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1. Chebib I, Beck PL, Church NG, Medlicott SA: Gastric pouch adenocarcinoma and tubular adenoma of the pylorus: a field effect of dysplasia following bariatric surgery. Obes Surg; 2007 Jun;17(6):843-6
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  • [Title] Gastric pouch adenocarcinoma and tubular adenoma of the pylorus: a field effect of dysplasia following bariatric surgery.
  • There are reports of gastric carcinoma following bariatric surgery, but it is unclear if these procedures predispose to malignancy.
  • Histology confirmed an intestinal type of gastric adenocarcinoma arising in a background of H. pylori-negative gastritis with atrophy, foveolar hyperplasia and intestinal metaplasia.
  • An incidental tubular adenoma at the pylorus was also identified.
  • The pathogenesis of gastric pouch carcinoma is discussed.
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Gastroplasty. Postoperative Complications. Stomach Neoplasms / etiology

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  • [ErratumIn] Obes Surg. 2007 Jul;17(7):996
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  • (PMID = 17879590.001).
  • [ISSN] 0960-8923
  • [Journal-full-title] Obesity surgery
  • [ISO-abbreviation] Obes Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Erşahin C, Huang M, Potkul RK, Hammadeh R, Salhadar A: Mesonephric adenocarcinoma of the vagina with a 3-year follow-up. Gynecol Oncol; 2005 Dec;99(3):757-60
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  • [Title] Mesonephric adenocarcinoma of the vagina with a 3-year follow-up.
  • BACKGROUND: Mesonephric adenocarcinoma of the vagina is exceedingly rare, with only one well-documented case in the literature.
  • Little is known regarding clinical presentation, pathological characteristics, therapy, or prognosis of the vaginal mesonephric adenocarcinoma.
  • The tumor was an adenocarcinoma with ductal and tubular pattern arising in a background of mesonephric remnants.
  • CONCLUSION: We report the second case of mesonephric adenocarcinoma of the vagina with metastasis to the right fallopian tube and to one paravaginal lymph node.
  • [MeSH-major] Adenocarcinoma / pathology. Mesonephroma / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 16137744.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Fujita M, Fujimori T, Chiba T: [The definition of Barrett's esophagus]. Nihon Rinsho; 2005 Aug;63(8):1325-32
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  • They proposed that BE was a chance in the esophageal epithelium of any length that can be recognized at endoscopy, and confirmed to have intestinal metaplasia by biopsy of the tubular esophagus and excludes intestinal metaplasia of the cardia.
  • Histologically, BE has double muscularis mucosae, and contains a mixture cell types; gastric-fundic type epithelium, junctional type epithelium, and specialized columnar epithelium (SCE).
  • Especially SCE is distinctive features of BE, available for diagnosis.
  • On the other hand, BE is premalignant condition for the adenocarcinoma of the esophagus, therefore the features of the BE are researched to prevent and find out earlier development of adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / etiology. Adenocarcinoma / prevention & control. Esophageal Neoplasms / etiology. Esophageal Neoplasms / prevention & control. Esophagoscopy. Gastroesophageal Reflux / complications. Humans

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  • (PMID = 16101217.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 21
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4. Ida S, Ohmuraya M, Hirota M, Ozaki N, Hiramatsu S, Uehara H, Takamori H, Araki K, Baba H, Yamamura K: Chronic pancreatitis in mice by treatment with choline-deficient ethionine-supplemented diet. Exp Anim; 2010;59(4):421-9
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  • Although chronic pancreatitis is a risk factor for pancreatic ductal adenocarcinoma (PDA), the relationship between chronic pancreatitis and PDA remains obscure.
  • Histological evaluation revealed that chronic pancreatitis, characterized by acinar atrophy, fibrosis and well-developed tubular complexes (TCs), was observed after 24 weeks of CDE diet treatment.

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  • (PMID = 20660988.001).
  • [ISSN] 1881-7122
  • [Journal-full-title] Experimental animals
  • [ISO-abbreviation] Exp. Anim.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Glycoproteins; 0 / Prostatic Secretory Proteins; 0 / Spink3 protein, mouse; 0 / Transforming Growth Factor alpha; EC 2.7.10.1 / EGFR protein, mouse; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.2.1.- / Amylases; EC 3.6.5.2 / ras Proteins; WX1BN24WZT / Ethionine
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5. Mizushima T, Sugiura T, Hori S, Ito T, Mizuno H, Hoki M, Souma Y, Kainuma S, Yamanaka H, Ozawa H, Kanou T, Nakamori Y, Iwase K: [A case of postoperative liver metastasis from bile duct carcinoma responding to transarterial chemoembolization]. Gan To Kagaku Ryoho; 2006 Feb;33(2):263-5
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  • [Title] [A case of postoperative liver metastasis from bile duct carcinoma responding to transarterial chemoembolization].
  • A 77-year-old man underwent pylorus-preserving pancreatoduodenectomy for bile duct carcinoma in October 2000.
  • Histological diagnosis was moderately-differentiated tubular adenocarcinoma, pT 2 (ss, pHinf 0, pPanc 1, pPV 0, pA 0), pN 0, and final Stage II.
  • Transarterial chemoembolization with 5-FU, epirubicin, mitomycin C and superabsorbent polymer microsphere was initiated under the diagnosis of liver metastasis.
  • [MeSH-major] Adenocarcinoma / surgery. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Bile Duct Neoplasms / surgery. Chemoembolization, Therapeutic. Liver Neoplasms / secondary. Liver Neoplasms / therapy

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  • (PMID = 16484870.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Polymers; 3Z8479ZZ5X / Epirubicin; 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
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6. Gazvoda B, Juvan R, Zupanic-Pajnic I, Repse S, Ferlan-Marolt K, Balazic J, Komel R: Genetic changes in Slovenian patients with gastric adenocarcinoma evaluated in terms of microsatellite DNA. Eur J Gastroenterol Hepatol; 2007 Dec;19(12):1082-9
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  • [Title] Genetic changes in Slovenian patients with gastric adenocarcinoma evaluated in terms of microsatellite DNA.
  • OBJECTIVES: Adenocarcinoma of the stomach is a relatively frequent malignant disease in Slovenia.
  • We investigated the frequency of microsatellite instability (MSI) and loss of heterozygosity (LOH) in gastric carcinomas from the Slovenian population to determine their prognostic significance.
  • LOH-N status was associated with diagnosis at higher TNM status (0.074) and infiltrative growth (P=0.006).
  • MSI-H was associated with higher age at diagnosis (r=0.24; P=0.04), antral location (r=0.252; P=0.04), intestinal type (P=0.044), expansive growth (P=0.001), tubular type (0.014), better differentiation (P=0.01), less nodal involvement (0.006) and better survival (P=0.022).
  • [MeSH-major] Adenocarcinoma / genetics. Loss of Heterozygosity. Microsatellite Instability. Stomach Neoplasms / genetics

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  • [CommentIn] Eur J Gastroenterol Hepatol. 2007 Dec;19(12):1038-40 [17998824.001]
  • (PMID = 17998833.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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7. MacLennan GT, Bostwick DG: Tubulocystic carcinoma, mucinous tubular and spindle cell carcinoma, and other recently described rare renal tumors. Clin Lab Med; 2005 Jun;25(2):393-416
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  • [Title] Tubulocystic carcinoma, mucinous tubular and spindle cell carcinoma, and other recently described rare renal tumors.
  • Tubulocystic carcinoma needs to be studied and characterized more fully.
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Angiomyolipoma / pathology. Humans. Kidney Tubules, Collecting / pathology. Neoplasms, Glandular and Epithelial / pathology. Neuroectodermal Tumors, Primitive / pathology. Sarcoma, Synovial / pathology


8. Nakamura H, Taniguchi Y, Miwa K, Adachi Y, Fujioka S, Kamihira S, Ishiguro S, Horie Y: Primary adenocarcinoma of the trachea resected using percutaneous cardiopulmonary support (PCPS). Ann Thorac Cardiovasc Surg; 2007 Oct;13(5):338-40
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  • [Title] Primary adenocarcinoma of the trachea resected using percutaneous cardiopulmonary support (PCPS).
  • We encountered one very rare case of primary adenocarcinoma of the trachea.
  • After establishing artificial respiration, a tracheal tubular resection was immediately performed using percutaneous cardiopulmonary support (PCPS).
  • A postoperative pathological examination led to the patient being diagnosed with primary adenocarcinoma of the trachea, and she was treated with adjuvant chemotherapy.
  • [MeSH-major] Adenocarcinoma / surgery. Cardiopulmonary Bypass / methods. Tracheal Neoplasms / surgery
  • [MeSH-minor] Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Respiration, Artificial. Tomography, X-Ray Computed

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  • (PMID = 17954992.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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9. Romano G, Cocchiara G, Maniaci S, Buscemi G, Calderone F, Gioè FP, Romano M: [The role of colonoscopy in patient follow-up after surgery for colorectal cancer. A retrospective study and review of the literature]. G Chir; 2007 Oct;28(10):399-402
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  • From October 2002 to January 2006, 864 patients had undergone colonoscopy and 68 were treated surgically for colorectal adenocarcinoma.
  • In addition, in 11 cases, there were 3 right colon adenomatous polyps, 2 transverse colon polyps (one villous and the other tubular), 5 descending colon polyps (three tubular and two villous) and 1 tubulo-villous polyp of the rectum.
  • An examination of the data resulting from our own 68 cases shows that, in spite of the fact that no local disease relapse or metachronous neoplasia was observed, the identification of 11 polyps would suggest that the use of colonoscopy in such patients might be the gold standard for early diagnosis of recurrences and new polyps.
  • [MeSH-major] Adenocarcinoma / surgery. Colonoscopy. Colorectal Neoplasms / surgery. Neoplasm Recurrence, Local / prevention & control. Neoplasms, Second Primary / prevention & control
  • [MeSH-minor] Aged. Colonic Polyps / diagnosis. Female. Follow-Up Studies. Humans. Male. Middle Aged. Predictive Value of Tests. Retrospective Studies

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  • (PMID = 17915057.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 55
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10. Hansel DE, Nadasdy T, Epstein JI: Fibromyxoid nephrogenic adenoma: a newly recognized variant mimicking mucinous adenocarcinoma. Am J Surg Pathol; 2007 Aug;31(8):1231-7
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  • [Title] Fibromyxoid nephrogenic adenoma: a newly recognized variant mimicking mucinous adenocarcinoma.
  • Nephrogenic adenomas demonstrate a variety of morphologic patterns that may occasionally be confused with malignant processes, including urothelial and prostatic carcinoma.
  • In this series, we describe 8 cases of nephrogenic adenoma that contain an admixture of the classic tubular form of nephrogenic adenoma and an unusual spindled and fibromyxoid form of nephrogenic adenoma that closely mimics infiltrating carcinoma.
  • In all cases, the classic tubular form of nephrogenic adenoma composed only a small proportion of the lesion, whereas the remainder consisted of compressed spindled cells within a fibromyxoid background, with only rare tubular and cordlike structures.
  • All 8 patients were elderly men who had a prior or concurrent history of acinar prostate cancer (n=4), combined acinar prostate and urothelial carcinoma (n=1), urothelial-type adenocarcinoma of the prostate (n=1), bladder urothelial carcinoma (n=1), or no prior reported prostatic or urothelial abnormalities (n=1).
  • Awareness of this entity and the use of ancillary techniques can aid in the diagnosis of this unusual form of nephrogenic adenoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenoma / pathology. Fibroma / pathology. Urologic Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Male. Middle Aged. Mucins / analysis. Neoplasms, Multiple Primary. Urothelium / chemistry. Urothelium / pathology

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  • (PMID = 17667548.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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11. Jukkola-Vuorinen A, Rahko E, Vuopala KS, Desmond R, Lehenkari PP, Harris KW, Selander KS: Toll-like receptor-9 expression is inversely correlated with estrogen receptor status in breast cancer. J Innate Immun; 2009;1(1):59-68
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  • We previously demonstrated TLR9 expression in human breast cancer cell lines and showed that TLR9 ligands stimulate their in vitro invasion.
  • The highest TLR9 expression was detected in the mucinous and the lowest in the tubular breast cancers (p = 0.034).
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Biomarkers, Tumor / metabolism. Breast Neoplasms / pathology. Receptors, Estrogen / metabolism. Toll-Like Receptor 9 / metabolism

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 20375566.001).
  • [ISSN] 1662-8128
  • [Journal-full-title] Journal of innate immunity
  • [ISO-abbreviation] J Innate Immun
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Estrogen; 0 / TLR9 protein, human; 0 / Toll-Like Receptor 9; 4TI98Z838E / Estradiol
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12. Marchiò C, Sapino A, Arisio R, Bussolati G: A new vision of tubular and tubulo-lobular carcinomas of the breast, as revealed by 3-D modelling. Histopathology; 2006 Apr;48(5):556-62
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  • [Title] A new vision of tubular and tubulo-lobular carcinomas of the breast, as revealed by 3-D modelling.
  • AIMS: To reveal architectural structure and growth patterns of tubular carcinomas (TC) and tubulo-lobular carcinomas (TLC) of the breast.
  • In TLC the structure was similar, but the connecting single-cell files were usually longer.
  • [MeSH-major] Adenocarcinoma / pathology. Breast Neoplasms / pathology. Carcinoma, Lobular / pathology. Imaging, Three-Dimensional / methods. Models, Biological

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  • (PMID = 16623781.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 68238-35-7 / Keratins
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13. Sokolova IA, Matsko DE, Hes O, Michal M: [Mucinous tubular and spindle-cell carcinoma of the kidney]. Arkh Patol; 2006 Jul-Aug;68(4):14-5
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  • [Title] [Mucinous tubular and spindle-cell carcinoma of the kidney].
  • 4 cases (2 males and 2 females) of mucinous tubular and spindle-cell carcinoma of the kidney were studied.
  • Microscopically, this tumor comprised two major cell populations.
  • Only one tumor had both cell components.
  • Mucinous tubular and spindle-cell carcinoma of the kidney should be differentiated from angiomyolipoma with the preponderance of a leiomyomatous component, renal smooth muscle neoplasms, metanephrotic adenoma, and renal cell carcinoma with sarcomatoid differentiation.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 16986488.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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14. Fedko MG, Scow JS, Shah SS, Reynolds C, Degnim AC, Jakub JW, Boughey JC: Pure tubular carcinoma and axillary nodal metastases. Ann Surg Oncol; 2010 Oct;17 Suppl 3:338-42
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  • [Title] Pure tubular carcinoma and axillary nodal metastases.
  • BACKGROUND: Pure tubular carcinoma of the breast is a rare subtype with a low incidence of axillary lymph node metastases.
  • The aim of this study was to determine the frequency of axillary lymph node metastasis in patients with pure tubular carcinoma.
  • METHODS: We identified patients diagnosed with tubular carcinoma from 1987 to 2009 from our institution's tumor registry.
  • Pathology slides were reviewed, and pure tubular carcinoma was defined as ≥ 90% tubule formation, low nuclear grade, and rare to no mitoses.
  • RESULTS: We identified 105 cases of pure tubular carcinoma of the breast in 103 patients.
  • CONCLUSIONS: Axillary lymph node metastases are not common in small pure tubular carcinomas.
  • Nodal staging may be omitted in small pure tubular carcinomas.
  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / pathology

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  • (PMID = 20853056.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Svara T, Gombac M, Vrecl M, Juntes P, Kostanjsek R, Pogacnik A, Pogacnik M: Enzootic nasal adenocarcinoma of sheep in Slovenia. J Vet Med A Physiol Pathol Clin Med; 2006 Feb;53(1):26-9
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  • [Title] Enzootic nasal adenocarcinoma of sheep in Slovenia.
  • SUMMARY Clinicopathological and electron microscopical findings of eight cases of enzootic nasal adenocarcinoma of sheep, diagnosed solely in one big flock in Slovenia between years 2001 and 2003 are described.
  • All tumours were classified as adenocarcinomas by histopathological examination and they displayed either a combination of tubular and papillary growth or less often solely tubular proliferation.
  • [MeSH-major] Adenocarcinoma / veterinary. Nose Neoplasms / veterinary. Sheep Diseases / pathology

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  • (PMID = 16411905.001).
  • [ISSN] 0931-184X
  • [Journal-full-title] Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
  • [ISO-abbreviation] J Vet Med A Physiol Pathol Clin Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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16. Labaye J, Sarret D, Duvic C, Hérody M, Didelot F, Nédélec G, Noël LH: Renal toxicity of oxaliplatin. Nephrol Dial Transplant; 2005 Jun;20(6):1275-6
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  • [MeSH-major] Acute Kidney Injury / chemically induced. Adenocarcinoma / drug therapy. Antineoplastic Agents / adverse effects. Organoplatinum Compounds / adverse effects. Ovarian Neoplasms / drug therapy
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols. Female. Humans. Kidney Tubular Necrosis, Acute / chemically induced. Kidney Tubular Necrosis, Acute / pathology

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  • (PMID = 15827046.001).
  • [ISSN] 0931-0509
  • [Journal-full-title] Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • [ISO-abbreviation] Nephrol. Dial. Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin
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17. Ghidirim G, Mişin I, Istrate V, Cazacu S: Endoscopic papillectomy into the treatment of neoplastic lesions of vater papilla. Curr Health Sci J; 2009 Apr;35(2):92-7
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  • The frequency of malignant adenomas is 15-30%.
  • Pathology examination has show: tubulo-villous adenoma (5 patients); villous adenoma (4 patients), tubular adenoma (2 cases), adenocarcinoma (one case).

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  • (PMID = 24778815.001).
  • [ISSN] 2067-0656
  • [Journal-full-title] Current health sciences journal
  • [ISO-abbreviation] Curr Health Sci J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Other-IDs] NLM/ PMC3945241
  • [Keywords] NOTNLM ; Vater papilla / ampullary adenoma / bleeding / endoscopic papillectomy / pancreatitis / sphyncterotomy
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18. Fiducia G, Gandolfo L, Bosco V: [Protruding isolated rectal and anal neoplastic polyps removed by local transanal excision: our experience with 16 cases]. Chir Ital; 2008 Mar-Apr;60(2):227-32
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  • Histologically, 2 were tubular adenomas without atypia (12.5%), 3 were tubulo-villous adenomas with moderate atypia (18.75%), 8 were tubulo-villous adenomas (50%) with severe atypia, 2 were tubulo-villous adenomas with locally invasive foci of adenocarcinoma (12.5%), and 1 case was a pT1 cloacogenic carcinoma (6.25%).

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  • (PMID = 18689170.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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19. Hsu PI, Huang MS, Chen HC, Hsu PN, Lai TC, Wang JL, Lo GH, Lai KH, Tseng CJ, Hsiao M: The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer. J Surg Oncol; 2008 Jun 1;97(7):609-14
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  • However, the ANXA7 expression in different histological subtypes of gastric adenocarcinomas and its correlation with invasive potentials has not been elucidated.
  • METHODS: Immunohistochemical staining of ANXA7 for 84 primary gastric adenocarcinomas was performed, and data was correlated with clinicopathological parameters of patients.
  • Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively.
  • CONCLUSIONS: A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed.
  • [MeSH-major] Adenocarcinoma / genetics. Annexin A7 / biosynthesis. Cell Differentiation / genetics. Stomach Neoplasms / genetics

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  • (PMID = 18449914.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Annexin A7
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20. Oh DK, Kim SH, Choi SH, Jang KT: Intraductal tubular carcinoma of the pancreas: a case report with the imaging findings. Korean J Radiol; 2008 Sep-Oct;9(5):473-6
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  • [Title] Intraductal tubular carcinoma of the pancreas: a case report with the imaging findings.
  • We describe here a case of intraductal tubular carcinoma of the main pancreatic duct.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Staging. Tomography, X-Ray Computed

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  • [Cites] Am J Surg Pathol. 2004 Feb;28(2):233-8 [15043313.001]
  • [Cites] Pancreas. 2004 Aug;29(2):116-22 [15257103.001]
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  • (PMID = 18838860.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627216
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21. Anwar M, Koriyama C, Naveed IA, Hamid S, Ahmad M, Itoh T, Minakami Y, Eizuru Y, Akiba S: Epstein-barr virus detection in tumors of upper gastrointestinal tract. An in situ hybridization study in Pakistan. J Exp Clin Cancer Res; 2005 Sep;24(3):379-85
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  • To examine the potential role of Epstein-Barr virus (EBV) in the carcinogenesis of upper gastrointestinal tract, we conducted an in situ hybridization assay for EBV-encoded small RNA (EBER) expression in the tumors of 56 oral and 50 esophageal squamous cell carcinoma (SCC) cases, and 52 stomach adenocarcinoma cases diagnosed in the King Edward Medical College and Allama Iqbal Medical College Lahore, Pakistan between 1996-2002.
  • Only one out of the 52 gastric adenocarcinoma cases (1.9%) was positive for EBER expression, and this frequency was relatively low as compared to cases reported worldwide.
  • The case was a 42 year-old male patient and histologically classified as moderately differentiated tubular adenocarcinoma.
  • In conclusion, the frequency of EBV-associated gastric carcinoma was relatively low in Pakistan.
  • [MeSH-major] Adenocarcinoma / virology. Carcinoma, Squamous Cell / virology. Gastrointestinal Neoplasms / virology. Herpesvirus 4, Human / isolation & purification

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  • (PMID = 16270524.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / DNA Probes
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22. Sargan I, Motoc A, Vaida MA, Bolintineanu S, Vîscu S: Anatomic and pathological aspects in the pathology of malignant gastric tumors. Rom J Morphol Embryol; 2006;47(2):163-8
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  • [Title] Anatomic and pathological aspects in the pathology of malignant gastric tumors.
  • Efforts in perfecting the methods of early diagnosis, in trying to assess premalignant conditions, and in properly staging malignant tumors are still in trend.
  • Most gastric carcinomas are adenocarcinoma, 404 (90%) cases--could be classified as follows: 167 cases of tubular adenocarcinoma; 39 cases of papillary adenocarcinoma; 24 cases of mucinous or colloid adenocarcinoma; 141 "signet ring"-cell carcinoma; 33 cases of undifferentiated carcinoma.
  • Attention should be given to precancerous conditions; there was a large number of premalignant or potentially malignant gastric damage: atrophic chronic gastritis (54 cases), intestinal metaplasia (104 cases), and gastric dysplasia (104 cases).
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Biopsy. Female. Helicobacter Infections / pathology. Helicobacter pylori. Humans. Male. Retrospective Studies

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  • (PMID = 17106525.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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23. Kuroda N, Tamura M, Hes O, Michal M, Kawada C, Shuin T, Lee GH: Renal cell carcinoma with extensive clear cell change sharing characteristics of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma. Pathol Int; 2009 Sep;59(9):687-8
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  • [Title] Renal cell carcinoma with extensive clear cell change sharing characteristics of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Carcinoma / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology


24. Triolo O, Antico F, Mancuso A, Salimbeni V, Nicotina PA: Postmenopausal bleeding and vaginal nodules as the first presenting sign of adenocarcinoma of the gallbladder. Eur J Gynaecol Oncol; 2005;26(5):543-4
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  • [Title] Postmenopausal bleeding and vaginal nodules as the first presenting sign of adenocarcinoma of the gallbladder.
  • On biopsy, light microscopy suggested that the lesions might be metastatic foci from an extragenital cancer, with a prevalent tubular growth pattern.
  • Parallel immunohistochemical reactions revealed a diffuse, strong CA 19-9 positivity in both the cell membrane and cytoplasm.
  • A mass in the gallbladder fossa was then detected by computed tomography and a primary gallbladder adenocarcinoma was confirmed on ultrasound-guided biopsy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Gallbladder Neoplasms / diagnosis. Uterine Neoplasms / diagnosis. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Fatal Outcome. Female. Humans. Neoplasm Metastasis. Postmenopause. Uterine Hemorrhage / etiology

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  • (PMID = 16285575.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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25. Collins LC: Flat Epithelial Atypia of the Breast. Surg Pathol Clin; 2009 Jun;2(2):263-72
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  • FEA commonly coexists with well-developed examples of atypical ductal hyperplasia, low-grade ductal carcinoma in situ, lobular neoplasia, and tubular carcinoma.
  • These findings and those of recent genetic studies suggest that FEA is a neoplastic lesion that may represent a precursor to or the earliest morphologic manifestation of ductal carcinoma in situ.

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  • [Copyright] Copyright © 2009 Elsevier Inc. All rights reserved.
  • (PMID = 26838322.001).
  • [ISSN] 1875-9181
  • [Journal-full-title] Surgical pathology clinics
  • [ISO-abbreviation] Surg Pathol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Breast / Columnar cell / Flat epithelial atypia / Low-grade neoplasia
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26. Yamaguchi H, Shimizu M, Ban S, Koyama I, Hatori T, Fujita I, Yamamoto M, Kawamura S, Kobayashi M, Ishida K, Morikawa T, Motoi F, Unno M, Kanno A, Satoh K, Shimosegawa T, Orikasa H, Watanabe T, Nishimura K, Ebihara Y, Koike N, Furukawa T: Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol; 2009 Aug;33(8):1164-72
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  • All the features of ITPN were distinct from those of other known intraductal pancreatic neoplasms, including pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and the intraductal variant of acinar cell carcinoma.
  • Intraductal tubular carcinomas showed several features that were similar to those of ITPN, except for the tubulopapillary growth pattern.
  • In conclusion, ITPNs can be considered to represent a new disease entity encompassing intraductal tubular carcinoma as a morphologic variant.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / genetics. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / genetics. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology


27. Nakanuma Y, Zen Y, Harada K, Ikeda H, Sato Y, Uehara T, Sasaki M: Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach. J Hepatobiliary Pancreat Sci; 2010 May;17(3):211-22
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  • Decreased expression of membranous beta-catenin and E-cadherin and aberrant expression of MMP-7 and -9 and of MUC1 are related to invasion of IPNB with tubular adenocarcinoma, whereas MUC2 is involved in the invasion of IPNB with mucinous carcinoma.
  • [MeSH-major] Bile Duct Neoplasms / metabolism. Carcinoma, Ductal / metabolism. Carcinoma, Papillary / metabolism. Mucins / secretion
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Cadherins / metabolism. Cholangiocarcinoma. Cyclin D1 / metabolism. Disease Progression. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Keratin-20 / metabolism. Matrix Metalloproteinase 7 / metabolism. Matrix Metalloproteinase 9 / metabolism. Mucin-1 / metabolism. Mucin-2 / metabolism. Neoplasm Invasiveness / pathology. Pancreatic Neoplasms / pathology. Phenotype. beta Catenin / metabolism

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  • (PMID = 19680592.001).
  • [ISSN] 1868-6982
  • [Journal-full-title] Journal of hepato-biliary-pancreatic sciences
  • [ISO-abbreviation] J Hepatobiliary Pancreat Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Cadherins; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / MUC1 protein, human; 0 / MUC2 protein, human; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins; 0 / beta Catenin; 136601-57-5 / Cyclin D1; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.35 / Matrix Metalloproteinase 9
  • [Number-of-references] 56
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28. Thirot-Bidault A, Lazure T, Ples R, Dimet S, Dhalluin-Venier V, Fabre M, Pelletier G: [Pancreatic intraductal tubular carcinoma: a sub-group of intraductal papillary-mucinous tumors or a distinct entity? A case report and review of the literature]. Gastroenterol Clin Biol; 2006 Nov;30(11):1301-4
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  • [Title] [Pancreatic intraductal tubular carcinoma: a sub-group of intraductal papillary-mucinous tumors or a distinct entity? A case report and review of the literature].
  • [Transliterated title] Carcinome tubuleux intracanalaire pancréatique: sous-groupe ou entité distincte des tumeurs intracanalaires papillaires mucineuses? A propos d'un cas et revue de la littérature.
  • The intraductal tumor showed a cribriform pattern, atypical cells without mucus and a MUC1+, MUC2-, MUC5AC- phenotype, all characteristics of intraductal tubular carcinoma, a new entity described by Japanese authors.
  • The differential diagnosis and its relationship with intraductal papillary-mucinous tumors are discussed.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Immunohistochemistry / methods. Male. Pancreatectomy / methods

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  • (PMID = 17185972.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 13
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29. Amonkar GP, Amonkar PP, Rege JD: Bilateral axillary apocrine nevi--a case report. Indian J Pathol Microbiol; 2005 Jan;48(1):22-3
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  • Apocrine glands are tubular glands, which function as scent glands.
  • [MeSH-major] Adenocarcinoma / pathology. Apocrine Glands / pathology. Axilla / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16758779.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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30. Oprić D, Fajdić J, Hrgović Z, Granić M, Milosević Z, Gugić D, Oprić S, Babić D, Fassbender WJ: Radial scar of the breast--a confusing lesion. Adv Med Sci; 2007;52:257-61
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  • It looks like a tubular carcinoma but histologically we can see two rows of cells in tubules.
  • Authors reanalyzed 21 from 26 woman with the radial scar diagnosis.
  • Aim of our study was to investigate the different morphologic changes in view of differential diagnosis, frequency and potential prognostic importance of the different lesions.
  • According to our findings we can conclude that the radial scar is unpalpable, subclinical lesion which can be seen on mammography but the final diagnosis is histological.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma / diagnosis. Cicatrix / diagnosis
  • [MeSH-minor] Adult. Aged. Breast / pathology. Breast Diseases / diagnosis. Breast Diseases / pathology. Cell Proliferation. Female. Humans. Mammography / methods. Middle Aged. Precancerous Conditions. Radiography / methods. Retrospective Studies

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  • (PMID = 18217429.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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31. Satoh Y, Hoshi R, Tsuzuku M, Ishikawa Y, Inamura K, Horai T: Cytology of pulmonary adenocarcinomas showing enteric differentiation. Acta Cytol; 2006 May-Jun;50(3):250-6
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  • [Title] Cytology of pulmonary adenocarcinomas showing enteric differentiation.
  • OBJECTIVE: To evaluate cytologic differences between primary pulmonary adenocarcinomas showing enteric differentiation (PAED) primary pulmonary adenocarcinomas of ordinary structure (PAC) and pulmonary metastases from colorectal carcinomas (MCR).
  • Aspiration cytologic and/or imprint smears of routine samples stained by the Papanicolaou method from the PAED cases were reviewed in comparison with 10 cases each of PAC showing a tubular pattern and MCR.
  • CONCLUSION: Although diagnosis of PAED by routine cytology is difficult due to the features of the lesion, differential diagnosis between PAED, PAC and MCR is a possible using conventional cytologic criteria.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Colorectal Neoplasms / pathology. Lung / pathology. Lung Neoplasms / pathology. Lung Neoplasms / secondary
  • [MeSH-minor] Aged. Biopsy, Needle. Cell Differentiation. Cell Nucleus / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16780017.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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32. Chetty R, Serra S: Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm. Histopathology; 2009 Sep;55(3):270-6
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  • [Title] Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm.
  • AIMS: Intraductal tubular adenoma (ITA) is an uncommon intraluminal polypoid lesion that occurs in the main pancreatic duct and involves the main pancreatic duct in the region of head or body.
  • METHODS AND RESULTS: ITA is composed of tightly packed tubular structures with focal cystic dilation and papillary areas lined by gastric/pyloric epithelium showing minimal to mild cytological atypia.
  • Its relationship to intraductal tubular carcinoma remains to be elucidated.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Adenoma / pathology. Carcinoma in Situ / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • [CommentIn] Histopathology. 2010 Jun;56(7):968-9; author reply 969 [20636797.001]
  • (PMID = 19723141.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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33. Duncan LD, Jacob S, Atkinson S: Fine needle aspiration cytologic findings of micropapillary carcinoma in the lung: a case report. Acta Cytol; 2007 Jul-Aug;51(4):605-9
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  • [Title] Fine needle aspiration cytologic findings of micropapillary carcinoma in the lung: a case report.
  • BACKGROUND: Micropapillary carcinoma is a variant of adenocarcinoma described in many anatomic sites and most recently in the lung.
  • A core biopsy of this lesion revealed an estrogen and progesterone receptor positive tubular carcinoma.
  • The diagnosis of adenocarcinoma with micropapillary features was made by fine needle aspiration cytology (FNAC).
  • The lobectomy specimen showed a combination of adenocarcinoma, papillary adenocarcinoma and micropapillary carcinoma.
  • CONCLUSION: Micropapillary carcinoma is a unique variant of adenocarcinoma, having important clinical associations because of its propensity for angiolymphatic invasion and higher stage at disease presentation.
  • This case demonstrates the cytomorphologic characteristics of micropapillary carcinoma in a transthoracic FNA of the lung.
  • [MeSH-major] Carcinoma, Papillary / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Cell Aggregation. Female. Humans. Lymphatic Metastasis / pathology. Middle Aged

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  • (PMID = 17718135.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Song HS, Kim IH, Sohn SS, Kwon KY, Lee WS: Prognostic significance of immunohistochemical expression of p53 and retinoblastoma gene protein (pRB) in curatively resected gastric cancer. Korean J Intern Med; 2005 Mar;20(1):1-7
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  • BACKGROUND: The aim of this study was to determine the prognostic significance of the expression of p53 and retinoblastoma (Rb) gene products in cases of curatively resected gastric adenocarcinoma, by immunohistochemical analysis.
  • Tubular type was found to frequently exhibit higher levels of p53 expression (high expression in 44.2%) than signet ring cell type (high expression in 26.0%) (p = 0.042).
  • [MeSH-major] Adenocarcinoma / genetics. Retinoblastoma Protein / metabolism. Stomach Neoplasms / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 15906946.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Retinoblastoma Protein; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC3891404
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35. Ikeda K, Isomoto H, Oda H, Shikuwa S, Mizuta Y, Iwasaki K, Kohno S: Endoscopic submucosal dissection of a minute intramucosal adenocarcinoma in Barrett's esophagus. Dig Endosc; 2009 Jan;21(1):34-6
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  • [Title] Endoscopic submucosal dissection of a minute intramucosal adenocarcinoma in Barrett's esophagus.
  • Under a provisional diagnosis of differentiated adenocarcinoma without local lymph node metastasis, endoscopic submucosal dissection (ESD) was carried out.
  • Histopathological examination confirmed intramucosal well-differentiated tubular adenocarcinoma without angiolymphatic invasion adjacent to the muscularis mucosae.
  • [MeSH-major] Adenocarcinoma / surgery. Barrett Esophagus / complications. Esophageal Neoplasms / surgery

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  • (PMID = 19691799.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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36. Grunwald S, Heyer H, Kühl A, Schwesinger G, Schimming A, Köhler G, Ohlinger R: Radial scar/complex sclerosing lesion of the breast--value of ultrasound. Ultraschall Med; 2007 Apr;28(2):206-11
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  • PURPOSE: Although benign, radial scar/complex sclerosing adenosis is a lesion which histopathologically resembles tubular carcinoma.
  • On physical examination, it is difficult to distinguish radial scar from a malignant tumour.

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  • (PMID = 16955394.001).
  • [ISSN] 0172-4614
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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37. Ota S, Tsuchiya K, Anno M, Akiyamat H: [An autopsy case of miliary brain metastases]. No To Shinkei; 2006 Feb;58(2):161-5
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  • A 57-year-old man was admitted to our hospital with a diagnosis of psychiatric emergency.
  • Brain CT was also normal, therefore it was difficult to make a diagnosis.
  • But, we could clinically diagnose him as having pulmonary adenocarcinoma with numerous metastatic nodules of the brain.
  • Histological examination disclosed multiple metastases from a well-differentiated adenocarcinoma with a predominant tubular pattern.
  • Many pseudorosettes were recognized and carcinoma cells, extending through perivascular spaces into the subarachnoid space, were noticed.
  • [MeSH-major] Adenocarcinoma / pathology. Brain Neoplasms / pathology. Brain Neoplasms / secondary. Lung Neoplasms / pathology

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  • (PMID = 16519114.001).
  • [ISSN] 0006-8969
  • [Journal-full-title] Nō to shinkei = Brain and nerve
  • [ISO-abbreviation] No To Shinkei
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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38. Nakayama T, Ling ZQ, Mukaisho K, Hattori T, Sugihara H: Lineage analysis of early and advanced tubular adenocarcinomas of the stomach: continuous or discontinuous? BMC Cancer; 2010;10:311
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  • [Title] Lineage analysis of early and advanced tubular adenocarcinomas of the stomach: continuous or discontinuous?
  • BACKGROUND: Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs.
  • The aim of this study was to clarify the extent of overlap of genetic lineages between early and advanced tubular adenocarcinomas (TUBs) of the stomach.
  • [MeSH-major] Adenocarcinoma / genetics. Cell Lineage / genetics. Proto-Oncogene Proteins c-myc / genetics. Stomach Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 20565940.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MYC protein, human; 0 / Proto-Oncogene Proteins c-myc; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC2898698
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39. Ferlicot S, Lupo A, Lazure T, Bedossa P, Vieillefond A: A novel entity: low-grade mucinous tubular renal carcinoma. Histopathology; 2005 Aug;47(2):218-9
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  • [Title] A novel entity: low-grade mucinous tubular renal carcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology

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  • (PMID = 16045786.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Mucin-1; 0 / Plant Lectins; 0 / Ulex europaeus lectins; 0 / Vimentin; 68238-35-7 / Keratins
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40. Ha TK, An JY, Youn HK, Noh JH, Sohn TS, Kim S: Indication for endoscopic mucosal resection in early signet ring cell gastric cancer. Ann Surg Oncol; 2008 Feb;15(2):508-13
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  • [Title] Indication for endoscopic mucosal resection in early signet ring cell gastric cancer.
  • BACKGROUND: The aim of this study was to compare the clinicopathological characteristics of an early signet ring cell carcinoma (SRC) with an early undifferentiated carcinoma (mucinous, poorly differentiated adenocarcinoma) and early differentiated carcinoma (well or moderately differentiated tubular adenocarcinoma, papillary adenocarcinoma) and find indications for endoscopic mucosal resection (EMR) in early SRC.
  • Among them, 388 patients with SRC were compared with 253 patients with undifferentiated carcinoma (UDC) and 879 with a differentiated carcinoma (DC).
  • [MeSH-major] Carcinoma, Signet Ring Cell / surgery. Endoscopy, Gastrointestinal. Stomach Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / surgery. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Prognosis. Retrospective Studies. Risk Factors

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  • [CommentIn] Ann Surg Oncol. 2008 Dec;15(12):3620-1; author reply 3622 [18246399.001]
  • (PMID = 18071825.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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41. Adachi T, Tajima Y, Kuroki T, Mishima T, Kitasato A, Tsuneoka N, Kanematsu T: Chemopreventive effects of a selective cyclooxygenase-2 inhibitor (etodolac) on chemically induced intraductal papillary carcinoma of the pancreas in hamsters. Carcinogenesis; 2008 Apr;29(4):830-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemopreventive effects of a selective cyclooxygenase-2 inhibitor (etodolac) on chemically induced intraductal papillary carcinoma of the pancreas in hamsters.
  • The present study was designed to determine whether etodolac, a selective cyclooxygenase-2 inhibitor, prevents chemically induced intraductal papillary carcinoma (IPC) in the main pancreatic duct of hamsters.
  • The incidence of induced pancreatic carcinoma was 93, 81 and 72% in groups CE, ET and ET4, respectively.
  • The pancreatic carcinomas were histologically classified into four types, i.e. tubular, papillary, cyst adenocarcinoma and IPC.
  • The proliferating cell nuclear antigen labeling indices in the non-cancerous epithelial cells of the main pancreatic duct were 2.8 and 6.8% in groups ET4 and ET, respectively, and were significantly lower than that in group CE (10.8%).
  • Suppression of epithelial cell proliferation of the main pancreatic duct was considered as a possible mechanism of cancer prevention in this hamster model.
  • [MeSH-major] Adenocarcinoma, Papillary / drug therapy. Anticarcinogenic Agents / therapeutic use. Carcinoma, Pancreatic Ductal / drug therapy. Cyclooxygenase 2 / metabolism. Cyclooxygenase 2 Inhibitors / therapeutic use. Etodolac / therapeutic use

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  • (PMID = 18296437.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; 0 / Cyclooxygenase 2 Inhibitors; 2M36281008 / Etodolac; EC 1.14.99.1 / Cyclooxygenase 2
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42. Aslan DL, Jessurun J, Gulbahce HE, Pambuccian SE, Adsay V, Mallery JS: Endoscopic ultrasound-guided fine needle aspiration features of a pancreatic neoplasm with predominantly intraductal growth and prominent tubular cytomorphology: intraductal tubular carcinoma of the pancreas? Diagn Cytopathol; 2008 Nov;36(11):833-9
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  • [Title] Endoscopic ultrasound-guided fine needle aspiration features of a pancreatic neoplasm with predominantly intraductal growth and prominent tubular cytomorphology: intraductal tubular carcinoma of the pancreas?
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / ultrasonography. Endosonography. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / ultrasonography

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  • (PMID = 18831024.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-7; EC 1.11.1.7 / Peroxidase
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43. Murakami Y, Uemura K, Sasaki M, Morifuji M, Hayashidani Y, Sudo T, Sueda T: Duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis. J Gastrointest Surg; 2005 Mar;9(3):389-92
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  • During the current admission, the patient was diagnosed with adenocarcinoma in the Vater's ampulla using imaging and pathological examinations.
  • The tumor was a well-differentiated tubular adenocarcinoma and no other polyps were identified in the duodenum by pathological examination.
  • This lesion was completely resected by endoscopic mucosal resection and the resected specimen revealed well-differentiated tubular adenocarcinoma in an adenomatous lesion.
  • [MeSH-major] Adenocarcinoma / surgery. Adenomatous Polyposis Coli / secondary. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / secondary. Duodenal Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Aulmann S, Elsawaf Z, Penzel R, Schirmacher P, Sinn HP: Invasive tubular carcinoma of the breast frequently is clonally related to flat epithelial atypia and low-grade ductal carcinoma in situ. Am J Surg Pathol; 2009 Nov;33(11):1646-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Invasive tubular carcinoma of the breast frequently is clonally related to flat epithelial atypia and low-grade ductal carcinoma in situ.
  • Low-grade precursor lesions, such flat epithelial atypia (FEA), low-grade ductal carcinoma in situ (lg-DCIS), and lobular neoplasia (LN) often coexist with invasive tubular carcinomas (TCs) of the breast.
  • In these lesions (22 FEA, 10 lg-DCIS, 3 LN), loss of heterozygosity was most frequently observed on the long arm of chromosome 16 as well as at chromosome 8p21, 3p14, 1p36 and 11q14 with a high degree of homology of allelic losses between FEA, lg-DCIS and tubular carcinomas.
  • In the adjacent invasive tubular carcinomas, mitochondrial DNA sequencing revealed identical mutation patterns in 50% of the lg-DCIS and in 12 of 21 (57%) informative cases of FEA.
  • No direct association was seen between TC and LN or columnar cell lesions without nuclear atypia.
  • Our data indicate, that in the majority of cases lg-DCIS and FEA are directly related to tubular breast cancer with a possible precursor role.
  • [MeSH-major] Adenocarcinoma / pathology. Breast Neoplasms / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Lobular / pathology

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  • (PMID = 19675453.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Mitochondrial; 0 / DNA, Neoplasm
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45. Oh HE, Chetty R: Intramucosal ganglion cells are common in diverticular disease. Pathology; 2008 Aug;40(5):470-4
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  • Intramucosal ganglion cells occurred throughout the colorectum within the muscularis mucosae or lamina propria in normal mucosa in 11 cases and in a further 26 colorectal specimens with Crohn's disease (11/20), ulcerative colitis (11/20), adenocarcinoma (1/20), tubular adenoma (2/20), and mucosal prolapse (1/20).

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  • (PMID = 18604732.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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46. Yamato H, Kawakami H, Kuwatani M, Shinada K, Kondo S, Kubota K, Asaka M: Pancreatic carcinoma associated with portal vein tumor thrombus: three case reports. Intern Med; 2009;48(3):143-50
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  • [Title] Pancreatic carcinoma associated with portal vein tumor thrombus: three case reports.
  • Pancreatic carcinoma associated with portal vein tumor thrombus (PVTT) is rare.
  • Here, we report three cases of resected pancreatic carcinoma associated with PVTT.
  • The pathological diagnoses of the tumors were two cases of tubular adenocarcinoma and one case of nonfunctioning endocrine carcinoma.
  • [MeSH-major] Carcinoma / pathology. Pancreatic Neoplasms / pathology. Portal Vein / pathology. Thrombosis / pathology

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  • (PMID = 19182424.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 20
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47. Pavić I, Marusić Z, Mijić A, Balicević D, Kruslin B, Tomas D: A case of signet-ring cell carcinoma of the gallbladder: immunohistochemistry and differential diagnosis. Acta Clin Croat; 2010 Jun;49(2):159-62
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  • [Title] A case of signet-ring cell carcinoma of the gallbladder: immunohistochemistry and differential diagnosis.
  • The morphological spectrum of gallbladder carcinoma is broad and variable.
  • Most of these tumors are tubular adenocarcinomas.
  • One of such tumors is the signet-ring cell carcinoma, which is a highly aggressive, mucin producing variant of gallbladder adenocarcinoma predominantly or exclusively composed of signet-ring cells.
  • Histologically, these tumors are similar to their counterparts in other organs such as stomach, colon and breast, and should not be misinterpreted as metastatic carcinoma from one of these primary sites.
  • The literature about this variant of carcinoma is sparse and little is known about it.
  • We found only three cases of signet-ring cell carcinoma of the gallbladder previously reported.
  • We present the case of an 86-year-old woman with signet-ring cell carcinoma of the gallbladder and discuss the potential diagnostic dilemmas
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 21086733.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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48. Namikawa T, Kobayashi M, Okamoto K, Okabayashi T, Akimori T, Sugimoto T, Hanazaki K: Recurrence of gastric cancer in the jejunal pouch after completion gastrectomy. Gastric Cancer; 2007;10(4):256-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histopathologically, moderately differentiated tubular adenocarcinoma involving the muscular layer, without lymphatic metastases, was recognized.
  • [MeSH-major] Adenocarcinoma / surgery. Anastomosis, Roux-en-Y. Gastrectomy. Neoplasm Recurrence, Local. Neoplasm Seeding. Stomach Neoplasms / surgery

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  • [Cites] Gastric Cancer. 1999 Nov;2(3):194-197 [11957096.001]
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  • (PMID = 18095082.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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49. Nakanishi M, Kuwamura M, Yamate J, Fujita D, Sasai H: Gastric adenocarcinoma with ossification in a ferret (Mustela putorius furo). J Vet Med Sci; 2005 Sep;67(9):939-41
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  • [Title] Gastric adenocarcinoma with ossification in a ferret (Mustela putorius furo).
  • Histopathologically, the mass was composed of neoplastic proliferation of well-differentiated epithelial cells, showing tubular or glandular growth patterns.
  • A diagnosis of gastric adenocarcinoma with ossification was made.

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  • (PMID = 16210808.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bone Morphogenetic Protein 6; 0 / Bone Morphogenetic Proteins
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50. Stolnicu S, Rădulescu D, Pleşea IE, Dobru D, Podoleanu C, Pintilei DR: The value of intraoperative diagnosis in breast lesions. Rom J Morphol Embryol; 2006;47(2):119-23
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  • [Title] The value of intraoperative diagnosis in breast lesions.
  • Frozen section examination is aimed at making a preoperative diagnosis, determining the benign or malignant nature of a breast lesion, but also the most suitable surgical procedure.
  • The following terms were used for describing the intraoperative diagnosis: negative, positive, and await paraffin section.
  • After the frozen section diagnosis was made, the frozen tissue was thawed to room temperature and fixed in formalin overnight for further paraffin processing.
  • In 7% of the cases the diagnosis could not be made on frozen section.
  • CONCLUSIONS: Despite the raging popularity of aspiration cytology, frozen section still stands out as the method of choice for rapid diagnosis.
  • Frozen section is not indicated to be performed on mammographically detected lesions, small lesions, papillary lesions, proliferating fibrocystic disease, or tubular carcinoma.
  • [MeSH-minor] Carcinoma in Situ / pathology. Fibrocystic Breast Disease / pathology. Humans. Intraoperative Period. Neoplasm Invasiveness. Retrospective Studies

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  • (PMID = 17106518.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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51. Wagner TD, Wharton K, Donohue K, Sperl ML, Flaherty L, Jaggernauth W, Yap JC, Fernando SA, Landry JC, Yang GY: Pure tubular breast carcinoma: a 34 year study of outcomes. Breast J; 2008 Sep-Oct;14(5):512-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pure tubular breast carcinoma: a 34 year study of outcomes.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Breast Neoplasms / epidemiology. Breast Neoplasms / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Carcinoma, Intraductal, Noninfiltrating / epidemiology. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Intraductal, Noninfiltrating / therapy. Chemotherapy, Adjuvant. Female. Humans. Immunohistochemistry. Incidence. Mastectomy, Segmental / methods. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant. Registries. Retrospective Studies. Risk Assessment. Survival Analysis. United States / epidemiology

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  • (PMID = 18821938.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
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52. Lopez-Garcia MA, Geyer FC, Natrajan R, Kreike B, Mackay A, Grigoriadis A, Reis-Filho JS, Weigelt B: Transcriptomic analysis of tubular carcinomas of the breast reveals similarities and differences with molecular subtype-matched ductal and lobular carcinomas. J Pathol; 2010 Sep;222(1):64-75
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  • [Title] Transcriptomic analysis of tubular carcinomas of the breast reveals similarities and differences with molecular subtype-matched ductal and lobular carcinomas.
  • Tubular carcinoma (TC) is an uncommon special type of breast cancer characterized by an indolent clinical course.
  • Although described as part of a spectrum of related lesions named 'low-grade breast neoplasia family' due to immunophenotypical and genetic similarities, TCs, low-grade invasive ductal carcinomas of no special type (IDC-NSTs), and classic invasive lobular carcinomas (ILCs) significantly differ in terms of histological features and clinical outcome.
  • Transcriptomic differences between TCs and molecular subtype-matched classic ILCs were more overt, predominantly due to lower expression of proliferation and cell cycle genes in TCs and down-regulation of cell adhesion/extracellular matrix-related genes in classic ILCs.
  • [MeSH-major] Breast Neoplasms / genetics. Carcinoma, Ductal, Breast / genetics. Carcinoma, Lobular / genetics

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  • (PMID = 20593406.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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53. Obana T, Fujita N, Noda Y, Kobayashi G, Ito K, Horaguchi J, Takasawa O, Tsuchiya T, Sawai T: Small pancreatic cancer with pancreas divisum preoperatively diagnosed by pancreatic juice cytology. Intern Med; 2009;48(18):1661-6
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  • Cytology of pancreatic juice obtained from the dorsal pancreas after minor papilla sphincterotomy revealed the presence of adenocarcinoma cells.
  • Pancreatoduodenectomy was performed under the diagnosis of pancreatic head cancer with pancreas divisum.
  • Histological examination revealed moderately-differentiated tubular adenocarcinoma 20 mm in diameter, located in the pancreatic head.
  • When pancreatic duct stenosis also exists in such cases, even if a tumor is not clearly visualized by diagnostic imaging, vigorous examinations such as pancreatic juice cytology are recommended to establish an accurate diagnosis.
  • [MeSH-major] Pancreas / abnormalities. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Cholangiopancreatography, Endoscopic Retrograde. Female. Humans. Middle Aged. Pancreatic Juice / cytology

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  • (PMID = 19755770.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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54. Hirakawa H, Nakayama T, Shibata K, Sekine I: Association of cellular localization of glycogen synthase kinase 3beta in the digestive tract with cancer development. Oncol Rep; 2009 Sep;22(3):481-5
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  • In normal simple columnar epithelium, GSK-3beta was localized with tight junction-associated protein ZO-1 in a single line at the apical cell border.
  • GSK-3beta and ZO-1 were localized in the apical regions of tubular adenocarcinoma, similar to their localization in normal epithelium; however, their localization was different at the invasive front of the cancer and was found to be associated with lymphatic invasion.
  • In signet-ring cell carcinoma of the stomach, the expression of these proteins was reduced and dot-like expression was observed in each cell of the signet-ring cell carcinoma.
  • We speculated that GSK-3beta is involved in glandular structure formation and that the non-apical localization of membrane-localized GSK-3beta in tubular adenocarcinoma is associated with cancer development.
  • [MeSH-minor] Adenocarcinoma / enzymology. Aged. Female. Genes, APC. Humans. Immunohistochemistry. Intestinal Mucosa / enzymology. Male. Membrane Proteins / analysis. Middle Aged. Phosphoproteins / analysis. Zonula Occludens-1 Protein

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  • (PMID = 19639192.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Phosphoproteins; 0 / TJP1 protein, human; 0 / Zonula Occludens-1 Protein; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3
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55. Hisa T, Nobukawa B, Suda K, Ohkubo H, Shiozawa S, Ishigame H, Takamatsu M, Furutake M: Intraductal carcinoma with complex fusion of tubular glands without macroscopic mucus in main pancreatic duct: dilemma in classification. Pathol Int; 2007 Nov;57(11):741-5
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  • [Title] Intraductal carcinoma with complex fusion of tubular glands without macroscopic mucus in main pancreatic duct: dilemma in classification.
  • An 84-year-old man, who was being followed up after lobectomy for lung carcinoma, was referred for evaluation of a dilated main pancreatic duct (MPD) from the body to the tail.
  • Endoscopic retrograde pancreatography showed an occlusion of the MPD in the body, and brush cytology indicated malignant cells.
  • Histologically, the mass consisted of a complex fusion of tubular glands with atypical nuclei, which did not have intracellular mucus and oncocytic cytoplasm.
  • Unfortunately the patient died of brain metastasis from lung carcinoma 15 months later.
  • A review of reported cases of intraductal tubular tumors of the pancreas showed that the present case involved characteristics and immunohistochemical staining pattern similar to those of intraductal tubular carcinoma, although it might not be described as a typical intraductal tubular carcinoma under the existing Japanese rules.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / classification. Mucus / metabolism. Neoplasms, Second Primary / classification. Pancreatic Neoplasms / classification

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  • (PMID = 17922686.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / MUC1 protein, human; 0 / Mucin-1
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56. Noda H, Kato T, Kamiyama H, Toyama N, Konishi F: En bloc right hemicolectomy and pancreaticoduodenectomy with superior mesenteric vein resection for advanced right-sided colon cancer. Clin J Gastroenterol; 2010 Oct;3(5):259-61
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  • A 58-year-old female was referred to our hospital with a diagnosis of bowel obstruction due to advanced transverse colon cancer invading the duodenum.
  • A histologic examination also revealed a well-differentiated tubular adenocarcinoma invading the duodenum.

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  • (PMID = 26190332.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Colon cancer / Pancreaticoduodenectomy / Superior mesenteric vein
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57. Ibrahim OO, Anjorin AS, Afolayan AE, Badmos KB: Pathological characterization of colorectal polyps in Ilorin, Nigeria. Afr J Med Med Sci; 2010 Sep;39(3):215-9
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  • Colorectal polyps especially the adenomas are recognized precursors of colorectal carcinoma.
  • Identification and removal of such polyps before malignant transformation could reduce the burden of colorectal carcinoma.
  • This is a retrospective review of all cases ofcolorectal polyps that were received, processed and had histological diagnosis in our centre between 1979 and 2008 using the request cards and hematoxylin and eosin stained slides.
  • Of the adenomas, 11 (58.8%) were tubular, 5 (29.4%) were villous, 1 (5.9%) was tubulovillous, and one was a villous adenoma with a focus of malignant transformation.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Biopsy. Cell Transformation, Neoplastic / pathology. Child. Child, Preschool. Female. Hospitals, Teaching. Humans. Infant. Infant, Newborn. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies. Sex Distribution. Young Adult

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  • (PMID = 21416791.001).
  • [ISSN] 0309-3913
  • [Journal-full-title] African journal of medicine and medical sciences
  • [ISO-abbreviation] Afr J Med Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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58. Dang LH, Chen F, Knock SA, Huang EH, Feng J, Appelman HD, Dang DT: CDX2 does not suppress tumorigenicity in the human gastric cancer cell line MKN45. Oncogene; 2006 Mar 30;25(14):2048-59
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  • [Title] CDX2 does not suppress tumorigenicity in the human gastric cancer cell line MKN45.
  • In mice, ectopic expression of CDX2 in the gastric mucosa gives rise to intestinal metaplasia and in one model, gastric carcinoma.
  • In humans, increased CDX2 expression is associated with gastric intestinal metaplasia and tubular adenocarcinomas.
  • The CDX2 gene in MKN45 gastric carcinoma cells was disrupted using targeted homologous recombination.
  • [MeSH-major] Adenocarcinoma / pathology. Homeodomain Proteins / physiology. Stomach Neoplasms / pathology
  • [MeSH-minor] Base Sequence. Cell Cycle. Cell Differentiation. Cell Division. Cell Line, Tumor. DNA Primers. Humans. Immunohistochemistry. Mutation. Recombination, Genetic. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16331267.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K08DK59970
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / DNA Primers; 0 / Homeodomain Proteins
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59. Li CI, Uribe DJ, Daling JR: Clinical characteristics of different histologic types of breast cancer. Br J Cancer; 2005 Oct 31;93(9):1046-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Among women aged 50-89 years at diagnosis, lobular and ductal/lobular carcinoma cases were more likely to be diagnosed with stage III/IV, > or =5.0 cm, and node-positive tumours compared to ductal carcinoma cases.
  • Mucinous, comedo, tubular, and medullary carcinomas were less likely to present at an advanced stage.
  • Lobular, ductal/lobular, mucinous, tubular, and papillary carcinomas were less likely, and comedo, medullary, and inflammatory carcinomas were more likely to be oestrogen receptor (ER) negative/progesterone receptor (PR) negative and high grade (notably, 68.2% of medullary carcinomas were ER-/PR- vs 19.3% of ductal carcinomas).
  • Inflammatory carcinomas are associated with more aggressive tumour phenotypes, and mucinous, tubular, and papillary tumours are associated with less aggressive phenotypes.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / pathology. Breast Neoplasms / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Papillary / pathology. Neoplasms, Ductal, Lobular, and Medullary / pathology

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  • (PMID = 16175185.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U54 CA132383; United States / NCI NIH HHS / CA / U56 CA096286; United States / NCI NIH HHS / CA / U56 CA096288
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ PMC2361680
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60. Kanda T, Yoshida H, Mamada Y, Taniai N, Kawano Y, Mizuguchi Y, Shimizu T, Takahashi T, Ueda J, Kato S, Akimaru K, Tajiri T, Fukuda Y: Resection of liver metastases from an alpha-fetoprotein-producing gastric cancer. J Nippon Med Sch; 2005 Feb;72(1):66-70
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  • The tumor was a moderately differentiated tubular adenocarcinoma with invasion of the muscularis propria.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Biomarkers, Tumor / biosynthesis. Hepatectomy. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Stomach Neoplasms / pathology. alpha-Fetoproteins / biosynthesis

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  • (PMID = 15834210.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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61. Augoff K, Rabczynski J, Tabola R, Czapla L, Ratajczak K, Grabowski K: Immunohistochemical study of decorin expression in polyps and carcinomas of the colon. Med Sci Monit; 2008 Oct;14(10):CR530-5
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  • [Title] Immunohistochemical study of decorin expression in polyps and carcinomas of the colon.
  • It was hypothesized that physiological expression of decorin may be associated with cellular senescence of the colorectal mucosa and that its down-regulation, promoting an increase in cellular proliferation, could participate in the progression of adenoma to adenocarcinoma.
  • MATERIAL/METHODS: Tissue samples were obtained from 41 patients with different types of colonic polyps (6 hyperplastic adenomas, 34 neoplastic adenomas, and 1 adenomatous polyp with focal carcinoma) and 12 patients with colon cancer.
  • RESULTS: Normal and hyperplastic tissues and the majority of tubular adenomas showed strong expression of decorin in the stroma.
  • Weak decorin immunoreactivity in stroma adjacent to clusters of cancerous cells was also found in most cases of common types of adenocarcinoma, but not in adenocarcinoma mucinosum.
  • CONCLUSIONS: The expression of decorin may be involved in the differentiation of colonic polyps and reduced expression of decorin may abrogate the defensive potential of stromal tissue and promote the development of common types of colon carcinoma.

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  • (PMID = 18830193.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / DCN protein, human; 0 / Decorin; 0 / Extracellular Matrix Proteins; 0 / Proteoglycans
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62. Ding HY, Yang GZ: [Clinicopathological features of the mucocele-like lesions in the breast]. Zhonghua Bing Li Xue Za Zhi; 2008 Jan;37(1):31-4
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  • METHODS: Nine cases of mucocele-like lesions in the breast were reported for the morphological and immunohistochemical features, the differential diagnosis, and a literature review.
  • Histologically, the lesions consisted of multiple cysts filled with colloid, these cysts were lined with tubular, cuboidal or columnar epithelium.
  • CONCLUSION: Mucocele-like lesions of the breast is a group of mostly benign disease, and the differential diagnosis should include mucinous carcinoma.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Diagnosis, Differential. Hyperplasia / pathology. Mucocele / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Carcinoma in Situ / diagnosis. Female. Gene Expression Regulation, Neoplastic / physiology. Humans. Intestinal Neoplasms / pathology

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  • (PMID = 18509982.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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63. Shimamura K, Kurosaki I, Sato D, Takano K, Yokoyama N, Sato Y, Hatakeyama K, Nakadaira K, Yagi M: Intrahepatic cholangiocarcinoma arising 34 years after excision of a type IV-A congenital choledochal cyst: report of a case. Surg Today; 2009;39(3):247-51
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  • Microscopically, the tumor was confirmed to be moderate-to-well-differentiated tubular adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / etiology. Choledochal Cyst / complications. Choledochal Cyst / surgery

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  • (PMID = 19280286.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 31
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64. Lima WR, Parreira KS, Devuyst O, Caplanusi A, N'kuli F, Marien B, Van Der Smissen P, Alves PM, Verroust P, Christensen EI, Terzi F, Matter K, Balda MS, Pierreux CE, Courtoy PJ: ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells. J Am Soc Nephrol; 2010 Mar;21(3):478-88
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  • The transcription factor zonula occludens 1 (ZO-1)-associated nucleic acid binding protein (ZONAB) can shuttle between tight junctions and nuclei, promoting cell proliferation and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA), but whether it also represses epithelial differentiation is unknown.
  • Here, during mouse kidney ontogeny and polarization of proximal tubular cells (OK cells), ZONAB and PCNA levels decreased in parallel and inversely correlated with increasing apical differentiation, reflected by expression of megalin/cubilin, maturation of the brush border, and extension of the primary cilium.
  • Conversely, ZONAB reexpression and loss of apical differentiation markers provided a signature for renal clear cell carcinoma.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / physiopathology. Adult. Animals. Cell Differentiation / physiology. Cell Division / physiology. Cell Line, Tumor. Cell Polarity / physiology. Down-Regulation / physiology. Epithelial Cells / cytology. Epithelial Cells / physiology. Gene Expression Regulation, Developmental. Humans. Kidney Neoplasms / pathology. Kidney Neoplasms / physiopathology. Low Density Lipoprotein Receptor-Related Protein-2 / genetics. Mice. Mice, Inbred C57BL. Opossums. Promoter Regions, Genetic / physiology. RNA, Messenger / metabolism. Receptors, Cell Surface / genetics. Transcription Factors. Transfection

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  • (PMID = 20133480.001).
  • [ISSN] 1533-3450
  • [Journal-full-title] Journal of the American Society of Nephrology : JASN
  • [ISO-abbreviation] J. Am. Soc. Nephrol.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0700743; United Kingdom / Medical Research Council / / G0900098
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCAAT-Enhancer-Binding Proteins; 0 / CSDA protein, human; 0 / Csda protein, mouse; 0 / DNA-Binding Proteins; 0 / Heat-Shock Proteins; 0 / Low Density Lipoprotein Receptor-Related Protein-2; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 0 / Transcription Factors; 0 / intrinsic factor-cobalamin receptor
  • [Other-IDs] NLM/ PMC2831853
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65. Matsukawa A, Kurano R, Takemoto T, Kagayama M, Ito T: Chief cell hyperplasia with structural and nuclear atypia: a variant of fundic gland polyp. Pathol Res Pract; 2005;200(11-12):817-21
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  • [Title] Chief cell hyperplasia with structural and nuclear atypia: a variant of fundic gland polyp.
  • A case of an unusual variant of fundic gland polyp (FGP) composed of chief cell hyperplasia with structural and nuclear atypia in an 87-year-old woman is presented.
  • Altogether, the polyp in the fundus was diagnosed as an unusual variant of FGP with chief cell hyperplasia.
  • This FGP should be differentiated from tubular adenocarcinoma.
  • Proliferation of chief cells with occasional parietal cells is critical for the differential diagnosis.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Cell Count. Cell Nucleus / pathology. Cell Proliferation. Diagnosis, Differential. Female. Gastric Mucosa / chemistry. Gastric Mucosa / pathology. Humans. Hyperplasia. Ki-67 Antigen / analysis. Pepsinogen A / analysis

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  • (PMID = 15792126.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 9001-10-9 / Pepsinogen A
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66. Suda K, Nobukawa B, Yamasaki S, Abe K, Matsukuma S, Suzuki F: Invasive ductal adenocarcinoma of the pancreas may originate from the larger pancreatic duct: a study of 13 tumors less than 2 cm in diameter. J Hepatobiliary Pancreat Surg; 2007;14(3):283-8
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  • [Title] Invasive ductal adenocarcinoma of the pancreas may originate from the larger pancreatic duct: a study of 13 tumors less than 2 cm in diameter.
  • BACKGROUND/PURPOSE: We aimed to elucidate the origin/primary site of invasive ductal adenocarcinoma of the pancreas, based on the distribution of intraductal carcinoma components.
  • METHODS: Thirteen specimens from patients with invasive ductal adenocarcinoma (microscopically, less than 2 cm in diameter) of the pancreas were studied histopathologically.
  • Variants of invasive ductal adenocarcinoma and intraductal papillary-mucinous carcinoma were excluded.
  • RESULTS: Intraductal carcinoma components of invasive ductal adenocarcinoma were found in 12 of the specimens 13 (92%), and were observed within the tumor mass and/or on its boundary, or outside the tumor mass.
  • Intraductal components were characterized by low papillary projections lacking a fibrovascular core, with/without surrounding tubular structures, or by irregular stratification and pleomorphism of the epithelial cells.
  • Invasive components mostly showed a tubular pattern with desmoplasia.
  • CONCLUSIONS: Invasive ductal adenocarcinomas of the pancreas may originate most frequently from the main pancreatic duct or larger branch ducts, while the smaller ducts are less often the site of cancer origin.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Pancreaticoduodenectomy. Retrospective Studies. Severity of Illness Index

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  • (PMID = 17520204.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Japan
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67. Hwangbo S, Kim J, Kim H, Kim J, Kang C, Lee H: Two separated ileal adenocarcinomas in neurofibromatosis type 1. Yonsei Med J; 2007 Dec 31;48(6):1039-42
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  • [Title] Two separated ileal adenocarcinomas in neurofibromatosis type 1.
  • Here, we document a rare case of two separated ileal adenocarcinomas in NF-1.
  • The adenocarcinomas were surrounded by a diffuse tubular adenomatous lesion of the mucosa, and ganglion cells were scattered in the NF background.
  • We found this case meaningful for several reasons: two separated adenocarcinomas arising in an unusual ileal segment, the association with precancerous tubular adenoma, and the presence of ganglion cells, which suggests ganglioneuromatosis in NF-1.
  • [MeSH-major] Adenocarcinoma / pathology. Ileal Neoplasms / pathology. Neurofibromatosis 1 / pathology

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  • [Cites] Oncologist. 2000;5(6):477-85 [11110599.001]
  • [Cites] Gastroenterol Clin Biol. 2003 Feb;27(2):219-24 [12658132.001]
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  • (PMID = 18159599.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2628198
  • [Keywords] NOTNLM ; Neurofibromatosis / adenocarcinoma / ileum
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68. Sano T, Usuki H, Takebayashi R, Akamoto S, Inoue T, Kakinoki K, Hagiike M, Okano K, Izuishi K, Suzuki Y: [A case of Stage IV AFP producing gastric cancer with long-term survival treated by adjuvant chemotherapy with S-1]. Gan To Kagaku Ryoho; 2010 Mar;37(3):521-6
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  • The histological diagnosis was moderately-differentiated tubular adenocarcinoma and the pathological Stage was IV: T4 (diaphragm), N2, M0.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Cardia. Oxonic Acid / therapeutic use. Stomach Neoplasms / drug therapy. Tegafur / therapeutic use. alpha-Fetoproteins / biosynthesis

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  • (PMID = 20332696.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / alpha-Fetoproteins; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
  • [Number-of-references] 5
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69. Tanaka H, Takamori H, Eto S, Ozaki N, Akaboshi S, Nakahara O, Ida S, Furuhashi S, Abe S, Horino K, Beppu T, Baba H: [Acute liver injury with hepatic encephalopathy associated with gemcitabine administration for adjuvant chemotherapy in an HBV carrier with pancreatic cancer]. Gan To Kagaku Ryoho; 2010 Sep;37(9):1783-6
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  • The histopathological diagnosis was tubular adenocarcinoma of the pancreas.


70. Ichino N, Horiguchi Y, Imai H, Osakabe K, Nishikawa T, Sugita Y, Utsugi H, Togo Y, Sawai T, Mizoguchi Y: Contrast-enhanced sonography of pancreatic ductal carcinoma using agent detection imaging. J Med Ultrason (2001); 2006 Mar;33(1):29-35
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  • [Title] Contrast-enhanced sonography of pancreatic ductal carcinoma using agent detection imaging.
  • PURPOSE: The aim of this study was to evaluate the enhancement behavior of pancreatic ductal carcinoma by contrast-enhanced sonography with agent detection imaging (ADI), and to clarify the origin of microbubble signals by comparisons with histological findings of resected specimens.
  • METHODS: The subjects were 21 patients with resectable pancreatic carcinoma.
  • The final histological diagnosis was tubular adenocarcinoma in 20 cases, and anaplastic carcinoma in one case.
  • With respect to resectable cases, these enhancement patterns were compared with histological findings, i.e., the distribution of blood vessels in the tumor, remaining pancreatic tissues in the tumor, differentiation of types of adenocarcinoma, volume of stroma, and invasion types of carcinoma.
  • CONCLUSION: This study indicated that pancreatic ductal carcinoma is frequently enhanced by microbubbles, and the signals seem to originate from fine blood vessels and the remaining pancreatic tissues in the tumor.

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  • [Cites] Pancreas. 2004 Apr;28(3):335-43 [15084983.001]
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  • (PMID = 27277616.001).
  • [ISSN] 1346-4523
  • [Journal-full-title] Journal of medical ultrasonics (2001)
  • [ISO-abbreviation] J Med Ultrason (2001)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; agent detection imaging, Levovist / contrast-enhanced sonography / pancreatic ductal carcinoma
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71. Salarieh A, Sneige N: Breast carcinoma arising in microglandular adenosis: a review of the literature. Arch Pathol Lab Med; 2007 Sep;131(9):1397-9
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  • [Title] Breast carcinoma arising in microglandular adenosis: a review of the literature.
  • Most cases of microglandular adenosis are resolved after adequate excision, but more recent data suggest that this lesion may be a precursor for carcinoma, with atypical microglandular adenosis being an intermediate lesion.
  • Carcinomas arising in a background of microglandular adenosis, although they may be low grade, are commonly estrogen and progesterone receptor negative, in contrast to most conventional low-grade carcinomas unrelated to microglandular adenosis.
  • Diagnostic problems include differentiating microglandular adenosis from carcinoma and assessing the extent of the carcinoma component.
  • In this review, we discuss the histomorphologic and immunophenotypic characteristic of the spectrum of microglandular adenosis lesions with emphasis on diagnostic features distinguishing microglandular adenosis from well-differentiated carcinoma, in particular, tubular carcinoma, and assessment of surgical margins of excision in such lesions.
  • [MeSH-major] Breast Neoplasms / diagnosis. Fibrocystic Breast Disease / diagnosis
  • [MeSH-minor] Breast / metabolism. Breast / pathology. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. S100 Proteins / metabolism

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  • (PMID = 17824796.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Number-of-references] 10
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72. Nowicki MJ, Bishop PR, Subramony C, Wyatt-Ashmead J, May W, Crawford M: Colonic chicken-skin mucosa in children with polyps is not a preneoplastic lesion. J Pediatr Gastroenterol Nutr; 2005 Nov;41(5):600-6
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  • Colonic polyps are common both in adults and children; however, the malignant potential varies according to the type of polyp.
  • Most childhood polyps are solitary juvenile polyps, which have negligible malignant potential.
  • Chicken-skin mucosa (CSM) is an endoscopic finding initially described associated with adenomatous polyps and adenocarcinoma, suggesting a preneoplastic lesion.
  • To determine whether CSM represents a preneoplastic lesion, we studied endoscopic colonic mucosal biopsies for markers of cell replication (Ki-67) and malignant transformation (p53) in mucosal biopsies of CSM, normal colonic tissue, tubular adenomas, and adenocarcinomas.
  • The degree of Ki-67-positive staining cells was similar for CSM and normal colonic tissue, whereas there was significantly increased staining for both tubular adenomas and adenocarcinomas.
  • There was no evidence of p53 staining in CSM and normal colonic mucosa, whereas there was varying degrees of staining in tubular adenomas and adenocarcinomas.
  • The association of CSM with benign juvenile polyps and the absence of histologic markers for increased replication and malignant transformation support the notion that this endoscopic finding is not preneoplastic.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma / diagnosis. Adenoma / metabolism. Adenoma / pathology. Biomarkers, Tumor / analysis. Biopsy. Child. Child, Preschool. Colon / pathology. Colonoscopy. Female. Humans. Immunohistochemistry. Male. Prospective Studies

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  • (PMID = 16254516.001).
  • [ISSN] 0277-2116
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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73. Vrettou E, Hytiroglou P, Sikas N, Soultoyannis I, Goodman ZD: Hepatic adenocarcinoma expressing inhibin in a young patient on oral contraceptives. Virchows Arch; 2005 May;446(5):560-5
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  • [Title] Hepatic adenocarcinoma expressing inhibin in a young patient on oral contraceptives.
  • A case of primary hepatic carcinoma is reported, which occurred in a 24-year-old woman with a 10-year history of oral contraceptive use, and demonstrated unique morphologic and immunohistochemical features.
  • The neoplastic cells were mostly arranged in trabecular and pseudoglandular growth patterns simulating hepatocellular carcinoma; however, in focal areas, small cystic, organoid and tubular patterns predominated.
  • [MeSH-major] Adenocarcinoma / diagnosis. Contraceptives, Oral, Combined / administration & dosage. Inhibins / analysis. Liver Neoplasms / diagnosis

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  • [Cites] Mod Pathol. 1998 Jul;11(7):656-64 [9688187.001]
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  • (PMID = 15815932.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Contraceptives, Oral, Combined; 0 / KRT7 protein, human; 0 / Keratin-7; 57285-09-3 / Inhibins; 68238-35-7 / Keratins
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74. Rong ZX, Fang CH, Zhu DJ, Liu SJ: [Expression of Smo protein and the downstream transcription factor Gli1 protein in Sonic hedgehog signal transduction pathway in gastric carcinoma]. Nan Fang Yi Ke Da Xue Xue Bao; 2006 Dec;26(12):1728-31
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  • [Title] [Expression of Smo protein and the downstream transcription factor Gli1 protein in Sonic hedgehog signal transduction pathway in gastric carcinoma].
  • OBJECTIVE: To study the expression of Smo protein and the downstream transcription factor Gli1 protein in Sonic hedgehog signal transduction pathway in gastric carcinoma.
  • METHODS: A tissue microarray was constructed using 85 gastric carcinoma and 25 normal gastric mucosa specimens.
  • The expression of Smo and Gli1 proteins were detected immunohistochemically and the correlation between their expression in gastric carcinoma was analyzed.
  • RESULTS: Only weak expression, if any, of Smo and Gli1 proteins was detected in normal gastric mucosa, but in papillary adenocarcinoma, tubular adenocarcinoma and poorly differentiated adenocarcinoma, their expressions were significant increased as the differentiation degree was lowered.
  • Smo protein expression in gastric carcinoma was significantly correlated with that of Gli1 protein with correlation coefficient of 0.989 (P<0.001).
  • CONCLUSION: The abnormal activity of Sonic hedgehog signal transduction pathway may play an important role in the occurrence of papillary adenocarcinoma, tubular adenocarcinoma and poorly differentiated adenocarcinoma, and this abnormality is associated with Smo protein overexpression, which upregulates the expression of the downstream transcription factor Gli1 protein.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / physiopathology. Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 17259107.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / GLI1 protein, human; 0 / Hedgehog Proteins; 0 / Receptors, G-Protein-Coupled; 0 / SMO protein, human; 0 / Transcription Factors
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75. Matsuda K, Kobayashi S, Yamashita M, Hirayama K, Kadosawa T, Taniyama H: Tubulopapillary carcinoma with spindle cell metaplasia of the mammary gland in a cat. J Vet Med Sci; 2008 May;70(5):479-81
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  • [Title] Tubulopapillary carcinoma with spindle cell metaplasia of the mammary gland in a cat.
  • Sarcomatous proliferation of spindle cells was present in the mammary gland and many metastatic sites in a 10-year-old female domestic cat with tubulopapillary carcinoma in the mammary gland.
  • Transition from neoplastic tubular structures to spindle cells in the primary site and fascicular proliferation of the spindle cells with or without coexistance of tubulopapillary carcinoma in the primary and metastatic sites were observed.
  • From these results, this case was diagnosed as tubulopapillary carcinoma with spindle cell metaplasia and it was clarified that neoplastic luminal epithelial cells can transform to sarcomatous appearence.

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  • (PMID = 18525170.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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76. Murphy SJ, Dickey W, Hughes D, O'Connor FA: Surveillance for Barrett's oesophagus: results from a programme in Northern Ireland. Eur J Gastroenterol Hepatol; 2005 Oct;17(10):1029-35
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  • BACKGROUND: The reported incidence of adenocarcinoma in patients with Barrett's oesophagus in surveillance programmes varies widely.
  • Barrett's oesophagus was defined as specialized intestinal metaplasia present in the tubular oesophagus.
  • Twenty-one patients had adenocarcinoma and two patients had high-grade dysplasia at initial endoscopy and were excluded.
  • Three patients developed adenocarcinoma, an incidence of 1/204 patient-years of follow-up.
  • CONCLUSIONS: The incidence of adenocarcinoma in patients in Northern Ireland was similar to the incidence reported by other large institutions.
  • [MeSH-major] Adenocarcinoma / diagnosis. Barrett Esophagus / diagnosis. Esophageal Neoplasms / diagnosis. Precancerous Conditions / diagnosis

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  • (PMID = 16148547.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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77. Zen Y, Fujii T, Itatsu K, Nakamura K, Minato H, Kasashima S, Kurumaya H, Katayanagi K, Kawashima A, Masuda S, Niwa H, Mitsui T, Asada Y, Miura S, Ohta T, Nakanuma Y: Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. Hepatology; 2006 Nov;44(5):1333-43
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  • In addition, biliary papillary tumors could be associated with two types of invasive lesions: tubular adenocarcinoma (9 cases) and mucinous carcinoma (5 cases).
  • Patients with tubular adenocarcinoma had a poor prognosis compared to non-invasive papillary tumor or papillary tumor with mucinous carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Pancreatic Neoplasms / pathology. Papilloma / pathology

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  • (PMID = 17058219.001).
  • [ISSN] 0270-9139
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Keratin-7; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucins
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78. Lynch HT, Grady W, Suriano G, Huntsman D: Gastric cancer: new genetic developments. J Surg Oncol; 2005 Jun 1;90(3):114-33; discussion 133
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  • It exhibits components of glandular, solid, or intestinal architecture, as well as tubular structures.
  • Patients with evidence of the CDH1 germline mutation in the context of a family history of HDGC must be considered as candidates for prophylactic gastrectomy, given the extreme difficulty in its early diagnosis and its exceedingly poor prognosis when there is regional or distant spread.
  • Specifically, the E-cadherin cytoplasmic tail interacts with catenins, assembling the cell-adhesion complex involved with E-cadherin mediated cell:cell adhesion.
  • This paper reviews the genetics of both intestinal and diffuse types of gastric carcinoma, their differential diagnosis, molecular genetics, pathology, and, when known, their mode of genetic transmission within families.
  • [MeSH-minor] Adenocarcinoma / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / surgery. Cytoskeletal Proteins / genetics. Female. Gastrectomy. Gastrointestinal Stromal Tumors / genetics. Genetic Counseling. Genetic Testing. Helicobacter Infections / complications. Helicobacter pylori. Humans. Male. Pedigree. Risk. Smoking / adverse effects. Trans-Activators / genetics. beta Catenin

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • (PMID = 15895459.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1U01 CA86389
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cadherins; 0 / Cytoskeletal Proteins; 0 / Trans-Activators; 0 / beta Catenin
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79. Kim TH, Kim JK, Jang EH, Lee JH, Kim YB: Papillary adenocarcinoma arising in a tubular duplication of the jejunum. Br J Radiol; 2010 Mar;83(987):e61-4
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  • [Title] Papillary adenocarcinoma arising in a tubular duplication of the jejunum.
  • In this report, we present the first case of papillary adenocarcinoma arising in a tubular duplication of the jejunum.
  • Coronal reformatted images from contrast-enhanced CT revealed a well-enhanced tubular mass in the distal jejunum with small bowel obstruction.
  • [MeSH-major] Adenocarcinoma, Papillary / radiography. Jejunal Neoplasms / radiography. Jejunum / abnormalities
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Image Processing, Computer-Assisted. Lymphatic Metastasis. Male. Mesenteric Artery, Superior. Tomography, X-Ray Computed / methods

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  • (PMID = 20197430.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3473542
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80. Balbinotti RA, Ribeiro U Jr, Sakai P, Safatle-Ribeiro AV, Balbinotti SS, Scapulatempo C, Alves VA, Corbett CE, Carrilho FJ: hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps. Anticancer Res; 2007 Nov-Dec;27(6C):4465-71
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  • PATIENTS AND METHODS: One hundred and sixty-seven colonic polyps, 6 normal colonic mucosa samples, and 23 samples of colorectal adenocarcinoma were used in this study.
  • RESULTS: Tubular adenomas were present in 81.4%, tubulous-villous in 15.9%, serrated in 1.8%, and villous in 0.9%.
  • Cox-2 expression was found in 9% of the adenomas, and in 40% of the adenocarcinomas.
  • Cox-2 is overexpressed in colorectal adenomatous polyps and adenocarcinomas, and its positivity in adenomas may indicate a higher risk for multiple lesions.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adult. Aged. Aged, 80 and over. Colorectal Neoplasms / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged. Rectum / pathology

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  • (PMID = 18214062.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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81. Kuwabara M, Wada K, Maeda Y, Miyazaki A, Tsunemitsu H: First isolation of cytopathogenic bovine torovirus in cell culture from a calf with diarrhea. Clin Vaccine Immunol; 2007 Aug;14(8):998-1004
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  • [Title] First isolation of cytopathogenic bovine torovirus in cell culture from a calf with diarrhea.
  • A cytopathogenic virus (designated the Aichi/2004 strain) was isolated in a human rectal adenocarcinoma cell line (HRT-18) from the ileum contents of a calf with diarrhea.
  • Oval and elongated particles, approximately 100 to 170 nm in diameter, with club-shaped projections were seen in the infected culture supernatant, and torovirus-like (tubular and torus nucleocapsid) structures were seen in the infected cells by electron microscopy.
  • Further, the isolate was positive for BToV by reverse transcription-PCR (RT-PCR) targeting fragments of the nucleocapsid (N), membrane (M), and spike (S) genes.
  • Comparison of the nucleotide sequences of the PCR products with those of the published N, M, and S genes (476 to 497, 672, and 687 to 690 nucleotides, respectively) of toroviruses showed high sequence identities (up to 99.4%, 98.7%, and 94.9% for the N, M, and S genes, respectively) between the isolate and BTovs. In contrast, the isolate was negative for BCV by RT-PCR.
  • [MeSH-minor] Animals. Antibodies, Viral / blood. Cattle. Cell Line. Cercopithecus aethiops. Cytopathogenic Effect, Viral. DNA, Viral / analysis. DNA, Viral / isolation & purification. Japan / epidemiology. Microscopy, Electron. Molecular Sequence Data. Sequence Analysis, DNA. Vero Cells. Viral Proteins / genetics

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  • (PMID = 17567770.001).
  • [ISSN] 1556-6811
  • [Journal-full-title] Clinical and vaccine immunology : CVI
  • [ISO-abbreviation] Clin. Vaccine Immunol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AB285125/ AB285126/ AB285127
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / DNA, Viral; 0 / Viral Proteins
  • [Other-IDs] NLM/ PMC2044491
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82. Nakanuma Y, Sato Y, Harada K, Sasaki M, Xu J, Ikeda H: Pathological classification of intrahepatic cholangiocarcinoma based on a new concept. World J Hepatol; 2010 Dec 27;2(12):419-27
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  • To date, ICC was largely classified into adenocarcinoma and rare variants.
  • The former is a tubular or micropapillary adenocarcinoma while the latter involves the intrahepatic large bile duct.
  • Hepatic progenitor cell or stem cell phenotypes such as neural cell adhesion molecule expression are frequently expressed in the bile ductular type.
  • Intraductal type includes papillary and tubular neoplasms of the bile duct (IPNBs and ITNBs) and a superficial spreading type.
  • IPNB and ITNB show a spectrum from a preneoplastic borderline lesion to carcinoma and may have pancreatic counterparts.
  • At invasive sites, IPNB is associated with the conventional bile duct ICC and mucinous carcinoma.
  • Rare variants of ICC include squamous/adenosquamous cell carcinoma, mucinous/signet ring cell carcinoma, clear cell type, undifferentiated type, neuroendocrine carcinoma and so on.

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  • (PMID = 21191517.001).
  • [ISSN] 1948-5182
  • [Journal-full-title] World journal of hepatology
  • [ISO-abbreviation] World J Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3010511
  • [Keywords] NOTNLM ; Adenocarcinoma / Bile duct / Bile ductule / Intraductal neoplasm / Intrahepatic cholangiocarcinoma
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83. Sanada Y, Hirose Y, Osada S, Tanaka Y, Takahashi T, Yamaguchi K, Yoshida K: Immunohistochemical study of claudin 18 involvement in intestinal differentiation during the progression of intraductal papillary mucinous neoplasm. Anticancer Res; 2010 Jul;30(7):2995-3003
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  • BACKGROUND AND AIM: A comparison was made between pancreatic ductal adenocarcinoma (PDAC), pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous carcinoma (IPMC) in order to understand the association between several markers and malignant potential.
  • P53 was positively stained in one of the 4 IPMCs in which minimally invasive tubular type carcinomas were observed.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / metabolism. Membrane Proteins / metabolism. Pancreatic Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Cell Differentiation / physiology. Claudins. Disease Progression. Humans. Immunohistochemistry. Intestines / pathology. Retrospective Studies

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  • (PMID = 20683045.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CLDN18 protein, human; 0 / Claudins; 0 / Membrane Proteins
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84. Sato Y, Ishii H, Terada T, Amaya S, Koizumi H, Fujisawa K, Munemoto Y, Mitsui T, Iida Y, Miura S: [A case of AFP-producing gastric cancer with hepatic metastases that accompanied early gastric cancer treated effectively by chemotherapy]. Gan To Kagaku Ryoho; 2010 Oct;37(10):1957-60
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  • Since the concurrence of AFP-producing gastric cancer and tubular adenocarcinoma is rare, and hepatic metastatic lesions disappeared, the case under study is considered to be of interest.

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  • (PMID = 20976991.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / alpha-Fetoproteins; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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85. Boets A, Van Steen A, Van Ongeval C, Drijkoningen R, Christiaens B: Familial tubular breast carcinoma. JBR-BTR; 2005 May-Jun;88(3):114-5
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  • [Title] Familial tubular breast carcinoma.
  • [MeSH-major] Adenocarcinoma / genetics. Breast Neoplasms / genetics

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  • (PMID = 16038219.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Belgium
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86. Takeo H, Matsukuma S: Gastric tube cancer: immunohistochemical study of 10 lesions in six patients. J Gastroenterol Hepatol; 2007 Jan;22(1):23-9
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  • BACKGROUND AND AIM: Gastric tube cancer (GTC), defined as carcinoma arising in the reconstructed gastric tube after esophagectomy, has been increasingly reported, but its pathogenesis remains unclear.
  • Nine GTCs had tubular and/or papillary adenocarcinoma components, and another was signet-ring cell carcinoma.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Signet Ring Cell / metabolism. Carcinoma, Signet Ring Cell / pathology. Carcinoma, Signet Ring Cell / surgery. Esophagectomy. Gastric Mucins / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Mucin 5AC. Mucins / metabolism. Phenotype. Reconstructive Surgical Procedures

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  • (PMID = 17201876.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Gastric Mucins; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins
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87. Singhi AD, Montgomery EA: Colorectal granular cell tumor: a clinicopathologic study of 26 cases. Am J Surg Pathol; 2010 Aug;34(8):1186-92
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  • [Title] Colorectal granular cell tumor: a clinicopathologic study of 26 cases.
  • Granular cell tumor (GCT) is commonly located in the subcutaneous tissue and oral cavity, and uncommon in the gastrointestinal tract, in which the majority arises in the esophagus with over-representation in African Americans (AA).
  • Some had reactive mucosal surface changes (7/20, 35%), including 1 initially misdiagnosed as a tubular adenoma.
  • [MeSH-major] Adenocarcinoma / pathology. Colon / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 20661017.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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88. Goetzl MA, Outman JE, Griebling TL, Holzbeierlein JM, Weigel JW, Thrasher JB: Digital fecal occult blood testing in the ambulatory urology clinic. J Am Coll Surg; 2008 Jan;206(1):144-7
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  • Two patients had benign lower gastrointestinal sources of bleeding, including one with hyperplastic polyps and one with a tubular adenoma.
  • One patient was diagnosed with a moderately differentiated adenocarcinoma of the sigmoid colon.
  • [MeSH-major] Colorectal Neoplasms / diagnosis. Digital Rectal Examination / methods. Outpatient Clinics, Hospital. Urology Department, Hospital

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  • (PMID = 18155580.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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89. Yang XJ, Zhou M, Hes O, Shen S, Li R, Lopez J, Shah RB, Yang Y, Chuang ST, Lin F, Tretiakova MM, Kort EJ, Teh BT: Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterization. Am J Surg Pathol; 2008 Feb;32(2):177-87
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  • [Title] Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterization.
  • The nature of tubulocystic carcinoma, a rare renal tumor composed of tubular and cystic structures, is poorly understood.
  • It has been suggested that it may represent a low-grade collecting duct carcinoma of the kidney despite the lack of sufficient molecular and pathologic evidence.
  • The aim of this study was to examine the clinical and pathologic features of 13 cases of tubulocystic carcinoma of the kidney.
  • Five of the 13 cases coexisted with papillary renal cell carcinoma (RCC) (n=3) or papillary adenoma (n=2).
  • In addition, the molecular profile of tubulocystic carcinoma was similar but not identical to those of papillary RCC by clustering analysis.
  • Through comparative genomic microarray analysis, tubulocystic carcinoma showed gains of chromosome 17, but not chromosome 7, whereas most papillary RCCs showed chromosomal gains in both 7 and 17 (trisomies).
  • Therefore, based on its unique pathologic features and molecular signature as well as its biologic behavior to develop metastasis either by itself or in association with papillary RCC, tubulocystic carcinoma of the kidney should be recognized as a distinct subtype of RCC and be distinguished from other malignant and benign cystic lesions of the kidney.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Renal Cell / secondary. Chromosome Aberrations. Cystadenocarcinoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18223319.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Waraya M, Yamashita K, Katagiri H, Ishii K, Takahashi Y, Furuta K, Watanabe M: Preoperative serum CA19-9 and dissected peripancreatic tissue margin as determiners of long-term survival in pancreatic cancer. Ann Surg Oncol; 2009 May;16(5):1231-40
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  • PATIENTS AND METHODS: 117 patients with pancreatic ductal carcinoma, including 89 with invasive tubular adenocarcinoma of the pancreas, Japan Pancreas Society (JPS) stage III-IVb patients, who underwent tumor resection between 1986 and 2006.
  • CONCLUSION: Our results reveal for the first time that it is possible with JPS stage III-IVb invasive tubular adenocarcinomas of the pancreas to differentiate prognostic groups and potential survival rates, like with other cancers.
  • [MeSH-major] Adenocarcinoma / mortality. CA-19-9 Antigen / blood. Carcinoma, Pancreatic Ductal / mortality. Pancreatic Neoplasms / mortality

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  • (PMID = 19263172.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
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91. Mainenti PP, Salvatore B, D'Antonio D, De Falco T, De Palma GD, D'Armiento FP, Bucci L, Pace L, Salvatore M: PET/CT colonography in patients with colorectal polyps: a feasibility study. Eur J Nucl Med Mol Imaging; 2007 Oct;34(10):1594-603
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  • RESULTS: Seventeen polypoid lesions were identified at CC: six< or =5 mm, six between 6 and 9 mm, and five > or =10 mm (four hyperplastic polyps, 11 tubular adenomas, one adenocarcinoma and one submucosal lipoma).
  • [MeSH-major] Colonic Polyps / diagnosis. Colonography, Computed Tomographic / methods. Colorectal Neoplasms / diagnosis. Image Enhancement / methods. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 17492447.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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92. Grieco V, Locatelli C, Riccardi E, Brambilla P: A case of two different tumors in the heart of a dog. J Vet Diagn Invest; 2008 May;20(3):365-8
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  • A 9-year-old, spayed, female Maremmano shepherd had a bilateral mastectomy for multiple mammary adenocarcinomas 2 years previous and was referred to the Cardiology Service of the School of Veterinary Medicine of Milan after an acute episode of cardiogenic collapse.
  • Histological examination revealed the coexistence of tubular adenocarcinoma and an undifferentiated sarcoma in the myocardium.
  • To the authors' knowledge, this is the first report describing cardiac sarcoma of presumptive myofibroblastic origin in a dog with simultaneous occurrence of cardiac metastasis of mammary gland adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / veterinary. Dog Diseases / diagnosis. Heart Neoplasms / veterinary. Sarcoma / veterinary

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  • (PMID = 18460629.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Díaz-Sánchez A, Núñez-Martínez O, González-Asanza C, Matilla A, Merino B, Beceiro I, Ponferrada A, Bañares R, Clemente G, Menchén PL: [Results of colonoscopic examination in the evaluation of cirrhotic candidates for liver transplantation]. Gastroenterol Hepatol; 2009 May;32(5):327-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Polyps were discovered in 38% (35/92) of patients (adenomatous 65.2%; tubular type 86.7%).
  • Six patients with adenomatous polyps had mild dysplasia, and one asymptomatic patient had a well-differentiated adenocarcinoma.
  • [MeSH-major] Colonic Diseases / complications. Colonic Diseases / diagnosis. Colonoscopy. Liver Cirrhosis / complications. Liver Transplantation


94. Manfrin E, Falsirollo F, Remo A, Reghellin D, Mariotto R, Dalfior D, Piazzola E, Bonetti F: Cancer size, histotype, and cellular grade may limit the success of fine-needle aspiration cytology for screen-detected breast carcinoma. Cancer; 2009 Dec 25;117(6):491-9
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  • [Title] Cancer size, histotype, and cellular grade may limit the success of fine-needle aspiration cytology for screen-detected breast carcinoma.
  • The underestimation of malignancy rate was higher in tubular carcinoma (18.2%); lobular carcinoma showed a higher inadequacy rate (10.4%).
  • The sensitivity rate was lower and the underestimation of malignancy rate was higher in low-grade carcinomas and in lesions <1 cm (P < .001).
  • CONCLUSIONS: Low-grade cancer histotype, cancer size <1 cm, and lobular and tubular histotypes limit the possibility of obtaining positive results by FNAC.

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  • [Copyright] (c) 2009 American Cancer Society.
  • (PMID = 19806645.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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95. Chlumská A, Boudová L, Zámecník M: Sessile serrated adenomas of the large bowel. Clinicopathologic and immunohistochemical study including comparison with common hyperplastic polyps and adenomas. Cesk Patol; 2006 Jul;42(3):133-8
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  • It arises in hyperplastic polyp (HP) and represents a precursor lesion of colorectal carcinoma with microsatellite instability.
  • For comparison, we examined 10 conventional tubular adenomas and 10 common HPs with vesicular cells.
  • The sites of SSAs were as follows: 8 in rectum, 4 in rectosigmoid colon, 1 in transverse colon, 1 next to mucinous carcinoma of ascending colon, 1 in anastomosis after resection of the transverse colon adenocarcinoma.
  • High-grade dysplasia was found only in SSA adjacent to mucinous adenocarcinoma.
  • Both MUC2 and MUC5A were also positive in mucinous carcinoma.
  • SSAs have malignant potential comparable with conventional adenomas and for this reason they must be distinguished from HPs.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoma / pathology. Colonic Polyps / chemistry. Colonic Polyps / pathology. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucin 5AC. Mucin-2. Mucins / analysis. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16955561.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucins
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96. Bretz-Grenier MF: [Breast cytopathology bestiary]. Ann Pathol; 2006 Oct;26(5):403-8
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  • Breast cytopathology of tubular and lobular carcinomas may be very difficult.
  • Indeed, the classical morphological signs of malignancy are often scarce or absent; the identification of special patterns of cell clusters may therefore be very useful to reach a diagnosis.
  • [MeSH-minor] Adenocarcinoma / pathology. Carcinoma, Lobular / pathology. Diagnosis, Differential. Female. Humans

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  • (PMID = 17255930.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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97. Schröder W, Vallböhmer D, Bludau M, Banczyk A, Gutschow C, Hölscher AH: The resection of the azygos vein--necessary or redundant extension of transthoracic esophagectomy? J Gastrointest Surg; 2008 Jul;12(7):1163-7
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  • Ninety-two patients with esophageal carcinoma were included in this prospective analysis.
  • After resection, the azygos vein with its adjacent connective tissue was separated from the tubular esophagus.
  • [MeSH-minor] Abdomen. Adenocarcinoma / blood supply. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Carcinoma, Squamous Cell / blood supply. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Treatment Outcome

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  • [CommentIn] J Gastrointest Surg. 2008 Dec;12(12):2246-7; author reply 2248 [18677537.001]
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  • (PMID = 18278537.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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98. Kiu V, Wang HP, Wu YM: Cystic duct tubular adenocarcinoma. Dig Surg; 2009;26(5):369-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic duct tubular adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Cystic Duct / pathology

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  • (PMID = 19923822.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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99. Hasuo T, Semba S, Satake S, Shirasaka D, Aoyama N, Yokozaki H: Superficially elevated-type serrated hyperplastic lesion of the stomach with minute adenocarcinoma. Dig Endosc; 2009 Apr;21(2):101-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Superficially elevated-type serrated hyperplastic lesion of the stomach with minute adenocarcinoma.
  • We report a case of gastric serrated hyperplastic lesion with minute adenocarcinoma.
  • Histological observation revealed hyperplastic change of foveolar epithelium with serrated glandular structure as well as a minute tubular adenocarcinoma component.
  • Positive p53 immunoreactivity was detected in the carcinoma component of the lesion with a point mutation (G877T; R209I) of the gene and microsatellite instability of the BAT-RII locus; however, immunoreactivity of the mismatch repair gene product hMLH1 was well preserved in the cancer as well as in the hyperplastic lesion.
  • The hyperplastic lesion with serrated glandular pattern would be a precancerous lesion of adenocarcinoma of the stomach.
  • [MeSH-major] Adenocarcinoma / pathology. Stomach Neoplasms / pathology

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  • (PMID = 19691783.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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100. Dotto J, Kluk M, Geramizadeh B, Tavassoli FA: Frequency of clinically occult intraepithelial and invasive neoplasia in reduction mammoplasty specimens: a study of 516 cases. Int J Surg Pathol; 2008 Jan;16(1):25-30
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  • Among these, 92 (18%) low-risk ductal intraepithelial neoplasia/intraductal hyperplasia, 28 (5%) ductal intraepithelial neoplasia 1 (1 low-grade ductal carcinoma in situ, 11 atypical intraductal hyperplasia, and 16 flat type), 17 (3%) lobular intraepithelial neoplasia, and 1 (0.2%) tubular carcinoma were identified.

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  • (PMID = 18203780.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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