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1. Shields JA, Shields CL, Marr BP, Eagle RC Jr: Sebaceous carcinoma of the caruncle. Cornea; 2006 Aug;25(7):858-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the caruncle.
  • PURPOSE: To report a case of sebaceous carcinoma of the caruncle.
  • Incisional biopsy elsewhere was interpreted histopathologically as invasive squamous cell carcinoma.
  • On the basis of the clinical findings, however, we suspected sebaceous carcinoma.
  • RESULTS: Histopathological examination disclosed infiltration of the caruncular stroma by lobules of a malignant neoplasm that had prominent cytoplasmic vacuoles, typical of sebaceous carcinoma.
  • CONCLUSION: Although it is best known to arise in the meibomian glands of the tarsus, sebaceous carcinoma can rarely arise in the caruncle and can be misinterpreted histopathologically as squamous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 17068467.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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2. McCluggage WG, Jamison J, Boyde A, Ganesan R: Vulval intraepithelial neoplasia with mucinous differentiation: report of 2 cases of a hitherto undescribed phenomenon. Am J Surg Pathol; 2009 Jun;33(6):945-9
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  • [Title] Vulval intraepithelial neoplasia with mucinous differentiation: report of 2 cases of a hitherto undescribed phenomenon.
  • The mucinous cells were bland with eccentrically placed small regular nuclei and were positive with CAM5.2, carcinoembryonic antigen, epithelial membrane antigen, and cytokeratin 7, markers that are typically positive in the neoplastic cells of Paget disease.
  • As far as we are aware, mucinous differentiation has not been described in VIN, although mucinous metaplasia has rarely been reported in non-neoplastic vulval skin and in cutaneous squamous cell carcinoma in situ at extravulval sites.
  • The main differential diagnosis of the cases we describe is Paget disease or coexistent VIN and Paget disease and the immunophenotype of the mucinous cells may further highlight the potential for misdiagnosis.
  • Other possible differential diagnoses include Pagetoid squamous cell carcinoma in situ (Pagetoid VIN), basal cell carcinoma with sebaceous differentiation, and VIN involving skin appendage structures.
  • [MeSH-major] Carcinoma in Situ / pathology. Mucins / metabolism. Papillomavirus Infections / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Differentiation. Cervical Intraepithelial Neoplasia / pathology. Cyclin-Dependent Kinase Inhibitor p16 / biosynthesis. Diagnosis, Differential. Female. Human papillomavirus 16. Humans. Neoplasms, Second Primary / metabolism. Neoplasms, Second Primary / pathology. Paget Disease, Extramammary / metabolism. Paget Disease, Extramammary / pathology. Polymerase Chain Reaction

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  • (PMID = 19238078.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Mucins
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3. Bouraoui S, Khaddar RK, Mokni M, Badri T, Azaiez MY, Dhahri AB: [Extrapalpebral sebaceous carcinoma]. Ann Dermatol Venereol; 2006 Feb;133(2):165-7
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  • [Title] [Extrapalpebral sebaceous carcinoma].
  • [Transliterated title] Carcinome sébacé extra-palpébral.
  • Extra ocular sebaceous carcinoma is a rare carcinoma of the skin known to have difficulties of diagnosis because of its polymorphism of clinical and histopathological findings.
  • His prognosis depends of the precocity of the diagnosis.
  • It suspected a squamous cell carcinoma.
  • The histologic findings revealed a sebaceous carcinoma in his mixed and moderately differentiated type.
  • COMMENTS: Sebaceous carcinoma exhibits a variety of histologic growth patterns and diverse clinical presentations that the diagnosis is often difficult.
  • We discuss incidence as well as clinical, histological and established the diagnosis and the prognosis of this aggressive neoplasm.
  • [MeSH-major] Carcinoma. Facial Neoplasms. Sebaceous Gland Neoplasms

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  • (PMID = 16508603.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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4. Dickinson RM, Young KM: Cutaneous mass aspirate from a Golden Retriever: "glandular guile". Vet Clin Pathol; 2005 Dec;34(4):421-4
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  • A 3-year-old, neutered, male Golden Retriever was presented for evaluation of a 10 X 9 X 5 mm, firm, red, raised, cutaneous mass located over the left cranial thorax and noted incidentally by the owner.
  • On cytologic evaluation of a fine-needle aspirate of the mass, the interpretation was a malignant tumor with predominantly mesenchymal features.
  • Differentials included liposarcoma, atypical amelanotic melanoma, anaplastic sarcoma, and anaplastic carcinoma.
  • Following complete excision of the mass, a diagnosis of sebaceous adenocarcinoma was made based on histologic features, positive immunostaining for pancytokeratin, and negative staining for vimentin, Melan-A, and S-100.
  • The unique and previously unreported cytologic features of this small, sebaceous adenocarcinoma were the extreme pleomorphism, including marked anisocytosis, anisokaryosis, and multinuclearity, and the paucity of epithelial features.

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  • (PMID = 16270273.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
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5. Rudkin AK, Muecke JS: Mitomycin-C as adjuvant therapy in the treatment of sebaceous gland carcinoma in high-risk locations. Clin Exp Ophthalmol; 2009 May;37(4):352-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mitomycin-C as adjuvant therapy in the treatment of sebaceous gland carcinoma in high-risk locations.
  • PURPOSE: To report on the use of Mitomycin-C as adjuvant therapy to excision and cryotherapy in patients with sebaceous gland carcinoma (SGC) in high-risk locations.
  • RESULTS: No patients had evidence of local recurrence or systemic disease.
  • [MeSH-major] Adenocarcinoma, Sebaceous / therapy. Antibiotics, Antineoplastic / therapeutic use. Conjunctival Neoplasms / therapy. Mitomycin / therapeutic use. Sebaceous Gland Neoplasms / therapy

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  • (PMID = 19594560.001).
  • [ISSN] 1442-9071
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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6. El Demellawy D, Escott N, Salama S, Alowami S: Sebaceoma of the external ear canal: an unusual location. Case report and review of the literature. J Cutan Pathol; 2008 Oct;35(10):963-6
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  • Sebaceous neoplasms of the external ear canal are extremely rare.
  • Only two cases of sebaceous neoplasms have been reported in the English literature, a sebaceous carcinoma and a sebaceous adenoma.
  • We highlight the differential diagnosis, particularly sebaceous carcinoma and basal cell carcinoma with sebaceous differentiation.
  • [MeSH-major] Ear Canal / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Sebaceous / pathology. Aged. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 18564279.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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7. Waseem M, Humayun S, Ayaz B: Sebaceous carcinoma of upper eyelid. J Coll Physicians Surg Pak; 2010 Jul;20(7):487-9
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  • [Title] Sebaceous carcinoma of upper eyelid.
  • Histopathology report of the tissue revealed it to be the palpebral sebaceous carcinoma, while lymph node showed reactive hyperplasia.
  • [MeSH-major] Eyelid Neoplasms / surgery. Sebaceous Gland Neoplasms / surgery

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  • (PMID = 20642955.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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8. Tanaka T, Sato H, Tada A, Moriya T, Wada Y, Nishida K: Case of orbital sebaceous carcinoma developing twenty-seven years after enucleation. Jpn J Ophthalmol; 2008 Jul-Aug;52(4):344-5
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  • [Title] Case of orbital sebaceous carcinoma developing twenty-seven years after enucleation.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eye Enucleation. Orbital Neoplasms / pathology. Postoperative Complications

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  • [Cites] Clin Exp Ophthalmol. 2004 Feb;32(1):103-5 [14746603.001]
  • [Cites] Arch Ophthalmol. 2001 May;119(5):764-7 [11346408.001]
  • [Cites] Surv Ophthalmol. 2005 Mar-Apr;50(2):103-22 [15749305.001]
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  • (PMID = 18773280.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
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9. Thosani MK, Marghoob A, Chen CS: Current progress of immunostains in Mohs micrographic surgery: a review. Dermatol Surg; 2008 Dec;34(12):1621-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In recent years, the application of immunostaining techniques has facilitated the successful removal of a number of common and less common cutaneous malignancies, including basal cell carcinoma, squamous cell carcinoma, malignant melanoma, dermatofibrosarcoma protuberans, microcystic adnexal carcinoma, sebaceous carcinoma, atypical fibroxanthoma, extramammary Paget's disease, and even sarcomas.

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  • (PMID = 19018832.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 127
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10. Stafanous SN: The switch flap in eyelid reconstruction. Orbit; 2007 Dec;26(4):255-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: Eight cases of large full-thickness eyelid defects resulting from excision of tumours such as basal cell carcinoma (bcc), squamous cell carcinoma (scc) and sebaceous gland carcinoma (sgc) were taken for repair using the switch flap technique.
  • RESULTS: Out of the eight cases of eyelid defects, one was from squamous cell carcinoma, three were from sebaceous gland carcinoma, and four were from infiltrative basal cell carcinoma.

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  • (PMID = 18097963.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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11. Kim Y, Scolyer RA, Chia EM, Steven D, Ghabrial R: Eccrine porocarcinoma of the upper eyelid. Australas J Dermatol; 2005 Nov;46(4):278-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Incisional biopsy of the lesion revealed a malignant tumour that was thought to possibly represent a sebaceous carcinoma.
  • However, a subsequent wide surgical excision showed that the tumour was an eccrine porocarcinoma, a rare sweat gland adenocarcinoma arising from the acrosyringium.
  • [MeSH-major] Carcinoma / pathology. Eccrine Glands / pathology. Eyelid Diseases / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16197432.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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12. Rizzardi C, Perin T, Schneider M, Rossi D, Brollo A, Melato M, Canzonieri V: Carcinoma of the uterine cervix with squamous and sebaceous differentiation. Int J Gynecol Pathol; 2009 May;28(3):292-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the uterine cervix with squamous and sebaceous differentiation.
  • Sebaceous neoplasms, including carcinoma, can exceptionally arise in extracutaneous sites.
  • We present the third known case of carcinoma with sebaceous differentiation in the uterine cervix.
  • Histologic and immunohistochemical features suggested a metaplastic process within an otherwise usual squamous cell carcinoma.
  • We speculate that, by analogy with the skin where the epidermis and the 3 types of adnexa have a common embryologic origin from basal cell layer of the superficial ectoderm, it is possible that endocervical reserve cells, in addition to the well-known capacity of squamous differentiation, retain the potential to give rise to appendages including sebaceous glands.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Sebaceous Glands / pathology. Uterine Cervical Neoplasms / pathology

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  • (PMID = 19620949.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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13. Sa HS, Woo KI, Kim YD: Reverse modified Hughes procedure for uppereyelid reconstruction. Ophthal Plast Reconstr Surg; 2010 May-Jun;26(3):155-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The underlying diagnoses included sebaceous gland carcinoma (13), squamous cell carcinoma (3), and Merkel cell carcinoma (1).

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  • (PMID = 20489537.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Thomas CJ, Wood GC, Marks VJ: Mohs micrographic surgery in the treatment of rare aggressive cutaneous tumors: the Geisinger experience. Dermatol Surg; 2007 Mar;33(3):333-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Retrospective chart review of 26,000 cases treated with MMS at the Geisinger Medical Center Department of Dermatology during a 16-year period with the following diagnoses: poorly differentiated squamous cell carcinoma (PDSCC), dermatofibrosarcoma protuberans (DFSP), microcystic adnexal carcinoma (MAC), extramammary Paget's disease (EMPD), Merkel cell carcinoma (MCC), and sebaceous carcinoma (SEB CA).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Merkel Cell / surgery. Carcinoma, Squamous Cell / surgery. Child. Child, Preschool. Dermatofibrosarcoma / surgery. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Paget's Disease, Mammary / surgery. Retrospective Studies. Treatment Outcome

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  • (PMID = 17338692.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Lukáts O: [Oncological principles of surgery in the periorbital region]. Magy Onkol; 2005;49(1):47-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study is to describe the most common malignant periorbital tumours and principles of their surgical treatment.
  • The most common malignant tumours of the eyelids are: basocellular carcinoma, squamocellular carcinoma, sebaceous carcinoma and malignant melanoma.
  • Malignant tumours of the eyelids are fairly rare.
  • Diagnosis in some of the cases is difficult, since the first signs of the tumours are small changes on the eyelid margin or eyelid skin.
  • Focal loss of the eyelashes could be the first sign of a malignant tumour.
  • Therefore, early diagnosis and total tumour removal--regardless of the anatomical borders--as well as immediate reconstruction are important in the treatment of eyelid tumours.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / surgery. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Humans. Melanoma / surgery. Ophthalmologic Surgical Procedures / methods. Sebaceous Gland Neoplasms / surgery. Surgical Procedures, Operative / methods

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  • (PMID = 15902334.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Number-of-references] 23
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16. Kazakov DV, Calonje E, Zelger B, Luzar B, Belousova IE, Mukensnabl P, Michal M: Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases. Am J Dermatopathol; 2007 Jun;29(3):242-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases.
  • The authors report a small series of sebaceous carcinoma developing in nevus sebaceus of Jadassohn (also known as organoid nevus) and analyze similar cases reported in the literature.
  • All sebaceous carcinomas manifested unquestionable architectural (asymmetry, invasive growth) and cytological features of a carcinoma (cellular and nuclear pleomorphism, plentiful atypical mitoses, necroses en masse), demonstrated unambiguous sebaceous differentiation in the form of mature sebocytes, and lacked other differentiations.
  • The sebaceous carcinoma was always accompanied by other benign or malignant adnexal lesions such as sebaceoma, syringocystadenoma papilliferum, syringocystadenocarcinoma papilliferum, trichoblastoma, tricholemmoma, desmoplastic tricholemmoma, or syringoma.
  • The analysis of the previously published material and our cases indicates that sebaceous carcinoma arising in organoid nevus has a female predilection and tends to occur in elderly patients.
  • It may involve any site where nevus sebaceus typically occurs.
  • It may arise alone, but it occurs more frequently as part of multiple benign and malignant adnexal tumors.
  • The tumor seems to be a low-grade carcinoma in terms of clinical behavior.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 17519621.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Gomaa AH, Yaar M, Bhawan J: Cutaneous immunoreactivity of D2-40 antibody beyond the lymphatics. Am J Dermatopathol; 2007 Feb;29(1):18-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Podoplanin not only is highly expressed in lymphatic endothelium but also in other cell types, including sebaceous carcinoma cells.
  • Using the D2-40 antibody, our purpose was to evaluate expression of podoplanin in sebaceous glands of normal skin.
  • Strong immunostaining with D2-40 antibody was observed at the periphery of sebaceous glands and in skin lymphatic endothelium of all specimens, demonstrating that podoplanin is expressed in sebaceous glands of normal skin.
  • [MeSH-major] Antibodies, Monoclonal / metabolism. Endothelium, Lymphatic / metabolism. Membrane Glycoproteins / metabolism. Sebaceous Glands / metabolism. Skin / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Carcinoma / metabolism. Carcinoma / pathology. Female. Humans. Male. Middle Aged. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 17284957.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
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18. Pusiol T, Zorzi MG, Piscioli F: Grading of skin sebaceous carcinoma. Hum Pathol; 2010 Mar;41(3):459
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  • [Title] Grading of skin sebaceous carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Sebaceous Gland Neoplasms / pathology

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  • [CommentOn] Hum Pathol. 1982 Feb;13(2):113-22 [7076199.001]
  • (PMID = 20159235.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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19. Deprez M, Uffer S: Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol; 2009 May;31(3):256-62
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  • Eyelid tumors are the most common neoplasm in daily ophthalmology practice and encompass a wide variety of benign and malignant tumors.
  • Benign tumors largely predominated over malignant ones, representing 84% of cases in this series, and the 5 most frequent subtypes were squamous cell papilloma (26%), seborrheic keratosis (21%), melanocytic nevus (20%), hidrocystoma (8%), and xanthoma/xanthelasma (6%).
  • Basal cell carcinoma was the most frequent malignant tumor (86%), followed by squamous cell carcinoma (7%) and sebaceous carcinoma (3%).
  • For several tumor subtypes, there was a poor correlation between clinical and histological diagnosis, stressing the numerous pitfalls in the diagnosis of eyelid tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Child. Child, Preschool. Female. Hidrocystoma / pathology. Humans. Infant. Keratosis, Seborrheic / pathology. Male. Middle Aged. Nevus, Pigmented / pathology. Papilloma / pathology. Predictive Value of Tests. Retrospective Studies. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology. Xanthomatosis / pathology. Young Adult

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  • (PMID = 19384066.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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20. Sebastián Villalón-López J, Arturo Valle-Mejía C, Patiño-Lara A, Moreno-Pérez Bertha A, Alejo Muñoz-López J, Alcantar-Andrade A: Supraestructure maxillectomy and orbital exenteration for treatment of basal cell carcinoma of inferior eyelid: case report and review. J Cancer Res Ther; 2005 Jul-Sep;1(3):132-5
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  • [Title] Supraestructure maxillectomy and orbital exenteration for treatment of basal cell carcinoma of inferior eyelid: case report and review.
  • Basal cell carcinoma (BCC) is the most frequent type of skin cancer in humans, with cumulative exposure to ultraviolet radiation (UVR) as important risk factor for development of the illness as such as severe solar burns during childhood or adolescence.
  • Orbital exenteration is also used for treatment of malignancies of ocular tissues, mainly squamous cell carcinoma, sebaceous cell carcinoma and BCC.
  • The case of a 77 year-old patient is presented with BCC of inferior eyelid of 14 years duration, formerly managed with radiotherapy and, due to recurrent illness and invasion to the maxillary antrum; he needed supraestructure maxillectomy with left orbital exenteration.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Eyelid Neoplasms / surgery. Maxilla / surgery. Orbit Evisceration / methods
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / drug therapy. Humans. Male

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  • (PMID = 17998643.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 15
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21. Lan MC, Lan MY, Lin CZ, Ho DM, Ho CY: Sebaceous carcinoma of the eyelid with neck metastasis. Otolaryngol Head Neck Surg; 2007 Apr;136(4):670-1
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  • [Title] Sebaceous carcinoma of the eyelid with neck metastasis.
  • [MeSH-major] Carcinoma / secondary. Eyelid Neoplasms / pathology. Head and Neck Neoplasms / secondary

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  • (PMID = 17418274.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Hernández JF, Santiago RS: [Sebaceous gland carcinoma of the eyelids]. Cir Cir; 2006 Nov-Dec;74(6):509-10
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  • [Title] [Sebaceous gland carcinoma of the eyelids].
  • [Transliterated title] Carcinoma de glándulas sebáceas de los párpados.
  • [MeSH-major] Eyelid Neoplasms / genetics. Neoplastic Syndromes, Hereditary / genetics. Sebaceous Gland Neoplasms / genetics

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  • [CommentOn] Cir Cir. 2004 Jan-Feb;72(1):47-53 [15087053.001]
  • (PMID = 17244511.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Comment; Letter
  • [Publication-country] Mexico
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23. Takamura H, Yamashita H: Clinicopathological analysis of malignant eyelid tumor cases at Yamagata university hospital: statistical comparison of tumor incidence in Japan and in other countries. Jpn J Ophthalmol; 2005 Sep-Oct;49(5):349-54
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  • [Title] Clinicopathological analysis of malignant eyelid tumor cases at Yamagata university hospital: statistical comparison of tumor incidence in Japan and in other countries.
  • PURPOSE: To report the clinical and histopathological features of malignant eyelid tumor cases treated in our clinic.
  • We also compared the differences in the frequency of malignant eyelid tumor in various regions of Japan and worldwide.
  • METHODS: Retrospectively, we studied the records of the 38 cases of malignant eyelid tumor treated in Yamagata University Hospital over the last 17 years.
  • RESULTS: Data from our clinic: Among the total of 38 cases, 15 cases (39.5%) were diagnosed as basal cell carcinoma, 11 cases (28.9%) as sebaceous gland carcinoma, and 4 cases (10.5%) as squamous cell carcinoma.
  • In addition, three cases were malignant melanoma, two adenocarcinoma, one Merkel cell carcinoma, one malignant peripheral nerve sheath tumor, and one malignant lymphoma.
  • The prognosis of the cases with basal cell carcinoma and squamous cell carcinoma was good, and that of the other tumors was relatively poor.
  • During the same period, in Caucasians, basal cell carcinoma constituted about 80%-90% of the malignant eyelid tumors, whereas in Japan and Asian countries, basal cell carcinoma, sebaceous gland carcinoma, and squamous cell carcinoma each constituted about 20%-40%.
  • CONCLUSIONS: A racial difference in the incidence of basal cell carcinoma, sebaceous gland carcinoma, and squamous cell carcinoma can be considered in making a diagnosis.

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  • [Journal-full-title] Japanese journal of ophthalmology
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24. Khong JJ, Muecke J: Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia. Br J Ophthalmol; 2006 Jul;90(7):819-22
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  • RESULTS: One to three 7 day cycles of topical MMC 0.04% four times a day were given to 59 eyes with localised corneal-conjunctival intraepithelial neoplasia (CIN), 19 eyes with diffuse CIN, six eyes with recurrent CIN, one eye with ocular surface squamous cell carcinoma, three eyes with primary acquired melanosis (PAM) with atypia, nine eyes with conjunctival malignant melanoma (MM), two eyes with sebaceous carcinoma with pagetoid spread, and one eye with recurrent atypical fibroxanthoma.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / drug therapy. Carcinoma in Situ / drug therapy. Carcinoma, Squamous Cell / drug therapy. Conjunctival Neoplasms / drug therapy. Corneal Diseases / drug therapy. Female. Follow-Up Studies. Histiocytoma, Benign Fibrous / drug therapy. Humans. Lacrimal Apparatus Diseases / chemically induced. Lacrimal Duct Obstruction / chemically induced. Male. Melanoma / drug therapy. Melanosis / drug therapy. Retrospective Studies

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  • (PMID = 16672325.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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25. Alzaraa A, Ghafoor I, Yates A, Dhebri A: Sebaceous carcinoma of the skin of the breast: a case report. J Med Case Rep; 2008;2:276
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  • [Title] Sebaceous carcinoma of the skin of the breast: a case report.
  • INTRODUCTION: Sebaceous gland tumours are rare and their presence should be considered as a marker for Muir-Torre Syndrome, alerting to search for an occult malignancy.
  • CASE PRESENTATION: A 43-year-old Caucasian female patient underwent excision of a sebaceous cyst.
  • Histopathology confirmed a sebaceous carcinoma.
  • CONCLUSION: Sebaceous carcinoma should be excised completely and followed-up for the detection of possible metastases.

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  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
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26. Renn CN, Rübben A: [Sebaceous gland carcinoma]. Hautarzt; 2007 Nov;58(11):926-8
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  • [Title] [Sebaceous gland carcinoma].
  • [MeSH-major] Adenocarcinoma, Sebaceous. Sebaceous Gland Neoplasms
  • [MeSH-minor] Aged. Cheek. Follow-Up Studies. Humans. Male. Sebaceous Glands / pathology. Treatment Outcome

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  • (PMID = 17952392.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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27. Carvalho J, Fullen D, Lowe L, Su L, Ma L: The expression of CD23 in cutaneous non-lymphoid neoplasms. J Cutan Pathol; 2007 Sep;34(9):693-8
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  • CD23 staining was seen in 42% (8/19) of microcystic adnexal carcinoma (MAC), while no staining was observed in tumor cells of desmoplastic trichoepithelioma, morpheaform basal cell carcinoma and syringoma.
  • All mammary and extramammary Paget's disease were labeled with CD23.
  • In comparison, pagetoid Bowen's disease, melanoma in situ and sebaceous carcinoma exhibited negative staining.
  • In addition, CD23 reacted diffusely with cutaneous mucinous eccrine carcinoma in a manner similar to breast or colonic adenocarcinoma.
  • CONCLUSION: CD23 appears to be a reliable immunohistochemical marker of the eccrine/apocrine secretory coil and helpful in identifying sweat gland tumors of such origin.
  • CD23 is a useful addition to the diagnostic immunohistochemical panels for Paget's disease.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Receptors, IgE / metabolism. Sweat Gland Neoplasms / metabolism

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  • (PMID = 17696916.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, IgE
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28. Rigas PK, Kase S, Rao NA: Expression of alpha-crystallins in human sebaceous carcinoma of the eyelid. Eur J Ophthalmol; 2009 Sep-Oct;19(5):702-7
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  • [Title] Expression of alpha-crystallins in human sebaceous carcinoma of the eyelid.
  • This study used immunohistochemistry to examine the expression of alphaA-crystallin and alphaB-crystallin in human sebaceous carcinoma tissues.
  • METHODS: Nine patients with sebaceous carcinoma of the eyelid underwent excision of the eyelid or orbital exenteration.
  • RESULTS: In the noncancerous eyelid, crystallins were weakly and homogeneously expressed in the Meibomian gland lobules.
  • In eyelids with sebaceous carcinoma, alphaA-crystallin and alphaB-crystallin were highly expressed in 4 cases, where the cytoplasmic immunoreactivity was heterogeneously detected in the tumor cells.
  • A statistically significant correlation was observed between expression levels of alphaA-crystallin and alphaB-crystallin in sebaceous carcinomas (p=0.012).
  • All sebaceous carcinoma tissues contained mitotic tumor cells, which showed predominantly perinuclear immunoreactivity of alphaB-crystallin.
  • CONCLUSIONS: Crystallins are expressed in human sebaceous carcinomas including mitotic cells.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Eyelid Neoplasms / metabolism. Sebaceous Gland Neoplasms / metabolism. alpha-Crystallin A Chain / metabolism. alpha-Crystallin B Chain / metabolism

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  • (PMID = 19787585.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30 EY003040-30; United States / NEI NIH HHS / EY / R01 EY017347; United States / NEI NIH HHS / EY / EY015714; United States / NEI NIH HHS / EY / R01 EY017347-03; United States / NEI NIH HHS / EY / P30 EY003040; United States / NEI NIH HHS / EY / EY03040; United States / NEI NIH HHS / EY / R01 EY015714
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Crystallin A Chain; 0 / alpha-Crystallin B Chain
  • [Other-IDs] NLM/ NIHMS218754; NLM/ PMC3062472
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29. Calder KB, Khalil FK, Schlauder S, Cualing HD, Morgan MB: Immunohistochemical expression of survivin in cutaneous sebaceous lesions. Am J Dermatopathol; 2008 Dec;30(6):545-8
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  • [Title] Immunohistochemical expression of survivin in cutaneous sebaceous lesions.
  • Survivin overexpression has been demonstrated in numerous malignancies including cutaneous squamous cell carcinoma and melanoma.
  • To date, there are no studies evaluating the expression of survivin in sebaceous neoplasms.
  • METHODS: Immunohistochemical expression of survivin was evaluated in a total of 20 extraocular sebaceous neoplasms: sebaceous hyperplasia (SH, 8), sebaceous adenoma (SA, 8), and sebaceous carcinoma (SC, 4).
  • These findings demonstrate the potential diagnostic utility of survivin, further assisting in the microscopic differentiation of benign and malignant sebaceous neoplasms.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Adenoma / metabolism. Microtubule-Associated Proteins / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Glands / metabolism. Sebaceous Glands / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Case-Control Studies. Cell Nucleus / metabolism. Diagnosis, Differential. Female. Humans. Hyperplasia / diagnosis. Hyperplasia / metabolism. Hyperplasia / pathology. Inhibitor of Apoptosis Proteins / metabolism. Male. Middle Aged

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  • (PMID = 19033926.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
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30. Maheshwari R: Review of orbital exenteration from an eye care centre in Western India. Orbit; 2010 Feb;29(1):35-8
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  • Except for one case all exenteration were for malignant neoplasm.
  • Histopathological classification of the neoplasm were sebaceous carcinoma (4 cases), basal cell carcinoma (3 cases), squamous cell carcinoma (3 cases), adenoid cystic carcinoma (1 case), transitional cell carcinoma (1 case), malignant fibrous histiocytoma (1 case), lymphoma (1 case) and mucormycosis (1 case).
  • CONCLUSION: Majority of exenterations performed were for neglected ocular or adnexal malignant lesions that could have been avoided provided patients reported earlier for treatment.

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  • (PMID = 20302408.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 20
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31. Muthusamy K, Halbert G, Roberts F: Immunohistochemical staining for adipophilin, perilipin and TIP47. J Clin Pathol; 2006 Nov;59(11):1166-70
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  • BACKGROUND: The presence of lipid in the cell cytoplasm is useful for supporting the diagnosis of sebaceous gland carcinoma (SGC).
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Biomarkers, Tumor / analysis. Eyelid Neoplasms / diagnosis. Lipids / analysis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Adipocytes / immunology. Antibodies, Monoclonal / immunology. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Carrier Proteins. DNA-Binding Proteins / analysis. Diagnosis, Differential. Humans. Intracellular Signaling Peptides and Proteins / analysis. Membrane Proteins. Paraffin Embedding. Peptides / analysis. Phosphoproteins / analysis. Pregnancy Proteins / analysis. Vesicular Transport Proteins

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  • [Cites] Am J Dermatopathol. 1999 Oct;21(5):426-31 [10535570.001]
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  • (PMID = 16556662.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Lipids; 0 / Membrane Proteins; 0 / PLIN3 protein, human; 0 / Peptides; 0 / Phosphoproteins; 0 / Pregnancy Proteins; 0 / Vesicular Transport Proteins; 0 / perilipin 1; 0 / perilipin 2
  • [Other-IDs] NLM/ PMC1860497
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32. Izumi M, Tang X, Chiu CS, Nagai T, Matsubayashi J, Iwaya K, Umemura S, Tsuboi R, Mukai K: Ten cases of sebaceous carcinoma arising in nevus sebaceus. J Dermatol; 2008 Nov;35(11):704-11
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  • [Title] Ten cases of sebaceous carcinoma arising in nevus sebaceus.
  • Although nevus sebaceus is known to develop various types of secondary neoplasms, it rarely causes carcinoma and only 14 cases of secondary sebaceous carcinoma have been reported.
  • In this study, 10 cases of sebaceous carcinoma arising in nevus sebaceus were collected.
  • Sebaceous carcinoma arising in nevus sebaceous predominantly occurred on the scalp (8/10) of elderly women (mean age, 67.7 years).
  • We found several pathological features of sebaceous carcinoma; that is, made up mainly of germinative cells, moderate nuclear atypia without pleomorphism and many mitoses (4-28/10 high-power field).
  • Adipophilin and perilipin antibodies highlighted lipid drops in the cytoplasm of the malignant cells in all cases.
  • In two cases there were coexisting benign-looking sebaceous lesions at the periphery of the main cancer nodule, and in these lesions p53 showed low positivity compared with the clearly malignant area.
  • All cases were treated by excision of the malignant lesion, with or without inclusion of the nevus sebaceus.
  • With these specific pathological and immunohistochemical findings using adipophilin, perilipin and p53, we have to consider the possibility that there is a tendency to underdiagnose secondary sebaceous carcinomas in nevus sebaceus.
  • These clinicopathological features of sebaceous carcinomas developing in the nevus sebaceus seem to indicate different biological entities from de novo sebaceous carcinoma.
  • [MeSH-major] Carcinoma / secondary. Nevus, Sebaceous of Jadassohn / pathology. Sebaceous Gland Neoplasms / secondary. Skin / pathology


33. Eisen DB, Michael DJ: Sebaceous lesions and their associated syndromes: part I. J Am Acad Dermatol; 2009 Oct;61(4):549-60; quiz 561-2
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  • [Title] Sebaceous lesions and their associated syndromes: part I.
  • Sebaceous neoplasms have long been a source of confusion to dermatologists and pathologists alike.
  • Sebaceous lesions represent a broad spectrum of interesting entities that range from hamartomas, hyperplasias, and benign tumors to highly malignant neoplasms.
  • This article discusses the clinical and pathologic features of sebaceous hyperplasia, nevus sebaceous of Jadassohn, sebaceous adenoma, seboacanthoma, sebaceous epithelioma, sebaceoma, mantleoma, basal cell carcinoma with sebaceous differentiation, sebomatricoma (sebomatrixoma), and sebaceous carcinoma.
  • [MeSH-major] Sebaceous Gland Diseases / classification. Sebaceous Gland Diseases / pathology. Sebaceous Gland Neoplasms / classification. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 19751879.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 145
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34. Tan O, Ergen D, Arslan R: Sebaceous carcinoma on the scalp. Dermatol Surg; 2006 Oct;32(10):1290-3
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  • [Title] Sebaceous carcinoma on the scalp.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 17034383.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Rangel J, McCalmont TH: Intracytoplasmic adipophilin immunopositivity: a pitfall in the distinction of metastatic renal carcinoma from sebaceous carcinoma. J Cutan Pathol; 2010 Dec;37(12):1193-5
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  • [Title] Intracytoplasmic adipophilin immunopositivity: a pitfall in the distinction of metastatic renal carcinoma from sebaceous carcinoma.
  • [MeSH-major] Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Membrane Proteins / metabolism. Neoplasm Proteins / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 20950361.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / perilipin 2
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36. Koreen IV, Flint A, Nelson CC, Frueh BR, Elner VM: Nondiagnostic conjunctival map biopsies for sebaceous carcinoma. Arch Ophthalmol; 2009 Aug;127(8):961-3
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  • [Title] Nondiagnostic conjunctival map biopsies for sebaceous carcinoma.
  • OBJECTIVE: To compare the prevalence of nondiagnostic conjunctival map biopsies in patients with extensive pagetoid sebaceous carcinoma (defined as involvement of 3 or 4 quadrants of the ocular surface) and in patients without extensive pagetoid tumor (defined as involvement of 1 or 2 quadrants of the ocular surface).
  • METHODS: Retrospective medical record and pathologic specimen review of 20 patients treated for sebaceous carcinoma at a tertiary care center.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma in Situ / pathology. Conjunctival Neoplasms / pathology

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  • (PMID = 19667331.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30 EY007003; United States / NEI NIH HHS / EY / P30 EY007003
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS327247; NLM/ PMC3208231
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37. Liang H, Wu H, Giorgadze TA, Sariya D, Bellucci KS, Veerappan R, Liegl B, Acs G, Elenitsas R, Shukla S, Youngberg GA, Coogan PS, Pasha T, Zhang PJ, Xu X: Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin. Am J Surg Pathol; 2007 Feb;31(2):304-10
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  • [Title] Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin.
  • Distinction of primary skin adnexal carcinomas from cutaneous metastasis of adenocarcinomas is challenging.
  • In this study, we evaluated podoplanin immunoreactivity in a series of primary skin adnexal tumors and adenocarcinomas metastatic to skin using a D2-40 antibody.
  • The initial test series were composed of a total of 93 cases including 32 primary skin adnexal carcinomas, 46 benign primary adnexal tumors, and 15 cutaneous metastatic adenocarcinomas.
  • We found that variable D2-40 reactivity was seen in all of the primary cutaneous carcinomas including sebaceous carcinomas (10/10), squamous cell carcinomas (10/10), porocarcinomas (4/4), trichilemmal carcinomas (4/4), skin adnexal carcinomas not otherwise specified (4/4), and in the majority of benign skin adnexal tumors.
  • To confirm the initial findings and to further explore the utility of podoplanin reactivity in the distinction of these tumors, we also examined a test set of 35 unknown cases, including 21 adenocarcinomas metastatic to skin and 14 primary adnexal tumors, in a blinded fashion.
  • Of the 22 podoplanin negative cases, 20 were proven to be metastatic adenocarcinoma.
  • Our results suggest that podoplanin can be a useful tool to distinguish primary skin adnexal carcinomas form adenocarcinomas metastatic to skin with high sensitivity (94.5%) and specificity (97.2%).
  • [MeSH-major] Adenocarcinoma / secondary. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / pathology. Membrane Glycoproteins / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Humans. Predictive Value of Tests. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology. Single-Blind Method

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  • (PMID = 17255777.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
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38. Dim-Jamora KC, Perone JB: Management of cutaneous tumors with mohs micrographic surgery. Semin Plast Surg; 2008 Nov;22(4):247-56
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  • We discuss the use of Mohs micrographic surgery for the following cutaneous tumors: basal cell carcinoma, squamous cell carcinoma, melanoma in situ, dermatofibrosarcoma protuberans, Merkel cell carcinoma, microcystic adnexal carcinoma, atypical fibroxanthoma, and sebaceous carcinoma.

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  • (PMID = 20567701.001).
  • [ISSN] 1536-0067
  • [Journal-full-title] Seminars in plastic surgery
  • [ISO-abbreviation] Semin Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2884874
  • [Keywords] NOTNLM ; Mohs micrographic surgery / cutaneous oncology / skin cancer
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39. Kumabe A, Kawase T, Miura K, Tada Y, Masubuchi T, Kamata SE, Tanada S, Kubo A, Tajima Y, Shigematsu N: Sebaceous carcinoma of the parotid gland: F-18 FDG PET/CT findings. Clin Nucl Med; 2010 Apr;35(4):260-2
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  • [Title] Sebaceous carcinoma of the parotid gland: F-18 FDG PET/CT findings.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Fluorodeoxyglucose F18. Parotid Neoplasms / diagnosis. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 20305416.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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40. Arits A, van Marion AM, Thissen CA, Kloos R, Kelleners-Smeets NW: Development and progression of a periorbital sebaceous gland carcinoma in situ. Acta Derm Venereol; 2010 Sep;90(5):529-30
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  • [Title] Development and progression of a periorbital sebaceous gland carcinoma in situ.
  • [MeSH-major] Adenoma / diagnosis. Carcinoma in Situ / diagnosis. Eyelid Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Biopsy. Disease Progression. Humans. Male. Neoplasm Invasiveness. Time Factors. Treatment Outcome

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  • (PMID = 20814637.001).
  • [ISSN] 1651-2057
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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41. Plaza JA, Ortega PF, Stockman DL, Suster S: Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases. J Cutan Pathol; 2010 Apr;37(4):403-10
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  • [Title] Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases.
  • Thirty seven primary tumors and 42 cutaneous metastatic adenocarcinomas were evaluated.
  • The 37 primary cutaneous tumors included 14 cases of benign adnexal tumors, 9 malignant skin adnexal neoplasms, and 14 primary squamous and basal cell carcinomas.
  • The 42 metastatic adenocarcinomas all corresponded to metastases from patients with a well-documented history of a primary tumor at another location.
  • We found variable positivity with podoplanin in all primary cutaneous neoplasms including spiradenoma (6/6), hidradenoma (2/4), cylindroma (3/3), desmoplastic trichilemmoma (1/1), poorly differentiated squamous cell carcinoma (4/4), sebaceous carcinoma (1/1), basal cell carcinoma (4/10), trichilemmal carcinoma (2/2), eccrine carcinoma (3/3), microcystic adnexal carcinoma (1/1), adnexal carcinoma NOS (1/1), and porocarcinoma (1/1).
  • The results of our study suggest that the combined expression of p63 and podoplanin are a useful adjunct for the diagnosis of skin tumors in the clinical setting of a questionable metastasis and may be relatively specific for distinguishing primary skin tumors from metastatic carcinomas to the skin.
  • [MeSH-major] Adenocarcinoma / metabolism. Membrane Glycoproteins / metabolism. Membrane Proteins / metabolism. Skin / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry

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  • (PMID = 20377670.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / PDPN protein, human
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42. Park SJ, Wee WR, Lee JH, Kim MK: Primary sebaceous carcinoma of the corneaoscleral limbus with pagetoid recurrence. Korean J Ophthalmol; 2009 Jun;23(2):104-7
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  • [Title] Primary sebaceous carcinoma of the corneaoscleral limbus with pagetoid recurrence.
  • We report a sebaceous carcinoma confined to the corneoscleral limbus without involvement of the eyelid.
  • Histopathologic examination revealed a sebaceous carcinoma.
  • This report shows that the ulcerative mass which is confined to only the corneoscleral limbus may be a sebaceous carcinoma even without eyelid involvement.
  • Topical mitomycin C may be effective for treating pagetoid spread of sebaceous carcinoma of limbal origin.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eye Neoplasms / pathology. Limbus Corneae / pathology. Neoplasm Recurrence, Local. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Biological Dressings. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Ophthalmologic Surgical Procedures / methods

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  • [Cites] Br J Ophthalmol. 2004 May;88(5):718-9 [15090432.001]
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  • (PMID = 19568359.001).
  • [ISSN] 2092-9382
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2694285
  • [Keywords] NOTNLM ; Conjunctiva / Limbus / Mitomycin C / Pagetoid recurrence / Sebaceous carcinoma
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43. Yoon JS, Kim SH, Lee CS, Lew H, Lee SY: Clinicopathological analysis of periocular sebaceous gland carcinoma. Ophthalmologica; 2007;221(5):331-9
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  • [Title] Clinicopathological analysis of periocular sebaceous gland carcinoma.
  • BACKGROUND: We analyzed the clinicopathological features and prognosis in patients with periocular sebaceous gland carcinoma.
  • METHODS: Retrospectively, we studied the records of 24 cases of sebaceous gland carcinoma treated in our clinic between 1999 and 2004.
  • The reviewed data included demographic information, initial clinical and histopathological diagnosis, anatomic tumor location, details of treatment, tumor involvement of resection margin, and outcomes such as local recurrence, distant metastasis and survival.
  • RESULTS: Local recurrence developed in 6 cases (25%) at a median of 20 months from initial diagnosis.
  • Only 2 patients (8.3%) died of systemic metastasis to brain and bone from primary lacrimal gland carcinoma.
  • Early aggressive management is required in sebaceous gland carcinoma of the lacrimal gland, as its mortality is much higher than that of eyelid origin.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Eyelid Neoplasms / pathology. Eyelid Neoplasms / surgery. Sebaceous Gland Neoplasms / pathology. Sebaceous Gland Neoplasms / surgery

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17728556.001).
  • [ISSN] 1423-0267
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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44. Xu XL, Li B, Sun XL, Li LQ, Ren RJ, Gao F, Jonas JB: Eyelid neoplasms in the Beijing Tongren Eye Centre between 1997 and 2006. Ophthalmic Surg Lasers Imaging; 2008 Sep-Oct;39(5):367-72
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  • RESULTS: Of the 2,639 eyelid specimens, 2,276 (86.2%) were benign and 363 (13.8%) were malignant.
  • The most common malignant or semi-malignant tumors were basal cell carcinomas, sebaceous gland carcinomas, lymphomas, squamous cell carcinomas, and malignant melanomas.
  • The mean age at diagnosis was 41 years for benign lesions and 60 years for malignant tumors.
  • CONCLUSION: At the BeijingTongren Eye Centre between 1997 and 2006, the predominant non-benign eyelid tumors were basal cell carcinoma and sebaceous gland carcinoma, followed by lymphoma.

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  • (PMID = 18831417.001).
  • [ISSN] 1542-8877
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Arias-Santiago S, Soriano Hernández MI, Aneiros-Fernández J, Gutiérrez Salmerón MT, Aneiros Cachaza J, Naranjo Sintes R: [Facial sebaceous carcinoma: Muir-Torre syndrome]. Med Clin (Barc); 2010 Jul 17;135(6):291
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  • [Title] [Facial sebaceous carcinoma: Muir-Torre syndrome].
  • [Transliterated title] Carcinoma sebáceo de localización facial: síndrome de Muir-Torre.
  • [MeSH-major] Carcinoma / diagnosis. Facial Neoplasms / diagnosis. Muir-Torre Syndrome / diagnosis. Neoplasms, Second Primary / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / genetics. Aged, 80 and over. Appendiceal Neoplasms / genetics. Diagnosis, Differential. Endometrial Neoplasms / genetics. Female. Humans. Ileal Neoplasms / genetics. Keratoacanthoma / diagnosis. Lymphoma, Follicular / genetics

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  • (PMID = 19833357.001).
  • [ISSN] 0025-7753
  • [Journal-full-title] Medicina clínica
  • [ISO-abbreviation] Med Clin (Barc)
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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46. Kazakov DV, Kutzner H, Spagnolo DV, Rütten A, Mukensnabl P, Michal M: What is extraocular cutaneous sebaceous carcinoma in situ? Am J Dermatopathol; 2010 Dec;32(8):857-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] What is extraocular cutaneous sebaceous carcinoma in situ?
  • [MeSH-major] Carcinoma / classification. Carcinoma in Situ / classification. Sebaceous Gland Neoplasms / classification. Terminology as Topic

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  • [CommentOn] Am J Dermatopathol. 2010 Dec;32(8):854-5 [20885288.001]
  • (PMID = 20966738.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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47. Wakabayashi A, Tanese K, Yamamoto K, Tanomogi H, Miyakawa S: Extraocular sebaceous carcinoma expressing oestrogen receptor alpha and human epidermal growth factor receptor 2. Clin Exp Dermatol; 2010 Jul;35(5):546-8
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  • [Title] Extraocular sebaceous carcinoma expressing oestrogen receptor alpha and human epidermal growth factor receptor 2.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Estrogen Receptor alpha / metabolism. Head and Neck Neoplasms / pathology. Receptor, Epidermal Growth Factor / metabolism. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 19874363.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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48. Bogner PN, Su LD, Fullen DR: Cluster designation 5 staining of normal and non-lymphoid neoplastic skin. J Cutan Pathol; 2005 Jan;32(1):50-4
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  • The majority of benign and malignant apocrine lesions demonstrated strong focal (36%, n=11)-to-diffuse (64%, n=16) staining.
  • Microcystic adnexal carcinoma demonstrated focal staining of deeper ductal structures (71%, n=7), whereas desmoplastic trichoepithelioma and basal cell carcinoma showed only rare positive cells.
  • All cases of mammary (n=7) and extramammary (n=8) Paget's disease labeled diffusely for CD5.
  • Pagetoid Bowen's disease (n=6), intraepidermal sebaceous carcinoma (n=3), nor melanoma in situ (n=6) showed any CD5 staining.
  • CONCLUSIONS: Immunohistochemical staining for CD5 is extremely useful in the differential diagnosis of pagetoid epidermal lesions and will mark mammary and extramammary Paget's disease, but not pagetoid Bowen's disease, melanoma in situ, or sebaceous carcinoma.
  • [MeSH-minor] Cell Count. Diagnosis, Differential. Humans. Immunohistochemistry. Paget Disease, Extramammary / diagnosis. Paget's Disease, Mammary / diagnosis. Retrospective Studies

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  • (PMID = 15660655.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD5
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49. Sawyer AR, McGoldrick RB, Mackey S, Powell B, Pohl M: Should extraocular sebaceous carcinoma be investigated using sentinel node biopsy? Dermatol Surg; 2009 Apr;35(4):704-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Should extraocular sebaceous carcinoma be investigated using sentinel node biopsy?
  • [MeSH-major] Nose Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology. Sentinel Lymph Node Biopsy

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  • (PMID = 19415798.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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50. Xu X, Jia R, Zhou Y, Song X, Fan X: Investigation of vasculogenic mimicry in sebaceous carcinoma of the eyelid. Acta Ophthalmol; 2010 Aug;88(5):e160-4
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  • [Title] Investigation of vasculogenic mimicry in sebaceous carcinoma of the eyelid.
  • The purpose of this study was to investigate whether sebaceous carcinomas of the eyelid exhibit VM and to determine whether these fluid-conducting patterns are associated with clinicopathologic features, the number of microvessels and the levels of endothelial growth factor (VEGF) and matrix metalloprotease-2 (MMP-2) in tumours.
  • METHODS: Forty paraffin-embedded samples of sebaceous carcinoma of the eyelid were collected, along with complete clinical and pathologic data for all the cases.
  • CONCLUSIONS: Vasculogenic mimicry is present in sebaceous carcinoma of the eyelid making it an unfavourable prognosis sign.
  • MMP-2 is associated with VM formation in sebaceous carcinoma of the eyelid.
  • [MeSH-major] Adenocarcinoma, Sebaceous / blood supply. Eyelid Neoplasms / blood supply. Matrix Metalloproteinase 2 / metabolism. Neovascularization, Pathologic / diagnosis. Sebaceous Gland Neoplasms / blood supply. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 20553231.001).
  • [ISSN] 1755-3768
  • [Journal-full-title] Acta ophthalmologica
  • [ISO-abbreviation] Acta Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; EC 3.4.24.24 / Matrix Metalloproteinase 2
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51. Dixon A: Rare skin cancers in general practice. Aust Fam Physician; 2007 Mar;36(3):141-3
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  • Histology of the superior lesion revealed sebaceous carcinoma.
  • This is an uncommon yet aggressive cutaneous malignancy derived from sebaceous glands.
  • [MeSH-major] Skin Neoplasms / diagnosis. Skin Neoplasms / therapy
  • [MeSH-minor] Australia. Family Health. Family Practice. Humans. Male. Neoplasms, Radiation-Induced / diagnosis. Neoplasms, Radiation-Induced / therapy. Sarcoma / diagnosis. Sarcoma / therapy. Sebaceous Gland Neoplasms / diagnosis. Sebaceous Gland Neoplasms / therapy

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  • (PMID = 17339977.001).
  • [ISSN] 0300-8495
  • [Journal-full-title] Australian family physician
  • [ISO-abbreviation] Aust Fam Physician
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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52. Rizvi SA, Maheshwari V: Advanced upper eyelid sebaceous gland carcinoma with deep orbital extension. J Surg Case Rep; 2010;2010(1):5
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  • [Title] Advanced upper eyelid sebaceous gland carcinoma with deep orbital extension.
  • Sebaceous gland carcinomas (SGC) are highly malignant lid tumors which originate from meibomian glands and rarely from the gland of Zeis, sebaceous gland of caruncle, eyebrows and periocular skin.
  • In many cases correct diagnosis of SGC is delayed because of its ability to masquerade as a variety of other ocular conditions.
  • A differential diagnosis of sebaceous gland carcinoma or preseptal cellulitis was made.
  • A diagnosis of meibomian gland carcinoma was confirmed on histopathology.
  • This is a report of an advanced sebaceous gland carcinoma with deep orbital extension.
  • An early diagnosis and appropriate treatment may decrease the long term morbidity and extend the survival rate of such patients.

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  • [Copyright] © JSCR.
  • (PMID = 24945508.001).
  • [ISSN] 2042-8812
  • [Journal-full-title] Journal of surgical case reports
  • [ISO-abbreviation] J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3649079
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53. Güerrissi JO, Quiroga JP: Adnexal carcinomas of the head and neck. Indian J Plast Surg; 2008 Jul;41(2):229-34
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  • Adnexal carcinomas of the skin are rare and they derive from structures such as sweat glands, sebaceous glands, and hair follicles.
  • Between 1998 and 2004, eight patients with malignant adnexal tumors of the head and neck were treated in the Plastic Surgery Service in Argerich Hospital in Buenos Aires, Argentina.
  • Four (50%) of them had malignant cylindromas, two (25%) had sebaceous carcinoma, and the other two (25%) syringoid eccrine carcinoma.

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  • [Cites] Dermatologica. 1980;160(6):361-70 [6248388.001]
  • [Cites] Br J Plast Surg. 1990 Nov;43(6):702-5 [2175228.001]
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  • (PMID = 19753272.001).
  • [ISSN] 0970-0358
  • [Journal-full-title] Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • [ISO-abbreviation] Indian J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2740523
  • [Keywords] NOTNLM ; Adnexal carcinomas / adnexal tumors / skin cancer
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54. Bettini G, Morini M, Mandrioli L, Capitani O, Gandini G: CNS and lung metastasis of sebaceous epithelioma in a dog. Vet Dermatol; 2009 Aug;20(4):289-94
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  • [Title] CNS and lung metastasis of sebaceous epithelioma in a dog.
  • Sebaceous epithelioma is a common canine cutaneous neoplasm characterized by a preponderance of basaloid cells with few well-differentiated sebocytes.
  • This case report presents the clinical and pathological features of a sebaceous epithelioma of the upper lip with a highly aggressive behaviour.
  • The patient was a 9-year-old female dachshund that developed local recurrence 11 months after the excision of the primary sebaceous epithelioma and multiple lung and central nervous system metastases 5 months later.
  • The designation epitheliomatous sebaceous carcinoma has been suggested for aggressive sebaceous epitheliomas, although differential criteria are still to be determined.
  • [MeSH-major] Brain Neoplasms / veterinary. Carcinoma / veterinary. Dog Diseases / pathology. Lung Neoplasms / veterinary. Skin Neoplasms / veterinary

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  • (PMID = 19552699.001).
  • [ISSN] 1365-3164
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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55. Samarasinghe V, Marsden J, Roberts C: Sebaceous carcinoma of the scalp presenting with nodal metastasis. J Plast Reconstr Aesthet Surg; 2010 Dec;63(12):2193-4
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  • [Title] Sebaceous carcinoma of the scalp presenting with nodal metastasis.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Scalp. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 20558120.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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56. Cibull TL, Thomas AB, Badve S, Billings SD: Sebaceous carcinoma of the nipple. J Cutan Pathol; 2008 Jun;35(6):608-10
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  • [Title] Sebaceous carcinoma of the nipple.
  • Sebaceous carcinoma (SC) is an uncommon neoplasm that usually presents as an ocular or extraocular cutaneous lesion of the head and neck.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Breast Neoplasms / pathology. Nipples / pathology
  • [MeSH-minor] Aged, 80 and over. Disease-Free Survival. Female. Humans. Treatment Outcome

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  • (PMID = 18466364.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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57. Moshitch-Moshkovitz S, Tsarfaty G, Kaufman DW, Stein GY, Shichrur K, Solomon E, Sigler RH, Resau JH, Vande Woude GF, Tsarfaty I: In vivo direct molecular imaging of early tumorigenesis and malignant progression induced by transgenic expression of GFP-Met. Neoplasia; 2006 May;8(5):353-63
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  • [Title] In vivo direct molecular imaging of early tumorigenesis and malignant progression induced by transgenic expression of GFP-Met.
  • These mice ubiquitously expressed GFP-Met in specific epithelial and endothelial cells and displayed enhanced GFP-Met fluorescence in sebaceous glands.
  • Thirty-two percent of males spontaneously developed adenomas, adenocarcinomas, and angiosarcomas in their lower abdominal sebaceous glands.
  • Approximately 70% of adenocarcinoma tumors metastasized to the kidneys, lungs, or liver.
  • Quantitative subcellular-resolution intravital imaging revealed very high levels of GFP-Met in tumor lesions and in single isolated cells surrounding them, relative to normal sebaceous glands.

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  • (PMID = 16790084.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA093990; United States / NCI NIH HHS / CA / P50CA93990
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 147336-22-9 / Green Fluorescent Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-met
  • [Other-IDs] NLM/ PMC1592452
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58. Kiyosaki K, Nakada C, Hijiya N, Tsukamoto Y, Matsuura K, Nakatsuka K, Daa T, Yokoyama S, Imaizumi M, Moriyama M: Analysis of p53 mutations and the expression of p53 and p21WAF1/CIP1 protein in 15 cases of sebaceous carcinoma of the eyelid. Invest Ophthalmol Vis Sci; 2010 Jan;51(1):7-11
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  • [Title] Analysis of p53 mutations and the expression of p53 and p21WAF1/CIP1 protein in 15 cases of sebaceous carcinoma of the eyelid.
  • PURPOSE: The purpose of this study was to detect mutation of the p53 gene, to assess its relationship with p53 or p21(WAF1/CIP1) expression, and to evaluate the correlation between p53 mutation or p21(WAF1/CIP1) expression and clinicopathologic findings in sebaceous carcinoma of the eyelid.
  • METHODS: Fifteen conventional paraffin-embedded samples of sebaceous carcinoma of the eyelid were analyzed.
  • CONCLUSIONS: Among human cancers, sebaceous carcinoma of the eyelid may be one of those showing most frequent mutation of the p53 gene, which may not be caused by exposure to UV. p21(WAF1/CIP1) downregulation may be associated with lymph node metastasis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / genetics. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Eyelid Neoplasms / genetics. Genes, p53 / genetics. Point Mutation. Sebaceous Gland Neoplasms / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19628749.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Protein p53
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59. Ahn SH, Park SY: Sebaceous lymphadenocarcinoma of parotid gland. Eur Arch Otorhinolaryngol; 2006 Oct;263(10):940-2
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  • [Title] Sebaceous lymphadenocarcinoma of parotid gland.
  • The sebaceous lymphadenocarcinoma of the salivary glands is extremely rare and represents carcinomatous transformation of sebaceous lymphadenoma.
  • A patient who presented with a recent increase of a left infraauricular mass, of more than 10 years duration, underwent surgery.
  • The microscopic examination revealed a typical sebaceous lymphadenoma with transition to a sebaceous adenocarcinoma.
  • After postoperative adjuvant radiotherapy, the patient remains disease-free at 24 months postoperatively.
  • We here report a fifth case of this tumor and the youngest age at diagnosis among reported cases.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Adenolymphoma / diagnosis. Parotid Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis

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  • [Cites] Ann Diagn Pathol. 2003 Aug;7(4):236-9 [12913846.001]
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  • (PMID = 16786364.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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60. Ornellas AA, Frota R, Lopes da Silva LF, Dauster B, Quirino R, de Santos Schwindt AB, Pereira MR: Sebaceous carcinoma of the penis. Urol Int; 2009;82(4):477-80
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  • [Title] Sebaceous carcinoma of the penis.
  • Sebaceous carcinoma is a very aggressive malignant tumor, derived from the adnexal epithelium of sebaceous glands.
  • Extraocular sebaceous carcinoma is a very uncommon neoplasm usually localized on the head and neck.
  • To our knowledge, there are only 2 previously reported cases of sebaceous carcinoma on the penis.
  • We report the clinicopathologic data on 3 additional cases of sebaceous carcinoma arising in the penis.
  • [MeSH-major] Carcinoma. Penile Neoplasms

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19506419.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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61. Wu CY: Muir-Torre syndrome: extraocular sebaceous carcinoma with adenocarcinoma of colon in a 76-year-old man. Clin Exp Dermatol; 2009 Oct;34(7):e399-400
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  • [Title] Muir-Torre syndrome: extraocular sebaceous carcinoma with adenocarcinoma of colon in a 76-year-old man.
  • [MeSH-major] Adenocarcinoma / diagnosis. Colonic Neoplasms / diagnosis. Facial Neoplasms / diagnosis. Muir-Torre Syndrome / diagnosis

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  • (PMID = 19549240.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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62. Nolan L, Eccles D, Cross E, Crawford G, Beck N, Bateman A, Ottensmeier C: First case report of Muir-Torre syndrome associated with non-small cell lung cancer. Fam Cancer; 2009;8(4):359-62
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  • The eponymous Muir-Torre syndrome (MTS) is a clinical variant of hereditary non polyposis colorectal cancer, and is defined as an autosomal dominant condition with simultaneous sebaceous neoplasms of the skin and visceral malignant disease resulting from germline mutations in the DNA mismatch repair (MMR) genes.
  • Other clearly associated tumours include endometrial adenocarcinomas, urothelial transitional cell carcinomas, upper gastrointestinal adenocarcinomas, sebaceous adenomas and ovarian (often mucinous) carcinomas.
  • Here we report the first recorded case of adenocarcinoma of the lung with loss of MMR gene function to be identified in a patient with MTS.
  • The MMR deficient lung tumour demonstrated less aggressive clinical behaviour compared with a synchronous MMR proficient lung adenocarcinoma.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / genetics. Lung Neoplasms / genetics. Muir-Torre Syndrome / genetics


63. Shields JA, Demirci H, Marr BP, Eagle RC Jr, Shields CL: Sebaceous carcinoma of the ocular region: a review. Surv Ophthalmol; 2005 Mar-Apr;50(2):103-22
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  • [Title] Sebaceous carcinoma of the ocular region: a review.
  • Sebaceous carcinoma of the ocular region is a malignant neoplasm that is being recognized more frequently and managed by innovative techniques of local resection, cryotherapy, topical chemotherapy, and radiotherapy, resulting in improved visual and systemic prognosis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 15749305.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 168
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64. Tohya T, Ogura T, Nishi K, Nishi H, Kuriwaki K: Muir-Torre syndrome associated with endometrial carcinoma. Int J Clin Oncol; 2008 Dec;13(6):559-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Muir-Torre syndrome associated with endometrial carcinoma.
  • Muir-Torre syndrome (MTS) is an autosomaldominant skin condition of genetic origin, characterized by tumors of the sebaceous glands or keratoacanthomas that are associated with malignant visceral diseases.
  • Here we report a woman with no family history of colorectal cancer who developed endometrial carcinoma, stage 3a, at 49 years of age and at age 51 years, developed two skin tumors, a nasal squamous cell carcinoma and a sebaceous carcinoma of the right eyelid.
  • Although MTS associated with endometrial carcinoma is rare, patients with endometrial carcinoma should undergo evaluation for visceral malignancies (mainly colon cancer) and sebaceous skin lesions, regardless of whether or not there is a family history of colorectal cancer.

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  • (PMID = 19093187.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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65. Al-Shobaili HA, AlGhamdi KM, Al-Ghamdi WA: Cystic sebaceous carcinoma: is it a constant pathognomic marker for Muir-Torre syndrome? J Drugs Dermatol; 2007 May;6(5):540-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic sebaceous carcinoma: is it a constant pathognomic marker for Muir-Torre syndrome?
  • Sebaceous carcinoma (SC) is a rare and aggressive cutaneous neoplasm.
  • Cystic presentation of sebaceous neoplasm is rare.
  • So far, cystic sebaceous neoplasia (CSN) has been reported only in association with Muir-Torre syndrome (MTS).
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Neoplasms, Cystic, Mucinous, and Serous / pathology. Skin Neoplasms / pathology

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  • (PMID = 17679191.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Kinkor Z, Meciarová I, Havlícek F: [Primary sebaceous carcinoma of the breast; three casuistic reports]. Ceska Gynekol; 2010 Feb;75(1):50-3
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  • [Title] [Primary sebaceous carcinoma of the breast; three casuistic reports].
  • [Transliterated title] Primární sebaceózní karcinom prsu - klinicko-morfologická analogie kozní adnexální léze? Popis trí prípadů.
  • OBJECTIVE: Presentation of three cases of primary sebaceous carcinoma of the breast particularly focusing on the clinical, biological and molecular genetic aspects regarding their possible pathogenetic relationship to the Muir-Torre and Lynch syndrome.
  • Reviewed are basic principles of miscosatellite instability and dysregulations of mismatch repair genes by these inherited tumorous syndromes especially looking for morphologic and fenotypic parallels between sebaceous carcinomas of the breast and their cutaneous counterparts.
  • RESULTS: In three women aged 51 to 69 was diagnosed primary sebaceous carcinoma of the breast with maximum dimension ranged from 13 to 41 mm.
  • Follow-up available in two women, both without regional metastasis, revealed no local or distant progression of the disease.
  • The histology consisted of conventional G1-2 invasive duct carcinoma in all cases and sebaceous differentiation represented 10-40% of all neoplastic population.
  • Familial tumorous stigmas were not evident and subsequent close clinical monitoring in two of the patients tracked down no intern malignancy, including cutaneous sebaceous lesion.


67. Hoffmann M, Braun-Falco M: Rhinophyma-like sebaceous carcinoma. J Eur Acad Dermatol Venereol; 2009 Oct;23(10):1216-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rhinophyma-like sebaceous carcinoma.
  • [MeSH-major] Rhinophyma / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 19368609.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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68. Karcioglu ZA: Sebaceous carcinoma of the eyelids. Ophthalmology; 2005 Sep;112(9):1641; author reply 1641-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the eyelids.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology

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  • [CommentOn] Ophthalmology. 2004 Dec;111(12):2151-7 [15582067.001]
  • [CommentOn] Ophthalmology. 2004 Dec;111(12):2149-50 [15582066.001]
  • (PMID = 16139675.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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69. Burns SJ, Foss AJ, Butler TK: Outcome of periocular sebaceous gland carcinoma. Ophthal Plast Reconstr Surg; 2005 Sep;21(5):353-5
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  • [Title] Outcome of periocular sebaceous gland carcinoma.
  • PURPOSE: To determine the long-term outcome of periocular sebaceous gland carcinoma and factors predictive of tumor recurrence.
  • METHODS: A retrospective case note review of all patients with periocular sebaceous gland carcinoma treated at the Queen's Medical Centre, Nottingham, United Kingdom, between 1992 and 1999.
  • CONCLUSIONS: In our unit, the best prognostic factor for sebaceous gland carcinoma is a histologic report confirming complete excision of the tumor, whatever the tumor size or pattern of spread identified.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 16234697.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Buitrago W, Joseph AK: Sebaceous carcinoma: the great masquerader: emgerging concepts in diagnosis and treatment. Dermatol Ther; 2008 Nov-Dec;21(6):459-66
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  • [Title] Sebaceous carcinoma: the great masquerader: emgerging concepts in diagnosis and treatment.
  • Sebaceous carcinoma (SC) is a rare tumor with a high rate of local recurrence and metastasis to lymph nodes and organs.
  • It frequently masquerades as inflammatory conditions or as other tumors leading to delay in diagnosis, inappropriate treatment and increased morbidity and mortality.
  • Sebaceous carcinoma is associated with Muir-Torre syndrome, a genetic condition presenting with sebaceous skin tumors associated with internal malignancy.
  • Greater awareness and understanding of SC and its behavior has led to earlier diagnosis and appropriate treatment.
  • [MeSH-major] Adenocarcinoma, Sebaceous / therapy. Eye Neoplasms / therapy. Sebaceous Gland Neoplasms / therapy

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  • (PMID = 19076624.001).
  • [ISSN] 1529-8019
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 74
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71. Murthy R, Honavar SG, Burman S, Vemuganti GK, Naik MN, Reddy VA: Neoadjuvant chemotherapy in the management of sebaceous gland carcinoma of the eyelid with regional lymph node metastasis. Ophthal Plast Reconstr Surg; 2005 Jul;21(4):307-9
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  • [Title] Neoadjuvant chemotherapy in the management of sebaceous gland carcinoma of the eyelid with regional lymph node metastasis.
  • A 55-year-old Asian Indian woman who had recurrent sebaceous gland carcinoma of the left lower eyelid with orbital extension and regional lymph node metastasis was treated with neoadjuvant chemotherapy, using a combination of carboplatin and 5-fluorouracil.
  • The patient had limited morbidity and was free of local, regional, and systemic disease at 26 months of follow-up.
  • [MeSH-major] Adenocarcinoma, Sebaceous / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Eyelid Neoplasms / drug therapy. Orbital Neoplasms / drug therapy. Sebaceous Gland Neoplasms / drug therapy

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  • (PMID = 16052148.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; U3P01618RT / Fluorouracil
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72. Fernandes BF, Martins CM, Heckler LV, Arthurs B, Codère F, Burnier MN Jr: Sebaceous carcinoma of the eyelid. ANZ J Surg; 2009 Apr;79(4):306-7
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  • [Title] Sebaceous carcinoma of the eyelid.
  • [MeSH-major] Eyelid Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis

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  • [CommentOn] ANZ J Surg. 2008 Mar;78(3):158-63 [18269479.001]
  • (PMID = 19432724.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Australia
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73. Scuderi S, Giaccone M, D'Errico E, Maorenzic MA, Fontanellaa M, Castellano I, Zanon C, Gaetini AM: Aggressive sebaceous carcinoma of the head. Chir Ital; 2009 May-Jun;61(3):401-4
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  • [Title] Aggressive sebaceous carcinoma of the head.
  • Cutaneous sebaceous carcinoma (SC) is a rare malignancy deriving from the adnexal epithelium of the sebaceous glands.
  • Extraocular SC is reported to be less aggressive than orbital sebaceous carcinoma and rarely metastasizes.
  • We report a case of sebaceous carcinoma of the scalp, characterised by highly aggressive behaviour and huge invasion of the intracranial space.
  • The patient was a 79-year-old woman who developed an infiltrating sebaceous carcinoma followed by lymph-node metastases shortly after excision of the primary lesion, resulting in death.
  • In this case, aggressive biological behaviour was observed in a carcinoma arising in an extraorbital area, although it has traditionally been considered a less aggressive neoplasm.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Head and Neck Neoplasms / pathology. Scalp / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 19694247.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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74. Higgins HJ, Voutsalath M, Holland JM: Muir-torre syndrome: a case report. J Clin Aesthet Dermatol; 2009 Aug;2(8):30-2
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  • Muir-Torre syndrome is an autosomal dominant genodermatosis associated with sebaceous neoplasms and visceral malignancies.
  • Characteristic sebaceous neoplasms include sebaceous adenoma, sebaceous carcinoma, sebaceoma, and keratoacanthoma with sebaceous differentiation.
  • The clinical and histological features of a patient with Muir-Torre syndrome who had two sebaceous adenomas, multiple basal cell carcinomas, and frontal bossing in association with colon cancer are presented in this report.

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  • [Cites] Arch Dermatol. 1968 Nov;98(5):549-51 [5684233.001]
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  • (PMID = 20729952.001).
  • [ISSN] 1941-2789
  • [Journal-full-title] The Journal of clinical and aesthetic dermatology
  • [ISO-abbreviation] J Clin Aesthet Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2923964
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75. Russell HC, Chadha V, Lockington D, Kemp EG: Topical mitomycin C chemotherapy in the management of ocular surface neoplasia: a 10-year review of treatment outcomes and complications. Br J Ophthalmol; 2010 Oct;94(10):1316-21
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  • METHODS: This study is a retrospective review of patients treated with topical MMC for ocular surface neoplasia, including primary acquired melanosis (PAM), melanoma, corneal-conjunctival intraepithelial neoplasia (CCIN), squamous cell carcinoma (SCC) and sebaceous gland carcinoma (SGC).
  • Data regarding diagnosis, short- and long-term outcomes, and short- and long-term complications, were recorded.
  • Overall, 26% developed recurrent disease at a mean of 13 months post treatment.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Eye Neoplasms / drug therapy. Mitomycin / administration & dosage. Sebaceous Gland Neoplasms / drug therapy

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  • (PMID = 20530655.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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76. Atique-Tacla M, Paves L, Pereira MD, Manso PG: [Exenteration: a retrospective study]. Arq Bras Oftalmol; 2006 Sep-Oct;69(5):679-82
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  • Data regarding sex, age, race, primary lesion site, visual acuity at the moment of diagnosis, previous surgeries related to the exenteration, type of performed surgery, histopathologic diagnosis, postoperative complications and use of adjuvant treatment were collected.
  • All lesions that led to exenteration were malignant neoplasias; however, none were metastatic.
  • Cases were also classified as squamous cell carcinoma (eleven cases), basal cell carcinoma (four cases), sebaceous gland carcinoma (two cases), rhabdomyosarcoma (two cases), mucoepidermoid carcinoma (one case) and adnexal microcistic carcinoma (one case).
  • Visual acuity at the moment of diagnosis ranged from 20/40 to no light perception.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Eye Neoplasms / surgery. Orbit Evisceration. Surgical Flaps
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Child, Preschool. Conjunctival Neoplasms / diagnosis. Continental Population Groups. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postoperative Period. Retrospective Studies. Sex Distribution. Visual Acuity

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  • (PMID = 17187134.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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77. Asadi-Amoli F, Khoshnevis F, Haeri H, Jahanzad I, Pazira R, Shahsiah R: Comparative examination of androgen receptor reactivity for differential diagnosis of sebaceous carcinoma from squamous cell and basal cell carcinoma. Am J Clin Pathol; 2010 Jul;134(1):22-6
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  • [Title] Comparative examination of androgen receptor reactivity for differential diagnosis of sebaceous carcinoma from squamous cell and basal cell carcinoma.
  • Sebaceous carcinoma (SEB) is the most important malignant tumor of the eyelid.
  • Early diagnosis and proper treatment significantly improve the outcome.
  • SEB should be differentiated histopathologically from basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
  • In this study, the expression of androgen receptor (AR) in SEB, SCC, and BCC was evaluated.
  • AR was positive in all 19 SEB cases.
  • AR is a sensitive marker for SEB, especially in less differentiated tumors.
  • Along with other markers and morphologic features, AR can be helpful in the diagnosis of SEB and its differentiation from SCC and BCC.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Eyelid Neoplasms / diagnosis. Receptors, Androgen / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Male

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  • (PMID = 20551262.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Androgen
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78. Pornpanich K, Chindasub P: Eyelid tumors in Siriraj Hospital from 2000-2004. J Med Assoc Thai; 2005 Nov;88 Suppl 9:S11-4
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  • RESULTS: There were 53 (17.8%) inflammatory conditions, 212 (71.4%) benign eyelid tumors and 32 (10.8%) malignant eyelid tumors.
  • These 32 malignant eyelid tumors included 13 sebaceous gland carcinomas, 12 basal cell carcinomas, 3 malignant melanomas, 2 squamous cell carcinomas, 1 apocrine adenocarcinoma and 1 metastatic carcinoma.
  • CONCLUSION: The majority of eyelid lesions were benign eyelid tumors while malignant eyelid tumors contributed 10.8% of the total eyelid lesions.
  • Sebaceous gland carcinoma was the most common eyelid tumor found in their present study that was consistent with other studies from Asian countries.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Eyelid Neoplasms / epidemiology. Sebaceous Gland Neoplasms / epidemiology

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  • (PMID = 16681045.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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79. Xu XL, Li B, Sun XL, Li LQ, Ren RJ, Gao F: [Clinical and pathological analysis of 2639 cases of eyelid tumors]. Zhonghua Yan Ke Za Zhi; 2008 Jan;44(1):38-41
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  • The 5 leading eyelid malignant tumors were basal cell carcinoma, sebaceous gland carcinoma, lymphoma, squamous cell carcinoma and melanoma.
  • The mean age at diagnosis was 61 years for basal cell carcinoma and sebaceous gland carcinoma, 57 years and 52 years for squamous cell carcinoma and melanoma, respectively, and 48 years for lymphoma.
  • There was no significant sex predilection in basal cell carcinoma and sebaceous gland carcinoma.
  • Melanoma and lymphoma occurred more commonly in women, whereas squamous cell carcinoma occurred more commonly in men.
  • CONCLUSIONS: Basal cell carcinoma and sebaceous gland carcinoma were the most common malignant eyelid tumors, and lymphoma ranked third and had an increasing trend.
  • The malignant tumors occurred predominantly in the elderly of 60 years and above.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology. Lymphoma / pathology

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  • (PMID = 18510241.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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80. Prayaga AK, Loya AC, Gottimukkala SR, Digumarti RR, Maddali LS, Challa S: Cytologic features of primary malignant tumors of skin and adnexae. Acta Cytol; 2008 Nov-Dec;52(6):702-9
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  • [Title] Cytologic features of primary malignant tumors of skin and adnexae.
  • STUDY DESIGN: Cases of primary malignant tumors of skin and adnexae diagnosed on cytology with histopathology confirmation were retrieved from case records of 1998-2005.
  • RESULTS: Thirty primary malignant tumors of skin and adnexae were analyzed.
  • Melanoma was the most common (n=12), followed by squamous cell carcinoma (SCC) (n=5).
  • There were 3 basal cell carcinomas and 2 cases each of sebaceous carcinoma, Paget's disease of the breast and lymphoma.
  • There were single cases of eccrine carcinoma, malignant trichilemmal tumor, undifferentiated carcinoma and extramedullary myeloid cell tumor.
  • CONCLUSION: Cytodiagnosis of primary malignant tumors of skin and adnexae is possible based on morphology and clinical presentation.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / pathology. Breast Neoplasms / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Cytodiagnosis. Humans. Lymphatic Metastasis. Medical Records. Melanoma / pathology. Paget's Disease, Mammary / pathology

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  • (PMID = 19068675.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Kazakov DV, Calonje E, Rütten A, Glatz K, Michal M: Cutaneous sebaceous neoplasms with a focal glandular pattern (seboapocrine lesions): a clinicopathological study of three cases. Am J Dermatopathol; 2007 Aug;29(4):359-64
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  • [Title] Cutaneous sebaceous neoplasms with a focal glandular pattern (seboapocrine lesions): a clinicopathological study of three cases.
  • Presented here are three cutaneous sebaceous tumors (one carcinoma and two sebaceomas), each demonstrating a focal glandular pattern representing apocrine differentiation.
  • The descriptive terms seboapocrine carcinoma or seboapocrine sebaceoma are proposed for such lesions.
  • These tumors may be viewed as rare histopathological variants of sebaceous carcinoma and sebaceoma, with a second type of differentiation along the lines of the folliculosebaceous-apocrine unit.
  • [MeSH-major] Apocrine Glands / pathology. Scalp / pathology. Sebaceous Gland Neoplasms / pathology. Sebum
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma / pathology. Cell Nucleolus / ultrastructure. Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Female. Follow-Up Studies. Humans. Hyperplasia. Male. Myocytes, Smooth Muscle / pathology

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  • (PMID = 17667168.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Kumar R: Clinicopathologic study of malignant eyelid tumours. Clin Exp Optom; 2010 Jul;93(4):224-7
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  • [Title] Clinicopathologic study of malignant eyelid tumours.
  • BACKGROUND: Early diagnosis of malignancy of eyelids can save the visual system from metastasis.
  • RESULTS: A total of 37 malignant eyelid tumours were seen.
  • Sebaceous gland carcinoma was the commonest (40.5 per cent) finding, followed by squamous cell carcinoma (27 per cent), basal cell carcinoma (24.3 per cent), basosquamous carcinoma (5.4 per cent) and malignant melanoma (2.7 per cent).
  • CONCLUSIONS: As the most common tumour in the region, sebaceous gland carcinoma might be due to geographical and environmental variations and requires immediate consultation and histopathologic diagnosis of lid lesions above 40 years of age for treatment strategies.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Carcinoma / epidemiology. Carcinoma / pathology. Carcinoma, Basosquamous / epidemiology. Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Child. Female. Humans. Incidence. Male. Middle Aged. Nepal / epidemiology. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / pathology. Sex Distribution. Young Adult

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  • (PMID = 20465547.001).
  • [ISSN] 1444-0938
  • [Journal-full-title] Clinical & experimental optometry
  • [ISO-abbreviation] Clin Exp Optom
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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83. Konstantinidis L, Scolozzi P, Hamédani M: Rehabilitation of orbital cavity after total orbital exenteration using oculofacial prostheses anchored by osseointegrated dental implants posed as a one-step surgical procedure. Klin Monbl Augenheilkd; 2006 May;223(5):400-4
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  • PATIENTS AND METHODS: A 72-year-old woman presenting a malignant melanoma of the right eyelids and a 77-year-old man presenting a sebaceous carcinoma of the left upper eyelid underwent a total exenteration followed by positioning of endosseous implants (Straumann system Dental implants) as an integrated one-step combined surgical procedure.

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  • (PMID = 16705515.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Dental Implants
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84. Shields JA, Shields CL: Sebaceous adenocarcinoma of the eyelid. Int Ophthalmol Clin; 2009;49(4):45-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous adenocarcinoma of the eyelid.
  • [MeSH-major] Adenocarcinoma, Sebaceous. Eyelid Neoplasms
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Diagnosis, Differential. Humans. Incidence. Prognosis. Risk Factors. United States / epidemiology

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  • (PMID = 20348857.001).
  • [ISSN] 1536-9617
  • [Journal-full-title] International ophthalmology clinics
  • [ISO-abbreviation] Int Ophthalmol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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85. Priyadarshini O, Biswas G, Biswas S, Padhi R, Rath S: Neoadjuvant chemotherapy in recurrent sebaceous carcinoma of eyelid with orbital invasion and regional lymphadenopathy. Ophthal Plast Reconstr Surg; 2010 Sep-Oct;26(5):366-8
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  • [Title] Neoadjuvant chemotherapy in recurrent sebaceous carcinoma of eyelid with orbital invasion and regional lymphadenopathy.
  • Histopathology showed it to be invasive sebaceous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Eyelid Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy. Orbital Neoplasms / drug therapy. Sebaceous Gland Neoplasms / drug therapy

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  • (PMID = 20856079.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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86. Ullah T, Gurwood AS, Myers MD: Ocular metastasis of cutaneous malignant melanoma. Optometry; 2009 Oct;80(10):572-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ocular metastasis of cutaneous malignant melanoma.
  • Patients at greatest risk often have disseminated metastases in the setting of advanced disease.
  • Because the prognosis for orbital metastatic disease is poor, emphasis must be placed on early detection and prevention.
  • Although cutaneous malignancies include basal cell carcinoma, squamous cell carcinoma, sebaceous cell carcinoma, and malignant melanoma, the majority of cases that result in metastasis, ocular morbidity, and mortality are from sebaceous cell carcinoma and malignant melanoma.
  • Her systemic medical history was significant for the diagnosis of a cutaneous malignant melanoma.
  • Magnetic resonance imaging confirmed the diagnosis of metastatic lesions involving structures of the left orbit ultimately causing reduced visual ability.
  • Although orbital metastasis is considered a terminal finding in these cases, timely diagnosis enables, while limited, the best options for management.

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  • (PMID = 19801341.001).
  • [ISSN] 1558-1527
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Gomes CC, Lacerda JC, Pimenta FJ, do Carmo MA, Gomez RS: Intraoral sebaceous carcinoma. Eur Arch Otorhinolaryngol; 2007 Jul;264(7):829-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoral sebaceous carcinoma.
  • Intraoral sebaceous carcinoma (SC) is a rare tumour in the oral cavity thought to arise from malignant transformation of oral sebaceous glands.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Mouth Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Radiography, Panoramic. Tomography, X-Ray Computed

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  • (PMID = 17285332.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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88. Berlin AL, Amin SP, Goldberg DJ: Extraocular sebaceous carcinoma treated with Mohs micrographic surgery: report of a case and review of literature. Dermatol Surg; 2008 Feb;34(2):254-7
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  • [Title] Extraocular sebaceous carcinoma treated with Mohs micrographic surgery: report of a case and review of literature.
  • [MeSH-major] Adenocarcinoma, Sebaceous / surgery. Mohs Surgery / methods. Sebaceous Gland Neoplasms / surgery

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  • (PMID = 18093187.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Yang HM, Cabral E, Dadras SS, Cassarino DS: Immunohistochemical expression of D2-40 in benign and malignant sebaceous tumors and comparison to basal and squamous cell carcinomas. Am J Dermatopathol; 2008 Dec;30(6):549-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of D2-40 in benign and malignant sebaceous tumors and comparison to basal and squamous cell carcinomas.
  • The diagnosis of sebaceous carcinoma presents an important challenge to both clinicians and pathologists, as many cases are initially misdiagnosed both clinically and histopathologically, potentially leading to adverse medical and legal outcomes.
  • The distinction of sebaceous carcinoma from benign sebaceous proliferations and other tumors is therefore of utmost importance, and immunohistochemistry may be useful in this differential.
  • We studied the expression of D2-40 (podoplanin) by immunohistochemistry to determine if it can aid in this differential diagnosis and to evaluate the possibility of lymphangiogenesis in sebaceous carcinoma.
  • A total of 36 cases of sebaceous lesions, including 16 sebaceous carcinomas, 7 sebaceous adenomas, 6 sebaceomas, and 7 cases of normal glands and sebaceous hyperplasia, and 17 cases of basal cell carcinoma and 10 cases of squamous cell carcinoma, were also examined.
  • We found no significant increase in tumor lymphangiogenesis by semiquantitative scoring of lymphovascular density per square millimeter of tumoral/peritumoral stroma in sebaceous carcinoma versus benign sebaceous proliferations.
  • However, D2-40 staining showed a different pattern in the benign tumors, which were positive only in the basaloid cells (most pronounced in sebaceoma), versus sebaceous carcinoma, which was either negative or focally positive in a haphazard pattern in most cases, although some cases of basaloid sebaceous carcinomas showed strong positivity.
  • We also found D2-40 to be only weakly and focally positive in basal cell carcinoma and weakly to moderately positive in squamous cell carcinoma, which showed increased staining with decreased differentiation.
  • Therefore, overall, D2-40 is, of limited diagnostic utility in sebaceous lesions but may be useful in distinguishing sebaceoma and basaloid sebaceous carcinoma from basal cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Antibodies, Monoclonal / metabolism. Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Glands / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / metabolism. Adenoma / pathology. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Case-Control Studies. Cell Proliferation. Diagnosis, Differential. Humans. Hyperplasia / diagnosis. Hyperplasia / metabolism. Hyperplasia / pathology

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  • (PMID = 19033927.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
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90. Reina RS, Parry E: Aggressive extraocular sebaceous carcinoma in a 52-year-old man. Dermatol Surg; 2006 Oct;32(10):1283-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive extraocular sebaceous carcinoma in a 52-year-old man.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 17034381.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Barnetson RA, Devlin L, Miller J, Farrington SM, Slater S, Drake AC, Campbell H, Dunlop MG, Porteous ME: Germline mutation prevalence in the base excision repair gene, MYH, in patients with endometrial cancer. Clin Genet; 2007 Dec;72(6):551-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient with the bi-allelic Y165C/G382D mutation also had a sebaceous carcinoma, a feature of Muir-Torre syndrome.
  • While not conclusive, this novel and interesting finding provides evidence that bi-allelic germline mutations in MYH may increase susceptibility to endometrial cancer.

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  • (PMID = 17956577.001).
  • [ISSN] 0009-9163
  • [Journal-full-title] Clinical genetics
  • [ISO-abbreviation] Clin. Genet.
  • [Language] eng
  • [Grant] United Kingdom / Chief Scientist Office / / CZB/4/449; United Kingdom / Medical Research Council / / MC/ U127527198
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA Primers; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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92. Swick JM, Lang PG Jr: Sebaceous gland carcinoma of the right flank. South Med J; 2009 Mar;102(3):312-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous gland carcinoma of the right flank.
  • Extraocular sebaceous gland carcinoma is a rare cutaneous malignancy which sometimes can grow rapidly.
  • There is no proven effective treatment for metastatic disease, but the tumor can be successfully treated by surgery if diagnosed early.
  • We report an 83-year-old gentleman with a rapidly growing sebaceous gland carcinoma of the right flank which was initially misdiagnosed as a vascular malformation.
  • By the time he was referred, he had widespread metastatic disease and was a candidate for palliative radiation only.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Adenocarcinoma, Sebaceous / pathology. Diagnostic Errors. Sebaceous Gland Neoplasms / diagnosis. Sebaceous Gland Neoplasms / pathology. Vascular Malformations / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Male. Neoplasm Metastasis. Palliative Care

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  • (PMID = 19204605.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Levy J, Cagnano E, Benharroch D, Monos T, Lifshitz T: Collision sebaceous and basal cell carcinomas of the eyelid. Ann Diagn Pathol; 2006 Jun;10(3):157-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collision sebaceous and basal cell carcinomas of the eyelid.
  • OBJECTIVE: To report a rare case of collision sebaceous and basal cell carcinomas of the eyelid.
  • Histopathology showed mixed sebaceous as well as basal cell carcinoma with uninvolved surgical margins.
  • CONCLUSION: Sebaceous and basal cell carcinomas can coexist in the eyelid within the same clinical lesion.
  • Because of the potential risk of metastasis of sebaceous carcinoma, close follow-up of the patients is advisable.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16730311.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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94. Greco M, Vitagliano T, Fiorillo MA, Atzeni M, Corona A, Ribuffo D: Rare malignant tumors of the scalp: a report of four cases, their treatment and a review of the literature. Eur Rev Med Pharmacol Sci; 2010 Nov;14(11):993-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rare malignant tumors of the scalp: a report of four cases, their treatment and a review of the literature.
  • BACKGROUND AND OBJECTIVES: Malignant tumors occurring in the scalp are not common and when asymptomatic or small in size, may be covered by hair and neglected by the patient, leading to a potential risk of delay in detection and resulting in poorer outcomes.
  • MATERIALS AND METHODS: In our Departments in the last five years more than 200 malignant tumors of the scalp have been operated on.
  • In this article we take into consideration four rare malignant tumours of the scalp taken from this study: a giant recurrent sebaceous carcinoma, a lung cancer metastatic lesion, a malignant melanoma and a breast cancer metastasis.
  • RESULTS: The four patients with rare malignant tumours have been operated with good results.
  • DISCUSSION: These four cases represent an important lesson for the plastic surgeon to learn: in the case of the presence of unusual, ulcerated/pigmented lesion of the scalp or in the case of alopecia we must consider the possibility of a tumour.

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  • (PMID = 21284349.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
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95. Kim HJ, Kim YB, Park JW, Oh WS, Kim EO, Lim BY, Kim DY: Recurrent sebaceous carcinoma in an African hedgehog (Atelerix albiventris). J Vet Med Sci; 2010 Jul;72(7):947-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent sebaceous carcinoma in an African hedgehog (Atelerix albiventris).
  • Based on these findings, a diagnosis of sebaceous carcinoma was made.
  • This is the first report of a sebaceous carcinoma in an African hedgehog.

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  • (PMID = 20215722.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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96. Dasgupta T, Wilson LD, Yu JB: A retrospective review of 1349 cases of sebaceous carcinoma. Cancer; 2009 Jan 1;115(1):158-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A retrospective review of 1349 cases of sebaceous carcinoma.
  • BACKGROUND: Sebaceous carcinoma is a rare and aggressive cutaneous carcinoma.
  • The median age at diagnosis was 73 years.
  • The most frequent site of disease was the eyelid (38.7%).
  • The overall population-matched rate of sebaceous carcinoma was highest in whites (2.03 cases per 1000,000; SE, 0.08) versus Asian/Pacific Islanders (1.07 per 1000,000; SE, 0.18; P=.0001) versus blacks (0.48 per 1,000,000; SE, 0.11; P<.0001).
  • CONCLUSIONS: The current results support the finding of a predominance of men among patients with sebaceous carcinoma, and no difference was observed in the prognosis for orbital and periorbital involvement.
  • This retrospective analysis also corroborated previous case reports of a higher incidence among patients with advanced age and the highest incidence for sites in the eyelid and skin of the face.
  • The results also established that Asian/Pacific Islander ancestry is not a risk factor for developing sebaceous carcinoma.
  • [MeSH-major] Head and Neck Neoplasms. Sebaceous Gland Neoplasms

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  • [Copyright] Copyright (c) 2008 American Cancer Society.
  • (PMID = 18988294.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Payne RJ, Lean MS, Greet TR: Third eyelid resection as a treatment for suspected squamous cell carcinoma in 24 horses. Vet Rec; 2009 Dec 26;165(25):740-3
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  • [Title] Third eyelid resection as a treatment for suspected squamous cell carcinoma in 24 horses.
  • Between October 2000 and January 2007, 24 horses were presented with suspected squamous cell carcinoma (SCC) of the third eyelid.
  • SCC was confirmed in 16 of these 21 cases, three cases were diagnosed histologically as lymphoid hyperplasia, one as a mast cell tumour and one as a sebaceous gland adenocarcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / veterinary. Eyelid Neoplasms / veterinary. Horse Diseases / surgery. Nictitating Membrane

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  • (PMID = 20023277.001).
  • [ISSN] 2042-7670
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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98. Murakami A, Kawachi K, Sasaki T, Ishikawa T, Nagashima Y, Nozawa A: Sebaceous carcinoma of the breast. Pathol Int; 2009 Mar;59(3):188-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the breast.
  • Sebaceous carcinoma (SC) of the breast is a rare malignant tumor and only nine cases, including the present one, have been reported in the English-language literature.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Breast Neoplasms / pathology. Receptors, Androgen / metabolism. Sebaceous Gland Neoplasms / pathology


99. Xiao J, Song R: [Parotid gland sebaceous adenocarcinoma: a case report]. Zhonghua Zhong Liu Za Zhi; 2005 May;27(5):298
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Parotid gland sebaceous adenocarcinoma: a case report].
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Parotid Neoplasms / pathology

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  • (PMID = 15996326.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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100. Innocenzi D, Balzani A, Lupi F, Panetta C, Skroza N, Cantoresi F, Schwartz RA, Calvieri S: Morpheaform extra-ocular sebaceous carcinoma. J Surg Oncol; 2005 Dec 15;92(4):344-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morpheaform extra-ocular sebaceous carcinoma.
  • BACKGROUND: Sebaceous carcinoma is an unusual, aggressive, malignant tumor derived from the epithelium of sebaceous glands.
  • A significant number of extra-ocular sebaceous carcinomas have been associated with metastases and high mortality rate.
  • METHODS AND RESULTS: We reviewed the literature in the context of our report of a 68-year-old woman who had a morpheaform plaque of the upper lip of 15 years duration, extending into the left naso-genal groove, which histologically also showed marked stromal fibrosis.
  • CONCLUSIONS: This patient is unusual in clinical and histologic pattern, as a morpheaform appearance has only been described previously in only one sebaceous carcinoma.
  • In addition, no metastatic disease 15 years after tumor onset is a fortunate and remarkable feature.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Lip / pathology. Scleroderma, Localized / pathology. Sebaceous Gland Neoplasms / pathology

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  • [Copyright] 2005 Wiley-Liss, Inc.
  • (PMID = 16299801.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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