Turkish adult population. Med Oral Patol Oral Cir Bucal; 2010 Nov;15(6):e880-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • STUDY DESIGN: The histological diagnosis records of the Department of Pathology at Cumhuriyet University were reevaluated for 125 patients who were treated for salivary gland tumors from 1987 to 2008.
  • Pleomorphic adenoma was the most frequent benign tumor followed by Warthin's tumor.
  • CONCLUSIONS: Although there were some discrepancies, the characteristics of salivary gland tumors of Turkish patients are in line with those of patients from other countries according to tumor type, tumor site distribution, and age and sex of patients.

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  • (PMID = 20526249.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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