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6. Liukko T, Mäkitie AA, Markkola A, Ylikoski J, Bäck L: Radiofrequency induced thermotherapy: an alternative palliative treatment modality in head and neck cancer. Eur Arch Otorhinolaryngol; 2006 Jun;263(6):532-6
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  • Five patients had pharyngeal carcinomas, one had an unknown primary tumour growing through the skin on the neck, two had a recurrent malignant melanoma originating from the maxillary sinuses, one had a carcinoma of the tongue, two had laryngeal carcinomas, and one had a recurrent adenoid cystic carcinoma of the parotid gland.

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  • (PMID = 16565858.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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7. Sharma K, Rathi AK, Khurana N, Mukherji A, Kumar V, Singh K, Bahadur AK: A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi. Indian J Cancer; 2010 Oct-Dec;47(4):424-9
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  • [Title] A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi.
  • CONTEXT: Adenoid cystic carcinoma (ACC) is a rare neoplasm that usually arises from the salivary, lacrimal, or other exocrine glands.
  • AIM: To analyze the presentation and natural history of cases of adenoid cystic tumors of salivary glands in our institution; and to compare with the existing literature.
  • RESULTS: There were 8 cases of major salivary gland tumors (47%), of which 2 were in the submandibular and 6 were involving the parotid.
  • Ten patients (53%) had minor salivary gland involvement.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Female. Humans. India. Male. Middle Aged. Neoplasm Staging. Oral Surgical Procedures. Radiotherapy. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 21131757.001).
  • [ISSN] 1998-4774
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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8. Kawamata T, Harashima S, Kubo O, Hori T: Intrasellar remote metastasis from adenoid cystic carcinoma of parotid gland: case report. Endocr J; 2006 Oct;53(5):659-63
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  • [Title] Intrasellar remote metastasis from adenoid cystic carcinoma of parotid gland: case report.
  • Adenoid cystic carcinoma is a tumor of exocrine glands originating primarily from the minor and major salivary glands, lacrimal gland, bronchus, breast, and intestinal and genital tracts.
  • Intracranial remote metastasis from adenoid cystic carcinoma in salivary gland is quite rare.
  • The authors encountered a case of intrasellar remote metastasis from an adenoid cystic carcinoma of parotid gland origin, presenting with hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
  • To our knowledge, this is the first reported case of metastasis from an adenoid cystic carcinoma to intrasellar area.
  • A 78-year-old woman had an adenoid cystic carcinoma in the left parotid gland, which was resected surgically followed by local radiation therapy of 60 Gy.
  • Histopathological examination of the tumor specimens revealed adenoid cystic carcinoma, which had identical histological findings as those of the painful superficial cervical lymph nodes resected in the same operation.
  • Although rare, metastasis from tumors including those of salivary gland origin should be considered in the differential diagnosis of unusual pituitary tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology. Pituitary Neoplasms / secondary. Sella Turcica

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  • (PMID = 16902261.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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9. González-García R, Nam-Cha SH, Muñoz-Guerra MF, Gamallo-Amat C: Basal cell adenoma of the parotid gland. Case report and review of the literature. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E206-9
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  • [Title] Basal cell adenoma of the parotid gland. Case report and review of the literature.
  • Its most frequent location is the parotid gland.
  • Due to prognostic implications, differential diagnosis with basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell carcinoma is mandatory.
  • We describe a case of basal cell adenoma of the parotid gland.
  • We also review the literature and discuss the diagnosis and management of this rare entity.
  • [MeSH-major] Adenoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16505803.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 21
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10. Monteiro LS, Palmeira C, Bento MJ, Lopes C: DNA content in malignant salivary gland tumours. Oral Dis; 2009 May;15(4):295-301
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  • [Title] DNA content in malignant salivary gland tumours.
  • OBJECTIVE: Our aim was to evaluate the DNA content in malignant salivary gland tumours using image cytometry and its possible relationships with clinical and morphologic findings, disease course and prognosis.
  • PATIENTS AND METHODS: The study sample comprised 31 patients diagnosed and treated for primary malignant salivary gland tumours.
  • CONCLUSION: Abnormal DNA content is a common finding in salivary gland cancers.
  • [MeSH-major] Carcinoma / genetics. DNA, Neoplasm / analysis. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Aneuploidy. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Diploidy. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Humans. Image Cytometry. Lymphatic Metastasis / genetics. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Parotid Neoplasms / genetics. Parotid Neoplasms / pathology. Polyploidy. Prognosis. Retrospective Studies. Salivary Glands, Minor / pathology. Survival Rate. Young Adult

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  • (PMID = 19320959.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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11. Semra Turki I, Miaoui A, Chammekhi R, Kchaw I, Ghorbel D, Nouira K, Menif E: [Adenoid cystic carcinoma of parotid gland: case report]. Tunis Med; 2008 Jan;86(1):92-3
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  • [Title] [Adenoid cystic carcinoma of parotid gland: case report].
  • [Transliterated title] Carcinome adénoïde kystique de la parotide.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19472715.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Tunisia
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12. Ascani G, Pieramici T, Messi M, Lupi E, Rubini C, Balercia P: Salivary glands tumours: a retrospective study of 454 patients. Minerva Stomatol; 2006 Apr;55(4):209-14
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  • RESULTS: Our results show that 63.22% of salivary glands tumors occur in the parotid gland, with a predominance of benign tumours, pleomorphic adenoma being the most prevalent histological type.
  • CONCLUSIONS: Malignant tumors were more common in the elderly than in young patients and the most common histological types were mucoepidermoid carcinoma and adenoid cystic carcinoma.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology

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  • (PMID = 16618995.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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13. Younes MN, Park YW, Yazici YD, Gu M, Santillan AA, Nong X, Kim S, Jasser SA, El-Naggar AK, Myers JN: Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. Mol Cancer Ther; 2006 Nov;5(11):2696-705
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  • [Title] Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model.
  • We hypothesized that epidermal growth factor (EGF) receptor (EGFR) activation and vascular endothelial growth factor (VEGF)-induced angiogenic signals are important for the progression and metastasis of human salivary adenoid cystic carcinoma (ACC).
  • To determine the in vivo antitumor effects of AEE788, nude mice with orthotopic parotid tumors were randomized to receive oral AEE788 alone, paclitaxel alone, cisplatin alone, a combination of AEE788 plus paclitaxel, a combination of AEE788 plus cisplatin, or a placebo.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Purines / therapeutic use. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Salivary Gland Neoplasms / drug therapy. Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors
  • [MeSH-minor] Animals. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Apoptosis / drug effects. Cisplatin / therapeutic use. Disease Models, Animal. Humans. Male. Mice. Mice, Nude. Neoplasm Metastasis. Oncogene Protein v-akt / antagonists & inhibitors. Oncogene Protein v-akt / metabolism. Parotid Gland / drug effects. Parotid Gland / metabolism. Parotid Gland / pathology. Phosphorylation / drug effects. Taxoids / therapeutic use


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4. Belli E, Mazzone N, Rendine G: Osteosarcoma radioinduced after adenoid cystic tumor of the parotid gland. J Craniofac Surg; 2010 Mar;21(2):387-9
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  • [Title] Osteosarcoma radioinduced after adenoid cystic tumor of the parotid gland.
  • Osteosarcoma can develop secondary to malignant transformation within a preexisting benign bone lesion, such as Paget disease, osteonecrosis, fibrous dysplasia, and chronic infection, or it can arise in previously irradiated areas.
  • This article presents the case of a 36-year-old woman who was affected by a radioinduced osteosarcoma after radiotherapy for an adenoid cystic carcinoma of the left parotid gland treated when she was 24 years old.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Osteosarcoma / etiology. Parotid Neoplasms / radiotherapy. Skull Base Neoplasms / etiology

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  • (PMID = 20186080.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Khafif A, Anavi Y, Haviv J, Fienmesser R, Calderon S, Marshak G: Adenoid cystic carcinoma of the salivary glands: a 20-year review with long-term follow-up. Ear Nose Throat J; 2005 Oct;84(10):662, 664-7
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  • [Title] Adenoid cystic carcinoma of the salivary glands: a 20-year review with long-term follow-up.
  • The behavior of adenoid cystic carcinoma (ACC) of the salivary glands has been shown to be unpredictable in terms of local and distant spread and mortality.
  • We retrospectively studied 35 operations in 34 patients who had had a pathologic diagnosis of ACC of the salivary glands and who had been treated over a 20-year period and followed for a minimum of 10 years.
  • The site of origin appeared to be an important factor in survival rates; survival among patients with tumors that had originated in the parotid gland was fairly good, while survival among those with tumors that originated in the minor salivary glands was significantly worse.
  • We recommend radical surgery with complete resection for all patients with ACC of the salivary glands and a careful assessment of the neck in patients with minor salivary gland tumors.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors

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  • (PMID = 16382750.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Gomez DR, Hoppe BS, Wolden SL, Zhung JE, Patel SG, Kraus DH, Shah JP, Ghossein RA, Lee NY: Outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: a recent experience. Int J Radiat Oncol Biol Phys; 2008 Apr 1;70(5):1365-72
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  • [Title] Outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: a recent experience.
  • PURPOSE: To analyze the recent experience of patients with adenoid cystic carcinoma treated with radiation therapy at Memorial Sloan-Kettering Cancer Center.
  • METHODS AND MATERIALS: From 1990 to 2004, a total of 59 patients with a diagnosis of primary adenoid cystic carcinoma of the head and neck received radiation therapy at our institution.
  • The subsite distribution was oral cavity, 28% (n = 17); paranasal sinuses, 22% (n = 13); parotid, 14% (n = 8); submandibular, 14% (n = 8); oropharynx, 10% (n = 6); sublingual, 3% (n = 2); nasopharynx, 3% (n = 2); and other, 5% (n = 3).
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Head and Neck Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Analysis of Variance. Disease-Free Survival. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Radiation Injuries / complications. Radiotherapy, Conformal / methods. Retrospective Studies. Treatment Outcome

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  • (PMID = 18029108.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Andreadis D, Epivatianos A, Poulopoulos A, Nomikos A, Papazoglou G, Antoniades D, Barbatis C: Detection of C-KIT (CD117) molecule in benign and malignant salivary gland tumours. Oral Oncol; 2006 Jan;42(1):57-65
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  • [Title] Detection of C-KIT (CD117) molecule in benign and malignant salivary gland tumours.
  • In the present study we analysed the expression of this molecule in salivary gland tumours.
  • Archival formalin-fixed, paraffin-embedded sections of 40 benign and 57 malignant salivary gland tumours were retrieved and retrospectively studied immunohistochemically using a polyclonal C-KIT antibody in an Envision/HRP technique.
  • In addition five samples of chronic submandibular sialadenitis, five normal minor salivary glands and parotid or submandibular gland tissue adjacent to benign tumour were also studied.
  • C-KIT expression was observed in cases of adenoid cystic, acinic cell polymorphous low grade, epithelial-myoepithelial, carcinosarcoma and basal cell adenocarcinomas, as in luminal cells of pleomorphic adenomas, in serous acinar and only in intercalated and a small number of striated ductal cells of inflammatory salivary gland tissue, whereas normal salivary lobules were generally negative except a weak positivity of intercalated cells.
  • Contrary to other reports, this study suggests that, C-KIT protein does not appear to be an exclusively specific marker for benign or malignant salivary gland neoplasms, but may be useful in differential diagnosis of adenoid cystic carcinoma from polymorphous low grade adenocarcinoma.
  • Furthermore its expression in serous acinar cells in sialadenitis and intercalated ductal cells in normal and inflammatory lesions may indicate a possible participation in pathogenesis of both neoplastic and non-neoplastic salivary gland diseases.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. Proto-Oncogene Proteins c-kit / analysis. Salivary Gland Neoplasms / chemistry

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  • (PMID = 16140564.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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18. Schmerber S, Righini Ch, Soriano E, Delalande C, Dumas G, Reyt E, Lavieille JP: [The outcome of treatments for carcinoma of the external auditory canal]. Rev Laryngol Otol Rhinol (Bord); 2005;126(3):165-70
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  • [Title] [The outcome of treatments for carcinoma of the external auditory canal].
  • OBJECTIVE: A retrospective analysis of management and survival of patients treated for temporal bone carcinoma.
  • PATIENTS AND METHODS: Thirty patients underwent treatment for carcinoma of the temporal bone.
  • Twenty-five squamous cell carcinomas, 1 melanoma, 2 basocellular carcinomas and 2 adenoid cystic carcinomas were treated.
  • CONCLUSION: Long-term prognosis of the carcinoma of the external auditory canal mainly depends on the stage and primary treatment.
  • The improved survival (65%) of patients treated de novo compared with those treated with salvage surgery (23%) suggests that early referral and aggressive primary surgical treatment with postoperative radiotherapy offer the greatest chance of cure.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Carcinoma, Basal Cell / therapy. Carcinoma, Squamous Cell / therapy. Ear Canal. Ear Neoplasms / therapy. Ear, Middle. Melanoma / therapy. Skull Neoplasms / therapy. Temporal Bone
  • [MeSH-minor] Adult. Aged. Antimetabolites, Antineoplastic / administration & dosage. Antimetabolites, Antineoplastic / therapeutic use. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Cisplatin / administration & dosage. Cisplatin / therapeutic use. Combined Modality Therapy. Female. Fluorouracil / administration & dosage. Fluorouracil / therapeutic use. Follow-Up Studies. Humans. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Parotid Gland / surgery. Petrous Bone / surgery. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 16366384.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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19. Dardick I, Daley TD, McComb RJ: Sialoblastoma in adults: distinction from adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jan;109(1):109-16
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  • [Title] Sialoblastoma in adults: distinction from adenoid cystic carcinoma.
  • No adult cases have been reported with a specific diagnosis of sialoblastoma.
  • If even focal cribriforming were present, such cases have undoubtedly been diagnosed as adenoid cystic carcinoma.
  • Each case, however, has the primitive histopathology with discrete nests of basaloid tumor cells, associated bilayered ductal structures and the fibromyxoid stroma characteristic for sialoblastoma with its resemblance to fetal salivary gland or salivary gland with arrested development.
  • Sialoblastoma, whether in a child or adult with or without a cribriform growth pattern, appears to have a more favorable prognosis than adenoid cystic carcinoma.
  • Aspects of the histological differential diagnosis of these 2 tumors are discussed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Palatal Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Facial Paralysis / etiology. Female. Humans. Male. Middle Aged. Palate, Hard / pathology. Parotid Neoplasms / complications. Parotid Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 19880331.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Zhao DM, He HW, Liu MY, He ZX: [Tumors of different histological type in unilateral salivary glands: a case report]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2010 Dec;28(6):680-1, 683
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  • Tumors of synchronous benign and malignant in unilateral salivary glands have rarely been reported.
  • A case of 21-year-old girl who was diagnosed as synchronously adenoid cystic carcinoma of the left parotid and pleomorphic adenoma of the left submandibular gland.
  • The classification, clinic pathology, diagnosis, possible mechanism were discussed based on similar literatures.
  • [MeSH-major] Adenoma, Pleomorphic. Carcinoma, Adenoid Cystic

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  • (PMID = 21365854.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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21. Negahban S, Daneshbod Y, Khademi B, Seif I: Papillary cystic acinic cell carcinoma with many psammoma bodies, so-called psammoma body-rich papillary cystic acinic cell carcinoma: report of a case with fine needle aspiration findings. Acta Cytol; 2009 Jul-Aug;53(4):440-4
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  • [Title] Papillary cystic acinic cell carcinoma with many psammoma bodies, so-called psammoma body-rich papillary cystic acinic cell carcinoma: report of a case with fine needle aspiration findings.
  • Psammoma bodies are infrequent in salivary gland aspirates.
  • We present a case of papillary cystic acinic cell carcinoma with many psammoma bodies and discuss the diagnostic pitfalls with other salivary gland tumors.
  • Physical examination demonstrated a 2 x 2-cm, nontender, rubbery mass inferior to the auricle in the left parotid area.
  • Sonography showed a 2-cm, cystic mass in the left parotid.
  • A preliminary diagnosis of papillary cystic salivary gland neoplasm was made and supeficial parotidectomy performed.
  • A diagnosis of papillary cystic acinic cell carcinoma with many psammoma bodies was made.
  • Aspiration cytology of papillary cystic acinic cell carcinoma with many psammoma bodies can be confused with more common tumors, such as cystic mixed tumor and adenoid cystic carcinoma with cannonballs, low grade mucoepidermoid carcinoma or cystic papillary carcinoma of the thyroid.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Carcinoma, Papillary / pathology. Diagnosis, Differential. Female. Humans

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  • (PMID = 19697733.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Lü BJ, Zhu J, Gao L, Xie L, Xu JY, Lai MD: [Diagnostic accuracy and pitfalls in fine needle aspiration cytology of salivary glands: a study of 113 cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):706-10
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  • OBJECTIVE: To describe the fine needle aspiration cytology (FNAC) features of various salivary gland lesions and to analyze the respective diagnostic value and pitfalls.
  • METHODS: 113 FNAC specimens of salivary gland lesions were reviewed and correlated with clinical and histopathologic findings.
  • RESULTS: The FNAC diagnostic failure (2); non-neoplastic lesions (12); benign neoplasm (82) and malignant neoplasm (17).
  • Cytologically, the distinction between cellular pleomorphic adenoma, adenoid cystic carcinoma and basal cell adenoma could be difficult due to their overlapping morphologic features.
  • The cytologic patterns of primary lymphoepithelial carcinoma of the parotid were indistinguishable from those of metastatic nasopharyngeal undifferentiated carcinoma.
  • The three inaccurately diagnosed cases of FNAC are, as follows: reactive lymphoid hyperplasia of lymph node mistaken as non-Hodgkin lymphoma, mucoepidermoid carcinoma diagnosed as "scanty atypical cells present" and primary lymphoepithelial carcinoma mistaken as benign lymphoepithelial lesion.
  • On the basis of FNAC, 97.4% (110 /113) were correctly depicted as benign (95/96; 99.0%) or malignant (15/17; 88.2%).
  • Furthermore, 90.3% (102 /113) (specificity = 91.9%; 102/111) were accurately diagnosed, including 91.7% (88/96) benign lesions (specificity = 92.6% ; 88/95) and 82.4% (14/17) malignant tumors (specificity = 87.5%; 14/16).
  • CONCLUSIONS: FNAC is reliable in distinguishing benign and malignant salivary gland lesions.
  • A specific cytologic diagnosis is often possible.
  • On the other hand, due to the pitfalls in cytologic diagnosis of certain salivary gland tumors, tissue biopsy for histologic examination may be necessary.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Carcinoma, Squamous Cell / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma / pathology. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Biopsy, Fine-Needle. Carcinoma, Adenoid Cystic / pathology. Child. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Male. Middle Aged. Parotid Neoplasms / pathology. Retrospective Studies. Submandibular Gland Neoplasms / pathology

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  • (PMID = 16536312.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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23. Bahadir O, Livaoglu M, Ural A: Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy. Indian J Plast Surg; 2008 Jul;41(2):201-5
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  • [Title] Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy.
  • Adenoid cystic carcinoma of the parotid gland is a rare and slowly growing, but highly malignant tumor.
  • Surgical resection of a malignant parotid tumor should include resection of the facial nerve when the nerve is involved in the tumor.
  • A 14 year-old female presented with complaints of painless enlargement of the right parotid gland and facial asymmetry.
  • Physical examination revealed a firm mass in the region of the parotid gland as well as right facial paralysis.
  • Biopsy obtained from the mass showed an adenoid cystic carcinoma of the parotid gland.

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  • [Cites] Am J Rhinol. 1999 Jul-Aug;13(4):311-4 [10485019.001]
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  • (PMID = 19753265.001).
  • [ISSN] 0970-0358
  • [Journal-full-title] Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • [ISO-abbreviation] Indian J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2740500
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / facial nerve reconstruction / parotid gland / radiotherapy
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24. Choi S, Sano D, Cheung M, Zhao M, Jasser SA, Ryan AJ, Mao L, Chen WT, El-Naggar AK, Myers JN: Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model. Clin Cancer Res; 2008 Aug 15;14(16):5081-9
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  • [Title] Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model.
  • PURPOSE: Adenoid cystic carcinoma (ACC) can often be controlled with surgery and postoperative adjuvant radiotherapy but is also characterized by late local recurrence and distant metastasis.
  • The in vivo antitumor activity of vandetanib was examined in nude mice bearing parotid gland ACC tumors.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Carcinoma, Adenoid Cystic / drug therapy. Parotid Neoplasms / drug therapy. Piperidines / pharmacology. Quinazolines / pharmacology

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  • [ErratumIn] Clin Cancer Res. 2009 Jan 1;15(1):416
  • (PMID = 18698025.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA016672
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; 0 / Piperidines; 0 / Quinazolines; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
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25. Du LX, Yuan JP, Guan H, Zhang WD, Liang BL: [Magnetic resonance imaging for diagnosis of parotid malignant tumors and the pathological basis]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 May;30(5):1107-10
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  • [Title] [Magnetic resonance imaging for diagnosis of parotid malignant tumors and the pathological basis].
  • OBJECTIVE: To investigate magnetic resonance imaging (MRI) features of parotid malignant tumors and study their pathological basis.
  • METHODS: Forty-seven patients with parotid malignant tumors confirmed by surgery (41 patients) or biopsy (6 patients) were enrolled in this study.
  • Each of the MRI features was analyzed retrospectively and the typical MRI findings of common parotid malignant tumors were summarized.
  • RESULTS: MRI allowed accurate diagnosis of parotid malignant tumors.
  • Four patients with low-grade mucoepidermoid carcinoma showed well-defined tumor margin and were difficult to distinguish from benign tumors.
  • Six patients with high-grade mucoepidermoid carcinoma had obscure margin of the tumor which easily underwent necrosis with liable lymph node involvement.
  • The 8 cases of adenoid cystic carcinoma was characterized by extensive invasion surrounding the parotid gland.
  • Most of 8 cases of malignant pleomorphic adenoma still showed high and heterogeneous signal on T2WI, with irregular shape and poorly defined margin.
  • The 4 cases of acinic cell carcinoma showed either regular or irregular tumor morphology, presenting with high signal intensity on T1WI and T(2)WI.
  • CONCLUSION: MRI is an important modality for the diagnosis of parotid malignant tumors.
  • Most of the common parotid malignant tumors have characteristic MRI and pathological features, which make possible their differential diagnosis.
  • [MeSH-major] Magnetic Resonance Imaging. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Female. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20501408.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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26. Adachi M, Iwai H, Yagi M, Minamino M, Omae M, Lee S, Yamashita T: [Clinical study of adenoid cystic carcinoma of the parotid gland]. Nihon Jibiinkoka Gakkai Kaiho; 2007 May;110(5):410-5
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  • [Title] [Clinical study of adenoid cystic carcinoma of the parotid gland].
  • We report results of a retrospective study of 12 cases of adenoid cystic carcinoma (ACC) in the parotid gland.
  • Local pain was often observed in ACC among other malignant parotid tumors.
  • Although fine-needle aspiration cytology (FNA) was not effective for preoperative diagnosis, frozen section diagnosis (FS) during surgery showed excellent results.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Parotid Neoplasms / therapy

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  • (PMID = 17564131.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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27. Chen AM, Garcia J, Bucci MK, Quivey JM, Eisele DW: The role of postoperative radiation therapy in carcinoma ex pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys; 2007 Jan 1;67(1):138-43
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  • [Title] The role of postoperative radiation therapy in carcinoma ex pleomorphic adenoma of the parotid gland.
  • PURPOSE: To evaluate the impact of postoperative radiation therapy on the clinical course of patients with carcinoma ex pleomorphic adenoma of the parotid gland.
  • METHODS AND MATERIALS: Between 1960 and 2004, 63 patients were treated with definitive surgery for carcinoma ex pleomorphic adenoma of the parotid gland.
  • Adenocarcinoma (29 patients), salivary duct carcinoma (16 patients), and adenoid cystic carcinoma (9 patients) were the most common malignant subtypes.
  • CONCLUSION: Surgery followed by postoperative radiation should be considered the standard of care for patients with carcinoma ex pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / radiotherapy. Parotid Neoplasms / radiotherapy
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Adult. Aged. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Adenoid Cystic / surgery. Combined Modality Therapy / methods. Female. Humans. Male. Middle Aged. Neoplasm Staging. Postoperative Period. Radiotherapy Dosage. Salivary Ducts. Salivary Gland Neoplasms / mortality. Salivary Gland Neoplasms / radiotherapy. Salivary Gland Neoplasms / surgery

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  • (PMID = 17049183.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Tadbi AA, Mehrabani D, Heydari ST: Sociodemographic and etiologic differences of malignant orofacial tumors in Iran. J Craniofac Surg; 2009 May;20(3):837-40
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  • [Title] Sociodemographic and etiologic differences of malignant orofacial tumors in Iran.
  • Oral malignant tumors are the sixth most common malignancy in the world, and there is a recent trend of rising incidence of these tumors in young patients.
  • The aim of this study was to compare demographic and etiologic data from young and old patients with orofacial malignant tumors.
  • Data were obtained by retrospective analysis of files of patients with malignant orofacial tumors, who were categorized into 2 groups: the young group (< or = 40 years old) an the older group (> 60 years old).
  • Tongue was the most common site for older group (37.5%), whereas that for the younger group was the parotid (29.3%).
  • We found that the pattern of malignant orofacial tumors in the young age group was changed, and these tumors can occur in young patients who report no tobacco or alcohol use.
  • [MeSH-minor] Adult. Age Factors. Alcohol Drinking / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Squamous Cell / epidemiology. Ethnic Groups / statistics & numerical data. Female. Humans. Incidence. Income. Iran / epidemiology. Male. Marital Status. Middle Aged. Parotid Neoplasms / epidemiology. Retrospective Studies. Risk Factors. Sex Factors. Smoking / epidemiology. Tongue Neoplasms / epidemiology

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  • (PMID = 19390456.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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29. Yu Y, Zhang R, Dai C: [The study on the en bloc resection of the external auditory canal to treat external auditory canal carcinoma in the early stage]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Apr;23(7):313-5
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  • [Title] [The study on the en bloc resection of the external auditory canal to treat external auditory canal carcinoma in the early stage].
  • To improve early diagnosis and the effective surgical management of external auditory canal carcinoma.
  • METHOD: Twelve cases of the early stage external auditory canal carcinoma were reviewed retrospectively.
  • Postoperative pathological diagnosis revealed that 6 cases with adenoid cystic carcinomas, 5 cases of squamous cell carcinomas, 1 case of cerumenal adenocarcinoma.
  • No lesion involved in parotid gland and lymphoid of parotid surface.
  • Five cases of squamous cell carcinomas, 1 case of cerumenal adenocarcinoma and 3 cases of adenoid cystic carcinomas received radiotherapy postoperatively.
  • All patients were alive free of carcinoma during the follow-up.
  • One patient had parotid fistula after surgery and recovered by pressure pocketing.
  • CONCLUSION: Timely and accurate biopsy is the key point to diagnose the early stage external auditory canal carcinoma.
  • The complete resection with safety margin of external auditory canal carcinoma can improve the effect of surgery.
  • [MeSH-major] Carcinoma / surgery. Ear Neoplasms / surgery. Ear, External / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 19670611.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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30. Carrillo JF, Vázquez R, Ramírez-Ortega MC, Cano A, Ochoa-Carrillo FJ, Oñate-Ocaña LF: Multivariate prediction of the probability of recurrence in patients with carcinoma of the parotid gland. Cancer; 2007 May 15;109(10):2043-51
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  • [Title] Multivariate prediction of the probability of recurrence in patients with carcinoma of the parotid gland.
  • BACKGROUND: Parotid gland carcinoma is an infrequent tumor, and series that report on these neoplasms are relatively scarce in the literature.
  • The objective of the current study was to identify prognostic factors in patients with parotid gland carcinoma and to develop a method for defining the probability of recurrence.
  • METHODS: Patients with parotid gland carcinoma who were treated at the authors' institution from January 1981 through December 2004 and who completed treatment constituted the study group.
  • Mucoepidermoid carcinoma was diagnosed in 34.6% of patients, adenoid cystic was diagnosed in 15.7% of patients, adenocarcinoma was diagnosed in 14.3% of patients, and acinic cell carcinoma was diagnosed in 9.4% of patients.
  • [MeSH-major] Carcinoma / therapy. Neoplasm Recurrence, Local. Parotid Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Logistic Models. Male. Middle Aged. Models, Statistical. Parotid Gland / surgery. Prognosis

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  • [Copyright] (c) 2007 American Cancer Society
  • (PMID = 17410532.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Tincani AJ, Del Negro A, Araújo PP, Akashi HK, Martins AS, Altemani AM, Barreto G: Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series. Sao Paulo Med J; 2006 Jan 5;124(1):26-30
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  • [Title] Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series.
  • CONTEXT AND OBJECTIVE: Salivary gland tumor management requires long-term follow-up because of tumor indolence and possible late recurrence and distant metastasis.
  • Adenoid cystic carcinoma (ACC) accounts for 10-15% of such tumors.
  • DESIGN AND SETTING: Retrospective study at Head and Neck Service, Universidade Estadual de Campinas.
  • Major salivary gland tumor extent was routinely assessed by preoperative ultrasonography.
  • Diagnosis, surgery type, margin type (negative/positive), postoperative radiotherapy and recurrence (presence/absence) were evaluated.
  • RESULTS: There were eleven major salivary gland tumors (52.3%), seven submandibular and four parotid.
  • Ten patients (47.7%) had minor salivary gland ACC (all in palate), while the submandibular was the most frequently affected major one.
  • CONCLUSION: Adenoid cystic carcinoma has locally aggressive behavior.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Female. Hospitals, Teaching. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies

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  • (PMID = 16612459.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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32. Jain VS, Singh KK, Sachdeva Y: A Case of Adenoid Cystic Carcinoma Parotid with Perineural Spread. Med J Armed Forces India; 2007 Jan;63(1):67-8
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  • [Title] A Case of Adenoid Cystic Carcinoma Parotid with Perineural Spread.

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  • (PMID = 27407943.001).
  • [ISSN] 0377-1237
  • [Journal-full-title] Medical journal, Armed Forces India
  • [ISO-abbreviation] Med J Armed Forces India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4921714
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Parotid / Perineural spread
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33. Giannini PJ, Shetty KV, Horan SL, Reid WD, Litchmore LL: Adenoid cystic carcinoma of the buccal vestibule: A case report and review of the literature. Oral Oncol; 2006 Nov;42(10):1029-32
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  • [Title] Adenoid cystic carcinoma of the buccal vestibule: A case report and review of the literature.
  • Minor salivary gland tumors of the buccal vestibule are relatively rare.
  • Adenoid cystic carcinoma is the fifth most common salivary gland malignancy following mucoepidermoid carcinoma, adenocarcinoma not otherwise specified (NOS), acinic cell adenocarcinoma and polymorphous low-grade adenocarcinoma (PLGA).
  • Greater than half of adenoid cystic carcinomas occur in the parotid and submandibular glands.
  • Adenoid cystic carcinoma tends to have a protracted clinical course with wide infiltration and late distant metastases.
  • We present a case of an adenoid cystic carcinoma of the buccal vestibule in a 59-year-old Caucasian female patient that she had been aware of for 15 years.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Mouth Neoplasms / pathology. Salivary Gland Neoplasms / pathology


34. Laco J, Simáková E, Svobodová J, Ryska A: Recurrent mucinous carcinoma of skin mimicking primary mucinous carcinoma of parotid gland: a diagnostic pitfall. Cesk Patol; 2009 Jul;45(3):79-82
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  • [Title] Recurrent mucinous carcinoma of skin mimicking primary mucinous carcinoma of parotid gland: a diagnostic pitfall.
  • Examination by fine needle aspiration cytology raised suspicion of mucoepidermoid or adenoid cystic carcinoma of the parotid gland and an excision was recommended.
  • The lateral parotidectomy specimen showed a poorly circumscribed gelatinous tumor measuring 15 mm in diameter within the parotid gland tissue.
  • Retrospective analysis of a skin biopsy from the same anatomic area performed 8 years prior to parotid neoplasm displayed a tumor with identical microscopic appearance and immunohistochemical profile (additionally performed) which was, however, misdiagnosed as a benign lesion.
  • The diagnosis of recurrent primary mucinous carcinoma of the skin infiltrating the parotid gland was established.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / diagnosis. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 19764163.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
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35. Jeong HS, Son YI, Baek CH: The pattern of lymphatic metastasis of malignant tumors in the periorbital area. Am J Otolaryngol; 2006 Jan-Feb;27(1):5-8
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  • [Title] The pattern of lymphatic metastasis of malignant tumors in the periorbital area.
  • BACKGROUND AND OBJECTIVES: The rarity of malignant tumors in the periorbital area makes it difficult to assess the patterns of lymphatic spread and to determine the optimal extent of treatment.
  • The objective of this study was to analyze the patterns of lymphatic metastasis in malignant tumors arising from the periorbital area according to the primary site and to assess the optimal extent of surgical treatment for these tumors.
  • MATERIALS AND METHODS: We retrospectively reviewed the medical records of 8 patients with malignant tumors in the periorbital area from January 1997 to June 2002.
  • The pathological diagnoses were 3 squamous cell carcinomas, 2 adenoid cystic carcinomas, 2 sebaceous carcinomas, and 1 basal cell carcinoma.
  • CONCLUSION: The results of this study suggest that more aggressive management of the parotid area is necessary in malignant tumors arising from the periorbital area, even in the medial half of the periorbital area.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / secondary. Carcinoma, Squamous Cell / secondary. Lymph Nodes / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Korea. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Assessment. Survival Rate

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  • (PMID = 16360815.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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36. Malhotra KP, Agrawal V, Pandey R: High grade transformation in adenoid cystic carcinoma of the parotid: report of a case with cytologic, histologic and immunohistochemical study. Head Neck Pathol; 2009 Dec;3(4):310-4
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  • [Title] High grade transformation in adenoid cystic carcinoma of the parotid: report of a case with cytologic, histologic and immunohistochemical study.
  • Adenoid cystic carcinoma (ACC) constitutes about 4% of salivary epithelial tumors and is the second common malignant epithelial salivary gland tumor involving both the major and minor salivary glands.
  • We report the first case of ACC with high grade transformation involving the parotid.
  • A 54-year-old man with a history of right parotid painful swelling from 1.5 years presented with recent increase in size of the swelling and facial paresis of 2 months duration.
  • The locally invasive salivary neoplasm was composed predominantly of an undifferentiated carcinoma with foci of conventional ACC occupying less than 10% of tumor area.
  • Recognition of occasional clusters of basaloid cells and hyaline globules in association with larger poorly differentiated malignant cell population in aspiration smears can help in cytological diagnosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology

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  • [Cites] Hum Pathol. 2001 Dec;32(12):1403-7 [11774177.001]
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  • (PMID = 20016788.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
  • [Keywords] NOTNLM ; Adenoid cystic / Carcinoma / Cytology / Ki-67 / Parotid / Pathology / p53
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37. Kara MI, Göze F, Ezirganli S, Polat S, Muderris S, Elagoz S: Neoplasms of the salivary glands in a Turkish adult population. Med Oral Patol Oral Cir Bucal; 2010 Nov;15(6):e880-5
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  • OBJECTIVE: This retrospective study aimed to investigate the types and distribution of neoplasm of salivary glands in a Turkish population.
  • STUDY DESIGN: The histological diagnosis records of the Department of Pathology at Cumhuriyet University were reevaluated for 125 patients who were treated for salivary gland tumors from 1987 to 2008.
  • The neoplasms were analyzed for histological diagnosis, age, sex, and site.
  • RESULTS: A total of 125 primary salivary gland neoplasms, consisting of 95 (76%) benign and 30 (24%) malignant groups were recorded.
  • The most common major and minor salivary gland sites were the parotid (61.6%) and palatal glands (9.6%), respectively.
  • Among the malignant group, adenoid cystic carcinoma was the most prevalent.
  • CONCLUSIONS: Although there were some discrepancies, the characteristics of salivary gland tumors of Turkish patients are in line with those of patients from other countries according to tumor type, tumor site distribution, and age and sex of patients.
  • [MeSH-major] Salivary Gland Neoplasms / pathology

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  • (PMID = 20526249.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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38. Perez DE, Magrin J, de Almeida OP, Kowalski LP: Multiple cutaneous metastases from a parotid adenoid cystic carcinoma. Pathol Oncol Res; 2007;13(2):167-9
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  • [Title] Multiple cutaneous metastases from a parotid adenoid cystic carcinoma.
  • Cutaneous metastasis from salivary gland adenoid cystic carcinoma is extremely rare.
  • We report a case of a 39-year-old man that presented multiple cutaneous metastases from a parotid salivary gland adenoid cystic carcinoma.
  • This case shows the importance of a detailed and periodical skin examination in patients treated for salivary gland adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Parotid Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 17607381.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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39. Bhattacharyya N, Fried MP: Determinants of survival in parotid gland carcinoma: a population-based study. Am J Otolaryngol; 2005 Jan-Feb;26(1):39-44
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  • [Title] Determinants of survival in parotid gland carcinoma: a population-based study.
  • PURPOSE: To determine survival and factors influencing survival for parotid gland cancer.
  • METHODS: Cases of parotid gland malignancy were extracted from the SEER database for 1988 to 1998.
  • Subset analysis was conducted for mucoepidermoid carcinoma according to grade.
  • Mean tumor size at diagnosis was 2.7 cm; 38.0% of patients had extraglandular extension of the tumor, 26.8% of patients had positive nodal disease, and 59.4% of patients received radiation therapy.
  • Tumor histology did predict survival, with squamous cell carcinoma and acinar cell carcinoma exhibiting the poorest and best survivals, respectively.
  • CONCLUSIONS: Survival in parotid gland malignancy is influenced by multiple factors.
  • [MeSH-major] Adenocarcinoma / mortality. Carcinoma, Squamous Cell / mortality. Parotid Neoplasms / mortality
  • [MeSH-minor] Age Factors. Carcinoma, Acinar Cell / mortality. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Mucoepidermoid / mortality. Female. Humans. Male. Neoplasm Staging. Prognosis. Proportional Hazards Models. Risk Factors. SEER Program. Sex Factors. Survival Analysis. United States / epidemiology

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  • (PMID = 15635580.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Guo XL, Wei FC, Sun SZ: [Clinical study of oral and maxillofacial malignancies associated with multiple primary malignant neoplasms]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2006 Feb;24(1):42-4
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  • [Title] [Clinical study of oral and maxillofacial malignancies associated with multiple primary malignant neoplasms].
  • OBJECTIVE: To study the clinical characteristics, diagnosis and treatment strategy of oral and maxillofacial malignancies in multiple primary malignant neoplasms (MPMNs).
  • RESULTS: There were 44 malignant cases in the 21 MPMNs patients.
  • Among the 44 cases, there were 24 cases in alimentary and respiratory tract such as oral, pharynx, esophagus, stomach and lung, and 10 cases in salivary gland, breast and female reproductive system.
  • There were 25 cases malignant neoplasms in oral and maxillofacial region where squamous cell carcinoma was the most common pathologic type, secondly adenoid cystic carcinoma.
  • In oral and maxillofacial region, MPMNs were often found in tongue, parotid and submandibular gland, buccal mucosa and gingival.
  • CONCLUSION: Tongue and salivary gland were the common locations with MPMNs, and they were closely associated with alimentary and respiratory tract.
  • Regular follow-up, early detection, early diagnosis, active and effective treatment can help to improve the survival quality of MPMNs patients.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Carcinoma, Squamous Cell. Mouth Neoplasms. Neoplasms, Multiple Primary

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  • (PMID = 16541654.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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41. Iseli TA, Karnell LH, Preston TW, Graham SM, Funk GF, Buatti JM, Gupta AK, Robinson RA, Hoffman HT: Facial nerve sacrifice and radiotherapy in parotid adenoid cystic carcinoma. Laryngoscope; 2008 Oct;118(10):1781-6
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  • [Title] Facial nerve sacrifice and radiotherapy in parotid adenoid cystic carcinoma.
  • OBJECTIVES: To evaluate the impact of facial nerve sacrifice and postoperative radiotherapy on the outcome of adenoid cystic carcinoma of the parotid gland.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Facial Nerve / surgery. Parotid Neoplasms / surgery

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  • (PMID = 18758382.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Das DK, Haji BE, Ahmed MS, Hossain MN: Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report. Acta Cytol; 2005 Jan-Feb;49(1):65-70
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  • [Title] Myoepithelioma of the parotid gland initially diagnosed by fine needle aspiration cytology and immunocytochemistry: a case report.
  • BACKGROUND: Myoepithelioma is a rare, benign tumor of the salivary gland, most commonly affecting the parotid gland.
  • CASE: A 33-year-old man presented with a left parotid swelling 2.5 cm in diameter and of about 5 years' duration.
  • Red to purple, myxoid matrix was present as a scanty fibrillar substance and as globules surrounded by tumor cells vaguely reminiscent of adenoid cystic carcinoma.
  • CONCLUSION: FNA cytologic features together with immunocytochemical studies on smears can offer a preoperative diagnosis of myoepithelioma.
  • [MeSH-major] Myoepithelioma / diagnosis. Myoepithelioma / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology

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  • (PMID = 15717758.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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43. Boukheris H, Curtis RE, Land CE, Dores GM: Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev; 2009 Nov;18(11):2899-906
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  • [Title] Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States.
  • Squamous cell (IR, 3.44) and mucoepidermoid (IR, 3.23) carcinomas occurred most frequently among males, whereas mucoepidermoid (IR, 2.67), acinic cell (IR, 1.57), and adenoid cystic (IR, 1.40) carcinomas were most common among females.
  • Mucoepidermoid, acinic cell, and adenoid cystic carcinomas predominated in females through age approximately 50 years; thereafter, IRs of acinic cell and adenoid cystic carcinomas were nearly equal among females and males, whereas IRs of mucoepidermoid carcinoma among males exceeded IRs among females (IRR, 1.57; 95% CI, 1.38-1.78).
  • Except for mucoepidermoid and adenoid cystic carcinomas, which occurred equally among all races, other subtypes had significantly lower incidence among Blacks and Asians/Pacific Islanders than among Whites.
  • Adenoid cystic carcinoma occurred equally in the submandibular and parotid glands, and other M-SGC histologic subtypes evaluated had 77% to 98% lower IRs in the submandibular gland.
  • [MeSH-major] Salivary Gland Neoplasms / classification. Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Prognosis. Risk Factors. SEER Program. United States / epidemiology. World Health Organization. Young Adult

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  • (PMID = 19861510.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CP010183-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS144622; NLM/ PMC2779732
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44. Lourenço SV, Lima DM: Pleomorphic adenoma and adenoid cystic carcinoma: in vitro study of the impact of TGFbeta1 on the expression of integrins and cytoskeleton markers of cell differentiation. Int J Exp Pathol; 2007 Jun;88(3):191-8
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  • [Title] Pleomorphic adenoma and adenoid cystic carcinoma: in vitro study of the impact of TGFbeta1 on the expression of integrins and cytoskeleton markers of cell differentiation.
  • Pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) are the commonest benign and malignant salivary gland tumours respectively.
  • PA cells showed increased expression of integrins and de novo expression of differentiation markers upon TGFbeta1 stimulation.
  • This may reflect important differences in the biological behaviour of benign and malignant cells.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Carcinoma, Adenoid Cystic / metabolism. Integrins / metabolism. Parotid Neoplasms / metabolism. Transforming Growth Factor beta1 / pharmacology

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  • [Cites] Genes Dev. 2000 Mar 15;14(6):627-44 [10733523.001]
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  • (PMID = 17504449.001).
  • [ISSN] 0959-9673
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Antigens, Differentiation; 0 / Integrin beta3; 0 / Integrin beta4; 0 / Integrins; 0 / Transforming Growth Factor beta1
  • [Other-IDs] NLM/ PMC2517303
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45. Sartorius C, Gille F, Bédrossian-Pfingsten J, Kempf HG: [Salivary duct carcinoma of the sublingual gland--a case report]. Laryngorhinootologie; 2006 Jul;85(7):517-9
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  • [Title] [Salivary duct carcinoma of the sublingual gland--a case report].
  • RATIONALE: Pleomorphic adenoma is the most common neoplasm of major and minor salivary gland origin, followed by infectious reasons and sialolithiasis.
  • The salivary duct carcinoma represents a rare variant of the group of adenocarcinomas originated from the salivary glands, especially extremely rare from minor salivary gland origin.
  • A biopsy showed a rare salivary duct carcinoma of comedo-type originated from the left sublingual salivary gland.
  • DISCUSSION: Salivary duct carcinoma is a rare, high-grade malignant epithelial neoplasm, which occurs almost exclusively in the parotid.
  • There is some histologic similarity to intraductal carcinoma of the breast.
  • Differential diagnosis comprises adenoid cystic carcinoma, metastases of other adenocarcinomas, such as the carcinoma of the thyroid gland and the comedocarcinoma of the breast.
  • CONCLUSION: A rare case of a salivary duct carcinoma of sublingual salivary gland origin is presented.
  • [MeSH-major] Carcinoma, Ductal. Salivary Ducts. Salivary Gland Neoplasms. Sublingual Gland
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Prognosis. Time Factors

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  • (PMID = 16586279.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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46. Kwon YD, Biesterfeld S, Hansen T, Schwerdtfeger A, Kunkel M: Lymphadenomatous carcinoma of the sublingual gland: report of a first case in an unusual localization. Head Neck; 2008 Oct;30(10):1394-8
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  • [Title] Lymphadenomatous carcinoma of the sublingual gland: report of a first case in an unusual localization.
  • BACKGROUND: Lymphadenomatous carcinoma of the salivary gland is a very rare tumor, which hitherto occurred exclusively in the parotid gland.
  • This report describes a case of lymphadenomatous carcinoma of the sublingual gland, which is thought to be the first report of this special entity.
  • CONCLUSION: The clinical behavior, the age of the patient, and the sublingual localization differentiate this lesion from the sebaceous type, favoring lymphadenomatous carcinoma as a distinct clinical entity.
  • [MeSH-major] Adenolymphoma / pathology. Carcinoma, Adenoid Cystic / pathology. Sublingual Gland Neoplasms / pathology

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  • [Copyright] Copyright (c) 2008 Wiley Periodicals, Inc. Head Neck 2008.
  • (PMID = 18327777.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Maiuri F, Gangemi M, Giamundo A, Mariniello G, Colella A, Vergara P, Del Basso De Caro ML: Intracranial extension of salivary gland tumors. Clin Neuropathol; 2010 Jan-Feb;29(1):9-13
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  • [Title] Intracranial extension of salivary gland tumors.
  • OBJECTIVE: The aim of this report is to describe 3 cases of salivary gland tumors with intracranial extension associated to an extracerebral mass lesion, and to discuss the frequence, pathology and treatment of these very rare localizations.
  • The primary tumors were an adenocarcinoma and a malignant oncocytoma of the parotid gland and an adenoid cystic carcinoma of the submandibular gland.
  • CONCLUSIONS: The intracranial extension of salivary gland tumors is a very rare event.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Brain Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 20040327.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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48. Maruya S, Namba A, Matsubara A, Kakehata S, Takeda I, Shirasaki T, Hatayama Y, Nagahata M, Yokoyama J, Shinkawa H: Salivary gland carcinoma treated with concomitant chemoradiation with intraarterial cisplatin and docetaxel. Int J Clin Oncol; 2006 Oct;11(5):403-6
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  • [Title] Salivary gland carcinoma treated with concomitant chemoradiation with intraarterial cisplatin and docetaxel.
  • Malignant neoplasms of the salivary gland are uncommon entities in which surgical resection of the primary lesion has been accepted as a standard therapeutic option.
  • We treated one patient with recurrent adenoid cystic carcinoma arising from the sublingual gland and one patient with primary adenocarcinoma arising from the parotid gland with transfemoral intraarterial chemotherapy, based on full-dose cisplatin and docetaxel and concurrent external-beam radiotherapy.
  • The concomitant chemoradiotherapy of cisplatin and docetaxel seemed to be a practicable option for patients with recurrent and unresectable salivary gland carcinomas.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Parotid Neoplasms / drug therapy. Parotid Neoplasms / radiotherapy. Sublingual Gland Neoplasms / drug therapy. Sublingual Gland Neoplasms / radiotherapy
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Aged. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / radiotherapy. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Humans. Infusions, Intra-Arterial. Male. Middle Aged. Radiotherapy, Adjuvant. Taxoids / administration & dosage. Treatment Outcome

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  • (PMID = 17058139.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; Q20Q21Q62J / Cisplatin
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49. Guzzo M, Ferrari A, Marcon I, Collini P, Gandola L, Pizzi N, Casanova M, Mattavelli F, Scaramellini G: Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan. Pediatr Blood Cancer; 2006 Nov;47(6):806-10
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  • [Title] Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan.
  • BACKGROUND: Epithelial salivary gland tumors are very uncommon in pediatric age.
  • RESULTS: The major salivary glands were the main site of tumor occurrence (79% of cases arose in parotid glands); 37 patients had benign tumors (pleomorphic adenoma), 15 had malignant tumors (12 mucoepidermoid carcinoma, 9 low grade).
  • All the patients were treated by surgery; local relapses after parotidectomy were 4% and 25%, in benign and malignant tumors, respectively.
  • At the time of the report, all patients with benign tumors were alive, 35(95%) without evidence of disease; only one patient with malignant tumor died of disease.
  • Parotidectomy (total or superficial) is the best choice for achieving good cure rates in both benign and malignant tumors.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Carcinoma, Acinar Cell / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / surgery. Neoplasm Recurrence, Local / surgery. Salivary Gland Neoplasms / surgery

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16425245.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Oudidi A, El-Alami MN, Boulaich M, Jazouli N, Kzadri M: [Primary sub-mandibular gland tumours: experience based on 68 cases]. Rev Laryngol Otol Rhinol (Bord); 2006;127(3):187-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary sub-mandibular gland tumours: experience based on 68 cases].
  • [Transliterated title] Les tumeurs primitives de la glande sous-maxillaire: à propos de 68 cas.
  • Sub-mandibulary gland tumours are less common than tumours of the parotid and pose many clinical and therapeutic challengers.
  • PATIENTS AND METHODS: Retrospective studies of sub-mandibular gland tumours presenting to our department between 1986 and 2000.
  • RESULTS: 68 cases were reviewed comprising 37 benign and 31 malignant tumours (15 females and 33 males).
  • Definitive diagnosis was by complete excision and pathological examination.
  • For malignant lesions (n= 31) the most frequent were: Adenoid cystic carcinoma (n= 10), epidermoid carcinoma (n= 5), adenocarcinoma (n= 5), mucoepidermoid carcinoma (n= 3), malignant non Hodgkinien lymphoma (n= 5).
  • Treatment was by total surgical excision of the submandibular gland for the begnin tumours.
  • For the malignant lesions it was associated acording to their extension with other anatomical region or in case of adenopathy with neck dissection.
  • CONCLUSION: Malignity in sub-mandibular gland tumours is more frequent than in the parotid gland.
  • Any delay in diagnosis or inappropriate management may result in a poor prognosis for the patient.
  • [MeSH-major] Submandibular Gland Neoplasms / classification. Submandibular Gland Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Early Diagnosis. Female. Humans. Male. Middle Aged. Prognosis

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  • (PMID = 17007195.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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51. Ayadi K, Ayadi L, Daoud E, Mnif Z, Ben Mahfoudh K, Boudawara T, Mnif J: Adenoid cystic carcinoma of the parotid with facial nerve invasion. Tunis Med; 2010 Jan;88(1):46-8
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  • [Title] Adenoid cystic carcinoma of the parotid with facial nerve invasion.
  • BACKGROUND: Adenoid cystic carcinoma comprises approximately 10% of all epithelial salivary neoplasms and most frequently involves the parotid.
  • AIM: The authors report a case of parotid adenoid cystic carcinoma with invasion and spread via the facial nerve with an emphasis on radiologic features.
  • The magnetic resonance imaging (MRI) examination showed a right parotid gland solid mass located in the deep lobe of the parotid gland with mastoid bony involvement.The mass was heterogenously enhanced.
  • Pathologic examination of the resected specimen revealed histological features of adenoid cystic carcinoma with intra neural invasion of the mastoid segment of the facial nerve.
  • CONCLUSION: This study confirms that multiplanar approach of MRI allows rapid detection of adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Facial Nerve / pathology. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20415214.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Tunisia
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52. Chakrabarti S, Bera M, Bhattacharya PK, Chakrabarty D, Manna AK, Pathak S, Maiti K: Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry. J Indian Med Assoc; 2010 Dec;108(12):833-6
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  • [Title] Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry.
  • Salivary gland swelling is a common and important problem.
  • Acute and chronic sialadenitis, different benign and malignant neoplasms are the common causes which present with salivary gland swelling.
  • Imaging technique is not so helpful in pre-operative diagnosis; microscopical examination is required for diagnosis.
  • The study was done with 40 cases of salivary gland swelling.
  • Out of 40 cases, 25 involved the parotid gland, most common age group affected was 20 - 40 years and male: female ratio was 5: 3.
  • Among these 3 cases, 2 were adenoid cystic carcinoma which was cytologically diagnosed as benign neoplasm (monomorphic adenoma).
  • This study corroborates well with other studies including immunohistochemical findings. p53 expression was found to be related with nature of the neoplasm.
  • FNAC is an important tool for early diagnosis of salivary gland lesions.
  • [MeSH-major] Biopsy, Fine-Needle. Salivary Gland Diseases / pathology

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  • (PMID = 21661459.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] India
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53. Park YW, Kim SG, Choi JY, Lee SK: Recapitulating orthotopic tumor model through establishment of a parotid gland tumor with lung metastasis using HeLa cell injection into nude mice. Oncol Rep; 2010 Mar;23(3):701-8
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  • [Title] Recapitulating orthotopic tumor model through establishment of a parotid gland tumor with lung metastasis using HeLa cell injection into nude mice.
  • The object of this study was to determine the effect of recipient bed of tumor xenograft on tumor metastasis using a novel parotid gland tumor model.
  • HeLa cells were xenografted into the parotid gland or subcutaneous tissues of athymic mice.
  • Immunohistochemical staining was done for the vascular metastasis-related factors on 26 human salivary gland tumors.
  • HeLa cells showed significantly higher lung metastatic potential in the parotid gland than in the subcutis.
  • Immunohistochemical staining revealed overexpression of FGF-2 in the parotid tumors compared to the subcutaneous tumors.
  • In conclusion, a parotid tumor model of HeLa cells was successfully developed and it closely mimics high metastasis.
  • [MeSH-major] Lung Neoplasms / secondary. Parotid Neoplasms / pathology
  • [MeSH-minor] Animals. Carcinoma, Adenoid Cystic / blood supply. Carcinoma, Adenoid Cystic / pathology. Epidermal Growth Factor / pharmacology. Fibroblast Growth Factor 2 / analysis. HeLa Cells. Humans. Male. Mice. Mice, Nude. Neoplasm Transplantation. Receptor, Epidermal Growth Factor / metabolism. Transplantation, Heterologous. Xenograft Model Antitumor Assays

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  • (PMID = 20127009.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 103107-01-3 / Fibroblast Growth Factor 2; 62229-50-9 / Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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54. Shi J, Wang S, Zhao E, Shi L, Xu X, Fang M: Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma. J Oral Pathol Med; 2010 Aug 1;39(7):548-51
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  • [Title] Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma.
  • AIMS: To investigate the relationship between paxillin expression and clinicopathological features and metastasis in salivary adenoid cystic carcinoma (SACC).
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Paxillin / analysis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Coloring Agents. Cytoplasm / ultrastructure. Extracellular Space. Female. Histocytochemistry. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Parotid Neoplasms / pathology. Salivary Glands, Minor / pathology. Submandibular Gland Neoplasms / pathology. Young Adult

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  • (PMID = 20136697.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / PXN protein, human; 0 / Paxillin
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55. Ito FA, Ito K, Vargas PA, de Almeida OP, Lopes MA: Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. Int J Oral Maxillofac Surg; 2005 Jul;34(5):533-6
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  • [Title] Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases.
  • Salivary gland tumors are uncommon and the microscopical features can be complex.
  • Out of all cases, 335 (67.5%) were classified as benign and 161 (32.5%) as malignant.
  • The majority of the cases occurred in the parotid gland (67.7%), followed by the minor salivary glands (22.8%) and submandibular gland (9.5%).
  • Among the minor salivary gland tumors, the palate was the most frequent location (67%).
  • Pleomorphic adenoma was the most frequent tumor representing 54.2% of all cases, followed by mucoepidermoid carcinoma (13.5%), Warthin's tumor (8.5%) and adenoid cystic carcinoma (7.9%).
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Brazil / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. Female. Humans. Male. Middle Aged. Neoplasms, Glandular and Epithelial / epidemiology. Palate / pathology. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Sex Factors. Submandibular Gland Neoplasms / epidemiology

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  • (PMID = 16053874.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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56. Gierek T, Majzel K, Jura-Szołtys E, Slaska-Kaspera A, Witkowska M, Klimczak-Gołab L: [A 20-year retrospective histoclinical analysis of parotid gland tumors in the ENT Department AM in Katowice]. Otolaryngol Pol; 2007;61(4):399-403
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  • [Title] [A 20-year retrospective histoclinical analysis of parotid gland tumors in the ENT Department AM in Katowice].
  • INTRODUCTION: Salivary gland neoplasms represent the diverse group of tumours encountered by the head and neck surgeons.
  • MATERIAL AND METHODS: The study is analysis of 531 patients with parotid gland tumours in patients treated in ENT Department during 1986-2006.
  • The results of histological diagnosis were presented.
  • RESULTS: The frequency of incidence of benign neoplasm was 80%.
  • Malignant tumours constituted 20% of all gland tumours.
  • Mucoepidermoid (27%) and adenoid cyst (22%) carcinomas were the most common malignant tumour.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Parotid Neoplasms / epidemiology
  • [MeSH-minor] Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Mucoepidermoid / pathology. Carcinoma, Mucoepidermoid / surgery. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Retrospective Studies

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  • (PMID = 18260221.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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57. Lee MW, Batoroev YK, Odashiro AN, Nguyen GK: Solitary metastatic cancer to the thyroid: a report of five cases with fine-needle aspiration cytology. Cytojournal; 2007;4:5
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  • Four patients were known to have a solid cancer treated by radical surgery 1 to 4 years prior [1 bronchogenic squamous cell carcinoma, 1 parotid adenoid cystic carcinoma, 1 renal cell carcinoma (RCC) and 1 cutaneous melanoma], and 1 patient had no past history of cancer.

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  • (PMID = 17263878.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1808473
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58. Lee TK, Rosen II, Gibbons JP, Fields RS, Hogstrom KR: Helical tomotherapy for parotid gland tumors. Int J Radiat Oncol Biol Phys; 2008 Mar 1;70(3):883-91
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  • [Title] Helical tomotherapy for parotid gland tumors.
  • PURPOSE: To investigate helical tomotherapy (HT) intensity-modulated radiotherapy (IMRT) as a postoperative treatment for parotid gland tumors.
  • Helical tomotherapy is an effective alternative to SMLC IMRT for treatment of parotid tumors.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Parotid Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated / methods
  • [MeSH-minor] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / radiography. Carcinoma, Adenoid Cystic / radiotherapy. Humans. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted / methods. Tomography, Spiral Computed. Tumor Burden

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  • (PMID = 18164857.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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59. Dahse R, Kosmehl H: Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma. Br J Cancer; 2008 Jul 8;99(1):90-2
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  • [Title] Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma.
  • Activating mutations within the epidermal growth factor receptor (EGFR) identify lung adenocarcinoma patients with improved clinical responses to tyrosine kinase inhibitors gefitinib and erlotinib.
  • By screening salivary gland carcinoma, two drug-sensitizing EGFR exon 19 delE746-A750 mutations were identified in an adenocystic and in a mucoepidermoid carcinoma of the parotid gland.
  • [MeSH-major] Drug Resistance / genetics. Parotid Neoplasms / drug therapy. Parotid Neoplasms / genetics. Protein Kinase Inhibitors / therapeutic use. Receptor, Epidermal Growth Factor / genetics
  • [MeSH-minor] Aged. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Mucoepidermoid / drug therapy. Carcinoma, Mucoepidermoid / genetics. DNA, Neoplasm / genetics. Erlotinib Hydrochloride. Exons. Female. Humans. Male. Middle Aged. Mutation. Quinazolines / therapeutic use

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  • (PMID = 18542074.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib
  • [Other-IDs] NLM/ PMC2453031
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60. Ishibashi M, Fujii S, Kawamoto K, Nishihara K, Matsusue E, Kodani K, Kaminou T, Ogawa T: Capsule of parotid gland tumor: evaluation by 3.0 T magnetic resonance imaging using surface coils. Acta Radiol; 2010 Dec;51(10):1103-10
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  • [Title] Capsule of parotid gland tumor: evaluation by 3.0 T magnetic resonance imaging using surface coils.
  • BACKGROUND: magnetic resonance (MR) imaging of parotid gland tumors has been widely reported, although few reports have evaluated the capsule of parotid gland tumors in detail.
  • PURPOSE: to evaluate the diagnostic usefulness of 3.0 T MR imaging with surface coils for detection of the parotid gland tumor capsule, and to clarify the characteristics of the capsules.
  • MATERIAL AND METHODS: seventy-eight patients with parotid gland tumors (63 benign and 15 malignant) were evaluated.
  • It was retrospectively assessed whether each parotid gland tumor was completely surrounded by a capsule.
  • Visual interpretations were compared with histopathological findings to evaluate the diagnostic ability of MR imaging to detect parotid gland tumor capsules.
  • Statistical evaluation was conducted concerning the presence of capsules, capsular irregularity, and the difference in contrast enhancement between benign and malignant tumors, and that between pleomorphic adenomas and Warthin's tumors.
  • Benign tumors had a capsule completely surrounding the tumor significantly more often than malignant tumors (P = 0.009).
  • Concerning capsular irregularity, malignant tumors tended to have more irregular capsules than benign tumors, although there were no significant differences.
  • The capsules of malignant tumors enhanced significantly more strongly than those of benign tumors (P = 0.018).
  • CONCLUSION: 3.0 T MR imaging using surface coils could correctly depict parotid gland tumor capsules in most cases.
  • Most benign and some malignant tumors had capsules completely surrounding the tumors.
  • [MeSH-major] Adenolymphoma / diagnosis. Adenoma, Pleomorphic / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Magnetic Resonance Imaging / methods. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Female. Gadolinium. Heterocyclic Compounds. Humans. Image Enhancement / methods. Male. Middle Aged. Observer Variation. Organometallic Compounds. Parotid Gland / pathology. Reproducibility of Results. Sensitivity and Specificity. Young Adult

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  • (PMID = 20883183.001).
  • [ISSN] 1600-0455
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Heterocyclic Compounds; 0 / Organometallic Compounds; 0199MV609F / gadoteridol; AU0V1LM3JT / Gadolinium
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61. Manganaris A, Kiziridou A, Manganaris T: Unusual localization of an adenoid cystic carcinoma subsequent to superficial parotidectomy for a benign lesion. J Craniofac Surg; 2007 Jan;18(1):231-5
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  • [Title] Unusual localization of an adenoid cystic carcinoma subsequent to superficial parotidectomy for a benign lesion.
  • Adenoid cystic carcinoma of the parotid gland is relatively rare.
  • According to a retrospective study of the medical records and histopathology files of 514 cases of parotid tumors operated at our hospital over a period of 18 years, adenoid cystic carcinoma represented only 2.3% of all parotid gland neoplasms, a total of 12 cases.
  • In our records we retrieved only one documented case of adenoid cystic carcinoma that originated in the parotid gland subsequent to superficial parotidectomy for a benign lesion (pleomorphic adenoma).
  • An even more exceptional presentation of adenoid cystic carcinoma is as a bilobed tumor extending from the post auricular to the temporal and zygomatic region.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17251870.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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62. Lima RA, Tavares MR, Dias FL, Kligerman J, Nascimento MF, Barbosa MM, Cernea CR, Soares JR, Santos IC, Salviano S: Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg; 2005 Nov;133(5):702-8
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  • [Title] Clinical prognostic factors in malignant parotid gland tumors.
  • OBJECTIVE: To analyze the factors in parotid malignant epithelial tumors influencing recurrences and disease-specific survival.
  • RESULTS: Forty patients had mucoepidermoid carcinoma, 18 patients adenocarcinoma NOS, 18 patients acinic cell carcinoma, 15 patients adenoid cystic carcinoma, 11 patients malignant mixed tumor, 11 patients salivary duct carcinoma, and 13 patients other pathology.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / therapy. Neoplasm Invasiveness / pathology. Parotid Neoplasms / mortality. Parotid Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. Cohort Studies. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Multivariate Analysis. Neck Dissection / methods. Neoplasm Staging. Parotid Gland / radiation effects. Parotid Gland / surgery. Probability. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Risk Assessment. Sex Factors. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 16274796.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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63. Moatemri R, Belajouza H, Farroukh U, Ommezzine M, Slama A, Ayachi S, Khochtali H, Bakir A: [Epidemiological profile of salivary-glands tumors in a Tunisian teaching hospital]. Rev Stomatol Chir Maxillofac; 2008 Jun;109(3):148-52
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  • Sixty percent of the tumors were parotid lesions, 16% were submandibular and 24% located on minor salivary glands.
  • Eighty-four percent of parotid tumors were benign.
  • Malignant-parotid tumors often affected men over 60 years of age.
  • DISCUSSION: Benign salivary-glands tumors, often have a parotid localization affect, more women in the Tunisian population.
  • Contrary to the literature, in our series, malignant tumors were predominant in women.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. Child, Preschool. Epidemiologic Studies. Female. Hospitals, Teaching / statistics & numerical data. Humans. Infant. Male. Middle Aged. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Sex Factors. Submandibular Gland Neoplasms / epidemiology. Tunisia / epidemiology

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  • (PMID = 18538362.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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64. Patel KJ, Pambuccian SE, Ondrey FG, Adams GL, Gaffney PM: Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma. Oral Oncol; 2006 Nov;42(10):994-1004
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  • [Title] Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma.
  • Adenoid cystic carcinoma (ACC) is an uncommon salivary gland malignancy characterized by indolent yet relentless growth that exhibits inherent resistance to systemic chemotherapy, surgical salvage and conventional radiotherapy.
  • Eight ACC patient specimens were compared with normal parotid gland tissue and the ACC3 cell line.
  • Genes associated with saliva production and immune response characterized normal parotid tissues while the ACC3 cell line expressed genes primarily associated with proliferation, chromosome maintenance and the cell cycle.
  • [MeSH-major] Apoptosis / genetics. Carcinoma, Adenoid Cystic / genetics. Head and Neck Neoplasms / genetics. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adult. Cyclin D1 / metabolism. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Genes, cdc. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Oligonucleotide Array Sequence Analysis / methods. Parotid Gland / metabolism. Polymerase Chain Reaction / methods. Salivation / genetics


65. Leonetti JP, Marzo SJ, Agarwal N: Adenoid cystic carcinoma of the parotid gland with temporal bone invasion. Otol Neurotol; 2008 Jun;29(4):545-8
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  • [Title] Adenoid cystic carcinoma of the parotid gland with temporal bone invasion.
  • OBJECTIVE: To present our series of 16 patients with adenoid cystic carcinoma (ACC) of the parotid gland with temporal bone invasion.
  • PATIENTS: All patients treated at our institution between July 1988 and July 2004 with parotid gland ACC with temporal bone invasion.
  • CONCLUSION: Lateral cranial base access should be used in the extirpation of ACC of the parotid gland with temporal bone involvement.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Parotid Neoplasms / pathology. Skull Neoplasms / secondary. Temporal Bone / pathology

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  • (PMID = 18317394.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Moore MG, Deschler DG, McKenna MJ, Varvares MA, Lin DT: Management outcomes following lateral temporal bone resection for ear and temporal bone malignancies. Otolaryngol Head Neck Surg; 2007 Dec;137(6):893-8
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  • RESULTS: In this group of 35 patients, the mean age was 62.7 years, with tumor histopathologies including squamous cell carcinoma (SCC, 20), basal cell carcinoma (BCC, 7), adenoid cystic carcinoma (ACC, 7), and adenocarcinoma (1).
  • [MeSH-minor] Adenocarcinoma / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Disease-Free Survival. Ear Canal / surgery. Ear, External / surgery. Ear, Middle / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Parotid Gland / surgery. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 18036417.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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67. Scott AR, Faquin WC, Deschler DG: Parotid mass in a woman with multiple cutaneous cylindromas. Head Neck; 2010 May;32(5):684-7
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  • [Title] Parotid mass in a woman with multiple cutaneous cylindromas.
  • We present a case of a woman with scalp lesions and a parotid mass.
  • METHODS: Biopsy of a skin nodule demonstrated cylindroma, and fine-needle aspiration of the parotid mass suggested membranous basal cell adenoma, which was confirmed following superficial parotidectomy.
  • RESULTS: Eighteen cases of cylindromatosis with coexistent salivary gland membranous basal cell adenoma were reported.
  • Seventeen cases involved the parotid gland; there are 2 reports of malignant transformation.
  • CONCLUSION: FADC should be considered in anyone with coexistent dermal and salivary gland neoplasms.
  • Membranous basal cell adenoma may be mistaken for adenoid cystic carcinoma on cytologic or histologic examination.
  • Total parotidectomy with facial nerve preservation or superficial parotidectomy with close follow-up is recommended, as multifocality and malignant transformation exist.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Female. Humans. Middle Aged. Parotid Gland / pathology. Parotid Gland / surgery

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  • (PMID = 19455704.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Whitt JC, Schafer DR, Callihan MD: Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth. Head Neck Pathol; 2008 Mar;2(1):41-8
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  • [Title] Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth.
  • Salivary gland tumors usually occur as single lesions.
  • We report a case of an adult male who presented with a mucoepidermoid carcinoma involving the minor salivary glands of the palate at age 57 years, followed by an adenoid cystic carcinoma of the floor of mouth at age 63 years.
  • There are 31 acceptable cases of multiple malignant salivary gland neoplasms reported in the world literature.
  • Multiple malignant tumors of the same histologic type are more common than those of different histologic type.
  • Bilateral acinic cell adenocarcinoma was the most frequent combination of multiple salivary gland malignancy, accounting for 14 cases (10 synchronous and four metachronous).
  • All involved the parotid glands bilaterally with the exception of one case that involved parotid and submandibular gland.
  • Polymorphous low-grade adenocarcinoma accounted for three of the four cases of multiple malignant tumors involving minor salivary glands.
  • Individuals with a history of malignancy are at risk for the development of additional malignant tumors and should receive appropriate clinical follow-up.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Mouth Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Palatal Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 20614341.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807610
  • [Keywords] NOTNLM ; Metachronous neoplasms / Multiple malignant salivary gland neoplasms / Salivary gland neoplasms / Salivary gland tumors / Synchronous neoplasms
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69. Manoharan M, Gomez P, Reyes MA, Soloway MS: Metastatic adenoid cystic carcinoma to the kidney in a young woman. Urology; 2006 Dec;68(6):1343.e11-2
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  • [Title] Metastatic adenoid cystic carcinoma to the kidney in a young woman.
  • The incidence of an adenoid cystic carcinoma on major salivary glands is low, constituting only about 10% to 15% of all parotid malignancies.
  • We present the case of a 21-year-old woman with a left renal metastasis from an adenoid cystic carcinoma of the parotid gland that had been surgically treated 7 years previously.
  • During follow-up, the patient developed pulmonary nodules that were metastatic adenoid cystic carcinoma and were surgically excised.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Kidney Neoplasms / secondary. Parotid Neoplasms / pathology

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  • (PMID = 17141832.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Kazakov DV, Benkova K, Michal M, Vanecek T, Kacerovska D, Skalova A: Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. Hum Pathol; 2009 Oct;40(10):1499-503
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  • [Title] Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene.
  • We present a case of a tumor involving the parotid gland that appeared identical to cutaneous spiradenoma.
  • In addition, the lesion had a malignant component identical to basal cell adenocarcinoma.
  • This is the first report of a "dermal analogue tumor" of the salivary gland that resembled a cutaneous spiradenoma and not a cylindroma.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Parotid Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 19454360.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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71. Cederblad L, Johansson S, Enblad G, Engström M, Blomquist E: Cancer of the parotid gland; long-term follow-up. A single centre experience on recurrence and survival. Acta Oncol; 2009;48(4):549-55
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  • [Title] Cancer of the parotid gland; long-term follow-up. A single centre experience on recurrence and survival.
  • BACKGROUND: The aim of the study was to investigate the results of treatment of malignant parotid gland tumours at a single centre during a 56 year period, focusing on tumour control and survival.
  • PATIENTS AND METHODS: At Uppsala University Hospital, Sweden, 144 patients (73 male and 71 female) with parotid cancer were treated between 1948 and 2004.
  • The majority of tumour-related deaths appeared in the first 3-5 years after diagnosis.
  • Age, co-morbidity, the presence of lymph node metastases, adenoid cystic carcinoma and extent of disease were important for outcome; gender, however, was not.
  • CONCLUSIONS: Age, nodal engagement, a higher T-stage, adenoid cystic carcinoma histopathology, facial palsy and intercurrent disease worsen the outcome of patients, whereas gender does not.
  • [MeSH-major] Carcinoma / epidemiology. Carcinoma / therapy. Parotid Neoplasms / epidemiology. Parotid Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / prevention & control. Neoplasm Staging. Retrospective Studies. Risk Assessment. Risk Factors. Sweden / epidemiology. Time Factors. Young Adult

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  • (PMID = 19140053.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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72. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V: Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol; 2008 Mar-Apr;29(2):142-6
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  • Ceruminal glands are modified sweat glands of the skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
  • Subsequent biopsy and histologic examination revealed pleomorphic adenoma of the external ear canal, possibly with malignant elements.
  • Magnetic resonance imaging showed no intracranial extension or any association with the adjacent parotid gland.
  • Nonspecific presentation and difficult histologic diagnosis characterize this benign neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear, External / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18314029.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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73. Pohar S, Gay H, Rosenbaum P, Klish D, Bogart J, Sagerman R, Hsu J, Kellman R: Malignant parotid tumors: presentation, clinical/pathologic prognostic factors, and treatment outcomes. Int J Radiat Oncol Biol Phys; 2005 Jan 1;61(1):112-8
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  • [Title] Malignant parotid tumors: presentation, clinical/pathologic prognostic factors, and treatment outcomes.
  • PURPOSE: To determine the important clinical/pathologic prognostic factors and optimal treatment of malignant parotid tumors.
  • METHODS AND MATERIALS: This study was a retrospective chart review of 163 patients treated for malignant parotid tumors at two institutions.
  • [MeSH-major] Parotid Neoplasms / radiotherapy. Parotid Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Child. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy Dosage. Retrospective Studies. Statistics as Topic. Treatment Outcome

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  • (PMID = 15629601.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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74. Kobayashi K, Nakao K, Yoshida M, Ando M, Ebihara Y, Asakage T, Yamasoba T: Recurrent cancer of the parotid gland: how well does salvage surgery work for locoregional failure? ORL J Otorhinolaryngol Relat Spec; 2009;71(5):239-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent cancer of the parotid gland: how well does salvage surgery work for locoregional failure?
  • PURPOSE: Many articles have discussed the clinical features of previously untreated parotid cancer, but the clinical characteristics and treatment of recurrent parotid cancer have not yet been fully described.
  • MATERIALS: We retrospectively reviewed 20 patients with recurrent parotid cancer and analyzed the therapeutic strategies and the prognostic factors.
  • In the definitive surgery group, the presence of lymph node metastasis and high-grade malignant histopathology were associated with a poor prognosis (p < 0.01).
  • CONCLUSIONS: The results suggest that aggressive definitive surgery may be justified for the treatment of recurrent parotid cancer.
  • [MeSH-major] Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / surgery. Neoplasm Recurrence, Local / mortality. Parotid Neoplasms / mortality. Parotid Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adenoma, Oxyphilic / mortality. Adenoma, Oxyphilic / secondary. Adenoma, Oxyphilic / surgery. Adult. Aged. Aged, 80 and over. Carcinoma, Mucoepidermoid / mortality. Carcinoma, Mucoepidermoid / secondary. Carcinoma, Mucoepidermoid / surgery. Facial Paralysis / mortality. Female. Humans. Kaplan-Meier Estimate. Lymphatic Metastasis. Male. Middle Aged. Neoplasms, Glandular and Epithelial / mortality. Neoplasms, Glandular and Epithelial / secondary. Neoplasms, Glandular and Epithelial / surgery. Prognosis. Retrospective Studies. Salvage Therapy / mortality. Skull Base / surgery

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19738397.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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75. de Oliveira FA, Duarte EC, Taveira CT, Máximo AA, de Aquino EC, Alencar Rde C, Vencio EF: Salivary gland tumor: a review of 599 cases in a Brazilian population. Head Neck Pathol; 2009 Dec;3(4):271-5
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  • [Title] Salivary gland tumor: a review of 599 cases in a Brazilian population.
  • Salivary gland tumors consist of a group of heterogeneous lesions with complex clinicopathological characteristics and distinct biological behaviors.
  • Worldwide series show a contrast in the relative incidence of salivary gland tumors, with some discrepancies in clinicopathological data.
  • Parotid gland tumors were the most frequent (68.5% of cases) and patient age ranged from 1 to 88 years-old (median of 45 years old).
  • The most frequent tumors were pleomorphic adenomas (68.4%) and benign tumors were significantly more frequent in the parotid (75.9%), while malignant tumors were more frequent in the minor salivary glands (40%) (P < 0.05).
  • In conclusion, women and the parotid gland were the most affected and pleomorphic adenoma was the most frequent lesion, followed by adenoid cystic carcinoma and Warthin's tumor.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / pathology

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  • (PMID = 20596844.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 15
  • [Other-IDs] NLM/ PMC2811571
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76. Daneshbod Y, Negahban S, Khademi B, Daneshbod K: Epithelial myoepithelial carcinoma of the parotid gland with malignant ductal and myoepithelial components arising in a pleomorphic adenoma: a case report with cytologic, histologic and immunohistochemical correlation. Acta Cytol; 2007 Sep-Oct;51(5):807-13
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  • [Title] Epithelial myoepithelial carcinoma of the parotid gland with malignant ductal and myoepithelial components arising in a pleomorphic adenoma: a case report with cytologic, histologic and immunohistochemical correlation.
  • BACKGROUND: To describe the cytologic, histologic and immunohistochemical findings of a case of epithelial myoepithelial carcinoma (EMC) arising from a pleomorphic adenoma (PA) of the parotid with both malignant epithelial and myoepithelial components.
  • CASE: A 29-year-old female presented with a 1.5 x 1.5-cm, palpable mass of the left parotid of 7-8 months' duration with recent enlargement and pain.
  • The cytology was reported as salivary gland neoplasm, "suggestive of adenoid cystic carcinoma, less likely pleomorphic adenoma."
  • The final diagnosis was EMC ex PA.
  • CONCLUSION: Although previous reports mention the difficulties in diagnosing EMC and differentiation from the more common salivary gland neoplasms such as PA, we like to emphasize the cytologic confusion that results when the tumors coexist.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Myoepithelioma / pathology. Neoplasms, Second Primary / pathology. Parotid Neoplasms / pathology


77. Tilakaratne WM, Jayasooriya PR, Tennakoon TM, Saku T: Epithelial salivary tumors in Sri Lanka: a retrospective study of 713 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Jul;108(1):90-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Out of the 713 epithelial salivary tumors, 356 (49.9%) were classified as benign and 357 (50.1%) as malignant, indicating a benign-to-malignant ratio of 1:1.
  • The majority of both benign (29%) and malignant (39%) tumors occurred in the minor salivary glands.
  • Malignant tumors were slightly more common in minor salivary glands, indicating a benign-to-malignant ratio of 1:0.75.
  • Pleomorphic adenoma was the most frequent tumor, representing 38% of all tumors (274 out of 713), followed by mucoepidermoid carcinoma 21.6% (154 out of 713) and adenoid cystic carcinoma 13.5% (96 out of 713).
  • The commonest benign and malignant tumors were pleomorphic adenoma and mucoepidermoid carcinoma in both major and minor salivary glands.
  • CONCLUSION: According to the findings of this study, equal frequencies of benign and malignant tumors indicate higher occurrences of malignancies, especially in the minor salivary glands, in the Sri Lankan population.
  • [MeSH-major] Neoplasms, Glandular and Epithelial / epidemiology. Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Female. Humans. Male. Middle Aged. Palatal Neoplasms / epidemiology. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Sex Factors. Sri Lanka / epidemiology

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  • (PMID = 19403317.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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78. Qing J, Zhang Q, Wei MW, Guo ZM: [Prognostic analysis of adenoid cystic carcinoma of major salivary glands of 64 cases]. Ai Zheng; 2006 Sep;25(9):1138-43
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  • [Title] [Prognostic analysis of adenoid cystic carcinoma of major salivary glands of 64 cases].
  • BACKGROUND & OBJECTIVE: Adenoid cystic carcinoma of salivary glands is a kind of highly malignant tumor, and researches on the tumors originated from major salivary glands are rare.
  • This study was to investigate prognostic factors of adenoid cystic carcinoma of major salivary glands.
  • METHODS: Clinical records of 64 patients with adenoid cystic carcinoma of major salivary glands followed up for more than 7 years were reviewed.
  • CONCLUSION: Presence or absence of nerve invasion, histological subtype, clinical stage, and positive or negative surgical margin are the independent factors affecting the prognosis of patients with adenoid cystic carcinoma of salivary glands.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Neoplasm Staging. Parotid Neoplasms / mortality. Parotid Neoplasms / pathology. Parotid Neoplasms / therapy. Prognosis. Radiotherapy, Adjuvant. Submandibular Gland Neoplasms / mortality. Submandibular Gland Neoplasms / pathology. Submandibular Gland Neoplasms / therapy. Survival Rate


79. Yurut-Caloglu V, Caloglu M, Ozyilmaz F, Saynak M, Cosar-Alas R, Karagol H, Bayir-Angin G, Uzal C: Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature. Med Oncol; 2007;24(4):458-62
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  • [Title] Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature.
  • Adenoid cystic carcinoma is the second most common malignancy of the major and minor salivary glands after mucoepidemoid carcinoma.
  • Skeletal muscle and cutaneous metastases from adenoid cystic carcinoma of the parotid gland are extremely rare.
  • In this case, a 40-year-old man with lung and bone metastases followed by skeletal muscle and cutaneous metastases from adenoid cystic carcinoma of the right parotid gland is presented.
  • [MeSH-major] Bone Neoplasms / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis. Muscle Neoplasms / diagnosis. Parotid Neoplasms / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 17917100.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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80. Kopeć T, Wierzbicka M, Szyfter W, Bem G: [Incidence of salivary gland malignancies in 12 year time period in ENT Department Medical University in Poznan]. Otolaryngol Pol; 2010 Sep-Oct;64(5):288-95
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  • [Title] [Incidence of salivary gland malignancies in 12 year time period in ENT Department Medical University in Poznan].
  • Neoplasm of salivary gland constitutes about 3% of all tumours of head and neck.
  • This work aims at the assessment of the frequency of occurrence of malignant neoplasm in parotid gland and submandibular gland based on the material collected at the ENT Department of the Medical University in Poznan in the years 1995-2006.
  • In the 12-year period, 103 patients suffered from malignant neoplasm.
  • 82 tumours were diagnosed in paroid gland and respectively 21 - in submandibular gland.
  • No neoplasm was identified in sublingual gland.
  • It was concluded, that trends in occurrence of neoplasm of salivary glands, assessed on the basis of the number of patients operated in the years 1995-2006 show that the number of malignant neoplasm cases remains on the same level.
  • The analysis of the epidemiological differences based on the comparison of the groups of patients treated for salivary gland neoplasm in the years 1995-2000 and 2001-2006 has shown that with regard to malignant neoplasm such parameters as sex, age, duration of symptoms, diameter of the tumour and level of advancement have not differed much from each other in the analyzed periods.
  • Epidemiological differences were identified in respective histological structures in the two periods analyzed: adenoid cystic carcinoma was in fact more frequent in the years 1995-2000 than in the years 2001-2006 (58.8% versus 24.1%).
  • Facial nerve paralysis was statistically more frequent in highly malignant tumours than in comparison to tumours malignant only to a slight extent.
  • [MeSH-major] Parotid Neoplasms / epidemiology. Parotid Neoplasms / pathology. Submandibular Gland Neoplasms / epidemiology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Academic Medical Centers. Adolescent. Adult. Age Distribution. Aged. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Retrospective Studies. Risk Factors. Young Adult

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  • (PMID = 21166138.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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81. Al-Khateeb TH, Ababneh KT: Salivary tumors in north Jordanians: a descriptive study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 May;103(5):e53-9
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  • STUDY DESIGN: The records of the Department of Pathology at Jordan University of Science and Technology were reviewed for patients who were treated for salivary gland tumors from 1991 to 2002.
  • RESULTS: One hundred two true neoplasms (70% benign and 30% malignant) were found.
  • The most frequent benign and malignant neoplasms found were pleomorphic adenoma (54%) and adenoid cystic carcinoma (13%), respectively.
  • The most common major and minor salivary gland sites were the parotid (51%) and palatal glands (20%), respectively.
  • Although most of major gland tumors were adenomas, carcinomas of the minor glands were only slightly less frequent than adenomas.
  • The most frequent malignant parotid tumors were adenoid cystic carcinoma and mucoepidermoid carcinoma.
  • The most frequent minor salivary gland malignant tumors were palatal adenoid cystic carcinoma.
  • CONCLUSION: North Jordanians with salivary gland tumors were found to have similar characteristics with patients of other countries with regard to tumor type, tumor site distribution, and age and sex of patients.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 17368055.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Aird DW, Puttasiddaiah P, Berry S, Spyridakou C, Kumar M: Spatial orientation of the facial nerve in relation to parotid tumours. J Laryngol Otol; 2006 May;120(5):371-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spatial orientation of the facial nerve in relation to parotid tumours.
  • OBJECTIVE: The aim of this study was to identify the distribution of parotid tumours within the gland in relation to the facial nerve branches.
  • The majority of these were located in the body and not in the tail of the parotid gland.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Facial Nerve / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Facial Paralysis / etiology. Facial Paralysis / pathology. Female. Follow-Up Studies. Hodgkin Disease / pathology. Hodgkin Disease / surgery. Humans. Male. Middle Aged. Prospective Studies

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  • (PMID = 16696874.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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83. Shang J, Sheng L, Wang K, Shui Y, Wei Q: Expression of neural cell adhesion molecule in salivary adenoid cystic carcinoma and its correlation with perineural invasion. Oncol Rep; 2007 Dec;18(6):1413-6
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  • [Title] Expression of neural cell adhesion molecule in salivary adenoid cystic carcinoma and its correlation with perineural invasion.
  • The expression of neural cell adhesion molecule (NCAM) was analyzed in immunohistochemical preparations from adenoid cystic carcinoma.
  • The goal was to evaluate whether NCAM expression could be used as a biological marker for the perineural invasion of adenoid cystic carcinoma in the head and neck.
  • A high incidence of perineural invasion was found in adenoid cystic carcinoma in the parotid, hard palate, maxillary sinus and oral cavity.
  • All 6 cases displayed positive NCAM staining, and 5 displayed perineural invasion in the primary adenoid cystic carcinoma.
  • In conclusion, NCAM expression can, to a certain extent, be used as a predictor of perineural invasion in adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Gene Expression Regulation, Neoplastic. Neural Cell Adhesion Molecules / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Humans. Immunohistochemistry. Lymph Node Excision. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 17982624.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Neural Cell Adhesion Molecules
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84. Ide F, Mishima K, Yamada H, Saito I: Adenoid cystic carcinoma ex pleomorphic adenoma of the parotid gland. Head Neck Pathol; 2009 Jun;3(2):159-62
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  • [Title] Adenoid cystic carcinoma ex pleomorphic adenoma of the parotid gland.
  • There is a considerable variation in the histologic subtype of epithelial malignancies among carcinoma ex pleomorphic adenomas (CXPA) and virtually any known carcinoma entity can develop.
  • To our knowledge, adenoid cystic carcinoma (AdCC) ex PA is quite rare despite the fact that de novo AdCC is the fourth most common salivary gland malignancy.
  • We describe a new case of AdCC ex PA in the parotid gland of a 62 year-old woman.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasms, Multiple Primary / pathology. Tomography, X-Ray Computed

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  • (PMID = 19644550.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Carcinoma ex pleomorphic adenoma / High-grade malignancy / Parotid gland
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85. Visa L, Caballero M, Grau JJ: [Response to metronomic chemotherapy in a metastatic adenoid cystic carcinoma of the parotid gland]. Acta Otorrinolaringol Esp; 2010 Nov-Dec;61(6):452-4
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  • [Title] [Response to metronomic chemotherapy in a metastatic adenoid cystic carcinoma of the parotid gland].
  • [Transliterated title] Respuesta a quimioterapia metronómica en un carcinoma adenoide quístico metastásico de parótida.
  • Formerly, salivary gland cancer was considered to be chemoresistant.
  • Data on chemotherapy treatment for adenoid cystic carcinoma consist of phase II trials.
  • Our case report shows for first time the clinical activity of low-dose paclitaxel and cisplatin chemotherapy given separately as a single agent in metastatic adenoid cystic carcinoma of the parotid.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / secondary. Cisplatin / administration & dosage. Paclitaxel / administration & dosage. Parotid Neoplasms / drug therapy. Parotid Neoplasms / pathology

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  • [Copyright] Copyright © 2009 Elsevier España, S.L. All rights reserved.
  • (PMID = 20152955.001).
  • [ISSN] 1988-3013
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antineoplastic Agents; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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91. Selcuk A, Dere H, Bahar S, Sarikaya Y, Ozcan M: Adenoid cystic carcinoma of the parotid gland presenting as temporal bone neoplasm: a case report. B-ENT; 2007;3(3):153-6
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  • [Title] Adenoid cystic carcinoma of the parotid gland presenting as temporal bone neoplasm: a case report.
  • PROBLEM: Temporal bone tumours are rare head and neck cancers that may involve both the parotid and the neck.
  • In cases with concomitant temporal bone and parotid tissue involvement, tumour origin determination can be challenging.
  • A tumour with parotid and temporal bone involvement is usually of temporal origin.
  • The tumour may also be a rare parotid neoplasm with intratemporal invasion through the facial nerve, such as adenoid cystic carcinoma.
  • CASE REPORT: We describe a case of parotid adenoid cystic carcinoma invading the temporal bone via the facial nerve, presenting as primary temporal bone tumour with parotid tissue involvement.
  • CONCLUSION: Tumours mimicking temporal bone neoplasms can originate from the parotid tissue and invade through the facial nerve.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology. Skull Neoplasms / pathology. Temporal Bone / pathology
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Radiotherapy Dosage. Tomography, X-Ray Computed

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  • (PMID = 17970441.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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92. Bhatia KS, Rasalkar DD, Lee YP, Wong KT, King AD, Yuen HY, Ahuja AT: Evaluation of real-time qualitative sonoelastography of focal lesions in the parotid and submandibular glands: applications and limitations. Eur Radiol; 2010 Aug;20(8):1958-64
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  • [Title] Evaluation of real-time qualitative sonoelastography of focal lesions in the parotid and submandibular glands: applications and limitations.
  • OBJECTIVE: To evaluate qualitative ultrasound elastography for focal salivary gland masses identified during routine clinical practice.
  • METHODS: Sixty-five parotid or submandibular masses in 61 patients underwent real-time qualitative ultrasound elastography and were scored on colour-scaled elastograms in terms of their stiffness relative to adjacent normal salivary parenchyma from ES 1 (soft) to ES 4 (stiff).
  • This was correlated with diagnosis from aspiration cytology or histology.
  • RESULTS: There were 29 Warthin's tumours (WTs), 23 pleomorphic adenomas (PAs), 2 adenoid cystic carcinomas, 1 adenosquamous carcinoma, 1 nodal metastasis from nasopharyngeal carcinoma, 1 lymphoma (2 deposits), 3 Kuttner tumours and 4 cases of Kimura's disease.
  • Nine, 19, 14 and 17 of the benign masses and 0, 1, 2 and 3 of the malignant masses were ES 1, 2, 3 and 4 respectively.
  • CONCLUSION: These preliminary findings suggest that qualitative real-time ultrasound elastography, although an ancillary technique to conventional ultrasound in the salivary glands, is likely to have a poor ability to discriminate benign lesions (particularly PAs) from malignant disease.
  • [MeSH-major] Elasticity Imaging Techniques / methods. Parotid Gland / diagnostic imaging. Parotid Neoplasms / diagnostic imaging. Submandibular Gland / diagnostic imaging. Submandibular Gland Neoplasms / diagnostic imaging

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  • (PMID = 20407904.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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93. Monteiro LS, Bento MJ, Palmeira C, Lopes C: Epidermal growth factor receptor immunoexpression evaluation in malignant salivary gland tumours. J Oral Pathol Med; 2009 Jul;38(6):508-13
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  • [Title] Epidermal growth factor receptor immunoexpression evaluation in malignant salivary gland tumours.
  • OBJECTIVE: The aim of this study was to determine epidermal growth factor receptor (EGFR) expression in malignant salivary gland tumours and its possible relationships with clinical and morphological findings, disease course and prognosis.
  • PATIENTS AND METHODS: The study sample comprised 88 patients diagnosed and treated for primary malignant salivary gland tumours between January 1992 and December 2002.
  • CONCLUSION: EGFR is not a useful indicator of prognosis in malignant salivary gland tumours.
  • However, the EGFR expression in salivary gland cancers like adenocarcinomas, undifferentiated carcinomas, mucoepidermoid carcinomas or salivary duct carcinomas suggests that these tumours may be a candidate for therapy investigation directed at EGFR.
  • [MeSH-major] Receptor, Epidermal Growth Factor / analysis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma / pathology. Carcinoma / surgery. Carcinoma, Acinar Cell / pathology. Carcinoma, Acinar Cell / surgery. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Ductal / pathology. Carcinoma, Ductal / surgery. Carcinoma, Mucoepidermoid / pathology. Carcinoma, Mucoepidermoid / surgery. Cell Membrane / pathology. Cytoplasm / pathology. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery. Prognosis. Retrospective Studies. Salivary Glands, Minor / pathology. Salivary Glands, Minor / surgery. Survival Rate. Young Adult

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  • (PMID = 19317849.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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94. Yu GY, Ma DQ, Gao Y: [Basic and clinical research on salivary gland tumors]. Beijing Da Xue Xue Bao; 2008 Feb 18;40(1):7-10
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  • [Title] [Basic and clinical research on salivary gland tumors].
  • Salivary gland tumors are a group of the most common tumors in the oral and maxillofacial region.
  • There is little knowledge on the clinicopathologic characteristics and clinical behaviors of salivary gland tumors of various locations and subtype.
  • The management of salivary gland tumors is also controversial.
  • Therefore adjunctive methods are important for preoperative diagnosis.
  • Since 1985, our research group has performed a series of basic and clinical researches on salivary gland tumors including clinicopathologic characteristics and behavior, preoperative adjunctive diagnosis, mechanism, prevention and treatment of distant metastasis of salivary adenoid cystic carcinoma, and histogenesis of salivary gland tumor.
  • These studies have improved our knowledge on the clinical, histopathological, cytological, imaging features, and bio-behavior of different types of salivary gland tumors.
  • We have also suggested related principles of management, modified the operative methods of benign tumor of parotid gland.
  • Our efforts have raised the standards of diagnosis and treatment of salivary gland tumors.
  • [MeSH-major] Salivary Gland Neoplasms
  • [MeSH-minor] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / surgery. Humans

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  • (PMID = 18278128.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
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95. Subhashraj K: Salivary gland tumors: a single institution experience in India. Br J Oral Maxillofac Surg; 2008 Dec;46(8):635-8
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  • [Title] Salivary gland tumors: a single institution experience in India.
  • Between 1991 and 2006, 684 cases of salivary gland tumours were analysed retrospectively, of which 422 (62%) were benign and 262 (38%) malignant.
  • Sixty-one percent of tumours were in the parotid gland, 22% in the minor salivary glands, and 17% in the submandibular glands.
  • The most common benign tumour was pleomorphic adenoma (86%), and the most common malignant tumours were adenoid cystic carcinoma (25%) and mucoepidermoid carcinoma (18%).
  • Among the minor salivary gland tumours, most were seen in the palate (68%).
  • We analyse the incidence and distribution of all types of salivary gland tumours in an Indian series, and provide data for comparison with other epidemiological studies from different geographical sites and races.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Child. Child, Preschool. Female. Humans. India / epidemiology. Male. Middle Aged. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor. Sex Ratio. Submandibular Gland Neoplasms / epidemiology. Young Adult

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  • (PMID = 18620785.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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96. Atarbashi Moghadam S, Atarbashi Moghadam F, Dadfar M: Epithelial salivary gland tumors in ahvaz, southwest of iran. J Dent Res Dent Clin Dent Prospects; 2010;4(4):120-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial salivary gland tumors in ahvaz, southwest of iran.
  • BACKGROUND AND AIMS: Salivary gland tumors are rare and specific lesions.
  • This study was carried out to determine the prevalence of major and minor salivary gland tumors in Ahvaz in the south of Iran.
  • RESULTS: Of 112 cases, 84 cases were benign and 28 cases were malignant.
  • The incidence of malignant salivary gland tumors increased with age and male predominance was found in malignant tumors.
  • The majority of the tumors occurred in parotid gland.
  • Mucoepidermoid carcinoma and adenoid cystic carcinoma were the most common malignant tumors.
  • CONCLUSION: It was shown that the peak incidence age of all salivary gland tumors was the third to fifth decades, and malignant tumors mostly occurred in the sixth to eighth decades.
  • Female predominance for all the tumors and slight male predominance in malignant tumors were observed.
  • The most common malignant tumors were mucoepidermoid carcinoma and adenoid cystic carcinoma.

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  • (PMID = 23346338.001).
  • [ISSN] 2008-210X
  • [Journal-full-title] Journal of dental research, dental clinics, dental prospects
  • [ISO-abbreviation] J Dent Res Dent Clin Dent Prospects
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3429964
  • [Keywords] NOTNLM ; Epithelial salivary gland tumors / major salivary gland tumors / minor salivary gland tumors / salivary gland
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97. Musani MA, Sohail Z, Zafar S, Malik S: Morphological pattern of parotid gland tumours. J Coll Physicians Surg Pak; 2008 May;18(5):274-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphological pattern of parotid gland tumours.
  • OBJECTIVE: To determine the morphological pattern of parotid tumours.
  • PATIENTS AND METHODS: During this study, 204 patients with parotid tumours were registered.
  • RESULTS: Out of 204 cases, 152 (74.5%) were benign and 52 (25.5%) were malignant.
  • Benign tumours were more common in females whereas malignant tumours were common in males.
  • The mean age of patients was 34 years and 42 years for benign and malignant tumours respectively.
  • The most common malignant tumour was mucoepidermoid carcinoma (60%), followed by adenoid cystic carcinoma.
  • Superficial lobe of parotid gland was the commonest site, 120 benign and all 52 malignant tumours arising from it while 32 benign tumours originated from deep lobe.
  • Parotid swelling for years was main feature of benign tumours, whereas malignant tumours presented with pain, fixation to skin or underlying structure, cervical lymphadenopathy and facial palsy.
  • CONCLUSION: Pleomorphic adenoma was the most common benign tumour and mucoepidermoid carcinoma was most common malignant tumour.
  • [MeSH-major] Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Fine-Needle. Child. Diagnosis, Differential. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Morbidity / trends. Neoplasm Staging / methods. Pakistan / epidemiology. Retrospective Studies. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 18541080.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Pakistan
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98. Vacchi-Suzzi M, Bocciolini C, Bertarelli C, Dall'Olio D: Ki-67 proliferation rate as a prognostic marker in major salivary gland carcinomas. Ann Otol Rhinol Laryngol; 2010 Oct;119(10):677-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ki-67 proliferation rate as a prognostic marker in major salivary gland carcinomas.
  • OBJECTIVES: The study was performed to evaluate the prognostic relevance of cell proliferation associated with Ki-67/ Mib-1 immunostaining in malignant tumors of the major salivary glands.
  • METHODS: Cell proliferation was evaluated by Mib-1 antibody against Ki-67 antigen in 41 patients with cancer of the parotid or submandibular glands, including 14 acinic cell carcinomas, 12 ductal carcinomas, 7 mucoepidermoid carcinomas, 5 carcinomas ex pleomorphic adenoma, 1 adenoid cystic carcinoma, 1 undifferentiated carcinoma, and 1 polymorphous low-grade adenocarcinoma.
  • CONCLUSIONS: To our knowledge, this is the first study to stratify different risk classes in early T1-T2 or N0 malignant tumors of the major salivary glands that identified aggressive lesions with elevated Ki-67 expression at an initial stage.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers / analysis. Carcinoma, Acinar Cell / mortality. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Ductal / mortality. Carcinoma, Mucoepidermoid / mortality. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Parotid Neoplasms / mortality. Prognosis. Salivary Gland Neoplasms / mortality. Submandibular Gland Neoplasms / mortality

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  • (PMID = 21049853.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Ki-67 Antigen
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99. Nepal A, Chettri ST, Joshi RR, Bhattarai M, Ghimire A, Karki S: Primary salivary gland tumors in eastern Nepal tertiary care hospital. J Nepal Health Res Counc; 2010 Apr;8(1):31-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary salivary gland tumors in eastern Nepal tertiary care hospital.
  • BACKGROUND: The knowledge of the distribution and pattern of salivary gland tumors in the tertiary care center can provide overview of the disease pattern in the region.
  • METHODS: A retrospective observational study of all the salivary gland tumors treated in the department of Otolaryngology, B. P.
  • RESULTS: Out of total 51 cases, 81% (n=41) were benign and 19% (n=10) malignant tumors.
  • Mean age for benign and malignant tumors were 32.3 and 46.5 years respectively.
  • Parotid tumor outnumbered all other sites comprising 69%, followed by submandiibular 18% and minor glands 13%.
  • Pleomorphic adenoma was the commonest tumor (76%) of all primary salivary gland tumors.
  • Benign to malignant tumor ratio of parotid, submandibular and minor glands were 6:1, 3.5:1 and 1.3:1 respectively.
  • Adenoid cystic carcinoma (40%) and mucoepidermoid carcinoma (30%) were commonest malignant tumors.
  • CONCLUSIONS: The principal site for salivary gland tumors in eastern Nepal population was the parotid and the pleomorphic adenoma outnumbered all other tumors.
  • Most of the cases in both benign and malignant group presented with painless lump often misleading the gravity of disease.
  • [MeSH-major] Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Middle Aged. Nepal. Parotid Gland / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Retrospective Studies. Salivary Glands / pathology. Young Adult

  • MedlinePlus Health Information. consumer health - Salivary Gland Cancer.
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  • (PMID = 21879011.001).
  • [ISSN] 1999-6217
  • [Journal-full-title] Journal of Nepal Health Research Council
  • [ISO-abbreviation] J Nepal Health Res Counc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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100. Okada T, Saito K, Takahashi M, Hasegawa Y, Fujimoto Y, Terada A, Kamei Y, Yoshida J: En bloc petrosectomy for malignant tumors involving the external auditory canal and middle ear: surgical methods and long-term outcome. J Neurosurg; 2008 Jan;108(1):97-104
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] En bloc petrosectomy for malignant tumors involving the external auditory canal and middle ear: surgical methods and long-term outcome.
  • OBJECTIVES: The aim of this study was to describe a method for resecting malignant tumors originating in the external auditory canal or middle ear and requiring en bloc resection of the petrous bone.
  • METHODS: Between 1995 and 2005, the authors performed en bloc petrosectomy for 18 malignant tumors in 9 male and 9 female patients, ranging in age from 15 to 74 years.
  • Fourteen tumors originated in the external ear, 2 in the middle ear, and 2 in the parotid gland.
  • The pathological entities included 15 squamous cell carcinomas, 2 adenoid cystic carcinomas, and 1 rhabdomyosarcoma.
  • CONCLUSIONS: En bloc petrosectomy is recommended for malignant tumors of the ear.
  • [MeSH-major] Carcinoma / surgery. Ear Canal. Ear Neoplasms / surgery. Ear, Middle. Osteotomy / methods. Petrous Bone. Rhabdomyosarcoma / surgery

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  • (PMID = 18173317.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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