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1. Wu H, Huang Q, Wang ZY, Cao RP, Zhang ZH: [Surgery of jugular foramen region tumors]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Sep;41(9):665-8
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  • The mastoid and neck approach, the infratemporal fossa approach with and without rerouting the facial nerve, the combined transcochlear and infratemporal fossa approach were respectively used according to the tumor type, size, auditory, facial and lower cranial nerve functions.
  • RESULTS: In this series of 32 patients, 13 were paragangliomas, 10 schwannomas,2 meningiomas, 2 giant cell tumors, 1 chondrosarcoma, 1 mucochondrosarcoma, 1 adenoid cystic carcinoma, 1 rhabdomyosarcoma and 1 case cholesterol Granuloma.

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  • (PMID = 17111806.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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2. Teymoortash A, Pientka A, Schrader C, Tiemann M, Werner JA: Expression of galectin-3 in adenoid cystic carcinoma of the head and neck and its relationship with distant metastasis. J Cancer Res Clin Oncol; 2006 Jan;132(1):51-6
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  • [Title] Expression of galectin-3 in adenoid cystic carcinoma of the head and neck and its relationship with distant metastasis.
  • PURPOSE: Adenoid cystic carcinoma (ACC) is one of the most common malignant tumours of the salivary glands characterized by multiple recurrences and distant metastasis resulting in significantly worsening prognosis.
  • There was no statistical significance in the correlation of galectin-3 expression and disease-free survival and overall survival rate (P=0.095 and 0.102, respectively).
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. Carcinoma, Adenoid Cystic / pathology. Galectin 3 / analysis. Head and Neck Neoplasms / chemistry. Head and Neck Neoplasms / pathology

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  • (PMID = 16184379.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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3. Keikhaee MR, Kudo Y, Siriwardena S, Wu L, Ogawa I, Takata T: Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid cystic carcinoma. Virchows Arch; 2007 May;450(5):567-74
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  • [Title] Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid cystic carcinoma.
  • Adenoid cystic carcinoma (ACC) is a malignant salivary gland tumor, which shows frequent recurrence and metastasis, ultimately with a poor outcome.
  • In this study, we transfected nondegradable p27 mutant (T187A) and wild-type gene into ACC cell line.
  • These findings, overall, suggest that Skp2 may play an important role in ACC development through the down-regulation of p27 and that Skp2 siRNA can be a novel modality of cancer gene therapy for suppression of p27 down-regulation in ACC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Cell Proliferation. Cyclin-Dependent Kinase Inhibitor p27 / metabolism. S-Phase Kinase-Associated Proteins / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17431674.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proliferating Cell Nuclear Antigen; 0 / RNA, Small Interfering; 0 / S-Phase Kinase-Associated Proteins; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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4. Güerrissi JO, Quiroga JP: Adnexal carcinomas of the head and neck. Indian J Plast Surg; 2008 Jul;41(2):229-34
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  • [Title] Adnexal carcinomas of the head and neck.
  • Adnexal carcinomas of the skin are rare and they derive from structures such as sweat glands, sebaceous glands, and hair follicles.
  • Adnexal tumors represent 1-2% of skin cancers.
  • Four (50%) of them had malignant cylindromas, two (25%) had sebaceous carcinoma, and the other two (25%) syringoid eccrine carcinoma.

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  • (PMID = 19753272.001).
  • [ISSN] 0970-0358
  • [Journal-full-title] Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • [ISO-abbreviation] Indian J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2740523
  • [Keywords] NOTNLM ; Adnexal carcinomas / adnexal tumors / skin cancer
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5. Santos RR, Damasceno RW, de Pontes FS, Cursino SR, Nishiwaki-Dantas MC, Vital Filho J, Dantas PE: Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings. Arq Bras Oftalmol; 2010 Jan-Feb;73(1):33-9
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  • [Title] Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings.
  • PURPOSE: To describe and analyze the features of a cases series of patients with primary epithelial neoplasms of the lacrimal gland, its surgical treatment, and histopathological findings.
  • RESULTS: During the study period, there were 12 patients, 5 (41.7%) with benign tumors, all pleomorphic adenomas (benign mixed tumor) and 7 (58.3%) with malignant neoplasms, thus distributed: four cases of adenoid cystic carcinoma, two of mucoepidermoid carcinoma and one carcinoma expleomorphic adenoma.
  • Three patients developed distant metastasis and died of disease.
  • CONCLUSIONS: The most frequent primary epithelial neoplasms of the lacrimal gland were pleomorphic adenoma and adenoid cystic carcinoma during the study period.
  • The histopathological diagnosis and the disease initial stage can play a significant role in patient's survival.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Lacrimal Apparatus / pathology. Lacrimal Apparatus Diseases / pathology

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  • (PMID = 20464111.001).
  • [ISSN] 1678-2925
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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6. Copelli C, Bianchi B, Ferrari S, Ferri A, Sesenna E: Malignant tumors of intraoral minor salivary glands. Oral Oncol; 2008 Jul;44(7):658-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Between 1995 and 2004, 43 patients with intraoral minor salivary gland carcinomas were diagnosed and treated at the Department of Maxillofacial Surgery, University of Parma, Italy.
  • Adenoid cystic carcinoma was the most common histological type (60.6%), followed by mucoepidermoid carcinoma (27.9%).
  • Disease-free intervals ranged from 1 month to 9 years and 13.9% of the patients had local failure, whereas 25,6% had distant metastases.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / surgery. Salivary Gland Neoplasms / surgery

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  • (PMID = 17996484.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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7. Freier K, Flechtenmacher C, Walch A, Ohl S, Devens F, Burke B, Hassfeld S, Lichter P, Joos S, Hofele C: Copy number gains on 22q13 in adenoid cystic carcinoma of the salivary gland revealed by comparative genomic hybridization and tissue microarray analysis. Cancer Genet Cytogenet; 2005 May;159(1):89-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Copy number gains on 22q13 in adenoid cystic carcinoma of the salivary gland revealed by comparative genomic hybridization and tissue microarray analysis.
  • Adenoid cystic carcinoma (ACC) of the salivary gland is a neoplasm characterized by slow but inevitable local progression and terminal hematogenous metastasis.
  • We therefore assume that copy number gain of 22q13 is a novel frequent finding in ACC that may be involved in the initial pathogenesis of this neoplasm by proto-oncogene activation.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 22 / genetics. Microarray Analysis. Nucleic Acid Hybridization. Salivary Gland Neoplasms / genetics

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  • (PMID = 15860365.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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8. Zhang N, Zhang DS, Han JQ, Zhang SZ, Liu GJ, Wei FC, Zhang J, Mu WL: [Radiosensitization by double suicide gene system in ACC-2 cell]. Shanghai Kou Qiang Yi Xue; 2009 Apr;18(2):183-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To investigate the radiosensitization by prodrug and CD-TK double suicide gene therapy system in adenoid cystic carcinoma cells (ACC-2).
  • [MeSH-minor] Carcinoma, Adenoid Cystic. Cell Line, Tumor. Genetic Therapy. Humans. Plasmids. Transfection. X-Rays

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  • (PMID = 19417997.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.1.21 / Thymidine Kinase; EC 3.5.4.1 / Cytosine Deaminase
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9. Ayadi K, Ayadi L, Daoud E, Mnif Z, Ben Mahfoudh K, Boudawara T, Mnif J: Adenoid cystic carcinoma of the parotid with facial nerve invasion. Tunis Med; 2010 Jan;88(1):46-8
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  • [Title] Adenoid cystic carcinoma of the parotid with facial nerve invasion.
  • BACKGROUND: Adenoid cystic carcinoma comprises approximately 10% of all epithelial salivary neoplasms and most frequently involves the parotid.
  • AIM: The authors report a case of parotid adenoid cystic carcinoma with invasion and spread via the facial nerve with an emphasis on radiologic features.
  • OBSERVATION: We report a case of a 47-year-old man presenting with a right submandibular mass evolving for 4 years.
  • Pathologic examination of the resected specimen revealed histological features of adenoid cystic carcinoma with intra neural invasion of the mastoid segment of the facial nerve.
  • CONCLUSION: This study confirms that multiplanar approach of MRI allows rapid detection of adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Facial Nerve / pathology. Parotid Neoplasms / diagnosis

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  • (PMID = 20415214.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Tunisia
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10. Mataix J, Bañuls J, Botella R, Laredo C, Lucas A: [Brooke-Spiegler syndrome: an heterogeneous entity]. Actas Dermosifiliogr; 2006 Dec;97(10):669-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Síndrome de Brooke-Spiegler: una entidad heterogénea.
  • The Brooke-Spiegler syndrome is a rare, autosomally dominant disease with a predisposition to develop different adnexal tumors.
  • Clinically it is characterized by the presence of multiple cylindromas, trichoepitheliomas, and occasionally, spiradenomas.
  • In this article we present the case of a woman and her daughter, both affected by this rare genodermatosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Neoplasms, Basal Cell / genetics. Neoplasms, Multiple Primary / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adult. Child. Facial Neoplasms / diagnosis. Facial Neoplasms / genetics. Female. Genes, Dominant. Humans. Phenotype

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  • (PMID = 17173833.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 30
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11. Chang CH, Shu MT, Lee JC, Leu YS, Chen YC, Lee KS: Treatments and outcomes of malignant tumors of external auditory canal. Am J Otolaryngol; 2009 Jan-Feb;30(1):44-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Primary cancer of the external auditory canal (EAC) is a rare disease with poor prognosis.
  • METHODS: We retrospectively reviewed the patients treated for primary cancer of EAC between 1991 and 2002 at our hospital, which is a tertiary referral center.
  • RESULTS: Ten patients had squamous cell carcinoma and 2 had adenoid cystic carcinoma (ACC).
  • Five patients had stage I disease, 2 with stage II, 1 with stage III, and 4 with stage IV.
  • All patients (n = 7) with early stage (I or II) were disease-free, but only 1 of 5 patients with late stage (III or IV) was disease-free.
  • Only one patient with complete resection had recurrence and the histologic diagnosis of this particular patient was ACC.
  • CONCLUSIONS: Patients with early-stage cancer can benefit from less aggressive surgical interventions without significant morbidity or mortality.
  • No recurrence occurred in patients with complete resection except the one with ACC.
  • The result of our institute was comparable or superior to those of other studies in early-stage disease.
  • However, patients with advanced cancer had high recurrence rate despite of adjuvant radiotherapy, suggesting more aggressive surgical approach for complete resection was necessary.
  • [MeSH-minor] Adult. Aged. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / therapy. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Cohort Studies. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Otologic Surgical Procedures / methods. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Taiwan

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  • (PMID = 19027512.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Musani MA, Sohail Z, Zafar S, Malik S: Morphological pattern of parotid gland tumours. J Coll Physicians Surg Pak; 2008 May;18(5):274-7
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  • Pleomorphic adenoma was most common benign tumor (83.5%), followed by Warthins tumour.
  • The most common malignant tumour was mucoepidermoid carcinoma (60%), followed by adenoid cystic carcinoma.
  • Parotid swelling for years was main feature of benign tumours, whereas malignant tumours presented with pain, fixation to skin or underlying structure, cervical lymphadenopathy and facial palsy.
  • CONCLUSION: Pleomorphic adenoma was the most common benign tumour and mucoepidermoid carcinoma was most common malignant tumour.
  • [MeSH-major] Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Fine-Needle. Child. Diagnosis, Differential. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Morbidity / trends. Neoplasm Staging / methods. Pakistan / epidemiology. Retrospective Studies. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 18541080.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Pakistan
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13. Lacrimal Gland Tumor Study Group: An epidemiological survey of lacrimal fossa lesions in Japan: number of patients and their sex ratio by pathological diagnosis. Jpn J Ophthalmol; 2005 Sep-Oct;49(5):343-8
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  • [Title] An epidemiological survey of lacrimal fossa lesions in Japan: number of patients and their sex ratio by pathological diagnosis.
  • PURPOSE: To report the results of a survey conducted on lacrimal fossa lesions in Japan.
  • We sent survey questionnaires to 1201 hospitals with training facilities accredited by the Japanese Ophthalmological Society and determined the number of patients and their sex ratio by pathological diagnosis.
  • RESULTS: Among tumors with high frequency, there were 86 cases of pleomorphic adenoma and 19 cases of adenoid cystic carcinoma in the category of epithelial tumor; 55 cases of malignant lymphoma and 32 cases of reactive lymphoid hyperplasia in the category of nonepithelial tumor; and 50 cases of inflammation and 22 cases of cystic lesion in the category of nonneoplastic lesion.
  • CONCLUSIONS: The sex ratio by pathological diagnosis revealed that women had a higher rate than men of pleomorphic adenoma, whereas men had a higher rate than women of malignant epithelial tumor.

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  • (PMID = 16187032.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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14. Lupinetti AD, Roberts DB, Williams MD, Kupferman ME, Rosenthal DI, Demonte F, El-Naggar A, Weber RS, Hanna EY: Sinonasal adenoid cystic carcinoma: the M. D. Anderson Cancer Center experience. Cancer; 2007 Dec 15;110(12):2726-31
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  • [Title] Sinonasal adenoid cystic carcinoma: the M. D. Anderson Cancer Center experience.
  • BACKGROUND: Adenoid cystic carcinoma of the sinonasal tract is a rare cancer that accounts for 10% of all malignancies at this site.
  • The objective of the current study was to evaluate prognostic factors, treatment outcomes, recurrence patterns, and survival rates for sinonasal adenoid cystic carcinoma.
  • Between 1990 and 2004, 105 patients were evaluated for adenoid cystic carcinoma of the sinonasal tract at a single institution.
  • RESULTS: One hundred five patients with adenoid cystic carcinoma were evaluated, including 58 women and 47 men.
  • The majority of patients presented with T3/T4 (76.7%), N0 (98%), M0 (97%) disease.
  • Eighty-four percent of patients underwent surgery and received postoperative radiation as treatment for their primary disease.
  • The 5-year overall survival and disease specific survival rates were 62.9% and 70.9%, respectively.
  • CONCLUSIONS: Adenoid cystic carcinoma of the paranasal sinuses is a rare disease, and the ideal treatment paradigm has yet to be defined.
  • Although local recurrences develop in a significant percentage of patients, survival from this disease exceeds that of other sinonasal malignancies.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Paranasal Sinus Neoplasms / therapy

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  • [Copyright] 2007 American Cancer Society
  • (PMID = 17960615.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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15. Yasuda M, Hanagiri T, Ichiki Y, Uramoto H, Takenoyama M, Yasumoto K: Surgical treatment of patients with stenosis of the central airway due to tracheal tumours. Asian J Surg; 2010 Oct;33(4):212-7
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  • The most common histological finding was thyroid carcinoma (n = 3), followed by adenoid cystic carcinoma (n = 2), a metastatic thyroid tumour (n = 1), and a benign granular cell tumour (n = 1).

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  • [Copyright] Copyright © 2010 Asian Surgical Association. Published by Elsevier B.V. All rights reserved.
  • (PMID = 21377110.001).
  • [ISSN] 0219-3108
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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16. Bittner N, Koh WJ, Laramore GE, Patel S, Mulligan MS, Douglas JG: Treatment of locally advanced adenoid cystic carcinoma of the trachea with neutron radiotherapy. Int J Radiat Oncol Biol Phys; 2008 Oct 1;72(2):410-4
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  • [Title] Treatment of locally advanced adenoid cystic carcinoma of the trachea with neutron radiotherapy.
  • PURPOSE: To examine the efficacy of fast neutron radiotherapy in the treatment of locally advanced adenoid cystic carcinoma (ACC) of the trachea and to compare outcomes with and without high-dose-rate (HDR) endobronchial brachytherapy boost.
  • CONCLUSIONS: Fast neutron radiotherapy is an effective treatment for locally advanced adenoid cystic carcinoma of the trachea, with acceptable treatment-related toxicity.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Neutrons / therapeutic use. Tracheal Neoplasms / radiotherapy

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  • (PMID = 18374509.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iridium Radioisotopes
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17. Miller TC, Simental AA, Perez M: Sinonasal adenoid cystic carcinoma seeding to the tracheostomy site. Laryngoscope; 2006 Apr;116(4):661-2
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  • [Title] Sinonasal adenoid cystic carcinoma seeding to the tracheostomy site.
  • Neoplastic seeding of head and neck carcinomas is a well-documented but relatively rare occurrence.
  • We report a rare case of seeding of a sinonasal adenoid cystic carcinoma to a tracheostomy site.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Maxillary Sinus Neoplasms / pathology. Neoplasm Seeding. Tracheal Neoplasms / secondary. Tracheostomy / adverse effects
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 16585876.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Subhashraj K, Orafi M, Nair KV, El-Gehani R, Elarbi M: Primary malignant tumors of orofacial region at Benghazi, Libya: a 17 years review. Cancer Epidemiol; 2009 Nov;33(5):332-6
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  • Among the epithelial tumors, squamous cell carcinoma (50.6%) was the most common neoplasm, followed by mucoepidermoid carcinoma (15%) and adenoid cystic carcinoma (8.7%).

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  • (PMID = 19932650.001).
  • [ISSN] 1877-783X
  • [Journal-full-title] Cancer epidemiology
  • [ISO-abbreviation] Cancer Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 35
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19. Driemel O, Maier H, Kraft K, Haase S, Hemmer J: Flow cytometric DNA ploidy in salivary gland tumours. Oncol Rep; 2005 Jan;13(1):161-5
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  • The malignant tumours consisted of 18 adenoid cystic adenomas, 10 mucoepidermoid carcinomas, 5 acinic cell carcinomas, 5 carcinoma in pleomorphic adenoma as well as of 12 other malignancies belonging to 7 different tumour entities.
  • Examination of consecutive slides actually revealed small assemblies of carcinoma cells that required a final diagnosis as non-invasive carcinoma in pleomorphic adenoma.
  • [MeSH-major] DNA, Neoplasm / analysis. Flow Cytometry. Ploidies. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 15583819.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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20. Lima RA, Tavares MR, Dias FL, Kligerman J, Nascimento MF, Barbosa MM, Cernea CR, Soares JR, Santos IC, Salviano S: Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg; 2005 Nov;133(5):702-8
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  • OBJECTIVE: To analyze the factors in parotid malignant epithelial tumors influencing recurrences and disease-specific survival.
  • The influence of selected factors on the 10 year disease-specific survival was analyzed using the Kaplan-Meier actuarial method and the log-rank test.
  • RESULTS: Forty patients had mucoepidermoid carcinoma, 18 patients adenocarcinoma NOS, 18 patients acinic cell carcinoma, 15 patients adenoid cystic carcinoma, 11 patients malignant mixed tumor, 11 patients salivary duct carcinoma, and 13 patients other pathology.
  • The 10-year disease-specific survival was 97% for stage I, 81% for stage II, 56% for stage III, and 20% for stage IV.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / therapy. Neoplasm Invasiveness / pathology. Parotid Neoplasms / mortality. Parotid Neoplasms / therapy

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  • (PMID = 16274796.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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21. Azoulay S, Laé M, Fréneaux P, Merle S, Al Ghuzlan A, Chnecker C, Rosty C, Klijanienko J, Sigal-Zafrani B, Salmon R, Fourquet A, Sastre-Garau X, Vincent-Salomon A: KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. Mod Pathol; 2005 Dec;18(12):1623-31
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  • [Title] KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome.
  • Recent biological studies have classified breast carcinomas into HER2-overexpressing, estrogen receptor-positive/luminal, basal- and normal-like groups.
  • According to this new biological classification, the objectives of our study were to assess the clinical, morphologic and immunophenotypic characteristics of adenoid cystic carcinoma of the breast in order to classify this subtype of breast carcinoma.
  • A total of 18 cases of adenoid cystic carcinoma were identified from the Institut Curie files.
  • Two patients died (one of them treated by radiation therapy only died from her disease).
  • Our study shows that adenoid cystic carcinoma of the breast is a special, estrogen receptor, progesterone receptor, HER-2 negative and highly KIT-positive, basal-like breast carcinoma, associated with an excellent prognosis.
  • This highly specific immunophenotype could be useful to differentiate adenoid cystic carcinoma of the breast from other subtypes of breast carcinoma such as cribriform carcinoma.
  • [MeSH-major] Breast Neoplasms / metabolism. Carcinoma, Adenoid Cystic / metabolism. Proto-Oncogene Proteins c-kit / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Disease-Free Survival. Female. Humans. Immunoenzyme Techniques. Keratins / metabolism. Middle Aged. Neoplasm Staging. Prognosis. Receptor, ErbB-2 / metabolism. Treatment Outcome

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  • (PMID = 16258515.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, ErbB-2
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22. Schwentner I, Obrist P, Thumfart W, Sprinzl G: Distant metastasis of parotid gland tumors. Acta Otolaryngol; 2006 Apr;126(4):340-5
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  • The incidence of distant metastasis in head and neck cancer and especially in salivary gland cancer is relatively low in comparison to other malignancies.
  • However, the presence of distant metastasis heralds a poor prognosis in head and neck cancer, with a median survival of 4.3-7.3 months.
  • The likelihood of developing distant metastasis is associated with high-grade tumors, such as adenoid cystic carcinoma, salivary duct carcinoma, high-grade mucoepidermoid carcinoma and tumors located in the submandibular gland, posterior tongue and pharyngeal tumors.
  • On the basis of a clinical case regarding a patient with metastatic parotid gland cancer we present a review of the literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ileal Neoplasms / secondary. Parotid Neoplasms / pathology
  • [MeSH-minor] Aged. Bone Neoplasms / secondary. Brain Neoplasms / secondary. Carcinoma, Acinar Cell / pathology. Carcinoma, Acinar Cell / secondary. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / secondary. Carcinoma, Mucoepidermoid / pathology. Carcinoma, Mucoepidermoid / secondary. Fatal Outcome. Humans. Immunohistochemistry. Incidence. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Male. Parotid Gland / pathology. Parotid Gland / surgery. Salivary Ducts / pathology. Tomography, X-Ray Computed

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  • (PMID = 16608783.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 32
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23. Handra-Luca A, Planchard D, Fouret P: Docetaxel-cisplatin-radiotherapy in adenoid cystic carcinoma with high-grade transformation. Oral Oncol; 2009 Nov;45(11):e208-9
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  • [Title] Docetaxel-cisplatin-radiotherapy in adenoid cystic carcinoma with high-grade transformation.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Adenoid Cystic / therapy. Maxillary Sinus Neoplasms / therapy. Mouth Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Combined Modality Therapy / methods. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / therapy. Radiotherapy, Conformal. Taxoids / administration & dosage. Tomography, X-Ray Computed

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  • (PMID = 19502105.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Taxoids; 15H5577CQD / docetaxel; Q20Q21Q62J / Cisplatin
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24. Weigelt B, Horlings HM, Kreike B, Hayes MM, Hauptmann M, Wessels LF, de Jong D, Van de Vijver MJ, Van't Veer LJ, Peterse JL: Refinement of breast cancer classification by molecular characterization of histological special types. J Pathol; 2008 Oct;216(2):141-50
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  • [Title] Refinement of breast cancer classification by molecular characterization of histological special types.
  • Most invasive breast cancers are classified as invasive ductal carcinoma not otherwise specified (IDC NOS), whereas about 25% are defined as histological 'special types'.
  • These special-type breast cancers are categorized into at least 17 discrete pathological entities; however, whether these also constitute discrete molecular entities remains to be determined.
  • Current therapy decision-making is increasingly governed by the molecular classification of breast cancer (luminal, basal-like, HER2+).
  • The molecular classification is derived from mainly IDC NOS and it is unknown whether this classification applies to all histological subtypes.
  • We aimed to refine the breast cancer classification systems by analysing a series of 11 histological special types [invasive lobular carcinoma (ILC), tubular, mucinous A, mucinous B, neuroendocrine, apocrine, IDC with osteoclastic giant cells, micropapillary, adenoid cystic, metaplastic, and medullary carcinoma] using immunohistochemistry and genome-wide gene expression profiling.
  • Hierarchical clustering analysis confirmed that some histological special types constitute discrete entities, such as micropapillary carcinoma, but also revealed that others, including tubular and lobular carcinoma, are very similar at the transcriptome level.
  • When classified by expression profiling, IDC NOS and ILC contain all molecular breast cancer types (ie luminal, basal-like, HER2+), whereas histological special-type cancers, apart from apocrine carcinoma, are homogeneous and only belong to one molecular subtype.
  • Our analysis also revealed that some special types associated with a good prognosis, such as medullary and adenoid cystic carcinomas, display a poor prognosis basal-like transcriptome, providing strong circumstantial evidence that basal-like cancers constitute a heterogeneous group.
  • Taken together, our results imply that the correct classification of breast cancers of special histological type will allow a more accurate prognostication of breast cancer patients and facilitate the identification of optimal therapeutic strategies.
  • [MeSH-major] Breast Neoplasms / classification. Carcinoma, Ductal, Breast / classification. Gene Expression Regulation, Neoplastic


25. Blake PW, Toro JR: Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling. Hum Mutat; 2009 Jul;30(7):1025-36
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  • Germline mutations in the cylindromatosis (CYLD) gene have been described in families with cylindromas, trichoepitheliomas, and/or spiradenomas.
  • Brooke-Spiegler syndrome (BSS) is the autosomal dominant predisposition to skin appendageal neoplasms including cylindromas, trichoepitheliomas, and/or spiradenomas.


26. Kassam AB, Prevedello DM, Carrau RL, Snyderman CH, Gardner P, Osawa S, Seker A, Rhoton AL Jr: The front door to meckel's cave: an anteromedial corridor via expanded endoscopic endonasal approach- technical considerations and clinical series. Neurosurgery; 2009 Mar;64(3 Suppl):ons71-82; discussion ons82-3
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  • The most frequent abnormalities encountered were adenoid cystic carcinoma, meningioma, and schwannomas.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Cranial Fossa, Middle / surgery. Endoscopy / methods. Meningioma / surgery. Nasal Cavity / surgery. Neurilemmoma / surgery. Neurosurgical Procedures / methods. Skull Base Neoplasms / surgery

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  • (PMID = 19240575.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Bilsky MH, Bentz B, Vitaz T, Shah J, Kraus D: Craniofacial resection for cranial base malignancies involving the infratemporal fossa. Neurosurgery; 2005 Oct;57(4 Suppl):339-47; discussion 339-47
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  • METHODS: At Memorial Sloan-Kettering Cancer Center, 25 patients underwent anterolateral cranial base resections for tumors that involved the infratemporal fossa during a 7-year period.
  • The most common tumors were sarcoma (n = 9), squamous cell carcinoma (n = 6), and adenoid cystic carcinoma (n = 3).
  • Twelve patients underwent Type 1 dissection for tumors involving only the infratemporal fossa and maxillary sinus; 2 patients underwent Type 2 dissections involving the infratemporal fossa and anterior cranial base; and 11 patients underwent Type 3 dissection, which included the infratemporal fossa, anterior cranial base, and orbit.

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  • (PMID = 16234683.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA009685
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS15707; NLM/ PMC1858642
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28. Hotte SJ, Winquist EW, Lamont E, MacKenzie M, Vokes E, Chen EX, Brown S, Pond GR, Murgo A, Siu LL: Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit: a Princess Margaret Hospital phase II consortium study. J Clin Oncol; 2005 Jan 20;23(3):585-90
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  • [Title] Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit: a Princess Margaret Hospital phase II consortium study.
  • PURPOSE: This study aimed to assess the antitumor activity of imatinib in adenoid cystic carcinoma (ACC) of the salivary gland expressing c-kit.
  • A high level of c-kit expression has been identified in more than 90% of ACCs.
  • Nine patients had stable disease as best response.
  • Six patients had progressive disease after two cycles.
  • Overexpression of wild-type c-kit was not sufficient for clinical benefit from imatinib in ACC.
  • Accrual to this study was rapid for a relatively rare cancer, encouraging additional efforts to identify more effective systemic therapy for these patients.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / drug therapy. Piperazines / therapeutic use. Proto-Oncogene Proteins c-kit / biosynthesis. Pyrimidines / therapeutic use. Salivary Gland Neoplasms / drug therapy

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  • [CommentIn] J Clin Oncol. 2005 Sep 1;23(25):6271-3; author reply 6273-4 [16135502.001]
  • (PMID = 15659505.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CM / N01 CM 17102-01; United States / NCI NIH HHS / CM / N01 CM 17107-01
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Biomarkers, Tumor; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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29. Retamar RA, Stengel F, Saadi ME, Kien MC, Della Giovana P, Cabrera H, Chouela EN: Brooke-Spiegler syndrome - report of four families: treatment with CO2 laser. Int J Dermatol; 2007 Jun;46(6):583-6
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  • BACKGROUND: Brooke-Spiegler syndrome is a well known but rare cutaneous disorder characterized by the presence of multiple trichoepitheliomas and cylindromas.
  • [MeSH-major] Adenoma, Sweat Gland / surgery. Carcinoma, Adenoid Cystic / surgery. Laser Therapy. Neoplasms, Adnexal and Skin Appendage / surgery. Neoplasms, Multiple Primary / surgery. Neoplastic Syndromes, Hereditary / surgery. Skin Neoplasms / surgery

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  • (PMID = 17550556.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Costa AF, Demasi AP, Bonfitto VL, Bonfitto JF, Furuse C, Araújo VC, Metze K, Altemani A: Angiogenesis in salivary carcinomas with and without myoepithelial differentiation. Virchows Arch; 2008 Oct;453(4):359-67
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  • [Title] Angiogenesis in salivary carcinomas with and without myoepithelial differentiation.
  • To investigate whether salivary carcinomas with and without myoepithelial differentiation could present differences regarding degree of angiogenesis, we compared tumor vascularization between adenoid cystic (31 cases) and epithelial-myoepithelial carcinomas (14) versus mucoepidermoid (37) carcinoma.
  • Microvascular density for CD34 and CD105 were significantly lower in carcinomas with myoepithelial differentiation.
  • High-grade peroxiredoxin I expression was found in 73.7% of mucoepidermoid carcinomas, whereas 85.1% of carcinomas with myoepithelial differentiation presented low-grade expression.
  • In conclusion, carcinomas with myoepithelial differentiation, regardless of the amounts of myoepithelial cells, are associated to a significantly lower vascular density.
  • The reasons for this lower angiogenic activity remain to be determined but could be related to metabolic characteristics of the cancer cells.
  • [MeSH-minor] Adult. Aged. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Cell Differentiation. Endoglin. Female. Humans. Male. Middle Aged. Myoepithelioma / pathology. Receptors, Cell Surface / metabolism

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  • (PMID = 18795324.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / ENG protein, human; 0 / Endoglin; 0 / Receptors, Cell Surface
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31. Pommier P, Liebsch NJ, Deschler DG, Lin DT, McIntyre JF, Barker FG 2nd, Adams JA, Lopes VV, Varvares M, Loeffler JS, Chan AW: Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg; 2006 Nov;132(11):1242-9
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  • [Title] Proton beam radiation therapy for skull base adenoid cystic carcinoma.
  • OBJECTIVE: To determine the treatment outcome and prognostic factors in patients with adenoid cystic carcinoma of the skull base treated with proton beam radiation therapy.
  • PATIENTS: From 1991 to 2002, 23 patients with newly diagnosed adenoid cystic carcinoma with skull base extension were treated with combined proton and photon radiotherapy.
  • MAIN OUTCOME MEASURES: Locoregional control and disease-free survival and overall survival rates.
  • The disease-free and overall survival rates at 5 years were 56% and 77%, respectively.
  • CONCLUSIONS: High-dose conformal proton beam radiation therapy results in a very encouraging local control rate in patients with adenoid cystic carcinoma of the skull base.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Skull Base Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Carbon. Cavernous Sinus. Cranial Fossa, Posterior. Disease-Free Survival. Female. Humans. Male. Middle Aged. Nasopharyngeal Neoplasms / pathology. Neoplasm Metastasis. Neoplasm Recurrence, Local. Neutrons. Paranasal Sinus Neoplasms / pathology. Prognosis. Protons. Radiotherapy / adverse effects. Radiotherapy Dosage. Retrospective Studies. Salvage Therapy. Sphenoid Sinus. Survival Rate. Treatment Outcome

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  • (PMID = 17116822.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons; 7440-44-0 / Carbon
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32. Di Tommaso L, Kuhn E, Kurrer M, Zettl A, Marx A, Müller-Hermelink HK, Roncalli M, Rosai J: Thymic tumor with adenoid cystic carcinomalike features: a clinicopathologic study of 4 cases. Am J Surg Pathol; 2007 Aug;31(8):1161-7
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  • [Title] Thymic tumor with adenoid cystic carcinomalike features: a clinicopathologic study of 4 cases.
  • Thymic carcinomas are rare malignant neoplasms which comprise several histologic subtypes.
  • Adenoid cystic carcinoma (ACC) is included among these subtypes even if it has never been formally reported.
  • We evaluated the clinical, radiologic, morphologic, immunohistochemical, and genetic features of 4 cases of thymic neoplasms with ACC-like features retrieved from the authors' consult files.
  • The clinical history (no evidence of ACC in other sites), radiologic findings (a mass in the thymic region), and morphologic features (residual thymic tissue at the periphery of the neoplasm) strongly supported their primary thymic nature.
  • We have interpreted them as a microscopic subtype of well-differentiated thymic carcinoma of low-grade malignancy, an impression supported by the admittedly limited follow-up information.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Thymus Neoplasms / pathology

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  • (PMID = 17667537.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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33. Gomez DR, Hoppe BS, Wolden SL, Zhung JE, Patel SG, Kraus DH, Shah JP, Ghossein RA, Lee NY: Outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: a recent experience. Int J Radiat Oncol Biol Phys; 2008 Apr 1;70(5):1365-72
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  • [Title] Outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: a recent experience.
  • PURPOSE: To analyze the recent experience of patients with adenoid cystic carcinoma treated with radiation therapy at Memorial Sloan-Kettering Cancer Center.
  • METHODS AND MATERIALS: From 1990 to 2004, a total of 59 patients with a diagnosis of primary adenoid cystic carcinoma of the head and neck received radiation therapy at our institution.
  • Five-year and 10-year rates of disease-free and overall survival were 76%/40% and 87%/65%, respectively.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Head and Neck Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Analysis of Variance. Disease-Free Survival. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Radiation Injuries / complications. Radiotherapy, Conformal / methods. Retrospective Studies. Treatment Outcome

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  • (PMID = 18029108.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Sbitti Y, Kadiri H, Fetohi M, Elghissassi I, M'rabti H, Boutayeb S, Ichou M, Boussen H, Errihani H: [Primary adenoid cystic carcinoma in breast]. Cancer Radiother; 2009 Jan;13(1):65-8
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  • [Title] [Primary adenoid cystic carcinoma in breast].
  • [Transliterated title] Carcinome adénoïde kystique primitif du sein.
  • Adenoid cystic carcinoma (ACC) of the breast is a rare neoplasm.
  • Diagnosis was based on final histopathological exam completed by immunohistochemistry or after slides review.
  • [MeSH-major] Breast Neoplasms. Carcinoma, Adenoid Cystic

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  • (PMID = 19097926.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 18
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35. Sun ZJ, Chen G, Hu X, Zhang W, Liu Y, Zhu LX, Zhou Q, Zhao YF: Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin. Apoptosis; 2010 Jul;15(7):850-63
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  • [Title] Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin.
  • The present study was to investigate the effects of quercetin on growth and apoptosis in human salivary adenoid cystic carcinoma (ACC).
  • [MeSH-major] Antineoplastic Agents / toxicity. Apoptosis. Carcinoma, Adenoid Cystic / metabolism. Quercetin / toxicity. Salivary Gland Neoplasms / metabolism. Signal Transduction / drug effects

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  • (PMID = 20386985.001).
  • [ISSN] 1573-675X
  • [Journal-full-title] Apoptosis : an international journal on programmed cell death
  • [ISO-abbreviation] Apoptosis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / NF-kappa B; 0 / Proto-Oncogene Proteins c-bcl-2; 9007-43-6 / Cytochromes c; 9IKM0I5T1E / Quercetin; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.10 / I-kappa B Kinase; EC 3.4.22.- / Caspases
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36. Carlinfante G, Lazzaretti M, Ferrari S, Bianchi B, Crafa P: P53, bcl-2 and Ki-67 expression in adenoid cystic carcinoma of the palate. A clinico-pathologic study of 21 cases with long-term follow-up. Pathol Res Pract; 2005;200(11-12):791-9
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  • [Title] P53, bcl-2 and Ki-67 expression in adenoid cystic carcinoma of the palate. A clinico-pathologic study of 21 cases with long-term follow-up.
  • Adenoid cystic carcinoma (ACC) is an indolent tumor that pursues a protracted clinical course with recurrences and late metastases.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Ki-67 Antigen / metabolism. Palatal Neoplasms / pathology. Proto-Oncogene Proteins c-bcl-2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 15792122.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53
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37. Ito FA, Ito K, Coletta RD, Graner E, de Almeida OP, Lopes MA: Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67. Anal Quant Cytol Histol; 2009 Oct;31(5):280-7
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  • STUDY DESIGN: Immunohistochemical expression of epidermal growth factor (EGF), EGFR, ErbB-2, fatty acid synthase (FAS) and Ki-67 were analyzed in 41 pleomorphic adenoma (PA), in 30 mucoepidermoid carcinoma (MEC) and in 30 adenoid cystic carcinoma (ACC) and correlated with their histologic patterns.


38. Faivre S, Raymond E, Casiraghi O, Temam S, Berthaud P: Imatinib mesylate can induce objective response in progressing, highly expressing KIT adenoid cystic carcinoma of the salivary glands. J Clin Oncol; 2005 Sep 1;23(25):6271-3; author reply 6273-4
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  • [Title] Imatinib mesylate can induce objective response in progressing, highly expressing KIT adenoid cystic carcinoma of the salivary glands.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Piperazines / therapeutic use. Proto-Oncogene Proteins c-kit / biosynthesis. Pyrimidines / therapeutic use. Salivary Gland Neoplasms / drug therapy

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  • [CommentOn] J Clin Oncol. 2005 Jan 20;23(3):585-90 [15659505.001]
  • (PMID = 16135502.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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39. Webb BD, Walsh GL, Roberts DB, Sturgis EM: Primary tracheal malignant neoplasms: the University of Texas MD Anderson Cancer Center experience. J Am Coll Surg; 2006 Feb;202(2):237-46
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  • [Title] Primary tracheal malignant neoplasms: the University of Texas MD Anderson Cancer Center experience.
  • This study was conducted to review the presentation, management, and outcomes of primary tracheal cancers at our institution, a large multidisciplinary cancer center.
  • STUDY DESIGN: Retrospective chart review was conducted for all patients found to have a pathologic diagnosis of primary tracheal malignancy.
  • Among these, 34 (45.9%) were squamous cell carcinomas, 19 (25.7%) were adenoid cystic carcinomas, and 21 (28.4%) were of other histologic types.
  • Most patients (77.3%) were former or current smokers, particularly those with squamous cell carcinoma (93.3%).
  • For the entire group of 74 patients, the 5-year disease-specific mortality rate was 72.9% and the 5-year all-cause mortality rate was 79.3%.
  • Patients who had adenoid cystic carcinoma and those with cervical primaries had better rates of disease-specific and overall survival than others (p = 0.036 and 0.006 for the former patient group and p = 0.006 and 0.030 for the latter patient group).
  • Among patients with incident disease treated at our institution (n = 45), those undergoing primary operation with adjuvant radiotherapy appeared to have better disease-specific and overall survival rates compared with those undergoing primary radiotherapy with or without chemotherapy (p = 0.0002 and 0.0003, respectively).
  • Although squamous cell carcinoma was the most common pathology in smokers, adenoid cystic carcinoma was more prevalent among nonsmokers.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / pathology. Tracheal Neoplasms / pathology

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  • (PMID = 16427548.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. González-García R, Nam-Cha SH, Muñoz-Guerra MF, Gamallo-Amat C: Basal cell adenoma of the parotid gland. Case report and review of the literature. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E206-9
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  • [Title] Basal cell adenoma of the parotid gland. Case report and review of the literature.
  • Basal cell adenoma of the salivary glands is an uncommon type of monomorphous adenoma.
  • It is also characterized by the presence of a slack and hyaline stroma and the absence of myxoid or condroid stroma.
  • In contrast to pleomorphic adenoma, it tends to be multiple and its recurrence rate after surgical excision is high.
  • Due to prognostic implications, differential diagnosis with basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell carcinoma is mandatory.
  • We describe a case of basal cell adenoma of the parotid gland.
  • We also review the literature and discuss the diagnosis and management of this rare entity.
  • [MeSH-major] Adenoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16505803.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 21
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41. Kazakov DV, Soukup R, Mukensnabl P, Boudova L, Michal M: Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):27-33
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  • [Title] Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation.
  • Brooke-Spiegler syndrome is an autosomal dominantly inherited disease with predisposition to cutaneous adnexal neoplasms, most commonly cylindromas and trichoepitheliomas.
  • The histopathological spectrum in our patient included cylindromas, spiradenomas, trichoepitheliomas, small nodular trichoblastomas, and lymphadenomas.
  • The occurrence of sebaceous and trichoblastic differentiation in spiradenocylindromas is a further proof that spiradenoma and cylindroma are not eccrine tumors but neoplasms of the folliculosebaceousapocrine unit.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hair Diseases / metabolism. Hair Diseases / pathology. Hair Diseases / surgery. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Immunoenzyme Techniques. Male. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Syndrome

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  • (PMID = 15677973.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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42. de Araújo VC, Furuse C, Cury PR, Altemani A, de Araújo NS: STAT3 expression in salivary gland tumours. Oral Oncol; 2008 May;44(5):439-45
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  • Fifty biopsies of salivary gland tumours (9 pleomorphic adenomas, 12 adenoid cystic carcinomas, 7 epithelial-myoepithelial carcinomas, 10 polymorphous low-grade adenocarcinomas and 12 mucoepidermoid carcinomas) and 10 normal salivary glands were immunohistochemically labeled for STAT3 and Phospho-STAT3 (STAT3P).
  • The results showed that, in normal salivary gland, STAT3 was expressed in cytoplasm and STAT3P in nuclei of all tissue cells, except in large mucous acinar cells for which both antibodies were negative.
  • In pleomorphic adenoma, the expression was the same as in normal glands.
  • The most important one was the presence of STAT3 in the nuclei of the malignant tumour cells, most evident in the cribriform-type of adenoid cystic carcinoma.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / metabolism. Female. Humans. Immunohistochemistry. Male

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  • (PMID = 17826306.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / STAT3 Transcription Factor
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43. Jeyanthi K, Karthikeyan R, Sherlin HJ, Anuja N, Ramani P, Priya P, Chandrasekar T, Khan N, Narayanan V: Pleomorphic adenoma in the infra-temporal space: the first case report. Head Neck Pathol; 2007 Dec;1(2):173-7
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  • [Title] Pleomorphic adenoma in the infra-temporal space: the first case report.
  • Tumours in the infratemporal fossa are very rare; therefore experience in their diagnosis and therapeutic management is very limited.
  • Tumors that are reported commonly in the infratemporal region are nasopharyngeal carcinomas, juvenile angiofibromas and adenoid cystic carcinomas.
  • To the best of our knowledge, this is the first report in the English language literature of a pleomorphic adenoma presenting in the infratemporal space and probably arising from an ectopic minor salivary gland, along with a brief description of the surgical technique.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Skull Neoplasms / pathology. Temporal Bone / pathology

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  • [Cites] Neurosurgery. 1999 Dec;45(6):1385-98 [10598707.001]
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  • (PMID = 20614271.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807513
  • [Keywords] NOTNLM ; Infratemporal fossa / Pleomorphic adenoma
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44. Barrera JE, Shroyer KR, Said S, Hoernig G, Melrose R, Freedman PD, Wright TA, Greer RO: Estrogen and progesterone receptor and p53 gene expression in adenoid cystic cancer. Head Neck Pathol; 2008 Mar;2(1):13-8
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  • [Title] Estrogen and progesterone receptor and p53 gene expression in adenoid cystic cancer.
  • OBJECTIVES: The current study examined the role of estrogen receptors (ER), progesterone receptors (PR) and p53 expression in adenoid cystic carcinoma (ACC) to determine if simple expression or possible overexpression of these products might influence the development and natural course of this cancer.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Gene Expression Regulation, Neoplastic / physiology. Genes, p53 / physiology. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism. Salivary Gland Neoplasms / metabolism

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  • [Cites] Oral Oncol. 2001 Apr;37(3):315-22 [11287288.001]
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  • (PMID = 20614336.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ PMC2807605
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Estrogen and progesterone receptors / p53 gene
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45. Nuwal P, Dixit R, Singhal AK: Primary adenoid cystic carcinoma of trachea presenting as midline neck swelling and mimicking thyroid tumor: A case report and review of literature. Lung India; 2010 Jul;27(3):167-9
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  • [Title] Primary adenoid cystic carcinoma of trachea presenting as midline neck swelling and mimicking thyroid tumor: A case report and review of literature.
  • We report an extremely rare case of primary adenoid cystic carcinoma (ACC) trachea presenting as midline swelling neck and mimicking thyroid tumor.
  • Fine needle aspiration cytology (FNAC) from swelling reveal features of papillary carcinoma thyroid.
  • Subsequently the operative findings, bronchoscopy and histological diagnosis of excised mass, along with review of FNAC, revealed features of ACC of trachea with exra tracheal extension anteriorly into the soft tissue neck, without actual invasion of the thyroid gland.
  • The cytological differential diagnosis of ACC and CT findings are also briefly discussed.

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  • (PMID = 20931039.001).
  • [ISSN] 0974-598X
  • [Journal-full-title] Lung India : official organ of Indian Chest Society
  • [ISO-abbreviation] Lung India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2946722
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma trachea / midline swelling neck / thyroid tumor
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46. Pino Rivero V, González Palomino A, Pantoja Hernández CG, Marcos García M, Trinidad Ruiz G, Pardo Romero G, Blasco Huelva A: [Sinonasal cystic adenoid carcinoma with epiphora and orbital involvement. Report of a case and review of the literature]. An Otorrinolaringol Ibero Am; 2005;32(3):245-52
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  • [Title] [Sinonasal cystic adenoid carcinoma with epiphora and orbital involvement. Report of a case and review of the literature].
  • [Transliterated title] Carcinoma adenoide quístico nasosinusal con epífora y afectación orbitaria. Presentación de un caso y revisión de la literatura.
  • We report the clinical case of a 41 years old male with nasal obstruction of 1 year, epistaxis and epiphora.
  • The biopsy was positive for cystic adenoid carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lacrimal Apparatus Diseases / pathology. Orbital Neoplasms / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 16001694.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 14
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47. Ouadnouni Y, Bouchikh M, Jahid A, Achir A, Smahi M, Msougar Y, Lakranbi M, Herrak L, Mahassini N, Benosman A: [Tracheal adenoid cystic carcinoma]. Pan Afr Med J; 2010;7:21
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  • [Title] [Tracheal adenoid cystic carcinoma].
  • [Transliterated title] Carcinome adénoïde kystique tracheal.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Dyspnea / etiology. Tracheal Neoplasms / surgery

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  • [Cites] Presse Med. 2003 Apr 5;32(13 Pt 1):602 [12718319.001]
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  • (PMID = 21918708.001).
  • [ISSN] 1937-8688
  • [Journal-full-title] The Pan African medical journal
  • [ISO-abbreviation] Pan Afr Med J
  • [Language] fre
  • [Publication-type] Journal Article
  • [Publication-country] Uganda
  • [Other-IDs] NLM/ PMC3172634
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48. Darling MR, Gauthier M, Jackson-Boeters L, Daley TD, Chambers AF, Tuck AB: Osteopontin expression in salivary gland tumours. Oral Oncol; 2006 Apr;42(4):363-9
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  • Osteopontin (OPN) is expressed in numerous carcinomas and plays a role in tumour development, invasion and metastasis.
  • This study examines by immunohistochemistry the expression of OPN in normal salivary gland tissue and three types of salivary gland tumour: pleomorphic adenoma (PA), adenoid cystic carcinoma (ACC) and polymorphous low grade adenocarcinoma (PLGA).
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Carcinoma, Adenoid Cystic / metabolism. Neoplasm Proteins / metabolism. Osteopontin / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 16321564.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 106441-73-0 / Osteopontin
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49. Bhandare N, Monroe AT, Morris CG, Bhatti MT, Mendenhall WM: Does altered fractionation influence the risk of radiation-induced optic neuropathy? Int J Radiat Oncol Biol Phys; 2005 Jul 15;62(4):1070-7
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  • METHODS AND MATERIALS: Between 1964 and 2000, 273 patients with tumors of the nasopharynx, paranasal sinuses, nasal cavity, and hard palate adenoid cystic carcinomas were treated with curative intent and had radiation fields that included the optic nerves and/or chiasm.

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  • (PMID = 15990010.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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50. Zvrko E, Golubović M: Laryngeal adenoid cystic carcinoma. Acta Otorhinolaryngol Ital; 2009 Oct;29(5):279-82
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  • [Title] Laryngeal adenoid cystic carcinoma.
  • Adenoid cystic carcinomas are malignant tumours and occur in the major and the minor salivary glands.
  • Laryngeal adenoid cystic carcinomas are rare and account for less than 1% of all malignant tumours in the larynx.
  • Adenoid cystic carcinoma is characterised by slow progression, multiple recurrences and late distant metastasis.
  • The aetiology of adenoid cystic carcinoma remains unknown.
  • In this article, the case of laryngeal adenoid cystic carcinoma is described in a 55-year-old male patient who presented with a 3-month history of prelaryngeal pain.
  • For patients with laryngeal adenoid cystic carcinomas, regular and long-term follow-up is mandatory, in order to detect relapses and metastases.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery

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  • (PMID = 20162031.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2821129
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Laryngectomy / Larynx / Malignant tumours
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51. Pino Rivero V, Pantoja Hernández CG, González Palomino A, Trinidad Ramos G, Pardo Romero G, Marcos García M, Pereda Tamayo JM, Blasco Huelva A: [Adenoid cystic carcinoma of the larynx-hypopharynx. A case report and review of the literature]. An Otorrinolaringol Ibero Am; 2006;33(4):339-45
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  • [Title] [Adenoid cystic carcinoma of the larynx-hypopharynx. A case report and review of the literature].
  • [Transliterated title] Carcinoma adenoide quístico de laringe-hipofaringe. A propósito de un caso y revisión de la literatura.
  • Laryngeal or hypopharyngeal localization of adenoid cystic carcinoma is rare due to the poor distribution of the accesory salivary glands in this area.
  • We report one case of such neoplasm on that area, with its diagnosis confirmed histologically.
  • We review the literature of this tumor whose prognosis is much worse than epidermoid or scamous carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery

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  • (PMID = 16910388.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 18
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52. Teymoortash A, Ramaswamy A, Werner JA: [Adenoid cystic carcinoma secondary to heterotopic salivary gland tissue of the cervical lymph nodes]. Laryngorhinootologie; 2007 Jan;86(1):44-7
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  • [Title] [Adenoid cystic carcinoma secondary to heterotopic salivary gland tissue of the cervical lymph nodes].
  • [Transliterated title] Adenoidzystisches Karzinom im heterotopen Speicheldrüsengewebe der zervikalen Lymphknoten.
  • BACKGROUND: The presence of heterotopic salivary gland tissue in intra-, periparotideal and cervical lymph nodes is not an uncommen finding.
  • The histological assessment of the extirpated node seemed to indicate lymph node metastasis of an adenoid cystic carcinoma.
  • RESULTS: Due to the fact of missing of a primary tumor, the diagnosis of an adenoid cystic carcinoma in heterotopic salivary gland tissue of the cervical lymph node was established after long-term observation.
  • CONCLUSION: After exclusion of an occult carcinoma of the salivary glands, the possibility of malignant transformation of heterotopic intranodal salivary gland inclusions should be considered in patients suffering from salivary gland carcinoma in the area of the cervical lymph nodes.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Cell Transformation, Neoplastic / pathology. Choristoma / pathology. Lymph Nodes / pathology. Otorhinolaryngologic Neoplasms / pathology. Salivary Glands
  • [MeSH-minor] Diagnosis, Differential. Humans. Lymph Node Excision. Male. Middle Aged

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  • (PMID = 16586289.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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53. Ward BK, Seethala RR, Barnes EL, Lai SY: Basal cell adenocarcinoma of a hard palate minor salivary gland: case report and review of the literature. Head Neck Oncol; 2009 Dec 23;1:41
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  • [Title] Basal cell adenocarcinoma of a hard palate minor salivary gland: case report and review of the literature.
  • OBJECTIVE: Basal cell adenocarcinoma of a minor salivary gland is extremely rare.
  • The goal of this report is to increase awareness of this rare disease and to review and discuss the differential diagnosis and important considerations in treatment.
  • METHODS: Case report of a basal cell adenocarcinoma of a hard palate minor salivary gland and review of the literature of basal cell adenocarcinoma.
  • Histological diagnosis is important to distinguish this tumour from adenoid cystic carcinoma given the significant difference in disease prognosis.
  • CONCLUSIONS: Diagnosis of these tumours must be made histologically.

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  • (PMID = 20030819.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / K08 DE018061
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2806868
  • [General-notes] NLM/ Original DateCompleted: 20100629
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54. Maruyama S, Cheng J, Yamazaki M, Zhou XJ, Zhang ZY, He RG, Saku T: Metastasis-associated genes in oral squamous cell carcinoma and salivary adenoid cystic carcinoma: a differential DNA chip analysis between metastatic and nonmetastatic cell systems. Cancer Genet Cytogenet; 2010 Jan 1;196(1):14-22
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  • [Title] Metastasis-associated genes in oral squamous cell carcinoma and salivary adenoid cystic carcinoma: a differential DNA chip analysis between metastatic and nonmetastatic cell systems.
  • Overall modes of differential gene expressions were analyzed between human oral/salivary carcinoma cell systems with (MK-1 and ACCM) and without (ZK-1/ZK-2 and ACC2/ACC3) metastatic potential by using micro-array analysis with cancer-associated DNA chips to determine the kinds of genes associated with metastatic behaviors.
  • MK-1 and/or ACCM showed lower levels of gene expression in extracellular matrix-related molecules, such as collagen type IV, laminin, and adhesion molecules such as cadherin 2, but higher levels of genes which control extracellular matrix degradation, such as MMP 9, as well as cell growth and cycle, such as FGF7 and cyclin D1.
  • Among the differentially expressed genes, similar protein expression tendencies for FGF7, laminin, cyclin D1, and collagen type IV were confirmed by immunofluorescence.
  • Metastatic potentials of oral/salivary carcinoma cells seem to have resulted from certain combinations of over-/underexpression of the genes, which were responsible for extracellular matrix metabolism and cell growth in particular.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Squamous Cell / genetics. Mouth Neoplasms / genetics. Neoplasm Metastasis / genetics. Oligonucleotide Array Sequence Analysis. Salivary Gland Neoplasms / genetics


55. Yamada T, Mouri H, Izumi K, Takeuchi S, Ohtsubo K, Yamashita K, Yasumoto K, Kitamura S, Yano S: [Combined chemotherapy with cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1545-8
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  • [Title] [Combined chemotherapy with cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma].
  • We report a case of a 65-year-old man with metastatic primary cutaneous adenoid cystic carcinoma that was effectively treated by combination chemotherapy with cisplatin (CDDP) plus vinorelbine(VNR).
  • He was given a diagnosis of primary cutaneous adenoid cystic carcinoma with metastatic lesions to multiple lungs and left tibial bone and then given chemotherapy combining CDDP plus VNR as the first treatment in December 2008.
  • We reported the efficacy of combined treatment with CDDP plus VNR for primary cutaneous adenoid cystic carcinoma, because this clinical condition was very rare and the standard treatment has still not been established.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Cisplatin / therapeutic use. Lung Neoplasms / drug therapy. Skin Neoplasms / drug therapy. Vinblastine / analogs & derivatives

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  • (PMID = 20716883.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; Q6C979R91Y / vinorelbine
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56. Zeng Q, Tang PZ, Xu ZG, Qi YF, Wu XX, Liu WS: [Malignant minor salivary gland tumors of the larynx]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Jan;44(1):40-3
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  • Ten patients (66.7%) had adenoid cystic carcinoma and 2 (13.3%) had adenocarcinoma.
  • The other three patients had mucoepidermoid carcinomas, polymorphic adenocarcinoma and base cell carcinoma respectively.
  • Five patients were found to have recurrent disease, 4 of whom underwent salvage surgery, 1 of whom had palliation radiotherapy.
  • Five patients have no evidence of disease, 1 of whom had surgery alone, 4 of whom were treated with surgery plus radiotherapy.
  • Seven patients developed recurrent disease, 1 of whom had local recurrence alone, 1 had regional recurrence alone, 2 had distant metastases alone, and 3 had local and distant metastases.
  • CONCLUSIONS: Minor salivary gland carcinomas of the larynx are rare and they are prone to the local recurrence and the distant metastasis in advanced stage.

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  • (PMID = 19484987.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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57. Razak AR, Siu LL, Le Tourneau C: Molecular targeted therapies in all histologies of head and neck cancers: an update. Curr Opin Oncol; 2010 May;22(3):212-20
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  • RECENT FINDINGS: The use of cetuximab in squamous cell head and neck cancer is associated with clinical benefit and, in some cases, survival.
  • However, the use of targeted agents beyond cetuximab in this disease remains investigational.
  • Combination therapy of molecular targeted agents with chemoradiation in the locally advanced setting of head and neck squamous cell carcinomas and nasopharyngeal cancer shows early promising results, but at the expense of increased toxicity.
  • The recent identification of improved prognosis among head and neck squamous cell carcinoma patients whose tumors harbor the human papilloma virus may allow better treatment selection for these patients, while the identification of a hallmark gene fusion transcript in adenocystic carcinoma may herald new treatment promise.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / therapy. Drug Delivery Systems / methods. Head and Neck Neoplasms / therapy

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  • (PMID = 20173639.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; PQX0D8J21J / Cetuximab
  • [Number-of-references] 77
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58. Jensen AD, Krauss J, Weichert W, Debus J, Münter MW: RadioImmunotherapy for adenoid cystic carcinoma: a single-institution series of combined treatment with cetuximab. Radiat Oncol; 2010;5:102
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  • [Title] RadioImmunotherapy for adenoid cystic carcinoma: a single-institution series of combined treatment with cetuximab.
  • BACKGROUND: Local control in adjuvant/definitive RT of adenoid cystic carcinoma (ACC) is largely dose-dependent.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Carbon Radioisotopes / therapeutic use. Carcinoma, Adenoid Cystic / radiotherapy. Heavy Ions / therapeutic use. Radioimmunotherapy / methods
  • [MeSH-minor] Adult. Aged. Antibodies, Monoclonal, Humanized. Cetuximab. Combined Modality Therapy. Disease-Free Survival. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Middle Aged. Radiotherapy Planning, Computer-Assisted. Radiotherapy, Intensity-Modulated

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  • (PMID = 21047402.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Carbon Radioisotopes; PQX0D8J21J / Cetuximab
  • [Other-IDs] NLM/ PMC2987937
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59. Guo XL, Sun SZ, Wei FC: [Mechanisms of p16 gene inactivation salivary adenoid cystic carcinoma]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2005 Oct;23(5):418-20
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  • [Title] [Mechanisms of p16 gene inactivation salivary adenoid cystic carcinoma].
  • OBJECTIVE: To study the mechanism of p16 gene inactivation in salivary adenoid cystic carcinoma.
  • METHODS: 53 cases of freshly excised salivary adenoid cystic carcinomas were studied.
  • Polymerase chain reaction (PCR) and single-stranded conformation polymorphism analysis of polymerase chain reaction products (PCR-SSCP) were used to detect deletion and mutation of p16 gene in salivary adenoid cystic carcinomas.
  • RESULTS: The homozygous deletion, mutation and hypermethylation of p16 gene were noted in 16 cases (30.2%), 4 cases (7.5%) and 26 cases (49.1%) respectively in 53 cases of salivary adenoid cystic carcinomas.
  • CONCLUSION: The main inactivation mechanisms of p16 gene in salivary adenoid cystic carcinoma were hypermethylation and homozygous deletion.
  • The mutation p16 gene was rare in salivary adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic. DNA Methylation

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  • (PMID = 16285551.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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60. Lin CH, Yen RF, Jeng YM, Tzen CY, Hsu C, Hong RL: Unexpected rapid progression of metastatic adenoid cystic carcinoma during treatment with imatinib mesylate. Head Neck; 2005 Dec;27(12):1022-7
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  • [Title] Unexpected rapid progression of metastatic adenoid cystic carcinoma during treatment with imatinib mesylate.
  • BACKGROUND: There is a lack of effective treatment for metastatic adenoid cystic carcinoma (ACC), a usually indolent tumor.
  • Mutations of c-kit and platelet-derived growth factor receptor (PDGFR)-alpha in tumors from these patients were analyzed.
  • RESULTS: Disease progression was noted in three of five patients during the short treatment periods, ranging from 2 to 3 weeks.
  • Three patients died of disease within 6 months.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Carcinoma, Adenoid Cystic / drug therapy. Head and Neck Neoplasms / pathology. Lung Neoplasms / drug therapy. Piperazines / adverse effects. Pyrimidines / adverse effects
  • [MeSH-minor] Administration, Oral. Adult. Benzamides. DNA Mutational Analysis. Disease Progression. Female. Humans. Imatinib Mesylate. Male. Middle Aged. Pilot Projects. Pleural Effusion, Malignant / pathology. Protein-Tyrosine Kinases / antagonists & inhibitors

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc.
  • (PMID = 16265655.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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61. Friedrich RE: Dermal cylindroma of the scalp (turban tumour) and subjacent calvarian defects. Anticancer Res; 2010 May;30(5):1793-7
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  • [Title] Dermal cylindroma of the scalp (turban tumour) and subjacent calvarian defects.
  • This case report describes the diagnosis and therapy of a patient with a 40-year history of multiple potato-like tumours growing in the head and neck region.
  • The tumour proved to be a cylindroma, associated with calvarian defects.
  • A long lasting history of cylindroma and evidence for bone destruction, not associated with a malignant transformation, is extremely rare in Brooke-Spiegler's syndrome.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / pathology. Scalp / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Angiography / methods. Biopsy. Carotid Arteries / pathology. Female. Humans. Magnetic Resonance Imaging / methods. Skin / pathology. Syndrome. Treatment Outcome

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  • (PMID = 20592381.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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62. Messaoudi C, Larouk R, Baili S, Noui B, Benchaoui M, Benkadri H, Belbekri F: [Adenoid cystic carcinoma of the larynx. A case report and review of the literature]. Rev Laryngol Otol Rhinol (Bord); 2007;128(1-2):97-100
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  • [Title] [Adenoid cystic carcinoma of the larynx. A case report and review of the literature].
  • [Transliterated title] Carcinome adénoïde kystique du larynx. Revue de la littérature, à propos d'un cas.
  • Cylindroma of the head and neck, known as "cystic adenoid carcinoma", begins more often at the expense of the all glandular structures of ectodermic origin, in particularly at the minor and principal salivary glands.
  • RESULTS: The patient is free of disease after six months of follow up.
  • CONCLUSION: The laryngeal cylindroma is rare.
  • The symptomatology does not show a proper characteristic, the diagnosis is a histological finding, and the natural evolution is marked by the very show development of this tumour the onset of cervical lymphatic adenopathy.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 17633677.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 33
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63. Font RL, Del Valle M, Avedaño J, Longo M, Boniuk M: Primary adenoid cystic carcinoma of the conjunctiva arising from the accessory lacrimal glands: a clinicopathologic study of three cases. Cornea; 2008 May;27(4):494-7
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  • [Title] Primary adenoid cystic carcinoma of the conjunctiva arising from the accessory lacrimal glands: a clinicopathologic study of three cases.
  • PURPOSE: To report 3 cases of primary adenoid cystic carcinoma originating from the accessory and/or ectopic lacrimal glands of the conjunctiva.
  • Sections were cut at 5 microm, and the slides were stained with hematoxylin-eosin, periodic acid-Schiff, alcian blue, and colloidal iron methods.
  • RESULTS: We report 3 conjunctival tumors that histopathologically proved to be adenoid cystic carcinomas that had arisen from the accessory lacrimal glands of the conjunctiva (cases 1 and 2) and from ectopic lacrimal gland tissue (case 3).
  • Follow-up examination showed no evidence of recurrence or metastatic disease in cases 1 and 2 (10 and 8 years, respectively).
  • CONCLUSIONS: Adenoid cystic carcinoma arising from the accessory lacrimal glands of the conjunctiva is a rare occurrence.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Conjunctival Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology

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  • (PMID = 18434856.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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64. Closmann JJ, Schmidt BL: Adenoid cystic carcinoma manifesting as maxillary jaw pain refractory to conventional treatment: a case report. Gen Dent; 2006 May-Jun;54(3):195-7
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  • [Title] Adenoid cystic carcinoma manifesting as maxillary jaw pain refractory to conventional treatment: a case report.
  • Adenoid cystic carcinoma is an indolent, slow-growing tumor that may first cause low-grade pain in the affected region.
  • This article describes a case involving adenoid cystic carcinoma of the maxilla that was present for approximately nine years.
  • Prior to diagnosis, five dentists reported that the patient had anisocoria, migraine headaches, and low-to-moderate upper jaw pain that was refractory to conventional therapy.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Facial Pain / diagnosis. Maxillary Diseases / diagnosis. Maxillary Neoplasms / diagnosis
  • [MeSH-minor] Adult. Anisocoria / diagnosis. Denture Design. Denture, Partial, Temporary. Diagnosis, Differential. Female. Humans. Migraine Disorders / diagnosis. Palatal Obturators. Prosthesis Design. Radiotherapy, Adjuvant

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  • (PMID = 16776413.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Madani I, Bonte K, Vakaet L, Boterberg T, De Neve W: Intensity-modulated radiotherapy for sinonasal tumors: Ghent University Hospital update. Int J Radiat Oncol Biol Phys; 2009 Feb 1;73(2):424-32
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  • The tumor histologic type was adenocarcinoma in 54, squamous cell carcinoma in 17, esthesioneuroblastoma in 9, and adenoid cystic carcinoma in 4.
  • The 5-year local control, overall survival, disease-specific survival, disease-free survival, and freedom from distant metastasis rate was 70.7%, 58.5%, 67%, 59.3%, and 82.2%, respectively.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Hospitals, University. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / radiotherapy. Radiotherapy Dosage. Survival Rate. Treatment Outcome

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  • (PMID = 18755554.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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66. Hao L, Xiao-lin N, Qi C, Yi-ping Y, Jia-quan L, Yan-ning L: Nerve growth factor and vascular endothelial growth factor: retrospective analysis of 63 patients with salivary adenoid cystic carcinoma. Int J Oral Sci; 2010 Mar;2(1):35-44
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  • [Title] Nerve growth factor and vascular endothelial growth factor: retrospective analysis of 63 patients with salivary adenoid cystic carcinoma.
  • AIM: To detect the expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) in salivary adenoid cystic carcinoma (SACC) tissues, as well as to determine the correlation between growth factor expression and prognosis in SACC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Nerve Growth Factor / analysis. Salivary Gland Neoplasms / pathology. Vascular Endothelial Growth Factor A / analysis

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  • (PMID = 20690417.001).
  • [ISSN] 1674-2818
  • [Journal-full-title] International journal of oral science
  • [ISO-abbreviation] Int J Oral Sci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 9061-61-4 / Nerve Growth Factor
  • [Other-IDs] NLM/ PMC3475596
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67. Epivatianos A, Poulopoulos A, Dimitrakopoulos I, Andreadis D, Nomikos A, Vlahou S, Papazoglou G, Barbatis C: Application of alpha-smooth muscle actin and c-kit in the differential diagnosis of adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. Oral Oncol; 2007 Jan;43(1):67-76
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  • [Title] Application of alpha-smooth muscle actin and c-kit in the differential diagnosis of adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma.
  • The expression of vimentin, alpha-smooth muscle actin (alpha-SMA) and c-kit in adenoid cystic carcinomas (AdCCs) and polymorphous low-grade adenocarcinomas (PLGAs) was investigated immunohistochemically to evaluate the application of these markers to distinguish AdCCs from PLGAs when the histological features are equivocal.
  • The immunoreactivity of c-kit in all positive cases of AdCCs (83%) and PLGAs (41%) was more than 50% and less than 50% of tumor cells respectively.
  • The results of this study support the potential application of alpha-SMA and c-kit as an adjunctive aid in the differential diagnosis of AdCCs from PLGAs.
  • [MeSH-major] Actins / analysis. Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / diagnosis. Proto-Oncogene Proteins c-kit / analysis. Vimentin / analysis
  • [MeSH-minor] Cytoskeletal Proteins. Diagnosis, Differential. Humans. Immunohistochemistry. Muscle Proteins. Retrospective Studies

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  • (PMID = 16807072.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Muscle Proteins; 0 / Smooth muscle protein, human; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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68. Schulz-Ertner D, Nikoghosyan A, Didinger B, Münter M, Jäkel O, Karger CP, Debus J: Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques. Cancer; 2005 Jul 15;104(2):338-44
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  • [Title] Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques.
  • BACKGROUND: The authors evaluated whether modern photon techniques, such as stereotactic fractionated radiation therapy (FSRT) or intensity-modulated RT, outweighed the biologic advantages of high-linear-energy transfer RT in the treatment of patients with locally advanced adenoid cystic carcinomas (ACC) that infiltrated the skull base or the orbit.
  • Disease-free and overall survival rates at 2 years/4 years were 71.5%/53% and 86.6%/75.8% for Group A and 69.2%/23% and 77.9%/77.9% for Group B, respectively.
  • [MeSH-major] Carbon Radioisotopes / therapeutic use. Carcinoma, Adenoid Cystic / radiotherapy. Photons / therapeutic use

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  • (PMID = 15937907.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbon Radioisotopes
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69. Farrell T, Chang YL: Basal cell adenocarcinoma of minor salivary glands. Arch Pathol Lab Med; 2007 Oct;131(10):1602-4
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  • [Title] Basal cell adenocarcinoma of minor salivary glands.
  • Basal cell adenocarcinoma of minor salivary glands is a relatively rare slow-growing tumor with an infiltrating growth pattern.
  • The infiltrating growth pattern and likelihood of vascular and perineural involvement distinguishes basal cell adenocarcinoma from basal cell adenoma.
  • Other diagnostic considerations include adenoid cystic carcinoma and basaloid squamous carcinoma.
  • It is necessary to differentiate basal cell adenocarcinoma from other basaloid cell tumors of the minor salivary glands because of the prognosis and potential differences in treatment, particularly adenoid cystic adenocarcinoma and basaloid squamous carcinoma.
  • Surgical excision with a wide margin to ensure complete removal has been suggested as the primary treatment for basal cell adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Squamous Cell / diagnosis. Combined Modality Therapy. Diagnosis, Differential. Humans

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  • (PMID = 17922602.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Miyamoto J, Tatsuzawa K, Owada K, Kawabe T, Sasajima H, Mineura K: Usefulness and limitations of fluorine-18-fluorodeoxyglucose positron emission tomography for the detection of malignancy of orbital tumors. Neurol Med Chir (Tokyo); 2008;48(11):495-9; discussion 499
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  • Histological examination identified 7 lesions as malignant: anaplastic astrocytoma of the optic nerve in 1 patient, which recurred as glioblastoma of the optic nerve, malignant lymphoma of mucosa-associated lymphoid tissue type in 1 patient, malignant melanoma in 1 patient, adenoid cystic carcinoma in 2 patients, and adenocarcinoma (unknown origin) in 1 patient.
  • [18F]FDG PET can determine the malignancy of orbital tumors, but cannot distinguish malignant tumor from inflammatory disease such as pseudotumor.
  • [MeSH-minor] Adenocarcinoma / radionuclide imaging. Adolescent. Adult. Aged. Astrocytoma / radionuclide imaging. Carcinoma, Adenoid Cystic / radionuclide imaging. Diagnosis, Differential. Female. Fluorine Radioisotopes. Fluorodeoxyglucose F18. Glioblastoma / radionuclide imaging. Hemangioma, Cavernous, Central Nervous System / radionuclide imaging. Humans. Lymphoma, B-Cell, Marginal Zone / radionuclide imaging. Male. Melanoma / radionuclide imaging. Middle Aged. Neurilemmoma / radionuclide imaging. Orbital Pseudotumor / radionuclide imaging. Radiopharmaceuticals. Young Adult

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  • (PMID = 19029776.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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71. Maiuri F, Gangemi M, Giamundo A, Mariniello G, Colella A, Vergara P, Del Basso De Caro ML: Intracranial extension of salivary gland tumors. Clin Neuropathol; 2010 Jan-Feb;29(1):9-13
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  • The primary tumors were an adenocarcinoma and a malignant oncocytoma of the parotid gland and an adenoid cystic carcinoma of the submandibular gland.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Brain Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 20040327.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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72. Shi H, Wang J, Dong FS, Wang X, Li HX: [Relationship between proteoglycans and proliferation of human salivary adencid cystic carcinoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2010 Jan;45(1):20-5
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  • [Title] [Relationship between proteoglycans and proliferation of human salivary adencid cystic carcinoma].
  • OBJECTIVE: To investigate the effect of down-regulated proteoglycans on the proliferation of human salivary adenoid cystic carcinoma (SACC).
  • Adenoid cystic carcinoma cells with high metastatic tendency (ACC-M) were transfected by shRNA-WJ3.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Cell Proliferation. Pentosyltransferases / metabolism. Proteoglycans / metabolism. Salivary Gland Neoplasms / pathology

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  • (PMID = 20368035.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Proteoglycans; 0 / RNA, Messenger; 0 / RNA, Small Interfering; EC 2.4.2.- / Pentosyltransferases; EC 2.4.2.26 / UDP xylose-protein xylosyltransferase
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73. Zhang Y, Liu J, Xue F, Li J: p16 tumor suppressor therapy in salivary adenoid cystic carcinoma cell line SACC83. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Jul;100(1):70-4
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  • [Title] p16 tumor suppressor therapy in salivary adenoid cystic carcinoma cell line SACC83.
  • OBJECTIVE: This study aimed to determine the growth inhibitory effects of transfecting the wild-type p16 gene into human salivary adenoid cystic carcinoma (SACC) cells in vitro.
  • METHODS: p16 cDNA was cloned into pDOR-neo plasmid by recombination technique, and the human eukaryotic expression vector, pDOR-p16 , was constructed.
  • CONCLUSION: The study confirmed the reversal effect of wild-type p16 on malignant phenotype of the salivary adenoid cystic carcinoma and provides valuable data for further clinical trial of gene therapy with p16.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Genes, p16 / physiology. Genetic Therapy. Salivary Gland Neoplasms / therapy

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  • (PMID = 15953919.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Tetrazolium Salts; 0 / Thiazoles; 298-93-1 / thiazolyl blue; 9007-49-2 / DNA
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74. Nomoto S, Shioyama Y, Ohga S, Nonoshita T, Ohnishi K, Atsumi K, Terashima K, Nakashima T, Nakamura K, Hirata H, Honda H: Preliminary results of radiation therapy for locally advanced or recurrent adenoid cystic carcinomas of the head and neck using combined conventional radiation therapy and hypofractionated inverse planned stereotactic radiation therapy. Fukuoka Igaku Zasshi; 2009 Feb;100(2):59-66
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  • [Title] Preliminary results of radiation therapy for locally advanced or recurrent adenoid cystic carcinomas of the head and neck using combined conventional radiation therapy and hypofractionated inverse planned stereotactic radiation therapy.
  • PURPOSE: To investigate the clinical outcomes and feasibility of combined conventional radiation therapy (RT) and hypofractionated inverse planned stereotactic radiation therapy (SRT) for locally advanced or recurrent adenoid cystic carcinomas (ACCs) of the head and neck.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Dose Fractionation. Head and Neck Neoplasms / radiotherapy. Radiosurgery

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  • (PMID = 19455976.001).
  • [ISSN] 0016-254X
  • [Journal-full-title] Fukuoka igaku zasshi = Hukuoka acta medica
  • [ISO-abbreviation] Fukuoka Igaku Zasshi
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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75. Soysal HG: Orbital exenteration: a 10-year experience of a general oncology hospital. Orbit; 2010 Jun;29(3):135-9
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  • [Title] Orbital exenteration: a 10-year experience of a general oncology hospital.
  • The age, sex, the location of tumour, the duration of symptoms, histopathological diagnosis, and previous recurrences were noted.
  • Seven different types of histopathology were encountered: squamous cell carcinoma (31 cases), basal cell carcinoma (26 cases), malignant melanoma (5 cases), sebaceous cell carcinoma (2 cases), rhabdomyosarcoma (2 cases), mucoepidermoid carcinoma (1 case) and adenoid cystic carcinoma (1 case).
  • CONCLUSIONS: Large proportion of the patients that underwent exenteration had a history of previous unsuccessful treatment and a long duration of disease.

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  • (PMID = 20497078.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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76. Liang S, Fan M: Immunotherapy for adenoid cystic carcinoma of salivary glands: cancer/testis antigens and 5-aza-2'-deoxycytidine. Med Hypotheses; 2009 Nov;73(5):768-9
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  • [Title] Immunotherapy for adenoid cystic carcinoma of salivary glands: cancer/testis antigens and 5-aza-2'-deoxycytidine.
  • Adenoid cystic carcinoma of salivary glands is the epithelial tumor.
  • There are amount of malignant occurrences of adenoid cystic carcinoma of salivary glands in the head and neck area.
  • Cancer/testis antigens can be found in various malignant tumors, normal adult testis and occasionally placenta, but not in the other normal adult tissues.
  • This characteristic makes Cancer/testis antigens as potential markers to be applied in immunotherapeutic strategies against cancer.
  • It has been shown that in different tumors, the expression of certain Cancer/testis antigens is activated treated with 5-aza-CdR via the demethylation of their promoter CpG islands.
  • It is logical that multiple Cancer/testis antigens may correlate with the clinicopathologic factors of adenoid cystic carcinoma of salivary glands and be the potential markers of prognosis treated with 5-aza-CdR.
  • So the hypothesis will provide the new direction that we can use Cancer/testis antigens as candidate antigens for adenoid cystic carcinoma of salivary glands immunotherapy due to the high expression rate activated with 5-aza-CdR.
  • [MeSH-major] Antigens, Neoplasm / immunology. Carcinoma, Adenoid Cystic / therapy. Immunotherapy. Salivary Gland Neoplasms / therapy. Testis / immunology

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  • (PMID = 19481355.001).
  • [ISSN] 1532-2777
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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77. Jaeger RG, Scarabotto-Neto N, Azambuja N Jr, Freitas VM: Secretion of collagen I and tenascin is modulated by laminin-111 in 3D culture of human adenoid cystic carcinoma cells. Int J Exp Pathol; 2008 Apr;89(2):98-105
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  • [Title] Secretion of collagen I and tenascin is modulated by laminin-111 in 3D culture of human adenoid cystic carcinoma cells.
  • Adenoid cystic carcinoma is a frequent malignant salivary gland neoplasm with high levels of recurrence and metastasis.
  • We are studying regulatory mechanisms underlying secretion of ECM molecules in adenoid cystic carcinoma.
  • We have previously demonstrated that laminin modulates the phenotype of a human adenoid cystic carcinoma (CAC2) cell line.
  • We suggest that laminin-111 modulates secretion of collagen I and tenascin in cells derived from human adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secretion. Collagen Type I / secretion. Laminin / pharmacology. Neoplasm Proteins / secretion. Tenascin / secretion

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  • (PMID = 18336527.001).
  • [ISSN] 1365-2613
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Gels; 0 / Laminin; 0 / Neoplasm Proteins; 0 / Tenascin; 0 / laminin 1
  • [Other-IDs] NLM/ PMC2525767
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78. Otoh EC, Johnson NW, Olasoji HO, Danfillo IS, Adeleke OA: Intra-oral carcinomas in Maiduguri, north-eastern Nigeria. Oral Dis; 2005 Nov;11(6):379-85
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  • [Title] Intra-oral carcinomas in Maiduguri, north-eastern Nigeria.
  • OBJECTIVE: To document the pattern of intra-oral carcinomas diagnosed in north-eastern Nigeria.
  • MATERIALS AND METHODS: Information on socio-demographic characteristics of patients and details of cancer management were retrieved from the files and histopathology records of cases diagnosed at the hospital.
  • RESULTS: A total of 378 biopsies, 317 primary cancers including 279 carcinomas of the head and neck were diagnosed during the study period.
  • Intra-oral carcinomas constitute 43 (15.4%) of all head and neck carcinomas reported, with no occurrence in children.
  • Carcinomas were commonly reported in the palate 19 (44.2%) and lip six (13.9%) and floor of mouth four (9.3%).
  • Squamous cell carcinoma 28 (65.1%), adenoidcystic carcinoma seven (16.3%) and mucoepidermoid carcinoma five (11.6%) were the commonly reported carcinomas.
  • Squamous cell carcinoma was the most common carcinoma in all sites, in the sixth decade of life, of equal gender distribution and commonly reported in users of kola nuts and tobacco.
  • The occupation of patients diagnosed with oral carcinoma and squamous cell carcinoma was farming (50%, 61.5%).
  • All the staged cancers patients (n = 7) reported in the late stages (III/IV) of the disease.
  • The mean interval between symptoms and presentation for the different carcinomas ranged between 9 and 25 months, with the least interval reported for mucoepidermoid carcinoma.
  • CONCLUSIONS: Squamous cell carcinoma was the most common oral carcinoma, commonly reported in the palate, among farmers and in the sixth decade of life.
  • The survival rates of patients diagnosed with intra-oral carcinomas, although not available, would be expectedly low in view of the prognostic indicators recorded in this series.
  • The routine oral cancer screening of each patient, and counselling of patients with high-risk habits, by dentists is recommended to improve the prognosis of the disease.
  • [MeSH-major] Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Squamous Cell / epidemiology. Mouth Neoplasms / epidemiology

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  • (PMID = 16269030.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Number-of-references] 38
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79. Chen F, Sonobe M, Sato K, Fujinaga T, Shoji T, Sakai H, Miyahara R, Bando T, Okubo K, Hirata T, Date H: Pulmonary resection for metastatic head and neck cancer. World J Surg; 2008 Aug;32(8):1657-62
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  • [Title] Pulmonary resection for metastatic head and neck cancer.
  • Various perioperative variables were investigated retrospectively to analyze the prognostic factors for overall survival and disease-free survival after metastasectomy.
  • RESULTS: Of the 20 patients, 10 (50%) had squamous cell carcinoma, 7 (35%) had adenoid cystic carcinoma, and 3 had miscellaneous carcinomas.
  • The median disease-free interval from the time of treatment of the head and neck primary cancers to the development of pulmonary metastases was 27 months.
  • Disease-free survival rate was 25.0% at 5 years after pulmonary resection.
  • A disease-free interval equal to or longer than 12 months was a significantly favorable prognostic factor for both overall survival and disease-free survival (p = 0.02 and 0.01, respectively).
  • Patients with squamous cell carcinoma and male sex showed a worse overall survival (p = 0.04 and 0.03, respectively).
  • A disease-free interval equal to or longer than 12 months, nonsquamous cell carcinoma, and female sex might be relevant to a better prognosis.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Head and Neck Neoplasms / pathology. Lung Neoplasms / secondary. Lung Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • [Cites] Semin Oncol. 2007 Jun;34(3):186-96 [17560980.001]
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  • (PMID = 18553194.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Oliai BR, Sheth S, Burroughs FH, Ali SZ: "Parapharyngeal space" tumors: a cytopathological study of 24 cases on fine-needle aspiration. Diagn Cytopathol; 2005 Jan;32(1):11-5
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  • Of the 18 cases considered diagnostic, there were nine (50%) pleomorphic adenomas (PAs); three (17%) squamous-cell carcinomas (SCC); and one each of oncocytoma, adenocarcinoma, not otherwise specified (NOS), adenoid cystic carcinoma, lipoma, neurofibroma, and non-Hodgkin lymphoma, together comprising the remaining 33%.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Biopsy, Fine-Needle / methods. Carcinoma, Squamous Cell / pathology. Pharyngeal Neoplasms / pathology. Pharynx / pathology

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • [CommentIn] Diagn Cytopathol. 2006 Jan;34(1):82-3 [16355379.001]
  • (PMID = 15584054.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Dodd RL, Slevin NJ: Salivary gland adenoid cystic carcinoma: a review of chemotherapy and molecular therapies. Oral Oncol; 2006 Sep;42(8):759-69
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  • [Title] Salivary gland adenoid cystic carcinoma: a review of chemotherapy and molecular therapies.
  • Adenoid cystic carcinoma (ACC) accounts for about 1% of all head and neck malignancies.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Salivary Gland Neoplasms / drug therapy


82. Otsuka H, Graham MM, Kogame M, Nishitani H: The impact of FDG-PET in the management of patients with salivary gland malignancy. Ann Nucl Med; 2005 Dec;19(8):691-4
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  • Histology consisted of 8 adenocarcinomas, 8 squamous cell carcinomas, 4 adenoid cystic carcinomas, 4 carcinoma ex pleomorphic adenomas, 2 mucoepidermoid carcinomas, 2 poorly differentiated carcinomas, 1 salivary duct carcinoma, 1 lymphoepithelial carcinoma and 1 melanoma.
  • RESULTS: In the initial staging group, all 12 primary lesions (100%) showed positive FDG uptake (5 squamous cell carcinomas, 2 adenocarcinomas, 2 poorly differentiated carcinomas, 1 carcinoma ex pleomorphic adenoma, 1 salivary duct carcinoma, 1 lymphoepithelial carcinoma).
  • Three patients (25%) had FDG positive distant disease (liver, bone, lymph nodes); surgery was canceled and therapy changed to chemoradiation.
  • In the restaging group (33 studies in 23 patients), 5 patients (22%) had FDG positive distant disease, which changed the treatment from surgery to chemoradiation or other.

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  • (PMID = 16444995.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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83. Li J, El-Naggar A, Mao L: Promoter methylation of p16INK4a, RASSF1A, and DAPK is frequent in salivary adenoid cystic carcinoma. Cancer; 2005 Aug 15;104(4):771-6
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  • [Title] Promoter methylation of p16INK4a, RASSF1A, and DAPK is frequent in salivary adenoid cystic carcinoma.
  • However, little is known about its role in the development of adenoid cystic carcinoma of the salivary gland (ACC).
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Genes, Tumor Suppressor. Methylation. Promoter Regions, Genetic. Salivary Gland Neoplasms / genetics

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  • (PMID = 15959912.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01 CA106451
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / RASSF1 protein, human; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / Death-Associated Protein Kinases; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases
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84. Li Z, Cen Y, Yang K: [Modified transcranial approach to resect tumor around the anterior skull base and double tissue flap to reconstruct the anterior skull base]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2006 Sep;20(9):896-8
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  • METHODS: In November 2004, a 49-years-old male patient with intracranial recrudescent adenoid cystic carcinoma in the anterior cranial fossa was treated using modified transcranial approach.

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  • (PMID = 17036975.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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85. Bi YW, Chen RJ: [Clinical and pathological analysis of 151 cases of tumors in lacrimal fossa]. Zhonghua Yan Ke Za Zhi; 2005 Oct;41(10):877-81
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  • RESULTS: In 69 cases of benign lacrimal epithelial tumors, pleomorphic adenoma was the most common tumor (63 cases, 41.7%), followed by myoepithelioma (3 cases, 1.2%), lacrimal duct cyst (2 cases, 1.3%).
  • In 34 cases of malignant lacrimal epithelial tumors, adenoid cystic carcinoma was the most common tumor (15 cases, 9.9%), followed by pleomorphic adenocarcinoma (14 cases, 9.3%), adenocarcinoma (4 cases, 2.6%).
  • The treatment of pleomorphic adenoma and the diagnosis of MALT lymphoma are the most difficult tasks in present clinical work.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lacrimal Apparatus Diseases / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Orbital Neoplasms / pathology

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  • (PMID = 16271170.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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86. Bellizzi AM, Woodford RL, Moskaluk CA, Jones DR, Kozower BD, Stelow EB: Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers. Am J Surg Pathol; 2009 Nov;33(11):1608-14
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  • [Title] Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers.
  • Basaloid squamous cell carcinoma (BSCC) of the esophagus is rare, historically confused for adenoid cystic carcinoma, and recently shown to behave similar to conventional, keratinizing esophageal squamous cell carcinoma.
  • HPVs role in esophageal squamous cell carcinomas is less certain, and to our knowledge, a direct examination of esophageal BSCC for high-risk HPV has not been performed earlier.
  • Twenty-two cases of keratinizing esophageal squamous cell carcinoma served as controls.
  • Differential p16 and p53 expression in BSCC suggests that these tumors are molecularly distinct from conventional esophageal squamous cell carcinomas.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Carcinoma, Basal Cell / virology. Carcinoma, Basosquamous / virology. Carcinoma, Squamous Cell / virology. Esophageal Neoplasms / virology. Papillomavirus Infections / complications


87. Hentschel SJ, Vora Y, Suki D, Hanna EY, DeMonte F: Malignant tumors of the anterolateral skull base. Neurosurgery; 2010 Jan;66(1):102-12; discussion 112
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  • The most frequently occurring pathologies after the various sarcomas were squamous cell carcinoma (SCC) and adenoid cystic carcinoma (ACC) in 23% and 14% of patients, respectively.


88. Brandt SM, Swistel AJ, Rosen PP: Secretory carcinoma in the axilla: probable origin from axillary skin appendage glands in a young girl. Am J Surg Pathol; 2009 Jun;33(6):950-3
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  • [Title] Secretory carcinoma in the axilla: probable origin from axillary skin appendage glands in a young girl.
  • Invasive carcinoma in the axilla may arise from skin appendage glands or ectopic breast tissue or it may be a metastasis.
  • Carcinomas of the skin adnexal glands and breast can be difficult to distinguish from each other as they often display the same patterns of growth.
  • Tubular, cribriform, papillary, apocrine, mucinous, and adenoid cystic are histologic types of carcinoma seen in the breast and skin appendage glands.
  • To our knowledge, secretory carcinoma, the most common form of mammary carcinoma in children, has not yet been described as a morphologic pattern of skin adnexal carcinoma, although we cannot exclude the possibility that such a case was reported with a different diagnosis.
  • We report a case of a young girl with secretory carcinoma that seems to have arisen from skin appendage glands in the skin of the axilla in the absence of demonstrable ectopic breast tissue.
  • [MeSH-major] Axilla / pathology. Carcinoma, Skin Appendage / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Am J Surg Pathol. 2010 Aug;34(8):1226-7; author reply 1228 [20631609.001]
  • (PMID = 19342945.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Korkontzelos I, Fragkoulidis M, Stavroulis A, Apostolikas N, Terzakis E: Adenoid cystic carcinoma of the Bartholin's gland in a young patient: eight-year follow-up. Eur J Gynaecol Oncol; 2009;30(6):686-8
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  • [Title] Adenoid cystic carcinoma of the Bartholin's gland in a young patient: eight-year follow-up.
  • Adenoid cystic carcinoma (ACC) of the Bartholin's gland is one of the rarest neoplasms of the female genital tract.
  • We report a case of a 36-year-old woman who presented at our hospital after excision of the right Bartholin gland elsewhere which proved to be ACC.
  • Our patient underwent surgical treatment only (hemivulvectomy and lymph node dissection) without radiotherapy and is free of disease eight years after.
  • [MeSH-major] Bartholin's Glands / pathology. Carcinoma, Adenoid Cystic / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 20099506.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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90. Kupferman ME, de la Garza GO, Santillan AA, Williams MD, Varghese BT, Huh W, Roberts D, Weber RS: Outcomes of pediatric patients with malignancies of the major salivary glands. Ann Surg Oncol; 2010 Dec;17(12):3301-7
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  • MATERIALS AND METHOD: This study was a retrospective case review set at a tertiary referral cancer center.
  • Patients less than 19 years of age with a diagnosis of a major salivary gland malignancy were identified at the M. D.
  • The majority of tumors arose in the parotid gland (83%), and the most common pathology was mucoepidermoid carcinoma (46%).
  • Lymphatic metastasis was identified in 37% of patients, nearly all with mucoepidermoid carcinoma.
  • CONCLUSIONS: Survival of pediatric patients with major salivary gland carcinomas is favorable.
  • Radiation therapy is beneficial for locoregional control of disease, with acceptable long-term treatment sequelae, and without a significant risk for developing second primary tumors.
  • [MeSH-major] Adenocarcinoma / therapy. Carcinoma, Adenoid Cystic / therapy. Carcinoma, Mucoepidermoid / therapy. Carcinoma, Squamous Cell / therapy. Salivary Gland Neoplasms / therapy

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  • (PMID = 20585877.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Adamski H, Le Lan J, Chevrier S, Cribier B, Watier E, Chevrant-Breton J: Primary cutaneous cribriform carcinoma: a rare apocrine tumour. J Cutan Pathol; 2005 Sep;32(8):577-80
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  • [Title] Primary cutaneous cribriform carcinoma: a rare apocrine tumour.
  • BACKGROUND: Primary cutaneous cribriform carcinoma (PCCC) is a rare apocrine tumour occurring in middle-aged people.
  • The histopathological diagnosis is difficult, mainly because this tumour is exceptional.
  • Differential diagnoses, including cutaneous metastasis of adenocarcinoma, adenoid basal cell carcinoma and adenoid cystic carcinoma, are discussed.
  • [MeSH-major] Adenocarcinoma / pathology. Apocrine Glands / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Humans. Male. Treatment Outcome

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  • (PMID = 16115058.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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92. Benchetritt M, Butori C, Long E, Ilie M, Ferrari E, Hofman P: Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: diagnostic cytopathology from an exfoliative sample. Diagn Cytopathol; 2008 May;36(5):351-4
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  • [Title] Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: diagnostic cytopathology from an exfoliative sample.
  • Adenoid cystic carcinoma (ACC) occurs not only as a tumor of salivary glands, but also in very unusual locations, such as in the skin.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Heart Neoplasms / secondary. Pericardial Effusion / pathology. Pericardium / pathology. Skin Neoplasms / pathology


93. Wang L, Sun M, Jiang Y, Yang L, Lei D, Lu C, Zhao Y, Zhang P, Yang Y, Li J: Nerve growth factor and tyrosine kinase A in human salivary adenoid cystic carcinoma: expression patterns and effects on in vitro invasive behavior. J Oral Maxillofac Surg; 2006 Apr;64(4):636-41
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  • [Title] Nerve growth factor and tyrosine kinase A in human salivary adenoid cystic carcinoma: expression patterns and effects on in vitro invasive behavior.
  • PURPOSE: Perineural invasion is a frequent occurrence in salivary adenoid cystic carcinoma (ACC) and may prevent complete surgical resection.
  • The present study was conducted to investigate the expression of NGF and TrkA in salivary ACC and to examine the effects of NGF on adhesion, migration and invasion capacities of a salivary ACC cell line (SACC-83) in vitro.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Nerve Growth Factor / biosynthesis. Peripheral Nervous System Neoplasms / secondary. Receptor, trkA / biosynthesis. Salivary Gland Neoplasms / metabolism

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  • (PMID = 16546643.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9061-61-4 / Nerve Growth Factor; EC 2.7.10.1 / Receptor, trkA
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94. El Ayoubi A, Poizat F, Garrel R, Costes V, Guerrier B, Essakalli L, Kzadri M, Crampette L: [Sinonasal adenocarcinomas reviewed. Prognostic value of WHO 2005 histological classification]. Ann Otolaryngol Chir Cervicofac; 2009 Sep;126(4):175-81
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  • [Transliterated title] Les adénocarcinomes nasosinusiens revisités. Intérêt pronostique de la classification histologique OMS 2005.
  • OBJECTIVES: The WHO 2005 histological classification separates sinonasal adenocarcinoma (ADC) into three classes: intestinal-type adenocarcinoma (ITAC), low-grade sinonasal ADC and high-grade sinonasal ADC.
  • Each case was reviewed for anatomical and pathological data based on the immunohistochemistry results according to the WHO 2005 classification, with a study of a panel of markers: cytokeratin 7 (CK7), cytokeratin 20 (CK20), Villin, CDX2 and EGFR.
  • Twelve patients were reclassified into the adenoid cystic carcinoma category and excluded from the study.
  • In the 50 remaining cases, there were 36 ITAC cases, four low-grade ADC cases and 10 high-grade dedifferentiated carcinomas.
  • [MeSH-major] Adenocarcinoma / classification. Adenocarcinoma / pathology. Ethmoid Sinus. Nose Neoplasms / classification. Nose Neoplasms / pathology. Paranasal Sinus Neoplasms / classification. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Disease Progression. Female. Homeodomain Proteins / analysis. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Keratin-20 / analysis. Keratin-7 / analysis. Male. Microfilament Proteins / analysis. Middle Aged. Prognosis. Receptor, Epidermal Growth Factor / analysis. Retrospective Studies. Trans-Activators / analysis. World Health Organization

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  • (PMID = 19591973.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Keratin-7; 0 / Microfilament Proteins; 0 / Trans-Activators; 0 / villin; 156560-97-3 / Cdx-2-3 protein; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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95. Ito FA, Ito K, Coletta RD, Vargas PA, Lopes MA: Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors. Braz Oral Res; 2009 Oct-Dec;23(4):393-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands.
  • A total of 41 pleomorphic adenomas, 30 Warthin's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed.
  • Androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma.
  • In conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Neoplasms, Complex and Mixed / pathology. Receptors, Androgen / analysis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis. Salivary Gland Neoplasms / pathology

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  • (PMID = 20027446.001).
  • [ISSN] 1807-3107
  • [Journal-full-title] Brazilian oral research
  • [ISO-abbreviation] Braz Oral Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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96. Gaissert HA, Mark EJ: Tracheobronchial gland tumors. Cancer Control; 2006 Oct;13(4):286-94
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  • Bronchial gland tumors demonstrate oncologic diversity and include benign, low-grade, and high-grade malignant tumors.
  • METHODS: We reviewed the present knowledge of bronchial gland tumors of the trachea, carina, and bronchi, including the epidemiology, presentation, evaluation, tumor types, and treatment options.
  • RESULTS: The malignant bronchial gland tumors, adenoid cystic carcinoma and mucoepidermoid carcinoma, are far more common than benign mucinous cystadenoma or pleomorphic adenoma.
  • The disease-free survival after resection of malignant tumors is limited by distant metastasis and regional disease, while local recurrence is uncommon.
  • [MeSH-major] Bronchial Neoplasms. Neoplasms, Glandular and Epithelial. Tracheal Neoplasms

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  • (PMID = 17075566.001).
  • [ISSN] 1073-2748
  • [Journal-full-title] Cancer control : journal of the Moffitt Cancer Center
  • [ISO-abbreviation] Cancer Control
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 49
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97. Kara MI, Göze F, Ezirganli S, Polat S, Muderris S, Elagoz S: Neoplasms of the salivary glands in a Turkish adult population. Med Oral Patol Oral Cir Bucal; 2010 Nov;15(6):e880-5
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  • STUDY DESIGN: The histological diagnosis records of the Department of Pathology at Cumhuriyet University were reevaluated for 125 patients who were treated for salivary gland tumors from 1987 to 2008.
  • The neoplasms were analyzed for histological diagnosis, age, sex, and site.
  • Pleomorphic adenoma was the most frequent benign tumor followed by Warthin's tumor.
  • Among the malignant group, adenoid cystic carcinoma was the most prevalent.
  • CONCLUSIONS: Although there were some discrepancies, the characteristics of salivary gland tumors of Turkish patients are in line with those of patients from other countries according to tumor type, tumor site distribution, and age and sex of patients.

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  • (PMID = 20526249.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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98. Chen AM, Garcia J, Lee NY, Bucci MK, Eisele DW: Patterns of nodal relapse after surgery and postoperative radiation therapy for carcinomas of the major and minor salivary glands: what is the role of elective neck irradiation? Int J Radiat Oncol Biol Phys; 2007 Mar 15;67(4):988-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patterns of nodal relapse after surgery and postoperative radiation therapy for carcinomas of the major and minor salivary glands: what is the role of elective neck irradiation?
  • PURPOSE: To evaluate the incidence of nodal relapses from carcinomas of the salivary glands among patients with clinically negative necks in an attempt to determine the potential utility of elective neck irradiation (ENI).
  • METHODS AND MATERIALS: Between 1960 and 2004, 251 patients with clinically N0 carcinomas of the salivary glands were treated with surgery and postoperative radiation therapy.
  • Histology was: adenoid cystic (84 patients), mucoepidermoid (60 patients), adenocarcinoma (58 patients), acinic cell (21 patients), undifferentiated (11 patients), carcinoma ex pleomorphic adenoma (7 patients), squamous cell (7 patients), and salivary duct carcinoma (3 patients); 131 patients (52%) had ENI.
  • The 10-year actuarial rates of nodal failure were 7%, 5%, 12%, and 16%, for patients with T1, T2, T3, and T4 disease, respectively (p = 0.11).
  • The highest crude rates of nodal relapse among those treated without ENI were found in patients with squamous cell carcinoma (67%), undifferentiated carcinoma (50%), adenocarcinoma (34%), and mucoepidermoid carcinoma (29%).
  • There were no nodal failures observed among patients with adenoid cystic or acinic cell histology.
  • [MeSH-major] Carcinoma / secondary. Lymphatic Irradiation. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 17234357.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Adachi M, Iwai H, Yagi M, Minamino M, Omae M, Lee S, Yamashita T: [Clinical study of adenoid cystic carcinoma of the parotid gland]. Nihon Jibiinkoka Gakkai Kaiho; 2007 May;110(5):410-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical study of adenoid cystic carcinoma of the parotid gland].
  • We report results of a retrospective study of 12 cases of adenoid cystic carcinoma (ACC) in the parotid gland.
  • Although fine-needle aspiration cytology (FNA) was not effective for preoperative diagnosis, frozen section diagnosis (FS) during surgery showed excellent results.
  • Postoperative radiation therapy seemed useful in these cases and the 5-and 10-year disease-specific survivals in these 12 cases were 90.0% and 80.8%.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Parotid Neoplasms / therapy

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  • (PMID = 17564131.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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100. Ali TZ, Epstein JI: Basal cell carcinoma of the prostate: a clinicopathologic study of 29 cases. Am J Surg Pathol; 2007 May;31(5):697-705
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma of the prostate: a clinicopathologic study of 29 cases.
  • We studied 29 cases of basal cell carcinoma of the prostate including what others call adenoid cystic carcinoma of the prostate.
  • The most common methods of diagnosis was transurethral resection (TURP) (n=29) and needle biopsy (n=9).
  • In 28/29 cases, slides were reviewed and 24 (86%) cases showed more than 1 pattern: adenoid cysticlike (AC-P) pattern and small solid nests with peripheral palisading were the most predominant patterns, each seen in 18 cases (64%).
  • Perineural and vascular invasion was seen in 2 basal cell carcinomas with large basaloid nests.
  • Ki67 > or =20% was seen in 13 (56.5%) cases, including all patterns except small solid nests.
  • Seven patients had RP with: 5/7 showing extraprostatic extension with 1/5 also showing seminal vesicle involvement and 2/5 also with a positive margin; 1/7 having organ confined disease; and 1/7 showing no residual disease.
  • Of 19 (77%) cases, 14 had no evidence of disease after 1 to 19 (mean 5.8) years.
  • Basal cell carcinomas are rare tumors with a broad morphologic spectrum.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 17460452.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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