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1. McCluggage WG, Jamison J, Boyde A, Ganesan R: Vulval intraepithelial neoplasia with mucinous differentiation: report of 2 cases of a hitherto undescribed phenomenon. Am J Surg Pathol; 2009 Jun;33(6):945-9
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  • [Title] Vulval intraepithelial neoplasia with mucinous differentiation: report of 2 cases of a hitherto undescribed phenomenon.
  • The mucinous cells were bland with eccentrically placed small regular nuclei and were positive with CAM5.2, carcinoembryonic antigen, epithelial membrane antigen, and cytokeratin 7, markers that are typically positive in the neoplastic cells of Paget disease.
  • As far as we are aware, mucinous differentiation has not been described in VIN, although mucinous metaplasia has rarely been reported in non-neoplastic vulval skin and in cutaneous squamous cell carcinoma in situ at extravulval sites.
  • The main differential diagnosis of the cases we describe is Paget disease or coexistent VIN and Paget disease and the immunophenotype of the mucinous cells may further highlight the potential for misdiagnosis.
  • Other possible differential diagnoses include Pagetoid squamous cell carcinoma in situ (Pagetoid VIN), basal cell carcinoma with sebaceous differentiation, and VIN involving skin appendage structures.
  • [MeSH-major] Carcinoma in Situ / pathology. Mucins / metabolism. Papillomavirus Infections / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Differentiation. Cervical Intraepithelial Neoplasia / pathology. Cyclin-Dependent Kinase Inhibitor p16 / biosynthesis. Diagnosis, Differential. Female. Human papillomavirus 16. Humans. Neoplasms, Second Primary / metabolism. Neoplasms, Second Primary / pathology. Paget Disease, Extramammary / metabolism. Paget Disease, Extramammary / pathology. Polymerase Chain Reaction

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  • (PMID = 19238078.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Mucins
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2. Bouraoui S, Khaddar RK, Mokni M, Badri T, Azaiez MY, Dhahri AB: [Extrapalpebral sebaceous carcinoma]. Ann Dermatol Venereol; 2006 Feb;133(2):165-7
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  • [Title] [Extrapalpebral sebaceous carcinoma].
  • [Transliterated title] Carcinome sébacé extra-palpébral.
  • Extra ocular sebaceous carcinoma is a rare carcinoma of the skin known to have difficulties of diagnosis because of its polymorphism of clinical and histopathological findings.
  • His prognosis depends of the precocity of the diagnosis.
  • It suspected a squamous cell carcinoma.
  • The histologic findings revealed a sebaceous carcinoma in his mixed and moderately differentiated type.
  • COMMENTS: Sebaceous carcinoma exhibits a variety of histologic growth patterns and diverse clinical presentations that the diagnosis is often difficult.
  • We discuss incidence as well as clinical, histological and established the diagnosis and the prognosis of this aggressive neoplasm.
  • [MeSH-major] Carcinoma. Facial Neoplasms. Sebaceous Gland Neoplasms

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  • (PMID = 16508603.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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3. Sramek B, Lisle A, Loy T: Immunohistochemistry in ocular carcinomas. J Cutan Pathol; 2008 Jul;35(7):641-6
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  • BACKGROUND: The distinction between ocular sebaceous carcinoma, poorly differentiated ocular squamous cell carcinoma and ocular basal cell carcinoma can be challenging.
  • RESULTS: Positive staining for cytokeratin (CK)7 was seen in 100% of sebaceous carcinomas, 77.8% of basal cell carcinomas and 67.7% of squamous cell carcinomas.
  • One hundred percent of sebaceous and basal cell carcinomas were positive for cytokeratin CAM 5.2, while only 83.3% of squamous cell carcinomas were positive.
  • Using epithelial membrane antigen (EMA), 100% of squamous cell carcinomas and 80% of sebaceous carcinomas were positive, while basal cell carcinomas were uniformly negative.
  • One hundred percent of basal cell carcinomas and 80% of sebaceous carcinomas were positive for Ber-EP4, while all squamous cell carcinomas were negative.
  • Finally, 77.8%, 20% and 16.7% of basal cell carcinomas, sebaceous carcinomas and squamous cell carcinomas showed immunoreactivity for the androgen receptor.
  • CONCLUSION: An EMA positive, Ber-EP4 positive immunophenotype supports sebaceous carcinoma, EMA positive, Ber-EP4 negative result supports squamous cell carcinoma and an EMA negative, Ber-EP4 positive result supports basal cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Eye Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology. Skin / pathology
  • [MeSH-minor] Biomarkers / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Keratin-7 / metabolism. Keratins / metabolism. Mucin-1 / metabolism. Receptors, Androgen / metabolism

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  • (PMID = 18201230.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / CAM 5.2 antigen; 0 / Keratin-7; 0 / Mucin-1; 0 / Receptors, Androgen; 0 / human epithelial antigen-125; 68238-35-7 / Keratins
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4. Lynch MC, Anderson BE: Ileocecal adenocarcinoma and ureteral transitional cell carcinoma with multiple sebaceous tumors and keratoacanthomas in a case of muir-torre syndrome. Dermatol Res Pract; 2010;2010
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  • [Title] Ileocecal adenocarcinoma and ureteral transitional cell carcinoma with multiple sebaceous tumors and keratoacanthomas in a case of muir-torre syndrome.
  • Cutaneous neoplasms including sebaceous tumors, keratoacanthomas, and basal cell carcinomas with sebaceous differentiation can be markers of internal malignancy associated with the Muir-Torre Syndrome (MTS).
  • We report a 56-year-old man with a diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) and ureteral transitional cell carcinoma who subsequently developed two sebaceous gland neoplasms and several keratoacanthomas, leading to the diagnosis of MTS.
  • The importance of continued clinical suspicion in the dermatological assessment of patients with sebaceous neoplasms is emphasized.

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  • (PMID = 20814549.001).
  • [ISSN] 1687-6113
  • [Journal-full-title] Dermatology research and practice
  • [ISO-abbreviation] Dermatol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2931389
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5. Sakuma T, Ueno C, Kawano K: [Sebaceous adenoma of caruncula lacrimalis: report of two cases]. Klin Monbl Augenheilkd; 2009 May;226(5):432-3
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  • [Title] [Sebaceous adenoma of caruncula lacrimalis: report of two cases].
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Adenocarcinoma, Sebaceous / therapy. Lacrimal Apparatus Diseases / pathology. Lacrimal Apparatus Diseases / therapy. Sebaceous Gland Neoplasms / pathology. Sebaceous Gland Neoplasms / therapy

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  • (PMID = 19507089.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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6. Waseem M, Humayun S, Ayaz B: Sebaceous carcinoma of upper eyelid. J Coll Physicians Surg Pak; 2010 Jul;20(7):487-9
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  • [Title] Sebaceous carcinoma of upper eyelid.
  • Histopathology report of the tissue revealed it to be the palpebral sebaceous carcinoma, while lymph node showed reactive hyperplasia.
  • [MeSH-major] Eyelid Neoplasms / surgery. Sebaceous Gland Neoplasms / surgery

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  • (PMID = 20642955.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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7. Becker K, Goldberg M, Helmbold P, Holbach LM, Loeffler KU, Ballhausen WG: Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas. Br J Dermatol; 2008 Dec;159(6):1282-9
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  • [Title] Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas.
  • BACKGROUND: Sebaceous gland carcinomas represent rare malignancies of the skin and some 60% of them demonstrate high-grade microsatellite instability on the background of a defective mismatch repair system.
  • However, a significant fraction of periocular sebaceous gland carcinomas exhibits microsatellite stability associated with a frequent loss of the candidate tumour suppressor fragile histidine triad (FHIT).
  • OBJECTIVES: We hypothesized that in those sebaceous gland carcinomas with microsatellite stability and loss of FHIT, effector molecules participating in homologous recombination repair (HRR), such as BRCA1/2, could be somatically inactivated.
  • METHODS: A pilot series of 10 paraffin-embedded sebaceous gland carcinoma specimens with a defined FHIT status was studied for loss of heterozygosity (LOH) events in the genes BRCA1, BRCA2, FHIT and WWOX.
  • RESULTS: Sebaceous gland carcinomas with FHIT negativity displayed LOH and biallelic deletions of the BRCA1 gene in five of 10 (50%) of the sebaceous gland carcinoma specimens analysed.
  • A homozygous p53 R248W gain-of-function mutation as the result of a CGG to TGG transition was identified in one of seven sebaceous gland carcinomas.
  • This particular sebaceous gland carcinoma presented with concomitant genomic deletions at the BRCA1 and BRCA2 loci, and also at the constitutively fragile sites FRA3B/FHIT and FRA16D/WWOX.
  • CONCLUSIONS: Our study demonstrates for the first time that microsatellite-stable FHIT-negative sebaceous gland carcinomas accumulate mutations that target central components of the HRR network.
  • This observation will prompt investigations in synthetic lethality of BRCA-deficient sebaceous gland carcinomas by therapeutic poly(ADP-ribose) polymerase inhibitors.
  • [MeSH-major] Acid Anhydride Hydrolases / genetics. Adenocarcinoma, Sebaceous / genetics. Genes, BRCA1. Genes, BRCA2. Neoplasm Proteins / genetics. Sebaceous Gland Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 18717684.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Protein p53; 0 / fragile histidine triad protein; EC 3.6.- / Acid Anhydride Hydrolases
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8. Takamura H, Yamashita H: Clinicopathological analysis of malignant eyelid tumor cases at Yamagata university hospital: statistical comparison of tumor incidence in Japan and in other countries. Jpn J Ophthalmol; 2005 Sep-Oct;49(5):349-54
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  • [Title] Clinicopathological analysis of malignant eyelid tumor cases at Yamagata university hospital: statistical comparison of tumor incidence in Japan and in other countries.
  • PURPOSE: To report the clinical and histopathological features of malignant eyelid tumor cases treated in our clinic.
  • We also compared the differences in the frequency of malignant eyelid tumor in various regions of Japan and worldwide.
  • METHODS: Retrospectively, we studied the records of the 38 cases of malignant eyelid tumor treated in Yamagata University Hospital over the last 17 years.
  • RESULTS: Data from our clinic: Among the total of 38 cases, 15 cases (39.5%) were diagnosed as basal cell carcinoma, 11 cases (28.9%) as sebaceous gland carcinoma, and 4 cases (10.5%) as squamous cell carcinoma.
  • In addition, three cases were malignant melanoma, two adenocarcinoma, one Merkel cell carcinoma, one malignant peripheral nerve sheath tumor, and one malignant lymphoma.
  • The prognosis of the cases with basal cell carcinoma and squamous cell carcinoma was good, and that of the other tumors was relatively poor.
  • During the same period, in Caucasians, basal cell carcinoma constituted about 80%-90% of the malignant eyelid tumors, whereas in Japan and Asian countries, basal cell carcinoma, sebaceous gland carcinoma, and squamous cell carcinoma each constituted about 20%-40%.
  • CONCLUSIONS: A racial difference in the incidence of basal cell carcinoma, sebaceous gland carcinoma, and squamous cell carcinoma can be considered in making a diagnosis.

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  • (PMID = 16187033.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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9. Kazakov DV, Kutzner H, Rütten A, Mukensnabl P, Michal M: Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma. Am J Dermatopathol; 2005 Jun;27(3):195-203
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  • [Title] Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma.
  • This report emphasizes a carcinoid-like pattern, a previously unrecognized feature in cutaneous sebaceous neoplasms.
  • We report 7 patients with sebaceous tumors in which neoplastic cells were arranged in a trabecular and ribbon-like pattern or formed rosettes/pseudorosettes.
  • The cases included 6 men and 1 woman, with their ages at the diagnosis ranging from 43 to 87 years (median age, 59).
  • Sebaceous differentiation in the form of mature sebocytes varied from almost none to approximately 10%.
  • Four lesions represented sebaceomas, and in 1 case microscopic delineation between a carcinoma and sebaceoma was difficult.
  • Electron microscopic examination performed in 1 case of carcinoma revealed lipid vacuoles in a minority of cells.
  • We conclude that the carcinoid-like pattern is another distinctive pattern indicative of sebaceous neoplasms.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biomarkers, Tumor / analysis. Carcinoid Tumor / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Diagnosis, Differential. Female. History, 16th Century. Humans. Immunohistochemistry. Inclusion Bodies / pathology. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / ultrastructure. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 15900121.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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10. Thosani MK, Marghoob A, Chen CS: Current progress of immunostains in Mohs micrographic surgery: a review. Dermatol Surg; 2008 Dec;34(12):1621-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In recent years, the application of immunostaining techniques has facilitated the successful removal of a number of common and less common cutaneous malignancies, including basal cell carcinoma, squamous cell carcinoma, malignant melanoma, dermatofibrosarcoma protuberans, microcystic adnexal carcinoma, sebaceous carcinoma, atypical fibroxanthoma, extramammary Paget's disease, and even sarcomas.

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  • (PMID = 19018832.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 127
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11. Stafanous SN: The switch flap in eyelid reconstruction. Orbit; 2007 Dec;26(4):255-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: Eight cases of large full-thickness eyelid defects resulting from excision of tumours such as basal cell carcinoma (bcc), squamous cell carcinoma (scc) and sebaceous gland carcinoma (sgc) were taken for repair using the switch flap technique.
  • RESULTS: Out of the eight cases of eyelid defects, one was from squamous cell carcinoma, three were from sebaceous gland carcinoma, and four were from infiltrative basal cell carcinoma.

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  • (PMID = 18097963.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Rizzardi C, Perin T, Schneider M, Rossi D, Brollo A, Melato M, Canzonieri V: Carcinoma of the uterine cervix with squamous and sebaceous differentiation. Int J Gynecol Pathol; 2009 May;28(3):292-5
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  • [Title] Carcinoma of the uterine cervix with squamous and sebaceous differentiation.
  • Sebaceous neoplasms, including carcinoma, can exceptionally arise in extracutaneous sites.
  • We present the third known case of carcinoma with sebaceous differentiation in the uterine cervix.
  • Histologic and immunohistochemical features suggested a metaplastic process within an otherwise usual squamous cell carcinoma.
  • We speculate that, by analogy with the skin where the epidermis and the 3 types of adnexa have a common embryologic origin from basal cell layer of the superficial ectoderm, it is possible that endocervical reserve cells, in addition to the well-known capacity of squamous differentiation, retain the potential to give rise to appendages including sebaceous glands.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Sebaceous Glands / pathology. Uterine Cervical Neoplasms / pathology

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  • (PMID = 19620949.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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13. Sa HS, Woo KI, Kim YD: Reverse modified Hughes procedure for uppereyelid reconstruction. Ophthal Plast Reconstr Surg; 2010 May-Jun;26(3):155-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The underlying diagnoses included sebaceous gland carcinoma (13), squamous cell carcinoma (3), and Merkel cell carcinoma (1).

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  • (PMID = 20489537.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Thomas CJ, Wood GC, Marks VJ: Mohs micrographic surgery in the treatment of rare aggressive cutaneous tumors: the Geisinger experience. Dermatol Surg; 2007 Mar;33(3):333-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Retrospective chart review of 26,000 cases treated with MMS at the Geisinger Medical Center Department of Dermatology during a 16-year period with the following diagnoses: poorly differentiated squamous cell carcinoma (PDSCC), dermatofibrosarcoma protuberans (DFSP), microcystic adnexal carcinoma (MAC), extramammary Paget's disease (EMPD), Merkel cell carcinoma (MCC), and sebaceous carcinoma (SEB CA).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Merkel Cell / surgery. Carcinoma, Squamous Cell / surgery. Child. Child, Preschool. Dermatofibrosarcoma / surgery. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Paget's Disease, Mammary / surgery. Retrospective Studies. Treatment Outcome

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  • (PMID = 17338692.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Cribier B: [Accurate diagnosis of adnexal tumours can be a matter of life or death]. Ann Dermatol Venereol; 2009 Feb;136(2):125-32
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  • [Title] [Accurate diagnosis of adnexal tumours can be a matter of life or death].
  • [MeSH-minor] Adenocarcinoma, Sebaceous / pathology. Diagnosis, Differential. Hamartoma Syndrome, Multiple / pathology. Humans. Male. Melanoma / pathology. Pilomatrixoma / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 19232249.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 58
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16. Alawi F, Siddiqui A: Sebaceous carcinoma of the oral mucosa: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Jan;99(1):79-84
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  • [Title] Sebaceous carcinoma of the oral mucosa: case report and review of the literature.
  • However, primary malignant sebaceous tumors of the oral mucosa are exceedingly rare.
  • To our knowledge, only 5 examples of intraoral sebaceous carcinoma have been reported in the literature.
  • This report describes a primary sebaceous carcinoma of the labial mucosa that arose in an area containing numerous Fordyce granules.
  • A brief review of the clinical and histopathologic features of sebaceous carcinoma is also presented.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Lip Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Choristoma / pathology. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Mouth Diseases / pathology. Mouth Mucosa / pathology. Mucin-1 / analysis. Receptors, Androgen / analysis. Sebaceous Glands / pathology. Sweat Glands / pathology

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  • (PMID = 15599352.001).
  • [ISSN] 1079-2104
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucin-1; 0 / Receptors, Androgen
  • [Number-of-references] 42
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17. Gomaa AH, Yaar M, Bhawan J: Cutaneous immunoreactivity of D2-40 antibody beyond the lymphatics. Am J Dermatopathol; 2007 Feb;29(1):18-21
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  • Podoplanin not only is highly expressed in lymphatic endothelium but also in other cell types, including sebaceous carcinoma cells.
  • Using the D2-40 antibody, our purpose was to evaluate expression of podoplanin in sebaceous glands of normal skin.
  • Strong immunostaining with D2-40 antibody was observed at the periphery of sebaceous glands and in skin lymphatic endothelium of all specimens, demonstrating that podoplanin is expressed in sebaceous glands of normal skin.
  • [MeSH-major] Antibodies, Monoclonal / metabolism. Endothelium, Lymphatic / metabolism. Membrane Glycoproteins / metabolism. Sebaceous Glands / metabolism. Skin / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Carcinoma / metabolism. Carcinoma / pathology. Female. Humans. Male. Middle Aged. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 17284957.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
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18. Pereira PR, Odashiro AN, Rodrigues-Reyes AA, Correa ZM, de Souza Filho JP, Burnier MN Jr: Histopathological review of sebaceous carcinoma of the eyelid. J Cutan Pathol; 2005 Aug;32(7):496-501
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  • [Title] Histopathological review of sebaceous carcinoma of the eyelid.
  • BACKGROUND: Sebaceous carcinoma of the eyelid can clinically mimic benign conditions, such as recurrent chalazion and inflammation and histopathologically squamous cell and basal cell carcinoma (BCC).
  • This retrospective study was undertaken as an attempt to improve the characterization and consequently the diagnosis of these tumors.
  • METHODS: Retrospective analysis was performed on eyelid specimens diagnosed as sebaceous carcinoma retrieved from Henry C.
  • Of these, 75% had features similar to squamous cell carcinoma (SqCC), some with dyskeratosis (30%) and 7% resembled BCC.
  • Superficial spread resembling Bowen-like disease was observed in 33% of the cases, pagetoid features in 33% and comedocarcinoma in 31.8%.
  • CONCLUSION: Sebaceous carcinoma presented as a poorly differentiated lesion in most cases of this series, which suggests a possibility of misdiagnosis because of its similarities to SqCC.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Chalazion / diagnosis. Diagnosis, Differential. Humans. Retrospective Studies. Single-Blind Method. Vacuoles / pathology

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  • (PMID = 16008694.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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19. Niemann C, Owens DM, Schettina P, Watt FM: Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type. Cancer Res; 2007 Apr 1;67(7):2916-21
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  • The NH(2) terminus of LEF1 is frequently mutated in human sebaceous tumors.
  • They developed sebaceous tumors, whereas controls developed squamous cell carcinomas.
  • [MeSH-major] Adenocarcinoma, Sebaceous / genetics. Cell Transformation, Neoplastic / genetics. Lymphoid Enhancer-Binding Factor 1 / genetics. Mutation. Sebaceous Gland Neoplasms / genetics. Skin Neoplasms / genetics


20. Gerdes MJ, Yuspa SH: The contribution of epidermal stem cells to skin cancer. Stem Cell Rev; 2005;1(3):225-31
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  • Tumors arising from the skin are of multiple phenotypes, with differing degrees of malignant potential.
  • In mouse models of skin carcinogenesis, tumors of squamous phenotype are the most common; however, human disease indicates that multiple phenotypes may arise from a common pool of stem cells that are then influenced by epigenetic factors.
  • The use of transgenic and knockout gene technologies with mice is unraveling some of the specific genes regulating fate determination in stem cells other than squamous lineage, including basal cell carcinoma and sebaceous adenomas.
  • [MeSH-major] Adenocarcinoma, Sebaceous / genetics. Carcinoma, Basal Cell / genetics. Epidermis. Epigenesis, Genetic. Neoplastic Stem Cells. Skin Neoplasms / genetics
  • [MeSH-minor] Animals. Disease Models, Animal. Gene Expression Regulation, Neoplastic / genetics. Humans. Mice. Mice, Knockout

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  • (PMID = 17142859.001).
  • [ISSN] 1550-8943
  • [Journal-full-title] Stem cell reviews
  • [ISO-abbreviation] Stem Cell Rev
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Number-of-references] 92
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21. Gáspár K, Veres I, Hunyadi J, Juhász I: Muir-Torre syndrome: a case of two brothers. Int J Dermatol; 2006 Sep;45(9):1124-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 16961537.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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22. Deprez M, Uffer S: Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol; 2009 May;31(3):256-62
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  • Eyelid tumors are the most common neoplasm in daily ophthalmology practice and encompass a wide variety of benign and malignant tumors.
  • Benign tumors largely predominated over malignant ones, representing 84% of cases in this series, and the 5 most frequent subtypes were squamous cell papilloma (26%), seborrheic keratosis (21%), melanocytic nevus (20%), hidrocystoma (8%), and xanthoma/xanthelasma (6%).
  • Basal cell carcinoma was the most frequent malignant tumor (86%), followed by squamous cell carcinoma (7%) and sebaceous carcinoma (3%).
  • For several tumor subtypes, there was a poor correlation between clinical and histological diagnosis, stressing the numerous pitfalls in the diagnosis of eyelid tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Child. Child, Preschool. Female. Hidrocystoma / pathology. Humans. Infant. Keratosis, Seborrheic / pathology. Male. Middle Aged. Nevus, Pigmented / pathology. Papilloma / pathology. Predictive Value of Tests. Retrospective Studies. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology. Xanthomatosis / pathology. Young Adult

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  • (PMID = 19384066.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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23. Sebastián Villalón-López J, Arturo Valle-Mejía C, Patiño-Lara A, Moreno-Pérez Bertha A, Alejo Muñoz-López J, Alcantar-Andrade A: Supraestructure maxillectomy and orbital exenteration for treatment of basal cell carcinoma of inferior eyelid: case report and review. J Cancer Res Ther; 2005 Jul-Sep;1(3):132-5
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  • [Title] Supraestructure maxillectomy and orbital exenteration for treatment of basal cell carcinoma of inferior eyelid: case report and review.
  • Basal cell carcinoma (BCC) is the most frequent type of skin cancer in humans, with cumulative exposure to ultraviolet radiation (UVR) as important risk factor for development of the illness as such as severe solar burns during childhood or adolescence.
  • Orbital exenteration is also used for treatment of malignancies of ocular tissues, mainly squamous cell carcinoma, sebaceous cell carcinoma and BCC.
  • The case of a 77 year-old patient is presented with BCC of inferior eyelid of 14 years duration, formerly managed with radiotherapy and, due to recurrent illness and invasion to the maxillary antrum; he needed supraestructure maxillectomy with left orbital exenteration.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Eyelid Neoplasms / surgery. Maxilla / surgery. Orbit Evisceration / methods
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / drug therapy. Humans. Male

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  • (PMID = 17998643.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 15
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24. Zhang S, Bao R, Bagby J, Abreo F: Fine needle aspiration of salivary glands: 5-year experience from a single academic center. Acta Cytol; 2009 Jul-Aug;53(4):375-82
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  • STUDY DESIGN: A total of 191 salivary gland FNAs were performed at Louisiana State University Health Science Center from 2003 to 2007, and all were done on major salivary glands except for 1 case.
  • There were 5 false negatives: 2 adenoid cystic carcinomas, 1 acinic cell carcinoma, 1 polymorphous low grade adenocarcinoma and 1 metastatic basaloid squamous cell carcinoma.
  • The only false positive was a pleomorphic adenoma misdiagnosed as adenoid cystic carcinoma.
  • Five benign neoplasms were interpreted as reactive processes, including 2 Warthin's tumors, 2 sebaceous lymphoadenomas and 1 pleomorphic adenoma.
  • The overall accuracy in distinguishing benign from malignant lesions was 79.1%, and the sensitivity for salivary neoplasia was 89.4%.
  • CONCLUSION: Our results are consistent with the literature that salivary gland FNA has good sensitivity, specificity and accuracy in the diagnosis of salivary neoplasms.
  • [MeSH-major] Biopsy, Fine-Needle. Salivary Gland Diseases / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • (PMID = 19697720.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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25. Lan MC, Lan MY, Lin CZ, Ho DM, Ho CY: Sebaceous carcinoma of the eyelid with neck metastasis. Otolaryngol Head Neck Surg; 2007 Apr;136(4):670-1
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  • [Title] Sebaceous carcinoma of the eyelid with neck metastasis.
  • [MeSH-major] Carcinoma / secondary. Eyelid Neoplasms / pathology. Head and Neck Neoplasms / secondary

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  • (PMID = 17418274.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Hernández JF, Santiago RS: [Sebaceous gland carcinoma of the eyelids]. Cir Cir; 2006 Nov-Dec;74(6):509-10
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  • [Title] [Sebaceous gland carcinoma of the eyelids].
  • [Transliterated title] Carcinoma de glándulas sebáceas de los párpados.
  • [MeSH-major] Eyelid Neoplasms / genetics. Neoplastic Syndromes, Hereditary / genetics. Sebaceous Gland Neoplasms / genetics

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  • [CommentOn] Cir Cir. 2004 Jan-Feb;72(1):47-53 [15087053.001]
  • (PMID = 17244511.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Comment; Letter
  • [Publication-country] Mexico
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27. Zirvi M, Seykora J, Ming ME: A rapidly growing nodule and dome-shaped yellow papules on the face. Arch Dermatol; 2005 Apr;141(4):515-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Acanthoma / pathology. Adenocarcinoma, Sebaceous / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 15837875.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Levy J, Cagnano E, Benharroch D, Monos T, Lifshitz T: Collision sebaceous and basal cell carcinomas of the eyelid. Ann Diagn Pathol; 2006 Jun;10(3):157-9
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  • [Title] Collision sebaceous and basal cell carcinomas of the eyelid.
  • OBJECTIVE: To report a rare case of collision sebaceous and basal cell carcinomas of the eyelid.
  • Histopathology showed mixed sebaceous as well as basal cell carcinoma with uninvolved surgical margins.
  • CONCLUSION: Sebaceous and basal cell carcinomas can coexist in the eyelid within the same clinical lesion.
  • Because of the potential risk of metastasis of sebaceous carcinoma, close follow-up of the patients is advisable.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16730311.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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29. Alzaraa A, Ghafoor I, Yates A, Dhebri A: Sebaceous carcinoma of the skin of the breast: a case report. J Med Case Rep; 2008;2:276
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  • [Title] Sebaceous carcinoma of the skin of the breast: a case report.
  • INTRODUCTION: Sebaceous gland tumours are rare and their presence should be considered as a marker for Muir-Torre Syndrome, alerting to search for an occult malignancy.
  • CASE PRESENTATION: A 43-year-old Caucasian female patient underwent excision of a sebaceous cyst.
  • Histopathology confirmed a sebaceous carcinoma.
  • CONCLUSION: Sebaceous carcinoma should be excised completely and followed-up for the detection of possible metastases.

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  • [Cites] World J Surg Oncol. 2006;4:8 [16466577.001]
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  • (PMID = 18706083.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2527503
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30. Ivan D, Prieto VG, Esmaeli B, Wistuba II, Tang X, Lazar AJ: Epidermal growth factor receptor (EGFR) expression in periocular and extraocular sebaceous carcinoma. J Cutan Pathol; 2010 Feb;37(2):231-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermal growth factor receptor (EGFR) expression in periocular and extraocular sebaceous carcinoma.
  • Sebaceous carcinoma has a predominant periocular origin but can also be extraocular.
  • There is no effective treatment for metastatic sebaceous carcinoma.
  • Extraocular carcinomas showed markedly increased levels of EGFR when compared to periocular carcinoma cases, both in terms of distribution (88% were > 25% of tumor cells vs. 16%) and intensity (77% were 2+ or 3+ vs. 21%) (p < 0.001).
  • Our results underscore the divergent mechanisms underlying the tumorigenesis of periocular and extraocular sebaceous carcinoma and suggest an association between aggressive behavior and increased EGFR expression in extraocular sebaceous carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Receptor, Epidermal Growth Factor / metabolism. Sebaceous Gland Neoplasms / metabolism

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  • (PMID = 19614729.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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31. Imakado S, Hamada K, Miura K: Low-grade sebaceous carcinoma presenting on the leg. Am J Dermatopathol; 2008 Dec;30(6):608-11
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  • [Title] Low-grade sebaceous carcinoma presenting on the leg.
  • The plaque was resected and diagnosed on microscopic examination as low-grade sebaceous carcinoma.
  • Sebaceous carcinoma on the leg seems extremely rare.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Leg. Sebaceous Gland Neoplasms / diagnosis

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  • (PMID = 19033940.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Mucin-1
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32. Burns SJ, Foss AJ, Butler TK: Outcome of periocular sebaceous gland carcinoma. Ophthal Plast Reconstr Surg; 2005 Sep;21(5):353-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome of periocular sebaceous gland carcinoma.
  • PURPOSE: To determine the long-term outcome of periocular sebaceous gland carcinoma and factors predictive of tumor recurrence.
  • METHODS: A retrospective case note review of all patients with periocular sebaceous gland carcinoma treated at the Queen's Medical Centre, Nottingham, United Kingdom, between 1992 and 1999.
  • CONCLUSIONS: In our unit, the best prognostic factor for sebaceous gland carcinoma is a histologic report confirming complete excision of the tumor, whatever the tumor size or pattern of spread identified.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 16234697.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Simeonov R, Simeonova G: Computer-assisted nuclear morphometry in relation to metastasis to regional lymph nodes in canine hepatoid adenocarcinomas. Anal Quant Cytol Histol; 2008 Dec;30(6):343-6
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  • [Title] Computer-assisted nuclear morphometry in relation to metastasis to regional lymph nodes in canine hepatoid adenocarcinomas.

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  • (PMID = 19160703.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Letter
  • [Publication-country] United States
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34. Maheshwari R: Review of orbital exenteration from an eye care centre in Western India. Orbit; 2010 Feb;29(1):35-8
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  • Except for one case all exenteration were for malignant neoplasm.
  • Histopathological classification of the neoplasm were sebaceous carcinoma (4 cases), basal cell carcinoma (3 cases), squamous cell carcinoma (3 cases), adenoid cystic carcinoma (1 case), transitional cell carcinoma (1 case), malignant fibrous histiocytoma (1 case), lymphoma (1 case) and mucormycosis (1 case).
  • CONCLUSION: Majority of exenterations performed were for neglected ocular or adnexal malignant lesions that could have been avoided provided patients reported earlier for treatment.

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  • (PMID = 20302408.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 20
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35. Honeycutt KA, Waikel RL, Koster MI, Wang XJ, Roop DR: The effect of c-myc on stem cell fate influences skin tumor phenotype. Mol Carcinog; 2010 Apr;49(4):315-9
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  • Nonmelanoma skin cancers (NMSCs) consist of a variety of tumor types including basal cell carcinoma, squamous cell carcinoma, a variety of hair follicle tumors, and sebaceous gland tumors.
  • These mice exhibited an increase in size and number of sebaceous glands, suggesting that c-myc diverted multipotential stem cells to a sebaceous lineage.
  • To this end, we exposed K14.MYC2 mice to a chemical carcinogenesis protocol and discovered that these mice were predisposed to develop sebaceous adenomas.
  • [MeSH-minor] 9,10-Dimethyl-1,2-benzanthracene / toxicity. Adenocarcinoma, Sebaceous / pathology. Animals. Carcinogens / toxicity. Cell Differentiation / genetics. Cell Lineage / genetics. Crosses, Genetic. Female. Heterozygote. Male. Mice. Mice, Inbred ICR. Mice, Inbred Strains. Mice, Transgenic. Multipotent Stem Cells / pathology. Papilloma / pathology. Phenotype. Sebaceous Gland Neoplasms / pathology. Tetradecanoylphorbol Acetate / pharmacology. Transgenes

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  • (PMID = 20146250.001).
  • [ISSN] 1098-2744
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR47898; United States / NCI NIH HHS / CA / CA09197; United States / NCI NIH HHS / CA / CA105491; United States / NCI NIH HHS / CA / CA52607; United States / NCI NIH HHS / CA / CA79998
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Proto-Oncogene Proteins c-myc; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; NI40JAQ945 / Tetradecanoylphorbol Acetate
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36. Izumi M, Tang X, Chiu CS, Nagai T, Matsubayashi J, Iwaya K, Umemura S, Tsuboi R, Mukai K: Ten cases of sebaceous carcinoma arising in nevus sebaceus. J Dermatol; 2008 Nov;35(11):704-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ten cases of sebaceous carcinoma arising in nevus sebaceus.
  • Although nevus sebaceus is known to develop various types of secondary neoplasms, it rarely causes carcinoma and only 14 cases of secondary sebaceous carcinoma have been reported.
  • In this study, 10 cases of sebaceous carcinoma arising in nevus sebaceus were collected.
  • Sebaceous carcinoma arising in nevus sebaceous predominantly occurred on the scalp (8/10) of elderly women (mean age, 67.7 years).
  • We found several pathological features of sebaceous carcinoma; that is, made up mainly of germinative cells, moderate nuclear atypia without pleomorphism and many mitoses (4-28/10 high-power field).
  • Adipophilin and perilipin antibodies highlighted lipid drops in the cytoplasm of the malignant cells in all cases.
  • In two cases there were coexisting benign-looking sebaceous lesions at the periphery of the main cancer nodule, and in these lesions p53 showed low positivity compared with the clearly malignant area.
  • All cases were treated by excision of the malignant lesion, with or without inclusion of the nevus sebaceus.
  • With these specific pathological and immunohistochemical findings using adipophilin, perilipin and p53, we have to consider the possibility that there is a tendency to underdiagnose secondary sebaceous carcinomas in nevus sebaceus.
  • These clinicopathological features of sebaceous carcinomas developing in the nevus sebaceus seem to indicate different biological entities from de novo sebaceous carcinoma.
  • [MeSH-major] Carcinoma / secondary. Nevus, Sebaceous of Jadassohn / pathology. Sebaceous Gland Neoplasms / secondary. Skin / pathology


37. Eisen DB, Michael DJ: Sebaceous lesions and their associated syndromes: part I. J Am Acad Dermatol; 2009 Oct;61(4):549-60; quiz 561-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous lesions and their associated syndromes: part I.
  • Sebaceous neoplasms have long been a source of confusion to dermatologists and pathologists alike.
  • Sebaceous lesions represent a broad spectrum of interesting entities that range from hamartomas, hyperplasias, and benign tumors to highly malignant neoplasms.
  • This article discusses the clinical and pathologic features of sebaceous hyperplasia, nevus sebaceous of Jadassohn, sebaceous adenoma, seboacanthoma, sebaceous epithelioma, sebaceoma, mantleoma, basal cell carcinoma with sebaceous differentiation, sebomatricoma (sebomatrixoma), and sebaceous carcinoma.
  • [MeSH-major] Sebaceous Gland Diseases / classification. Sebaceous Gland Diseases / pathology. Sebaceous Gland Neoplasms / classification. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 19751879.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 145
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38. Tanaka T, Sato H, Tada A, Moriya T, Wada Y, Nishida K: Case of orbital sebaceous carcinoma developing twenty-seven years after enucleation. Jpn J Ophthalmol; 2008 Jul-Aug;52(4):344-5
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  • [Title] Case of orbital sebaceous carcinoma developing twenty-seven years after enucleation.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eye Enucleation. Orbital Neoplasms / pathology. Postoperative Complications

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  • (PMID = 18773280.001).
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39. Rangel J, McCalmont TH: Intracytoplasmic adipophilin immunopositivity: a pitfall in the distinction of metastatic renal carcinoma from sebaceous carcinoma. J Cutan Pathol; 2010 Dec;37(12):1193-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracytoplasmic adipophilin immunopositivity: a pitfall in the distinction of metastatic renal carcinoma from sebaceous carcinoma.
  • [MeSH-major] Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Membrane Proteins / metabolism. Neoplasm Proteins / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 20950361.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / perilipin 2
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40. Kuznetsov SG, Haines DC, Martin BK, Sharan SK: Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice. Cancer Res; 2009 Feb 1;69(3):863-72
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  • Strikingly, Rad51c mutation in DH-cis mice promoted the development of tumors of specialized sebaceous glands and suppressed tumors characteristic of Trp53 mutation.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / genetics. Alleles. Animals. Embryonic Development / genetics. Embryonic Stem Cells / cytology. Embryonic Stem Cells / physiology. Female. Loss of Heterozygosity. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Sebaceous Gland Neoplasms / genetics. Sex Factors

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  • (PMID = 19155299.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 BC010387-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RAD51C protein, mouse; 0 / Tumor Suppressor Protein p53; EC 2.7.7.- / Rad51 Recombinase
  • [Other-IDs] NLM/ NIHMS81871; NLM/ PMC2754281
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41. Hong HH, Houle CD, Ton TV, Sills RC: K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse. Toxicol Pathol; 2007 Jan;35(1):81-5
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  • In 2-year mouse studies, ethylene oxide (EO) induced lung, Harderian gland (HG), and uterine neoplasms.
  • These data show a strong predilection for development of K-ras mutations in EO-induced lung, Harderian gland, and uterine neoplasms.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma / genetics. Carcinogens / toxicity. Ethylene Oxide / toxicity. Genes, ras. Lung Neoplasms / genetics. Sebaceous Gland Neoplasms / genetics. Uterine Neoplasms / genetics
  • [MeSH-minor] Animals. DNA, Neoplasm / analysis. Disinfectants / toxicity. Dose-Response Relationship, Drug. Female. Harderian Gland / drug effects. Harderian Gland / pathology. Inhalation Exposure. Male. Mice. Mice, Inbred Strains. Mutation

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  • (PMID = 17325976.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / DNA, Neoplasm; 0 / Disinfectants; JJH7GNN18P / Ethylene Oxide
  • [Other-IDs] NLM/ NIHMS33464; NLM/ PMC2099306
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42. Dim-Jamora KC, Perone JB: Management of cutaneous tumors with mohs micrographic surgery. Semin Plast Surg; 2008 Nov;22(4):247-56
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  • We discuss the use of Mohs micrographic surgery for the following cutaneous tumors: basal cell carcinoma, squamous cell carcinoma, melanoma in situ, dermatofibrosarcoma protuberans, Merkel cell carcinoma, microcystic adnexal carcinoma, atypical fibroxanthoma, and sebaceous carcinoma.

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  • (PMID = 20567701.001).
  • [ISSN] 1536-0067
  • [Journal-full-title] Seminars in plastic surgery
  • [ISO-abbreviation] Semin Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2884874
  • [Keywords] NOTNLM ; Mohs micrographic surgery / cutaneous oncology / skin cancer
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43. Teo EY, Wang YS: Fleshy facial lesion on an 80-year-old Dayak woman--quiz case. Arch Dermatol; 2009 Nov;145(11):1325-30
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  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Face. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 19917969.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Gallego-Pinazo R, España Gregori E, Aviñó Martínez J, Salom Alonso L, Tormo Micó A, Villanueva Martí R, Díaz-Llopis M: [Multidisciplinary management of an anaplastic sebaceous carcinoma of the eyelid in a 40-year-old woman]. Arch Soc Esp Oftalmol; 2010 Feb;85(2):76-8
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  • [Title] [Multidisciplinary management of an anaplastic sebaceous carcinoma of the eyelid in a 40-year-old woman].
  • [Transliterated title] Abordaje multidisciplinar de un carcinoma sebáceo anaplásico palpebral en una paciente de 40 años.
  • The extemporaneous biopsy was reported as sebaceous carcinoma.
  • DISCUSSION: The precocity in diagnosing sebaceous carcinomas of the eyelids is the main prognostic factor.
  • The reconstruction in cases with need of complete eyelid exeresis is feasible by means of a palate mucosa graft.
  • [MeSH-major] Adenocarcinoma, Sebaceous

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  • (PMID = 20566179.001).
  • [ISSN] 1989-7286
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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45. Donati M, Gandolfo L, Privitera A, Brancato G, Cardi F, Donati A: Superficial parotidectomy as first choice for parotid tumours. Chir Ital; 2007 Jan-Feb;59(1):91-7
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  • Malignant tumours account for 14-25% of cases.
  • Sixteen patients presented with a history of a painless parotid lump.
  • Diagnosis was achieved by ultrasound scan and MRI.
  • At histology, 10 pleomorphic adenomas, 4 Warthin's tumours, 1 lymphoepithelial cyst and 1 sebaceous adenocarcinoma were detected.
  • In the single case of carcinoma, the 6 peri-glandular lymph nodes included in the specimen were metastasis-free.
  • [MeSH-major] Parotid Neoplasms / surgery. Salivary Gland Fistula / surgery

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  • (PMID = 17361936.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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46. Xu XL, Li B, Sun XL, Li LQ, Ren RJ, Gao F: [Clinical and pathological analysis of 2639 cases of eyelid tumors]. Zhonghua Yan Ke Za Zhi; 2008 Jan;44(1):38-41
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  • The 5 leading eyelid malignant tumors were basal cell carcinoma, sebaceous gland carcinoma, lymphoma, squamous cell carcinoma and melanoma.
  • The mean age at diagnosis was 61 years for basal cell carcinoma and sebaceous gland carcinoma, 57 years and 52 years for squamous cell carcinoma and melanoma, respectively, and 48 years for lymphoma.
  • There was no significant sex predilection in basal cell carcinoma and sebaceous gland carcinoma.
  • Melanoma and lymphoma occurred more commonly in women, whereas squamous cell carcinoma occurred more commonly in men.
  • CONCLUSIONS: Basal cell carcinoma and sebaceous gland carcinoma were the most common malignant eyelid tumors, and lymphoma ranked third and had an increasing trend.
  • The malignant tumors occurred predominantly in the elderly of 60 years and above.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology. Lymphoma / pathology

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  • (PMID = 18510241.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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47. Arits A, van Marion AM, Thissen CA, Kloos R, Kelleners-Smeets NW: Development and progression of a periorbital sebaceous gland carcinoma in situ. Acta Derm Venereol; 2010 Sep;90(5):529-30
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  • [Title] Development and progression of a periorbital sebaceous gland carcinoma in situ.
  • [MeSH-major] Adenoma / diagnosis. Carcinoma in Situ / diagnosis. Eyelid Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Biopsy. Disease Progression. Humans. Male. Neoplasm Invasiveness. Time Factors. Treatment Outcome

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  • (PMID = 20814637.001).
  • [ISSN] 1651-2057
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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48. Leibovitch I, Selva D, Huilgol S, Davis G, Dodd T, James CL: Intraepithelial sebaceous carcinoma of the eyelid misdiagnosed as Bowen's disease. J Cutan Pathol; 2006 Apr;33(4):303-8
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  • [Title] Intraepithelial sebaceous carcinoma of the eyelid misdiagnosed as Bowen's disease.
  • BACKGROUND: Sebaceous carcinoma (SC) is well known for its ability to masquerade clinically and histologically as a variety of periocular conditions resulting in a delayed diagnosis.
  • We present a series of periocular SC cases and discuss the difficulties in histopathological diagnosis when this tumor presents with a Bowenoid pattern of intraepithelial spread.
  • Histopathologically, 87.5% of cases were misdiagnosed as Bowen's disease (BD) on the initial biopsy.
  • Six of these cases showed no invasive disease on the initial biopsy and were eventually found to be invasive SC on subsequent excisions.
  • Delay in diagnosis ranged from 0 to 56 months.
  • CONCLUSIONS: SC should always be considered in the histological differential diagnosis of any eyelid lesion which resembles BD, particularly if the upper eyelid is involved or if multivacuolated cytoplasmic clear cell changes are seen.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Bowen's Disease / diagnosis. Eyelid Neoplasms / diagnosis. Mohs Surgery. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16630181.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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49. Yoon JS, Kim SH, Lee CS, Lew H, Lee SY: Clinicopathological analysis of periocular sebaceous gland carcinoma. Ophthalmologica; 2007;221(5):331-9
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  • [Title] Clinicopathological analysis of periocular sebaceous gland carcinoma.
  • BACKGROUND: We analyzed the clinicopathological features and prognosis in patients with periocular sebaceous gland carcinoma.
  • METHODS: Retrospectively, we studied the records of 24 cases of sebaceous gland carcinoma treated in our clinic between 1999 and 2004.
  • The reviewed data included demographic information, initial clinical and histopathological diagnosis, anatomic tumor location, details of treatment, tumor involvement of resection margin, and outcomes such as local recurrence, distant metastasis and survival.
  • RESULTS: Local recurrence developed in 6 cases (25%) at a median of 20 months from initial diagnosis.
  • Only 2 patients (8.3%) died of systemic metastasis to brain and bone from primary lacrimal gland carcinoma.
  • Early aggressive management is required in sebaceous gland carcinoma of the lacrimal gland, as its mortality is much higher than that of eyelid origin.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Eyelid Neoplasms / pathology. Eyelid Neoplasms / surgery. Sebaceous Gland Neoplasms / pathology. Sebaceous Gland Neoplasms / surgery

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17728556.001).
  • [ISSN] 1423-0267
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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50. Ohnishi T, Watanaba S: [Classification and diagnosis of sebaceous gland and sweat gland neoplasms]. Gan To Kagaku Ryoho; 2009 Apr;36(4):585-7
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  • [Title] [Classification and diagnosis of sebaceous gland and sweat gland neoplasms].
  • [MeSH-major] Sebaceous Gland Neoplasms / classification. Sebaceous Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / classification. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / classification. Adenocarcinoma / diagnosis. Humans. Prognosis

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  • (PMID = 19408419.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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51. Xu XL, Li B, Sun XL, Li LQ, Ren RJ, Gao F, Jonas JB: Eyelid neoplasms in the Beijing Tongren Eye Centre between 1997 and 2006. Ophthalmic Surg Lasers Imaging; 2008 Sep-Oct;39(5):367-72
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  • RESULTS: Of the 2,639 eyelid specimens, 2,276 (86.2%) were benign and 363 (13.8%) were malignant.
  • The most common malignant or semi-malignant tumors were basal cell carcinomas, sebaceous gland carcinomas, lymphomas, squamous cell carcinomas, and malignant melanomas.
  • The mean age at diagnosis was 41 years for benign lesions and 60 years for malignant tumors.
  • CONCLUSION: At the BeijingTongren Eye Centre between 1997 and 2006, the predominant non-benign eyelid tumors were basal cell carcinoma and sebaceous gland carcinoma, followed by lymphoma.

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  • (PMID = 18831417.001).
  • [ISSN] 1542-8877
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Kazakov DV, Kutzner H, Spagnolo DV, Rütten A, Mukensnabl P, Michal M: What is extraocular cutaneous sebaceous carcinoma in situ? Am J Dermatopathol; 2010 Dec;32(8):857-8
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  • [Title] What is extraocular cutaneous sebaceous carcinoma in situ?
  • [MeSH-major] Carcinoma / classification. Carcinoma in Situ / classification. Sebaceous Gland Neoplasms / classification. Terminology as Topic

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  • [CommentOn] Am J Dermatopathol. 2010 Dec;32(8):854-5 [20885288.001]
  • (PMID = 20966738.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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53. Song A, Carter KD, Syed NA, Song J, Nerad JA: Sebaceous cell carcinoma of the ocular adnexa: clinical presentations, histopathology, and outcomes. Ophthal Plast Reconstr Surg; 2008 May-Jun;24(3):194-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous cell carcinoma of the ocular adnexa: clinical presentations, histopathology, and outcomes.
  • PURPOSE: To investigate the clinical features, time to diagnosis, histopathology, treatment, and mortality rates of patients with sebaceous cell carcinoma.
  • METHODS: This was a retrospective, consecutive series of patients with sebaceous cell carcinoma at a tertiary referral medical center.
  • Between January 1984 and January 2006, 31 patients with sebaceous cell carcinoma were evaluated at the Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics.
  • RESULTS: Thirty-one patients were diagnosed with sebaceous cell carcinoma of the ocular adnexa on histopathology.
  • Twenty-three patients had in situ disease, pagetoid disease, or both.
  • Eight patients reported symptoms for <6 months and 22 had symptoms for < or = 12 months before the diagnosis of sebaceous cell carcinoma was made.
  • Two patients died from metastatic sebaceous cell carcinoma.
  • CONCLUSIONS: Sebaceous cell carcinoma has varied presentations and is commonly misdiagnosed.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 18520834.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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54. Rath S, Honavar SG, Reddy VA, Naik MN, Vemuganti GK, Murthy R: Sebaceous carcinoma of the eyelid metastasizing to the lacrimal sac after 5 years. Orbit; 2009;28(5):309-12
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  • [Title] Sebaceous carcinoma of the eyelid metastasizing to the lacrimal sac after 5 years.
  • Eyelid sebaceous carcinoma metastasizing to lacrimal sac is rare.
  • Histopathology confirmed it to be sebaceous carcinoma with uninvolved margins.
  • Repeat excision biopsy and conjunctival map biopsy confirmed recurrent sebaceous carcinoma of the lacrimal sac.
  • [MeSH-major] Adenocarcinoma, Sebaceous / surgery. Eyelid Neoplasms / surgery. Neoplasm Recurrence, Local / surgery

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  • (PMID = 19874127.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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55. Priyadarshini O, Biswas G, Biswas S, Padhi R, Rath S: Neoadjuvant chemotherapy in recurrent sebaceous carcinoma of eyelid with orbital invasion and regional lymphadenopathy. Ophthal Plast Reconstr Surg; 2010 Sep-Oct;26(5):366-8
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  • [Title] Neoadjuvant chemotherapy in recurrent sebaceous carcinoma of eyelid with orbital invasion and regional lymphadenopathy.
  • Histopathology showed it to be invasive sebaceous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Eyelid Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy. Orbital Neoplasms / drug therapy. Sebaceous Gland Neoplasms / drug therapy

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  • (PMID = 20856079.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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56. Cibull TL, Thomas AB, Badve S, Billings SD: Sebaceous carcinoma of the nipple. J Cutan Pathol; 2008 Jun;35(6):608-10
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  • [Title] Sebaceous carcinoma of the nipple.
  • Sebaceous carcinoma (SC) is an uncommon neoplasm that usually presents as an ocular or extraocular cutaneous lesion of the head and neck.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Breast Neoplasms / pathology. Nipples / pathology
  • [MeSH-minor] Aged, 80 and over. Disease-Free Survival. Female. Humans. Treatment Outcome

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  • (PMID = 18466364.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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57. Bogner PN, Su LD, Fullen DR: Cluster designation 5 staining of normal and non-lymphoid neoplastic skin. J Cutan Pathol; 2005 Jan;32(1):50-4
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  • The majority of benign and malignant apocrine lesions demonstrated strong focal (36%, n=11)-to-diffuse (64%, n=16) staining.
  • Microcystic adnexal carcinoma demonstrated focal staining of deeper ductal structures (71%, n=7), whereas desmoplastic trichoepithelioma and basal cell carcinoma showed only rare positive cells.
  • All cases of mammary (n=7) and extramammary (n=8) Paget's disease labeled diffusely for CD5.
  • Pagetoid Bowen's disease (n=6), intraepidermal sebaceous carcinoma (n=3), nor melanoma in situ (n=6) showed any CD5 staining.
  • CONCLUSIONS: Immunohistochemical staining for CD5 is extremely useful in the differential diagnosis of pagetoid epidermal lesions and will mark mammary and extramammary Paget's disease, but not pagetoid Bowen's disease, melanoma in situ, or sebaceous carcinoma.
  • [MeSH-minor] Cell Count. Diagnosis, Differential. Humans. Immunohistochemistry. Paget Disease, Extramammary / diagnosis. Paget's Disease, Mammary / diagnosis. Retrospective Studies

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  • (PMID = 15660655.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD5
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58. Chang SC, Liao JW, Wong ML, Lai YS, Liu CI: Mammary carcinoma with sebaceous differentiation in a dog. Vet Pathol; 2007 Jul;44(4):525-7
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  • [Title] Mammary carcinoma with sebaceous differentiation in a dog.
  • This report describes an invasive mammary carcinoma with a rare distinctive feature characterized by sebaceous differentiation of tumor cells.
  • The patient had two masses in the left fifth mammary gland.
  • Microscopically, the tumors were composed of two distinctive neoplastic components, intraductal papillary adenocarcinoma and sebaceous carcinoma.
  • The regions of sebaceous tumor were clumped separately, contained well-developed sebaceous cells and keratinized epithelial cells, and were surrounded by few to several layers of basaloid cells.
  • The cells with abundant foamy cytoplasm that resembled sebaceous cells were also found within the intraductal papillary-like nests of mammary carcinoma, providing evidence of sebaceous metaplasia.
  • Sebaceous differentiation in a mammary gland tumor is possible, because skin appendages and ductal apparatus of the mammary gland share a common anlagen.
  • [MeSH-major] Mammary Neoplasms, Animal / pathology. Sebaceous Glands / pathology

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  • (PMID = 17606516.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Sawyer AR, McGoldrick RB, Mackey S, Powell B, Pohl M: Should extraocular sebaceous carcinoma be investigated using sentinel node biopsy? Dermatol Surg; 2009 Apr;35(4):704-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Should extraocular sebaceous carcinoma be investigated using sentinel node biopsy?
  • [MeSH-major] Nose Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology. Sentinel Lymph Node Biopsy

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  • (PMID = 19415798.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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60. Al-Shobaili HA, AlGhamdi KM, Al-Ghamdi WA: Cystic sebaceous carcinoma: is it a constant pathognomic marker for Muir-Torre syndrome? J Drugs Dermatol; 2007 May;6(5):540-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic sebaceous carcinoma: is it a constant pathognomic marker for Muir-Torre syndrome?
  • Sebaceous carcinoma (SC) is a rare and aggressive cutaneous neoplasm.
  • Cystic presentation of sebaceous neoplasm is rare.
  • So far, cystic sebaceous neoplasia (CSN) has been reported only in association with Muir-Torre syndrome (MTS).
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Neoplasms, Cystic, Mucinous, and Serous / pathology. Skin Neoplasms / pathology

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  • (PMID = 17679191.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Seethala RR, Richmond JA, Hoschar AP, Barnes EL: New variants of epithelial-myoepithelial carcinoma: oncocytic-sebaceous and apocrine. Arch Pathol Lab Med; 2009 Jun;133(6):950-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New variants of epithelial-myoepithelial carcinoma: oncocytic-sebaceous and apocrine.
  • CONTEXT: Recently described variants of epithelial-myoepithelial carcinoma have not been well characterized but raise a distinct set of differential diagnostic considerations than the classic type.
  • OBJECTIVE: To report a detailed analysis of oncocytic-sebaceous epithelial-myoepithelial carcinoma (OEMCa) and a similar, but novel, variant, apocrine epithelial-myoepithelial carcinoma (ApEMCa).
  • Available follow-up (n = 6; 3 OEMCas, 3 ApEMCas) shows a favorable course (no evidence of disease; mean, 17.4 months).
  • Both were morphologically similar, but only OEMCa had sebaceous elements.
  • CONCLUSIONS: Oncocytic-sebaceous epithelial-myoepithelial carcinoma and ApEMCa should be considered in the differential diagnosis of oncocytic/oncocytoid salivary gland tumors.
  • Oncocytic-sebaceous epithelial-myoepithelial carcinoma morphology may reflect a senescent phenotype, similar to other oncocytic lesions.
  • The ductal component of ApEMCa shares some similarities with salivary duct carcinoma and supports the notion that epithelial-myoepithelial carcinoma can serve as the progenitor tumor for hybrid tumors.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Apocrine Glands / pathology. Carcinoma / pathology. Myoepithelioma / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Humans. Immunohistochemistry. Microscopy, Electron, Transmission. Middle Aged


62. Shields JA, Shields CL: Sebaceous adenocarcinoma of the eyelid. Int Ophthalmol Clin; 2009;49(4):45-61
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  • [Title] Sebaceous adenocarcinoma of the eyelid.
  • [MeSH-major] Adenocarcinoma, Sebaceous. Eyelid Neoplasms
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Diagnosis, Differential. Humans. Incidence. Prognosis. Risk Factors. United States / epidemiology

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  • (PMID = 20348857.001).
  • [ISSN] 1536-9617
  • [Journal-full-title] International ophthalmology clinics
  • [ISO-abbreviation] Int Ophthalmol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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63. Demirci H, Nelson CC, Shields CL, Eagle RC Jr, Shields JA: Eyelid sebaceous carcinoma associated with Muir-Torre syndrome in two cases. Ophthal Plast Reconstr Surg; 2007 Jan-Feb;23(1):77-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eyelid sebaceous carcinoma associated with Muir-Torre syndrome in two cases.
  • We report the rare but serious association between sebaceous carcinoma of eyelid and Muir-Torre syndrome in two cases, a 79-year-old woman and 54-year-old man.
  • A history of multiple primary colon cancers was present in both patients, associated transitional cell carcinoma of bladder and renal cancer in one patient and prostate cancer in the other.
  • Histopathology revealed sebaceous carcinoma of eyelid and conjunctiva.
  • Muir-Torre syndrome was diagnosed on the basis of sebaceous carcinoma, associated with multiple visceral malignancies in both patients.
  • We conclude that patients with sebaceous carcinoma should have evaluation for visceral malignancies, mainly colon cancer.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Transitional Cell. Colonic Neoplasms / pathology. Cryotherapy. Female. Humans. Kidney Neoplasms / pathology. Male. Middle Aged. Urinary Bladder Neoplasms / pathology

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  • (PMID = 17237705.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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64. Dixon A: Rare skin cancers in general practice. Aust Fam Physician; 2007 Mar;36(3):141-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histology of the superior lesion revealed sebaceous carcinoma.
  • This is an uncommon yet aggressive cutaneous malignancy derived from sebaceous glands.
  • [MeSH-major] Skin Neoplasms / diagnosis. Skin Neoplasms / therapy
  • [MeSH-minor] Australia. Family Health. Family Practice. Humans. Male. Neoplasms, Radiation-Induced / diagnosis. Neoplasms, Radiation-Induced / therapy. Sarcoma / diagnosis. Sarcoma / therapy. Sebaceous Gland Neoplasms / diagnosis. Sebaceous Gland Neoplasms / therapy

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  • (PMID = 17339977.001).
  • [ISSN] 0300-8495
  • [Journal-full-title] Australian family physician
  • [ISO-abbreviation] Aust Fam Physician
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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65. Rizvi SA, Maheshwari V: Advanced upper eyelid sebaceous gland carcinoma with deep orbital extension. J Surg Case Rep; 2010;2010(1):5
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  • [Title] Advanced upper eyelid sebaceous gland carcinoma with deep orbital extension.
  • Sebaceous gland carcinomas (SGC) are highly malignant lid tumors which originate from meibomian glands and rarely from the gland of Zeis, sebaceous gland of caruncle, eyebrows and periocular skin.
  • In many cases correct diagnosis of SGC is delayed because of its ability to masquerade as a variety of other ocular conditions.
  • A differential diagnosis of sebaceous gland carcinoma or preseptal cellulitis was made.
  • A diagnosis of meibomian gland carcinoma was confirmed on histopathology.
  • This is a report of an advanced sebaceous gland carcinoma with deep orbital extension.
  • An early diagnosis and appropriate treatment may decrease the long term morbidity and extend the survival rate of such patients.

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  • [Copyright] © JSCR.
  • (PMID = 24945508.001).
  • [ISSN] 2042-8812
  • [Journal-full-title] Journal of surgical case reports
  • [ISO-abbreviation] J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3649079
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66. Carvalho J, Fullen D, Lowe L, Su L, Ma L: The expression of CD23 in cutaneous non-lymphoid neoplasms. J Cutan Pathol; 2007 Sep;34(9):693-8
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  • CD23 staining was seen in 42% (8/19) of microcystic adnexal carcinoma (MAC), while no staining was observed in tumor cells of desmoplastic trichoepithelioma, morpheaform basal cell carcinoma and syringoma.
  • All mammary and extramammary Paget's disease were labeled with CD23.
  • In comparison, pagetoid Bowen's disease, melanoma in situ and sebaceous carcinoma exhibited negative staining.
  • In addition, CD23 reacted diffusely with cutaneous mucinous eccrine carcinoma in a manner similar to breast or colonic adenocarcinoma.
  • CONCLUSION: CD23 appears to be a reliable immunohistochemical marker of the eccrine/apocrine secretory coil and helpful in identifying sweat gland tumors of such origin.
  • CD23 is a useful addition to the diagnostic immunohistochemical panels for Paget's disease.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Receptors, IgE / metabolism. Sweat Gland Neoplasms / metabolism

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  • (PMID = 17696916.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, IgE
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67. Güerrissi JO, Quiroga JP: Adnexal carcinomas of the head and neck. Indian J Plast Surg; 2008 Jul;41(2):229-34
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  • Adnexal carcinomas of the skin are rare and they derive from structures such as sweat glands, sebaceous glands, and hair follicles.
  • Between 1998 and 2004, eight patients with malignant adnexal tumors of the head and neck were treated in the Plastic Surgery Service in Argerich Hospital in Buenos Aires, Argentina.
  • Four (50%) of them had malignant cylindromas, two (25%) had sebaceous carcinoma, and the other two (25%) syringoid eccrine carcinoma.

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  • [Cites] Dermatologica. 1980;160(6):361-70 [6248388.001]
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  • (PMID = 19753272.001).
  • [ISSN] 0970-0358
  • [Journal-full-title] Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • [ISO-abbreviation] Indian J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2740523
  • [Keywords] NOTNLM ; Adnexal carcinomas / adnexal tumors / skin cancer
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68. Bettini G, Morini M, Mandrioli L, Capitani O, Gandini G: CNS and lung metastasis of sebaceous epithelioma in a dog. Vet Dermatol; 2009 Aug;20(4):289-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CNS and lung metastasis of sebaceous epithelioma in a dog.
  • Sebaceous epithelioma is a common canine cutaneous neoplasm characterized by a preponderance of basaloid cells with few well-differentiated sebocytes.
  • This case report presents the clinical and pathological features of a sebaceous epithelioma of the upper lip with a highly aggressive behaviour.
  • The patient was a 9-year-old female dachshund that developed local recurrence 11 months after the excision of the primary sebaceous epithelioma and multiple lung and central nervous system metastases 5 months later.
  • The designation epitheliomatous sebaceous carcinoma has been suggested for aggressive sebaceous epitheliomas, although differential criteria are still to be determined.
  • [MeSH-major] Brain Neoplasms / veterinary. Carcinoma / veterinary. Dog Diseases / pathology. Lung Neoplasms / veterinary. Skin Neoplasms / veterinary

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  • (PMID = 19552699.001).
  • [ISSN] 1365-3164
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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69. Ramljak V, Sarcević B, Vrdoljak DV, Kelcec IB, Agai M, Ostović KT: Fine needle aspiration cytology in diagnosing rare breast carcinoma--two case reports. Coll Antropol; 2010 Mar;34(1):201-5
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  • [Title] Fine needle aspiration cytology in diagnosing rare breast carcinoma--two case reports.
  • In this paper, we are presenting the two cases of very rare tumors: breast sebaceous carcinoma, which has been described for the first time in Croatian medical literature, and pure breast squamous carcinoma.
  • First case, sebaceous carcinoma, is still quite unknown regarding its morphological characteristics and biological behavior.
  • In the second case, squamous carcinoma, also very rare, was found in a patient who previously had a number of diagnosed head and neck skin carcinomas, and was diagnosed as primary squamous breast carcinoma.
  • The second one, a 69-year-old female presented to our hospital in January 2008 with a two months history of a lump in the lower outer region of the left breast and enlarged lymph nodes in left axillary region.
  • This methodology was found important in diagnosis, but in both cases showed certain limitations in diagnosing such rare tumors.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biopsy, Fine-Needle. Breast Neoplasms / pathology. Carcinoma, Squamous Cell / pathology

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  • (PMID = 20432752.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / May-Grunwald Giemsa; T42P99266K / Methylene Blue; TDQ283MPCW / Eosine Yellowish-(YS)
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70. Ho VH, Ross MI, Prieto VG, Khaleeq A, Kim S, Esmaeli B: Sentinel lymph node biopsy for sebaceous cell carcinoma and melanoma of the ocular adnexa. Arch Otolaryngol Head Neck Surg; 2007 Aug;133(8):820-6
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  • [Title] Sentinel lymph node biopsy for sebaceous cell carcinoma and melanoma of the ocular adnexa.
  • OBJECTIVE: To provide clinical details and long-term outcome data for a series of patients with eyelid or conjunctival melanoma or eyelid sebaceous cell carcinoma who underwent sentinel lymph node (SLN) biopsy.
  • PATIENTS: Twenty-five consecutive patients treated at 1 institution for eyelid or conjunctival melanoma or eyelid sebaceous cell carcinoma from December 2000 to October 2004.
  • RESULTS: Seven patients had conjunctival melanoma, 8 had eyelid-margin melanoma with a considerable palpebral conjunctival component, and 10 had eyelid sebaceous cell carcinoma.
  • Two patients with eyelid melanoma and 2 patients with eyelid sebaceous cell carcinoma had negative findings from SLN biopsy but developed recurrence in their regional lymph nodes during the follow-up period.
  • Overall, during follow-up, 2 of 10 patients with sebaceous cell carcinoma (20%) and 5 of 15 patients with eyelid or conjunctival melanoma (33%) had regional lymph node metastasis.
  • Two patients with sebaceous cell carcinoma--1 with regional metastasis and 1 without--developed distant organ metastasis.
  • CONCLUSIONS: The detection of histologically positive SLNs in this series of patients may justify further study of SLN biopsy for high-risk patients with ocular adnexal melanoma or eyelid sebaceous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eye Neoplasms / pathology. Melanoma / pathology. Sebaceous Gland Neoplasms / pathology. Sentinel Lymph Node Biopsy

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  • (PMID = 17709624.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Samarasinghe V, Marsden J, Roberts C: Sebaceous carcinoma of the scalp presenting with nodal metastasis. J Plast Reconstr Aesthet Surg; 2010 Dec;63(12):2193-4
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  • [Title] Sebaceous carcinoma of the scalp presenting with nodal metastasis.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Scalp. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 20558120.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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72. Maheshwari R, Maheshwari S, Shekde S: Role of fine needle aspiration cytology in diagnosis of eyelid sebaceous carcinoma. Indian J Ophthalmol; 2007 May-Jun;55(3):217-9
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  • [Title] Role of fine needle aspiration cytology in diagnosis of eyelid sebaceous carcinoma.
  • Sebaceous carcinoma of the ocular adnexa is a malignant neoplasm which can exhibit aggressive local behavior and can metastasize to regional lymph nodes and distant organs.
  • The neoplasm is known to masquerade as other benign and less malignant lesions, resulting in delay in diagnosis and relative high morbidity and mortality.
  • Subsequently histopathology confirmed the diagnosis of sebaceous gland carcinoma.
  • The article highlights the role of FNAC in early diagnosis and subsequent appropriate surgical management of eyelid sebaceous gland carcinoma to prevent recurrence and metastasis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biopsy, Fine-Needle. Eyelid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged, 80 and over. Early Diagnosis. Female. Humans. Male. Middle Aged

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  • (PMID = 17456941.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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73. Ornellas AA, Frota R, Lopes da Silva LF, Dauster B, Quirino R, de Santos Schwindt AB, Pereira MR: Sebaceous carcinoma of the penis. Urol Int; 2009;82(4):477-80
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  • [Title] Sebaceous carcinoma of the penis.
  • Sebaceous carcinoma is a very aggressive malignant tumor, derived from the adnexal epithelium of sebaceous glands.
  • Extraocular sebaceous carcinoma is a very uncommon neoplasm usually localized on the head and neck.
  • To our knowledge, there are only 2 previously reported cases of sebaceous carcinoma on the penis.
  • We report the clinicopathologic data on 3 additional cases of sebaceous carcinoma arising in the penis.
  • [MeSH-major] Carcinoma. Penile Neoplasms

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19506419.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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74. Tohya T, Ogura T, Nishi K, Nishi H, Kuriwaki K: Muir-Torre syndrome associated with endometrial carcinoma. Int J Clin Oncol; 2008 Dec;13(6):559-61
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  • [Title] Muir-Torre syndrome associated with endometrial carcinoma.
  • Muir-Torre syndrome (MTS) is an autosomaldominant skin condition of genetic origin, characterized by tumors of the sebaceous glands or keratoacanthomas that are associated with malignant visceral diseases.
  • Here we report a woman with no family history of colorectal cancer who developed endometrial carcinoma, stage 3a, at 49 years of age and at age 51 years, developed two skin tumors, a nasal squamous cell carcinoma and a sebaceous carcinoma of the right eyelid.
  • Although MTS associated with endometrial carcinoma is rare, patients with endometrial carcinoma should undergo evaluation for visceral malignancies (mainly colon cancer) and sebaceous skin lesions, regardless of whether or not there is a family history of colorectal cancer.

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  • [Cites] Int J Dermatol. 2006 Mar;45(3):311-3 [16533237.001]
  • [Cites] Cancer. 2005 Mar 1;103(5):1018-25 [15662714.001]
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  • (PMID = 19093187.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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75. Warnecke KK, Sieg P: [Sebaceous carcinoma of the eyelids--case reports and review of the literature]. Klin Monbl Augenheilkd; 2006 Sep;223(9):771-4
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  • [Title] [Sebaceous carcinoma of the eyelids--case reports and review of the literature].
  • BACKGROUND: Sebaceous carcinomas are among the most rarely found skin tumours (0.2 - 4.6 %).
  • The cytological origins are foremost the Meibomian and the glands of Zeis.
  • CASE REPORTS: We report on two female patients suffering from sebaceous carcinoma of the upper and lower lid.
  • The time span from initial treatment up to definite diagnosis and treatment was one year.
  • In the second case a lymph node metastasis of the parotid gland was found seven years after initial therapy and surgically removed followed by a complete parotidectomy and neck dissection.
  • DISCUSSION: As the sebaceous carcinomas are difficult to differentiate from other kinds of benign and malignant eyelid diseases, a considerable delay between the initial examination and final diagnosis is not uncommon.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Eyelid Neoplasms / surgery. Skin Neoplasms / pathology

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  • (PMID = 16986089.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 28
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76. Kazakov DV, Calonje E, Zelger B, Luzar B, Belousova IE, Mukensnabl P, Michal M: Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases. Am J Dermatopathol; 2007 Jun;29(3):242-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases.
  • The authors report a small series of sebaceous carcinoma developing in nevus sebaceus of Jadassohn (also known as organoid nevus) and analyze similar cases reported in the literature.
  • All sebaceous carcinomas manifested unquestionable architectural (asymmetry, invasive growth) and cytological features of a carcinoma (cellular and nuclear pleomorphism, plentiful atypical mitoses, necroses en masse), demonstrated unambiguous sebaceous differentiation in the form of mature sebocytes, and lacked other differentiations.
  • The sebaceous carcinoma was always accompanied by other benign or malignant adnexal lesions such as sebaceoma, syringocystadenoma papilliferum, syringocystadenocarcinoma papilliferum, trichoblastoma, tricholemmoma, desmoplastic tricholemmoma, or syringoma.
  • The analysis of the previously published material and our cases indicates that sebaceous carcinoma arising in organoid nevus has a female predilection and tends to occur in elderly patients.
  • It may involve any site where nevus sebaceus typically occurs.
  • It may arise alone, but it occurs more frequently as part of multiple benign and malignant adnexal tumors.
  • The tumor seems to be a low-grade carcinoma in terms of clinical behavior.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 17519621.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Khong JJ, Leibovitch I, Selva D, Dodd T, Muecke J: Sebaceous gland carcinoma of the eyelid presenting as a conjunctival papilloma. Clin Exp Ophthalmol; 2005 Apr;33(2):197-8
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  • [Title] Sebaceous gland carcinoma of the eyelid presenting as a conjunctival papilloma.
  • An unusual presentation of sebaceous carcinoma of the eyelid is described in a 96-year-old man who presented with a large papillomatous palpebral conjunctival lesion in the left upper eyelid.
  • Histopathology revealed a sebaceous gland carcinoma with no evidence of pagetoid spread.
  • Although rare, sebaceous gland carcinoma should be considered in the differential diagnosis of a conjunctival papilloma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Conjunctival Neoplasms / pathology. Eyelid Neoplasms / diagnosis. Papilloma / pathology. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Humans. Male

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  • (PMID = 15807833.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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78. Altemani A, Vargas PA, Cardinali I, Aguiar SS, Lopes M, Soares AB, Speight PM, Almeida OP: Sebaceous carcinoma of the parotid gland in children: an immunohistochemical and ploidy study. Int J Oral Maxillofac Surg; 2008 May;37(5):433-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the parotid gland in children: an immunohistochemical and ploidy study.
  • Sebaceous carcinoma (SC) is a rare malignancy, affecting mainly the periocular glands.
  • The CK14 pattern depicted the monolayer of basal cells surrounding the islands of malignant tissue, while the more central sebaceous differentiated cells were negative.
  • Epithelial membrane antigen was strongly positive in the well differentiated cells, while most of the basaloid peripheral cells were negative, and only a few cells were positive for carcinoembryonic antigen. beta catenin, E cadherin and C-erb B2 were expressed by most of the cells including the more differentiated sebaceous cells.
  • [MeSH-major] Adenocarcinoma, Sebaceous / chemistry. Parotid Neoplasms / chemistry

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  • (PMID = 18396014.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Cadherins; 0 / Keratin-14; 0 / Keratin-18; 0 / Keratin-19; 0 / Mucin-1; 0 / beta Catenin; EC 2.7.10.1 / Receptor, ErbB-2
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79. Lukáts O: [Oncological principles of surgery in the periorbital region]. Magy Onkol; 2005;49(1):47-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study is to describe the most common malignant periorbital tumours and principles of their surgical treatment.
  • The most common malignant tumours of the eyelids are: basocellular carcinoma, squamocellular carcinoma, sebaceous carcinoma and malignant melanoma.
  • Malignant tumours of the eyelids are fairly rare.
  • Diagnosis in some of the cases is difficult, since the first signs of the tumours are small changes on the eyelid margin or eyelid skin.
  • Focal loss of the eyelashes could be the first sign of a malignant tumour.
  • Therefore, early diagnosis and total tumour removal--regardless of the anatomical borders--as well as immediate reconstruction are important in the treatment of eyelid tumours.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / surgery. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Humans. Melanoma / surgery. Ophthalmologic Surgical Procedures / methods. Sebaceous Gland Neoplasms / surgery. Surgical Procedures, Operative / methods

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  • (PMID = 15902334.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Number-of-references] 23
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80. Hoffmann M, Braun-Falco M: Rhinophyma-like sebaceous carcinoma. J Eur Acad Dermatol Venereol; 2009 Oct;23(10):1216-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rhinophyma-like sebaceous carcinoma.
  • [MeSH-major] Rhinophyma / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 19368609.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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81. Samaila MO: Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med; 2008 Mar;7(1):6-10
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  • Only two cases had a clinical diagnosis of adnexal tumor.
  • Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas.
  • Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma.
  • Forty-six lesions (88.5%) were benign and six (11.5%) malignant.
  • The commonest variants are those of eccrine sweat gland origin.
  • Malignant adnexal tumors are uncommon in our setting.
  • [MeSH-major] Carcinoma, Skin Appendage / classification. Neoplasms, Adnexal and Skin Appendage / classification
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / pathology. Adenoma, Sweat Gland / epidemiology. Adenoma, Sweat Gland / pathology. Adolescent. Adult. Aged. Child. Child, Preschool. Female. Hair Follicle / pathology. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / pathology. Humans. Infant, Newborn. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / pathology. Sweat Gland Neoplasms / epidemiology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18702242.001).
  • [ISSN] 1596-3519
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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82. Calder KB, Khalil FK, Schlauder S, Cualing HD, Morgan MB: Immunohistochemical expression of survivin in cutaneous sebaceous lesions. Am J Dermatopathol; 2008 Dec;30(6):545-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of survivin in cutaneous sebaceous lesions.
  • Survivin overexpression has been demonstrated in numerous malignancies including cutaneous squamous cell carcinoma and melanoma.
  • To date, there are no studies evaluating the expression of survivin in sebaceous neoplasms.
  • METHODS: Immunohistochemical expression of survivin was evaluated in a total of 20 extraocular sebaceous neoplasms: sebaceous hyperplasia (SH, 8), sebaceous adenoma (SA, 8), and sebaceous carcinoma (SC, 4).
  • These findings demonstrate the potential diagnostic utility of survivin, further assisting in the microscopic differentiation of benign and malignant sebaceous neoplasms.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Adenoma / metabolism. Microtubule-Associated Proteins / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Glands / metabolism. Sebaceous Glands / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Case-Control Studies. Cell Nucleus / metabolism. Diagnosis, Differential. Female. Humans. Hyperplasia / diagnosis. Hyperplasia / metabolism. Hyperplasia / pathology. Inhibitor of Apoptosis Proteins / metabolism. Male. Middle Aged

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  • (PMID = 19033926.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
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83. Fernandes BF, Martins CM, Heckler LV, Arthurs B, Codère F, Burnier MN Jr: Sebaceous carcinoma of the eyelid. ANZ J Surg; 2009 Apr;79(4):306-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the eyelid.
  • [MeSH-major] Eyelid Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis

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  • [CommentOn] ANZ J Surg. 2008 Mar;78(3):158-63 [18269479.001]
  • (PMID = 19432724.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Australia
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84. Heyl J, Mehregan D: Immunolabeling pattern of cytokeratin 19 expression may distinguish sebaceous tumors from basal cell carcinomas. J Cutan Pathol; 2008 Jan;35(1):40-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunolabeling pattern of cytokeratin 19 expression may distinguish sebaceous tumors from basal cell carcinomas.
  • BACKGROUND: Distinction between sebaceous tumors and basal cell carcinomas can often pose diagnostic problems.
  • Our aim was to evaluate the use of CK 19 staining patterns in differentiating between sebaceous tumors and basal cell carcinomas.
  • The sebaceous tumors that were examined in this study included sebaceous adenomas, sebaceous epitheliomas (sebaceomas) and sebaceous carcinomas.
  • METHODS: Thirty-seven cases including 5 sebaceous adenomas, 16 sebaceous epitheliomas, 6 sebaceous carcinomas and 14 basal cell carcinomas (7 being of the morpheaform type and 7 nodular basal cell carcinomas) were tested with a monoclonal mouse antibody to human CK 19.
  • RESULTS: CK 19 was focally positive in 1/5 (20%) sebaceous adenomas, 8/16 (50%) of sebaceous epitheliomas and 1/6 (17%) of sebaceous carcinomas.
  • Strongly positive expression of CK 19 was not seen in any of the sebaceous adenoma, sebaceous epithelioma or sebaceous carcinoma specimens.
  • CONCLUSION: CK 19 expression can be helpful in differentiating sebaceous tumors (including sebaceous adenomas, sebaceous epitheliomas and sebaceous carcinomas) from basal cell carcinomas and may be a useful adjunct when these entities are included in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Adenoma / diagnosis. Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Keratin-19 / analysis. Sebaceous Gland Neoplasms / diagnosis. Sebaceous Glands / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Humans. Middle Aged

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  • (PMID = 18095993.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-19
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85. Tanyi M, Olasz J, Lukács G, Tanyi JL, Tóth L, Antal-Szalmás P, Ress Z, Bubán T, András C, Damjanovich L: A new mutation in Muir-Torre syndrome associated with familiar transmission of different gastrointestinal adenocarcinomas. Eur J Surg Oncol; 2009 Oct;35(10):1128-30
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  • [Title] A new mutation in Muir-Torre syndrome associated with familiar transmission of different gastrointestinal adenocarcinomas.
  • Hereditary Nonpolyposis Colorectal Carcinoma (HNPCC) is the most frequent inherited disease which can lead to the development of tumors in the colon and other locations.
  • Muir-Torre syndrome is considered one of the subtypes of this disease, in which the HNPCC tumor spectrum is frequently associated with sebaceous carcinoma of the skin or keratoacanthoma.
  • A 57 years old male patient is presented with a mucinous carcinoma of the caecum and an adenocarcinoma of the pancreas head.
  • A malignant sebaceous carcinoma was removed from his left neck area.
  • His family history was significant for two cases of colon carcinoma, two cases of stomach cancer and a case of metacron endometrial and skin tumor as well.
  • Both the colon carcinoma and the skin tumor proved to be microsatellite unstable.
  • In cases of sebaceous skin lesions, evaluation of family history is of utmost importance in the early detection of HNPCC and in the follow up care of family members with the particular mutation.
  • [MeSH-minor] Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / pathology. Cecal Neoplasms / genetics. Cecal Neoplasms / pathology. Family Health. Humans. Male. Middle Aged. Pancreatic Neoplasms / genetics. Pancreatic Neoplasms / pathology. Pedigree

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  • (PMID = 19423266.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins
  • [Number-of-references] 15
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86. Moshitch-Moshkovitz S, Tsarfaty G, Kaufman DW, Stein GY, Shichrur K, Solomon E, Sigler RH, Resau JH, Vande Woude GF, Tsarfaty I: In vivo direct molecular imaging of early tumorigenesis and malignant progression induced by transgenic expression of GFP-Met. Neoplasia; 2006 May;8(5):353-63
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  • [Title] In vivo direct molecular imaging of early tumorigenesis and malignant progression induced by transgenic expression of GFP-Met.
  • These mice ubiquitously expressed GFP-Met in specific epithelial and endothelial cells and displayed enhanced GFP-Met fluorescence in sebaceous glands.
  • Thirty-two percent of males spontaneously developed adenomas, adenocarcinomas, and angiosarcomas in their lower abdominal sebaceous glands.
  • Approximately 70% of adenocarcinoma tumors metastasized to the kidneys, lungs, or liver.
  • Quantitative subcellular-resolution intravital imaging revealed very high levels of GFP-Met in tumor lesions and in single isolated cells surrounding them, relative to normal sebaceous glands.

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  • (PMID = 16790084.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA093990; United States / NCI NIH HHS / CA / P50CA93990
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 147336-22-9 / Green Fluorescent Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-met
  • [Other-IDs] NLM/ PMC1592452
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87. Jahagirdar SS, Thakre TP, Kale SM, Kulkarni H, Mamtani M: A clinicopathological study of eyelid malignancies from central India. Indian J Ophthalmol; 2007 Mar-Apr;55(2):109-12
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  • In the same case series, we also include a case of malignant hemangiopericytoma which is an extremely rare form of eyelid malignancy worldwide.
  • RESULTS: We observed that sebaceous cell carcinoma (approximately 37%) was almost as prevalent as basal cell carcinoma (approximately 44%) in the study subjects and had an earlier age of occurrence and a more rapid clinical course.
  • CONCLUSIONS: Sebaceous cell carcinoma of the eyelid is almost as common as basal cell carcinoma in a large tertiary care centre in central India.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / pathology. Adenocarcinoma, Sebaceous / surgery. Biopsy, Fine-Needle. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Diagnosis, Differential. Female. Hemangiopericytoma / epidemiology. Hemangiopericytoma / pathology. Hemangiopericytoma / surgery. Humans. India / epidemiology. Male. Middle Aged. Neoplasm Staging. Ophthalmologic Surgical Procedures / methods. Prevalence. Prognosis. Retrospective Studies

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  • (PMID = 17322599.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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88. Kaur G, Ismail R, Harun H: Metastatic mucinous carcinoma of the eyelid. Malays J Pathol; 2005 Dec;27(2):117-8
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  • [Title] Metastatic mucinous carcinoma of the eyelid.
  • We report a case of metastatic breast carcinoma to the eyelid in a 60-year-old Chinese lady presenting with a 2-year history of enlarging, painless nodular lower eyelid swelling.
  • The 1 cm diameter lesion was provisionally diagnosed as a sebaceous cyst.
  • However the excision biopsy revealed a mucinous carcinoma expressing oestrogen receptor protein.
  • She had a past history of mastectomy one year previously and histology showed an infiltrating ductal carcinoma (oestrogen receptor status negative) without evidence of axillary lymph node metastasis.
  • We highlight this case to create awareness among clinicians and opthalmologists on the possibility of metastatic disease as a cause of eyelid swelling, especially in patients with a history of cancer.
  • It may also be the first sign of metastatic disease of an internal malignancy.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / secondary. Eyelid Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Diagnosis, Differential. Epidermal Cyst / pathology. Female. Humans. Immunohistochemistry. Malaysia. Middle Aged. Receptors, Estrogen / metabolism

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  • (PMID = 17191395.001).
  • [ISSN] 0126-8635
  • [Journal-full-title] The Malaysian journal of pathology
  • [ISO-abbreviation] Malays J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Malaysia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Receptors, Estrogen
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89. Khong JJ, Muecke J: Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia. Br J Ophthalmol; 2006 Jul;90(7):819-22
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  • RESULTS: One to three 7 day cycles of topical MMC 0.04% four times a day were given to 59 eyes with localised corneal-conjunctival intraepithelial neoplasia (CIN), 19 eyes with diffuse CIN, six eyes with recurrent CIN, one eye with ocular surface squamous cell carcinoma, three eyes with primary acquired melanosis (PAM) with atypia, nine eyes with conjunctival malignant melanoma (MM), two eyes with sebaceous carcinoma with pagetoid spread, and one eye with recurrent atypical fibroxanthoma.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / drug therapy. Carcinoma in Situ / drug therapy. Carcinoma, Squamous Cell / drug therapy. Conjunctival Neoplasms / drug therapy. Corneal Diseases / drug therapy. Female. Follow-Up Studies. Histiocytoma, Benign Fibrous / drug therapy. Humans. Lacrimal Apparatus Diseases / chemically induced. Lacrimal Duct Obstruction / chemically induced. Male. Melanoma / drug therapy. Melanosis / drug therapy. Retrospective Studies

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  • (PMID = 16672325.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
  • [Other-IDs] NLM/ PMC1857172
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90. Reina RS, Parry E: Aggressive extraocular sebaceous carcinoma in a 52-year-old man. Dermatol Surg; 2006 Oct;32(10):1283-6
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  • [Title] Aggressive extraocular sebaceous carcinoma in a 52-year-old man.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 17034381.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Rawlinson NJ, Almarzooqi S, Nicol K: Sebaceous lymphadenoma of the parotid gland in a 13-year-old girl: a case report. Head Neck Pathol; 2010 Jun;4(2):144-7
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  • [Title] Sebaceous lymphadenoma of the parotid gland in a 13-year-old girl: a case report.
  • Sebaceous lymphadenoma is a benign rare tumor of the salivary gland.
  • The epithelial nests are composed of sebaceous cells and ductal structures.
  • Prognosis is good with rare recurrence or malignant transformation.
  • We report the second case of sebaceous lymphadenoma in the pediatric population and the youngest reported so far that presented in a 13 year old girl with a parotid mass.
  • [MeSH-major] Adenolymphoma / pathology. Parotid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Sebaceous / diagnosis. Adolescent. Carcinoma, Mucoepidermoid / diagnosis. Diagnosis, Differential. Female. Humans. Lymphoma / diagnosis

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  • (PMID = 20512641.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2878632
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92. Nishizawa A, Nakanishi Y, Sasajima Y, Yamazaki N, Yamamoto A: Muir-torre syndrome with intriguing squamous lesions: a case report and review of the literature. Am J Dermatopathol; 2006 Feb;28(1):56-9
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  • Muir-Torre syndrome (MTS) is an autosomal, dominantly inherited disorder characterized by sebaceous neoplasms and visceral malignancies.
  • We report a 56-year-old woman who underwent resections of extraocular sebaceous carcinoma, sebaceous epithelioma, actinic keratosis, and keratoacanthoma (KA)-like squamous cell carcinoma (SCC) with venous invasion metachronously over a 9-year period.
  • Because of the mixed, unusual features of the skin lesions, and her history of endometrial and colorectal cancers that had been resected 12 years and 1 year, respectively, before the present event, a possible diagnosis of Muir-Torre syndrome was suggested.
  • This patient presented with intriguing squamous lesions including keratoacanthoma-like squamous cell carcinoma that showed venous invasion and actinic keratosis, and associated loss of hMSH2 expression, in addition to the sebaceous neoplasms typical of Muir-Torre syndrome.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Sebaceous Gland Neoplasms / pathology. Syndrome
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Cell Nucleus / metabolism. Cell Nucleus / pathology. Female. Humans. Immunohistochemistry. Keratoacanthoma / genetics. Keratoacanthoma / metabolism. Keratoacanthoma / pathology. Loss of Heterozygosity. Middle Aged. MutS Homolog 2 Protein / genetics. MutS Homolog 2 Protein / metabolism

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  • (PMID = 16456327.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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93. Hertel V, Bozzato A, Alexiou C: [Unilateral neck mass, dysphagia and dyspnea]. HNO; 2010 Aug;58(8):818-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extraocular sebaceous carcinoma is a rare malignant tumor, arising from skin and salivary glands.
  • An important differential diagnosis in the head and neck region is metastasizing squamous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Deglutition Disorders / etiology. Dyspnea / etiology. Head and Neck Neoplasms / diagnosis. Hypopharyngeal Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Diagnosis, Differential. Endoscopy. Humans. Keratin-5 / analysis. Male. Pyriform Sinus / pathology. Pyriform Sinus / surgery. Surgical Flaps. Tomography, X-Ray Computed. Tracheotomy. Ultrasonography


94. Pusiol T, Zorzi MG, Piscioli F: Grading of skin sebaceous carcinoma. Hum Pathol; 2010 Mar;41(3):459
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Grading of skin sebaceous carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Sebaceous Gland Neoplasms / pathology

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  • [CommentOn] Hum Pathol. 1982 Feb;13(2):113-22 [7076199.001]
  • (PMID = 20159235.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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95. Harwood CA, Proby CM, Cerio R: Appendageal malignancies. Cancer Treat Res; 2009;146:353-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma, Sebaceous / pathology. Cell Differentiation. Female. Humans. Immune System. Immunosuppressive Agents / therapeutic use. Male. Middle Aged. Models, Biological. Organ Transplantation / adverse effects. Prognosis. Treatment Outcome

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  • (PMID = 19415216.001).
  • [ISSN] 0927-3042
  • [Journal-full-title] Cancer treatment and research
  • [ISO-abbreviation] Cancer Treat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
  • [Number-of-references] 71
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96. Karcioglu ZA: Sebaceous carcinoma of the eyelids. Ophthalmology; 2005 Sep;112(9):1641; author reply 1641-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the eyelids.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology

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  • [CommentOn] Ophthalmology. 2004 Dec;111(12):2151-7 [15582067.001]
  • [CommentOn] Ophthalmology. 2004 Dec;111(12):2149-50 [15582066.001]
  • (PMID = 16139675.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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97. Higgins HJ, Voutsalath M, Holland JM: Muir-torre syndrome: a case report. J Clin Aesthet Dermatol; 2009 Aug;2(8):30-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Muir-Torre syndrome is an autosomal dominant genodermatosis associated with sebaceous neoplasms and visceral malignancies.
  • Characteristic sebaceous neoplasms include sebaceous adenoma, sebaceous carcinoma, sebaceoma, and keratoacanthoma with sebaceous differentiation.
  • The clinical and histological features of a patient with Muir-Torre syndrome who had two sebaceous adenomas, multiple basal cell carcinomas, and frontal bossing in association with colon cancer are presented in this report.

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  • [Cites] Arch Dermatol. 1968 Nov;98(5):549-51 [5684233.001]
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  • (PMID = 20729952.001).
  • [ISSN] 1941-2789
  • [Journal-full-title] The Journal of clinical and aesthetic dermatology
  • [ISO-abbreviation] J Clin Aesthet Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2923964
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98. Russell HC, Chadha V, Lockington D, Kemp EG: Topical mitomycin C chemotherapy in the management of ocular surface neoplasia: a 10-year review of treatment outcomes and complications. Br J Ophthalmol; 2010 Oct;94(10):1316-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: This study is a retrospective review of patients treated with topical MMC for ocular surface neoplasia, including primary acquired melanosis (PAM), melanoma, corneal-conjunctival intraepithelial neoplasia (CCIN), squamous cell carcinoma (SCC) and sebaceous gland carcinoma (SGC).
  • Data regarding diagnosis, short- and long-term outcomes, and short- and long-term complications, were recorded.
  • Overall, 26% developed recurrent disease at a mean of 13 months post treatment.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Eye Neoplasms / drug therapy. Mitomycin / administration & dosage. Sebaceous Gland Neoplasms / drug therapy

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  • Hazardous Substances Data Bank. MITOMYCIN C .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 20530655.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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99. Berlin AL, Amin SP, Goldberg DJ: Extraocular sebaceous carcinoma treated with Mohs micrographic surgery: report of a case and review of literature. Dermatol Surg; 2008 Feb;34(2):254-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extraocular sebaceous carcinoma treated with Mohs micrographic surgery: report of a case and review of literature.
  • [MeSH-major] Adenocarcinoma, Sebaceous / surgery. Mohs Surgery / methods. Sebaceous Gland Neoplasms / surgery

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  • (PMID = 18093187.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Tanahashi J, Kashima K, Daa T, Yada N, Fujiwara S, Yokoyama S: Merkel cell carcinoma co-existent with sebaceous carcinoma of the eyelid. J Cutan Pathol; 2009 Sep;36(9):983-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Merkel cell carcinoma co-existent with sebaceous carcinoma of the eyelid.
  • Merkel cell carcinoma is occasionally associated with other types of cutaneous malignancies including squamous cell carcinoma, basal cell carcinoma and lentigo maligna.
  • We report a case of Merkel cell carcinoma co-existent with sebaceous carcinoma in the right upper eyelid of a 61-year-old Japanese man.
  • Two nodules were Merkel cell carcinoma and located in the proximal part of the palpebral conjunctiva.
  • The third was sebaceous carcinoma located in the distal transitional zone between the epidermis and the conjunctiva.
  • Metastatic deposits were identified in the regional lymph nodes, which solely consisted of Merkel cell carcinoma without sebaceous carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma, Merkel Cell / pathology. Eyelid Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19017040.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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