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66. Wickström SA, Masoumi KC, Khochbin S, Fässler R, Massoumi R: CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J; 2010 Jan 6;29(1):131-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis.
  • [MeSH-minor] Acetylation. Animals. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Catalytic Domain. Cell Line, Tumor. Cytokinesis. Genes, Tumor Suppressor. Humans. Keratinocytes / cytology. Keratinocytes / drug effects. Keratinocytes / metabolism. Melanocytes / cytology. Melanocytes / drug effects. Melanocytes / metabolism. Melanoma / genetics. Melanoma / metabolism. Melanoma / pathology. Mice. Microtubules / metabolism. Mutation. Recombinant Fusion Proteins / genetics. Recombinant Fusion Proteins / metabolism. Skin Neoplasms / genetics. Skin Neoplasms / metabolism. Skin Neoplasms / pathology. Tetradecanoylphorbol Acetate / pharmacology


67. Fukuda M, Fukuda F, Horiuchi Y, Oku Y, Suzuki S, Kusama K, Sakashita H: Expression of CYLD, NF-kappaB and NF-kappaB-related factors in salivary gland tumors. In Vivo; 2006 Jul-Aug;20(4):467-72
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  • The cylindromatosis (CYLD) gene was originally identified as a tumor suppressor that is mutated in familial cylindromatosis, an autosomal dominant condition that confers a predisposition to multiple tumors of the skin appendages.
  • Adenoid cystic carcinoma (ACC) is a well known and typical malignant SGT ACC was previously known as cylindroma in view of its marked histological resemblance to dermal cylindroma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. NF-kappa B / metabolism. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 16900776.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / NF-kappa B; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; 0 / Tumor Suppressor Proteins; 0 / Ubiquitin; EC 2.7.11.10 / I-kappa B Kinase
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68. Perez DE, Magrin J, de Almeida OP, Kowalski LP: Multiple cutaneous metastases from a parotid adenoid cystic carcinoma. Pathol Oncol Res; 2007;13(2):167-9
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  • [Title] Multiple cutaneous metastases from a parotid adenoid cystic carcinoma.
  • Cutaneous metastasis from salivary gland adenoid cystic carcinoma is extremely rare.
  • We report a case of a 39-year-old man that presented multiple cutaneous metastases from a parotid salivary gland adenoid cystic carcinoma.
  • This case shows the importance of a detailed and periodical skin examination in patients treated for salivary gland adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Parotid Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Gene Expression Regulation, Neoplastic. Humans. Keratin-7 / genetics. Keratin-7 / metabolism. Male. Proto-Oncogene Proteins c-kit / genetics. Proto-Oncogene Proteins c-kit / metabolism. Skin / metabolism. Skin / pathology. Vimentin / genetics. Vimentin / metabolism

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  • (PMID = 17607381.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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69. Numajiri T, Nishino K, Uenaka M: Giant primary cutaneous adenoid cystic carcinoma of the perineum: histological and radiological correlations. Acta Derm Venereol; 2008;88(3):316-8
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  • [Title] Giant primary cutaneous adenoid cystic carcinoma of the perineum: histological and radiological correlations.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Perineum / surgery. Skin Neoplasms / pathology

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  • (PMID = 18480953.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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70. Köstler E, Schönlebe J, Mentzel T, Haroske G, Wollina U: Psoriasis and Brooke-Spiegler syndrome with multiple malignancies. J Eur Acad Dermatol Venereol; 2005 May;19(3):380-1
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  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Multiple Primary / complications. Parotid Neoplasms / pathology. Psoriasis / etiology. Skin Neoplasms / pathology


71. Lui PC, Fan YS, Lau PP, Chau TK, Tang VW, Tse GM, Yu AM, Vong JS, Tan PH, Trendell-Smith NJ: Vulvar basal cell carcinoma in China: a 13-year review. Am J Obstet Gynecol; 2009 May;200(5):514.e1-5
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  • [Title] Vulvar basal cell carcinoma in China: a 13-year review.
  • OBJECTIVE: We conducted a 12-year retrospective review of vulvar basal cell carcinoma (BCC) in a Chinese population.
  • The predominant histologic pattern was nodular, which may be mistaken as adenoid cystic carcinoma.
  • Formal histopathologic assessment should be used to reach an objective diagnosis.
  • [MeSH-major] Carcinoma, Basal Cell / ethnology. Carcinoma, Basal Cell / pathology. Vulvar Neoplasms / ethnology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Asian Continental Ancestry Group / statistics & numerical data. Biopsy. Female. Frozen Sections. Hong Kong / epidemiology. Humans. Incidence. Middle Aged. Retrospective Studies. Skin Neoplasms / ethnology. Skin Neoplasms / pathology. Skin Pigmentation

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  • (PMID = 19200934.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Bowen S, Gill M, Lee DA, Fisher G, Geronemus RG, Vazquez ME, Celebi JT: Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation. J Invest Dermatol; 2005 May;124(5):919-20
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  • Patients with BSS are predisposed to multiple skin appendage tumors such as cylindroma, trichoepithelioma, and spiradenoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Skin Appendage / genetics. Mutation. Neoplasms, Multiple Primary / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics


73. Kim C, Kovich OI, Dosik J: Brooke-Spiegler syndrome. Dermatol Online J; 2007;13(1):10
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  • A 46-year-old woman with Brooke-Spiegler syndrome has multiple cutaneous adnexal neoplasms on her face and scalp.
  • Etiology, clinical features, malignant transformation, and treatment modalities for Brooke-Spiegler syndrome are reviewed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Face. Female. Humans. Middle Aged. Scalp. Syndrome

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  • (PMID = 17511943.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Gildea JH, Lillehei KO, Golitz LE, Kleinschmidt-DeMasters BK: Benign cylindroma causing transcalvarial invasion in a patient with familial cylindromatosis. Clin Neuropathol; 2007 May-Jun;26(3):125-30
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  • Light microscopic and immunohistochemical characterization of resected tumor, with TP53 immunostaining in the invasive tumor was compared with that seen in five other cutaneous, non-invasive cylindromas.
  • While an uncommon occurrence, both benign and malignant cylindromas have the capacity to invade bone, particularly in patients with the familial syndrome.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Neoplastic Syndromes, Hereditary / pathology. Scalp / pathology. Skin Neoplasms / pathology. Skull / pathology


75. Puizina-Ivić N, Sapunar D, Marasović D, Mirić L: An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis. Coll Antropol; 2008 Oct;32 Suppl 2:61-5
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  • [Title] An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis.
  • In this study the authors have analyzed imunohistochemically the expression of Bcl-2 protein in the histopathological variants of the most common malignant tumors of the skin--basal cell carcinoma (BCC) and squamous cell tumor (SCC), as well as in the precancerous lesion actinic keratosis (AK) and in benign tumor seborrheic keratosis (SK).
  • Bcl-2 expression in solid, adenoid and cystic variants of BCC exhibited immunoreactivity of tumor stroma with more intense staining among peripheral palisading cells.
  • In three histological variants of SK expresseion of Bcl-2 protein was in areas of basaloid proliferation, while in areas of squamous differentiation was negative.
  • In clonal variant immunostaining was positive among cells in characteristic "nests" Distribution of Bcl-2 protein expression in solid, adenoid and cystic variant of BCC showed that peripheral proliferating cells are protected against apoptosis what permits tumor growth.
  • In AK results suggest that immunoreactivity is regulated with respect of the keratinocyte's differentiation status, but not closely correlate with proliferative rate.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Keratosis, Actinic / metabolism. Keratosis, Seborrheic / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Skin Neoplasms / metabolism


76. Kazakov DV, Kutzner H, Rütten A, Mukensnabl P, Michal M: Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma. Am J Dermatopathol; 2005 Jun;27(3):195-203
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  • [Title] Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma.
  • This report emphasizes a carcinoid-like pattern, a previously unrecognized feature in cutaneous sebaceous neoplasms.
  • The cases included 6 men and 1 woman, with their ages at the diagnosis ranging from 43 to 87 years (median age, 59).
  • Sebaceous differentiation in the form of mature sebocytes varied from almost none to approximately 10%.
  • Four lesions represented sebaceomas, and in 1 case microscopic delineation between a carcinoma and sebaceoma was difficult.
  • No neuroendocrine differentiation was demonstrated immunohistochemically, histochemically, and ultrastructurally.
  • Electron microscopic examination performed in 1 case of carcinoma revealed lipid vacuoles in a minority of cells.
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Diagnosis, Differential. Female. History, 16th Century. Humans. Immunohistochemistry. Inclusion Bodies / pathology. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / ultrastructure. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 15900121.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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77. Jarrett R, Walker L, Bowling J: Dermoscopy of Brooke-Spiegler syndrome. Arch Dermatol; 2009 Jul;145(7):854
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Dermoscopy. Skin Neoplasms / pathology

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  • (PMID = 19620580.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Jereczek-Fossa BA, Krengli M, Orecchia R: Particle beam radiotherapy for head and neck tumors: radiobiological basis and clinical experience. Head Neck; 2006 Aug;28(8):750-60
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  • It is now well accepted that there are certain indications for using proton therapy for skull base tumors (chordoma and chondrosarcoma), paranasal sinus carcinomas, selected nasopharyngeal tumors, and neutron/ion therapy for salivary gland carcinomas (in particular, adenoid cystic tumors).
  • Its viability in other cases, such as locally advanced squamous cell carcinoma, melanoma, soft tissue sarcoma, and bone sarcoma, is still under investigation.
  • [MeSH-minor] Chordoma / radiotherapy. Humans. Melanoma / radiotherapy. Nose Neoplasms / radiotherapy. Pharyngeal Neoplasms / radiotherapy. Radiobiology. Radiotherapy Dosage. Salivary Gland Neoplasms / radiotherapy. Skin Neoplasms / radiotherapy. Skull Base Neoplasms / radiotherapy

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  • (PMID = 16804876.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 80
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79. Popa I, Welt L, Constantin G, Popa E, Bordea A, Burcoş T, Iosif C, Angelescu N: [Adenoid cystic carcinoma of the breast--two case reports]. Chirurgia (Bucur); 2010 Nov-Dec;105(6):827-30
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  • [Title] [Adenoid cystic carcinoma of the breast--two case reports].
  • [Transliterated title] Carcinom adenoid chistic mamar--prezentare a două cazuri.
  • Adenoid cystic carcinoma is a rare type of breast carcinoma with a good prognosis.
  • We present two cases of adenoid cystic carcinoma diagnosed in the Surgical Department of Coltea Hospital in the last 3 years.
  • The first case is a 66 years old patient with a breast tumor that has clinical and imagistic features compatible with a benign diagnosis.
  • The frozen sections established the diagnosis of adenoid cystic carcinoma, confirmed by histopathologic examination of paraffin embedded tissue and immunohistochemistry.
  • The second case is a 68 years old patient with a breast tumor located in the central quadrant of the left breast, with skin infiltration.
  • The frozen sections established the diagnosis of ductal invasive carcinoma and histopathologic examination of paraffin embedded tissue and immunohistochemistry established the diagnosis of adenoid cystic carcinoma associated with ductal invasive carcinoma grade I and adenomyoepitelioma.
  • [MeSH-major] Adenomyoepithelioma / pathology. Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Carcinoma, Ductal, Breast / pathology. Diagnosis, Differential. Female. Humans. Lymph Node Excision. Mastectomy. Neoplasm Staging. Treatment Outcome

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  • (PMID = 21355181.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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80. Ricard AS, Laurentjoye M, Faucher A, Zwetyenga N, Siberchicot F, Majoufre-Lefebvre C: [276 cases of horizontal infrahyoid myocutaneous flap]. Rev Stomatol Chir Maxillofac; 2009 Jun;110(3):135-7
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  • The horizontal design of the skin paddle is a modification of this technique allowing for a smaller scar.
  • DISCUSSION: Modifying the infrahyoid myocutaneous flap technique with a horizontal design of the skin paddle does not modify the reliability of the flap and prevents more extensive scars.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Neck Muscles / transplantation. Skin Transplantation / methods. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / surgery. Cicatrix / prevention & control. Female. Gingival Neoplasms / surgery. Graft Survival. Humans. Male. Middle Aged. Mouth Floor / surgery. Mouth Neoplasms / surgery. Oropharyngeal Neoplasms / surgery. Postoperative Complications. Reconstructive Surgical Procedures / methods. Retrospective Studies. Tongue Neoplasms / surgery. Treatment Outcome. Venous Insufficiency / etiology

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  • (PMID = 19403148.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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81. Benchetritt M, Butori C, Long E, Ilie M, Ferrari E, Hofman P: Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: diagnostic cytopathology from an exfoliative sample. Diagn Cytopathol; 2008 May;36(5):351-4
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  • [Title] Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: diagnostic cytopathology from an exfoliative sample.
  • Adenoid cystic carcinoma (ACC) occurs not only as a tumor of salivary glands, but also in very unusual locations, such as in the skin.
  • Only very few cases of primary cutaneous of ACC have metastasized to the lymph nodes and lungs.
  • We present a 53-year-old man with metastasis of the pericardium from a primary cutaneous ACC (PCACC) of the scalp, which had been surgically treated 14 years ago.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Heart Neoplasms / secondary. Pericardial Effusion / pathology. Pericardium / pathology. Skin Neoplasms / pathology


82. Crain N, Nelson BL, Barnes EL, Thompson LD: Ceruminous gland carcinomas: a clinicopathologic and immunophenotypic study of 17 cases. Head Neck Pathol; 2009 Mar;3(1):1-17
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  • BACKGROUND: Ceruminal gland carcinomas are rare neoplasms confined to the skin lining the cartilaginous part of the external auditory canal.
  • Histologically, the tumors demonstrated a solid to cystic pattern, composed of an infiltrating glandular to cribriform arrangement of epithelial cells.
  • Tumors were divided into three types of adenocarcinoma based on pattern of growth and cell type (ceruminous, NOS [n = 12], adenoid cystic [n = 4], mucoepidermoid [n = 1]).
  • CK7 and CD117 highlighted the luminal cells, while S1-00 protein showed a predilection for the basal cells of ceruminous and adenoid cystic carcinomas.
  • CONCLUSION: Ceruminous-type carcinomas, with the exception of ceruminous mucoepidermoid carcinoma, all demonstrated a dual cell population of basal myoepithelial-type cells and luminal apocrine cells.
  • [MeSH-major] Carcinoma / pathology. Ear Neoplasms / pathology. Ear, External / pathology

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  • (PMID = 20596983.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807538
  • [Keywords] NOTNLM ; Adenoid cystic / Carcinoma / Ceruminal / Ceruminous / Ear / Gland / Immunohistochemistry / Mucoepidermoid / Prognosis
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83. Dores GM, Huycke MM, Devesa SS, Garcia CA: Primary cutaneous adenoid cystic carcinoma in the United States: incidence, survival, and associated cancers, 1976 to 2005. J Am Acad Dermatol; 2010 Jul;63(1):71-8
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  • [Title] Primary cutaneous adenoid cystic carcinoma in the United States: incidence, survival, and associated cancers, 1976 to 2005.
  • BACKGROUND: Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare appendageal tumor of uncertain origin.
  • [MeSH-major] Carcinoma, Adenoid Cystic / epidemiology. Skin Neoplasms / epidemiology
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / epidemiology. Survival Rate. United States / epidemiology

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  • [Copyright] Copyright (c) 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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  • (PMID = 20447723.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CP010183-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS135983; NLM/ PMC2885489
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84. Komander D: CYLD tidies up dishevelled signaling. Mol Cell; 2010 Mar 12;37(5):589-90
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  • [MeSH-major] Adaptor Proteins, Signal Transducing / metabolism. Carcinoma, Adenoid Cystic / metabolism. Phosphoproteins / metabolism. Protein Processing, Post-Translational. Signal Transduction. Skin Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism. Wnt Proteins / metabolism. beta Catenin / metabolism

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  • [Copyright] (c) 2010 Elsevier Inc. All rights reserved.
  • [CommentOn] Mol Cell. 2010 Mar 12;37(5):607-19 [20227366.001]
  • (PMID = 20227361.001).
  • [ISSN] 1097-4164
  • [Journal-full-title] Molecular cell
  • [ISO-abbreviation] Mol. Cell
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U105192732
  • [Publication-type] Journal Article; Comment
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / CTNNB1 protein, human; 0 / CYLD protein, human; 0 / Dishevelled Proteins; 0 / Phosphoproteins; 0 / Tumor Suppressor Proteins; 0 / Wnt Proteins; 0 / Wnt3 Protein; 0 / beta Catenin; K3Z4F929H6 / Lysine
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85. Oranje AP, Halley D, den Hollander JC, Teepe RG, van de Graaf R, van den Ouweland A, Wagner A: Multiple familial trichoepithelioma and familial cylindroma: one cause! J Eur Acad Dermatol Venereol; 2008 Nov;22(11):1395-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Adenoid Cystic / etiology. Skin Neoplasms / etiology

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  • (PMID = 18355210.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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86. Sherigar JM, Finnegan J, McManus D, Lioe TF, Spence RA: Extra salivary adenoid cystic carcinoma; report of two cases. Ulster Med J; 2006 Sep;75(3):223-5
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  • [Title] Extra salivary adenoid cystic carcinoma; report of two cases.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Middle Aged. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology. Tomography, X-Ray Computed

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  • (PMID = 16964816.001).
  • [ISSN] 0041-6193
  • [Journal-full-title] The Ulster medical journal
  • [ISO-abbreviation] Ulster Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Northern Ireland
  • [Other-IDs] NLM/ PMC1891784
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87. Fukuda M, Hiroi M, Suzuki S, Ohmori Y, Sakashita H: Loss of CYLD might be associated with development of salivary gland tumors. Oncol Rep; 2008 Jun;19(6):1421-7
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  • Molecular studies of cylindromas, which arise from the eccrine or apocrine cells of the skin, have demonstrated frequent alterations at chromosome 16q12-13, recently found to house the cylindromatosis (CYLD) gene.
  • We demonstrated previously that human salivary gland tumor (SGT) cell line, HSG spontaneously expresses CYLD and also found that adenoid cystic carcinoma (ACC) arising from the hard palate was distinctly positive for CYLD, immunohistochemically.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Genes, Tumor Suppressor / physiology. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 18497946.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / NF-kappa B; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Transcription Factor RelA; 0 / Tumor Necrosis Factor-alpha; 0 / Tumor Suppressor Proteins; EC 2.7.11.10 / I-kappa B Kinase
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88. Scott AR, Faquin WC, Deschler DG: Parotid mass in a woman with multiple cutaneous cylindromas. Head Neck; 2010 May;32(5):684-7
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  • [Title] Parotid mass in a woman with multiple cutaneous cylindromas.
  • BACKGROUND: Familial autosomal dominant cylindromatosis (FADC) is a rare disease characterized by multiple cutaneous cylindromas, trichoepitheliomas, and spiradenomas.
  • METHODS: Biopsy of a skin nodule demonstrated cylindroma, and fine-needle aspiration of the parotid mass suggested membranous basal cell adenoma, which was confirmed following superficial parotidectomy.
  • Seventeen cases involved the parotid gland; there are 2 reports of malignant transformation.
  • Membranous basal cell adenoma may be mistaken for adenoid cystic carcinoma on cytologic or histologic examination.
  • Total parotidectomy with facial nerve preservation or superficial parotidectomy with close follow-up is recommended, as multifocality and malignant transformation exist.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19455704.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Kazakov DV, Benkova K, Michal M, Vanecek T, Kacerovska D, Skalova A: Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. Hum Pathol; 2009 Oct;40(10):1499-503
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  • [Title] Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene.
  • It appears identical to cutaneous cylindroma, hence the synonym dermal analogue tumor.
  • We present a case of a tumor involving the parotid gland that appeared identical to cutaneous spiradenoma.
  • In addition, the lesion had a malignant component identical to basal cell adenocarcinoma.
  • This is the first report of a "dermal analogue tumor" of the salivary gland that resembled a cutaneous spiradenoma and not a cylindroma.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Parotid Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 19454360.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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90. Kshirsagar AY, Wader JV, Langade YB, Jadhav KP, Zaware SU, Shekhar N: Adenoid cystic carcinoma of the male breast. Int Surg; 2006 Jul-Aug;91(4):234-6
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  • [Title] Adenoid cystic carcinoma of the male breast.
  • This was histopathologically diagnosed as an adenoid cystic carcinoma of the left breast.
  • Periodic acid schiff (PAS) staining confirmed the diagnosis.
  • Wide excision of the recurrent malignant nodules over the anterior chest wall was done, and the defect was covered primarily with split thickness skin grafting.
  • [MeSH-major] Breast Neoplasms, Male / surgery. Carcinoma, Adenoid Cystic / surgery


91. Singh A, Ramesh V: Primary cutaneous adenoid cystic carcinoma with distant metastasis: a case report and brief literature review. Indian J Dermatol Venereol Leprol; 2010 Mar-Apr;76(2):176-9
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  • [Title] Primary cutaneous adenoid cystic carcinoma with distant metastasis: a case report and brief literature review.
  • Primary adenoid cystic carcinoma (PCACC) of skin is a rare tumor, and those who show distant metastasis are even rarer.
  • We report a case of PCACC on the face of a 55-year-old man who showed bilateral lung metastasis and on palliative chemotherapy showed significant regression of the primary tumor.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 20228549.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 11
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92. Bobrov VM, Trifonov SIu: [Multiple skin cylindroma of both floors of the auricle and internal acoustic meatus]. Vestn Otorinolaringol; 2005;(6):64-6
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  • [Title] [Multiple skin cylindroma of both floors of the auricle and internal acoustic meatus].
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Ear Canal. Ear Cartilage. Ear Neoplasms / pathology

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  • (PMID = 16353016.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Russia (Federation)
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93. Brandt SM, Swistel AJ, Rosen PP: Secretory carcinoma in the axilla: probable origin from axillary skin appendage glands in a young girl. Am J Surg Pathol; 2009 Jun;33(6):950-3
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  • [Title] Secretory carcinoma in the axilla: probable origin from axillary skin appendage glands in a young girl.
  • Invasive carcinoma in the axilla may arise from skin appendage glands or ectopic breast tissue or it may be a metastasis.
  • Carcinomas of the skin adnexal glands and breast can be difficult to distinguish from each other as they often display the same patterns of growth.
  • Tubular, cribriform, papillary, apocrine, mucinous, and adenoid cystic are histologic types of carcinoma seen in the breast and skin appendage glands.
  • To our knowledge, secretory carcinoma, the most common form of mammary carcinoma in children, has not yet been described as a morphologic pattern of skin adnexal carcinoma, although we cannot exclude the possibility that such a case was reported with a different diagnosis.
  • We report a case of a young girl with secretory carcinoma that seems to have arisen from skin appendage glands in the skin of the axilla in the absence of demonstrable ectopic breast tissue.
  • [MeSH-major] Axilla / pathology. Carcinoma, Skin Appendage / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Am J Surg Pathol. 2010 Aug;34(8):1226-7; author reply 1228 [20631609.001]
  • (PMID = 19342945.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Fernandez-Flores A, Pol A, Juanes F, Crespo LG: Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies. Med Mol Morphol; 2007 Dec;40(4):212-7
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  • [Title] Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies.
  • We report a cribriform carcinoma of the left fossa poplitea in a 62-year-old woman.
  • The patient did not present any symptoms, and the only complaint was the nodule, which was resected for diagnosis.
  • After considering different diagnostic options, we decided that the most appropriate one was cribriform carcinoma, which is an entity described in 1998.
  • The diagnostic criteria, which were provided in the few publications that refer to this entity, helped us to distinguish it from the main mimicker: cystic adenoid carcinoma.
  • [MeSH-major] Adenocarcinoma / immunology. Adenocarcinoma / pathology. Antibodies, Neoplasm / immunology. Skin Neoplasms / immunology. Skin Neoplasms / pathology


95. Schmaltz R, Müller CS, Vogt T: [Sudden growth of previously indolent scalp nodule]. Hautarzt; 2010 Jun;61(6):518-21
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  • Cylindromas are benign adnexal tumors with eccrine and apocrine differentiation.
  • Malignant changes are rare; possible clues are ulceration, bleeding or sudden growth of the lesions.
  • We present a case of scalp cylindromatosis in which a primary cutaneous adenoid-cystic carcinoma developed.
  • As our case shows, histological evaluation is mandatory, even when the clinical diagnosis seems obvious.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Cell Transformation, Neoplastic / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Multiple Primary / diagnosis. Scalp. Skin Neoplasms / diagnosis

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  • (PMID = 20490442.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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96. Wang Y, Feng GS, Tian H, Zhang ZH, Xiong T: [Fluorescent imaging of angiogenesis and spontaneous metastasis in transplanted hepatoma: experiment with mice]. Zhonghua Yi Xue Za Zhi; 2007 Dec 11;87(46):3307-9
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  • OBJECTIVE: To establish stable enhanced green fluorescent protein (GFP) -expressing human adenoid cystic carcinoma (ACC-M-GFP) cell lines with high lung metastatic potential, and to study the value and influential factor of in vivo monitoring of metastasis and angiogenesis by fluorescent imaging.
  • METHODS: Human adenoid cystic carcinoma cell line ACC-M-GFP labeled with enhanced GFP was established.
  • Once the subcutaneous tumor reached 0.5 cm in diameter, it was removed, cut into 1 mm3 pieces, and implanted into the left hepatic lobe of 8 nude mice.
  • By whole-body optical system, the fluorescent signal from the liver tumor was detected through a skin-flap window after 6 - 8 weeks.
  • Tumors were visualized directly through skin after 8 - 10 weeks.
  • [MeSH-minor] Animals. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cell Line, Tumor. Green Fluorescent Proteins / genetics. Green Fluorescent Proteins / metabolism. Humans. Mice. Mice, Inbred BALB C. Mice, Nude. Microscopy, Fluorescence. Transplantation, Heterologous

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  • (PMID = 18396632.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 147336-22-9 / Green Fluorescent Proteins
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97. Rajan N, Langtry JA, Ashworth A, Roberts C, Chapman P, Burn J, Trainer AH: Tumor mapping in 2 large multigenerational families with CYLD mutations: implications for disease management and tumor induction. Arch Dermatol; 2009 Nov;145(11):1277-84
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  • Differentiation between the clinical diagnoses has little prognostic or clinical utility in genetic counseling, even within individuals from the same family.
  • Thus, we suggest an encompassing diagnosis of "CYLD cutaneous syndrome."
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Genetic Predisposition to Disease / epidemiology. Germ-Line Mutation. Head and Neck Neoplasms / genetics. Skin Neoplasms / diagnosis. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age of Onset. Biopsy, Needle. Child. Cohort Studies. DNA Mutational Analysis. Deafness / diagnosis. Female. Follow-Up Studies. Gene Expression Regulation, Neoplastic. Genetic Testing / methods. Humans. Immunohistochemistry. Incidence. Male. Middle Aged. Pedigree. Phenotype. Risk Factors. Scalp / surgery. Sensitivity and Specificity. Sex Distribution. Sexual Dysfunction, Physiological / diagnosis. Syndrome. Young Adult

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  • (PMID = 19917957.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / A8363; United Kingdom / Medical Research Council / / G0701367; United Kingdom / Medical Research Council / / G0701367(84978); United Kingdom / Cancer Research UK / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
  • [Other-IDs] NLM/ PMC2935681; NLM/ UKMS31751
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98. Kim UR, Shah AD, Shanti R, Arora V: Primary adenoid cystic carcinoma of the eyelid. Ophthal Plast Reconstr Surg; 2010 Mar-Apr;26(2):134-6
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  • [Title] Primary adenoid cystic carcinoma of the eyelid.
  • Adenoid cystic carcinoma is a rare epithelial malignancy, which tends to grow slowly.
  • An excisional biopsy with wide margins revealed a diagnosis of primary adenoid cystic carcinoma of eyelid skin with perineural invasion.
  • Although a rare neoplasm, primary adenoid cystic carcinoma of eyelid skin should be included in the differential diagnosis of eyelid tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Eyelid Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 20305522.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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99. Lian F, Cockerell CJ: Cutaneous appendage tumors: familial cylindromatosis and associated tumors update. Adv Dermatol; 2005;21:217-34
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  • [Title] Cutaneous appendage tumors: familial cylindromatosis and associated tumors update.
  • [MeSH-major] Carcinoma, Skin Appendage. Sweat Gland Neoplasms
  • [MeSH-minor] Acrospiroma. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Genes, Tumor Suppressor. Humans. Mutation. Tumor Suppressor Proteins / genetics

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  • (PMID = 16350444.001).
  • [ISSN] 0882-0880
  • [Journal-full-title] Advances in dermatology
  • [ISO-abbreviation] Adv Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 52
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100. Oosterkamp HM, Neering H, Nijman SM, Dirac AM, Mooi WJ, Bernards R, Brummelkamp TR: An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis. Br J Dermatol; 2006 Jul;155(1):182-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Familial cylindromatosis is a rare genetic disorder, giving rise to neoplasms of the skin appendages.
  • [MeSH-major] Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Skin Appendage / drug therapy. Keratolytic Agents / administration & dosage. Neoplastic Syndromes, Hereditary / drug therapy. Salicylic Acid / administration & dosage

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  • (PMID = 16792771.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratolytic Agents; 0 / NF-kappa B; EC 2.7.11.10 / I-kappa B Kinase; O414PZ4LPZ / Salicylic Acid
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