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1. Zidar N, Gale N, Zupevc A, Dovsak D: Pseudovascular adenoid squamous-cell carcinoma of the oral cavity--a report of two cases. J Clin Pathol; 2006 Nov;59(11):1206-8
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  • [Title] Pseudovascular adenoid squamous-cell carcinoma of the oral cavity--a report of two cases.
  • Two cases of pseudovascular adenoid squamous-cell carcinoma (SCC) in the oral cavity are described, which were characterised by acantholysis of the tumour cells, with formation of anastomosing spaces and channels mimicking an angiosarcoma.
  • Both tumours contained foci of SCC suggesting the correct diagnosis: in one patient conventional SCC, and in the other, a spindle-cell carcinoma.
  • The pathogenesis of pseudovascular adenoid SCC is unknown.
  • Pseudovascular adenoid SCC is suggested to be pathogenetically related to the loss of E-cadherin expression, leading to the loss of tumour cell-cell adhesion.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Aged. Cadherins / metabolism. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism


2. Emanuel P, Wang B, Wu M, Burstein DE: p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Mod Pathol; 2005 May;18(5):645-50
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  • [Title] p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma.
  • Morphologic distinction of high-grade adenoid cystic carcinoma from basaloid squamous cell carcinoma can be difficult.
  • We have investigated the possibility that immunohistochemical staining for the presence of p63, a novel epithelial stem-cell regulatory protein, could be a useful means of distinguishing these two neoplasms.
  • Archival, routinely processed slides were subjected to citrate-based antigen retrieval, exposure to anti-p63 monoclonal 4A4, and developed with a streptavidin-biotin kit and diaminobenzidine as chromogen. p63 was detected in 100% of the adenoid cystic carcinomas (n=14) and 100% of basaloid squamous cell carcinomas (n=16).
  • Basaloid squamous cell carcinomas consistently displayed diffuse p63 positivity, with staining of nearly 100% of tumor cells.
  • In contrast, adenoid cystic carcinoma displayed a consistently compartmentalized pattern within tumor nests.
  • (1) selective staining of a single peripheral layer of p63-positive cells surrounding centrally located tumor cells that were p63-negative and (2) tumor nests consisting of multiple contiguous glandular/cribriform-like units of p63-positive cells surrounding or interspersed with p63-negative cells. p63 immunostaining constitutes a specific and accurate means of distinguishing adenoid cystic carcinoma from basaloid squamous cell carcinoma. p63 positivity in adenoid cystic carcinoma appears to be homologous to that seen in the basal and/or myoepithelial compartments of salivary gland and other epithelia, and may signify a stem-cell-like role for these peripheral cells.
  • Diffuse p63 positivity in basaloid squamous cell carcinoma suggests dysregulation of p63-positive stem cells in poorly differentiated squamous carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Phosphoproteins / analysis. Trans-Activators / analysis
  • [MeSH-minor] DNA-Binding Proteins. Diagnosis, Differential. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 15529180.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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3. Seth A, Agarwal A: Adenoid cystic carcinoma of uterine cervix in a young patient. Indian J Pathol Microbiol; 2009 Oct-Dec;52(4):543-5
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  • [Title] Adenoid cystic carcinoma of uterine cervix in a young patient.
  • Adenoid cystic carcinoma of uterine cervix is a rare tumor.
  • An association with squamous cell carcinoma has been described.
  • We report a case of adenoid cystic carcinoma of the endocervical canal with foci of squamous cell carcinoma in a 34-year-old suffering from menorrhagia associated with blood-stained vaginal discharge.
  • Cervical biopsy showed bits of tissue, suggesting adenoid cystic carcinoma.
  • We report this case because of its rarity, particularly in young patients, with description of illustrative pathology and discussion on the histological diagnosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / pathology


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4. Balica N, Raica M, Cotulbea S, Doros C: Mast cell reaction in malignant laryngeal neoplasm. Rom J Morphol Embryol; 2007;48(4):395-401

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  • [Title] Mast cell reaction in malignant laryngeal neoplasm.
  • Mast cell hyperplasia was found in many malignant tumors, but the significance of this phenomenon is still unknown.
  • In the literature, there are few data about mast cell reaction in malignant laryngeal neoplasm.
  • For histological diagnosis two sections were prepared for Hematoxylin-Eosin staining and Alcian blue-Safranin histochemistry at pH 0.2 for identifying mast cells.
  • RESULTS: Most of the cases were squamous cell carcinoma G1 - 24.4%, G2 - 56.69%, G3 - 18.11%, and 0.78% adenoid cystic carcinoma.
  • Invasive squamous cell carcinoma mast cell microdensity was 2.19 and 4.66 in microinvasive squamous cell carcinoma.
  • Mast cell microdensity in malignant laryngeal papillomatosis was 9.33 and 46.66 in adenoid cystic carcinoma.
  • In carcinoma-associated mast cell hyperplasia, the large majority of mast cells were Alcian blue positive.
  • CONCLUSIONS: In early stages, the mast cells are numerous (microinvasive squamous cell carcinoma mast cell microdensity 4.66) and rare or even absent in late stages (invasive squamous cell carcinoma mast cell microdensity 2.19).
  • Mast cell microdensity in malignant laryngeal papillomatosis was 9.33 and 46.66 in cystic carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Laryngeal Neoplasms / pathology. Mast Cells / pathology
  • [MeSH-minor] Humans. Necrosis. Neoplasm Invasiveness. T-Lymphocytes / pathology

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  • (PMID = 18060190.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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5. González-Vela MC, Val-Bernal JF, Mayorga M, Zaldumbide L, Báscones M: Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma. APMIS; 2006 Jun;114(6):470-3
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  • [Title] Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma.
  • Adenoid squamous cell carcinoma (ASCC) or acantholytic squamous cell carcinoma is a well-recognized variant of squamous cell carcinoma.
  • Biopsy was performed and the histological diagnosis was squamous cell carcinoma.
  • Microscopically, the tumor showed a prominent alveolar pattern with cystic degeneration of the neoplastic epithelium and formation of pseudoglandular structures.
  • In the lumina there were acantholytic cells.
  • Transition areas from conventional squamous cell carcinoma to adenoid pattern were found.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 16856971.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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6. Guo XL, Wei FC, Sun SZ: [Clinical study of oral and maxillofacial malignancies associated with multiple primary malignant neoplasms]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2006 Feb;24(1):42-4
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  • [Title] [Clinical study of oral and maxillofacial malignancies associated with multiple primary malignant neoplasms].
  • OBJECTIVE: To study the clinical characteristics, diagnosis and treatment strategy of oral and maxillofacial malignancies in multiple primary malignant neoplasms (MPMNs).
  • RESULTS: There were 44 malignant cases in the 21 MPMNs patients.
  • There were 25 cases malignant neoplasms in oral and maxillofacial region where squamous cell carcinoma was the most common pathologic type, secondly adenoid cystic carcinoma.
  • Regular follow-up, early detection, early diagnosis, active and effective treatment can help to improve the survival quality of MPMNs patients.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Carcinoma, Squamous Cell. Mouth Neoplasms. Neoplasms, Multiple Primary

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  • (PMID = 16541654.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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7. González-García R, Nam-Cha SH, Muñoz-Guerra MF, Gamallo-Amat C: Basal cell adenoma of the parotid gland. Case report and review of the literature. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E206-9

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  • [Title] Basal cell adenoma of the parotid gland. Case report and review of the literature.
  • Basal cell adenoma of the salivary glands is an uncommon type of monomorphous adenoma.
  • Due to prognostic implications, differential diagnosis with basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell carcinoma is mandatory.
  • We describe a case of basal cell adenoma of the parotid gland.
  • We also review the literature and discuss the diagnosis and management of this rare entity.

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  • (PMID = 16505803.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 21
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8. Eslami B, Rahimi H, Rahimi F, Khiavi MM, Ebadifar A: Diagnostic value of silver nitrate staining for nucleolar organizer regions in selected head and neck tumors. J Cancer Res Ther; 2006 Jul-Sep;2(3):129-31
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  • BACKGROUND: The present study is aimed to assess the usefulness of silver nitrate staining of nucleolar organizer regions (NORs) as a quantitative criterion for the diagnosis of selected head and neck tumors.
  • The samples consisted of 21 squamous cell carcinoma (SCC) of larynx, 28 SCC of oral mucosa and 36 samples of most common salivary gland tumors.
  • RESULTS: A significant difference was seen in the number of AgNOR dots between oral and laryngeal SCC with surrounding dysplastic and normal tissues (P < 0.001) and also between mucoepidermoid carcinoma and adenoid cystic carcinoma with pleomorphic adenoma and normal salivary gland tissue (P < 0.001).
  • CONCLUSION: The silver nitrate staining for NORs is a useful method for aiding the diagnosis of malignant and dysplastic mucosal lesions and also malignant and benign salivary gland tumors.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Head and Neck Neoplasms / diagnosis. Nucleolus Organizer Region / metabolism. Silver Staining
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Humans. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17998691.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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9. Kusafuka K, Ebihara M, Ishiki H, Takizawa Y, Iida Y, Onitsuka T, Takakuwa R, Kasami M, Ito I, Kameya T: Primary adenoid squamous cell carcinoma of the oral cavity. Pathol Int; 2006 Feb;56(2):78-83
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  • [Title] Primary adenoid squamous cell carcinoma of the oral cavity.
  • Adenoid squamous cell carcinoma (ASCC) is an uncommon but well-recognized variant of squamous cell carcinoma that was first described by Lever in 1947.
  • The biopsy material was diagnosed as squamous cell carcinoma.
  • Histologically, most parts of the lesion were conventional squamous cell carcinoma in situ, but the invasive part consisted of ASCC with gland-like or reticular appearance.
  • The Ki-67 labeling index was 50.3% in the ASCC part and 34.5% in the carcinoma in situ part.
  • These findings and a review of the literature indicate that a gland-like feature of ASCC is associated with the loss of cell adhesion in the center of the cancer nests, and it can be confirmed simply by mucin staining to be neither an adenosquamous carcinoma nor ductal involvement of conventional squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Cadherins / analysis. Carcinoma, Adenosquamous / chemistry. Carcinoma, Adenosquamous / diagnosis. Carcinoma, Adenosquamous / pathology. Carcinoma, Mucoepidermoid / chemistry. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Cell Adhesion. Cell Proliferation. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Middle Aged. Mucins / analysis. Tumor Suppressor Protein p53 / analysis


10. Papadopoulou E, Tosios KI, Nikitakis N, Papadogeorgakis N, Sklavounou-Andrikopoulou A: Acantholytic squamous cell carcinoma of the gingiva: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jun;109(6):e67-71
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  • [Title] Acantholytic squamous cell carcinoma of the gingiva: report of a case and review of the literature.
  • Adenoid squamous cell carcinoma differs from common squamous cell carcinoma in histologic features and its aggressive nature.
  • Microscopically, the tumor shows cystic degeneration of the neoplastic epithelium, producing a prominent alveolar pattern and pseudoglandular structures with acantholytic cells.
  • An incisional biopsy rendered the diagnosis of adenoid squamous cell carcinoma.
  • [MeSH-major] Acantholysis / pathology. Carcinoma, Squamous Cell / pathology. Gingival Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20451835.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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11. Prasad KK, Kaur S: Acantholytic squamous cell carcinoma of the oral cavity: an uncommon histological variant of squamous cell carcinoma. Minerva Stomatol; 2010 Jun;59(6):377-80
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  • [Title] Acantholytic squamous cell carcinoma of the oral cavity: an uncommon histological variant of squamous cell carcinoma.
  • Acantholytic squamous cell carcinoma is a rare and aggressive histological variant of squamous cell carcinoma, characterized by tubular and alveolar patterns as a consequence of the acantholysis.
  • We report a case of acantholytic squamous cell carcinoma in a 70-year-old woman, who was admitted to our institution for the progressively enlarging exophytic and ulcerated lesion.
  • We report this interesting lesion due to the rarity of acantholytic variant of squamous cell carcinoma and the literature is briefly reviewed.
  • [MeSH-major] Carcinoma, Squamous Cell / prevention & control. Mouth Neoplasms / pathology


12. Horn LC, Liebert UG, Edelmann J, Höckel M, Einenkel J: Adenoid squamous carcinoma (pseudoangiosarcomatous carcinoma) of the vulva: a rare but highly aggressive variant of squamous cell carcinoma-report of a case and review of the literature. Int J Gynecol Pathol; 2008 Apr;27(2):288-91
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  • [Title] Adenoid squamous carcinoma (pseudoangiosarcomatous carcinoma) of the vulva: a rare but highly aggressive variant of squamous cell carcinoma-report of a case and review of the literature.
  • Pseudoangiosarcomatous squamous cell carcinoma is an unusual but aggressive variant of acantholytic squamous cell carcinoma of the vulva that mimics angiosarcoma on histology.
  • We present a case of a 57-year-old woman with bilateral inguinal metastatic disease at the time of diagnosis, who died 4 months later because of distant metastatic disease to the lungs.
  • Because of the positive p53 immunostaining and the association to lichen sclerosus and simple type of high-grade vulvar intraepithelial neoplasia, alteration of p53 tumor suppressor gene might be involved in the pathogenesis of vulvar pseudoangiosarcomatous squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Hemangiosarcoma / diagnosis. Hemangiosarcoma / metabolism. Hemangiosarcoma / pathology. Humans. Middle Aged. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 18317210.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
  • [Number-of-references] 16
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13. Kerawala CJ: Acantholytic squamous cell carcinoma of the oral cavity: a more aggressive entity? Br J Oral Maxillofac Surg; 2009 Mar;47(2):123-5
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  • [Title] Acantholytic squamous cell carcinoma of the oral cavity: a more aggressive entity?
  • Acantholytic squamous cell carcinoma is a histologically distinct variant of squamous cell carcinoma that arises most commonly in areas of the skin exposed to the sun.
  • It is rare on mucosal surfaces of the upper aerodigestive tract, where there is some suggestion that it might behave more aggressively than conventional squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Acantholysis. Fatal Outcome. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 18565630.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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14. Stelow EB, Mills SE: Squamous cell carcinoma variants of the upper aerodigestive tract. Am J Clin Pathol; 2005 Dec;124 Suppl:S96-109
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  • [Title] Squamous cell carcinoma variants of the upper aerodigestive tract.
  • Squamous cell carcinoma (SCC) is by far the most common malignancy of the upper aerodigestive tract.
  • Certain variants, however, can histologically mimic benign and other malignant diseases.
  • In such cases, correct diagnosis is important for prognostic and therapeutic reasons.
  • This article discusses the clinicopathologic features of the upper aerodigestive tract variants of SCC, including verrucous carcinoma, papillary squamous cell carcinoma, basaloid squamous cell carcinoma, spindle cell carcinoma, adenosquamous carcinoma, adenoid squamous cell carcinoma, and undifferentiated carcinoma.
  • It also discusses the differential diagnoses that must be considered and the use of ancillary testing, especially immunohistochemical analysis, for determining the correct diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Digestive System Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Adenosquamous / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Papillary / pathology. Humans

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  • (PMID = 16468420.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 109
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15. Du X, Yin X, Zhou N, Zhang G, Shi H, Cao S: Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report. J Cutan Pathol; 2010 Jun;37(6):683-6
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  • [Title] Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report.
  • BACKGROUND: Extramammary Paget's disease (EMPD) is an uncommon skin neoplasm characterized by Paget's cells with pale-staining cytoplasm in the epidermis, and cases with distinguished acantholysis but lacking characteristic Paget's cells were rarely reported in the literature.
  • METHODS: An 80-year-old male with lesion on scrotum was screened histologically and immunohistologically for the diagnosis of his tumor.
  • RESULTS: Histological examination showed acanthosis with cellular atypia and focal acantholysis, consistent with acantholytic squamous cell carcinoma in situ (SCCIS).
  • CONCLUSIONS: These findings strongly indicated the diagnosis of EMPD mimicking acantholytic SCCIS.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Genital Neoplasms, Male / pathology. Paget Disease, Extramammary / pathology. Scrotum / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 19615013.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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16. Conde-Taboada A, Flórez A, De la Torre C, Feal C, García-Doval I, Cruces M: Pseudoangiosarcomatous squamous cell carcinoma of skin arising adjacent to decubitus ulcers. Am J Dermatopathol; 2005 Apr;27(2):142-4
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  • [Title] Pseudoangiosarcomatous squamous cell carcinoma of skin arising adjacent to decubitus ulcers.
  • Pseudoangiosarcomatous, or pseudovascular, squamous cell carcinoma of skin is an unusual form of acantholytic (adenoid, pseudoglandular) squamous cell carcinoma that mimics the histolopathologic appearance of angiosarcoma.
  • We report a case of pseudoangiosarcomatous squamous cell carcinoma arising adjacent to decubitus ulcers.
  • To our knowledge, our patient is the first with pseudoangiosarcomatous squamous cell carcinoma of skin developing within decubitus ulcer.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Pressure Ulcer / complications. Skin Neoplasms / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Immunohistochemistry

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  • (PMID = 15798440.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Mercader P, Torrijos A, Sánchez-Carazo JL, Fortea JM: [Pseudovascular squamous cell carcinoma]. Actas Dermosifiliogr; 2006 May;97(4):257-9
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  • [Title] [Pseudovascular squamous cell carcinoma].
  • [Transliterated title] Carcinoma epidermoide pseudovascular.
  • The adenoid form of squamous cell carcinoma is a neoplasm that is characterized by the fact that it presents a pseudoglandular pattern in the histological study.
  • The biological phenomenon that explains this histological pattern is acantholysis; when the latter is massive, the tumor may even mimic a vascular proliferation, and is known as pseudovascular squamous cell carcinoma.
  • This tumor has the clinical characteristics of a squamous cell carcinoma, but histologically, it may mimic an angiosarcoma.
  • Most cases of pseudovascular squamous cell carcinoma of the skin have a poor prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Head and Neck Neoplasms / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Hemangiosarcoma / diagnosis. Humans. Lymphatic Metastasis / radiotherapy. Male. Remission Induction

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  • (PMID = 16801019.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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18. Aulmann S, Schnabel PA, Helmchen B, Dienemann H, Drings P, Otto HF, Sinn HP: Immunohistochemical and cytogenetic characterization of acantholytic squamous cell carcinoma of the breast. Virchows Arch; 2005 Mar;446(3):305-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical and cytogenetic characterization of acantholytic squamous cell carcinoma of the breast.
  • Primary acantholytic squamous cell carcinoma (ASCC) of the breast is a rare and aggressive variant of invasive breast cancer.
  • The results of our analyses suggest that genetic alterations observed in ASCC of the breast include imbalances commonly observed in both mammary adenocarcinoma and squamous cell carcinoma of other locations.
  • [MeSH-major] Bone Neoplasms / secondary. Breast Neoplasms / genetics. Breast Neoplasms / pathology. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. DNA, Neoplasm / genetics


19. Zhang JP, Li CY: [The effect of transforming growth factor-beta1 on EDA region of fibronectin in oral squamous cell carcinoma and adenoid cystic carcinoma cells]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2007 Jan;42(1):47-51
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  • [Title] [The effect of transforming growth factor-beta1 on EDA region of fibronectin in oral squamous cell carcinoma and adenoid cystic carcinoma cells].
  • OBJECTIVE: To investigate the effect of transforming growth factor-beta1 (TGF-beta1) on EDA region of fibronectin in oral squamous cell carcinoma and adenoid cystic carcinoma cells.
  • In the three oral carcinoma cells, the expression of EDA(+) mRNAs in the group with TGF-beta1 was higher than that in the group without TGF-beta1 (P < 0.05).
  • CONCLUSIONS: TGF-beta1 could influence EDA region splicings and upregulate the expression of EDA region in Tca83, SACC-83 and SACC-LM cells, and might play an important role in accelerating oral carcinoma cells adhesion and tumor invasion and metastasis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / pathology. Fibronectins / metabolism. Mouth Neoplasms / pathology. Transforming Growth Factor beta1 / pharmacology
  • [MeSH-minor] Cell Line, Tumor. Humans. RNA, Messenger / metabolism

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  • (PMID = 17331445.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Fibronectins; 0 / RNA, Messenger; 0 / Transforming Growth Factor beta1
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20. Chetty R, Serra S, Hsieh E: Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant. Am J Surg Pathol; 2005 Dec;29(12):1668-72
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  • [Title] Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant.
  • Two cases of a distinctive variety of basaloid squamous carcinoma (BSC) of the anal canal are described.
  • Accompanying dysplasia of the overlying squamous mucosa was absent.
  • This appearance together with microcystic spaces simulated that of an adenoid cystic carcinoma.
  • BSC of the anal canal with an adenoid cystic pattern is an infrequently encountered and reported variant, although it is seen more often in the aerodigestive tract.
  • There may be an increased propensity for BSC with an adenoid cystic pattern to metastasize to the liver, but the number of cases encountered are too small to be definitive.
  • The histologic differential diagnosis is true salivary gland-type adenoid cystic carcinoma and basal cell adenocarcinoma.
  • Immunohistochemistry and awareness of this unusual pattern of BSC will facilitate the correct diagnosis being reached.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Basosquamous / pathology
  • [MeSH-minor] Antibiotics, Antineoplastic / therapeutic use. Antigens, CD20 / metabolism. Antimetabolites, Antineoplastic / therapeutic use. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cisplatin / therapeutic use. DNA-Binding Proteins. Female. Fluorouracil / therapeutic use. Follow-Up Studies. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Keratins / metabolism. Middle Aged. Mitomycin / therapeutic use. Phosphoproteins / metabolism. Radiotherapy. Time Factors. Trans-Activators / metabolism. Transcription Factors. Treatment Outcome. Tumor Burden. Tumor Suppressor Proteins

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  • (PMID = 16327441.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antigens, CD20; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 50SG953SK6 / Mitomycin; 68238-35-7 / Keratins; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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21. Aksu K, Aktaş Z, Aksu F, Orsel O, Demirağ F, Sipit T, Firat Güven S: Spindle cell sarcomatoid carcinoma: first case reported in the trachea. Tuberk Toraks; 2009;57(3):337-41

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  • [Title] Spindle cell sarcomatoid carcinoma: first case reported in the trachea.
  • Microscopically, the tumor was composed of fascicular pattern of spindle cells with atypical mitotic figures and nuclear pleomorphism, positively reactive to epithelial membrane antigen supporting a diagnosis of tumour with epithelial differentiation.
  • These findings supported the diagnosis of a spindle cell sarcomatoid carcinoma of trachea.
  • Spindle cell carcinoma cases are reported in many sites, such as head and neck region, larynx, digestive tract, breast, kidney, genital tract, skin and lung, but to our knowledge, not in trachea.
  • Primary malignant tracheal tumours consist mainly of squamous cell carcinoma and adenoid cystic carcinoma and generally have an aggressive course with poor prognosis.
  • We report the first presentation of a spindle cell sarcomatoid carcinoma of trachea together with the clinical course of the patient.
  • [MeSH-major] Carcinoma / pathology. Tracheal Neoplasms / pathology

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  • (PMID = 19787474.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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22. Cunha IW, Guimaraes GC, Soares F, Velazquez E, Torres JJ, Chaux A, Ayala G, Cubilla AL: Pseudoglandular (adenoid, acantholytic) penile squamous cell carcinoma: a clinicopathologic and outcome study of 7 patients. Am J Surg Pathol; 2009 Apr;33(4):551-5
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  • [Title] Pseudoglandular (adenoid, acantholytic) penile squamous cell carcinoma: a clinicopathologic and outcome study of 7 patients.
  • Almost half of penile squamous cell carcinomas (SCCs) are of the usual type but there is a variegated spectrum of morphologically distinctive subtypes.
  • In a pathologic review of 375 uniformly diagnosed and treated patients with penile SCC, we found 7 tumors with predominant pseudoglandular or adenoid features.
  • The aim of the study was to delineate clinicopathologic features and outcome of an unusual variant of penile SCC.
  • Microscopically, tumors were SCC with acantholytic areas ranging from solid nests with early necrosis or empty pseudoluminal spaces lined by 1 layer of squamous cells or cylindrical cells strikingly simulating glands.
  • The differential diagnosis was with gland forming penile tumors (surface adenosquamous, mucoepidermoid, and urethral adenocarcinomas) and the angiosarcomatoid variant of sarcomatoid carcinomas.
  • The other 5 were either alive with no evidence of disease (12 and 21 y after diagnosis) or died from causes other than penile cancer (3, 4, and 7 y after diagnosis).
  • Comparing with usual SCCs, pseudoglandular SCCs were of higher grade (88% vs. 44%), invaded deeper into CC (71% vs. 52%), and showed a higher incidence of regional metastasis (42% vs. 25%) and higher mortality (29% vs. 19%).
  • [MeSH-major] Acantholysis / pathology. Carcinoma, Squamous Cell / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Treatment Outcome

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  • [CommentIn] Am J Surg Pathol. 2009 Sep;33(9):1421-2 [19609203.001]
  • (PMID = 19033863.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Teramoto N, Nishimura R, Saeki T, Nogawa T, Hiura M: Adenoid basal carcinoma of the uterine cervix: report of two cases with reference to adenosquamous carcinoma. Pathol Int; 2005 Jul;55(7):445-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid basal carcinoma of the uterine cervix: report of two cases with reference to adenosquamous carcinoma.
  • Adenoid basal carcinoma (ABC) of the uterine cervix is a rare neoplasm with excellent prognosis.
  • Differential diagnosis between ABC and an ABC-like lesion of adenosquamous cell carcinoma (ASC) of the cervix is important due to their contrasting prognosis.
  • The two ABC were incidentally found in the uterine cervix of 69-year-old and 59-year-old Japanese women due to cervical intraepithelial neoplasia grade 3 and to squamous cell carcinoma, respectively.
  • An ABC-like lesion was defined as basaloid cell nests simulating ABC, but with some features indicating malignant potential.
  • However, the differential diagnosis was sometimes difficult because two of seven ABC-like lesions were originally diagnosed as ABC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenosquamous / pathology. Carcinoma, Basal Cell / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-7. Keratin-8. Keratins / analysis. Ki-67 Antigen / analysis. Middle Aged

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  • (PMID = 15982222.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / KRT7 protein, human; 0 / KRT8 protein, human; 0 / Keratin-7; 0 / Keratin-8; 0 / Ki-67 Antigen; 68238-35-7 / Keratins
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24. Parwani AV, Smith Sehdev AE, Kurman RJ, Ronnett BM: Cervical adenoid basal tumors comprised of adenoid basal epithelioma associated with various types of invasive carcinoma: clinicopathologic features, human papillomavirus DNA detection, and P16 expression. Hum Pathol; 2005 Jan;36(1):82-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cervical adenoid basal tumors comprised of adenoid basal epithelioma associated with various types of invasive carcinoma: clinicopathologic features, human papillomavirus DNA detection, and P16 expression.
  • Adenoid basal tumors are uncommon cervical lesions that some pathologists consider invasive carcinomas but others consider "epitheliomas" due to their low-grade histological appearance and rarely documented malignant behavior.
  • We report the clinicopathologic features of 10 tumors comprised of both typical low-grade adenoid basal tumors (epitheliomas) intimately associated with invasive carcinomas having infiltrative growth, increased cytological atypia and mitotic activity, and various types of differentiation, including adenoid basal/squamous, pure squamous, adenoid cystic, and small cell neuroendocrine.
  • The initial diagnosis was made on specimens obtained by cervical biopsy, laser electrocautery excision procedure (LEEP), or cone biopsy in 8 patients.
  • All 10 patients had squamous intraepithelial lesions (9 high-grade, 1 low-grade).
  • In all cases diagnosed in LEEP or cone biopsy specimens, the invasive carcinoma component was present in the excisional specimen and extended to the margins.
  • One patient with a component of small cell carcinoma died of other causes without evidence of disease at 18 months.
  • HPV 16 DNA was detected in both the adenoid basal epithelioma and invasive carcinoma components in 9 tumors by in situ hybridization, and HPV 33 was detected by polymerase chain reaction in 1 tumor.
  • Adenoid basal tumors are high-risk HPV-related tumors that can be comprised of both a low-grade adenoid basal tumor, which can be designated as epithelioma, and invasive carcinomas of various types.
  • [MeSH-major] Carcinoma, Basal Cell / classification. Carcinoma, Basal Cell / pathology. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. DNA, Viral / isolation & purification. Uterine Cervical Neoplasms / classification. Uterine Cervical Neoplasms / pathology

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  • (PMID = 15712186.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral
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25. Quintyn-Ranty ML, Escourrou G, Guilbeau C, Rimailho J, Delisle MB: [Vaginal adenoid cystic carcinoma: a case report]. Ann Pathol; 2008 Apr;28(2):135-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Vaginal adenoid cystic carcinoma: a case report].
  • Adenoid cystic carcinoma generally arises from the salivary glands and is rarely found in the female genital tract.
  • Differential diagnosis includes adenoid basal carcinoma, polymorphous low-grade adenocarcinoma and basaloid squamous cell carcinoma.
  • We report a case of adenoid cystic carcinoma in a 48-year-old woman with previous cervical HPV infection.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 18675169.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Actins
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26. Clough A, Clarke P: Adenoid cystic carcinoma of the trachea: a long-term problem. ANZ J Surg; 2006 Aug;76(8):751-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the trachea: a long-term problem.
  • Adenoid cystic carcinoma of the trachea, although rare, is the second most common primary tumour of the trachea.
  • It is a slow-growing tumour found in younger patients than the more common squamous cell carcinoma and is relatively resistant to treatment, but metastasizes late in the course of disease and even in unresectable cases can be palliated successfully for many years.
  • Details collected included symptoms before diagnosis, length of time from onset of the first symptom to diagnosis, resection details, survival statistics and accessory procedures tried before and after consideration of resection.
  • The mean time of diagnosis from the onset of symptoms was 16 months.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / therapy. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / therapy. Palliative Care. Tracheal Neoplasms / diagnosis. Tracheal Neoplasms / therapy

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  • (PMID = 16916400.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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27. Chen CH, Rowlands C, Sengupta SK, George RL, Parulekar W, Thain K, O'Malley F, Isotalo PA: Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ. Breast J; 2009 Jul-Aug;15(4):409-13
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  • [Title] Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ.
  • We describe a primary invasive adenocarcinoma of the nipple with extensive basaloid features that was also associated with squamous cell carcinoma (SCC) in situ and an aggressive behavior.
  • Biopsy of the nipple revealed SCC in situ.
  • SCC in situ was present in the overlying epidermis.
  • The differential diagnosis included a primary basaloid adenocarcinoma of the nipple, basal cell carcinoma of the nipple, neuroendocrine carcinoma, melanoma, basaloid variant of adenoid cystic carcinoma and metastatic disease.
  • Although the initial sentinel lymph node biopsy was negative, within a year of diagnosis, the patient developed ipsilateral axillary node and pulmonary metastases.
  • To the best of our knowledge, this is the first case of basaloid carcinoma to be documented in this anatomic site.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Nipples / pathology

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  • (PMID = 19601946.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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28. Ichi T, Shiroma H, Arakaki K, Isa T: [A case of adenoid cystic carcinoma of the thoracic esophagus after neoadjuvant chemotherapy]. Nihon Shokakibyo Gakkai Zasshi; 2010 Feb;107(2):227-32
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  • [Title] [A case of adenoid cystic carcinoma of the thoracic esophagus after neoadjuvant chemotherapy].
  • A 60-year-old man was admitted to our hospital with a tumor in the thoracic esophagus, and squamous cell carcinoma was detected by endoscopic biopsy.
  • The resected specimen showed no residual squamous cell carcinoma but another tumor was found in the submucosal layer which had a cribiform pattern in a solid nest.
  • The tumor cells were positive for S-100 protein and an Alcian-blue-positive substance in the gland, so the tumor was diagnosed as an adenoid-cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Humans. Male. Middle Aged. Neoadjuvant Therapy

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  • (PMID = 20134125.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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29. Joshi D, Shivkumar VB, Sharma SM, Gangane N: Cytomorphologic diagnosis of basaloid squamous cell carcinoma: a case report. Acta Cytol; 2009 Jan-Feb;53(1):89-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphologic diagnosis of basaloid squamous cell carcinoma: a case report.
  • BACKGROUND: Basaloid squamous cell carcinoma is a high-grade variant of squamous cell carcinoma that most commonly occurs in the upper aerodigestive tract.
  • The authors describe the cytologic features of a histologically confirmed case of basaloid squamous cell carcinoma arising in the floor of the mouth.
  • Extracellular basement membrane-like material was also noted, which led to the erroneous diagnosis of adenoid cystic carcinoma.
  • Histopathology characteristically revealed the presence of squamoid nests between malignant basaloid cells, and the tumor was finally diagnosed as basaloid squamous cell carcinoma.
  • CONCLUSION: Basaloid squamous cell carcinoma should be considered in the differential diagnosis of tumors arising in oral cavity.
  • Cytologic diagnosis may be difficult, but careful search for a second cell population of squamoid cells in addition to small basaloid cells may aid in rendering the correct diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Middle Aged

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  • (PMID = 19248560.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Campos MS, Modolo F, de Oliveira JS, Pinto-Júnior DS, de Sousa SC: Atypical presentation of oral basaloid squamous cell carcinoma. J Contemp Dent Pract; 2009;10(2):98-104
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  • [Title] Atypical presentation of oral basaloid squamous cell carcinoma.
  • AIM: The purpose of this report is to present the clinical and histological features of a basaloid squamous cell carcinoma (BSCC) occurring in the retromolar trigone of a 59-year-old man and to relate its immunohistochemical characteristics.
  • BACKGROUND: BSCC is an aggressive distinct variant of squamous cell carcinoma (SCC) requiring recognition as a separate entity from SCC due to its peculiar behavior.
  • SUMMARY: Since this tumor can mimic other neoplasms such as adenoid cystic carcinoma, neuroendocrine carcinoma, and basal cell adenocarcinoma, histological features are essential to differentiate between them.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Transitional Cell / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Cell Nucleus / ultrastructure. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Keratins / analysis. Ki-67 Antigen / analysis. Laminin / analysis. Male. Middle Aged. Mitosis. Necrosis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 19279978.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Laminin; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins
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31. Stelow EB, Jo VY, Stoler MH, Mills SE: Human papillomavirus-associated squamous cell carcinoma of the upper aerodigestive tract. Am J Surg Pathol; 2010 Jul;34(7):e15-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus-associated squamous cell carcinoma of the upper aerodigestive tract.
  • The association of human papillomavirus with the development of head and neck squamous cell carcinomas has been better elucidated over the past 20 years.
  • We discuss the clinical and pathologic features of human papillomavirus-associated squamous cell carcinomas of the head and neck.
  • Finally, a detailed discussion is provided regarding the differential diagnosis that must be considered when confronting these squamous neoplasms.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Head and Neck Neoplasms / virology. Papillomaviridae / isolation & purification. Papillomavirus Infections / complications
  • [MeSH-minor] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Small Cell / diagnosis. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / therapy. Hypopharyngeal Neoplasms / virology. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / therapy. Laryngeal Neoplasms / virology. Male. Middle Aged. Oropharyngeal Neoplasms / pathology. Oropharyngeal Neoplasms / therapy. Oropharyngeal Neoplasms / virology. Prognosis

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  • (PMID = 20534998.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 81
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32. Cassarino DS, Derienzo DP, Barr RJ: Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two. J Cutan Pathol; 2006 Apr;33(4):261-79
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two.
  • Cutaneous squamous cell carcinoma (SCC) includes many subtypes with widely varying clinical behaviors, ranging from indolent to aggressive tumors with significant metastatic potential.
  • However, the tendency for pathologists and clinicians alike is to refer to all squamoid neoplasms as generic SCC.
  • Therefore, we have proposed the following based upon the malignant potential of SCC variants, separating them into categories of low (< or = 2% metastatic rate), intermediate (3-10%), high (greater than 10%), and indeterminate behavior.
  • Low-risk SCCs include SCC arising in actinic keratosis, HPV-associated SCC, tricholemmal carcinoma, and spindle cell SCC (unassociated with radiation).
  • Intermediate-risk SCCs include adenoid (acantholytic) SCC, intraepidermal epithelioma with invasion, and lymphoepithelioma-like carcinoma of the skin.
  • High-risk subtypes include de novo SCC, SCC arising in association with predisposing factors (radiation, burn scars, and immunosuppression), invasive Bowen's disease, adenosquamous carcinoma, and malignant proliferating pilar tumors.
  • The indeterminate category includes signet ring cell SCC, follicular SCC, papillary SCC, SCC arising in adnexal cysts, squamoid eccrine ductal carcinoma, and clear-cell SCC.
  • Subclassification of SCC into these risk-based categories, along with enumeration of other factors including tumor size, differentiation, depth of invasion, and perineural invasion will provide prognostically relevant information and facilitate the most optimal treatment for patients.
  • [MeSH-major] Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology
  • [MeSH-minor] Dermatology / methods. Diagnosis, Differential. Humans. Neoplastic Processes. Pathology, Surgical / methods. Risk Factors


33. Cassarino DS, Derienzo DP, Barr RJ: Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one. J Cutan Pathol; 2006 Mar;33(3):191-206
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one.
  • Cutaneous squamous cell carcinoma (SCC) includes many subtypes with widely varying clinical behaviors, ranging from indolent to aggressive tumors with significant metastatic potential.
  • However, the tendency for pathologists and clinicians alike is to refer to all squamoid neoplasms as generic SCC.
  • Therefore, we have proposed the following based upon the malignant potential of SCC variants, separating them into categories of low (< or = 2% metastatic rate), intermediate (3-10%), high (greater than 10%), and indeterminate behavior.
  • Low-risk SCCs include SCC arising in actinic keratosis, HPV-associated SCC, tricholemmal carcinoma, and spindle cell SCC (unassociated with radiation).
  • Intermediate-risk SCCs include adenoid (acantholytic) SCC, intraepidermal epithelioma with invasion, and lymphoepithelioma-like carcinoma of the skin.
  • High-risk subtypes include de novo SCC, SCC arising in association with predisposing factors (radiation, burn scars, and immunosuppression), invasive Bowen's disease, adenosquamous carcinoma, and malignant proliferating pilar tumors.
  • The indeterminate category includes signet ring cell SCC, follicular SCC, papillary SCC, SCC arising in adnexal cysts, squamoid eccrine ductal carcinoma, and clear-cell SCC.
  • Subclassification of SCC into these risk-based categories, along with enumeration of other factors including tumor size, differentiation, depth of invasion, and perineural invasion will provide prognostically relevant information and facilitate the most optimal treatment for patients.
  • [MeSH-major] Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology
  • [MeSH-minor] Dermatology / methods. Diagnosis, Differential. Humans. Neoplastic Processes. Pathology, Surgical / methods. Risk Factors

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  • (PMID = 16466506.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 234
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34. Bekavac-Beslin M, Mijić A, Matejcić A, Ferencić Z: Basaloid squamous cell carcinoma of the esophagus: a case report. Tumori; 2005 Jan-Feb;91(1):87-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma of the esophagus: a case report.
  • Basaloid squamous cell carcinoma (BSCC) of the esophagus is an extremely rare tumor which should be differentiated from adenoid cystic and small cell undifferentiated carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / therapy

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  • (PMID = 15850013.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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35. Ojiri H: Perineural spread in head and neck malignancies. Radiat Med; 2006 Jan;24(1):1-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although representative histologies are squamous cell carcinoma and adenoid cystic carcinoma, other malignancies such as malignant lymphoma and sarcoma also can show such a specific pattern of extent.
  • PNS can be insidious, often delaying diagnosis.
  • Knowledge of anatomy of the nerves is crucial in the imaging diagnosis of PNS, to detect early curable disease.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Cranial Nerve Neoplasms / secondary. Head and Neck Neoplasms / pathology

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  • (PMID = 16715655.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 12
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36. Qureshi SS, Chaukar DA, Talole SD, Dcruz AK: Clinical characteristics and outcome of non-squamous cell malignancies of the maxillary sinus. J Surg Oncol; 2006 Apr 1;93(5):362-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical characteristics and outcome of non-squamous cell malignancies of the maxillary sinus.
  • BACKGROUND AND OBJECTIVES: A significant paucity of data exists on non-squamous cancers of the maxillary sinus.
  • METHODS: Retrospective review of 42 patients with complete available data and a diagnosis of non-squamous cancer of the maxillary sinus treated with curative intent between 1994 and 1999 were performed.
  • Survival was also compared with that of squamous cancers of the maxillary sinus.
  • Malignancies were 14 sarcomas, 8 adenoid cystic carcinoma, 8 mucoepidermoid carcinoma, 2 adenocarcinoma, and 10 miscellaneous tumors.
  • In contrast, the mean survival in the selected 62 patients with squamous cancers was 40 months and 5-year survival was 29% (P = 0.01).
  • CONCLUSIONS: Patients with non-squamous cancers of the maxillary sinus present with locally advanced disease.
  • Local tumor progression remains a significant pattern of failure; however, unlike squamous cancers they have a better prognosis.

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16550558.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Li ZJ, Tang PZ, Xu ZG: [Experience of diagnosis and treatment for primary cervical tracheal tumors]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Mar;41(3):208-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Experience of diagnosis and treatment for primary cervical tracheal tumors].
  • OBJECTIVE: To review the experience of diagnosis and treatment of primary cervical tracheal tumor.
  • RESULTS: Thirty four patients had malignant tumors, among which 19 cases were adenoid cystic carcinoma and 10 cases squamous cell carcinoma.
  • 36% respectively for the patients with adenoid cystic carcinoma, 80.00% and 20.
  • 00% respectively for the patients with squamous cell carcinoma.
  • CONCLUSIONS: Most of primary cervical tracheal tumors were malignant, adenoid cystic carcinoma and squamous cell carcinoma were the common malignant cervical tracheal tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / surgery. Tracheal Neoplasms / surgery

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  • (PMID = 16759018.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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38. Qi XP, Lin GB, Zhu YL, Wang JQ, Dai XW, Ma JM, Yan L: [Pseudoangiosarcomatous squamous cell carcinoma of the penis: a case report with clinicopathological and human papilloma virus analyses]. Zhonghua Nan Ke Xue; 2009 Feb;15(2):134-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pseudoangiosarcomatous squamous cell carcinoma of the penis: a case report with clinicopathological and human papilloma virus analyses].
  • OBJECTIVE: To further understand the clinicopathological, ultrastructural and molecular features of penile pseudoangiosarcomatous squamous cell carcinoma (PASCC), and improve its diagnosis and treatment.
  • CT scanning showed no enlarged lymph nodes in the abdomen and pelvis, and X-ray examination revealed no abnormality in the chest.
  • RESULTS: The diagnosis was established by biopsy.
  • Under the light microsope, the tumor was mainly composed of vessel-like lacunar reticularis spindle cells and a few local squamous cancer cells.
  • Careful examination revealed some focal areas with evident transition from squamous nests to the more acantholytic areas extending towards the pseudoangiosarcomatous spaces.
  • Pathogenetically, it appeared to be the variant of acantholytic squamous cell carcinoma.
  • Immunohistochemically, most tumor cells were strongly positive for keratin (AE1/AE3) and focally positive for EMA, with the typical squamous cells focally positive for 34betaE12 and vimentin.
  • CONCLUSION: PASCC is a specific and extremely rare subtype of penile SCC with dramatic similarity to angiosarcoma under the microscope, with poor prognosis.
  • Its diagnosis depends on histopathological, immunohistochemical and ultrastructural studies.
  • Such a presentation underscores the importance of timely consultation, early diagnosis and prompt treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / virology. Papillomaviridae / isolation & purification. Penile Neoplasms / pathology. Penile Neoplasms / virology

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  • (PMID = 19323373.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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39. Farrell T, Chang YL: Basal cell adenocarcinoma of minor salivary glands. Arch Pathol Lab Med; 2007 Oct;131(10):1602-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenocarcinoma of minor salivary glands.
  • Basal cell adenocarcinoma of minor salivary glands is a relatively rare slow-growing tumor with an infiltrating growth pattern.
  • The infiltrating growth pattern and likelihood of vascular and perineural involvement distinguishes basal cell adenocarcinoma from basal cell adenoma.
  • Other diagnostic considerations include adenoid cystic carcinoma and basaloid squamous carcinoma.
  • Basal cell adenocarcinomas show strong immunoreactivity to cytokeratin 7 and variable myoepithelial staining with S100.
  • It is necessary to differentiate basal cell adenocarcinoma from other basaloid cell tumors of the minor salivary glands because of the prognosis and potential differences in treatment, particularly adenoid cystic adenocarcinoma and basaloid squamous carcinoma.
  • Surgical excision with a wide margin to ensure complete removal has been suggested as the primary treatment for basal cell adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Squamous Cell / diagnosis. Combined Modality Therapy. Diagnosis, Differential. Humans

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  • (PMID = 17922602.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Ly V, Gupta S, Desoto F, Cutaia M: Tracheal squamous cell carcinoma treated endoscopically. J Bronchology Interv Pulmonol; 2010 Oct;17(4):353-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tracheal squamous cell carcinoma treated endoscopically.
  • Malignant primary tracheal tumors are extremely rare.
  • The most common malignant primary tracheal tumors are squamous cell carcinoma and adenoid cystic carcinomas.
  • In this brief report, we describe a patient who presented with a primary papillary squamous cell carcinoma in-situ at multiple areas in the trachea with a significant airway obstruction.

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  • (PMID = 23168962.001).
  • [ISSN] 1944-6586
  • [Journal-full-title] Journal of bronchology & interventional pulmonology
  • [ISO-abbreviation] J Bronchology Interv Pulmonol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Bhattacharyya N, Fried MP: Determinants of survival in parotid gland carcinoma: a population-based study. Am J Otolaryngol; 2005 Jan-Feb;26(1):39-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Determinants of survival in parotid gland carcinoma: a population-based study.
  • Subset analysis was conducted for mucoepidermoid carcinoma according to grade.
  • Mean tumor size at diagnosis was 2.7 cm; 38.0% of patients had extraglandular extension of the tumor, 26.8% of patients had positive nodal disease, and 59.4% of patients received radiation therapy.
  • Tumor histology did predict survival, with squamous cell carcinoma and acinar cell carcinoma exhibiting the poorest and best survivals, respectively.
  • [MeSH-major] Adenocarcinoma / mortality. Carcinoma, Squamous Cell / mortality. Parotid Neoplasms / mortality
  • [MeSH-minor] Age Factors. Carcinoma, Acinar Cell / mortality. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Mucoepidermoid / mortality. Female. Humans. Male. Neoplasm Staging. Prognosis. Proportional Hazards Models. Risk Factors. SEER Program. Sex Factors. Survival Analysis. United States / epidemiology

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  • (PMID = 15635580.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Munir N, Bradley PJ: Diagnosis and management of neoplastic lesions of the submandibular triangle. Oral Oncol; 2008 Mar;44(3):251-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and management of neoplastic lesions of the submandibular triangle.
  • Review of submandibular triangle neoplasms (benign and malignant) treated at a tertiary referral centre in the United Kingdom (1986-2004).
  • Forty nine benign and 58 malignant neoplasms of the submandibular triangle were reviewed.
  • Definitive diagnosis was by excision and pathological examination.
  • For malignant lesions (n=58), 48 were primary malignancies and 10 metastatic lesions.
  • The most frequent primary lesions were malignant non-Hodgkin lymphoma (n=22), adenoid cystic carcinoma (n=9) and mucoepidermoid carcinoma (n=9).
  • The mainstay treatment for both benign and malignant lesions was surgical either by extracapsular excision of the gland/lesion or selective levels I, IIa and III neck dissection.
  • There is a relatively high incidence of malignant neoplasms in this region (54%).
  • Malignant tumours have a poor symptomatology that can result in late (often post-operative) diagnosis.
  • The adequacy of primary surgery is crucial and would support the approach of a more radical excision primarily with a selective levels I, IIa and III neck dissection; ensuring a definitive operation for benign lesions, avoiding the risks of tumour spillage associated with a more limited excision; and removing the primary echelon of lymph nodes at risk of metastasis if the pathology in fact turns out to be malignant; without a significantly higher morbidity in comparison with an extracapsular gland/lesion excision.
  • [MeSH-major] Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Child. Female. Humans. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / surgery. Male. Middle Aged. Retrospective Studies. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / surgery. Treatment Outcome

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  • (PMID = 17467329.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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43. Kacerovska D, Szepe P, Vanecek T, Nemcova J, Michal M, Mukensnabl P, Kazakov DV: Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations. Am J Dermatopathol; 2008 Oct;30(5):472-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations.
  • The authors report a case of basaloid carcinoma involving the anus and rectum of a 57-year-old woman.
  • Microscopically, the tumor showed unusual morphologic features strongly resembling a spiradenocylindroma because it consisted, in most parts, of basaloid cell nodules arranged in a jigsaw-puzzle fashion containing or surrounded by eosinophilic basal membrane material; in addition, there were intratumoral lymphocytes.
  • The overlying squamous epithelium manifested dysplastic changes compatible with in situ squamous carcinoma that gradually became invasive and blended with basaloid cell islands; additionally, there were koilocytes in the squamous epithelium.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Human papillomavirus 16 / pathogenicity. Rectal Neoplasms / pathology. Skin Neoplasms / pathology. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Middle Aged. Mutation / genetics

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  • (PMID = 18806492.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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44. Yu Y, Zhang R, Dai C: [The study on the en bloc resection of the external auditory canal to treat external auditory canal carcinoma in the early stage]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Apr;23(7):313-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The study on the en bloc resection of the external auditory canal to treat external auditory canal carcinoma in the early stage].
  • To improve early diagnosis and the effective surgical management of external auditory canal carcinoma.
  • METHOD: Twelve cases of the early stage external auditory canal carcinoma were reviewed retrospectively.
  • Postoperative pathological diagnosis revealed that 6 cases with adenoid cystic carcinomas, 5 cases of squamous cell carcinomas, 1 case of cerumenal adenocarcinoma.
  • Five cases of squamous cell carcinomas, 1 case of cerumenal adenocarcinoma and 3 cases of adenoid cystic carcinomas received radiotherapy postoperatively.
  • All patients were alive free of carcinoma during the follow-up.
  • CONCLUSION: Timely and accurate biopsy is the key point to diagnose the early stage external auditory canal carcinoma.
  • The complete resection with safety margin of external auditory canal carcinoma can improve the effect of surgery.
  • [MeSH-major] Carcinoma / surgery. Ear Neoplasms / surgery. Ear, External / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 19670611.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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45. Wen SL, Zhou X, Hu HH, Peng ZZ: [Clinical characteristics of 8 cases of primary tracheal tumors]. Zhonghua Jie He He Hu Xi Za Zhi; 2009 Sep;32(9):660-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To explore the clinical characteristics of primary tracheal tumors and therefore to improve the diagnosis and treatment.
  • Examination by fiberoptic bronchoscopy confirmed the diagnosis of tracheal tumor in all the cases.
  • One case with benign neurinoma and 2 cases with adenoid cystic carcinomas had a long-term postoperative remission.
  • Two cases of squamous cell carcinoma with severe tracheal stenosis got rapid symptom remission after intervention of tracheal stent by fiberoptic bronchoscopy and argon plasma coagulation.
  • One patient with adenoid cystic carcinoma refused any treatment.
  • One patient with squamous cell carcinoma lost follow-up after surgery.
  • Early diagnosis can be made by chest CT and fiberoptic bronchoscopy.
  • Benign tracheal tumors can be resected, and for some low-grade malignant tumors surgical resection and postoperative radiotherapy can improve long term survival.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / therapy. Tracheal Neoplasms / diagnosis. Tracheal Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Adult. Aged. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 20079278.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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46. Meer S, Altini M: CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology; 2007 Jul;51(1):26-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumours included pleomorphic adenoma (n = 24), myoepithelioma (n = 9), papillary cystadenoma (n = 3), oncocytoma (n = 2), adenoid cystic carcinoma (n = 22), mucoepidermoid carcinoma (n = 21), polymorphous low-grade adenocarcinoma (n = 21), carcinoma ex-pleomorphic adenoma (n = 11), acinic cell carcinoma (n = 17), epimyoepithelial carcinoma (n = 7), oncocytic carcinoma (n = 3), hyalinizing clear cell carcinoma (n = 1), papillary cystadenocarcinoma (n = 1), salivary duct carcinoma (n = 3), adenocarcinoma (not otherwise specified) (n = 4) and squamous carcinoma (n = 4).
  • Squamous carcinoma showed negative CK7/20 immunoexpression.
  • CONCLUSIONS: Although the CK7/20 immunoprofile is not useful in distinguishing the various types of salivary gland neoplasms or between benign and malignant salivary gland tumours, it may facilitate differentiation of primary salivary gland neoplasia from metastatic tumours and squamous carcinoma, and the diagnosis of metastatic salivary gland tumours.
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Carcinoma, Acinar Cell / diagnosis. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Diagnosis, Differential. Gene Expression Regulation, Neoplastic. Humans. Salivary Glands / metabolism. Salivary Glands / pathology

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  • (PMID = 17593078.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
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47. Boo H, Hogg JP: Nasal cavity neoplasms: a pictorial review. Curr Probl Diagn Radiol; 2010 Mar-Apr;39(2):54-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Examples include squamous cell cancer, adenoid cystic cancer, esthesioneuroblastoma, inverted papilloma, juvenile nasal angiofibroma, melanoma, lymphoma, sarcoma, and benign nasal histiocytoma.
  • [MeSH-major] Nasal Cavity. Nose Neoplasms / diagnosis
  • [MeSH-minor] Angiofibroma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Squamous Cell / diagnosis. Chondrosarcoma / diagnosis. Diagnosis, Differential. Esthesioneuroblastoma, Olfactory / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Humans. Magnetic Resonance Imaging. Melanoma / diagnosis. Papilloma, Inverted / diagnosis. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20113866.001).
  • [ISSN] 1535-6302
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Buchmann L, Larsen C, Pollack A, Tawfik O, Sykes K, Hoover LA: Endoscopic techniques in resection of anterior skull base/paranasal sinus malignancies. Laryngoscope; 2006 Oct;116(10):1749-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The most common diagnosis was squamous cell carcinoma occurring in 33% of the cases.
  • The remaining pathologies included esthesioneuroblastoma (23%), adenoid cystic carcinoma (15%), melanoma (3%), sinonasal undifferentiated carcinoma (3%), lymphoma (5%), nasopharyngeal carcinoma (4%), and other tumor types (14%).
  • [MeSH-minor] Carcinoma / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / surgery. Disease-Free Survival. Esthesioneuroblastoma, Olfactory / surgery. Esthetics. Female. Follow-Up Studies. Humans. Lymphoma / surgery. Male. Maxilla / surgery. Melanoma / surgery. Middle Aged. Nasopharyngeal Neoplasms / surgery. Neoadjuvant Therapy. Neoplasm Recurrence, Local / therapy. Retrospective Studies. Survival Rate

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  • (PMID = 17003718.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Webb BD, Walsh GL, Roberts DB, Sturgis EM: Primary tracheal malignant neoplasms: the University of Texas MD Anderson Cancer Center experience. J Am Coll Surg; 2006 Feb;202(2):237-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary tracheal malignant neoplasms: the University of Texas MD Anderson Cancer Center experience.
  • BACKGROUND: Primary malignant neoplasms of the trachea are very rare and data relating to them are limited.
  • STUDY DESIGN: Retrospective chart review was conducted for all patients found to have a pathologic diagnosis of primary tracheal malignancy.
  • Among these, 34 (45.9%) were squamous cell carcinomas, 19 (25.7%) were adenoid cystic carcinomas, and 21 (28.4%) were of other histologic types.
  • Most patients (77.3%) were former or current smokers, particularly those with squamous cell carcinoma (93.3%).
  • Patients who had adenoid cystic carcinoma and those with cervical primaries had better rates of disease-specific and overall survival than others (p = 0.036 and 0.006 for the former patient group and p = 0.006 and 0.030 for the latter patient group).
  • Although squamous cell carcinoma was the most common pathology in smokers, adenoid cystic carcinoma was more prevalent among nonsmokers.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / pathology. Tracheal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Comorbidity. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Smoking / epidemiology. Survival Analysis

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  • (PMID = 16427548.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. López-Varela E, Oliva E, McIntyre JF, Fuller AF Jr: Primary treatment of Bartholin's gland carcinoma with radiation and chemoradiation: a report on ten consecutive cases. Int J Gynecol Cancer; 2007 May-Jun;17(3):661-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary treatment of Bartholin's gland carcinoma with radiation and chemoradiation: a report on ten consecutive cases.
  • We reviewed our experience with primary radiation therapy for Bartholin's gland carcinoma (BGC) as an alternative to traditional surgical treatment.
  • The median age at diagnosis was 63.5 years.
  • There were five squamous cell carcinomas, two adenoid cystic carcinomas, two mucinous adenocarcinomas, and one small-cell carcinoma.
  • [MeSH-major] Bartholin's Glands. Carcinoma / drug therapy. Carcinoma / radiotherapy. Vulvar Neoplasms / drug therapy. Vulvar Neoplasms / radiotherapy

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  • (PMID = 17504379.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article
  • [Publication-country] United States
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51. Liu FY, Liu XY, Wang Z, Liu Y: [The long-term outcome and prognostic analysis of surgically treated patients with trachea tumors]. Zhonghua Wai Ke Za Zhi; 2009 Jul 15;47(14):1055-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The histological examination of resected lesions revealed squamous cell carcinoma in 19 cases, adenoid cystic carcinoma in 8 cases, adenocarcinoma in 2 cases, carcinoid in 2 cases, leiomyosarcoma in 1 case and adenoma in 1 case.
  • CONCLUSIONS: Squamous cell carcinoma adenoid cystic carcinoma are the most common in trachea tumors.

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  • (PMID = 19781267.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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52. Lü BJ, Zhu J, Gao L, Xie L, Xu JY, Lai MD: [Diagnostic accuracy and pitfalls in fine needle aspiration cytology of salivary glands: a study of 113 cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):706-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The FNAC diagnostic failure (2); non-neoplastic lesions (12); benign neoplasm (82) and malignant neoplasm (17).
  • Cytologically, the distinction between cellular pleomorphic adenoma, adenoid cystic carcinoma and basal cell adenoma could be difficult due to their overlapping morphologic features.
  • The cytologic patterns of primary lymphoepithelial carcinoma of the parotid were indistinguishable from those of metastatic nasopharyngeal undifferentiated carcinoma.
  • The three inaccurately diagnosed cases of FNAC are, as follows: reactive lymphoid hyperplasia of lymph node mistaken as non-Hodgkin lymphoma, mucoepidermoid carcinoma diagnosed as "scanty atypical cells present" and primary lymphoepithelial carcinoma mistaken as benign lymphoepithelial lesion.
  • On the basis of FNAC, 97.4% (110 /113) were correctly depicted as benign (95/96; 99.0%) or malignant (15/17; 88.2%).
  • Furthermore, 90.3% (102 /113) (specificity = 91.9%; 102/111) were accurately diagnosed, including 91.7% (88/96) benign lesions (specificity = 92.6% ; 88/95) and 82.4% (14/17) malignant tumors (specificity = 87.5%; 14/16).
  • CONCLUSIONS: FNAC is reliable in distinguishing benign and malignant salivary gland lesions.
  • A specific cytologic diagnosis is often possible.
  • On the other hand, due to the pitfalls in cytologic diagnosis of certain salivary gland tumors, tissue biopsy for histologic examination may be necessary.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Carcinoma, Squamous Cell / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma / pathology. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Biopsy, Fine-Needle. Carcinoma, Adenoid Cystic / pathology. Child. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Male. Middle Aged. Parotid Neoplasms / pathology. Retrospective Studies. Submandibular Gland Neoplasms / pathology

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  • (PMID = 16536312.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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53. Serrano MF, El-Mofty SK, Gnepp DR, Lewis JS Jr: Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck. Hum Pathol; 2008 Apr;39(4):591-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck.
  • High-grade neuroendocrine carcinomas of the head and neck overlap significantly in morphology with both basaloid squamous and solid-type adenoid cystic carcinomas.
  • Basaloid squamous and adenoid cystic carcinomas are aggressive variants of their respective tumor types which both have nests of basaloid tumor cells with round nuclei, little cytoplasm, and inconspicuous nucleoli.
  • We performed high molecular weight cytokeratin (CK) and p63 immunohistochemistry on 19 neuroendocrine carcinomas, 18 basaloid squamous carcinomas, and 11 solid-type adenoid cystic carcinomas.
  • All basaloid squamous and adenoid cystic carcinomas were positive for CK 5/6 and 34betaE12.
  • Staining was focal in the neuroendocrine cases when positive, whereas almost all basaloid squamous and adenoid cystic carcinomas showed strong staining.
  • Basaloid squamous carcinomas were diffusely positive, neuroendocrine carcinomas were diffusely positive, but with weak staining, and adenoid cystic carcinomas showed a distinct pattern with staining at the periphery of the cell nests only.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basosquamous / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Head and Neck Neoplasms / diagnosis. Keratins / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-5 / analysis. Keratin-6 / analysis. Male. Membrane Proteins / analysis. Middle Aged. Molecular Weight


54. Chang CH, Shu MT, Lee JC, Leu YS, Chen YC, Lee KS: Treatments and outcomes of malignant tumors of external auditory canal. Am J Otolaryngol; 2009 Jan-Feb;30(1):44-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatments and outcomes of malignant tumors of external auditory canal.
  • The purpose of this study is to evaluate the treatment modalities and outcomes for malignant tumors of EAC at our institute, comparing with other studies.
  • RESULTS: Ten patients had squamous cell carcinoma and 2 had adenoid cystic carcinoma (ACC).
  • Only one patient with complete resection had recurrence and the histologic diagnosis of this particular patient was ACC.
  • [MeSH-major] Ear Canal / pathology. Ear Neoplasms / mortality. Ear Neoplasms / therapy. Neoplasm Recurrence, Local / mortality
  • [MeSH-minor] Adult. Aged. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / therapy. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Cohort Studies. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Otologic Surgical Procedures / methods. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Taiwan

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  • (PMID = 19027512.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Driemel O, Müller-Richter UD, Hakim SG, Bauer R, Berndt A, Kleinheinz J, Reichert TE, Kosmehl H: Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma. Head Face Med; 2008;4:17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma.
  • BACKGROUND: acantholytic squamous cell carcinomas (ASCC) and intraoral angiosarcoma share similar histopathological features.
  • METHODS: Four oral acantholytic squamous cell carcinomas and one intraoral angiosarcoma are used to compare the eruptive intraoral growth-pattern, age-peak, unfavourable prognosis and slit-like intratumorous spaces in common histological staining as identical clinical and histopathological features.
  • Loss of cell-cell-adhesion, monitored by loss of E-cadherin and beta-catenin membrane-staining, are indetified as reasons for massive expression of invasion-factor ln-5 in ASCC and considered responsible for unfavourable prognosis of ASCC.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Hemangiosarcoma / pathology. Mouth / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Acantholysis. Aged. Biopsy, Needle. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged


56. Romão RL, de Barros F, Maksoud Filho JG, Gonçalves ME, Cardoso S, Tannuri AC, Tannuri U: Malignant tumor of the trachea in children: diagnostic pitfalls and surgical management. J Pediatr Surg; 2009 Nov;44(11):e1-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant tumor of the trachea in children: diagnostic pitfalls and surgical management.
  • Primary tracheal malignant neoplasms are very rare.
  • Histologically, squamous cell and adenoid cystic carcinomas are the most common types of malignant primary tracheal tumors when all age groups are studied.
  • In the past 5 years, we treated 2 children with tracheal mucoepidermoid carcinoma.
  • Herein we report both cases and review the literature on the subject with particular emphasis on diagnosis and surgical management.
  • [MeSH-major] Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / surgery. Reconstructive Surgical Procedures / methods. Thoracotomy / methods. Tracheal Neoplasms / diagnosis. Tracheal Neoplasms / surgery

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  • (PMID = 19944203.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Suzuki K, Nishioka T, Homma A, Tsuchiya K, Yasuda M, Aoyama H, Onimaru R, Tamaki N, Shirato H: Value of fluorodeoxyglucose positron emission tomography before radiotherapy for head and neck cancer: does the standardized uptake value predict treatment outcome? Jpn J Radiol; 2009 Jul;27(6):237-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Biopsy was performed in all patients to determine the histological diagnosis.
  • Altogether, 14 biopsy specimens were available for mitotic and apoptotic cell counts.
  • For 41 patients with squamous cell carcinoma or undifferentiated carcinoma, SUVmax did not reflect the histological grade.
  • [MeSH-major] Adenoma, Pleomorphic / radionuclide imaging. Carcinoma, Adenoid Cystic / radionuclide imaging. Carcinoma, Squamous Cell / radionuclide imaging. Fluorodeoxyglucose F18. Head and Neck Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Apoptosis. Humans. Male. Middle Aged. Mitosis. Neoplasm Staging. Pharynx / pathology. Pharynx / radionuclide imaging. Predictive Value of Tests. Radiopharmaceuticals. Young Adult

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  • (PMID = 19626409.001).
  • [ISSN] 1867-1071
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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58. Itoh K, Shiozawa T, Ohira S, Shiohara S, Konishi I: Correlation between MRI and histopathologic findings in stage I cervical carcinomas: influence of stromal desmoplastic reaction. Int J Gynecol Cancer; 2006 Mar-Apr;16(2):610-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although the effectiveness of magnetic resonance imaging (MRI) in depicting cervical carcinoma has been reported, whether MRI can detect early-stage or stage IB "occult"-type cervical carcinoma remained undetermined.
  • We examined the correlation between MRI and pathologic findings in 38 stage I (IB 28 cases, IA 10 cases) cervical carcinoma patients, with special reference to the influence of desmoplastic stromal reaction around the tumor.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Squamous Cell / diagnosis. Magnetic Resonance Imaging. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Female. Humans. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Predictive Value of Tests. Preoperative Care. Retrospective Studies. Risk Factors. Sensitivity and Specificity

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  • (PMID = 16681734.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Honings J, van Dijck JA, Verhagen AF, van der Heijden HF, Marres HA: Incidence and treatment of tracheal cancer: a nationwide study in the Netherlands. Ann Surg Oncol; 2007 Feb;14(2):968-76

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Data on histological type, age at time of diagnosis, treatment, and survival were analyzed retrospectively.
  • In 52.9%, the histological type was squamous cell carcinoma and in only 7.1% adenoid cystic carcinoma (ACC).
  • Mean age at time of diagnosis was 64.3 years.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Tracheal Neoplasms / epidemiology

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  • (PMID = 17139460.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Honings J, Gaissert HA, van der Heijden HF, Verhagen AF, Kaanders JH, Marres HA: Clinical aspects and treatment of primary tracheal malignancies. Acta Otolaryngol; 2010 Jul;130(7):763-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Primary tracheal tumors pose a diagnostic and therapeutic challenge for the physician when confronted with this mostly malignant tumor.
  • Diagnosis is often delayed for months or years due to its aspecific and asthma-mimicking symptoms.
  • The available literature on the diagnosis and management of this group of tumors is reviewed to summarize the available knowledge about these uncommon tumors.
  • [MeSH-major] Tracheal Neoplasms / diagnosis. Tracheal Neoplasms / therapy
  • [MeSH-minor] Airway Obstruction / etiology. Airway Obstruction / therapy. Algorithms. Bronchoscopy. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / therapy. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / therapy. Cough / etiology. Diagnostic Imaging. Dyspnea / etiology. Hemoptysis / etiology. Humans. Neoplasm Staging. Respiratory Function Tests. Respiratory Sounds / etiology. Survival Rate. Trachea / surgery

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  • (PMID = 20569185.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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61. Chang SM, Xing RD, Zhang FM, Duan YQ: Serum soluble CD44v6 levels in patients with oral and maxillofacial malignancy. Oral Dis; 2009 Nov;15(8):570-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To determine the levels of serum sCD44v6 in patients with oral cancer and evaluate the value of serum sCD44v6 in adjuvant diagnosis, staging and monitoring treatment response in these patients.
  • One week after treatment, venous blood was collected once again in 60 patients with oral and maxillofacial squamous cell carcinoma (OSCC).
  • The levels of serum sCD44v6 in patients with OSCC and salivary carcinoma showed no difference with those in control group (P > 0.05).
  • CONCLUSION: The possible roles of CD44v6 in the diagnosis of oral and maxillofacial malignancy deserve further elucidation and evaluation.
  • [MeSH-major] Antigens, CD44 / blood. Biomarkers, Tumor / blood. Carcinoma, Squamous Cell / blood. Head and Neck Neoplasms / blood. Mouth Neoplasms / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / blood. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / blood. Carcinoma, Mucoepidermoid / drug therapy. Carcinoma, Mucoepidermoid / surgery. Case-Control Studies. Female. Humans. Male. Middle Aged. Neoplasm Staging. Reference Values. Salivary Gland Neoplasms / blood. Salivary Gland Neoplasms / drug therapy. Salivary Gland Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19563418.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / CD44v6 antigen
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62. Vaidhyanath R, Kirke R, Brown L, Sampath R: Lacrimal fossa lesions: pictorial review of CT and MRI features. Orbit; 2008;27(6):410-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Eye Neoplasms / diagnosis. Lacrimal Apparatus Diseases / diagnosis. Magnetic Resonance Imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Squamous Cell / diagnosis. Dacryocystitis / diagnosis. Dermoid Cyst / diagnosis. Granulomatosis with Polyangiitis / diagnosis. Humans. Lymphoproliferative Disorders / diagnosis. Sarcoidosis / diagnosis. Sjogren's Syndrome / diagnosis

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  • (PMID = 19085295.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 27
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63. Koffi-Aka V, Tano N, Ngouan J, Ehouo F: [Management of cancers of nasal cavities and paranasal sinuses in the ENT Unit at CHU de Treichville (Abidjan)]. Mali Med; 2008;23(4):47-50
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  • [Title] [Management of cancers of nasal cavities and paranasal sinuses in the ENT Unit at CHU de Treichville (Abidjan)].
  • [Transliterated title] Prise en Charge des Cancers Naso-Sinusiens dans le Service D'Orl du CHU de Treichville (Abidjan).
  • The diagnosis was late in the majority of the cases (T > 2: n=5).
  • [MeSH-major] Carcinoma / surgery. Hospital Departments / statistics & numerical data. Hospitals, University / statistics & numerical data. Nasal Cavity. Nose Neoplasms / surgery. Otolaryngology / statistics & numerical data. Paranasal Sinus Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / surgery. Cote d'Ivoire / epidemiology. Delayed Diagnosis. Female. Humans. Lymph Node Excision. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19617175.001).
  • [ISSN] 1993-0836
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mali
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64. Kupferman ME, de la Garza GO, Santillan AA, Williams MD, Varghese BT, Huh W, Roberts D, Weber RS: Outcomes of pediatric patients with malignancies of the major salivary glands. Ann Surg Oncol; 2010 Dec;17(12):3301-7
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  • Patients less than 19 years of age with a diagnosis of a major salivary gland malignancy were identified at the M. D.
  • The majority of tumors arose in the parotid gland (83%), and the most common pathology was mucoepidermoid carcinoma (46%).
  • Lymphatic metastasis was identified in 37% of patients, nearly all with mucoepidermoid carcinoma.
  • [MeSH-major] Adenocarcinoma / therapy. Carcinoma, Adenoid Cystic / therapy. Carcinoma, Mucoepidermoid / therapy. Carcinoma, Squamous Cell / therapy. Salivary Gland Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Neoplasm Staging. Radiotherapy Dosage. Retrospective Studies. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 20585877.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Carrillo JF, Celis MA, Ramirez-Ortega M, Rivas B, Ochoa FJ: Osteoplastic maxillotomy for treatment of neoplasms of the nasopharynx and infratemporal fossa. Ann Otol Rhinol Laryngol; 2005 Jan;114(1 Pt 1):58-64

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ten patients underwent osteoplastic maxillotomy, 3 of whom had a diagnosis of malignancy, and 7 of whom had nasopharyngeal angiofibromas (NPAs).
  • Resection of malignant lesions with good results is feasible.
  • [MeSH-minor] Adolescent. Adult. Aged. Angiofibroma / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / surgery. Craniotomy. Esthetics. Female. Hemangiopericytoma / surgery. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Quality of Life. Treatment Outcome. Zygoma / surgery

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  • (PMID = 15697164.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Combs SE, Konkel S, Schulz-Ertner D, Münter MW, Debus J, Huber PE, Thilmann C: Intensity modulated radiotherapy (IMRT) in patients with carcinomas of the paranasal sinuses: clinical benefit for complex shaped target volumes. Radiat Oncol; 2006;1:23

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  • Histological classification included squamous cell carcinoma in 6, adenocarcinoma in 8, adenoidcystic carcinoma in 20 and melanoma in 8 patients, respectively.
  • Six patients had been treated with RT during initial therapy after primary diagnosis, and IMRT was performed for the treatment of tumor progression as re-irradiation.
  • [MeSH-major] Carcinoma / radiotherapy. Paranasal Sinus Neoplasms / radiotherapy. Paranasal Sinuses / radiation effects. Radiotherapy, Intensity-Modulated / methods
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / radiotherapy. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / radiotherapy. Female. Humans. Male. Melanoma / radiotherapy. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted / methods. Treatment Outcome

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  • (PMID = 16859556.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1557519
  • [General-notes] NLM/ Original DateCompleted: 20070720
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67. Bandyopadhyay A, Das TK, Raha K, Hati GC, Mitra PK, Dasgupta A: A study of fine needle aspiration cytology of salivary gland lesions with histopathological corroboration. J Indian Med Assoc; 2005 Jun;103(6):312-4, 316
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All smears were evaluated according to cell size, amount of cytoplasm, cytologic atypia and presence of lymphocytes. (a) Variable cytologic appearances of pleomorphic salivary adenoma were observed. (b) Cellular pleomorphic adenoma and adenoid cystic carcinoma showed basaloid cell features. (c) Tumours with intermediate size cells and bland cytology included low grade muco-epidermoid carcinoma and cystic lesions. (d) Warthin's tumour, oncocytoma, salivary duct carcinoma and high grade muco-epidermoid carcinoma revealed large cells and abundant cytoplasm with or without atypia.
  • A major diagnostic categories were inflammatory lesions (n = 7 5), cystic lesions (n = 9), benign tumours (n = 81), malignant neoplasms (n = 1 8) and normal acinar pattern (n = 2).
  • Malignant tumours included muco-epidermoid carcinoma (n = 5), adenoid cystic carcinoma (n = 3), acinic cell carcinoma (n = 2), adenocarcinoma (n= 2), squamous cell carcinoma (n = 1), undifferentiated carcinoma (n= 4) and malignant lymphoma (n = 1).
  • Histopathological correlation was possible in 40% of benign and 80% of malignant neoplasms.
  • So it can be concluded that fine needle aspiration cytology can play important role in early diagnosis and subsequent therapeutic planning of salivary gland lesions.

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  • (PMID = 16225156.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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68. Akiyama F, Horii R: Therapeutic strategies for breast cancer based on histological type. Breast Cancer; 2009;16(3):168-72
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is generally accepted that the histological types of breast cancer are clinically significant because they serve as prognosticators and as the common language for improving the accuracy of clinical diagnosis.
  • It is necessary to diagnose breast cancer at the level of not only histological findings by needle biopsy, but also the histologic type based on diagnostic imaging and cytological diagnosis.
  • Preoperative drug therapy can be planned by making a histological diagnosis based on needle biopsy findings.
  • Preoperative drug therapy is not indicated for noninvasive carcinoma and papillotubular carcinoma (invasive carcinoma with predominant intraductal components).
  • While complete loss of interstitial infiltration can be expected with solid-tubular carcinoma, it cannot be expected with other histological types, such as invasive lobular carcinoma, adenoid cystic carcinoma, or metaplastic carcinoma (squamous-cell carcinoma and spindle-cell carcinoma).
  • On therapeutic response assessment, the clinical and pathological findings generally match for solid-tubular carcinoma but not for scirrhous carcinoma and invasive lobular carcinoma.
  • With mucinous carcinoma, mucus accumulation can remain, even though most cancer cells disappear; as a result, assessment based on tumor diameter changes is difficult.
  • Histological diagnosis is also significant from the viewpoint of drug sensitivity, and it is important to maintain the accuracy of histological diagnosis.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Breast Neoplasms / drug therapy. Carcinoma / drug therapy

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  • (PMID = 19479319.001).
  • [ISSN] 1880-4233
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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69. Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E: Perineural tumor spread. Neuroimaging Clin N Am; 2008 May;18(2):413-29, xi
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  • PNS is more frequently associated with carcinoma arising from minor or major salivary glands (more often adenoid cystic carcinoma), mucosal or cutaneous squamous cell carcinoma, basal cell carcinoma, melanoma, lymphoma, and sarcoma.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Cranial Nerve Neoplasms / secondary. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / secondary
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 18466839.001).
  • [ISSN] 1052-5149
  • [Journal-full-title] Neuroimaging clinics of North America
  • [ISO-abbreviation] Neuroimaging Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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70. Ide F, Mishima K, Saito I, Kusama K: Diagnostically challenging epithelial odontogenic tumors: a selective review of 7 jawbone lesions. Head Neck Pathol; 2009 Mar;3(1):18-26

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The other globulomaxillary lesion was managed under the erroneous diagnosis of adenomatoid odontogenic tumor and recurred 4 times over an 11-year period.
  • This tumor was found in retrospect to be consistent with an adenoid ameloblastoma with dentinoid.
  • The diagnosis of cystic squamous odontogenic tumor (SOT) occurring as a radicular lesion of an impacted lower third molar was one of exclusion.
  • Of two unsuspected keratocystic odontogenic tumors, one depicted deceptive features of pericoronitis, while the other case has long been in our files with the diagnosis of globulomaxillary SOT.
  • Two cases of primary intraosseous squamous cell carcinoma appeared benign clinically and exhibited unexpected findings; an impacted third molar began to erupt in association with the growth of carcinoma and another periradicular carcinoma showed dentinoid formation.
  • [MeSH-major] Jaw Neoplasms / diagnosis. Odontogenic Tumors / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnostic Errors. Female. Humans. Male. Middle Aged. Odontogenic Cysts / diagnosis. Periodontal Cyst / diagnosis. Retrospective Studies

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  • (PMID = 20596984.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
  • [Other-IDs] NLM/ PMC2807539
  • [Keywords] NOTNLM ; Clinicopathologic correlation / Diagnostic pitfall / Epithelial odontogenic tumor / Jawbone
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71. Das S, Kirsch CF: Imaging of lumps and bumps in the nose: a review of sinonasal tumours. Cancer Imaging; 2005;5:167-77

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although sinus tumours are rare, they portend a poor prognosis, often due to advanced disease at diagnosis.
  • Malignant neoplasms reviewed include squamous cell carcinoma, the minor salivary gland tumour, adenoid cystic carcinoma, adenocarcinoma, melanoma, lymphoma, and olfactory neuroblastoma (esthesioneuroblastoma).
  • [MeSH-major] Paranasal Sinus Neoplasms / diagnosis

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  • [Copyright] International Cancer Imaging Society.
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  • (PMID = 16361146.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 73
  • [Other-IDs] NLM/ PMC1665243
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72. Zhang S, Bao R, Bagby J, Abreo F: Fine needle aspiration of salivary glands: 5-year experience from a single academic center. Acta Cytol; 2009 Jul-Aug;53(4):375-82
MedlinePlus Health Information. consumer health - Salivary Gland Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There were 5 false negatives: 2 adenoid cystic carcinomas, 1 acinic cell carcinoma, 1 polymorphous low grade adenocarcinoma and 1 metastatic basaloid squamous cell carcinoma.
  • The only false positive was a pleomorphic adenoma misdiagnosed as adenoid cystic carcinoma.
  • The overall accuracy in distinguishing benign from malignant lesions was 79.1%, and the sensitivity for salivary neoplasia was 89.4%.
  • CONCLUSION: Our results are consistent with the literature that salivary gland FNA has good sensitivity, specificity and accuracy in the diagnosis of salivary neoplasms.

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  • (PMID = 19697720.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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73. Park CM, Goo JM, Lee HJ, Kim MA, Lee CH, Kang MJ: Tumors in the tracheobronchial tree: CT and FDG PET features. Radiographics; 2009 Jan-Feb;29(1):55-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A variety of tumors, including primary malignant tumors, secondary malignant tumors, and benign tumors, can occur in the tracheobronchial tree.
  • Primary malignant tumors commonly originate from the surface epithelium or the salivary glands, whereas most benign tumors arise from the mesenchymal tissue.
  • At computed tomography (CT), primary malignant tumors manifest as a polypoid lesion, a focal sessile lesion, eccentric narrowing of the airway lumen, or circumferential wall thickening.
  • At fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET), most squamous cell carcinomas show high uptake, whereas adenoid cystic carcinoma and mucoepidermoid carcinoma show variable uptake depending on the grade of differentiation.
  • Carcinoid tumors commonly show intense enhancement at contrast material-enhanced CT, which can be helpful in making the diagnosis, and usually have lower uptake at FDG PET than would be expected for a malignant tumor.
  • Secondary malignant tumors occur as a result of either hematogenous metastasis or direct invasion by a malignancy from an adjacent structure.
  • Their CT manifestations are similar to those of primary malignant tumors, with uptake at FDG PET depending primarily on the metabolic activity and degree of differentiation of the primary tumor.
  • At FDG PET, benign tumors usually show little or no uptake and can be differentiated from malignant tumors.
  • Knowledge of the characteristic CT and FDG PET findings of tracheobronchial tumors can aid in diagnosis and treatment planning.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Fluorodeoxyglucose F18. Image Enhancement / methods. Subtraction Technique. Tomography, X-Ray Computed / methods. Tracheal Neoplasms / diagnosis

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  • [Copyright] (c) RSNA, 2009.
  • (PMID = 19168836.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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74. Soysal HG: Orbital exenteration: a 10-year experience of a general oncology hospital. Orbit; 2010 Jun;29(3):135-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The age, sex, the location of tumour, the duration of symptoms, histopathological diagnosis, and previous recurrences were noted.
  • Seven different types of histopathology were encountered: squamous cell carcinoma (31 cases), basal cell carcinoma (26 cases), malignant melanoma (5 cases), sebaceous cell carcinoma (2 cases), rhabdomyosarcoma (2 cases), mucoepidermoid carcinoma (1 case) and adenoid cystic carcinoma (1 case).
  • [MeSH-major] Neoplasm Invasiveness / pathology. Orbit Evisceration / methods
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Cohort Studies. Conjunctival Neoplasms / pathology. Conjunctival Neoplasms / surgery. Eye Neoplasms / pathology. Eye Neoplasms / surgery. Eyelid Neoplasms / pathology. Eyelid Neoplasms / surgery. Female. Hospitals, General. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Oncology Service, Hospital. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery. Prognosis. Retrospective Studies. Risk Assessment. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 20497078.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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75. Valente G, Mamo C, Bena A, Prudente E, Cavaliere C, Kerim S, Nicotra G, Comino A, Palestro G, Isidoro C, Beatrice F: Prognostic significance of microvessel density and vascular endothelial growth factor expression in sinonasal carcinomas. Hum Pathol; 2006 Apr;37(4):391-400
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • The prognostic significance of microvessel density and proliferative activity of the neoplastic cells, evaluated respectively by CD31 and Ki-67 positivity, and immunohistochemical expression of vascular endothelial growth factor (VEGF) was retrospectively investigated in 105 cases of sinonasal carcinoma (80 surgical specimens and 25 biopsies).
  • The most represented histologic types were intestinal-type adenocarcinoma found in 36 patients (34.3%), squamous cell carcinoma (SCC) in 34 (32.4%), mucinous adenocarcinoma (mainly made up of signet-ring cell patterns) in 15 (14.3%), and adenoid cystic carcinoma in 7 (6.7%).
  • Microvessel density values (in vessels per square millimeter), VEGF, and Ki-67 were not dependent on histologic type but were rather correlated to the histologic grading in SCC.
  • Most of the patients (81.5%) were at an advanced stage (T3-T4) at diagnosis.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Ki-67 Antigen / metabolism. Male. Microcirculation / pathology. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies

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  • (PMID = 16564912.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Vascular Endothelial Growth Factor A
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76. Ben Simon GJ, Schwarcz RM, Douglas R, Fiaschetti D, McCann JD, Goldberg RA: Orbital exenteration: one size does not fit all. Am J Ophthalmol; 2005 Jan;139(1):11-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diagnosis included orbital, ocular, and adnexal malignancies, with squamous and basal cell carcinoma being the most common.
  • CONCLUSIONS: Clinical indications for orbital exenteration remain similar over the last four decades with a higher prevalence of squamous cell carcinoma in our institute.
  • Orbital exenteration is considered curative in cases of basal or squamous cell carcinoma but not in cases of malignant infiltrative processes such as adenoid cystic carcinoma of the lacrimal gland.

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  • [CommentIn] Am J Ophthalmol. 2005 Jan;139(1):152-3 [15652840.001]
  • (PMID = 15652823.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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77. Montalban A, Liétin B, Louvrier C, Russier M, Kemeny JL, Mom T, Gilain L: Malignant lacrimal sac tumors. Eur Ann Otorhinolaryngol Head Neck Dis; 2010 Nov;127(5):165-72
MedlinePlus Health Information. consumer health - Eye Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant lacrimal sac tumors.
  • Overall, 55% of lacrimal sac tumors are malignant.
  • Mortality rates for malignant tumors depend on tumor stage and type, with a mean rate of 38%.
  • PATIENTS AND METHODS: A 15-year retrospective review of all malignant lacrimal sac tumor patients was completed in our department.
  • Seven patients were found to have malignant sac tumors.
  • The histological types were as follows: squamous cell carcinoma (n=5), one case of adenoid cystic carcinoma, and one case of malignant lymphoma.
  • CONCLUSIONS: Malignant epithelial lacrimal sac tumors are rare cancers with significant recurrence rates.
  • Correct diagnosis and appropriate therapy require a multidisciplinary management approach.
  • Treatment of these malignant epithelial tumors is first and foremost complete surgical removal with wide excision.

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21036121.001).
  • [ISSN] 1879-730X
  • [Journal-full-title] European annals of otorhinolaryngology, head and neck diseases
  • [ISO-abbreviation] Eur Ann Otorhinolaryngol Head Neck Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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78. Kuraoka K, Takehara K, Oshita S, Saito A, Taniyama K: Acantholytic squamous cell carcinoma of the uterine cervix. Pathol Int; 2010 Mar;60(3):245-6
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acantholytic squamous cell carcinoma of the uterine cervix.
  • [MeSH-major] Acantholysis / pathology. Carcinoma, Squamous Cell / pathology. Uterine Cervical Neoplasms / pathology

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  • (PMID = 20403053.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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79. Colecchia M, Insabato L: Pseudoglandular (adenoid, acantholytic) penile squamous cell carcinoma. Am J Surg Pathol; 2009 Sep;33(9):1421-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudoglandular (adenoid, acantholytic) penile squamous cell carcinoma.
  • [MeSH-major] Acantholysis / pathology. Carcinoma, Squamous Cell / secondary. Penile Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Middle Aged. Treatment Outcome

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  • [CommentOn] Am J Surg Pathol. 2009 Apr;33(4):551-5 [19033863.001]
  • (PMID = 19609203.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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80. Sung A, Bergsneider M, Wang MB: Transnasal endoscopic surgery of the cavernous sinus for tissue diagnosis. Laryngoscope; 2010 Feb;120(2):282-4
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transnasal endoscopic surgery of the cavernous sinus for tissue diagnosis.
  • [MeSH-minor] Aged. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / secondary. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Female. Humans. Male

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  • (PMID = 19950384.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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