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1. Barrera JE, Shroyer KR, Said S, Hoernig G, Melrose R, Freedman PD, Wright TA, Greer RO: Estrogen and progesterone receptor and p53 gene expression in adenoid cystic cancer. Head Neck Pathol; 2008 Mar;2(1):13-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Estrogen and progesterone receptor and p53 gene expression in adenoid cystic cancer.
  • OBJECTIVES: The current study examined the role of estrogen receptors (ER), progesterone receptors (PR) and p53 expression in adenoid cystic carcinoma (ACC) to determine if simple expression or possible overexpression of these products might influence the development and natural course of this cancer.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Gene Expression Regulation, Neoplastic / physiology. Genes, p53 / physiology. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 20614336.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ PMC2807605
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Estrogen and progesterone receptors / p53 gene
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2. Sharma K, Rathi AK, Khurana N, Mukherji A, Kumar V, Singh K, Bahadur AK: A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi. Indian J Cancer; 2010 Oct-Dec;47(4):424-9
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  • [Title] A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi.
  • CONTEXT: Adenoid cystic carcinoma (ACC) is a rare neoplasm that usually arises from the salivary, lacrimal, or other exocrine glands.
  • AIM: To analyze the presentation and natural history of cases of adenoid cystic tumors of salivary glands in our institution; and to compare with the existing literature.
  • Radiotherapy adjuvant to surgery improves local control in locally advanced disease.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 21131757.001).
  • [ISSN] 1998-4774
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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3. Sheen-Chen SM, Eng HL, Chen WJ, Cheng YF, Ko SF: Adenoid cystic carcinoma of the breast: truly uncommon or easily overlooked? Anticancer Res; 2005 Jan-Feb;25(1B):455-8
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  • [Title] Adenoid cystic carcinoma of the breast: truly uncommon or easily overlooked?
  • BACKGROUND: Adenoid cystic carcinoma of the breast is an uncommon histologic form of breast cancer, comprising in most series less than 1% of all mammary cancers.
  • The final pathological report was adenoid cystic carcinoma.
  • Histopathological examination showed typical features of an adenoid cystic carcinoma.
  • CONCLUSION: Adenoid cystic carcinoma of the breast fails to show the typical appearance of invasive ductal carcinoma on both mammogram and ultrasonography, probably due to its relatively well-defined nature with less surrounding architectural disruption and fibrosis.
  • Hence a "negative" finding or a benign-looking breast lesion on mammography cannot completely exclude the existence of this disease.
  • The presence of a painful breast lesion without obvious inflammatory evidence while compressed is a meaningful clue, which should lead to the suspicion of adenoid cystic carcinoma of the breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Mammography / methods

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  • (PMID = 15816611.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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4. Rabban JT, Swain RS, Zaloudek CJ, Chase DR, Chen YY: Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers. Mod Pathol; 2006 Oct;19(10):1351-7
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  • [Title] Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers.
  • Adenoid cystic carcinoma of the breast is a rare neoplasm whose cribriform architecture may mimic invasive cribriform carcinoma, cribriform ductal carcinoma in situ, and collagenous spherulosis.
  • The diagnosis may be even more challenging in needle core biopsies.
  • Immunohistochemical expression of p63 and c-kit distinguishes adenoid cystic carcinoma from invasive cribriform carcinoma and ductal carcinoma in situ.
  • A formal comparison of the immunophenotype of adenoid cystic carcinoma to collagenous spherulosis has not been reported.
  • We evaluated smooth muscle actin, p63, calponin, smooth muscle myosin heavy chain, as well as c-kit, in nine cases of cribriform pattern adenoid cystic carcinoma of the breast in comparison to 12 cases of collagenous spherulosis.
  • Both entities strongly expressed p63 and smooth muscle actin; in adenoid cystic carcinoma, the basaloid myoepithelial-like tumor cells expressed these markers, but the ductular epithelial cells did not.
  • Neither calponin nor smooth muscle myosin heavy chain was expressed in adenoid cystic carcinoma but both were strongly expressed in collagenous spherulosis.
  • Whereas the ductular epithelial cells of adenoid cystic carcinoma were positive for c-kit in all cases, collagenous spherulosis was negative for c-kit.
  • Positive p63 expression by a cribriform breast lesion is not sufficiently specific to confirm a diagnosis of adenoid cystic carcinoma.
  • A broader panel that includes calponin or smooth muscle myosin heavy chain and c-kit is required to exclude collagenous spherulosis in settings in which the distinctive morphologic features that separate these entities are not conspicuously present.
  • [MeSH-major] Biomarkers, Tumor / analysis. Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Collagen. Epithelial Cells / pathology
  • [MeSH-minor] Actins / analysis. Calcium-Binding Proteins / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Membrane Proteins / analysis. Microfilament Proteins / analysis. Myosin Heavy Chains / analysis. Proto-Oncogene Proteins c-kit / analysis. Retrospective Studies

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  • (PMID = 16810311.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Calcium-Binding Proteins; 0 / Membrane Proteins; 0 / Microfilament Proteins; 0 / calponin; 9007-34-5 / Collagen; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.6.4.1 / Myosin Heavy Chains
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5. de Luis E, Apesteguía L, Noguera JJ, Pina L, Martínez-Regueira F, Miguel C, Sáenz J: [Adenoid cystic carcinoma of the breast]. Radiologia; 2006 Jul-Aug;48(4):235-40
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  • [Title] [Adenoid cystic carcinoma of the breast].
  • [Transliterated title] Carcinoma adenoide quístico de mama.
  • OBJECTIVE: To review the clinical presentation and imaging findings of adenoid cystic carcinoma (ACC).
  • Four patients remain asymptomatic at present (mean follow-up = 64 months) and one presented lung and liver metastes twelve years after the diagnosis of ACC.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Adenoid Cystic / diagnosis

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  • (PMID = 17058651.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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6. Vattemi E, Graiff C, Sava T, Pedersini R, Caldara A, Mandarà M: Systemic therapies for recurrent and/or metastatic salivary gland cancers. Expert Rev Anticancer Ther; 2008 Mar;8(3):393-402
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Salivary gland carcinomas are rare cancers, comprising 1-5% of head and neck cancers.
  • The most commonly histopathologic types are mucoepidermoid cancer, adenoid cystic cancer and adenocarcinomas.
  • Chemotherapy is reserved for palliative treatment of metastatic disease but results are disappointing.

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  • (PMID = 18366287.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Hormonal; 0 / Benzamides; 0 / Boronic Acids; 0 / Piperazines; 0 / Pyrazines; 0 / Pyrimidines; 0 / Quinazolines; 0VUA21238F / lapatinib; 69G8BD63PP / Bortezomib; 8A1O1M485B / Imatinib Mesylate; P188ANX8CK / Trastuzumab; PQX0D8J21J / Cetuximab; S65743JHBS / gefitinib
  • [Number-of-references] 56
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7. Boo H, Hogg JP: Nasal cavity neoplasms: a pictorial review. Curr Probl Diagn Radiol; 2010 Mar-Apr;39(2):54-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Retrospective case review of pathologically and clinically proven nasal cavity neoplasms are shown with multiple modalities including computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) to illustrate the findings and complement a succinct review of this category of disease.
  • Examples include squamous cell cancer, adenoid cystic cancer, esthesioneuroblastoma, inverted papilloma, juvenile nasal angiofibroma, melanoma, lymphoma, sarcoma, and benign nasal histiocytoma.
  • [MeSH-major] Nasal Cavity. Nose Neoplasms / diagnosis
  • [MeSH-minor] Angiofibroma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Squamous Cell / diagnosis. Chondrosarcoma / diagnosis. Diagnosis, Differential. Esthesioneuroblastoma, Olfactory / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Humans. Magnetic Resonance Imaging. Melanoma / diagnosis. Papilloma, Inverted / diagnosis. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20113866.001).
  • [ISSN] 1535-6302
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP: [Human kallikrein 13 expression in salivary gland tumors]. Int J Biol Markers; 2006 Apr-Jun;21(2):106-110

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic adenomas (PA), adenoid cystic carcinomas (ACC), polymorphous low grade adenocarcinomas (PLGA), acinic cell carcinomas (ACI), mucoepidermoid carcinomas (MEC) and adenocarcinomas not otherwise specified (ANOS) of both minor and major salivary glands were examined.

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  • (PMID = 28207129.001).
  • [ISSN] 1724-6008
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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9. Ozer E, Bapna S, Agrawal A, Schuller DE: Maxillary removal and reinsertion: a favorable approach for extensive anterior cranial base tumors. Otolaryngol Head Neck Surg; 2010 Mar;142(3):322-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SETTING: The Ohio State University Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute.
  • The most commonly encountered malignant neoplasm was squamous cell cancer (40.3%), followed by esthesioneuroblastoma (24.1%), adenoid cystic cancer (8%), and other neoplasms (27.4%).
  • Overall five-year survival for the patients with squamous cell carcinoma was 62 percent.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Cranial Fossa, Anterior. Otorhinolaryngologic Surgical Procedures / methods. Skull Base Neoplasms / surgery

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  • [Copyright] Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20172374.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Wang J, Wang R, Yang W: [Surgical management of nasal septum malignant tumor]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2005 Jul;19(14):636-7
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  • The pathology of nasal septum malignant tumor in our department were: seven cases with squamous cell carcinoma in (5 cases were primary, 2 cases were secondary), 4 cases with adenoid cystic carcinoma (3 cases were primary, 1 case was secondary), 3 cases with malignant melanoma, 1 case with adenocarcinoma, 1 case with mucoepidermoid carcinoma.
  • After follow up for 1-10 years, 1 case was undetected, 2 cases were dead (1 case with malignant melanoma, 1 case with secondary squamous cell cancer), 3 cases survive with tumor (1 case with squamous cell cancer, 1 case with secondary adenoid cystic cancer, 1 case with malignant melanoma).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Nasal Septum / surgery. Nose Neoplasms / surgery

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  • (PMID = 16248459.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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11. Pérez González R, Martín Sigüenza G, Alonso Alonso J, Alonso Orcajo N, González Palomino A, Guerra Camacho M, Casas Rubio C: [The adenoid cystic carcinoma]. An Otorrinolaringol Ibero Am; 2005;32(3):211-20
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  • [Title] [The adenoid cystic carcinoma].
  • [Transliterated title] Carcinoma adenoide quístico de CAE.
  • The adenoid cystic carcinoma arising in the external auditory canal is a rare tumor, as other malignant neoplasias of the EAC and middle ear.
  • The early diagnosis of these malignant tumors of the ear is very important to improve the prognosis.
  • In this sense, the clinic experience is frequently the most useful diagnosis instrument to suspect this pathology when we have a confrontation with chronic otorrea and otalgia, common presentation form of this disease.
  • In this report we show a new case of adenoid cystic carcinoma of external auditory canal and review the most significant medical literature existing in relationship with this pathology.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / radiography. Ear Neoplasms / pathology. Ear Neoplasms / radiography. Ear, External / pathology. Ear, External / radiography

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  • (PMID = 16001690.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 19
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12. Kallel R, Bahri Zouari I, Gouiaa N, Charfi S, Daoud E, Ayadi L, Makni S, Daoud J, Sellami Boudawara T: [Adenoid cystic carcinoma of the breast]. Cancer Radiother; 2009 Jul;13(4):323-8
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  • [Title] [Adenoid cystic carcinoma of the breast].
  • [Transliterated title] Carcinome adénoïde kystique du sein.
  • Adenoid cystic carcinoma of the breast is a rare neoplasm, accounting for only 0.1% of all malignant breast tumours.
  • The preoperative diagnosis is possible with fine-needle aspiration cytology.
  • The diagnosis is made by histological examination, presented a difficult differential diagnosis with cribriform carcinoma; so it is necessary to use histochemical or immunohistochemical techniques.
  • Compared to other locations, adenoid cystic carcinoma of the breast has a favorable prognosis.
  • The aim of our study is to describe the epidemiological, clinicopathological characteristics, the treatment and the prognosis of this rare type of breast tumour.
  • [MeSH-major] Breast Neoplasms. Carcinoma, Adenoid Cystic
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Combined Modality Therapy / methods. Diagnosis, Differential. Female. Humans. Middle Aged. Young Adult

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  • (PMID = 19464219.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 30
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13. Bonanno A, Esmaeli B, Nelson DV, Fingeret M, Weber RS: Social interaction and stigmatization of cancer patients with orbitofacial disfigurement. J Clin Oncol; 2009 May 20;27(15_suppl):e20659

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Social interaction and stigmatization of cancer patients with orbitofacial disfigurement.
  • : e20659 Background: Advances in cancer treatment extend the survival of orbitofacial cancer patients who undergo orbital exenteration.
  • Cancer diagnoses included lacrimal gland adenoid cystic ca. (n=3), conjunctival SCCA(n=3), and 1 each of conjunctival melanoma, eyelid sebaceous gland ca., lacrimal sac transitional cell ca., orbital adenoca., orbital neuroendocrine ca., and eyelid basal cell ca.
  • None were receiving active cancer therapy and none had cancer recurrence at interview time.
  • Health care professionals should be trained to address these problems through programs of social intervention for head and neck cancer survivors.

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  • (PMID = 27961618.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Falchook GS, Wheler JJ, Tannir NM, Naing A, Jackson E, Hong D, Lawhorn KN, Ng C, Amin H, Kurzrock R: Hypoxia-inducible factor-1α (HIF-1α) modulation in combination with anti-angiogenic therapy. J Clin Oncol; 2009 May 20;27(15_suppl):3555

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two partial responses were observed in patients with renal cell carcinoma (RCC) (Total patients with RCC = 6).
  • Minor responses or stable disease lasting ≥4 months was achieved in 8 patients, including RCC (1), breast (1), leiomyosarcoma (1), nasopharyngeal (2), hepatocellular (1), neuroendocrine (1), lacrimal gland adenocystic carcinoma (1).

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  • (PMID = 27961363.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Hoban CJ, Hoering A, Synold TW, Chung V, Gandara DR, Schott AF, Kingsbury L, Lew D, LoRusso PM, Gadgeel SM: Phase I evaluation of lapatinib and everolimus in patients with advanced malignancies: Southwest Oncology Group trial S0528. J Clin Oncol; 2009 May 20;27(15_suppl):3553

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  • Common tumors were breast (4), lung cancer (3), adenoid cystic (3).
  • None of the pts had a response but 11 pts (2 liver, 1 breast, 1 renal, 1 sarcoma, 2 adenoid cystic, 1 melanoma, 1 bladder, 1 NSCLC, 1 colorectal) had stable disease for 8 weeks or longer.

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  • (PMID = 27961366.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Kawaguchi K: Robotic radiosurgery for severe recurrent and primary head and neck cancer. J Clin Oncol; 2009 May 20;27(15_suppl):e17038

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Robotic radiosurgery for severe recurrent and primary head and neck cancer.
  • METHODS: Between March 2006 and January 2008, 22 patients with severe recurrent, previously treated with conventional methods, and 14 patients with primary lesions were treated with CK in the management of head and neck cancer.
  • All the patients had biopsy confirmation of disease prior to radiation therapy; rT2 (3 patients), rT3 (8), rT4 (9), T2 (5), T3 (3), T4 (6), N1 (4), N2b (3), M1 (1), tongue (11), mandibule (11), maxilla (6), maxillary sinus (4), soft palate (2), with sq. cell ca.(34), adenoid cystic ca.(1), fibrosarcoma (1).
  • Between the 4-6 month follow-up, 4 cases were performed additional CK treatment for the recurrent lesions, however, 3 patients with T4 tongue cancer were not cured.
  • Finally, the total control rate of the primary cases was 10/14 (71.4%), however, 8/9 (88.9%) primary cases except tongue cancer has been controlled treated by CK with chemotherapy.
  • There have been no seriously complications of treatment caused by CK except severe osteoradionecrosis of the 4 patients irradiated with maximum dose.
  • CONCLUSIONS: It is now possible with the development of CyberKnife Radiosurgery to improve our treatments of the local control in head and neck cancer.

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  • (PMID = 27961782.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Dong M, Ning Z, Newman MJ, Xu J, Dou G, Cao H, Shi Y, Gingras MA, Lu X, Feng F: Phase I study of chidamide (CS055/HBI-8000), a novel histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas. J Clin Oncol; 2009 May 20;27(15_suppl):3529

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 3529 Background: Chidamide (CS055/HBI-8000) is a new benzamide type of histone deacetylase (HDAC) inhibitor with low nanomolar activity against HDAC1, 2, 3 and 10.
  • 4 pts with T-cell lymphomas (4/5 evaluable) and 1 pt with submandibular adenoid cystic carcinoma achieved PR, and 11 pts (2 B-cell lymphomas and 9 solid tumors) experienced SD.

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  • (PMID = 27961317.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Hamlin PA, Aghajanian C, Younes A, Hong DS, Palladino MA, Longenecker AM, Lloyd GK, Hannah AL, Spear MA, Kurzrock R: First-in-human phase I study of the novel structure proteasome inhibitor NPI-0052. J Clin Oncol; 2009 May 20;27(15_suppl):3516

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Stable disease was observed in patients with cervical carcinoma (11 months; maximum response was 24%; PI increased with dose escalation), colorectal, hepatocellular, adenoid cystic, melanoma, granulosis cell and ovarian.

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  • (PMID = 27961302.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Perea Guerrero H, Frisancho Velarde O, Palomino Portilla A: [Primary adenoid cystic carcinoma of esophagus]. Rev Gastroenterol Peru; 2008 Jan-Mar;28(1):50-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary adenoid cystic carcinoma of esophagus].
  • [Transliterated title] Carcinoma adenoide quístico primario de esófago.
  • We presented the case of a man of 86 years with 6 months of progressive dysphagia, weight loss and edema of lower limbs.
  • The histological study revealed adenoid cystic carcinoma of esophagus, with positive inmunocytochemical to cytokeratin.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Esophageal Neoplasms

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  • (PMID = 18418449.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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20. Hou JL, Wu LY, Zhang HT, Li N, Yu GZ: [Clinicopathological characteristics of six patients with adenoid cystic carcinoma of the Bartholin gland]. Zhonghua Zhong Liu Za Zhi; 2010 Apr;32(4):290-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinicopathological characteristics of six patients with adenoid cystic carcinoma of the Bartholin gland].
  • OBJECTIVE: To evaluate the clinicopathological characteristics and treatment of adenoid cystic carcinoma of the Bartholin gland.
  • METHODS: The clinicopathological data of six patients with adenoid cystic carcinoma of the Bartholin gland were retrospectively analyzed.
  • RESULTS: All patients had definite pathological diagnosis.
  • Cribriform arrangement of tubules and gland-like elements and infiltration of perineural spaces were two main microscopic features of this type of tumor.
  • CONCLUSION: Adenoid cystic carcinoma of the Bartholin gland is a slow growing but locally very aggressive neoplasm with a high capacity for local recurrence and lung metastasis.
  • [MeSH-major] Bartholin's Glands / pathology. Carcinoma, Adenoid Cystic / surgery. Vulva / surgery. Vulvar Neoplasms / surgery

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  • (PMID = 20510082.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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21. Crestani S, Vellin JF, Nohra O, Gabrillargues J, Kemeny JL, Gilain L, Mom T: [Adenoid cystic carcinoma of the external auditory canal]. Ann Otolaryngol Chir Cervicofac; 2007 Dec;124(6):314-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma of the external auditory canal].
  • [Transliterated title] Carcinome adénoïde kystique du méat acoustique externe.
  • OBJECTIVES: To report a case of adenoid cystic carcinoma of the external auditory canal with petrous involvement.
  • MATERIAL AND METHODS: A 50-year-old woman was referred to our department for the management of a necrotizing external otitis.
  • Computed tomography and biopsy revealed an adenoid cystic carcinoma of the external auditory canal.
  • Adenoid cystic carcinoma of the external auditory canal is a rare tumor.
  • It's a special type of carcinoma developing from the ceruminous glands.
  • The adenoid cystic carcinoma is a rare neoplasm of the external auditory canal.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / radiography. Ear Neoplasms / radiography. Ear, External / pathology. Ear, External / radiography

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  • (PMID = 17521599.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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22. Farah-Klibi F, Ferchichi L, Kooli H, Ferjaoui M, Baltagi Ben Jilani S, Zermani R: [Adenoid cystic carcinoma of the trachea]. Rev Laryngol Otol Rhinol (Bord); 2007;128(1-2):101-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma of the trachea].
  • [Transliterated title] Carcinome adénoïde kystique de la trachée.
  • Cystic adenoid carcinoma of the trachea, also called cylindroma, is a rare malignant tumor accounting for 1% of all respiratory tract cancers.
  • OBJECTIVES: To recall through two observations and a review of the literature, various epidemiologic anatomical clinical aspects, and evolutionary of cystic glandular carcinome of the respiratory tracts.
  • We report 2 cases of cystic glandular carcinoma of the trachea.
  • CONCLUSION: Cystic adenoid carcinomas of the trachea are rare tumours.
  • Their diagnosis is based on the bronchial fibroscopy associated with the biopsy.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Tracheal Neoplasms / pathology

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  • (PMID = 17633678.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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23. Xu Q, Liu X, Cai Y, Yu Y, Chen W: RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells. Tumour Biol; 2010 Jun;31(3):217-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells.
  • A disintegrin and metalloproteinase 9 (ADAM9) is a type I transmembrane protein that has been associated with cancer development and metastases.
  • Here, we show that ADAM9 is highly expressed in metastatic cancer tissues and in an adenoid cystic carcinoma cell line with a high metastatic potential.
  • Using RNA interference for gene silencing, we show that ADAM9 is essential for in vitro cancer cell proliferation and invasion as well as in vivo cancer metastasis in an experimental murine model of lung metastases.
  • These data indicate that ADAM9 is potentially an important new therapeutic target for the prevention of tumor metastases in adenoid cystic carcinoma.
  • [MeSH-major] ADAM Proteins / antagonists & inhibitors. Carcinoma, Adenoid Cystic / therapy. Membrane Proteins / antagonists & inhibitors. RNA Interference

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  • (PMID = 20422344.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 3.4.24.- / ADAM Proteins; EC 3.4.24.- / ADAM9 protein, human
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24. Daa T, Yada N, Kashima K, Suzuki M, Yokoyama S: Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland. Mol Med Rep; 2009 Jan-Feb;2(1):13-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alteration of SMAD4 does not participate in tumorigenesis of adenoid cystic carcinoma of the salivary gland.
  • SMAD4, also known as DPC4 (deleted in pancreatic carcinoma 4) was initially identified as a tumor-suppressor gene.
  • It is located on 18q21, a region frequently deleted in pancreatic carcinoma.
  • Functionally inactivating mutation of the gene also occurs in many cases of pancreatic cancer.
  • Functional loss of SMAD4 is frequently detected not only in pancreatic carcinoma but also in colorectal carcinoma.
  • The purpose of this study was to elucidate the role of SMAD4 in adenoid cystic carcinoma of the salivary glands.
  • We examined 34 cases of adenoid cystic carcinoma for loss of heterozygosity (LOH) of the SMAD4 locus and for the existence of mutations of the gene.
  • In conclusion, the infrequent LOH of the SMAD4 gene locus and lack of SMAD4 mutations indicate that SMAD4 does not play a role in the tumorigenesis of adenoid cystic carcinoma of the salivary gland.

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  • (PMID = 21475783.001).
  • [ISSN] 1791-2997
  • [Journal-full-title] Molecular medicine reports
  • [ISO-abbreviation] Mol Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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25. Qing J, Zhang Q, Wei MW, Guo ZM: [Prognostic analysis of adenoid cystic carcinoma of major salivary glands of 64 cases]. Ai Zheng; 2006 Sep;25(9):1138-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Prognostic analysis of adenoid cystic carcinoma of major salivary glands of 64 cases].
  • BACKGROUND & OBJECTIVE: Adenoid cystic carcinoma of salivary glands is a kind of highly malignant tumor, and researches on the tumors originated from major salivary glands are rare.
  • This study was to investigate prognostic factors of adenoid cystic carcinoma of major salivary glands.
  • METHODS: Clinical records of 64 patients with adenoid cystic carcinoma of major salivary glands followed up for more than 7 years were reviewed.
  • CONCLUSION: Presence or absence of nerve invasion, histological subtype, clinical stage, and positive or negative surgical margin are the independent factors affecting the prognosis of patients with adenoid cystic carcinoma of salivary glands.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Salivary Gland Neoplasms / pathology

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  • (PMID = 16965658.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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26. Nishida M, Nasu K, Takai N, Miyakawa I, Kashima K: Adenoid cystic carcinoma of the uterine cervix. Int J Clin Oncol; 2005 Jun;10(3):198-200
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the uterine cervix.
  • Adenoid cystic carcinoma of the uterine cervix is a rare and peculiar variant of adenocarcinoma.
  • We report a case of adenoid cystic carcinoma stage IIIb that was successfully treated with radiotherapy.
  • Generally, radiotherapy and chemotherapy are chosen as the first treatment, because this cancer is seen most commonly in the elderly.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Uterine Cervical Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Disease-Free Survival. Female. Humans. Treatment Outcome

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  • (PMID = 15990970.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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27. Popa I, Welt L, Constantin G, Popa E, Bordea A, Burcoş T, Iosif C, Angelescu N: [Adenoid cystic carcinoma of the breast--two case reports]. Chirurgia (Bucur); 2010 Nov-Dec;105(6):827-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma of the breast--two case reports].
  • [Transliterated title] Carcinom adenoid chistic mamar--prezentare a două cazuri.
  • Adenoid cystic carcinoma is a rare type of breast carcinoma with a good prognosis.
  • It represents less than 0,1% of breast carcinomas.
  • We present two cases of adenoid cystic carcinoma diagnosed in the Surgical Department of Coltea Hospital in the last 3 years.
  • The first case is a 66 years old patient with a breast tumor that has clinical and imagistic features compatible with a benign diagnosis.
  • The frozen sections established the diagnosis of adenoid cystic carcinoma, confirmed by histopathologic examination of paraffin embedded tissue and immunohistochemistry.
  • The second case is a 68 years old patient with a breast tumor located in the central quadrant of the left breast, with skin infiltration.
  • Preoperatory fine needle aspiration is sugestive of a papillary tumor, so the cytologic exam cannot establish malignancy.
  • The frozen sections established the diagnosis of ductal invasive carcinoma and histopathologic examination of paraffin embedded tissue and immunohistochemistry established the diagnosis of adenoid cystic carcinoma associated with ductal invasive carcinoma grade I and adenomyoepitelioma.
  • [MeSH-major] Adenomyoepithelioma / pathology. Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Carcinoma, Ductal, Breast / pathology. Diagnosis, Differential. Female. Humans. Lymph Node Excision. Mastectomy. Neoplasm Staging. Treatment Outcome

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  • (PMID = 21355181.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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28. Singh S, Gokkulakrishnan, Jain J, Pathak S, Singh KT: Adenoid cystic carcinoma of buccal mucosa. J Maxillofac Oral Surg; 2010 Sep;9(3):273-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of buccal mucosa.
  • Adenoid cystic carcinoma is a malignant neoplasm most commonly originating in salivary glands of head and neck region.
  • Here we present a case report of a 50 year old male who was diagnosed with adenoid cystic carcinoma of the right buccal mucosa.

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  • (PMID = 22190804.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177452
  • [Keywords] NOTNLM ; Adenoid cystic / Carcinoma / Malignant neoplasm / Salivary gland disorder
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29. Dardick I, Daley TD, McComb RJ: Sialoblastoma in adults: distinction from adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jan;109(1):109-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sialoblastoma in adults: distinction from adenoid cystic carcinoma.
  • Essentially, sialoblastoma is a disease of infancy with the oldest case presenting at 4 years of age.
  • No adult cases have been reported with a specific diagnosis of sialoblastoma.
  • If even focal cribriforming were present, such cases have undoubtedly been diagnosed as adenoid cystic carcinoma.
  • Sialoblastoma, whether in a child or adult with or without a cribriform growth pattern, appears to have a more favorable prognosis than adenoid cystic carcinoma.
  • Aspects of the histological differential diagnosis of these 2 tumors are discussed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Palatal Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Facial Paralysis / etiology. Female. Humans. Male. Middle Aged. Palate, Hard / pathology. Parotid Neoplasms / complications. Parotid Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 19880331.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Lee DJ, Ahn HK, Koh ES, Rho YS, Chu HR: Necrotizing sialometaplasia accompanied by adenoid cystic carcinoma on the soft palate. Clin Exp Otorhinolaryngol; 2009 Mar;2(1):48-51
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Necrotizing sialometaplasia accompanied by adenoid cystic carcinoma on the soft palate.
  • Necrotizing Sialometaplasia (NS) is a benign, self-limiting inflammatory disease of the mucus-secreting glands, and this illness mainly involves the minor salivary glands.
  • We present here a case of necrotizing sialometaplasia on the soft palate, and this was accompanied by adenoid cystic carcinoma.

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  • [Cites] Br J Radiol. 2008 Jun;81(966):e173-5 [18487385.001]
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  • (PMID = 19434292.001).
  • [ISSN] 1976-8710
  • [Journal-full-title] Clinical and experimental otorhinolaryngology
  • [ISO-abbreviation] Clin Exp Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2671828
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Necrotizing sialometaplasia
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31. Crisi GM, Marconi SA, Makari-Judson G, Goulart RA: Expression of c-kit in adenoid cystic carcinoma of the breast. Am J Clin Pathol; 2005 Nov;124(5):733-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of c-kit in adenoid cystic carcinoma of the breast.
  • Breast adenoid cystic carcinoma (BACC) is a biologically distinct tumor with morphologic mimickers, which might make accurate classification problematic.
  • Because c-kit expression has been reported in adenoid cystic carcinoma of various anatomic sites, we evaluated BACC for c-kit by immunohistochemical analysis, comparing the findings to similarly stained mimickers.
  • Tested cases included 6 BACCs, 15 low-grade infiltrating ductal carcinomas (LGIDCs) chosen as potential mimickers, and 15 head-neck adenoid cystic carcinomas (HNACCs).
  • Immunohistochemical evaluation for c-kit might aid in accurately classifying carcinomas with histologic features overlapping adenoid cystic carcinoma and LGIDC.
  • [MeSH-major] Breast Neoplasms / chemistry. Carcinoma, Adenoid Cystic / chemistry. Proto-Oncogene Proteins c-kit / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Ductal, Breast / chemistry. Carcinoma, Ductal, Breast / pathology. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 16203286.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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32. Liang S, Fan M: Immunotherapy for adenoid cystic carcinoma of salivary glands: cancer/testis antigens and 5-aza-2'-deoxycytidine. Med Hypotheses; 2009 Nov;73(5):768-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunotherapy for adenoid cystic carcinoma of salivary glands: cancer/testis antigens and 5-aza-2'-deoxycytidine.
  • Adenoid cystic carcinoma of salivary glands is the epithelial tumor.
  • There are amount of malignant occurrences of adenoid cystic carcinoma of salivary glands in the head and neck area.
  • Cancer/testis antigens can be found in various malignant tumors, normal adult testis and occasionally placenta, but not in the other normal adult tissues.
  • This characteristic makes Cancer/testis antigens as potential markers to be applied in immunotherapeutic strategies against cancer.
  • It has been shown that in different tumors, the expression of certain Cancer/testis antigens is activated treated with 5-aza-CdR via the demethylation of their promoter CpG islands.
  • It is logical that multiple Cancer/testis antigens may correlate with the clinicopathologic factors of adenoid cystic carcinoma of salivary glands and be the potential markers of prognosis treated with 5-aza-CdR.
  • So the hypothesis will provide the new direction that we can use Cancer/testis antigens as candidate antigens for adenoid cystic carcinoma of salivary glands immunotherapy due to the high expression rate activated with 5-aza-CdR.
  • [MeSH-major] Antigens, Neoplasm / immunology. Carcinoma, Adenoid Cystic / therapy. Immunotherapy. Salivary Gland Neoplasms / therapy. Testis / immunology

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  • (PMID = 19481355.001).
  • [ISSN] 1532-2777
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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33. Law YM, Quek ST, Tan PH, Wong SL: Adenoid cystic carcinoma of the breast. Singapore Med J; 2009 Jan;50(1):e8-11
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  • [Title] Adenoid cystic carcinoma of the breast.
  • Adenoid cystic carcinoma of the breast is a rare neoplasm that constitutes less than one percent of all mammary carcinomas.
  • It is a rare variant of adenocarcinoma that usually occurs in the salivary glands.
  • In contrast to the aggressive nature of adenoid cystic carcinoma that occurs in the head and neck region, adenoid cystic carcinoma of the breast has a very favourable prognosis.
  • We describe a 63-year-old woman with adenoid cystic carcinoma detected on mammography in our national breast screening programme, the radiological findings at presentation, the surgical management and a review of the literature.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Mammography. Middle Aged

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  • (PMID = 19224074.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Singapore
  • [Number-of-references] 11
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34. Kim UR, Shah AD, Shanti R, Arora V: Primary adenoid cystic carcinoma of the eyelid. Ophthal Plast Reconstr Surg; 2010 Mar-Apr;26(2):134-6
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  • [Title] Primary adenoid cystic carcinoma of the eyelid.
  • Adenoid cystic carcinoma is a rare epithelial malignancy, which tends to grow slowly.
  • An excisional biopsy with wide margins revealed a diagnosis of primary adenoid cystic carcinoma of eyelid skin with perineural invasion.
  • Although a rare neoplasm, primary adenoid cystic carcinoma of eyelid skin should be included in the differential diagnosis of eyelid tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Eyelid Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 20305522.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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35. Alfaro-Rubio A, Sanmartín Jiménez O, Serra-Guillén C, Requena Caballero C, Hueso Gabriel L, Botella-Estrada R, Nagore Enguídanos E, Llombart Cussac B, Guillén Barona C: [Adenoid cystic carcinoma]. Actas Dermosifiliogr; 2006 Nov;97(9):578-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma].
  • [Transliterated title] Carcinoma adenoide quístico.
  • Adenoid cystic carcinoma is an uncommon tumor of the head and neck.
  • Although it is mainly located in the salivary gland, a skin location has also been described.
  • After resection, the histological diagnosis was adenoid cystic carcinoma.
  • Its histological diagnosis was lymphatic metastasis due to adenoid cystic carcinoma.
  • Primary cutaneous adenoid cystic carcinoma is a very uncommon tumor in which treatment consists in extensive local excision with free margins.
  • Multicenter, prospective studies are necessary to determine the best treatment and especially the adjuvant treatment for adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lip Neoplasms / pathology

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  • (PMID = 17173761.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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36. Liu TR, Chen FJ, Yang AK, Li QL, Guo ZM, Zhang Q, Zeng ZY: [Clinical study of 36 cases with adenoid cystic carcinoma of the maxillary sinus]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Jan;43(1):37-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical study of 36 cases with adenoid cystic carcinoma of the maxillary sinus].
  • OBJECTIVE: To study the clinical characters, management and the prognosis of patients with adenoid cystic carcinoma of the maxillary sinus.
  • METHODS: The clinical data were analyzed retrospectively for 36 patients with adenoid cystic carcinoma of the maxillary sinus to evaluate the treatment results of different modalities.
  • CONCLUSIONS: Advanced adenoid cystic carcinoma should be treated by combined surgery and radiotherapy.
  • Stage, treatment approach and short-term therapeutic response are the most important factors affecting the prognosis of the patients with adenoid cystic carcinoma of the maxillary sinus.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Maxillary Sinus Neoplasms / therapy

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  • (PMID = 18357710.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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37. Emanuel P, Wang B, Wu M, Burstein DE: p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Mod Pathol; 2005 May;18(5):645-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma.
  • Morphologic distinction of high-grade adenoid cystic carcinoma from basaloid squamous cell carcinoma can be difficult.
  • Archival, routinely processed slides were subjected to citrate-based antigen retrieval, exposure to anti-p63 monoclonal 4A4, and developed with a streptavidin-biotin kit and diaminobenzidine as chromogen. p63 was detected in 100% of the adenoid cystic carcinomas (n=14) and 100% of basaloid squamous cell carcinomas (n=16).
  • Basaloid squamous cell carcinomas consistently displayed diffuse p63 positivity, with staining of nearly 100% of tumor cells.
  • In contrast, adenoid cystic carcinoma displayed a consistently compartmentalized pattern within tumor nests.
  • (1) selective staining of a single peripheral layer of p63-positive cells surrounding centrally located tumor cells that were p63-negative and (2) tumor nests consisting of multiple contiguous glandular/cribriform-like units of p63-positive cells surrounding or interspersed with p63-negative cells. p63 immunostaining constitutes a specific and accurate means of distinguishing adenoid cystic carcinoma from basaloid squamous cell carcinoma. p63 positivity in adenoid cystic carcinoma appears to be homologous to that seen in the basal and/or myoepithelial compartments of salivary gland and other epithelia, and may signify a stem-cell-like role for these peripheral cells.
  • Diffuse p63 positivity in basaloid squamous cell carcinoma suggests dysregulation of p63-positive stem cells in poorly differentiated squamous carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Phosphoproteins / analysis. Trans-Activators / analysis
  • [MeSH-minor] DNA-Binding Proteins. Diagnosis, Differential. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 15529180.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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38. You JQ, Wang P: [Protein expression of p53, bcl-2, and bax in adenoid cystic carcinoma of lacrimal gland]. Zhonghua Yi Xue Za Zhi; 2008 Jul 22;88(28):1978-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Protein expression of p53, bcl-2, and bax in adenoid cystic carcinoma of lacrimal gland].
  • OBJECTIVE: To investigate the expression of p53, bcl-2, and hax, apoptosis regulating genes, in adenoid cystic carcinoma of larcrimal gland and the roles thereof in clinical prognosis.
  • METHODS: 56 patients of adenoid cystic carcinoma of larcrimal gland were divided into two groups according to the prognosis: poor prognosis group with recurrence or metastasis within 5 years (n=32) and better prognosis group (n=24) surviving tumor free within 5 years.
  • (1) The overall positive rate of p53 of the patients with adenoid cystic carcinoma of larcrimal gland was 73.2%, significantly higher than that of the normal controls (0, P < 0.05).
  • The protein expression of p53 in adenoid cystic carcinoma of larcrimal gland was negatively correlated with clinical prognosis. (2) The overall expression rate of bcl-2 of the patients with adenoid cystic carcinoma of larcrimal gland was 69.6%, significantly lower than that of the control group (P < 0.05).
  • The expression bcl-2 protein was correlated with better clinical prognosis. (3) The bax positive rate of the patients with adenoid cystic carcinoma of larcrimal gland group was 60.7%, not significantly lower than the control group.
  • CONCLUSION: Some apoptosis regulating genes, such as mutation-type (mt) p53 play an important role in the gene ration and development of adenoid cystic carcinoma of larcrimal gland. p53, bax, and bcl-2 proteins may act as valuable signals for clinical prognosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Lacrimal Apparatus / metabolism. Proto-Oncogene Proteins c-bcl-2 / biosynthesis. Tumor Suppressor Protein p53 / biosynthesis. bcl-2-Associated X Protein / biosynthesis

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  • (PMID = 19062739.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein
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39. Lai FY, Zhang Q, Wu QL, Qing J, Cao Y: [Expression and significance of E-cadherin in adenoid cystic carcinoma of the salivary glands]. Ai Zheng; 2007 Sep;26(9):1025-8
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  • [Title] [Expression and significance of E-cadherin in adenoid cystic carcinoma of the salivary glands].
  • This study was to explore the expression of E-cadherin in adenoid cystic carcinoma of the salivary glands and its correlations to nerve invasion, regional recurrence, distant metastasis and prognosis of this disease.
  • METHODS: The expression of E-cadherin in 55 specimens of adenoid cystic carcinoma of the salivary glands and 20 specimens of normal salivary gland tissue was detected by immunohistochemistry.
  • The positive rate of E-cadherin was significantly higher in normal salivary gland tissues than in adenoid cystic carcinoma tissues (90.0% vs.63.6%, P<0.05).
  • CONCLUSION: E-cadherin expression is down-regulated in adenoid cystic carcinoma of the salivary glands, which is correlated to nerve invasion, regional recurrence and distant metastasis.
  • [MeSH-major] Cadherins / metabolism. Carcinoma, Adenoid Cystic / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17927866.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cadherins
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40. Esmaeli B, Golio D, Kies M, DeMonte F: Surgical management of locally advanced adenoid cystic carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg; 2006 Sep-Oct;22(5):366-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of locally advanced adenoid cystic carcinoma of the lacrimal gland.
  • PURPOSE: To review our experience with multidisciplinary surgical management of locally advanced adenoid cystic carcinoma of the lacrimal gland.
  • METHODS: We present a case series of 7 patients with lacrimal gland adenoid cystic carcinoma treated at our institution between June 2001 and October 2003.
  • RESULTS: The study included 3 men and 4 women (mean age at diagnosis, 44 years).
  • Six patients underwent reconstruction of the socket through the use of a vascularized flap.
  • Five patients had development of distant metastases and died of disease, at follow-up times from 12 to 32 months after surgery.
  • Two patients are alive without evidence of disease, both at 24 months' follow-up.
  • CONCLUSIONS: Orbitectomy with bone removal may be indicated for achieving local and regional control in advanced cases of adenoid cystic carcinoma of the lacrimal gland.
  • The cases in our series highlight the locally invasive and metastatic behavior of this cancer.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Eye Neoplasms / surgery. Lacrimal Apparatus. Orbit Evisceration / methods

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  • (PMID = 16985421.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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41. Nasu K, Kawano Y, Takai N, Kashima K, Miyakawa I: Adenoid cystic carcinoma of Bartholin's Gland. Case report with review of the literature. Gynecol Obstet Invest; 2005;59(1):54-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of Bartholin's Gland. Case report with review of the literature.
  • Adenoid cystic carcinoma of Bartholin's gland is characterized by slow growth, local invasion, and sometimes distant metastasis.
  • We report herein a rare case of stage II adenoid cystic carcinoma of Bartholin's gland that was successfully treated by wide local excision of the tumor and ipsilateral inguinal and pelvic lymphadenectomy.
  • Pathological examination of subsequent excisional biopsy revealed adenoid cystic carcinoma originating in the Bartholin's gland.
  • The patient was diagnosed as having stage II vulvar cancer according to the International Federation of Gynecologists and Obstetricians classification (1988).
  • Adenoid cystic carcinoma of Bartholin's cyst at early stage can be treated by wide local excision as a primary surgery.
  • [MeSH-major] Bartholin's Glands. Carcinoma, Adenoid Cystic / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Diabetes Mellitus, Type 2. Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 15479983.001).
  • [ISSN] 0378-7346
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 20
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42. Elhassani LK, Mrabti H, Ismaili N, Bensouda Y, Masbah O, Bekkouch I, Hassouni K, Kettani F, Errihani H: Advanced adenoid cystic carcinoma of the cervix: a case report and review of the literature. Cases J; 2009;2:6634

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Advanced adenoid cystic carcinoma of the cervix: a case report and review of the literature.
  • INTRODUCTION: Adenoid cystic carcinoma is a malignant epithelial neoplasm derived from the salivary glands.
  • Primary adenoid cystic carcinoma of the cervix is extremely rare, accounting for less than 1% of all cervical carcinomas.
  • In this paper we report a case of primary adenoid cystic carcinoma and a review of the related literature.
  • CASE PRESENTATION: A 68 year-old woman was admitted with signs and symptoms suggestive of a cervical cancer.
  • The radiological and pathological investigations confirmed the diagnostic of primary adenoid cystic carcinoma of the cervix at Stage IIIB according to the International Federation of Gynaecology and Obstetrics classification.
  • CONCLUSION: The optimal management of adenoid cystic carcinoma cannot be established for certain.
  • Concurrent chemo-radiotherapy appears to be a logical option for locally advanced disease.

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  • (PMID = 19829837.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740204
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43. Hara H, Oyama T, Suda K: New criterial for cytologic diagnosis of adenoid cystic carcinoma. Acta Cytol; 2005 Jan-Feb;49(1):43-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New criterial for cytologic diagnosis of adenoid cystic carcinoma.
  • OBJECTIVE: To formulate new criteria for adenoid cystic carcinoma (ADCC).
  • STUDY DESIGN: The usefulness of 17 items for a cytologically definitive diagnosis of ADCC was examined.
  • The frequency (- - +++) of the 17 items in 18 cases of ADCC and 10 non-ADCC cases (pleomorphic adenoma, basal cell adenoma, myoepithelioma and epithelial-myoepithelial carcinoma) that displayed mimicking cytology was examined cytologically.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenoma / diagnosis. Adenoma / pathology. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Myoepithelioma / diagnosis. Myoepithelioma / pathology. Staining and Labeling

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  • (PMID = 15717754.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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44. Vila L, Liu H, Al-Quran SZ, Coco DP, Dong HJ, Liu C: Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland. Mod Pathol; 2009 Oct;22(10):1296-302
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.
  • The CD117 (KIT) protein is overexpressed in many human neoplasms including adenoid cystic carcinoma of salivary glands.
  • To evaluate the function of c-kit-activating mutations in adenoid cystic carcinoma of the salivary gland, we studied 14 cases (13 primary, 1 cervical lymph node metastasis) from our institution.
  • Mutational analyses of c-kit extracellular (exon 9), juxtamembrane (exon 11) and tyrosine kinase domains (exons 13 and 17) were performed by polymerase chain reaction, clonal selection and DNA sequencing.
  • This study is the first to report c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.
  • Identification of such potential gain-of-function mutations in exon 11, and less frequently in exons 9, 13 and 17, suggests that KIT may be involved in the pathogenesis of adenoid cystic carcinoma of salivary glands.
  • Our study raises a prospect of correlation of c-kit mutation and a potential treatment of adenoid cystic carcinoma with tyrosine kinase inhibitor (imatinib).

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  • (PMID = 19617878.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK002958; United States / NIDDK NIH HHS / DK / DK02958
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Other-IDs] NLM/ NIHMS490200; NLM/ PMC3746033
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45. Njeze GE: Adenoid cystic carcinoma of the breast at Enugu Nigeria. Niger J Clin Pract; 2007 Mar;10(1):70-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the breast at Enugu Nigeria.
  • BACKGROUND: (Adenoid cystic carcinoma (ACC) of the breast is a rare type of neoplasm that is histologically indistinguishable from other examples in other sites and generally has a good prognosis).
  • PATIENTS AND METHODS: Case notes of breast cancer patients stored in the medical records department were retrospectively reviewed with a view to studying those with ACC.
  • RESULT: Adenoid cystic carcinoma of the breast was diagnosed in 9 out of 222 patients treated for cancer of the breast, from 1995-2000.
  • Patients aged 34-70 years were afflicted with this disease.
  • A lump in the breast led to the initial suspicion of a tumor.
  • Many of the patients came with advanced disease.
  • CONCLUSION: The disease is rare at Enugu but contrary to findings elsewhere, majority of our patients had advanced disease.
  • Those with early disease appeared to have a good outcome.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Treatment Outcome

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  • (PMID = 17668719.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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46. Koyfman SA, Abidi A, Ravichandran P, Higgins SA, Azodi M: Adenoid cystic carcinoma of the cervix. Gynecol Oncol; 2005 Nov;99(2):477-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the cervix.
  • BACKGROUND: Adenoid cystic carcinoma of the cervix is a rare and aggressive neoplasm for which there are no standardized treatment protocols.
  • CASE: A 38-year-old G3P3 Asian female diagnosed with a stage Ib adenoid cystic carcinoma of the cervix with intermediate risk histologic features received a type III hysterectomy in July 2004.
  • She has been closely followed and has no evidence of disease to date.
  • CONCLUSION: Patients with stage Ib adenoid cystic carcinoma of the cervix, especially those with histologic features associated with a higher risk of recurrence, should receive aggressive local therapy, following the guidelines established for similarly staged patients with squamous cell carcinoma of the cervix.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / therapy. Uterine Cervical Neoplasms / pathology. Uterine Cervical Neoplasms / therapy

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  • (PMID = 16139349.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Shahabi S, Nathan LM, Chanana C, Garett W, Zheng W, Rutherford TJ: Liver metastasis in a case of adenoid cystic carcinoma of the Bartholin's gland: a rare presentation. Arch Gynecol Obstet; 2009 May;279(5):747-50
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  • [Title] Liver metastasis in a case of adenoid cystic carcinoma of the Bartholin's gland: a rare presentation.
  • INTRODUCTION: Adenoid cystic carcinoma of the Bartholin's gland accounts for a minority of all Bartholin's gland malignancies.
  • CASE REPORT: We present the first reported case of Adenoid cystic carcinoma of the Bartholin's gland with metastasis to the liver.
  • DISCUSSION: There is no consensus on the treatment of adenoid cystic carcinoma of the Bartholin's gland.
  • Wide local excision and/or vulvectomy and radiotherapy are advocated for treatment of this cancer.
  • [MeSH-major] Bartholin's Glands / pathology. Carcinoma, Adenoid Cystic / secondary. Liver Neoplasms / secondary. Vulvar Neoplasms / pathology

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  • [ErratumIn] Arch Gynecol Obstet. 2009 May;279(5):751
  • (PMID = 18800221.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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48. Zvrko E, Golubović M: Laryngeal adenoid cystic carcinoma. Acta Otorhinolaryngol Ital; 2009 Oct;29(5):279-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laryngeal adenoid cystic carcinoma.
  • Adenoid cystic carcinomas are malignant tumours and occur in the major and the minor salivary glands.
  • Laryngeal adenoid cystic carcinomas are rare and account for less than 1% of all malignant tumours in the larynx.
  • Adenoid cystic carcinoma is characterised by slow progression, multiple recurrences and late distant metastasis.
  • The aetiology of adenoid cystic carcinoma remains unknown.
  • In this article, the case of laryngeal adenoid cystic carcinoma is described in a 55-year-old male patient who presented with a 3-month history of prelaryngeal pain.
  • For patients with laryngeal adenoid cystic carcinomas, regular and long-term follow-up is mandatory, in order to detect relapses and metastases.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery

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  • [Cites] J Laryngol Otol. 2001 May;115(5):388-92 [11410131.001]
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  • (PMID = 20162031.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2821129
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Laryngectomy / Larynx / Malignant tumours
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49. Till BG, Martins RG: Response to paclitaxel in adenoid cystic carcinoma of the salivary glands. Head Neck; 2008 Jun;30(6):810-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Response to paclitaxel in adenoid cystic carcinoma of the salivary glands.
  • BACKGROUND: Paclitaxel is not considered to be an active drug in adenoid cystic carcinoma (ACC) of the salivary glands.
  • (1) a 58-year-old man with recurrent ACC who developed pulmonary metastases, had progressive disease after a good response to first-line chemotherapy, and then achieved a partial response to weekly single- agent paclitaxel; and (2) a 46-year-old woman with extensive thoracic ACC metastases who achieved a significant response after 2 cycles of paclitaxel chemotherapy.
  • RESULTS: The first patient died of progressive disease approximately 4 months after completing paclitaxel therapy, and the second patient had disease control after 6 cycles of paclitaxel.
  • CONCLUSIONS: Systemic weekly paclitaxel produced a significant response in 2 patients with ACC of the head and neck, and its use in this disease merits further study.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Lung Neoplasms / drug therapy. Paclitaxel / therapeutic use. Salivary Gland Neoplasms / drug therapy
  • [MeSH-minor] Disease-Free Survival. Female. Humans. Male. Middle Aged

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  • (PMID = 17979110.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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50. Rhee CS, Won TB, Lee CH, Min YG, Sung MW, Kim KH, Shim WS, Kim YM, Kim JW: Adenoid cystic carcinoma of the sinonasal tract: treatment results. Laryngoscope; 2006 Jun;116(6):982-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the sinonasal tract: treatment results.
  • Although adenoid cystic carcinoma (ACC) is the second most common cancer occurring in the sinonasal tract, only few studies have been reported.
  • Seventy-one percent of the patients had advanced disease (T3, T4) at the time of diagnosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Nasopharyngeal Neoplasms / therapy. Nose Neoplasms / therapy. Paranasal Sinus Neoplasms / therapy

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  • (PMID = 16735899.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Giannini PJ, Shetty KV, Horan SL, Reid WD, Litchmore LL: Adenoid cystic carcinoma of the buccal vestibule: A case report and review of the literature. Oral Oncol; 2006 Nov;42(10):1029-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the buccal vestibule: A case report and review of the literature.
  • Adenoid cystic carcinoma is the fifth most common salivary gland malignancy following mucoepidermoid carcinoma, adenocarcinoma not otherwise specified (NOS), acinic cell adenocarcinoma and polymorphous low-grade adenocarcinoma (PLGA).
  • Greater than half of adenoid cystic carcinomas occur in the parotid and submandibular glands.
  • Adenoid cystic carcinoma tends to have a protracted clinical course with wide infiltration and late distant metastases.
  • We present a case of an adenoid cystic carcinoma of the buccal vestibule in a 59-year-old Caucasian female patient that she had been aware of for 15 years.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Mouth Neoplasms / pathology. Salivary Gland Neoplasms / pathology


52. Dong F, Gidley PW, Ho T, Luna MA, Ginsberg LE, Sturgis EM: Adenoid cystic carcinoma of the external auditory canal. Laryngoscope; 2008 Sep;118(9):1591-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the external auditory canal.
  • OBJECTIVE/HYPOTHESIS: To describe the clinical history and outcome of patients with adenoid cystic carcinoma (ACC) of the external auditory canal (EAC).
  • RESULTS: The mean age at diagnosis was 42 years (median, 38.5 years), and the most common presenting complaints were otalgia and ear canal mass.
  • Nine patients (41%) developed recurrences at a mean of 8 years (median, 8 years) after initial diagnosis, six died of ACC, and three were living with distant metastases at their last follow-up.
  • The mean duration of symptoms at the time of diagnosis was 7.7 years (range, 2-30 years) for patients who developed a recurrence after treatment vs. 1.2 year (range, 0-2 years) for patients who remained disease-free (P = .137).
  • Every patient who had recurrent disease reported a duration of symptoms of >or=2 years (P = .013), and every patient with a duration of symptoms >2 years recurred (P = .002).
  • In addition to successful local therapy, early diagnosis may be the only other effective means of preventing distant metastases.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Ear Canal. Ear Neoplasms / diagnosis

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  • (PMID = 18677277.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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53. Delbouck C, Roper N, Aubert C, Souchay C, Choufani G, Hassid S: Unusual presentation of adenoid cystic carcinoma of the maxillary antrum. B-ENT; 2009;5(4):265-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual presentation of adenoid cystic carcinoma of the maxillary antrum.
  • Unusual presentation of adenoid cystic carcinoma of the maxillary antrum.
  • Adenoid cystic carcinoma (ACC) is a rare tumour which affects mainly the major and accessory salivary glands.
  • Based on a well-illustrated case of extensive maxillary ACC involving the palate, orbit floor, and pterygo-palatine fossa, we discuss the prognosis and the importance of an early diagnosis of ACC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / therapy. Maxillary Sinus. Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinus Neoplasms / therapy

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  • (PMID = 20163054.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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54. Woida FM, Ribeiro-Silva A: Adenoid cystic carcinoma of the Bartholin gland: an overview. Arch Pathol Lab Med; 2007 May;131(5):796-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the Bartholin gland: an overview.
  • Vulvar carcinoma is the fourth most frequently encountered malignancy of the female reproductive tract.
  • Primary adenoid cystic carcinoma of the Bartholin gland is very rare.
  • Immunohistochemically, the tumor cells express low-molecular-weight keratins, carcinoembryonic antigen, lysozyme, alpha1-antichymotrypsin, S100, and type IV collagen.
  • Adenoid cystic carcinoma of the Bartholin gland is a slow-growing but locally very aggressive neoplasm with high capacity for recurrence.
  • [MeSH-major] Bartholin's Glands / pathology. Carcinoma, Adenoid Cystic / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 17488169.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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55. Haddad RI, Posner MR, Busse PM, Norris CM Jr, Goguen LA, Wirth LJ, Blinder R, Krane JF, Tishler RB: Chemoradiotherapy for adenoid cystic carcinoma: preliminary results of an organ sparing approach. Am J Clin Oncol; 2006 Apr;29(2):153-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemoradiotherapy for adenoid cystic carcinoma: preliminary results of an organ sparing approach.
  • OBJECTIVES: A retrospective review of primary chemoradiotherapy (CRT) for adenoid cystic carcinoma (ACC) was performed to determine if CRT might be considered as an alternative to radiotherapy and/or definitive surgery.
  • METHODS: All treatment-naive patients with ACC of the head and neck who were treated with definitive primary chemoradiotherapy using carboplatinum and paclitaxel at Dana-Farber Cancer Institute in 2000 through 2004 were identified.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / radiotherapy. Head and Neck Neoplasms / drug therapy. Head and Neck Neoplasms / radiotherapy

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  • (PMID = 16601434.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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56. Luna-Ortiz K, Carmona-Luna T, Cano-Valdez AM, Mosqueda-Taylor A, Herrera-Gómez A, Villavicencio-Valencia V: Adenoid cystic carcinoma of the tongue--clinicopathological study and survival analysis. Head Neck Oncol; 2009;1:15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the tongue--clinicopathological study and survival analysis.
  • BACKGROUND: To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival.
  • METHODS: Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC.
  • Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years.
  • CONCLUSION: ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion.
  • As the role of c-kit could not be assessed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised.
  • Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Tongue Neoplasms / pathology

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  • (PMID = 19480697.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Other-IDs] NLM/ PMC2694803
  • [General-notes] NLM/ Original DateCompleted: 20100629
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57. Zhang Q, Yang L, Yang AK, Guo ZM: [Clinical study on 88 cases of adenoid cystic carcinoma in nasal cavity and paranasal sinuses]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Apr;44(4):311-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical study on 88 cases of adenoid cystic carcinoma in nasal cavity and paranasal sinuses].
  • OBJECTIVE: To study the clinical characters, diagnosis, management and prognosis of patients with adenoid cystic carcinoma in nasal cavity and paranasal sinuses.
  • METHODS: The data were analyzed retrospectively for 88 patients with adenoid cystic carcinoma in nasal cavity and paranasal sinuses, to evaluate the clinical characters, diagnostic and therapeutical aspects and the contribution of every factor influencing the survival.
  • CONCLUSIONS: Advanced adenoid cystic carcinoma should be treated by combined surgical operation and radiotherapy.
  • Stage and treatment approach are the independent factors affecting the prognoses of patients with adenoid cystic carcinoma in nasal cavity and paranasal sinuses.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Nose Neoplasms. Paranasal Sinus Neoplasms

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  • (PMID = 19558839.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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58. Shang J, Sheng L, Wang K, Shui Y, Wei Q: Expression of neural cell adhesion molecule in salivary adenoid cystic carcinoma and its correlation with perineural invasion. Oncol Rep; 2007 Dec;18(6):1413-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of neural cell adhesion molecule in salivary adenoid cystic carcinoma and its correlation with perineural invasion.
  • The expression of neural cell adhesion molecule (NCAM) was analyzed in immunohistochemical preparations from adenoid cystic carcinoma.
  • The goal was to evaluate whether NCAM expression could be used as a biological marker for the perineural invasion of adenoid cystic carcinoma in the head and neck.
  • A high incidence of perineural invasion was found in adenoid cystic carcinoma in the parotid, hard palate, maxillary sinus and oral cavity.
  • All 6 cases displayed positive NCAM staining, and 5 displayed perineural invasion in the primary adenoid cystic carcinoma.
  • In conclusion, NCAM expression can, to a certain extent, be used as a predictor of perineural invasion in adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / metabolism. Gene Expression Regulation, Neoplastic. Neural Cell Adhesion Molecules / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17982624.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Neural Cell Adhesion Molecules
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59. Mastropasqua MG, Maiorano E, Pruneri G, Orvieto E, Mazzarol G, Vento AR, Viale G: Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast. Mod Pathol; 2005 Oct;18(10):1277-82
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  • [Title] Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast.
  • Adenoid cystic carcinoma of the breast represents a unique clinicopathologic entity with a variable histological appearance and a relatively indolent clinical course in most of the cases.
  • Adenoid cystic carcinoma may be difficult to differentiate from infiltrating duct carcinomas, and in particular from tubular and cribriform carcinomas, especially in core or vacuum-assisted biopsies.
  • We evaluated the prevalence of c-kit, p63, and e-cadherin immunoreactivity in a series of 20 adenoid cystic carcinomas, comparing the results with those obtained in a series of infiltrating tubular carcinomas and infiltrating cribriform carcinomas.
  • Three (15%) adenoid cystic carcinomas and all infiltrating tubular and cribriform carcinomas showed estrogen receptor and/or progesterone receptor immunoreactivity (P < 0.00001 for estrogen and P = 0.00002 for progesterone receptors).
  • Adenoid cystic carcinomas consistently lacked any immunoreactivity for HER/2, whereas three (15%) infiltrating and cribriform carcinomas showed weak and incomplete membrane staining (P = 0.23077).
  • Membranous immunoreactivity for c-kit was found in all except one (predominantly basaloid) adenoid cystic carcinomas (95%), and in none of the infiltrating tubular and cribriform carcinomas (P < 0.00001).
  • Nuclear immunoreactivity for p63 was found in all except three (predominantly basaloid) adenoid cystic carcinomas (85%) and in none of the infiltrating tubular and cribriform carcinomas (P < 0.00001).
  • All infiltrating tubular and cribriform carcinomas and 18/20 (90%) adenoid cystic carcinomas showed immunoreactivity for e-cadherin (P = 0.48718).
  • In summary, adenoid cystic carcinomas showed the following phenotype: estrogen receptor-/progesterone receptor-/c-kit+/p63+ (13 cases, 65%), estrogen receptor-/progesterone receptor/c-kit+/p63- (three cases, 15%), estrogen receptor-/progesterone receptor-/c-kit-/p63+ (one case, 5%), estrogen receptor+/progesterone receptor+/c-kit+/p63+ (two cases, 10%), and estrogen receptor+/progesterone receptor-/c-kit+/p63+ (one case).
  • By contrast, all the infiltrating tubular and cribriform carcinomas showed the estrogen receptor+/progesterone receptor+/c-kit-/p63- phenotype.
  • Our data provide evidence that immunoreactivity for c-kit and/or p63 may be useful in differentiating adenoid cystic carcinomas from other types of breast cancer.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Membrane Proteins / metabolism. Proto-Oncogene Proteins c-kit / metabolism

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  • (PMID = 15846389.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Cadherins; 0 / Membrane Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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60. Soprani F, Armaroli V, Venturini A, Emiliani E, Casolino D: A rare case of adenoid cystic carcinoma of the nasopharynx manifesting as Horner's syndrome: discussion and review of the literature. Acta Otorhinolaryngol Ital; 2007 Aug;27(4):216-9
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  • [Title] A rare case of adenoid cystic carcinoma of the nasopharynx manifesting as Horner's syndrome: discussion and review of the literature.
  • Adenoid cystic carcinoma is a malignant tumour involving the salivary glands, rarely developing in the nasopharynx.
  • The biological behaviour of adenoid cystic carcinoma is characterized by slow growth rate, high tendency to local recurrence and metastatic spread.
  • Initial presentation of nasopharyngeal adenoid cystic carcinoma with paresis of cranial nerves and Horner's syndrome is infrequent.
  • The Authors present a case of a rare adenoid cystic carcinoma of the nasopharynx, at admission with Horner's syndrome, in a 66-year-old male.
  • Definitive histopathological examination revealed an adenoid cystic carcinoma with mixed cribriform and solid pattern.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Horner Syndrome / diagnosis. Nasopharyngeal Neoplasms / pathology. Nasopharyngeal Neoplasms / surgery
  • [MeSH-minor] Aged. Combined Modality Therapy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 17957854.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 36
  • [Other-IDs] NLM/ PMC2640026
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61. Rutherford S, Yu Y, Rumpel CA, Frierson HF Jr, Moskaluk CA: Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinoma. Cancer Lett; 2006 May 18;236(2):309-17
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  • [Title] Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinoma.
  • As genomic deletion in chromosome 6 has been implicated in the pathogenesis of adenoid cystic carcinoma (ACC), we assayed 58 paired normal and tumor samples for loss of heterozygosity (LOH) using 38 microsatellite markers spanning chromosome 6.
  • Among the heterogeneous histologic subtypes of salivary gland carcinomas, only salivary duct carcinoma had a similar frequency of deletion in this region.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Chromosome Deletion. Chromosomes, Human, Pair 6. Genes, Tumor Suppressor. Salivary Ducts / metabolism. Salivary Gland Neoplasms / genetics

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  • (PMID = 16054751.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5K08CA74431; United States / NIDCR NIH HHS / DE / 5R01DE04694
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / PLAGL1 protein, human; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; EC 2.7.1.- / LATS1 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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62. Badakhshi H, Marnitz S, Scherer H, Budach V, Haisch A: [Adenoid cystic carcinoma of the oropharynx. Brachytherapy for the treatment of local recurrences]. HNO; 2008 Mar;56(3):328-31
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  • [Title] [Adenoid cystic carcinoma of the oropharynx. Brachytherapy for the treatment of local recurrences].
  • [Transliterated title] Adenoidzystisches Karzinom des Oropharynx. Brachytherapie zur Behandlung eines lokalen Rezidivs.
  • PURPOSE: Adenoid cystic carcinomas are rare tumours.
  • We report on a safe and effective salvage option in the treatment of adenoid cystic carcinoma.
  • MATERIAL AND METHODS: A 44 year old woman with the diagnosis of adenoid cystic carcinoma of the oropharynx and simultaneous pulmonary metastases received a mixed beam photon radiotherapy and a neutron boost.
  • On the basis of a pretreatment MRI, a single dose of 5 Gy encompassing the palpable tumour was given to a total dose of 15 Gy.
  • CONCLUSION: HDR-Ir brachytherapy is an effective method for the treatment of local recurrences of an adenoid cystic carcinoma, even after preradiotherapy.
  • [MeSH-major] Brachytherapy / methods. Carcinoma, Adenoid Cystic / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Oropharyngeal Neoplasms / radiotherapy

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  • (PMID = 18288466.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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63. Caiado A, Moura e Sá J: [Tracheal tumors review--a clinical case of adenoid cystic carcinoma]. Rev Port Pneumol; 2008 Jul-Aug;14(4):527-34
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  • [Title] [Tracheal tumors review--a clinical case of adenoid cystic carcinoma].
  • [Transliterated title] Revisão dos tumores da traqueia--a propósito de um caso clínico de tumor adenóide cístico.
  • Their incidence is less than 0.2 per 100 000 inhabitants and 180 times less frequent than lung cancer.
  • The authors report a case of adenoid cystic carcinoma in a 23 year-old woman, non-smoker, with acute clinical inspiratory stridor, where Nd-Yag laser use was extremely important to tracheal permeability as the tumor occupied over 80% of the tracheal lumen and could have led to imminent patient asphyxia.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Tracheal Neoplasms

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  • (PMID = 18622529.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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64. Kitada M, Ozawa K, Sato K, Hayashi S, Tokusashi Y, Miyokawa N, Sasajima T: Adenoid cystic carcinoma of the peripheral lung: a case report. World J Surg Oncol; 2010;8:74
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  • [Title] Adenoid cystic carcinoma of the peripheral lung: a case report.
  • Adenoid cystic carcinoma of the peripheral lung is a rare entity.
  • We recently encountered a patient with adenoid cystic carcinoma.
  • The diagnosis was unclear, but lung cancer could not be ruled out.
  • Thoracoscopic biopsy was performed, and intraoperative pathological diagnosis revealed the carcinoma of the lung.
  • Histopathological examination revealed adenoid cystic carcinoma with a characteristic cribriform structure.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Pneumonectomy / methods. Radiography, Thoracic. Thoracic Surgery, Video-Assisted / methods. Tomography, X-Ray Computed

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  • (PMID = 20796281.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2936894
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65. Fayyad LM, Al-Jader KM, Al-Hawwari BA: Asynchronous adenoid cystic carcinoma of the prostate and transitional cell carcinoma of the urinary bladder. Saudi Med J; 2006 Jul;27(7):1060-2
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  • [Title] Asynchronous adenoid cystic carcinoma of the prostate and transitional cell carcinoma of the urinary bladder.
  • Histologic variants of prostatic carcinoma are readily recognized.
  • In this report, we describe a rare variant, adenoid cystic carcinoma, in a 75-year-old man previously diagnosed to have transitional cell carcinoma of the urinary bladder.
  • The diagnosis of adenoid cystic carcinoma was made by the characteristic microscopic features of the tumor morphologically and immunohistochemically.
  • Two months later he was found to have metastatic disease.
  • Five and a half months after diagnosis, he died with metastatic disease.
  • Making this case unique is the asynchronous occurrence of this variant with transitional cell carcinoma of the urinary bladder, which has never been reported in the literature.
  • We discussed the histopathologic and immunohistochemical features of adenoid cystic carcinoma of the prostate with review of literature.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Transitional Cell / pathology. Neoplasms, Second Primary / pathology. Prostatic Neoplasms / pathology. Urinary Bladder Neoplasms / pathology


66. Williams MD, Al-Zubidi N, Debnam JM, Shinder R, DeMonte F, Esmaeli B: Bone invasion by adenoid cystic carcinoma of the lacrimal gland: preoperative imaging assessment and surgical considerations. Ophthal Plast Reconstr Surg; 2010 Nov-Dec;26(6):403-8
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  • [Title] Bone invasion by adenoid cystic carcinoma of the lacrimal gland: preoperative imaging assessment and surgical considerations.
  • PURPOSE: To identify the incidence of radiologically and histologically documented bony invasion of the lacrimal gland fossa by adenoid cystic carcinoma.
  • PATIENTS AND METHODS: The authors reviewed the records of all 18 patients with lacrimal gland adenoid cystic carcinoma surgically treated at their institution from 1997 to 2009 for imaging findings (blinded review) and histologic findings on evaluation of the lacrimal gland fossa.
  • American Joint Committee on Cancer tumor stages after preoperative imaging were as follows: T1N0M0, 2 patients; T2N0M0, 5 patients; T3aN0M0, 2 patients; T3bN0M0, 5 patients; T3bN0M1, 2 patients; T4bN0M0, one patient; and TxN0M0, one patient.
  • CONCLUSIONS: Adenoid cystic carcinoma of the lacrimal gland is associated with bone invasion in essentially all but the smallest of tumors (T1).
  • This high rate of bone involvement may warrant addressing the bony walls during surgery for adenoid cystic carcinoma of the lacrimal gland.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Nasal Bone / pathology. Nose Neoplasms / pathology


67. Carrasco Ortiz D, Aldape Barrios B: Adenoid cystic carcinoma of the dorsum of the tongue: presentation of a case. Med Oral Patol Oral Cir Bucal; 2006 Aug;11(5):E417-20
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  • [Title] Adenoid cystic carcinoma of the dorsum of the tongue: presentation of a case.
  • Adenoid cystic carcinoma is the most frequent malignant neoplasm of minor salivary glands (76.5%); it is clinically characterized by slow growth, and its most frequent localization is the hard palate.
  • Histopathologically it presents three patterns, cribriform, tubular and solid; the solid type is related to a poor prognostic contrary to the cribriform type, which has a better prognosis.
  • A 19 year-old man presented a recurrent lesion on the dorsum of the tongue previously diagnosed as monomorphic adenoma.
  • In a second biopsy it was diagnosed as adenoid cystic carcinoma.
  • The following immunohistochemical studies were ordered: CALP, CEA, Epithelial Membrane Antigen, Glial Fibrilar Acid Protein, Ki67; all of these studies were positive and with different intensities, corroborating the diagnosis of adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16878059.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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68. Arshad MH, Khalid U, Ghaffar S: Adenoid cystic carcinoma of the external auditory canal. J Coll Physicians Surg Pak; 2009 Nov;19(11):726-8
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  • [Title] Adenoid cystic carcinoma of the external auditory canal.
  • This is a rare case of a young male with biopsy proven adenoid cystic carcinoma of the external auditory canal who underwent excision of the lesion with superficial parotidectomy sparing the facial nerve.
  • Histopathology showed perineural invasion, which is a diagnostic hallmark of adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Ear Canal. Ear Neoplasms / surgery

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  • (PMID = 19889272.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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69. Lupinetti AD, Roberts DB, Williams MD, Kupferman ME, Rosenthal DI, Demonte F, El-Naggar A, Weber RS, Hanna EY: Sinonasal adenoid cystic carcinoma: the M. D. Anderson Cancer Center experience. Cancer; 2007 Dec 15;110(12):2726-31
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  • [Title] Sinonasal adenoid cystic carcinoma: the M. D. Anderson Cancer Center experience.
  • BACKGROUND: Adenoid cystic carcinoma of the sinonasal tract is a rare cancer that accounts for 10% of all malignancies at this site.
  • The objective of the current study was to evaluate prognostic factors, treatment outcomes, recurrence patterns, and survival rates for sinonasal adenoid cystic carcinoma.
  • Between 1990 and 2004, 105 patients were evaluated for adenoid cystic carcinoma of the sinonasal tract at a single institution.
  • RESULTS: One hundred five patients with adenoid cystic carcinoma were evaluated, including 58 women and 47 men.
  • The majority of patients presented with T3/T4 (76.7%), N0 (98%), M0 (97%) disease.
  • Eighty-four percent of patients underwent surgery and received postoperative radiation as treatment for their primary disease.
  • The 5-year overall survival and disease specific survival rates were 62.9% and 70.9%, respectively.
  • CONCLUSIONS: Adenoid cystic carcinoma of the paranasal sinuses is a rare disease, and the ideal treatment paradigm has yet to be defined.
  • Although local recurrences develop in a significant percentage of patients, survival from this disease exceeds that of other sinonasal malignancies.
  • [MeSH-major] Carcinoma, Adenoid Cystic / therapy. Paranasal Sinus Neoplasms / therapy

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  • [Copyright] 2007 American Cancer Society
  • (PMID = 17960615.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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70. Dincer N, Tezel GG, Sungur A, Himmetoglu C, Huebner K, Güler G: Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland. Oral Oncol; 2010 Mar;46(3):195-9
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  • [Title] Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland.
  • Mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) are salivary gland neoplasms with divergent morphological features and clinical behavior.
  • In previous studies, we have shown concordant loss of Fhit and Wwox expression in breast cancer, with significantly more frequent loss in cancers of basal-like phenotype.
  • Correlations among immunohistochemical markers and histological type were determined by statistical analyses.
  • The results suggest that, as for breast cancer, loss of Fhit and Wwox expression might have a role in the pathogenesis of basaloid differentiation in salivary gland neoplasms; alternatively, differences in chromatin structure at chromosome fragile regions might make fragile genes more accessible to DNA damage and rearrangement early during preneoplastic stages of basaloid cancers.
  • [MeSH-major] Acid Anhydride Hydrolases / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / metabolism. Neoplasm Proteins / metabolism. Oxidoreductases / metabolism. Salivary Gland Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism

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  • [Copyright] (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20060354.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Tumor Suppressor Proteins; 0 / fragile histidine triad protein; EC 1.- / Oxidoreductases; EC 1.1.1.- / WWOX protein, human; EC 3.6.- / Acid Anhydride Hydrolases
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71. Fu ZC, Zhang B, Fu ZJ: As2O3 may be a treatment option for adenoid cystic carcinoma of salivary gland. Med Hypotheses; 2010 Dec;75(6):490-1
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  • [Title] As2O3 may be a treatment option for adenoid cystic carcinoma of salivary gland.
  • Adenoid cystic carcinoma (ACC) is an uncommon tumor of the head and neck that may occur in any salivary gland tissue.
  • It presents a number of challenges related to facial nerve management and disease extension into surrounding soft tissue and bony compartments.
  • It is a high malignant carcinoma characterized by intensive local invasion and insidious distant metastasis to the lung at an early stage, which is responsible for a poor long-term survival rate.
  • The main clinical treatment to adenoid cystic carcinoma depended on surgical operation in the past.
  • However, it was not so easy to completely excise adenoid cystic carcinoma which resulting in the residual of tumor cells.
  • Adenoid cystic carcinoma is not sensitive to conventional chemotherapeutics, so it is necessary to explore a new kind of drug which possesses inhibition and killing effects to this tumor.
  • It also induces apoptosis in a variety of cancer cells over a wide dose range.
  • A(S2)O(3) may become a treatment option for adenoid cystic carcinoma of salivary gland.
  • [MeSH-major] Apoptosis / drug effects. Arsenicals / therapeutic use. Carcinoma, Adenoid Cystic / drug therapy. Growth Inhibitors / therapeutic use. Oxides / therapeutic use. Salivary Gland Neoplasms / drug therapy

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20656411.001).
  • [ISSN] 1532-2777
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arsenicals; 0 / Growth Inhibitors; 0 / Oxides; S7V92P67HO / arsenic trioxide
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72. Pradhan D, Pattnaik K, Pahi J, Mohanty P, Satpathy S, Behuria S: Adenoid cystic carcinoma in the uterine cervix: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):1039-42
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  • [Title] Adenoid cystic carcinoma in the uterine cervix: a case report.
  • BACKGROUND: Adenoid cystic carcinoma, a variant of adenocarcinoma of the uterine cervix, is an extremely rare neoplasm.
  • This report describes a case of primary adenoid cystic carcinoma of the uterine cervix and includes the cytopathologic and histopathologic findings.
  • The diagnosis of adenoid cystic carcinoma was confirmed by the histopathologic examination of the biopsy specimen as well as the excised specimen, which characteristically revealed the presence of a cribriform pattern of the tumor cells.
  • CONCLUSION: We reported a case of a rare and unusual variant of adenocarcinoma of the uterine cervix by considering the characteristic cytologic features of the globules of pale, translucent material surrounded by halos of cells in cribriform adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Cervix Uteri / pathology. Uterine Cervical Neoplasms / pathology

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  • (PMID = 21053595.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Qureshi SS, Nadkarni MS, Shrikhande SV, Desai S, Deodhar K, Ramadwar M, Shukla PJ: Hepatic resection for metastasis from adenoid cystic carcinoma of parotid gland. Indian J Gastroenterol; 2005 Jan-Feb;24(1):29-30
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  • [Title] Hepatic resection for metastasis from adenoid cystic carcinoma of parotid gland.
  • Adenoid cystic carcinoma is the commonest malignant tumor of the submandibular and minor salivary glands; the parotid gland constitutes a small share of this neoplasm.
  • We present a 30-year-old woman with solitary liver metastasis from an adenoid cystic carcinoma of the parotid gland, which had been surgically treated 10 years ago.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Parotid Neoplasms / pathology

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  • (PMID = 15778528.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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74. Haresh KP, Prabhakar R, Rath GK, Sharma DN, Julka PK, Subramani V: Adenoid cystic carcinoma of the trachea treated with PET-CT based intensity modulated radiotherapy. J Thorac Oncol; 2008 Jul;3(7):793-5
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  • [Title] Adenoid cystic carcinoma of the trachea treated with PET-CT based intensity modulated radiotherapy.
  • Adenoid cystic carcinoma, which is of salivary gland origin, account for about one thirds of adult primary tracheal tumors.
  • Computed tomography scan of the thorax at our hospital showed a residual disease in the primary site, size of which was same as that in the preoperative scan.
  • PET-CT done 1 year posttreatment showed no residual disease.
  • Presently he is disease free with good pulmonary reserve.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Positron-Emission Tomography. Radiotherapy, Intensity-Modulated. Tomography, X-Ray Computed. Tracheal Neoplasms / radiotherapy

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  • (PMID = 18594327.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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75. Daa T, Kaku N, Kashima K, Nakayama I, Yokoyama S: Expression of beta-catenin, E-cadherin and cyclin D1 in adenoid cystic carcinoma of the salivary gland. J Exp Clin Cancer Res; 2005 Mar;24(1):83-7
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  • [Title] Expression of beta-catenin, E-cadherin and cyclin D1 in adenoid cystic carcinoma of the salivary gland.
  • We evaluated the expression of beta-catenin, E-cadherin, and cyclin-D1 in 23 cases of adenoid cystic carcinoma (ACC) of the salivary gland.
  • [MeSH-major] Cadherins / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Cyclin D1 / metabolism. Cytoskeletal Proteins / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / pathology. Trans-Activators / metabolism


76. Pandya AN, Shah P, Patel R, Patel PR: Adenoid cystic carcinoma of breast and the importance of differentiation from collagenous spherulosis by FNAC. J Cytol; 2010 Apr;27(2):69-70

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  • [Title] Adenoid cystic carcinoma of breast and the importance of differentiation from collagenous spherulosis by FNAC.
  • We are presenting a case of adenoid cystic carcinoma (ACC) of breast in a 66-year-old woman having lump in left breast, admitted to surgical ward of our institute.
  • A diagnosis of ACC of breast was made and subsequently confirmed histopathologically and on immunohistochemistry.

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  • (PMID = 21157554.001).
  • [ISSN] 0974-5165
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3001180
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / FNAC / breast, collagenous spherulosis
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77. Visa L, Caballero M, Grau JJ: [Response to metronomic chemotherapy in a metastatic adenoid cystic carcinoma of the parotid gland]. Acta Otorrinolaringol Esp; 2010 Nov-Dec;61(6):452-4
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  • [Title] [Response to metronomic chemotherapy in a metastatic adenoid cystic carcinoma of the parotid gland].
  • [Transliterated title] Respuesta a quimioterapia metronómica en un carcinoma adenoide quístico metastásico de parótida.
  • Formerly, salivary gland cancer was considered to be chemoresistant.
  • Chemotherapy is indicated when distant metastases or inoperable locorregional disease are observed, although the chemotherapy schedule is not well defined.
  • Data on chemotherapy treatment for adenoid cystic carcinoma consist of phase II trials.
  • Our case report shows for first time the clinical activity of low-dose paclitaxel and cisplatin chemotherapy given separately as a single agent in metastatic adenoid cystic carcinoma of the parotid.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / secondary. Cisplatin / administration & dosage. Paclitaxel / administration & dosage. Parotid Neoplasms / drug therapy. Parotid Neoplasms / pathology

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  • [Copyright] Copyright © 2009 Elsevier España, S.L. All rights reserved.
  • (PMID = 20152955.001).
  • [ISSN] 1988-3013
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antineoplastic Agents; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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78. Sbitti Y, Kadiri H, Fetohi M, Elghissassi I, M'rabti H, Boutayeb S, Ichou M, Boussen H, Errihani H: [Primary adenoid cystic carcinoma in breast]. Cancer Radiother; 2009 Jan;13(1):65-8
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  • [Title] [Primary adenoid cystic carcinoma in breast].
  • [Transliterated title] Carcinome adénoïde kystique primitif du sein.
  • Adenoid cystic carcinoma (ACC) of the breast is a rare neoplasm.
  • Diagnosis was based on final histopathological exam completed by immunohistochemistry or after slides review.
  • [MeSH-major] Breast Neoplasms. Carcinoma, Adenoid Cystic

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  • (PMID = 19097926.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 18
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79. Xia H, Li LJ, Han B, Pan J, Gao N: [Research on the differently expressed homeobox genes related to adenoid cystic carcinoma]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2010 Apr;28(2):190-4
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  • [Title] [Research on the differently expressed homeobox genes related to adenoid cystic carcinoma].
  • OBJECTIVE: To investigate the differently expressed Homeobox genes between adenoid cystic carcinoma of salivary gland and normal gland tissue, and find out the effect of homeobox genes on oncogenesis and differentiation of adenoid cystic carcinoma of salivary gland.
  • METHODS: Six strictly paired specimens including adenoid cystic carcinoma and its surrounding normal gland tissue and two pairs of specimens including cell strain of adenoid cystic carcinoma and its surrounding normal gland tissue were established.
  • RT-PCR technique was used to examine the mRNA expressing level of highly suspected relevant genes of adenoid cystic carcinoma in different specimens.
  • CONCLUSION: As the key gene to cellular proliferation and differentiation, homeobox genes are closely relevant to the oncogenesis of adenoid cystic carcinoma of salivary gland.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Salivary Gland Neoplasms

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  • (PMID = 20480666.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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80. Beltran D, Faquin WC, Gallagher G, August M: Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma. J Oral Maxillofac Surg; 2006 Mar;64(3):415-23
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  • [Title] Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma.
  • PURPOSE: Polymorphous low-grade adenocarcinoma (PLGA) is a salivary gland malignancy characterized by indolent growth and a low rate of metastasis.
  • PLGA shares histological features with adenoid cystic carcinoma (ACC), including infiltrating solid and cribriform patterns, presence of cystic spaces, and neurotropism.
  • This study examines the potential use of c-kit, Ki-67, smooth muscle actin (SMA), and muscle-specific actin (MSA) as ancillary markers for distinguishing PLGA from ACC.
  • RESULTS: PLGA showed a significantly weaker immunohistochemical expression of c-kit compared with ACC (P = < .001).
  • CONCLUSIONS: Statistically significant immunohistochemical staining patterns using c-kit and SMA in this study support their potential use as markers to differentiate PLGA from ACC in cases where the diagnosis can be challenging.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. Salivary Gland Neoplasms / chemistry. Salivary Gland Neoplasms / classification
  • [MeSH-minor] Actins / analysis. Adult. Aged. Aged, 80 and over. Cytoskeletal Proteins / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Muscle Proteins / analysis. Neoplasm Proteins / analysis. Proto-Oncogene Proteins c-kit / analysis. Statistics, Nonparametric

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  • (PMID = 16487803.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Ki-67 Antigen; 0 / Muscle Proteins; 0 / Neoplasm Proteins; 0 / Smooth muscle protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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81. Pino Rivero V, Pantoja Hernández CG, González Palomino A, Pardo Romero G, Trinidad Ramos G, Blasco Huelva A: [Adenoid cystic carcinoma of tongue. Report of a case and literature review]. An Otorrinolaringol Ibero Am; 2006;33(5):449-54
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  • [Title] [Adenoid cystic carcinoma of tongue. Report of a case and literature review].
  • [Transliterated title] Carcinoma adenoide quístico de lengua. A propósito de un caso y revisión de la literatura.
  • We report the clinical case of an adenoid cystic carcinoma on the base of the tongue, a rare malignant tumor of slow-growing but aggressive with a propepnsity for perineural invasion.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Tongue Neoplasms / diagnosis

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  • (PMID = 17091857.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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82. Albores-Saavedra J, Heard SC, McLaren B, Kamino H, Witkiewicz AK: Cylindroma (dermal analog tumor) of the breast: a comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast. Am J Clin Pathol; 2005 Jun;123(6):866-73
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  • [Title] Cylindroma (dermal analog tumor) of the breast: a comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast.
  • We compared 4 breast cylindromas with 50 dermal cylindromas and 8 adenoid cystic breast carcinomas.
  • Except for a modest increase in the number of eccrine ducts and reactive Langerhans cells in dermal cylindromas, breast and dermal cylindromas showed identical histologic and immunohistochemical features.
  • Clusters of sebaceous cells and a few eccrine ducts are described in breast cylindromas.
  • Cytokeratin 7 labeled predominantly the central basaloid cells, and smooth muscle actin stained peripheral myoepithelial cells in breast and dermal cylindromas.
  • Cylindromas of the breast and skin did not express cytokeratin 20, gross cystic disease fluid protein 15, or estrogen or progesterone receptor.
  • Breast cylindroma might be confused with the solid variant of adenoid cystic carcinoma, especially in needle core biopsy specimens, because they share nodular and trabecular patterns, basaloid cells, myoepithelial cells, eccrine ducts, and hyaline globules of basement membrane material.
  • However, adenoid cystic carcinoma displays an infiltrative growth pattern, cytologic atypia, and mitotic figures and lacks the continuous, thickened basement membrane.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Sweat Glands / pathology

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  • (PMID = 15899777.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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83. Glazebrook KN, Reynolds C, Smith RL, Gimenez EI, Boughey JC: Adenoid cystic carcinoma of the breast. AJR Am J Roentgenol; 2010 May;194(5):1391-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the breast.
  • OBJECTIVE: The purpose of our study was to describe the imaging findings in adenoid cystic carcinoma (ACC) of the breast, with pathologic and clinical correlation.
  • CONCLUSION: Recognition of ACC is important to avoid delay in diagnosis because this tumor has a good prognosis with rare metastases to axillary lymph nodes.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / epidemiology. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / epidemiology. Magnetic Resonance Imaging / methods. Mammography / methods


84. Shamim T, Varghese VI, Shameena PM, Sudha S: Primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis: a case report. J Oral Sci; 2008 Mar;50(1):95-8
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  • [Title] Primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis: a case report.
  • Intraosseous adenoid cystic carcinoma is an extremely rare neoplasm with only 17 cases reported previously.
  • A case of primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis in a 45-year-old man is reported, together with a brief review of the literature.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology. Solitary Pulmonary Nodule / secondary
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 18403891.001).
  • [ISSN] 1343-4934
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 10
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85. Chuah KL, Lim KH, Koh MS, Tan HW, Yap WM: Diagnosis of adenoid cystic carcinoma of the lung by bronchial brushing: a case report. Acta Cytol; 2007 Jul-Aug;51(4):563-6
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  • [Title] Diagnosis of adenoid cystic carcinoma of the lung by bronchial brushing: a case report.
  • BACKGROUND: A diagnosis of pulmonary adenoid cystic carcinoma on exfoliative cytology specimen is very uncommon.
  • No previous report of the diagnosis has been made on bronchial brushing cytologic material when the procedure preceded a tissue biopsy.
  • Bronchial brushing via bronchoscope was performed, revealing carcinoma cells consistent with an adenoid cystic carcinoma on cytology.
  • A bronchial biopsy and subsequent left upper lobectomy were performed, confirming the diagnosis of adenoid cystic carcinoma of the lung associated with tumor extension to the epithelial surface.
  • CONCLUSION: A diagnosis of bronchial adenoid cystic carcinoma is possible on bronchial brushing.
  • However, as a method in exfoliative cytology, the usefulness of bronchial brushing in diagnosing this tumor is limited by the neoplasm's proximity to the mucosal surface and whether the mucosa has been breached.
  • [MeSH-major] Bronchoalveolar Lavage. Carcinoma, Adenoid Cystic / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 17718122.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Carvalho CP, Barcellos AN, Teixeira DC, Sales Jde O, Silva Neto Rd: Adenoid cystic carcinoma of the external auditory canal. Braz J Otorhinolaryngol; 2008 Sep-Oct;74(5):794-6
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  • [Title] Adenoid cystic carcinoma of the external auditory canal.
  • Adenoid cystic carcinoma is a rare tumor originating from the salivary glands, especially when arise the external auditory canal.
  • We report a case of an adenoid cystic carcinoma arising the external auditory canal of 77 years old female patient, who complained hypoacusis and pain.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Ear Neoplasms / surgery. Ear, External

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  • (PMID = 19082366.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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87. Du Q, Wang Z: [Six cases of adenoid cystic carcinoma in external auditory canal]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Feb;20(4):158-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Six cases of adenoid cystic carcinoma in external auditory canal].
  • OBJECTIVE: By investigating the clinical and pathological features of adenoid cystic carcinoma in external auditory canal, we can improve our ability of diagnosis and treatment.
  • METHOD: A retrospective analysis was performed on 6 patients with adenoid cystic carcinoma in external auditory canal, including clinical manifestations, the therapy as well as the follow-up results.
  • CONCLUSION: Adenoid cystic carcinoma in external auditory canal grows slowly, so patients can live with the tumor for a long time.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Ear Canal. Ear Neoplasms

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  • (PMID = 16711439.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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88. Ko YH, Roh SY, Won HS, Jeon EK, Hong SH, Lee MA, Kang JH, Hong YS, Kim MS, Jung CK: Prognostic significance of nuclear survivin expression in resected adenoid cystic carcinoma of the head and neck. Head Neck Oncol; 2010;2:30
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  • [Title] Prognostic significance of nuclear survivin expression in resected adenoid cystic carcinoma of the head and neck.
  • We conducted this study to determine survivin expression in patients with adenoid cystic carcinoma (ACC) of the head and neck and to identify its clinical significance as a prognostic factor.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Cell Nucleus / metabolism. Head and Neck Neoplasms / diagnosis. Microtubule-Associated Proteins / analysis

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  • (PMID = 21034499.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Ki-67 Antigen; 0 / Microtubule-Associated Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC2988778
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89. Kawamata T, Harashima S, Kubo O, Hori T: Intrasellar remote metastasis from adenoid cystic carcinoma of parotid gland: case report. Endocr J; 2006 Oct;53(5):659-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrasellar remote metastasis from adenoid cystic carcinoma of parotid gland: case report.
  • Adenoid cystic carcinoma is a tumor of exocrine glands originating primarily from the minor and major salivary glands, lacrimal gland, bronchus, breast, and intestinal and genital tracts.
  • Intracranial remote metastasis from adenoid cystic carcinoma in salivary gland is quite rare.
  • The authors encountered a case of intrasellar remote metastasis from an adenoid cystic carcinoma of parotid gland origin, presenting with hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
  • To our knowledge, this is the first reported case of metastasis from an adenoid cystic carcinoma to intrasellar area.
  • A 78-year-old woman had an adenoid cystic carcinoma in the left parotid gland, which was resected surgically followed by local radiation therapy of 60 Gy.
  • Histopathological examination of the tumor specimens revealed adenoid cystic carcinoma, which had identical histological findings as those of the painful superficial cervical lymph nodes resected in the same operation.
  • Tumors such as the present case are easily confused with pituitary adenoma or craniopharyngioma.
  • Although rare, metastasis from tumors including those of salivary gland origin should be considered in the differential diagnosis of unusual pituitary tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology. Pituitary Neoplasms / secondary. Sella Turcica

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  • (PMID = 16902261.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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90. Ayadi K, Ayadi L, Daoud E, Mnif Z, Ben Mahfoudh K, Boudawara T, Mnif J: Adenoid cystic carcinoma of the parotid with facial nerve invasion. Tunis Med; 2010 Jan;88(1):46-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the parotid with facial nerve invasion.
  • BACKGROUND: Adenoid cystic carcinoma comprises approximately 10% of all epithelial salivary neoplasms and most frequently involves the parotid.
  • AIM: The authors report a case of parotid adenoid cystic carcinoma with invasion and spread via the facial nerve with an emphasis on radiologic features.
  • OBSERVATION: We report a case of a 47-year-old man presenting with a right submandibular mass evolving for 4 years.
  • Pathologic examination of the resected specimen revealed histological features of adenoid cystic carcinoma with intra neural invasion of the mastoid segment of the facial nerve.
  • CONCLUSION: This study confirms that multiplanar approach of MRI allows rapid detection of adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Facial Nerve / pathology. Parotid Neoplasms / diagnosis

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  • (PMID = 20415214.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Tunisia
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91. Garbyal RS, Kumar M, Bohra A: Adenoid cystic carcinoma of ceruminous gland: a case report. Indian J Pathol Microbiol; 2006 Oct;49(4):587-9
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  • [Title] Adenoid cystic carcinoma of ceruminous gland: a case report.
  • Adenoid cystic carcinoma of the external auditory canal (EAC) is a very rare malignant tumor and its diagnosis is frequently missed because of the superficial nature of biopsies.
  • The microscopic examination of the punch biopsy specimen of tumor revealed typical features of an adenoid cystic carcinoma.
  • While reporting the biopsies of external auditory canal one should keep the adenoid cystic carcinoma as one of the possible differentials, especially if the biopsy is superficial, problem is recurrent and histopathological features suggest the granulation tissue.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Cerumen. Ear Canal / pathology. Ear Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17183866.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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92. Xu YG, Hinshaw M, Longley BJ, Ilyas H, Snow SN: Cutaneous adenoid cystic carcinoma with perineural invasion treated by mohs micrographic surgery-a case report with literature review. J Oncol; 2010;2010:469049

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous adenoid cystic carcinoma with perineural invasion treated by mohs micrographic surgery-a case report with literature review.
  • We report a 58-year-old woman with cutaneous adenoid cystic carcinoma arising on the chest treated with Mohs micrographic surgery.
  • To date, only six other cases of cutaneous adenoid cystic carcinoma were reportedly managed by Mohs surgery.
  • Cutaneous adenoid cystic carcinoma has low potential for distant metastasis but is notorious for its aggressive infiltrative growth pattern, frequent perineural invasion, and high risk of local recurrence after excision.
  • We propose that Mohs surgery is an ideal method to achieve margin-free removal of cutaneous adenoid cystic carcinoma.

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  • (PMID = 20379385.001).
  • [ISSN] 1687-8469
  • [Journal-full-title] Journal of oncology
  • [ISO-abbreviation] J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2850546
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93. Pino Rivero V, Pantoja Hernández CG, González Palomino A, Trinidad Ramos G, Pardo Romero G, Marcos García M, Pereda Tamayo JM, Blasco Huelva A: [Adenoid cystic carcinoma of the larynx-hypopharynx. A case report and review of the literature]. An Otorrinolaringol Ibero Am; 2006;33(4):339-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma of the larynx-hypopharynx. A case report and review of the literature].
  • [Transliterated title] Carcinoma adenoide quístico de laringe-hipofaringe. A propósito de un caso y revisión de la literatura.
  • Laryngeal or hypopharyngeal localization of adenoid cystic carcinoma is rare due to the poor distribution of the accesory salivary glands in this area.
  • We report one case of such neoplasm on that area, with its diagnosis confirmed histologically.
  • We review the literature of this tumor whose prognosis is much worse than epidermoid or scamous carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery

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  • (PMID = 16910388.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 18
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94. Bell D, Zhao YJ, Rao PH, Weber RS, El-Naggar AK: Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongue. Head Neck Pathol; 2007 Dec;1(2):165-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongue.
  • We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY).
  • This finding supports a critical role for this event in the development of this tumor.
  • The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed.

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  • (PMID = 20614269.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / CA-16672
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807514
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Comparative genomic hybridizations / Cytogenetic / Spectral karyotyping / Translocations
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95. Prasad ML, Barbacioru CC, Rawal YB, Husein O, Wen P: Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Mod Pathol; 2008 Feb;21(2):105-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
  • Distinguishing adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma of the salivary glands is important for their management.
  • We studied the expression of several myoepithelial and basal/stem cell markers (smooth muscle actin, calponin, smooth muscle myosin heavy chain, metallothionein, maspin, and p63) by immunohistochemistry in 23 adenoid cystic carcinoma and 24 polymorphous low-grade adenocarcinoma, to identify the most useful marker or combination of markers that may help their diagnoses.
  • We noted diffuse expression of smooth muscle actin in 20 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (P<0.0001), calponin in 15 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (P<0.0001), smooth muscle myosin heavy chain in 15 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (P=0.001), metallothionein in 22 adenoid cystic carcinoma vs eight polymorphous low-grade adenocarcinoma (P<0.001), maspin in 22 adenoid cystic carcinoma vs 14 polymorphous low-grade adenocarcinoma, and p63 in 21 adenoid cystic carcinoma vs 14 polymorphous low-grade adenocarcinoma.
  • Diffuse smooth muscle actin expression showed the highest accuracy (91.5%) and positive predictive value (95.2%) for adenoid cystic carcinoma.
  • Thus, diffuse expression of smooth muscle actin, calponin, smooth muscle myosin heavy chain, and metallothionein was highly predictive of adenoid cystic carcinoma, whereas maspin and p63 were frequently expressed in both tumors.
  • In differentiating adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma, smooth muscle actin as a single ancillary test in support of the histological findings, appears to be as efficient as multiple immunohistochemical tests.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Epithelial Cells / metabolism. Myocytes, Smooth Muscle / metabolism. Neoplasm Proteins / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cluster Analysis. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Recurrence, Local. Salivary Glands, Minor / metabolism. Salivary Glands, Minor / pathology. Treatment Outcome


96. Messaoudi C, Larouk R, Baili S, Noui B, Benchaoui M, Benkadri H, Belbekri F: [Adenoid cystic carcinoma of the larynx. A case report and review of the literature]. Rev Laryngol Otol Rhinol (Bord); 2007;128(1-2):97-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma of the larynx. A case report and review of the literature].
  • [Transliterated title] Carcinome adénoïde kystique du larynx. Revue de la littérature, à propos d'un cas.
  • Cylindroma of the head and neck, known as "cystic adenoid carcinoma", begins more often at the expense of the all glandular structures of ectodermic origin, in particularly at the minor and principal salivary glands.
  • RESULTS: The patient is free of disease after six months of follow up.
  • CONCLUSION: The laryngeal cylindroma is rare.
  • The symptomatology does not show a proper characteristic, the diagnosis is a histological finding, and the natural evolution is marked by the very show development of this tumour the onset of cervical lymphatic adenopathy.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 17633677.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 33
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97. Franceschini G, Terribile D, Scafetta I, Magno S, Fabbri C, Chiesa F, Di Leone A, Moschella F, Scaldaferri A, Fragomeni S, Vellone V, Mulè A, Masetti R: Conservative treatment of a rare case of multifocal adenoid cystic carcinoma of the breast: case report and literature review. Med Sci Monit; 2010 Mar;16(3):CS33-39
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative treatment of a rare case of multifocal adenoid cystic carcinoma of the breast: case report and literature review.
  • BACKGROUND: Adenoid cystic carcinoma of the breast is a rare neoplasm accounting for 0.1% of all malignant breast tumors and presenting most commonly as a painful breast mass.
  • Compared with the more common histological forms of breast cancer, it has a more favorable prognosis and lymph node involvement or distant metastases seldom occur.
  • CASE REPORT: A unique case of multifocal adenoid cystic carcinoma of the breast presenting as a painful and well-defined lump and treated with conservative surgery with adjuvant radiotherapy is reported.
  • CONCLUSIONS: There is no consensus on the optimal management of this disease.
  • The authors found no other reports in the literature focusing on a conservative approach to multifocal adenoid cystic carcinoma.
  • [MeSH-major] Breast Neoplasms / therapy. Carcinoma, Adenoid Cystic / therapy

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  • (PMID = 20190690.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 39
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98. Boitte JP, Traoré J, Boukhet F, Mondié JM, Traoré M, Delbosc B: [Adenoid cystic carcinoma of the lacrimal gland in a 14-year-old girl]. J Fr Ophtalmol; 2006 Oct;29(8):937-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma of the lacrimal gland in a 14-year-old girl].
  • [Transliterated title] Carcinome adénoïde kystique de la glande lacrymale chez une enfant âgée de 14 ans.
  • The discovery of unilateral exophthalmia requires multidisciplinary care made all the more difficult in the case of a 14-year-old girl living in a tropical environment.
  • The child, C.A., resident of the town of Djenné in Mali, was examined for nonpulsate, nonretractile, left lateral unilateral exophthalmia, painful upon palpation of a left upper-external mass under the orbital rim.
  • The diagnosis was cylindroma, or adenoid cystic carcinoma.
  • Cylindromas or adenoid cystic carcinomas of the lachrymal gland are the second most common cause of epithelial tumors in this gland, which are characterized by a high degree of malignancy, a very high rate of recurrence, and a low survival rate at 5 years.
  • [MeSH-major] Carcinoma, Adenoid Cystic. Eye Neoplasms. Lacrimal Apparatus

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  • (PMID = 17075512.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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99. Chen SW, Huang HZ, Liu XQ: [Dynamic observation of lung metastasis model of adenoid cystic carcinoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 Sep;40(5):383-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Dynamic observation of lung metastasis model of adenoid cystic carcinoma].
  • OBJECTIVE: To form ACC-M-GFP cells by transfecting pEGFP-1 into ACC-M cells, and to build up lung metastasis model of adenoid cystic carcinoma for dynamic observation in simulated lung environment.
  • CONCLUSIONS: We successfully built up a lung metastasis model of adenoid cystic carcinoma for dynamic observation.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Green Fluorescent Proteins / genetics. Lung Neoplasms / secondary. Mouth Neoplasms / pathology. Neoplasms, Experimental

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  • (PMID = 16255921.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins
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100. Barisić A, Mahovlić V, Ovanin-Rakić A, Skopljanac-Macina L, Rajhvajn S, Juric D, Babić D: Cytologic characteristics of adenoid cystic carcinoma of the cervix uteri--case report. Coll Antropol; 2010 Mar;34(1):233-5
Hazardous Substances Data Bank. METHYLENE BLUE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic characteristics of adenoid cystic carcinoma of the cervix uteri--case report.
  • Adenoid cystic carcinoma is a rare malignancy, usually found in the salivary glands, although this unusual tumor can be found at other sites of the body.
  • In particular, regarding adenoid cystic carcinoma of the cervix (ACCC) most frequently reports are given for postmenopausal women.
  • In this respect, our work is one among very few in the literature that considers a cytologic picture of this uncommon cervix carcinoma.
  • Histology revealed the diagnosis of ACCC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Cervix Uteri / pathology. Uterine Cervical Neoplasms / pathology






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