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1. Vila L, Liu H, Al-Quran SZ, Coco DP, Dong HJ, Liu C: Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland. Mod Pathol; 2009 Oct;22(10):1296-302
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  • [Title] Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.
  • The CD117 (KIT) protein is overexpressed in many human neoplasms including adenoid cystic carcinoma of salivary glands.
  • To evaluate the function of c-kit-activating mutations in adenoid cystic carcinoma of the salivary gland, we studied 14 cases (13 primary, 1 cervical lymph node metastasis) from our institution.
  • Mutational analyses of c-kit extracellular (exon 9), juxtamembrane (exon 11) and tyrosine kinase domains (exons 13 and 17) were performed by polymerase chain reaction, clonal selection and DNA sequencing.
  • This study is the first to report c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.
  • Identification of such potential gain-of-function mutations in exon 11, and less frequently in exons 9, 13 and 17, suggests that KIT may be involved in the pathogenesis of adenoid cystic carcinoma of salivary glands.
  • Our study raises a prospect of correlation of c-kit mutation and a potential treatment of adenoid cystic carcinoma with tyrosine kinase inhibitor (imatinib).

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  • [CommentIn] Mod Pathol. 2010 Jun;23(6):905-6; author reply 906-7 [20514080.001]
  • (PMID = 19617878.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK002958; United States / NIDDK NIH HHS / DK / DK02958
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Other-IDs] NLM/ NIHMS490200; NLM/ PMC3746033
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2. Ahmed MM, Abo-Hager EA: Differential expression of c-kit and CD43 in histological subtypes of adenoid cystic carcinoma of salivary gland. Saudi Dent J; 2010 Jan;22(1):27-34

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  • [Title] Differential expression of c-kit and CD43 in histological subtypes of adenoid cystic carcinoma of salivary gland.
  • Adenoid cystic carcinoma (ACC) of the salivary gland is characterized by a prolonged but inevitably unfavorable clinical course.
  • CD43 appears to be preferentially expressed in salivary gland ACCs.
  • Its expression decreased with cellular dedifferentiation and there was an inverse relationship between immunoexpression of c-kit and CD43 among ACC of salivary gland.

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  • (PMID = 23960476.001).
  • [ISSN] 1013-9052
  • [Journal-full-title] The Saudi dental journal
  • [ISO-abbreviation] Saudi Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3723079
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma (ACC) / CD43 / Immunohistochemistry / Salivary gland / c-kit
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3. Tincani AJ, Del Negro A, Araújo PP, Akashi HK, Martins AS, Altemani AM, Barreto G: Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series. Sao Paulo Med J; 2006 Jan 5;124(1):26-30
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  • [Title] Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series.
  • CONTEXT AND OBJECTIVE: Salivary gland tumor management requires long-term follow-up because of tumor indolence and possible late recurrence and distant metastasis.
  • Adenoid cystic carcinoma (ACC) accounts for 10-15% of such tumors.
  • DESIGN AND SETTING: Retrospective study at Head and Neck Service, Universidade Estadual de Campinas.
  • Major salivary gland tumor extent was routinely assessed by preoperative ultrasonography.
  • Diagnosis, surgery type, margin type (negative/positive), postoperative radiotherapy and recurrence (presence/absence) were evaluated.
  • RESULTS: There were eleven major salivary gland tumors (52.3%), seven submandibular and four parotid.
  • Ten patients (47.7%) had minor salivary gland ACC (all in palate), while the submandibular was the most frequently affected major one.
  • CONCLUSION: Adenoid cystic carcinoma has locally aggressive behavior.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 16612459.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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4. Ramer N, Wu H, Sabo E, Ramer Y, Emanuel P, Orta L, Burstein DE: Prognostic value of quantitative p63 immunostaining in adenoid cystic carcinoma of salivary gland assessed by computerized image analysis. Cancer; 2010 Jan 1;116(1):77-83
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  • [Title] Prognostic value of quantitative p63 immunostaining in adenoid cystic carcinoma of salivary gland assessed by computerized image analysis.
  • BACKGROUND: In a long-term retrospective immunohistochemical study of adenoid cystic carcinoma (ACC) of salivary gland, we investigated the relation of p63 immunodetection to prognosis.
  • CONCLUSIONS: To our knowledge, the present study is the first to report prognostic significance of p63 in salivary gland ACC and the first report of a robust and well-studied immunohistochemical stain performable on routinely fixed and processed tissue with prognostic utility.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / diagnosis. Membrane Proteins / analysis. Salivary Gland Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 American Cancer Society.
  • (PMID = 19877114.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins
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5. Dincer N, Tezel GG, Sungur A, Himmetoglu C, Huebner K, Güler G: Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland. Oral Oncol; 2010 Mar;46(3):195-9
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  • [Title] Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland.
  • Mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) are salivary gland neoplasms with divergent morphological features and clinical behavior.
  • In previous studies, we have shown concordant loss of Fhit and Wwox expression in breast cancer, with significantly more frequent loss in cancers of basal-like phenotype.
  • To determine if there is a similar association in salivary gland neoplasms, we designed a study of MEC and ACC of salivary gland on tissue microarrays (TMA).
  • TMAs were constructed from 25 MEC and 19 ACC of salivary gland.
  • The results suggest that, as for breast cancer, loss of Fhit and Wwox expression might have a role in the pathogenesis of basaloid differentiation in salivary gland neoplasms; alternatively, differences in chromatin structure at chromosome fragile regions might make fragile genes more accessible to DNA damage and rearrangement early during preneoplastic stages of basaloid cancers.
  • [MeSH-major] Acid Anhydride Hydrolases / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / metabolism. Neoplasm Proteins / metabolism. Oxidoreductases / metabolism. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism

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  • [Copyright] (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20060354.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Tumor Suppressor Proteins; 0 / fragile histidine triad protein; EC 1.- / Oxidoreductases; EC 1.1.1.- / WWOX protein, human; EC 3.6.- / Acid Anhydride Hydrolases
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6. Vékony H, Ylstra B, Wilting SM, Meijer GA, van de Wiel MA, Leemans CR, van der Waal I, Bloemena E: DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma. Clin Cancer Res; 2007 Jun 1;13(11):3133-9
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  • [Title] DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma.
  • PURPOSE: Adenoid cystic carcinoma (ACC) is a malignant salivary gland tumor with a high mortality rate due to late, distant metastases.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. DNA, Neoplasm / metabolism. Gene Expression Regulation, Neoplastic. Intercellular Signaling Peptides and Proteins / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 17545515.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Intercellular Signaling Peptides and Proteins; 0 / Platelet-Derived Growth Factor; 62031-54-3 / Fibroblast Growth Factors; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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7. Wegner A, Waśniewska E, Jarmołowska-Jurczyszyn D, Golusiński W, Biczysko W: [The role of immunohistochemical staining (protein p53, cyclin D1) in the prognosis of adenoid cystic carcinoma salivary gland tumors]. Otolaryngol Pol; 2007;61(4):423-7
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  • [Title] [The role of immunohistochemical staining (protein p53, cyclin D1) in the prognosis of adenoid cystic carcinoma salivary gland tumors].
  • [Transliterated title] Rola badań immunohistochemicznych (białka p53, cykliny D1) w prognozowaniu raka gruczołowato-torbielowatego (carcinoma adenoides cysticum) ślinianek.
  • INTRODUCTION: Adenoid cystic carcinoma of the salivary glands (carcinoma adenoides cysticum) is malignant epithelial tumor of rare occurrence.
  • Tumor of this kind has among salivary glands tumors uncertain prognosis and unpredictable course.
  • MATERIAL AND METHODS: The examined group consisted of 30 patients with adenoid cystic carcinoma of the salivary glands.
  • There was not statistically significant difference between the advanced grading of the organic and clinical adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Cyclin D1 / biosynthesis. Salivary Gland Neoplasms / diagnosis. Tumor Suppressor Protein p53 / biosynthesis


8. Zhang CY, Mao L, Li L, Tian Z, Zhou XJ, Zhang ZY, Li J: Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. Cancer; 2007 Jul 1;110(1):87-95
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  • [Title] Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma.
  • BACKGROUND: The role of promoter methylation in the inactivation of E-cadherin (E-cad) in salivary gland adenoid cystic carcinoma (ACC) is unknown.
  • The objective of this study was to determine the role and potential clinical implications of promoter methylation of E-cad in salivary gland ACC.
  • METHODS: The promoter methylation status of E-cad was determined by using methylation-specific polymerase chain reaction (PCR) analysis in 60 primary salivary gland ACC tissues and 3 ACC cell lines.
  • CONCLUSIONS: E-cad frequently is inactivated in salivary gland ACC through promoter methylation, and E-cad promoter methylation may play a role in tumor cell differentiation and perineural invasion.
  • [MeSH-major] Cadherins / genetics. Carcinoma, Adenoid Cystic / pathology. DNA Methylation. Promoter Regions, Genetic. Salivary Gland Neoplasms / pathology

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  • [Copyright] Copyright (c) 2007 American Cancer Society.
  • (PMID = 17520682.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / RNA, Messenger
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9. Daa T, Yada N, Kashima K, Suzuki M, Yokoyama S: Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland. Mol Med Rep; 2009 Jan-Feb;2(1):13-5
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  • [Title] Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland.
  • SMAD4, also known as DPC4 (deleted in pancreatic carcinoma 4) was initially identified as a tumor-suppressor gene.
  • It is located on 18q21, a region frequently deleted in pancreatic carcinoma.
  • Functionally inactivating mutation of the gene also occurs in many cases of pancreatic cancer.
  • Functional loss of SMAD4 is frequently detected not only in pancreatic carcinoma but also in colorectal carcinoma.
  • The purpose of this study was to elucidate the role of SMAD4 in adenoid cystic carcinoma of the salivary glands.
  • We examined 34 cases of adenoid cystic carcinoma for loss of heterozygosity (LOH) of the SMAD4 locus and for the existence of mutations of the gene.
  • In conclusion, the infrequent LOH of the SMAD4 gene locus and lack of SMAD4 mutations indicate that SMAD4 does not play a role in the tumorigenesis of adenoid cystic carcinoma of the salivary gland.

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  • (PMID = 21475783.001).
  • [ISSN] 1791-2997
  • [Journal-full-title] Molecular medicine reports
  • [ISO-abbreviation] Mol Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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10. Elkin AD, Jacobs CD: Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases. J Cancer Res Clin Oncol; 2008 Oct;134(10):1151-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases.
  • PURPOSE: Adenoid cystic carcinoma of the salivary gland (ACC-SG) is a slow-growing tumor that is refractory to most chemotherapeutic agents.
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Salivary Gland Neoplasms / drug therapy. Tamoxifen / therapeutic use

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  • (PMID = 18347813.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 094ZI81Y45 / Tamoxifen; 7NFE54O27T / Toremifene
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11. Handra-Luca A, Mauguen A, Ménard P, Fouret P: Coordinated expression of activated mitogen-activated protein kinases in salivary gland adenoid cystic carcinoma. Hum Pathol; 2008 Nov;39(11):1590-6
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  • [Title] Coordinated expression of activated mitogen-activated protein kinases in salivary gland adenoid cystic carcinoma.
  • Little is known regarding the mitogen-activated protein kinase activation state in salivary gland adenoid cystic carcinoma.
  • Our study provides evidence that mitogen-activated protein kinases are activated in adenoid cystic carcinoma and suggests that their activation is coordinated.
  • [MeSH-major] Carcinoma, Adenoid Cystic / enzymology. Mitogen-Activated Protein Kinases / metabolism. Salivary Gland Neoplasms / enzymology

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  • (PMID = 18657296.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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12. Wang YY, Chen WL, Yang ZH, Huang ZQ, Li JS, Pan CB: [Effects of Ezrin gene on the proliferation and invasion activity of human salivary gland adenoid cystic carcinoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2009 Apr;44(4):203-7
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  • [Title] [Effects of Ezrin gene on the proliferation and invasion activity of human salivary gland adenoid cystic carcinoma].
  • OBJECTIVE: To examine the expression of Ezrin in human salivary gland adenoid cystic carcinoma and investigate the effects of Ezrin gene silence on cell proliferation, apoptosis and invasion of adenoid cystic carcinoma (ACC)-M.
  • METHODS: The expression of Ezrin was detected by immunohistochemistry in normal salivary gland tissue (n=15), pleomorphic adenoma (n=40) and salivary gland adenoid cystic carcinoma (n=43).
  • RESULTS: The positive rate of Ezrin expression in ACC was significantly higher than that in normal salivary gland tissue and pleomorphic adenoma (P<0.05).
  • CONCLUSIONS: Over expression of Ezrin in human salivary gland adenoid cystic carcinoma may promote genesis, development and metastasis of tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Cytoskeletal Proteins / genetics. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 19575999.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cytoskeletal Proteins; 0 / ezrin
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13. Fu ZC, Zhang B, Fu ZJ: As2O3 may be a treatment option for adenoid cystic carcinoma of salivary gland. Med Hypotheses; 2010 Dec;75(6):490-1
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  • [Title] As2O3 may be a treatment option for adenoid cystic carcinoma of salivary gland.
  • Adenoid cystic carcinoma (ACC) is an uncommon tumor of the head and neck that may occur in any salivary gland tissue.
  • ACC mostly occurring in the major and minor salivary glands, has some unique characteristics such as slow growth, diffuse invasion, and high incidence of distant metastasis.
  • It is a high malignant carcinoma characterized by intensive local invasion and insidious distant metastasis to the lung at an early stage, which is responsible for a poor long-term survival rate.
  • The main clinical treatment to adenoid cystic carcinoma depended on surgical operation in the past.
  • However, it was not so easy to completely excise adenoid cystic carcinoma which resulting in the residual of tumor cells.
  • Adenoid cystic carcinoma is not sensitive to conventional chemotherapeutics, so it is necessary to explore a new kind of drug which possesses inhibition and killing effects to this tumor.
  • It also induces apoptosis in a variety of cancer cells over a wide dose range.
  • A(S2)O(3) may become a treatment option for adenoid cystic carcinoma of salivary gland.
  • [MeSH-major] Apoptosis / drug effects. Arsenicals / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Growth Inhibitors / therapeutic use. Oxides / therapeutic use. Salivary Gland Neoplasms / drug therapy

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20656411.001).
  • [ISSN] 1532-2777
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arsenicals; 0 / Growth Inhibitors; 0 / Oxides; S7V92P67HO / arsenic trioxide
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14. Wang XF, Wu DM, Li BX, Lu YJ, Yang BF: Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma. Phytother Res; 2009 Mar;23(3):303-7
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  • [Title] Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma.
  • The present study aimed to evaluate the growth-inhibitory effect of sulforaphane (SFN) and a traditional chemotherapy agent, 5-fluorouracil (5-Fu), against the proliferation of salivary gland adenoid cystic carcinoma high metastatic cell line (ACC-M) and low metastasis cell line (ACC-2).
  • [MeSH-major] Carcinoma, Adenoid Cystic / drug therapy. Fluorouracil / pharmacology. Salivary Gland Neoplasms / drug therapy. Thiocyanates / pharmacology

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  • [Copyright] (c) 2008 John Wiley & Sons, Ltd.
  • (PMID = 18844240.001).
  • [ISSN] 1099-1573
  • [Journal-full-title] Phytotherapy research : PTR
  • [ISO-abbreviation] Phytother Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Isothiocyanates; 0 / Thiocyanates; 0 / Transcription Factor RelA; 4478-93-7 / sulforafan; U3P01618RT / Fluorouracil
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15. Daa T, Kaku N, Kashima K, Nakayama I, Yokoyama S: Expression of beta-catenin, E-cadherin and cyclin D1 in adenoid cystic carcinoma of the salivary gland. J Exp Clin Cancer Res; 2005 Mar;24(1):83-7
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  • [Title] Expression of beta-catenin, E-cadherin and cyclin D1 in adenoid cystic carcinoma of the salivary gland.
  • We evaluated the expression of beta-catenin, E-cadherin, and cyclin-D1 in 23 cases of adenoid cystic carcinoma (ACC) of the salivary gland.
  • [MeSH-major] Cadherins / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cyclin D1 / metabolism. Cytoskeletal Proteins / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / pathology. Trans-Activators / metabolism


16. Jiang J, Tang Y, Zhu G, Zheng M, Yang J, Liang X: Correlation between transcription factor Snail1 expression and prognosis in adenoid cystic carcinoma of salivary gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Dec;110(6):764-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation between transcription factor Snail1 expression and prognosis in adenoid cystic carcinoma of salivary gland.
  • The aim of the present study was to study the association of Snail1 expression with clinicopathologic factors and prognosis in adenoid cystic carcinoma (ACC) of salivary gland.
  • STUDY DESIGN: Demographic variables and primary tumor site, dates of diagnoses, perineural invasion, local regional recurrence, and distant metastasis of 121 cases of salivary ACC were retrieved.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Gene Expression Regulation, Neoplastic / genetics. Salivary Gland Neoplasms / pathology. Transcription Factors / analysis. Zinc Fingers / genetics
  • [MeSH-minor] Epithelial-Mesenchymal Transition / genetics. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Prognosis. Salivary Glands / pathology. Survival Rate. Treatment Outcome

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20952218.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Transcription Factors; 0 / snail family transcription factors
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17. Tang Y, Liang X, Zhu G, Zheng M, Yang J, Chen Y: Expression and importance of zinc-finger transcription factor Slug in adenoid cystic carcinoma of salivary gland. J Oral Pathol Med; 2010 Nov;39(10):775-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and importance of zinc-finger transcription factor Slug in adenoid cystic carcinoma of salivary gland.
  • However, there is little information on the expression and role of Slug in salivary adenoid cystic carcinoma (ACC).
  • METHOD: Demographic variables and primary tumor site, dates of diagnoses, perineural invasion, local regional recurrence, and distant metastasis of 121 cases of salivary ACC treated at the Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University between 1996 and 2005 were retrieved.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology. Transcription Factors / metabolism. Zinc Fingers / physiology

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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 20738754.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Transcription Factors; 0 / snail family transcription factors
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18. Chu WF, Wu DM, Liu W, Wu LJ, Li DZ, Xu DY, Wang XF: Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma. Oral Oncol; 2009 Nov;45(11):998-1004
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  • [Title] Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma.
  • New chemotherapeutic strategy should be investigated to enhance clinical management in salivary gland adenoid cystic carcinoma (ACC).
  • Recently, sulforaphane (SFN), as a natural compound from cruciferous vegetables exhibits a potent anti-cancer activity in various tumor cells, but remains uncertain in ACC cells.
  • Cell survives, apoptosis, cell cycle progression and molecular targets were identified by multiple detecting techniques, including trypan blue dye exclusion assay, electron microscopy, AO/EB staining, flow cytometry and immunoblotting in human lung high metastasis cell line of salivary gland adenoid cystic carcinoma (ACC-M).
  • [MeSH-major] Anticarcinogenic Agents / pharmacology. Carcinoma, Adenoid Cystic / drug therapy. Lung Neoplasms / drug therapy. Salivary Gland Neoplasms / drug therapy. Thiocyanates / pharmacology


19. Tan Z, Ling ZQ, Chen C, Xu JJ, Ge MH: [Evolution pattern of the Runx3 gene 5'-CpG island methylation in human salivary gland adenoid cystic carcinoma]. Zhonghua Zhong Liu Za Zhi; 2010 Dec;32(12):907-12
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  • [Title] [Evolution pattern of the Runx3 gene 5'-CpG island methylation in human salivary gland adenoid cystic carcinoma].
  • OBJECTIVE: To investigate the evolution pattern of the Runx3 gene 5'-CpG island ~3478 bp region methylation in human salivary gland adenoid cystic carcinoma (SGACC).
  • METHODS: Quantitative MSP method was used to detect the methylation status of CpG island in various regions (No.1-10) of Runx3 promoter region, and Western blot was used for detection of the expression of Runx3 protein in 41 salivary gland SGACC samples and corresponding non-neoplastic salivary gland tissues.
  • A Logistic model was used to analyze the risk ratio between the methylation status of CpG island in Runx3 gene and development of salivary SGACC, meanwhile, the possible association among the methylation of Runx3 gene, the clinicopathological parameters of SGACCs, and Runx3 protein expression was compared.
  • The methylation rate was highest in region No. 1 and No. 2 among the successive ten regions ranging from the 5' region to the transcription start site within the Runx3 CpG island, and lowest in the transcription start site both in SGACCs and normal salivary glands.
  • Furthermore, there was no methylation in the transcription start site in nomal salivary glands tissues.
  • Western blot results revealed that the Runx3 protein level in SGACC was significantly lower than that in normal salivary glands (P < 0.01).
  • CONCLUSIONS: Methylation of the Runx3 CpG island spreads from the most 5'-region to the transcription start site in human salivary gland adenoid cystic carcinoma, and the transcription start site may be a critical region for the methylation of Runx3.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Core Binding Factor Alpha 3 Subunit / genetics. CpG Islands / genetics. DNA Methylation. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Logistic Models. Male. Middle Aged. Salivary Glands / metabolism

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  • (PMID = 21223798.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 3 Subunit; 0 / Runx3 protein, human
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20. Daa T, Kashima K, Kondo Y, Yada N, Suzuki M, Yokoyama S: Aberrant methylation in promoter regions of cyclin-dependent kinase inhibitor genes in adenoid cystic carcinoma of the salivary gland. APMIS; 2008 Jan;116(1):21-6
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  • [Title] Aberrant methylation in promoter regions of cyclin-dependent kinase inhibitor genes in adenoid cystic carcinoma of the salivary gland.
  • Adenoid cystic carcinoma (ACC) is a common malignant neoplasm of the salivary gland.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Cyclin-Dependent Kinase Inhibitor Proteins / genetics. Genes, Tumor Suppressor. Promoter Regions, Genetic. Salivary Gland Neoplasms / genetics

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  • (PMID = 18254776.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p18; 0 / Cyclin-Dependent Kinase Inhibitor p21; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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21. Freier K, Flechtenmacher C, Walch A, Ohl S, Devens F, Burke B, Hassfeld S, Lichter P, Joos S, Hofele C: Copy number gains on 22q13 in adenoid cystic carcinoma of the salivary gland revealed by comparative genomic hybridization and tissue microarray analysis. Cancer Genet Cytogenet; 2005 May;159(1):89-95
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  • [Title] Copy number gains on 22q13 in adenoid cystic carcinoma of the salivary gland revealed by comparative genomic hybridization and tissue microarray analysis.
  • Adenoid cystic carcinoma (ACC) of the salivary gland is a neoplasm characterized by slow but inevitable local progression and terminal hematogenous metastasis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 22 / genetics. Microarray Analysis. Nucleic Acid Hybridization. Salivary Gland Neoplasms / genetics

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  • (PMID = 15860365.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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22. Vékony H, Raaphorst FM, Otte AP, van Lohuizen M, Leemans CR, van der Waal I, Bloemena E: High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma. J Clin Pathol; 2008 Jun;61(6):744-9
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  • [Title] High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma.
  • BACKGROUND: The prognosis of adenoid cystic carcinoma (ACC), a malignant salivary gland tumour, depends on clinicopathological parameters.
  • RESULTS: ACC revealed significantly increased expression of the cell cycle proteins compared to normal salivary tissue (n = 17).
  • Members of the two PcG complexes displayed mutually exclusive expression in normal salivary gland tissue, with BMI-1 and MEL-18 being abundantly present.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. DNA-Binding Proteins / analysis. Salivary Gland Neoplasms / chemistry. Transcription Factors / analysis

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  • (PMID = 18326020.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Transcription Factors; EC 2.1.1.43 / EZH2 protein, human; EC 2.1.1.43 / Polycomb Repressive Complex 2
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23. Zhao JF, Li XM, Xie WH, Wang HB, Fang Z, Li QC: [Effect and mechanism of matrine on adhesion and invasion of salivary gland adenoid cystic carcinoma cells in vitro]. Shanghai Kou Qiang Yi Xue; 2009 Aug;18(4):401-5
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  • [Title] [Effect and mechanism of matrine on adhesion and invasion of salivary gland adenoid cystic carcinoma cells in vitro].
  • PURPOSE: To investigate the effect and mechanism of matrine on adhesion and invasion of human adenoid cystic carcinoma ACC-M cells in vitro.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Cell Line, Tumor
  • [MeSH-minor] Alkaloids. Cell Adhesion. Humans. In Vitro Techniques. Quinolizines. Salivary Gland Neoplasms. Salivary Glands

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  • (PMID = 19760015.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Alkaloids; 0 / Quinolizines; 519-02-8 / matrine
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24. Li J, El-Naggar A, Mao L: Promoter methylation of p16INK4a, RASSF1A, and DAPK is frequent in salivary adenoid cystic carcinoma. Cancer; 2005 Aug 15;104(4):771-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Promoter methylation of p16INK4a, RASSF1A, and DAPK is frequent in salivary adenoid cystic carcinoma.
  • However, little is known about its role in the development of adenoid cystic carcinoma of the salivary gland (ACC).
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Genes, Tumor Suppressor. Methylation. Promoter Regions, Genetic. Salivary Gland Neoplasms / genetics

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  • (PMID = 15959912.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01 CA106451
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / RASSF1 protein, human; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / Death-Associated Protein Kinases; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases
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25. Liu X, Zhang Y, Ren W, Cao T, Zhu Y: RNAi knockdown of C-erbB2 expression inhibits salivary gland adenoid cystic carcinoma SACC-83 cell growth in vitro. J Biomed Res; 2010 May;24(3):215-22
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  • [Title] RNAi knockdown of C-erbB2 expression inhibits salivary gland adenoid cystic carcinoma SACC-83 cell growth in vitro.
  • OBJECTIVE: To knockdown the C-erbB2 gene in salivary gland adenoid cystic carcinoma SACC-83 cells using RNA interference, and determine the effect of silencing C-erbB2 on cell proliferation.
  • RESULTS: Compared with the control, C-erbB2 mRNA expression was decreased in the C-erbB2-siRNA transfection group, and immunohistochemical analysis indicated that C-erbB2 protein expression was decreased.
  • The differences were statistically significant (P < 0.05) between the C-erbB2-siRNA group and the control groups.
  • Following the C-erbB2 knockdown, the percentage of apoptotic cells was 5.63% compared with 2.04%, 2.85%, and 2.98% in the three control groups, respectively.
  • CONCLUSION: RNA interference can effectively silence C-erbB2 gene expression and inhibit growth of SACC-83 cells, which indicates the potential of targeting this gene as a novel gene therapy approach for the treatment of salivary gland adenoid cystic carcinoma.

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  • (PMID = 23554633.001).
  • [ISSN] 1674-8301
  • [Journal-full-title] Journal of biomedical research
  • [ISO-abbreviation] J Biomed Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3596557
  • [Keywords] NOTNLM ; C-erbB2 / RNA interference / gene silence / salivary gland adenoid cystic carcinoma
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26. Greer RO Jr, Said S, Shroyer KR, Marileila VG, Weed SA: Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma. Oral Oncol; 2007 Sep;43(8):735-41
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  • [Title] Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma.
  • Adenoid cystic carcinoma (ACC) of the salivary glands exhibits persistent growth, invasion and metastasis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Cortactin / metabolism. Cyclin D1 / metabolism. Neoplasm Proteins / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17113340.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE014364; United States / NIDCR NIH HHS / DE / DE014578
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTTN protein, human; 0 / Cortactin; 0 / Neoplasm Proteins; 136601-57-5 / Cyclin D1
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27. Kawamata T, Harashima S, Kubo O, Hori T: Intrasellar remote metastasis from adenoid cystic carcinoma of parotid gland: case report. Endocr J; 2006 Oct;53(5):659-63
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  • [Title] Intrasellar remote metastasis from adenoid cystic carcinoma of parotid gland: case report.
  • Adenoid cystic carcinoma is a tumor of exocrine glands originating primarily from the minor and major salivary glands, lacrimal gland, bronchus, breast, and intestinal and genital tracts.
  • Intracranial remote metastasis from adenoid cystic carcinoma in salivary gland is quite rare.
  • The authors encountered a case of intrasellar remote metastasis from an adenoid cystic carcinoma of parotid gland origin, presenting with hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
  • To our knowledge, this is the first reported case of metastasis from an adenoid cystic carcinoma to intrasellar area.
  • A 78-year-old woman had an adenoid cystic carcinoma in the left parotid gland, which was resected surgically followed by local radiation therapy of 60 Gy.
  • Histopathological examination of the tumor specimens revealed adenoid cystic carcinoma, which had identical histological findings as those of the painful superficial cervical lymph nodes resected in the same operation.
  • Although rare, metastasis from tumors including those of salivary gland origin should be considered in the differential diagnosis of unusual pituitary tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology. Pituitary Neoplasms / secondary. Sella Turcica

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  • (PMID = 16902261.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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28. Xia H, Li LJ, Han B, Pan J, Gao N: [Research on the differently expressed homeobox genes related to adenoid cystic carcinoma]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2010 Apr;28(2):190-4
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  • [Title] [Research on the differently expressed homeobox genes related to adenoid cystic carcinoma].
  • OBJECTIVE: To investigate the differently expressed Homeobox genes between adenoid cystic carcinoma of salivary gland and normal gland tissue, and find out the effect of homeobox genes on oncogenesis and differentiation of adenoid cystic carcinoma of salivary gland.
  • METHODS: Six strictly paired specimens including adenoid cystic carcinoma and its surrounding normal gland tissue and two pairs of specimens including cell strain of adenoid cystic carcinoma and its surrounding normal gland tissue were established.
  • RT-PCR technique was used to examine the mRNA expressing level of highly suspected relevant genes of adenoid cystic carcinoma in different specimens.
  • RT-PCI showed that there was statistical expressing difference between TGIF, EVX1 and normal gland tissue in ACC-M.
  • CONCLUSION: As the key gene to cellular proliferation and differentiation, homeobox genes are closely relevant to the oncogenesis of adenoid cystic carcinoma of salivary gland.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Salivary Gland Neoplasms

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  • (PMID = 20480666.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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29. Ge MH, Ling ZQ, Tan Z, Chen C, Zheng CM, Xu JJ, Zhu X: [RUNX3 expression and its methylation of 5'-CpG island in salivary gland adenoid cystic carcinoma cell lines ACC-2, ACC-3 and ACC-M]. Zhonghua Yi Xue Za Zhi; 2010 Dec 28;90(48):3426-30
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  • [Title] [RUNX3 expression and its methylation of 5'-CpG island in salivary gland adenoid cystic carcinoma cell lines ACC-2, ACC-3 and ACC-M].
  • OBJECTIVE: To investigate the methylation of 5'-CpG island and expression of RUNX3 in salivary gland adenoid cystic carcinoma cell lines.
  • METHODS: RT-PCR (reverse transcription-polymerase chain reaction), laser scanning confocal microscope (LSCM) and Western blot were used to detect the expression of RUNX3 gene and protein in salivary gland adenoid cystic carcinoma cell lines, ACC-2, ACC-3, and ACC-M, before/after a treatment of 5-Aza-dc respectively.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Core Binding Factor Alpha 3 Subunit / metabolism. CpG Islands. Salivary Gland Neoplasms / metabolism

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  • (PMID = 21223819.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 3 Subunit; 0 / Runx3 protein, human
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30. Zhang J, Peng B: NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro. Cell Prolif; 2009 Apr;42(2):150-61
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  • [Title] NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro.
  • Tumour cell-derived angiogenic-related factors and endothelial cell mobility are essential for neovascularization and haematogenous metastasis of adenoid cystic carcinoma (ACC) of the human salivary glands.
  • CONCLUSIONS: Our results suggest that NF-kappaB promotes iNOS and VEGF expression in salivary gland ACC cells and enhances endothelial cell motility in vitro.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Cell Movement / physiology. Endothelial Cells / cytology. NF-kappa B / physiology. Nitric Oxide Synthase Type II / metabolism. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Cell Line. Cell Line, Tumor / drug effects. Cell Proliferation / drug effects. Culture Media, Conditioned / pharmacology. Gene Expression / drug effects. Humans. I-kappa B Proteins / genetics. I-kappa B Proteins / metabolism. Lipopolysaccharides / pharmacology. Mutation / physiology. NF-kappa B p50 Subunit / metabolism. Neovascularization, Physiologic / drug effects. Neovascularization, Physiologic / physiology. Nitrites / metabolism. Salivary Gland Neoplasms / metabolism. Transcription Factor RelA / metabolism. Transfection

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  • (PMID = 19317804.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Culture Media, Conditioned; 0 / I-kappa B Proteins; 0 / Lipopolysaccharides; 0 / NF-kappa B; 0 / NF-kappa B p50 Subunit; 0 / Nitrites; 0 / Transcription Factor RelA; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 139874-52-5 / NF-kappaB inhibitor alpha; EC 1.14.13.39 / NOS2 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase Type II
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31. Perez DE, Magrin J, de Almeida OP, Kowalski LP: Multiple cutaneous metastases from a parotid adenoid cystic carcinoma. Pathol Oncol Res; 2007;13(2):167-9
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  • [Title] Multiple cutaneous metastases from a parotid adenoid cystic carcinoma.
  • Cutaneous metastasis from salivary gland adenoid cystic carcinoma is extremely rare.
  • We report a case of a 39-year-old man that presented multiple cutaneous metastases from a parotid salivary gland adenoid cystic carcinoma.
  • This case shows the importance of a detailed and periodical skin examination in patients treated for salivary gland adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Parotid Neoplasms / pathology. Skin Neoplasms / secondary

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  • [Cites] Head Neck. 2005 Dec;27(12):1022-7 [16265655.001]
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  • (PMID = 17607381.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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32. Demirci H, Vine AK, Elner VM: Choroidal metastasis from submandibular salivary gland adenoid cystic carcinoma. Ophthalmic Surg Lasers Imaging; 2008 Jan-Feb;39(1):57-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Choroidal metastasis from submandibular salivary gland adenoid cystic carcinoma.
  • A case of choroidal metastasis from an adenoid cystic carcinoma ofsubmandibular salivary gland is described.
  • A choroidal biopsy was consistent with metastatic adenoid cystic carcinoma from her submandibular salivary gland treated 5 years previously.
  • All of the metastases demonstrated a basaloid histologic variant of adenoid cystic carcinoma that is known for its aggressive potential.
  • Salivary gland carcinoma rarely metastasizes to the choroid; however, evaluation of patients with this carcinoma should include ophthalmic examination.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Choroid Neoplasms / secondary. Submandibular Gland Neoplasms / pathology

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  • (PMID = 18254353.001).
  • [ISSN] 1542-8877
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Zhang J, Peng B: In vitro angiogenesis and expression of nuclear factor kappaB and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma. BMC Cancer; 2007;7:95
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  • [Title] In vitro angiogenesis and expression of nuclear factor kappaB and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma.
  • BACKGROUND: Adenoid cystic carcinoma is a high malignant carcinoma characterized by intensive local invasion and high incidence of distant metastasis.
  • Although many reports have demonstrated that angiogenesis has played an important role in tumor metastasis, the relationship between metastasis characters and angiogenesis ability in high and low metastasis cell lines of Adenoid cystic carcinoma has rarely been reported.
  • [MeSH-major] Carcinoma, Adenoid Cystic / blood supply. Carcinoma, Adenoid Cystic / secondary. Neovascularization, Pathologic / pathology. Salivary Gland Neoplasms / blood supply. Transcription Factor RelA / metabolism. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 17543095.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Transcription Factor RelA; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
  • [Other-IDs] NLM/ PMC1903362
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34. Dodd RL, Slevin NJ: Salivary gland adenoid cystic carcinoma: a review of chemotherapy and molecular therapies. Oral Oncol; 2006 Sep;42(8):759-69
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  • [Title] Salivary gland adenoid cystic carcinoma: a review of chemotherapy and molecular therapies.
  • Adenoid cystic carcinoma (ACC) accounts for about 1% of all head and neck malignancies.
  • Standard treatment for salivary gland ACC is surgery and post-operative radiotherapy.
  • The aim of this review was to examine the reported efficacy of various chemotherapy regimens and molecular therapies on recurrent/metastatic salivary gland ACC.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Salivary Gland Neoplasms / drug therapy


35. Alfaro-Rubio A, Sanmartín Jiménez O, Serra-Guillén C, Requena Caballero C, Hueso Gabriel L, Botella-Estrada R, Nagore Enguídanos E, Llombart Cussac B, Guillén Barona C: [Adenoid cystic carcinoma]. Actas Dermosifiliogr; 2006 Nov;97(9):578-80
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  • [Title] [Adenoid cystic carcinoma].
  • [Transliterated title] Carcinoma adenoide quístico.
  • Adenoid cystic carcinoma is an uncommon tumor of the head and neck.
  • Although it is mainly located in the salivary gland, a skin location has also been described.
  • After resection, the histological diagnosis was adenoid cystic carcinoma.
  • Its histological diagnosis was lymphatic metastasis due to adenoid cystic carcinoma.
  • Primary cutaneous adenoid cystic carcinoma is a very uncommon tumor in which treatment consists in extensive local excision with free margins.
  • Multicenter, prospective studies are necessary to determine the best treatment and especially the adjuvant treatment for adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lip Neoplasms / pathology

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  • (PMID = 17173761.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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36. De Dosso S, Mazzucchelli L, Ghielmini M, Saletti P: Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma. Tumori; 2009 May-Jun;95(3):378-81
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  • [Title] Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma.
  • Esophageal localization of adenoid cystic carcinoma of minor salivary glands is rare; it may occur in the early to mid-sixties' age group and is more frequently encountered in men than women.
  • In the majority of cases, it arises from subepithelial glands of the middle to lower third of the esophagus, a similar distribution as squamous cell carcinoma.
  • We report a case of a patient with metastatic primary esophageal adenoid cystic carcinoma progressing on platinum- and irinotecan-based regimens, who achieved an objective response with oxaliplatin-based chemotherapy in combination with cetuximab.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / secondary. Esophageal Neoplasms / pathology. Salivary Gland Neoplasms / drug therapy. Salivary Gland Neoplasms / secondary

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  • (PMID = 19688981.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Biomarkers, Tumor; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; PQX0D8J21J / Cetuximab
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37. Netto Jde N, Miranda AM, da Silveira HM, dos Santos TC, Pires FR: Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Aug;106(2):242-5
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  • [Title] Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma.
  • BACKGROUND: Fine-needle aspiration biopsy (FNAB) is useful in diagnosis of major salivary gland adenoid cystic carcinoma (ACC), but it has been rarely reported on minor salivary gland ACC.
  • OBJECTIVE: The aim of this study was to report the utility of FNAB on diagnosis of ACC involving minor salivary glands.
  • Diagnosis of the 3 cases was subsequently confirmed through histopathology.
  • CONCLUSION: The FNAB was easy to perform and cost-effective, and proved to be an useful adjunctive tool in diagnosis of intraoral ACC.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adult. Cell Nucleus / ultrastructure. Cheek / pathology. Coloring Agents. Cytodiagnosis / methods. Cytoplasm / ultrastructure. Diagnosis, Differential. Extracellular Space. Female. Fluorescent Dyes. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Palatal Neoplasms / pathology

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  • (PMID = 18644520.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Fluorescent Dyes
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38. Sasahira T, Oue N, Kirita T, Luo Y, Bhawal UK, Fujii K, Yasui W, Kuniyasu H: Reg IV expression is associated with cell growth and prognosis of adenoid cystic carcinoma in the salivary gland. Histopathology; 2008 Dec;53(6):667-75
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  • [Title] Reg IV expression is associated with cell growth and prognosis of adenoid cystic carcinoma in the salivary gland.
  • The aim was to examine Reg IV expression in adenoid cystic carcinomas (ACCs) in salivary glands.
  • Reg IV was expressed by salivary duct epithelia and acinus myoepithelia, but not in squamous epithelia.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lectins, C-Type / metabolism. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology


39. Zhang B, Sun CF: [The expression of tumor suppressor gene PTEN protein and focal adhesion kinase in salivary adenoid cystic carcinoma and its significance]. Shanghai Kou Qiang Yi Xue; 2005 Dec;14(6):578-81
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  • [Title] [The expression of tumor suppressor gene PTEN protein and focal adhesion kinase in salivary adenoid cystic carcinoma and its significance].
  • PURPOSE: To investigate the expression of focal adhesion kinase(FAK) and PTEN in salivary adenoid cystic carcinoma (SACC) and its significance.
  • RESULTS: The expressions of FAK in salivary adenoid cystic carcinoma was 94%, and the negative expressions of PTEN was 70%.There was a significant difference between normal salivary gland and salivary adenoid cystic carcinoma (P<0.01).
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Focal Adhesion Kinase 1 / metabolism. PTEN Phosphohydrolase / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Humans. Salivary Glands / metabolism

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  • (PMID = 16400482.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.10.2 / Focal Adhesion Kinase 1; EC 2.7.10.2 / PTK2 protein, human; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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40. Talmon GA, Khan A, Koerber R, Lele S, Johansson S: A cribriform urothelial neoplasm of the renal pelvis: an adenoid cysticlike variant of inverted urothelial papilloma or florid ureteritis cystica? Arch Pathol Lab Med; 2010 Oct;134(10):1557-9
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  • [Title] A cribriform urothelial neoplasm of the renal pelvis: an adenoid cysticlike variant of inverted urothelial papilloma or florid ureteritis cystica?
  • Tumors with cribriform appearance, similar to that of salivary gland adenoid cystic carcinoma, have been described at various anatomic sites.
  • The mass displayed a prominent cribriform architecture, akin to adenoid cystic carcinoma with an immunophenotype that supported a urothelial origin.
  • This cribriform urothelial neoplasm of the renal pelvis may, in fact, represent a variant of an inverted urothelial neoplasm with a prominent cystic component or florid ureteritis cystica.
  • [MeSH-major] Carcinoma, Transitional Cell / pathology. Neoplasms, Connective Tissue / pathology. Papilloma / pathology. Papilloma, Inverted / pathology. Urologic Neoplasms / pathology. Urothelium / pathology
  • [MeSH-minor] Aged, 80 and over. Cell Division. Diagnosis, Differential. Humans. Immunophenotyping / methods. Kidney Pelvis / pathology. Male. Proto-Oncogene Proteins c-kit / analysis. Urinary Bladder Neoplasms / pathology

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  • (PMID = 20923313.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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41. Freitas VM, Vilas-Boas VF, Pimenta DC, Loureiro V, Juliano MA, Carvalho MR, Pinheiro JJ, Camargo AC, Moriscot AS, Hoffman MP, Jaeger RG: SIKVAV, a laminin alpha1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through the ERK 1/2 signaling pathway. Am J Pathol; 2007 Jul;171(1):124-38
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  • [Title] SIKVAV, a laminin alpha1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through the ERK 1/2 signaling pathway.
  • Adenoid cystic carcinoma is a frequently occurring malignant salivary gland neoplasm.
  • Laminin alpha1 and matrix metalloproteinases (MMPs) 2 and 9 were immunolocalized in adenoid cystic carcinoma cells in vivo and in vitro.
  • We propose that SIKVAV increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through alpha3beta1 and alpha6beta1 integrins and the ERK 1/2 signaling pathway.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Integrins / metabolism. Laminin / metabolism. Matrix Metalloproteinases / metabolism. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / metabolism. Oligopeptides / pharmacology. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17591960.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Integrin alpha6; 0 / Integrins; 0 / Laminin; 0 / Oligopeptides; 146163-06-6 / seryl-isoleucyl-lysyl-valyl-alanyl-valinamide; 151186-83-3 / laminin A; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
  • [Other-IDs] NLM/ PMC1941583
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42. Haresh KP, Prabhakar R, Rath GK, Sharma DN, Julka PK, Subramani V: Adenoid cystic carcinoma of the trachea treated with PET-CT based intensity modulated radiotherapy. J Thorac Oncol; 2008 Jul;3(7):793-5
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  • [Title] Adenoid cystic carcinoma of the trachea treated with PET-CT based intensity modulated radiotherapy.
  • Adenoid cystic carcinoma, which is of salivary gland origin, account for about one thirds of adult primary tracheal tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Positron-Emission Tomography. Radiotherapy, Intensity-Modulated. Tomography, X-Ray Computed. Tracheal Neoplasms / radiotherapy

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  • (PMID = 18594327.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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43. Sequeiros Santiago G, Rodrigo Tapia JP, Llorente Pendás JL, Suárez Nieto C: [Prognostic factors in adenoid cystic carcinoma of salivary glands]. Acta Otorrinolaringol Esp; 2005 Oct;56(8):361-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Prognostic factors in adenoid cystic carcinoma of salivary glands].
  • [Transliterated title] Factores pronósticos en el carcinoma adenoide quístico de glándulas salivares.
  • OBJECTIVE: Adenoid cystic carcinoma (ACC) is a relatively rare tumor which is characterized by its long clinical history, with multiple recurrences and late distant metastasis.
  • MATERIAL AND METHODS: A retrospective study was carried out between 1984 and 2004 in 28 patients with ACC of the salivary glands, analyzing the most outstanding clinico-pathological variables in this tumor related to the prognosis of the tumor and the survival.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 16285435.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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44. Teymoortash A, Ramaswamy A, Werner JA: [Adenoid cystic carcinoma secondary to heterotopic salivary gland tissue of the cervical lymph nodes]. Laryngorhinootologie; 2007 Jan;86(1):44-7
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  • [Title] [Adenoid cystic carcinoma secondary to heterotopic salivary gland tissue of the cervical lymph nodes].
  • [Transliterated title] Adenoidzystisches Karzinom im heterotopen Speicheldrüsengewebe der zervikalen Lymphknoten.
  • BACKGROUND: The presence of heterotopic salivary gland tissue in intra-, periparotideal and cervical lymph nodes is not an uncommen finding.
  • In some rare cases the salivary gland inclusions in lymph nodes may undergo neoplastic transformation.
  • The histological assessment of the extirpated node seemed to indicate lymph node metastasis of an adenoid cystic carcinoma.
  • RESULTS: Due to the fact of missing of a primary tumor, the diagnosis of an adenoid cystic carcinoma in heterotopic salivary gland tissue of the cervical lymph node was established after long-term observation.
  • CONCLUSION: After exclusion of an occult carcinoma of the salivary glands, the possibility of malignant transformation of heterotopic intranodal salivary gland inclusions should be considered in patients suffering from salivary gland carcinoma in the area of the cervical lymph nodes.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Cell Transformation, Neoplastic / pathology. Choristoma / pathology. Lymph Nodes / pathology. Otorhinolaryngologic Neoplasms / pathology. Salivary Glands
  • [MeSH-minor] Diagnosis, Differential. Humans. Lymph Node Excision. Male. Middle Aged

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  • (PMID = 16586289.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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45. Dardick I, Daley TD, McComb RJ: Sialoblastoma in adults: distinction from adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jan;109(1):109-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sialoblastoma in adults: distinction from adenoid cystic carcinoma.
  • No adult cases have been reported with a specific diagnosis of sialoblastoma.
  • If even focal cribriforming were present, such cases have undoubtedly been diagnosed as adenoid cystic carcinoma.
  • Each case, however, has the primitive histopathology with discrete nests of basaloid tumor cells, associated bilayered ductal structures and the fibromyxoid stroma characteristic for sialoblastoma with its resemblance to fetal salivary gland or salivary gland with arrested development.
  • Sialoblastoma, whether in a child or adult with or without a cribriform growth pattern, appears to have a more favorable prognosis than adenoid cystic carcinoma.
  • Aspects of the histological differential diagnosis of these 2 tumors are discussed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Palatal Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Facial Paralysis / etiology. Female. Humans. Male. Middle Aged. Palate, Hard / pathology. Parotid Neoplasms / complications. Parotid Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 19880331.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Qi ZZ, Shang DH, Qu CF, Sun CF: [The expression of M-phase promoting factor in salivary adenoid cystic carcinoma]. Shanghai Kou Qiang Yi Xue; 2007 Jun;16(3):243-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The expression of M-phase promoting factor in salivary adenoid cystic carcinoma].
  • PURPOSE: To study the expression and clinical significance of M-phase promoting factor (MPF) in salivary adenoid cystic carcinoma (SACC).
  • METHODS: The expression of MPF was investigated in 40 salivary adenoid cystic carcinomas and 40 normal salivary tissues by immunohistochemistry.
  • RESULTS: The expression of MPF was significantly higher in salivary adenoid cystic carcinoma than in normal salivary tissues(P<0.05).
  • CONCLUSIONS: MPF highly expressed in salivary adenoid cystic carcinoma, salivary adenoid cystic carcinoma correlated with the expression of MPF and the abnormal activation of MPF was one of the factors for the proliferation of salivary adenoid cystic carcinoma.
  • Metastasis in salivary adenoid cystic carcinoma correlated with the expression of MPF.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Maturation-Promoting Factor / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17660907.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.11.22 / Maturation-Promoting Factor
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47. Lyons AJ, Xie JJ: Integrins in metastatic adenoid cystic carcinoma. Int J Oral Maxillofac Surg; 2005 Dec;34(8):912-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Integrins in metastatic adenoid cystic carcinoma.
  • Adenoid cystic carcinoma exhibits a diverse clinical behaviour from very localised invasion to widespread metastatases.
  • Recently two adenoid cystic carcinoma cells lines have been isolated and cultured which distinctly show either a low metastatic tendency (Acc-2) or a highly metastatic behaviour (Acc-M).
  • Adenoid cystic carcinoma cells of both types were obtained and successfully cultured.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / secondary. Integrins / biosynthesis. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / secondary

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  • (PMID = 16111868.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Integrins
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48. Freier K, Flechtenmacher C, Walch A, Devens F, Mühling J, Lichter P, Joos S, Hofele C: Differential KIT expression in histological subtypes of adenoid cystic carcinoma (ACC) of the salivary gland. Oral Oncol; 2005 Oct;41(9):934-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential KIT expression in histological subtypes of adenoid cystic carcinoma (ACC) of the salivary gland.
  • Adenoid cystic carcinoma (ACC) of the salivary gland is characterized by a prolonged but inevitably unfavorable clinical course.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Proto-Oncogene Proteins c-kit / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 16054424.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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49. Florentine BD, Fink T, Avidan S, Braslavsky D, Raza A, Cobb CJ: Extra-salivary gland presentations of adenoid cystic carcinoma: a report of three cases. Diagn Cytopathol; 2006 Jul;34(7):491-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-salivary gland presentations of adenoid cystic carcinoma: a report of three cases.
  • Adenoid cystic carcinoma (ACC) is a malignant neoplasm most commonly originating in salivary glands of the head and neck area.
  • When ACC presents outside of these locations, the diagnosis may become more challenging.
  • We describe three cases of ACC presenting in extra-salivary gland sites.
  • In conclusion, ACC can present in various body sites and cytologists must consider this neoplasm when presented with a basaloid carcinoma of uncertain origin.
  • [MeSH-major] Bone Neoplasms / secondary. Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Pleural Effusion / pathology

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16783770.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Schwarz S, Ettl T, Kleinsasser N, Hartmann A, Reichert TE, Driemel O: Loss of Maspin expression is a negative prognostic factor in common salivary gland tumors. Oral Oncol; 2008 Jun;44(6):563-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of Maspin expression is a negative prognostic factor in common salivary gland tumors.
  • The aim of the study was to analyze Maspin expression in salivary gland cancer as well as its prognostic impact on survival in comparison to clinical parameters.
  • Immunohistochemical staining was carried out in 73 cases of salivary gland malignancies.
  • High proportions of Maspin expression were observed in adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas ex pleomorphic adenoma, low proportions were seen in salivary duct carcinomas.
  • Analysis of the prognostic impact of Maspin expression was restricted to salivary gland carcinoma types of intermediate malignancy grade (adenoid cystic carcinoma, mucoepidermoid carcinoma and carcinoma ex pleomorphic adenoma).
  • According to these findings, Maspin might be useful as a new prognostic marker in adenoid cystic carcinoma and in salivary gland carcinomas with intermediate grade of malignancy where grading systems are still under debate.
  • [MeSH-major] Carcinoma, Mucoepidermoid / metabolism. Salivary Gland Neoplasms / metabolism. Serpins / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / mortality. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / mortality. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Prognosis. Serine Proteinase Inhibitors / pharmacology. Survival Rate. Young Adult

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  • (PMID = 17936671.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / SERPIN-B5; 0 / Serine Proteinase Inhibitors; 0 / Serpins; 0 / Tumor Suppressor Proteins
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51. Mücke T, Tannapfel A, Kesting MR, Wagenpfeil S, Robitzky LK, Wolff KD, Hölzle F: Adenoid cystic carcinomas of minor salivary glands. Auris Nasus Larynx; 2010 Oct;37(5):615-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinomas of minor salivary glands.
  • OBJECTIVES: Adenoid cystic carcinoma (ACC) is a very rare epithelioid tumor with different prognostic factors relating to overall survival.
  • MATERIALS AND METHODS: From 1992 to 2006, a total of 33 patients with ACC originating in minor salivary glands of the oral cavity were clinicopathologically reviewed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Neoplasm Recurrence, Local / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20181451.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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52. Qing J, Zhang Q, Wei MW, Guo ZM: [Prognostic analysis of adenoid cystic carcinoma of major salivary glands of 64 cases]. Ai Zheng; 2006 Sep;25(9):1138-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Prognostic analysis of adenoid cystic carcinoma of major salivary glands of 64 cases].
  • BACKGROUND & OBJECTIVE: Adenoid cystic carcinoma of salivary glands is a kind of highly malignant tumor, and researches on the tumors originated from major salivary glands are rare.
  • This study was to investigate prognostic factors of adenoid cystic carcinoma of major salivary glands.
  • METHODS: Clinical records of 64 patients with adenoid cystic carcinoma of major salivary glands followed up for more than 7 years were reviewed.
  • CONCLUSION: Presence or absence of nerve invasion, histological subtype, clinical stage, and positive or negative surgical margin are the independent factors affecting the prognosis of patients with adenoid cystic carcinoma of salivary glands.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Neoplasm Staging. Parotid Neoplasms / mortality. Parotid Neoplasms / pathology. Parotid Neoplasms / therapy. Prognosis. Radiotherapy, Adjuvant. Submandibular Gland Neoplasms / mortality. Submandibular Gland Neoplasms / pathology. Submandibular Gland Neoplasms / therapy. Survival Rate

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  • (PMID = 16965658.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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53. Luukkaa H, Laitakari J, Vahlberg T, Klemi P, Stenbäck F, Grénman R: Morphometric analysis of CD34-positive vessels in salivary gland adenoid cystic and mucoepidermoid carcinomas. J Oral Pathol Med; 2009 Oct;38(9):695-700
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphometric analysis of CD34-positive vessels in salivary gland adenoid cystic and mucoepidermoid carcinomas.
  • BACKGROUND: Carcinomas of the salivary glands are uncommon and morphologically a diverse group of malignancies.
  • To evaluate the prognostic value of CD34 immunostaining of the vessels in adenoid cystic carcinoma (AdCC) and mucoepidermoid carcinoma (MEC), an automated image analysis method was used.
  • METHOD: In a nationwide study, covering salivary gland cancer (SGC) patients in Finland 1991-1996, 37 AdCC and 18 MEC patients (M 25, F 30, age 25-90, mean 63) were included.
  • [MeSH-major] Antigens, CD34 / immunology. Carcinoma, Adenoid Cystic / blood supply. Carcinoma, Mucoepidermoid / blood supply. Image Processing, Computer-Assisted. Microvessels / immunology. Neovascularization, Pathologic / immunology. Salivary Gland Neoplasms / blood supply

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  • (PMID = 19674249.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34
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54. Visa L, Caballero M, Grau JJ: [Response to metronomic chemotherapy in a metastatic adenoid cystic carcinoma of the parotid gland]. Acta Otorrinolaringol Esp; 2010 Nov-Dec;61(6):452-4
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  • [Title] [Response to metronomic chemotherapy in a metastatic adenoid cystic carcinoma of the parotid gland].
  • [Transliterated title] Respuesta a quimioterapia metronómica en un carcinoma adenoide quístico metastásico de parótida.
  • Formerly, salivary gland cancer was considered to be chemoresistant.
  • Data on chemotherapy treatment for adenoid cystic carcinoma consist of phase II trials.
  • Our case report shows for first time the clinical activity of low-dose paclitaxel and cisplatin chemotherapy given separately as a single agent in metastatic adenoid cystic carcinoma of the parotid.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / secondary. Cisplatin / administration & dosage. Paclitaxel / administration & dosage. Parotid Neoplasms / drug therapy. Parotid Neoplasms / pathology

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  • [Copyright] Copyright © 2009 Elsevier España, S.L. All rights reserved.
  • (PMID = 20152955.001).
  • [ISSN] 1988-3013
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antineoplastic Agents; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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55. Singh S, Gokkulakrishnan, Jain J, Pathak S, Singh KT: Adenoid cystic carcinoma of buccal mucosa. J Maxillofac Oral Surg; 2010 Sep;9(3):273-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of buccal mucosa.
  • Adenoid cystic carcinoma is a malignant neoplasm most commonly originating in salivary glands of head and neck region.
  • Here we present a case report of a 50 year old male who was diagnosed with adenoid cystic carcinoma of the right buccal mucosa.

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  • (PMID = 22190804.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177452
  • [Keywords] NOTNLM ; Adenoid cystic / Carcinoma / Malignant neoplasm / Salivary gland disorder
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56. Till BG, Martins RG: Response to paclitaxel in adenoid cystic carcinoma of the salivary glands. Head Neck; 2008 Jun;30(6):810-4
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  • [Title] Response to paclitaxel in adenoid cystic carcinoma of the salivary glands.
  • BACKGROUND: Paclitaxel is not considered to be an active drug in adenoid cystic carcinoma (ACC) of the salivary glands.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Lung Neoplasms / drug therapy. Paclitaxel / therapeutic use. Salivary Gland Neoplasms / drug therapy

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  • (PMID = 17979110.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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57. Yang GC, Waisman J: Distinguishing adenoid cystic carcinoma from cylindromatous adenomas in salivary fine-needle aspirates: the cytologic clues and their ultrastructural basis. Diagn Cytopathol; 2006 Apr;34(4):284-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distinguishing adenoid cystic carcinoma from cylindromatous adenomas in salivary fine-needle aspirates: the cytologic clues and their ultrastructural basis.
  • The utilization of fine-needle aspiration (FNA) biopsy in salivary tumors is hindered by the reluctance of many cytopathologists to report adenoid cystic carcinoma (ACC) because its cylindromatous stroma is observed occasionally in pleomorphic adenoma (PA) and basal cell adenoma (BA), and a diagnosis of ACC results in radical surgery.
  • In conclusion, in our analysis of salivary tumors with a cylindromatous pattern, the seemingly naked nuclei of neoplastic cells with their coarse nuclear chromatin and irregular nucleoli, as revealed by the UFP stain, reliably distinguished ACC from cylindromatous adenomas.
  • [MeSH-major] Adenoma / pathology. Adenoma / ultrastructure. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / ultrastructure. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 16544336.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Qureshi SS, Nadkarni MS, Shrikhande SV, Desai S, Deodhar K, Ramadwar M, Shukla PJ: Hepatic resection for metastasis from adenoid cystic carcinoma of parotid gland. Indian J Gastroenterol; 2005 Jan-Feb;24(1):29-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic resection for metastasis from adenoid cystic carcinoma of parotid gland.
  • Adenoid cystic carcinoma is the commonest malignant tumor of the submandibular and minor salivary glands; the parotid gland constitutes a small share of this neoplasm.
  • We present a 30-year-old woman with solitary liver metastasis from an adenoid cystic carcinoma of the parotid gland, which had been surgically treated 10 years ago.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Parotid Neoplasms / pathology

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  • (PMID = 15778528.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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59. Cai Y, Wang R, Zhao YF, Jia J, Sun ZJ, Chen XM: Expression of Neuropilin-2 in salivary adenoid cystic carcinoma: its implication in tumor progression and angiogenesis. Pathol Res Pract; 2010 Dec 15;206(12):793-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of Neuropilin-2 in salivary adenoid cystic carcinoma: its implication in tumor progression and angiogenesis.
  • In the present study, to explore the expression and potential function of Nrp2 in salivary adenoid cystic carcinoma (SACC), immunohistochemistry was used to examine the Nrp2 expression in 50 SACCs and 20 normal salivary gland tissues nearby SACCs.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Neovascularization, Pathologic / metabolism. Neuropilin-2 / genetics. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20851535.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Blocking; 0 / Neuropilin-2
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60. Bobbio A, Copelli C, Ampollini L, Bianchi B, Carbognani P, Bettati S, Sesenna E, Rusca M: Lung metastasis resection of adenoid cystic carcinoma of salivary glands. Eur J Cardiothorac Surg; 2008 May;33(5):790-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lung metastasis resection of adenoid cystic carcinoma of salivary glands.
  • BACKGROUND: Adenoid cystic carcinoma is a rare tumour originating from the exocrine mucous glands, known for its high propensity for distant metastases.
  • The value of lung metastasis resection from adenoid cystic carcinoma of salivary glands origin is evaluated.
  • METHODS: A retrospective study was conducted on patients undergoing surgery for primary adenoid cystic carcinoma of the salivary glands between 1982 and 2006.
  • RESULTS: Twenty-six men and 24 women with a median age of 57 years (range 33-79) underwent radical surgery for adenoid cystic carcinoma during the study period.
  • CONCLUSIONS: Patients with adenoid cystic carcinoma could be frequently encountered with disease recurrence confined to the lung.
  • [MeSH-major] Lung Neoplasms / secondary. Lung Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / secondary. Carcinoma, Adenoid Cystic / surgery. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Linear Models. Male. Middle Aged. Retrospective Studies. Survival Rate

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  • (PMID = 18343149.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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61. Chen W, Zhang HL, Shao XJ, Jiang YG, Zhao XG, Gao X, Li JH, Yang J, Zhang YF, Liu BL, Sun MY: Gene expression profile of salivary adenoid cystic carcinoma associated with perineural invasion. Tohoku J Exp Med; 2007 Jul;212(3):319-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene expression profile of salivary adenoid cystic carcinoma associated with perineural invasion.
  • Adenoid cystic carcinoma (ACC) is a common salivary gland malignancy characterized by slow but progressive clinical course, proclivity for hematogenous spread and perineural invasion (PNI) that exhibits inherent resistance to complete surgical resection, systemic chemotherapy and conventional radiotherapy.
  • We report the combined use of laser capture microdissection (LCM) and high-throughput cDNA microarray to monitor in vivo gene expression profile of salivary ACC and to correlate the profile with PNI.
  • Pure cancer cells adjacent to the nerve tracts from 6 cancerous tissues judged as PNI were laser captured, and pure cancer cells from the same 6 tumors distant from the nerve tracts were also procured.
  • As to the result of 6 arrays, a total of 53 genes were identified as being 2-fold or more differentially expressed in PNI cancer cell group as compared to non-PNI cancer cell control.
  • The combined use of LCM and cDNA microarray analysis provides a powerful new approach to monitor the in vivo molecular events of PNI in salivary ACC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Gene Expression Profiling. Peripheral Nervous System Neoplasms / genetics. Peripheral Nervous System Neoplasms / pathology. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 17592219.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] Japan
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62. Shi J, Wang S, Zhao E, Shi L, Xu X, Fang M: Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma. J Oral Pathol Med; 2010 Aug 1;39(7):548-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma.
  • AIMS: To investigate the relationship between paxillin expression and clinicopathological features and metastasis in salivary adenoid cystic carcinoma (SACC).
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Paxillin / analysis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Coloring Agents. Cytoplasm / ultrastructure. Extracellular Space. Female. Histocytochemistry. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Parotid Neoplasms / pathology. Salivary Glands, Minor / pathology. Submandibular Gland Neoplasms / pathology. Young Adult

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  • (PMID = 20136697.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / PXN protein, human; 0 / Paxillin
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63. Li MH, Zhang GZ, Wang YS: [Effect of salidroside on salivary adenoid cystic carcinoma cells in vitro]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2008 Jun;26(3):312-5, 319
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  • [Title] [Effect of salidroside on salivary adenoid cystic carcinoma cells in vitro].
  • OBJECTIVE: To study the effect and mechanism of salidroside on salivary adenoid cystic carcinoma (SACC-2) cells in vitro.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Salivary Gland Neoplasms

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  • (PMID = 18705520.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glucosides; 0 / Phenols; 10338-51-9 / rhodioloside
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64. Zhang CY, Zhou XJ, Zhang ZY, Li J: [DNA methylation in salivary adenoid cystic carcinoma cell lines]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2007 Mar;42(3):135-9
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  • [Title] [DNA methylation in salivary adenoid cystic carcinoma cell lines].
  • OBJECTIVE: To investigate the promoter methylation status of tumor suppressor gene and the relationship between promoter methylation and mRNA, protein expression of tumor suppressor gene in salivary adenoid cystic carcinoma (ACC) cell lines.
  • RESULTS: All the three salivary ACC cell lines exhibited E-cad, p16 promoter methylation, but no methylation of RASSF1A, DAPK, and MGMT was found.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. DNA Methylation. Salivary Gland Neoplasms / genetics

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  • (PMID = 17565817.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cadherins; 0 / Neoplasm Proteins; 0 / P16 protein, human
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65. Ferrazzo KL, Alves SM Jr, Santos E, Martins MT, de Sousa SM: Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. Oral Oncol; 2007 Jul;43(6):580-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands.
  • Adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA) are malignant neoplasms of salivary glands, which are similar in histologic patterns but very different in clinical behavior, treatment and prognosis.
  • This protein was found to be implicated in cellular transformation and a correlation between its expression and cancer progression and metastasis has been described.
  • Moreover, slides of normal salivary glands were included.
  • In normal salivary glands there was strong nuclear and cytoplasmic staining for galectin-3 in ductal luminal cells.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Galectin 3 / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / pathology

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  • (PMID = 16996782.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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66. Zhang B, Guan CC, Chen WT, Zhang P, Yan M, Shi JH, Qin CL, Yang Q: A20 inhibits human salivary adenoid cystic carcinoma cells invasion via blocking nuclear factor-kappaB activation. Chin Med J (Engl); 2007 Oct 20;120(20):1830-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A20 inhibits human salivary adenoid cystic carcinoma cells invasion via blocking nuclear factor-kappaB activation.
  • Several studies have implicated that the NF-kappaB signal pathway is associated with angiogenesis and clinico-pathological process of adenoid cystic carcinoma (ACC) of the salivary glands.
  • CONCLUSIONS: A20 gene transfer is associated with decreased tumor invasion, in part via the down-regulation of NF-kappaB expression, providing evidence for a potential application of A20 in designing a treatment modality for salivary gland cancers such as ACC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Genetic Therapy. Intracellular Signaling Peptides and Proteins / genetics. NF-kappa B / antagonists & inhibitors. Nuclear Proteins / genetics. Salivary Gland Neoplasms / therapy

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  • (PMID = 18028781.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / NF-kappa B; 0 / Nuclear Proteins; EC 6.3.2.19 / TNFAIP3 protein, human
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67. Ding LC, She L, Zheng DL, Huang QL, Wang JF, Zheng FF, Lu YG: Notch-4 contributes to the metastasis of salivary adenoid cystic carcinoma. Oncol Rep; 2010 Aug;24(2):363-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Notch-4 contributes to the metastasis of salivary adenoid cystic carcinoma.
  • The aim of the present study was to identify the role of Notch protein in the metastasis of salivary adenoid cystic carcinoma (SACC).
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Proto-Oncogene Proteins / physiology. Receptors, Notch / physiology. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 20596622.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / NOTCH4 protein, human; 0 / Proto-Oncogene Proteins; 0 / RNA, Small Interfering; 0 / Receptors, Notch
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68. Xue F, Zhang Y, Liu F, Jing J, Ma M: Expression of IgSF in salivary adenoid cystic carcinoma and its relationship with invasion and metastasis. J Oral Pathol Med; 2005 May;34(5):295-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of IgSF in salivary adenoid cystic carcinoma and its relationship with invasion and metastasis.
  • BACKGROUND: The aim of the present work was to study the potential effect of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and neural cell adhesion molecule (NCAM) of immunoglobulin superfamily on the invasion and metastasis of salivary adenoid cystic carcinoma (SACC).
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Intercellular Adhesion Molecule-1 / biosynthesis. Neural Cell Adhesion Molecules / metabolism. Salivary Gland Neoplasms / metabolism. Vascular Cell Adhesion Molecule-1 / biosynthesis

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  • (PMID = 15817073.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / IGSF1 protein, human; 0 / Immunoglobulins; 0 / Membrane Proteins; 0 / Neural Cell Adhesion Molecules; 0 / Vascular Cell Adhesion Molecule-1; 126547-89-5 / Intercellular Adhesion Molecule-1
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69. Deshpande AH, Kelkar AA: Hepatic metastasis as an initial manifestation of salivary adenoid cystic carcinoma: Cytologic diagnosis. Diagn Cytopathol; 2009 Jan;37(1):45-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic metastasis as an initial manifestation of salivary adenoid cystic carcinoma: Cytologic diagnosis.
  • Adenoid cystic carcinoma is a malignant tumor of the salivary glands.
  • We present the case of a 68-year-old male with complaints and radiological findings suggestive of primary hepatocellular carcinoma.
  • However, fine-needle aspiration findings showed metastasis of adenoid cystic carcinoma.
  • A retrospective clinical and ultrasound examination of the patient revealed a small asymptomatic enlargement of the submandibular salivary gland that was aspirated and showed features of adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Liver Neoplasms / secondary. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Humans. Male. Submandibular Gland / pathology. Submandibular Gland / ultrasonography. Tomography, X-Ray Computed

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18973128.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Tang Y, Liang X, Zheng M, Zhu Z, Zhu G, Yang J, Chen Y: Expression of c-kit and Slug correlates with invasion and metastasis of salivary adenoid cystic carcinoma. Oral Oncol; 2010 Apr;46(4):311-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of c-kit and Slug correlates with invasion and metastasis of salivary adenoid cystic carcinoma.
  • The overexpression of c-kit seems to be frequent and specific in salivary adenoid cystic carcinoma (ACC), however, there is little information on correlation between c-kit expression and the invasion and metastasis.
  • Recently, the data showed that Slug, a transcription factor of epithelial-mesenchymal transitions (EMT), is a molecular target that contributes to the biological specificity of c-kit signaling pathway.
  • In this study, the expression of c-kit and Slug was evaluated in two ACC cell lines and 121 patients with ACC.
  • The immunohistochemical assay in patients demonstrated that positive expression of c-kit and Slug was observed in 108/121 (89.26%) and 87/121 (71.90%) of cases, respectively, and that c-kit and Slug expression was significantly associated with tumor site, TNM stage, histological pattern, perineural invasion, local regional recurrence and distant metastasis of patients with ACC (P<0.05).
  • Furthermore, there was a significant association between the positive expression of c-kit and that of Slug (P=0.046).
  • These findings indicated that c-kit/Slug pathway might participate in the invasion and metastasis of salivary ACC.
  • [MeSH-major] Adenocarcinoma. Carcinoma, Adenoid Cystic. Neoplasm Proteins / metabolism. Proto-Oncogene Proteins c-kit / metabolism. Salivary Gland Neoplasms. Transcription Factors / metabolism

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20219417.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Transcription Factors; 0 / snail family transcription factors; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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71. He H, Tang X, Li L, Li L, Hua C, He D: [Effect of mechanical stimulation on the invasion in salivary adenoid cystic carcinoma]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2007 Oct;24(5):1065-8, 1088
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effect of mechanical stimulation on the invasion in salivary adenoid cystic carcinoma].
  • This study was aimed to assess the effects of cyclic biaxial mechanical stimulation on the invasion capacity in vitro and on the expression of MMP-9 in the salivary adenoid cystic carcinoma (SACC) high metastatic cell lines ACC-M, and in the SACC low metastatic cell lines ACC-2.
  • It can promote metastasis of the cancer.
  • Moreover, some protein other than MMP-9 may play an important role in the metastasis of the cancer.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Matrix Metalloproteinase 9 / metabolism. Salivary Gland Neoplasms / pathology. Stress, Mechanical

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  • (PMID = 18027698.001).
  • [ISSN] 1001-5515
  • [Journal-full-title] Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
  • [ISO-abbreviation] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.4.24.35 / Matrix Metalloproteinase 9
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72. Ross PJ, Teoh EM, A'hern RP, Rhys-Evans PH, Harrington KJ, Nutting CM, Gore ME: Epirubicin, cisplatin and protracted venous infusion 5-Fluorouracil chemotherapy for advanced salivary adenoid cystic carcinoma. Clin Oncol (R Coll Radiol); 2009 May;21(4):311-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epirubicin, cisplatin and protracted venous infusion 5-Fluorouracil chemotherapy for advanced salivary adenoid cystic carcinoma.
  • AIMS: Adenoid cystic carcinoma (ACC) is a rare tumour that usually arises in the salivary glands.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Salivary Gland Neoplasms / drug therapy

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  • (PMID = 19201585.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antimetabolites, Antineoplastic; 3Z8479ZZ5X / Epirubicin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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73. Lai FY, Zhang Q, Wu QL, Qing J, Cao Y: [Expression and significance of E-cadherin in adenoid cystic carcinoma of the salivary glands]. Ai Zheng; 2007 Sep;26(9):1025-8
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  • [Title] [Expression and significance of E-cadherin in adenoid cystic carcinoma of the salivary glands].
  • This study was to explore the expression of E-cadherin in adenoid cystic carcinoma of the salivary glands and its correlations to nerve invasion, regional recurrence, distant metastasis and prognosis of this disease.
  • METHODS: The expression of E-cadherin in 55 specimens of adenoid cystic carcinoma of the salivary glands and 20 specimens of normal salivary gland tissue was detected by immunohistochemistry.
  • The positive rate of E-cadherin was significantly higher in normal salivary gland tissues than in adenoid cystic carcinoma tissues (90.0% vs.63.6%, P<0.05).
  • CONCLUSION: E-cadherin expression is down-regulated in adenoid cystic carcinoma of the salivary glands, which is correlated to nerve invasion, regional recurrence and distant metastasis.
  • [MeSH-major] Cadherins / metabolism. Carcinoma, Adenoid Cystic / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Cranial Nerve Neoplasms / pathology. Facial Nerve Diseases / pathology. Female. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Salivary Glands / metabolism. Salivary Glands / surgery. Survival Rate

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  • (PMID = 17927866.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cadherins
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74. Triantafillidou K, Dimitrakopoulos J, Iordanidis F, Koufogiannis D: Management of adenoid cystic carcinoma of minor salivary glands. J Oral Maxillofac Surg; 2006 Jul;64(7):1114-20
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  • [Title] Management of adenoid cystic carcinoma of minor salivary glands.
  • PURPOSE: Adenoid cystic carcinoma (ACC) is a rare malignant tumor originating from the salivary glands.
  • METHODS: Between 1985 and 2000, 22 patients with ACC of minor salivary glands were treated in the Clinic of Oral and Maxillofacial Surgery of the "G.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / surgery. Ki-67 Antigen / metabolism. Salivary Gland Neoplasms / surgery

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  • (PMID = 16781345.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
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75. Liang S, Fan M: Immunotherapy for adenoid cystic carcinoma of salivary glands: cancer/testis antigens and 5-aza-2'-deoxycytidine. Med Hypotheses; 2009 Nov;73(5):768-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunotherapy for adenoid cystic carcinoma of salivary glands: cancer/testis antigens and 5-aza-2'-deoxycytidine.
  • Adenoid cystic carcinoma of salivary glands is the epithelial tumor.
  • There are amount of malignant occurrences of adenoid cystic carcinoma of salivary glands in the head and neck area.
  • Cancer/testis antigens can be found in various malignant tumors, normal adult testis and occasionally placenta, but not in the other normal adult tissues.
  • This characteristic makes Cancer/testis antigens as potential markers to be applied in immunotherapeutic strategies against cancer.
  • It has been shown that in different tumors, the expression of certain Cancer/testis antigens is activated treated with 5-aza-CdR via the demethylation of their promoter CpG islands.
  • It is logical that multiple Cancer/testis antigens may correlate with the clinicopathologic factors of adenoid cystic carcinoma of salivary glands and be the potential markers of prognosis treated with 5-aza-CdR.
  • So the hypothesis will provide the new direction that we can use Cancer/testis antigens as candidate antigens for adenoid cystic carcinoma of salivary glands immunotherapy due to the high expression rate activated with 5-aza-CdR.
  • [MeSH-major] Antigens, Neoplasm / immunology. Carcinoma, Adenoid Cystic / therapy. Immunotherapy. Salivary Gland Neoplasms / therapy. Testis / immunology

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  • (PMID = 19481355.001).
  • [ISSN] 1532-2777
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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76. He JF, Ge MH, Zhu X, Chen C, Tan Z, Li YN, Gu ZY: Expression of RUNX3 in salivary adenoid cystic carcinoma: implications for tumor progression and prognosis. Cancer Sci; 2008 Jul;99(7):1334-40
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  • [Title] Expression of RUNX3 in salivary adenoid cystic carcinoma: implications for tumor progression and prognosis.
  • Runt-related transcription factor-3 (RUNX3), being a tumor suppressor gene in gastric cancer, plays an important role in inhibiting cellular growth by participating in the transforming growth factor-beta-dependent apoptosis.
  • The aim of this study was to determine the expression of RUNX3 in normal salivary glands and adenoid cystic carcinomas (ACCs), comparing the results with clinicopathological factors and patient survival.
  • The quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis and Western blot analysis revealed the expression of RUNX3 both in normal salivary glands and ACCs.
  • Nuclear and cytoplasmic immunoreactivities against RUNX3 in ductal luminal cells and acinous cells, but immunonegative in myoepithelial cells, were detected in normal salivary glands.
  • Our results demonstrate the expression of RUNX3 in normal salivary glands and salivary ACCs.
  • The low level of RUNX3 protein in salivary ACCs might play a pivotal role in tumor progression and have prognostic values in ACCs.
  • [MeSH-major] Carcinoma, Adenoid Cystic / chemistry. Core Binding Factor Alpha 3 Subunit / analysis. Salivary Gland Neoplasms / chemistry
  • [MeSH-minor] Blotting, Western. Cytoplasm / chemistry. Disease Progression. Humans. Immunohistochemistry. Middle Aged. Prognosis. Reverse Transcriptase Polymerase Chain Reaction. Salivary Glands / chemistry. Transforming Growth Factor beta / pharmacology

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  • (PMID = 18410404.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 3 Subunit; 0 / Runx3 protein, human; 0 / Transforming Growth Factor beta
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77. Ciccolallo L, Licitra L, Cantú G, Gatta G, EUROCARE Working Group: Survival from salivary glands adenoid cystic carcinoma in European populations. Oral Oncol; 2009 Aug;45(8):669-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival from salivary glands adenoid cystic carcinoma in European populations.
  • Adenoid cystic carcinoma (ACC) of salivary gland origin is rare.
  • The EUROCARE data provide a good opportunity to study the survival of this uncommon cancer in a large population.
  • A total of 2611 cases, aged 15 to 99 years, diagnosed between 1983 and 1994 with primary salivary gland ACC were analyzed.
  • Thirty-two population based cancer registries from seventeen countries participating in EUROCARE contributed the data.
  • Relative survival by sex, age, period of diagnosis, region, site and stage, and the adjusted relative excess risk (RER) of death were estimated.
  • Survival since diagnosis was 94%, 78% and 65% at 1, 5 and ten years, respectively.
  • A strong effect of stage at diagnosis on RERs and some worsening of survival at five years over time (80% in 1983-1985, 76% in 1992-1994) were also evident.
  • The findings of the present study, as those from clinical studies, confirm the important impact of primary site and stage at diagnosis on survival.
  • [MeSH-major] Carcinoma, Adenoid Cystic / mortality. Rare Diseases / mortality. Salivary Gland Neoplasms / mortality

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  • (PMID = 19095489.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Investigator] Oberaigner W; Storm HH; Aareleid T; Jechova M; Rousarova M; Hakulinen T; Hédelin G; Tron I; Le Gall E; Launoy G; Macé-Lesec'h J; Faivre J; Chaplain G; Carli PM; Danzon A; Tretarre B; Colonna M; Lacour B; Raverdy N; Berger C; Freycon B; Grosclaude P; Estève J; Kaatsch P; Ziegler H; Hölzel D; Schubert Fritschle G; Tryggvadottir L; Berrino F; Allemani C; Baili P; Ciccolallo L; Crosignani P; Gatta G; Micheli A; Sant M; Taussig E; Sowe S; Ferretti S; Conti E; Vercelli M; Quaglia A; Pannelli F; Federico M; Artioli ME; Ponz De Leon M; Benatti P; De Lisi V; Servente L; Zanetti R; Patriarca S; Magnani C; Pastore G; Gafa L; Tumino R; Falcini F; Budroni M; Paci E; Crocetti E; Zambon P; Guzzinati S; Capocaccia R; Carrani E; De Angelis R; Roazzi P; Santaquilani M; Tavilla A; Valente F; Verdecchia A; Dalmas M; Langmark F; Andersen A; Rachtan J; Bielska-Lasota M; Wronkowski Z; Plesko I; Obsitníková A; Pompe-Kirn V; Primic Zakelj M; Izarzugaza I; Martinez-Garcia C; Garau I; Navarro C; Chirlaque MD; Ardanaz E; Moreno C; Galceran J; Torrella A; Peris-Bonet R; Barlow L; Möller L; Jundt G; Lutz JM; Bouchardy C; Coebergh JW; Visser O; Godward S; Coleman MP; Williams EM; Forman D; Quinn MJ; Roche M; Edwards S; Stiller C; Verne J; Møller H; Bell J; Botha JL; Lawrence G; Black R; Steward JA
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78. Sun MY, Chen W, Yang LJ, Dong SZ: [Coexpression of Schwann cell marker GFAP and myoepithelial cell marker alpha-SMA in salivary adenoid cystic carcinoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2006 Aug;41(8):461-3
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Coexpression of Schwann cell marker GFAP and myoepithelial cell marker alpha-SMA in salivary adenoid cystic carcinoma].
  • OBJECTIVE: To observe the expression of Schwann cell marker GFAP and myoepithelial cell marker alpha-SMA in salivary adenoid cystic carcinoma (ACC), and to evaluate the relationship of GFAP, alpha-SMA and perineural invasion in ACC.
  • METHODS: Immunohistochemical SABC method, double-label immunofluorescence and CLSM were used to detect the expression of GFAP and alpha-SMA proteins in salivary ACC tissue samples.
  • RESULTS: In salivary ACC tissue samples, both GFAP and alpha-SMA proteins were positive, which were coexpressed in cytoplasm of the same onco-myoepithelial cells.
  • CONCLUSIONS: There may be Schwann cell differentiation in onco-myoepithelial cell of salivary ACC, and it may be the pathological base of perineural invasion in salivary ACC.
  • [MeSH-major] Actins / metabolism. Carcinoma, Adenoid Cystic / metabolism. Epithelial Cells / metabolism. Glial Fibrillary Acidic Protein / metabolism. Muscle Cells / metabolism. Salivary Gland Neoplasms / metabolism. Schwann Cells / metabolism

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  • (PMID = 17074178.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Glial Fibrillary Acidic Protein
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79. Saito M, Nishiyama H, Maruyama S, Oda Y, Saku T, Hayashi T: Adenoid cystic carcinoma of sublingual gland involving the submandibular duct. Dentomaxillofac Radiol; 2008 Oct;37(7):421-4
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  • [Title] Adenoid cystic carcinoma of sublingual gland involving the submandibular duct.
  • We report an unusual case of adenoid cystic carcinoma (ACC) arising in the sublingual gland and extending into the submandibular duct.
  • The findings indicated that the cystic space of the posterior part was filled with tumour mass which extended from the anterior part.
  • ACC of the sublingual gland extending into the submandibular duct is rare and the MR findings have not been previously described in the literature.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Sublingual Gland Neoplasms / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Humans. Magnetic Resonance Imaging. Male. Salivary Ducts / pathology

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  • (PMID = 18812607.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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80. Ma J, Zhong M, Wang ZY: [Anti-proliferation effect of genistein on salivary adenoid cystic carcinoma cell line SACC-83 in vitro]. Shanghai Kou Qiang Yi Xue; 2005 Feb;14(1):55-8
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  • [Title] [Anti-proliferation effect of genistein on salivary adenoid cystic carcinoma cell line SACC-83 in vitro].
  • PURPOSE: To investigate the anti-proliferation effect of tyrosine protein kinase inhibitor, genistein (4'-5,7-trihydroxyisoflavone), on human salivary adenoid cystic carcinoma cell line SACC-83 in vitro, and its effect on cell cycle.
  • CONCLUSION: Genistein inhibits growth of human salivary adenoid cystic carcinoma cell line SACC-83, arrests cell cycle in G2/M phase, and induces cell apoptosis; these suggest that tyrosine protein kinase has important effect on the neoplasia and development of salivary adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Cell Proliferation / drug effects. Genistein / pharmacology. Salivary Gland Neoplasms / pathology


81. Ma J, Zong ZH, Wang ZY, Zhong M: [Effects of Genistein on the proliferation and expression of survivin in salivary adenoid cystic carcinoma cell line SACC-83]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2007 Feb;25(1):97-9
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  • [Title] [Effects of Genistein on the proliferation and expression of survivin in salivary adenoid cystic carcinoma cell line SACC-83].
  • OBJECTIVE: To investigate the anti-proliferation effect of tyrosine protein kinase inhibitor, Genistein, on human salivary adenoid cystic carcinoma cell line SACC-83, and its effect on Survivin expression.
  • CONCLUSION: Genistein inhibits the growth of human salivary adenoid cystic carcinoma cell line SACC-83, and induces cell apoptosis; the decrease of Survivin expression may be one of the mechanisms of Genistein inducing apoptosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Genistein
  • [MeSH-minor] Apoptosis. Cell Line. Cell Line, Tumor. Cell Proliferation. Humans. Salivary Gland Neoplasms

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  • (PMID = 17375591.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] DH2M523P0H / Genistein
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82. Papadogeorgakis N, Kalfarentzos EF, Vourlakou C, Malta F, Exarhos D: Simultaneous pleomorphic adenoma of the left parotid gland and adenoid cystic carcinoma of the contralateral sublingual salivary gland: a case report. Oral Maxillofac Surg; 2009 Dec;13(4):221-4
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  • [Title] Simultaneous pleomorphic adenoma of the left parotid gland and adenoid cystic carcinoma of the contralateral sublingual salivary gland: a case report.
  • INTRODUCTION: Sublingual salivary gland neoplasms are extremely rare, accounting for only 0.3-1% of all epithelial salivary gland tumors.
  • Most of the sublingual tumors are malignant, adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) being the most common histological types.
  • The coexistence of two salivary gland tumors located in different major salivary glands is uncommon.
  • CASE REPORT: A rare case of two simultaneous tumors of the major salivary glands, one in the sublingual and the other in the contralateral parotid gland in a female patient is reported.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Sublingual Gland Neoplasms / pathology

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  • (PMID = 19690903.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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83. Bianchi B, Copelli C, Cocchi R, Ferrari S, Pederneschi N, Sesenna E: Adenoid cystic carcinoma of intraoral minor salivary glands. Oral Oncol; 2008 Nov;44(11):1026-31
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of intraoral minor salivary glands.
  • We present a retrospective multicentric study of 67 patients with adenoid cystic carcinomas of the intraoral minor salivary glands, who were diagnosed and treated between 1986 and 2004 in the Operative Units of Maxillofacial Surgery of the University of Parma and of the Bellaria Hospital in Bologna.
  • [MeSH-major] Carcinoma, Adenoid Cystic / mortality. Neoplasm Recurrence, Local / mortality. Salivary Gland Neoplasms / mortality. Salivary Glands, Minor

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  • (PMID = 18396442.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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84. Mithani SK, Shao C, Tan M, Smith IM, Califano JA, El-Naggar AK, Ha PK: Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. PLoS One; 2009 Dec 30;4(12):e8493
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands.
  • No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas.
  • METHODOLOGY: The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was sequenced to determine the frequency and distribution of mitochondrial mutations in ACC tumors.
  • CONCLUSIONS/SIGNIFICANCE: Mitochondrial mutation is frequent in salivary ACCs.

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  • (PMID = 20041111.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P20 CA118782; United States / NIDCR NIH HHS / DE / K08DE018463; United States / NIDCR NIH HHS / DE / R01 DE015939; United States / NIDCR NIH HHS / DE / 9P50DE019032; United States / NIDCR NIH HHS / DE / 1R01DE015939; United States / NCI NIH HHS / CA / 5P20CA118782; United States / NIDCR NIH HHS / DE / P50 DE019032; United States / NIDCR NIH HHS / DE / K08 DE018463
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acids; 0 / DNA, Mitochondrial; 0U46U6E8UK / NAD
  • [Other-IDs] NLM/ PMC2795173
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85. Whitt JC, Schafer DR, Callihan MD: Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth. Head Neck Pathol; 2008 Mar;2(1):41-8
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth.
  • Salivary gland tumors usually occur as single lesions.
  • We report a case of an adult male who presented with a mucoepidermoid carcinoma involving the minor salivary glands of the palate at age 57 years, followed by an adenoid cystic carcinoma of the floor of mouth at age 63 years.
  • There are 31 acceptable cases of multiple malignant salivary gland neoplasms reported in the world literature.
  • Bilateral acinic cell adenocarcinoma was the most frequent combination of multiple salivary gland malignancy, accounting for 14 cases (10 synchronous and four metachronous).
  • All involved the parotid glands bilaterally with the exception of one case that involved parotid and submandibular gland.
  • Polymorphous low-grade adenocarcinoma accounted for three of the four cases of multiple malignant tumors involving minor salivary glands.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Mouth Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Palatal Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 20614341.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807610
  • [Keywords] NOTNLM ; Metachronous neoplasms / Multiple malignant salivary gland neoplasms / Salivary gland neoplasms / Salivary gland tumors / Synchronous neoplasms
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86. Beltran D, Faquin WC, Gallagher G, August M: Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma. J Oral Maxillofac Surg; 2006 Mar;64(3):415-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma.
  • PURPOSE: Polymorphous low-grade adenocarcinoma (PLGA) is a salivary gland malignancy characterized by indolent growth and a low rate of metastasis.
  • PLGA shares histological features with adenoid cystic carcinoma (ACC), including infiltrating solid and cribriform patterns, presence of cystic spaces, and neurotropism.
  • This study examines the potential use of c-kit, Ki-67, smooth muscle actin (SMA), and muscle-specific actin (MSA) as ancillary markers for distinguishing PLGA from ACC.
  • RESULTS: PLGA showed a significantly weaker immunohistochemical expression of c-kit compared with ACC (P = < .001).
  • CONCLUSIONS: Statistically significant immunohistochemical staining patterns using c-kit and SMA in this study support their potential use as markers to differentiate PLGA from ACC in cases where the diagnosis can be challenging.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. Salivary Gland Neoplasms / chemistry. Salivary Gland Neoplasms / classification
  • [MeSH-minor] Actins / analysis. Adult. Aged. Aged, 80 and over. Cytoskeletal Proteins / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Muscle Proteins / analysis. Neoplasm Proteins / analysis. Proto-Oncogene Proteins c-kit / analysis. Statistics, Nonparametric

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  • (PMID = 16487803.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Ki-67 Antigen; 0 / Muscle Proteins; 0 / Neoplasm Proteins; 0 / Smooth muscle protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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87. Liu X, Zhang Y, Ren W, Rao G: erbB2 gene silencing and its effect on PTEN in SACC-83 salivary adenoid cystic carcinoma cells. Oncol Rep; 2010 Nov;24(5):1291-6
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  • [Title] erbB2 gene silencing and its effect on PTEN in SACC-83 salivary adenoid cystic carcinoma cells.
  • erbB2 gene plays an important role in carcinoma formation. erbB2 overexpression was observed in many types of tumours, including salivary carcinoma.
  • However, a putative erbB2 and PTEN interaction remains largely unknown in salivary adenoid cystic carcinoma cells.
  • The purpose of this study was to silence erbB2 gene and investigate the functional relationship between erbB2 and PTEN in SACC-83 salivary adenoid cystic carcinoma cells. erbB2-specific siRNAs were transfected into SACC-83 cells using cationic liposome.
  • Future studies will more closely examine the molecular and biological relationships of erbB2 and PTEN in salivary adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Gene Silencing. Genes, erbB-2. PTEN Phosphohydrolase / biosynthesis. Salivary Gland Neoplasms / genetics

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  • (PMID = 20878123.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Small Interfering; EC 2.7.10.1 / Receptor, ErbB-2; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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88. Shen L, Sun CF: [The expression of PTEN and PKB in salivary adenoid cystic carcinoma and its clinical significance]. Shanghai Kou Qiang Yi Xue; 2005 Apr;14(2):159-63
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  • [Title] [The expression of PTEN and PKB in salivary adenoid cystic carcinoma and its clinical significance].
  • PURPOSE: To investigate the expression of PTEN and PKB in salivary adenoid cystic carcinoma (SACC) and its clinical significance.
  • RESULTS: In 38 cases, both non-cancer tissue near by cancer and cancer tissue, 21 (55.26%) cases cancer tissue PTEN expression positive were found, 32 (84.21%) cases the non-cancer tissue near by cancer PTEN expression positive were found.
  • There was significant difference in cancer tissue and non-cancer tissue near by cancer (P<0.05).
  • 31 (81.58%) cases cancer tissue PKB expression positive were found, 20 (52.63%) cases the non-cancer tissue near by cancer PKB expression positive were found.
  • There was significant difference in cancer tissue and non-cancer tissue near by cancer (P<0.01).
  • CONCLUSIONS: The expression of PTEN and PKB may be related to the occurrence and progress of salivary adenoid cystic carcinoma,PTEN and PKB may have effect on metastasis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. PTEN Phosphohydrolase / genetics. Salivary Gland Neoplasms / metabolism


89. Mosqueda-Taylor A, Cano-Valdéz AM, Ruiz-González JD, Ortega-Gutiérrez C, Luna-Ortiz K: Hybrid salivary gland tumor of the upper lip or just an adenoid cystic carcinoma? Case report. Med Oral Patol Oral Cir Bucal; 2010 Jan;15(1):e43-7
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

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  • [Title] Hybrid salivary gland tumor of the upper lip or just an adenoid cystic carcinoma? Case report.
  • A 65 year-old male patient with a one year-duration tumoral growth located in the upper lip was diagnosed on incisional biopsy as epithelial-myoepithelial carcinoma.
  • After wide surgical excision the histopathological analysis revealed the lesion was composed predominantly (>90%) of adenoid cystic carcinoma.
  • In new sections it was found a very small and isolated area of adenoid cystic carcinoma at the bottom of the incisional biopsy.
  • The lesion was surgically removed and a histopathological diagnosis of neurocysticercosis was rendered.
  • CONCLUSION: True hybrid tumors of salivary glands are rare and treatment in each case should be done according to the component with the higher aggressiveness.
  • However, the occurrence of epithelial-myoepithelial carcinoma areas within an adenoid cystic carcinoma seems to be a frequent finding, and because both lesions share a common origin, some authors consider that this may not be a true hybrid neoplasm but a variant of the latter.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lip Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 19680176.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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90. Shi H, Wang J, Dong F, Wang X, Li H, Hou Y: The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma. BMC Cancer; 2009;9:456
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma.
  • BACKGROUND: Salivary adenoid cystic carcinoma (SACC) is one of the most common malignancies of salivary gland.
  • [MeSH-major] Carcinoma, Adenoid Cystic / drug therapy. Pentosyltransferases / antagonists & inhibitors. Proteoglycans / antagonists & inhibitors. RNA, Small Interfering / pharmacology. Salivary Gland Neoplasms / drug therapy

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  • (PMID = 20025737.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Proteoglycans; 0 / RNA, Small Interfering; EC 2.4.2.- / Pentosyltransferases; EC 2.4.2.26 / UDP xylose-protein xylosyltransferase
  • [Other-IDs] NLM/ PMC2805682
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91. Xie W, Li X, Ren G, Guo W: Expression and importance of inhibitor of DNA binding helix-loop-helix protein in salivary adenoid cystic carcinoma. Br J Oral Maxillofac Surg; 2010 Sep;48(6):434-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and importance of inhibitor of DNA binding helix-loop-helix protein in salivary adenoid cystic carcinoma.
  • However, the role of Id-1 protein in salivary adenoid cystic carcinoma (ACC) is not clear.
  • Thirty-nine of the 54 specimens of ACC stained for Id-1expression, which was significantly more than was found in pleomorphic adenomas (4/12) and normal salivary gland tissues (1/10, p<0.05).
  • Our results showed that Id-1 may have important roles in the development of salivary ACC.
  • It might also be a useful therapeutic tool to help prevent salivary ACC or to inhibit its malignant progression.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Gene Expression Regulation, Neoplastic. Inhibitor of Differentiation Protein 1 / biosynthesis. Salivary Gland Neoplasms / metabolism

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  • [Copyright] Copyright 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19766362.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Inhibitor of Differentiation Protein 1
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92. Ide F, Mishima K, Yamada H, Saito I: Adenoid cystic carcinoma ex pleomorphic adenoma of the parotid gland. Head Neck Pathol; 2009 Jun;3(2):159-62
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  • [Title] Adenoid cystic carcinoma ex pleomorphic adenoma of the parotid gland.
  • There is a considerable variation in the histologic subtype of epithelial malignancies among carcinoma ex pleomorphic adenomas (CXPA) and virtually any known carcinoma entity can develop.
  • To our knowledge, adenoid cystic carcinoma (AdCC) ex PA is quite rare despite the fact that de novo AdCC is the fourth most common salivary gland malignancy.
  • We describe a new case of AdCC ex PA in the parotid gland of a 62 year-old woman.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19644550.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Carcinoma ex pleomorphic adenoma / High-grade malignancy / Parotid gland
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93. Ma J, Wang J, Zhong M, Wang ZY: [Effects of genistein on the expressions of cell cycle proteins in salivary adenoid cystic carcinoma cell line SACC-83]. Shanghai Kou Qiang Yi Xue; 2006 Feb;15(1):69-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effects of genistein on the expressions of cell cycle proteins in salivary adenoid cystic carcinoma cell line SACC-83].
  • PURPOSE: To investigate the molecular mechanism of cell cycle arrest induced by tyrosine protein kinase inhibitor, genistein, in human salivary adenoid cystic carcinoma cell line SACC-83.
  • Treated with 220 micromol/L of genistein for 3 days, the expression level of CyclinB1, Cdk1, CyclinD1 and Cdk4 proteins was 58%, 64%, 46% and 43% of the control group, respectively (P<0.01).
  • CONCLUSION: The cell cycle G2/M arrest induced by genistein in human salivary adenoid cystic carcinoma cell line SACC-83 may be associated with the downregulations of CyclinB1, Cdk1, CyclinD1 and Cdk4 protein expressions.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Cell Cycle Proteins / drug effects. Genistein / pharmacology. Salivary Gland Neoplasms / metabolism

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  • (PMID = 16525614.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; DH2M523P0H / Genistein; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4
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94. Hu K, Gan YH, Li SL, Gao Y, Wu DC, Wang CY, Yu GY: Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma. Oncol Rep; 2009 Jan;21(1):137-43
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  • [Title] Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma.
  • Lung metastasis is one of the important characteristics of salivary adenoid cystic carcinoma (SACC).
  • Although activation of extracellular signal-regulated kinase 1/2 (ERK1/2) pathway may be associated with cancer progression in some malignant tumors, its roles in lung metastasis of SACC remains unclear.
  • The present findings suggested that the elevated expression of activated ERK1/2 may play a role in lung metastasis of salivary adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lung Neoplasms / secondary. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / metabolism. Salivary Gland Neoplasms / pathology

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  • (PMID = 19082454.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3
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95. Zhang Y, Liu J, Xue F, Li J: p16 tumor suppressor therapy in salivary adenoid cystic carcinoma cell line SACC83. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Jul;100(1):70-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p16 tumor suppressor therapy in salivary adenoid cystic carcinoma cell line SACC83.
  • OBJECTIVE: This study aimed to determine the growth inhibitory effects of transfecting the wild-type p16 gene into human salivary adenoid cystic carcinoma (SACC) cells in vitro.
  • CONCLUSION: The study confirmed the reversal effect of wild-type p16 on malignant phenotype of the salivary adenoid cystic carcinoma and provides valuable data for further clinical trial of gene therapy with p16.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Genes, p16 / physiology. Genetic Therapy. Salivary Gland Neoplasms / therapy

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  • (PMID = 15953919.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Tetrazolium Salts; 0 / Thiazoles; 298-93-1 / thiazolyl blue; 9007-49-2 / DNA
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96. Kasamatsu A, Endo Y, Uzawa K, Nakashima D, Koike H, Hashitani S, Numata T, Urade M, Tanzawa H: Identification of candidate genes associated with salivary adenoid cystic carcinomas using combined comparative genomic hybridization and oligonucleotide microarray analyses. Int J Biochem Cell Biol; 2005 Sep;37(9):1869-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of candidate genes associated with salivary adenoid cystic carcinomas using combined comparative genomic hybridization and oligonucleotide microarray analyses.
  • Adenoid cystic carcinoma (ACC) of the salivary gland often has a variable clinical course with a poor prognosis.
  • To investigate DNA copy number aberrations associated with ACCs, we compared comparative genome hybridization data from ACCs (n = 6) with other types of salivary gland tumors such as adenocarcinomas (n = 3) and pleomorphic adenomas (n = 6).
  • A total of 4431 genes were found differentially expressed by at least two-fold between ACCs and normal salivary glands.
  • The function with the highest P value was a cancer-related function (P = 2.52e-4 to 4.71e-2).
  • These results suggested that the combination of copy number and gene expression profiling provides an improved strategy for gene identification in salivary gland ACCs.
  • [MeSH-major] Adenocarcinoma / genetics. Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / genetics. Chromosome Aberrations. Gene Expression Profiling. Salivary Gland Neoplasms / genetics

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  • (PMID = 15908262.001).
  • [ISSN] 1357-2725
  • [Journal-full-title] The international journal of biochemistry & cell biology
  • [ISO-abbreviation] Int. J. Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / RNA, Neoplasm
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97. Alves SM, Cardoso SV, de Fátima Bernardes V, Machado VC, Mesquita RA, Vieira do Carmo MA, Ferreira Aguiar MC: Metallothionein immunostaining in adenoid cystic carcinomas of the salivary glands. Oral Oncol; 2007 Mar;43(3):252-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metallothionein immunostaining in adenoid cystic carcinomas of the salivary glands.
  • Metallothionein (MT) is a protein that has been studied in several tumors as a prognostic factor and as a potential myoepithelial cell marker in breast cancer.
  • The aims of this study were to assess the immunohistochemical staining of MT in adenoid cystic carcinomas of the salivary glands (ACC), and to analyze possible morphological and quantitative variations among the solid, cribriform, and tubular histological subtypes.
  • Our results suggest that MT may be an important tool for immunolocalization of myoepithelial tumor cells in salivary gland neoplasms.
  • [MeSH-major] Carcinoma, Adenoid Cystic / chemistry. Metallothionein / analysis. Neoplasm Proteins / analysis. Salivary Gland Neoplasms / chemistry
  • [MeSH-minor] Adult. Aged. Cell Transformation, Neoplastic / chemistry. Cell Transformation, Neoplastic / pathology. Female. Humans. Immunohistochemistry / methods. Male. Middle Aged. Salivary Glands / pathology

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  • (PMID = 16857408.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 9038-94-2 / Metallothionein
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98. Seethala RR, Pasha TL, Raghunath PN, Livolsi VA, Zhang PJ: The selective expression of CD43 in adenoid cystic carcinoma. Appl Immunohistochem Mol Morphol; 2008 Mar;16(2):165-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The selective expression of CD43 in adenoid cystic carcinoma.
  • We describe CD43 expression by immunohistochemistry and mRNA in situ hybridization in adenoid cystic carcinomas (ACCs).
  • CD43 immunoreactivity with 2 different antibodies was detected mainly in ACC but also 1 membranous type basal cell adenocarcinoma and 1 colonic adenocarcinoma.
  • Nine of 20 (45%) ACC (8/17 salivary/mucoserous and 1/3 mammary) showed immunoreactivity with clone MT1 whereas 4 (23.5%) salivary ACC also showed immunoreactivity with clone DF-T1.
  • Hence, CD43 seems to be selectively expressed in a subset of ACC and its significance in salivary tumors is discussed.

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  • (PMID = 18227725.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD43; 0 / RNA, Messenger; 0 / UN1 sialoglycoprotein, human
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99. Yan BZ, Wang J, Zhang B, Dong FS, Hou L, Wang X: [Expression of p53 gene with DNA polbeta and CMV promoter in salivary adenoid cystic carcinoma cells]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2007 Feb;25(1):22-5, 28
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of p53 gene with DNA polbeta and CMV promoter in salivary adenoid cystic carcinoma cells].
  • OBJECTIVE: To evaluate the activity of DNA polbeta promoter on p53 gene in salivary adenoid cystic carcinoma (SACC) cells.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Salivary Gland Neoplasms

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  • (PMID = 17375570.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Messenger; 9007-49-2 / DNA; BBX060AN9V / Hydrogen Peroxide
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100. Zhang S, Wang XL, Gan YH, Li SL: Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells. Anticancer Drugs; 2010 Aug;21(7):678-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells.
  • This study aims to explore the proapoptotic effects and underlying mechanisms of statins on human salivary adenoid cystic carcinoma (SACC).
  • A remarkable decrease in phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and increase in phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated kinase were observed.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Adenoid Cystic / enzymology. Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use. JNK Mitogen-Activated Protein Kinases / metabolism. Lovastatin / analogs & derivatives. Salivary Gland Neoplasms / enzymology






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