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1. Dores GM, Huycke MM, Devesa SS, Garcia CA: Primary cutaneous adenoid cystic carcinoma in the United States: incidence, survival, and associated cancers, 1976 to 2005. J Am Acad Dermatol; 2010 Jul;63(1):71-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous adenoid cystic carcinoma in the United States: incidence, survival, and associated cancers, 1976 to 2005.
  • BACKGROUND: Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare appendageal tumor of uncertain origin.
  • [MeSH-major] Carcinoma, Adenoid Cystic / epidemiology. Skin Neoplasms / epidemiology
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / epidemiology. Survival Rate. United States / epidemiology

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  • [Copyright] Copyright (c) 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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  • (PMID = 20447723.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CP010183-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS135983; NLM/ PMC2885489
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2. Singh A, Ramesh V: Primary cutaneous adenoid cystic carcinoma with distant metastasis: a case report and brief literature review. Indian J Dermatol Venereol Leprol; 2010 Mar-Apr;76(2):176-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous adenoid cystic carcinoma with distant metastasis: a case report and brief literature review.
  • Primary adenoid cystic carcinoma (PCACC) of skin is a rare tumor, and those who show distant metastasis are even rarer.
  • We report a case of PCACC on the face of a 55-year-old man who showed bilateral lung metastasis and on palliative chemotherapy showed significant regression of the primary tumor.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 20228549.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 11
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3. Xu YG, Hinshaw M, Longley BJ, Ilyas H, Snow SN: Cutaneous adenoid cystic carcinoma with perineural invasion treated by mohs micrographic surgery-a case report with literature review. J Oncol; 2010;2010:469049

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous adenoid cystic carcinoma with perineural invasion treated by mohs micrographic surgery-a case report with literature review.
  • We report a 58-year-old woman with cutaneous adenoid cystic carcinoma arising on the chest treated with Mohs micrographic surgery.
  • To date, only six other cases of cutaneous adenoid cystic carcinoma were reportedly managed by Mohs surgery.
  • Cutaneous adenoid cystic carcinoma has low potential for distant metastasis but is notorious for its aggressive infiltrative growth pattern, frequent perineural invasion, and high risk of local recurrence after excision.
  • We propose that Mohs surgery is an ideal method to achieve margin-free removal of cutaneous adenoid cystic carcinoma.

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  • (PMID = 20379385.001).
  • [ISSN] 1687-8469
  • [Journal-full-title] Journal of oncology
  • [ISO-abbreviation] J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2850546
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4. Albores-Saavedra J, Heard SC, McLaren B, Kamino H, Witkiewicz AK: Cylindroma (dermal analog tumor) of the breast: a comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast. Am J Clin Pathol; 2005 Jun;123(6):866-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cylindroma (dermal analog tumor) of the breast: a comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast.
  • We compared 4 breast cylindromas with 50 dermal cylindromas and 8 adenoid cystic breast carcinomas.
  • Except for a modest increase in the number of eccrine ducts and reactive Langerhans cells in dermal cylindromas, breast and dermal cylindromas showed identical histologic and immunohistochemical features.
  • Clusters of sebaceous cells and a few eccrine ducts are described in breast cylindromas.
  • Eccrine ducts were highlighted by epithelial membrane antigen and carcinoembryonic antigen.
  • Cylindromas of the breast and skin did not express cytokeratin 20, gross cystic disease fluid protein 15, or estrogen or progesterone receptor.
  • Breast cylindroma might be confused with the solid variant of adenoid cystic carcinoma, especially in needle core biopsy specimens, because they share nodular and trabecular patterns, basaloid cells, myoepithelial cells, eccrine ducts, and hyaline globules of basement membrane material.
  • However, adenoid cystic carcinoma displays an infiltrative growth pattern, cytologic atypia, and mitotic figures and lacks the continuous, thickened basement membrane.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Sweat Glands / pathology

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  • (PMID = 15899777.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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5. Yamada T, Mouri H, Izumi K, Takeuchi S, Ohtsubo K, Yamashita K, Yasumoto K, Kitamura S, Yano S: [Combined chemotherapy with cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1545-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Combined chemotherapy with cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma].
  • We report a case of a 65-year-old man with metastatic primary cutaneous adenoid cystic carcinoma that was effectively treated by combination chemotherapy with cisplatin (CDDP) plus vinorelbine(VNR).
  • He was given a diagnosis of primary cutaneous adenoid cystic carcinoma with metastatic lesions to multiple lungs and left tibial bone and then given chemotherapy combining CDDP plus VNR as the first treatment in December 2008.
  • We reported the efficacy of combined treatment with CDDP plus VNR for primary cutaneous adenoid cystic carcinoma, because this clinical condition was very rare and the standard treatment has still not been established.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Cisplatin / therapeutic use. Lung Neoplasms / drug therapy. Skin Neoplasms / drug therapy. Vinblastine / analogs & derivatives

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  • (PMID = 20716883.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; Q6C979R91Y / vinorelbine
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6. Naylor E, Sarkar P, Perlis CS, Giri D, Gnepp DR, Robinson-Bostom L: Primary cutaneous adenoid cystic carcinoma. J Am Acad Dermatol; 2008 Apr;58(4):636-41
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous adenoid cystic carcinoma.
  • Primary cutaneous adenoid cystic carcinoma is a rare, slow-growing malignancy first described by Boggio in 1975.
  • This tumor characteristically consists of basophilic cells with a distinct adenoid or cribriform pattern in the mid to deep reticular dermis.
  • Definitive diagnosis relies on the characteristic histologic features and the exclusion of metastatic disease.
  • [MeSH-major] Carcinoma, Adenoid Cystic / ultrastructure. Head and Neck Neoplasms / ultrastructure. Scalp. Skin Neoplasms / ultrastructure

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  • (PMID = 18342709.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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7. Perez DE, Magrin J, de Almeida OP, Kowalski LP: Multiple cutaneous metastases from a parotid adenoid cystic carcinoma. Pathol Oncol Res; 2007;13(2):167-9
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple cutaneous metastases from a parotid adenoid cystic carcinoma.
  • Cutaneous metastasis from salivary gland adenoid cystic carcinoma is extremely rare.
  • We report a case of a 39-year-old man that presented multiple cutaneous metastases from a parotid salivary gland adenoid cystic carcinoma.
  • This case shows the importance of a detailed and periodical skin examination in patients treated for salivary gland adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Parotid Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Gene Expression Regulation, Neoplastic. Humans. Keratin-7 / genetics. Keratin-7 / metabolism. Male. Proto-Oncogene Proteins c-kit / genetics. Proto-Oncogene Proteins c-kit / metabolism. Skin / metabolism. Skin / pathology. Vimentin / genetics. Vimentin / metabolism

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  • (PMID = 17607381.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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8. Masih I, Porter G, Porter S, Clarke R, Sidhu P, Harney J, McCarthy A, Convery R: Primary adenoid cystic carcinoma of the bronchus in a female teenager. BMJ Case Rep; 2010;2010
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenoid cystic carcinoma of the bronchus in a female teenager.
  • Primary adenoid cystic carcinoma (ACC) of the lung is an extremely rare malignant lung neoplasm.
  • ACC of salivary glands of the head and neck, lachrymal glands, breast, skin, vulva and trachea have been frequently reported disease patterns in the literature, but it is unique to see this rare lung tumour in a patient as young as 14 years old.
  • Our report of primary lung ACC in a young girl is a complex case due to young age, a different way of presentation and staging on diagnosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 22798097.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC3027792
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9. Barnes J, Garcia C: Primary cutaneous adenoid cystic carcinoma: a case report and review of the literature. Cutis; 2008 Mar;81(3):243-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous adenoid cystic carcinoma: a case report and review of the literature.
  • Primary cutaneous adenoid cystic carcinoma is a rare cancer, with only 61 cases reported in the literature.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Surgical Flaps

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  • (PMID = 18441847.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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10. Fueston JC, Gloster HM, Mutasim DF: Primary cutaneous adenoid cystic carcinoma: a case report and literature review. Cutis; 2006 Mar;77(3):157-60
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous adenoid cystic carcinoma: a case report and literature review.
  • Primary cutaneous adenoid cystic carcinoma (ACC) is a rare tumor, with less than 50 cases reported to date.
  • We report an additional case of primary cutaneous ACC arising on the scalp of a 57-year-old woman.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / pathology

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  • (PMID = 16610734.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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11. Alfaro-Rubio A, Sanmartín Jiménez O, Serra-Guillén C, Requena Caballero C, Hueso Gabriel L, Botella-Estrada R, Nagore Enguídanos E, Llombart Cussac B, Guillén Barona C: [Adenoid cystic carcinoma]. Actas Dermosifiliogr; 2006 Nov;97(9):578-80
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  • [Title] [Adenoid cystic carcinoma].
  • [Transliterated title] Carcinoma adenoide quístico.
  • Adenoid cystic carcinoma is an uncommon tumor of the head and neck.
  • Although it is mainly located in the salivary gland, a skin location has also been described.
  • After resection, the histological diagnosis was adenoid cystic carcinoma.
  • Its histological diagnosis was lymphatic metastasis due to adenoid cystic carcinoma.
  • Primary cutaneous adenoid cystic carcinoma is a very uncommon tumor in which treatment consists in extensive local excision with free margins.
  • Multicenter, prospective studies are necessary to determine the best treatment and especially the adjuvant treatment for adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lip Neoplasms / pathology

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  • (PMID = 17173761.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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12. Cansu DU, Kasifoglu T, Açkaln M, Korkmaz C: The development of primary cutaneous adenoid cystic carcinoma in a patient with ankylosing spondylitis treated with etanercept. South Med J; 2009 Jul;102(7):738-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The development of primary cutaneous adenoid cystic carcinoma in a patient with ankylosing spondylitis treated with etanercept.
  • The case of a patient with ankylosing spondylitis who developed cutaneous adenoid cystic carcinoma after three years of treatment with anti-TNF-alpha therapy is discussed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / chemically induced. Immunoglobulin G / adverse effects. Immunosuppressive Agents / adverse effects. Skin Neoplasms / chemically induced. Spondylitis, Ankylosing / drug therapy


13. Xia Y, Xu S, Liu X, Chen AC: Photodynamic therapy as consolidation treatment for primary cutaneous adenoid cystic carcinoma: a case report. Photomed Laser Surg; 2010 Oct;28(5):707-10
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  • [Title] Photodynamic therapy as consolidation treatment for primary cutaneous adenoid cystic carcinoma: a case report.
  • OBJECTIVE: The purpose of this case report was to evaluate the efficacy of photodynamic therapy (PDT) for a patient with primary cutaneous adenoid cystic carcinoma (PCACC).
  • After performing a local resection along a margin of 0.5 cm beyond the surrounding tissue, PCACC was clearly revealed based on the histological features and the exclusion of differentiation of other metastasis in the skin.
  • RESULTS: The 40-month follow-up diagnosis showed no evidence of recurrence or metastasis observed on the treated area.
  • [MeSH-major] Aminolevulinic Acid / administration & dosage. Carcinoma, Adenoid Cystic / therapy. Facial Neoplasms / therapy. Photochemotherapy / methods. Skin Neoplasms / therapy. Surgical Procedures, Operative / methods

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  • (PMID = 20929386.001).
  • [ISSN] 1557-8550
  • [Journal-full-title] Photomedicine and laser surgery
  • [ISO-abbreviation] Photomed Laser Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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14. Benchetritt M, Butori C, Long E, Ilie M, Ferrari E, Hofman P: Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: diagnostic cytopathology from an exfoliative sample. Diagn Cytopathol; 2008 May;36(5):351-4
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  • [Title] Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: diagnostic cytopathology from an exfoliative sample.
  • Adenoid cystic carcinoma (ACC) occurs not only as a tumor of salivary glands, but also in very unusual locations, such as in the skin.
  • Only very few cases of primary cutaneous of ACC have metastasized to the lymph nodes and lungs.
  • We present a 53-year-old man with metastasis of the pericardium from a primary cutaneous ACC (PCACC) of the scalp, which had been surgically treated 14 years ago.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Heart Neoplasms / secondary. Pericardial Effusion / pathology. Pericardium / pathology. Skin Neoplasms / pathology

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  • (PMID = 18418850.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Popa I, Welt L, Constantin G, Popa E, Bordea A, Burcoş T, Iosif C, Angelescu N: [Adenoid cystic carcinoma of the breast--two case reports]. Chirurgia (Bucur); 2010 Nov-Dec;105(6):827-30
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  • [Title] [Adenoid cystic carcinoma of the breast--two case reports].
  • [Transliterated title] Carcinom adenoid chistic mamar--prezentare a două cazuri.
  • Adenoid cystic carcinoma is a rare type of breast carcinoma with a good prognosis.
  • We present two cases of adenoid cystic carcinoma diagnosed in the Surgical Department of Coltea Hospital in the last 3 years.
  • The first case is a 66 years old patient with a breast tumor that has clinical and imagistic features compatible with a benign diagnosis.
  • The frozen sections established the diagnosis of adenoid cystic carcinoma, confirmed by histopathologic examination of paraffin embedded tissue and immunohistochemistry.
  • The second case is a 68 years old patient with a breast tumor located in the central quadrant of the left breast, with skin infiltration.
  • The frozen sections established the diagnosis of ductal invasive carcinoma and histopathologic examination of paraffin embedded tissue and immunohistochemistry established the diagnosis of adenoid cystic carcinoma associated with ductal invasive carcinoma grade I and adenomyoepitelioma.
  • [MeSH-major] Adenomyoepithelioma / pathology. Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Carcinoma, Ductal, Breast / pathology. Diagnosis, Differential. Female. Humans. Lymph Node Excision. Mastectomy. Neoplasm Staging. Treatment Outcome

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  • (PMID = 21355181.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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16. Rütten A, Requena L: [Sweat gland carcinomas of the skin]. Hautarzt; 2008 Feb;59(2):151-60

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  • [Title] [Sweat gland carcinomas of the skin].
  • Sweat gland carcinomas are rare malignant tumors of the skin.
  • The well-defined entities porocarcinoma, microcystic adnexal carcinoma, aggressive digital papillary adenocarcinoma, mucinous eccrine carcinoma, adenoid cystic carcinoma, spiradenocarcinoma, cylindrocarcinoma, hidradenocarcinoma are described.
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / therapy

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  • (PMID = 18214401.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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17. Schmaltz R, Müller CS, Vogt T: [Sudden growth of previously indolent scalp nodule]. Hautarzt; 2010 Jun;61(6):518-21
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  • Cylindromas are benign adnexal tumors with eccrine and apocrine differentiation.
  • Malignant changes are rare; possible clues are ulceration, bleeding or sudden growth of the lesions.
  • We present a case of scalp cylindromatosis in which a primary cutaneous adenoid-cystic carcinoma developed.
  • As our case shows, histological evaluation is mandatory, even when the clinical diagnosis seems obvious.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Cell Transformation, Neoplastic / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Multiple Primary / diagnosis. Scalp. Skin Neoplasms / diagnosis

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  • (PMID = 20490442.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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18. Kim UR, Shah AD, Shanti R, Arora V: Primary adenoid cystic carcinoma of the eyelid. Ophthal Plast Reconstr Surg; 2010 Mar-Apr;26(2):134-6
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  • [Title] Primary adenoid cystic carcinoma of the eyelid.
  • Adenoid cystic carcinoma is a rare epithelial malignancy, which tends to grow slowly.
  • An excisional biopsy with wide margins revealed a diagnosis of primary adenoid cystic carcinoma of eyelid skin with perineural invasion.
  • Although a rare neoplasm, primary adenoid cystic carcinoma of eyelid skin should be included in the differential diagnosis of eyelid tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Eyelid Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 20305522.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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19. Kshirsagar AY, Wader JV, Langade YB, Jadhav KP, Zaware SU, Shekhar N: Adenoid cystic carcinoma of the male breast. Int Surg; 2006 Jul-Aug;91(4):234-6
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  • [Title] Adenoid cystic carcinoma of the male breast.
  • This was histopathologically diagnosed as an adenoid cystic carcinoma of the left breast.
  • Periodic acid schiff (PAS) staining confirmed the diagnosis.
  • Wide excision of the recurrent malignant nodules over the anterior chest wall was done, and the defect was covered primarily with split thickness skin grafting.
  • [MeSH-major] Breast Neoplasms, Male / surgery. Carcinoma, Adenoid Cystic / surgery

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  • (PMID = 16967686.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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20. Yurut-Caloglu V, Caloglu M, Ozyilmaz F, Saynak M, Cosar-Alas R, Karagol H, Bayir-Angin G, Uzal C: Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature. Med Oncol; 2007;24(4):458-62
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  • [Title] Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature.
  • Adenoid cystic carcinoma is the second most common malignancy of the major and minor salivary glands after mucoepidemoid carcinoma.
  • Skeletal muscle and cutaneous metastases from adenoid cystic carcinoma of the parotid gland are extremely rare.
  • In this case, a 40-year-old man with lung and bone metastases followed by skeletal muscle and cutaneous metastases from adenoid cystic carcinoma of the right parotid gland is presented.
  • [MeSH-major] Bone Neoplasms / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis. Muscle Neoplasms / diagnosis. Parotid Neoplasms / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 17917100.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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21. González-Vela MC, Val-Bernal JF, Mayorga M, Zaldumbide L, Báscones M: Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma. APMIS; 2006 Jun;114(6):470-3
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  • [Title] Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma.
  • Adenoid squamous cell carcinoma (ASCC) or acantholytic squamous cell carcinoma is a well-recognized variant of squamous cell carcinoma.
  • ASCC commonly occurs in the sun-exposed areas of the skin and has only rarely been observed in mucosal sites.
  • Biopsy was performed and the histological diagnosis was squamous cell carcinoma.
  • Microscopically, the tumor showed a prominent alveolar pattern with cystic degeneration of the neoplastic epithelium and formation of pseudoglandular structures.
  • Transition areas from conventional squamous cell carcinoma to adenoid pattern were found.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 16856971.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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22. Laco J, Simáková E, Svobodová J, Ryska A: Recurrent mucinous carcinoma of skin mimicking primary mucinous carcinoma of parotid gland: a diagnostic pitfall. Cesk Patol; 2009 Jul;45(3):79-82
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  • [Title] Recurrent mucinous carcinoma of skin mimicking primary mucinous carcinoma of parotid gland: a diagnostic pitfall.
  • Examination by fine needle aspiration cytology raised suspicion of mucoepidermoid or adenoid cystic carcinoma of the parotid gland and an excision was recommended.
  • Retrospective analysis of a skin biopsy from the same anatomic area performed 8 years prior to parotid neoplasm displayed a tumor with identical microscopic appearance and immunohistochemical profile (additionally performed) which was, however, misdiagnosed as a benign lesion.
  • The diagnosis of recurrent primary mucinous carcinoma of the skin infiltrating the parotid gland was established.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / diagnosis. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 19764163.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
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23. Goto H, Yamamoto T, Ishiyama Z, Usui M, Okada S: Adenoid cystic carcinoma arising from the lower eyelid. Jpn J Ophthalmol; 2006 Jul-Aug;50(4):374-6
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  • [Title] Adenoid cystic carcinoma arising from the lower eyelid.
  • BACKGROUND: Primary cutaneous adenoid cystic carcinoma is one of the rarest eyelid tumors.
  • OBSERVATIONS: Under a clinical diagnosis of chalazion, the eyelid induration was extracted surgically via the palpebral conjunctiva.
  • Histopathological examination of the extracted tumor revealed proliferation of basaloid cells with a prominent cribriform pattern containing Alcian blue-positive and periodic acid Schiff-positive material, leading to a diagnosis of adenoid cystic carcinoma.
  • CONCLUSIONS: Adenoid cystic carcinoma should be considered as a differential diagnosis of eyelid tumors simulating chalazion.
  • Adenoid cystic carcinoma in the eyelid may have a more favorable prognosis than that in the lacrimal gland.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Eyelid Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Ophthalmologic Surgical Procedures

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  • [Copyright] Copyright (c) Japanese Ophthalmological Society 2006.
  • (PMID = 16897224.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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24. Brandt SM, Swistel AJ, Rosen PP: Secretory carcinoma in the axilla: probable origin from axillary skin appendage glands in a young girl. Am J Surg Pathol; 2009 Jun;33(6):950-3
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  • [Title] Secretory carcinoma in the axilla: probable origin from axillary skin appendage glands in a young girl.
  • Invasive carcinoma in the axilla may arise from skin appendage glands or ectopic breast tissue or it may be a metastasis.
  • Carcinomas of the skin adnexal glands and breast can be difficult to distinguish from each other as they often display the same patterns of growth.
  • Tubular, cribriform, papillary, apocrine, mucinous, and adenoid cystic are histologic types of carcinoma seen in the breast and skin appendage glands.
  • To our knowledge, secretory carcinoma, the most common form of mammary carcinoma in children, has not yet been described as a morphologic pattern of skin adnexal carcinoma, although we cannot exclude the possibility that such a case was reported with a different diagnosis.
  • We report a case of a young girl with secretory carcinoma that seems to have arisen from skin appendage glands in the skin of the axilla in the absence of demonstrable ectopic breast tissue.
  • [MeSH-major] Axilla / pathology. Carcinoma, Skin Appendage / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Am J Surg Pathol. 2010 Aug;34(8):1226-7; author reply 1228 [20631609.001]
  • (PMID = 19342945.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Puizina-Ivić N, Sapunar D, Marasović D, Mirić L: An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis. Coll Antropol; 2008 Oct;32 Suppl 2:61-5
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  • [Title] An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis.
  • In this study the authors have analyzed imunohistochemically the expression of Bcl-2 protein in the histopathological variants of the most common malignant tumors of the skin--basal cell carcinoma (BCC) and squamous cell tumor (SCC), as well as in the precancerous lesion actinic keratosis (AK) and in benign tumor seborrheic keratosis (SK).
  • Bcl-2 expression in solid, adenoid and cystic variants of BCC exhibited immunoreactivity of tumor stroma with more intense staining among peripheral palisading cells.
  • In three histological variants of SK expresseion of Bcl-2 protein was in areas of basaloid proliferation, while in areas of squamous differentiation was negative.
  • In clonal variant immunostaining was positive among cells in characteristic "nests" Distribution of Bcl-2 protein expression in solid, adenoid and cystic variant of BCC showed that peripheral proliferating cells are protected against apoptosis what permits tumor growth.
  • In AK results suggest that immunoreactivity is regulated with respect of the keratinocyte's differentiation status, but not closely correlate with proliferative rate.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Keratosis, Actinic / metabolism. Keratosis, Seborrheic / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Skin Neoplasms / metabolism


26. Jukic DM, Drogowski LM, Davie JR: Carcinoma ex spiradenoma/cylindroma confirmed by immunohistochemical and molecular loss-of-heterozygosity profiling. Am J Dermatopathol; 2009 Oct;31(7):702-8
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  • [Title] Carcinoma ex spiradenoma/cylindroma confirmed by immunohistochemical and molecular loss-of-heterozygosity profiling.
  • We present a case of spiradenoma/cylindroma with admixed carcinoma of unknown origin, resolved using immunohistochemical and molecular loss-of-heterozygosity (LOH) profiling.
  • For 9 years, the patient remained disease free until complaining of a slow-growing skin nodule on the lower back that was excised under clinical suspicion of metastatic mammary carcinoma.
  • Histopathological exam revealed a benign eccrine spiradenoma/cylindroma and an intermixed carcinoma, with a differential diagnosis of either primary eccrine carcinoma or mammary carcinoma metastatic to the spiradenoma/cylindroma.
  • Histological features and immunohistochemical staining favored eccrine carcinoma but not unequivocally; therefore, LOH profiles were performed on archival paraffin block tissue from the 3 neoplastic lesions (4 components).
  • The mammary carcinomas showed disparate LOH at 5 of 7 (right breast) and 4 of 7 (left breast) informative genetic loci, establishing these carcinomas as separate primary neoplasms.
  • Both the spiradenoma/cylindroma and eccrine carcinoma revealed no LOH at the tested loci, establishing the unknown carcinoma as an independent carcinoma arising within a spiradenoma/cylindroma.
  • This neoplasm is referred to in the literature as carcinoma ex spiradenoma/cylindroma and spiradenocylindrocarcinoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Loss of Heterozygosity. Neoplasms, Second Primary / pathology. Polymerase Chain Reaction

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  • (PMID = 19684510.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. O'Blenes CA, Lee JP, Walsh NM, Morris SF: An unusual case of turban tumor syndrome treated with total scalp excision and advancement flap and skin graft reconstruction. Ann Plast Surg; 2010 Jul;65(1):107-9
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  • [Title] An unusual case of turban tumor syndrome treated with total scalp excision and advancement flap and skin graft reconstruction.
  • To address concerns regarding hygiene of the scalp and cosmetic disfigurement, she underwent total scalp excision with advancement flap and skin graft reconstruction.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Facial Neoplasms / surgery. Neoplasms, Adnexal and Skin Appendage / surgery. Neoplasms, Multiple Primary / surgery. Neoplasms, Second Primary / surgery. Scalp / surgery. Skin Neoplasms / surgery. Surgical Flaps

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  • (PMID = 20548229.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Rütten A, Kutzner H, Mentzel T, Hantschke M, Eckert F, Angulo J, Rodríguez Peralto JL, Requena L: Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm. J Am Acad Dermatol; 2009 Oct;61(4):644-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm.
  • BACKGROUND: Cribriform carcinoma is the histopathologic variant of cutaneous apocrine carcinoma characterized by interconnected solid aggregations of neoplastic cells that are punctuated by small round spaces.
  • OBJECTIVE: To describe the histopathologic and immunohistochemical characteristics of this under-recognized cutaneous adnexal neoplasm.
  • METHODS: Twenty-six cases of primary cutaneous cribriform apocrine carcinoma were clinically, histopathologically, and immunohistochemically studied.
  • CONCLUSIONS: Primary cutaneous cribriform apocrine carcinoma is a distinctive but little-known variant of cutaneous apocrine carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology
  • [MeSH-minor] Adult. Aged. Apocrine Glands / pathology. Biopsy. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cytoplasm / pathology. Cytoplasm / ultrastructure. Diagnosis, Differential. Epithelial Cells / pathology. Epithelial Cells / ultrastructure. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron. Microvilli / pathology. Microvilli / ultrastructure. Middle Aged. Young Adult

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  • [CommentIn] J Am Acad Dermatol. 2011 Mar;64(3):599-601 [21315957.001]
  • (PMID = 19751882.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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29. Kazakov DV, Kutzner H, Rütten A, Mukensnabl P, Michal M: Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma. Am J Dermatopathol; 2005 Jun;27(3):195-203
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma.
  • This report emphasizes a carcinoid-like pattern, a previously unrecognized feature in cutaneous sebaceous neoplasms.
  • The cases included 6 men and 1 woman, with their ages at the diagnosis ranging from 43 to 87 years (median age, 59).
  • Sebaceous differentiation in the form of mature sebocytes varied from almost none to approximately 10%.
  • Four lesions represented sebaceomas, and in 1 case microscopic delineation between a carcinoma and sebaceoma was difficult.
  • No neuroendocrine differentiation was demonstrated immunohistochemically, histochemically, and ultrastructurally.
  • Electron microscopic examination performed in 1 case of carcinoma revealed lipid vacuoles in a minority of cells.
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Diagnosis, Differential. Female. History, 16th Century. Humans. Immunohistochemistry. Inclusion Bodies / pathology. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / ultrastructure. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 15900121.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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30. Kacerovska D, Szepe P, Vanecek T, Nemcova J, Michal M, Mukensnabl P, Kazakov DV: Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations. Am J Dermatopathol; 2008 Oct;30(5):472-6
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  • [Title] Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations.
  • The authors report a case of basaloid carcinoma involving the anus and rectum of a 57-year-old woman.
  • Microscopically, the tumor showed unusual morphologic features strongly resembling a spiradenocylindroma because it consisted, in most parts, of basaloid cell nodules arranged in a jigsaw-puzzle fashion containing or surrounded by eosinophilic basal membrane material; in addition, there were intratumoral lymphocytes.
  • The overlying squamous epithelium manifested dysplastic changes compatible with in situ squamous carcinoma that gradually became invasive and blended with basaloid cell islands; additionally, there were koilocytes in the squamous epithelium.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Human papillomavirus 16 / pathogenicity. Rectal Neoplasms / pathology. Skin Neoplasms / pathology. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Middle Aged. Mutation / genetics

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  • (PMID = 18806492.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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31. Almeida S, Maillard C, Itin P, Hohl D, Huber M: Five new CYLD mutations in skin appendage tumors and evidence that aspartic acid 681 in CYLD is essential for deubiquitinase activity. J Invest Dermatol; 2008 Mar;128(3):587-93
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  • [Title] Five new CYLD mutations in skin appendage tumors and evidence that aspartic acid 681 in CYLD is essential for deubiquitinase activity.
  • Brooke-Spiegler syndrome, familial cylindromatosis, and familial trichoepithelioma are autosomal-dominant genetic predispositions for benign tumors of skin appendages caused by mutations in the CYLD gene localized on chromosome 16q12-q13.
  • We investigated five families affected with these skin neoplasms and identified four premature stop codons and the novel missense mutation D681G in a family in which 11 of 12 investigated tumors were trichoepitheliomas.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Mutation, Missense. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Adult. Amino Acid Sequence. Biopsy. Carcinoma, Skin Appendage / genetics. Carcinoma, Skin Appendage / metabolism. Carcinoma, Skin Appendage / pathology. Cell Line, Tumor. Codon, Terminator. Female. Humans. Male. Molecular Sequence Data. Pedigree. TNF Receptor-Associated Factor 2 / metabolism. TNF Receptor-Associated Factor 6 / metabolism. Ubiquitin / metabolism

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  • (PMID = 17851586.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Codon, Terminator; 0 / TNF Receptor-Associated Factor 2; 0 / TNF Receptor-Associated Factor 6; 0 / Tumor Suppressor Proteins; 0 / Ubiquitin
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32. Scott AR, Faquin WC, Deschler DG: Parotid mass in a woman with multiple cutaneous cylindromas. Head Neck; 2010 May;32(5):684-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid mass in a woman with multiple cutaneous cylindromas.
  • BACKGROUND: Familial autosomal dominant cylindromatosis (FADC) is a rare disease characterized by multiple cutaneous cylindromas, trichoepitheliomas, and spiradenomas.
  • METHODS: Biopsy of a skin nodule demonstrated cylindroma, and fine-needle aspiration of the parotid mass suggested membranous basal cell adenoma, which was confirmed following superficial parotidectomy.
  • Seventeen cases involved the parotid gland; there are 2 reports of malignant transformation.
  • Membranous basal cell adenoma may be mistaken for adenoid cystic carcinoma on cytologic or histologic examination.
  • Total parotidectomy with facial nerve preservation or superficial parotidectomy with close follow-up is recommended, as multifocality and malignant transformation exist.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19455704.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Fresini A, Rossiello L, Severino BU, Del Prete M, Satriano RA: Giant basal cell carcinoma. Skinmed; 2007 Jul-Aug;6(4):204-5
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  • [Title] Giant basal cell carcinoma.
  • A 72-year-old white man presented with a large cutaneous tumor on his back.
  • Perilesional skin appeared edematous, probably owing to inflammation and impaired lymphatic flow.
  • The tumor mostly showed an adenoid pattern: gland-like structures and cystic spaces sometimes containing amorphous or granular material, surrounded by strands of basaloid cells devoid of any peripheral palisading (Figure 2C).
  • In some areas, the adenoid pattern coexisted with infiltrated areas characterized by thin and elongated strands or cords of basaloid cells with irregular and jagged peripheral contours within a fibrous or edematous stroma (Figure 2D).
  • Therefore, a diagnosis of basal cell carcinoma, adenoid subtype, was made.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 17618177.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Paarlberg JC, van den Bosch WA, Paridaens D: Reconstruction following subtotal full-thickness upper eyelid resection with preservation of the lid margin. Orbit; 2007 Dec;26(4):319-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Radical excision of a large adenoid cystic carcinoma of the upper eyelid resulted in a subtotal full-thickness eyelid defect with preservation of 2 mm of eyelid margin.
  • Reconstruction was performed with a free transconjunctival graft of maximum size from the contralateral upper eyelid, an overlying bipedicled skin-orbicularis oculi muscle flap and a free skin graft.
  • [MeSH-major] Blepharoplasty / methods. Carcinoma, Adenoid Cystic / surgery. Eyelid Neoplasms / surgery

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  • (PMID = 18097977.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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35. Aksu K, Aktaş Z, Aksu F, Orsel O, Demirağ F, Sipit T, Firat Güven S: Spindle cell sarcomatoid carcinoma: first case reported in the trachea. Tuberk Toraks; 2009;57(3):337-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spindle cell sarcomatoid carcinoma: first case reported in the trachea.
  • Microscopically, the tumor was composed of fascicular pattern of spindle cells with atypical mitotic figures and nuclear pleomorphism, positively reactive to epithelial membrane antigen supporting a diagnosis of tumour with epithelial differentiation.
  • These findings supported the diagnosis of a spindle cell sarcomatoid carcinoma of trachea.
  • Spindle cell carcinoma cases are reported in many sites, such as head and neck region, larynx, digestive tract, breast, kidney, genital tract, skin and lung, but to our knowledge, not in trachea.
  • Primary malignant tracheal tumours consist mainly of squamous cell carcinoma and adenoid cystic carcinoma and generally have an aggressive course with poor prognosis.
  • We report the first presentation of a spindle cell sarcomatoid carcinoma of trachea together with the clinical course of the patient.
  • [MeSH-major] Carcinoma / pathology. Tracheal Neoplasms / pathology

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  • (PMID = 19787474.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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36. Lui PC, Fan YS, Lau PP, Chau TK, Tang VW, Tse GM, Yu AM, Vong JS, Tan PH, Trendell-Smith NJ: Vulvar basal cell carcinoma in China: a 13-year review. Am J Obstet Gynecol; 2009 May;200(5):514.e1-5
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  • [Title] Vulvar basal cell carcinoma in China: a 13-year review.
  • OBJECTIVE: We conducted a 12-year retrospective review of vulvar basal cell carcinoma (BCC) in a Chinese population.
  • The predominant histologic pattern was nodular, which may be mistaken as adenoid cystic carcinoma.
  • Formal histopathologic assessment should be used to reach an objective diagnosis.
  • [MeSH-major] Carcinoma, Basal Cell / ethnology. Carcinoma, Basal Cell / pathology. Vulvar Neoplasms / ethnology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Asian Continental Ancestry Group / statistics & numerical data. Biopsy. Female. Frozen Sections. Hong Kong / epidemiology. Humans. Incidence. Middle Aged. Retrospective Studies. Skin Neoplasms / ethnology. Skin Neoplasms / pathology. Skin Pigmentation

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  • (PMID = 19200934.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Fukuda M, Fukuda F, Horiuchi Y, Oku Y, Suzuki S, Kusama K, Sakashita H: Expression of CYLD, NF-kappaB and NF-kappaB-related factors in salivary gland tumors. In Vivo; 2006 Jul-Aug;20(4):467-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The cylindromatosis (CYLD) gene was originally identified as a tumor suppressor that is mutated in familial cylindromatosis, an autosomal dominant condition that confers a predisposition to multiple tumors of the skin appendages.
  • Adenoid cystic carcinoma (ACC) is a well known and typical malignant SGT ACC was previously known as cylindroma in view of its marked histological resemblance to dermal cylindroma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. NF-kappa B / metabolism. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 16900776.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / NF-kappa B; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; 0 / Tumor Suppressor Proteins; 0 / Ubiquitin; EC 2.7.11.10 / I-kappa B Kinase
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38. Fukuda M, Hiroi M, Suzuki S, Ohmori Y, Sakashita H: Loss of CYLD might be associated with development of salivary gland tumors. Oncol Rep; 2008 Jun;19(6):1421-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Molecular studies of cylindromas, which arise from the eccrine or apocrine cells of the skin, have demonstrated frequent alterations at chromosome 16q12-13, recently found to house the cylindromatosis (CYLD) gene.
  • We demonstrated previously that human salivary gland tumor (SGT) cell line, HSG spontaneously expresses CYLD and also found that adenoid cystic carcinoma (ACC) arising from the hard palate was distinctly positive for CYLD, immunohistochemically.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Genes, Tumor Suppressor / physiology. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 18497946.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / NF-kappa B; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Transcription Factor RelA; 0 / Tumor Necrosis Factor-alpha; 0 / Tumor Suppressor Proteins; EC 2.7.11.10 / I-kappa B Kinase
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39. Kazakov DV, Benkova K, Michal M, Vanecek T, Kacerovska D, Skalova A: Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. Hum Pathol; 2009 Oct;40(10):1499-503

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene.
  • It appears identical to cutaneous cylindroma, hence the synonym dermal analogue tumor.
  • We present a case of a tumor involving the parotid gland that appeared identical to cutaneous spiradenoma.
  • In addition, the lesion had a malignant component identical to basal cell adenocarcinoma.
  • This is the first report of a "dermal analogue tumor" of the salivary gland that resembled a cutaneous spiradenoma and not a cylindroma.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Parotid Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 19454360.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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40. Whatley WS, Thompson JW, Rao B: Salivary gland tumors in survivors of childhood cancer. Otolaryngol Head Neck Surg; 2006 Mar;134(3):385-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: There is an increased incidence of second malignant neoplasms in survivors of childhood cancers.
  • The most common second malignancies are acute leukemia, bone and soft tissue tumors, and carcinoma of the skin, breast, and thyroid.
  • The pathology of the salivary gland tumors were mucoepidermoid carcinoma (10), adenoid cystic carcinoma (1) , and pleomorphic adenoma (1).
  • All patients were treated with surgical excision of the primary tumor, and postoperative radiation was added in select patients.
  • The majority of these neoplasms are malignant; mucoepidermoid carcinoma occurs most frequently.
  • The treatment of these tumors includes surgical excision of the primary, with neck dissection in patients with clinical evidence of nodal metastasis, and postoperative radiation added for pathologies with adverse features.
  • [MeSH-major] Neoplasms, Second Primary / diagnosis. Salivary Gland Neoplasms / diagnosis. Survivors
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / surgery. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis / diagnosis. Male. Neck Dissection. Neoplasms / drug therapy. Neoplasms / radiotherapy. Radiotherapy, Adjuvant. Registries. Retrospective Studies. Risk Factors


41. Maruya SI, Myers JN, Weber RS, Rosenthal DI, Lotan R, El-Naggar AK: ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion! Oral Oncol; 2005 Jul;41(6):580-8
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  • [Title] ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion!
  • To determine the association of this gene in tumorigenesis and perineural invasion, we analyzed the expression and functional status of ICAM-5 mRNA transcripts in 30 different human cancer cell lines and 25 head and neck squamous carcinoma specimens by reverse-transcriptase polymerase chain reaction (cell lines and specimens) and in vitro functional assays (cell lines).
  • ICAM-5 transcripts were detected in 28 (93%) of 30 cell lines derived from primary head and neck, colon, thyroid, cervical, pancreatic, skin, and adenoid cystic carcinomas.
  • In tissue specimens, none of the 25 histologically normal oral mucosal specimens had detectable ICAM-5 level, whereas 16 (64%) of the 25 matched primary squamous carcinomas showed expression.
  • Carcinoma specimens high ICAM-5 expression had a high incidence of perineural invasion.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Head and Neck Neoplasms / metabolism. Membrane Glycoproteins / metabolism. Neoplasm Proteins / metabolism. Nerve Tissue Proteins / metabolism

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  • (PMID = 15975520.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / Chromones; 0 / Enzyme Inhibitors; 0 / ICAM5 protein, human; 0 / Membrane Glycoproteins; 0 / Morpholines; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / RNA, Small Interfering; 154447-36-6 / 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; EC 2.7.1.- / Phosphatidylinositol 3-Kinases
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42. Fernandez-Flores A, Pol A, Juanes F, Crespo LG: Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies. Med Mol Morphol; 2007 Dec;40(4):212-7
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  • [Title] Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies.
  • We report a cribriform carcinoma of the left fossa poplitea in a 62-year-old woman.
  • The patient did not present any symptoms, and the only complaint was the nodule, which was resected for diagnosis.
  • After considering different diagnostic options, we decided that the most appropriate one was cribriform carcinoma, which is an entity described in 1998.
  • The diagnostic criteria, which were provided in the few publications that refer to this entity, helped us to distinguish it from the main mimicker: cystic adenoid carcinoma.
  • [MeSH-major] Adenocarcinoma / immunology. Adenocarcinoma / pathology. Antibodies, Neoplasm / immunology. Skin Neoplasms / immunology. Skin Neoplasms / pathology

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  • (PMID = 18085381.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm
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43. Juhlin J: [Surgery on cylindroma of the external auditory canal]. Ugeskr Laeger; 2009 Nov 2;171(45):3280-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cylindromas are rare benign tumours arising from sweat glands in the skin.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Ear Canal / surgery. Ear Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Otologic Surgical Procedures / methods. Skin Neoplasms / surgery

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  • (PMID = 19887058.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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44. Oosterkamp HM, Neering H, Nijman SM, Dirac AM, Mooi WJ, Bernards R, Brummelkamp TR: An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis. Br J Dermatol; 2006 Jul;155(1):182-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Familial cylindromatosis is a rare genetic disorder, giving rise to neoplasms of the skin appendages.
  • [MeSH-major] Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Skin Appendage / drug therapy. Keratolytic Agents / administration & dosage. Neoplastic Syndromes, Hereditary / drug therapy. Salicylic Acid / administration & dosage

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  • (PMID = 16792771.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratolytic Agents; 0 / NF-kappa B; EC 2.7.11.10 / I-kappa B Kinase; O414PZ4LPZ / Salicylic Acid
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45. Bowen S, Gill M, Lee DA, Fisher G, Geronemus RG, Vazquez ME, Celebi JT: Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation. J Invest Dermatol; 2005 May;124(5):919-20
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  • Patients with BSS are predisposed to multiple skin appendage tumors such as cylindroma, trichoepithelioma, and spiradenoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Skin Appendage / genetics. Mutation. Neoplasms, Multiple Primary / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics


46. Locati LD, Bossi P, Perrone F, Potepan P, Crippa F, Mariani L, Casieri P, Orsenigo M, Losa M, Bergamini C, Liberatoscioli C, Quattrone P, Calderone RG, Rinaldi G, Pilotti S, Licitra L: Cetuximab in recurrent and/or metastatic salivary gland carcinomas: A phase II study. Oral Oncol; 2009 Jul;45(7):574-8
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  • From April to December 2005, 30 patients [23 adenoid cystic carcinoma (ACC) and 7 non-ACC] were treated with cetuximab at 400mg/m(2)/week followed by 250mg/m(2)/week until progression, major toxicity or voluntary discontinuation.
  • Skin toxicity was the main adverse event.
  • Skin rash >or=G2, EGFR overexpression and EGFR copy number were not statistically correlated to CB.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Neoplasm Recurrence, Local / drug therapy. Salivary Gland Neoplasms / drug therapy

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  • (PMID = 18804410.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; PQX0D8J21J / Cetuximab
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47. Novo-Torres A, Laredo-Ortiz C, Castellar-Nájera E, Lorda-Barraguer E, Alenda-González C: [Familial presentation of multiple scalp tumors]. Actas Dermosifiliogr; 2007 Mar;98(2):109-11
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  • The tumors were excised and the histological findings confirmed the diagnosis of cylindromas.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Head and Neck Neoplasms / genetics. Neoplasms, Multiple Primary / genetics. Neoplastic Syndromes, Hereditary / genetics. Scalp / pathology. Skin Neoplasms / genetics
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Skin Transplantation

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  • (PMID = 17397598.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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48. Kazakov DV, Zelger B, Rütten A, Vazmitel M, Spagnolo DV, Kacerovska D, Vanecek T, Grossmann P, Sima R, Grayson W, Calonje E, Koren J, Mukensnabl P, Danis D, Michal M: Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol; 2009 May;33(5):705-19
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  • [Title] Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome.
  • The authors present a series of 24 malignant neoplasms arising in preexisting benign spiradenoma (20), cylindroma (2), and spiradenocylindroma (2).
  • Nineteen patients (12 females, 7 males; age range, 41 to 92 y) had a solitary neoplasm (size range, 2.2 to 17.5 cm; median 4 cm), whereas the remaining 5 (4 females, 1 male; age range, 66 to 72 y) manifested clinical features of Brooke-Spiegler syndrome (BSS), an autosomal dominantly inherited disease characterized by widespread, small, benign neoplasms on which background larger malignant lesions appeared.
  • The malignant components of the lesions were variable and could be classified into 4 main patterns, occurring alone or in combination:.
  • 3) invasive adenocarcinoma, not otherwise specified (IAC-NOS); and 4) sarcomatoid (metaplastic) carcinoma.
  • Cases harboring a sarcomatoid carcinoma featured a malignant epithelial component composed of varying combinations of BCAC-HG, BCAC-LG, IAC-NOS, or squamous cell carcinoma, whereas the sarcomatoid component appeared as either a pleomorphic or spindle-cell sarcoma.
  • Additionally, in 2 cases there were foci of heterologous chondrosarcomatous differentiation and in 1 case there was rhabomyosarcomatous differentiation.
  • The histologic pattern of the malignant neoplasm correlated to some extent with the clinical course.
  • Patients with sarcomatoid carcinoma had a relatively good survival.
  • Given the morphologic diversity and complexity of the neoplasms in question, we propose using a more specific terminology with the precise description of the neoplasm components, rather than generic and less informative terms such as "spiradenocarcinoma" or "carcinoma ex cylindroma. "
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Australia. Carcinoma, Skin Appendage / pathology. Carcinoma, Squamous Cell / pathology. Cell Differentiation. Chromosomes, Human, Pair 16. Europe. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Metaplasia. Middle Aged. Mutation. Neoplasm Invasiveness. South Africa. Syndrome. Treatment Outcome. Tumor Suppressor Proteins / genetics

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  • (PMID = 19194280.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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49. Parren LJ, Bauer B, Hamm H, Frank J: Brooke-Spiegler syndrome complicated by unilateral hearing loss. Int J Dermatol; 2008 Nov;47 Suppl 1:56-9
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  • Brooke-Spiegler syndrome is an autosomal dominant tumor predisposition disorder.
  • The disease is characterized by the occurrence of multiple skin appendage tumors, including cylindroma, trichoepithelioma, and spiradenoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / complications. Carcinoma, Skin Appendage / complications. Ear Neoplasms / complications. Hearing Loss, Unilateral / etiology. Neoplasms, Multiple Primary / complications. Skin Neoplasms / complications

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  • (PMID = 18986490.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Kim C, Kovich OI, Dosik J: Brooke-Spiegler syndrome. Dermatol Online J; 2007;13(1):10
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  • A 46-year-old woman with Brooke-Spiegler syndrome has multiple cutaneous adnexal neoplasms on her face and scalp.
  • Etiology, clinical features, malignant transformation, and treatment modalities for Brooke-Spiegler syndrome are reviewed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Face. Female. Humans. Middle Aged. Scalp. Syndrome

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  • (PMID = 17511943.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Ricard AS, Laurentjoye M, Faucher A, Zwetyenga N, Siberchicot F, Majoufre-Lefebvre C: [276 cases of horizontal infrahyoid myocutaneous flap]. Rev Stomatol Chir Maxillofac; 2009 Jun;110(3):135-7
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  • The horizontal design of the skin paddle is a modification of this technique allowing for a smaller scar.
  • DISCUSSION: Modifying the infrahyoid myocutaneous flap technique with a horizontal design of the skin paddle does not modify the reliability of the flap and prevents more extensive scars.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Neck Muscles / transplantation. Skin Transplantation / methods. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / surgery. Cicatrix / prevention & control. Female. Gingival Neoplasms / surgery. Graft Survival. Humans. Male. Middle Aged. Mouth Floor / surgery. Mouth Neoplasms / surgery. Oropharyngeal Neoplasms / surgery. Postoperative Complications. Reconstructive Surgical Procedures / methods. Retrospective Studies. Tongue Neoplasms / surgery. Treatment Outcome. Venous Insufficiency / etiology

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  • (PMID = 19403148.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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52. Friedrich RE: Dermal cylindroma of the scalp (turban tumour) and subjacent calvarian defects. Anticancer Res; 2010 May;30(5):1793-7
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  • This case report describes the diagnosis and therapy of a patient with a 40-year history of multiple potato-like tumours growing in the head and neck region.
  • Complete work-up of the resection specimen excluded any malignant transformation of the tumour.
  • A long lasting history of cylindroma and evidence for bone destruction, not associated with a malignant transformation, is extremely rare in Brooke-Spiegler's syndrome.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / pathology. Scalp / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Angiography / methods. Biopsy. Carotid Arteries / pathology. Female. Humans. Magnetic Resonance Imaging / methods. Skin / pathology. Syndrome. Treatment Outcome

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  • (PMID = 20592381.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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53. Doherty SD, Barrett TL, Joseph AK: Brooke-Spiegler syndrome: report of a case of multiple cylindromas and trichoepitheliomas. Dermatol Online J; 2008;14(7):8
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  • We report a case of Brooke-Spiegler syndrome, a rare autosomal dominant disorder caused by mutations of the cylindromatosis gene (CYLD) tumor suppressor gene resulting in multiple cylindromas and trichoepitheliomas.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Skin Appendage / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 18718192.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins; R16CO5Y76E / Aspirin
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54. Wang Y, Feng GS, Tian H, Zhang ZH, Xiong T: [Fluorescent imaging of angiogenesis and spontaneous metastasis in transplanted hepatoma: experiment with mice]. Zhonghua Yi Xue Za Zhi; 2007 Dec 11;87(46):3307-9
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  • OBJECTIVE: To establish stable enhanced green fluorescent protein (GFP) -expressing human adenoid cystic carcinoma (ACC-M-GFP) cell lines with high lung metastatic potential, and to study the value and influential factor of in vivo monitoring of metastasis and angiogenesis by fluorescent imaging.
  • METHODS: Human adenoid cystic carcinoma cell line ACC-M-GFP labeled with enhanced GFP was established.
  • Once the subcutaneous tumor reached 0.5 cm in diameter, it was removed, cut into 1 mm3 pieces, and implanted into the left hepatic lobe of 8 nude mice.
  • By whole-body optical system, the fluorescent signal from the liver tumor was detected through a skin-flap window after 6 - 8 weeks.
  • Tumors were visualized directly through skin after 8 - 10 weeks.
  • [MeSH-minor] Animals. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cell Line, Tumor. Green Fluorescent Proteins / genetics. Green Fluorescent Proteins / metabolism. Humans. Mice. Mice, Inbred BALB C. Mice, Nude. Microscopy, Fluorescence. Transplantation, Heterologous

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  • (PMID = 18396632.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 147336-22-9 / Green Fluorescent Proteins
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55. Aneiros-Fernandez J, Husein-ElAhmed H, Arias-Santiago S, Nicolae A, O'Valle-Ravassa F: Unknown: A woman with an erythematous nodule on the scalp. Dermatol Online J; 2010;16(4):12
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  • The rest of her cutaneous exam was normal.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Head and Neck Neoplasms / diagnosis. Scalp. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Telangiectasis / diagnosis. Telangiectasis / pathology. Telangiectasis / surgery

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  • (PMID = 20409419.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Tauriello DV, Haegebarth A, Kuper I, Edelmann MJ, Henraat M, Canninga-van Dijk MR, Kessler BM, Clevers H, Maurice MM: Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell; 2010 Mar 12;37(5):607-19
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  • Moreover, we demonstrate hyperactive Wnt signaling in human cylindroma skin tumors that arise from mutations in CYLD.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Skin Appendage / metabolism. Phosphoproteins / metabolism. Protein Processing, Post-Translational. Signal Transduction. Skin Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism. Wnt Proteins / metabolism. beta Catenin / metabolism


57. Zhang G, Huang Y, Yan K, Li W, Fan X, Liang Y, Sun L, Li H, Zhang S, Gao M, Du W, Yang S, Liu J, Zhang X: Diverse phenotype of Brooke-Spiegler syndrome associated with a nonsense mutation in the CYLD tumor suppressor gene. Exp Dermatol; 2006 Dec;15(12):966-70
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  • Clinically, some affected individuals only revealed discrete small skin-coloured tumors whereas the proband showed an expansion of multiple large tumors on the back of nose and numerous dome-shaped papules on her scalp.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Skin Appendage / genetics. Codon, Nonsense. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adult. China. DNA Mutational Analysis. Family Health. Female. Humans. Male. Neoplasms, Multiple Primary / genetics. Neoplasms, Multiple Primary / pathology. Pedigree. Phenotype

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  • (PMID = 17083363.001).
  • [ISSN] 0906-6705
  • [Journal-full-title] Experimental dermatology
  • [ISO-abbreviation] Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Codon, Nonsense; 0 / Tumor Suppressor Proteins
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58. Maillard GF, Garey L: Plastic surgery after ablative cancer surgery. Aesthetic Plast Surg; 2006 Jan-Feb;30(1):47-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Humans. Lip Neoplasms / pathology. Lip Neoplasms / surgery. Nose Neoplasms / pathology. Nose Neoplasms / surgery. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery. Scalp. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Surgical Flaps

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  • (PMID = 16402163.001).
  • [ISSN] 0364-216X
  • [Journal-full-title] Aesthetic plastic surgery
  • [ISO-abbreviation] Aesthetic Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Crain N, Nelson BL, Barnes EL, Thompson LD: Ceruminous gland carcinomas: a clinicopathologic and immunophenotypic study of 17 cases. Head Neck Pathol; 2009 Mar;3(1):1-17

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  • BACKGROUND: Ceruminal gland carcinomas are rare neoplasms confined to the skin lining the cartilaginous part of the external auditory canal.
  • Histologically, the tumors demonstrated a solid to cystic pattern, composed of an infiltrating glandular to cribriform arrangement of epithelial cells.
  • Tumors were divided into three types of adenocarcinoma based on pattern of growth and cell type (ceruminous, NOS [n = 12], adenoid cystic [n = 4], mucoepidermoid [n = 1]).
  • CK7 and CD117 highlighted the luminal cells, while S1-00 protein showed a predilection for the basal cells of ceruminous and adenoid cystic carcinomas.
  • CONCLUSION: Ceruminous-type carcinomas, with the exception of ceruminous mucoepidermoid carcinoma, all demonstrated a dual cell population of basal myoepithelial-type cells and luminal apocrine cells.
  • [MeSH-major] Carcinoma / pathology. Ear Neoplasms / pathology. Ear, External / pathology

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  • (PMID = 20596983.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807538
  • [Keywords] NOTNLM ; Adenoid cystic / Carcinoma / Ceruminal / Ceruminous / Ear / Gland / Immunohistochemistry / Mucoepidermoid / Prognosis
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60. Massoumi R, Paus R: Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control. Bioessays; 2007 Dec;29(12):1203-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Analysing cylindromatosis and the associated defects in the CYLD gene is providing novel insights into the molecular principles of epithelial growth control and carcinogenesis in, and beyond, the skin.
  • In this review, we summarize the histopathology and histogenesis of cylindromas, and the available genetic information on patients with these skin appendage tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Epithelium / pathology. Tumor Suppressor Proteins / genetics

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  • [Copyright] 2007 Wiley Periodicals, Inc
  • (PMID = 18008375.001).
  • [ISSN] 0265-9247
  • [Journal-full-title] BioEssays : news and reviews in molecular, cellular and developmental biology
  • [ISO-abbreviation] Bioessays
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / NF-kappa B; 0 / Tumor Suppressor Proteins; 0 / Ubiquitin
  • [Number-of-references] 76
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61. Cernea CR, Dias FL, Lima RA, Farias T, Mendonça UB, Vellutini E, Gomes MQ, Nogueira J, Lorencetti RR, Brandão LG, Dos Santos LR, Morais-Besteiro J, Ishida LC, Galvão MS: Atypical facial access: an unusually high prevalence of use among patients with skull base tumors treated at 2 centers. Arch Otolaryngol Head Neck Surg; 2007 Aug;133(8):816-9
MedlinePlus Health Information. consumer health - Skin Cancer.

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  • OBJECTIVE: To analyze the influence of the unique percentage of skin carcinomas with skull base invasion on the choice of the facial surgical approach.
  • Data were collected on demographic distribution, location of the primary tumor, histologic type, type of operation, reconstruction, complications, and outcome.
  • The initial location of the tumor was the craniofacial skin in 63.5% of cases, ethmoid in 10.8%, maxilla in 2.3%, orbit in 1.9%, and other origins, including endocranial, in 19.4%.
  • The histologic type of the lesions was basal cell carcinoma in 42.0% of cases, squamous cell carcinoma in 29.5%, esthesioneuroblastoma in 5.3%, adenocarcinoma in 3.9%, adenoid cystic carcinoma in 2.8%, and other types in 16.5%.
  • Owing to this high prevalence of advanced skin carcinomas, the most commonly employed facial approach was atypical, tailored to encompass all compromised skin and underlying tissues, in 55.5% of cases, followed by the Weber-Ferguson approach, with all its variations (eg, nasal swing) in 17.8%, lateral rhinotomy in 12.2%, facial translocation in 3.8%, and other facial techniques in 7.7%.
  • CONCLUSION: In most situations, head and neck surgeons chose an atypical surgical approach to properly resect all facial structures invaded by very advanced skin cancers.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Face / surgery. Neurosurgical Procedures / methods. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery. Skull Base Neoplasms / surgery

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  • (PMID = 17709623.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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62. Retamar RA, Stengel F, Saadi ME, Kien MC, Della Giovana P, Cabrera H, Chouela EN: Brooke-Spiegler syndrome - report of four families: treatment with CO2 laser. Int J Dermatol; 2007 Jun;46(6):583-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Brooke-Spiegler syndrome is a well known but rare cutaneous disorder characterized by the presence of multiple trichoepitheliomas and cylindromas.
  • [MeSH-major] Adenoma, Sweat Gland / surgery. Carcinoma, Adenoid Cystic / surgery. Laser Therapy. Neoplasms, Adnexal and Skin Appendage / surgery. Neoplasms, Multiple Primary / surgery. Neoplastic Syndromes, Hereditary / surgery. Skin Neoplasms / surgery

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  • (PMID = 17550556.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Komander D: CYLD tidies up dishevelled signaling. Mol Cell; 2010 Mar 12;37(5):589-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / metabolism. Carcinoma, Adenoid Cystic / metabolism. Phosphoproteins / metabolism. Protein Processing, Post-Translational. Signal Transduction. Skin Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism. Wnt Proteins / metabolism. beta Catenin / metabolism

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  • [Copyright] (c) 2010 Elsevier Inc. All rights reserved.
  • [CommentOn] Mol Cell. 2010 Mar 12;37(5):607-19 [20227366.001]
  • (PMID = 20227361.001).
  • [ISSN] 1097-4164
  • [Journal-full-title] Molecular cell
  • [ISO-abbreviation] Mol. Cell
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U105192732
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / CTNNB1 protein, human; 0 / CYLD protein, human; 0 / Phosphoproteins; 0 / Tumor Suppressor Proteins; 0 / Wnt Proteins; 0 / Wnt3 Protein; 0 / beta Catenin; 0 / dishevelled proteins; K3Z4F929H6 / Lysine
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64. Scalvenzi M, Francia MG, Falleti J, Balato A: Basal cell carcinoma with fibroepithelioma-like histology in a healthy child: report and review of the literature. Pediatr Dermatol; 2008 May-Jun;25(3):359-63
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma with fibroepithelioma-like histology in a healthy child: report and review of the literature.
  • In 2003 a dermoscopic examination was executed and a diagnosis of dermical nevus was made.
  • A diagnosis of basal cell carcinoma was made and confirmed by histopathologic examination.
  • The histopathologic specimen showed nests or lobules of basalioid cells associated with a surrounding loose fibromucinous stroma; two patterns were observed: adenoid-cystic and fibroepithelial.
  • Basal cell carcinoma occurs rarely in children and is most often associated with an underlying condition that predisposes patients to the development of malignancy that was not present in our case.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Dermoscopy. Diagnosis, Differential. Female. Humans

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  • (PMID = 18577044.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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65. Kazakov DV, Thoma-Uszynski S, Vanecek T, Kacerovska D, Grossmann P, Michal M: A case of Brooke-Spiegler syndrome with a novel germline deep intronic mutation in the CYLD gene leading to intronic exonization, diverse somatic mutations, and unusual histology. Am J Dermatopathol; 2009 Oct;31(7):664-73
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Additionally, we microscopically studied a spiradenocylindroma that showed unusual histology, including foci of follicular differentiation.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / genetics. Skin Neoplasms / pathology. Tumor Suppressor Proteins / genetics

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  • (PMID = 19668078.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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66. Scholz IM, Nümann A, Froster UG, Helmbold P, Enk AH, Näher H: New mutation in the CYLD gene within a family with Brooke-Spiegler syndrome. J Dtsch Dermatol Ges; 2010 Feb;8(2):99-101
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  • Brooke-Spiegler syndrome is a rare, autosomal dominant disease characterized by multiple skin appendage tumors caused by various mutations in the CYLD gene on chromosome 16q12-q13.
  • In addition, there may be malignant transformation of the generally benign tumors, so that a timely diagnosis is essential for appropriate monitoring and therapy.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. DNA Mutational Analysis. Facial Neoplasms / genetics. Frameshift Mutation. Neoplasms, Multiple Primary / genetics. Scalp. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adenoma, Sweat Gland / diagnosis. Adenoma, Sweat Gland / genetics. Adenoma, Sweat Gland / pathology. Adolescent. Adult. Biopsy. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / genetics. Carcinoma, Basal Cell / pathology. Chromosome Aberrations. Chromosomes, Human, Pair 16 / genetics. Exons / genetics. Female. Genes, Dominant / genetics. Humans. Male. Middle Aged. Nose Neoplasms / genetics. Nose Neoplasms / pathology. Phenotype. Skin / pathology. Syndrome

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  • (PMID = 20151946.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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67. Darling MR, Tsai S, Jackson-Boeters L, Daley TD, Diamandis EP: Human kallikrein 8 expression in salivary gland tumors. Head Neck Pathol; 2008 Sep;2(3):169-74
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  • The human kallikrein 8 protein (KLK8) is expressed in many normal tissues including esophagus, skin, testis, tonsil, kidney, breast, and salivary gland, and is found in biological fluids including breast milk, amniotic fluid, seminal fluid and serum.
  • The aim of this study was to determine whether KLK8 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas, and adenocarcinomas NOS of both minor and major salivary glands were examined.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Humans. Immunoenzyme Techniques

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  • (PMID = 20614312.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.- / KLK8 protein, human; EC 3.4.21.- / Kallikreins
  • [Other-IDs] NLM/ PMC2807567
  • [Keywords] NOTNLM ; Human kallikrein 8 / Immunohistochemistry / Kallikreins / Prognostic markers / Salivary gland tumors
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68. Musani MA, Sohail Z, Zafar S, Malik S: Morphological pattern of parotid gland tumours. J Coll Physicians Surg Pak; 2008 May;18(5):274-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Out of 204 cases, 152 (74.5%) were benign and 52 (25.5%) were malignant.
  • Benign tumours were more common in females whereas malignant tumours were common in males.
  • The mean age of patients was 34 years and 42 years for benign and malignant tumours respectively.
  • The most common malignant tumour was mucoepidermoid carcinoma (60%), followed by adenoid cystic carcinoma.
  • Superficial lobe of parotid gland was the commonest site, 120 benign and all 52 malignant tumours arising from it while 32 benign tumours originated from deep lobe.
  • Parotid swelling for years was main feature of benign tumours, whereas malignant tumours presented with pain, fixation to skin or underlying structure, cervical lymphadenopathy and facial palsy.
  • CONCLUSION: Pleomorphic adenoma was the most common benign tumour and mucoepidermoid carcinoma was most common malignant tumour.
  • [MeSH-major] Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Fine-Needle. Child. Diagnosis, Differential. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Morbidity / trends. Neoplasm Staging / methods. Pakistan / epidemiology. Retrospective Studies. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 18541080.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Pakistan
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69. Tsujii H, Mizoe J, Kamada T, Baba M, Tsuji H, Kato H, Kato S, Yamada S, Yasuda S, Ohno T, Yanagi T, Imai R, Kagei K, Kato H, Hara R, Hasegawa A, Nakajima M, Sugane N, Tamaki N, Takagi R, Kandatsu S, Yoshikawa K, Kishimoto R, Miyamoto T: Clinical Results of Carbon Ion Radiotherapy at NIRS. J Radiat Res; 2007;48 Suppl A:A1-A13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The RBE of carbon ions was estimated to be 2.0 to 3.0 along the SOBP for acute skin reactions.
  • Tumors that appear to respond favorably to carbon ions include locally advanced tumors and those with histologically non-squamous cell type of tumors such as adenocarcinoma, adenoid cystic carcinoma, malignant melanoma, hepatoma, and bone/soft tissue sarcoma.
  • [MeSH-minor] Carbon / therapeutic use. Carcinoma, Hepatocellular. Humans. Liver Neoplasms / radiotherapy. Neoplasms / radiotherapy

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  • (PMID = 17513896.001).
  • [ISSN] 1349-9157
  • [Journal-full-title] Journal of radiation research
  • [ISO-abbreviation] J. Radiat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 7440-44-0 / Carbon
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70. Wickström SA, Masoumi KC, Khochbin S, Fässler R, Massoumi R: CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J; 2010 Jan 6;29(1):131-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis.
  • [MeSH-minor] Acetylation. Animals. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Catalytic Domain. Cell Line, Tumor. Cytokinesis. Genes, Tumor Suppressor. Humans. Keratinocytes / cytology. Keratinocytes / drug effects. Keratinocytes / metabolism. Melanocytes / cytology. Melanocytes / drug effects. Melanocytes / metabolism. Melanoma / genetics. Melanoma / metabolism. Melanoma / pathology. Mice. Microtubules / metabolism. Mutation. Recombinant Fusion Proteins / genetics. Recombinant Fusion Proteins / metabolism. Skin Neoplasms / genetics. Skin Neoplasms / metabolism. Skin Neoplasms / pathology. Tetradecanoylphorbol Acetate / pharmacology


71. Mataix J, Bañuls J, Botella R, Laredo C, Lucas A: [Brooke-Spiegler syndrome: an heterogeneous entity]. Actas Dermosifiliogr; 2006 Dec;97(10):669-72
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Neoplasms, Basal Cell / genetics. Neoplasms, Multiple Primary / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adult. Child. Facial Neoplasms / diagnosis. Facial Neoplasms / genetics. Female. Genes, Dominant. Humans. Phenotype

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  • (PMID = 17173833.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 30
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72. Bidros RS, Metzinger SE, Guerra AB: The thoracodorsal artery perforator-scapular osteocutaneous (TDAP-SOC) flap for reconstruction of palatal and maxillary defects. Ann Plast Surg; 2005 Jan;54(1):59-65
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  • The skin paddle received its blood supply from the major perforating vessels of the thoracodorsal artery, and the scapular bone was nourished by the angular vessels.
  • [MeSH-minor] Adolescent. Adult. Carcinoma, Adenoid Cystic / surgery. Humans. Jaw Neoplasms / surgery. Male. Maxilla / surgery. Palate / surgery. Sarcoma / surgery

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  • (PMID = 15613885.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Kuklani RM, Glavin FL, Bhattacharyya I: Malignant cylindroma of the scalp arising in a setting of multiple cylindromatosis: a case report. Head Neck Pathol; 2009 Dec;3(4):315-9
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  • [Title] Malignant cylindroma of the scalp arising in a setting of multiple cylindromatosis: a case report.
  • An unusual case of malignant cylindroma of the scalp arising in a 79-year-old white female with multiple cylindromatosis is presented.
  • Multiple cylindromatosis is an uncommon hereditary autosomal dominant disease, which is characterized by multiple skin adnexal tumors like cylindromas and trichoepitheliomas and occasional spiradenomas.
  • Cylindroma is an uncommon benign tumor, which originates from skin appendages and is most commonly found on the scalp and face with a strong predilection for middle-aged and elderly females.
  • Although cylindromas are usually benign neoplasms, carcinoma arising in such neoplasms is rare with only sporadic reports in literature.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 20596852.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2811564
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74. Kazakov DV, Soukup R, Mukensnabl P, Boudova L, Michal M: Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):27-33
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  • [Title] Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation.
  • Brooke-Spiegler syndrome is an autosomal dominantly inherited disease with predisposition to cutaneous adnexal neoplasms, most commonly cylindromas and trichoepitheliomas.
  • The histopathological survey revealed a plethora of benign adnexal neoplasms showing apocrine, follicular, and sebaceous differentiation occurring independently and conjointly.
  • Some spiradenocylindromas demonstrated prominent sebaceous or trichoblastomatous differentiation or both.
  • The occurrence of sebaceous and trichoblastic differentiation in spiradenocylindromas is a further proof that spiradenoma and cylindroma are not eccrine tumors but neoplasms of the folliculosebaceousapocrine unit.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hair Diseases / metabolism. Hair Diseases / pathology. Hair Diseases / surgery. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Immunoenzyme Techniques. Male. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Syndrome

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  • (PMID = 15677973.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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75. Rajan N, Langtry JA, Ashworth A, Roberts C, Chapman P, Burn J, Trainer AH: Tumor mapping in 2 large multigenerational families with CYLD mutations: implications for disease management and tumor induction. Arch Dermatol; 2009 Nov;145(11):1277-84
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  • Differentiation between the clinical diagnoses has little prognostic or clinical utility in genetic counseling, even within individuals from the same family.
  • Thus, we suggest an encompassing diagnosis of "CYLD cutaneous syndrome."

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  • (PMID = 19917957.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] ENG
  • [Grant] United Kingdom / Cancer Research UK / / A8363; United Kingdom / Medical Research Council / / G0701367; United Kingdom / Medical Research Council / / G0701367(84978); United Kingdom / Cancer Research UK / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
  • [Other-IDs] NLM/ PMC2935681; NLM/ UKMS31751
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76. Jereczek-Fossa BA, Krengli M, Orecchia R: Particle beam radiotherapy for head and neck tumors: radiobiological basis and clinical experience. Head Neck; 2006 Aug;28(8):750-60
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  • It is now well accepted that there are certain indications for using proton therapy for skull base tumors (chordoma and chondrosarcoma), paranasal sinus carcinomas, selected nasopharyngeal tumors, and neutron/ion therapy for salivary gland carcinomas (in particular, adenoid cystic tumors).
  • Its viability in other cases, such as locally advanced squamous cell carcinoma, melanoma, soft tissue sarcoma, and bone sarcoma, is still under investigation.
  • [MeSH-minor] Chordoma / radiotherapy. Humans. Melanoma / radiotherapy. Nose Neoplasms / radiotherapy. Pharyngeal Neoplasms / radiotherapy. Radiobiology. Radiotherapy Dosage. Salivary Gland Neoplasms / radiotherapy. Skin Neoplasms / radiotherapy. Skull Base Neoplasms / radiotherapy

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  • (PMID = 16804876.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 80
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77. Carlson RM, Haddad L, Pui JC: Brooke-Spiegler syndrome with associated pegged teeth. Cutis; 2008 Nov;82(5):345-9
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  • This combination represents a rare genetic syndrome with tumors expressing adnexal differentiation.
  • Malignant transformation is rare but reported, and surgical excision is warranted to prevent turban tumor formation of the scalp.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / physiopathology. Skin Neoplasms / physiopathology. Tooth Abnormalities / etiology
  • [MeSH-minor] Adult. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / physiopathology. Female. Genetic Testing. Humans. Mutation. Neoplastic Syndromes, Hereditary / diagnosis. Neoplastic Syndromes, Hereditary / genetics. Neoplastic Syndromes, Hereditary / physiopathology. Syndrome. Tumor Suppressor Proteins / genetics

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  • (PMID = 19090338.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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78. Miettinen M, Lasota J: KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol; 2005 Sep;13(3):205-20

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  • Such activation regulates apoptosis, cell differentiation, proliferation, chemotaxis, and cell adhesion.
  • Other KIT-positive normal cells include epithelial cells in skin adnexa, breast, and subsets of cerebellar neurons.
  • Also, KIT is expressed in pulmonary and other small cell carcinomas, adenoid cystic carcinoma, renal chromophobe carcinoma, thymic, and some ovarian and few breast carcinomas.
  • KIT deficiency due to hereditary nonsense/missense mutations leads to disruption of KIT-dependent functions such as erythropoiesis, skin pigmentation, fertility, and gastrointestinal motility.
  • KIT tyrosine kinase inhibitors such as imatinib mesylate are the generally accepted treatment of metastatic GISTs, and their availability has prompted an active search for other treatment targets among KIT-positive tumors such as myeloid leukemias and small cell carcinoma of the lung, with variable and often nonconvincing results.

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  • (PMID = 16082245.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 239
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79. Trepp R, Padberg BC, Varga Z, Cathomas R, Inauen R, Reinhart WH: Extensive extranodal metastases of basal-like breast cancer with predominant myoepithelial spindle cell differentiation. Pathol Res Pract; 2010 May 15;206(5):334-7
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  • [Title] Extensive extranodal metastases of basal-like breast cancer with predominant myoepithelial spindle cell differentiation.
  • A differentiation towards myoepithelial cells has been demonstrated in several types of lesions in the breast.
  • These include multifocal myoepitheliomatosis, the rare mixed tumor or pleomorphic adenoma, adenoid cystic carcinoma, adenomyoepithelioma and myoepithelial carcinoma (malignant myoepithelioma).
  • Myoepithelial carcinoma is the only lesion purely composed of myoepithelial cells.
  • All these tumors are benign and/or of low-grade malignancy, with the exception of malignant myoepithelioma.
  • The presented case of a breast carcinoma with dominant myoepithelial/spindle cell differentiation in a 58-year-old woman is an excellent example to document the highly aggressive biological behavior of this tumor phenotype.
  • Despite an extensive chemotherapy and radiotherapy, the tumor was rapidly progressive, forming a finally exulcerating local tumor relapse and widespread metastases to the myocardium, lungs, liver, kidneys and skin.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma / secondary. Kidney Neoplasms / secondary. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Skin Neoplasms / secondary


80. Kazakov DV, Schaller J, Vanecek T, Kacerovska D, Michal M: Brooke-Spiegler syndrome: report of a case with a novel mutation in the CYLD gene and different types of somatic mutations in benign and malignant tumors. J Cutan Pathol; 2010 Aug;37(8):886-90
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  • [Title] Brooke-Spiegler syndrome: report of a case with a novel mutation in the CYLD gene and different types of somatic mutations in benign and malignant tumors.
  • The available histopathological material included 24 trichoepitheliomas, 2 large nodular basal cell carcinomas (BCCs), 2 spiradenomas, 1 spiradenocylindroma and 1 trichoblastoma composed of large and small nodules with prominent clear cell differentiation.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Basal Cell / genetics. Carcinoma, Skin Appendage / genetics. Facial Neoplasms / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 20132422.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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81. Carlsten JR, Lewis MD, Saddler K, Reilly P, Pan T, Gnepp DR, Robinson-Bostom L: Spiradenocylindrocarcinoma: a malignant hybrid tumor. J Cutan Pathol; 2005 Feb;32(2):166-71
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  • [Title] Spiradenocylindrocarcinoma: a malignant hybrid tumor.
  • BACKGROUND: Eccrine spiradenomas and cylindromas are benign, slowly growing, cutaneous adnexal neoplasms, recently hypothesized to arise from a common pluripotential cell; malignant variants are rare.
  • We found 48 cases of malignant spiradenomas and 33 cases of malignant cylindromas reported in the English literature.
  • CASE REPORT: We describe two cases of a malignant variant of this rare hybrid tumor occurring in a 62-year-old male and a 72-year-old female.
  • CONCLUSION: We propose the term 'spiradenocylindrocarcinoma' to describe malignant tumors with features of both a spiradenoma and a cylindroma.
  • In conjunction with histological features of malignancy, p53 and Ki-67 immunohistochemical staining may provide helpful clues in determining the malignant potential of this tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [ErratumIn] J Cutan Pathol. 2005 Jul;32(6):453
  • (PMID = 15606677.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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82. Odashiro M, Lima MG, Miiji LN, Odashiro DN, Carvalho GV, Prates Campos JC, Odashiro AN: Infiltrating syringomatous adenoma of the nipple. Breast J; 2009 Jul-Aug;15(4):414-6
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  • Infiltrating syringomatous adenoma of the nipple is a rare, benign, locally invasive tumor with recurrence potential, showing sweat duct differentiation.
  • Histopathologically, it must be distinguished from florid papillomatosis, adenosquamous carcinoma, adenoid cystic carcinoma and sclerosing syringomatous carcinoma.
  • The skin was intact.

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  • (PMID = 19470133.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Alix T, Labbé D, Caquant L, Comoz F, Compère JF, Bénateau H: [Management of whole-scalp tumour: the Poncet-Spiegler cylindroma or turban tumour]. Rev Stomatol Chir Maxillofac; 2009 Apr;110(2):109-12
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  • INTRODUCTION: The Poncet-Spiegler cylindroma (PSC) is a benign annexal cutaneous tumor which preferentially develops on the scalp, neck, or forehead.
  • The treatment was a complete scalp exeresis and secondary reconstruction with a skin graft.
  • In case of turban tumor, total scalp exeresis and secondary reconstruction with a skin graft is recommended.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Head and Neck Neoplasms / surgery. Scalp / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adult. Esthetics. Female. Follow-Up Studies. Humans. Neoplasm Recurrence, Local / surgery. Reconstructive Surgical Procedures. Skin Transplantation / methods

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  • (PMID = 19328506.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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84. De Francesco V, Frattasio A, Pillon B, Stinco G, Scott CA, Trotter D, Patrone P: Carcinosarcoma arising in a patient with multiple cylindromas. Am J Dermatopathol; 2005 Feb;27(1):21-6
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  • Malignant tumors may occur, usually with the features of a cylindrocarcinoma.
  • In 1997 she underwent surgical excision of the entire forehead and scalp with skin grafting.
  • The lesion was excised and histologic and immunohistochemical evaluation revealed a malignant cutaneous biphasic tumor extending into the subcutis, consisting of a major portion with the features of an adnexal carcinoma and of a minor one of atypical spindle cells.
  • Biphasic malignant skin tumors are rare and only a limited number have been described, none in association with the Brooke-Spiegler syndrome.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Skin Appendage / pathology. Carcinosarcoma / pathology. Neoplasms, Second Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Skin Transplantation. Treatment Outcome

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  • (PMID = 15677972.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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85. Gildea JH, Lillehei KO, Golitz LE, Kleinschmidt-DeMasters BK: Benign cylindroma causing transcalvarial invasion in a patient with familial cylindromatosis. Clin Neuropathol; 2007 May-Jun;26(3):125-30
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  • Light microscopic and immunohistochemical characterization of resected tumor, with TP53 immunostaining in the invasive tumor was compared with that seen in five other cutaneous, non-invasive cylindromas.
  • While an uncommon occurrence, both benign and malignant cylindromas have the capacity to invade bone, particularly in patients with the familial syndrome.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Neoplastic Syndromes, Hereditary / pathology. Scalp / pathology. Skin Neoplasms / pathology. Skull / pathology


86. Oudidi A, El-Alami MN, Boulaich M, Jazouli N, Kzadri M: [Primary sub-mandibular gland tumours: experience based on 68 cases]. Rev Laryngol Otol Rhinol (Bord); 2006;127(3):187-90
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  • [Title] [Primary sub-mandibular gland tumours: experience based on 68 cases].
  • RESULTS: 68 cases were reviewed comprising 37 benign and 31 malignant tumours (15 females and 33 males).
  • Clinical suspicion of malignancy was associated with symptom of pain, cervical adenopathy, nerve palsy, skin and/or bone invasion.
  • Definitive diagnosis was by complete excision and pathological examination.
  • For malignant lesions (n= 31) the most frequent were: Adenoid cystic carcinoma (n= 10), epidermoid carcinoma (n= 5), adenocarcinoma (n= 5), mucoepidermoid carcinoma (n= 3), malignant non Hodgkinien lymphoma (n= 5).
  • For the malignant lesions it was associated acording to their extension with other anatomical region or in case of adenopathy with neck dissection.
  • Any delay in diagnosis or inappropriate management may result in a poor prognosis for the patient.
  • [MeSH-major] Submandibular Gland Neoplasms / classification. Submandibular Gland Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Early Diagnosis. Female. Humans. Male. Middle Aged. Prognosis

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  • (PMID = 17007195.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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87. Johnson H, Robles M, Kamino H, Walters RF, Lee A, Sanchez M: Trichoepithelioma. Dermatol Online J; 2008;14(10):5
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  • A 29-year-old man presented with a long-standing history of asymptomatic, skin-colored, facial papules and nodules.
  • The patient had a history of a brother with a similar phenotype, which suggests a diagnosis of familial trichoepithelioma.
  • [MeSH-major] Facial Neoplasms / diagnosis. Neoplasms, Basal Cell / diagnosis. Neoplasms, Multiple Primary / diagnosis. Neoplastic Syndromes, Hereditary / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Carcinoma, Adenoid Cystic / genetics. Genes, Tumor Suppressor. Genetic Heterogeneity. Humans. Male. Phenotype. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / physiology

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  • (PMID = 19061604.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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88. Daneshbod Y, Daneshbod K, Khademi B: Diagnostic difficulties in the interpretation of fine needle aspirate samples in salivary lesions: diagnostic pitfalls revisited. Acta Cytol; 2009 Jan-Feb;53(1):53-70
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  • These records and slides were reviewed to identify cytologic characteristics that contributed to false diagnosis.
  • RESULTS: Of a total of 1,040 salivary FNA samples, 376 cases had a final histologic diagnosis with interpretations of benign or malignant.
  • The sensitivity and specificity for correct interpretation of benign and malignant were 87% and 96%, respectively.
  • The most common false negative cases were acinic cell carcinoma, epithelial myoepithelial carcinoma, adenoid cystic carcinoma and basal cell adenocarcinoma.
  • Benign cases with false positive diagnosis were Warthin tumor and pleomorphic adenoma.
  • CONCLUSION: Knowledge of cytologic overlaps and pitfalls on salivary gland FNA, as well as clinical and radiologic features, may help clinicians arrive at the appropriate diagnosis and reduce false interpretations.
  • Several clinically important pitfalls with nonsalivary tumors of jaw and skin are demonstrated in our series.
  • [MeSH-major] Salivary Gland Neoplasms / diagnosis. Salivary Glands / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Child. Child, Preschool. Diagnosis, Differential. False Negative Reactions. False Positive Reactions. Female. Humans. Infant. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity. Young Adult

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  • (PMID = 19248555.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Malata CM, Tehrani H, Kumiponjera D, Hardy DG, Moffat DA: Use of anterolateral thigh and lateral arm fasciocutaneous free flaps in lateral skull base reconstruction. Ann Plast Surg; 2006 Aug;57(2):169-75; discussion 176
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  • Eight patients had squamous cell carcinoma, 3 had infection or osteoradionecrosis, and 1 had adenoid cystic carcinoma.
  • [MeSH-minor] Adult. Aged. Arm. Fascia / transplantation. Female. Humans. Male. Middle Aged. Skin Transplantation. Thigh

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  • (PMID = 16861997.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V: Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol; 2008 Mar-Apr;29(2):142-6
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  • [Title] Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review.
  • INTRODUCTION: Primary neoplasms of the external ear canal are rare, and 5% of these tumors are of glandular origin.
  • Ceruminal glands are modified sweat glands of the skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
  • Subsequent biopsy and histologic examination revealed pleomorphic adenoma of the external ear canal, possibly with malignant elements.
  • The patient underwent modified radical mastoidectomy and complete resection of the tumor and the entire skin of the external auditory canal.
  • Nonspecific presentation and difficult histologic diagnosis characterize this benign neoplasm.

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  • (PMID = 18314029.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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91. Bianchi B, Ferri A, Ferrari S, Copelli C, Boni P, Sesenna E: Iliac crest free flap for maxillary reconstruction. J Oral Maxillofac Surg; 2010 Nov;68(11):2706-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Abdominal Muscles / transplantation. Adult. Aged. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / surgery. Ectropion / etiology. Female. Follow-Up Studies. Humans. Ilium / surgery. Male. Maxillary Neoplasms / surgery. Maxillary Sinus Neoplasms / surgery. Middle Aged. Nasal Obstruction / etiology. Neoadjuvant Therapy. Orbit / surgery. Postoperative Complications. Skin Transplantation. Surgical Mesh. Surgical Wound Dehiscence / etiology. Tissue and Organ Harvesting / methods. Titanium

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  • [Copyright] Copyright © 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20594630.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] D1JT611TNE / Titanium
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92. Mahmoud A, Hill DH, O'Sullivan MJ, Bennett MW: Cylindroma of the breast: a case report and review of the literature. Diagn Pathol; 2009;4:30
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  • The patient had no significant family or past medical history, and specifically no history of breast or skin diseases.
  • At low power the islands of tumour cells formed a "jig-saw" pattern, which is typical of cylindroma, but was present within normal breast parenchyma and no had direct connection with the overlying skin.
  • We discuss the nine previously reported cases and the distinction of breast cylindroma from adenoid cystic carcinoma, the main differential diagnosis.

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  • (PMID = 19725978.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3224926
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93. Lin Y, Zhu H, Liu J, Wang H: [Modified sternocleidomastoid myocutaneous flap for reconstruction of soft tissue defects following tumorectomy of maxillofacial region]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2010 Apr;24(4):452-4

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  • There were 27 cases of well-differentiated squamous cell carcinoma (SC), 14 cases of poorly-differentiated SC, 1 case of rhabdomyosarcoma, and 1 case of adenoid cystic carcinoma.
  • The 3 patients with buccal carcinoma could open their mouths normally.
  • The function of deglutition and pronunciation were recovered in 24 patients with tongue carcinoma.
  • In 26 patients who were followed up above 2 years, oral metaplasia of the the skin flaps epithelium was observed.
  • [MeSH-major] Skin Transplantation / methods. Soft Tissue Injuries / surgery. Surgical Flaps

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  • (PMID = 20459009.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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94. Liukko T, Mäkitie AA, Markkola A, Ylikoski J, Bäck L: Radiofrequency induced thermotherapy: an alternative palliative treatment modality in head and neck cancer. Eur Arch Otorhinolaryngol; 2006 Jun;263(6):532-6
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  • Five patients had pharyngeal carcinomas, one had an unknown primary tumour growing through the skin on the neck, two had a recurrent malignant melanoma originating from the maxillary sinuses, one had a carcinoma of the tongue, two had laryngeal carcinomas, and one had a recurrent adenoid cystic carcinoma of the parotid gland.

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  • (PMID = 16565858.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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95. Torres T, Caetano M, Alves R, Horta M, Selores M: Tender tumor of the scalp: clinicopathologic challenge. Primary cutaneous adenoid cystic carcinoma. Int J Dermatol; 2010 Jun;49(6):605-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tender tumor of the scalp: clinicopathologic challenge. Primary cutaneous adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Pain / pathology. Scalp. Skin Neoplasms / pathology. Telangiectasis / pathology

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  • (PMID = 20618463.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Numajiri T, Nishino K, Uenaka M: Giant primary cutaneous adenoid cystic carcinoma of the perineum: histological and radiological correlations. Acta Derm Venereol; 2008;88(3):316-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant primary cutaneous adenoid cystic carcinoma of the perineum: histological and radiological correlations.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Perineum / surgery. Skin Neoplasms / pathology

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  • (PMID = 18480953.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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97. Sherigar JM, Finnegan J, McManus D, Lioe TF, Spence RA: Extra salivary adenoid cystic carcinoma; report of two cases. Ulster Med J; 2006 Sep;75(3):223-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra salivary adenoid cystic carcinoma; report of two cases.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Middle Aged. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology. Tomography, X-Ray Computed

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  • (PMID = 16964816.001).
  • [ISSN] 0041-6193
  • [Journal-full-title] The Ulster medical journal
  • [ISO-abbreviation] Ulster Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Northern Ireland
  • [Other-IDs] NLM/ PMC1891784
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98. Golda N, Wheeland RG, Thomas TL, Trout C: Adenoid Basal cell carcinoma simulating ameloblastoma. Dermatol Surg; 2009 Sep;35(9):1410-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid Basal cell carcinoma simulating ameloblastoma.
  • [MeSH-major] Ameloblastoma / diagnosis. Carcinoma, Adenoid Cystic / pathology. Jaw Neoplasms / diagnosis. Mohs Surgery / methods. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Male

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  • [ErratumIn] Dermatol Surg. 2010 Apr;36(4):576. Thomas, Tracy L [added]; Trout, Colin [added]
  • (PMID = 19549180.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Bobrov VM, Trifonov SIu: [Multiple skin cylindroma of both floors of the auricle and internal acoustic meatus]. Vestn Otorinolaringol; 2005;(6):64-6

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  • [Title] [Multiple skin cylindroma of both floors of the auricle and internal acoustic meatus].
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Ear Canal. Ear Cartilage. Ear Neoplasms / pathology

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  • (PMID = 16353016.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Russia (Federation)
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100. Humphreys T: Surgical management of cylindromatosis. Skinmed; 2010 Sep-Oct;8(5):289-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Facial Neoplasms / surgery. Skin Transplantation / methods
  • [MeSH-minor] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Skin Appendage / diagnosis. Carcinoma, Skin Appendage / pathology. Carcinoma, Skin Appendage / surgery. Follow-Up Studies. Humans. Neoplastic Syndromes, Hereditary / diagnosis. Neoplastic Syndromes, Hereditary / pathology. Neoplastic Syndromes, Hereditary / surgery. Skin Neoplasms

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  • (PMID = 21137639.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Familial cylindromatosis
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