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6. Jereczek-Fossa BA, Krengli M, Orecchia R: Particle beam radiotherapy for head and neck tumors: radiobiological basis and clinical experience. Head Neck; 2006 Aug;28(8):750-60
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  • It is now well accepted that there are certain indications for using proton therapy for skull base tumors (chordoma and chondrosarcoma), paranasal sinus carcinomas, selected nasopharyngeal tumors, and neutron/ion therapy for salivary gland carcinomas (in particular, adenoid cystic tumors).
  • Its viability in other cases, such as locally advanced squamous cell carcinoma, melanoma, soft tissue sarcoma, and bone sarcoma, is still under investigation.
  • [MeSH-minor] Chordoma / radiotherapy. Humans. Melanoma / radiotherapy. Nose Neoplasms / radiotherapy. Pharyngeal Neoplasms / radiotherapy. Radiobiology. Radiotherapy Dosage. Salivary Gland Neoplasms / radiotherapy. Skin Neoplasms / radiotherapy. Skull Base Neoplasms / radiotherapy

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  • (PMID = 16804876.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 80
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7. Dhanuthai K, Boonadulyarat M, Jaengjongdee T, Jiruedee K: A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais. J Oral Pathol Med; 2009 Jul;38(6):495-500
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  • [Title] A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais.
  • BACKGROUND: There have been several epidemiologic studies on intra-oral salivary gland tumors in several countries, but little is known of these tumors in Thailand.
  • OBJECTIVES: To determine the relative frequency and distribution of various types of intra-oral salivary gland tumors in the Thai population.
  • METHODS: The files of the Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, from 1969 to 2007 were searched for intra-oral salivary gland tumors.
  • RESULTS: Of the 16,358 accessioned cases, 311 cases (1.90%) were diagnosed as intra-oral salivary gland tumors.
  • Pleomorphic adenoma was the most common intra-oral salivary gland tumor.
  • CONCLUSIONS: Pleomorphic adenoma is the most common intra-oral salivary gland tumor and the most common benign intra-oral salivary gland tumor, while mucoepidermoid carcinoma is the most common malignant intra-oral salivary gland tumor.
  • Intra-oral salivary gland tumors in Thailand elicit similar trend as in previous studies, with only minor differences such as the ranking of some tumors, the higher incidence of intra-bony location, and the lower incidence of polymorphous low-grade adenocarcinoma.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. Female. Humans. Incidence. Male. Middle Aged. Palatal Neoplasms / epidemiology. Retrospective Studies. Sex Factors. Thailand / epidemiology. Young Adult

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  • (PMID = 19594840.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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8. Williams MD, Chakravarti N, Kies MS, Maruya S, Myers JN, Haviland JC, Weber RS, Lotan R, El-Naggar AK: Implications of methylation patterns of cancer genes in salivary gland tumors. Clin Cancer Res; 2006 Dec 15;12(24):7353-8
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  • [Title] Implications of methylation patterns of cancer genes in salivary gland tumors.
  • PURPOSE: We investigated the methylation status and protein expression of four tumor suppressor genes to determine their role in salivary gland tumorigenesis.
  • EXPERIMENTAL DESIGN: We performed methylation-specific PCR and protein analyses of 29 normal salivary glands, 23 benign, and 79 malignant salivary gland neoplasms to determine the pattern and potential diagnostic and/or biological role of the RASSF1, RARbeta2, DAPK, and MGMT tumor suppressor gene methylation in these tumors.
  • Methylation occurred in 33 of 79 (41.8%) malignant tumors; 8 (30.8%) adenoid cystic carcinomas, 6 (33.3%) mucoepidermoid carcinomas, 6 (42.9%) acinic cell carcinomas, and 13 (62.0%) salivary duct carcinomas.
  • RASSF1 and RARbeta2 represented 75.8% of methylation events occurring most frequently in salivary duct and acinic cell carcinomas.
  • CONCLUSIONS: (a) Benign and malignant salivary tumors differed in the frequency and pattern of gene methylation;.
  • [MeSH-major] Carcinoma / metabolism. DNA Methylation. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Apoptosis Regulatory Proteins / metabolism. Calcium-Calmodulin-Dependent Protein Kinases / metabolism. Carcinoma, Acinar Cell / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / metabolism. Child. DNA Modification Methylases. DNA Repair Enzymes. Death-Associated Protein Kinases. Female. Gene Expression Regulation, Neoplastic. Genes, Neoplasm. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Receptors, Retinoic Acid / metabolism. Tumor Suppressor Protein p14ARF / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 17189407.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Neoplasm Proteins; 0 / RASSF1 protein, human; 0 / Receptors, Retinoic Acid; 0 / Tumor Suppressor Protein p14ARF; 0 / Tumor Suppressor Proteins; 0 / retinoic acid receptor beta; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 2.7.11.1 / Death-Associated Protein Kinases; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases; EC 6.5.1.- / DNA Repair Enzymes
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9. Zhou CX, Gao Y: Aberrant expression of beta-catenin, Pin1 and cylin D1 in salivary adenoid cystic carcinoma: relation to tumor proliferation and metastasis. Oncol Rep; 2006 Sep;16(3):505-11
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  • [Title] Aberrant expression of beta-catenin, Pin1 and cylin D1 in salivary adenoid cystic carcinoma: relation to tumor proliferation and metastasis.
  • The aims of this study were to investigate the expression levels of beta-catenin, Pin1 and cyclin D1 in salivary adenoid cystic carcinomas (SACC ) and to evaluate its clinical importance, furthermore, to elucidate whether beta-catenin expression was aberrant in SACC and whether Pin1 was involved in aberrant beta-catenin and cyclin D1 expression.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Cyclin D1 / metabolism. Peptidylprolyl Isomerase / metabolism. Salivary Gland Neoplasms / metabolism. beta Catenin / metabolism


10. Moore BA, Burkey BB, Netterville JL, Butcher RB 2nd, Amedee RG: Surgical management of minor salivary gland neoplasms of the palate. Ochsner J; 2008;8(4):172-80
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  • [Title] Surgical management of minor salivary gland neoplasms of the palate.
  • OBJECTIVE: Minor salivary gland tumors are uncommon, accounting for up to 15% of salivary gland neoplasms.
  • We describe our experience with both benign and malignant tumors of the palatal minor salivary glands, focusing on the extent of resection and options for defect reconstruction.
  • RESULTS: From 1994 to 2002, 37 patients with primary neoplasms originating in the palatal minor salivary glands were treated at a single institution.
  • The most common malignant tumor encountered was low grade polymorphous adenocarcinoma, followed by mucoepidermoid carcinoma, and adenoid cystic carcinoma.
  • CONCLUSIONS: Neoplasms of the minor salivary glands in the palate may be excised, with limits dictated by tumor histopathology and perineural invasion.

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  • (PMID = 21603498.001).
  • [ISSN] 1524-5012
  • [Journal-full-title] The Ochsner journal
  • [ISO-abbreviation] Ochsner J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3096363
  • [Keywords] NOTNLM ; Palate / salivary gland neoplasms
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11. Vékony H, Ylstra B, Wilting SM, Meijer GA, van de Wiel MA, Leemans CR, van der Waal I, Bloemena E: DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma. Clin Cancer Res; 2007 Jun 1;13(11):3133-9
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  • [Title] DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma.
  • PURPOSE: Adenoid cystic carcinoma (ACC) is a malignant salivary gland tumor with a high mortality rate due to late, distant metastases.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. DNA, Neoplasm / metabolism. Gene Expression Regulation, Neoplastic. Intercellular Signaling Peptides and Proteins / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 17545515.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Intercellular Signaling Peptides and Proteins; 0 / Platelet-Derived Growth Factor; 62031-54-3 / Fibroblast Growth Factors; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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12. Foschini MP, Gaiba A, Cocchi R, Pennesi MG, Pession A: p63 expression in salivary gland tumors: role of DeltaNp73L in neoplastic transformation. Int J Surg Pathol; 2005 Oct;13(4):329-35
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  • [Title] p63 expression in salivary gland tumors: role of DeltaNp73L in neoplastic transformation.
  • To illustrate the role of p63 and its truncated variants in salivary gland tumors, 23 consecutive tumors and 6 normal salivary glands were studied immunohistochemically with anti-p63 antibody and by reverse transcriptase (RT) and nested polymerase chain reaction (PCR) to detect p63 isoform expression.
  • Normal salivary glands: p63 antibody-stained basal and myoepithelial cells; by RT and nested PCR, the 2 main isoforms were present, whereas DeltaNp73L was absent.
  • Tumors: p63 antibody was positive in the following: Warthin tumor (WT) (3/3), oncocytoma (OC) (1/1), pleomorphic adenoma (PA) (7/7), polymorphous-low-grade adenocarcinoma (PLGA) (3/3), adenoid-cystic carcinoma (ADCC)(3/4), epithelial-myoepithelial-cell carcinoma (EMC) (1/1), and myoepithelial-cell carcinoma (MCC) (1/1).
  • The DeltaNp73L isoform was present in tumoral tissue but absent in normal salivary gland.
  • These data suggest that p63, particularly its splice variant DeltaNp73L, is involved in the neoplastic transformation of salivary glands.
  • [MeSH-major] Cell Transformation, Neoplastic. Phosphoproteins / genetics. Phosphoproteins / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / pathology. Trans-Activators / genetics. Trans-Activators / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenolymphoma / metabolism. Adenolymphoma / pathology. Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Adult. Aged. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cell Proliferation. DNA-Binding Proteins. Exons. Female. Gene Expression Regulation, Neoplastic. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Male. Middle Aged. Myoepithelioma / metabolism. Myoepithelioma / pathology. Polymerase Chain Reaction. Protein Isoforms. Reverse Transcriptase Polymerase Chain Reaction. Salivary Glands / cytology. Salivary Glands / metabolism. Salivary Glands / pathology. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 16273188.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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13. Papadogeorgakis N, Kalfarentzos EF, Vourlakou C, Malta F, Exarhos D: Simultaneous pleomorphic adenoma of the left parotid gland and adenoid cystic carcinoma of the contralateral sublingual salivary gland: a case report. Oral Maxillofac Surg; 2009 Dec;13(4):221-4
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  • [Title] Simultaneous pleomorphic adenoma of the left parotid gland and adenoid cystic carcinoma of the contralateral sublingual salivary gland: a case report.
  • INTRODUCTION: Sublingual salivary gland neoplasms are extremely rare, accounting for only 0.3-1% of all epithelial salivary gland tumors.
  • Most of the sublingual tumors are malignant, adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) being the most common histological types.
  • The coexistence of two salivary gland tumors located in different major salivary glands is uncommon.
  • CASE REPORT: A rare case of two simultaneous tumors of the major salivary glands, one in the sublingual and the other in the contralateral parotid gland in a female patient is reported.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Sublingual Gland Neoplasms / pathology

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  • (PMID = 19690903.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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4. Edwards PC, Wasserman P: Evaluation of cystic salivary gland lesions by fine needle aspiration: an analysis of 21 cases. Acta Cytol; 2005 Sep-Oct;49(5):489-94
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  • [Title] Evaluation of cystic salivary gland lesions by fine needle aspiration: an analysis of 21 cases.
  • OBJECTIVE: To analyze the potential sources of diagnostic errors and overall accuracy rate of the fine needle aspiration biopsy (FNAB) diagnosis of cystic salivary gland neoplasms.
  • STUDY DESIGN: A 10-year (1993-2002) retrospective review of the cytopathology slides from the Division of Cytopathology, Department of Pathology, Long Island Jewish Medical Center, New Hyde Park, New York, identified a total of 97 consecutive salivary gland FNAB cases that microscopically were interpreted as representing cystic lesions.
  • RESULTS: A correct diagnosis was rendered by FNAB in 15 of 21 (72%) cases.
  • CONCLUSION: A systematic approach to the diagnosis of cystic salivary gland lesions by FNAB can result in a correct diagnosis in > 70% of cases.
  • It is important to recognize, however, that occasionally epithelial cells may not be detected on FNAB of cystic salivary gland lesions, as a result of either cellular dilution by cystfluid or inadequate sampling.
  • Regardless, with all FNABs tentatively diagnosed as a mucinous cystic lesion, the referring clinician should be informed that a low grade mucoepidermoid carcinoma cannot be ruled out.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Diagnostic Errors / prevention & control. Epithelial Cells / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Abscess / pathology. Adenolymphoma / pathology. Biopsy, Fine-Needle. Carcinoma, Mucoepidermoid / pathology. Cystadenoma / pathology. Diagnosis, Differential. Extracellular Fluid / metabolism. Histiocytes / pathology. Humans. Lymphocytes / pathology. Observer Variation. Predictive Value of Tests. Reproducibility of Results. Retrospective Studies

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  • [CommentIn] Acta Cytol. 2007 Jul-Aug;51(4):675-6 [17718154.001]
  • (PMID = 16334024.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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15. Ota T, Ota K, Jono H, Fujimori H, Ueda M, Shinriki S, Sueyoshi T, Shinohara M, Ando Y: Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis. Oral Oncol; 2010 Sep;46(9):657-61
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  • [Title] Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis.
  • The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy.
  • We performed immunohistochemistry to examine MK expression in specimens of adenoid cystic carcinoma (ACC), mucoepidermoid carcinoma (MEC), and pleomorphic adenoma (PA).
  • [MeSH-major] Carcinoma, Mucoepidermoid / metabolism. Cytokines / physiology. Neoplasm Proteins / physiology. Neovascularization, Pathologic / pathology. Salivary Gland Neoplasms / metabolism

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20637680.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Neoplasm Proteins; 137497-38-2 / midkine
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16. Bobbio A, Copelli C, Ampollini L, Bianchi B, Carbognani P, Bettati S, Sesenna E, Rusca M: Lung metastasis resection of adenoid cystic carcinoma of salivary glands. Eur J Cardiothorac Surg; 2008 May;33(5):790-3
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  • [Title] Lung metastasis resection of adenoid cystic carcinoma of salivary glands.
  • BACKGROUND: Adenoid cystic carcinoma is a rare tumour originating from the exocrine mucous glands, known for its high propensity for distant metastases.
  • The value of lung metastasis resection from adenoid cystic carcinoma of salivary glands origin is evaluated.
  • METHODS: A retrospective study was conducted on patients undergoing surgery for primary adenoid cystic carcinoma of the salivary glands between 1982 and 2006.
  • RESULTS: Twenty-six men and 24 women with a median age of 57 years (range 33-79) underwent radical surgery for adenoid cystic carcinoma during the study period.
  • CONCLUSIONS: Patients with adenoid cystic carcinoma could be frequently encountered with disease recurrence confined to the lung.
  • [MeSH-major] Lung Neoplasms / secondary. Lung Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / secondary. Carcinoma, Adenoid Cystic / surgery. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Linear Models. Male. Middle Aged. Retrospective Studies. Survival Rate

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  • (PMID = 18343149.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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17. Dahse R, Driemel O, Schwarz S, Dahse J, Kromeyer-Hauschild K, Berndt A, Kosmehl H: Epidermal growth factor receptor kinase domain mutations are rare in salivary gland carcinomas. Br J Cancer; 2009 Feb 24;100(4):623-5
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  • [Title] Epidermal growth factor receptor kinase domain mutations are rare in salivary gland carcinomas.
  • Activating mutations within the epidermal growth factor (EGFR) tyrosine kinase domain identify non-small cell lung cancer patients with improved clinical response to tyrosine kinase inhibitor therapy.
  • Recently, we identified two EGFR mutations in a cohort of 25 salivary gland carcinomas (SGCs) by screening the tumour samples for the both most common hotspot mutations in exons 19 and 21 by allele-specific PCR.
  • No additional mutations other than the two known exon 19 deletions (c.2235_2249del15) in a mucoepidermoid carcinoma and an adenoid cystic carcinoma have been detected.
  • [MeSH-major] Mutation. Receptor, Epidermal Growth Factor / genetics. Salivary Gland Neoplasms / genetics

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  • (PMID = 19174819.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ PMC2653741
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18. Ito FA, Ito K, Vargas PA, de Almeida OP, Lopes MA: Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. Int J Oral Maxillofac Surg; 2005 Jul;34(5):533-6
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  • [Title] Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases.
  • Salivary gland tumors are uncommon and the microscopical features can be complex.
  • In this study, 496 epithelial and mesenchymal tumors of major and minor salivary glands diagnosed at Londrina Cancer Institute during the period from 1972 to 2001 were reviewed.
  • The majority of the cases occurred in the parotid gland (67.7%), followed by the minor salivary glands (22.8%) and submandibular gland (9.5%).
  • Among the minor salivary gland tumors, the palate was the most frequent location (67%).
  • Pleomorphic adenoma was the most frequent tumor representing 54.2% of all cases, followed by mucoepidermoid carcinoma (13.5%), Warthin's tumor (8.5%) and adenoid cystic carcinoma (7.9%).
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Brazil / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. Female. Humans. Male. Middle Aged. Neoplasms, Glandular and Epithelial / epidemiology. Palate / pathology. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Sex Factors. Submandibular Gland Neoplasms / epidemiology

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  • (PMID = 16053874.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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19. Daneshbod Y, Daneshbod K, Khademi B: Diagnostic difficulties in the interpretation of fine needle aspirate samples in salivary lesions: diagnostic pitfalls revisited. Acta Cytol; 2009 Jan-Feb;53(1):53-70
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  • [Title] Diagnostic difficulties in the interpretation of fine needle aspirate samples in salivary lesions: diagnostic pitfalls revisited.
  • OBJECTIVE: To present our experience in diagnostic errors and pitfalls on aspiration cytology of salivary region in a high volume of cases.
  • STUDY DESIGN: In a retrospective review of cytology files of a head and neck referral center from 1990 to 2005, the false positive and false negative interpretations on fine needle aspiration (FNA) of salivary lesions were retrieved.
  • These records and slides were reviewed to identify cytologic characteristics that contributed to false diagnosis.
  • RESULTS: Of a total of 1,040 salivary FNA samples, 376 cases had a final histologic diagnosis with interpretations of benign or malignant.
  • The most common false negative cases were acinic cell carcinoma, epithelial myoepithelial carcinoma, adenoid cystic carcinoma and basal cell adenocarcinoma.
  • Benign cases with false positive diagnosis were Warthin tumor and pleomorphic adenoma.
  • CONCLUSION: Knowledge of cytologic overlaps and pitfalls on salivary gland FNA, as well as clinical and radiologic features, may help clinicians arrive at the appropriate diagnosis and reduce false interpretations.
  • [MeSH-major] Salivary Gland Neoplasms / diagnosis. Salivary Glands / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Child. Child, Preschool. Diagnosis, Differential. False Negative Reactions. False Positive Reactions. Female. Humans. Infant. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity. Young Adult

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  • (PMID = 19248555.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Masuya D, Haba R, Huang CL, Yokomise H: Myoepithelial carcinoma of the lung. Eur J Cardiothorac Surg; 2005 Nov;28(5):775-7
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  • [Title] Myoepithelial carcinoma of the lung.
  • Primary lung carcinomas showing features of salivary gland-type neoplasms are rare.
  • Many are mucoepidermoid carcinomas and adenoid cystic carcinomas.
  • Myoepithelial carcinoma of the lung is extremely rare, and in the WHO classification is classified as 'Others' among carcinomas of the salivary gland.
  • Here we report a resected case of myoepithelial carcinoma of the lung, including details of clinical examination, with a review of previously documented cases.

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  • (PMID = 16188445.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 5
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21. Lu YG, Ding LC, Zhou HY, Deng SS, Wang QM, Xiong RH, Yang HJ: [The expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in transplanted tumor of salivary adenoid cystic carcinoma cell lines]. Shanghai Kou Qiang Yi Xue; 2006 Oct;15(5):526-30
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  • [Title] [The expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in transplanted tumor of salivary adenoid cystic carcinoma cell lines].
  • CONCLUSION: The differential expression pattern of MMP-2, MMP-7, MMP-9, and TIMP-1 in 2 tumor models may result in different metastasis potential; The 2 tumor models provide good study model for investigation of the metastatic mechanism of salivary adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Cell Line, Tumor. Disease Models, Animal. Matrix Metalloproteinases / biosynthesis. Neoplasm Transplantation. Salivary Gland Neoplasms. Tissue Inhibitor of Metalloproteinases / biosynthesis

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  • (PMID = 17348230.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Tissue Inhibitor of Metalloproteinase-1; 0 / Tissue Inhibitor of Metalloproteinases; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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22. Atarbashi Moghadam S, Atarbashi Moghadam F, Dadfar M: Epithelial salivary gland tumors in ahvaz, southwest of iran. J Dent Res Dent Clin Dent Prospects; 2010;4(4):120-3
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  • [Title] Epithelial salivary gland tumors in ahvaz, southwest of iran.
  • BACKGROUND AND AIMS: Salivary gland tumors are rare and specific lesions.
  • There are differences in the incidence and frequency of salivary tumors in both minor and major salivary glands in different countries.
  • This study was carried out to determine the prevalence of major and minor salivary gland tumors in Ahvaz in the south of Iran.
  • The incidence of malignant salivary gland tumors increased with age and male predominance was found in malignant tumors.
  • The majority of the tumors occurred in parotid gland.
  • Mucoepidermoid carcinoma and adenoid cystic carcinoma were the most common malignant tumors.
  • CONCLUSION: It was shown that the peak incidence age of all salivary gland tumors was the third to fifth decades, and malignant tumors mostly occurred in the sixth to eighth decades.
  • The most common malignant tumors were mucoepidermoid carcinoma and adenoid cystic carcinoma.

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  • (PMID = 23346338.001).
  • [ISSN] 2008-210X
  • [Journal-full-title] Journal of dental research, dental clinics, dental prospects
  • [ISO-abbreviation] J Dent Res Dent Clin Dent Prospects
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3429964
  • [Keywords] NOTNLM ; Epithelial salivary gland tumors / major salivary gland tumors / minor salivary gland tumors / salivary gland
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23. Al-Sukhun J, Lindqvist C, Hietanen J, Leivo I, Penttilä H: Central adenoid cystic carcinoma of the mandible: case report and literature review of 16 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Mar;101(3):304-8
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  • [Title] Central adenoid cystic carcinoma of the mandible: case report and literature review of 16 cases.
  • Central intraosseous adenoid cystic carcinoma (ACC) of the mandible, formerly known as cylindroma, is a rare neoplasm with only 16 cases reported in the literature.
  • We describe the diagnosis, etiology, and treatment of a central ACC located in the mandibular premolar region.
  • This case illustrates 2 key facts regarding the diagnosis and etiology of ACC.
  • First, central salivary gland tumors should be considered in the differential diagnosis of cystic lytic lesions in the mandible.
  • Second, even though the origin of this type of tumor is still unknown, the presence of ectopic tissue anterior to the submandibular gland in the submandibular area indicates that this tumor might be made up of ectopic embryogenic inclusions.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Mandibular Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Choristoma. Diagnosis, Differential. Female. Humans. Mandibular Diseases / diagnosis. Submandibular Gland. Submandibular Gland Neoplasms / diagnosis

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  • (PMID = 16504862.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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24. Beltran D, Faquin WC, Gallagher G, August M: Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma. J Oral Maxillofac Surg; 2006 Mar;64(3):415-23
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  • [Title] Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma.
  • PURPOSE: Polymorphous low-grade adenocarcinoma (PLGA) is a salivary gland malignancy characterized by indolent growth and a low rate of metastasis.
  • PLGA shares histological features with adenoid cystic carcinoma (ACC), including infiltrating solid and cribriform patterns, presence of cystic spaces, and neurotropism.
  • This study examines the potential use of c-kit, Ki-67, smooth muscle actin (SMA), and muscle-specific actin (MSA) as ancillary markers for distinguishing PLGA from ACC.
  • RESULTS: PLGA showed a significantly weaker immunohistochemical expression of c-kit compared with ACC (P = < .001).
  • CONCLUSIONS: Statistically significant immunohistochemical staining patterns using c-kit and SMA in this study support their potential use as markers to differentiate PLGA from ACC in cases where the diagnosis can be challenging.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. Salivary Gland Neoplasms / chemistry. Salivary Gland Neoplasms / classification
  • [MeSH-minor] Actins / analysis. Adult. Aged. Aged, 80 and over. Cytoskeletal Proteins / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Muscle Proteins / analysis. Neoplasm Proteins / analysis. Proto-Oncogene Proteins c-kit / analysis. Statistics, Nonparametric

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  • (PMID = 16487803.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Ki-67 Antigen; 0 / Muscle Proteins; 0 / Neoplasm Proteins; 0 / Smooth muscle protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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25. Chu WF, Wu DM, Liu W, Wu LJ, Li DZ, Xu DY, Wang XF: Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma. Oral Oncol; 2009 Nov;45(11):998-1004
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  • [Title] Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma.
  • New chemotherapeutic strategy should be investigated to enhance clinical management in salivary gland adenoid cystic carcinoma (ACC).
  • Recently, sulforaphane (SFN), as a natural compound from cruciferous vegetables exhibits a potent anti-cancer activity in various tumor cells, but remains uncertain in ACC cells.
  • Cell survives, apoptosis, cell cycle progression and molecular targets were identified by multiple detecting techniques, including trypan blue dye exclusion assay, electron microscopy, AO/EB staining, flow cytometry and immunoblotting in human lung high metastasis cell line of salivary gland adenoid cystic carcinoma (ACC-M).
  • [MeSH-major] Anticarcinogenic Agents / pharmacology. Carcinoma, Adenoid Cystic / drug therapy. Lung Neoplasms / drug therapy. Salivary Gland Neoplasms / drug therapy. Thiocyanates / pharmacology


26. Yih WY, Kratochvil FJ, Stewart JC: Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg; 2005 Jun;63(6):805-10
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  • [Title] Intraoral minor salivary gland neoplasms: review of 213 cases.
  • PURPOSE: Minor salivary gland tumors (MSGTs) constitute a heterogeneous group of neoplasms with great histomorphologic variation.
  • This study reviews a large series of benign and malignant salivary gland tumors of the oral region and determines the incidence and the correlation of the histopathologic features with the clinical characteristics.
  • Of the 94 malignant MSGTs, mucoepidermoid carcinoma (MEC) (45 of 94), adenoid cystic carcinoma (22 of 94), and polymorphous low-grade adenocarcinoma (18 of 94) were the most common.
  • The palate is the most common site for minor gland neoplasms.
  • Benign labial salivary gland neoplasms are more common in the upper lip, and malignant labial tumors are more common in the lower lip.
  • [MeSH-major] Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 15944978.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Khafif A, Anavi Y, Haviv J, Fienmesser R, Calderon S, Marshak G: Adenoid cystic carcinoma of the salivary glands: a 20-year review with long-term follow-up. Ear Nose Throat J; 2005 Oct;84(10):662, 664-7
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  • [Title] Adenoid cystic carcinoma of the salivary glands: a 20-year review with long-term follow-up.
  • The behavior of adenoid cystic carcinoma (ACC) of the salivary glands has been shown to be unpredictable in terms of local and distant spread and mortality.
  • We retrospectively studied 35 operations in 34 patients who had had a pathologic diagnosis of ACC of the salivary glands and who had been treated over a 20-year period and followed for a minimum of 10 years.
  • The site of origin appeared to be an important factor in survival rates; survival among patients with tumors that had originated in the parotid gland was fairly good, while survival among those with tumors that originated in the minor salivary glands was significantly worse.
  • We recommend radical surgery with complete resection for all patients with ACC of the salivary glands and a careful assessment of the neck in patients with minor salivary gland tumors.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 16382750.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Ma J, Zhong M, Wang ZY: [Anti-proliferation effect of genistein on salivary adenoid cystic carcinoma cell line SACC-83 in vitro]. Shanghai Kou Qiang Yi Xue; 2005 Feb;14(1):55-8
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  • [Title] [Anti-proliferation effect of genistein on salivary adenoid cystic carcinoma cell line SACC-83 in vitro].
  • PURPOSE: To investigate the anti-proliferation effect of tyrosine protein kinase inhibitor, genistein (4'-5,7-trihydroxyisoflavone), on human salivary adenoid cystic carcinoma cell line SACC-83 in vitro, and its effect on cell cycle.
  • CONCLUSION: Genistein inhibits growth of human salivary adenoid cystic carcinoma cell line SACC-83, arrests cell cycle in G2/M phase, and induces cell apoptosis; these suggest that tyrosine protein kinase has important effect on the neoplasia and development of salivary adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Cell Proliferation / drug effects. Genistein / pharmacology. Salivary Gland Neoplasms / pathology


29. Tincani AJ, Del Negro A, Araújo PP, Akashi HK, Martins AS, Altemani AM, Barreto G: Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series. Sao Paulo Med J; 2006 Jan 5;124(1):26-30
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  • [Title] Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series.
  • CONTEXT AND OBJECTIVE: Salivary gland tumor management requires long-term follow-up because of tumor indolence and possible late recurrence and distant metastasis.
  • Adenoid cystic carcinoma (ACC) accounts for 10-15% of such tumors.
  • DESIGN AND SETTING: Retrospective study at Head and Neck Service, Universidade Estadual de Campinas.
  • Major salivary gland tumor extent was routinely assessed by preoperative ultrasonography.
  • Diagnosis, surgery type, margin type (negative/positive), postoperative radiotherapy and recurrence (presence/absence) were evaluated.
  • RESULTS: There were eleven major salivary gland tumors (52.3%), seven submandibular and four parotid.
  • Ten patients (47.7%) had minor salivary gland ACC (all in palate), while the submandibular was the most frequently affected major one.
  • CONCLUSION: Adenoid cystic carcinoma has locally aggressive behavior.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 16612459.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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30. Aubry MC, Heinrich MC, Molina J, Lewis JE, Yang P, Cassivi SD, Corless CL: Primary adenoid cystic carcinoma of the lung: absence of KIT mutations. Cancer; 2007 Dec 1;110(11):2507-10
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  • [Title] Primary adenoid cystic carcinoma of the lung: absence of KIT mutations.
  • BACKGROUND: Primary pulmonary adenoid cystic carcinomas (ACCs) are rare lung neoplasms that are challenging to completely resect and can exhibit poor survival.
  • METHODS: Primary salivary gland-type tumors of the lung diagnosed between 1972 and 2002 at the Mayo Clinic were identified and the subset of primary pulmonary ACCs were reviewed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Lung Neoplasms / metabolism. Mutation. Proto-Oncogene Proteins c-kit / genetics. Proto-Oncogene Proteins c-kit / metabolism

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  • (PMID = 17932891.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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31. Sun G, Yang X, Tang E, Wen J, Lu M, Hu Q: The treatment of sublingual gland tumours. Int J Oral Maxillofac Surg; 2010 Sep;39(9):863-8
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  • [Title] The treatment of sublingual gland tumours.
  • This study assessed the clinical and histological features and therapeutic efficacy of 25 cases of sublingual gland tumours from 1998 to 2008.
  • 21 cases were malignant sublingual gland tumours (84%) and of these, 18 were adenoid cystic carcinoma (86%).
  • Adenoid cystic carcinoma was mainly of the histological type, and the other histological classifications included mucoepidermoid carcinoma, pleomorphic adenoma, myoepithelioma, oncocytoma and polymorphous low-grade adenocarcinoma.
  • Sublingual gland tumours are rare and most are malignant.
  • For malignant sublingual gland tumours, early diagnosis and aggressive surgical treatment, especially for tumours with nerve involvement, is the key to improving prognosis.
  • For benign sublingual gland tumours, the resection of tumour and sublingual gland is the preferred treatment.
  • [MeSH-major] Carcinoma / therapy. Salivary Gland Diseases / pathology. Sublingual Gland / pathology. Sublingual Gland Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / therapy. Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / therapy. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / therapy. Adult. Aged. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / therapy. Carcinoma, Mucoepidermoid / pathology. Carcinoma, Mucoepidermoid / therapy. Female. Humans. Male. Middle Aged. Myoepithelioma / pathology. Myoepithelioma / therapy. Reconstructive Surgical Procedures / methods

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  • [Copyright] Copyright © 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20605409.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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32. Bernardini FP, Devoto MH, Croxatto JO: Epithelial tumors of the lacrimal gland: an update. Curr Opin Ophthalmol; 2008 Sep;19(5):409-13
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  • [Title] Epithelial tumors of the lacrimal gland: an update.
  • PURPOSE OF REVIEW: The goal of this article is to offer an update on the treatment and prognosis of the most common epithelial tumors of the lacrimal gland, report on new pathological entities and offer a review of the classification of lacrimal gland tumors.
  • RECENT FINDINGS: Improvements have been made in the understanding of lacrimal gland lesions with the knowledge that lacrimal gland tumors compare to the more common counterparts of the major salivary glands.
  • Therefore, the WHO's classification of salivary gland tumors has been adapted to the lacrimal gland pathology.
  • Until recently, primary adenocarcinomas of the lacrimal gland were not further subclassified, but they can now be divided into low-grade and high-grade malignancies.
  • The adjunctive use of intra-arterial cytoreductive chemotherapy for the management of adenoid cystic carcinoma is one of the most important advancements on the management of these aggressive tumors.
  • Another important step forward has been taken on carcinoma ex pleomorphic adenoma of the lacrimal gland, which is subclassified into noninvasive carcinoma, with an excellent prognosis after complete excision and invasive carcinoma for which the prognosis is still guarded despite adjunctive radiotherapy.
  • SUMMARY: This article offers an update on diagnosis, classification and treatment of common and rare epithelial lacrimal gland tumors.

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  • (PMID = 18772674.001).
  • [ISSN] 1531-7021
  • [Journal-full-title] Current opinion in ophthalmology
  • [ISO-abbreviation] Curr Opin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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33. He H, Tang X, Li L, Li L, Hua C, He D: [Effect of mechanical stimulation on the invasion in salivary adenoid cystic carcinoma]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2007 Oct;24(5):1065-8, 1088
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  • [Title] [Effect of mechanical stimulation on the invasion in salivary adenoid cystic carcinoma].
  • This study was aimed to assess the effects of cyclic biaxial mechanical stimulation on the invasion capacity in vitro and on the expression of MMP-9 in the salivary adenoid cystic carcinoma (SACC) high metastatic cell lines ACC-M, and in the SACC low metastatic cell lines ACC-2.
  • It can promote metastasis of the cancer.
  • Moreover, some protein other than MMP-9 may play an important role in the metastasis of the cancer.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Matrix Metalloproteinase 9 / metabolism. Salivary Gland Neoplasms / pathology. Stress, Mechanical

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  • (PMID = 18027698.001).
  • [ISSN] 1001-5515
  • [Journal-full-title] Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
  • [ISO-abbreviation] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.4.24.35 / Matrix Metalloproteinase 9
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34. Ozkara SK, Turan G: Fine needle aspiration cytopathology of primary solid adenoid cystic carcinoma of the lung: a case report. Acta Cytol; 2009 Nov-Dec;53(6):707-10
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  • [Title] Fine needle aspiration cytopathology of primary solid adenoid cystic carcinoma of the lung: a case report.
  • BACKGROUND: Adenoid cystic carcinoma (ACC) is a rare, distinctive salivary gland malignant neoplasm arising infrequently as a primary tumor in the lung.
  • CONCLUSION: A preoperative cytopathologic diagnosis of poorly differentiated primary pulmonary ACC can enhance surgical planning and success of tumor resection.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Lung / pathology. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology

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  • (PMID = 20014565.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Qing J, Zhang Q, Wei MW, Guo ZM: [Prognostic analysis of adenoid cystic carcinoma of major salivary glands of 64 cases]. Ai Zheng; 2006 Sep;25(9):1138-43
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  • [Title] [Prognostic analysis of adenoid cystic carcinoma of major salivary glands of 64 cases].
  • BACKGROUND & OBJECTIVE: Adenoid cystic carcinoma of salivary glands is a kind of highly malignant tumor, and researches on the tumors originated from major salivary glands are rare.
  • This study was to investigate prognostic factors of adenoid cystic carcinoma of major salivary glands.
  • METHODS: Clinical records of 64 patients with adenoid cystic carcinoma of major salivary glands followed up for more than 7 years were reviewed.
  • CONCLUSION: Presence or absence of nerve invasion, histological subtype, clinical stage, and positive or negative surgical margin are the independent factors affecting the prognosis of patients with adenoid cystic carcinoma of salivary glands.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Neoplasm Staging. Parotid Neoplasms / mortality. Parotid Neoplasms / pathology. Parotid Neoplasms / therapy. Prognosis. Radiotherapy, Adjuvant. Submandibular Gland Neoplasms / mortality. Submandibular Gland Neoplasms / pathology. Submandibular Gland Neoplasms / therapy. Survival Rate


36. Yu T, Gao QH, Wang XY, Wen YM, Wang CM, Zhang Y: [A retrospective clinicopathologic study of 30 cases of sublingual gland malignant tumors]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2007 Feb;25(1):64-6
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  • [Title] [A retrospective clinicopathologic study of 30 cases of sublingual gland malignant tumors].
  • OBJECTIVE: To assess the clinical and histological features and therapeutic efficacy of 30 cases of malignant sublingual salivary gland tumors.
  • METHODS: The clinicopathologic data of 30 patients with malignant sublingual salivary gland tumor were obtained from West China Hospital of Stomatology, Sichuan University from 1955 to 2005.
  • Seventeen cases were adenoid cystic carcinoma, accounting for 56.7%.
  • CONCLUSION: Sublingual gland malignant tumors are rare and most of them are adenoid cystic carcinoma.
  • [MeSH-major] Salivary Gland Neoplasms. Sublingual Gland
  • [MeSH-minor] Adult. Aged. Carcinoma, Adenoid Cystic. China. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17375581.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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37. Shi H, Wang J, Wang X, Gu HT, Hou YL, Yu LJ: [Construction of eukaryotic expression vector of short hairpin RNA targeting human xylosyltransferase-I gene]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2008 Apr;26(2):206-10
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  • At last the constructed XT-I expression vectors were transfected into salivary adenoid cystic carcinoma cell line (ACC-M) by Lipofectomine 2000.
  • CONCLUSION: The XT-I shRNA expression vectors were constructed successfully which lays the foundation for RNAi study on the biosynthesis of PG in salivary gland tumors.
  • [MeSH-minor] Carcinoma, Adenoid Cystic. Cell Line. Genetic Vectors. Green Fluorescent Proteins. Humans. Pentosyltransferases. Plasmids. RNA, Messenger. Salivary Gland Neoplasms. Transfection

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  • (PMID = 18605467.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Small Interfering; 147336-22-9 / Green Fluorescent Proteins; EC 2.4.2.- / Pentosyltransferases; EC 2.4.2.26 / UDP xylose-protein xylosyltransferase
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38. Liu P, Liu S, Qi H, Li Y, He H, Wei F: Effects of silencing Id-1 in cell culture of human adenoid cystic carcinoma. Oral Oncol; 2009 Sep;45(9):783-8
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  • [Title] Effects of silencing Id-1 in cell culture of human adenoid cystic carcinoma.
  • Adenoid cystic carcinoma (ACC) is a slow growing but highly invasive cancer with a high recurrence rate.
  • This study aimed to identify the potential role of inhibiting DNA binding-1 (Id-1) in human salivary adenoid cystic carcinoma (SACC) progression.
  • First, we compared the Id-1 protein expression in a human salivary adenoid cystic carcinoma cell line (ACCM) against three other cell lines and found that Id-1 protein expression in ACCM to be significantly higher.
  • Consequently, our data suggest that Id-1 is a potential target in the treatment of human salivary adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Cytoskeletal Proteins / antagonists & inhibitors. Neoplasm Proteins / antagonists & inhibitors. Salivary Gland Neoplasms / metabolism

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  • (PMID = 19213597.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Autoantigens; 0 / Cytoskeletal Proteins; 0 / LMOD1 protein, human; 0 / Neoplasm Proteins; 0 / RNA, Messenger
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39. Sygut D, Bień S, Ziółkowska M, Sporny S: Immunohistochemical expression of androgen receptor in salivary gland cancers. Pol J Pathol; 2008;59(4):205-10
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  • [Title] Immunohistochemical expression of androgen receptor in salivary gland cancers.
  • Accidental discovery of androgen receptor (AR) expression in high-grade salivary gland cancer led to evaluation of that finding.
  • In this study we evaluated the immunohistochemical expression of AR in a series of 37 formalin-fixed, paraffin-embedded malignant salivary gland tumors using two commercially available antibodies.
  • Nuclear immunoreactivity for AR was demonstrated in 3 of 4 salivary duct carcinomas, 2 of 7 adenocarcinomas NOS and 1 of 2 carcinoma ex pleomorphic adenoma for both antibodies.
  • There was no immunoreactivity seen in 13 adenoid cystic carcinomas, 7 mucoepidermoid carcinomas and 4 acinic cell carcinomas.
  • The expression of AR in high-grade salivary gland cancers suggests a possible role for AR in the clinical management of these neoplasms.
  • [MeSH-major] Carcinoma / metabolism. Receptors, Androgen / biosynthesis. Salivary Gland Neoplasms / metabolism

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  • (PMID = 19391487.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Receptors, Androgen
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40. Seethala RR: An update on grading of salivary gland carcinomas. Head Neck Pathol; 2009 Mar;3(1):69-77
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  • [Title] An update on grading of salivary gland carcinomas.
  • Histologic grade is a significant predictor of outcome in salivary gland carcinomas.
  • As our knowledge base has evolved, it is clear that carcinoma ex pleomorphic adenoma is not automatically a high grade tumor as is traditionally suggested.
  • These tumors should be further qualified as to type/grade of carcinoma and extent, since intracapsular and minimally invasive carcinomas ex pleomorphic adenoma behave favorably.
  • The two carcinoma types for which grading schemes are common include adenoid cystic carcinoma and mucoepidermoid carcinoma.
  • Adenoid cystic carcinomas are graded based solely on pattern with solid components portending a worse prognosis.
  • Occasionally, adenoid cystic carcinomas may undergo transformation to pleomorphic high grade carcinomas.
  • Mucoepidermoid carcinomas are graded in a three tier fashion based on a constellation of features including cystic component, border, mitoses, anaplasia, and perineural invasion among others.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology

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  • [Cites] Am J Surg Pathol. 2007 Nov;31(11):1683-94 [18059225.001]
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  • (PMID = 20596994.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2807532
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Carcinoma ex pleomorphic adenoma / Grading / High grade transformation / Mucoepidermoid carcinoma / Salivary carcinoma
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41. He W, Cao XP, Li LJ: [Expression and significance of cyclin D1 in human adenoid cystic carcinoma]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2005 Jun;23(3):191-3
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  • [Title] [Expression and significance of cyclin D1 in human adenoid cystic carcinoma].
  • OBJECTIVE: To observe the expression of cyclin D1 in human adnoid cystic carcinoma and its correlation with clinical characters.
  • METHODS: The expression of cycline D1 was evaluated with immunohistochemical method in forty-one cases of human adnoid cystic carcinoma, 15 cases of PA and 12 cases of normal salivary gland tissue.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Cyclin D1
  • [MeSH-minor] Carcinoma. Female. Humans. Middle Aged. Salivary Gland Neoplasms

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  • (PMID = 16078452.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 136601-57-5 / Cyclin D1
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42. Soon SR, Yong WS, Ho GH, Wong CY, Ho BC, Tan PH: Adenoid cystic breast carcinoma: a salivary gland-type tumour with excellent prognosis and implications for management. Pathology; 2008 Jun;40(4):413-5
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  • [Title] Adenoid cystic breast carcinoma: a salivary gland-type tumour with excellent prognosis and implications for management.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology

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  • (PMID = 18446636.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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43. Emanuel P, Wang B, Wu M, Burstein DE: p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Mod Pathol; 2005 May;18(5):645-50
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  • [Title] p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma.
  • Morphologic distinction of high-grade adenoid cystic carcinoma from basaloid squamous cell carcinoma can be difficult.
  • Archival, routinely processed slides were subjected to citrate-based antigen retrieval, exposure to anti-p63 monoclonal 4A4, and developed with a streptavidin-biotin kit and diaminobenzidine as chromogen. p63 was detected in 100% of the adenoid cystic carcinomas (n=14) and 100% of basaloid squamous cell carcinomas (n=16).
  • In contrast, adenoid cystic carcinoma displayed a consistently compartmentalized pattern within tumor nests.
  • (1) selective staining of a single peripheral layer of p63-positive cells surrounding centrally located tumor cells that were p63-negative and (2) tumor nests consisting of multiple contiguous glandular/cribriform-like units of p63-positive cells surrounding or interspersed with p63-negative cells. p63 immunostaining constitutes a specific and accurate means of distinguishing adenoid cystic carcinoma from basaloid squamous cell carcinoma. p63 positivity in adenoid cystic carcinoma appears to be homologous to that seen in the basal and/or myoepithelial compartments of salivary gland and other epithelia, and may signify a stem-cell-like role for these peripheral cells.
  • Diffuse p63 positivity in basaloid squamous cell carcinoma suggests dysregulation of p63-positive stem cells in poorly differentiated squamous carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Phosphoproteins / analysis. Trans-Activators / analysis
  • [MeSH-minor] DNA-Binding Proteins. Diagnosis, Differential. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 15529180.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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44. Ettl T, Schwarz S, Kleinsasser N, Hartmann A, Reichert TE, Driemel O: Overexpression of EGFR and absence of C-KIT expression correlate with poor prognosis in salivary gland carcinomas. Histopathology; 2008 Nov;53(5):567-77
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  • [Title] Overexpression of EGFR and absence of C-KIT expression correlate with poor prognosis in salivary gland carcinomas.
  • AIMS: To evaluate the prognostic impact of expression of receptor tyrosine kinases epidermal growth factor receptor (EGFR), HER2, and C-KIT in relation to established clinicopathological parameters in salivary gland carcinomas.
  • METHODS AND RESULTS: Immunohistochemistry for EGFR, HER2, C-KIT and the proliferation marker Ki67 was performed in 101 cases of salivary gland carcinoma and related to long-term clinical follow-up.
  • Immunopositivity of C-KIT was common in adenoid cystic carcinoma (92%).
  • Lack of C-KIT expression occurred in salivary duct carcinoma (P < 0.001) and was associated with high-grade tumours (P = 0.002), positive lymph nodes (P = 0.002) and high expression of Ki67 (P = 0.001).
  • HER2 was typically expressed in salivary duct carcinomas (83%), but was not associated with any other parameter.
  • On univariate survival analysis, overexpression of EGFR (P = 0.011) and lack of C-KIT (P = 0.014) were associated with worse prognosis, whereas HER2 was of no prognostic significance.
  • [MeSH-major] Carcinoma / mortality. Carcinoma / pathology. Proto-Oncogene Proteins c-kit / metabolism. Receptor, Epidermal Growth Factor / metabolism. Salivary Gland Neoplasms / mortality. Salivary Gland Neoplasms / pathology


45. Copelli C, Bianchi B, Ferrari S, Ferri A, Sesenna E: Malignant tumors of intraoral minor salivary glands. Oral Oncol; 2008 Jul;44(7):658-63
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  • [Title] Malignant tumors of intraoral minor salivary glands.
  • Between 1995 and 2004, 43 patients with intraoral minor salivary gland carcinomas were diagnosed and treated at the Department of Maxillofacial Surgery, University of Parma, Italy.
  • Adenoid cystic carcinoma was the most common histological type (60.6%), followed by mucoepidermoid carcinoma (27.9%).
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / surgery. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Italy. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection / methods. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / prevention & control. Neoplasm Staging. Radiotherapy, Adjuvant. Salivary Glands, Minor. Survival Analysis. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 17996484.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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46. Vargas PA, Speight PM, Bingle CD, Barrett AW, Bingle L: Expression of PLUNC family members in benign and malignant salivary gland tumours. Oral Dis; 2008 Oct;14(7):613-9
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  • [Title] Expression of PLUNC family members in benign and malignant salivary gland tumours.
  • OBJECTIVES: The aim of this study was to determine the expression of PLUNC proteins in benign and malignant salivary gland tumours and thus their potential use as diagnostic and / or prognostic tools.
  • MATERIALS AND METHODS: A tissue microarray was assembled from 64 salivary gland tumours including adenoid cystic carcinoma, carcinoma ex-pleomorphic adenoma, mucoepidermoid carcinoma, polymorphous low-grade adenocarcinoma, pleomorphic adenoma, acinic cell carcinoma, myoepithelial carcinoma and papillary cystadenocarcinoma.
  • CONCLUSIONS: Intense expression of two PLUNC proteins in mucous cells and mucin plugs of mucoepidermoid carcinoma and papillary cystadenocarcinoma indicate that they could be used as additional diagnostic tools in some equivocal cases, but further studies are needed to understand the biological processes involved in PLUNC expression.
  • [MeSH-major] Biomarkers, Tumor. Carcinoma, Mucoepidermoid / metabolism. Cystadenocarcinoma, Papillary / metabolism. Glycoproteins / biosynthesis. Phosphoproteins / biosynthesis. Salivary Gland Neoplasms / metabolism

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  • (PMID = 18221458.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 076491; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / BPIFA1 protein, human; 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Phosphoproteins
  • [Other-IDs] NLM/ PMC2853704; NLM/ UKMS29166
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47. Monteiro LS, Palmeira C, Bento MJ, Lopes C: DNA content in malignant salivary gland tumours. Oral Dis; 2009 May;15(4):295-301
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] DNA content in malignant salivary gland tumours.
  • OBJECTIVE: Our aim was to evaluate the DNA content in malignant salivary gland tumours using image cytometry and its possible relationships with clinical and morphologic findings, disease course and prognosis.
  • PATIENTS AND METHODS: The study sample comprised 31 patients diagnosed and treated for primary malignant salivary gland tumours.
  • CONCLUSION: Abnormal DNA content is a common finding in salivary gland cancers.
  • [MeSH-major] Carcinoma / genetics. DNA, Neoplasm / analysis. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Aneuploidy. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Diploidy. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Humans. Image Cytometry. Lymphatic Metastasis / genetics. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Parotid Neoplasms / genetics. Parotid Neoplasms / pathology. Polyploidy. Prognosis. Retrospective Studies. Salivary Glands, Minor / pathology. Survival Rate. Young Adult

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  • (PMID = 19320959.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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48. Perez DE, Pires FR, Alves Fde A, Almeida OP, Kowalski LP: Sublingual salivary gland tumors: clinicopathologic study of six cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Oct;100(4):449-53
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  • [Title] Sublingual salivary gland tumors: clinicopathologic study of six cases.
  • OBJECTIVE: The aim of this study was to assess the clinical and histologic features of 6 cases of sublingual salivary gland tumors treated in a single institution.
  • RESULTS: Four cases were adenoid cystic carcinoma (ACC) and 2 were mucoepidermoid carcinoma (MEC).
  • CONCLUSIONS: Sublingual salivary gland tumors are very rare and most are malignant; in our series, 3 cases of ACC had poor prognosis but the patients with MEC were considered cured of the disease.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Sublingual Gland Neoplasms / pathology

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  • (PMID = 16200677.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Ding CS, Yap WM, Teo CH, Giron D, Chuah KL: Tracheal carcinoma ex pleomorphic adenoma: a rare tumour with potential problems in diagnosis. Histopathology; 2007 Dec;51(6):868-71
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  • [Title] Tracheal carcinoma ex pleomorphic adenoma: a rare tumour with potential problems in diagnosis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Mixed Tumor, Malignant / pathology. Salivary Gland Neoplasms / pathology. Tracheal Neoplasms / pathology
  • [MeSH-minor] Aged. Asian Continental Ancestry Group. Carcinoma, Adenoid Cystic / pathology. Diagnosis, Differential. Humans. Male. Pulmonary Disease, Chronic Obstructive / pathology. Smoking

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  • (PMID = 17916072.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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50. Laurie SA, Licitra L: Systemic therapy in the palliative management of advanced salivary gland cancers. J Clin Oncol; 2006 Jun 10;24(17):2673-8
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  • [Title] Systemic therapy in the palliative management of advanced salivary gland cancers.
  • Cancers of the salivary glands are unusual lesions that vary widely in their histologic appearance and molecular characteristics.
  • The majority of patients for whom systemic therapy is considered will have either adenoid cystic carcinoma, mucoepidermoid carcinoma, or high-grade adenocarcinoma.
  • This article will review the available literature regarding the use of palliative chemotherapy for patients with advanced salivary gland cancer of these histologies, with an emphasis on the potential role of targeted agents.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Agents / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Mucoepidermoid / drug therapy. Neoplasm Recurrence, Local / drug therapy. Palliative Care. Salivary Ducts. Salivary Gland Neoplasms / drug therapy

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  • (PMID = 16763282.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Boronic Acids; 0 / Pyrazines; 0 / Quinazolines; 0 / Receptors, Androgen; 0VUA21238F / lapatinib; 0W860991D6 / Deoxycytidine; 69G8BD63PP / Bortezomib; B76N6SBZ8R / gemcitabine; EC 2.7.10.1 / Receptor, ErbB-2; P188ANX8CK / Trastuzumab
  • [Number-of-references] 87
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51. Chen AM, Granchi PJ, Garcia J, Bucci MK, Fu KK, Eisele DW: Local-regional recurrence after surgery without postoperative irradiation for carcinomas of the major salivary glands: implications for adjuvant therapy. Int J Radiat Oncol Biol Phys; 2007 Mar 15;67(4):982-7
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  • [Title] Local-regional recurrence after surgery without postoperative irradiation for carcinomas of the major salivary glands: implications for adjuvant therapy.
  • PURPOSE: To determine factors predictive of local-regional recurrence (LRR) after surgery alone for carcinomas of the major salivary glands in an attempt to evaluate the potential role of postoperative radiation therapy.
  • METHODS AND MATERIALS: Between 1960 and 2004, 207 patients with carcinomas of the major salivary glands were treated with definitive surgery without postoperative radiation therapy.
  • Histology was: 67 mucoepidermoid (32%), 50 adenoid cystic (24%), 34 acinic cell (16%), 23 malignant mixed (11%), 16 adenocarcinoma (8%), 6 oncocytic (3%), 6 myoepithelial (3%), and 5 other (2%).
  • CONCLUSION: Lymph node metastasis, high tumor grade, positive margins, and T3-4 stage predict for significant rates of LRR after surgery for carcinomas of the major salivary glands.
  • [MeSH-major] Carcinoma / secondary. Carcinoma / surgery. Neoplasm Recurrence, Local. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / surgery

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  • (PMID = 17241753.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Prabhu S, Kaveri H, Rekha K: Benign, malignant salivary gland tumors: comparison of immunohistochemical expression of e-cadherin. Oral Oncol; 2009 Jul;45(7):594-9
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  • [Title] Benign, malignant salivary gland tumors: comparison of immunohistochemical expression of e-cadherin.
  • The aim of the present study was to assess any variation in the immunohistochemical expression of E-cadherin in benign and malignant salivary gland tumors.
  • A total of 60 cases of benign and malignant salivary gland tumors were evaluated immunohistochemically for E-cadherin expression.
  • These included 10 cases of pleomorphic adenoma (PA), 2 cases of canalicular adenoma (CA), 2 cases of myoepithelioma (MY), 24 cases of adenoid cystic carcinoma (ACC), 12 cases of mucoepidermoid carcinoma (MEC), 9 cases of adenocarcinoma (AC) and 1 case of carcinoma ex pleomorphic adenoma (Ca Ex PA).
  • Statistically significant reduction in reactivity was evident in mucoepidermoid carcinoma and adenocarcinoma, when compared to pleomorphic adenoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cadherins / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / metabolism. Case-Control Studies. Humans. Myoepithelioma / metabolism

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  • (PMID = 18955011.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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53. Attlmayr B, Garrido C, Alderson DJ: Difficulty in establishing a diagnosis in an uncommon presentation of a minor salivary gland tumour. BMJ Case Rep; 2010;2010
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  • [Title] Difficulty in establishing a diagnosis in an uncommon presentation of a minor salivary gland tumour.
  • We report the case of a man presenting with a large, airway obstructing, minor salivary gland tumour arising from the right tonsillar base.
  • A firm diagnosis of malignancy could not be made histologically.
  • The differential diagnosis included polymorphous low-grade adenocarcinoma, basal cell adenoma and adenoid cystic carcinoma.
  • However, on balance, based on the clinical presentation, a diagnosis of malignancy was favoured and appropriate treatment was considered.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / pathology. Airway Obstruction / etiology. Deglutition Disorders / etiology. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Cooperative Behavior. Diagnosis, Differential. Endoscopy. Humans. Interdisciplinary Communication. Lymphatic Metastasis / pathology. Lymphatic Metastasis / radiotherapy. Magnetic Resonance Imaging. Male. Middle Aged. Palliative Care. Tongue / pathology. Tracheostomy

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  • [Cites] Oral Dis. 2002 Sep;8(5):229-40 [12363107.001]
  • [Cites] Am J Surg. 1991 Oct;162(4):330-6 [1659242.001]
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  • (PMID = 22798299.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC3029651
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54. Manoharan M, Gomez P, Reyes MA, Soloway MS: Metastatic adenoid cystic carcinoma to the kidney in a young woman. Urology; 2006 Dec;68(6):1343.e11-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adenoid cystic carcinoma to the kidney in a young woman.
  • The incidence of an adenoid cystic carcinoma on major salivary glands is low, constituting only about 10% to 15% of all parotid malignancies.
  • We present the case of a 21-year-old woman with a left renal metastasis from an adenoid cystic carcinoma of the parotid gland that had been surgically treated 7 years previously.
  • During follow-up, the patient developed pulmonary nodules that were metastatic adenoid cystic carcinoma and were surgically excised.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Kidney Neoplasms / secondary. Parotid Neoplasms / pathology

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  • (PMID = 17141832.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Cavalcante RB, Lopes FF, Ferreira AS, Freitas Rde A, de Souza LB: Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors. Braz Dent J; 2007;18(3):192-7
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  • [Title] Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors.
  • In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calponin and HHF-35 was applied to 28 salivary gland tumors.
  • The cells predominantly stained by all tested antibodies included nonluminal cells in duct-like and tubular structures, such as those seen in pleomorphic adenomas and adenoid cystic carcinomas, as well as cells in the cords and nests of polymorphous low-grade adenocarcinomas and peripheral cells of sheets and nests of myoepitheliomas.
  • In conclusion, the combination of calponin and vimentin is suggested for the identification of myoepithelial cells in salivary gland tumors.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Muscle Proteins / metabolism. Myoepithelioma / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 18176708.001).
  • [ISSN] 1806-4760
  • [Journal-full-title] Brazilian dental journal
  • [ISO-abbreviation] Braz Dent J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / Microfilament Proteins; 0 / Muscle Proteins; 0 / Vimentin; 0 / calponin
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56. Florentine BD, Fink T, Avidan S, Braslavsky D, Raza A, Cobb CJ: Extra-salivary gland presentations of adenoid cystic carcinoma: a report of three cases. Diagn Cytopathol; 2006 Jul;34(7):491-4
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  • [Title] Extra-salivary gland presentations of adenoid cystic carcinoma: a report of three cases.
  • Adenoid cystic carcinoma (ACC) is a malignant neoplasm most commonly originating in salivary glands of the head and neck area.
  • When ACC presents outside of these locations, the diagnosis may become more challenging.
  • We describe three cases of ACC presenting in extra-salivary gland sites.
  • In conclusion, ACC can present in various body sites and cytologists must consider this neoplasm when presented with a basaloid carcinoma of uncertain origin.
  • [MeSH-major] Bone Neoplasms / secondary. Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Pleural Effusion / pathology

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16783770.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Fiorella R, Di Nicola V, Fiorella ML, Spinelli DA, Coppola F, Luperto P, Madami L: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital; 2005 Jun;25(3):182-90
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  • [Title] Major salivary gland diseases. Multicentre study.
  • Malignant tumours instead were fewer in number compared to the literature (14% vs 25-30%); the most frequent being mucoepidermoid carcinoma (18.2%) of which 44% G1, 33% G2 and 23% G3.
  • Adenoid-cystic carcinoma was observed in 15.3% and < or = 10% for all the other most frequent histological malignant neoplasms.
  • Oncological results obtained were compared with those reported in the literature: in fact for all benign neoplasms relapse ratings are about 5%, while for malignant tumours the worst prognosis was in squamous cell carcinoma with median of 37.7 on survival and metastasis rate of 16.5%.
  • Finally, mucoepidermoid carcinoma tumours showed best survival, followed by adenoid-cystic carcinoma with ranges, respectively, 83 and 81.
  • [MeSH-major] Salivary Gland Neoplasms

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  • [ErratumIn] Acta Otorhinolaryngol Ital. 2005 Oct;25(5):following 337
  • (PMID = 16450775.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639866
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58. Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Villaret DB: Radiotherapy alone or combined with surgery for salivary gland carcinoma. Cancer; 2005 Jun 15;103(12):2544-50
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  • [Title] Radiotherapy alone or combined with surgery for salivary gland carcinoma.
  • BACKGROUND: The authors analyzed the outcomes of patients treated with radiotherapy (RT) alone or combined with surgery for carcinoma of the salivary glands.
  • CONCLUSIONS: A substantial proportion of patients with salivary gland carcinoma were cured with surgery combined with adjuvant RT.
  • [MeSH-major] Salivary Gland Neoplasms / radiotherapy. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / radiotherapy. Carcinoma, Mucoepidermoid / surgery. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Survival Rate. Treatment Outcome

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  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 15880750.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Kazakov DV, Zelger B, Rütten A, Vazmitel M, Spagnolo DV, Kacerovska D, Vanecek T, Grossmann P, Sima R, Grayson W, Calonje E, Koren J, Mukensnabl P, Danis D, Michal M: Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol; 2009 May;33(5):705-19
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  • 1) salivary gland type basal cell adenocarcinoma-like pattern, low-grade (BCAC-LG);.
  • 2) salivary gland type basal cell adenocarcinoma-like pattern, high-grade (BCAC-HG);.
  • 3) invasive adenocarcinoma, not otherwise specified (IAC-NOS); and 4) sarcomatoid (metaplastic) carcinoma.
  • In 1 case of IAC-NOS, an in situ adenocarcinoma was also found, presumed to have evolved from an adjacent adenomatous and atypical adenomatous component.
  • Cases harboring a sarcomatoid carcinoma featured a malignant epithelial component composed of varying combinations of BCAC-HG, BCAC-LG, IAC-NOS, or squamous cell carcinoma, whereas the sarcomatoid component appeared as either a pleomorphic or spindle-cell sarcoma.
  • Patients with sarcomatoid carcinoma had a relatively good survival.
  • Given the morphologic diversity and complexity of the neoplasms in question, we propose using a more specific terminology with the precise description of the neoplasm components, rather than generic and less informative terms such as "spiradenocarcinoma" or "carcinoma ex cylindroma. "
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Australia. Carcinoma, Skin Appendage / pathology. Carcinoma, Squamous Cell / pathology. Cell Differentiation. Chromosomes, Human, Pair 16. Europe. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Metaplasia. Middle Aged. Mutation. Neoplasm Invasiveness. South Africa. Syndrome. Treatment Outcome. Tumor Suppressor Proteins / genetics


60. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V: Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol; 2008 Mar-Apr;29(2):142-6
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  • Ceruminal glands are modified sweat glands of the skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
  • An alternative theory holds that pleomorphic adenomas may well arise from ectopic salivary tissue present in the external ear canal.
  • Magnetic resonance imaging showed no intracranial extension or any association with the adjacent parotid gland.
  • Nonspecific presentation and difficult histologic diagnosis characterize this benign neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear, External / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18314029.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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61. Shahsavari F, Eslami M, Baghaie F, Tirgari F, Motahhary P: Immunohistochemical evaluation of p27 (kip1) in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands. Asian Pac J Cancer Prev; 2005 Oct-Dec;6(4):527-30
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  • [Title] Immunohistochemical evaluation of p27 (kip1) in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands.
  • In this study, p27 expression was investigated in pleomorphic adenomas (PAs) and adenoid cystic carcinomas (ACCs) of minor salivary glands to evaluate its utility for differentiation purposes.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Carcinoma, Adenoid Cystic / metabolism. Cyclin-Dependent Kinase Inhibitor p27 / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Glands, Minor
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Iran. Male. Middle Aged

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  • (PMID = 16436005.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
  • [Chemical-registry-number] 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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62. Whatley WS, Thompson JW, Rao B: Salivary gland tumors in survivors of childhood cancer. Otolaryngol Head Neck Surg; 2006 Mar;134(3):385-8
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  • [Title] Salivary gland tumors in survivors of childhood cancer.
  • The most common second malignancies are acute leukemia, bone and soft tissue tumors, and carcinoma of the skin, breast, and thyroid.
  • Although, ionizing radiation has been demonstrated to increase the risk of developing a salivary gland neoplasm, there are few reports of salivary gland neoplasms occurring in patients treated for cancer in childhood.
  • RESULTS: Twelve survivors of childhood cancer developed a salivary gland neoplasm after completion of treatment.
  • The pathology of the salivary gland tumors were mucoepidermoid carcinoma (10), adenoid cystic carcinoma (1) , and pleomorphic adenoma (1).
  • CONCLUSION: Radiation and chemotherapy used to treat patients with childhood malignancies increases the risk of developing a second neoplasm of salivary gland origin.
  • The majority of these neoplasms are malignant; mucoepidermoid carcinoma occurs most frequently.
  • [MeSH-major] Neoplasms, Second Primary / diagnosis. Salivary Gland Neoplasms / diagnosis. Survivors
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / surgery. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis / diagnosis. Male. Neck Dissection. Neoplasms / drug therapy. Neoplasms / radiotherapy. Radiotherapy, Adjuvant. Registries. Retrospective Studies. Risk Factors


63. Wegner A, Waśniewska E, Jarmołowska-Jurczyszyn D, Golusiński W, Biczysko W: [The role of immunohistochemical staining (protein p53, cyclin D1) in the prognosis of adenoid cystic carcinoma salivary gland tumors]. Otolaryngol Pol; 2007;61(4):423-7
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  • [Title] [The role of immunohistochemical staining (protein p53, cyclin D1) in the prognosis of adenoid cystic carcinoma salivary gland tumors].
  • [Transliterated title] Rola badań immunohistochemicznych (białka p53, cykliny D1) w prognozowaniu raka gruczołowato-torbielowatego (carcinoma adenoides cysticum) ślinianek.
  • INTRODUCTION: Adenoid cystic carcinoma of the salivary glands (carcinoma adenoides cysticum) is malignant epithelial tumor of rare occurrence.
  • Tumor of this kind has among salivary glands tumors uncertain prognosis and unpredictable course.
  • MATERIAL AND METHODS: The examined group consisted of 30 patients with adenoid cystic carcinoma of the salivary glands.
  • There was not statistically significant difference between the advanced grading of the organic and clinical adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Cyclin D1 / biosynthesis. Salivary Gland Neoplasms / diagnosis. Tumor Suppressor Protein p53 / biosynthesis


64. Dardick I, Daley TD, McComb RJ: Sialoblastoma in adults: distinction from adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jan;109(1):109-16
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  • [Title] Sialoblastoma in adults: distinction from adenoid cystic carcinoma.
  • No adult cases have been reported with a specific diagnosis of sialoblastoma.
  • If even focal cribriforming were present, such cases have undoubtedly been diagnosed as adenoid cystic carcinoma.
  • Each case, however, has the primitive histopathology with discrete nests of basaloid tumor cells, associated bilayered ductal structures and the fibromyxoid stroma characteristic for sialoblastoma with its resemblance to fetal salivary gland or salivary gland with arrested development.
  • Sialoblastoma, whether in a child or adult with or without a cribriform growth pattern, appears to have a more favorable prognosis than adenoid cystic carcinoma.
  • Aspects of the histological differential diagnosis of these 2 tumors are discussed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Palatal Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Facial Paralysis / etiology. Female. Humans. Male. Middle Aged. Palate, Hard / pathology. Parotid Neoplasms / complications. Parotid Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 19880331.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Vidal L, Tsao MS, Pond GR, Cohen EE, Cohen RB, Chen EX, Agulnik M, Hotte S, Winquist E, Laurie S, Hayes DN, Ho J, Dancey J, Siu LL: Fluorescence in situ hybridization gene amplification analysis of EGFR and HER2 in patients with malignant salivary gland tumors treated with lapatinib. Head Neck; 2009 Aug;31(8):1006-12
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  • [Title] Fluorescence in situ hybridization gene amplification analysis of EGFR and HER2 in patients with malignant salivary gland tumors treated with lapatinib.
  • BACKGROUND: Gene amplification status of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2) were analyzed and correlated with clinical outcome in patients with progressive malignant salivary glands tumors (MSGT) treated with the dual EGFR/Her2 tyrosine kinase inhibitor lapatinib.
  • METHODS: Fluorescence in situ hybridization (FISH) analysis for both EGFR and HER2 gene amplification was performed successfully in the archival tumor specimens of 20 patients with adenoid cystic carcinomas (ACC) and 17 patients with non-ACC, all treated with lapatinib.

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  • [Copyright] Copyright 2009 Wiley Periodicals, Inc.
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  • (PMID = 19309723.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CM / CM062203; United States / NCI NIH HHS / CA / U01 CA132123-01; United States / NCI NIH HHS / CA / CA132123-01; United States / NCI NIH HHS / CM / N01-CM-62203; United States / NCI NIH HHS / CM / N01-CM-57018-16; United States / NCI NIH HHS / CA / U01 CA132123; United States / NCI NIH HHS / CA / N01CM62203; United States / NCI NIH HHS / CM / N01 CM062203
  • [Publication-type] Clinical Trial, Phase II; Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Quinazolines; 0VUA21238F / lapatinib; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
  • [Other-IDs] NLM/ NIHMS95592; NLM/ PMC2711990
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71. Epivatianos A, Iordanides S, Zaraboukas T, Antoniades D: Adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of minor salivary glands: a comparative immunohistochemical study using the epithelial membrane and carcinoembryonic antibodies. Oral Dis; 2005 May;11(3):175-80
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  • [Title] Adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of minor salivary glands: a comparative immunohistochemical study using the epithelial membrane and carcinoembryonic antibodies.
  • OBJECTIVE: The purpose of this study was to investigate immunohistochemically the expression of epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA) in adenoid cystic carcinoma (AdCC) and polymorphous low-grade adenocarcinoma (PLGA) in an attempt to assess the ability of these markers to distinguish AdCC from PLGA when the histological features on routine hematoxylin and eosin are equivocal.
  • MATERIALS AND METHODS: Fourteen specimens of AdCC, 10 PLGA, and five normal minor salivary glands fixed in 10% formalin and embedded in paraffin, were retrieved from the files of our department and were retrospectively studied with the streptavidin-biotin complex method using the epithelial membrane and carcinoembryonic antibodies.
  • CONCLUSIONS: The results of this study suggest that the immunostaining of AdCC and PLGA with EMA and CEA could not offer an adjunctive aid in differential diagnosis between these two tumors.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoembryonic Antigen / analysis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Mucin-1 / analysis. Retrospective Studies. Salivary Gland Diseases / diagnosis. Salivary Glands, Minor


72. Ihrler S, Schwarz S, Zengel P, Guntinas-Lichius O, Kirchner T, Weiler C: [Pleomorphic adenoma: pitfalls and clinicopathological forms of progression]. Pathologe; 2009 Nov;30(6):446-56
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  • [Transliterated title] Das pleomorphe Adenom: Pitfalls in der Diagnostik und klinisch-pathologische Progressionsformen.
  • In the majority of cases the diagnosis of pleomorphic adenoma (PA) is straightforward.
  • Focal peripheral pseudoinfiltration can represent physiological growth pattern of PA; this may render a difficult distinction from low-malignant carcinomas like adenoid-cystic or epithelial-myoepithelial carcinoma, harbouring also tubular structures.
  • The different progression steps of carcinoma ex pleomorphic adenoma (CEPA), starting with intraductal carcinoma, are highly relevant with respect to prognosis and therapy.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Disease Progression. Female. Humans. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Reoperation. Salivary Ducts / pathology. Salivary Glands / pathology

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  • (PMID = 19844715.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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73. Westernoff TH, Jordan RC, Regezi JA, Ramos DM, Schmidt BL: Beta-6 Integrin, tenascin-C, and MMP-1 expression in salivary gland neoplasms. Oral Oncol; 2005 Feb;41(2):170-4
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  • [Title] Beta-6 Integrin, tenascin-C, and MMP-1 expression in salivary gland neoplasms.
  • The objective of this study was to determine whether there is overexpression of these molecules in three types of salivary neoplasms showing markedly different behavior.
  • A total of 55 formalin-fixed, paraffin-embedded archived specimens comprising 19 adenoid cystic carcinomas (ACC), 18 polymorphous low-grade adenocarcinomas (PLGA) and 18 pleomorphic adenomas (PA) were utilized in this study.
  • No significant difference was observed between ACCs and PLGAs. beta-6 expression was rarely seen in normal salivary gland epithelium and was occasionally present in mucosa overlying the tumors.
  • We believe that beta-6, tenascin-C, and MMP-1 proteins are part of the molecular repertoire used by salivary tumors for malignant invasion and benign tumor expansion.
  • [MeSH-major] Integrin beta Chains / metabolism. Matrix Metalloproteinase 1 / metabolism. Neoplasm Proteins / metabolism. Salivary Gland Neoplasms / metabolism. Tenascin / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenoma / metabolism. Carcinoma, Adenoid Cystic / metabolism. Humans. Immunohistochemistry / methods

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  • (PMID = 15695119.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Grant] United States / PHS HHS / / 11RT-0141; United States / PHS HHS / / 12KT-0166; United States / NCI NIH HHS / CA / CA095231; United States / NIDCR NIH HHS / DE / DE14609; United States / NIDCR NIH HHS / DE / K23DE00443; United States / NIDCR NIH HHS / DE / P01DE13904; United States / NIDCR NIH HHS / DE / R0I DE12856; United States / NIDCR NIH HHS / DE / R0I DEO11930
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Integrin beta Chains; 0 / Neoplasm Proteins; 0 / Tenascin; 0 / integrin beta6; EC 3.4.24.7 / Matrix Metalloproteinase 1
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74. Ma J, Wang J, Zhong M, Wang ZY: [Effects of genistein on the expressions of cell cycle proteins in salivary adenoid cystic carcinoma cell line SACC-83]. Shanghai Kou Qiang Yi Xue; 2006 Feb;15(1):69-72
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  • [Title] [Effects of genistein on the expressions of cell cycle proteins in salivary adenoid cystic carcinoma cell line SACC-83].
  • PURPOSE: To investigate the molecular mechanism of cell cycle arrest induced by tyrosine protein kinase inhibitor, genistein, in human salivary adenoid cystic carcinoma cell line SACC-83.
  • Treated with 220 micromol/L of genistein for 3 days, the expression level of CyclinB1, Cdk1, CyclinD1 and Cdk4 proteins was 58%, 64%, 46% and 43% of the control group, respectively (P<0.01).
  • CONCLUSION: The cell cycle G2/M arrest induced by genistein in human salivary adenoid cystic carcinoma cell line SACC-83 may be associated with the downregulations of CyclinB1, Cdk1, CyclinD1 and Cdk4 protein expressions.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Cell Cycle Proteins / drug effects. Genistein / pharmacology. Salivary Gland Neoplasms / metabolism

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  • (PMID = 16525614.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; DH2M523P0H / Genistein; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4
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75. Costa AF, Demasi AP, Bonfitto VL, Bonfitto JF, Furuse C, Araújo VC, Metze K, Altemani A: Angiogenesis in salivary carcinomas with and without myoepithelial differentiation. Virchows Arch; 2008 Oct;453(4):359-67
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  • [Title] Angiogenesis in salivary carcinomas with and without myoepithelial differentiation.
  • To investigate whether salivary carcinomas with and without myoepithelial differentiation could present differences regarding degree of angiogenesis, we compared tumor vascularization between adenoid cystic (31 cases) and epithelial-myoepithelial carcinomas (14) versus mucoepidermoid (37) carcinoma.
  • The reasons for this lower angiogenic activity remain to be determined but could be related to metabolic characteristics of the cancer cells.
  • [MeSH-major] Neovascularization, Pathologic / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Cell Differentiation. Endoglin. Female. Humans. Male. Middle Aged. Myoepithelioma / pathology. Receptors, Cell Surface / metabolism

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  • (PMID = 18795324.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / ENG protein, human; 0 / Endoglin; 0 / Receptors, Cell Surface
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76. Saghravanian N, Mohtasham N, Jafarzadeh H: Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. J Oral Sci; 2009 Dec;51(4):509-14
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  • [Title] Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
  • Adenoid cystic carcinoma (AdCC) and polymorphous low-grade adenocarcinoma (PLGA) have several common histological and clinicopathological features that may create diagnostic difficulties.
  • In this study, 10 AdCCs, 8 PLGAs, and 5 normal minor salivary glands as a control group were selected.
  • Thus, immunohistochemistry can be helpful for differential diagnosis of AdCC and PLGA, particularly that for CEA, vimentin, and Ki-67.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor. Carcinoma, Adenoid Cystic / chemistry. Salivary Gland Neoplasms / chemistry
  • [MeSH-minor] Carcinoembryonic Antigen / analysis. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Ki-67 Antigen / analysis. Vimentin / analysis


77. Fukuda M, Hiroi M, Suzuki S, Ohmori Y, Sakashita H: Loss of CYLD might be associated with development of salivary gland tumors. Oncol Rep; 2008 Jun;19(6):1421-7
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  • [Title] Loss of CYLD might be associated with development of salivary gland tumors.
  • We demonstrated previously that human salivary gland tumor (SGT) cell line, HSG spontaneously expresses CYLD and also found that adenoid cystic carcinoma (ACC) arising from the hard palate was distinctly positive for CYLD, immunohistochemically.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Genes, Tumor Suppressor / physiology. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 18497946.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / NF-kappa B; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Transcription Factor RelA; 0 / Tumor Necrosis Factor-alpha; 0 / Tumor Suppressor Proteins; EC 2.7.11.10 / I-kappa B Kinase
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78. Xie W, Li X, Ren G, Guo W: Expression and importance of inhibitor of DNA binding helix-loop-helix protein in salivary adenoid cystic carcinoma. Br J Oral Maxillofac Surg; 2010 Sep;48(6):434-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and importance of inhibitor of DNA binding helix-loop-helix protein in salivary adenoid cystic carcinoma.
  • However, the role of Id-1 protein in salivary adenoid cystic carcinoma (ACC) is not clear.
  • Thirty-nine of the 54 specimens of ACC stained for Id-1expression, which was significantly more than was found in pleomorphic adenomas (4/12) and normal salivary gland tissues (1/10, p<0.05).
  • Our results showed that Id-1 may have important roles in the development of salivary ACC.
  • It might also be a useful therapeutic tool to help prevent salivary ACC or to inhibit its malignant progression.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Gene Expression Regulation, Neoplastic. Inhibitor of Differentiation Protein 1 / biosynthesis. Salivary Gland Neoplasms / metabolism

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  • [Copyright] Copyright 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19766362.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Inhibitor of Differentiation Protein 1
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79. Till BG, Martins RG: Response to paclitaxel in adenoid cystic carcinoma of the salivary glands. Head Neck; 2008 Jun;30(6):810-4
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  • [Title] Response to paclitaxel in adenoid cystic carcinoma of the salivary glands.
  • BACKGROUND: Paclitaxel is not considered to be an active drug in adenoid cystic carcinoma (ACC) of the salivary glands.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Lung Neoplasms / drug therapy. Paclitaxel / therapeutic use. Salivary Gland Neoplasms / drug therapy

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  • (PMID = 17979110.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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80. He HB, Tang XF, Li LJ, Li L, Hua CG: [Effect of mechanical stimulation on the expression of E-cadherin/cateninin complex in salivary adenoid cystic carcinoma]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2007 Feb;25(1):29-32
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  • [Title] [Effect of mechanical stimulation on the expression of E-cadherin/cateninin complex in salivary adenoid cystic carcinoma].
  • OBJECTIVE: To investigate the effects of cyclic biaxial mechanical stimulation on adhesion of salivary adenoid cystic carcinoma(SACC) extracellular matrix (ECM) and expression of E-cadherin/cateninin complex in the SACC high metastasis cell lines ACC-M, SACC low metastasis cells line ACC-2, we observed the functions of mechanical stimulation in the adhesion of SACC cell-ECM and investigate the mechanism in the adhesion of ACC.
  • We think it played an important role in metastasis of the cancer.
  • [MeSH-major] Cadherins. Carcinoma, Adenoid Cystic
  • [MeSH-minor] Humans. Salivary Gland Neoplasms

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  • (PMID = 17375572.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cadherins
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81. Nong XL, Xia Y, Yang YP, Qing HY, Li JQ, Li YN, Cao Y, Li H, Chen Q: [Tyrosine kinase A and vascular endothelial growth factor receptor 2 in the invasion and metastasis of salivary adenoid cystic carcinoma]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2010 Aug;28(4):420-4, 429
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  • [Title] [Tyrosine kinase A and vascular endothelial growth factor receptor 2 in the invasion and metastasis of salivary adenoid cystic carcinoma].
  • OBJECTIVE: To determine the effect of tyrosine kinase A (TrkA) and vascular endothelial growth factor receptor 2 (VEGFR2) in the invasion and metastasis of salivary adenoid cystic carcinoma (SACC).
  • METHODS: The expression of TrkA and VEGFR2 were detected by immunohistochemical staining in 47 cases of SACC of salivary glands.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Receptor, trkA / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 20848939.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, trkA; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
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82. Tang Y, Liang X, Zhu G, Zheng M, Yang J, Chen Y: Expression and importance of zinc-finger transcription factor Slug in adenoid cystic carcinoma of salivary gland. J Oral Pathol Med; 2010 Nov;39(10):775-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and importance of zinc-finger transcription factor Slug in adenoid cystic carcinoma of salivary gland.
  • However, there is little information on the expression and role of Slug in salivary adenoid cystic carcinoma (ACC).
  • METHOD: Demographic variables and primary tumor site, dates of diagnoses, perineural invasion, local regional recurrence, and distant metastasis of 121 cases of salivary ACC treated at the Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University between 1996 and 2005 were retrieved.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology. Transcription Factors / metabolism. Zinc Fingers / physiology

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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 20738754.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Transcription Factors; 0 / snail family transcription factors
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83. Nagliati M, Bolner A, Vanoni V, Tomio L, Lay G, Murtas R, Deidda MA, Madeddu A, Delmastro E, Verna R, Gabriele P, Amichetti M: Surgery and radiotherapy in the treatment of malignant parotid tumors: a retrospective multicenter study. Tumori; 2009 Jul-Aug;95(4):442-8
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  • AIMS AND BACKGROUND: Major salivary gland cancers are rare, with many histologic types and subtypes.
  • The most frequent histologies were adenoid cystic carcinoma (n = 16), mucoepidermoid carcinoma (n = 15), and acinic cell carcinoma (n = 15).
  • CONCLUSIONS: The treatment of salivary gland malignancies remains primarily surgical.

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  • (PMID = 19856654.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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84. Wenghoefer M, Pantelis A, Dommisch H, Götz W, Reich R, Bergé S, Martini M, Allam JP, Jepsen S, Merkelbach-Bruse S, Fischer HP, Novak N, Winter J: Nuclear hBD-1 accumulation in malignant salivary gland tumours. BMC Cancer; 2008;8:290
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nuclear hBD-1 accumulation in malignant salivary gland tumours.
  • Therefore this study was conducted to characterise proteins involved in cell cycle control and host defence in different benign and malignant salivary gland tumours in comparison with healthy salivary gland tissue.
  • METHODS: 21 paraffin-embedded tissue samples of benign (n = 7), and malignant (n = 7) salivary gland tumours as well as healthy (n = 7) salivary glands were examined immunohistochemically for the expression of p53, bcl-2, and hBD-1, -2, -3.
  • RESULTS: HBD-1 was distributed in the cytoplasm of healthy salivary glands and benign salivary gland tumours but seems to migrate into the nucleus of malignant salivary gland tumours.
  • CONCLUSION: HBD-1, 2 and 3 are traceable in healthy salivary gland tissue as well as in benign and malignant salivary gland tumours.
  • As hBD-1 is shifted from the cytoplasm to the nucleus in malignant salivary gland tumours, we hypothesize that it might play a role in the oncogenesis of these tumours.
  • [MeSH-major] Cell Nucleus / metabolism. Salivary Gland Neoplasms / metabolism. beta-Defensins / metabolism
  • [MeSH-minor] Adenoma, Pleomorphic / metabolism. Carcinoma, Adenoid Cystic / metabolism. Case-Control Studies. Cytoplasm / metabolism. Female. Gene Expression. Humans. Immunohistochemistry. Male. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / metabolism. Salivary Glands / metabolism. Salivary Glands / pathology. Tumor Suppressor Protein p53 / metabolism

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  • [Cites] Oncogene. 2000 Jan 20;19(3):373-9 [10656684.001]
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  • (PMID = 18840281.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DEFB1 protein, human; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / beta-Defensins
  • [Other-IDs] NLM/ PMC2567991
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85. De Dosso S, Mazzucchelli L, Ghielmini M, Saletti P: Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma. Tumori; 2009 May-Jun;95(3):378-81
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  • [Title] Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma.
  • Esophageal localization of adenoid cystic carcinoma of minor salivary glands is rare; it may occur in the early to mid-sixties' age group and is more frequently encountered in men than women.
  • In the majority of cases, it arises from subepithelial glands of the middle to lower third of the esophagus, a similar distribution as squamous cell carcinoma.
  • We report a case of a patient with metastatic primary esophageal adenoid cystic carcinoma progressing on platinum- and irinotecan-based regimens, who achieved an objective response with oxaliplatin-based chemotherapy in combination with cetuximab.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / secondary. Esophageal Neoplasms / pathology. Salivary Gland Neoplasms / drug therapy. Salivary Gland Neoplasms / secondary

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  • (PMID = 19688981.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Biomarkers, Tumor; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; PQX0D8J21J / Cetuximab
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86. Daa T, Yada N, Kashima K, Suzuki M, Yokoyama S: Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland. Mol Med Rep; 2009 Jan-Feb;2(1):13-5
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  • [Title] Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland.
  • SMAD4, also known as DPC4 (deleted in pancreatic carcinoma 4) was initially identified as a tumor-suppressor gene.
  • It is located on 18q21, a region frequently deleted in pancreatic carcinoma.
  • Functionally inactivating mutation of the gene also occurs in many cases of pancreatic cancer.
  • Functional loss of SMAD4 is frequently detected not only in pancreatic carcinoma but also in colorectal carcinoma.
  • The purpose of this study was to elucidate the role of SMAD4 in adenoid cystic carcinoma of the salivary glands.
  • We examined 34 cases of adenoid cystic carcinoma for loss of heterozygosity (LOH) of the SMAD4 locus and for the existence of mutations of the gene.
  • In conclusion, the infrequent LOH of the SMAD4 gene locus and lack of SMAD4 mutations indicate that SMAD4 does not play a role in the tumorigenesis of adenoid cystic carcinoma of the salivary gland.

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  • (PMID = 21475783.001).
  • [ISSN] 1791-2997
  • [Journal-full-title] Molecular medicine reports
  • [ISO-abbreviation] Mol Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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87. Sun ZJ, Chen G, Hu X, Zhang W, Liu Y, Zhu LX, Zhou Q, Zhao YF: Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin. Apoptosis; 2010 Jul;15(7):850-63
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  • [Title] Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin.
  • The present study was to investigate the effects of quercetin on growth and apoptosis in human salivary adenoid cystic carcinoma (ACC).
  • [MeSH-major] Antineoplastic Agents / toxicity. Apoptosis. Carcinoma, Adenoid Cystic / metabolism. Quercetin / toxicity. Salivary Gland Neoplasms / metabolism. Signal Transduction / drug effects

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  • (PMID = 20386985.001).
  • [ISSN] 1573-675X
  • [Journal-full-title] Apoptosis : an international journal on programmed cell death
  • [ISO-abbreviation] Apoptosis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / NF-kappa B; 0 / Proto-Oncogene Proteins c-bcl-2; 9007-43-6 / Cytochromes c; 9IKM0I5T1E / Quercetin; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.10 / I-kappa B Kinase; EC 3.4.22.- / Caspases
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88. Wang XF, Guo Y, Jia SS: [Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2007 Feb;42(2):78-9
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  • [Title] [Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma].
  • OBJECTIVE: To examine the differential gene expression among adenoid cystic carcinoma ACC-M, low metastasis ACC-2 and low differentiated mucoepidermoid carcinoma MEC-1 with gene array, and detect three important genes with real-time quantitative PCR.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Mucoepidermoid / genetics. Drug Resistance, Neoplasm / genetics. Genes, MDR. Neoplasm Metastasis / genetics. Salivary Gland Neoplasms / genetics

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  • (PMID = 17462150.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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89. Li Y, Li LJ, Huang J, Han B, Pan J: Central malignant salivary gland tumors of the jaw: retrospective clinical analysis of 22 cases. J Oral Maxillofac Surg; 2008 Nov;66(11):2247-53
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  • [Title] Central malignant salivary gland tumors of the jaw: retrospective clinical analysis of 22 cases.
  • PURPOSE: As a review of central malignant salivary gland tumor cases in Southwest China in the past 20 years, this study provided the clinical, radiologic, and pathologic information of these rare lesions.
  • PATIENTS AND METHODS: In our study, 22 cases of central malignant salivary gland tumor treated between 1986 to 2006 at West China Stomatology Hospital of Sichuan University were retrospectively analyzed.
  • A thorough review of clinical records was carried out and the histologic diagnosis was revised using the 2005 WHO criteria.
  • The most frequent histologic type was the mucoepidermoid carcinoma.
  • CONCLUSION: Central malignant salivary gland tumors often occurred in the middle-aged patients, and there were more cases in the mandible than in the maxilla.
  • The diagnosis should be based on the case history, clinical, pathologic, and radiologic examinations.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Jaw Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Carcinoma / pathology. Carcinoma / radiography. Carcinoma / surgery. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / radiography. Carcinoma, Adenoid Cystic / surgery. China. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 18940488.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Götte K, Ganssmann S, Affolter A, Schäfer C, Riedel F, Arens N, Finger S, Hörmann K: Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses. Oncol Rep; 2005 Nov;14(5):1103-7
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  • [Title] Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses.
  • To date, the underlying genomic changes in benign and malignant tumors of salivary-gland and paranasal-sinus origin are poorly understood.
  • We examined 58 of these tumors (14 adenoid cystic carcinomas, 9 adenocarcinomas, 5 cylindrical carcinomas, 11 pleomorphic adenomas, and 19 inverted papillomas) by dual fluorescence in situ hybridization (FISH) with centromere-specific probes on six chromosomes (3, 7, 9, 11, 17, and 18) for numerical changes.
  • In adenoid cystic carcinomas, monosomy of chromosome 17 and polysomy of chromosomes 3, 9 and 11 were most frequently encountered.
  • In summary, the occurrence of polysomy might reflect a step towards malignancy in tumors of the salivary glands and paranasal mucosa.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. Adenoma / diagnosis. Adenoma / genetics. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / genetics. Chromosome Aberrations. Papilloma / diagnosis. Papilloma / genetics. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Diagnosis, Differential. Humans. In Situ Hybridization, Fluorescence. Salivary Gland Diseases / diagnosis. Salivary Gland Diseases / genetics

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  • (PMID = 16211271.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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91. Tian Z, Zhang ZY, Li L, Li J: [Expression of DNA methyltransferases in salivary adenoid cystic carcinoma and its association with the CpG islands methylation of tumor suppressor genes]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2006 Jul;41(7):411-5
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  • [Title] [Expression of DNA methyltransferases in salivary adenoid cystic carcinoma and its association with the CpG islands methylation of tumor suppressor genes].
  • OBJECTIVE: To investigate the role of DNA methyltransferases (DNMT) in carcinogenesis and development of salivary adenoid cystic carcinoma (ACC) by detection the expression of DNMT in ACC and to assess its correlation to methylation of tumor suppressor genes and biological behavior of ACC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. CpG Islands. DNA (Cytosine-5-)-Methyltransferase / metabolism. DNA Methylation. Repressor Proteins / metabolism. Salivary Gland Neoplasms / genetics

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  • (PMID = 17067458.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DMAP1 protein, human; 0 / Repressor Proteins; EC 2.1.1.37 / DNA (Cytosine-5-)-Methyltransferase; EC 2.1.1.37 / DNA methyltransferase 3B
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92. Keikhaee MR, Kudo Y, Siriwardena S, Wu L, Ogawa I, Takata T: Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid cystic carcinoma. Virchows Arch; 2007 May;450(5):567-74
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  • [Title] Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid cystic carcinoma.
  • Adenoid cystic carcinoma (ACC) is a malignant salivary gland tumor, which shows frequent recurrence and metastasis, ultimately with a poor outcome.
  • These findings, overall, suggest that Skp2 may play an important role in ACC development through the down-regulation of p27 and that Skp2 siRNA can be a novel modality of cancer gene therapy for suppression of p27 down-regulation in ACC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Cell Proliferation. Cyclin-Dependent Kinase Inhibitor p27 / metabolism. S-Phase Kinase-Associated Proteins / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17431674.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proliferating Cell Nuclear Antigen; 0 / RNA, Small Interfering; 0 / S-Phase Kinase-Associated Proteins; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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93. Guzzo M, Ferrari A, Marcon I, Collini P, Gandola L, Pizzi N, Casanova M, Mattavelli F, Scaramellini G: Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan. Pediatr Blood Cancer; 2006 Nov;47(6):806-10
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  • [Title] Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan.
  • BACKGROUND: Epithelial salivary gland tumors are very uncommon in pediatric age.
  • These results are presented in conjunction with a literature review of salivary tumors with a view to providing an up-to-date overview of the clinical course, prognosis, and treatment options for this rare tumor.
  • PROCEDURE: Fifty-two cases of epithelial salivary tumors were reviewed and the clinical-pathological information concerning tumor characteristics, therapy, and follow-up were collected.
  • RESULTS: The major salivary glands were the main site of tumor occurrence (79% of cases arose in parotid glands); 37 patients had benign tumors (pleomorphic adenoma), 15 had malignant tumors (12 mucoepidermoid carcinoma, 9 low grade).
  • CONCLUSIONS: Epithelial salivary glands tumor in children had different characteristics compared with their adult counterpart with respect to the frequency of histotypes and site of occurrence, but their prognosis seems to be similar.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Carcinoma, Acinar Cell / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / surgery. Neoplasm Recurrence, Local / surgery. Salivary Gland Neoplasms / surgery

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16425245.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Rutherford S, Hampton GM, Frierson HF, Moskaluk CA: Mapping of candidate tumor suppressor genes on chromosome 12 in adenoid cystic carcinoma. Lab Invest; 2005 Sep;85(9):1076-85
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  • [Title] Mapping of candidate tumor suppressor genes on chromosome 12 in adenoid cystic carcinoma.
  • Adenoid cystic carcinoma (ACC) is a common malignancy of salivary glands, for which the underlying genetic mechanisms of tumorigenesis are poorly understood.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Chromosome Mapping. Chromosomes, Human, Pair 12. Genes, Tumor Suppressor. Salivary Gland Neoplasms / genetics

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  • (PMID = 16025147.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / R01-DE-14694
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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95. Vila L, Liu H, Al-Quran SZ, Coco DP, Dong HJ, Liu C: Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland. Mod Pathol; 2009 Oct;22(10):1296-302
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  • [Title] Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.
  • The CD117 (KIT) protein is overexpressed in many human neoplasms including adenoid cystic carcinoma of salivary glands.
  • To evaluate the function of c-kit-activating mutations in adenoid cystic carcinoma of the salivary gland, we studied 14 cases (13 primary, 1 cervical lymph node metastasis) from our institution.
  • Mutational analyses of c-kit extracellular (exon 9), juxtamembrane (exon 11) and tyrosine kinase domains (exons 13 and 17) were performed by polymerase chain reaction, clonal selection and DNA sequencing.
  • This study is the first to report c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.
  • Identification of such potential gain-of-function mutations in exon 11, and less frequently in exons 9, 13 and 17, suggests that KIT may be involved in the pathogenesis of adenoid cystic carcinoma of salivary glands.
  • Our study raises a prospect of correlation of c-kit mutation and a potential treatment of adenoid cystic carcinoma with tyrosine kinase inhibitor (imatinib).

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  • (PMID = 19617878.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK002958; United States / NIDDK NIH HHS / DK / DK02958
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Other-IDs] NLM/ NIHMS490200; NLM/ PMC3746033
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96. Rahman B, Mamoon N, Jamal S, Zaib N, Luqman M, Mushtaq S, Anwar M: Malignant tumors of the minor salivary glands in northern Pakistan: a clinicopathological study. Hematol Oncol Stem Cell Ther; 2008 Apr-Jun;1(2):90-3
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  • [Title] Malignant tumors of the minor salivary glands in northern Pakistan: a clinicopathological study.
  • BACKGROUND: Malignant tumors of the minor salivary glands comprise a small but significant proportion of oral cancers.
  • METHODS: The records of all cases of malignant minor salivary gland tumors diagnosed at the Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan, during a period of 10 years (1994-2003) are described.
  • These included 70 malignant minor salivary gland tumors.
  • The commonest histological type was adenoid cystic carcinoma, constituting 30 cases (42.8%).
  • The next most common type was mucoepidermoid carcinoma comprising 26 (37.1%) cases.
  • There were 2 cases each of polymorphous low-grade adenocarcinoma and clear cell adenocarcinoma.
  • CONCLUSION: Adenoid cystic carcinoma was the commonest malignant neoplasm of the minor salivary glands followed by mucoepidermoid carcinoma.
  • [MeSH-major] Carcinoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 20063536.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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97. Schwentner I, Obrist P, Thumfart W, Sprinzl G: Distant metastasis of parotid gland tumors. Acta Otolaryngol; 2006 Apr;126(4):340-5
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  • [Title] Distant metastasis of parotid gland tumors.
  • The incidence of distant metastasis in head and neck cancer and especially in salivary gland cancer is relatively low in comparison to other malignancies.
  • However, the presence of distant metastasis heralds a poor prognosis in head and neck cancer, with a median survival of 4.3-7.3 months.
  • Patients with malignant salivary gland tumors should have an X-ray or CT scan of the chest at their initial assessment to exclude the possibility of distant metastasis.
  • The likelihood of developing distant metastasis is associated with high-grade tumors, such as adenoid cystic carcinoma, salivary duct carcinoma, high-grade mucoepidermoid carcinoma and tumors located in the submandibular gland, posterior tongue and pharyngeal tumors.
  • A lower risk of developing distant metastasis is known for all other histological entities of salivary gland tumors.
  • Nevertheless all patients who have a histologically confirmed malignant salivary gland tumor should have lifelong follow-up.
  • On the basis of a clinical case regarding a patient with metastatic parotid gland cancer we present a review of the literature.
  • [MeSH-minor] Aged. Bone Neoplasms / secondary. Brain Neoplasms / secondary. Carcinoma, Acinar Cell / pathology. Carcinoma, Acinar Cell / secondary. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / secondary. Carcinoma, Mucoepidermoid / pathology. Carcinoma, Mucoepidermoid / secondary. Fatal Outcome. Humans. Immunohistochemistry. Incidence. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Male. Parotid Gland / pathology. Parotid Gland / surgery. Salivary Ducts / pathology. Tomography, X-Ray Computed

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  • (PMID = 16608783.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 32
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98. Marques MM, Martins MD, França CM: Effect of Matrigel on adenoid cystic carcinoma cell line differentiation. Int J Exp Pathol; 2006 Dec;87(6):405-10
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  • [Title] Effect of Matrigel on adenoid cystic carcinoma cell line differentiation.
  • Adenoid cystic carcinoma (ACC) is a frequent malignant salivary gland neoplasm presenting different growth patterns described as tubular, cribriform and solid, which represent distinct differentiation stages.
  • [MeSH-major] Biocompatible Materials / pharmacology. Carcinoma, Adenoid Cystic / pathology. Collagen / pharmacology. Laminin / pharmacology. Proteoglycans / pharmacology. Salivary Gland Neoplasms / pathology

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  • [ISSN] 0959-9673
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Drug Combinations; 0 / Laminin; 0 / Proteoglycans; 119978-18-6 / matrigel; 9007-34-5 / Collagen
  • [Number-of-references] 14
  • [Other-IDs] NLM/ PMC2517392
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99. do Nascimento KC, de Faria PR, Dib LL, Ferreira de Aguiar MC, Cardoso SV, Chen J, Loyola AM: Immunohistochemical localization of the NM23 protein in salivary gland neoplasms with distinct biological behavior. Virchows Arch; 2006 Dec;449(6):660-6
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  • [Title] Immunohistochemical localization of the NM23 protein in salivary gland neoplasms with distinct biological behavior.
  • However, its association with the metastatic phenotype of salivary gland neoplasms (SGN) remains unknown.
  • To evaluate the role of NM23 in SGN, the expression patterns of NM23 in the following were compared: benign (pleomorphic adenoma) vs malignant (adenoid cystic carcinoma and mucoepidermoid carcinoma) SGN, and primary malignancies with/without evidence of metastasis vs their metastatic implants (MI).
  • [MeSH-major] Nucleoside-Diphosphate Kinase / analysis. Salivary Gland Neoplasms / chemistry

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  • (PMID = 17091257.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / NM23 Nucleoside Diphosphate Kinases; EC 2.7.4.6 / NME1 protein, human; EC 2.7.4.6 / Nucleoside-Diphosphate Kinase
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100. Luo SD, Su CY, Chuang HC, Huang CC, Chen CM, Chien CY: Estrogen receptor overexpression in malignant minor salivary gland tumors of the sinonasal tract. Otolaryngol Head Neck Surg; 2009 Jul;141(1):108-13
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  • [Title] Estrogen receptor overexpression in malignant minor salivary gland tumors of the sinonasal tract.
  • OBJECTIVES: To identify the expression of estrogen receptors in malignant minor salivary gland tumors of the sinonasal tract.
  • SUBJECTS AND METHODS: A retrospective review of a pathology database identified 17 patients with malignant salivary gland tumors between December 1987 and January 2006.
  • RESULTS: Among these malignant tumors, adenoid cystic carcinoma was the predominant histologic type.
  • Seventy-five percent of cases of adenoid cystic carcinoma were positive for estrogen receptor alpha.
  • In contrast, only 17 percent of cases of adenoid cystic carcinoma were positive for estrogen receptor beta.
  • CONCLUSION: Malignant minor salivary gland tumors of the sinonasal tract are rare disease entities.
  • In the present series, adenoid cystic carcinoma was the most common form of tumor, but the prognosis was poor.
  • Most of the cases were positive for expression of estrogen receptor alpha, which suggests that hormone therapy may have a role in the management of certain minor salivary gland tumors of the paranasal sinus and nasal cavity.
  • [MeSH-major] Paranasal Sinus Neoplasms / metabolism. Receptors, Estrogen / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 19559968.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen
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