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1. Sharifzadeh S, Modjtahedi H, Jedi Tehrani M, Bayat A, Ghaderi A: Production and characterization of a monoclonal antibody against an antigen on the surface of non-small cell carcinoma of the lung. Iran J Immunol; 2007 Dec;4(4):206-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Production and characterization of a monoclonal antibody against an antigen on the surface of non-small cell carcinoma of the lung.
  • BACKGROUND: Lung carcinoma is a multiple type cancer comprising of small cell and non-small cell carcinomas (NSCLC).
  • For therapeutic and diagnostic purposes, serum monoclonal antibodies have been produced against lung cancer.
  • METHODS: A murine monoclonal antibody (ME3D11) reactive with human NSCLC was selected after immunization of BALB/c mice with a human large cell carcinoma with neuroendocrine differentiation, and was tested by immunofloursence staining and Western blot analysis.
  • This antigen is expressed on the cell surface of all NSCLC and a few carcinoma cell lines.
  • CONCLUSIONS: High degree of binding of this monoclonal antibody to NSCLC and some other carcinoma cells warrants further studies on its potential use in diagnosis and therapy of cancer by conjugation to drugs, toxins or radionuclides.
  • [MeSH-major] Antibodies, Monoclonal / immunology. Antibodies, Monoclonal / metabolism. Antigens, Neoplasm / immunology. Carcinoma, Non-Small-Cell Lung / immunology. Lung Neoplasms / immunology. Membrane Proteins / immunology
  • [MeSH-minor] Animals. Cell Line. Cercopithecus aethiops. Humans. Mice. Mice, Inbred BALB C

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  • (PMID = 18057578.001).
  • [ISSN] 1735-1383
  • [Journal-full-title] Iranian journal of immunology : IJI
  • [ISO-abbreviation] Iran J Immunol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Iran
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Membrane Proteins
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2. Molenaar JP, Baten A, Blokx WA, Hoogendam A: Development of carcinoid tumour in hormonally treated adenocarcinoma of the prostate. Eur Urol; 2009 Nov;56(5):874-7; quiz 876
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  • [Title] Development of carcinoid tumour in hormonally treated adenocarcinoma of the prostate.
  • We present the case of an 81-yr-old man with a prostatic adenocarcinoma and a metastatic carcinoid.
  • Simultaneous occurrence of hormonally treated adenocarcinoma of the prostate and a carcinoid has been described before.
  • The pathogenesis of this coincidence is largely unclear; however, androgen deprivation therapy might play a key role in neuroendocrine differentiation of adenocarcinoma cells.
  • [MeSH-major] Adenocarcinoma / drug therapy. Androgen Antagonists / therapeutic use. Anilides / therapeutic use. Antineoplastic Agents, Hormonal / therapeutic use. Carcinoid Tumor / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary. Nitriles / therapeutic use. Prostatic Neoplasms / drug therapy. Tosyl Compounds / therapeutic use
  • [MeSH-minor] Aged, 80 and over. Biopsy. Humans. Male. Malignant Carcinoid Syndrome / drug therapy. Positron-Emission Tomography. Somatostatin / analogs & derivatives. Somatostatin / therapeutic use

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  • (PMID = 19171417.001).
  • [ISSN] 1873-7560
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Androgen Antagonists; 0 / Anilides; 0 / Antineoplastic Agents, Hormonal; 0 / Nitriles; 0 / Tosyl Compounds; 51110-01-1 / Somatostatin; A0Z3NAU9DP / bicalutamide
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3. Tang Y, Wang L, Goloubeva O, Khan MA, Lee D, Hussain A: The relationship of neuroendocrine carcinomas to anti-tumor therapies in TRAMP mice. Prostate; 2009 Dec 01;69(16):1763-73
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  • [Title] The relationship of neuroendocrine carcinomas to anti-tumor therapies in TRAMP mice.
  • BACKGROUND: Neuroendocrine differentiation and neuroendocrine carcinoma (NEC) have been linked to androgen deprivation in prostate cancers.
  • No previous study has directly connected neuroendocrine phenotypes to chemotherapy.
  • METHODS: Using the transgenic adenocarcinoma of mouse prostate (TRAMP) model, we studied tumor progression after hormone ablation (castration) and/or chemotherapy (docetaxel), and analyzed the incidence of NEC as a function of the anti-tumor therapies.
  • RESULTS: Although all animals developed prostate cancer, no NEC was found in control mice.
  • The NEC-bearing mice had smaller tumors in their prostates and lived longer than mice with adenocarcinoma (ADC-only).
  • However, NEC tumors had a higher proliferative index and greater potential for metastasis and drug-resistance, as evidenced by significantly higher expression levels of PCNA, S100A4, and Pgp, but lower levels of E-cadherin.
  • Although NEC and ADC differ in their expressions of many proteins, a high level of SV40 T-antigen in both tumor types suggest a common progenitor..
  • [MeSH-major] Adenocarcinoma / drug therapy. Androgen Antagonists / adverse effects. Antineoplastic Agents / adverse effects. Carcinoma, Neuroendocrine / chemically induced. Prostatic Neoplasms / drug therapy. Taxoids / adverse effects
  • [MeSH-minor] ATP Binding Cassette Transporter, Sub-Family G, Member 2. ATP-Binding Cassette Transporters / metabolism. ATP-Binding Cassette, Sub-Family B, Member 1 / metabolism. Animals. Cell Proliferation. Drug Therapy, Combination. Incidence. Male. Mice. Mice, Transgenic. Neoplasm Proteins / metabolism. Survival Analysis

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  • [Copyright] Copyright 2009 Wiley-Liss, Inc.
  • (PMID = 19691128.001).
  • [ISSN] 1097-0045
  • [Journal-full-title] The Prostate
  • [ISO-abbreviation] Prostate
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / ATP Binding Cassette Transporter, Sub-Family G, Member 2; 0 / ATP-Binding Cassette Transporters; 0 / ATP-Binding Cassette, Sub-Family B, Member 1; 0 / Androgen Antagonists; 0 / Antineoplastic Agents; 0 / Neoplasm Proteins; 0 / Taxoids; 15H5577CQD / docetaxel
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4. Kitamoto K, Hayashi T, Tamada S, Ezaki K, Kawashima H, Sugimura K, Nakatani T: [Neuroendocrine differentiation in adenocarcinoma of prostate during combined androgen blockade therapy: a case report]. Hinyokika Kiyo; 2005 Jan;51(1):33-5
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  • [Title] [Neuroendocrine differentiation in adenocarcinoma of prostate during combined androgen blockade therapy: a case report].
  • Prostatic neuroendocrine (NE) carcinoma is a rare disease with a poor prognosis because of its rapid progression and the androgen-independent characteristic, for which no successful therapy is available presently.
  • We report a case of NE differentiated prostate cancer, which was diagnosed as adenocarcinoma initially and progressed with NE differentiation during the combined androgen blockade therapy.
  • [MeSH-major] Adenocarcinoma / pathology. Androgen Antagonists / therapeutic use. Carcinoma, Neuroendocrine / pathology. Cell Transformation, Neoplastic / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Drug Resistance, Neoplasm. Humans. Magnetic Resonance Imaging. Male. Neoplasm Staging

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  • (PMID = 15732339.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Androgen Antagonists
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5. Zufferey L, Roques B, Fl├ęchon A, Droz JP: [Study of the hormone-refractory prostate cancer clinical practice in an anti-cancer center]. Bull Cancer; 2001 Dec;88(12):1213-21
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  • [Transliterated title] La pratique clinique du cancer de la prostate horomonor├ęsistant dans un centre de lutte contre le cancer.
  • Objective and palliative effect of chemotherapy is marked for weekly doxorubicin, prednisone with mitoxantrone and etoposide associated with platin-salts for prostatic carcinoma with neuroendocrine differentiation.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Bone Neoplasms / secondary. Brain Neoplasms / secondary. Drug Resistance, Neoplasm. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Phosphopyruvate Hydratase / blood. Prospective Studies. Prostate-Specific Antigen / blood






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