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1. Trifan A, Singeap AM, Cojocariu C, Sfarti C, Tarcoveanu E, Georgescu S: Single-balloon enteroscopy following videocapsule endoscopy for diagnosis of small bowel tumors: preliminary experiences. Chirurgia (Bucur); 2010 Mar-Apr;105(2):211-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Single-balloon enteroscopy following videocapsule endoscopy for diagnosis of small bowel tumors: preliminary experiences.
  • BACKGROUND AND AIM: Small bowel tumors (SBTs), either benign or malignant, are rare, accounting for 3-6% of all digestive neoplasms.
  • Videocapsule endoscopy (VCE) and double-balloon enteroscopy (DBE) have revolutionized the diagnosis and management of patients with small bowel diseases, including SBTs.
  • There were two gastrointestinal stromal tumors and one adenocarcinoma.
  • VCE should be used first for initial diagnosis, followed by SBE for histopathological confrmation of the diagnosis and, if necessary, endoscopic therapy.
  • [MeSH-minor] Adult. Diagnosis, Differential. Endoscopy, Gastrointestinal / methods. Equipment Design. Female. Humans. Intestine, Small / pathology. Male. Middle Aged. Reproducibility of Results. Risk Assessment. Sensitivity and Specificity

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  • (PMID = 20540234.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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2. Gonda TA, Khan SU, Cheng J, Lewis SK, Rubin M, Green PH: Association of intussusception and celiac disease in adults. Dig Dis Sci; 2010 Oct;55(10):2899-903
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  • Two patients were found to have lead-point intussusceptions and both had small-bowel adenocarcinoma, and 10/14 had severe villous atrophy (subtotal or total).
  • Among those with established celiac disease, IS was detected early, within 3 years of diagnosis.
  • Adenocarcinoma needs to be excluded.
  • [MeSH-minor] Abdominal Pain / epidemiology. Abdominal Pain / pathology. Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adult. Atrophy. Biopsy. Capsule Endoscopy. Chi-Square Distribution. Databases, Factual. Female. Follow-Up Studies. Humans. Incidental Findings. Intestinal Neoplasms / epidemiology. Intestinal Neoplasms / pathology. Male. Middle Aged

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  • (PMID = 20033844.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. Manfredi S, Thiebot T, Henno S, Falize L, Bretagne JF, Meunier B: Complete response of an initially non-surgical adenocarcinoma of the duodenum to chemotherapy with the FOLFOX 4 regimen. J Gastrointest Surg; 2009 Dec;13(12):2309-13
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  • [Title] Complete response of an initially non-surgical adenocarcinoma of the duodenum to chemotherapy with the FOLFOX 4 regimen.
  • INTRODUCTION: The incidence of adenocarcinoma of the small bowel is very low in comparison with that of colorectal cancer.
  • No standard chemotherapy is defined for non-surgical adenocarcinoma of the small bowel.
  • CASE REPORT: We report here the case of a young patient with an initially non-surgical adenocarcinoma of the duodenum treated in a palliative setting with the FOLFOX 4 chemotherapy regimen.
  • CONCLUSION: The FOLFOX 4 regimen seems to be efficacious for some small-bowel adenocarcinomas and can be expected to lead to downstaging.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy

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  • (PMID = 19585173.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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4. Fujimori S, Ehara A, Seo T, Mitsui K, Sakamoto C: [Primary small intestinal malignant tumors]. Nihon Rinsho; 2008 Jul;66(7):1286-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary small intestinal malignant tumors].
  • Small intestinal primary adenocarcinomas, carcinoids, gastrointestinal stromal tumors (GISTs) were cleared up inadequately because it was hard to examine for small intestine by modalities in the 20th century.
  • We attempt to present these small intestinal malignant tumors using by capsule endoscopy and double balloon endoscopy.
  • [MeSH-major] Adenocarcinoma. Carcinoid Tumor. Gastrointestinal Stromal Tumors. Intestinal Neoplasms. Intestine, Small

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  • (PMID = 18616119.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 30
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5. Tan KY, Moriya Y, Konishi F: Multimedia articles. Small-bowel tumors with extensive mesenteric involvement can be resected with careful dissection of the mesenteric vessels with good outcomes. Dis Colon Rectum; 2009 Jun;52(6):1184-5
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  • [Title] Multimedia articles. Small-bowel tumors with extensive mesenteric involvement can be resected with careful dissection of the mesenteric vessels with good outcomes.
  • We show the video of the dissection and resection of a locally advanced jejunal adenocarcinoma, with the involvement of multiple loops, to the base of the mesentery.
  • Complete resection was made possible by careful dissection of the jejunal vessels and superior mesenteric artery at the root of the small-bowel mesentery (see Video, Supplemental Digital Content 1, http://links.lww.com/A1308).
  • [MeSH-major] Adenocarcinoma / surgery. Intestinal Neoplasms / surgery. Intestine, Small. Mesentery / surgery

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  • (PMID = 19581866.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Ohnishi N, Yuasa H, Tanaka S, Sawa H, Miura M, Matsui A, Higashi H, Musashi M, Iwabuchi K, Suzuki M, Yamada G, Azuma T, Hatakeyama M: Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A; 2008 Jan 22;105(3):1003-8
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  • Infection with cagA-positive Helicobacter pylori is associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma of B cell origin.
  • Wild-type CagA transgenic mice showed gastric epithelial hyperplasia and some of the mice developed gastric polyps and adenocarcinomas of the stomach and small intestine.

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  • (PMID = 18192401.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Bacterial; 0 / Bacterial Proteins; 0 / cagA protein, Helicobacter pylori; 21820-51-9 / Phosphotyrosine
  • [Other-IDs] NLM/ PMC2242726
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7. Caruso S, Marrelli D, Pedrazzani C, Neri A, Mazzei MA, Onorati M, Corso G, Cerullo G, Roviello F: A rare case of primary small bowel adenocarcinoma with intussusception. Tumori; 2010 Mar-Apr;96(2):355-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of primary small bowel adenocarcinoma with intussusception.
  • In contrast with the colon tract, the incidence of primary malignancies in the small bowel is very low.
  • We report the case of a 51-year-old man presenting with jejunal intussusception due to a primary adenocarcinoma.
  • The patient was referred to our division for bowel obstruction.
  • Histological examination of the specimen resulted in a diagnosis of a primary adenocarcinoma of the small bowel.
  • In adult intestinal intussusception, resection without reduction is considered the optimal management if an underlying primary malignancy cannot be excluded.
  • [MeSH-major] Adenocarcinoma / complications. Intussusception / etiology. Jejunal Diseases / etiology. Jejunal Neoplasms / complications

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  • (PMID = 20572601.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Patel S, Liu D, Caron P, Seiter K: Acute myelogenous leukemia following irinotecan-based chemotherapy for adenocarcinoma of the small intestine. Leuk Lymphoma; 2007 May;48(5):1032-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute myelogenous leukemia following irinotecan-based chemotherapy for adenocarcinoma of the small intestine.
  • [MeSH-major] Adenocarcinoma / drug therapy. Camptothecin / analogs & derivatives. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology. Leukemia, Myeloid, Acute / drug therapy

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  • (PMID = 17487750.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; IFL protocol
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9. Nakamura K, Higashi T, Yamada M, Imai K, Yamamoto Y: Basophilic intracytoplasmic viral matrix inclusions distributed widely in layer hens affected with avian-leukosis-virus-associated tumours. Avian Pathol; 2007 Feb;36(1):53-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Basopholic intracytoplasmic viral matrix inclusions (MIs) were widely distributed in the chickens affected with subcutaneous myxoma rhabdomyosarcoma, perineuroma, glioma, intra-abdominal adenocarcinoma, and nephroblastoma.
  • They were also present in the smooth muscle cells of the arteries in the spleen and lungs, in the smooth muscle of the digestive tract muscular layer (crop, oesophagus, proventriculus, gizzard, duodenum, jejunum, ileum, caecum, and large intestine), and in the smooth muscle of the capsule in the ovary and pancreas.
  • They consisted of electron-dense small granules and ring-shaped particles.

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  • (PMID = 17364510.001).
  • [ISSN] 0307-9457
  • [Journal-full-title] Avian pathology : journal of the W.V.P.A
  • [ISO-abbreviation] Avian Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Thomsen Lønborg J, Vilmar A, Mård D, Astrup Jensen S, Sørensen JB: Prognosis of small bowel adenocarcinoma treated with Mayo or Xelox regimen: a matched case-control study from a database of 581 patients with colorectal cancer. Oncol Rep; 2007 Oct;18(4):1023-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognosis of small bowel adenocarcinoma treated with Mayo or Xelox regimen: a matched case-control study from a database of 581 patients with colorectal cancer.
  • The purpose of this study was to compare the effects of chemotherapy on the prognosis for patients with adenocarcinoma of the small bowel (SBC) and colorectal cancer (CRC).
  • However, reliable conclusions cannot be drawn from a small patient population, and multicentre studies are needed.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colorectal Neoplasms / drug therapy. Intestine, Small / drug effects

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  • (PMID = 17786369.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Organoplatinum Compounds; 0W860991D6 / Deoxycytidine; U3P01618RT / Fluorouracil; XELOX
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11. Sugimoto Y, Semba H, Fujii S, Furukawa E, Kurano R: [Clinical analysis of primary lung cancer with a thin-walled cavity to explain the mechanism of thin-walled cavity formation]. Nihon Kokyuki Gakkai Zasshi; 2007 Jun;45(6):460-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The reason for detection was treatment for tuberculosis in 1 case, ileus owing to metastasis to the small intestine in 1 case and tension pnumathorax 1 case, while 5 cases had abnormal chest x-ray film shadows without symptoms.
  • Histologically, there were 5 cases of adenocarcinoma, 2 of squamous cell carcinoma, and 1 of adenosquamous cell carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / radiography. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / radiography. Carcinoma, Squamous Cell / radiography. Lung Neoplasms / pathology. Lung Neoplasms / radiography

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  • (PMID = 17644941.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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12. Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ: Small bowel adenocarcinoma. Curr Treat Options Oncol; 2008 Dec;9(4-6):388-99
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  • [Title] Small bowel adenocarcinoma.
  • Small bowel cancers are rare, accounting for only about 6000 cases/year in the United States, approximately 25% of which are small bowel adenocarcinomas.
  • Small bowel adenocarcinomas have traditionally been considered to be highly fatal due to their nonspecific presentation at the time of diagnosis, and to the lack of responsiveness to older chemotherapy regimens.
  • Newer diagnostic techniques such as video capsule and double balloon enteroscopy may facilitate earlier diagnosis.
  • Still, there remains great need for multi-institutional, cooperative group studies to define the optimal treatment of small bowel adenocarcinoma, both in the adjuvant and advanced/metastatic setting.
  • [MeSH-major] Adenocarcinoma / epidemiology. Intestinal Neoplasms / epidemiology
  • [MeSH-minor] Age of Onset. Animals. Antimetabolites, Antineoplastic / therapeutic use. Disease Models, Animal. Female. Fluorouracil / therapeutic use. Humans. Intestine, Small / pathology. Male. Mice. Middle Aged. Neoplasm Staging. Prognosis. Risk Factors. United States / epidemiology

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  • (PMID = 19365735.001).
  • [ISSN] 1534-6277
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
  • [Number-of-references] 40
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13. Li S, Li Y, Tang L, Zhao P: Obstructed small bowel ruptured toward the inguinal canal resulting from metastatic colon carcinoma in an irreducible, recurrent inguinal hernia with mesh-plug repair: Report of a case. Eur J Surg Oncol; 2010 Oct;36(10):1012-4
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  • [Title] Obstructed small bowel ruptured toward the inguinal canal resulting from metastatic colon carcinoma in an irreducible, recurrent inguinal hernia with mesh-plug repair: Report of a case.
  • Delayed surgical exploration revealed metastatic cancer with small bowel adhesion to the mesh-plug and perforation.
  • The mesh-plug with adherent tissue was removed through the inguinal incision, and the ruptured small bowel was resected.
  • Histopathology revealed moderately differentiated mucinous adenocarcinoma of the tissue adhering to the prosthetic material corresponding to the original colon cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Hernia, Inguinal / surgery. Intestinal Obstruction / pathology. Intestine, Small / surgery. Sigmoid Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20138732.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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14. Bruna M, Galindo P, Roig JV, Salvador A, Ismail A, García Fadrique A: [Primary small bowel adenocarcinoma de novo]. Rev Esp Enferm Dig; 2006 Oct;98(10):796-7
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  • [Title] [Primary small bowel adenocarcinoma de novo].
  • [Transliterated title] Adenocarcinoma primitivo de intestino delgado con presentación de novo.
  • [MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small

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  • (PMID = 17094734.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Letter
  • [Publication-country] Spain
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15. Tankova L, Berberova M, Damianov N, Tsankov Ts, Kovatchki D: Preoperative diagnosis of jejunal adenocarcinoma--a case report. J BUON; 2008 Jan-Mar;13(1):123-6
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  • [Title] Preoperative diagnosis of jejunal adenocarcinoma--a case report.
  • We report herein the case of a preoperatively diagnosed small bowel adenocarcinoma.
  • An US-guided fine (20 gauge) needle aspiration (FNA) cytology of the mass was performed and showed moderately differentiated adenocarcinoma of intestinal origin.
  • On surgical exploration a jejunal tumor of high consistency was found, located 15 cm distantly from the Treitz ligament, infiltrating up to 2/3 of the bowel circumference and partly obstructing its lumen.
  • The histological evaluation of the resected material showed highly to moderately differentiated adenocarcinoma with 5 regional lymph node metastases.
  • The combination of US with Doppler and FNA established preoperatively the malignant small bowel disease.
  • [MeSH-major] Adenocarcinoma / diagnosis. Jejunal Neoplasms / diagnosis

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  • (PMID = 18404799.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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16. Yu QS, Liu Y, Hou Y, Zhang F, Yi W, Wang X, Shuai J: [Effect of early intestinal dripping of jianpi tongli Chinese herbs on serum level IL-2, sIL-2R and IL-12 in patients with gastric cancer after operation]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2005 Aug;25(8):710-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effect of early intestinal dripping of jianpi tongli Chinese herbs on serum level IL-2, sIL-2R and IL-12 in patients with gastric cancer after operation].
  • OBJECTIVE: To explore the regulation and clinical significance of intestinal dripping of Jianpi Tongli (JPTL) Chinese herbs on levels of serum cytokines, such as interleukin-2 (IL-2), soluble interleukin-2 receptor (sIL-2R) and interleukin-12 (IL-12) in treating patients with gastric cancer (GC) at early post-operational stage.
  • The medication was started from the 1st day after operation by intestinal dripping daily, 7 days as one course.
  • CONCLUSION: Early intestinal dripping of JPTL Chinese herbs to post-operational patients with GC could improve their immune function, which was of important significance in early preventing the severe complications, improving the prognosis, and elevating the survival rate.

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  • (PMID = 16152828.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Interleukin-2; 0 / Receptors, Interleukin-2; 187348-17-0 / Interleukin-12
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17. Zaanan A, Afchain P, Carrere N, Aparicio T: [Small bowel adenocarcinoma]. Gastroenterol Clin Biol; 2010 Aug-Sep;34(6-7):371-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Small bowel adenocarcinoma].
  • [Transliterated title] Adénocarcinome de l'intestin grêle.
  • Small bowel adenocarcinoma is a rare tumor.
  • Diagnosis is usually performed at an advanced stage because of non-specific nature of clinical manifestations.
  • New methods of radiological and endoscopic exploration of small intestine should allow earlier diagnosis.
  • A national prospective cohort study is currently evaluating the results of chemotherapy (recommended protocol: FOLFOX) as adjuvant and palliative treatment of small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Adenocarcinoma / therapy. Intestinal Neoplasms / etiology. Intestinal Neoplasms / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Genetic Predisposition to Disease. Humans. Intestine, Small / pathology. Intestine, Small / surgery. Lymphatic Metastasis. Neoplasm Metastasis. Prognosis. Risk Factors

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20537487.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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18. Bowen JM, Gibson RJ, Cummins AG, Tyskin A, Keefe DM: Irinotecan changes gene expression in the small intestine of the rat with breast cancer. Cancer Chemother Pharmacol; 2007 Feb;59(3):337-48
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  • [Title] Irinotecan changes gene expression in the small intestine of the rat with breast cancer.
  • CONCLUSIONS: This study has identified MAP kinase signalling as being involved with irinotecan-induced intestinal damage and confirms previous findings with radiation-induced oral mucosal damage, which also implicated this pathway.
  • [MeSH-major] Adenocarcinoma / genetics. Antineoplastic Agents, Phytogenic / pharmacology. Camptothecin / analogs & derivatives. Gene Expression Regulation, Neoplastic / drug effects. Jejunum / drug effects. Mammary Neoplasms, Experimental / genetics

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  • (PMID = 16799812.001).
  • [ISSN] 0344-5704
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / RNA, Messenger; 7673326042 / irinotecan; EC 2.7.12.2 / Mitogen-Activated Protein Kinase Kinases; EC 3.4.22.36 / Caspase 1; XT3Z54Z28A / Camptothecin
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19. Beetham M, Khan MI: Incarceration of an umbilical hernia following colonoscopy. N Z Med J; 2009 Dec 11;122(1307):97-9
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  • We describe the unique case of a patient who developed incarceration of a loop of small bowel in an umbilical hernia following an uneventful diagnostic colonoscopy.
  • It was treated with laparotomy, with release of the incarcerated bowel and closure of the defect with nylon sutures.
  • [MeSH-major] Colonoscopy / adverse effects. Hernia, Umbilical / complications. Intestinal Obstruction / etiology. Intestinal Obstruction / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / ultrasonography. Aged. Anemia, Iron-Deficiency / diagnosis. Anemia, Iron-Deficiency / etiology. Colonic Neoplasms / diagnosis. Colonic Neoplasms / surgery. Female. Follow-Up Studies. Humans. Intestinal Volvulus. Intestine, Small / pathology. Laparotomy / methods. Risk Assessment. Treatment Outcome

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  • (PMID = 20148050.001).
  • [ISSN] 1175-8716
  • [Journal-full-title] The New Zealand medical journal
  • [ISO-abbreviation] N. Z. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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20. Bulfoni A: [Primary adenocarcinoma of jejunum with obscure gastrointestinal bleeding]. Clin Ter; 2006 Sep-Oct;157(5):431-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary adenocarcinoma of jejunum with obscure gastrointestinal bleeding].
  • [Transliterated title] Adenocarcinoma primitivo del digiuno ad esteriorizzazione con enterorragia.
  • A case of primary small bowel adenocarcinoma is reported because of the rarity of this malignancy.
  • [MeSH-major] Adenocarcinoma. Gastrointestinal Hemorrhage / etiology. Jejunal Neoplasms
  • [MeSH-minor] Capsule Endoscopy. Diagnosis, Differential. Female. Humans. Jejunum / pathology. Middle Aged. Occult Blood. Prognosis

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  • (PMID = 17147051.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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21. Policarpio-Nicolas ML, Nicolas MM, Keh P, Laskin WB: Postradiation angiosarcoma of the small intestine: a case report and review of literature. Ann Diagn Pathol; 2006 Oct;10(5):301-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postradiation angiosarcoma of the small intestine: a case report and review of literature.
  • Postradiation angiosarcoma arising in the small intestine is rare with only 11 cases documented in the English-language literature.
  • Herein, we report a postradiation angiosarcoma of the small intestine 9 years after radiotherapy for uterine cervical adenocarcinoma.
  • The patient presented with symptoms of intestinal obstruction.
  • At exploratory laparotomy, tumor nodules involved the small bowel.
  • The diagnosis of angiosarcoma was confirmed immunohistochemically by tumor cell expression of CD31, CD34, and factor VIII-related antigen.
  • The diagnosis of PRA should be entertained for any poorly differentiated neoplasm arising in a previously irradiated site.
  • The correct diagnosis of PRA depends upon histomorphologic identification of vascular differentiation, coupled with immunohistochemical expression of endothelial-related markers.
  • [MeSH-major] Hemangiosarcoma / etiology. Intestinal Neoplasms / etiology. Intestine, Small. Neoplasms, Radiation-Induced / diagnosis
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Antigens, CD31 / metabolism. Antigens, CD34 / metabolism. Cell Transformation, Neoplastic / pathology. Factor VIII / metabolism. Fatal Outcome. Female. Gene Expression Regulation, Neoplastic. Humans. Intestinal Obstruction / etiology. Middle Aged. Prognosis. Uterine Cervical Neoplasms / radiotherapy

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  • (PMID = 16979525.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 9001-27-8 / Factor VIII
  • [Number-of-references] 17
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22. Maran RR, Thomas A, Roth M, Sheng Z, Esterly N, Pinson D, Gao X, Zhang Y, Ganapathy V, Gonzalez FJ, Guo GL: Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development. J Pharmacol Exp Ther; 2009 Feb;328(2):469-77
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  • [Title] Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development.
  • FXR is highly expressed in the intestine and liver where FXR is essential for maintaining bile acid homeostasis.
  • The role of FXR in intestine cancer development is not known.
  • The current study evaluated the effects of FXR deficiency in mice on intestinal cell proliferation and cancer development.
  • Most importantly, FXR deficiency led to an increase in the size of small intestine adenocarcinomas in adenomatous polyposis coli mutant mice.
  • Furthermore, after treatment with a colon carcinogen, azoxymethane, FXR deficiency increased the adenocarcinoma multiplicity and size in colon and rectum of C57BL/6 mice.
  • Loss of FXR function also increased the intestinal lymphoid nodule numbers in the intestine.
  • Taken together, the current study is the first to show that FXR deficiency promotes cell proliferation, inflammation, and tumorigenesis in the intestine, suggesting that activation of FXR by nonbile acid ligands may protect against intestinal carcinogenesis.

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  • (PMID = 18981289.001).
  • [ISSN] 1521-0103
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / K12-HD052027; United States / Intramural NIH HHS / / ; United States / NICHD NIH HHS / HD / K12 HD052027; United States / NCRR NIH HHS / RR / P20-RR015563; United States / NCRR NIH HHS / RR / P20-RR021940; United States / NIDDK NIH HHS / DK / R01-DK81343
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Orphan Nuclear Receptors; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Transcription Factors; 0 / farnesoid X-activated receptor; 0 / liver X receptor; MO0N1J0SEN / Azoxymethane
  • [Other-IDs] NLM/ PMC2682273
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23. Parfenov AI, Krums LM, Sivash ES, Tsaregorodtseva TM, Poleva NI, Ruchkina IN, Sabel'nikova EA, Chikunova BZ: [Algorithm for diagnosis of small intestinal diseases]. Ter Arkh; 2008;80(4):46-51
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  • [Title] [Algorithm for diagnosis of small intestinal diseases].
  • AIM: To review diagnostic approaches in chronic diseases of the small intestine.
  • MATERIAL AND METHODS: A total of 1096 patients with chronic diseases of the small intestine were admitted to the clinic of the Central Research Institute of Gastroenterological Diseases in 1987-2006.
  • RESULTS: Most of the patients (90.5%) had celiac disease, hypolactasia and other types of disaccharidase deficiency, yersiniosis ileitis, Krohn's disease, postresection syndrome of a short small intestine, mesenterial ischemia and endocrine enteropathy.
  • Rare diseases (general variable hypogammaglobulinemia, lymphoma, Wipple's disease and diverticulosis of the small intestine) were diagnosed in 5.8% cases.
  • Primary amyloidosis of the small intestine, eosinophilic gastroenteritis, arteriomesenterial obstruction, primary intestinal pseudoobstruction, hypogammaglobulinemic spru, primary intestinal lymphangiectasia, tuberculosis, total polyposis, Peutz-Eggers and Cronkhite-Canada syndromes, collagenic sprue, erosive-ulcerative jejunoileitis, adenocarcinoma and heavy alpha-chain disease were detected in 3.7% examinees.
  • CONCLUSION: Clinical diagnosis of small intestinal diseases is based on the syndromes of chronic diarrhea, defective absorption, enteral protein loss, small intestinal obstruction and intestinal hemorrhage.
  • Differential diagnosis of the nosological entities employs x-ray, endoscopic, histological, immunological and other methods.
  • Most of the small intestinal diseases including rare can be diagnosed in any gastroentorological department.
  • [MeSH-major] Algorithms. Endoscopy, Gastrointestinal / methods. Immunologic Tests / methods. Intestinal Diseases / diagnosis. Intestine, Small. Radiography, Abdominal / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18491580.001).
  • [ISSN] 0040-3660
  • [Journal-full-title] Terapevticheskiĭ arkhiv
  • [ISO-abbreviation] Ter. Arkh.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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24. Liu WH, Zhou XG: [CD30-positive of diffuse large B-cell lymphoma of small intestine co-existing with tubular adenocarcinoma of rectum: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2007 Sep;36(9):641-2
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  • [Title] [CD30-positive of diffuse large B-cell lymphoma of small intestine co-existing with tubular adenocarcinoma of rectum: report of a case].
  • [MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasms, Multiple Primary / pathology. Rectal Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD30 / metabolism. Humans. Intestine, Small. Male

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  • (PMID = 18070460.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD30
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25. Chen ZM, Ritter JH, Wang HL: Differential expression of alpha-methylacyl coenzyme A racemase in adenocarcinomas of the small and large intestines. Am J Surg Pathol; 2005 Jul;29(7):890-6
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  • [Title] Differential expression of alpha-methylacyl coenzyme A racemase in adenocarcinomas of the small and large intestines.
  • Alpha-methylacyl coenzyme A racemase (AMACR), a novel immunomarker for prostatic adenocarcinoma, has recently been shown to be expressed in a number of malignancies including colorectal adenocarcinoma.
  • In the current study, 59 surgically resected primary small intestinal adenocarcinomas (34 ampullary and 25 non-ampullary) were immunohistochemically examined for AMACR expression and compared with 66 colorectal adenocarcinomas (including 24 secondary tumors involving the small intestine by direct extension or metastasis).
  • The results show that no AMACR immunoreactivity was detected in normal-appearing small and large intestinal mucosa.
  • While 41 of 66 (62%) colorectal adenocarcinomas exhibited a variable degree of cytoplasmic staining, only 1 of 25 (4%) non-ampullary and 2 of 34 (6%) ampullary small intestinal adenocarcinomas showed positive AMACR immunoreactivity (P < 0.0001).
  • Interestingly, AMACR appeared to be less frequently expressed in mucinous or poorly differentiated colorectal adenocarcinomas when compared with non-mucinous or better-differentiated counterparts, suggesting an association with microsatellite instability status.
  • These results extend our previous observations that small intestinal adenocarcinomas differ markedly from colorectal adenocarcinomas despite their morphologic similarity.
  • The different AMACR expression patterns may not only provide an additional diagnostic tool in the distinction between adenocarcinomas of the small and large intestinal origins but may also shed light on further understanding of intestinal tumorigenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Racemases and Epimerases / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15958853.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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26. Munday JS, Brennan MM, Jaber AM, Kiupel M: Ovine intestinal adenocarcinomas: histologic and phenotypic comparison with human colon cancer. Comp Med; 2006 Apr;56(2):136-41
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  • [Title] Ovine intestinal adenocarcinomas: histologic and phenotypic comparison with human colon cancer.
  • Approximately 7% of old, unthrifty sheep (Ovis aries) in New Zealand have intestinal adenocarcinomas.
  • To investigate whether these sheep might be used as a model of human colonic neoplasia, the biologic behavior and histologic appearance of ovine intestinal adenocarcinomas were compared with those reported for human colonic adenocarcinomas.
  • We collected 50 intestinal tracts with grossly visible intestinal neoplasia from slaughtered sheep.
  • Neoplasms were assessed using World Health Organization guidelines for assessment of human colonic adenocarcinomas.
  • All ovine adenocarcinomas developed in the small intestine.
  • In contrast, only 4% of human intestinal tumors develop at this location, whereas the majority develop in the colon.
  • A visible polyp is present within 89% of human colonic adenocarcinomas, whereas polyps were present in only 46% of the ovine neoplasms.
  • Intestinal wall infiltration by the neoplastic cells and rates of lymph node (84% in sheep; 61% in humans) and distant (52% in sheep; 17% in humans) metastases were comparable between ovine and human adenocarcinomas.
  • However, ovine adenocarcinomas developed more peritoneal and fewer hepatic metastases than human adenocarcinomas.
  • Histologic grading of ovine tumors revealed cell differentiation similar to that reported within human colonic adenocarcinomas.
  • In conclusion, ovine intestinal adenocarcinomas, like human colonic adenocarcinomas, typically arise spontaneously and consistently develop widespread metastases.
  • [MeSH-major] Adenocarcinoma / veterinary. Colonic Neoplasms / pathology. Intestinal Neoplasms / veterinary. Sheep Diseases / pathology

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  • (PMID = 16639981.001).
  • [ISSN] 1532-0820
  • [Journal-full-title] Comparative medicine
  • [ISO-abbreviation] Comp. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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27. Terado Y, Kurata A, Ishida T, Imamura T, Sakamoto A: Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma. Pathol Int; 2010 Oct;60(10):701-5
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  • [Title] Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma.
  • We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male.
  • Adenocarcinoma without stromal invasion was observed adjacent to the small intestinal mucosa.
  • Immunohistochemistry of the adenocarcinoma tissue revealed p53 overexpression and high Ki-67 labeling index as well as positive staining for CD10, cytokeratin 7, and cytokeratin 20.
  • Therefore, the diagnosis of small intestinal adenocarcinoma was made.
  • To our knowledge, this is the first case of small intestinal adenocarcinoma arising in retroperitoneal mature cystic teratoma.
  • A unique feature of this case is that malignant transformation in retroperitoneal mature teratoma arose even in the fully developed intestine.
  • [MeSH-major] Adenocarcinoma / pathology. Neoplasms, Multiple Primary / pathology. Retroperitoneal Neoplasms / pathology. Teratoma / pathology

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  • [Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
  • [ErratumIn] Pathol Int. 2010 Dec;60(12):798
  • (PMID = 20846270.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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28. Ono M, Shirao K, Takashima A, Morizane C, Okita N, Takahari D, Hirashima Y, Eguchi-Nakajima T, Kato K, Hamaguchi T, Yamada Y, Shimada Y: Combination chemotherapy with cisplatin and irinotecan in patients with adenocarcinoma of the small intestine. Gastric Cancer; 2008;11(4):201-5
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  • [Title] Combination chemotherapy with cisplatin and irinotecan in patients with adenocarcinoma of the small intestine.
  • BACKGROUND: Small-bowel adenocarcinoma (SBA) is a rare tumor that has a poor response to chemotherapy and a poor prognosis.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Cisplatin / administration & dosage. Intestinal Neoplasms / drug therapy

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29. Ruiz-Tovar J, Martínez-Molina E, Morales V, Sanjuanbenito A: [Primary small bowel adenocarcinoma]. Cir Esp; 2009 Jun;85(6):354-9
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  • [Title] [Primary small bowel adenocarcinoma].
  • [Transliterated title] Adenocarcinoma primario de intestino delgado.
  • INTRODUCTION: Primary small bowel adenocarcinoma is an uncommon tumour, with non-specific symptoms that cause a delay in the diagnosis and consequently a worse outcome for the patient.
  • MATERIAL AND METHOD: We performed a retrospective study of our experience with 17 patients diagnosed with primary small bowel adenocarcinoma, excluding all the cases suggesting secondary involvement of the small bowel from an adenocarcinoma in other locations.
  • Those with duodenal tumours underwent 4 pancreaticoduodenectomies, 3 gastroenterostomies and 1 diagnostic biopsy; 6 bowel resections with lymphadenectomy, 2 en-bloc resections and 1 by-pass were performed on those with jejuno-ileal tumours.
  • CONCLUSIONS: Curative treatment consists of small bowel resection.
  • [MeSH-major] Adenocarcinoma. Duodenal Neoplasms. Ileal Neoplasms. Jejunal Neoplasms

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  • (PMID = 19344893.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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30. Huang CC, Yang CY, Wu MH, Wang MY, Yeh CC, Lai IR, Chen CN, Lin MT: Gasless laparoscopy-assisted versus open resection of small bowel lesions. J Laparoendosc Adv Surg Tech A; 2010 Oct;20(8):699-703
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  • [Title] Gasless laparoscopy-assisted versus open resection of small bowel lesions.
  • BACKGROUND: We had developed an innovative method of minimally invasive surgery using gasless laparoscopy in resection of the small bowel lesion.
  • This study aimed at evaluating the feasibility and efficacy of this procedure by comparison with traditional open small bowel surgery.
  • METHODS: A wedge or segmental resection of the small bowel for removal of the lesion was performed in 25 patients at National Taiwan University Hospital from September 2006 to January 2009.
  • CONCLUSIONS: GLAS for resection of the small bowel may be a feasible and safe procedure for the small bowel lesions.
  • It has the advantages of better cosmetic outcome, less blood loss, and earlier recovery of bowel movement.
  • [MeSH-major] Adenocarcinoma / surgery. Duodenal Neoplasms / surgery. Gastrointestinal Stromal Tumors / surgery. Ileal Neoplasms / surgery. Jejunal Neoplasms / surgery. Laparoscopy / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma / secondary. Carcinoma / surgery. Digestive System Surgical Procedures / methods. Feasibility Studies. Female. Humans. Intestine, Small / surgery. Male. Middle Aged. Treatment Outcome. Young Adult

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  • (PMID = 20809818.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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31. Akatsu T, Murai S, Kamiya S, Kojima K, Mizuhashi Y, Hasegawa H, Kitagawa Y: Perineal hernia as a rare complication after laparoscopic abdominoperineal resection: report of a case. Surg Today; 2009;39(4):340-3
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  • Computed tomography (CT) showed small intestine protruding through the pelvic floor into the perineal area.
  • We speculate that because laparoscopic surgery is minimally invasive, fewer postoperative adhesions in the abdominal cavity can result in the small bowel sliding more readily into the perineal area.
  • [MeSH-minor] Adenocarcinoma / surgery. Aged, 80 and over. Female. Humans. Rectal Neoplasms / surgery. Tomography, X-Ray Computed

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32. Bernstein C, Bernstein H, Payne CM, Dvorak K, Garewal H: Field defects in progression to gastrointestinal tract cancers. Cancer Lett; 2008 Feb 18;260(1-2):1-10
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  • We indicate, however, the generality of field defects in gastrointestinal cancers, including cancers of the oropharynx, esophagus, stomach, bile duct, pancreas, small intestine and colon/rectum.

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  • (PMID = 18164807.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095060-01; United States / NCI NIH HHS / CA / R21CA111513-01A1; United States / NCI NIH HHS / CA / CA095060-06A1; United States / NCI NIH HHS / CA / 5 R01 CA119087; United States / NCI NIH HHS / CA / R21 CA111513-02; United States / NCI NIH HHS / CA / CA111513-01A1; United States / NCI NIH HHS / CA / R01 CA119087; United States / NCI NIH HHS / CA / R21 CA111513; United States / NCI NIH HHS / CA / CA095060-04; United States / NCI NIH HHS / CA / P50 CA095060-03; United States / NCI NIH HHS / CA / CA119087-03; United States / NCI NIH HHS / CA / P50 CA095060-06A1; United States / NCI NIH HHS / CA / CA095060-01; United States / NCI NIH HHS / CA / P50 CA095060; United States / NCI NIH HHS / CA / CA095060-03; United States / NCI NIH HHS / CA / R21 CA111513-01A1; None / None / / P50 CA095060-05; United States / NCI NIH HHS / CA / CA119087-01A1; United States / NCI NIH HHS / CA / P50 CA095060-04; United States / NCI NIH HHS / CA / P50 CA095060-02; United States / NCI NIH HHS / CA / CA095060-02; United States / NCI NIH HHS / CA / CA119087-02; United States / NCI NIH HHS / CA / R01 CA119087-03; United States / NCI NIH HHS / CA / 1 P50 CA95060; United States / NCI NIH HHS / CA / P50 CA095060-05; United States / NCI NIH HHS / CA / R01 CA119087-02; United States / NCI NIH HHS / CA / R01 CA119087-01A1; United States / NCI NIH HHS / CA / CA111513-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Bile Acids and Salts
  • [Number-of-references] 69
  • [Other-IDs] NLM/ NIHMS39621; NLM/ PMC2744582
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33. Posey JA 3rd, Saif MW, Carlisle R, Goetz A, Rizzo J, Stevenson S, Rudoltz MS, Kwiatek J, Simmons P, Rowinsky EK, Takimoto CH, Tolcher AW: Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas. Clin Cancer Res; 2005 Nov 1;11(21):7866-71
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  • Unconfirmed partial responses were observed in two patients, one with metastatic small bowel adenocarcinoma and the other with metastatic esophageal cancer.

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  • (PMID = 16278410.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR00032
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 30IQX730WE / Polyethylene Glycols; 581079-18-7 / pegamotecan; XT3Z54Z28A / Camptothecin
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34. Ausloos F, Scagnol I, Belaiche J: [Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report]. Rev Med Liege; 2009 Jul-Aug;64(7-8):394-7
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  • [Title] [Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report].
  • [Transliterated title] Adénocarcinome de l'intestin grêle compliquant une maladie coeliaque de l'adulte: à propos d'un cas.
  • This small bowel adenocarcinoma is rare and concerns less than 5% of the digestive neoplasias.
  • We are reporting the case of a 67-years-old woman whose coeliac disease has been complicated 5 years thereafter by a jejunal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Celiac Disease / complications. Incidental Findings. Jejunal Neoplasms / complications. Jejunal Neoplasms / diagnosis

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  • (PMID = 19777919.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
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35. Friedrich-Rust M, Ell C: Early-stage small-bowel adenocarcinoma: a review of local endoscopic therapy. Endoscopy; 2005 Aug;37(8):755-9
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  • [Title] Early-stage small-bowel adenocarcinoma: a review of local endoscopic therapy.
  • Early adenocarcinomas in the small intestine are a rare entity.
  • Most adenocarcinomas in the small intestine are diagnosed at a more advanced stage.
  • After surgical resection, only 3 - 10 % are found in stage T1 and 0 - 3 % in stage Tis (high-grade intraepithelial neoplasia), resulting in an overall 3 - 13 % rate of early-stage small-intestinal adenocarcinomas.
  • The diagnosis of early small-intestinal carcinoma by endoscopy is still very rare, although it will probably improve with the development of new endoscopic techniques.
  • [MeSH-major] Adenocarcinoma / surgery. Endoscopy, Gastrointestinal. Intestinal Neoplasms / surgery

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  • (PMID = 16032496.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 68
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36. Yamaga Y, Ohana M, Nakamura T, Kikuchi S, Matsumura K, Takita M, Iwamoto S, Morisawa T, Miyajima S, Kida H, Okano A, Okinaga S, Kusumi F, Takakuwa H, Honjou G: [A case of jejunal adenocarcinoma with serum DUPAN-2 elevation]. Nihon Shokakibyo Gakkai Zasshi; 2010 Nov;107(11):1806-13
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  • [Title] [A case of jejunal adenocarcinoma with serum DUPAN-2 elevation].
  • Ileus with ulcerated jejunal tumor was diagnosed and biopsy revealed adenocarcinoma.
  • Surgical resection was performed: both tumors were adenocarcinoma, but the ovarian tumor was considered to be metastatic clinically and histologically.
  • This case shows a possible relation between small bowel adenocarcinoma and DUPAN-2.
  • [MeSH-major] Adenocarcinoma / diagnosis. Antigens, Neoplasm / blood. Jejunal Neoplasms / diagnosis

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  • (PMID = 21071898.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DU-PAN-2 antigen, human
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37. Ogata Y, Yamaguchi K, Sasatomi T, Uchida S, Akagi Y, Shirouzu K: [Treatment and outcome in small bowel cancer]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1454-7
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  • [Title] [Treatment and outcome in small bowel cancer].
  • In adenocarcinoma of the small intestine, delays in diagnosis are frequent, and the majority of patients present with advanced- stage disease and either lymph node involvement or distant metastatic disease.
  • Recent retrospective and prospective studies have helped to clarify the optimal chemotherapy approach for advanced small bowel adenocarcinoma.
  • The 72nd Japanese Society for Cancer of the Colon and Rectum have conducted a retrospective review of Japanese patients with adenocarcinoma of the jejunum or ileum.
  • The data indicated that although not statistically significant, there was a trend in median overall survival favoring the chemotherapy for advanced jejunal or ileal adenocarcinoma (17 months vs. 8 months, p=0.114).
  • [MeSH-major] Adenocarcinoma / therapy. Intestinal Neoplasms / therapy. Intestine, Small

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  • (PMID = 20716869.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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38. Chan OT, Chen ZM, Chung F, Kawachi K, Phan DC, Himmelfarb E, Lin F, Perry A, Wang HL: Lack of HER2 overexpression and amplification in small intestinal adenocarcinoma. Am J Clin Pathol; 2010 Dec;134(6):880-5
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  • [Title] Lack of HER2 overexpression and amplification in small intestinal adenocarcinoma.
  • HER2 overexpression and amplification have been studied as a therapeutic and prognostic target in a number of human cancers, including esophageal, gastric, and colorectal adenocarcinomas.
  • However, HER2 status has not been well investigated in primary small intestinal adenocarcinoma, probably because of its rarity.
  • In this study, we conducted immunohistochemical analysis and fluorescence in situ hybridization (FISH) for HER2 on 49 primary nonampullar small intestinal adenocarcinomas.
  • These observations demonstrate that HER2 protein overexpression and gene amplification are infrequent events, if they occur at all, in small intestinal adenocarcinoma.
  • Thus, routine immunohistochemical and/or FISH testing for HER2 for potential targeted anti-HER2 therapy may not be beneficial for patients with primary small intestinal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Gene Amplification. Intestinal Neoplasms / metabolism. Intestine, Small / metabolism. Receptor, ErbB-2 / metabolism

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  • (PMID = 21088150.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
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39. Abdulkareem FB, Faduyile FA, Daramola AO, Rotimi O, Banjo AA, Elesha SO, Anunobi CC, Akinde OR, Abudu EK: Malignant gastrointestinal tumours in south western Nigeria: a histopathologic analysis of 713 cases. West Afr J Med; 2009 May;28(3):173-6
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  • BACKGROUND: Malignant tumours of the gastro-intestinal tract are not as rare as previous studies suggest.
  • OBJECTIVE: To document the pattern, age and sex distribution as well as histopathology characteristics of malignant tumours of the gastro-intestinal system in Lagos and Sagamu in Southwestern Nigeria.
  • The oesophagus, pancreas, small intestine and gall bladder represented 18 (2.5%), 16 (2.2%), 12 (1.7%), and eight (1.1%) respectively.
  • Over half of the colorectal adenocarcinomata were located in the ano-rectum with 93 (23%) occurring in those below 40 years of age.
  • [MeSH-major] Adenocarcinoma / pathology. Gastrointestinal Neoplasms / pathology. Lymphoma, Non-Hodgkin / pathology

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  • (PMID = 20306734.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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40. Lutz JC, El-Bouihi M, Vidal N, Fricain JC, Robert M, Deminière C, Zwetyenga N: Mandibular metastases from an ileum stromal tumor. Rev Stomatol Chir Maxillofac; 2008 Dec;109(6):399-402
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  • Jaw metastases from the gastrointestinal (GI) tract usually evolve from adenocarcinoma of the esophagus, colon, and rectum.
  • These tumors are thought to arise from Cajal cells in GI tract walls, essential for intestine motor function.
  • The small intestine harbors only 30% of GIST.
  • The patient was treated with imatinib but died 11 months after the diagnosis.
  • DISCUSSION: The prevalence of GIST is low but the true incidence may be higher because of under-diagnosis.
  • GIST should be included in the differential diagnosis of intramandibular tumor in patients with prior or current non-oral malignancy.

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  • (PMID = 19010506.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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41. Kodaira C, Osawa S, Mochizuki C, Sato Y, Nishino M, Yamada T, Takayanagi Y, Takagaki K, Sugimoto K, Kanaoka S, Furuta T, Ikuma M: A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy. World J Gastroenterol; 2009 Apr 14;15(14):1774-8
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  • [Title] A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy.
  • Small bowel adenocarcinoma (SBA) in patients with Crohn's disease (CD) is quite rare, difficult to diagnose without surgery, and has a poor prognosis.
  • PET/CT detected an accumulation spot in the small bowel.
  • An endoscopic forceps biopsy specimen showed poorly differentiated adenocarcinoma.
  • There were some longitudinal ulcer scars near the tumor, and the chronic inflammation in the small bowel appeared to be associated with the cancer development.
  • Since early diagnosis is extremely difficult in these cases, novel techniques, such as PET/CT and DBE, may be expected to help in making a preoperative diagnosis of the development of SBA in CD.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / etiology. Crohn Disease / complications. Endoscopy, Gastrointestinal / methods. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / etiology. Intestine, Small / pathology

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  • (PMID = 19360924.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2668786
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42. Popnikolov NK, Gatalica Z, Adegboyega PA, Norris BA, Pasricha PJ: Downregulation of TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L in Barrett's esophagus with dysplasia and adenocarcinoma. Appl Immunohistochem Mol Morphol; 2006 Jun;14(2):161-5
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  • [Title] Downregulation of TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L in Barrett's esophagus with dysplasia and adenocarcinoma.
  • The aim of this study was to compare TRAIL/Apo2L expression in normal gastroesophageal (GE) junction, Barrett's esophagus with and without dysplasia, and associated adenocarcinoma.
  • Immunohistochemical evaluation of TRAIL expression was performed on formalin-fixed paraffin-embedded sections from 29 GE junction/esophageal biopsies, 20 gastric biopsies, 6 esophagectomies, 2 small bowel resection specimens, and 5 colon biopsies.
  • TRAIL was expressed in the foveolar epithelium of the histologically normal GE junctional mucosa and stomach as well as in the normal intestinal epithelium, with maximal expression in the surface epithelium.
  • TRAIL was rarely and weakly (1+) expressed in Barrett's esophagus with dysplasia (3/18, 16.7%) and adenocarcinoma (1/10, 10.0%) (P<0.001).
  • Similarities in the topographic pattern of TRAIL expression in the normal GE junction, stomach, small intestine, and colon suggest a common function of TRAIL throughout the gastrointestinal tract.

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  • (PMID = 16785783.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TNF-Related Apoptosis-Inducing Ligand
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43. Mönkemüller K, Neumann H, Meyer F, Kuhn R, Malfertheiner P, Fry LC: A retrospective analysis of emergency double-balloon enteroscopy for small-bowel bleeding. Endoscopy; 2009 Aug;41(8):715-7
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  • [Title] A retrospective analysis of emergency double-balloon enteroscopy for small-bowel bleeding.
  • Although the role of emergency esophagogastroduodenoscopy (EGD) and colonoscopy for upper and lower gastrointestinal bleeding (GIB) is well defined, there are no data on the concept of emergency double-balloon enteroscopy (DBE) for small-bowel bleeding.
  • The following diagnoses were made: actively bleeding Dieulafoy lesions of the small bowel, n = 2; bleeding tumors, n = 4 (carcinoids n = 2, adenocarcinoma n = 1, lipoma n = 1); bleeding angiodysplasias and/or large arteriovenous malformation (AVM), n = 2; multiple ulcers, n = 1; and no diagnosis, n = 1.
  • It appears that emergency DBE is technically feasible, facilitates both diagnosis and therapy and enables management of patients with massive overt obscure GIB.
  • This study is a first step in establishing the concept of emergency DBE for patients with suspected small-bowel bleeding.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Feasibility Studies. Female. Humans. Intestine, Small / pathology. Male. Middle Aged. Retrospective Studies. Treatment Outcome


44. Janot MS, Kersting S, Chromik AM, Tannapfel A, Uhl W: [Amyloidosis of the small intestine following whipple operation is a rare cause of chronic ileus and has to be considered as differential diagnosis]. Zentralbl Chir; 2010 Aug;135(4):345-9
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  • [Title] [Amyloidosis of the small intestine following whipple operation is a rare cause of chronic ileus and has to be considered as differential diagnosis].
  • [Transliterated title] Die Amyloidose des Dünndarms als seltene Differenzialdiagnose eines chronischen Ileus nach Whipple-Operation.
  • In this paper we report that secondary amyloidosis of the small intestine can produce similar symptoms and has to be evaluated as a rare differential diagnosis in chronic ileus.
  • Instead severe adhesions of the small intestine were detected.
  • The entire small intestine was covered with a substance that had a similar aspect to sugar icing.
  • Thereby the motility of the small intestine was constricted.
  • An extensive adhaesiolysis and a decompression of the bowel was carried out.
  • Diffuse amyloid deposits were found on the small intestine.
  • One man died four months later, after transfer to a geriatric hospital, because of intestinal atony and a serious senile depression.
  • Surgeons have to keep in mind that amyloidosis is a possible differential diagnosis in addition to relapse of tumour growth and peritoneal carcinomatosis in these patients.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Amyloidosis / diagnosis. Cystadenoma, Mucinous / surgery. Ileus / diagnosis. Intestinal Diseases / diagnosis. Intestine, Small. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Postoperative Complications / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Chronic Disease. Diagnosis, Differential. Fatal Outcome. Female. Humans. Male. Tissue Adhesions / diagnosis. Tissue Adhesions / pathology. Tissue Adhesions / surgery

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  • [Copyright] Georg Thieme Verlag Stuttgart ˙ New York.
  • (PMID = 20464655.001).
  • [ISSN] 1438-9592
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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45. Dizon DS, Perez K, DiSilvestro P, Taneja C, Ilson D: Stage IV small bowel carcinoma mimicking advanced ovarian cancer. Am Surg; 2009 Sep;75(9):864-5
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  • [Title] Stage IV small bowel carcinoma mimicking advanced ovarian cancer.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adult. Combined Modality Therapy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 19774966.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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46. Fishman PN, Pond GR, Moore MJ, Oza A, Burkes RL, Siu LL, Feld R, Gallinger S, Greig P, Knox JJ: Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases. Am J Clin Oncol; 2006 Jun;29(3):225-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases.
  • BACKGROUND: Small bowel adenocarcinoma is a rare cancer that has generally been considered resistant to chemotherapy, although little has been published on the role of chemotherapy.
  • A retrospective analysis was conducted of patients with advanced small bowel adenocarcinoma to explore chemotherapy use, and gain knowledge for ongoing management and future clinical trials.
  • PATIENTS AND METHODS: All patients with advanced adenocarcinoma of the small bowel treated at Princess Margaret Hospital (PMH) between 1986 and 2004 were identified through the cancer registry.
  • CONCLUSION: Chemotherapy appears to have activity in adenocarcinoma of the small bowel.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestinal Neoplasms / pathology

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  • (PMID = 16755174.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Ko S, Chu KM, Luk JM, Wong BW, Yuen ST, Leung SY, Wong J: CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach. J Pathol; 2005 Apr;205(5):615-22
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  • [Title] CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach.
  • CDX2 and liver-intestine (LI)-cadherin are intestine-specific markers and both are physiologically expressed in the small intestine and colon.
  • Overexpression of CDX2 was significantly associated with CDH17 in gastric adenocarcinoma.
  • Furthermore, the expression of CDX2 and LI-cadherin proteins was strongly coupled in intestinal metaplasia.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Cadherins / metabolism. Homeodomain Proteins / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 15732140.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDH17 protein, human; 0 / CDX2 protein, human; 0 / Cadherins; 0 / Homeodomain Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger
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48. Kalogerinis PT, Poulos JE, Morfesis A, Daniels A, Georgakila S, Daignualt T, Georgakilas AG: Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective. BMC Gastroenterol; 2010;10:109
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  • BACKGROUND: There is very small occurrence of adenocarcinoma in the small bowel.
  • We present a case of primary duodenal adenocarcinoma and discuss the findings of the case diagnostic modalities, current knowledge on the molecular biology behind small bowel neoplasms and treatment options.
  • CASE: The patient had a history of iron deficiency anemia and occult bleeding with extensive workup consisting of upper endoscopy, colonoscopy, capsule endoscopy, upper gastrointestinal series with small bowel follow through and push enteroscopy.
  • Due to persistent abdominal pain and iron deficiency anemia the patient underwent push enteroscopy which revealed adenocarcinoma of the duodenum.
  • The patient underwent en-bloc duodenectomy which revealed T3N1M0 adenocarcinoma of the 4th portion of the duodenum.
  • CONCLUSIONS: Primary duodenal carcinoma, although rare should be considered in the differential diagnosis of occult gastrointestinal bleeding when evaluation of the lower and upper GI tract is unremarkable.
  • We discuss the current evaluation and management of this small bowel neoplasm.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Duodenal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Duodenoscopy. Female. Humans. Laparotomy. Ligaments. Tomography, X-Ray Computed

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  • (PMID = 20849628.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2949773
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49. Aurello P, Dente M, D'Angelo F, Nigri G, Cescon M, Ramacciato G: Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient. Am Surg; 2009 Feb;75(2):189-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient.
  • [MeSH-major] Adenocarcinoma / pathology. Crohn Disease / etiology. Ileal Neoplasms / pathology. Intestinal Obstruction / etiology


50. Kasashima S, Kawashima A, Zen Y: Invasive micropapillary carcinoma of the colon in ascitic fluid: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):803-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Invasive micropapillary carcinoma (IMPC) is defined as having characteristic pathologic features of small papillary cell clusters surrounded by lacunar spaces and is known as an aggressive variant in advanced stages due to the high incidence of lymph node metastasis.
  • IMPC has been well described in other organs, including the breast, urinary bladder and lung but has been rarely described in the large intestine.
  • Ascitic fluid cytology showed adenocarcinoma with papillary features, and a colectomy specimen showed IMPC.
  • The cytologic features of this case were characterized by small papillary clusters with a smooth surface showing peripherally located cytoplasm with a rare central lumen, as "inside-out" cell clusters; these findings suggested IMPC.
  • Differentiation from adenocarcinoma of other organs may be difficult, but immunohistochemical profiles suggested a colorectal origin; it was positive for CK20 and negative for CK7.

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  • (PMID = 21053544.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Kudo SE: New frontiers of endoscopy from the large intestine to the small intestine. Gastrointest Endosc; 2007 Sep;66(3 Suppl):S3-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New frontiers of endoscopy from the large intestine to the small intestine.
  • [MeSH-major] Colonoscopes. Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Intestinal Diseases / therapy. Intestine, Small
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / therapy. Capsule Endoscopy. Colitis, Ulcerative / diagnosis. Colitis, Ulcerative / pathology. Colitis, Ulcerative / therapy. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Colonic Neoplasms / therapy. Colonic Polyps / diagnosis. Colonic Polyps / pathology. Colonic Polyps / therapy. Equipment Design. Humans. Image Enhancement / instrumentation

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  • (PMID = 17709026.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Musa AA, Agboola AO, Banjo AA, Shonubi AM: Rectal carcinoma in a nine-year-old Nigerian male child: case report. East Afr Med J; 2007 Feb;84(2):93-6
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  • Exploratory laparotomy was done for the patient which revealed fixed rectosigmoid tumour with metastases to the liver, omentum and small intestine and ascites was also found.
  • [MeSH-major] Adenocarcinoma / diagnosis. Colorectal Neoplasms / diagnosis. Intestine, Small / pathology
  • [MeSH-minor] Abdominal Pain / diagnosis. Child. Colostomy. Digital Rectal Examination. Fatal Outcome. Humans. Ileal Neoplasms / secondary. Intestinal Obstruction / diagnosis. Jejunal Neoplasms / diagnosis. Jejunal Neoplasms / secondary. Liver Neoplasms / secondary. Male

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  • (PMID = 17598671.001).
  • [ISSN] 0012-835X
  • [Journal-full-title] East African medical journal
  • [ISO-abbreviation] East Afr Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Kenya
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53. Overman MJ, Pozadzides J, Kopetz S, Wen S, Abbruzzese JL, Wolff RA, Wang H: Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. Br J Cancer; 2010 Jan 5;102(1):144-50
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  • [Title] Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine.
  • BACKGROUND: Despite having a dramatically larger surface area than the large intestine, the small intestine is an infrequent site for the development of adenocarcinoma.
  • To better understand the molecular abnormalities in small bowel adenocarcinoma (SBA), we characterised a number of candidate oncogenic pathways and the immunophenotype of this rare cancer.
  • CONCLUSIONS: These results suggest that alterations in DNA MMR pathways are common in SBAs, similar to what is observed in large bowel adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / genetics. Duodenal Neoplasms / genetics. Gene Expression Profiling. Immunophenotyping. Neoplasm Proteins / biosynthesis. Oncogenes

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  • (PMID = 19935793.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ PMC2813754
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54. Simmen FA, Frank JA, Wu X, Xiao R, Hennings LJ, Prior RL: Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon. BMC Gastroenterol; 2009 Sep 16;9:67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon.
  • METHODS: We examined efficacy of BB in inhibition of azoxymethane (AOM)-induced colon ACF and intestine tumors in male and female Sprague-Dawley rats (outbred strain).
  • There was a tendency (0.1 > P > 0.05) for fewer adenocarcinomas (relative to total of adenomatous polyps plus adenocarcinomas) in colons of female than male tumor-bearing rats; in small intestine, this gender difference was significant (P < 0.05).
  • BB favored (P < 0.05) fewer adenocarcinomas and more adenomatous polyps (as a proportion of total tumor number) in female rat small intestine.
  • Data indicate the potential for slowing tumor progression (adenomatous polyp to adenocarcinoma) by BB.

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  • (PMID = 19758446.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CB / N02-CB-07008
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / C-Peptide; MO0N1J0SEN / Azoxymethane
  • [Other-IDs] NLM/ PMC2752457
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55. Sumrall A, Soni N: Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association? Int J Gastrointest Cancer; 2006;37(4):146-8
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  • [Title] Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association?
  • After surgical excision and radiotherapy of dermatofibrosarcoma protuberans, the patient developed small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Dermatofibrosarcoma / pathology. Intestinal Neoplasms / pathology. Neoplasms, Second Primary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Intestine, Small / diagnostic imaging. Intestine, Small / pathology. Male. Radiography. Tumor Suppressor Protein p53 / genetics

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  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Gao C, Wang AY: Significance of increased apoptosis and Bax expression in human small intestinal adenocarcinoma. J Histochem Cytochem; 2009 Dec;57(12):1139-48
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  • [Title] Significance of increased apoptosis and Bax expression in human small intestinal adenocarcinoma.
  • Human small intestine accounts for 75% of the gastrointestinal (GI) length but for only 1-5% of GI tumors.
  • For this purpose, 77 samples from patients were examined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and immunohistochemistry, including 40 cases from normal small intestine (jejunum), 7 cases from jejunum and ileum adenocarcinomas, and 30 cases from normal colon.
  • The results showed that a significantly higher level of enterocyte apoptosis was observed in normal small intestine compared with small intestinal adenocarcinomas and normal colon (median of apoptotic index, 15.2% vs 0.1% and 1.6%, p<0.01).
  • In conclusion, increased apoptosis and expression of Bax, not Bcl-2 or the Bax/Bcl-2 ratio, may play some role in the relatively lower incidence of human small intestinal carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Apoptosis. Gene Expression Regulation, Neoplastic. Intestinal Neoplasms / pathology. Intestine, Small / metabolism. Intestine, Small / pathology. bcl-2-Associated X Protein / metabolism

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  • (PMID = 19729672.001).
  • [ISSN] 1551-5044
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / bcl-2-Associated X Protein
  • [Other-IDs] NLM/ PMC2778087
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57. Yamada K, Ikehara Y, Nakanishi H, Kozawa E, Tatematsu M, Sugiura H: Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma. J Orthop Sci; 2007 Nov;12(6):606-10
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  • [Title] Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma.
  • [MeSH-major] Acetabulum. Adenocarcinoma / secondary. Bone Neoplasms / secondary. Jejunal Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed

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  • (PMID = 18040646.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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58. van der Weyden L, Arends MJ, Dovey OM, Harrison HL, Lefebvre G, Conte N, Gergely FV, Bradley A, Adams DJ: Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis. Oncogene; 2008 Jul 24;27(32):4503-8
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  • [Title] Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis.
  • In this study we set out to test the hypothesis that loss of Rassf1a can cooperate with inactivation of the adenomatous polyposis coli (Apc) gene to accelerate intestinal tumourigenesis using the Apc-Min (Apc(Min/+)) mouse model, as mutational or deletional inactivation of APC is a frequent early event in the genesis of intestinal cancer.
  • Further, loss of RASSF1A has also been reported to occur in premalignant adenomas of the bowel.
  • By interbreeding isoform specific Rassf1a knockout mice with Apc(+/Min) mice, we showed that loss of Rassf1a results in a significant increase in adenomas of the small intestine and accelerated intestinal tumourigenesis leading to the earlier death of adenocarcinoma-bearing mice and decreased overall survival.
  • Collectively these data demonstrate cooperation between inactivation of Rassf1a and Apc resulting in accelerated intestinal tumourigenesis, with adenomas showing increased nuclear accumulation of beta-catenin, supporting a mechanistic link via loss of the known interaction of Rassf1 with beta-TrCP that usually mediates degradation of beta-catenin.
  • [MeSH-major] Genes, APC. Intestinal Neoplasms / etiology. Tumor Suppressor Proteins / physiology

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  • (PMID = 18391979.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 079643; United Kingdom / Cancer Research UK / / A8449; United Kingdom / Cancer Research UK / / ; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Mki67 protein, mouse; 0 / RASSF1 protein, mouse; 0 / Tumor Suppressor Proteins; 0 / beta Catenin
  • [Other-IDs] NLM/ EMS52273; NLM/ PMC3706934
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59. McCoy AM, Hackett ES, Callan RJ, Powers BE: Alimentary-associated carcinomas in five Vietnamese potbellied pigs. J Am Vet Med Assoc; 2009 Dec 1;235(11):1336-41
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  • Radiography revealed distended loops of small intestine in 2 pigs.
  • Types of tumor included cholangiocellular carcinoma, transmural gastric carcinoma, small intestinal adenocarcinoma, metastatic hepatocellular carcinoma, and carcinoma.
  • The tumors involved the stomach, small intestine, spiral colon, liver, and gall bladder.

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  • (PMID = 19951106.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Choquet P, Calon A, Breton E, Beck F, Domon-Dell C, Freund JN, Constantinesco A: Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice. C R Biol; 2007 Nov;330(11):821-7
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  • In vivo imaging could greatly facilitate these trials, but the small size of the animals is a major limitation for the direct visualization of intestinal tissue.
  • Here we report a method of in vivo imaging of the mouse intestine based on X-ray micro-computed tomography using multiple contrast agents.
  • This method was validated in the model of non-cancerous polyp-like heteroplasia that spontaneously develops in the caecum area of Cdx2+/- mutant mice and in the model of colon adenocarcinoma induced by administration of the chemical carcinogen azoxymethane.
  • As a simple and non-invasive method, multiple-contrast X-ray micro-computed tomography is appropriate for pre-clinical studies of intestinal diseases in living mice.
  • [MeSH-minor] Animals. Equipment Design. Heterozygote. Homeodomain Proteins / genetics. Intestinal Diseases / radiography. Male. Mice. Mice, Knockout. Transcription Factors / deficiency. Transcription Factors / genetics

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  • (PMID = 17923376.001).
  • [ISSN] 1631-0691
  • [Journal-full-title] Comptes rendus biologies
  • [ISO-abbreviation] C. R. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Cdx2 protein, mouse; 0 / Homeodomain Proteins; 0 / Transcription Factors
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61. Verma D, Stroehlein JR: Adenocarcinoma of the small bowel: a 60-yr perspective derived from M. D. Anderson Cancer Center Tumor Registry. Am J Gastroenterol; 2006 Jul;101(7):1647-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the small bowel: a 60-yr perspective derived from M. D. Anderson Cancer Center Tumor Registry.
  • OBJECTIVES: To analyze subsite distribution of small bowel adenocarcinoma (SBA) over a 60-yr interval and to determine the impact of age, gender, and ethnicity on SBA cross-referenced for selected variables including anatomic distribution.
  • METHODS: Data from 1944 to 2003 were extracted from the M. D.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Intestinal Neoplasms / epidemiology. Intestinal Neoplasms / pathology. Intestine, Small

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  • (PMID = 16863573.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Triantafillidis JK, Nasioulas G, Kosmidis PA: Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res; 2009 Jul;29(7):2727-37
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  • [Title] Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.
  • Patients with long-standing ulcerative colitis and Crohn's disease have an increased risk of developing colorectal cancer and patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.
  • Colorectal cancer appearing on the ground of inflammatory bowel disease is the result of a process which is believed to begin from no dysplasia progressing to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma, although colorectal cancer can arise without proceeding through each of these steps.
  • [MeSH-major] Cell Transformation, Neoplastic. Colorectal Neoplasms / epidemiology. Inflammatory Bowel Diseases / epidemiology

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  • (PMID = 19596953.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Number-of-references] 94
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63. Wu TJ, Yeh CN, Chao TC, Jan YY, Chen MF: Prognostic factors of primary small bowel adenocarcinoma: univariate and multivariate analysis. World J Surg; 2006 Mar;30(3):391-8; discussion 399
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  • [Title] Prognostic factors of primary small bowel adenocarcinoma: univariate and multivariate analysis.
  • BACKGROUND: Adenocarcinoma of the small bowel is relatively less common than malignancies of the esophagus, stomach, and colorectum.
  • In small bowel adenocarcinoma, various prognostic factors influence the disease-free status and overall survival rates.
  • MATERIALS AND METHODS: Eighty patients who were diagnosed with small bowel adenocarcinoma and treated at our institute between 1983 and 2003 were retrospectively reviewed.
  • CONCLUSIONS: Poor prognosis of small bowel adenocarcinoma may be related to a delay in the diagnosis and treatment of the disease.
  • Curative resection is the aim of surgical treatment for small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small

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  • (PMID = 16479330.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Sawada T, Nishimura M, Hirose K: [Long-term survival in a case of large bowel cancer--efficacy of CPT-11-based chemotherapy]. Gan To Kagaku Ryoho; 2005 Jul;32(7):1059-61
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  • [Title] [Long-term survival in a case of large bowel cancer--efficacy of CPT-11-based chemotherapy].
  • A 77-year-old woman underwent an ileocecal resection and a partial resection of the small intestine for cecal cancer.
  • However, ileus caused by a recurrence in the small intestine was detected two years and four months postoperatively, so an ileal resection was performed.
  • The patient was initially treated by combination therapy with a small dose of CPT-11 and CDDP.
  • It thus may be an effective regimen for advanced and recurrent large bowel cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Colorectal Neoplasms / drug therapy

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  • (PMID = 16044974.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 039LU44I5M / Floxuridine; 50SG953SK6 / Mitomycin; 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; V1JK16Y2JP / doxifluridine; XT3Z54Z28A / Camptothecin
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65. Chaiyasate K, Jain AK, Cheung LY, Jacobs MJ, Mittal VK: Prognostic factors in primary adenocarcinoma of the small intestine: 13-year single institution experience. World J Surg Oncol; 2008;6:12
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  • [Title] Prognostic factors in primary adenocarcinoma of the small intestine: 13-year single institution experience.
  • BACKGROUND: Adenocarcinoma of the small bowel is a relatively rare malignancy as compared to the other malignancies of the gastrointestinal tract.
  • Nonspecific presentation and infrequent occurrence often leads to a delay in diagnosis and consequent poor prognosis.
  • METHODS: The medical records of a total of 27 patients treated for adenocarcinoma of the small bowel at Providence Hospital and Medical Centers from year 1990 through 2003 were reviewed retrospectively.
  • RESULTS: The patients included nine males and eighteen females with a median age at diagnosis of 62 years.
  • Only 48% of the patients had an accurate preoperative diagnosis while another 33% had a diagnosis suspicious of small bowel malignancy.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Intestinal Neoplasms / mortality. Intestinal Neoplasms / surgery. Intestine, Small / pathology

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  • (PMID = 18237404.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2253527
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66. Namikawa T, Hanazaki K: Clinical analysis of primary anaplastic carcinoma of the small intestine. World J Gastroenterol; 2009 Feb 7;15(5):526-30
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  • [Title] Clinical analysis of primary anaplastic carcinoma of the small intestine.
  • Primary anaplastic carcinoma is a rare variant of small intestinal cancer.
  • Most reports of primary anaplastic carcinoma of the small intestine are isolated case reports, therefore the clinicopathological features, therapeutic management, and surgical outcome of this tumor type remain unclear.
  • This review analyzes the available clinical characteristics of primary anaplastic carcinoma of the small intestine and investigates key differences from differentiated adenocarcinoma of the small intestine.
  • A Medline search was performed using the keywords 'small intestine' and 'anaplastic carcinoma' or 'undifferentiated carcinoma'.
  • The literature revealed a poor prognosis for patients who underwent surgical resection for anaplastic carcinoma of the small intestine, which gave a 3-year overall survival rate of 10.8% and a median survival time of 5.0 mo.
  • The literature suggests that anaplastic carcinoma is markedly more aggressive than differentiated adenocarcinoma of the small intestine.
  • Surgical resection with the aim of complete tumor removal provides the only beneficial therapeutic option for patients with anaplastic carcinoma of the small intestine, because chemotherapy and radiation therapy have no significant effect on the rate of survival.
  • However, despite complete tumor resection, most patients with anaplastic carcinoma of the small intestine are at great risk of disease recurrence.
  • This report also highlights the importance of a systematic diagnostic approach for anaplastic carcinoma of the small intestine.
  • [MeSH-major] Carcinoma / pathology. Intestinal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intestinal Mucosa / pathology. Intestine, Small / pathology. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis. Survivors

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  • (PMID = 19195053.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2653339
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67. Biance N, Peycru T, Savoie PH, Avaro JP, Tardat E, Bertrand S, Balandraud P: [Small intestinal metastasis from non-intestinal tumors 1. Which primary tumors?]. J Chir (Paris); 2006 Mar-Apr;143(2):129-32
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  • [Title] [Small intestinal metastasis from non-intestinal tumors 1. Which primary tumors?].
  • [Transliterated title] Les métastases de l'intestin grêle de tumeurs extra digestives 1. Quelles tumeurs primitives?
  • [MeSH-major] Intestinal Neoplasms / secondary. Intestine, Small / pathology
  • [MeSH-minor] Adenocarcinoma / secondary. Aged, 80 and over. Carcinoma, Squamous Cell / secondary. Fatal Outcome. Humans. Kidney Neoplasms / pathology. Lung Neoplasms / pathology. Male. Melanoma / secondary. Middle Aged

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  • [ErratumIn] J Chir (Paris). 2006 May-Jun;143(3):following 200
  • (PMID = 16788557.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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68. Farrell S, Gray SB, Best BG: Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature. Int Surg; 2005 Apr-Jun;90(2):85-7
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  • [Title] Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature.
  • Primary adenocarcinoma of the ileum is an uncommon gastrointestinal malignancy, the symptoms of which are often insidious in onset.
  • This case history highlights the previously unreported finding of ileal adenocarcinoma presenting with mucusuria, caused by local invasion of the bladder in a 44-year-old male.
  • A review of the literature is included to highlight the incidence, risk factors, clinical presentation, investigation, and current management of adenocarcinoma of the small bowel.
  • [MeSH-major] Adenocarcinoma / secondary. Ileal Neoplasms / pathology. Intestinal Fistula / diagnosis. Urinary Bladder Fistula / diagnosis. Urinary Bladder Neoplasms / secondary

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  • (PMID = 16119711.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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69. Crook DW, Knuesel PR, Froehlich JM, Eigenmann F, Unterweger M, Beer HJ, Kubik-Huch RA: Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel disease. Eur J Gastroenterol Hepatol; 2009 Jan;21(1):54-65
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  • [Title] Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel disease.
  • PURPOSE: The goal of this study was to compare magnetic resonance enterography (MRE) and video capsule endoscopy (VCE) in suspected small bowel disease.
  • MATERIALS AND METHODS: Nineteen patients with suspected small bowel disease participated in a prospective clinical comparison of MRE versus VCE.
  • RESULTS: Small bowel pathologies were found in 15 out of 19 patients: Crohn's disease (n= 5), lymphoma (n= 4), lymphangioma (n= 1), adenocarcinoma (n= 1), postradiation enteropathy (n= 1), NSAID-induced enteropathy (n =1), angiodysplasia (n= 1), and small bowel adhesions (n= 1).
  • MRE revealed 19 extraenteric findings in 11 patients as well as small bowel adhesions not detected on VCE (n= 1).
  • Thus, VCE and MRE appear to be complementary methods which, when used in conjunction, may better characterize suspected small bowel disease.
  • [MeSH-major] Capsule Endoscopy. Intestinal Diseases / diagnosis. Intestine, Small. Magnetic Resonance Imaging / methods

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  • (PMID = 19086147.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] England
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70. Rautou PE, Hammel P, Couvelard A, Rivet P, Aubert A, Lévy P, Ruszniewski P: [Suspected malignant cancer of the pancreas associated with pseudo-invasive duodenal hamartomas in a patient with Peutz-Jeghers syndrome]. Gastroenterol Clin Biol; 2007 May;31(5):547-51
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  • [Transliterated title] Suspicion de tumeur pancréatique maligne liée à des hamartomes duodénaux pseudo-invasifs au cours d'un syndrome de Peutz-Jeghers.
  • A 29-year-old man with a previously known Peutz-Jeghers syndrome (PJS) was admitted for epigastric pain, emesis and weight loss due to both intestinal intussusception causing bowel obstruction and obstructive pancreatitis.
  • Because duodenal and/or pancreatic cancer was suspected due to weight loss, the pancreatic and bile duct obstruction, and the increased risk of small intestine and pancreatic adenocarcinoma in patients with PSJ, a pancreatoduodenectomy was performed.
  • [MeSH-major] Duodenal Diseases / complications. Hamartoma / complications. Intestinal Polyps / complications. Pancreatic Neoplasms / complications. Peutz-Jeghers Syndrome / complications


71. Olschwang S, Bonaïti-Pellié C, Feingold J, Frébourg T, Grandjouan S, Lasset C, Laurent-Puig P, Lecuru F, Millat B, Sobol H, Thomas G, Eisinger F: [Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer), hereditary predisposition to colorectal and endometrial adenocarcinomas]. Pathol Biol (Paris); 2006 May;54(4):215-29
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  • [Title] [Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer), hereditary predisposition to colorectal and endometrial adenocarcinomas].
  • [Transliterated title] Identification et prise en charge du syndrome HNPCC (hereditary non polyposis colon cancer). Prédisposition héréditaire aux cancers du côlon, du rectum et de l'utérus.
  • Patients affected by the disease are at high risk for colorectal and endometrial carcinomas, but also for small intestine, urothelial, ovary, stomach and biliary tract carcinomas.
  • [MeSH-major] Adenocarcinoma / genetics. Colonic Neoplasms / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Endometrial Neoplasms / genetics. Rectal Neoplasms / genetics


72. Mohammad A, Makaju R: Retrospective histopathological analysis of various neoplasms of different parts of the gastrointestinal tract seen at the Kathmandu University Teaching Hospital (KUTH), Dhulikhel, Nepal. Kathmandu Univ Med J (KUMJ); 2006 Oct-Dec;4(4):474-8
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  • OBJECTIVE: To find out the spectrum of various histopathologic types of primary neoplasms of different parts of the gastrointestinal tract (oesophagus, stomach, small intestine, colorectum, anal canal) seen at the Kathmandu University Teaching Hospital (KUTH), Dhulikhel as there exists a worldwide wide variation in the distribution of various neoplasms of different parts of the gastrointestinal tract, which appears largely due to exogenous factors rather than due to inherent differences between populations.
  • Out of these, 3 (16.7%) were of the oesophagus (all squamous cell carcinoma), 10 (55.5%) were of the stomach (six intestinal type and four diffuse type), 2 (11.1%) were of the small intestine (one was lymphoma of the mucosa associated lymphoid tissue--MALTOMA and other was a malignant gastrointestinal stromal tumour--GIST), 3 (16.7%) were of the colorectum (all adenocarcinoma), and none was of the anal canal.
  • CONCLUSION: Relatively large number of cases of the carcinoma of the stomach were found in our this small series of the cases of the gastrointestinal tract in comparison to the Western countries.

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  • (PMID = 18603957.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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73. Al-Brahim N, Ross C, Carter B, Chorneyko K: The value of postmortem examination in cases of metastasis of unknown origin-20-year retrospective data from a tertiary care center. Ann Diagn Pathol; 2005 Apr;9(2):77-80
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  • To evaluate the value of autopsy in determining the primary site of MUO, this study reviewed the Hamilton experience-over the last 20 years-with patients autopsied with clinical diagnosis of MUO.
  • METHODS: All autopsy diagnoses from cases performed at the Hamilton Health Sciences Center and St Joseph's Healthcare from 1980 to 2000 were reviewed.
  • Fifty-three cases of MUO were identified (MUO was defined as a patient with pathological and/or radiological diagnosis of a metastatic tumor for which the primary site of malignancy was unknown).
  • Pathological diagnoses at autopsy were adenocarcinoma (n = 37), small cell carcinoma (n = 6), anaplastic carcinoma (n = 3), and undifferentiated carcinoma (n = 3).
  • Primary tumors were identified in 27 patients (51%), most commonly in the lung (n = 8), large bowel (n = 6), and pancreas (n = 4).
  • Histochemical and immunohistochemical stains were helpful in reaching the diagnosis of a primary tumor in 4 of 27 cases.
  • (1) in this series, autopsy was helpful in establishing the diagnosis of a primary tumor in 51% of the cases, reaffirming the value of postmortem examination in these instances;.
  • (2) adenocarcinoma was the most frequent tumor presenting as MUO;.
  • (3) the lung and the large bowel were the most frequent sites for primary tumors; and (4) careful gross and histological examinations remain the most important tools in identifying the primary site.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Histocytochemistry / methods. Hospitals, University. Humans. Immunohistochemistry / methods. Intestinal Neoplasms / pathology. Intestine, Large. Lung Neoplasms / pathology. Male. Middle Aged. Pancreatic Neoplasms / pathology. Retrospective Studies. Staining and Labeling. Survival Analysis

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  • (PMID = 15806513.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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74. Chong AK, Chin BW, Meredith CG: Clinically significant small-bowel pathology identified by double-balloon enteroscopy but missed by capsule endoscopy. Gastrointest Endosc; 2006 Sep;64(3):445-9
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  • [Title] Clinically significant small-bowel pathology identified by double-balloon enteroscopy but missed by capsule endoscopy.
  • BACKGROUND: Capsule endoscopy (CE) is increasingly being used to investigate the small bowel for various indications, including obscure GI bleeding (OGB).
  • Double-balloon enteroscopy (DBE) is a new endoscopic technique developed to potentially view the entire small intestine while allowing therapeutic options to be carried out when appropriate.
  • OBJECTIVE: We described 4 patients with small-bowel pathology missed on CE but detected by DBE.
  • INTERVENTIONS: DBE followed by surgical exploration and resection of small-bowel pathology.
  • Definitive treatment of small-bowel pathology by surgical resection.
  • RESULTS: CE did not identify the small-bowel pathology in all 4 patients.
  • The 3 patients with OGB had small-bowel masses found by DBE.
  • Two of these were GI stromal tumors and one was an adenocarcinoma.
  • LIMITATIONS: Retrospective study and small sample size.
  • If there is a high index of suspicion of small-bowel pathology despite a negative CE, DBE should be performed.
  • [MeSH-major] Endoscopy, Gastrointestinal / methods. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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  • (PMID = 16923502.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Gockel I, Hansen T, Junginger T: Image of the month. Gastric juvenile polyposis (GJP) in germline SMAD4 mutation accompanied by gastric cancer. Arch Surg; 2008 Mar;143(3):311-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / genetics. Polyps / genetics. Smad4 Protein / genetics. Stomach Neoplasms / genetics
  • [MeSH-minor] Adult. Anastomosis, Roux-en-Y. Endoscopy, Gastrointestinal. Esophagus / surgery. Female. Gastrectomy. Germ-Line Mutation. Humans. Intestine, Small / surgery. Lymph Node Excision

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  • (PMID = 18347281.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SMAD4 protein, human; 0 / Smad4 Protein
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76. Liszka Ł, Zielińska-Pajak E, Pajak J, Gołka D, Huszno J: Coexistence of gastrointestinal stromal tumors with other neoplasms. J Gastroenterol; 2007 Aug;42(8):641-9
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  • The most common accompanying neoplasms were colorectal (nine cases) and gastric (four cases) adenocarcinoma, as well as pancreatic adenocarcinoma (three cases).
  • There was a tendency toward more common localization of a GIST in the small intestine in patients with other neoplasms than in patients with a GIST alone (P < 0.09).
  • A greater proportion of patients with a GIST localized in the small intestine and/or characterized by a very low risk of aggressive behavior and accompanying other neoplasms, compared with a GIST alone, most likely reflects the fact that in the first group, GISTs tended to be an incidental finding during surgery.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Colorectal Neoplasms / pathology. Gastrointestinal Stromal Tumors / pathology. Neoplasms, Multiple Primary / pathology. Pancreatic Neoplasms / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy. Confidence Intervals. Diagnosis, Differential. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Retrospective Studies


77. Versaci A, Macrì A, Ieni A, Terranova M, Leonello G, Saladino E, Speciale G, Famulari C: [Gastrointestinal stromal tumour: our experience]. Chir Ital; 2009 Mar-Apr;61(2):161-9
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  • These tumours originate in Cajal interstitial cells and the majority are located in the stomach and small intestine.
  • Imaging difficulties impede an early diagnosis; sometimes these tumours represent an unexpected intraoperative finding or an emergency abdominal picture.
  • One patient, with two synchronous gastric neoplasms (GIST + adenocarcinoma) died after 16 months, while the other 5 patients with gastric GIST are still alive; two patients with ileal GIST, treated with chemotherapy, died after 15 and 18 months, respectively.

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  • (PMID = 19536989.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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78. Pilleul F, Penigaud M, Milot L, Saurin JC, Chayvialle JA, Valette PJ: Possible small-bowel neoplasms: contrast-enhanced and water-enhanced multidetector CT enteroclysis. Radiology; 2006 Dec;241(3):796-801
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  • [Title] Possible small-bowel neoplasms: contrast-enhanced and water-enhanced multidetector CT enteroclysis.
  • PURPOSE: To prospectively evaluate the sensitivity and specificity of contrast material-enhanced and water-enhanced multidetector computed tomographic (CT) enteroclysis in depicting small-bowel neoplasms in symptomatic patients, with endoscopic, tissue, and follow-up findings as reference standards.
  • Two hundred nineteen patients (108 male, 111 female; age range, 17-98 years; mean, 53.1 years) with clinical suspicion of small-bowel neoplasm underwent contrast- and water-enhanced multidetector CT enteroclysis after normal findings of upper and lower gastrointestinal endoscopy.
  • The prospective interpretations of CT enteroclysis results include evaluation of focal bowel wall thickening, small-bowel masses, small-bowel stenosis, mesenteric stranding, enlarged mesenteric lymph nodes, and visceral metastasis.
  • The overall sensitivity and specificity in identifying patients with small-bowel lesions were 84.7% and 96.9%, respectively.
  • Findings of pathologic examination confirmed small-bowel tumor in 50 patients with carcinoid tumor (n = 19), adenocarcinoma (n = 7), lymphoma (n = 5), jejunal adenoma (n = 9), stromal tumor (n = 5), ectopic pancreas (n = 2), angiomatous mass (n = 2), or metastasis (n = 1).
  • CONCLUSION: Contrast- and water-enhanced multidetector CT enteroclysis had an overall accuracy of 84.7% for depiction of small-bowel neoplasms.
  • [MeSH-major] Intestinal Neoplasms / radiography. Intestine, Small. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Endoscopy, Gastrointestinal. Female. Humans. Iopamidol / analogs & derivatives. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Reference Standards. Sensitivity and Specificity

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  • [Copyright] (c) RSNA, 2006.
  • (PMID = 17053201.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 17E17JBP8L / iomeprol; JR13W81H44 / Iopamidol
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79. Pérez-Cuadrado E, Más P, Hallal H, Shanabo J, Muñoz E, Ortega I, López Martín A, Torrella E, López Higueras A, Martín A, Carballo F: Double-balloon enteroscopy: a descriptive study of 50 explorations. Rev Esp Enferm Dig; 2006 Feb;98(2):73-81
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  • AIM: To evaluate the utility of double-balloon enteroscopy for small-bowel disease.
  • We performed biopsies in 31% of cases with diagnoses of adenocarcinoma, lymphangiectasia secondary to tumor in celiac disease, and Whipple's disease.
  • CONCLUSIONS: Double-balloon enteroscopy is a useful and effective technique in the diagnosis and treatment of small intestine diseases, thus complementing capsule endoscopy.
  • [MeSH-major] Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Intestinal Diseases / diagnosis. Intestine, Small / pathology

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  • [CommentIn] Rev Esp Enferm Dig. 2006 Feb;98(2):65-8, 69-72 [16566638.001]
  • (PMID = 16566639.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Capsules
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80. Varghese R, Weedon R: 'Metachronous' adenocarcinoma of the small intestine. Int J Clin Pract Suppl; 2005 Apr;(147):106-8
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  • [Title] 'Metachronous' adenocarcinoma of the small intestine.
  • Adenocarcinoma of the small intestine accounts for less than 1% of primary gastrointestinal malignancies (1).
  • Small intestine contains 75% of the length of the gastrointestinal tract with 90% of the surface mucosal area, and yet carcinoma is rare.
  • Symptoms of small bowel adenocarcinoma are vague and non-specific, and this region is relatively inaccessible which together contributes to their late diagnosis and poor prognosis.
  • The authors report a case of two primary adenocarcinomas of the small intestine in the same patient.
  • [MeSH-major] Adenocarcinoma / radiography. Jejunal Neoplasms / radiography. Neoplasms, Second Primary / radiography

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  • (PMID = 15875642.001).
  • [ISSN] 1368-504X
  • [Journal-full-title] International journal of clinical practice. Supplement
  • [ISO-abbreviation] Int J Clin Pract Suppl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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81. Speranza G, Doroshow JH, Kummar S: Adenocarcinoma of the small bowel: changes in the landscape? Curr Opin Oncol; 2010 Jul;22(4):387-93
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  • [Title] Adenocarcinoma of the small bowel: changes in the landscape?
  • PURPOSE OF REVIEW: Small bowel adenocarcinoma (SBA) is a rare cancer with a poor prognosis and little information to guide its management.
  • RECENT FINDINGS: Recent advances in less invasive imaging tools may permit earlier and increased diagnosis of SBA.
  • SUMMARY: The rarity of the disease and difficulty in diagnosis contribute to the lack of prospective trials evaluating therapies for SBA.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestine, Small / drug effects. Intestine, Small / surgery

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  • (PMID = 20485170.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 2S9ZZM9Q9V / Bevacizumab; B76N6SBZ8R / gemcitabine
  • [Number-of-references] 43
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82. Su MC, Yuan RH, Lin CY, Jeng YM: Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system. Mod Pathol; 2008 Nov;21(11):1379-86
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  • [Title] Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system.
  • Cadherin-17, also called liver-intestine cadherin, is a calcium-dependent transmembrane glycoprotein that mediates cell-cell adhesion in intestinal epithelium.
  • Expression of cadherin-17 was reported in gastric, pancreatic, and colorectal adenocarcinomas but not in other tumors.
  • Whether cadherin-17 can be used as a marker for diagnosis of cancers is still unclear.
  • Among normal tissues, the expression of cadherin-17 was limited to epithelial cells of small intestine and colon.
  • Colorectal adenocarcinomas showed staining in 96% of cases and most of them had strong and diffuse staining.
  • Gastric, pancreatic, and biliary adenocarcinomas showed diffuse or scattered staining in about 25-50% of cases.
  • When a two-marker, Cadherin-17/cytokeratin 7, profile was used, 37 of 38 (97%) cadherin-17(+)/cytokeratin 7(-) tumors were colorectal adenocarcinomas; 49 of 56 (86%) cadherin-17(+)/cytokeratin 7(+) tumors were gastric, pancreatic, or biliary adenocarcinomas.
  • Our results show that cadherin-17 is a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Cadherins / analysis. Gastrointestinal Neoplasms / diagnosis
  • [MeSH-minor] Colorectal Neoplasms / chemistry. Colorectal Neoplasms / diagnosis. Female. Humans. Immunoenzyme Techniques. Male. Pancreatic Neoplasms / chemistry. Pancreatic Neoplasms / diagnosis. Stomach Neoplasms / chemistry. Stomach Neoplasms / diagnosis

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  • (PMID = 18552820.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDH17 protein, human; 0 / Cadherins
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83. Cardona DM, Zhang X, Liu C: Loss of carbamoyl phosphate synthetase I in small-intestinal adenocarcinoma. Am J Clin Pathol; 2009 Dec;132(6):877-82
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  • [Title] Loss of carbamoyl phosphate synthetase I in small-intestinal adenocarcinoma.
  • Carbamoyl phosphate synthetase I (CPS1), normally found in hepatocytes and small-intestine (SI) enterocytes, is the antigen of Hep Par 1 antibody.
  • Expression of CPS1 in invasive SI adenocarcinoma seems to be lost.
  • We retrospectively collected 36 total specimens, which included 31 SI adenomas and 21 adenocarcinomas.
  • Of the 21 invasive adenocarcinomas, 15 lost antigen expression (71%).
  • [MeSH-major] Adenocarcinoma / enzymology. Carbamoyl-Phosphate Synthase (Ammonia) / metabolism. Duodenal Neoplasms / enzymology. Duodenum / enzymology
  • [MeSH-minor] Adenoma / enzymology. Adenoma / pathology. Biomarkers, Tumor / metabolism. Duodenitis / enzymology. Duodenitis / pathology. Humans. Immunohistochemistry. Intestinal Mucosa / enzymology. Intestinal Mucosa / pathology. Neoplasm Invasiveness. Retrospective Studies

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  • (PMID = 19926579.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 6.3.4.16 / Carbamoyl-Phosphate Synthase (Ammonia)
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84. Shenderey RL, Thompson N, Mansfield JC, Rees C: Adenocarcinoma as a complication of small bowel Crohn's disease. Eur J Gastroenterol Hepatol; 2005 Nov;17(11):1255-7
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  • [Title] Adenocarcinoma as a complication of small bowel Crohn's disease.
  • Carcinoma is a recognized but rare complication of small bowel Crohn's disease.
  • This case series emphasizes the importance of considering this diagnosis in patients with small bowel Crohn's disease.
  • We report three cases in which patients were treated for presumed exacerbations of Crohn's, but were subsequently found to have underlying small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Crohn Disease / complications. Ileal Neoplasms / etiology. Jejunal Neoplasms / etiology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Intestinal Obstruction / etiology. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16215441.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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85. Chaïbi C, Cotte-Laffitte J, Sandré C, Esclatine A, Servin AL, Quéro AM, Géniteau-Legendre M: Rotavirus induces apoptosis in fully differentiated human intestinal Caco-2 cells. Virology; 2005 Feb 20;332(2):480-90
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  • [Title] Rotavirus induces apoptosis in fully differentiated human intestinal Caco-2 cells.
  • Rotaviruses, which are the main cause of viral gastroenteritis in young children, induce structural and functional damages in infected mature enterocytes of the small intestine.
  • To investigate a relationship between rotavirus infection and cell death by apoptosis, we used the human intestinal Caco-2 cell line.
  • [MeSH-minor] Adenocarcinoma. Annexin A5 / metabolism. Cell Differentiation. Cell Line, Tumor. Colonic Neoplasms. Cytochromes c / analysis. Flow Cytometry. Humans. In Situ Nick-End Labeling. Membrane Potentials / physiology. Mitochondria / physiology

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  • (PMID = 15680413.001).
  • [ISSN] 0042-6822
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Annexin A5; 9007-43-6 / Cytochromes c
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86. Xie J, Itzkowitz SH: Cancer in inflammatory bowel disease. World J Gastroenterol; 2008 Jan 21;14(3):378-89
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  • [Title] Cancer in inflammatory bowel disease.
  • Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC).
  • Colon cancer risk in inflammatory bowel disease increases with longer duration of colitis, greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of the bowel.
  • Patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.
  • Other extra intestinal cancers, such as hepatobiliary and hematopoietic cancer, have shown variable incidence rates.
  • [MeSH-major] Colorectal Neoplasms / physiopathology. Inflammatory Bowel Diseases / physiopathology. Neoplasms / physiopathology

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  • (PMID = 18200660.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 118
  • [Other-IDs] NLM/ PMC2679126
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87. Shimpo K, Beppu H, Chihara T, Kaneko T, Shinzato M, Sonoda S: Effects of aloe arborescens ingestion on azoxymethane-induced intestinal carcinogenesis and hematological and biochemical parameters of male F344 rats. Asian Pac J Cancer Prev; 2006 Oct-Dec;7(4):585-90
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  • [Title] Effects of aloe arborescens ingestion on azoxymethane-induced intestinal carcinogenesis and hematological and biochemical parameters of male F344 rats.
  • We examined the modifying effect of freeze-dried whole-leaf Aloe arborescens Miller var. natalensis Berger (Kidachi aloe in Japan; designated as 'ALOE') on azoxymethane (AOM)-induced intestinal carcinogenesis in rats.
  • The incidence of colorectal adenocarcinomas in the 0.2% (but not 1%) ALOE group showed a strong tendency for decrease (p = 0.056) from the control group.
  • Further, the adenocarcinoma incidence in the entire intestine (small and large intestines) in the 0.2% ALOE group was significantly (p = 0.024) decreased compared to the control value.
  • These results indicate that a low level of ALOE ingestion might have a mild suppressive effect on intestinal tumor growth without harmful side effects.
  • [MeSH-major] Adenocarcinoma / prevention & control. Aloe. Intestinal Neoplasms / prevention & control. Phytotherapy / methods

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  • (PMID = 17250432.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
  • [Chemical-registry-number] MO0N1J0SEN / Azoxymethane
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88. Shi Z, Dragin N, Miller ML, Stringer KF, Johansson E, Chen J, Uno S, Gonzalez FJ, Rubio CA, Nebert DW: Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype. Int J Cancer; 2010 Nov 15;127(10):2334-50
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  • Tissues from 16 different organs-including proximal small intestine (PSI), liver and preputial gland duct (PGD)-were evaluated; microarray cDNA expression and >30 mRNA levels were measured.
  • Cyp1a1(-/-) mice revealed markedly increased CYP1B1 mRNA levels in the PSI, and between 8 and 12 weeks developed unique PSI adenomas and adenocarcinomas.
  • PSI adenocarcinomas exhibited striking upregulation of the Xist gene, suggesting epigenetic silencing of specific genes on the Y-chromosome; the Rab30 oncogene was upregulated; the Nr0b2 tumor suppressor gene was downregulated; paradoxical overexpression of numerous immunoglobulin kappa- and heavy-chain variable genes was found-although the adenocarcinoma showed no immunohistochemical evidence of being lymphatic in origin.

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  • (PMID = 20127859.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES006096-149007; United States / NIEHS NIH HHS / ES / P30 ES006096-139007; United States / NIEHS NIH HHS / ES / ES006096-119007; United States / NIEHS NIH HHS / ES / ES014403-03; United States / NIEHS NIH HHS / ES / R01 ES014403-02; United States / NIEHS NIH HHS / ES / ES006096-159007; United States / NIEHS NIH HHS / ES / ES014403-02; United States / NIEHS NIH HHS / ES / ES006096-149007; United States / NIEHS NIH HHS / ES / R01 ES014403; United States / NIEHS NIH HHS / ES / R01 ES014403-04; United States / NIEHS NIH HHS / ES / P30 ES006096; United States / NIEHS NIH HHS / ES / R01 ES014403-03S1; United States / NIEHS NIH HHS / ES / ES014403-03S1; United States / NIEHS NIH HHS / ES / P30 ES006096-159007; United States / NIEHS NIH HHS / ES / ES006096-139007; United States / NIEHS NIH HHS / ES / ES006096-129007; United States / NIEHS NIH HHS / ES / R01 ES014403-03; United States / NIEHS NIH HHS / ES / P30 ES006096-119007; United States / NIEHS NIH HHS / ES / P30 ES006096-129007; United States / NIEHS NIH HHS / ES / P30 ES06096
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 3417WMA06D / Benzo(a)pyrene; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / Cyp1b1 protein, mouse; EC 1.14.14.1 / Cytochrome P-450 CYP1A1; EC 1.14.14.1 / Cytochrome P-450 CYP1B1
  • [Other-IDs] NLM/ NIHMS184552; NLM/ PMC2917638
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89. Zhang MQ, Chen ZM, Wang HL: Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma. Mod Pathol; 2006 Apr;19(4):573-80
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  • [Title] Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma.
  • Small intestinal adenocarcinoma is an uncommon neoplasm morphologically similar to or indistinguishable from colorectal adenocarcinoma.
  • Although much has been learned about genetic pathways critical to colorectal tumorigenesis, little is known about molecular alterations involved in the development of small intestinal adenocarcinoma.
  • In this study, we immunohistochemically compared non-ampullary small intestinal adenocarcinomas with sporadic colorectal adenocarcinomas for the expression of several proteins known to serve pivotal roles in colorectal tumorigenesis.
  • The results show that complete loss of adenomatous polyposis coli immunoreactivity, presumably resulting from its gene mutations, was observed in eight of 26 (31%) small intestinal adenocarcinomas and 36 of 51 (71%) colorectal adenocarcinomas (P = 0.0008).
  • Nuclear localization of beta-catenin, an indirect evidence of deregulated Wnt signaling pathway, was observed in 5 (19%) small intestinal adenocarcinomas and 36 (71%) colorectal adenocarcinomas (P<0.0001).
  • Total lack of nuclear staining for one or more of the DNA mismatch repair enzymes occurred in a similar low frequency in both small intestinal and colorectal adenocarcinomas, seen in two of 25 (8%) and 10 of 47 (21%) cases, respectively (P = 0.1958).
  • The frequencies of aberrant p53 and RB expression were also similar between small intestinal and colorectal adenocarcinomas.
  • These observations indicate that defects in the Wnt and microsatellite instability pathways occur in over 90% of colorectal adenocarcinomas, but in only 40% of small intestinal adenocarcinomas.
  • Small intestinal tumorigenesis appears to follow a distinct, yet unidentified, molecular pathway(s) from its colorectal counterpart despite their morphologic similarity.
  • [MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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  • (PMID = 16501564.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Retinoblastoma Protein; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
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90. Gay G, Delvaux M: Double balloon enteroscopy in Crohn's disease and related disorders: our experience. Gastrointest Endosc; 2007 Sep;66(3 Suppl):S82-90
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  • [MeSH-major] Crohn Disease / diagnosis. Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Intestinal Diseases / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Adult. Aged. Algorithms. Anti-Inflammatory Agents, Non-Steroidal / adverse effects. Biopsy. Capsule Endoscopy. Diagnosis, Differential. Equipment Design. Humans. Ileitis / chemically induced. Ileitis / diagnosis. Ileitis / therapy. Intestinal Mucosa / pathology. Jejunal Neoplasms / diagnosis. Jejunal Neoplasms / therapy. Linitis Plastica / diagnosis. Linitis Plastica / therapy. Male. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / therapy. Stomach Neoplasms / diagnosis. Stomach Neoplasms / therapy

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  • (PMID = 17709041.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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91. Lo YL, Ho CT, Tsai FL: Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin. Eur J Pharm Sci; 2008 Sep 2;35(1-2):52-67
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  • We evaluated the effects and mechanisms of glycocholic acid (GC), a bile acid, on inhibiting pump and non-pump resistance, and increasing the chemosensitivity of epirubicin in human colon adenocarcinoma Caco-2 cells and rat intestine.
  • GC increased the cytotoxicity of epirubicin, significantly increased the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis.
  • GC and epirubicin significantly reduced mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulated the MDR1 promoter region; suppressed the mRNA expression of Bcl-2; induced the mRNA expression of Bax; and significantly increased the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3.

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  • (PMID = 18606222.001).
  • [ISSN] 0928-0987
  • [Journal-full-title] European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • [ISO-abbreviation] Eur J Pharm Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Chromatin; 0 / DNA, Neoplasm; 0 / P-Glycoproteins; 3Z8479ZZ5X / Epirubicin; EC 1.13.12.- / Luciferases; G59NX3I3RT / Glycocholic Acid
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92. Overman MJ: Recent advances in the management of adenocarcinoma of the small intestine. Gastrointest Cancer Res; 2009 May;3(3):90-6
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  • [Title] Recent advances in the management of adenocarcinoma of the small intestine.
  • Adenocarcinoma of the small intestine is a rare malignancy with limited data available to guide therapeutic decisions.
  • Delays in diagnosis are frequent and the majority of patients will present with advanced-stage disease and either lymph node involvement or distant metastatic disease.
  • Recent retrospective and prospective studies have helped to clarify the optimal chemotherapy approach for advanced small bowel adenocarcinoma.
  • This article reviews the clinical features and evaluation of patients with small bowel adenocarcinoma and focuses on recent advances in management.

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  • (PMID = 19626152.001).
  • [ISSN] 1934-7820
  • [Journal-full-title] Gastrointestinal cancer research : GCR
  • [ISO-abbreviation] Gastrointest Cancer Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2713134
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93. Garrido A, Luque A, Vázquez A, Hernández JM, Alcántara F, Márquez JL: [Primary small bowel neoplasms as a complication of celiac disease]. Gastroenterol Hepatol; 2009 Nov;32(9):618-21
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  • [Title] [Primary small bowel neoplasms as a complication of celiac disease].
  • [Transliterated title] Neoplasias primarias de intestino delgado como complicación de la enfermedad celíaca.
  • The most serious complication in these patients is the development of neoplasms, the most frequent being enteropathy-associated T-cell lymphoma; however, an increase in the incidence of small bowel adenocarcinoma has also been described.
  • We present two cases of small bowel carcinoma in patients with celiac disease, which were diagnosed at the onset of the disease.
  • [MeSH-major] Adenocarcinoma / etiology. Celiac Disease / complications. Duodenal Neoplasms / etiology. Ileal Neoplasms / etiology

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  • (PMID = 19625106.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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94. Kim TH, Kim DY, Cho KH, Kim YH, Jung KH, Ahn JB, Chang HJ, Kim JY, Choi HS, Lim SB, Sohn DK, Jeong SY: Comparative analysis of the effects of belly board and bladder distension in postoperative radiotherapy of rectal cancer patients. Strahlenther Onkol; 2005 Sep;181(9):601-5
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  • PURPOSE: To compare the effect of reducing the irradiated small-bowel volume with the use of belly board, bladder distension or both methods combined, in patients with rectal cancer undergoing postoperative pelvic radiotherapy.
  • The irradiated small-bowel volume was calculated at 10% intervals from 10% to 100% of the prescribed dose.
  • RESULTS: The volume of the irradiated small bowel decreased in the order of group I, group II, group III, and group IV at all dose levels (p < 0.001).
  • In comparison to group I, the mean absolute volume reductions (relative volume reduction) of the irradiated small bowel were 41.5 +/- 20.1 cm(3) (33.9 +/- 12.9%) in group II, 76.6 +/- 30.5 cm(3) (55.1 +/- 17.8%) in group III, and 98.5 +/- 36.7 cm(3) (70.7 +/- 14.5%) in group IV.
  • CONCLUSION: Bladder distension was a more effective method than the belly board for reducing the irradiated small-bowel volume in postoperative pelvic radiotherapy of rectal cancer patients.
  • The combination of the belly board and bladder distension showed an additive effect and was the most effective method for reducing the irradiated small-bowel volume.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Intestine, Small / radiation effects. Radiotherapy Planning, Computer-Assisted. Rectal Neoplasms / radiotherapy. Urinary Bladder

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  • (PMID = 16170488.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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95. Kala Z, Válek V, Kysela P, Svoboda T: A shift in the diagnostics of the small intestine tumors. Eur J Radiol; 2007 May;62(2):160-5
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  • [Title] A shift in the diagnostics of the small intestine tumors.
  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • This work should answer the question, whether there is a method of making the diagnosis earlier when the disease is limited and easy to cure.
  • METHODOLOGY: A retrospective study comprising 96 patients having undergone surgery for a small intestine tumor in our hospital from 1996 to 2005 is presented.
  • In the year 1998 we changed our philosophy in trying to directly detect the small intestine pathology and not making the diagnosis by the exclusion only.
  • Intestinal ultrasound was performed on the Ultramark 3000 HDI device with autofocussable convex 5 MHz and linear 7.5 MHz probes or nowadays ATL 5000 HDI, 7-12 MHz linear probe.
  • RESULTS: We treated surgically 96 patients with the small intestine tumor.
  • A shift in the diagnostic algorithm was noticed in the bowel ultrasound now taking the lead.
  • CONCLUSION: The small bowel ultrasound can be recommended as the first choice method.
  • All patients with even very moderate abdominal symptoms ought to be examined for the small intestine pathology.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Abdomen, Acute / etiology. Abdomen, Acute / surgery. Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Aged. Algorithms. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Czech Republic. Endoscopy, Gastrointestinal. Endosonography. Female. Follow-Up Studies. Gastrointestinal Hemorrhage / etiology. Humans. Laparoscopy. Lymphoma / diagnosis. Lymphoma / surgery. Male. Melanoma / diagnosis. Melanoma / surgery. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17344005.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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96. Bilici A, Karadag B, Doventas A, Seker M: Gastric pneumatosis intestinalis associated with malignancy: an unusual case report. World J Gastroenterol; 2009 Feb 14;15(6):758-60
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  • The most common localization is the small intestine.
  • We report on a 94-year-old man with gastric PI associated with inoperable adenocarcinoma localized in the duodenum.
  • We suggest that in patients presenting with PI, malignancy should be considered in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Duodenal Neoplasms / diagnosis. Pneumatosis Cystoides Intestinalis / diagnosis. Pneumatosis Cystoides Intestinalis / radiography
  • [MeSH-minor] Aged, 80 and over. Blood Proteins / analysis. Blood Proteins / isolation & purification. Diagnosis, Differential. Fatal Outcome. Humans. Male. Stomach Diseases / diagnosis. Stomach Diseases / etiology. Stomach Diseases / radiography. Tomography, X-Ray Computed. Urine / cytology

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  • (PMID = 19222105.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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97. Fraquelli M, Sciola V, Villa C, Conte D: The role of ultrasonography in patients with celiac disease. World J Gastroenterol; 2006 Feb 21;12(7):1001-4
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  • The aim of the present review was to summarize the current evidence on the role of ultrasonography (US) and doppler-US in the diagnosis of celiac disease.
  • Firstly, case control studies identified some of these US signs and then in a prospective series some of these parameters, due to their high specificity, have been shown to be of value in confirming CD diagnosis, whereas others, due to their high sensitivity, have been demonstrated to be useful in excluding the presence of the disease.
  • The last part of this review will deal with the possible role of US in identifying the most severe and common intestinal complication of CD, i.e. the enteropathy-associated T cell non-Hodgkin lymphoma.
  • [MeSH-minor] Abdomen / blood supply. Abdomen / ultrasonography. Adenocarcinoma / diagnosis. Adenocarcinoma / ultrasonography. Algorithms. Case-Control Studies. Humans. Intestinal Neoplasms / ultrasonography. Intestine, Small / ultrasonography. Lymphoma, Non-Hodgkin / ultrasonography. Prospective Studies. Splanchnic Circulation. Ultrasonography. Ultrasonography, Doppler / methods

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  • (PMID = 16534837.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC4087888
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98. Stratopoulos C, Papakonstantinou A, Anagnostopoulos G, Terzis I, Tzimas G, Gourgiotis S, Vamvouka C, Hadjiyannakis E: Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study. Eur J Cancer Care (Engl); 2009 Sep;18(5):466-9
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  • [Title] Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study.
  • However, the coexistence of neurofibromatosis with small-bowel adenocarcinoma is exceedingly rare.
  • We present an uncommon case of neurofibromatosis type 1, involving the small bowel in a 73-year-old man, who was admitted to our department with signs of acute abdomen.
  • These nodules obstructed ileal lumen, while the intestine wall was perforated in one point.
  • Histology revealed neurofibromatosis type 1 with malignant transformation to small-bowel adenocarcinoma.
  • We suggest that adenocarcinoma of small bowel should be considered in the evaluation of acute abdominal pain in neurofibromatosis patients.
  • [MeSH-major] Adenocarcinoma / pathology. Ileal Neoplasms / pathology. Intestine, Small / pathology. Neoplasms, Multiple Primary / pathology. Neurofibromatosis 1 / pathology
  • [MeSH-minor] Abdomen, Acute / etiology. Aged. Follow-Up Studies. Humans. Intestinal Obstruction / etiology. Intestinal Obstruction / pathology. Male. Tomography, X-Ray Computed

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  • (PMID = 19473375.001).
  • [ISSN] 1365-2354
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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99. van Kouwen MC, Laverman P, van Krieken JH, Oyen WJ, Nagengast FM, Drenth JP: Noninvasive monitoring of colonic carcinogenesis: feasibility of [(18)F]FDG-PET in the azoxymethane model. Nucl Med Biol; 2006 Feb;33(2):245-8
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  • To address this issue, we studied the FDG uptake in AOM-induced rat colorectal adenocarcinoma (CRC) and correlated this with histopathological findings.
  • RESULTS: Macroscopic examination revealed 21 tumors (7 located in the small bowel and 14 in the colon) in 19 rats.
  • On histological examination, we found 10 colonic adenocarcinomas (the first being observed at Week 22) and 7 adenocarcinoma in the small bowel.
  • The [(18)F]FDG accumulation in small intestine carcinomas was well beyond background accumulation (P<.0001).
  • On PET scanning, two rats showed focal accumulation of the abdominal area, corresponding to small intestine carcinomas.
  • CONCLUSION: Adenocarcinomas had a significantly higher [(18)F]FDG uptake than background bowel uptake.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / radionuclide imaging. Colonic Neoplasms / metabolism. Colonic Neoplasms / radionuclide imaging. Disease Models, Animal. Fluorodeoxyglucose F18 / pharmacokinetics

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  • (PMID = 16546679.001).
  • [ISSN] 0969-8051
  • [Journal-full-title] Nuclear medicine and biology
  • [ISO-abbreviation] Nucl. Med. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; MO0N1J0SEN / Azoxymethane
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100. Kaukinen K, Peräaho M, Lindfors K, Partanen J, Woolley N, Pikkarainen P, Karvonen AL, Laasanen T, Sievänen H, Mäki M, Collin P: Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease. Aliment Pharmacol Ther; 2007 May 15;25(10):1237-45
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  • [Title] Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease.
  • Small intestinal biopsy and bone mineral density were investigated in 2001 and clinical features were followed up until 2005.
  • RESULTS: Thirteen coeliac patients had persistent small intestinal villous atrophy despite maintaining gluten-free diet.
  • In 2005, two of the non-responders had developed symptomatic refractory sprue, one died of lymphoma and one of carcinoid tumour, and one gastric adenocarcinoma was operated.
  • [MeSH-major] Celiac Disease / diet therapy. Intestine, Small / pathology. Lymphoma / etiology
  • [MeSH-minor] Adult. Aged. Atrophy. Female. Humans. Intestinal Mucosa / pathology. Middle Aged. Patient Care

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  • (PMID = 17451570.001).
  • [ISSN] 0269-2813
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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