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1. Yokouchi H, Otsuka Y, Otoguro Y, Takemoto N, Ito K, Uchida Y, Okamoto K, Nishimura M, Kimura K, Kaji H: Primary peripheral adenoid cystic carcinoma of the lung and literature comparison of features. Intern Med; 2007;46(21):1799-803
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary peripheral adenoid cystic carcinoma of the lung and literature comparison of features.
  • Adenoid cystic carcinoma arising from the peripheral lung is rare.
  • Here, we describe adenoid cystic carcinoma that developed in the peripherally in S(9) of the right lower lobe of an 84-year-old woman.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 17978538.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Kim B: Palliative radiotherapy in a patient with pulmonary adenoid cystic carcinoma. Cancer Res Treat; 2007 Dec;39(4):185-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Palliative radiotherapy in a patient with pulmonary adenoid cystic carcinoma.
  • Primary adenoid cystic carcinoma in the lung is very rare, so its clinicopathologic characteristics have usually been extrapolated from the salivary disease.
  • However, the clinical courses of pulmonary adenoid cystic carcinomas may be different from those of salivary disease, and individual differences may also exist.
  • I report here on a case of a patient who was initially diagnosed as pulmonary adenoid cystic carcinoma with liver metastases and the tumor showed extreme radiosensitivity, but it also underwent an aggressive clinical course.
  • Adenoid cystic carcinoma is usually known to be a slowly growing tumor, but it may rapidly disseminate, like in this patient.
  • Therefore, the factors predicting aggressive behavior should be determined and the treatment might be individualized according to the primary sites and on the patient's basis.

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  • (PMID = 19746187.001).
  • [ISSN] 1598-2998
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2739373
  • [Keywords] NOTNLM ; Prognostic factor / Pulmonary adenoid cystic carcinoma / Radiosensitivity
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3. Aubry MC, Heinrich MC, Molina J, Lewis JE, Yang P, Cassivi SD, Corless CL: Primary adenoid cystic carcinoma of the lung: absence of KIT mutations. Cancer; 2007 Dec 1;110(11):2507-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenoid cystic carcinoma of the lung: absence of KIT mutations.
  • BACKGROUND: Primary pulmonary adenoid cystic carcinomas (ACCs) are rare lung neoplasms that are challenging to completely resect and can exhibit poor survival.
  • METHODS: Primary salivary gland-type tumors of the lung diagnosed between 1972 and 2002 at the Mayo Clinic were identified and the subset of primary pulmonary ACCs were reviewed.
  • RESULTS: Forty-nine patients were diagnosed with primary pulmonary ACC.
  • CONCLUSIONS: Although KIT expression was found frequently in primary pulmonary ACC, a correlation with KIT-activating mutations was not observed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Lung Neoplasms / metabolism. Mutation. Proto-Oncogene Proteins c-kit / genetics. Proto-Oncogene Proteins c-kit / metabolism

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  • (PMID = 17932891.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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4. Shi H, Wang J, Dong F, Wang X, Li H, Hou Y: The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma. BMC Cancer; 2009;9:456
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma.
  • BACKGROUND: Salivary adenoid cystic carcinoma (SACC) is one of the most common malignancies of salivary gland.
  • However, there is rare study of the effect of proteoglycans on the potential metastasis of SACC.In this study, human xylosyltransferase-I (XTLY-I) gene, which catalyzes the rate-limited step of proteoglycans biosynthesis, was knocked down by RNA interference (RNAi) to inhibit the proteoglycans biosynthesis in SACC cell line with high tendency of lung metastasis (SACC-M).
  • The invasion and metastasis of SACC-M-WJ4 cells were detected; the effect of down-regulated proteoglycans on the potential lung metastasis of nude mice was observed, respectively.
  • The reduction of proteoglycans suppressed the adhesion, invasion and metastasis properties of SACC-M cells, and decreased the lung metastasis of SACC-M cells markedly either.
  • [MeSH-major] Carcinoma, Adenoid Cystic / drug therapy. Pentosyltransferases / antagonists & inhibitors. Proteoglycans / antagonists & inhibitors. RNA, Small Interfering / pharmacology. Salivary Gland Neoplasms / drug therapy

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  • (PMID = 20025737.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Proteoglycans; 0 / RNA, Small Interfering; EC 2.4.2.- / Pentosyltransferases; EC 2.4.2.26 / UDP xylose-protein xylosyltransferase
  • [Other-IDs] NLM/ PMC2805682
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5. Kitada M, Ozawa K, Sato K, Hayashi S, Tokusashi Y, Miyokawa N, Sasajima T: Adenoid cystic carcinoma of the peripheral lung: a case report. World J Surg Oncol; 2010;8:74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the peripheral lung: a case report.
  • Adenoid cystic carcinoma of the peripheral lung is a rare entity.
  • We recently encountered a patient with adenoid cystic carcinoma.
  • A 75-year-old woman showed a nodular lesion with 10 mm in diameter in the right upper lung field on chest radiography.
  • The diagnosis was unclear, but lung cancer could not be ruled out.
  • Thoracoscopic biopsy was performed, and intraoperative pathological diagnosis revealed the carcinoma of the lung.
  • Histopathological examination revealed adenoid cystic carcinoma with a characteristic cribriform structure.
  • Immunohistochemical examination revealed that the tumor cells were positive for thyroid transcription factor 1 (TTF-1), this tumor was diagnosed primary ACC of the lung.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Pneumonectomy / methods. Radiography, Thoracic. Thoracic Surgery, Video-Assisted / methods. Tomography, X-Ray Computed

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  • (PMID = 20796281.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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  • [Other-IDs] NLM/ PMC2936894
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6. Masih I, Porter G, Porter S, Clarke R, Sidhu P, Harney J, McCarthy A, Convery R: Primary adenoid cystic carcinoma of the bronchus in a female teenager. BMJ Case Rep; 2010;2010
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenoid cystic carcinoma of the bronchus in a female teenager.
  • Primary adenoid cystic carcinoma (ACC) of the lung is an extremely rare malignant lung neoplasm.
  • ACC of salivary glands of the head and neck, lachrymal glands, breast, skin, vulva and trachea have been frequently reported disease patterns in the literature, but it is unique to see this rare lung tumour in a patient as young as 14 years old.
  • Our report of primary lung ACC in a young girl is a complex case due to young age, a different way of presentation and staging on diagnosis.
  • It has been a quite challenging clinical scenario for the multidisciplinary lung cancer treating team involved in the clinical care.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / analysis. Biopsy, Needle. Chest Pain / etiology. Combined Modality Therapy. Cooperative Behavior. Female. Fluorodeoxyglucose F18. Humans. Interdisciplinary Communication. Lung / pathology. Multimodal Imaging. Neoplasm Staging. Pneumonectomy. Positron-Emission Tomography. Radiotherapy, Adjuvant. Shoulder Pain / etiology. Tomography, X-Ray Computed

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  • (PMID = 22798097.001).
  • [ISSN] 1757-790X
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  • [ISO-abbreviation] BMJ Case Rep
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  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC3027792
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7. Lee JI, Kim YZ, Lee EH, Kim KH: Skull base invasion of adenoid cystic carcinoma of the lacrimal gland : a case report. J Korean Neurosurg Soc; 2008 Oct;44(4):273-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skull base invasion of adenoid cystic carcinoma of the lacrimal gland : a case report.
  • Although adenoid cystic carcinoma (ACC) of the lacrimal gland is a rarely encountered orbital tumor, it invades intracranially more frequently than carcinomas of other glands in the head and neck.
  • Additionally, he received radiotherapy (60 Gy) and adjuvant systemic cisplatin and 5-fluorouracil chemotherapy due to residual tumor in the orbit and systemic metastases (lung, ribs, and spines).

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  • (PMID = 19096692.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2588318
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Metastasis / Prognosis / Skull base
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8. Kumar K, Gopi A, Thabah MM, Hari S, Safaya R, Gupta R, Sharma SK: Unusual lung mass: benign or malignant? Indian J Chest Dis Allied Sci; 2008 Oct-Dec;50(4):365-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual lung mass: benign or malignant?
  • Primary adenoid cystic carcinoma of lung is a rare tumour.
  • Average time that elapses before diagnosis is reported to be two years.
  • We report the case of a patient who remained well inspite of harbouring primary adenoid cystic carcinoma of lung for 15 years.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 19035058.001).
  • [ISSN] 0377-9343
  • [Journal-full-title] The Indian journal of chest diseases & allied sciences
  • [ISO-abbreviation] Indian J Chest Dis Allied Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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9. Mohindroo S, Sharma JS: Metastatic adenoid cystic carcinoma of lung: a case report. Indian J Pathol Microbiol; 2006 Oct;49(4):597-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adenoid cystic carcinoma of lung: a case report.
  • A 48 year old male patient, operated five years back for sub mandibular swelling proved on histopathologic examination to be adenoid cystic carcinoma presented in the ENT department, I. G. medical hospital with pain on both sides of the chest.
  • CT guided FNAC as well as biopsy of the lung lesion was performed.
  • Cytodiagnosis and histopathological examinations revealed features of cribiform type of adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary

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  • (PMID = 17183870.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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10. Chuah KL, Lim KH, Koh MS, Tan HW, Yap WM: Diagnosis of adenoid cystic carcinoma of the lung by bronchial brushing: a case report. Acta Cytol; 2007 Jul-Aug;51(4):563-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis of adenoid cystic carcinoma of the lung by bronchial brushing: a case report.
  • BACKGROUND: A diagnosis of pulmonary adenoid cystic carcinoma on exfoliative cytology specimen is very uncommon.
  • No previous report of the diagnosis has been made on bronchial brushing cytologic material when the procedure preceded a tissue biopsy.
  • Bronchial brushing via bronchoscope was performed, revealing carcinoma cells consistent with an adenoid cystic carcinoma on cytology.
  • A bronchial biopsy and subsequent left upper lobectomy were performed, confirming the diagnosis of adenoid cystic carcinoma of the lung associated with tumor extension to the epithelial surface.
  • CONCLUSION: A diagnosis of bronchial adenoid cystic carcinoma is possible on bronchial brushing.
  • [MeSH-major] Bronchoalveolar Lavage. Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 17718122.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Yu Y, Guo W, Qiu WL, Zhou XJ: [Experimental study of hydroxycamptothecine and theprubicine in the treatment of adenoid cystic carcinoma lung metastases]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2006 May;41(5):291-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Experimental study of hydroxycamptothecine and theprubicine in the treatment of adenoid cystic carcinoma lung metastases].
  • OBJECTIVE: To investigate anticancer effect of hydroxycamptothecine and theprubicine in the treatment of established human adenoid cystic carcinoma (ACC) lung metastasis of nude mice and to determine the best therapy sequence of the two drugs.
  • METHODS: The model of ACC lung metastasis (60 animals) was established by injecting the ACC-M cells into the nude mice from their tail veins.
  • The lung samples were collected and observed after HE staining.
  • The area of metastases and lung tissue were analyzed by the images analysis system.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lung Neoplasms / drug therapy
  • [MeSH-minor] Animals. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Carcinoma, Adenoid Cystic / secretion. Epirubicin / administration & dosage. Female. Humans. Male. Mice. Mice, Nude. Salivary Gland Neoplasms / pathology. Tumor Cells, Cultured

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  • (PMID = 16784612.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 3Z8479ZZ5X / Epirubicin; 67656-30-8 / 10-hydroxycamptothecin; XT3Z54Z28A / Camptothecin
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12. Murinello N, Vitorino ME, Matos C, Correia JM, Lima M, Baptista P, Sena Lino J, Nogueira F: [Recurrent adenoid cystic carcinoma. Review based on a case report]. Rev Port Pneumol; 2009 Jan-Feb;15(1):101-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recurrent adenoid cystic carcinoma. Review based on a case report].
  • [Transliterated title] Carcinoma adenóide quístico recorrente. Revisão a propósito de um caso clínico.
  • The adenoid cystic carcinoma is a malignant epithelial glandular type neoplasia, occurring frequently in the salivary and mammary glands, and rarely in the lung, and is responsible for 0.2% of lung tumours.
  • The authors present a case of a woman with adenoid cystic lung carcinoma diagnosed after investigation of a lung nodule, submitted to surgical resection with curative intention, whose follow -up identified late recurrence, 9 years after surgery.
  • The article reviews clinical and pathological features of lung adenoid cystic carcinoma, as well as therapeutic options, namely for prevention of recurrence.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Lung Neoplasms. Neoplasm Recurrence, Local

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  • (PMID = 19145392.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Portugal
  • [Number-of-references] 10
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13. Daneshbod Y, Modjtahedi E, Atefi S, Bedayat GR, Daneshbod K: Exfoliative cytologic findings of primary pulmonary adenoid cystic carcinom: a report of 2 cases with a review of the cytologic features. Acta Cytol; 2007 Jul-Aug;51(4):558-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Exfoliative cytologic findings of primary pulmonary adenoid cystic carcinom: a report of 2 cases with a review of the cytologic features.
  • BACKGROUND: Adenoid cystic carcinoma is a very rare primary pulmonary neoplasm.
  • Cytologic findings of pulmonary washing and brushing in 2 cases of primary bronchial adenoid cystic carcinoma with special histologic features are described, with an emphasis on some points that have not been reported previously, together with the diagnostic pitfalls.
  • CASES: Two cases of primary adenoid cystic carcinoma of the lung were diagnosed on exfoliative cytology.
  • In case 2, chondromyxoid material and a bimorphic population of tumor cells caused diagnostic confusion with other salivary gland-type tumors of the lung.
  • CONCLUSION: These cases showed characteristic cytologic findings of adenoid cystic carcinoma together with rare findings of intracellular and extracellular inclusionlike bodies, myxochondroid material, bimorphic populations and nuclear molding, which can cause diagnostic confusion with other lung tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lung Neoplasms / pathology

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  • (PMID = 17718121.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Unsal A, Karaman CZ, Kacar F, Sen S: [Atypically located pulmonary adenoid cystic carcinoma: case report]. Tuberk Toraks; 2008;56(2):210-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Atypically located pulmonary adenoid cystic carcinoma: case report].
  • [Transliterated title] Atipik yerleşimli pulmoner adenoid kistik karsinom: Olgu sunumu.
  • Pulmonary adenoid cystic carcinomas typically arise from central extra-pulmonary airways and lung involvement is rare.
  • On the other hand, this entity should be kept in mind because it has a more favorable clinical course compared to the primary lung adenocarcinoma.
  • In this paper; the clinical, radiological and pathological aspects of a 47 years old man with a complaint of chronic cough, who was found to have a mass lesion at upper lobe of right lung and a final diagnosis of primary pulmonary adenoid cystic carcinoma according to transbronchial needle biopsy and pneumonectomy, was presented.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lung Neoplasms / pathology. Pneumonectomy / methods
  • [MeSH-minor] Biopsy, Fine-Needle / methods. Bronchoscopy / methods. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 18701983.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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15. Yamada T, Mouri H, Izumi K, Takeuchi S, Ohtsubo K, Yamashita K, Yasumoto K, Kitamura S, Yano S: [Combined chemotherapy with cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1545-8
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  • [Title] [Combined chemotherapy with cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma].
  • We report a case of a 65-year-old man with metastatic primary cutaneous adenoid cystic carcinoma that was effectively treated by combination chemotherapy with cisplatin (CDDP) plus vinorelbine(VNR).
  • He was given a diagnosis of primary cutaneous adenoid cystic carcinoma with metastatic lesions to multiple lungs and left tibial bone and then given chemotherapy combining CDDP plus VNR as the first treatment in December 2008.
  • By this treatment for six cycles, the lung metastatic tumors gradually reduced on chest CT.
  • We reported the efficacy of combined treatment with CDDP plus VNR for primary cutaneous adenoid cystic carcinoma, because this clinical condition was very rare and the standard treatment has still not been established.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Cisplatin / therapeutic use. Lung Neoplasms / drug therapy. Skin Neoplasms / drug therapy. Vinblastine / analogs & derivatives

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  • (PMID = 20716883.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; Q6C979R91Y / vinorelbine
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16. Iseli TA, Karnell LH, Preston TW, Graham SM, Funk GF, Buatti JM, Gupta AK, Robinson RA, Hoffman HT: Facial nerve sacrifice and radiotherapy in parotid adenoid cystic carcinoma. Laryngoscope; 2008 Oct;118(10):1781-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial nerve sacrifice and radiotherapy in parotid adenoid cystic carcinoma.
  • OBJECTIVES: To evaluate the impact of facial nerve sacrifice and postoperative radiotherapy on the outcome of adenoid cystic carcinoma of the parotid gland.
  • Eleven patients with lung metastases survived an average of 67.8 months after metastases were identified.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Facial Nerve / surgery. Parotid Neoplasms / surgery

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  • (PMID = 18758382.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Caiado A, Moura e Sá J: [Tracheal tumors review--a clinical case of adenoid cystic carcinoma]. Rev Port Pneumol; 2008 Jul-Aug;14(4):527-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tracheal tumors review--a clinical case of adenoid cystic carcinoma].
  • [Transliterated title] Revisão dos tumores da traqueia--a propósito de um caso clínico de tumor adenóide cístico.
  • Their incidence is less than 0.2 per 100 000 inhabitants and 180 times less frequent than lung cancer.
  • The authors report a case of adenoid cystic carcinoma in a 23 year-old woman, non-smoker, with acute clinical inspiratory stridor, where Nd-Yag laser use was extremely important to tracheal permeability as the tumor occupied over 80% of the tracheal lumen and could have led to imminent patient asphyxia.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Tracheal Neoplasms

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  • (PMID = 18622529.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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18. Ko YH, Lee MA, Hong YS, Lee KS, Jung CK, Kim YS, Sun DI, Kim BS, Kim MS, Kang JH: Prognostic factors affecting the clinical outcome of adenoid cystic carcinoma of the head and neck. Jpn J Clin Oncol; 2007 Nov;37(11):805-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors affecting the clinical outcome of adenoid cystic carcinoma of the head and neck.
  • BACKGROUND: Adenoid cystic carcinoma (ACC) is an uncommon tumor, constituting approximately 10% of all head and neck tumors.
  • METHODS: We performed a retrospective study of 42 patients who underwent primary tumor resection or radiotherapy with curative intent and evaluated the clinical parameters, treatment and clinical outcomes.
  • Of the 32 patients in whom recurrence could be evaluated, 18 (56.3%) developed distant metastases, with the lung (72.2%) being the most common site.
  • Perivascular invasion influenced metastasis to the lung with borderline significance (P = 0.053).
  • [MeSH-major] Carcinoma, Adenoid Cystic / mortality. Head and Neck Neoplasms / mortality

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  • (PMID = 18057012.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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19. Lai FY, Zhang Q, Wu QL, Qing J, Cao Y: [Expression and significance of E-cadherin in adenoid cystic carcinoma of the salivary glands]. Ai Zheng; 2007 Sep;26(9):1025-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression and significance of E-cadherin in adenoid cystic carcinoma of the salivary glands].
  • This study was to explore the expression of E-cadherin in adenoid cystic carcinoma of the salivary glands and its correlations to nerve invasion, regional recurrence, distant metastasis and prognosis of this disease.
  • METHODS: The expression of E-cadherin in 55 specimens of adenoid cystic carcinoma of the salivary glands and 20 specimens of normal salivary gland tissue was detected by immunohistochemistry.
  • The positive rate of E-cadherin was significantly higher in normal salivary gland tissues than in adenoid cystic carcinoma tissues (90.0% vs.63.6%, P<0.05).
  • CONCLUSION: E-cadherin expression is down-regulated in adenoid cystic carcinoma of the salivary glands, which is correlated to nerve invasion, regional recurrence and distant metastasis.
  • [MeSH-major] Cadherins / metabolism. Carcinoma, Adenoid Cystic / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Cranial Nerve Neoplasms / pathology. Facial Nerve Diseases / pathology. Female. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Salivary Glands / metabolism. Salivary Glands / surgery. Survival Rate

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  • (PMID = 17927866.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cadherins
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20. Yurut-Caloglu V, Caloglu M, Ozyilmaz F, Saynak M, Cosar-Alas R, Karagol H, Bayir-Angin G, Uzal C: Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature. Med Oncol; 2007;24(4):458-62
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  • [Title] Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature.
  • Adenoid cystic carcinoma is the second most common malignancy of the major and minor salivary glands after mucoepidemoid carcinoma.
  • Skeletal muscle and cutaneous metastases from adenoid cystic carcinoma of the parotid gland are extremely rare.
  • In this case, a 40-year-old man with lung and bone metastases followed by skeletal muscle and cutaneous metastases from adenoid cystic carcinoma of the right parotid gland is presented.
  • [MeSH-major] Bone Neoplasms / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis. Muscle Neoplasms / diagnosis. Parotid Neoplasms / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 17917100.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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21. Lin CH, Yen RF, Jeng YM, Tzen CY, Hsu C, Hong RL: Unexpected rapid progression of metastatic adenoid cystic carcinoma during treatment with imatinib mesylate. Head Neck; 2005 Dec;27(12):1022-7
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  • [Title] Unexpected rapid progression of metastatic adenoid cystic carcinoma during treatment with imatinib mesylate.
  • BACKGROUND: There is a lack of effective treatment for metastatic adenoid cystic carcinoma (ACC), a usually indolent tumor.
  • METHOD: Five patients with lung metastasis were treated in a pilot study with imatinib 400 mg by mouth twice a day.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Carcinoma, Adenoid Cystic / drug therapy. Head and Neck Neoplasms / pathology. Lung Neoplasms / drug therapy. Piperazines / adverse effects. Pyrimidines / adverse effects

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc.
  • (PMID = 16265655.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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22. Wei MH, Tang PZ, Xu ZG, Qi YF, Yin YL: [Clinical analysis of 40 cases with sinonasal adenoid cystic carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 May;44(5):381-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of 40 cases with sinonasal adenoid cystic carcinoma].
  • OBJECTIVE: To study the clinical characters and the mode of treatment, and to analyze the prognosis of patients with sinonasal adenoid cystic carcinoma.
  • METHODS: The clinical data were analyzed retrospectively in 40 patients with sinonasal adenoid cystic carcinoma.
  • The most common site of distant metastasis was lung.
  • CONCLUSIONS: Distant metastasis is an important factor affecting the prognosis of the patients with sinonasal adenoid cystic carcinoma.
  • Combined therapy composed of surgery and radiation was the first choice of treatment to the patients with sinonasal adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Paranasal Sinus Neoplasms / therapy

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  • (PMID = 19567046.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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23. Elkin AD, Jacobs CD: Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases. J Cancer Res Clin Oncol; 2008 Oct;134(10):1151-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases.
  • PURPOSE: Adenoid cystic carcinoma of the salivary gland (ACC-SG) is a slow-growing tumor that is refractory to most chemotherapeutic agents.
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Salivary Gland Neoplasms / drug therapy. Tamoxifen / therapeutic use
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / drug therapy. Toremifene / therapeutic use

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  • (PMID = 18347813.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 094ZI81Y45 / Tamoxifen; 7NFE54O27T / Toremifene
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24. Masuya D, Haba R, Huang CL, Yokomise H: Myoepithelial carcinoma of the lung. Eur J Cardiothorac Surg; 2005 Nov;28(5):775-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myoepithelial carcinoma of the lung.
  • Primary lung carcinomas showing features of salivary gland-type neoplasms are rare.
  • Many are mucoepidermoid carcinomas and adenoid cystic carcinomas.
  • Myoepithelial carcinoma of the lung is extremely rare, and in the WHO classification is classified as 'Others' among carcinomas of the salivary gland.
  • Here we report a resected case of myoepithelial carcinoma of the lung, including details of clinical examination, with a review of previously documented cases.
  • [MeSH-major] Lung Neoplasms / ultrastructure. Myoepithelioma / ultrastructure

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  • (PMID = 16188445.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 5
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25. Xiong T, Zhang Z, Liu BF, Zeng S, Chen Y, Chu J, Luo Q: In vivo optical imaging of human adenoid cystic carcinoma cell metastasis. Oral Oncol; 2005 Aug;41(7):709-15

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In vivo optical imaging of human adenoid cystic carcinoma cell metastasis.
  • A noninvasive, whole-body, real-time fluorescence optical imaging of stable high-level green fluorescent protein (GFP)-expressing human adenoid cystic carcinoma (ACC-M-GFP) was demonstrated for in vivo visualization of metastatic behavior in nude mice.
  • Five-week-old female nude mice were injected with ACC-M-GFP in the primary organ: submandibular gland.
  • Metastases were only visualized by GFP expression in the lung.
  • However, metastatic lesions of ACC-M-GFP in the lung, muscle, bladder and bony were found by imaging of GFP expression in intact mice through tail vein injection of ACC-M-GFP cells.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Carcinoma, Squamous Cell / secondary. Green Fluorescent Proteins. Luminescent Agents
  • [MeSH-minor] Animals. Cell Proliferation. Female. Lung Neoplasms / secondary. Mice. Mice, Inbred BALB C. Mice, Nude. Microscopy, Fluorescence. Neoplasm Transplantation

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  • (PMID = 15935724.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Luminescent Agents; 147336-22-9 / Green Fluorescent Proteins
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26. Campistron M, Rouquette I, Courbon F, Chabbert V, Rochaix P, Prévot G, Laroumagne S, Têtu L, Didier A, Mazières J: Adenoid cystic carcinoma of the lung: interest of 18FDG PET/CT in the management of an atypical presentation. Lung Cancer; 2008 Jan;59(1):133-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the lung: interest of 18FDG PET/CT in the management of an atypical presentation.
  • Adenoid cystic carcinoma (ACC) is a common head and neck tumor originating from salivary glands but that can also exceptionally develop in the trachea and major bronchi.
  • We here report for the first time a case of lung ACC with a synchronous liver metastasis proved by biopsy.
  • Moreover, we report the interest of performing a 18FDG PET-CT as both primary tumor and liver metastasis presented an intense FDG uptake.
  • We propose that 18FDG PET-CT should be considered in the initial staging of lung ACC in selected patients.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radionuclide imaging. Fluorodeoxyglucose F18. Lung Neoplasms / radionuclide imaging

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  • (PMID = 17640764.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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27. Braze AJ, Collier ME, Gattuso P, Kim AW: Thoracoscopic management including lobectomy for a primary peripheral pulmonary adenoid cystic carcinoma in a cirrhotic patient. Surg Laparosc Endosc Percutan Tech; 2010 Oct;20(5):e179-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thoracoscopic management including lobectomy for a primary peripheral pulmonary adenoid cystic carcinoma in a cirrhotic patient.
  • Primary peripheral adenoid cystic carcinoma is a relatively rare type of lung carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Liver Cirrhosis / complications. Lung Neoplasms / surgery. Pneumonectomy / methods. Thoracoscopy / methods

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  • (PMID = 20975497.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Shimizu J, Oda M, Matsumoto I, Arano Y, Ishikawa N, Minato H: Clinicopathological study of surgically treated cases of tracheobronchial adenoid cystic carcinoma. Gen Thorac Cardiovasc Surg; 2010 Feb;58(2):82-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological study of surgically treated cases of tracheobronchial adenoid cystic carcinoma.
  • Between 1980 and 2007, five patients were pathologically diagnosed as tracheobronchial adenoid cystic carcinoma (ACC).
  • Four tumors were located in the larger airways, and one tumor was located in the peripheral lung.
  • The best local treatment for ACC of the major airway is considered to be sleeve resection of the trachea or bronchus in an area where airway reconstruction may not be disturbed and to add postoperative irradiation when there is residual carcinoma at the stump.
  • [MeSH-major] Bronchial Neoplasms / surgery. Carcinoma, Adenoid Cystic / surgery. Pulmonary Surgical Procedures. Tracheal Neoplasms / surgery

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  • (PMID = 20155344.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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29. Demirci H, Vine AK, Elner VM: Choroidal metastasis from submandibular salivary gland adenoid cystic carcinoma. Ophthalmic Surg Lasers Imaging; 2008 Jan-Feb;39(1):57-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Choroidal metastasis from submandibular salivary gland adenoid cystic carcinoma.
  • A case of choroidal metastasis from an adenoid cystic carcinoma ofsubmandibular salivary gland is described.
  • A choroidal biopsy was consistent with metastatic adenoid cystic carcinoma from her submandibular salivary gland treated 5 years previously.
  • She was treated with external beam radiotherapy but developed liver and lung metastases 3 months later and died within 1 month.
  • All of the metastases demonstrated a basaloid histologic variant of adenoid cystic carcinoma that is known for its aggressive potential.
  • Salivary gland carcinoma rarely metastasizes to the choroid; however, evaluation of patients with this carcinoma should include ophthalmic examination.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Choroid Neoplasms / secondary. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Biopsy. Fatal Outcome. Female. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Middle Aged

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  • (PMID = 18254353.001).
  • [ISSN] 1542-8877
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Fatimi SH, Sajwani RA, Rizvi N, Javed MA, Khan A, Ahmad U: Chamberlain mediastinotomy for diagnosis of adenoid cystic carcinoma of trachea. Heart Lung Circ; 2008 Dec;17(6):515-6
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  • [Title] Chamberlain mediastinotomy for diagnosis of adenoid cystic carcinoma of trachea.
  • Primary tracheal tumours are extremely rare.
  • The lesion was biopsied through a chamberlain mediastinotomy, under local and mask anaesthesia and was found to be primary adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / complications. Mediastinoscopy / methods. Tracheal Neoplasms / complications. Tracheal Stenosis / etiology

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  • (PMID = 17931975.001).
  • [ISSN] 1444-2892
  • [Journal-full-title] Heart, lung & circulation
  • [ISO-abbreviation] Heart Lung Circ
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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31. Hashitani S, Urade M, Zushi Y, Segawa E, Okui S, Sakurai K: Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastasis to the lymph node and lung. Oncol Rep; 2007 Jan;17(1):67-72
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  • [Title] Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastasis to the lymph node and lung.
  • Adenoid cystic carcinoma (ACC) is a generally slow-growing but highly malignant salivary gland neoplasm with remarkable capacities for local invasion and lung metastasis.
  • This tumor developed spontaneous metastasis to the neck at the second passage level, and the histological feature changed from ACC to undifferentiated carcinoma (ACCIM).
  • ACCIM caused spontaneous metastasis to the lung at high incidence when transplanted subcutaneously in nude mice.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Disease Models, Animal. Lung Neoplasms / secondary. Mouth Neoplasms / pathology

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  • (PMID = 17143480.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Actins; 0 / Proliferating Cell Nuclear Antigen
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32. Mao N, Zuo C, Gan N, Zhu J, Huang D, Liu D, Xie T, Pan H, Huang Y: [Trachea-bronchoplasty in the treatment of centrally located lung cancer]. Zhongguo Fei Ai Za Zhi; 2005 Aug 20;8(4):329-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Trachea-bronchoplasty in the treatment of centrally located lung cancer].
  • BACKGROUND: To maximize the preservation of functional pulmonary parenchyma and improve the quality of life of patients with centrally located lung cancer, trachea-bronchoplasty has been used in clinical application with good efficacy.
  • The aim of this study is to explore the appropriate admission and management of trachea-bronchoplasty and prevent complications of trachea-bronchial sleeve resection in the treatment of centrally located lung cancer.
  • METHODS: Seventy-six patients with central lung cancer, who were treated with trachea-bronchoplasty from June, 1988 to October, 2004, were analyzed.
  • There were 49 cases of squamous cell carcinoma, 16 adenocarcinoma, 7 adenosquamous carcinoma, 3 small cell lung cancer and 1 adenoid cystic adenocarcinoma.
  • CONCLUSIONS: The trachea-bronchoplasty can not only preserve functional pulmonary parenchyma as much as possible and improve the quality of life of patients, but also provide an operative opportunity to those patients with poor pulmonary function in the treatment of centrally located lung cancer.

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  • (PMID = 21108894.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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33. Mu JW, Li J, Cheng GY, Sun KL, Zhang DC, Wang LJ, Zhang RG, He J: [Surgical treatment of bilateral thoracotomy in patients with lesions of left main bronchus invading carina]. Zhonghua Yi Xue Za Zhi; 2010 Jan 19;90(3):205-7
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  • Of these 4 patients, three patients received left pneumonectomy and one patient received carinal resection without concomitant pulmonary resection.
  • And other three patients were of 1 squamous cell carcinoma and 2 adenoid cystic carcinomas.
  • [MeSH-major] Bronchi / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery. Thoracotomy / methods

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  • (PMID = 20356559.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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34. Minamiya Y, Saito H, Ogawa J: [Experience of twenty-one cases of tracheo-bronchoplasty]. Kyobu Geka; 2008 Oct;61(11):920-6
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  • There are 14 cases of squamous cell carcinoma, 3 cases of adenocarcinoma, 2 cases of adenoid cystic carcinoma, 1 case of inflammatory tracheal stenosis, and 1 case of inflammatory bronchial stenosis.
  • Of 3 cases, we added sleeve resection of pulmonary artery.
  • [MeSH-major] Adenocarcinoma / surgery. Bronchi / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery. Pneumonectomy / methods. Reconstructive Surgical Procedures / methods. Trachea / surgery. Tracheal Stenosis / surgery

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  • (PMID = 18939426.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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35. de Perrot M, Fadel E, Mercier O, Mussot S, Chapelier A, Dartevelle P: Long-term results after carinal resection for carcinoma: does the benefit warrant the risk? J Thorac Cardiovasc Surg; 2006 Jan;131(1):81-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term results after carinal resection for carcinoma: does the benefit warrant the risk?
  • OBJECTIVE: We sought to determine whether the benefit warrants the risk in patients undergoing carinal resection for carcinoma.
  • RESULTS: Between June 1981 and August 2004, 119 patients underwent carinal resection for carcinoma in our institution.
  • Carinal pneumonectomy was performed in 103 cases (96 right and 7 left pneumonectomies), carinal resection plus right upper lobectomy in 3, carinal resection after left pneumonectomy in 2, and carinal resection without pulmonary resection in 11.
  • Superior vena caval resection was combined with carinal pneumonectomy in 25 patients with bronchogenic carcinoma (13 patients had complete superior vena caval resection with graft interposition).
  • The 5- and 10-year survivals were 44% and 25%, respectively, for patients with bronchogenic carcinoma (n = 100).
  • The 5- and 10-year survivals in the remaining 19 patients reached 66% and 48%, respectively, and were best in patients with neuroendocrine carcinoma (100% survival at 10 years) and adenoid cystic carcinoma (69% survival at 10 years).
  • CONCLUSIONS: Surgical intervention for carcinoma involving the carina is feasible, with acceptable mortality and good long-term survival in selected patients.
  • The presence of positive N2 disease should, however, be considered a potential contraindication to carinal resection in patients with bronchogenic carcinoma because of the poor long-term survival.
  • [MeSH-major] Lung Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Pneumonectomy / methods. Trachea / surgery. Tracheal Neoplasms / surgery

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  • (PMID = 16399298.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Dahse R, Kosmehl H: Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma. Br J Cancer; 2008 Jul 8;99(1):90-2
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  • [Title] Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma.
  • Activating mutations within the epidermal growth factor receptor (EGFR) identify lung adenocarcinoma patients with improved clinical responses to tyrosine kinase inhibitors gefitinib and erlotinib.
  • By screening salivary gland carcinoma, two drug-sensitizing EGFR exon 19 delE746-A750 mutations were identified in an adenocystic and in a mucoepidermoid carcinoma of the parotid gland.
  • [MeSH-minor] Aged. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Mucoepidermoid / drug therapy. Carcinoma, Mucoepidermoid / genetics. DNA, Neoplasm / genetics. Erlotinib Hydrochloride. Exons. Female. Humans. Male. Middle Aged. Mutation. Quinazolines / therapeutic use

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  • (PMID = 18542074.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib
  • [Other-IDs] NLM/ PMC2453031
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37. Banki F, Khalil K, Kott MM, Cota AL: Adenoid cystic carcinoma of the thymus gland: a rare tumor. Ann Thorac Surg; 2010 Oct;90(4):e56-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the thymus gland: a rare tumor.
  • We present a case of adenoid cystic carcinoma of thymus in a 65-year-old woman that was initially misdiagnosed and was treated as non-small cell carcinoma of the lung.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Thymus Neoplasms / diagnosis

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  • [Copyright] Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20868782.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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38. Bell D, Roberts D, Kies M, Rao P, Weber RS, El-Naggar AK: Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications. Cancer; 2010 Dec 15;116(24):5749-56
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  • [Title] Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications.
  • BACKGROUND: Adenoid cystic carcinoma (ACC), a rare and progressive salivary malignancy, is characterized by cellular, morphologic, and clinical heterogeneity.

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  • [Copyright] Copyright © 2010 American Cancer Society.
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  • (PMID = 20824717.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NIDCR NIH HHS / DE / U01 DE019765; United States / NIDCR NIH HHS / DE / U01DE019756; United States / NCI NIH HHS / CA / CA16672; United States / NIDCR NIH HHS / DE / U01 DE019765-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ NIHMS219730; NLM/ PMC2998592
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39. Iczkowski KA, Montironi R: Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu. J Clin Pathol; 2006 Dec;59(12):1327-30
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  • [Title] Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu.
  • Adenoid cystic/basal cell carcinoma (ACBCC) is a rare neoplasm in the prostate.
  • The HER-2/neu (c-erbB-2) gene has been reportedly overexpressed in adenoid cystic carcinomas in other organs, but its status in prostatic ACBCC was uncertain.
  • One patient had metastasis to the lung.
  • Protein and mRNA expression were 2+ to 3+ (of 3+) in all patients with ACBCC, compared to a breast cancer control with strong reactivity, whereas protein expression was noted in only one acinar carcinoma and mRNA expression was absent in all acinar carcinomas.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Basal Cell / metabolism. Mixed Tumor, Malignant / metabolism. Prostatic Neoplasms / metabolism. Receptor, ErbB-2 / metabolism


40. Yang Y, Jiang M, Cao D, Gou H: [Clinical analysis of 8 cases of tracheal adenoid cystic carcinoma]. Zhongguo Fei Ai Za Zhi; 2007 Jun 20;10(3):237-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of 8 cases of tracheal adenoid cystic carcinoma].
  • BACKGROUND: Tracheal adenoid cystic carcinoma (TACC) is a rare, low malignant and primary tracheal carcinoma, which is easily misdiagnosed and missedly diagnosed.
  • Fiberoptic bronchoscope and computerized tomography were reliable examinations for final diagnosis.

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  • (PMID = 21118655.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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41. Okada T, Kamada T, Tsuji H, Mizoe JE, Baba M, Kato S, Yamada S, Sugahara S, Yasuda S, Yamamoto N, Imai R, Hasegawa A, Imada H, Kiyohara H, Jingu K, Shinoto M, Tsujii H: Carbon ion radiotherapy: clinical experiences at National Institute of Radiological Science (NIRS). J Radiat Res; 2010;51(4):355-64
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  • Tumors that appear to respond favorably to carbon ions include locally advanced tumors as well as histologically non-squamous cell tumor types such as adenocarcinoma, adenoid cystic carcinoma, malignant melanoma, hepatoma, and bone/soft tissue sarcoma.
  • [MeSH-minor] Academies and Institutes. Carcinoma, Hepatocellular / radiotherapy. Carcinoma, Non-Small-Cell Lung / radiotherapy. Esophageal Neoplasms / radiotherapy. Female. Humans. Japan. Liver Neoplasms / radiotherapy. Lung Neoplasms / radiotherapy. Male. Pancreatic Neoplasms / radiotherapy. Prostatic Neoplasms / radiotherapy. Rectal Neoplasms / radiotherapy. Uterine Neoplasms / radiotherapy

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  • (PMID = 20508375.001).
  • [ISSN] 1349-9157
  • [Journal-full-title] Journal of radiation research
  • [ISO-abbreviation] J. Radiat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 7440-44-0 / Carbon
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42. Singh A, Ramesh V: Primary cutaneous adenoid cystic carcinoma with distant metastasis: a case report and brief literature review. Indian J Dermatol Venereol Leprol; 2010 Mar-Apr;76(2):176-9
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  • [Title] Primary cutaneous adenoid cystic carcinoma with distant metastasis: a case report and brief literature review.
  • Primary adenoid cystic carcinoma (PCACC) of skin is a rare tumor, and those who show distant metastasis are even rarer.
  • We report a case of PCACC on the face of a 55-year-old man who showed bilateral lung metastasis and on palliative chemotherapy showed significant regression of the primary tumor.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 20228549.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 11
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43. Wang X, Lu W, Zhu C, Ye F, Xie X: Adenoid cystic carcinoma of Bartholin's gland with lung metastasis: a case report. Eur J Gynaecol Oncol; 2009;30(3):317-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of Bartholin's gland with lung metastasis: a case report.
  • BACKGROUND: Adenoid cystic carcinoma (ACC) of the Bartholin's gland is very rare.
  • CASE: In the present study we report the case of a 41-year-old Chinese woman who suffered from ACC of the Bartholin's gland with lung metastases and repeated local recurrence, and discuss the most suitable treatment for late stage ACC of the Bartholin's gland.
  • [MeSH-major] Bartholin's Glands. Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Neoplasm Recurrence, Local. Vaginal Neoplasms / pathology

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  • (PMID = 19697630.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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44. Hu K, Li SL, Gan YH, Wang CY, Yu GY: Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt. Oral Oncol; 2009 Feb;45(2):156-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt.
  • Hematogenous metastasis is one of the most important factors determining the outcome of the patients with salivary adenoid cystic carcinoma (SACC).
  • A transcriptomic microarray analysis between the lower lung-metastatic rate cell line SACC-83 and the higher lung-metastatic rate cell line SACC-LM were performed, and eight genes, showed by microarray to be highly expressed in SACC-LM, were picked for validation by quantitative real-time PCR.
  • Conclusively, the results suggest that epiregulin may play an important role in lung metastasis of SACC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Cell Movement / drug effects. Epidermal Growth Factor / pharmacology. Lung Neoplasms / secondary. Salivary Gland Neoplasms / pathology


45. Younes MN, Park YW, Yazici YD, Gu M, Santillan AA, Nong X, Kim S, Jasser SA, El-Naggar AK, Myers JN: Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. Mol Cancer Ther; 2006 Nov;5(11):2696-705
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  • [Title] Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model.
  • We hypothesized that epidermal growth factor (EGF) receptor (EGFR) activation and vascular endothelial growth factor (VEGF)-induced angiogenic signals are important for the progression and metastasis of human salivary adenoid cystic carcinoma (ACC).
  • AEE788 inhibited tumor growth and prevented lung metastasis in nude mice.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Purines / therapeutic use. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Salivary Gland Neoplasms / drug therapy. Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors


46. Locati LD, Guzzo M, Bossi P, Massone PP, Conti B, Fumagalli E, Bareggi C, Cantù G, Licitra L: Lung metastasectomy in adenoid cystic carcinoma (ACC) of salivary gland. Oral Oncol; 2005 Oct;41(9):890-4
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  • [Title] Lung metastasectomy in adenoid cystic carcinoma (ACC) of salivary gland.
  • To define the role of surgical management of lung metastases in ACC.
  • Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed.
  • Lung metastasectomy provided a prolonged FFP in a high selected subset of patients with ACC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Lung / surgery. Lung Neoplasms / surgery. Salivary Gland Neoplasms


47. Chen F, Sonobe M, Sato K, Fujinaga T, Shoji T, Sakai H, Miyahara R, Bando T, Okubo K, Hirata T, Date H: Pulmonary resection for metastatic head and neck cancer. World J Surg; 2008 Aug;32(8):1657-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pulmonary resection for metastatic head and neck cancer.
  • BACKGROUND: Pulmonary metastasectomy has become the standard therapy for various metastatic malignancies to the lungs; however, little data have been available about lung metastasectomy for head and neck cancers.
  • To confirm a role for resection of pulmonary metastases for such tumors, we reviewed our institutional experience.
  • METHODS: Between 1991 and 2007, 20 patients with pulmonary metastases from head and neck cancers underwent complete pulmonary resection.
  • All patients had obtained or had obtainable locoregional control of their primary head and neck cancers.
  • RESULTS: Of the 20 patients, 10 (50%) had squamous cell carcinoma, 7 (35%) had adenoid cystic carcinoma, and 3 had miscellaneous carcinomas.
  • The median disease-free interval from the time of treatment of the head and neck primary cancers to the development of pulmonary metastases was 27 months.
  • Disease-free survival rate was 25.0% at 5 years after pulmonary resection.
  • Patients with squamous cell carcinoma and male sex showed a worse overall survival (p = 0.04 and 0.03, respectively).
  • CONCLUSION: The current practice of pulmonary metastasectomy for head and neck cancers in our institution was well justified.
  • A disease-free interval equal to or longer than 12 months, nonsquamous cell carcinoma, and female sex might be relevant to a better prognosis.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Head and Neck Neoplasms / pathology. Lung Neoplasms / secondary. Lung Neoplasms / surgery

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  • (PMID = 18553194.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Axelsson R, Herlin G, Bååth M, Aspelin P, Kölbeck KG: Role of scintigraphy with technetium-99m depreotide in the diagnosis and management of patients with suspected lung cancer. Acta Radiol; 2008 Apr;49(3):295-302
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  • [Title] Role of scintigraphy with technetium-99m depreotide in the diagnosis and management of patients with suspected lung cancer.
  • BACKGROUND: In Sweden, there are over 3000 new lung cancer cases every year.
  • PURPOSE: To evaluate the diagnostic value of the somatostatin analogue depreotide in patients with suspected lung cancer, and to determine in which clinical settings it would be beneficial to use 99mTc-depreotide scintigraphy.
  • MATERIAL AND METHODS: We included 99 consecutive patients referred to our hospital with suspected lung cancer.
  • RESULTS: 99mTc-depreotide uptake was found in 62 out of 66 malignancies, including 57 of 58 primary lung cancer cases.
  • Two cases of lung metastasis (one from a colon cancer and one from an adenoid cystic carcinoma originating in the palate) and one rib chondrosarcoma did not show depreotide uptake.
  • The sensitivity in detecting malignancy was 94%, and in detecting lung cancer 98%.
  • CONCLUSION: 99mTc-depreotide scintigraphy has a high sensitivity in detecting lung cancer.
  • [MeSH-major] Hamartoma / diagnosis. Lung / radionuclide imaging. Lung Neoplasms / diagnosis. Organotechnetium Compounds. Radiopharmaceuticals. Somatostatin / analogs & derivatives
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. False Negative Reactions. False Positive Reactions. Female. Humans. Image Enhancement / methods. Male. Middle Aged. Observer Variation. Pneumonia / diagnosis. Predictive Value of Tests. Reproducibility of Results. Sensitivity and Specificity. Tomography, X-Ray Computed / methods

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  • (PMID = 18365818.001).
  • [ISSN] 1600-0455
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 51110-01-1 / Somatostatin; 9M48M2SF02 / technetium Tc 99m depreotide
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49. Sano Y, Kanazawa S, Mimura H, Gobara H, Hiraki T, Fujiwara H, Yamane M, Toyooka S, Oto T, Date H: A novel strategy for treatment of metastatic pulmonary tumors: radiofrequency ablation in conjunction with surgery. J Thorac Oncol; 2008 Mar;3(3):283-8
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  • [Title] A novel strategy for treatment of metastatic pulmonary tumors: radiofrequency ablation in conjunction with surgery.
  • INTRODUCTION: Local treatment that includes surgical resection of metastatic pulmonary tumors is controversial because of the biologic features and invasiveness of these tumors.
  • We report our experience with a premeditated treatment involving combined computed tomography-guided radiofrequency ablation and surgical resection in three patients with metastatic pulmonary tumors.
  • The first was a 67-year-old man with pulmonary metastases of bronchial adenoid cystic carcinoma.
  • We performed partial resection of five tumors in the right lung and ablated a tumor in the left lung.
  • The second was a 66-year-old man with pulmonary metastases of renal cell carcinoma.
  • The third was a 55-year-old man with pulmonary metastases of high-grade sarcoma of the right thigh.
  • We performed partial resection of five tumors in the left lung and ablated a tumor in the right lung.
  • RESULTS: Two patients had metastatic lesions on both sides of the lung; we performed surgical resection on one side and radiofrequency ablation contralaterally to avoid bilateral thoracotomy.
  • CONCLUSIONS: Premeditated treatment involving a combination of radiofrequency ablation and surgical resection can be a useful option in patients with metastatic pulmonary tumors, improving curability and avoiding highly invasive procedures.
  • [MeSH-major] Bronchial Neoplasms / pathology. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Renal Cell / surgery. Catheter Ablation / methods. Kidney Neoplasms / pathology. Lung Neoplasms / surgery. Pneumonectomy / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 18317072.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Molina JR, Aubry MC, Lewis JE, Wampfler JA, Williams BA, Midthun DE, Yang P, Cassivi SD: Primary salivary gland-type lung cancer: spectrum of clinical presentation, histopathologic and prognostic factors. Cancer; 2007 Nov 15;110(10):2253-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary salivary gland-type lung cancer: spectrum of clinical presentation, histopathologic and prognostic factors.
  • BACKGROUND: Primary salivary-type lung cancers are rare tumors that include adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC).
  • METHODS: In this study, the authors analyzed clinical outcome data from 62 patients who presented with a diagnosis of primary salivary-type lung cancer at the Mayo Clinic (Rochester, Minn) from 1972 to 2002.
  • RESULTS: The median age at diagnosis for patients with MEC was 40 years (range, 6-78 years); and, for patients ACC, the median age at diagnosis was 54 years (range, 21-76 years).
  • Most salivary-type lung cancers presented in the trachea, in the carina, or in a main stem bronchus (70.7%).
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Lung Neoplasms / pathology. Salivary Glands / pathology

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17918258.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Su T, Sun HC, Zang GX, Zhang H, Lu DM: [Inhibition of proliferation of salivary adenoid cystic carcinoma by targeting gene transfer]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2007 Mar;42(3):184-5
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  • [Title] [Inhibition of proliferation of salivary adenoid cystic carcinoma by targeting gene transfer].
  • RESULTS: Expression of extrinsic TRAIL gene driven by hTERT promoter was detected in SACC-83 cells, and not detected in human embryonic lung fibroblast (HEL) cells.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology. TNF-Related Apoptosis-Inducing Ligand / genetics. Telomerase / genetics

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  • (PMID = 17565833.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / TNF-Related Apoptosis-Inducing Ligand; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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52. Lin WY, Hsu WH: Tumor-to-tumor metastasis: maxillary sinus adenoid cystic carcinoma metastasizing to double primary lung adenocarcinoma. Ann Thorac Surg; 2010 Oct;90(4):e59-61
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  • [Title] Tumor-to-tumor metastasis: maxillary sinus adenoid cystic carcinoma metastasizing to double primary lung adenocarcinoma.
  • The most frequent metastatic donor is lung cancer, and the most frequent recipient is renal cell carcinoma.
  • Here we present a patient in whom lung cancer served as a metastatic recipient and maxillary sinus adenoid cystic carcinoma acted as a metastatic donor.
  • This patient has double primary lung cancer, which increased the complexity of this case.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology

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  • [Copyright] Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20868783.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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53. Hou JL, Wu LY, Zhang HT, Li N, Yu GZ: [Clinicopathological characteristics of six patients with adenoid cystic carcinoma of the Bartholin gland]. Zhonghua Zhong Liu Za Zhi; 2010 Apr;32(4):290-3
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  • [Title] [Clinicopathological characteristics of six patients with adenoid cystic carcinoma of the Bartholin gland].
  • OBJECTIVE: To evaluate the clinicopathological characteristics and treatment of adenoid cystic carcinoma of the Bartholin gland.
  • METHODS: The clinicopathological data of six patients with adenoid cystic carcinoma of the Bartholin gland were retrospectively analyzed.
  • Surgery was the primary treatment.
  • RESULTS: All patients had definite pathological diagnosis.
  • Recurrence developed in 4 cases including 3 with both local recurrence and lung metastasis, and one had lung metastasis only.
  • One patient died of lung metastasis and her total survival period was 135 months.
  • CONCLUSION: Adenoid cystic carcinoma of the Bartholin gland is a slow growing but locally very aggressive neoplasm with a high capacity for local recurrence and lung metastasis.
  • [MeSH-major] Bartholin's Glands / pathology. Carcinoma, Adenoid Cystic / surgery. Vulva / surgery. Vulvar Neoplasms / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Lymph Node Excision. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Radiotherapy, High-Energy. Retrospective Studies. Survival Rate

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  • (PMID = 20510082.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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54. Lin TT, He YJ, Zhang H, Song GX, Tang DR, Zhao HF: [Analysis of treatment and prognosis of orbital adenoid cystic carcinoma]. Zhonghua Yan Ke Za Zhi; 2009 Apr;45(4):309-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of treatment and prognosis of orbital adenoid cystic carcinoma].
  • OBJECTIVE: To summarize the treatment outcomes of orbital adenoid cystic carcinoma and to evaluate prognostic factors.
  • METHOD: A retrospective case series study was performed on 75 patients with orbital adenoid cystic carcinoma treated from 1991 to 2006.
  • RESULTS: The 2- and 5-year local recurrence rate of solid type orbital adenoid cystic carcinoma was significantly higher than that of the adeno-tubiform type [2-year, 85% (17/20) vs 23.53% (8/34), chi(2) = 19.14, P = 0.000; 5-year, 100% (19/19) vs 64.52% (20/31), Fisher's exact test, P = 0.003].
  • They may spread to the lung, bone, liver and lymph node.
  • Both of the lung and bone metastasis rates were 33.33% (3/9).
  • CONCLUSIONS: Orbital adenoid cystic carcinoma is one of the most malignant tumors in the orbit.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Orbital Neoplasms / therapy

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  • (PMID = 19575961.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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55. Davies AM, Ho C, Metzger AS, Beckett LA, Christensen S, Tanaka M, Lara PN, Lau DH, Gandara DR: Phase I study of two different schedules of bortezomib and pemetrexed in advanced solid tumors with emphasis on non-small cell lung cancer. J Thorac Oncol; 2007 Dec;2(12):1112-6
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  • [Title] Phase I study of two different schedules of bortezomib and pemetrexed in advanced solid tumors with emphasis on non-small cell lung cancer.
  • Tumor types included lung (n = 16), adenoid cystic carcinoma (n = 2), prostate (n = 2), sarcoma (n = 2), breast (n = 1), thymus (n = 1), head and neck (n = 1), and gastrointestinal(n = 2).
  • Of the 16 patients with non-small cell lung cancer, 2 (12.5%) had partial response and 9 had stable disease, for a disease control rate of 68.8%.
  • Based on the observed efficacy, a phase II study in non-small cell lung cancer is warranted.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Non-Small-Cell Lung / drug therapy. Carcinoma, Non-Small-Cell Lung / mortality. Lung Neoplasms / drug therapy. Lung Neoplasms / mortality

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  • (PMID = 18090584.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Boronic Acids; 0 / Glutamates; 0 / Pyrazines; 04Q9AIZ7NO / Pemetrexed; 5Z93L87A1R / Guanine; 69G8BD63PP / Bortezomib
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56. Roviaro G, Vergani C, Maciocco M, Varoli F, Francese M, Despini L: Tracheal sleeve pneumonectomy: long-term outcome. Lung Cancer; 2006 Apr;52(1):105-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Selected primary lung cancers less than 2cm from the carina or invading the tracheo-bronchial angle, formerly considered inoperable, can be amenable to tracheal sleeve pneumonectomy (TSP).
  • Since 1993 in every patient with lung cancer we perform a thoracoscopic exploration as the first step of the intervention.
  • TSP is the only concrete option for treating lung cancer originating less than 2 cm from the carina.
  • [MeSH-major] Lung Neoplasms / surgery. Pneumonectomy. Tracheal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Large Cell / surgery. Carcinoma, Squamous Cell / surgery. Humans. Pleural Neoplasms / secondary. Pleural Neoplasms / surgery. Prognosis. Survival Rate. Thoracotomy. Trachea

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  • (PMID = 16481067.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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57. Zang G, Miao L, Mu Y, Qiao C, Liu J, Ke X, Zheng C, Sun H: Adenoviral mediated transduction of adenoid cystic carcinoma by human TRAIL gene driven with hTERT tumor specific promoter induces apoptosis. Cancer Biol Ther; 2009 May;8(10):966-72
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  • [Title] Adenoviral mediated transduction of adenoid cystic carcinoma by human TRAIL gene driven with hTERT tumor specific promoter induces apoptosis.
  • Adenoid cystic carcinoma (ACC) is a common malignant tumor in salivary glands.
  • Transduction of SACC-83, but not of control human embryo-fibrocyte lung (HEL) cells, led to apoptosis as measured by MTT assay and flow cytomerty.
  • [MeSH-major] Apoptosis / genetics. Carcinoma, Adenoid Cystic / therapy. Salivary Gland Neoplasms / therapy. TNF-Related Apoptosis-Inducing Ligand / genetics. Telomerase / genetics

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  • (PMID = 19587531.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Formazans; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / Tetrazolium Salts; 23305-68-2 / MTT formazan; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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58. Li L, Luo W, Gan X, Su L, Zeng W: [Adenoid cystic carcinoma of ENT associated with hard lump: a report of 9 cases]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Oct;20(19):875-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma of ENT associated with hard lump: a report of 9 cases].
  • OBJECTIVE: To assess the clinical and pathological features of the patients with ENT adenoid cystic carcinoma (ENTACC) who presented with hard lump, and to detect its prognosis.
  • RESULT: The period from the occurrence of primary symptoms to definite diagnosis was 4 years and 3 months on average.
  • Five patients died, among which 3 died with lung metastases, 2 with local lymphatic metastases, 1 with bone metastases and 1 with encephalic diffusion.
  • CONCLUSION: The pathological result of these 9 cases were all salivary gland derived adenoid cystic carcinoma of solid type.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Salivary Gland Neoplasms

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  • (PMID = 17168112.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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59. Pedro Silva IE, Osorio Acosta V, Farfán Chávez FA: [Cystic adenoid carcinoma of the prostate. Report of two cases]. Arch Esp Urol; 2006 Oct;59(8):823-5
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  • [Title] [Cystic adenoid carcinoma of the prostate. Report of two cases].
  • [Transliterated title] Carcinoma adenoideo quístico de la próstata. Presentación de 2 casos.
  • OBJECTIVE: We report two cases with the pathologic diagnosis of cystic adenoid carcinoma of the prostate, an extremely rare tumor.
  • METHODS: We evaluate two patients with different age, clinical presentation, diagnosis, treatment and outcome.
  • The first patient underwent radical prostatectomy and adjuvant immunotherapy; six years after surgery he developed lung metastasis and died.
  • CONCLUSIONS: The clinical presentation is non specific, with the diagnosis generally obtained by transurethral resection or transrectal biopsy after the suspicion of an abnormal digital rectal examination or ultrasound.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Prostatic Neoplasms / diagnosis


60. Syed IM, Howard DJ: Should we treat lung metastases from adenoid cystic carcinoma of the head and neck in asymptomatic patients? Ear Nose Throat J; 2009 Jun;88(6):969-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Should we treat lung metastases from adenoid cystic carcinoma of the head and neck in asymptomatic patients?
  • Adenoid cystic carcinoma is a rare malignant tumor that is well known for its deceptively encouraging 5-year survival rate and its dismal survival rate at longer intervals.
  • When a metastasis is limited to the lung in an asymptomatic patient with no locoregional recurrence, metastasectomy might provide some long-term benefit, although we cannot know for certain.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Head and Neck Neoplasms / pathology. Lung Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Female. Humans. Prognosis. Thoracotomy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19517404.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Hu K, Gan YH, Li SL, Gao Y, Wu DC, Wang CY, Yu GY: Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma. Oncol Rep; 2009 Jan;21(1):137-43
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  • [Title] Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma.
  • Lung metastasis is one of the important characteristics of salivary adenoid cystic carcinoma (SACC).
  • Although activation of extracellular signal-regulated kinase 1/2 (ERK1/2) pathway may be associated with cancer progression in some malignant tumors, its roles in lung metastasis of SACC remains unclear.
  • We examined the expression of activated ERK1/2 in SACC-LM with high lung-metastatic rate and SACC-83 with low lung-metastatic rate, as well as in the tissues from lung-metastatic and non-metastatic groups of SACC patients.
  • Similarly, immunohistochemistry showed that expression of activated ERK1/2 was detected in 73% (8/11) of the primary tissues from SACC patients with lung metastasis, while only 25% (3/12) of the primary tissues from SACC patients without lung metastasis (P<0.05).
  • The present findings suggested that the elevated expression of activated ERK1/2 may play a role in lung metastasis of salivary adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lung Neoplasms / secondary. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / metabolism. Salivary Gland Neoplasms / pathology

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  • (PMID = 19082454.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3
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62. Florentine BD, Fink T, Avidan S, Braslavsky D, Raza A, Cobb CJ: Extra-salivary gland presentations of adenoid cystic carcinoma: a report of three cases. Diagn Cytopathol; 2006 Jul;34(7):491-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-salivary gland presentations of adenoid cystic carcinoma: a report of three cases.
  • Adenoid cystic carcinoma (ACC) is a malignant neoplasm most commonly originating in salivary glands of the head and neck area.
  • When ACC presents outside of these locations, the diagnosis may become more challenging.
  • Two cases were metastatic; in case 1 the initial presentation was widespread bony metastasis of unknown primary origin.
  • The other metastatic case (case 2) was from a patient presenting with a pleural effusion and a history of previously treated metastatic pulmonary ACC.
  • Case 3 was a primary bronchial ACC.
  • In conclusion, ACC can present in various body sites and cytologists must consider this neoplasm when presented with a basaloid carcinoma of uncertain origin.
  • [MeSH-major] Bone Neoplasms / secondary. Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Pleural Effusion / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Fine-Needle. Female. Humans. Middle Aged. Neoplasms, Unknown Primary

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16783770.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Triantafillidou K, Dimitrakopoulos J, Iordanidis F, Koufogiannis D: Management of adenoid cystic carcinoma of minor salivary glands. J Oral Maxillofac Surg; 2006 Jul;64(7):1114-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of adenoid cystic carcinoma of minor salivary glands.
  • PURPOSE: Adenoid cystic carcinoma (ACC) is a rare malignant tumor originating from the salivary glands.
  • The distribution of the primary sites was buccal mucosa (3), floor of the mouth (1), hard palate (3), soft palate (2), junction of hard and soft palate (7), and hard or soft palate with spread in the paranasal sinus etc (6).
  • Distant metastases (lung) occurred in 2 patients, 2 years and 6 years after completing the treatment.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / surgery. Ki-67 Antigen / metabolism. Salivary Gland Neoplasms / surgery

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  • (PMID = 16781345.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
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64. Xu Q, Liu X, Cai Y, Yu Y, Chen W: RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells. Tumour Biol; 2010 Jun;31(3):217-24
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  • [Title] RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells.
  • Here, we show that ADAM9 is highly expressed in metastatic cancer tissues and in an adenoid cystic carcinoma cell line with a high metastatic potential.
  • Using RNA interference for gene silencing, we show that ADAM9 is essential for in vitro cancer cell proliferation and invasion as well as in vivo cancer metastasis in an experimental murine model of lung metastases.
  • These data indicate that ADAM9 is potentially an important new therapeutic target for the prevention of tumor metastases in adenoid cystic carcinoma.
  • [MeSH-major] ADAM Proteins / antagonists & inhibitors. Carcinoma, Adenoid Cystic / therapy. Membrane Proteins / antagonists & inhibitors. RNA Interference

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  • (PMID = 20422344.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 3.4.24.- / ADAM Proteins; EC 3.4.24.- / ADAM9 protein, human
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65. Fu ZC, Zhang B, Fu ZJ: As2O3 may be a treatment option for adenoid cystic carcinoma of salivary gland. Med Hypotheses; 2010 Dec;75(6):490-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] As2O3 may be a treatment option for adenoid cystic carcinoma of salivary gland.
  • Adenoid cystic carcinoma (ACC) is an uncommon tumor of the head and neck that may occur in any salivary gland tissue.
  • It is a high malignant carcinoma characterized by intensive local invasion and insidious distant metastasis to the lung at an early stage, which is responsible for a poor long-term survival rate.
  • The main clinical treatment to adenoid cystic carcinoma depended on surgical operation in the past.
  • However, it was not so easy to completely excise adenoid cystic carcinoma which resulting in the residual of tumor cells.
  • Adenoid cystic carcinoma is not sensitive to conventional chemotherapeutics, so it is necessary to explore a new kind of drug which possesses inhibition and killing effects to this tumor.
  • A(S2)O(3) may become a treatment option for adenoid cystic carcinoma of salivary gland.
  • [MeSH-major] Apoptosis / drug effects. Arsenicals / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Growth Inhibitors / therapeutic use. Oxides / therapeutic use. Salivary Gland Neoplasms / drug therapy

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20656411.001).
  • [ISSN] 1532-2777
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arsenicals; 0 / Growth Inhibitors; 0 / Oxides; S7V92P67HO / arsenic trioxide
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66. Park YW, Kim SG, Choi JY, Lee SK: Recapitulating orthotopic tumor model through establishment of a parotid gland tumor with lung metastasis using HeLa cell injection into nude mice. Oncol Rep; 2010 Mar;23(3):701-8
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  • [Title] Recapitulating orthotopic tumor model through establishment of a parotid gland tumor with lung metastasis using HeLa cell injection into nude mice.
  • HeLa cells showed significantly higher lung metastatic potential in the parotid gland than in the subcutis.
  • [MeSH-major] Lung Neoplasms / secondary. Parotid Neoplasms / pathology
  • [MeSH-minor] Animals. Carcinoma, Adenoid Cystic / blood supply. Carcinoma, Adenoid Cystic / pathology. Epidermal Growth Factor / pharmacology. Fibroblast Growth Factor 2 / analysis. HeLa Cells. Humans. Male. Mice. Mice, Nude. Neoplasm Transplantation. Receptor, Epidermal Growth Factor / metabolism. Transplantation, Heterologous. Xenograft Model Antitumor Assays

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  • (PMID = 20127009.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 103107-01-3 / Fibroblast Growth Factor 2; 62229-50-9 / Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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67. Chu WF, Wu DM, Liu W, Wu LJ, Li DZ, Xu DY, Wang XF: Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma. Oral Oncol; 2009 Nov;45(11):998-1004
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  • [Title] Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma.
  • New chemotherapeutic strategy should be investigated to enhance clinical management in salivary gland adenoid cystic carcinoma (ACC).
  • Cell survives, apoptosis, cell cycle progression and molecular targets were identified by multiple detecting techniques, including trypan blue dye exclusion assay, electron microscopy, AO/EB staining, flow cytometry and immunoblotting in human lung high metastasis cell line of salivary gland adenoid cystic carcinoma (ACC-M).
  • [MeSH-major] Anticarcinogenic Agents / pharmacology. Carcinoma, Adenoid Cystic / drug therapy. Lung Neoplasms / drug therapy. Salivary Gland Neoplasms / drug therapy. Thiocyanates / pharmacology


68. Miettinen M, Lasota J: KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol; 2005 Sep;13(3):205-20

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  • Also, KIT is expressed in pulmonary and other small cell carcinomas, adenoid cystic carcinoma, renal chromophobe carcinoma, thymic, and some ovarian and few breast carcinomas.
  • KIT tyrosine kinase inhibitors such as imatinib mesylate are the generally accepted treatment of metastatic GISTs, and their availability has prompted an active search for other treatment targets among KIT-positive tumors such as myeloid leukemias and small cell carcinoma of the lung, with variable and often nonconvincing results.

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  • (PMID = 16082245.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 239
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69. Yen YT, Lai WW: Right thoracotomy for carinal resection with left thoracoscopic pneumonectomy as a new approach for left sleeve pneumonectomy: a case report. Kaohsiung J Med Sci; 2010 Nov;26(11):609-14

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  • A biopsy proved the tumor to be adenoid cystic carcinoma.
  • The distance between the tumor-free left main bronchus and the carina was large; therefore, preservation of the left lung would have compromised the healing of the carinal tracheobronchoplasty and led to life-threatening complications.

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  • [Copyright] Copyright © 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 21126714.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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70. Li Y, Luo JY, Cui HF, Zheng L, Du SS: Study on anti-metastasis of heparin derivatives as ligand antagonist of p-selectin. Biomed Pharmacother; 2010 Dec;64(10):654-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Heparin / analogs & derivatives. Heparin / pharmacology. Lung Neoplasms / prevention & control. Lung Neoplasms / secondary. P-Selectin / antagonists & inhibitors
  • [MeSH-minor] Anticoagulants / adverse effects. Anticoagulants / metabolism. Anticoagulants / pharmacology. Blood Platelets / drug effects. Blood Platelets / metabolism. Carcinoma, Adenoid Cystic / blood. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / pathology. Cell Adhesion / drug effects. Cell Line, Tumor. Cell Proliferation / drug effects. Cells, Cultured. Endothelial Cells / drug effects. Endothelial Cells / metabolism. Humans. Ligands. Neoplasm Metastasis. Salivary Gland Neoplasms / blood. Salivary Gland Neoplasms / drug therapy. Salivary Gland Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20970300.001).
  • [ISSN] 1950-6007
  • [Journal-full-title] Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
  • [ISO-abbreviation] Biomed. Pharmacother.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Ligands; 0 / P-Selectin; 9005-49-6 / Heparin
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71. Aksu K, Aktaş Z, Aksu F, Orsel O, Demirağ F, Sipit T, Firat Güven S: Spindle cell sarcomatoid carcinoma: first case reported in the trachea. Tuberk Toraks; 2009;57(3):337-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spindle cell sarcomatoid carcinoma: first case reported in the trachea.
  • Microscopically, the tumor was composed of fascicular pattern of spindle cells with atypical mitotic figures and nuclear pleomorphism, positively reactive to epithelial membrane antigen supporting a diagnosis of tumour with epithelial differentiation.
  • These findings supported the diagnosis of a spindle cell sarcomatoid carcinoma of trachea.
  • Spindle cell carcinoma cases are reported in many sites, such as head and neck region, larynx, digestive tract, breast, kidney, genital tract, skin and lung, but to our knowledge, not in trachea.
  • Primary malignant tracheal tumours consist mainly of squamous cell carcinoma and adenoid cystic carcinoma and generally have an aggressive course with poor prognosis.
  • We report the first presentation of a spindle cell sarcomatoid carcinoma of trachea together with the clinical course of the patient.
  • [MeSH-major] Carcinoma / pathology. Tracheal Neoplasms / pathology

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  • (PMID = 19787474.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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72. Seethala RR, Hunt JL, Baloch ZW, Livolsi VA, Leon Barnes E: Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol; 2007 Nov;31(11):1683-94
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  • [Title] Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature.
  • High-grade transformation of adenoid cystic carcinoma (ACC) (previously referred to as dedifferentiation) is a rare phenomenon that does not fit into the traditional ACC grading schemes.
  • Distant metastases to the lung (n=2) and soft tissue of the shoulder (n=1) were observed.
  • The most common morphologies for the high-grade component were poorly differentiated cribriform adenocarcinoma and solid undifferentiated carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Papillary / pathology. Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18059225.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin D; 0 / Cyclins; 0 / Ki-67 Antigen; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 53
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73. Pogodzinski MS, Sabri AN, Lewis JE, Olsen KD: Retrospective study and review of polymorphous low-grade adenocarcinoma. Laryngoscope; 2006 Dec;116(12):2145-9
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  • One patient had regional nodal disease 20 years after the initial procedure, and another had lung metastasis.
  • The most common initial diagnoses were polymorphous low-grade adenocarcinoma, adenoid cystic carcinoma, and pleomorphic adenoma.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Salivary Glands, Minor


74. Schwentner I, Obrist P, Thumfart W, Sprinzl G: Distant metastasis of parotid gland tumors. Acta Otolaryngol; 2006 Apr;126(4):340-5
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  • The likelihood of developing distant metastasis is associated with high-grade tumors, such as adenoid cystic carcinoma, salivary duct carcinoma, high-grade mucoepidermoid carcinoma and tumors located in the submandibular gland, posterior tongue and pharyngeal tumors.
  • [MeSH-minor] Aged. Bone Neoplasms / secondary. Brain Neoplasms / secondary. Carcinoma, Acinar Cell / pathology. Carcinoma, Acinar Cell / secondary. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / secondary. Carcinoma, Mucoepidermoid / pathology. Carcinoma, Mucoepidermoid / secondary. Fatal Outcome. Humans. Immunohistochemistry. Incidence. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Male. Parotid Gland / pathology. Parotid Gland / surgery. Salivary Ducts / pathology. Tomography, X-Ray Computed

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  • (PMID = 16608783.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 32
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75. Hotte SJ, Winquist EW, Lamont E, MacKenzie M, Vokes E, Chen EX, Brown S, Pond GR, Murgo A, Siu LL: Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit: a Princess Margaret Hospital phase II consortium study. J Clin Oncol; 2005 Jan 20;23(3):585-90
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  • [Title] Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit: a Princess Margaret Hospital phase II consortium study.
  • PURPOSE: This study aimed to assess the antitumor activity of imatinib in adenoid cystic carcinoma (ACC) of the salivary gland expressing c-kit.
  • Fourteen patients had lung metastases, 14 had prior radiotherapy, and six had prior chemotherapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / drug therapy. Piperazines / therapeutic use. Proto-Oncogene Proteins c-kit / biosynthesis. Pyrimidines / therapeutic use. Salivary Gland Neoplasms / drug therapy

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  • [CommentIn] J Clin Oncol. 2005 Sep 1;23(25):6271-3; author reply 6273-4 [16135502.001]
  • (PMID = 15659505.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CM / N01 CM 17102-01; United States / NCI NIH HHS / CM / N01 CM 17107-01
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Biomarkers, Tumor; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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81. Shamim T, Varghese VI, Shameena PM, Sudha S: Primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis: a case report. J Oral Sci; 2008 Mar;50(1):95-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis: a case report.
  • Intraosseous adenoid cystic carcinoma is an extremely rare neoplasm with only 17 cases reported previously.
  • A case of primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis in a 45-year-old man is reported, together with a brief review of the literature.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology. Solitary Pulmonary Nodule / secondary
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 18403891.001).
  • [ISSN] 1343-4934
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 10
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82. Kumar T, Patel N, Talwar A: Spontaneous regression of thoracic malignancies. Respir Med; 2010 Oct;104(10):1543-50
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  • Using a modified Everson and Cole criterion we developed to define spontaneous regression, this search was refined for true spontaneous regression of primary and metastatic thoracic malignancies.
  • RESULTS: Only 5 cases in the literature involved spontaneous regression of a primary thoracic malignancy.
  • These include pleural mesothelioma, primary lung cancer and adenoid cystic carcinoma.
  • 71 cases involved true spontaneous regression of metastatic thoracic neoplasms, of which 5 cases showed regression of the primary extrapulmonary tumors along with the pulmonary metastasis.
  • Thoracic metastasis from renal cell carcinoma was the most common malignancy found to regress spontaneously.
  • CONCLUSION: Spontaneous regression of primary thoracic malignancy is rare.
  • Renal cell carcinoma accounts for most reported cases.
  • [MeSH-major] Carcinoma, Renal Cell / epidemiology. Kidney Neoplasms / epidemiology. Neoplasm Regression, Spontaneous. Pleural Neoplasms / epidemiology. Thoracic Neoplasms / epidemiology

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  • (PMID = 20580882.001).
  • [ISSN] 1532-3064
  • [Journal-full-title] Respiratory medicine
  • [ISO-abbreviation] Respir Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 81
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83. Hu JA, Li Y, Fang J: Effect of ERK inhibitor on pulmonary metastasis of inoculated human adenoid cystic carcinoma cells in nude mice. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jan;109(1):117-23
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  • [Title] Effect of ERK inhibitor on pulmonary metastasis of inoculated human adenoid cystic carcinoma cells in nude mice.
  • In this study, we detected the expression of phosphylated ERK1/2 in human salivary adenoid cystic carcinoma (SACC) by immunohistochemical method, the effect of various concentrations of PD98059 on the growth of ACC-M cells (a cell line of human adenoid cystic carcinoma of the salivary glands) by MTT assay, and the effect of PD98059 on the lung metastasis of inoculated ACC-M cells in nude mice.
  • The results showed that the phosphylated ERK1/2 was overexpressed in SACC, the ACC-M cell line proliferation was inhibited by PD98059, and the lung metastasis level was reduced by PD98059, indicating that ERK may be a key molecule in targeted therapy of adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / enzymology. Carcinoma, Adenoid Cystic / secondary. Extracellular Signal-Regulated MAP Kinases / antagonists & inhibitors. Lung Neoplasms / enzymology. Lung Neoplasms / secondary. Protein Kinase Inhibitors / pharmacology. Salivary Gland Neoplasms / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20123382.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one; 0 / Flavonoids; 0 / Protein Kinase Inhibitors; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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84. Patel AA, Gupta D, Seligson D, Hattab EM, Balis UJ, Ulbright TM, Kohane IS, Berman JJ, Gilbertson JR, Dry S, Schirripa O, Yu H, Becich MJ, Parwani AV, Shared Pathology Informatics Network: Availability and quality of paraffin blocks identified in pathology archives: a multi-institutional study by the Shared Pathology Informatics Network (SPIN). BMC Cancer; 2007 Feb 28;7:37
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  • Each site generated a list of 100 common tumor cases (25 cases each of breast adenocarcinoma, colonic adenocarcinoma, lung squamous carcinoma, and prostate adenocarcinoma) and 100 rare tumor cases (25 cases each of adrenal cortical carcinoma, gastro-intestinal stromal tumor [GIST], adenoid cystic carcinoma, and mycosis fungoides) using a combination of Tumor Registry, laboratory information system (LIS) and/or SPIN-related tools.
  • Retrieval rate (tumor blocks) from all centers for common tumors was 73% with mean largest tumor size of 1.49 cm; retrieval (tumor blocks) was highest-lung (84%) and lowest-prostate (54%).
  • Retrieval rate (tumor blocks) from all centers for rare tumors was 66% with mean largest tumor size of 1.56 cm; retrieval (tumor blocks) was highest for GIST (72%) and lowest for adenoid cystic carcinoma (58%).

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  • (PMID = 17386082.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01CA091343; United States / NCI NIH HHS / CA / U01 CA091429; United States / NCI NIH HHS / CA / U01CA091429; United States / NCI NIH HHS / CA / P30 CA016042; United States / NCI NIH HHS / CA / U01 CA091343; United States / NCI NIH HHS / CA / UO1CA91338-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1810540
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85. Ahn Y, Chang H, Lim YS, Hah JH, Kwon TK, Sung MW, Kim KH: Primary tracheal tumors: review of 37 cases. J Thorac Oncol; 2009 May;4(5):635-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary tracheal tumors: review of 37 cases.
  • INTRODUCTION: Primary tracheal tumors are rare, and composed of various benign and malignant pathologies.
  • The aims of this study were to establish the clinical manifestations and treatment outcomes of primary tracheal tumors and explore the prognostic variables for malignant tracheal tumors.
  • Squamous cell carcinomas (n = 11) and adenoid cystic carcinomas (n = 9) comprised most of the malignant tumors.
  • Five-year overall survival rate was 41.1% for squamous cell carcinoma and 45.7% for adenoid cystic carcinoma and no statistically significant difference (p = 0.673) was observed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / pathology. Papilloma / pathology. Tracheal Neoplasms / pathology

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  • (PMID = 19357541.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Macarenco RS, Uphoff TS, Gilmer HF, Jenkins RB, Thibodeau SN, Lewis JE, Molina JR, Yang P, Aubry MC: Salivary gland-type lung carcinomas: an EGFR immunohistochemical, molecular genetic, and mutational analysis study. Mod Pathol; 2008 Sep;21(9):1168-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland-type lung carcinomas: an EGFR immunohistochemical, molecular genetic, and mutational analysis study.
  • Salivary gland-type lung carcinomas are uncommon neoplasms of the lung, the two most common being adenoid cystic carcinoma and mucoepidermoid carcinoma.
  • Although they usually have an indolent behavior, adenoid cystic carcinomas can be more aggressive, with 5-year survival as low as 55%.
  • In contrast to the most common subtypes of lung carcinomas, epidermal growth factor receptor studies have not been carried out in this group of tumors.
  • Herein we report a series of 24 cases (12 adenoid cystic and 12 mucoepidermoid carcinomas) tested for epidermal growth factor receptor protein expression, epidermal growth factor receptor gene copy gains, and epidermal growth factor receptor gene mutational status, through immunohistochemistry, fluorescence in situ hybridization, and sequencing of the exons 18-21, respectively.
  • Overall, 91 and 92% of the adenoid cystic carcinomas and mucoepidermoid carcinomas expressed epidermal growth factor receptor protein.
  • Chromosome 7 polysomy occurred in 25% of the cases (four adenoid cystic carcinomas and two mucoepidermoid carcinomas).
  • Immunoexpression of epidermal growth factor receptor in salivary gland-type lung carcinomas is not related to epidermal growth factor receptor gene copy number or mutational status.

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  • (PMID = 18587327.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA090628-08; United States / NCI NIH HHS / CA / K12 CA090628; United States / NCI NIH HHS / CA / K12 CA090628-08
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ NIHMS121772; NLM/ PMC2752817
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87. Yu T, Gao QH, Wang XY, Wen YM, Li LJ: Malignant sublingual gland tumors: a retrospective clinicopathologic study of 28 cases. Oncology; 2007;72(1-2):39-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eighteen cases (64.3%) were adenoid cystic carcinoma; 16 (57.1%) cases were clinically staged as III-IV.
  • Adenoid cystic carcinoma was mainly of the histologic type, and the other histologic classifications included mucoepidermoid carcinoma, myoepithelial carcinoma, polymorphous low-grade adenocarcinoma, adenocarcinoma and malignant pleomorphic adenoma.
  • Pulmonary metastasis and tumor recurrence were the main death reasons.
  • CONCLUSIONS: Malignant sublingual gland tumors are extremely rare and most are adenoid cystic carcinoma.
  • For adenoid cystic carcinoma, hematogenous spread is common, and pulmonary metastasis is a common pathway of the distant metastasis.
  • For some patients having lung metastasis, regional control is also important as there are some examples of patients surviving many years with asymptomatic pulmonary metastases.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Sublingual Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Cause of Death. Female. Humans. Lung Neoplasms / mortality. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Prognosis. Retrospective Studies

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  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17998789.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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88. Ali TZ, Epstein JI: Basal cell carcinoma of the prostate: a clinicopathologic study of 29 cases. Am J Surg Pathol; 2007 May;31(5):697-705
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  • [Title] Basal cell carcinoma of the prostate: a clinicopathologic study of 29 cases.
  • We studied 29 cases of basal cell carcinoma of the prostate including what others call adenoid cystic carcinoma of the prostate.
  • The most common methods of diagnosis was transurethral resection (TURP) (n=29) and needle biopsy (n=9).
  • In 28/29 cases, slides were reviewed and 24 (86%) cases showed more than 1 pattern: adenoid cysticlike (AC-P) pattern and small solid nests with peripheral palisading were the most predominant patterns, each seen in 18 cases (64%).
  • Metastases developed in 4/29 patients: 1 in lung, 1 in lung and liver, 1 in lung, bone and liver, 1 in penile urethra.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 17460452.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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89. Ozkara SK, Turan G: Fine needle aspiration cytopathology of primary solid adenoid cystic carcinoma of the lung: a case report. Acta Cytol; 2009 Nov-Dec;53(6):707-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytopathology of primary solid adenoid cystic carcinoma of the lung: a case report.
  • BACKGROUND: Adenoid cystic carcinoma (ACC) is a rare, distinctive salivary gland malignant neoplasm arising infrequently as a primary tumor in the lung.
  • Cytomorphology of lung primary ACC has been rarely reported.
  • To the best of our knowledge, cytopathologic features of the solid type of ACC have not been described as a primary lung tumor.
  • CASE: A case of solid-type primary pulmonary ACC arising in the upper segment of the left mainstem bronchus, suggestively diagnosed cytopathologically by bronchoscope-guided fine needle aspiration (FNA), is presented.
  • Cytopathologic differential diagnoses of ACC with other, more common primary neoplasms of the lung are discussed.
  • CONCLUSION: A preoperative cytopathologic diagnosis of poorly differentiated primary pulmonary ACC can enhance surgical planning and success of tumor resection.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Lung / pathology. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology

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  • (PMID = 20014565.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Bobbio A, Copelli C, Ampollini L, Bianchi B, Carbognani P, Bettati S, Sesenna E, Rusca M: Lung metastasis resection of adenoid cystic carcinoma of salivary glands. Eur J Cardiothorac Surg; 2008 May;33(5):790-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lung metastasis resection of adenoid cystic carcinoma of salivary glands.
  • BACKGROUND: Adenoid cystic carcinoma is a rare tumour originating from the exocrine mucous glands, known for its high propensity for distant metastases.
  • The value of lung metastasis resection from adenoid cystic carcinoma of salivary glands origin is evaluated.
  • METHODS: A retrospective study was conducted on patients undergoing surgery for primary adenoid cystic carcinoma of the salivary glands between 1982 and 2006.
  • Patients were excluded who had primary tumour macroscopic incomplete resection or were lost at follow-up.
  • Nine patients who presented isolated lung recurrence underwent complete lung metastasectomy.
  • RESULTS: Twenty-six men and 24 women with a median age of 57 years (range 33-79) underwent radical surgery for adenoid cystic carcinoma during the study period.
  • Nine patients with a median free interval time of 5 years (range 1-12) underwent lung metastasectomy: five had single metastasis resection, one multiple mono-pulmonary and three multiple and bilateral.
  • In six of these patients a new disease recurrence was noted: four patients underwent further lung metastasectomy, but in all of them progression of the disease was observed.
  • CONCLUSIONS: Patients with adenoid cystic carcinoma could be frequently encountered with disease recurrence confined to the lung.
  • The impact of complete lung metastasis resection on the course of the disease, however, is yet to be determined.
  • [MeSH-major] Lung Neoplasms / secondary. Lung Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / secondary. Carcinoma, Adenoid Cystic / surgery. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Linear Models. Male. Middle Aged. Retrospective Studies. Survival Rate

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  • (PMID = 18343149.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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96. Xu Q, Liu X, Chen W, Zhang Z: Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference. J Transl Med; 2010;8:136
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  • [Title] Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference.
  • BACKGROUND: Adenoid cystic carcinoma is one of the most common types of salivary gland cancers.
  • The poor long-term prognosis for patients with adenoid cystic carcinoma is mainly due to local recurrence and distant metastasis.
  • The aim of this study was to analyze the relationship between ADAM 10 and the invasive and metastatic potentials as well as the proliferation capability of adenoid cystic carcinoma cells in vitro and in vivo.
  • METHODS: Immunohistochemistry and Western blot analysis were applied to detect ADAM 10 expression levels in metastatic cancer tissues, corresponding primary adenoid cystic carcinoma tissues, adenoid cystic carcinoma cell lines with high metastatic potential, and adenoid cystic carcinoma cell lines with low metastatic potential.
  • RNA interference was used to knockdown ADAM 10 expression in adenoid cystic carcinoma cell lines with high metastatic potential.
  • RESULTS: It was observed that ADAM 10 was expressed at a significantly higher level in metastatic cancer tissues and in adenoid cystic carcinoma cell lines with high metastatic potential than in corresponding primary adenoid cystic carcinomas and adenoid cystic carcinoma cell lines with low metastatic potential.
  • Additionally, silencing of ADAM 10 resulted in inhibition of cell growth and invasion in vitro as well as inhibition of cancer metastasis in an experimental murine model of lung metastases in vivo.
  • CONCLUSIONS: These studies suggested that ADAM 10 plays an important role in regulating proliferation and metastasis of adenoid cystic carcinoma cells.
  • ADAM 10 is potentially an important therapeutic target for the prevention of tumor metastases in adenoid cystic carcinoma.
  • [MeSH-major] ADAM Proteins / metabolism. Amyloid Precursor Protein Secretases / metabolism. Carcinoma, Adenoid Cystic / enzymology. Carcinoma, Adenoid Cystic / pathology. Membrane Proteins / metabolism. RNA Interference

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  • (PMID = 21171968.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / RNA, Messenger; EC 3.4.- / Amyloid Precursor Protein Secretases; EC 3.4.24.- / ADAM Proteins; EC 3.4.24.81 / ADAM10 protein, human
  • [Other-IDs] NLM/ PMC3017514
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97. Palanichamy MG, Zhang YP: Potential pitfalls in MitoChip detected tumor-specific somatic mutations: a call for caution when interpreting patient data. BMC Cancer; 2010;10:597

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This study examined mitochondrial sequence variants demonstrated in cancer patients, and assessed the reliability of using detected patterns of polymorphisms in the early diagnosis of cancer.
  • METHODS: Published entire mitochondrial genomes from head and neck, adenoid cystic carcinoma, sessile serrated adenoma, and lung primary tumor from clinical patients were examined in a phylogenetic context and compared with known, naturally occurring mutations which characterize different populations.
  • RESULTS: The phylogenetic linkage analysis of whole arrays of mtDNA mutations from patient cancerous and non-cancerous tissue confirmed that artificial recombination events occurred in studies of head and neck, adenoid cystic carcinoma, sessile serrated adenoma, and lung primary tumor.
  • [MeSH-minor] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Genetic Techniques. Genome. Head and Neck Neoplasms / genetics. Humans. Oligonucleotide Array Sequence Analysis. Phylogeny. Reactive Oxygen Species

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  • (PMID = 21034508.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; 0 / Reactive Oxygen Species
  • [Other-IDs] NLM/ PMC2988032
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98. Qin M, Fu Y, Yu D, Xu S, Han M, Wang Z: [Diagnosis and treatment of tracheal or bronchuotracheal adenoid cystic carcinoma]. Zhongguo Fei Ai Za Zhi; 2010 Jun;13(6):628-31
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and treatment of tracheal or bronchuotracheal adenoid cystic carcinoma].
  • BACKGROUND AND OBJECTIVE: Adenoid cystic carcinoma is primary bronchopulmonary carcinoma with low malignancy, and 43 patients treated in the past 50 years in our hospital were retrospectively studied.
  • The aim of this study is to discuss the clinical symptoms, pathologic characteristic and therapeutic method of primary tracheal or bronchuotracheal adenoid cystic carcinoma.
  • METHODS: This study summarized total 43 patients of primary tracheal or bronchus adenoid cystic carcinoma treated in our hospital from Jan.
  • CONCLUSION: Primary tracheal or bronchus adenoid cystic carcinoma are rare and low malignancy carcinoma.
  • [MeSH-major] Bronchial Neoplasms / surgery. Carcinoma, Adenoid Cystic / surgery. Tracheal Neoplasms / surgery

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  • (PMID = 20681452.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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99. Huang FH, Tian Z, Zhang CY, Xia RH, Li J: [Effect of DNA methyltransferases 1 inhibition on proliferation, invasion, and metastasis in ACC-M line]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2009 Dec;44(12):745-50
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To investigate the effect of DNA methyltransferases 1 (DNMT-1) inhibition on the ACC-M cells in vitro and in vivo and discuss the role of DNMT-1 in the development, invasion and metastasis of salivary adenoid cystic carcinoma (SACC).
  • In vivo, the subcutaneous tumor forming rate (6/10), volume [(2.18 +/- 0.83) mm(3)], weight [(0.0156 +/- 0.0046) g] of ACC-M cells was also significantly lower than that of blank [10/10, (155.44 +/- 1.67) mm(3), (0.0724 +/- 0.0157) g], empty load control [10/10, (147.46 +/- 1.73) mm(3), (0.0729 +/- 0.0177) g], P < 0.05, but the rate of lung metastasis was not significantly different among these groups (P > 0.05), and the masses (2.0 +/- 0.5), diameter (70.0 +/- 20.3) microm of ACC-M cells was significantly lower than that of blank [(28.0 +/- 5.5), (195 +/- 25.4) microm], empty load control [(27.0 +/- 4.5), (190.0 +/- 19.9) microm], P < 0.05.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Repressor Proteins / antagonists & inhibitors. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Animals. Cell Line, Tumor. Humans. Lung Neoplasms / secondary. Mice. Mice, Nude. Neoplasm Invasiveness

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  • (PMID = 20193293.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DMAP1 protein, human; 0 / Repressor Proteins
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100. Bölükbas S, Schirren J: Parenchyma-sparing bronchial sleeve resections in trauma, benign and malign diseases. Thorac Cardiovasc Surg; 2010 Feb;58(1):32-7
MedlinePlus Health Information. consumer health - Bronchial Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: From January 1999 through December 2008, 19 patients (11 male) underwent bronchial sleeve resection without removal of pulmonary parenchyma.
  • Indications were carcinoid tumors (n = 14), adenoid cystic carcinoma (n = 1), non-small cell lung cancer (n = 1), blunt chest trauma (n = 2) and stenosis (n = 1).
  • Resections were complete except for the resection of the adenoid cystic carcinoma (n = 1, R1 resection).
  • [MeSH-major] Bronchi / surgery. Bronchial Diseases / surgery. Pulmonary Surgical Procedures / methods

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  • (PMID = 20072974.001).
  • [ISSN] 1439-1902
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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