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1. Dores GM, Huycke MM, Devesa SS, Garcia CA: Primary cutaneous adenoid cystic carcinoma in the United States: incidence, survival, and associated cancers, 1976 to 2005. J Am Acad Dermatol; 2010 Jul;63(1):71-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous adenoid cystic carcinoma in the United States: incidence, survival, and associated cancers, 1976 to 2005.
  • BACKGROUND: Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare appendageal tumor of uncertain origin.
  • [MeSH-major] Carcinoma, Adenoid Cystic / epidemiology. Skin Neoplasms / epidemiology
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / epidemiology. Survival Rate. United States / epidemiology

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  • [Copyright] Copyright (c) 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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  • (PMID = 20447723.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CP010183-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS135983; NLM/ PMC2885489
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2. Xu YG, Hinshaw M, Longley BJ, Ilyas H, Snow SN: Cutaneous adenoid cystic carcinoma with perineural invasion treated by mohs micrographic surgery-a case report with literature review. J Oncol; 2010;2010:469049

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  • [Title] Cutaneous adenoid cystic carcinoma with perineural invasion treated by mohs micrographic surgery-a case report with literature review.
  • We report a 58-year-old woman with cutaneous adenoid cystic carcinoma arising on the chest treated with Mohs micrographic surgery.
  • To date, only six other cases of cutaneous adenoid cystic carcinoma were reportedly managed by Mohs surgery.
  • Cutaneous adenoid cystic carcinoma has low potential for distant metastasis but is notorious for its aggressive infiltrative growth pattern, frequent perineural invasion, and high risk of local recurrence after excision.
  • We propose that Mohs surgery is an ideal method to achieve margin-free removal of cutaneous adenoid cystic carcinoma.

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  • (PMID = 20379385.001).
  • [ISSN] 1687-8469
  • [Journal-full-title] Journal of oncology
  • [ISO-abbreviation] J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2850546
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3. Singh A, Ramesh V: Primary cutaneous adenoid cystic carcinoma with distant metastasis: a case report and brief literature review. Indian J Dermatol Venereol Leprol; 2010 Mar-Apr;76(2):176-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous adenoid cystic carcinoma with distant metastasis: a case report and brief literature review.
  • Primary adenoid cystic carcinoma (PCACC) of skin is a rare tumor, and those who show distant metastasis are even rarer.
  • We report a case of PCACC on the face of a 55-year-old man who showed bilateral lung metastasis and on palliative chemotherapy showed significant regression of the primary tumor.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 20228549.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 11
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4. Lee MW, Batoroev YK, Odashiro AN, Nguyen GK: Solitary metastatic cancer to the thyroid: a report of five cases with fine-needle aspiration cytology. Cytojournal; 2007;4:5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Four patients were known to have a solid cancer treated by radical surgery 1 to 4 years prior [1 bronchogenic squamous cell carcinoma, 1 parotid adenoid cystic carcinoma, 1 renal cell carcinoma (RCC) and 1 cutaneous melanoma], and 1 patient had no past history of cancer.
  • In 1 patient the thyroid FNA revealed a metastatic RCC that led to the discovery of a clinically occult RCC.

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  • (PMID = 17263878.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1808473
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5. Naylor E, Sarkar P, Perlis CS, Giri D, Gnepp DR, Robinson-Bostom L: Primary cutaneous adenoid cystic carcinoma. J Am Acad Dermatol; 2008 Apr;58(4):636-41
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  • [Title] Primary cutaneous adenoid cystic carcinoma.
  • Primary cutaneous adenoid cystic carcinoma is a rare, slow-growing malignancy first described by Boggio in 1975.
  • This tumor characteristically consists of basophilic cells with a distinct adenoid or cribriform pattern in the mid to deep reticular dermis.
  • Definitive diagnosis relies on the characteristic histologic features and the exclusion of metastatic disease.
  • [MeSH-major] Carcinoma, Adenoid Cystic / ultrastructure. Head and Neck Neoplasms / ultrastructure. Scalp. Skin Neoplasms / ultrastructure

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  • (PMID = 18342709.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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6. Aneiros-Fernandez J, Husein-ElAhmed H, Arias-Santiago S, Nicolae A, O'Valle-Ravassa F: Unknown: A woman with an erythematous nodule on the scalp. Dermatol Online J; 2010;16(4):12
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  • The rest of her cutaneous exam was normal.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Head and Neck Neoplasms / diagnosis. Scalp. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Telangiectasis / diagnosis. Telangiectasis / pathology. Telangiectasis / surgery

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  • (PMID = 20409419.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Perez DE, Magrin J, de Almeida OP, Kowalski LP: Multiple cutaneous metastases from a parotid adenoid cystic carcinoma. Pathol Oncol Res; 2007;13(2):167-9
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  • [Title] Multiple cutaneous metastases from a parotid adenoid cystic carcinoma.
  • Cutaneous metastasis from salivary gland adenoid cystic carcinoma is extremely rare.
  • We report a case of a 39-year-old man that presented multiple cutaneous metastases from a parotid salivary gland adenoid cystic carcinoma.
  • This case shows the importance of a detailed and periodical skin examination in patients treated for salivary gland adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Parotid Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Gene Expression Regulation, Neoplastic. Humans. Keratin-7 / genetics. Keratin-7 / metabolism. Male. Proto-Oncogene Proteins c-kit / genetics. Proto-Oncogene Proteins c-kit / metabolism. Skin / metabolism. Skin / pathology. Vimentin / genetics. Vimentin / metabolism

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  • (PMID = 17607381.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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8. Kim C, Kovich OI, Dosik J: Brooke-Spiegler syndrome. Dermatol Online J; 2007;13(1):10
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  • A 46-year-old woman with Brooke-Spiegler syndrome has multiple cutaneous adnexal neoplasms on her face and scalp.
  • Etiology, clinical features, malignant transformation, and treatment modalities for Brooke-Spiegler syndrome are reviewed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Face. Female. Humans. Middle Aged. Scalp. Syndrome

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  • (PMID = 17511943.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Yamada T, Mouri H, Izumi K, Takeuchi S, Ohtsubo K, Yamashita K, Yasumoto K, Kitamura S, Yano S: [Combined chemotherapy with cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1545-8
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  • [Title] [Combined chemotherapy with cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma].
  • We report a case of a 65-year-old man with metastatic primary cutaneous adenoid cystic carcinoma that was effectively treated by combination chemotherapy with cisplatin (CDDP) plus vinorelbine(VNR).
  • He was given a diagnosis of primary cutaneous adenoid cystic carcinoma with metastatic lesions to multiple lungs and left tibial bone and then given chemotherapy combining CDDP plus VNR as the first treatment in December 2008.
  • We reported the efficacy of combined treatment with CDDP plus VNR for primary cutaneous adenoid cystic carcinoma, because this clinical condition was very rare and the standard treatment has still not been established.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Cisplatin / therapeutic use. Lung Neoplasms / drug therapy. Skin Neoplasms / drug therapy. Vinblastine / analogs & derivatives

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  • (PMID = 20716883.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; Q6C979R91Y / vinorelbine
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10. Barnes J, Garcia C: Primary cutaneous adenoid cystic carcinoma: a case report and review of the literature. Cutis; 2008 Mar;81(3):243-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous adenoid cystic carcinoma: a case report and review of the literature.
  • Primary cutaneous adenoid cystic carcinoma is a rare cancer, with only 61 cases reported in the literature.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Surgical Flaps

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  • (PMID = 18441847.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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11. Fueston JC, Gloster HM, Mutasim DF: Primary cutaneous adenoid cystic carcinoma: a case report and literature review. Cutis; 2006 Mar;77(3):157-60
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous adenoid cystic carcinoma: a case report and literature review.
  • Primary cutaneous adenoid cystic carcinoma (ACC) is a rare tumor, with less than 50 cases reported to date.
  • We report an additional case of primary cutaneous ACC arising on the scalp of a 57-year-old woman.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / pathology

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  • (PMID = 16610734.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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12. Cansu DU, Kasifoglu T, Açkaln M, Korkmaz C: The development of primary cutaneous adenoid cystic carcinoma in a patient with ankylosing spondylitis treated with etanercept. South Med J; 2009 Jul;102(7):738-40
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  • [Title] The development of primary cutaneous adenoid cystic carcinoma in a patient with ankylosing spondylitis treated with etanercept.
  • The case of a patient with ankylosing spondylitis who developed cutaneous adenoid cystic carcinoma after three years of treatment with anti-TNF-alpha therapy is discussed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / chemically induced. Immunoglobulin G / adverse effects. Immunosuppressive Agents / adverse effects. Skin Neoplasms / chemically induced. Spondylitis, Ankylosing / drug therapy


13. Alfaro-Rubio A, Sanmartín Jiménez O, Serra-Guillén C, Requena Caballero C, Hueso Gabriel L, Botella-Estrada R, Nagore Enguídanos E, Llombart Cussac B, Guillén Barona C: [Adenoid cystic carcinoma]. Actas Dermosifiliogr; 2006 Nov;97(9):578-80
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  • [Title] [Adenoid cystic carcinoma].
  • [Transliterated title] Carcinoma adenoide quístico.
  • Adenoid cystic carcinoma is an uncommon tumor of the head and neck.
  • Although it is mainly located in the salivary gland, a skin location has also been described.
  • After resection, the histological diagnosis was adenoid cystic carcinoma.
  • Its histological diagnosis was lymphatic metastasis due to adenoid cystic carcinoma.
  • Primary cutaneous adenoid cystic carcinoma is a very uncommon tumor in which treatment consists in extensive local excision with free margins.
  • Multicenter, prospective studies are necessary to determine the best treatment and especially the adjuvant treatment for adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lip Neoplasms / pathology

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  • (PMID = 17173761.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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14. Xia Y, Xu S, Liu X, Chen AC: Photodynamic therapy as consolidation treatment for primary cutaneous adenoid cystic carcinoma: a case report. Photomed Laser Surg; 2010 Oct;28(5):707-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Photodynamic therapy as consolidation treatment for primary cutaneous adenoid cystic carcinoma: a case report.
  • OBJECTIVE: The purpose of this case report was to evaluate the efficacy of photodynamic therapy (PDT) for a patient with primary cutaneous adenoid cystic carcinoma (PCACC).
  • After performing a local resection along a margin of 0.5 cm beyond the surrounding tissue, PCACC was clearly revealed based on the histological features and the exclusion of differentiation of other metastasis in the skin.
  • RESULTS: The 40-month follow-up diagnosis showed no evidence of recurrence or metastasis observed on the treated area.
  • [MeSH-major] Aminolevulinic Acid / administration & dosage. Carcinoma, Adenoid Cystic / therapy. Facial Neoplasms / therapy. Photochemotherapy / methods. Skin Neoplasms / therapy. Surgical Procedures, Operative / methods

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  • (PMID = 20929386.001).
  • [ISSN] 1557-8550
  • [Journal-full-title] Photomedicine and laser surgery
  • [ISO-abbreviation] Photomed Laser Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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15. Albores-Saavedra J, Heard SC, McLaren B, Kamino H, Witkiewicz AK: Cylindroma (dermal analog tumor) of the breast: a comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast. Am J Clin Pathol; 2005 Jun;123(6):866-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cylindroma (dermal analog tumor) of the breast: a comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast.
  • We compared 4 breast cylindromas with 50 dermal cylindromas and 8 adenoid cystic breast carcinomas.
  • Except for a modest increase in the number of eccrine ducts and reactive Langerhans cells in dermal cylindromas, breast and dermal cylindromas showed identical histologic and immunohistochemical features.
  • Clusters of sebaceous cells and a few eccrine ducts are described in breast cylindromas.
  • Eccrine ducts were highlighted by epithelial membrane antigen and carcinoembryonic antigen.
  • Cylindromas of the breast and skin did not express cytokeratin 20, gross cystic disease fluid protein 15, or estrogen or progesterone receptor.
  • Breast cylindroma might be confused with the solid variant of adenoid cystic carcinoma, especially in needle core biopsy specimens, because they share nodular and trabecular patterns, basaloid cells, myoepithelial cells, eccrine ducts, and hyaline globules of basement membrane material.
  • However, adenoid cystic carcinoma displays an infiltrative growth pattern, cytologic atypia, and mitotic figures and lacks the continuous, thickened basement membrane.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Sweat Glands / pathology

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  • (PMID = 15899777.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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16. Benchetritt M, Butori C, Long E, Ilie M, Ferrari E, Hofman P: Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: diagnostic cytopathology from an exfoliative sample. Diagn Cytopathol; 2008 May;36(5):351-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: diagnostic cytopathology from an exfoliative sample.
  • Adenoid cystic carcinoma (ACC) occurs not only as a tumor of salivary glands, but also in very unusual locations, such as in the skin.
  • Only very few cases of primary cutaneous of ACC have metastasized to the lymph nodes and lungs.
  • We present a 53-year-old man with metastasis of the pericardium from a primary cutaneous ACC (PCACC) of the scalp, which had been surgically treated 14 years ago.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Heart Neoplasms / secondary. Pericardial Effusion / pathology. Pericardium / pathology. Skin Neoplasms / pathology

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  • (PMID = 18418850.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Goto H, Yamamoto T, Ishiyama Z, Usui M, Okada S: Adenoid cystic carcinoma arising from the lower eyelid. Jpn J Ophthalmol; 2006 Jul-Aug;50(4):374-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma arising from the lower eyelid.
  • BACKGROUND: Primary cutaneous adenoid cystic carcinoma is one of the rarest eyelid tumors.
  • OBSERVATIONS: Under a clinical diagnosis of chalazion, the eyelid induration was extracted surgically via the palpebral conjunctiva.
  • Histopathological examination of the extracted tumor revealed proliferation of basaloid cells with a prominent cribriform pattern containing Alcian blue-positive and periodic acid Schiff-positive material, leading to a diagnosis of adenoid cystic carcinoma.
  • CONCLUSIONS: Adenoid cystic carcinoma should be considered as a differential diagnosis of eyelid tumors simulating chalazion.
  • Adenoid cystic carcinoma in the eyelid may have a more favorable prognosis than that in the lacrimal gland.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Eyelid Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Ophthalmologic Surgical Procedures

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  • [Copyright] Copyright (c) Japanese Ophthalmological Society 2006.
  • (PMID = 16897224.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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18. Schmaltz R, Müller CS, Vogt T: [Sudden growth of previously indolent scalp nodule]. Hautarzt; 2010 Jun;61(6):518-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cylindromas are benign adnexal tumors with eccrine and apocrine differentiation.
  • Malignant changes are rare; possible clues are ulceration, bleeding or sudden growth of the lesions.
  • We present a case of scalp cylindromatosis in which a primary cutaneous adenoid-cystic carcinoma developed.
  • As our case shows, histological evaluation is mandatory, even when the clinical diagnosis seems obvious.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Cell Transformation, Neoplastic / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Multiple Primary / diagnosis. Scalp. Skin Neoplasms / diagnosis

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  • [Cites] Br J Dermatol. 2001 Oct;145(4):653-6 [11703297.001]
  • [Cites] Dermatol Surg. 2003 Jun;29(6):647-9 [12786711.001]
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  • (PMID = 20490442.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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19. Yurut-Caloglu V, Caloglu M, Ozyilmaz F, Saynak M, Cosar-Alas R, Karagol H, Bayir-Angin G, Uzal C: Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature. Med Oncol; 2007;24(4):458-62
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature.
  • Adenoid cystic carcinoma is the second most common malignancy of the major and minor salivary glands after mucoepidemoid carcinoma.
  • Skeletal muscle and cutaneous metastases from adenoid cystic carcinoma of the parotid gland are extremely rare.
  • In this case, a 40-year-old man with lung and bone metastases followed by skeletal muscle and cutaneous metastases from adenoid cystic carcinoma of the right parotid gland is presented.
  • [MeSH-major] Bone Neoplasms / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis. Muscle Neoplasms / diagnosis. Parotid Neoplasms / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 17917100.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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20. Petersson F, Kutzner H, Spagnolo DV, Bisceglia M, Kacerovska D, Vazmitel M, Michal M, Kazakov DV: Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome. Am J Dermatopathol; 2009 Oct;31(7):642-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome.
  • Spiradenoma is a benign, morphologically well-defined cutaneous adnexal neoplasm that is closely related to cylindroma.
  • We present the rare occurrence of adenoid cystic carcinoma (ACC)-like areas in 7 spiradenomas and 1 spiradenocylindroma, not described in the English literature to date.
  • Although well-developed bilayered glands with a demonstrable peripheral myoepithelial cell layer were not recognizable in the ACC-like areas, immunohistochemistry demonstrated myoepithelial differentiation in these portions of the tumors.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Syndrome

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  • (PMID = 19633533.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Rütten A, Requena L: [Sweat gland carcinomas of the skin]. Hautarzt; 2008 Feb;59(2):151-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sweat gland carcinomas of the skin].
  • Sweat gland carcinomas are rare malignant tumors of the skin.
  • The well-defined entities porocarcinoma, microcystic adnexal carcinoma, aggressive digital papillary adenocarcinoma, mucinous eccrine carcinoma, adenoid cystic carcinoma, spiradenocarcinoma, cylindrocarcinoma, hidradenocarcinoma are described.
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / therapy

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  • [Cites] Br J Dermatol. 2000 Apr;142(4):688-93 [10792218.001]
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  • (PMID = 18214401.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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22. Adamski H, Le Lan J, Chevrier S, Cribier B, Watier E, Chevrant-Breton J: Primary cutaneous cribriform carcinoma: a rare apocrine tumour. J Cutan Pathol; 2005 Sep;32(8):577-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous cribriform carcinoma: a rare apocrine tumour.
  • BACKGROUND: Primary cutaneous cribriform carcinoma (PCCC) is a rare apocrine tumour occurring in middle-aged people.
  • The histopathological diagnosis is difficult, mainly because this tumour is exceptional.
  • Differential diagnoses, including cutaneous metastasis of adenocarcinoma, adenoid basal cell carcinoma and adenoid cystic carcinoma, are discussed.
  • [MeSH-minor] Adult. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Humans. Male. Treatment Outcome

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  • (PMID = 16115058.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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23. Rütten A, Kutzner H, Mentzel T, Hantschke M, Eckert F, Angulo J, Rodríguez Peralto JL, Requena L: Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm. J Am Acad Dermatol; 2009 Oct;61(4):644-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm.
  • BACKGROUND: Cribriform carcinoma is the histopathologic variant of cutaneous apocrine carcinoma characterized by interconnected solid aggregations of neoplastic cells that are punctuated by small round spaces.
  • OBJECTIVE: To describe the histopathologic and immunohistochemical characteristics of this under-recognized cutaneous adnexal neoplasm.
  • METHODS: Twenty-six cases of primary cutaneous cribriform apocrine carcinoma were clinically, histopathologically, and immunohistochemically studied.
  • CONCLUSIONS: Primary cutaneous cribriform apocrine carcinoma is a distinctive but little-known variant of cutaneous apocrine carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology
  • [MeSH-minor] Adult. Aged. Apocrine Glands / pathology. Biopsy. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cytoplasm / pathology. Cytoplasm / ultrastructure. Diagnosis, Differential. Epithelial Cells / pathology. Epithelial Cells / ultrastructure. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron. Microvilli / pathology. Microvilli / ultrastructure. Middle Aged. Young Adult

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  • [CommentIn] J Am Acad Dermatol. 2011 Mar;64(3):599-601 [21315957.001]
  • (PMID = 19751882.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Scott AR, Faquin WC, Deschler DG: Parotid mass in a woman with multiple cutaneous cylindromas. Head Neck; 2010 May;32(5):684-7
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid mass in a woman with multiple cutaneous cylindromas.
  • BACKGROUND: Familial autosomal dominant cylindromatosis (FADC) is a rare disease characterized by multiple cutaneous cylindromas, trichoepitheliomas, and spiradenomas.
  • We present a case of a woman with scalp lesions and a parotid mass.
  • METHODS: Biopsy of a skin nodule demonstrated cylindroma, and fine-needle aspiration of the parotid mass suggested membranous basal cell adenoma, which was confirmed following superficial parotidectomy.
  • Seventeen cases involved the parotid gland; there are 2 reports of malignant transformation.
  • Membranous basal cell adenoma may be mistaken for adenoid cystic carcinoma on cytologic or histologic examination.
  • Total parotidectomy with facial nerve preservation or superficial parotidectomy with close follow-up is recommended, as multifocality and malignant transformation exist.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19455704.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Fernandez-Flores A, Pol A, Juanes F, Crespo LG: Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies. Med Mol Morphol; 2007 Dec;40(4):212-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies.
  • We report a cribriform carcinoma of the left fossa poplitea in a 62-year-old woman.
  • The patient did not present any symptoms, and the only complaint was the nodule, which was resected for diagnosis.
  • After considering different diagnostic options, we decided that the most appropriate one was cribriform carcinoma, which is an entity described in 1998.
  • The diagnostic criteria, which were provided in the few publications that refer to this entity, helped us to distinguish it from the main mimicker: cystic adenoid carcinoma.
  • [MeSH-major] Adenocarcinoma / immunology. Adenocarcinoma / pathology. Antibodies, Neoplasm / immunology. Skin Neoplasms / immunology. Skin Neoplasms / pathology

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  • [Cites] J Clin Pathol. 2005 Jul;58(7):757-61 [15976347.001]
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  • (PMID = 18085381.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm
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26. Fresini A, Rossiello L, Severino BU, Del Prete M, Satriano RA: Giant basal cell carcinoma. Skinmed; 2007 Jul-Aug;6(4):204-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant basal cell carcinoma.
  • A 72-year-old white man presented with a large cutaneous tumor on his back.
  • Perilesional skin appeared edematous, probably owing to inflammation and impaired lymphatic flow.
  • Histologic examination of a biopsy specimen taken from the margin of the lesion displayed a superficial area of ulceration and invasion of the deeper dermis and subcutaneous tissue (Figure 2A and Figure 2B).
  • The tumor mostly showed an adenoid pattern: gland-like structures and cystic spaces sometimes containing amorphous or granular material, surrounded by strands of basaloid cells devoid of any peripheral palisading (Figure 2C).
  • In some areas, the adenoid pattern coexisted with infiltrated areas characterized by thin and elongated strands or cords of basaloid cells with irregular and jagged peripheral contours within a fibrous or edematous stroma (Figure 2D).
  • Therefore, a diagnosis of basal cell carcinoma, adenoid subtype, was made.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 17618177.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Kazakov DV, Kutzner H, Rütten A, Mukensnabl P, Michal M: Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma. Am J Dermatopathol; 2005 Jun;27(3):195-203
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma.
  • This report emphasizes a carcinoid-like pattern, a previously unrecognized feature in cutaneous sebaceous neoplasms.
  • The cases included 6 men and 1 woman, with their ages at the diagnosis ranging from 43 to 87 years (median age, 59).
  • Sebaceous differentiation in the form of mature sebocytes varied from almost none to approximately 10%.
  • Four lesions represented sebaceomas, and in 1 case microscopic delineation between a carcinoma and sebaceoma was difficult.
  • No neuroendocrine differentiation was demonstrated immunohistochemically, histochemically, and ultrastructurally.
  • Electron microscopic examination performed in 1 case of carcinoma revealed lipid vacuoles in a minority of cells.
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Diagnosis, Differential. Female. History, 16th Century. Humans. Immunohistochemistry. Inclusion Bodies / pathology. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / ultrastructure. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 15900121.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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28. Retamar RA, Stengel F, Saadi ME, Kien MC, Della Giovana P, Cabrera H, Chouela EN: Brooke-Spiegler syndrome - report of four families: treatment with CO2 laser. Int J Dermatol; 2007 Jun;46(6):583-6
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  • BACKGROUND: Brooke-Spiegler syndrome is a well known but rare cutaneous disorder characterized by the presence of multiple trichoepitheliomas and cylindromas.
  • [MeSH-major] Adenoma, Sweat Gland / surgery. Carcinoma, Adenoid Cystic / surgery. Laser Therapy. Neoplasms, Adnexal and Skin Appendage / surgery. Neoplasms, Multiple Primary / surgery. Neoplastic Syndromes, Hereditary / surgery. Skin Neoplasms / surgery

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  • (PMID = 17550556.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Quatresooz P, Piérard GE: Distinct expression patterns of alpha1 (IV) and alpha5 (IV) collagen chains in cylindroma and malignant cylindroma. Int J Mol Med; 2005 Jan;15(1):27-31
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  • [Title] Distinct expression patterns of alpha1 (IV) and alpha5 (IV) collagen chains in cylindroma and malignant cylindroma.
  • Cutaneous cylindromas are considered to derive from cells of the sweat gland apparatus.
  • The aim was to study the distribution of the alpha1 (IV) and alpha5 (IV) collagen chains in cylindromas and malignant cylindroma, and to compare it with the BM of sweat glands.
  • Seven cylindromas and one malignant cylindroma were studied.
  • The malignant cylindroma showed a linear immunoreactivity for the alpha1 (IV) collagen chain undistinguishable from the pattern seen in the benign cylindromas.
  • No immunoreactivity was present for the alpha5 (IV) collagen chain in the malignant neoplasm.
  • The distinctive patterns of expression of the alpha1 (IV) and alpha5 (IV) collagen chains may be related to the histogenic sudoral origin of cylindromas without any relationship with the benign or malignant nature of the neoplasm.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Collagen Type IV / metabolism. Gene Expression Regulation, Neoplastic

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  • (PMID = 15583824.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Collagen Type IV
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30. Kazakov DV, Benkova K, Michal M, Vanecek T, Kacerovska D, Skalova A: Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. Hum Pathol; 2009 Oct;40(10):1499-503

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene.
  • It appears identical to cutaneous cylindroma, hence the synonym dermal analogue tumor.
  • We present a case of a tumor involving the parotid gland that appeared identical to cutaneous spiradenoma.
  • In addition, the lesion had a malignant component identical to basal cell adenocarcinoma.
  • This is the first report of a "dermal analogue tumor" of the salivary gland that resembled a cutaneous spiradenoma and not a cylindroma.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Parotid Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 19454360.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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31. Carlsten JR, Lewis MD, Saddler K, Reilly P, Pan T, Gnepp DR, Robinson-Bostom L: Spiradenocylindrocarcinoma: a malignant hybrid tumor. J Cutan Pathol; 2005 Feb;32(2):166-71
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  • [Title] Spiradenocylindrocarcinoma: a malignant hybrid tumor.
  • BACKGROUND: Eccrine spiradenomas and cylindromas are benign, slowly growing, cutaneous adnexal neoplasms, recently hypothesized to arise from a common pluripotential cell; malignant variants are rare.
  • We found 48 cases of malignant spiradenomas and 33 cases of malignant cylindromas reported in the English literature.
  • CASE REPORT: We describe two cases of a malignant variant of this rare hybrid tumor occurring in a 62-year-old male and a 72-year-old female.
  • CONCLUSION: We propose the term 'spiradenocylindrocarcinoma' to describe malignant tumors with features of both a spiradenoma and a cylindroma.
  • In conjunction with histological features of malignancy, p53 and Ki-67 immunohistochemical staining may provide helpful clues in determining the malignant potential of this tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [ErratumIn] J Cutan Pathol. 2005 Jul;32(6):453
  • (PMID = 15606677.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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32. Stoica LE, Georgescu CV, Pătraşcu V, Radu CC, Tolea I, Mogoantă L: Basal cell carcinomas - clinical-evolutional and histopahotologic aspects. Curr Health Sci J; 2009 Oct;35(4):228-33

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  • Basal cell carcinoma (BCC) is the most frequent cutaneous tumour.
  • A clinical data was drawn for the patients, containing the identification data, environment, profession, cancer localisation and history of the disease, clinical and histopathologic diagnosis.
  • Results. In our lot, the most numerous cases were of pearly BCC (33.6%), nodular BCC (22.2%), respectively scar plane BCC (13.1%).Regarding the histopathologic type, the repartition was as it follows: solid BCC (33.7%), polymorph (19.2%), adenoid (13.1%), keratinised (11.8%), superficial (7.0%), cystic (3.8%), pigmented (3.8%), scleroderma form (2.2%), in situ (1.4%).

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  • (PMID = 24778822.001).
  • [ISSN] 2067-0656
  • [Journal-full-title] Current health sciences journal
  • [ISO-abbreviation] Curr Health Sci J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Other-IDs] NLM/ PMC3945250
  • [Keywords] NOTNLM ; basal cell carcinoma / evolution / histopathology
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33. Kazakov DV, Soukup R, Mukensnabl P, Boudova L, Michal M: Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):27-33
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  • [Title] Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation.
  • Brooke-Spiegler syndrome is an autosomal dominantly inherited disease with predisposition to cutaneous adnexal neoplasms, most commonly cylindromas and trichoepitheliomas.
  • The histopathological survey revealed a plethora of benign adnexal neoplasms showing apocrine, follicular, and sebaceous differentiation occurring independently and conjointly.
  • Some spiradenocylindromas demonstrated prominent sebaceous or trichoblastomatous differentiation or both.
  • The occurrence of sebaceous and trichoblastic differentiation in spiradenocylindromas is a further proof that spiradenoma and cylindroma are not eccrine tumors but neoplasms of the folliculosebaceousapocrine unit.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hair Diseases / metabolism. Hair Diseases / pathology. Hair Diseases / surgery. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Immunoenzyme Techniques. Male. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Syndrome

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  • (PMID = 15677973.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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34. Rajan N, Langtry JA, Ashworth A, Roberts C, Chapman P, Burn J, Trainer AH: Tumor mapping in 2 large multigenerational families with CYLD mutations: implications for disease management and tumor induction. Arch Dermatol; 2009 Nov;145(11):1277-84
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  • Differentiation between the clinical diagnoses has little prognostic or clinical utility in genetic counseling, even within individuals from the same family.
  • Thus, we suggest an encompassing diagnosis of "CYLD cutaneous syndrome."
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Genetic Predisposition to Disease / epidemiology. Germ-Line Mutation. Head and Neck Neoplasms / genetics. Skin Neoplasms / diagnosis. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age of Onset. Biopsy, Needle. Child. Cohort Studies. DNA Mutational Analysis. Deafness / diagnosis. Female. Follow-Up Studies. Gene Expression Regulation, Neoplastic. Genetic Testing / methods. Humans. Immunohistochemistry. Incidence. Male. Middle Aged. Pedigree. Phenotype. Risk Factors. Scalp / surgery. Sensitivity and Specificity. Sex Distribution. Sexual Dysfunction, Physiological / diagnosis. Syndrome. Young Adult

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  • (PMID = 19917957.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / A8363; United Kingdom / Medical Research Council / / G0701367; United Kingdom / Medical Research Council / / G0701367(84978); United Kingdom / Cancer Research UK / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
  • [Other-IDs] NLM/ PMC2935681; NLM/ UKMS31751
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35. Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E: Perineural tumor spread. Neuroimaging Clin N Am; 2008 May;18(2):413-29, xi
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  • PNS is more frequently associated with carcinoma arising from minor or major salivary glands (more often adenoid cystic carcinoma), mucosal or cutaneous squamous cell carcinoma, basal cell carcinoma, melanoma, lymphoma, and sarcoma.
  • Therefore, radiologists must be aware of the relevant cranial nerve anatomy and thoroughly scrutinize not only the nerves close to the primary tumor site but also the whole neural pathways that can be accessed by PNS.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Cranial Nerve Neoplasms / secondary. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / secondary

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  • (PMID = 18466839.001).
  • [ISSN] 1052-5149
  • [Journal-full-title] Neuroimaging clinics of North America
  • [ISO-abbreviation] Neuroimaging Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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36. De Francesco V, Frattasio A, Pillon B, Stinco G, Scott CA, Trotter D, Patrone P: Carcinosarcoma arising in a patient with multiple cylindromas. Am J Dermatopathol; 2005 Feb;27(1):21-6
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  • Malignant tumors may occur, usually with the features of a cylindrocarcinoma.
  • The authors describe the case of a 75-year-old woman with the Brooke-Spiegler syndrome who presented with multiple nodules of the scalp, face, and trunk.
  • In 1997 she underwent surgical excision of the entire forehead and scalp with skin grafting.
  • The lesion was excised and histologic and immunohistochemical evaluation revealed a malignant cutaneous biphasic tumor extending into the subcutis, consisting of a major portion with the features of an adnexal carcinoma and of a minor one of atypical spindle cells.
  • Biphasic malignant skin tumors are rare and only a limited number have been described, none in association with the Brooke-Spiegler syndrome.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Skin Appendage / pathology. Carcinosarcoma / pathology. Neoplasms, Second Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Skin Transplantation. Treatment Outcome

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  • (PMID = 15677972.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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37. Kazakov DV, Schaller J, Vanecek T, Kacerovska D, Michal M: Brooke-Spiegler syndrome: report of a case with a novel mutation in the CYLD gene and different types of somatic mutations in benign and malignant tumors. J Cutan Pathol; 2010 Aug;37(8):886-90
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  • [Title] Brooke-Spiegler syndrome: report of a case with a novel mutation in the CYLD gene and different types of somatic mutations in benign and malignant tumors.
  • The available histopathological material included 24 trichoepitheliomas, 2 large nodular basal cell carcinomas (BCCs), 2 spiradenomas, 1 spiradenocylindroma and 1 trichoblastoma composed of large and small nodules with prominent clear cell differentiation.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Basal Cell / genetics. Carcinoma, Skin Appendage / genetics. Facial Neoplasms / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 20132422.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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38. Alix T, Labbé D, Caquant L, Comoz F, Compère JF, Bénateau H: [Management of whole-scalp tumour: the Poncet-Spiegler cylindroma or turban tumour]. Rev Stomatol Chir Maxillofac; 2009 Apr;110(2):109-12
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  • INTRODUCTION: The Poncet-Spiegler cylindroma (PSC) is a benign annexal cutaneous tumor which preferentially develops on the scalp, neck, or forehead.
  • The treatment was a complete scalp exeresis and secondary reconstruction with a skin graft.
  • In case of turban tumor, total scalp exeresis and secondary reconstruction with a skin graft is recommended.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Head and Neck Neoplasms / surgery. Scalp / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adult. Esthetics. Female. Follow-Up Studies. Humans. Neoplasm Recurrence, Local / surgery. Reconstructive Surgical Procedures. Skin Transplantation / methods

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  • (PMID = 19328506.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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39. Gildea JH, Lillehei KO, Golitz LE, Kleinschmidt-DeMasters BK: Benign cylindroma causing transcalvarial invasion in a patient with familial cylindromatosis. Clin Neuropathol; 2007 May-Jun;26(3):125-30
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  • Light microscopic and immunohistochemical characterization of resected tumor, with TP53 immunostaining in the invasive tumor was compared with that seen in five other cutaneous, non-invasive cylindromas.
  • While an uncommon occurrence, both benign and malignant cylindromas have the capacity to invade bone, particularly in patients with the familial syndrome.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Neoplastic Syndromes, Hereditary / pathology. Scalp / pathology. Skin Neoplasms / pathology. Skull / pathology


40. Mashkevich G, Undavia S, Iacob C, Arigo J, Linstrom C: Malignant cylindroma of the external auditory canal. Otol Neurotol; 2006 Jan;27(1):97-101
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  • [Title] Malignant cylindroma of the external auditory canal.
  • OBJECTIVE: This report describes a case of a malignant cylindroma arising in the external auditory canal.
  • CONCLUSION: To our knowledge, this is the first report describing a malignant degeneration of cylindroma in the external auditory canal.
  • This tumor represents an extremely rare cutaneous neoplasm, thus raising diagnostic and therapeutic challenges.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Ear Canal / surgery. Ear Neoplasms / surgery. Sebaceous Gland Neoplasms / surgery

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  • (PMID = 16371854.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Ramalingam SS, Kummar S, Sarantopoulos J, Shibata S, LoRusso P, Yerk M, Holleran J, Lin Y, Beumer JH, Harvey RD, Ivy SP, Belani CP, Egorin MJ: Phase I study of vorinostat in patients with advanced solid tumors and hepatic dysfunction: a National Cancer Institute Organ Dysfunction Working Group study. J Clin Oncol; 2010 Oct 10;28(29):4507-12
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  • PURPOSE: Vorinostat is the first US Food and Drug Administration-approved histone deacetylase inhibitor and is indicated for the treatment of refractory cutaneous T-cell lymphoma.
  • Of five patients with adenoid cystic carcinoma, one patient had a partial response, and four patients had stable disease.
  • A patient with papillary thyroid carcinoma had stable disease for more than 2 years.

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  • [Cites] Clin Cancer Res. 2007 Jun 15;13(12):3605-10 [17510206.001]
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  • (PMID = 20837947.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U01-CA099168; United States / NCI NIH HHS / CM / N01 CM-62208; United States / NCRR NIH HHS / RR / 5M01 RR 00056; United States / NCI NIH HHS / CA / N01CM62208; United States / NCI NIH HHS / CA / U01 CA062487; United States / NCRR NIH HHS / RR / M01 RR000056; United States / NCI NIH HHS / CA / U01 CA-062487; United States / NCI NIH HHS / CA / P30 CA047904; United States / NCI NIH HHS / CA / U01 CA-062505; United States / NCI NIH HHS / CO / N01-CO-124001; United States / NCI NIH HHS / CA / U01 CA099168; United States / NCI NIH HHS / CA / P30CA47904; United States / NCI NIH HHS / CA / U01 CA062505
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Hydroxamic Acids; 58IFB293JI / vorinostat
  • [Other-IDs] NLM/ PMC2988640
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42. Torres T, Caetano M, Alves R, Horta M, Selores M: Tender tumor of the scalp: clinicopathologic challenge. Primary cutaneous adenoid cystic carcinoma. Int J Dermatol; 2010 Jun;49(6):605-7
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tender tumor of the scalp: clinicopathologic challenge. Primary cutaneous adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Pain / pathology. Scalp. Skin Neoplasms / pathology. Telangiectasis / pathology

  • Genetic Alliance. consumer health - Adenoid Cystic Carcinoma.
  • MedlinePlus Health Information. consumer health - Pain.
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  • (PMID = 20618463.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Numajiri T, Nishino K, Uenaka M: Giant primary cutaneous adenoid cystic carcinoma of the perineum: histological and radiological correlations. Acta Derm Venereol; 2008;88(3):316-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant primary cutaneous adenoid cystic carcinoma of the perineum: histological and radiological correlations.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Perineum / surgery. Skin Neoplasms / pathology

  • Genetic Alliance. consumer health - Adenoid Cystic Carcinoma.
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  • (PMID = 18480953.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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44. Sammour R, Lafaille P, Joncas V, Krasny M, Wong J, Allaire G, Bernstein S: Adenoid cystic carcinoma of the eyelid: a rare cutaneous tumor treated with Mohs micrographic surgery. Dermatol Surg; 2009 Jun;35(6):997-1000
Genetic Alliance. consumer health - Adenoid Cystic Carcinoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the eyelid: a rare cutaneous tumor treated with Mohs micrographic surgery.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Eyelid Neoplasms / surgery. Mohs Surgery / methods

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  • (PMID = 19397655.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Lian F, Cockerell CJ: Cutaneous appendage tumors: familial cylindromatosis and associated tumors update. Adv Dermatol; 2005;21:217-34
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for familial cylindromatosis .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous appendage tumors: familial cylindromatosis and associated tumors update.
  • [MeSH-major] Carcinoma, Skin Appendage. Sweat Gland Neoplasms
  • [MeSH-minor] Acrospiroma. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Genes, Tumor Suppressor. Humans. Mutation. Tumor Suppressor Proteins / genetics

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  • (PMID = 16350444.001).
  • [ISSN] 0882-0880
  • [Journal-full-title] Advances in dermatology
  • [ISO-abbreviation] Adv Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 52
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46. Behroozan DS, Goldberg LH, Glaich AS, Kaplan B, Kaye VN: Mohs micrographic surgery for deeply penetrating, expanding benign cutaneous neoplasms. Dermatol Surg; 2006 Jul;32(7):958-65
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mohs micrographic surgery for deeply penetrating, expanding benign cutaneous neoplasms.
  • [MeSH-major] Mohs Surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adult. Carcinoma / pathology. Carcinoma / surgery. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Epidermal Cyst / pathology. Epidermal Cyst / surgery. Female. Forehead / pathology. Granular Cell Tumor / pathology. Granular Cell Tumor / surgery. Heel / pathology. Humans. Male. Middle Aged. Neoplasm Metastasis. Nose / pathology. Pilomatrixoma / pathology. Pilomatrixoma / surgery. Scalp / pathology

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  • (PMID = 16875482.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Shams PN, Olver JM: A case of cutaneous collision tumour: the importance of photographic documentation and large incisional biopsy. Eye (Lond); 2006 Nov;20(11):1324-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of cutaneous collision tumour: the importance of photographic documentation and large incisional biopsy.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 16575419.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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48. Humphreys T: Surgical management of cylindromatosis. Skinmed; 2010 Sep-Oct;8(5):289-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Facial Neoplasms / surgery. Skin Transplantation / methods
  • [MeSH-minor] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Skin Appendage / diagnosis. Carcinoma, Skin Appendage / pathology. Carcinoma, Skin Appendage / surgery. Follow-Up Studies. Humans. Neoplastic Syndromes, Hereditary / diagnosis. Neoplastic Syndromes, Hereditary / pathology. Neoplastic Syndromes, Hereditary / surgery. Skin Neoplasms

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  • (PMID = 21137639.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Familial cylindromatosis
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