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6. Saghravanian N, Mohtasham N, Jafarzadeh H: Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. J Oral Sci; 2009 Dec;51(4):509-14
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  • [Title] Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
  • Adenoid cystic carcinoma (AdCC) and polymorphous low-grade adenocarcinoma (PLGA) have several common histological and clinicopathological features that may create diagnostic difficulties.
  • In this study, 10 AdCCs, 8 PLGAs, and 5 normal minor salivary glands as a control group were selected.
  • Thus, immunohistochemistry can be helpful for differential diagnosis of AdCC and PLGA, particularly that for CEA, vimentin, and Ki-67.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor. Carcinoma, Adenoid Cystic / chemistry. Salivary Gland Neoplasms / chemistry
  • [MeSH-minor] Carcinoembryonic Antigen / analysis. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Ki-67 Antigen / analysis. Vimentin / analysis


7. Wegner A, Waśniewska E, Jarmołowska-Jurczyszyn D, Golusiński W, Biczysko W: [The role of immunohistochemical staining (protein p53, cyclin D1) in the prognosis of adenoid cystic carcinoma salivary gland tumors]. Otolaryngol Pol; 2007;61(4):423-7
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  • [Title] [The role of immunohistochemical staining (protein p53, cyclin D1) in the prognosis of adenoid cystic carcinoma salivary gland tumors].
  • [Transliterated title] Rola badań immunohistochemicznych (białka p53, cykliny D1) w prognozowaniu raka gruczołowato-torbielowatego (carcinoma adenoides cysticum) ślinianek.
  • INTRODUCTION: Adenoid cystic carcinoma of the salivary glands (carcinoma adenoides cysticum) is malignant epithelial tumor of rare occurrence.
  • Tumor of this kind has among salivary glands tumors uncertain prognosis and unpredictable course.
  • MATERIAL AND METHODS: The examined group consisted of 30 patients with adenoid cystic carcinoma of the salivary glands.
  • There was not statistically significant difference between the advanced grading of the organic and clinical adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Cyclin D1 / biosynthesis. Salivary Gland Neoplasms / diagnosis. Tumor Suppressor Protein p53 / biosynthesis


8. Emanuel P, Wang B, Wu M, Burstein DE: p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Mod Pathol; 2005 May;18(5):645-50
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  • [Title] p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma.
  • Morphologic distinction of high-grade adenoid cystic carcinoma from basaloid squamous cell carcinoma can be difficult.
  • Archival, routinely processed slides were subjected to citrate-based antigen retrieval, exposure to anti-p63 monoclonal 4A4, and developed with a streptavidin-biotin kit and diaminobenzidine as chromogen. p63 was detected in 100% of the adenoid cystic carcinomas (n=14) and 100% of basaloid squamous cell carcinomas (n=16).
  • In contrast, adenoid cystic carcinoma displayed a consistently compartmentalized pattern within tumor nests.
  • (1) selective staining of a single peripheral layer of p63-positive cells surrounding centrally located tumor cells that were p63-negative and (2) tumor nests consisting of multiple contiguous glandular/cribriform-like units of p63-positive cells surrounding or interspersed with p63-negative cells. p63 immunostaining constitutes a specific and accurate means of distinguishing adenoid cystic carcinoma from basaloid squamous cell carcinoma. p63 positivity in adenoid cystic carcinoma appears to be homologous to that seen in the basal and/or myoepithelial compartments of salivary gland and other epithelia, and may signify a stem-cell-like role for these peripheral cells.
  • Diffuse p63 positivity in basaloid squamous cell carcinoma suggests dysregulation of p63-positive stem cells in poorly differentiated squamous carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Phosphoproteins / analysis. Trans-Activators / analysis
  • [MeSH-minor] DNA-Binding Proteins. Diagnosis, Differential. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 15529180.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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9. Netto Jde N, Miranda AM, da Silveira HM, dos Santos TC, Pires FR: Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Aug;106(2):242-5
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  • [Title] Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma.
  • BACKGROUND: Fine-needle aspiration biopsy (FNAB) is useful in diagnosis of major salivary gland adenoid cystic carcinoma (ACC), but it has been rarely reported on minor salivary gland ACC.
  • OBJECTIVE: The aim of this study was to report the utility of FNAB on diagnosis of ACC involving minor salivary glands.
  • Diagnosis of the 3 cases was subsequently confirmed through histopathology.
  • CONCLUSION: The FNAB was easy to perform and cost-effective, and proved to be an useful adjunctive tool in diagnosis of intraoral ACC.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adult. Cell Nucleus / ultrastructure. Cheek / pathology. Coloring Agents. Cytodiagnosis / methods. Cytoplasm / ultrastructure. Diagnosis, Differential. Extracellular Space. Female. Fluorescent Dyes. Humans. Male. Middle Aged. Mouth Mucosa / pathology. Palatal Neoplasms / pathology

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  • (PMID = 18644520.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Fluorescent Dyes
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10. Dincer N, Tezel GG, Sungur A, Himmetoglu C, Huebner K, Güler G: Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland. Oral Oncol; 2010 Mar;46(3):195-9
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  • [Title] Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland.
  • Mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) are salivary gland neoplasms with divergent morphological features and clinical behavior.
  • In previous studies, we have shown concordant loss of Fhit and Wwox expression in breast cancer, with significantly more frequent loss in cancers of basal-like phenotype.
  • To determine if there is a similar association in salivary gland neoplasms, we designed a study of MEC and ACC of salivary gland on tissue microarrays (TMA).
  • TMAs were constructed from 25 MEC and 19 ACC of salivary gland.
  • The results suggest that, as for breast cancer, loss of Fhit and Wwox expression might have a role in the pathogenesis of basaloid differentiation in salivary gland neoplasms; alternatively, differences in chromatin structure at chromosome fragile regions might make fragile genes more accessible to DNA damage and rearrangement early during preneoplastic stages of basaloid cancers.
  • [MeSH-major] Acid Anhydride Hydrolases / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / metabolism. Neoplasm Proteins / metabolism. Oxidoreductases / metabolism. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism

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  • [Copyright] (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20060354.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Tumor Suppressor Proteins; 0 / fragile histidine triad protein; EC 1.- / Oxidoreductases; EC 1.1.1.- / WWOX protein, human; EC 3.6.- / Acid Anhydride Hydrolases
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11. Talmon GA, Khan A, Koerber R, Lele S, Johansson S: A cribriform urothelial neoplasm of the renal pelvis: an adenoid cysticlike variant of inverted urothelial papilloma or florid ureteritis cystica? Arch Pathol Lab Med; 2010 Oct;134(10):1557-9
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  • [Title] A cribriform urothelial neoplasm of the renal pelvis: an adenoid cysticlike variant of inverted urothelial papilloma or florid ureteritis cystica?
  • Tumors with cribriform appearance, similar to that of salivary gland adenoid cystic carcinoma, have been described at various anatomic sites.
  • The mass displayed a prominent cribriform architecture, akin to adenoid cystic carcinoma with an immunophenotype that supported a urothelial origin.
  • This cribriform urothelial neoplasm of the renal pelvis may, in fact, represent a variant of an inverted urothelial neoplasm with a prominent cystic component or florid ureteritis cystica.
  • [MeSH-major] Carcinoma, Transitional Cell / pathology. Neoplasms, Connective Tissue / pathology. Papilloma / pathology. Papilloma, Inverted / pathology. Urologic Neoplasms / pathology. Urothelium / pathology
  • [MeSH-minor] Aged, 80 and over. Cell Division. Diagnosis, Differential. Humans. Immunophenotyping / methods. Kidney Pelvis / pathology. Male. Proto-Oncogene Proteins c-kit / analysis. Urinary Bladder Neoplasms / pathology

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  • (PMID = 20923313.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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12. Daa T, Yada N, Kashima K, Suzuki M, Yokoyama S: Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland. Mol Med Rep; 2009 Jan-Feb;2(1):13-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland.
  • SMAD4, also known as DPC4 (deleted in pancreatic carcinoma 4) was initially identified as a tumor-suppressor gene.
  • It is located on 18q21, a region frequently deleted in pancreatic carcinoma.
  • Functionally inactivating mutation of the gene also occurs in many cases of pancreatic cancer.
  • Functional loss of SMAD4 is frequently detected not only in pancreatic carcinoma but also in colorectal carcinoma.
  • The purpose of this study was to elucidate the role of SMAD4 in adenoid cystic carcinoma of the salivary glands.
  • We examined 34 cases of adenoid cystic carcinoma for loss of heterozygosity (LOH) of the SMAD4 locus and for the existence of mutations of the gene.
  • In conclusion, the infrequent LOH of the SMAD4 gene locus and lack of SMAD4 mutations indicate that SMAD4 does not play a role in the tumorigenesis of adenoid cystic carcinoma of the salivary gland.

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  • (PMID = 21475783.001).
  • [ISSN] 1791-2997
  • [Journal-full-title] Molecular medicine reports
  • [ISO-abbreviation] Mol Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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13. Handra-Luca A, Mauguen A, Ménard P, Fouret P: Coordinated expression of activated mitogen-activated protein kinases in salivary gland adenoid cystic carcinoma. Hum Pathol; 2008 Nov;39(11):1590-6
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  • [Title] Coordinated expression of activated mitogen-activated protein kinases in salivary gland adenoid cystic carcinoma.
  • Little is known regarding the mitogen-activated protein kinase activation state in salivary gland adenoid cystic carcinoma.
  • Our study provides evidence that mitogen-activated protein kinases are activated in adenoid cystic carcinoma and suggests that their activation is coordinated.
  • [MeSH-major] Carcinoma, Adenoid Cystic / enzymology. Mitogen-Activated Protein Kinases / metabolism. Salivary Gland Neoplasms / enzymology

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  • (PMID = 18657296.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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4. Wang XF, Wu DM, Li BX, Lu YJ, Yang BF: Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma. Phytother Res; 2009 Mar;23(3):303-7
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  • [Title] Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma.
  • The present study aimed to evaluate the growth-inhibitory effect of sulforaphane (SFN) and a traditional chemotherapy agent, 5-fluorouracil (5-Fu), against the proliferation of salivary gland adenoid cystic carcinoma high metastatic cell line (ACC-M) and low metastasis cell line (ACC-2).
  • [MeSH-major] Carcinoma, Adenoid Cystic / drug therapy. Fluorouracil / pharmacology. Salivary Gland Neoplasms / drug therapy. Thiocyanates / pharmacology

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  • [Copyright] (c) 2008 John Wiley & Sons, Ltd.
  • (PMID = 18844240.001).
  • [ISSN] 1099-1573
  • [Journal-full-title] Phytotherapy research : PTR
  • [ISO-abbreviation] Phytother Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Isothiocyanates; 0 / Thiocyanates; 0 / Transcription Factor RelA; 4478-93-7 / sulforafan; U3P01618RT / Fluorouracil
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15. Teymoortash A, Ramaswamy A, Werner JA: [Adenoid cystic carcinoma secondary to heterotopic salivary gland tissue of the cervical lymph nodes]. Laryngorhinootologie; 2007 Jan;86(1):44-7
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  • [Title] [Adenoid cystic carcinoma secondary to heterotopic salivary gland tissue of the cervical lymph nodes].
  • [Transliterated title] Adenoidzystisches Karzinom im heterotopen Speicheldrüsengewebe der zervikalen Lymphknoten.
  • BACKGROUND: The presence of heterotopic salivary gland tissue in intra-, periparotideal and cervical lymph nodes is not an uncommen finding.
  • In some rare cases the salivary gland inclusions in lymph nodes may undergo neoplastic transformation.
  • The histological assessment of the extirpated node seemed to indicate lymph node metastasis of an adenoid cystic carcinoma.
  • RESULTS: Due to the fact of missing of a primary tumor, the diagnosis of an adenoid cystic carcinoma in heterotopic salivary gland tissue of the cervical lymph node was established after long-term observation.
  • CONCLUSION: After exclusion of an occult carcinoma of the salivary glands, the possibility of malignant transformation of heterotopic intranodal salivary gland inclusions should be considered in patients suffering from salivary gland carcinoma in the area of the cervical lymph nodes.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Cell Transformation, Neoplastic / pathology. Choristoma / pathology. Lymph Nodes / pathology. Otorhinolaryngologic Neoplasms / pathology. Salivary Glands
  • [MeSH-minor] Diagnosis, Differential. Humans. Lymph Node Excision. Male. Middle Aged

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  • (PMID = 16586289.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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16. Dardick I, Daley TD, McComb RJ: Sialoblastoma in adults: distinction from adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jan;109(1):109-16
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  • [Title] Sialoblastoma in adults: distinction from adenoid cystic carcinoma.
  • No adult cases have been reported with a specific diagnosis of sialoblastoma.
  • If even focal cribriforming were present, such cases have undoubtedly been diagnosed as adenoid cystic carcinoma.
  • Each case, however, has the primitive histopathology with discrete nests of basaloid tumor cells, associated bilayered ductal structures and the fibromyxoid stroma characteristic for sialoblastoma with its resemblance to fetal salivary gland or salivary gland with arrested development.
  • Sialoblastoma, whether in a child or adult with or without a cribriform growth pattern, appears to have a more favorable prognosis than adenoid cystic carcinoma.
  • Aspects of the histological differential diagnosis of these 2 tumors are discussed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Palatal Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Facial Paralysis / etiology. Female. Humans. Male. Middle Aged. Palate, Hard / pathology. Parotid Neoplasms / complications. Parotid Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 19880331.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Fu ZC, Zhang B, Fu ZJ: As2O3 may be a treatment option for adenoid cystic carcinoma of salivary gland. Med Hypotheses; 2010 Dec;75(6):490-1
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  • [Title] As2O3 may be a treatment option for adenoid cystic carcinoma of salivary gland.
  • Adenoid cystic carcinoma (ACC) is an uncommon tumor of the head and neck that may occur in any salivary gland tissue.
  • ACC mostly occurring in the major and minor salivary glands, has some unique characteristics such as slow growth, diffuse invasion, and high incidence of distant metastasis.
  • It is a high malignant carcinoma characterized by intensive local invasion and insidious distant metastasis to the lung at an early stage, which is responsible for a poor long-term survival rate.
  • The main clinical treatment to adenoid cystic carcinoma depended on surgical operation in the past.
  • However, it was not so easy to completely excise adenoid cystic carcinoma which resulting in the residual of tumor cells.
  • Adenoid cystic carcinoma is not sensitive to conventional chemotherapeutics, so it is necessary to explore a new kind of drug which possesses inhibition and killing effects to this tumor.
  • It also induces apoptosis in a variety of cancer cells over a wide dose range.
  • A(S2)O(3) may become a treatment option for adenoid cystic carcinoma of salivary gland.
  • [MeSH-major] Apoptosis / drug effects. Arsenicals / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Growth Inhibitors / therapeutic use. Oxides / therapeutic use. Salivary Gland Neoplasms / drug therapy

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20656411.001).
  • [ISSN] 1532-2777
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arsenicals; 0 / Growth Inhibitors; 0 / Oxides; S7V92P67HO / arsenic trioxide
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18. Florentine BD, Fink T, Avidan S, Braslavsky D, Raza A, Cobb CJ: Extra-salivary gland presentations of adenoid cystic carcinoma: a report of three cases. Diagn Cytopathol; 2006 Jul;34(7):491-4
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  • [Title] Extra-salivary gland presentations of adenoid cystic carcinoma: a report of three cases.
  • Adenoid cystic carcinoma (ACC) is a malignant neoplasm most commonly originating in salivary glands of the head and neck area.
  • When ACC presents outside of these locations, the diagnosis may become more challenging.
  • We describe three cases of ACC presenting in extra-salivary gland sites.
  • In conclusion, ACC can present in various body sites and cytologists must consider this neoplasm when presented with a basaloid carcinoma of uncertain origin.
  • [MeSH-major] Bone Neoplasms / secondary. Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Pleural Effusion / pathology

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16783770.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Mücke T, Tannapfel A, Kesting MR, Wagenpfeil S, Robitzky LK, Wolff KD, Hölzle F: Adenoid cystic carcinomas of minor salivary glands. Auris Nasus Larynx; 2010 Oct;37(5):615-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinomas of minor salivary glands.
  • OBJECTIVES: Adenoid cystic carcinoma (ACC) is a very rare epithelioid tumor with different prognostic factors relating to overall survival.
  • MATERIALS AND METHODS: From 1992 to 2006, a total of 33 patients with ACC originating in minor salivary glands of the oral cavity were clinicopathologically reviewed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Neoplasm Recurrence, Local / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20181451.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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20. Deshpande AH, Kelkar AA: Hepatic metastasis as an initial manifestation of salivary adenoid cystic carcinoma: Cytologic diagnosis. Diagn Cytopathol; 2009 Jan;37(1):45-7
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  • [Title] Hepatic metastasis as an initial manifestation of salivary adenoid cystic carcinoma: Cytologic diagnosis.
  • Adenoid cystic carcinoma is a malignant tumor of the salivary glands.
  • We present the case of a 68-year-old male with complaints and radiological findings suggestive of primary hepatocellular carcinoma.
  • However, fine-needle aspiration findings showed metastasis of adenoid cystic carcinoma.
  • A retrospective clinical and ultrasound examination of the patient revealed a small asymptomatic enlargement of the submandibular salivary gland that was aspirated and showed features of adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Liver Neoplasms / secondary. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Humans. Male. Submandibular Gland / pathology. Submandibular Gland / ultrasonography. Tomography, X-Ray Computed

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18973128.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Chu WF, Wu DM, Liu W, Wu LJ, Li DZ, Xu DY, Wang XF: Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma. Oral Oncol; 2009 Nov;45(11):998-1004
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  • [Title] Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma.
  • New chemotherapeutic strategy should be investigated to enhance clinical management in salivary gland adenoid cystic carcinoma (ACC).
  • Recently, sulforaphane (SFN), as a natural compound from cruciferous vegetables exhibits a potent anti-cancer activity in various tumor cells, but remains uncertain in ACC cells.
  • Cell survives, apoptosis, cell cycle progression and molecular targets were identified by multiple detecting techniques, including trypan blue dye exclusion assay, electron microscopy, AO/EB staining, flow cytometry and immunoblotting in human lung high metastasis cell line of salivary gland adenoid cystic carcinoma (ACC-M).
  • [MeSH-major] Anticarcinogenic Agents / pharmacology. Carcinoma, Adenoid Cystic / drug therapy. Lung Neoplasms / drug therapy. Salivary Gland Neoplasms / drug therapy. Thiocyanates / pharmacology


22. Yang GC, Waisman J: Distinguishing adenoid cystic carcinoma from cylindromatous adenomas in salivary fine-needle aspirates: the cytologic clues and their ultrastructural basis. Diagn Cytopathol; 2006 Apr;34(4):284-8
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  • [Title] Distinguishing adenoid cystic carcinoma from cylindromatous adenomas in salivary fine-needle aspirates: the cytologic clues and their ultrastructural basis.
  • The utilization of fine-needle aspiration (FNA) biopsy in salivary tumors is hindered by the reluctance of many cytopathologists to report adenoid cystic carcinoma (ACC) because its cylindromatous stroma is observed occasionally in pleomorphic adenoma (PA) and basal cell adenoma (BA), and a diagnosis of ACC results in radical surgery.
  • In conclusion, in our analysis of salivary tumors with a cylindromatous pattern, the seemingly naked nuclei of neoplastic cells with their coarse nuclear chromatin and irregular nucleoli, as revealed by the UFP stain, reliably distinguished ACC from cylindromatous adenomas.
  • [MeSH-major] Adenoma / pathology. Adenoma / ultrastructure. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / ultrastructure. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 16544336.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Ciccolallo L, Licitra L, Cantú G, Gatta G, EUROCARE Working Group: Survival from salivary glands adenoid cystic carcinoma in European populations. Oral Oncol; 2009 Aug;45(8):669-74
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  • [Title] Survival from salivary glands adenoid cystic carcinoma in European populations.
  • Adenoid cystic carcinoma (ACC) of salivary gland origin is rare.
  • The EUROCARE data provide a good opportunity to study the survival of this uncommon cancer in a large population.
  • A total of 2611 cases, aged 15 to 99 years, diagnosed between 1983 and 1994 with primary salivary gland ACC were analyzed.
  • Thirty-two population based cancer registries from seventeen countries participating in EUROCARE contributed the data.
  • Relative survival by sex, age, period of diagnosis, region, site and stage, and the adjusted relative excess risk (RER) of death were estimated.
  • Survival since diagnosis was 94%, 78% and 65% at 1, 5 and ten years, respectively.
  • A strong effect of stage at diagnosis on RERs and some worsening of survival at five years over time (80% in 1983-1985, 76% in 1992-1994) were also evident.
  • The findings of the present study, as those from clinical studies, confirm the important impact of primary site and stage at diagnosis on survival.
  • [MeSH-major] Carcinoma, Adenoid Cystic / mortality. Rare Diseases / mortality. Salivary Gland Neoplasms / mortality

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  • (PMID = 19095489.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Investigator] Oberaigner W; Storm HH; Aareleid T; Jechova M; Rousarova M; Hakulinen T; Hédelin G; Tron I; Le Gall E; Launoy G; Macé-Lesec'h J; Faivre J; Chaplain G; Carli PM; Danzon A; Tretarre B; Colonna M; Lacour B; Raverdy N; Berger C; Freycon B; Grosclaude P; Estève J; Kaatsch P; Ziegler H; Hölzel D; Schubert Fritschle G; Tryggvadottir L; Berrino F; Allemani C; Baili P; Ciccolallo L; Crosignani P; Gatta G; Micheli A; Sant M; Taussig E; Sowe S; Ferretti S; Conti E; Vercelli M; Quaglia A; Pannelli F; Federico M; Artioli ME; Ponz De Leon M; Benatti P; De Lisi V; Servente L; Zanetti R; Patriarca S; Magnani C; Pastore G; Gafa L; Tumino R; Falcini F; Budroni M; Paci E; Crocetti E; Zambon P; Guzzinati S; Capocaccia R; Carrani E; De Angelis R; Roazzi P; Santaquilani M; Tavilla A; Valente F; Verdecchia A; Dalmas M; Langmark F; Andersen A; Rachtan J; Bielska-Lasota M; Wronkowski Z; Plesko I; Obsitníková A; Pompe-Kirn V; Primic Zakelj M; Izarzugaza I; Martinez-Garcia C; Garau I; Navarro C; Chirlaque MD; Ardanaz E; Moreno C; Galceran J; Torrella A; Peris-Bonet R; Barlow L; Möller L; Jundt G; Lutz JM; Bouchardy C; Coebergh JW; Visser O; Godward S; Coleman MP; Williams EM; Forman D; Quinn MJ; Roche M; Edwards S; Stiller C; Verne J; Møller H; Bell J; Botha JL; Lawrence G; Black R; Steward JA
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24. Beltran D, Faquin WC, Gallagher G, August M: Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma. J Oral Maxillofac Surg; 2006 Mar;64(3):415-23
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  • [Title] Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma.
  • PURPOSE: Polymorphous low-grade adenocarcinoma (PLGA) is a salivary gland malignancy characterized by indolent growth and a low rate of metastasis.
  • PLGA shares histological features with adenoid cystic carcinoma (ACC), including infiltrating solid and cribriform patterns, presence of cystic spaces, and neurotropism.
  • CONCLUSIONS: Statistically significant immunohistochemical staining patterns using c-kit and SMA in this study support their potential use as markers to differentiate PLGA from ACC in cases where the diagnosis can be challenging.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. Salivary Gland Neoplasms / chemistry. Salivary Gland Neoplasms / classification
  • [MeSH-minor] Actins / analysis. Adult. Aged. Aged, 80 and over. Cytoskeletal Proteins / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Muscle Proteins / analysis. Neoplasm Proteins / analysis. Proto-Oncogene Proteins c-kit / analysis. Statistics, Nonparametric

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  • (PMID = 16487803.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Ki-67 Antigen; 0 / Muscle Proteins; 0 / Neoplasm Proteins; 0 / Smooth muscle protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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25. Hara H, Oyama T, Suda K: New criterial for cytologic diagnosis of adenoid cystic carcinoma. Acta Cytol; 2005 Jan-Feb;49(1):43-50
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  • [Title] New criterial for cytologic diagnosis of adenoid cystic carcinoma.
  • OBJECTIVE: To formulate new criteria for adenoid cystic carcinoma (ADCC).
  • STUDY DESIGN: The usefulness of 17 items for a cytologically definitive diagnosis of ADCC was examined.
  • The frequency (- - +++) of the 17 items in 18 cases of ADCC and 10 non-ADCC cases (pleomorphic adenoma, basal cell adenoma, myoepithelioma and epithelial-myoepithelial carcinoma) that displayed mimicking cytology was examined cytologically.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenoma / diagnosis. Adenoma / pathology. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Myoepithelioma / diagnosis. Myoepithelioma / pathology. Staining and Labeling

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  • (PMID = 15717754.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. Ge MH, Ling ZQ, Tan Z, Chen C, Zheng CM, Xu JJ, Zhu X: [RUNX3 expression and its methylation of 5'-CpG island in salivary gland adenoid cystic carcinoma cell lines ACC-2, ACC-3 and ACC-M]. Zhonghua Yi Xue Za Zhi; 2010 Dec 28;90(48):3426-30
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  • [Title] [RUNX3 expression and its methylation of 5'-CpG island in salivary gland adenoid cystic carcinoma cell lines ACC-2, ACC-3 and ACC-M].
  • OBJECTIVE: To investigate the methylation of 5'-CpG island and expression of RUNX3 in salivary gland adenoid cystic carcinoma cell lines.
  • METHODS: RT-PCR (reverse transcription-polymerase chain reaction), laser scanning confocal microscope (LSCM) and Western blot were used to detect the expression of RUNX3 gene and protein in salivary gland adenoid cystic carcinoma cell lines, ACC-2, ACC-3, and ACC-M, before/after a treatment of 5-Aza-dc respectively.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Core Binding Factor Alpha 3 Subunit / metabolism. CpG Islands. Salivary Gland Neoplasms / metabolism

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  • (PMID = 21223819.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 3 Subunit; 0 / Runx3 protein, human
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27. Khafif A, Anavi Y, Haviv J, Fienmesser R, Calderon S, Marshak G: Adenoid cystic carcinoma of the salivary glands: a 20-year review with long-term follow-up. Ear Nose Throat J; 2005 Oct;84(10):662, 664-7
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  • [Title] Adenoid cystic carcinoma of the salivary glands: a 20-year review with long-term follow-up.
  • The behavior of adenoid cystic carcinoma (ACC) of the salivary glands has been shown to be unpredictable in terms of local and distant spread and mortality.
  • We retrospectively studied 35 operations in 34 patients who had had a pathologic diagnosis of ACC of the salivary glands and who had been treated over a 20-year period and followed for a minimum of 10 years.
  • The site of origin appeared to be an important factor in survival rates; survival among patients with tumors that had originated in the parotid gland was fairly good, while survival among those with tumors that originated in the minor salivary glands was significantly worse.
  • We recommend radical surgery with complete resection for all patients with ACC of the salivary glands and a careful assessment of the neck in patients with minor salivary gland tumors.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 16382750.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Gurney TA, Eisele DW, Weinberg V, Shin E, Lee N: Adenoid cystic carcinoma of the major salivary glands treated with surgery and radiation. Laryngoscope; 2005 Jul;115(7):1278-82
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  • [Title] Adenoid cystic carcinoma of the major salivary glands treated with surgery and radiation.
  • OBJECTIVE: To examine patient characteristics, pathologic features, and treatment outcomes of adenoid cystic carcinoma of the major salivary glands.
  • Of the 29 patients fully staged at the time of diagnosis, 7 (24%) presented at American Joint Committee on Cancer stage I, 9 (31%) at stage II, 4 (14%) at stage III, and 9 (31%) at stage IV.
  • The majority originated in the parotid gland (21, 64%), with the remaining originating in either the submandibular gland (10, 30%) or the sublingual gland (2, 6%).
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Adenoid Cystic / surgery. Salivary Gland Neoplasms / radiotherapy. Salivary Gland Neoplasms / surgery


29. Zheng G, Guo CB, Yu GY, Huang MX, Pen X, Huang J: [Development of a predicting model of survival rates for patients with salivary adenoid cystic carcinoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2006 Jun;41(6):350-3
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  • [Title] [Development of a predicting model of survival rates for patients with salivary adenoid cystic carcinoma].
  • OBJECTIVE: To establish a predicting model of survival rates and to evaluate the weighted contributions of each key prognostic factor of the patients with salivary adenoid cystic carcinoma (SACC).
  • RESULTS: The significant prognostic factors influencing the survival rate were age at diagnosis, clinical presentation, TNM clinical stage, treatment, surgical margins (P < 0.05).
  • [MeSH-major] Carcinoma, Adenoid Cystic / mortality. Salivary Gland Neoplasms / mortality


30. Batzakakis D, Apostolopoulos K, Bardanis I: A case report of coexistence of a sialolith and an adenoid cystic carcinoma in the submandibular gland. Med Oral Patol Oral Cir Bucal; 2006 May;11(3):E286-8
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  • [Title] A case report of coexistence of a sialolith and an adenoid cystic carcinoma in the submandibular gland.
  • The occurrence of sialoliths in the submandibular gland is 80% due to the specific anatomy of both the gland and its duct.
  • The diagnosis is rather easy because of the obvious clinical signs of the entity.
  • The stones do not tend to occur within the gland as frequently as in the respective duct.
  • In addition to the sialolith the pathological examination revealed the existence of an adenoid cystic carcinoma (ACC), that extended to the neighboring skeletal muscle.
  • This is the reason why we believe it would be useful to report this case of a large stone (14 mm in diameter) located in the submandibular gland coexisting with ACC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / complications. Salivary Gland Calculi / complications. Submandibular Gland Neoplasms / complications

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  • (PMID = 16648756.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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31. Ayadi K, Ayadi L, Daoud E, Mnif Z, Ben Mahfoudh K, Boudawara T, Mnif J: Adenoid cystic carcinoma of the parotid with facial nerve invasion. Tunis Med; 2010 Jan;88(1):46-8
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  • [Title] Adenoid cystic carcinoma of the parotid with facial nerve invasion.
  • BACKGROUND: Adenoid cystic carcinoma comprises approximately 10% of all epithelial salivary neoplasms and most frequently involves the parotid.
  • AIM: The authors report a case of parotid adenoid cystic carcinoma with invasion and spread via the facial nerve with an emphasis on radiologic features.
  • The magnetic resonance imaging (MRI) examination showed a right parotid gland solid mass located in the deep lobe of the parotid gland with mastoid bony involvement.The mass was heterogenously enhanced.
  • Pathologic examination of the resected specimen revealed histological features of adenoid cystic carcinoma with intra neural invasion of the mastoid segment of the facial nerve.
  • CONCLUSION: This study confirms that multiplanar approach of MRI allows rapid detection of adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Facial Nerve / pathology. Parotid Neoplasms / diagnosis

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  • (PMID = 20415214.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Tunisia
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32. Brackrock S, Krüll A, Röser K, Schwarz R, Riethdorf L, Alberti W: Neutron therapy, prognostic factors and dedifferentiation of adenoid cystic carcinomas (ACC) of salivary glands. Anticancer Res; 2005 Mar-Apr;25(2B):1321-6
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  • [Title] Neutron therapy, prognostic factors and dedifferentiation of adenoid cystic carcinomas (ACC) of salivary glands.
  • PURPOSE: Analysis of the efficacy of fast neutron radiotherapy in the treatment of adenoid cystic carcinomas (ACC) of the salivary glands, identification of prognostic variables and dedifferentiation after radiotherapy.
  • PATIENTS AND METHODS: Histological slides of primary and recurrent lesions of 71 patients were reviewed to confirm the diagnosis and to analyse subtypes.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Fast Neutrons / therapeutic use. Salivary Gland Neoplasms / radiotherapy

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  • (PMID = 15865085.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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33. Marchiò C, Weigelt B, Reis-Filho JS: Adenoid cystic carcinomas of the breast and salivary glands (or 'The strange case of Dr Jekyll and Mr Hyde' of exocrine gland carcinomas). J Clin Pathol; 2010 Mar;63(3):220-8
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  • [Title] Adenoid cystic carcinomas of the breast and salivary glands (or 'The strange case of Dr Jekyll and Mr Hyde' of exocrine gland carcinomas).
  • Adenoid cystic carcinoma (AdCC) is a tumour with myoepithelial differentiation and characterised by the presence of a dual population of basaloid and luminal cells arranged in specific growth patterns.
  • However, the clinical behaviour of salivary gland and breast AdCC differs; while salivary gland lesions have a relatively high proclivity to metastasise, patients with breast AdCCs have an excellent outcome.
  • Here the clinical, morphological and molecular features, and potential therapeutic targets of salivary gland and breast AdCCs are reviewed.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 20203221.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 113
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34. Shahsavari F, Eslami M, Baghaie F, Tirgari F, Motahhary P: Immunohistochemical evaluation of p27 (kip1) in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands. Asian Pac J Cancer Prev; 2005 Oct-Dec;6(4):527-30
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  • [Title] Immunohistochemical evaluation of p27 (kip1) in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands.
  • In this study, p27 expression was investigated in pleomorphic adenomas (PAs) and adenoid cystic carcinomas (ACCs) of minor salivary glands to evaluate its utility for differentiation purposes.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Carcinoma, Adenoid Cystic / metabolism. Cyclin-Dependent Kinase Inhibitor p27 / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Glands, Minor
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Iran. Male. Middle Aged

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  • (PMID = 16436005.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
  • [Chemical-registry-number] 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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35. Prasad ML, Barbacioru CC, Rawal YB, Husein O, Wen P: Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Mod Pathol; 2008 Feb;21(2):105-14
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  • [Title] Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
  • Distinguishing adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma of the salivary glands is important for their management.
  • We studied the expression of several myoepithelial and basal/stem cell markers (smooth muscle actin, calponin, smooth muscle myosin heavy chain, metallothionein, maspin, and p63) by immunohistochemistry in 23 adenoid cystic carcinoma and 24 polymorphous low-grade adenocarcinoma, to identify the most useful marker or combination of markers that may help their diagnoses.
  • We noted diffuse expression of smooth muscle actin in 20 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (P<0.0001), calponin in 15 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (P<0.0001), smooth muscle myosin heavy chain in 15 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (P=0.001), metallothionein in 22 adenoid cystic carcinoma vs eight polymorphous low-grade adenocarcinoma (P<0.001), maspin in 22 adenoid cystic carcinoma vs 14 polymorphous low-grade adenocarcinoma, and p63 in 21 adenoid cystic carcinoma vs 14 polymorphous low-grade adenocarcinoma.
  • Diffuse smooth muscle actin expression showed the highest accuracy (91.5%) and positive predictive value (95.2%) for adenoid cystic carcinoma.
  • Thus, diffuse expression of smooth muscle actin, calponin, smooth muscle myosin heavy chain, and metallothionein was highly predictive of adenoid cystic carcinoma, whereas maspin and p63 were frequently expressed in both tumors.
  • In differentiating adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma, smooth muscle actin as a single ancillary test in support of the histological findings, appears to be as efficient as multiple immunohistochemical tests.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Epithelial Cells / metabolism. Myocytes, Smooth Muscle / metabolism. Neoplasm Proteins / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cluster Analysis. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Recurrence, Local. Salivary Glands, Minor / metabolism. Salivary Glands, Minor / pathology. Treatment Outcome


36. Fan X, Chen B, Xu J, Zhang H, Deng F, Xiang X: Methylation status of the PTEN gene in adenoid cystic carcinoma cells. Mol Med Rep; 2010 Sep-Oct;3(5):775-9
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  • [Title] Methylation status of the PTEN gene in adenoid cystic carcinoma cells.
  • The present study aimed to investigate whether PTEN promoter methylation is involved in the regulation of the PTEN gene in adenoid cystic carcinoma (ACC) cells.
  • The expression of PTEN in ACC-2 cells was found to be significantly lower than that in normal salivary gland epithelial cells using RT-PCR analysis.
  • These results indicate that the hypermethylation of the PTEN promoter region leads to lower expression of PTEN gene in ACC cells, which aids in the development of PTEN as a molecular marker for the early diagnosis of this carcinoma.

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  • (PMID = 21472313.001).
  • [ISSN] 1791-3004
  • [Journal-full-title] Molecular medicine reports
  • [ISO-abbreviation] Mol Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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37. Elkin AD, Jacobs CD: Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases. J Cancer Res Clin Oncol; 2008 Oct;134(10):1151-3
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  • [Title] Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases.
  • PURPOSE: Adenoid cystic carcinoma of the salivary gland (ACC-SG) is a slow-growing tumor that is refractory to most chemotherapeutic agents.
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Salivary Gland Neoplasms / drug therapy. Tamoxifen / therapeutic use

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  • (PMID = 18347813.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 094ZI81Y45 / Tamoxifen; 7NFE54O27T / Toremifene
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38. Nayak SP, Walke VA, Helwatkar SB, Bobhate SK: Adenoid cystic carcinoma of the external auditory canal: report of two cases. Indian J Pathol Microbiol; 2009 Oct-Dec;52(4):540-2
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  • [Title] Adenoid cystic carcinoma of the external auditory canal: report of two cases.
  • Adenoid cystic carcinoma occurring in the external auditory canal is very rare.
  • In the second case, fine needle aspiration procedure had to be abandoned due to severe pain and a biopsy was required for its diagnosis.
  • Morphologically, it resembles its more common salivary gland counterpart.
  • Though severe pain during needling may be a limiting factor, adenoid cystic carcinoma of external auditory canal can be confidently diagnosed on cytology based on which surgical management can be planned.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Ear Canal / pathology

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  • (PMID = 19805967.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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39. Yurut-Caloglu V, Caloglu M, Ozyilmaz F, Saynak M, Cosar-Alas R, Karagol H, Bayir-Angin G, Uzal C: Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature. Med Oncol; 2007;24(4):458-62
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  • [Title] Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature.
  • Adenoid cystic carcinoma is the second most common malignancy of the major and minor salivary glands after mucoepidemoid carcinoma.
  • Skeletal muscle and cutaneous metastases from adenoid cystic carcinoma of the parotid gland are extremely rare.
  • In this case, a 40-year-old man with lung and bone metastases followed by skeletal muscle and cutaneous metastases from adenoid cystic carcinoma of the right parotid gland is presented.
  • [MeSH-major] Bone Neoplasms / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis. Muscle Neoplasms / diagnosis. Parotid Neoplasms / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 17917100.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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40. Epivatianos A, Iordanides S, Zaraboukas T, Antoniades D: Adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of minor salivary glands: a comparative immunohistochemical study using the epithelial membrane and carcinoembryonic antibodies. Oral Dis; 2005 May;11(3):175-80
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  • [Title] Adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of minor salivary glands: a comparative immunohistochemical study using the epithelial membrane and carcinoembryonic antibodies.
  • OBJECTIVE: The purpose of this study was to investigate immunohistochemically the expression of epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA) in adenoid cystic carcinoma (AdCC) and polymorphous low-grade adenocarcinoma (PLGA) in an attempt to assess the ability of these markers to distinguish AdCC from PLGA when the histological features on routine hematoxylin and eosin are equivocal.
  • MATERIALS AND METHODS: Fourteen specimens of AdCC, 10 PLGA, and five normal minor salivary glands fixed in 10% formalin and embedded in paraffin, were retrieved from the files of our department and were retrospectively studied with the streptavidin-biotin complex method using the epithelial membrane and carcinoembryonic antibodies.
  • CONCLUSIONS: The results of this study suggest that the immunostaining of AdCC and PLGA with EMA and CEA could not offer an adjunctive aid in differential diagnosis between these two tumors.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoembryonic Antigen / analysis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Mucin-1 / analysis. Retrospective Studies. Salivary Gland Diseases / diagnosis. Salivary Glands, Minor


41. Chetty R, Serra S, Hsieh E: Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant. Am J Surg Pathol; 2005 Dec;29(12):1668-72
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  • [Title] Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant.
  • Two cases of a distinctive variety of basaloid squamous carcinoma (BSC) of the anal canal are described.
  • This appearance together with microcystic spaces simulated that of an adenoid cystic carcinoma.
  • BSC of the anal canal with an adenoid cystic pattern is an infrequently encountered and reported variant, although it is seen more often in the aerodigestive tract.
  • There may be an increased propensity for BSC with an adenoid cystic pattern to metastasize to the liver, but the number of cases encountered are too small to be definitive.
  • The histologic differential diagnosis is true salivary gland-type adenoid cystic carcinoma and basal cell adenocarcinoma.
  • Immunohistochemistry and awareness of this unusual pattern of BSC will facilitate the correct diagnosis being reached.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Basosquamous / pathology

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  • (PMID = 16327441.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antigens, CD20; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 50SG953SK6 / Mitomycin; 68238-35-7 / Keratins; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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42. Li L, Luo W, Gan X, Su L, Zeng W: [Adenoid cystic carcinoma of ENT associated with hard lump: a report of 9 cases]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Oct;20(19):875-7
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  • [Title] [Adenoid cystic carcinoma of ENT associated with hard lump: a report of 9 cases].
  • OBJECTIVE: To assess the clinical and pathological features of the patients with ENT adenoid cystic carcinoma (ENTACC) who presented with hard lump, and to detect its prognosis.
  • RESULT: The period from the occurrence of primary symptoms to definite diagnosis was 4 years and 3 months on average.
  • CONCLUSION: The pathological result of these 9 cases were all salivary gland derived adenoid cystic carcinoma of solid type.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Salivary Gland Neoplasms

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  • (PMID = 17168112.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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43. Al-Sukhun J, Lindqvist C, Hietanen J, Leivo I, Penttilä H: Central adenoid cystic carcinoma of the mandible: case report and literature review of 16 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Mar;101(3):304-8
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  • [Title] Central adenoid cystic carcinoma of the mandible: case report and literature review of 16 cases.
  • Central intraosseous adenoid cystic carcinoma (ACC) of the mandible, formerly known as cylindroma, is a rare neoplasm with only 16 cases reported in the literature.
  • We describe the diagnosis, etiology, and treatment of a central ACC located in the mandibular premolar region.
  • This case illustrates 2 key facts regarding the diagnosis and etiology of ACC.
  • First, central salivary gland tumors should be considered in the differential diagnosis of cystic lytic lesions in the mandible.
  • Second, even though the origin of this type of tumor is still unknown, the presence of ectopic tissue anterior to the submandibular gland in the submandibular area indicates that this tumor might be made up of ectopic embryogenic inclusions.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Mandibular Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Choristoma. Diagnosis, Differential. Female. Humans. Mandibular Diseases / diagnosis. Submandibular Gland. Submandibular Gland Neoplasms / diagnosis

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  • (PMID = 16504862.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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44. Whatley WS, Thompson JW, Rao B: Salivary gland tumors in survivors of childhood cancer. Otolaryngol Head Neck Surg; 2006 Mar;134(3):385-8
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  • [Title] Salivary gland tumors in survivors of childhood cancer.
  • The most common second malignancies are acute leukemia, bone and soft tissue tumors, and carcinoma of the skin, breast, and thyroid.
  • Although, ionizing radiation has been demonstrated to increase the risk of developing a salivary gland neoplasm, there are few reports of salivary gland neoplasms occurring in patients treated for cancer in childhood.
  • RESULTS: Twelve survivors of childhood cancer developed a salivary gland neoplasm after completion of treatment.
  • The pathology of the salivary gland tumors were mucoepidermoid carcinoma (10), adenoid cystic carcinoma (1) , and pleomorphic adenoma (1).
  • CONCLUSION: Radiation and chemotherapy used to treat patients with childhood malignancies increases the risk of developing a second neoplasm of salivary gland origin.
  • The majority of these neoplasms are malignant; mucoepidermoid carcinoma occurs most frequently.
  • [MeSH-major] Neoplasms, Second Primary / diagnosis. Salivary Gland Neoplasms / diagnosis. Survivors
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / surgery. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis / diagnosis. Male. Neck Dissection. Neoplasms / drug therapy. Neoplasms / radiotherapy. Radiotherapy, Adjuvant. Registries. Retrospective Studies. Risk Factors


45. Bell D, Roberts D, Kies M, Rao P, Weber RS, El-Naggar AK: Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications. Cancer; 2010 Dec 15;116(24):5749-56
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  • [Title] Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications.
  • BACKGROUND: Adenoid cystic carcinoma (ACC), a rare and progressive salivary malignancy, is characterized by cellular, morphologic, and clinical heterogeneity.
  • METHODS: To investigate the differential localization and expression of the c-Kit protein and the epidermal growth factor receptor (EGFR) protein, immunohistochemical analyses were performed on tissue arrays that were constructed from 199 tumors, and the results were correlated with clinicopathologic factors.

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  • [Copyright] Copyright © 2010 American Cancer Society.
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  • (PMID = 20824717.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NIDCR NIH HHS / DE / U01 DE019765; United States / NIDCR NIH HHS / DE / U01DE019756; United States / NCI NIH HHS / CA / CA16672; United States / NIDCR NIH HHS / DE / U01 DE019765-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ NIHMS219730; NLM/ PMC2998592
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46. Yu GY, Ma DQ, Gao Y: [Basic and clinical research on salivary gland tumors]. Beijing Da Xue Xue Bao; 2008 Feb 18;40(1):7-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Basic and clinical research on salivary gland tumors].
  • Salivary gland tumors are a group of the most common tumors in the oral and maxillofacial region.
  • There is little knowledge on the clinicopathologic characteristics and clinical behaviors of salivary gland tumors of various locations and subtype.
  • The management of salivary gland tumors is also controversial.
  • Therefore adjunctive methods are important for preoperative diagnosis.
  • Since 1985, our research group has performed a series of basic and clinical researches on salivary gland tumors including clinicopathologic characteristics and behavior, preoperative adjunctive diagnosis, mechanism, prevention and treatment of distant metastasis of salivary adenoid cystic carcinoma, and histogenesis of salivary gland tumor.
  • These studies have improved our knowledge on the clinical, histopathological, cytological, imaging features, and bio-behavior of different types of salivary gland tumors.
  • We have also suggested related principles of management, modified the operative methods of benign tumor of parotid gland.
  • Our efforts have raised the standards of diagnosis and treatment of salivary gland tumors.
  • [MeSH-major] Salivary Gland Neoplasms
  • [MeSH-minor] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / surgery. Humans

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  • (PMID = 18278128.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
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47. Woo VL, Bhuiya T, Kelsch R: Assessment of CD43 expression in adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, and monomorphic adenomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Oct;102(4):495-500
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of CD43 expression in adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, and monomorphic adenomas.
  • OBJECTIVE: Distinguishing between adenoid cystic carcinoma (ACC), polymorphous low-grade adenocarcinoma (PLGA), and monomorphic adenoma (MA) can occasionally pose a diagnostic challenge.
  • STUDY DESIGN: Formalin-fixed paraffin-embedded sections from 40 salivary gland tumors (12 ACCs, 14 PLGAs, and 14 MAs) accessioned from 1989 to 2002 were retrieved from the files at the Department of Pathology, Long Island Jewish Medical Center.
  • CONCLUSIONS: CD43 appears to be preferentially expressed in salivary gland ACCs compared to PLGAs and MAs.
  • [MeSH-major] Antigens, CD43 / biosynthesis. Biomarkers, Tumor / biosynthesis. Carcinoma, Adenoid Cystic / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenoma / diagnosis. Adenoma / metabolism. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 16997117.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD43; 0 / Biomarkers, Tumor
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48. Meer S, Altini M: CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology; 2007 Jul;51(1):26-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia.
  • AIMS: To evaluate cytokeratin (CK) 7/20 expression patterns in salivary gland neoplasia.
  • METHODS AND RESULTS: Formalin-fixed paraffin embedded tissue from 153 salivary gland tumours were evaluated for CK7/20 immunoreactivity.
  • The tumours included pleomorphic adenoma (n = 24), myoepithelioma (n = 9), papillary cystadenoma (n = 3), oncocytoma (n = 2), adenoid cystic carcinoma (n = 22), mucoepidermoid carcinoma (n = 21), polymorphous low-grade adenocarcinoma (n = 21), carcinoma ex-pleomorphic adenoma (n = 11), acinic cell carcinoma (n = 17), epimyoepithelial carcinoma (n = 7), oncocytic carcinoma (n = 3), hyalinizing clear cell carcinoma (n = 1), papillary cystadenocarcinoma (n = 1), salivary duct carcinoma (n = 3), adenocarcinoma (not otherwise specified) (n = 4) and squamous carcinoma (n = 4).
  • All salivary gland neoplasms showed a CK7+/CK20- immunoprofile ranging from 5 to 100%.
  • Squamous carcinoma showed negative CK7/20 immunoexpression.
  • CONCLUSIONS: Although the CK7/20 immunoprofile is not useful in distinguishing the various types of salivary gland neoplasms or between benign and malignant salivary gland tumours, it may facilitate differentiation of primary salivary gland neoplasia from metastatic tumours and squamous carcinoma, and the diagnosis of metastatic salivary gland tumours.
  • [MeSH-major] Gene Expression Profiling. Keratin-20 / metabolism. Keratin-7 / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Carcinoma, Acinar Cell / diagnosis. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Diagnosis, Differential. Gene Expression Regulation, Neoplastic. Humans. Salivary Glands / metabolism. Salivary Glands / pathology

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  • (PMID = 17593078.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
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49. Lee JH, Lee JH, Kim A, Kim I, Chae YS: Unique expression of MUC3, MUC5AC and cytokeratins in salivary gland carcinomas. Pathol Int; 2005 Jul;55(7):386-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unique expression of MUC3, MUC5AC and cytokeratins in salivary gland carcinomas.
  • The differential diagnosis of salivary gland carcinoma is often difficult because of the confusing histopathological features of the different types of salivary gland carcinomas.
  • The expression of MUC3, MUC5AC, MUC6, cytokeratin (CK)7 and CK20 was studied in 20 mucoepidermoid carcinomas (MEC), 20 adenoid cystic carcinomas (AdCC), and 11 acinic cell carcinomas (ACC).
  • These findings will be very useful for the differential diagnosis of the salivary gland carcinomas.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Immunohistochemistry. Intermediate Filament Proteins / biosynthesis. Keratin-20. Keratin-7. Keratins / biosynthesis. Male. Middle Aged. Mucin 5AC. Mucin-3. Mucins / biosynthesis

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  • (PMID = 15982212.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-3; 0 / Mucins; 68238-35-7 / Keratins
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50. Jiang J, Tang Y, Zhu G, Zheng M, Yang J, Liang X: Correlation between transcription factor Snail1 expression and prognosis in adenoid cystic carcinoma of salivary gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Dec;110(6):764-9
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  • [Title] Correlation between transcription factor Snail1 expression and prognosis in adenoid cystic carcinoma of salivary gland.
  • The aim of the present study was to study the association of Snail1 expression with clinicopathologic factors and prognosis in adenoid cystic carcinoma (ACC) of salivary gland.
  • STUDY DESIGN: Demographic variables and primary tumor site, dates of diagnoses, perineural invasion, local regional recurrence, and distant metastasis of 121 cases of salivary ACC were retrieved.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Gene Expression Regulation, Neoplastic / genetics. Salivary Gland Neoplasms / pathology. Transcription Factors / analysis. Zinc Fingers / genetics
  • [MeSH-minor] Epithelial-Mesenchymal Transition / genetics. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Prognosis. Salivary Glands / pathology. Survival Rate. Treatment Outcome

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20952218.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Transcription Factors; 0 / snail family transcription factors
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51. Andreadis D, Epivatianos A, Poulopoulos A, Nomikos A, Papazoglou G, Antoniades D, Barbatis C: Detection of C-KIT (CD117) molecule in benign and malignant salivary gland tumours. Oral Oncol; 2006 Jan;42(1):57-65
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  • [Title] Detection of C-KIT (CD117) molecule in benign and malignant salivary gland tumours.
  • In the present study we analysed the expression of this molecule in salivary gland tumours.
  • Archival formalin-fixed, paraffin-embedded sections of 40 benign and 57 malignant salivary gland tumours were retrieved and retrospectively studied immunohistochemically using a polyclonal C-KIT antibody in an Envision/HRP technique.
  • In addition five samples of chronic submandibular sialadenitis, five normal minor salivary glands and parotid or submandibular gland tissue adjacent to benign tumour were also studied.
  • C-KIT expression was observed in cases of adenoid cystic, acinic cell polymorphous low grade, epithelial-myoepithelial, carcinosarcoma and basal cell adenocarcinomas, as in luminal cells of pleomorphic adenomas, in serous acinar and only in intercalated and a small number of striated ductal cells of inflammatory salivary gland tissue, whereas normal salivary lobules were generally negative except a weak positivity of intercalated cells.
  • Contrary to other reports, this study suggests that, C-KIT protein does not appear to be an exclusively specific marker for benign or malignant salivary gland neoplasms, but may be useful in differential diagnosis of adenoid cystic carcinoma from polymorphous low grade adenocarcinoma.
  • Furthermore its expression in serous acinar cells in sialadenitis and intercalated ductal cells in normal and inflammatory lesions may indicate a possible participation in pathogenesis of both neoplastic and non-neoplastic salivary gland diseases.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. Proto-Oncogene Proteins c-kit / analysis. Salivary Gland Neoplasms / chemistry

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  • (PMID = 16140564.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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52. Edwards PC, Wasserman P: Evaluation of cystic salivary gland lesions by fine needle aspiration: an analysis of 21 cases. Acta Cytol; 2005 Sep-Oct;49(5):489-94
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  • [Title] Evaluation of cystic salivary gland lesions by fine needle aspiration: an analysis of 21 cases.
  • OBJECTIVE: To analyze the potential sources of diagnostic errors and overall accuracy rate of the fine needle aspiration biopsy (FNAB) diagnosis of cystic salivary gland neoplasms.
  • STUDY DESIGN: A 10-year (1993-2002) retrospective review of the cytopathology slides from the Division of Cytopathology, Department of Pathology, Long Island Jewish Medical Center, New Hyde Park, New York, identified a total of 97 consecutive salivary gland FNAB cases that microscopically were interpreted as representing cystic lesions.
  • RESULTS: A correct diagnosis was rendered by FNAB in 15 of 21 (72%) cases.
  • CONCLUSION: A systematic approach to the diagnosis of cystic salivary gland lesions by FNAB can result in a correct diagnosis in > 70% of cases.
  • It is important to recognize, however, that occasionally epithelial cells may not be detected on FNAB of cystic salivary gland lesions, as a result of either cellular dilution by cystfluid or inadequate sampling.
  • Regardless, with all FNABs tentatively diagnosed as a mucinous cystic lesion, the referring clinician should be informed that a low grade mucoepidermoid carcinoma cannot be ruled out.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Diagnostic Errors / prevention & control. Epithelial Cells / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Abscess / pathology. Adenolymphoma / pathology. Biopsy, Fine-Needle. Carcinoma, Mucoepidermoid / pathology. Cystadenoma / pathology. Diagnosis, Differential. Extracellular Fluid / metabolism. Histiocytes / pathology. Humans. Lymphocytes / pathology. Observer Variation. Predictive Value of Tests. Reproducibility of Results. Retrospective Studies

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  • [CommentIn] Acta Cytol. 2007 Jul-Aug;51(4):675-6 [17718154.001]
  • (PMID = 16334024.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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53. Lima SS, Soares AF, de Amorim RF, Freitas Rde A: [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases]. Braz J Otorhinolaryngol; 2005 May-Jun;71(3):335-40
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  • [Title] [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases].
  • [Transliterated title] Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos.
  • AIM: The aim of the present study is to establish the relative frequency and distribution of benign and malignant epithelial neoplasms of salivary glands in the Pathology and Cytology Laboratory, STUDY DESIGN: Historic cohort.
  • The neoplasms were individualized by gender, age, race of the patients, anatomic localization of the lesions and histopathological diagnosis.
  • RESULTS: Out of 162,312 registered cases, 245 were salivary gland epithelial neoplasms and 187 (76.33%) were benign and 58 (23.67%) were malignant.
  • Pleomorphic adenoma was the most frequent benign neoplasm (89.94%) and adenoid cystic carcinoma represented the most prevalent malignant neoplasm (22.41%).
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Salivary Gland Neoplasms / epidemiology

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  • (PMID = 16446938.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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54. Malhotra P, Deewan U, Krishnani N: Poorly differentiated thyroid carcinoma mimicking adenoid cystic carcinoma on aspiration cytology: a case report. Acta Cytol; 2009 Sep-Oct;53(5):591-3
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  • [Title] Poorly differentiated thyroid carcinoma mimicking adenoid cystic carcinoma on aspiration cytology: a case report.
  • BACKGROUND: Spherical hyaline globules present a characteristic cytologic picture classically seen in salivary gland tumors.
  • Sporadic reports of papillary and follicular carcinoma with adenoid cystic pattern are described in the literature.
  • CASE: We report, to our knowledge, the first documented case of poorly differentiated thyroid carcinoma with adenoid cystic pattern on aspiration cytology.
  • FNAC smears consisted predominantly of cells arranged around spherical hyaline globules resembling adenoid cystic carcinoma.
  • Histopathologic examination showed a poorly differentiated thyroid carcinoma.
  • CONCLUSION: Poorly differentiated carcinoma of the thyroid presents a variable cytologic picture.
  • Reliance on hyaline globules as the sole criterion results in erroneous diagnosis.
  • [MeSH-major] Biopsy, Fine-Needle. Carcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Cell Differentiation. Diagnostic Errors. Thyroid Neoplasms / pathology. Thyroid Nodule / pathology

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  • (PMID = 19798891.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins; 9010-34-8 / Thyroglobulin
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55. Hashem NN, Mara TW, Mohamed M, Zhang I, Fung K, Kwan KF, Daley TD, Diamandis EP, Darling MR: Human kallikrein 14 (KLK14) expression in salivary gland tumors. Int J Biol Markers; 2010 Jan-Mar;25(1):32-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human kallikrein 14 (KLK14) expression in salivary gland tumors.
  • OBJECTIVE: To analyze the expression of human kallikrein 14 (KLK14) in salivary gland tumors.
  • METHODS: A standard immunoperoxidase staining technique was used to assess the expression profile of KLK14 in normal salivary glands and tumors including pleomorphic adenoma (PA; n=17), adenoid cystic carcinoma (ACC; n=13) and mucoepidermoid carcinoma (MEC; n=9).
  • RESULTS: Normal salivary glands, PA, ACC and MEC showed strong expression of KLK14 in ductal and non-ductal cells.
  • CONCLUSIONS: The differences in the levels of KLK14 suggest that KLKs may aid in the differential diagnosis of salivary gland tumors.
  • The coexpression of KLKs suggests their possible involvement in an enzymatic pathway activated in salivary gland.
  • KLK14 may be a promising new biomarker in salivary gland tumors.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Kallikreins / metabolism. Salivary Gland Neoplasms / enzymology
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / enzymology. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / enzymology. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / enzymology. Case-Control Studies. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Prognosis. Reference Values. Salivary Glands / enzymology

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  • (PMID = 20155713.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.- / KLK14 protein, human; EC 3.4.21.- / Kallikreins
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56. Capodiferro S, Scully C, Macaita MG, Lo Muzio L, Favia G, Mairoano E: Bilateral intraosseous adenoid cystic carcinoma of the mandible: report of a case with lung metastases at first clinical presentation. Oral Dis; 2005 Mar;11(2):109-12
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  • [Title] Bilateral intraosseous adenoid cystic carcinoma of the mandible: report of a case with lung metastases at first clinical presentation.
  • Adenoid cystic carcinoma (ACC) represents approximately 7.5% of all carcinomas and only a few cases of intraosseous (central) ACC have been reported in the literature.
  • RESULTS: The patient presented with a painful swelling of the right retro-molar area and paraesthesia of the ipsilateral lower lip and radiological investigations disclosed bilateral radiolucent lesions of the mandible with unequivocal signs of malignancy but without intra-lesional calcifications or association with teeth roots or cystic component.
  • CONCLUSIONS: The diagnosis of intraosseous malignant salivary gland type neoplasms is very difficult in view of their rarity and lack of specific signs and mainly achieved after histological examination and complete clinico-radiological work up.
  • As surgical treatment of the patient was not indicated, due to extensive neoplastic disease, the patient is being controlled with multimodal treatment, including chemo- and radiotherapy and is alive with persistent disease 3 years after the original diagnosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Female. Humans. Neoplasm Invasiveness

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  • [ErratumIn] Oral Dis. 2005 May;11(3):195. Lacaita, MG [corrected to Macaita, MG; Favic, G [corrected to Favia, G]
  • (PMID = 15752085.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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57. Driemel O, Maier H, Kraft K, Haase S, Hemmer J: Flow cytometric DNA ploidy in salivary gland tumours. Oncol Rep; 2005 Jan;13(1):161-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Flow cytometric DNA ploidy in salivary gland tumours.
  • This study on 279 tumours of the salivary glands was conducted to analyse whether the assessment of DNA ploidy by flow cytometry may assist histopathology in discriminating benign from malignant types of tumours.
  • The malignant tumours consisted of 18 adenoid cystic adenomas, 10 mucoepidermoid carcinomas, 5 acinic cell carcinomas, 5 carcinoma in pleomorphic adenoma as well as of 12 other malignancies belonging to 7 different tumour entities.
  • Twelve of 50 malignant salivary gland tumours were aneuploid.
  • Examination of consecutive slides actually revealed small assemblies of carcinoma cells that required a final diagnosis as non-invasive carcinoma in pleomorphic adenoma.
  • The most obvious value of DNA flow cytometry in salivary gland tumours is thus its contribution to assist histopathology in identifying potentially malignant lesions.
  • [MeSH-major] DNA, Neoplasm / analysis. Flow Cytometry. Ploidies. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Salivary Glands / pathology

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  • (PMID = 15583819.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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58. Wang YY, Chen WL, Yang ZH, Huang ZQ, Li JS, Pan CB: [Effects of Ezrin gene on the proliferation and invasion activity of human salivary gland adenoid cystic carcinoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2009 Apr;44(4):203-7
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  • [Title] [Effects of Ezrin gene on the proliferation and invasion activity of human salivary gland adenoid cystic carcinoma].
  • OBJECTIVE: To examine the expression of Ezrin in human salivary gland adenoid cystic carcinoma and investigate the effects of Ezrin gene silence on cell proliferation, apoptosis and invasion of adenoid cystic carcinoma (ACC)-M.
  • METHODS: The expression of Ezrin was detected by immunohistochemistry in normal salivary gland tissue (n=15), pleomorphic adenoma (n=40) and salivary gland adenoid cystic carcinoma (n=43).
  • RESULTS: The positive rate of Ezrin expression in ACC was significantly higher than that in normal salivary gland tissue and pleomorphic adenoma (P<0.05).
  • CONCLUSIONS: Over expression of Ezrin in human salivary gland adenoid cystic carcinoma may promote genesis, development and metastasis of tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Cytoskeletal Proteins / genetics. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 19575999.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cytoskeletal Proteins; 0 / ezrin
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59. Ozkara SK, Turan G: Fine needle aspiration cytopathology of primary solid adenoid cystic carcinoma of the lung: a case report. Acta Cytol; 2009 Nov-Dec;53(6):707-10
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  • [Title] Fine needle aspiration cytopathology of primary solid adenoid cystic carcinoma of the lung: a case report.
  • BACKGROUND: Adenoid cystic carcinoma (ACC) is a rare, distinctive salivary gland malignant neoplasm arising infrequently as a primary tumor in the lung.
  • CONCLUSION: A preoperative cytopathologic diagnosis of poorly differentiated primary pulmonary ACC can enhance surgical planning and success of tumor resection.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Lung / pathology. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology

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  • (PMID = 20014565.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Fehr A, Stenman G, Bullerdiek J, Löning T: [Molecular markers in salivary gland tumors: their use in diagnostic and prognostic workup]. Pathologe; 2009 Nov;30(6):466-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Molecular markers in salivary gland tumors: their use in diagnostic and prognostic workup].
  • The molecular genetic background of salivary gland neoplasms has not been characterized in detail to date.
  • CRTC1-MAML2 in mucoepidermoid carcinoma, or PLAG1 and HMGA2 in pleomorphic adenoma.
  • This is also true for the most frequent malignant salivary gland tumors after the mucoepidermoid carcinoma, i.e. adenoid cystic carcinomas and acinic cell carcinomas.
  • [MeSH-major] Biomarkers, Tumor / genetics. Neoplasm Proteins / genetics. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / pathology. Carcinoma, Acinar Cell. Carcinoma, Adenoid Cystic. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / pathology. Chromosome Aberrations. Comparative Genomic Hybridization. DNA Mutational Analysis. DNA-Binding Proteins. Gene Fusion. HMGA2 Protein. Humans. Nuclear Proteins. Prognosis. Protein Array Analysis. Salivary Glands / pathology. Transcription Factors

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  • (PMID = 19784654.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CRTC1 protein, human; 0 / DNA-Binding Proteins; 0 / HMGA2 Protein; 0 / MAML2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / PLAG1 protein, human; 0 / Transcription Factors
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61. Daa T, Kaku N, Kashima K, Nakayama I, Yokoyama S: Expression of beta-catenin, E-cadherin and cyclin D1 in adenoid cystic carcinoma of the salivary gland. J Exp Clin Cancer Res; 2005 Mar;24(1):83-7
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  • [Title] Expression of beta-catenin, E-cadherin and cyclin D1 in adenoid cystic carcinoma of the salivary gland.
  • We evaluated the expression of beta-catenin, E-cadherin, and cyclin-D1 in 23 cases of adenoid cystic carcinoma (ACC) of the salivary gland.
  • [MeSH-major] Cadherins / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cyclin D1 / metabolism. Cytoskeletal Proteins / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / pathology. Trans-Activators / metabolism


62. Sartorius C, Gille F, Bédrossian-Pfingsten J, Kempf HG: [Salivary duct carcinoma of the sublingual gland--a case report]. Laryngorhinootologie; 2006 Jul;85(7):517-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Salivary duct carcinoma of the sublingual gland--a case report].
  • [Transliterated title] Das Speichelgangkarzinom der Glandula Sublingualis.
  • RATIONALE: Pleomorphic adenoma is the most common neoplasm of major and minor salivary gland origin, followed by infectious reasons and sialolithiasis.
  • The salivary duct carcinoma represents a rare variant of the group of adenocarcinomas originated from the salivary glands, especially extremely rare from minor salivary gland origin.
  • A biopsy showed a rare salivary duct carcinoma of comedo-type originated from the left sublingual salivary gland.
  • DISCUSSION: Salivary duct carcinoma is a rare, high-grade malignant epithelial neoplasm, which occurs almost exclusively in the parotid.
  • As presented, it can also occur in minor salivary glands.
  • Histologically it is composed of structures that resemble expanded salivary glands.
  • There is some histologic similarity to intraductal carcinoma of the breast.
  • Differential diagnosis comprises adenoid cystic carcinoma, metastases of other adenocarcinomas, such as the carcinoma of the thyroid gland and the comedocarcinoma of the breast.
  • CONCLUSION: A rare case of a salivary duct carcinoma of sublingual salivary gland origin is presented.
  • [MeSH-major] Carcinoma, Ductal. Salivary Ducts. Salivary Gland Neoplasms. Sublingual Gland
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Prognosis. Time Factors

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  • (PMID = 16586279.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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63. Malhotra KP, Agrawal V, Pandey R: High grade transformation in adenoid cystic carcinoma of the parotid: report of a case with cytologic, histologic and immunohistochemical study. Head Neck Pathol; 2009 Dec;3(4):310-4
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  • [Title] High grade transformation in adenoid cystic carcinoma of the parotid: report of a case with cytologic, histologic and immunohistochemical study.
  • Adenoid cystic carcinoma (ACC) constitutes about 4% of salivary epithelial tumors and is the second common malignant epithelial salivary gland tumor involving both the major and minor salivary glands.
  • The locally invasive salivary neoplasm was composed predominantly of an undifferentiated carcinoma with foci of conventional ACC occupying less than 10% of tumor area.
  • Recognition of occasional clusters of basaloid cells and hyaline globules in association with larger poorly differentiated malignant cell population in aspiration smears can help in cytological diagnosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology

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  • [Cites] Hum Pathol. 2001 Dec;32(12):1403-7 [11774177.001]
  • [Cites] Histopathology. 2003 Dec;43(6):604-6 [14636262.001]
  • [Cites] Mod Pathol. 2003 Dec;16(12):1265-72 [14681328.001]
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  • [Cites] Am J Surg Pathol. 2007 Nov;31(11):1683-94 [18059225.001]
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  • (PMID = 20016788.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
  • [Keywords] NOTNLM ; Adenoid cystic / Carcinoma / Cytology / Ki-67 / Parotid / Pathology / p53
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64. Mücke T, Kesting MR, Hohlweg-Majert B, Hölzle F, Wolff KD: The role of bronchoscopy and gastroscopy in intraoral minor salivary gland carcinomas at initial staging. Br J Oral Maxillofac Surg; 2009 Dec;47(8):608-11
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  • [Title] The role of bronchoscopy and gastroscopy in intraoral minor salivary gland carcinomas at initial staging.
  • Intraoral minor salivary gland carcinomas are rare tumours the incidence, distribution, and prognostic factors of which differ.
  • The aim of this study was to assess the value of bronchoscopy and gastroscopy in the routine staging of minor salivary gland cancers.
  • We retrospectively reviewed the casenotes of 95 patients who had presented with newly diagnosed intraoral minor salivary gland carcinomas.
  • Data were collected about abnormalities detected during endoscopic screening; a biopsy was taken if reasonable and if the resulting diagnosis influenced the planned treatment.
  • One oesophageal cancer was detected by gastroscopy.
  • For therapeutic, diagnostic, and prognostic reasons bronchoscopy and gastroscopy should be included routinely into staging of intraoral minor salivary gland carcinomas.
  • [MeSH-major] Bronchoscopy. Carcinoma / pathology. Gastroscopy. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy. Bronchitis / diagnosis. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Esophageal Neoplasms / diagnosis. Female. Gastroenteritis / diagnosis. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Male. Mass Screening. Middle Aged. Mouth Mucosa / pathology. Neoplasm Staging. Neoplasms, Multiple Primary / diagnosis. Palate / pathology. Retrospective Studies

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  • (PMID = 19162382.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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65. Adeyemo WL, Ajayi OF, Anunobi CC, Ogunlewe MO, Ladeinde AL, Omitola OG, Abdulkareem FB: Tumours of the submandibular salivary gland: a clinicopathologic review of cases over a 17-year period. West Indian Med J; 2009 Sep;58(4):388-91

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  • [Title] Tumours of the submandibular salivary gland: a clinicopathologic review of cases over a 17-year period.
  • OBJECTIVE: This study presents a clinicopathologic review of cases of submandibular salivary gland tumours at the Lagos University Teaching Hospital, Nigeria, over a period of 17 years.
  • METHODS: The records of all patients with histological diagnosis of submandibular salivary gland tumours at the Lagos University Teaching Hospital over a period of 17 years (January 1990 to December 2006) were retrospectively reviewed.
  • Parameters studied were; age and gender of patients, symptoms and duration of symptoms, and histological diagnosis.
  • RESULTS: A total of 36 patients with submandibular gland tumours were seen during the period.
  • Pleomorphic adenoma (36.1%) was the most frequent tumours, followed by adenoid cystic carcinoma (11.1%), anaplastic carcinoma (11.1%) and malignant lymphoma (11.1%).
  • Patients with histological diagnosis of malignant tumours were significantly older than those with benign tumours (p = 0.01).
  • CONCLUSION: Malignant submandibular salivary gland tumours were slightly more than the benign ones in the studied population.
  • Painful swelling or ulceration is indicative of a malignant submandibular gland tumour
  • [MeSH-major] Submandibular Gland Neoplasms / diagnosis
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma / diagnosis. Carcinoma / pathology. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Female. Humans. Lymphoma / diagnosis. Lymphoma / pathology. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20099784.001).
  • [ISSN] 0043-3144
  • [Journal-full-title] The West Indian medical journal
  • [ISO-abbreviation] West Indian Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Jamaica
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66. Ettl T, Schwarz S, Kühnel T, Stockmann P, Reichert TE, Driemel O: [Prognostic value of immunohistochemistry in salivary gland cancer]. HNO; 2008 Feb;56(2):231-8
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  • [Title] [Prognostic value of immunohistochemistry in salivary gland cancer].
  • BACKGROUND: The diversity of salivary gland malignancies as to morphology and clinical course makes it difficult to establish prognostic factors.
  • The aim of this study was to evaluate the prognostic significance of, a. o., immunohistochemical criteria in a retrospective study of salivary gland cancer.
  • PATIENTS AND METHODS: Clinical and histologic data were recorded for 101 patients with carcinomas of the salivary glands.
  • RESULTS: Findings included the following: an association between loss of maspin and the presence of nodal metastasis, residual tumour, and poor overall survival for adenoid cystic carcinoma; common C-KIT expression in adenoid cystic carcinoma (92%); correlation of loss of C-KIT with high malignancy grade, nodal metastases, high proliferative activity (Ki-67>30%), and unfavourable survival in all tumours; common HER2 expression (83%) in salivary duct carcinoma but no relation to the total collective's survival.
  • High proliferative activity (Ki-67>30%) is the strongest negative predictor in salivary gland cancer.
  • Besides well-known clinicopathological factors, current immunohistochemical markers such as maspin, EGFR, and C-KIT can contribute to establish prognosis in salivary gland cancer.
  • [MeSH-major] Biomarkers, Tumor / analysis. Neoplasm Proteins / analysis. Risk Assessment / methods. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / mortality


67. Tang Y, Liang X, Zhu G, Zheng M, Yang J, Chen Y: Expression and importance of zinc-finger transcription factor Slug in adenoid cystic carcinoma of salivary gland. J Oral Pathol Med; 2010 Nov;39(10):775-80
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  • [Title] Expression and importance of zinc-finger transcription factor Slug in adenoid cystic carcinoma of salivary gland.
  • However, there is little information on the expression and role of Slug in salivary adenoid cystic carcinoma (ACC).
  • METHOD: Demographic variables and primary tumor site, dates of diagnoses, perineural invasion, local regional recurrence, and distant metastasis of 121 cases of salivary ACC treated at the Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University between 1996 and 2005 were retrieved.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology. Transcription Factors / metabolism. Zinc Fingers / physiology

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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 20738754.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Transcription Factors; 0 / snail family transcription factors
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68. Ladeinde AL, Adeyemo WL, Ogunlewe MO, Ajayi OF, Omitola OG: Salivary gland tumours: a 15-year review at the Dental Centre Lagos University Teaching Hospital. Afr J Med Med Sci; 2007 Dec;36(4):299-304
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  • [Title] Salivary gland tumours: a 15-year review at the Dental Centre Lagos University Teaching Hospital.
  • The aim of this study was to determine the relative frequency of tumours of the salivary gland seen at the Dental Centre, Lagos University Teaching Hospital, Nigeria over a period of 15 years.
  • All cases that were histologically diagnosed as salivary gland tumours from January 1990 to December 2004 were retrieved from the histopathology records of the Department of Oral Pathology and Biology and Department of Oral and Maxillofacial Surgery of the Lagos University Teaching Hospital, Lagos, Nigeria.
  • All the cases were subjected to analysis of age, sex, site of occurrence and histologic diagnosis based on 1991 World Health Organisation (WHO) classification.
  • Salivary gland constituted 6.3% of all oro-facial tumours and tumour-like lesions.
  • Minor salivary glands (63.3%) were mostly affected.
  • Pleomorphic adenoma was the most commonly occurring tumour (29.2%) followed by adenoid cystic carcinoma (19.2%).
  • The predominant benign and malignant tumours were pleomorphic adenoma and adenoid cystic carcinoma respectively.
  • The incidence of salivary gland tumours in this study is higher than in most previous reports.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenoma, Pleomorphic / epidemiology. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Child. Female. Hospitals, Teaching. Hospitals, University. Humans. Male. Middle Aged. Nigeria / epidemiology

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  • (PMID = 18564644.001).
  • [ISSN] 0309-3913
  • [Journal-full-title] African journal of medicine and medical sciences
  • [ISO-abbreviation] Afr J Med Med Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Nigeria
  • [Number-of-references] 25
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69. Vékony H, Ylstra B, Wilting SM, Meijer GA, van de Wiel MA, Leemans CR, van der Waal I, Bloemena E: DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma. Clin Cancer Res; 2007 Jun 1;13(11):3133-9
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  • [Title] DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma.
  • PURPOSE: Adenoid cystic carcinoma (ACC) is a malignant salivary gland tumor with a high mortality rate due to late, distant metastases.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. DNA, Neoplasm / metabolism. Gene Expression Regulation, Neoplastic. Intercellular Signaling Peptides and Proteins / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 17545515.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Intercellular Signaling Peptides and Proteins; 0 / Platelet-Derived Growth Factor; 62031-54-3 / Fibroblast Growth Factors; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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70. Vékony H, Raaphorst FM, Otte AP, van Lohuizen M, Leemans CR, van der Waal I, Bloemena E: High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma. J Clin Pathol; 2008 Jun;61(6):744-9
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  • [Title] High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma.
  • BACKGROUND: The prognosis of adenoid cystic carcinoma (ACC), a malignant salivary gland tumour, depends on clinicopathological parameters.
  • RESULTS: ACC revealed significantly increased expression of the cell cycle proteins compared to normal salivary tissue (n = 17).
  • Members of the two PcG complexes displayed mutually exclusive expression in normal salivary gland tissue, with BMI-1 and MEL-18 being abundantly present.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. DNA-Binding Proteins / analysis. Salivary Gland Neoplasms / chemistry. Transcription Factors / analysis

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  • (PMID = 18326020.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Transcription Factors; EC 2.1.1.43 / EZH2 protein, human; EC 2.1.1.43 / Polycomb Repressive Complex 2
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71. Vargas PA, Torres-Rendon A, Speight PM: DNA ploidy analysis in salivary gland tumours by image cytometry. J Oral Pathol Med; 2007 Jul;36(6):371-6
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  • [Title] DNA ploidy analysis in salivary gland tumours by image cytometry.
  • AIM: To determine whether DNA ploidy by image cytometry is a good diagnostic tool to distinguish benign and malignant salivary gland tumours.
  • METHODS: A total of 62 salivary gland tumours were studied.
  • According to the World Health Organization (WHO) classification, there were 14 mucoepidermoid carcinomas (MEC), 11 adenoid cystic carcinomas (ACC), 10 pleomorphic adenomas (PA), 10 carcinoma ex PA (CEPA), 9 acinic cell carcinomas (ACCa), 3 polymorphous low-grade adenocarcinomas (PLGA), 2 papillary cystadenocarcinomas (PC), 1 myoepithelial carcinoma (MC), 1 undifferentiated carcinoma (UC) and 1 mucinous adenocarcinoma (MA).
  • RESULTS: Fifty-three of 62 salivary gland tumours were uniformly diploid.
  • CONCLUSIONS: The vast majority of salivary gland tumours were diploid.
  • [MeSH-major] DNA, Neoplasm / analysis. Image Cytometry. Ploidies. Salivary Gland Neoplasms / genetics

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  • (PMID = 17559500.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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72. Zhao JF, Li XM, Xie WH, Wang HB, Fang Z, Li QC: [Effect and mechanism of matrine on adhesion and invasion of salivary gland adenoid cystic carcinoma cells in vitro]. Shanghai Kou Qiang Yi Xue; 2009 Aug;18(4):401-5
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  • [Title] [Effect and mechanism of matrine on adhesion and invasion of salivary gland adenoid cystic carcinoma cells in vitro].
  • PURPOSE: To investigate the effect and mechanism of matrine on adhesion and invasion of human adenoid cystic carcinoma ACC-M cells in vitro.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Cell Line, Tumor
  • [MeSH-minor] Alkaloids. Cell Adhesion. Humans. In Vitro Techniques. Quinolizines. Salivary Gland Neoplasms. Salivary Glands

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  • (PMID = 19760015.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Alkaloids; 0 / Quinolizines; 519-02-8 / matrine
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73. Nepal A, Chettri ST, Joshi RR, Bhattarai M, Ghimire A, Karki S: Primary salivary gland tumors in eastern Nepal tertiary care hospital. J Nepal Health Res Counc; 2010 Apr;8(1):31-4
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  • [Title] Primary salivary gland tumors in eastern Nepal tertiary care hospital.
  • BACKGROUND: The knowledge of the distribution and pattern of salivary gland tumors in the tertiary care center can provide overview of the disease pattern in the region.
  • METHODS: A retrospective observational study of all the salivary gland tumors treated in the department of Otolaryngology, B. P.
  • Pleomorphic adenoma was the commonest tumor (76%) of all primary salivary gland tumors.
  • Adenoid cystic carcinoma (40%) and mucoepidermoid carcinoma (30%) were commonest malignant tumors.
  • CONCLUSIONS: The principal site for salivary gland tumors in eastern Nepal population was the parotid and the pleomorphic adenoma outnumbered all other tumors.
  • [MeSH-major] Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Middle Aged. Nepal. Parotid Gland / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Retrospective Studies. Salivary Glands / pathology. Young Adult

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  • (PMID = 21879011.001).
  • [ISSN] 1999-6217
  • [Journal-full-title] Journal of Nepal Health Research Council
  • [ISO-abbreviation] J Nepal Health Res Counc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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74. Li Y, Li LJ, Huang J, Han B, Pan J: Central malignant salivary gland tumors of the jaw: retrospective clinical analysis of 22 cases. J Oral Maxillofac Surg; 2008 Nov;66(11):2247-53
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  • [Title] Central malignant salivary gland tumors of the jaw: retrospective clinical analysis of 22 cases.
  • PURPOSE: As a review of central malignant salivary gland tumor cases in Southwest China in the past 20 years, this study provided the clinical, radiologic, and pathologic information of these rare lesions.
  • PATIENTS AND METHODS: In our study, 22 cases of central malignant salivary gland tumor treated between 1986 to 2006 at West China Stomatology Hospital of Sichuan University were retrospectively analyzed.
  • A thorough review of clinical records was carried out and the histologic diagnosis was revised using the 2005 WHO criteria.
  • The most frequent histologic type was the mucoepidermoid carcinoma.
  • CONCLUSION: Central malignant salivary gland tumors often occurred in the middle-aged patients, and there were more cases in the mandible than in the maxilla.
  • The diagnosis should be based on the case history, clinical, pathologic, and radiologic examinations.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Jaw Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Carcinoma / pathology. Carcinoma / radiography. Carcinoma / surgery. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / radiography. Carcinoma, Adenoid Cystic / surgery. China. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 18940488.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Gbotolorun OM, Arotiba GT, Effiom OA, Omitola OG: Minor salivary gland tumours in a Nigerian hospital: a retrospective review of 146 cases. Odontostomatol Trop; 2008 Sep;31(123):17-23
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  • [Title] Minor salivary gland tumours in a Nigerian hospital: a retrospective review of 146 cases.
  • PURPOSE: This is a retrospective study of the location, diagnosis, sex and age distribution and treatment of minor salivary glands tumours of the upper aero digestive tract in Lagos, Nigeria.
  • RESULTS: These tumours constituted 40.4% of all salivary gland tumours in the series.
  • The majority (62.3%) of these tumours was malignant, and the most common malignant tumour was mucoepidermoid carcinoma (19.2%).
  • Patients with adenoid cystic carcinoma were significantly older at presentation than those with pleomorphic adenoma and adenocarcinoma (P < 0.05).
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Mucoepidermoid / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age Factors. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Nigeria. Palatal Neoplasms / pathology. Retrospective Studies. Sex Distribution. Young Adult

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  • (PMID = 19266846.001).
  • [ISSN] 0251-172X
  • [Journal-full-title] Odonto-stomatologie tropicale = Tropical dental journal
  • [ISO-abbreviation] Odontostomatol Trop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Senegal
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81. Reichart PA, Kalz S, Rabel A, Bornstein MM: Carcinoma ex pleomorphic adenoma in a minor salivary gland: report of a case. Oral Maxillofac Surg; 2010 Mar;14(1):59-62
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  • [Title] Carcinoma ex pleomorphic adenoma in a minor salivary gland: report of a case.
  • BACKGROUND: Carcinoma ex pleomorphic adenoma is exceedingly rare in minor salivary glands of the oral cavity.
  • We present a case of carcinoma ex pleomorphic adenoma (CEPA) of the buccal mucosa in a 47-year-old Turkish patient.
  • Pleomorphic adenoma was the tentative diagnosis.
  • Histopathologic evaluation revealed a preexisting pleomorphic adenoma associated with adenoid tumor component with tubulo-cystic and papillary or pseudopapillary structures; CEPA was diagnosed.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 19816723.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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82. Vargas PA, Cheng Y, Barrett AW, Craig GT, Speight PM: Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours. J Oral Pathol Med; 2008 May;37(5):309-18
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  • [Title] Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours.
  • BACKGROUND: Recent studies have proposed that minichromosome maintenance (Mcm) proteins may be sensitive proliferation markers and may serve as novel biomarkers for prognostication and diagnosis of various pre-malignant and malignant lesions.
  • The aims of this study were to determine the expression of Mcm-2, Ki-67 and geminin in salivary gland (SG) tumours, and to evaluate their usefulness for diagnosis or for prediction of tumour behaviour.
  • There were 13 adenoid cystic carcinomas (ACC), 10 carcinoma ex pleomorphic adenomas (CEPA), 10 mucoepidermoid carcinomas (MEC), 10 polymorphous low-grade adenocarcinomas (PLGA), 10 pleomorphic adenomas (PA) and nine acinic cell carcinomas (AcCC).
  • CONCLUSIONS: The findings suggest that Mcm-2 may be a sensitive proliferation marker in SG tumours and may be useful for differential diagnosis between PA and CEPA, and ACC and PLGA.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Cell Cycle Proteins / biosynthesis. Ki-67 Antigen / biosynthesis. Nuclear Proteins / biosynthesis. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Acinar Cell / diagnosis. Carcinoma, Acinar Cell / metabolism. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Cell Proliferation. Diagnosis, Differential. Female. Geminin. Humans. Immunoenzyme Techniques. Male. Microarray Analysis. Middle Aged. Minichromosome Maintenance Complex Component 2. Neoplasm Proteins / biosynthesis

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  • (PMID = 18248354.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / GMNN protein, human; 0 / Geminin; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2
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83. Ahmed MM, Abo-Hager EA: Differential expression of c-kit and CD43 in histological subtypes of adenoid cystic carcinoma of salivary gland. Saudi Dent J; 2010 Jan;22(1):27-34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of c-kit and CD43 in histological subtypes of adenoid cystic carcinoma of salivary gland.
  • Adenoid cystic carcinoma (ACC) of the salivary gland is characterized by a prolonged but inevitably unfavorable clinical course.
  • CD43 appears to be preferentially expressed in salivary gland ACCs.
  • Its expression decreased with cellular dedifferentiation and there was an inverse relationship between immunoexpression of c-kit and CD43 among ACC of salivary gland.

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  • (PMID = 23960476.001).
  • [ISSN] 1013-9052
  • [Journal-full-title] The Saudi dental journal
  • [ISO-abbreviation] Saudi Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3723079
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma (ACC) / CD43 / Immunohistochemistry / Salivary gland / c-kit
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84. Greer RO Jr, Said S, Shroyer KR, Marileila VG, Weed SA: Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma. Oral Oncol; 2007 Sep;43(8):735-41
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  • [Title] Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma.
  • Adenoid cystic carcinoma (ACC) of the salivary glands exhibits persistent growth, invasion and metastasis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Cortactin / metabolism. Cyclin D1 / metabolism. Neoplasm Proteins / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17113340.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE014364; United States / NIDCR NIH HHS / DE / DE014578
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTTN protein, human; 0 / Cortactin; 0 / Neoplasm Proteins; 136601-57-5 / Cyclin D1
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85. Perez DE, Magrin J, de Almeida OP, Kowalski LP: Multiple cutaneous metastases from a parotid adenoid cystic carcinoma. Pathol Oncol Res; 2007;13(2):167-9
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  • [Title] Multiple cutaneous metastases from a parotid adenoid cystic carcinoma.
  • Cutaneous metastasis from salivary gland adenoid cystic carcinoma is extremely rare.
  • We report a case of a 39-year-old man that presented multiple cutaneous metastases from a parotid salivary gland adenoid cystic carcinoma.
  • This case shows the importance of a detailed and periodical skin examination in patients treated for salivary gland adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Parotid Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 17607381.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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86. Adeyemi BF, Kolude BM, Akang EE, Lawoyin JO: A study of the utility of silver nucleolar organizer regions in categorization and prognosis of salivary gland tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Oct;102(4):513-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A study of the utility of silver nucleolar organizer regions in categorization and prognosis of salivary gland tumors.
  • BACKGROUND: this study aimed at assessing the utility of silver nucleolar organizer region (AgNOR) staining in categorization and prognostication of salivary gland tumors.
  • METHODS: Twenty-seven malignant salivary gland tumors, 16 benign neoplasms, and 6 chronic sialadenitis lesions were stained using the technique described by Ploton et al. (1986).
  • In addition, no correlation was found between mean AgNOR counts and the clinical course of malignant or benign salivary gland neoplasms.
  • CONCLUSION: Our results suggest that AgNOR staining is useful for distinguishing benign from malignant lesions, but is neither helpful for discriminating between histological types and grades of malignant neoplasms, nor prognostication of malignant salivary gland neoplasms.
  • [MeSH-major] Nucleolus Organizer Region / pathology. Salivary Gland Neoplasms / pathology. Silver Staining
  • [MeSH-minor] Adenocarcinoma / pathology. Adolescent. Adult. Aged. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Sialadenitis / pathology

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  • [CommentIn] Future Oncol. 2007 Feb;3(1):49-53 [17280501.001]
  • (PMID = 16997120.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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87. Jaber MA: Intraoral minor salivary gland tumors: a review of 75 cases in a Libyan population. Int J Oral Maxillofac Surg; 2006 Feb;35(2):150-4
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  • [Title] Intraoral minor salivary gland tumors: a review of 75 cases in a Libyan population.
  • Minor salivary gland carcinomas are uncommon but most often occur in the oral cavity, particularly the hard palate.
  • During the period of 1977-2000 a group of 75 patients (31 males and 44 females, median age 44.2 years and range 15-86 years) with minor salivary gland tumors were diagnosed, based on the 1991 WHO classification.
  • Pleomorphic adenoma was the most common histological type of benign tumor identified whereas mucoepidermoid carcinoma and adenoid cystic carcinoma were the most common malignant tumors.
  • This study shows that intraoral tumors of minor salivary glands vary widely in presentation, and should be taking into account by medical and dental practitioners in any differential diagnosis when assessing intraoral pathology.
  • Any lesion arising from the hard palate (the most common site in this series) should be considered as a possible minor salivary gland tumor.
  • Referral to a multidisciplinary head and neck clinic following diagnosis is strongly recommended.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor

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  • (PMID = 16181771.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 36
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88. Farrell T, Chang YL: Basal cell adenocarcinoma of minor salivary glands. Arch Pathol Lab Med; 2007 Oct;131(10):1602-4
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  • [Title] Basal cell adenocarcinoma of minor salivary glands.
  • Basal cell adenocarcinoma of minor salivary glands is a relatively rare slow-growing tumor with an infiltrating growth pattern.
  • The infiltrating growth pattern and likelihood of vascular and perineural involvement distinguishes basal cell adenocarcinoma from basal cell adenoma.
  • Other diagnostic considerations include adenoid cystic carcinoma and basaloid squamous carcinoma.
  • It is necessary to differentiate basal cell adenocarcinoma from other basaloid cell tumors of the minor salivary glands because of the prognosis and potential differences in treatment, particularly adenoid cystic adenocarcinoma and basaloid squamous carcinoma.
  • Surgical excision with a wide margin to ensure complete removal has been suggested as the primary treatment for basal cell adenocarcinoma.
  • Radiotherapy has been proposed for lesions in the minor salivary glands because of the higher likelihood of vascular and neural invasion and for those that are diffusely infiltrative.
  • [MeSH-major] Adenocarcinoma / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Squamous Cell / diagnosis. Combined Modality Therapy. Diagnosis, Differential. Humans

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  • (PMID = 17922602.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Vila L, Liu H, Al-Quran SZ, Coco DP, Dong HJ, Liu C: Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland. Mod Pathol; 2009 Oct;22(10):1296-302
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.
  • The CD117 (KIT) protein is overexpressed in many human neoplasms including adenoid cystic carcinoma of salivary glands.
  • To evaluate the function of c-kit-activating mutations in adenoid cystic carcinoma of the salivary gland, we studied 14 cases (13 primary, 1 cervical lymph node metastasis) from our institution.
  • This study is the first to report c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.
  • Identification of such potential gain-of-function mutations in exon 11, and less frequently in exons 9, 13 and 17, suggests that KIT may be involved in the pathogenesis of adenoid cystic carcinoma of salivary glands.
  • Our study raises a prospect of correlation of c-kit mutation and a potential treatment of adenoid cystic carcinoma with tyrosine kinase inhibitor (imatinib).

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  • (PMID = 19617878.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK002958; United States / NIDDK NIH HHS / DK / DK02958
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Other-IDs] NLM/ NIHMS490200; NLM/ PMC3746033
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90. Chakrabarti S, Bera M, Bhattacharya PK, Chakrabarty D, Manna AK, Pathak S, Maiti K: Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry. J Indian Med Assoc; 2010 Dec;108(12):833-6
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  • [Title] Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry.
  • Salivary gland swelling is a common and important problem.
  • Acute and chronic sialadenitis, different benign and malignant neoplasms are the common causes which present with salivary gland swelling.
  • Imaging technique is not so helpful in pre-operative diagnosis; microscopical examination is required for diagnosis.
  • The study was done with 40 cases of salivary gland swelling.
  • Out of 40 cases, 25 involved the parotid gland, most common age group affected was 20 - 40 years and male: female ratio was 5: 3.
  • Among these 3 cases, 2 were adenoid cystic carcinoma which was cytologically diagnosed as benign neoplasm (monomorphic adenoma).
  • FNAC is an important tool for early diagnosis of salivary gland lesions.
  • [MeSH-major] Biopsy, Fine-Needle. Salivary Gland Diseases / pathology

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  • (PMID = 21661459.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] India
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91. Liu X, Zhang Y, Ren W, Cao T, Zhu Y: RNAi knockdown of C-erbB2 expression inhibits salivary gland adenoid cystic carcinoma SACC-83 cell growth in vitro. J Biomed Res; 2010 May;24(3):215-22
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  • [Title] RNAi knockdown of C-erbB2 expression inhibits salivary gland adenoid cystic carcinoma SACC-83 cell growth in vitro.
  • OBJECTIVE: To knockdown the C-erbB2 gene in salivary gland adenoid cystic carcinoma SACC-83 cells using RNA interference, and determine the effect of silencing C-erbB2 on cell proliferation.
  • RESULTS: Compared with the control, C-erbB2 mRNA expression was decreased in the C-erbB2-siRNA transfection group, and immunohistochemical analysis indicated that C-erbB2 protein expression was decreased.
  • The differences were statistically significant (P < 0.05) between the C-erbB2-siRNA group and the control groups.
  • Following the C-erbB2 knockdown, the percentage of apoptotic cells was 5.63% compared with 2.04%, 2.85%, and 2.98% in the three control groups, respectively.
  • CONCLUSION: RNA interference can effectively silence C-erbB2 gene expression and inhibit growth of SACC-83 cells, which indicates the potential of targeting this gene as a novel gene therapy approach for the treatment of salivary gland adenoid cystic carcinoma.

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  • (PMID = 23554633.001).
  • [ISSN] 1674-8301
  • [Journal-full-title] Journal of biomedical research
  • [ISO-abbreviation] J Biomed Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3596557
  • [Keywords] NOTNLM ; C-erbB2 / RNA interference / gene silence / salivary gland adenoid cystic carcinoma
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92. Attlmayr B, Garrido C, Alderson DJ: Difficulty in establishing a diagnosis in an uncommon presentation of a minor salivary gland tumour. BMJ Case Rep; 2010;2010
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Difficulty in establishing a diagnosis in an uncommon presentation of a minor salivary gland tumour.
  • We report the case of a man presenting with a large, airway obstructing, minor salivary gland tumour arising from the right tonsillar base.
  • A firm diagnosis of malignancy could not be made histologically.
  • The differential diagnosis included polymorphous low-grade adenocarcinoma, basal cell adenoma and adenoid cystic carcinoma.
  • However, on balance, based on the clinical presentation, a diagnosis of malignancy was favoured and appropriate treatment was considered.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / pathology. Airway Obstruction / etiology. Deglutition Disorders / etiology. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Cooperative Behavior. Diagnosis, Differential. Endoscopy. Humans. Interdisciplinary Communication. Lymphatic Metastasis / pathology. Lymphatic Metastasis / radiotherapy. Magnetic Resonance Imaging. Male. Middle Aged. Palliative Care. Tongue / pathology. Tracheostomy

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  • (PMID = 22798299.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC3029651
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93. Zhang J, Peng B: NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro. Cell Prolif; 2009 Apr;42(2):150-61
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  • [Title] NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro.
  • Tumour cell-derived angiogenic-related factors and endothelial cell mobility are essential for neovascularization and haematogenous metastasis of adenoid cystic carcinoma (ACC) of the human salivary glands.
  • CONCLUSIONS: Our results suggest that NF-kappaB promotes iNOS and VEGF expression in salivary gland ACC cells and enhances endothelial cell motility in vitro.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Cell Movement / physiology. Endothelial Cells / cytology. NF-kappa B / physiology. Nitric Oxide Synthase Type II / metabolism. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Cell Line. Cell Line, Tumor / drug effects. Cell Proliferation / drug effects. Culture Media, Conditioned / pharmacology. Gene Expression / drug effects. Humans. I-kappa B Proteins / genetics. I-kappa B Proteins / metabolism. Lipopolysaccharides / pharmacology. Mutation / physiology. NF-kappa B p50 Subunit / metabolism. Neovascularization, Physiologic / drug effects. Neovascularization, Physiologic / physiology. Nitrites / metabolism. Salivary Gland Neoplasms / metabolism. Transcription Factor RelA / metabolism. Transfection

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  • (PMID = 19317804.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Culture Media, Conditioned; 0 / I-kappa B Proteins; 0 / Lipopolysaccharides; 0 / NF-kappa B; 0 / NF-kappa B p50 Subunit; 0 / Nitrites; 0 / Transcription Factor RelA; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 139874-52-5 / NF-kappaB inhibitor alpha; EC 1.14.13.39 / NOS2 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase Type II
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94. Zhang J, Peng B: In vitro angiogenesis and expression of nuclear factor kappaB and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma. BMC Cancer; 2007;7:95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In vitro angiogenesis and expression of nuclear factor kappaB and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma.
  • BACKGROUND: Adenoid cystic carcinoma is a high malignant carcinoma characterized by intensive local invasion and high incidence of distant metastasis.
  • Although many reports have demonstrated that angiogenesis has played an important role in tumor metastasis, the relationship between metastasis characters and angiogenesis ability in high and low metastasis cell lines of Adenoid cystic carcinoma has rarely been reported.
  • [MeSH-major] Carcinoma, Adenoid Cystic / blood supply. Carcinoma, Adenoid Cystic / secondary. Neovascularization, Pathologic / pathology. Salivary Gland Neoplasms / blood supply. Transcription Factor RelA / metabolism. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 17543095.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Transcription Factor RelA; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
  • [Other-IDs] NLM/ PMC1903362
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95. Negahban S, Daneshbod Y, Khademi B, Seif I: Papillary cystic acinic cell carcinoma with many psammoma bodies, so-called psammoma body-rich papillary cystic acinic cell carcinoma: report of a case with fine needle aspiration findings. Acta Cytol; 2009 Jul-Aug;53(4):440-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary cystic acinic cell carcinoma with many psammoma bodies, so-called psammoma body-rich papillary cystic acinic cell carcinoma: report of a case with fine needle aspiration findings.
  • Psammoma bodies are infrequent in salivary gland aspirates.
  • We present a case of papillary cystic acinic cell carcinoma with many psammoma bodies and discuss the diagnostic pitfalls with other salivary gland tumors.
  • Sonography showed a 2-cm, cystic mass in the left parotid.
  • A preliminary diagnosis of papillary cystic salivary gland neoplasm was made and supeficial parotidectomy performed.
  • A diagnosis of papillary cystic acinic cell carcinoma with many psammoma bodies was made.
  • Aspiration cytology of papillary cystic acinic cell carcinoma with many psammoma bodies can be confused with more common tumors, such as cystic mixed tumor and adenoid cystic carcinoma with cannonballs, low grade mucoepidermoid carcinoma or cystic papillary carcinoma of the thyroid.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Carcinoma, Papillary / pathology. Diagnosis, Differential. Female. Humans

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  • (PMID = 19697733.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Ethunandan M, Davies B, Pratt CA, Puxeddu R, Brennan PA: Primary epithelial submandibular salivary gland tumours--review of management in a district general hospital setting. Oral Oncol; 2009 Feb;45(2):173-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary epithelial submandibular salivary gland tumours--review of management in a district general hospital setting.
  • Primary epithelial submandibular gland (SMG) tumours are uncommon, accounting for 8-12% of all salivary gland neoplasms, and most studies come from large specialised centres.
  • Pleomorphic adenoma accounted for all 17 benign tumours and adenoid cystic carcinoma was the commonest malignant tumour.
  • [MeSH-major] Neoplasms, Glandular and Epithelial / diagnosis. Submandibular Gland Neoplasms / diagnosis

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  • (PMID = 18676173.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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97. Zhao DM, He HW, Liu MY, He ZX: [Tumors of different histological type in unilateral salivary glands: a case report]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2010 Dec;28(6):680-1, 683

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumors of different histological type in unilateral salivary glands: a case report].
  • Tumors of synchronous benign and malignant in unilateral salivary glands have rarely been reported.
  • A case of 21-year-old girl who was diagnosed as synchronously adenoid cystic carcinoma of the left parotid and pleomorphic adenoma of the left submandibular gland.
  • The classification, clinic pathology, diagnosis, possible mechanism were discussed based on similar literatures.
  • [MeSH-major] Adenoma, Pleomorphic. Carcinoma, Adenoid Cystic
  • [MeSH-minor] Female. Humans. Salivary Glands. Young Adult

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  • (PMID = 21365854.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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98. Götte K, Ganssmann S, Affolter A, Schäfer C, Riedel F, Arens N, Finger S, Hörmann K: Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses. Oncol Rep; 2005 Nov;14(5):1103-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses.
  • To date, the underlying genomic changes in benign and malignant tumors of salivary-gland and paranasal-sinus origin are poorly understood.
  • We examined 58 of these tumors (14 adenoid cystic carcinomas, 9 adenocarcinomas, 5 cylindrical carcinomas, 11 pleomorphic adenomas, and 19 inverted papillomas) by dual fluorescence in situ hybridization (FISH) with centromere-specific probes on six chromosomes (3, 7, 9, 11, 17, and 18) for numerical changes.
  • In adenoid cystic carcinomas, monosomy of chromosome 17 and polysomy of chromosomes 3, 9 and 11 were most frequently encountered.
  • In summary, the occurrence of polysomy might reflect a step towards malignancy in tumors of the salivary glands and paranasal mucosa.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. Adenoma / diagnosis. Adenoma / genetics. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / genetics. Chromosome Aberrations. Papilloma / diagnosis. Papilloma / genetics. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Diagnosis, Differential. Humans. In Situ Hybridization, Fluorescence. Salivary Gland Diseases / diagnosis. Salivary Gland Diseases / genetics

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  • (PMID = 16211271.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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99. Bandyopadhyay A, Das TK, Raha K, Hati GC, Mitra PK, Dasgupta A: A study of fine needle aspiration cytology of salivary gland lesions with histopathological corroboration. J Indian Med Assoc; 2005 Jun;103(6):312-4, 316
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A study of fine needle aspiration cytology of salivary gland lesions with histopathological corroboration.
  • The diagnostic utility of fine needle aspiration cytology as initial work up of salivary gland enlargement was assessed in one hundred and eighty-five salivary gland specimens over three years period and corroborated with histopathology, whenever feasible.
  • All smears were evaluated according to cell size, amount of cytoplasm, cytologic atypia and presence of lymphocytes. (a) Variable cytologic appearances of pleomorphic salivary adenoma were observed. (b) Cellular pleomorphic adenoma and adenoid cystic carcinoma showed basaloid cell features. (c) Tumours with intermediate size cells and bland cytology included low grade muco-epidermoid carcinoma and cystic lesions. (d) Warthin's tumour, oncocytoma, salivary duct carcinoma and high grade muco-epidermoid carcinoma revealed large cells and abundant cytoplasm with or without atypia.
  • A major diagnostic categories were inflammatory lesions (n = 7 5), cystic lesions (n = 9), benign tumours (n = 81), malignant neoplasms (n = 1 8) and normal acinar pattern (n = 2).
  • Malignant tumours included muco-epidermoid carcinoma (n = 5), adenoid cystic carcinoma (n = 3), acinic cell carcinoma (n = 2), adenocarcinoma (n= 2), squamous cell carcinoma (n = 1), undifferentiated carcinoma (n= 4) and malignant lymphoma (n = 1).
  • So it can be concluded that fine needle aspiration cytology can play important role in early diagnosis and subsequent therapeutic planning of salivary gland lesions.
  • [MeSH-major] Adenoma / pathology. Salivary Gland Neoplasms / pathology. Sialadenitis / pathology

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  • (PMID = 16225156.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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100. Tan Z, Ling ZQ, Chen C, Xu JJ, Ge MH: [Evolution pattern of the Runx3 gene 5'-CpG island methylation in human salivary gland adenoid cystic carcinoma]. Zhonghua Zhong Liu Za Zhi; 2010 Dec;32(12):907-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Evolution pattern of the Runx3 gene 5'-CpG island methylation in human salivary gland adenoid cystic carcinoma].
  • OBJECTIVE: To investigate the evolution pattern of the Runx3 gene 5'-CpG island ~3478 bp region methylation in human salivary gland adenoid cystic carcinoma (SGACC).
  • METHODS: Quantitative MSP method was used to detect the methylation status of CpG island in various regions (No.1-10) of Runx3 promoter region, and Western blot was used for detection of the expression of Runx3 protein in 41 salivary gland SGACC samples and corresponding non-neoplastic salivary gland tissues.
  • A Logistic model was used to analyze the risk ratio between the methylation status of CpG island in Runx3 gene and development of salivary SGACC, meanwhile, the possible association among the methylation of Runx3 gene, the clinicopathological parameters of SGACCs, and Runx3 protein expression was compared.
  • The methylation rate was highest in region No. 1 and No. 2 among the successive ten regions ranging from the 5' region to the transcription start site within the Runx3 CpG island, and lowest in the transcription start site both in SGACCs and normal salivary glands.
  • Furthermore, there was no methylation in the transcription start site in nomal salivary glands tissues.
  • Western blot results revealed that the Runx3 protein level in SGACC was significantly lower than that in normal salivary glands (P < 0.01).
  • CONCLUSIONS: Methylation of the Runx3 CpG island spreads from the most 5'-region to the transcription start site in human salivary gland adenoid cystic carcinoma, and the transcription start site may be a critical region for the methylation of Runx3.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Core Binding Factor Alpha 3 Subunit / genetics. CpG Islands / genetics. DNA Methylation. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Logistic Models. Male. Middle Aged. Salivary Glands / metabolism

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  • (PMID = 21223798.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 3 Subunit; 0 / Runx3 protein, human
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