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Items 1 to 100 of about 247
1. Rizvi SA, Maheshwari V: Advanced upper eyelid sebaceous gland carcinoma with deep orbital extension. J Surg Case Rep; 2010;2010(1):5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Advanced upper eyelid sebaceous gland carcinoma with deep orbital extension.
  • Sebaceous gland carcinomas (SGC) are highly malignant lid tumors which originate from meibomian glands and rarely from the gland of Zeis, sebaceous gland of caruncle, eyebrows and periocular skin.
  • In many cases correct diagnosis of SGC is delayed because of its ability to masquerade as a variety of other ocular conditions.
  • A differential diagnosis of sebaceous gland carcinoma or preseptal cellulitis was made.
  • A diagnosis of meibomian gland carcinoma was confirmed on histopathology.
  • This is a report of an advanced sebaceous gland carcinoma with deep orbital extension.
  • An early diagnosis and appropriate treatment may decrease the long term morbidity and extend the survival rate of such patients.

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  • [Copyright] © JSCR.
  • (PMID = 24945508.001).
  • [ISSN] 2042-8812
  • [Journal-full-title] Journal of surgical case reports
  • [ISO-abbreviation] J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3649079
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2. Wali UK, Al-Mujaini A: Sebaceous gland carcinoma of the eyelid. Oman J Ophthalmol; 2010 Sep;3(3):117-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous gland carcinoma of the eyelid.
  • Sebaceous gland carcinoma, commonly arises in the periocular area, is an uncommon condition.
  • It represents 1-5.5% of eyelid malignancies and is considered to be the third most common eyelid malignancy after basal cell and squamous cell carcinomas, although few reports placed this tumor as second most common after basal cell carcinoma.
  • A delay in diagnosis, which can be attributed primarily to ability of this tumor to masquerade as more benign conditions, often leads to inappropriate management with increased morbidity and mortality rates.
  • In this study, the authors discuss key elements of the primary disease and therapeutic options available to treat such devastating problem.

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  • (PMID = 21120046.001).
  • [ISSN] 0974-7842
  • [Journal-full-title] Oman journal of ophthalmology
  • [ISO-abbreviation] Oman J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2992157
  • [Keywords] NOTNLM ; Moh’s / nodular / pagetoid / sebaceous gland carcinoma
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3. Maheshwari R, Maheshwari S, Shekde S: Role of fine needle aspiration cytology in diagnosis of eyelid sebaceous carcinoma. Indian J Ophthalmol; 2007 May-Jun;55(3):217-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of fine needle aspiration cytology in diagnosis of eyelid sebaceous carcinoma.
  • Sebaceous carcinoma of the ocular adnexa is a malignant neoplasm which can exhibit aggressive local behavior and can metastasize to regional lymph nodes and distant organs.
  • The neoplasm is known to masquerade as other benign and less malignant lesions, resulting in delay in diagnosis and relative high morbidity and mortality.
  • Subsequently histopathology confirmed the diagnosis of sebaceous gland carcinoma.
  • The article highlights the role of FNAC in early diagnosis and subsequent appropriate surgical management of eyelid sebaceous gland carcinoma to prevent recurrence and metastasis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biopsy, Fine-Needle. Eyelid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged, 80 and over. Early Diagnosis. Female. Humans. Male. Middle Aged

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  • (PMID = 17456941.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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4. Khong JJ, Leibovitch I, Selva D, Dodd T, Muecke J: Sebaceous gland carcinoma of the eyelid presenting as a conjunctival papilloma. Clin Exp Ophthalmol; 2005 Apr;33(2):197-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous gland carcinoma of the eyelid presenting as a conjunctival papilloma.
  • An unusual presentation of sebaceous carcinoma of the eyelid is described in a 96-year-old man who presented with a large papillomatous palpebral conjunctival lesion in the left upper eyelid.
  • Histopathology revealed a sebaceous gland carcinoma with no evidence of pagetoid spread.
  • Although rare, sebaceous gland carcinoma should be considered in the differential diagnosis of a conjunctival papilloma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Conjunctival Neoplasms / pathology. Eyelid Neoplasms / diagnosis. Papilloma / pathology. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Humans. Male

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  • (PMID = 15807833.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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5. Murthy R, Honavar SG, Burman S, Vemuganti GK, Naik MN, Reddy VA: Neoadjuvant chemotherapy in the management of sebaceous gland carcinoma of the eyelid with regional lymph node metastasis. Ophthal Plast Reconstr Surg; 2005 Jul;21(4):307-9
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  • [Title] Neoadjuvant chemotherapy in the management of sebaceous gland carcinoma of the eyelid with regional lymph node metastasis.
  • A 55-year-old Asian Indian woman who had recurrent sebaceous gland carcinoma of the left lower eyelid with orbital extension and regional lymph node metastasis was treated with neoadjuvant chemotherapy, using a combination of carboplatin and 5-fluorouracil.
  • The patient had limited morbidity and was free of local, regional, and systemic disease at 26 months of follow-up.
  • [MeSH-major] Adenocarcinoma, Sebaceous / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Eyelid Neoplasms / drug therapy. Orbital Neoplasms / drug therapy. Sebaceous Gland Neoplasms / drug therapy

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  • (PMID = 16052148.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; U3P01618RT / Fluorouracil
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6. Swick JM, Lang PG Jr: Sebaceous gland carcinoma of the right flank. South Med J; 2009 Mar;102(3):312-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous gland carcinoma of the right flank.
  • Extraocular sebaceous gland carcinoma is a rare cutaneous malignancy which sometimes can grow rapidly.
  • There is no proven effective treatment for metastatic disease, but the tumor can be successfully treated by surgery if diagnosed early.
  • We report an 83-year-old gentleman with a rapidly growing sebaceous gland carcinoma of the right flank which was initially misdiagnosed as a vascular malformation.
  • By the time he was referred, he had widespread metastatic disease and was a candidate for palliative radiation only.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Adenocarcinoma, Sebaceous / pathology. Diagnostic Errors. Sebaceous Gland Neoplasms / diagnosis. Sebaceous Gland Neoplasms / pathology. Vascular Malformations / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Male. Neoplasm Metastasis. Palliative Care

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  • (PMID = 19204605.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Newman BD, Maher JF, Subauste JS, Uwaifo GI, Bigler SA, Koch CA: Clustering of sebaceous gland carcinoma, papillary thyroid carcinoma and breast cancer in a woman as a new cancer susceptibility disorder: a case report. J Med Case Rep; 2009;3:6905
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clustering of sebaceous gland carcinoma, papillary thyroid carcinoma and breast cancer in a woman as a new cancer susceptibility disorder: a case report.
  • INTRODUCTION: Multiple distinct tumors arising in a single individual or within members of a family raise the suspicion of a genetic susceptibility disorder.
  • CASE PRESENTATION: We present the case of a 52-year-old Caucasian woman diagnosed with sebaceous gland carcinoma of the eyelid, followed several years later with subsequent diagnoses of breast cancer and papillary carcinoma of the thyroid.
  • Although the patient was also exposed to radiation from a pipe used in the oil field industry, the constellation of neoplasms in this patient suggests the manifestation of a known hereditary susceptibility cancer syndrome.
  • CONCLUSION: We propose that our patient's clustering of neoplasms either represents a novel cancer susceptibility disorder, of which sebaceous gland carcinoma is a characteristic feature, or is a variant of the Muir-Torre syndrome.

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  • (PMID = 19830129.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2759639
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8. Park SJ, Wee WR, Lee JH, Kim MK: Primary sebaceous carcinoma of the corneaoscleral limbus with pagetoid recurrence. Korean J Ophthalmol; 2009 Jun;23(2):104-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary sebaceous carcinoma of the corneaoscleral limbus with pagetoid recurrence.
  • We report a sebaceous carcinoma confined to the corneoscleral limbus without involvement of the eyelid.
  • Histopathologic examination revealed a sebaceous carcinoma.
  • This report shows that the ulcerative mass which is confined to only the corneoscleral limbus may be a sebaceous carcinoma even without eyelid involvement.
  • Topical mitomycin C may be effective for treating pagetoid spread of sebaceous carcinoma of limbal origin.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eye Neoplasms / pathology. Limbus Corneae / pathology. Neoplasm Recurrence, Local. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Biological Dressings. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Ophthalmologic Surgical Procedures / methods

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  • (PMID = 19568359.001).
  • [ISSN] 2092-9382
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2694285
  • [Keywords] NOTNLM ; Conjunctiva / Limbus / Mitomycin C / Pagetoid recurrence / Sebaceous carcinoma
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9. Detorakis ET, Ioannakis K, Giatromanolaki A, Sivridis E, Drakonaki E, Kozobolis VP: Selective removal of sebaceous gland carcinoma of the lower eyelid with orbital infiltration. Ophthalmic Surg Lasers Imaging; 2007 Sep-Oct;38(5):413-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selective removal of sebaceous gland carcinoma of the lower eyelid with orbital infiltration.
  • An incisional biopsy was significant for sebaceous gland carcinoma, whereas magnetic resonance imaging revealed infiltration of the ipsilateral orbit, including the medial and lower rectus muscles.
  • Preoperative orbital imaging is mandatory in cases of sebaceous gland carcinoma because it can reveal clinically silent orbital invasion.
  • [MeSH-major] Carcinoma / surgery. Eyelid Neoplasms / surgery. Ophthalmologic Surgical Procedures. Orbit / surgery. Sebaceous Gland Neoplasms / surgery

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  • (PMID = 17955850.001).
  • [ISSN] 1542-8877
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Li B, Li N, Cheng G, Sun X, Xu X, Shi J, Li L, Chen C: Correlation of the expression of telomerase RNA with risk factors for recurrence of sebaceous gland carcinoma. Graefes Arch Clin Exp Ophthalmol; 2006 Apr;244(4):480-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation of the expression of telomerase RNA with risk factors for recurrence of sebaceous gland carcinoma.
  • AIMS: To investigate the expression of human telomerase gene RNA (hTR) and human telomerase reverse transcriptase (hTRT) in eyelid sebaceous gland carcinoma and to evaluate risk factors for sebaceous carcinoma recurrence.
  • METHODS: The expression patterns of hTR and hTRT were detected by in situ hybridization (ISH) in paraffin-embedded samples of 55 eyelid sebaceous gland carcinoma, 12 chalazia, and four sebaceous adenoma.
  • The proliferation index (PI) of sebaceous gland carcinoma was determined by Ki-67 immunolabeling and the results were compared with the expression of hTR and hTRT.
  • Several factors for recurrence of sebaceous gland carcinoma were evaluated by statistical analysis.
  • RESULTS: Expression of hTR and hTRT was present mainly in the sebaceous gland carcinoma tissues and not in adjacent tissues of carcinoma, chalazia, and sebaceous adenoma.
  • The prevalence of hTR, hTRT, and Ki-67 expression in 55 sebaceous carcinoma samples were 84.45%, 58.1%, and 78.18%, respectively. hTR expression was highly associated with the degree of carcinoma differentiation (P<0.001) and hTRT expression was correlated with the proliferation index as determined by Ki-67 staining (P<0.005).
  • There was a correlation between the recurrence of sebaceous gland carcinoma and the patient's onset age (OR=0.914, P<0.05), as well as the time to first treatment (OR=1.163, P<0.01).
  • CONCLUSIONS: Telomerase may play an important role in the carcinogenesis of sebaceous gland carcinoma, and expression of hTR and hTRT combined with other features of sebaceous gland carcinoma may be helpful for the diagnosis and evaluation of clinical prognosis.
  • Risk factors for recurrence of sebaceous gland carcinoma are patients' onset age and the time to first treatment.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Eyelid Neoplasms / metabolism. Neoplasm Recurrence, Local / metabolism. RNA, Untranslated / metabolism. Sebaceous Gland Neoplasms / metabolism. Telomerase / metabolism

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  • (PMID = 16133023.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / RNA, Long Noncoding; 0 / RNA, Untranslated; 0 / telomerase RNA; 63231-63-0 / RNA; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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11. Rudkin AK, Muecke JS: Mitomycin-C as adjuvant therapy in the treatment of sebaceous gland carcinoma in high-risk locations. Clin Exp Ophthalmol; 2009 May;37(4):352-6
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  • [Title] Mitomycin-C as adjuvant therapy in the treatment of sebaceous gland carcinoma in high-risk locations.
  • PURPOSE: To report on the use of Mitomycin-C as adjuvant therapy to excision and cryotherapy in patients with sebaceous gland carcinoma (SGC) in high-risk locations.
  • RESULTS: No patients had evidence of local recurrence or systemic disease.
  • [MeSH-major] Adenocarcinoma, Sebaceous / therapy. Antibiotics, Antineoplastic / therapeutic use. Conjunctival Neoplasms / therapy. Mitomycin / therapeutic use. Sebaceous Gland Neoplasms / therapy

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  • (PMID = 19594560.001).
  • [ISSN] 1442-9071
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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12. Shields JA, Shields CL, Marr BP, Eagle RC Jr: Sebaceous carcinoma of the caruncle. Cornea; 2006 Aug;25(7):858-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the caruncle.
  • PURPOSE: To report a case of sebaceous carcinoma of the caruncle.
  • Incisional biopsy elsewhere was interpreted histopathologically as invasive squamous cell carcinoma.
  • On the basis of the clinical findings, however, we suspected sebaceous carcinoma.
  • RESULTS: Histopathological examination disclosed infiltration of the caruncular stroma by lobules of a malignant neoplasm that had prominent cytoplasmic vacuoles, typical of sebaceous carcinoma.
  • CONCLUSION: Although it is best known to arise in the meibomian glands of the tarsus, sebaceous carcinoma can rarely arise in the caruncle and can be misinterpreted histopathologically as squamous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 17068467.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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13. Gil da Costa RM, Rema A, Payo-Puente P, Gärtner F: Immunohistochemical characterization of a sebaceous gland carcinoma in a gerbil (Meriones unguiculatus). J Comp Pathol; 2007 Aug-Oct;137(2-3):130-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical characterization of a sebaceous gland carcinoma in a gerbil (Meriones unguiculatus).
  • Sebaceous gland carcinoma is a common tumour in male gerbils but, to date, no information is available on its immunohistochemical properties.
  • The differences observed in p53 and c-erbB-2 immunolabelling between carcinomatous and hyperplastic areas suggest that p53 mutations and amplification of c-erbB-2 may play a significant role in the oncogenesis of sebaceous gland carcinoma in the gerbil.
  • [MeSH-major] Gerbillinae. Receptor, ErbB-2 / metabolism. Sebaceous Gland Neoplasms / veterinary. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17645891.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Keratin-14; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, ErbB-2
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14. Izumi M, Mukai K, Nagai T, Matsubayashi J, Iwaya K, Chiu CS, Goto H: Sebaceous carcinoma of the eyelids: thirty cases from Japan. Pathol Int; 2008 Aug;58(8):483-8
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  • [Title] Sebaceous carcinoma of the eyelids: thirty cases from Japan.
  • Sebaceous carcinoma of the eyelids is rare in Western countries but not uncommon in Asian countries.
  • Diagnosis is difficult both clinically and histologically.
  • Thirty cases of sebaceous carcinoma of the eyelids treated at Tokyo Medical University Hospital were reviewed to elicit characteristic features of pathological findings.
  • Sebaceous duct differentiation, namely holocrine secretion indicating a specific type of coagulation necrosis maintaining a cellular framework or maintaining a bubbly cytoplasm associated with nuclear debris in the periphery, was seen in 24 cases (80%).
  • In conclusion, to detect sebaceous differentiation in sebaceous carcinoma, it would be helpful to focus on holocrine secretion, squamous differentiation and foamy macrophage infiltration, and to utilize immunohistochemistry involving anti-perilipin and anti-adipophilin stain.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology

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  • (PMID = 18705767.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Membrane Proteins; 0 / Mucin-1; 0 / Phosphoproteins; 0 / perilipin 1; 0 / perilipin 2
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15. Keskinaslan I, Pedroli GL, Piffaretti JM, Meyer P, Kunz C, Haefliger IO: Eyelid sebaceous gland carcinoma in a young Caucasian man. Klin Monbl Augenheilkd; 2008 May;225(5):422-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eyelid sebaceous gland carcinoma in a young Caucasian man.
  • BACKGROUND: Eyelid sebaceous gland carcinoma is rarely observed in young Caucasian men.
  • Cytology of the fluid in the cyst and histology of the lesion were compatible with a sebaceous cell carcinoma.
  • THERAPY AND OUTCOME: According to current clinical practice and experience, to increase the chance of survival of the patient, an orbital exenteration was conducted to remove the sebaceous cell carcinoma in total.
  • CONCLUSIONS: Although rare, one should be aware that an eyelid sebaceous cell carcinoma can occur in a young Caucasian man and this diagnosis should be evoked in case of a recurrent chalazion.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / surgery. Eyelid Neoplasms / diagnosis. Eyelid Neoplasms / surgery. Sebaceous Gland Neoplasms / diagnosis. Sebaceous Gland Neoplasms / surgery

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  • (PMID = 18454385.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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16. Oshiro H, Iwai T, Hirota M, Mitsudo K, Tohnai I, Minamimoto R, Omura-Minamisawa M, Nagashima Y, Yamanaka S, Fukui T, Kanazawa M, Sagawa H, Mita K, Nakayama T, Inayama Y: Primary sebaceous carcinoma of the tongue. Med Mol Morphol; 2010 Dec;43(4):246-52
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  • [Title] Primary sebaceous carcinoma of the tongue.
  • Sebaceous carcinoma is the rarest type of oral malignancies.
  • We report a case of primary sebaceous carcinoma of the tongue.
  • Our case demonstrates that superselective intraarterial chemotherapy combined with concurrent radiotherapy can be effective in treating the primary lesion of patients with a sebaceous carcinoma of the tongue.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Tongue Neoplasms / pathology

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  • [Cites] Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1090-100 [18411003.001]
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  • (PMID = 21267703.001).
  • [ISSN] 1860-1499
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Mebazaa A, Boussofara L, Trabelsi A, Denguezli M, Sriha B, Belajouza C, Nouira R: Undifferentiated sebaceous carcinoma: an unusual childhood cancer. Pediatr Dermatol; 2007 Sep-Oct;24(5):501-4
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  • [Title] Undifferentiated sebaceous carcinoma: an unusual childhood cancer.
  • Sebaceous carcinoma is an aggressive, adnexal, rare malignant tumor that may arise in ocular or extra-ocular sites.
  • Extraorbital sebaceous carcinoma is exceptional in childhood.
  • We report a 12-year-old boy with an ocular sebaceous carcinoma who was first seen with an asymptomatic firm, cutaneous nodule on the right eyebrow.
  • Histologically, it was an undifferentiated sebaceous carcinoma.
  • He was alive and free from disease at a follow-up of 34 months.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyebrows / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 17958796.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Scuderi S, Giaccone M, D'Errico E, Maorenzic MA, Fontanellaa M, Castellano I, Zanon C, Gaetini AM: Aggressive sebaceous carcinoma of the head. Chir Ital; 2009 May-Jun;61(3):401-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive sebaceous carcinoma of the head.
  • Cutaneous sebaceous carcinoma (SC) is a rare malignancy deriving from the adnexal epithelium of the sebaceous glands.
  • Extraocular SC is reported to be less aggressive than orbital sebaceous carcinoma and rarely metastasizes.
  • We report a case of sebaceous carcinoma of the scalp, characterised by highly aggressive behaviour and huge invasion of the intracranial space.
  • The patient was a 79-year-old woman who developed an infiltrating sebaceous carcinoma followed by lymph-node metastases shortly after excision of the primary lesion, resulting in death.
  • In this case, aggressive biological behaviour was observed in a carcinoma arising in an extraorbital area, although it has traditionally been considered a less aggressive neoplasm.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Head and Neck Neoplasms / pathology. Scalp / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 19694247.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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19. Rigas PK, Kase S, Rao NA: Expression of alpha-crystallins in human sebaceous carcinoma of the eyelid. Eur J Ophthalmol; 2009 Sep-Oct;19(5):702-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of alpha-crystallins in human sebaceous carcinoma of the eyelid.
  • This study used immunohistochemistry to examine the expression of alphaA-crystallin and alphaB-crystallin in human sebaceous carcinoma tissues.
  • METHODS: Nine patients with sebaceous carcinoma of the eyelid underwent excision of the eyelid or orbital exenteration.
  • RESULTS: In the noncancerous eyelid, crystallins were weakly and homogeneously expressed in the Meibomian gland lobules.
  • In eyelids with sebaceous carcinoma, alphaA-crystallin and alphaB-crystallin were highly expressed in 4 cases, where the cytoplasmic immunoreactivity was heterogeneously detected in the tumor cells.
  • A statistically significant correlation was observed between expression levels of alphaA-crystallin and alphaB-crystallin in sebaceous carcinomas (p=0.012).
  • All sebaceous carcinoma tissues contained mitotic tumor cells, which showed predominantly perinuclear immunoreactivity of alphaB-crystallin.
  • CONCLUSIONS: Crystallins are expressed in human sebaceous carcinomas including mitotic cells.

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  • (PMID = 19787585.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY017347-03; United States / NEI NIH HHS / EY / P30 EY003040-30; United States / NEI NIH HHS / EY / EY017347-03; United States / NEI NIH HHS / EY / R01 EY017347; United States / NEI NIH HHS / EY / EY015714; United States / NEI NIH HHS / EY / P30 EY003040; United States / NEI NIH HHS / EY / EY03040; United States / NEI NIH HHS / EY / R01 EY015714
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / alpha-Crystallin A Chain; 0 / alpha-Crystallin B Chain
  • [Other-IDs] NLM/ NIHMS218754; NLM/ PMC3062472
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20. Pereira PR, Odashiro AN, Rodrigues-Reyes AA, Correa ZM, de Souza Filho JP, Burnier MN Jr: Histopathological review of sebaceous carcinoma of the eyelid. J Cutan Pathol; 2005 Aug;32(7):496-501

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathological review of sebaceous carcinoma of the eyelid.
  • BACKGROUND: Sebaceous carcinoma of the eyelid can clinically mimic benign conditions, such as recurrent chalazion and inflammation and histopathologically squamous cell and basal cell carcinoma (BCC).
  • This retrospective study was undertaken as an attempt to improve the characterization and consequently the diagnosis of these tumors.
  • METHODS: Retrospective analysis was performed on eyelid specimens diagnosed as sebaceous carcinoma retrieved from Henry C.
  • Of these, 75% had features similar to squamous cell carcinoma (SqCC), some with dyskeratosis (30%) and 7% resembled BCC.
  • Superficial spread resembling Bowen-like disease was observed in 33% of the cases, pagetoid features in 33% and comedocarcinoma in 31.8%.
  • CONCLUSION: Sebaceous carcinoma presented as a poorly differentiated lesion in most cases of this series, which suggests a possibility of misdiagnosis because of its similarities to SqCC.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Chalazion / diagnosis. Diagnosis, Differential. Humans. Retrospective Studies. Single-Blind Method. Vacuoles / pathology

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  • (PMID = 16008694.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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21. Chang SC, Liao JW, Wong ML, Lai YS, Liu CI: Mammary carcinoma with sebaceous differentiation in a dog. Vet Pathol; 2007 Jul;44(4):525-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammary carcinoma with sebaceous differentiation in a dog.
  • This report describes an invasive mammary carcinoma with a rare distinctive feature characterized by sebaceous differentiation of tumor cells.
  • The patient had two masses in the left fifth mammary gland.
  • Microscopically, the tumors were composed of two distinctive neoplastic components, intraductal papillary adenocarcinoma and sebaceous carcinoma.
  • The regions of sebaceous tumor were clumped separately, contained well-developed sebaceous cells and keratinized epithelial cells, and were surrounded by few to several layers of basaloid cells.
  • The cells with abundant foamy cytoplasm that resembled sebaceous cells were also found within the intraductal papillary-like nests of mammary carcinoma, providing evidence of sebaceous metaplasia.
  • Sebaceous differentiation in a mammary gland tumor is possible, because skin appendages and ductal apparatus of the mammary gland share a common anlagen.
  • [MeSH-major] Mammary Neoplasms, Animal / pathology. Sebaceous Glands / pathology

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  • (PMID = 17606516.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Cibull TL, Thomas AB, Badve S, Billings SD: Sebaceous carcinoma of the nipple. J Cutan Pathol; 2008 Jun;35(6):608-10
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  • [Title] Sebaceous carcinoma of the nipple.
  • Sebaceous carcinoma (SC) is an uncommon neoplasm that usually presents as an ocular or extraocular cutaneous lesion of the head and neck.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Breast Neoplasms / pathology. Nipples / pathology
  • [MeSH-minor] Aged, 80 and over. Disease-Free Survival. Female. Humans. Treatment Outcome

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  • (PMID = 18466364.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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23. Xu X, Jia R, Zhou Y, Song X, Fan X: Investigation of vasculogenic mimicry in sebaceous carcinoma of the eyelid. Acta Ophthalmol; 2010 Aug;88(5):e160-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Investigation of vasculogenic mimicry in sebaceous carcinoma of the eyelid.
  • The purpose of this study was to investigate whether sebaceous carcinomas of the eyelid exhibit VM and to determine whether these fluid-conducting patterns are associated with clinicopathologic features, the number of microvessels and the levels of endothelial growth factor (VEGF) and matrix metalloprotease-2 (MMP-2) in tumours.
  • METHODS: Forty paraffin-embedded samples of sebaceous carcinoma of the eyelid were collected, along with complete clinical and pathologic data for all the cases.
  • CONCLUSIONS: Vasculogenic mimicry is present in sebaceous carcinoma of the eyelid making it an unfavourable prognosis sign.
  • MMP-2 is associated with VM formation in sebaceous carcinoma of the eyelid.
  • [MeSH-major] Adenocarcinoma, Sebaceous / blood supply. Eyelid Neoplasms / blood supply. Matrix Metalloproteinase 2 / metabolism. Neovascularization, Pathologic / diagnosis. Sebaceous Gland Neoplasms / blood supply. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 20553231.001).
  • [ISSN] 1755-3768
  • [Journal-full-title] Acta ophthalmologica
  • [ISO-abbreviation] Acta Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; EC 3.4.24.24 / Matrix Metalloproteinase 2
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24. Kinkor Z, Meciarová I, Havlícek F: [Primary sebaceous carcinoma of the breast; three casuistic reports]. Ceska Gynekol; 2010 Feb;75(1):50-3
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  • [Title] [Primary sebaceous carcinoma of the breast; three casuistic reports].
  • [Transliterated title] Primární sebaceózní karcinom prsu - klinicko-morfologická analogie kozní adnexální léze? Popis trí prípadů.
  • OBJECTIVE: Presentation of three cases of primary sebaceous carcinoma of the breast particularly focusing on the clinical, biological and molecular genetic aspects regarding their possible pathogenetic relationship to the Muir-Torre and Lynch syndrome.
  • Reviewed are basic principles of miscosatellite instability and dysregulations of mismatch repair genes by these inherited tumorous syndromes especially looking for morphologic and fenotypic parallels between sebaceous carcinomas of the breast and their cutaneous counterparts.
  • RESULTS: In three women aged 51 to 69 was diagnosed primary sebaceous carcinoma of the breast with maximum dimension ranged from 13 to 41 mm.
  • Follow-up available in two women, both without regional metastasis, revealed no local or distant progression of the disease.
  • The histology consisted of conventional G1-2 invasive duct carcinoma in all cases and sebaceous differentiation represented 10-40% of all neoplastic population.
  • Familial tumorous stigmas were not evident and subsequent close clinical monitoring in two of the patients tracked down no intern malignancy, including cutaneous sebaceous lesion.


25. Alawi F, Siddiqui A: Sebaceous carcinoma of the oral mucosa: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Jan;99(1):79-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the oral mucosa: case report and review of the literature.
  • However, primary malignant sebaceous tumors of the oral mucosa are exceedingly rare.
  • To our knowledge, only 5 examples of intraoral sebaceous carcinoma have been reported in the literature.
  • This report describes a primary sebaceous carcinoma of the labial mucosa that arose in an area containing numerous Fordyce granules.
  • A brief review of the clinical and histopathologic features of sebaceous carcinoma is also presented.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Lip Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Choristoma / pathology. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Mouth Diseases / pathology. Mouth Mucosa / pathology. Mucin-1 / analysis. Receptors, Androgen / analysis. Sebaceous Glands / pathology. Sweat Glands / pathology

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  • (PMID = 15599352.001).
  • [ISSN] 1079-2104
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucin-1; 0 / Receptors, Androgen
  • [Number-of-references] 42
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26. Koreen IV, Flint A, Nelson CC, Frueh BR, Elner VM: Nondiagnostic conjunctival map biopsies for sebaceous carcinoma. Arch Ophthalmol; 2009 Aug;127(8):961-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nondiagnostic conjunctival map biopsies for sebaceous carcinoma.
  • OBJECTIVE: To compare the prevalence of nondiagnostic conjunctival map biopsies in patients with extensive pagetoid sebaceous carcinoma (defined as involvement of 3 or 4 quadrants of the ocular surface) and in patients without extensive pagetoid tumor (defined as involvement of 1 or 2 quadrants of the ocular surface).
  • METHODS: Retrospective medical record and pathologic specimen review of 20 patients treated for sebaceous carcinoma at a tertiary care center.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma in Situ / pathology. Conjunctival Neoplasms / pathology

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  • (PMID = 19667331.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30 EY007003; United States / NEI NIH HHS / EY / P30 EY007003
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS327247; NLM/ PMC3208231
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27. Shields JA, Demirci H, Marr BP, Eagle RC Jr, Stefanyszyn M, Shields CL: Conjunctival epithelial involvement by eyelid sebaceous carcinoma. The 2003 J. Howard Stokes lecture. Ophthal Plast Reconstr Surg; 2005 Mar;21(2):92-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjunctival epithelial involvement by eyelid sebaceous carcinoma. The 2003 J. Howard Stokes lecture.
  • PURPOSE: To determine incidence and distribution of conjunctival epithelial involvement by eyelid sebaceous carcinoma and to make recommendations regarding its management.
  • METHODS: The medical records were reviewed retrospectively on patients with histopathologically confirmed sebaceous carcinoma of the eyelids managed at the Oncology Service at Wills Eye Hospital.
  • Based on these findings and personal surgical experience, recommendations are made regarding management of eyelid sebaceous carcinoma with involvement of the conjunctival epithelium.
  • RESULTS: Of 60 patients with sebaceous carcinoma, epithelial involvement of the conjunctiva was identified in 28 (47%).
  • CONCLUSIONS: Eyelid sebaceous carcinoma was found to exhibit epithelial involvement of the conjunctiva in 47% of cases, predominantly in the superior tarsal and fornical conjunctiva and less often in the inferior tarsal conjunctiva, caruncle, and cornea.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma in Situ / pathology. Conjunctival Neoplasms / pathology. Eyelid Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 15778660.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Lectures; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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28. Kim HJ, Kim YB, Park JW, Oh WS, Kim EO, Lim BY, Kim DY: Recurrent sebaceous carcinoma in an African hedgehog (Atelerix albiventris). J Vet Med Sci; 2010 Jul;72(7):947-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent sebaceous carcinoma in an African hedgehog (Atelerix albiventris).
  • Based on these findings, a diagnosis of sebaceous carcinoma was made.
  • This is the first report of a sebaceous carcinoma in an African hedgehog.

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  • (PMID = 20215722.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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29. Tanahashi J, Kashima K, Daa T, Yada N, Fujiwara S, Yokoyama S: Merkel cell carcinoma co-existent with sebaceous carcinoma of the eyelid. J Cutan Pathol; 2009 Sep;36(9):983-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Merkel cell carcinoma co-existent with sebaceous carcinoma of the eyelid.
  • Merkel cell carcinoma is occasionally associated with other types of cutaneous malignancies including squamous cell carcinoma, basal cell carcinoma and lentigo maligna.
  • We report a case of Merkel cell carcinoma co-existent with sebaceous carcinoma in the right upper eyelid of a 61-year-old Japanese man.
  • Two nodules were Merkel cell carcinoma and located in the proximal part of the palpebral conjunctiva.
  • The third was sebaceous carcinoma located in the distal transitional zone between the epidermis and the conjunctiva.
  • Metastatic deposits were identified in the regional lymph nodes, which solely consisted of Merkel cell carcinoma without sebaceous carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma, Merkel Cell / pathology. Eyelid Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19017040.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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30. Saito A, Tsutsumida A, Furukawa H, Saito N, Yamamoto Y: Sebaceous carcinoma of the eyelids: a review of 21 cases. J Plast Reconstr Aesthet Surg; 2008 Nov;61(11):1328-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the eyelids: a review of 21 cases.
  • BACKGROUND: Sebaceous carcinoma is a malignant neoplasm that arises from the sebaceous glands and occurs most often in the eyelids.
  • In this article, we studied the management and outcomes of sebaceous carcinoma using the T classification.
  • METHODS: We report our experience of sebaceous carcinoma of the eyelids in 21 patients between December 1979 and December 2003.
  • We employed the method of T classification and assessed the management and clinical outcomes in patients with sebaceous carcinoma of the eyelids.
  • Therefore, the T classification alone may be an important factor in determining the prognosis for sebaceous carcinoma of the eyelids.
  • [MeSH-major] Adenocarcinoma, Sebaceous / surgery. Blepharoplasty / methods. Eyelid Neoplasms / surgery. Sebaceous Gland Neoplasms / surgery

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  • (PMID = 17974515.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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31. Ornellas AA, Frota R, Lopes da Silva LF, Dauster B, Quirino R, de Santos Schwindt AB, Pereira MR: Sebaceous carcinoma of the penis. Urol Int; 2009;82(4):477-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the penis.
  • Sebaceous carcinoma is a very aggressive malignant tumor, derived from the adnexal epithelium of sebaceous glands.
  • Extraocular sebaceous carcinoma is a very uncommon neoplasm usually localized on the head and neck.
  • To our knowledge, there are only 2 previously reported cases of sebaceous carcinoma on the penis.
  • We report the clinicopathologic data on 3 additional cases of sebaceous carcinoma arising in the penis.
  • [MeSH-major] Carcinoma. Penile Neoplasms

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19506419.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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32. Shields JA, Demirci H, Marr BP, Eagle RC Jr, Shields CL: Sebaceous carcinoma of the ocular region: a review. Surv Ophthalmol; 2005 Mar-Apr;50(2):103-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the ocular region: a review.
  • Sebaceous carcinoma of the ocular region is a malignant neoplasm that is being recognized more frequently and managed by innovative techniques of local resection, cryotherapy, topical chemotherapy, and radiotherapy, resulting in improved visual and systemic prognosis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 15749305.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 168
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33. Warnecke KK, Sieg P: [Sebaceous carcinoma of the eyelids--case reports and review of the literature]. Klin Monbl Augenheilkd; 2006 Sep;223(9):771-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sebaceous carcinoma of the eyelids--case reports and review of the literature].
  • BACKGROUND: Sebaceous carcinomas are among the most rarely found skin tumours (0.2 - 4.6 %).
  • The cytological origins are foremost the Meibomian and the glands of Zeis.
  • CASE REPORTS: We report on two female patients suffering from sebaceous carcinoma of the upper and lower lid.
  • The time span from initial treatment up to definite diagnosis and treatment was one year.
  • In the second case a lymph node metastasis of the parotid gland was found seven years after initial therapy and surgically removed followed by a complete parotidectomy and neck dissection.
  • DISCUSSION: As the sebaceous carcinomas are difficult to differentiate from other kinds of benign and malignant eyelid diseases, a considerable delay between the initial examination and final diagnosis is not uncommon.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Eyelid Neoplasms / surgery. Skin Neoplasms / pathology

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  • (PMID = 16986089.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 28
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34. Burns SJ, Foss AJ, Butler TK: Outcome of periocular sebaceous gland carcinoma. Ophthal Plast Reconstr Surg; 2005 Sep;21(5):353-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome of periocular sebaceous gland carcinoma.
  • PURPOSE: To determine the long-term outcome of periocular sebaceous gland carcinoma and factors predictive of tumor recurrence.
  • METHODS: A retrospective case note review of all patients with periocular sebaceous gland carcinoma treated at the Queen's Medical Centre, Nottingham, United Kingdom, between 1992 and 1999.
  • CONCLUSIONS: In our unit, the best prognostic factor for sebaceous gland carcinoma is a histologic report confirming complete excision of the tumor, whatever the tumor size or pattern of spread identified.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 16234697.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Buitrago W, Joseph AK: Sebaceous carcinoma: the great masquerader: emgerging concepts in diagnosis and treatment. Dermatol Ther; 2008 Nov-Dec;21(6):459-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma: the great masquerader: emgerging concepts in diagnosis and treatment.
  • Sebaceous carcinoma (SC) is a rare tumor with a high rate of local recurrence and metastasis to lymph nodes and organs.
  • It frequently masquerades as inflammatory conditions or as other tumors leading to delay in diagnosis, inappropriate treatment and increased morbidity and mortality.
  • Sebaceous carcinoma is associated with Muir-Torre syndrome, a genetic condition presenting with sebaceous skin tumors associated with internal malignancy.
  • Greater awareness and understanding of SC and its behavior has led to earlier diagnosis and appropriate treatment.
  • [MeSH-major] Adenocarcinoma, Sebaceous / therapy. Eye Neoplasms / therapy. Sebaceous Gland Neoplasms / therapy

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  • (PMID = 19076624.001).
  • [ISSN] 1529-8019
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 74
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36. Waseem M, Humayun S, Ayaz B: Sebaceous carcinoma of upper eyelid. J Coll Physicians Surg Pak; 2010 Jul;20(7):487-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of upper eyelid.
  • Histopathology report of the tissue revealed it to be the palpebral sebaceous carcinoma, while lymph node showed reactive hyperplasia.
  • [MeSH-major] Eyelid Neoplasms / surgery. Sebaceous Gland Neoplasms / surgery

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  • (PMID = 20642955.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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37. Rath S, Honavar SG, Reddy VA, Naik MN, Vemuganti GK, Murthy R: Sebaceous carcinoma of the eyelid metastasizing to the lacrimal sac after 5 years. Orbit; 2009;28(5):309-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the eyelid metastasizing to the lacrimal sac after 5 years.
  • Eyelid sebaceous carcinoma metastasizing to lacrimal sac is rare.
  • Histopathology confirmed it to be sebaceous carcinoma with uninvolved margins.
  • Repeat excision biopsy and conjunctival map biopsy confirmed recurrent sebaceous carcinoma of the lacrimal sac.
  • [MeSH-major] Adenocarcinoma, Sebaceous / surgery. Eyelid Neoplasms / surgery. Neoplasm Recurrence, Local / surgery

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  • (PMID = 19874127.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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38. Dowd MB, Kumar RJ, Sharma R, Murali R: Diagnosis and management of sebaceous carcinoma: an Australian experience. ANZ J Surg; 2008 Mar;78(3):158-63

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and management of sebaceous carcinoma: an Australian experience.
  • BACKGROUND: Cutaneous sebaceous carcinoma (SC) is a rare malignancy derived from adnexal epithelium of sebaceous glands.
  • METHODS: A retrospective review was undertaken of the cases from the Institute of Clinical Pathology and Medical Research using their histopathology database for patients with a diagnosis of SC.
  • CONCLUSION: Sebaceous carcinoma is a rare tumour.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Adenocarcinoma, Sebaceous / therapy. Neoplasm Recurrence, Local / pathology. Sebaceous Gland Neoplasms / pathology. Sebaceous Gland Neoplasms / therapy

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  • [CommentIn] ANZ J Surg. 2009 Apr;79(4):306-7 [19432724.001]
  • (PMID = 18269479.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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39. Wang H, Yao J, Solomon M, Axiotis CA: Sebaceous carcinoma of the oral cavity: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Aug;110(2):e37-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the oral cavity: a case report and review of the literature.
  • We report the clinical and pathologic features of an intraoral sebaceous carcinoma and review the literature.
  • The intraoral buccal mucosal tumor from a 50-year-old man was a poorly differentiated carcinoma with sebaceous differentiation and expression of androgen receptor.
  • Fordyce granules and a minor salivary gland with a duct were identified in vicinity to the tumor.
  • We discuss the differential diagnosis and histogenesis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Mouth Neoplasms / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20659693.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Androgen
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40. Gallego-Pinazo R, España Gregori E, Aviñó Martínez J, Salom Alonso L, Tormo Micó A, Villanueva Martí R, Díaz-Llopis M: [Multidisciplinary management of an anaplastic sebaceous carcinoma of the eyelid in a 40-year-old woman]. Arch Soc Esp Oftalmol; 2010 Feb;85(2):76-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multidisciplinary management of an anaplastic sebaceous carcinoma of the eyelid in a 40-year-old woman].
  • [Transliterated title] Abordaje multidisciplinar de un carcinoma sebáceo anaplásico palpebral en una paciente de 40 años.
  • The extemporaneous biopsy was reported as sebaceous carcinoma.
  • DISCUSSION: The precocity in diagnosing sebaceous carcinomas of the eyelids is the main prognostic factor.
  • The reconstruction in cases with need of complete eyelid exeresis is feasible by means of a palate mucosa graft.
  • [MeSH-major] Adenocarcinoma, Sebaceous

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  • (PMID = 20566179.001).
  • [ISSN] 1989-7286
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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41. Murakami A, Kawachi K, Sasaki T, Ishikawa T, Nagashima Y, Nozawa A: Sebaceous carcinoma of the breast. Pathol Int; 2009 Mar;59(3):188-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the breast.
  • Sebaceous carcinoma (SC) of the breast is a rare malignant tumor and only nine cases, including the present one, have been reported in the English-language literature.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Breast Neoplasms / pathology. Receptors, Androgen / metabolism. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 19261098.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Receptors, Androgen
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42. Venizelos ID, Tatsiou ZA, Roussos D, Karagiannis V: A case of sebaceous carcinoma arising within a benign ovarian cystic teratoma. Onkologie; 2009 Jun;32(6):353-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of sebaceous carcinoma arising within a benign ovarian cystic teratoma.
  • Malignant change in a component of a mature ovarian teratoma is rare, occurring in less than 2% of cases, with squamous cell carcinoma corresponding to 80% of such neoplasms.
  • Pure sebaceous carcinoma is exceedingly rare, with only 6 reported cases thus far.
  • Histological examination of the tumor showed features of a well-differentiated sebaceous carcinoma arising within a mature cystic teratoma.
  • Differential diagnosis with other malignant neoplasms arising in mature cystic teratomas is exceedingly important for treatment and prognosis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Neoplasms, Multiple Primary / diagnosis. Ovarian Cysts / diagnosis. Ovarian Neoplasms / diagnosis. Teratoma / diagnosis

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19521124.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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43. Hisaoka M, Takamatsu Y, Hirano Y, Maeda H, Hamada T: Sebaceous carcinoma of the breast: case report and review of the literature. Virchows Arch; 2006 Oct;449(4):484-8
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  • [Title] Sebaceous carcinoma of the breast: case report and review of the literature.
  • Sebaceous differentiation has been described in only limited examples of benign and malignant epithelial lesions of the breast.
  • We report a rare case of mammary sebaceous carcinoma to further delineate its morphologic features.
  • Microscopically, the tumor, arising in the right mammary gland of a 63-year-old woman, was composed of well-defined solid sheets or lobules of atypical epithelial cells including many large pale or clear cells with often scalloped nuclei and coarsely vacuolated cytoplasm, in which abundant lipid droplets were identified with oil-red-O staining.
  • Besides, a subset of the tumor cells co-expressed synaptophysin, neurofilament, and PGP9.5, suggesting neuroendocrine differentiation that is a hitherto undescribed phenomenon in the mammary tumors with sebaceous features.
  • This case would expand the morphologic diversity of carcinoma of the breast.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Breast Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 16944238.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Azo Compounds; 0 / Biomarkers, Tumor; 0 / Coloring Agents; 0 / Mucin-1; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 68238-35-7 / Keratins; G7S71FND9B / oil red O
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44. Innocenzi D, Balzani A, Lupi F, Panetta C, Skroza N, Cantoresi F, Schwartz RA, Calvieri S: Morpheaform extra-ocular sebaceous carcinoma. J Surg Oncol; 2005 Dec 15;92(4):344-6
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  • [Title] Morpheaform extra-ocular sebaceous carcinoma.
  • BACKGROUND: Sebaceous carcinoma is an unusual, aggressive, malignant tumor derived from the epithelium of sebaceous glands.
  • A significant number of extra-ocular sebaceous carcinomas have been associated with metastases and high mortality rate.
  • METHODS AND RESULTS: We reviewed the literature in the context of our report of a 68-year-old woman who had a morpheaform plaque of the upper lip of 15 years duration, extending into the left naso-genal groove, which histologically also showed marked stromal fibrosis.
  • CONCLUSIONS: This patient is unusual in clinical and histologic pattern, as a morpheaform appearance has only been described previously in only one sebaceous carcinoma.
  • In addition, no metastatic disease 15 years after tumor onset is a fortunate and remarkable feature.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Lip / pathology. Scleroderma, Localized / pathology. Sebaceous Gland Neoplasms / pathology

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  • [Copyright] 2005 Wiley-Liss, Inc.
  • (PMID = 16299801.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Kiyosaki K, Nakada C, Hijiya N, Tsukamoto Y, Matsuura K, Nakatsuka K, Daa T, Yokoyama S, Imaizumi M, Moriyama M: Analysis of p53 mutations and the expression of p53 and p21WAF1/CIP1 protein in 15 cases of sebaceous carcinoma of the eyelid. Invest Ophthalmol Vis Sci; 2010 Jan;51(1):7-11
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  • [Title] Analysis of p53 mutations and the expression of p53 and p21WAF1/CIP1 protein in 15 cases of sebaceous carcinoma of the eyelid.
  • PURPOSE: The purpose of this study was to detect mutation of the p53 gene, to assess its relationship with p53 or p21(WAF1/CIP1) expression, and to evaluate the correlation between p53 mutation or p21(WAF1/CIP1) expression and clinicopathologic findings in sebaceous carcinoma of the eyelid.
  • METHODS: Fifteen conventional paraffin-embedded samples of sebaceous carcinoma of the eyelid were analyzed.
  • CONCLUSIONS: Among human cancers, sebaceous carcinoma of the eyelid may be one of those showing most frequent mutation of the p53 gene, which may not be caused by exposure to UV. p21(WAF1/CIP1) downregulation may be associated with lymph node metastasis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / genetics. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Eyelid Neoplasms / genetics. Genes, p53 / genetics. Point Mutation. Sebaceous Gland Neoplasms / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19628749.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Protein p53
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46. Izumi M, Tang X, Chiu CS, Nagai T, Matsubayashi J, Iwaya K, Umemura S, Tsuboi R, Mukai K: Ten cases of sebaceous carcinoma arising in nevus sebaceus. J Dermatol; 2008 Nov;35(11):704-11
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  • [Title] Ten cases of sebaceous carcinoma arising in nevus sebaceus.
  • Although nevus sebaceus is known to develop various types of secondary neoplasms, it rarely causes carcinoma and only 14 cases of secondary sebaceous carcinoma have been reported.
  • In this study, 10 cases of sebaceous carcinoma arising in nevus sebaceus were collected.
  • Sebaceous carcinoma arising in nevus sebaceous predominantly occurred on the scalp (8/10) of elderly women (mean age, 67.7 years).
  • We found several pathological features of sebaceous carcinoma; that is, made up mainly of germinative cells, moderate nuclear atypia without pleomorphism and many mitoses (4-28/10 high-power field).
  • Adipophilin and perilipin antibodies highlighted lipid drops in the cytoplasm of the malignant cells in all cases.
  • In two cases there were coexisting benign-looking sebaceous lesions at the periphery of the main cancer nodule, and in these lesions p53 showed low positivity compared with the clearly malignant area.
  • All cases were treated by excision of the malignant lesion, with or without inclusion of the nevus sebaceus.
  • With these specific pathological and immunohistochemical findings using adipophilin, perilipin and p53, we have to consider the possibility that there is a tendency to underdiagnose secondary sebaceous carcinomas in nevus sebaceus.
  • These clinicopathological features of sebaceous carcinomas developing in the nevus sebaceus seem to indicate different biological entities from de novo sebaceous carcinoma.
  • [MeSH-major] Carcinoma / secondary. Nevus, Sebaceous of Jadassohn / pathology. Sebaceous Gland Neoplasms / secondary. Skin / pathology

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  • (PMID = 19120764.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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47. Moustafa B, Wirbelauer C, Häberle H, Herbst H, Pham DT: [Therapy refractory blepharoconjunctivitis in a 90 year old patient]. Ophthalmologe; 2007 Oct;104(10):889-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sebaceous gland carcinoma can clinically mimic benign conditions such as chalazion and blepharoconjunctivitis.
  • This carcinoma should be histologically excluded for every unilateral, recalcitrant chalazion and every unilateral, therapy refractory blepharitis.
  • Autosomal dominant Muir-Torre syndrome should be considered in patients who develop sebaceous gland carcinoma of the ocular adnexa.
  • In this case, the sebaceous gland carcinoma is combined with visceral carcinoma.
  • [MeSH-major] Blepharitis / etiology. Eyelid Neoplasms / diagnosis. Keratoconjunctivitis / etiology. Orbital Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Biopsy. Colectomy. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Diagnosis, Differential. Eyelids / pathology. Eyelids / surgery. Female. Humans. Magnetic Resonance Imaging. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / surgery. Orbit / pathology. Palliative Care. Syndrome

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  • [Cites] Br J Ophthalmol. 1998 Sep;82(9):1049-55 [9893597.001]
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  • (PMID = 17486349.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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48. Kazakov DV, Kutzner H, Rütten A, Mukensnabl P, Michal M: Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma. Am J Dermatopathol; 2005 Jun;27(3):195-203
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma.
  • This report emphasizes a carcinoid-like pattern, a previously unrecognized feature in cutaneous sebaceous neoplasms.
  • We report 7 patients with sebaceous tumors in which neoplastic cells were arranged in a trabecular and ribbon-like pattern or formed rosettes/pseudorosettes.
  • The cases included 6 men and 1 woman, with their ages at the diagnosis ranging from 43 to 87 years (median age, 59).
  • Sebaceous differentiation in the form of mature sebocytes varied from almost none to approximately 10%.
  • Four lesions represented sebaceomas, and in 1 case microscopic delineation between a carcinoma and sebaceoma was difficult.
  • Electron microscopic examination performed in 1 case of carcinoma revealed lipid vacuoles in a minority of cells.
  • We conclude that the carcinoid-like pattern is another distinctive pattern indicative of sebaceous neoplasms.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biomarkers, Tumor / analysis. Carcinoid Tumor / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Diagnosis, Differential. Female. History, 16th Century. Humans. Immunohistochemistry. Inclusion Bodies / pathology. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / ultrastructure. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 15900121.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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49. Leibovitch I, Selva D, Huilgol S, Davis G, Dodd T, James CL: Intraepithelial sebaceous carcinoma of the eyelid misdiagnosed as Bowen's disease. J Cutan Pathol; 2006 Apr;33(4):303-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraepithelial sebaceous carcinoma of the eyelid misdiagnosed as Bowen's disease.
  • BACKGROUND: Sebaceous carcinoma (SC) is well known for its ability to masquerade clinically and histologically as a variety of periocular conditions resulting in a delayed diagnosis.
  • We present a series of periocular SC cases and discuss the difficulties in histopathological diagnosis when this tumor presents with a Bowenoid pattern of intraepithelial spread.
  • Histopathologically, 87.5% of cases were misdiagnosed as Bowen's disease (BD) on the initial biopsy.
  • Six of these cases showed no invasive disease on the initial biopsy and were eventually found to be invasive SC on subsequent excisions.
  • Delay in diagnosis ranged from 0 to 56 months.
  • CONCLUSIONS: SC should always be considered in the histological differential diagnosis of any eyelid lesion which resembles BD, particularly if the upper eyelid is involved or if multivacuolated cytoplasmic clear cell changes are seen.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Bowen's Disease / diagnosis. Eyelid Neoplasms / diagnosis. Mohs Surgery. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16630181.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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50. Xu XL, Li B, Sun XL, Li LQ, Ren RJ, Gao F: [Clinical and pathological analysis of 2639 cases of eyelid tumors]. Zhonghua Yan Ke Za Zhi; 2008 Jan;44(1):38-41
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  • The 5 leading eyelid malignant tumors were basal cell carcinoma, sebaceous gland carcinoma, lymphoma, squamous cell carcinoma and melanoma.
  • The mean age at diagnosis was 61 years for basal cell carcinoma and sebaceous gland carcinoma, 57 years and 52 years for squamous cell carcinoma and melanoma, respectively, and 48 years for lymphoma.
  • There was no significant sex predilection in basal cell carcinoma and sebaceous gland carcinoma.
  • Melanoma and lymphoma occurred more commonly in women, whereas squamous cell carcinoma occurred more commonly in men.
  • CONCLUSIONS: Basal cell carcinoma and sebaceous gland carcinoma were the most common malignant eyelid tumors, and lymphoma ranked third and had an increasing trend.
  • The malignant tumors occurred predominantly in the elderly of 60 years and above.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology. Lymphoma / pathology

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  • (PMID = 18510241.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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51. Dasgupta T, Wilson LD, Yu JB: A retrospective review of 1349 cases of sebaceous carcinoma. Cancer; 2009 Jan 1;115(1):158-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A retrospective review of 1349 cases of sebaceous carcinoma.
  • BACKGROUND: Sebaceous carcinoma is a rare and aggressive cutaneous carcinoma.
  • The median age at diagnosis was 73 years.
  • The most frequent site of disease was the eyelid (38.7%).
  • The overall population-matched rate of sebaceous carcinoma was highest in whites (2.03 cases per 1000,000; SE, 0.08) versus Asian/Pacific Islanders (1.07 per 1000,000; SE, 0.18; P=.0001) versus blacks (0.48 per 1,000,000; SE, 0.11; P<.0001).
  • CONCLUSIONS: The current results support the finding of a predominance of men among patients with sebaceous carcinoma, and no difference was observed in the prognosis for orbital and periorbital involvement.
  • This retrospective analysis also corroborated previous case reports of a higher incidence among patients with advanced age and the highest incidence for sites in the eyelid and skin of the face.
  • The results also established that Asian/Pacific Islander ancestry is not a risk factor for developing sebaceous carcinoma.
  • [MeSH-major] Head and Neck Neoplasms. Sebaceous Gland Neoplasms

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  • [Copyright] Copyright (c) 2008 American Cancer Society.
  • (PMID = 18988294.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Imakado S, Hamada K, Miura K: Low-grade sebaceous carcinoma presenting on the leg. Am J Dermatopathol; 2008 Dec;30(6):608-11

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  • [Title] Low-grade sebaceous carcinoma presenting on the leg.
  • The plaque was resected and diagnosed on microscopic examination as low-grade sebaceous carcinoma.
  • Sebaceous carcinoma on the leg seems extremely rare.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Leg. Sebaceous Gland Neoplasms / diagnosis

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  • (PMID = 19033940.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Mucin-1
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53. Altemani A, Vargas PA, Cardinali I, Aguiar SS, Lopes M, Soares AB, Speight PM, Almeida OP: Sebaceous carcinoma of the parotid gland in children: an immunohistochemical and ploidy study. Int J Oral Maxillofac Surg; 2008 May;37(5):433-40
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  • [Title] Sebaceous carcinoma of the parotid gland in children: an immunohistochemical and ploidy study.
  • Sebaceous carcinoma (SC) is a rare malignancy, affecting mainly the periocular glands.
  • The CK14 pattern depicted the monolayer of basal cells surrounding the islands of malignant tissue, while the more central sebaceous differentiated cells were negative.
  • Epithelial membrane antigen was strongly positive in the well differentiated cells, while most of the basaloid peripheral cells were negative, and only a few cells were positive for carcinoembryonic antigen. beta catenin, E cadherin and C-erb B2 were expressed by most of the cells including the more differentiated sebaceous cells.
  • [MeSH-major] Adenocarcinoma, Sebaceous / chemistry. Parotid Neoplasms / chemistry

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  • (PMID = 18396014.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Cadherins; 0 / Keratin-14; 0 / Keratin-18; 0 / Keratin-19; 0 / Mucin-1; 0 / beta Catenin; EC 2.7.10.1 / Receptor, ErbB-2
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54. Dores GM, Curtis RE, Toro JR, Devesa SS, Fraumeni JF Jr: Incidence of cutaneous sebaceous carcinoma and risk of associated neoplasms: insight into Muir-Torre syndrome. Cancer; 2008 Dec 15;113(12):3372-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidence of cutaneous sebaceous carcinoma and risk of associated neoplasms: insight into Muir-Torre syndrome.
  • BACKGROUND: Sebaceous tumors of the skin occurring in association with an internal malignancy characterize Muir-Torre syndrome (MTS), a variant of hereditary nonpolyposis colon cancer (Lynch syndrome).
  • To the authors' knowledge, only limited information exists regarding incidence patterns of sebaceous carcinoma (SC), and no prior study has quantified risks of associated cancers.

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  • (PMID = 18932259.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CP010183-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS75794; NLM/ PMC2613970
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55. Arathi C, Vijaya C: Scrape cytology in the early diagnosis of eyelid sebaceous carcinoma. J Cytol; 2010 Oct;27(4):140-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Scrape cytology in the early diagnosis of eyelid sebaceous carcinoma.
  • The low incidence and the non-specific clinical symptoms led us to conclude that the diagnosis of a sebaceous carcinoma of the eyelid often occurs very late.
  • Sebaceous carcinoma of the ocular adnexa is a malignant neoplasm which can exhibit aggressive local behavior, can have pagetoid spread and can metastasize to regional lymph nodes and distant organs.
  • The neoplasm is known to masquerade as other benign and less malignant lesions, and has relatively high morbidity and mortality.
  • Cytological smears were suggestive of sebaceous carcinoma.
  • Subsequently, histopathology confirmed the diagnosis of sebaceous gland carcinoma.
  • The article highlights the role of scrape cytology in early diagnosis and subsequent appropriate surgical management of eyelid sebaceous gland carcinoma, to prevent recurrence and metastasis.

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  • (PMID = 21157566.001).
  • [ISSN] 0974-5165
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3001202
  • [Keywords] NOTNLM ; Sebaceous carcinoma / eyelid / scrape cytology
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56. Yoon JS, Kim SH, Lee CS, Lew H, Lee SY: Clinicopathological analysis of periocular sebaceous gland carcinoma. Ophthalmologica; 2007;221(5):331-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological analysis of periocular sebaceous gland carcinoma.
  • BACKGROUND: We analyzed the clinicopathological features and prognosis in patients with periocular sebaceous gland carcinoma.
  • METHODS: Retrospectively, we studied the records of 24 cases of sebaceous gland carcinoma treated in our clinic between 1999 and 2004.
  • The reviewed data included demographic information, initial clinical and histopathological diagnosis, anatomic tumor location, details of treatment, tumor involvement of resection margin, and outcomes such as local recurrence, distant metastasis and survival.
  • RESULTS: Local recurrence developed in 6 cases (25%) at a median of 20 months from initial diagnosis.
  • Only 2 patients (8.3%) died of systemic metastasis to brain and bone from primary lacrimal gland carcinoma.
  • Early aggressive management is required in sebaceous gland carcinoma of the lacrimal gland, as its mortality is much higher than that of eyelid origin.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Eyelid Neoplasms / pathology. Eyelid Neoplasms / surgery. Sebaceous Gland Neoplasms / pathology. Sebaceous Gland Neoplasms / surgery

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17728556.001).
  • [ISSN] 1423-0267
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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57. Hammedi F, Trabelsi A, Belajouza C, Beïzig N, Gannouchi N, Sriha B, Mokni M: Extra ocular sebaceous carcinoma of the thigh: A case report. N Am J Med Sci; 2010 Jan;2(1):48-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra ocular sebaceous carcinoma of the thigh: A case report.
  • CONTEXT: Sebaceous cell carcinoma is a malignant neoplasm, rarely recognized in extra ocular sites.
  • His prognosis depends of the precocity of the diagnosis.
  • It suspected a squamous cell carcinoma.
  • The histologic findings revealed an extra ocular sebaceous carcinoma.
  • CONCLUSION: extra ocular sebaceous carcinoma is a rare neoplasm.
  • It has more difficulties of diagnosis because it has diverse clinical presentations as well as a variety of histologic patterns.

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  • [Cites] Ann Dermatol Venereol. 2006 Feb;133(2):165-7 [16508603.001]
  • [Cites] J Med Case Rep. 2008;2:276 [18706083.001]
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  • (PMID = 22624114.001).
  • [ISSN] 2250-1541
  • [Journal-full-title] North American journal of medical sciences
  • [ISO-abbreviation] N Am J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3354389
  • [Keywords] NOTNLM ; Extra-ocular / Sebaceous cell carcinoma / histopathology
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58. Iglesias I, Troyano J, Díaz-Valle D, Genol I: [Sebaceous carcinoma. Study of two cases]. Arch Soc Esp Oftalmol; 2008 Jul;83(7):445-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sebaceous carcinoma. Study of two cases].
  • [Transliterated title] Carcinoma de glándulas sebáceas: presentación de dos casos clínicos.
  • A 67-year-old woman, previously operated on for a sebaceous carcinoma, presented because of reddening of the conjunctiva and eyelid.
  • DISCUSSION: A sebaceous carcinoma is a tumour which is difficult to diagnose and treat, because it can be patchy and has a tendency to pagetoid dissemination.
  • Diagnosis requires a biopsy of the lesion and mapping of biopsies from the conjunctiva of the eyelid and eyebrow.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Eyelid Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis

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  • (PMID = 18592447.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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59. Priyadarshini O, Biswas G, Biswas S, Padhi R, Rath S: Neoadjuvant chemotherapy in recurrent sebaceous carcinoma of eyelid with orbital invasion and regional lymphadenopathy. Ophthal Plast Reconstr Surg; 2010 Sep-Oct;26(5):366-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoadjuvant chemotherapy in recurrent sebaceous carcinoma of eyelid with orbital invasion and regional lymphadenopathy.
  • Histopathology showed it to be invasive sebaceous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Eyelid Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy. Orbital Neoplasms / drug therapy. Sebaceous Gland Neoplasms / drug therapy

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  • (PMID = 20856079.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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60. Demirci H, Nelson CC, Shields CL, Eagle RC Jr, Shields JA: Eyelid sebaceous carcinoma associated with Muir-Torre syndrome in two cases. Ophthal Plast Reconstr Surg; 2007 Jan-Feb;23(1):77-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eyelid sebaceous carcinoma associated with Muir-Torre syndrome in two cases.
  • We report the rare but serious association between sebaceous carcinoma of eyelid and Muir-Torre syndrome in two cases, a 79-year-old woman and 54-year-old man.
  • A history of multiple primary colon cancers was present in both patients, associated transitional cell carcinoma of bladder and renal cancer in one patient and prostate cancer in the other.
  • Histopathology revealed sebaceous carcinoma of eyelid and conjunctiva.
  • Muir-Torre syndrome was diagnosed on the basis of sebaceous carcinoma, associated with multiple visceral malignancies in both patients.
  • We conclude that patients with sebaceous carcinoma should have evaluation for visceral malignancies, mainly colon cancer.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyelid Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Transitional Cell. Colonic Neoplasms / pathology. Cryotherapy. Female. Humans. Kidney Neoplasms / pathology. Male. Middle Aged. Urinary Bladder Neoplasms / pathology

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  • (PMID = 17237705.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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61. Al-Shobaili HA, AlGhamdi KM, Al-Ghamdi WA: Cystic sebaceous carcinoma: is it a constant pathognomic marker for Muir-Torre syndrome? J Drugs Dermatol; 2007 May;6(5):540-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic sebaceous carcinoma: is it a constant pathognomic marker for Muir-Torre syndrome?
  • Sebaceous carcinoma (SC) is a rare and aggressive cutaneous neoplasm.
  • Cystic presentation of sebaceous neoplasm is rare.
  • So far, cystic sebaceous neoplasia (CSN) has been reported only in association with Muir-Torre syndrome (MTS).
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Neoplasms, Cystic, Mucinous, and Serous / pathology. Skin Neoplasms / pathology

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  • (PMID = 17679191.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Jain P, Nanda A, Handa U, Bal A, Mohan H, Gupta SK: FNA diagnosis of recurrent sebaceous carcinoma. Diagn Cytopathol; 2006 Feb;34(2):124-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FNA diagnosis of recurrent sebaceous carcinoma.
  • We describe fine-needle aspiration (FNA) diagnosis in a case of sebaceous carcinoma presenting as recurrent swelling eyelid.
  • A final impression of sebaceous carcinoma of the left upper eyelid was rendered, based on which the eyelid mass was radically excised.
  • Subsequent histopathology confirmed the diagnosis.
  • An early and accurate diagnosis of such lesions can be established on minimally invasive needle aspiration.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Adenocarcinoma, Sebaceous / pathology. Sebaceous Glands / pathology

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  • [Copyright] 2006 Wiley-Liss, Inc.
  • (PMID = 16511848.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Cabral ES, Cassarino DS: Desmoplastic tricholemmoma of the eyelid misdiagnosed as sebaceous carcinoma: a potential diagnostic pitfall. J Cutan Pathol; 2007 Dec;34 Suppl 1:22-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoplastic tricholemmoma of the eyelid misdiagnosed as sebaceous carcinoma: a potential diagnostic pitfall.
  • BACKGROUND: Sebaceous carcinoma (SC) most commonly presents on the eyelid and is frequently misdiagnosed both clinically and pathologically.
  • Therefore, DTL should enter the differential diagnosis of clear-cell neoplasms on the eyelid.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Eyelid Neoplasms / diagnosis. Hair Diseases / diagnosis. Hair Follicle / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Glycogen / metabolism. Humans. Male. Middle Aged

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  • (PMID = 17997733.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 9005-79-2 / Glycogen
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64. Alzaraa A, Ghafoor I, Yates A, Dhebri A: Sebaceous carcinoma of the skin of the breast: a case report. J Med Case Rep; 2008;2:276

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma of the skin of the breast: a case report.
  • INTRODUCTION: Sebaceous gland tumours are rare and their presence should be considered as a marker for Muir-Torre Syndrome, alerting to search for an occult malignancy.
  • CASE PRESENTATION: A 43-year-old Caucasian female patient underwent excision of a sebaceous cyst.
  • Histopathology confirmed a sebaceous carcinoma.
  • CONCLUSION: Sebaceous carcinoma should be excised completely and followed-up for the detection of possible metastases.

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  • [Cites] World J Surg Oncol. 2006;4:8 [16466577.001]
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  • (PMID = 18706083.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2527503
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65. Ghosh SK, Bandyopadhyay D, Gupta S, Chatterjee G, Ghosh A: Rapidly growing extraocular sebaceous carcinoma occurring during pregnancy: a case report. Dermatol Online J; 2008;14(8):8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapidly growing extraocular sebaceous carcinoma occurring during pregnancy: a case report.
  • Sebaceous carcinoma is a very rare, aggressive, malignant tumor derived from the adnexal epithelium of sebaceous glands.
  • Despite the widespread anatomic distribution of sebaceous glands, extraocular sebaceous carcinoma is very rare, comprising only (1/4) of all reported cases of sebaceous carcinoma.
  • Extraocular sebaceous carcinoma in the post-auricular region or in the external auditory canal is very rarely described in the literature.
  • A case of a rapidly growing sebaceous carcinoma of the pinna occurring in a pregnant woman is reported here for its rarity.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Ear Neoplasms / pathology. Ear, External / pathology. Pregnancy Complications, Neoplastic / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Disease Progression. Female. Humans. Pregnancy

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  • (PMID = 19061568.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Asadi-Amoli F, Khoshnevis F, Haeri H, Jahanzad I, Pazira R, Shahsiah R: Comparative examination of androgen receptor reactivity for differential diagnosis of sebaceous carcinoma from squamous cell and basal cell carcinoma. Am J Clin Pathol; 2010 Jul;134(1):22-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative examination of androgen receptor reactivity for differential diagnosis of sebaceous carcinoma from squamous cell and basal cell carcinoma.
  • Sebaceous carcinoma (SEB) is the most important malignant tumor of the eyelid.
  • Early diagnosis and proper treatment significantly improve the outcome.
  • SEB should be differentiated histopathologically from basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
  • In this study, the expression of androgen receptor (AR) in SEB, SCC, and BCC was evaluated.
  • AR was positive in all 19 SEB cases.
  • AR is a sensitive marker for SEB, especially in less differentiated tumors.
  • Along with other markers and morphologic features, AR can be helpful in the diagnosis of SEB and its differentiation from SCC and BCC.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Eyelid Neoplasms / diagnosis. Receptors, Androgen / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Male

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  • (PMID = 20551262.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Androgen
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67. Takamura H, Yamashita H: Clinicopathological analysis of malignant eyelid tumor cases at Yamagata university hospital: statistical comparison of tumor incidence in Japan and in other countries. Jpn J Ophthalmol; 2005 Sep-Oct;49(5):349-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological analysis of malignant eyelid tumor cases at Yamagata university hospital: statistical comparison of tumor incidence in Japan and in other countries.
  • PURPOSE: To report the clinical and histopathological features of malignant eyelid tumor cases treated in our clinic.
  • We also compared the differences in the frequency of malignant eyelid tumor in various regions of Japan and worldwide.
  • METHODS: Retrospectively, we studied the records of the 38 cases of malignant eyelid tumor treated in Yamagata University Hospital over the last 17 years.
  • RESULTS: Data from our clinic: Among the total of 38 cases, 15 cases (39.5%) were diagnosed as basal cell carcinoma, 11 cases (28.9%) as sebaceous gland carcinoma, and 4 cases (10.5%) as squamous cell carcinoma.
  • In addition, three cases were malignant melanoma, two adenocarcinoma, one Merkel cell carcinoma, one malignant peripheral nerve sheath tumor, and one malignant lymphoma.
  • The prognosis of the cases with basal cell carcinoma and squamous cell carcinoma was good, and that of the other tumors was relatively poor.
  • During the same period, in Caucasians, basal cell carcinoma constituted about 80%-90% of the malignant eyelid tumors, whereas in Japan and Asian countries, basal cell carcinoma, sebaceous gland carcinoma, and squamous cell carcinoma each constituted about 20%-40%.
  • CONCLUSIONS: A racial difference in the incidence of basal cell carcinoma, sebaceous gland carcinoma, and squamous cell carcinoma can be considered in making a diagnosis.

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  • (PMID = 16187033.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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68. Bouraoui S, Khaddar RK, Mokni M, Badri T, Azaiez MY, Dhahri AB: [Extrapalpebral sebaceous carcinoma]. Ann Dermatol Venereol; 2006 Feb;133(2):165-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extrapalpebral sebaceous carcinoma].
  • [Transliterated title] Carcinome sébacé extra-palpébral.
  • Extra ocular sebaceous carcinoma is a rare carcinoma of the skin known to have difficulties of diagnosis because of its polymorphism of clinical and histopathological findings.
  • His prognosis depends of the precocity of the diagnosis.
  • It suspected a squamous cell carcinoma.
  • The histologic findings revealed a sebaceous carcinoma in his mixed and moderately differentiated type.
  • COMMENTS: Sebaceous carcinoma exhibits a variety of histologic growth patterns and diverse clinical presentations that the diagnosis is often difficult.
  • We discuss incidence as well as clinical, histological and established the diagnosis and the prognosis of this aggressive neoplasm.
  • [MeSH-major] Carcinoma. Facial Neoplasms. Sebaceous Gland Neoplasms

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  • (PMID = 16508603.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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69. Yang HM, Cabral E, Dadras SS, Cassarino DS: Immunohistochemical expression of D2-40 in benign and malignant sebaceous tumors and comparison to basal and squamous cell carcinomas. Am J Dermatopathol; 2008 Dec;30(6):549-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of D2-40 in benign and malignant sebaceous tumors and comparison to basal and squamous cell carcinomas.
  • The diagnosis of sebaceous carcinoma presents an important challenge to both clinicians and pathologists, as many cases are initially misdiagnosed both clinically and histopathologically, potentially leading to adverse medical and legal outcomes.
  • The distinction of sebaceous carcinoma from benign sebaceous proliferations and other tumors is therefore of utmost importance, and immunohistochemistry may be useful in this differential.
  • We studied the expression of D2-40 (podoplanin) by immunohistochemistry to determine if it can aid in this differential diagnosis and to evaluate the possibility of lymphangiogenesis in sebaceous carcinoma.
  • A total of 36 cases of sebaceous lesions, including 16 sebaceous carcinomas, 7 sebaceous adenomas, 6 sebaceomas, and 7 cases of normal glands and sebaceous hyperplasia, and 17 cases of basal cell carcinoma and 10 cases of squamous cell carcinoma, were also examined.
  • We found no significant increase in tumor lymphangiogenesis by semiquantitative scoring of lymphovascular density per square millimeter of tumoral/peritumoral stroma in sebaceous carcinoma versus benign sebaceous proliferations.
  • However, D2-40 staining showed a different pattern in the benign tumors, which were positive only in the basaloid cells (most pronounced in sebaceoma), versus sebaceous carcinoma, which was either negative or focally positive in a haphazard pattern in most cases, although some cases of basaloid sebaceous carcinomas showed strong positivity.
  • We also found D2-40 to be only weakly and focally positive in basal cell carcinoma and weakly to moderately positive in squamous cell carcinoma, which showed increased staining with decreased differentiation.
  • Therefore, overall, D2-40 is, of limited diagnostic utility in sebaceous lesions but may be useful in distinguishing sebaceoma and basaloid sebaceous carcinoma from basal cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Antibodies, Monoclonal / metabolism. Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Glands / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / metabolism. Adenoma / pathology. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Case-Control Studies. Cell Proliferation. Diagnosis, Differential. Humans. Hyperplasia / diagnosis. Hyperplasia / metabolism. Hyperplasia / pathology

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  • (PMID = 19033927.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
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70. Levy J, Cagnano E, Benharroch D, Monos T, Lifshitz T: Collision sebaceous and basal cell carcinomas of the eyelid. Ann Diagn Pathol; 2006 Jun;10(3):157-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collision sebaceous and basal cell carcinomas of the eyelid.
  • OBJECTIVE: To report a rare case of collision sebaceous and basal cell carcinomas of the eyelid.
  • Histopathology showed mixed sebaceous as well as basal cell carcinoma with uninvolved surgical margins.
  • CONCLUSION: Sebaceous and basal cell carcinomas can coexist in the eyelid within the same clinical lesion.
  • Because of the potential risk of metastasis of sebaceous carcinoma, close follow-up of the patients is advisable.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16730311.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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71. Calder KB, Khalil FK, Schlauder S, Cualing HD, Morgan MB: Immunohistochemical expression of survivin in cutaneous sebaceous lesions. Am J Dermatopathol; 2008 Dec;30(6):545-8
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  • [Title] Immunohistochemical expression of survivin in cutaneous sebaceous lesions.
  • Survivin overexpression has been demonstrated in numerous malignancies including cutaneous squamous cell carcinoma and melanoma.
  • To date, there are no studies evaluating the expression of survivin in sebaceous neoplasms.
  • METHODS: Immunohistochemical expression of survivin was evaluated in a total of 20 extraocular sebaceous neoplasms: sebaceous hyperplasia (SH, 8), sebaceous adenoma (SA, 8), and sebaceous carcinoma (SC, 4).
  • These findings demonstrate the potential diagnostic utility of survivin, further assisting in the microscopic differentiation of benign and malignant sebaceous neoplasms.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Adenoma / metabolism. Microtubule-Associated Proteins / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Glands / metabolism. Sebaceous Glands / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Case-Control Studies. Cell Nucleus / metabolism. Diagnosis, Differential. Female. Humans. Hyperplasia / diagnosis. Hyperplasia / metabolism. Hyperplasia / pathology. Inhibitor of Apoptosis Proteins / metabolism. Male. Middle Aged

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  • (PMID = 19033926.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
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72. Gomes CC, Lacerda JC, Pimenta FJ, do Carmo MA, Gomez RS: Intraoral sebaceous carcinoma. Eur Arch Otorhinolaryngol; 2007 Jul;264(7):829-32
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  • [Title] Intraoral sebaceous carcinoma.
  • Intraoral sebaceous carcinoma (SC) is a rare tumour in the oral cavity thought to arise from malignant transformation of oral sebaceous glands.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Mouth Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Radiography, Panoramic. Tomography, X-Ray Computed

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  • [Cites] Dermatologica. 1962;125:44-63 [13902791.001]
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  • (PMID = 17285332.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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73. Ivan D, Prieto VG, Esmaeli B, Wistuba II, Tang X, Lazar AJ: Epidermal growth factor receptor (EGFR) expression in periocular and extraocular sebaceous carcinoma. J Cutan Pathol; 2010 Feb;37(2):231-6
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  • [Title] Epidermal growth factor receptor (EGFR) expression in periocular and extraocular sebaceous carcinoma.
  • Sebaceous carcinoma has a predominant periocular origin but can also be extraocular.
  • There is no effective treatment for metastatic sebaceous carcinoma.
  • Extraocular carcinomas showed markedly increased levels of EGFR when compared to periocular carcinoma cases, both in terms of distribution (88% were > 25% of tumor cells vs. 16%) and intensity (77% were 2+ or 3+ vs. 21%) (p < 0.001).
  • Our results underscore the divergent mechanisms underlying the tumorigenesis of periocular and extraocular sebaceous carcinoma and suggest an association between aggressive behavior and increased EGFR expression in extraocular sebaceous carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Receptor, Epidermal Growth Factor / metabolism. Sebaceous Gland Neoplasms / metabolism

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  • (PMID = 19614729.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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74. Heyl J, Mehregan D: Immunolabeling pattern of cytokeratin 19 expression may distinguish sebaceous tumors from basal cell carcinomas. J Cutan Pathol; 2008 Jan;35(1):40-5
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  • [Title] Immunolabeling pattern of cytokeratin 19 expression may distinguish sebaceous tumors from basal cell carcinomas.
  • BACKGROUND: Distinction between sebaceous tumors and basal cell carcinomas can often pose diagnostic problems.
  • Our aim was to evaluate the use of CK 19 staining patterns in differentiating between sebaceous tumors and basal cell carcinomas.
  • The sebaceous tumors that were examined in this study included sebaceous adenomas, sebaceous epitheliomas (sebaceomas) and sebaceous carcinomas.
  • METHODS: Thirty-seven cases including 5 sebaceous adenomas, 16 sebaceous epitheliomas, 6 sebaceous carcinomas and 14 basal cell carcinomas (7 being of the morpheaform type and 7 nodular basal cell carcinomas) were tested with a monoclonal mouse antibody to human CK 19.
  • RESULTS: CK 19 was focally positive in 1/5 (20%) sebaceous adenomas, 8/16 (50%) of sebaceous epitheliomas and 1/6 (17%) of sebaceous carcinomas.
  • Strongly positive expression of CK 19 was not seen in any of the sebaceous adenoma, sebaceous epithelioma or sebaceous carcinoma specimens.
  • CONCLUSION: CK 19 expression can be helpful in differentiating sebaceous tumors (including sebaceous adenomas, sebaceous epitheliomas and sebaceous carcinomas) from basal cell carcinomas and may be a useful adjunct when these entities are included in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Adenoma / diagnosis. Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Keratin-19 / analysis. Sebaceous Gland Neoplasms / diagnosis. Sebaceous Glands / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Humans. Middle Aged

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  • (PMID = 18095993.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-19
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75. Becker K, Goldberg M, Helmbold P, Holbach LM, Loeffler KU, Ballhausen WG: Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas. Br J Dermatol; 2008 Dec;159(6):1282-9
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  • [Title] Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas.
  • BACKGROUND: Sebaceous gland carcinomas represent rare malignancies of the skin and some 60% of them demonstrate high-grade microsatellite instability on the background of a defective mismatch repair system.
  • However, a significant fraction of periocular sebaceous gland carcinomas exhibits microsatellite stability associated with a frequent loss of the candidate tumour suppressor fragile histidine triad (FHIT).
  • OBJECTIVES: We hypothesized that in those sebaceous gland carcinomas with microsatellite stability and loss of FHIT, effector molecules participating in homologous recombination repair (HRR), such as BRCA1/2, could be somatically inactivated.
  • METHODS: A pilot series of 10 paraffin-embedded sebaceous gland carcinoma specimens with a defined FHIT status was studied for loss of heterozygosity (LOH) events in the genes BRCA1, BRCA2, FHIT and WWOX.
  • RESULTS: Sebaceous gland carcinomas with FHIT negativity displayed LOH and biallelic deletions of the BRCA1 gene in five of 10 (50%) of the sebaceous gland carcinoma specimens analysed.
  • A homozygous p53 R248W gain-of-function mutation as the result of a CGG to TGG transition was identified in one of seven sebaceous gland carcinomas.
  • This particular sebaceous gland carcinoma presented with concomitant genomic deletions at the BRCA1 and BRCA2 loci, and also at the constitutively fragile sites FRA3B/FHIT and FRA16D/WWOX.
  • CONCLUSIONS: Our study demonstrates for the first time that microsatellite-stable FHIT-negative sebaceous gland carcinomas accumulate mutations that target central components of the HRR network.
  • This observation will prompt investigations in synthetic lethality of BRCA-deficient sebaceous gland carcinomas by therapeutic poly(ADP-ribose) polymerase inhibitors.
  • [MeSH-major] Acid Anhydride Hydrolases / genetics. Adenocarcinoma, Sebaceous / genetics. Genes, BRCA1. Genes, BRCA2. Neoplasm Proteins / genetics. Sebaceous Gland Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 18717684.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Protein p53; 0 / fragile histidine triad protein; EC 3.6.- / Acid Anhydride Hydrolases
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76. Kazakov DV, Calonje E, Zelger B, Luzar B, Belousova IE, Mukensnabl P, Michal M: Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases. Am J Dermatopathol; 2007 Jun;29(3):242-8
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  • [Title] Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases.
  • The authors report a small series of sebaceous carcinoma developing in nevus sebaceus of Jadassohn (also known as organoid nevus) and analyze similar cases reported in the literature.
  • All sebaceous carcinomas manifested unquestionable architectural (asymmetry, invasive growth) and cytological features of a carcinoma (cellular and nuclear pleomorphism, plentiful atypical mitoses, necroses en masse), demonstrated unambiguous sebaceous differentiation in the form of mature sebocytes, and lacked other differentiations.
  • The sebaceous carcinoma was always accompanied by other benign or malignant adnexal lesions such as sebaceoma, syringocystadenoma papilliferum, syringocystadenocarcinoma papilliferum, trichoblastoma, tricholemmoma, desmoplastic tricholemmoma, or syringoma.
  • The analysis of the previously published material and our cases indicates that sebaceous carcinoma arising in organoid nevus has a female predilection and tends to occur in elderly patients.
  • It may involve any site where nevus sebaceus typically occurs.
  • It may arise alone, but it occurs more frequently as part of multiple benign and malignant adnexal tumors.
  • The tumor seems to be a low-grade carcinoma in terms of clinical behavior.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 17519621.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Manonukul J, Kajornvuthidej S: Sebaceous neoplasms in Siriraj Hospital, Mahidol University: a 9-year-retrospective study. J Med Assoc Thai; 2010 Aug;93(8):978-91
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  • [Title] Sebaceous neoplasms in Siriraj Hospital, Mahidol University: a 9-year-retrospective study.
  • BACKGROUND: Sebaceous neoplasms are adnexal neoplasms that contain a varying number ofsebocytes, i.e. large cells with lipid-laden vacuolated cytoplasm, soap-bubble in appearance, and crenate nuclei.
  • Various sebaceous neoplasms with complex histopathologic features and varying degree ofsebaceous cells differentiation have been described in the literature.
  • OBJECTIVES: To study the prevalence of sebaceous neoplasms, i.e., nevus sebaceus, sebaceous hyperplasia, sebaceous adenoma, sebaceoma, sebaceous epithelioma, superficial epithelioma with sebaceous differentiation, and sebaceous carcinoma diagnosed in the Department of Pathology, Siriraj Hospital, Mahidol University during the 9-year-period between 1997 and 2005.
  • To study the prevalence of tumor transformation that occurs in nevus sebaceus.
  • MATERIAL AND METHOD: A retrospective study of all sebaceous neoplasms including Nevus sebaceous, sebaceous hyperplasia, sebaceous adenoma, sebaceoma, sebaceous epithelioma, superficial epithelioma with sebaceous differentiation, sebaceous carcinoma, and all neoplasms containing the term "sebaceous" was performed.
  • All slides were re-analyzed and re-diagnosed, without knowledge of the previous diagnosis or any clinical data, according to the criteria described in the standard textbooks of dermatopathology by Elder, McKee.
  • Comparison between the previous diagnoses and the reviewed diagnoses was performed to assess the initial accuracy of all sebaceous neoplasms diagnosed.
  • Small-sized biopsies or biopsies that possess incomplete sebaceous differentiation, in which the sebocytes were few and subtle, sometimes are difFicult to diagnose.
  • In these instances, the clinical correlation was needed for positive diagnosis.
  • RESULTS: Two hundred seven sebaceous neoplasms (2.34%) from the 8819 skin biopsies that were taken in the Department of Pathology, Siriraj Hospital during the 9-year-period, were included After exclusion of some authentically non-sebaceous neoplasms, 182 sebaceous neoplasms were found Nevus sebaceus (n=85, 46.7%) and sebaceous hyperplasia (n=64, 35.1%) were the two most common benign lesions.
  • The others were sebaceoma (n=3, 1.6%), sebaceous adenoma (n=2, 1.1%), sebaceous epithelioma (n=1, 0.5%), sebaceous carcinoma (n=26, 14.3%), and one unclassified sebaceous lesion that could not be considered a neoplasm.
  • Tumor degeneration was found in 14 nevus sebaceus in which 21 neoplasms existed, namely, trichilemmoma (wart)-like lesion (n=4), primitive follicular induction (n=7), syringocystadenoma papilliferum (n=3), trichoblastoma (n=3), and one of each of trichoepithelioma, sebaceous adenoma, tumor of follicular infundiculum, and mucoepidermoid carcinoma.
  • CONCLUSION: Twenty-six sebaceous carcinomas out of 182 sebaceous neoplasms, occurring mostly on the patients'eyelids, were found The most common sebaceous neoplasm was nevus sebaceus (n=85); the prophylactic excision of this lesion was recommended as tumor degeneration was frequent (14 out of 85 cases).
  • It was very helpful in the detection of sebocytes in basaloid cells in sebaceous neoplasms and among lymphoid cells within metastasized lymph nodes and a discriminant between sebaceous and nonsebaceous neoplasms.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 20718175.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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78. Bernardini FP: Management of malignant and benign eyelid lesions. Curr Opin Ophthalmol; 2006 Oct;17(5):480-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of malignant and benign eyelid lesions.
  • PURPOSE OF REVIEW: The management of benign and malignant eyelid neoplasms has been extensively examined.
  • In the malignant group, a consensus has been reached over the preferred method of tumor excision for basal cell carcinoma: Mohs surgery or complete surgical excision with frozen-section control of the margins offers the lowest tumor-recurrence rate.
  • Intraepithelial tumor growth is a peculiar feature of sebaceous gland carcinoma that seems to indicate an increased risk for orbital invasion.
  • Recent reports regarding the rare tumor, Merkel cell carcinoma, recommend a wide surgical excision with 5 mm margins; this may reduce the incidence of lymph-node metastasis, haematogenous spread and local recurrences.
  • SUMMARY: Although treatment of the most common benign and malignant tumours affecting the eyelids has not radically changed over the years, recent reports have significantly improved the standard of care for affected patients.

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  • (PMID = 16932064.001).
  • [ISSN] 1040-8738
  • [Journal-full-title] Current opinion in ophthalmology
  • [ISO-abbreviation] Curr Opin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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79. Xu XL, Li B, Sun XL, Li LQ, Ren RJ, Gao F, Jonas JB: Eyelid neoplasms in the Beijing Tongren Eye Centre between 1997 and 2006. Ophthalmic Surg Lasers Imaging; 2008 Sep-Oct;39(5):367-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Of the 2,639 eyelid specimens, 2,276 (86.2%) were benign and 363 (13.8%) were malignant.
  • The most common malignant or semi-malignant tumors were basal cell carcinomas, sebaceous gland carcinomas, lymphomas, squamous cell carcinomas, and malignant melanomas.
  • The mean age at diagnosis was 41 years for benign lesions and 60 years for malignant tumors.
  • CONCLUSION: At the BeijingTongren Eye Centre between 1997 and 2006, the predominant non-benign eyelid tumors were basal cell carcinoma and sebaceous gland carcinoma, followed by lymphoma.

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  • (PMID = 18831417.001).
  • [ISSN] 1542-8877
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Dickinson RM, Young KM: Cutaneous mass aspirate from a Golden Retriever: "glandular guile". Vet Clin Pathol; 2005 Dec;34(4):421-4

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  • A 3-year-old, neutered, male Golden Retriever was presented for evaluation of a 10 X 9 X 5 mm, firm, red, raised, cutaneous mass located over the left cranial thorax and noted incidentally by the owner.
  • On cytologic evaluation of a fine-needle aspirate of the mass, the interpretation was a malignant tumor with predominantly mesenchymal features.
  • Differentials included liposarcoma, atypical amelanotic melanoma, anaplastic sarcoma, and anaplastic carcinoma.
  • Following complete excision of the mass, a diagnosis of sebaceous adenocarcinoma was made based on histologic features, positive immunostaining for pancytokeratin, and negative staining for vimentin, Melan-A, and S-100.
  • The unique and previously unreported cytologic features of this small, sebaceous adenocarcinoma were the extreme pleomorphism, including marked anisocytosis, anisokaryosis, and multinuclearity, and the paucity of epithelial features.

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  • (PMID = 16270273.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
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81. Matsuda K, Doi T, Kosaka H, Tasaki N, Yoshioka H, Kakibuchi M: Sebaceous carcinoma arising in nevus sebaceus. J Dermatol; 2005 Aug;32(8):641-4
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  • [Title] Sebaceous carcinoma arising in nevus sebaceus.
  • The surrounding epithelial changes were consistent with nevus sebaceus.
  • From these findings, the gigantic tumor was diagnosed as a sebaceous carcinoma arising in nevus sebaceus.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Nevus / diagnosis. Sebaceous Gland Neoplasms / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Cheek. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasms, Multiple Primary

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  • (PMID = 16334864.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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82. Hernández JF, Santiago RS: [Sebaceous gland carcinoma of the eyelids]. Cir Cir; 2006 Nov-Dec;74(6):509-10

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  • [Title] [Sebaceous gland carcinoma of the eyelids].
  • [Transliterated title] Carcinoma de glándulas sebáceas de los párpados.
  • [MeSH-major] Eyelid Neoplasms / genetics. Neoplastic Syndromes, Hereditary / genetics. Sebaceous Gland Neoplasms / genetics

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  • [CommentOn] Cir Cir. 2004 Jan-Feb;72(1):47-53 [15087053.001]
  • (PMID = 17244511.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Comment; Letter
  • [Publication-country] Mexico
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83. Ahn SH, Park SY: Sebaceous lymphadenocarcinoma of parotid gland. Eur Arch Otorhinolaryngol; 2006 Oct;263(10):940-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous lymphadenocarcinoma of parotid gland.
  • The sebaceous lymphadenocarcinoma of the salivary glands is extremely rare and represents carcinomatous transformation of sebaceous lymphadenoma.
  • A patient who presented with a recent increase of a left infraauricular mass, of more than 10 years duration, underwent surgery.
  • The microscopic examination revealed a typical sebaceous lymphadenoma with transition to a sebaceous adenocarcinoma.
  • After postoperative adjuvant radiotherapy, the patient remains disease-free at 24 months postoperatively.
  • We here report a fifth case of this tumor and the youngest age at diagnosis among reported cases.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Adenolymphoma / diagnosis. Parotid Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis

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  • [Cites] Ann Diagn Pathol. 2003 Aug;7(4):236-9 [12913846.001]
  • [Cites] Surgeon. 2005 Apr;3(2):67-72 [15861939.001]
  • [Cites] Arch Pathol. 1974 Nov;98(5):320-4 [4415696.001]
  • (PMID = 16786364.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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84. Obata H, Aoki Y, Kubota S, Kanai N, Tsuru T: [Incidence of benign and malignant lesions of eyelid and conjunctival tumors]. Nippon Ganka Gakkai Zasshi; 2005 Sep;109(9):573-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Incidence of benign and malignant lesions of eyelid and conjunctival tumors].
  • PURPOSE: To examine the incidence of benign and malignant eyelid lesions and conjunctival tumors.
  • The incidence of benign or malignant lesions, the pathological classification, age, sex, and clinical diagnostic accuracy were all investigated.
  • Twenty-four (27%) eyelid tumors were malignant.
  • These included 9 basal cell carcinomas, 9 sebaceous gland carcinomas, 4 malignant lymphomas, and 2 metastatic tumors.
  • Nine (21%) conjunctival tumors were malignant, comprising 7 malignant lymphomas and 2 squamous cell carcinomas.
  • The mean ages of malignant eyelid and conjunctival tumor patients were significantly older than those of benign tumor patients.
  • Clinical accuracy in predicting basal cell carcinoma and sebaceous gland carcinoma was 11.1% and 44.4%, respectively.
  • Clinicians should suspect that the lesions are malignant when seeing elderly patients with eyelid or conjunctival tumors.
  • Excised eyelid lesions should be submitted for histopathologic confirmation because there are some cases where clinical diagnosis does not match pathological diagnosis.
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Female. Humans. Incidence. Lymphoma / epidemiology. Lymphoma / pathology. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16218435.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 27
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85. Kumar R: Clinicopathologic study of malignant eyelid tumours. Clin Exp Optom; 2010 Jul;93(4):224-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic study of malignant eyelid tumours.
  • BACKGROUND: Early diagnosis of malignancy of eyelids can save the visual system from metastasis.
  • RESULTS: A total of 37 malignant eyelid tumours were seen.
  • Sebaceous gland carcinoma was the commonest (40.5 per cent) finding, followed by squamous cell carcinoma (27 per cent), basal cell carcinoma (24.3 per cent), basosquamous carcinoma (5.4 per cent) and malignant melanoma (2.7 per cent).
  • CONCLUSIONS: As the most common tumour in the region, sebaceous gland carcinoma might be due to geographical and environmental variations and requires immediate consultation and histopathologic diagnosis of lid lesions above 40 years of age for treatment strategies.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Carcinoma / epidemiology. Carcinoma / pathology. Carcinoma, Basosquamous / epidemiology. Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Child. Female. Humans. Incidence. Male. Middle Aged. Nepal / epidemiology. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / pathology. Sex Distribution. Young Adult

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  • (PMID = 20465547.001).
  • [ISSN] 1444-0938
  • [Journal-full-title] Clinical & experimental optometry
  • [ISO-abbreviation] Clin Exp Optom
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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86. Pornpanich K, Chindasub P: Eyelid tumors in Siriraj Hospital from 2000-2004. J Med Assoc Thai; 2005 Nov;88 Suppl 9:S11-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: There were 53 (17.8%) inflammatory conditions, 212 (71.4%) benign eyelid tumors and 32 (10.8%) malignant eyelid tumors.
  • These 32 malignant eyelid tumors included 13 sebaceous gland carcinomas, 12 basal cell carcinomas, 3 malignant melanomas, 2 squamous cell carcinomas, 1 apocrine adenocarcinoma and 1 metastatic carcinoma.
  • CONCLUSION: The majority of eyelid lesions were benign eyelid tumors while malignant eyelid tumors contributed 10.8% of the total eyelid lesions.
  • Sebaceous gland carcinoma was the most common eyelid tumor found in their present study that was consistent with other studies from Asian countries.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Eyelid Neoplasms / epidemiology. Sebaceous Gland Neoplasms / epidemiology

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  • (PMID = 16681045.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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87. El Demellawy D, Escott N, Salama S, Alowami S: Sebaceoma of the external ear canal: an unusual location. Case report and review of the literature. J Cutan Pathol; 2008 Oct;35(10):963-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sebaceous neoplasms of the external ear canal are extremely rare.
  • Only two cases of sebaceous neoplasms have been reported in the English literature, a sebaceous carcinoma and a sebaceous adenoma.
  • We highlight the differential diagnosis, particularly sebaceous carcinoma and basal cell carcinoma with sebaceous differentiation.
  • [MeSH-major] Ear Canal / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Sebaceous / pathology. Aged. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 18564279.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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88. Tsai TM, Wu YH, Yang KC, Yang CY, Tsai TH, Chan JY: Sebaceous carcinoma associated with seborrheic keratosis. J Cutan Med Surg; 2010 Sep-Oct;14(5):240-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma associated with seborrheic keratosis.
  • BACKGROUND: The association of a seborrheic keratosis with other common cutaneous neoplasms such as basal cell carcinoma and Bowen disease has been reported, but the association between a seborrheic keratotis and a malignant neoplasm with sebaceous differentiation is very unusual.
  • OBJECTIVE: We present a case of two contiguous neoplasms, a seborrheic keratosis and a sebaceous carcinoma, and discuss the possibility of malignant change in a seborrheic keratosis as an explanation for the findings.
  • Histopathologic examination revealed that the plaque was composed of two different adjacent tumors, including a central portion showing findings consistent with a sebaceous carcinoma and a peripheral part showing a seborrheic keratosis.
  • CONCLUSION: Although the association is likely to be a coincidence and probably represents a collision tumor, the possibility that the sebaceous carcinoma represents malignant degeneration of the seborrheic keratosis cannot be entirely excluded.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 20868621.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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89. Cabral ES, Auerbach A, Killian JK, Barrett TL, Cassarino DS: Distinction of benign sebaceous proliferations from sebaceous carcinomas by immunohistochemistry. Am J Dermatopathol; 2006 Dec;28(6):465-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distinction of benign sebaceous proliferations from sebaceous carcinomas by immunohistochemistry.
  • Sebaceous lesions, including sebaceous hyperplasia, sebaceomas, and sebaceous adenomas and carcinomas, are histologically distinctive adnexal proliferations with a spectrum of biological behavior ranging from benign to frankly malignant.
  • The histologic distinction between sebaceous adenomas and carcinomas may be challenging, especially in cases showing atypical features and in small or partial biopsies.
  • We studied multiple oncogenic and therapeutic related proteins by immunohistochemistry to identify differences in expression between benign and malignant sebaceous proliferations.
  • A total of 27 cases, including 9 sebaceous adenomas, 4 sebaceomas, 8 sebaceous carcinomas, and 6 cases of sebaceous hyperplasia, were examined by immunohistochemistry, with antibodies directed against Ki-67 (MIB-1), bcl-2, p53, p21WAF1, p27Kip1, c-erbB-2 (Her-2/neu), CD117 (c-kit), cyclin D1, MDM2, CD99, MLH-1, and MSH-2.
  • We found that sebaceous adenomas and sebaceomas stained like sebaceous hyperplasia did, whereas carcinomas had statistically significantly increased levels of p53 (50% versus 11%, respectively) and Ki-67 (30% versus 10%).
  • In addition, we found little or no Her-2/neu and CD117 staining, indicating that immunotherapy with Herceptin or Gleevac would likely not be useful for sebaceous carcinomas.
  • Moreover, these results show that sebaceous adenomas and carcinomas are distinct neoplasms and provide no support for the theory that all sebaceous adenomas are truly malignant.
  • [MeSH-major] Biomarkers, Tumor / analysis. Facial Neoplasms / chemistry. Sebaceous Gland Neoplasms / chemistry. Sebaceous Glands / chemistry
  • [MeSH-minor] Adenocarcinoma, Sebaceous / chemistry. Adenoma / chemistry. Adult. Aged. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p21 / analysis. Female. Humans. Hyperplasia. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / analysis. Receptor, ErbB-2 / analysis. Tumor Suppressor Protein p53 / analysis


90. Yanaba K, Nakagawa H, Takeda Y, Koyama N, Sugano K: Muir-Torre syndrome caused by partial duplication of MSH2 gene by Alu-mediated nonhomologous recombination. Br J Dermatol; 2008 Jan;158(1):150-6
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  • The surgical specimen revealed a sebaceous carcinoma.
  • Systemic evaluation for latent malignancies revealed early-stage colonic adenocarcinoma.
  • Microsatellite instability was detected in the sebaceous carcinoma, suggesting a DNA mismatch repair gene mutation.
  • Immunohistochemical analysis showed diminished MSH2 protein levels in the sebaceous carcinoma and colonic adenocarcinoma.
  • Furthermore, the present case indicates that the dermatologist plays an important role in the diagnosis of MTS and evaluation for latent malignancies.
  • [MeSH-major] Adenocarcinoma, Sebaceous / genetics. Head and Neck Neoplasms / genetics. MutS Homolog 2 Protein / genetics. Neoplastic Syndromes, Hereditary / genetics. Sebaceous Gland Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Base Sequence. Colonic Neoplasms / genetics. Gene Duplication. Humans. Male. Middle Aged. Molecular Sequence Data. Pedigree. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 17941949.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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91. Hertel V, Bozzato A, Alexiou C: [Unilateral neck mass, dysphagia and dyspnea]. HNO; 2010 Aug;58(8):818-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extraocular sebaceous carcinoma is a rare malignant tumor, arising from skin and salivary glands.
  • An important differential diagnosis in the head and neck region is metastasizing squamous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Deglutition Disorders / etiology. Dyspnea / etiology. Head and Neck Neoplasms / diagnosis. Hypopharyngeal Neoplasms / diagnosis. Sebaceous Gland Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Diagnosis, Differential. Endoscopy. Humans. Keratin-5 / analysis. Male. Pyriform Sinus / pathology. Pyriform Sinus / surgery. Surgical Flaps. Tomography, X-Ray Computed. Tracheotomy. Ultrasonography


92. Stafanous SN: The switch flap in eyelid reconstruction. Orbit; 2007 Dec;26(4):255-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: Eight cases of large full-thickness eyelid defects resulting from excision of tumours such as basal cell carcinoma (bcc), squamous cell carcinoma (scc) and sebaceous gland carcinoma (sgc) were taken for repair using the switch flap technique.
  • RESULTS: Out of the eight cases of eyelid defects, one was from squamous cell carcinoma, three were from sebaceous gland carcinoma, and four were from infiltrative basal cell carcinoma.

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  • (PMID = 18097963.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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93. Sahn RE, Lang PG: Sentinel lymph node biopsy for high-risk nonmelanoma skin cancers. Dermatol Surg; 2007 Jul;33(7):786-92; discussion 792-3
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  • OBJECTIVE: The objective was to report our experience with patients who underwent SLNB for the staging of a high-risk NMSC.
  • RESULTS: Of 13 patients, 9 had squamous cell carcinoma (SCC), 2 had sebaceous gland carcinoma, 1 had porocarcinoma, and 1 had atypical fibroxanthoma.
  • All SLNB were negative for metastatic disease, but 1 appeared to be a false-negative finding.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Squamous Cell / pathology. Sebaceous Gland Neoplasms / pathology. Sentinel Lymph Node Biopsy. Skin Neoplasms / pathology

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  • (PMID = 17598843.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. van den Bedem SP, Schutte S, van der Helm FC, Simonsz HJ: Mechanical properties and functional importance of pulley bands or 'faisseaux tendineux'. Vision Res; 2005 Sep;45(20):2710-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Exenterations were carried out on two patients with sebaceous gland carcinoma.

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  • [CommentIn] Vision Res. 2006 Sep;46(18):3036-8; author reply 3039-40 [16337667.001]
  • (PMID = 15993458.001).
  • [ISSN] 0042-6989
  • [Journal-full-title] Vision research
  • [ISO-abbreviation] Vision Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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95. Ramljak V, Sarcević B, Vrdoljak DV, Kelcec IB, Agai M, Ostović KT: Fine needle aspiration cytology in diagnosing rare breast carcinoma--two case reports. Coll Antropol; 2010 Mar;34(1):201-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytology in diagnosing rare breast carcinoma--two case reports.
  • In this paper, we are presenting the two cases of very rare tumors: breast sebaceous carcinoma, which has been described for the first time in Croatian medical literature, and pure breast squamous carcinoma.
  • First case, sebaceous carcinoma, is still quite unknown regarding its morphological characteristics and biological behavior.
  • In the second case, squamous carcinoma, also very rare, was found in a patient who previously had a number of diagnosed head and neck skin carcinomas, and was diagnosed as primary squamous breast carcinoma.
  • The second one, a 69-year-old female presented to our hospital in January 2008 with a two months history of a lump in the lower outer region of the left breast and enlarged lymph nodes in left axillary region.
  • This methodology was found important in diagnosis, but in both cases showed certain limitations in diagnosing such rare tumors.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biopsy, Fine-Needle. Breast Neoplasms / pathology. Carcinoma, Squamous Cell / pathology

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  • (PMID = 20432752.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / May-Grunwald Giemsa; T42P99266K / Methylene Blue; TDQ283MPCW / Eosine Yellowish-(YS)
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96. Nishizawa A, Nakanishi Y, Sasajima Y, Yamazaki N, Yamamoto A: Muir-torre syndrome with intriguing squamous lesions: a case report and review of the literature. Am J Dermatopathol; 2006 Feb;28(1):56-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Muir-Torre syndrome (MTS) is an autosomal, dominantly inherited disorder characterized by sebaceous neoplasms and visceral malignancies.
  • We report a 56-year-old woman who underwent resections of extraocular sebaceous carcinoma, sebaceous epithelioma, actinic keratosis, and keratoacanthoma (KA)-like squamous cell carcinoma (SCC) with venous invasion metachronously over a 9-year period.
  • Because of the mixed, unusual features of the skin lesions, and her history of endometrial and colorectal cancers that had been resected 12 years and 1 year, respectively, before the present event, a possible diagnosis of Muir-Torre syndrome was suggested.
  • This patient presented with intriguing squamous lesions including keratoacanthoma-like squamous cell carcinoma that showed venous invasion and actinic keratosis, and associated loss of hMSH2 expression, in addition to the sebaceous neoplasms typical of Muir-Torre syndrome.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Sebaceous Gland Neoplasms / pathology. Syndrome
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Cell Nucleus / metabolism. Cell Nucleus / pathology. Female. Humans. Immunohistochemistry. Keratoacanthoma / genetics. Keratoacanthoma / metabolism. Keratoacanthoma / pathology. Loss of Heterozygosity. Middle Aged. MutS Homolog 2 Protein / genetics. MutS Homolog 2 Protein / metabolism

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  • (PMID = 16456327.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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97. Ohshiro T, Tsuchida Y, Harashina T, Wakamatsu K, Yamaguchi S: Reconstruction of the levator function and conjunctiva using an inferiorly based orbital septal flap for subtotal full-thickness defects of the upper eyelid: two cases of ocular sebaceous carcinoma. Ann Plast Surg; 2006 Mar;56(3):336-9
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  • [Title] Reconstruction of the levator function and conjunctiva using an inferiorly based orbital septal flap for subtotal full-thickness defects of the upper eyelid: two cases of ocular sebaceous carcinoma.
  • In 2 cases of ocular sebaceous carcinoma, the levator function and conjunctiva were reconstructed using the inferiorly based orbital septal flap and conchal cartilage graft.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Eyelid Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Sebaceous Glands / pathology. Skin Transplantation / methods

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  • (PMID = 16508369.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Prayaga AK, Loya AC, Gottimukkala SR, Digumarti RR, Maddali LS, Challa S: Cytologic features of primary malignant tumors of skin and adnexae. Acta Cytol; 2008 Nov-Dec;52(6):702-9
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  • [Title] Cytologic features of primary malignant tumors of skin and adnexae.
  • STUDY DESIGN: Cases of primary malignant tumors of skin and adnexae diagnosed on cytology with histopathology confirmation were retrieved from case records of 1998-2005.
  • RESULTS: Thirty primary malignant tumors of skin and adnexae were analyzed.
  • Melanoma was the most common (n=12), followed by squamous cell carcinoma (SCC) (n=5).
  • There were 3 basal cell carcinomas and 2 cases each of sebaceous carcinoma, Paget's disease of the breast and lymphoma.
  • There were single cases of eccrine carcinoma, malignant trichilemmal tumor, undifferentiated carcinoma and extramedullary myeloid cell tumor.
  • CONCLUSION: Cytodiagnosis of primary malignant tumors of skin and adnexae is possible based on morphology and clinical presentation.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / pathology. Breast Neoplasms / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Cytodiagnosis. Humans. Lymphatic Metastasis. Medical Records. Melanoma / pathology. Paget's Disease, Mammary / pathology

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  • (PMID = 19068675.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Russell HC, Chadha V, Lockington D, Kemp EG: Topical mitomycin C chemotherapy in the management of ocular surface neoplasia: a 10-year review of treatment outcomes and complications. Br J Ophthalmol; 2010 Oct;94(10):1316-21
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  • METHODS: This study is a retrospective review of patients treated with topical MMC for ocular surface neoplasia, including primary acquired melanosis (PAM), melanoma, corneal-conjunctival intraepithelial neoplasia (CCIN), squamous cell carcinoma (SCC) and sebaceous gland carcinoma (SGC).
  • Data regarding diagnosis, short- and long-term outcomes, and short- and long-term complications, were recorded.
  • Overall, 26% developed recurrent disease at a mean of 13 months post treatment.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Eye Neoplasms / drug therapy. Mitomycin / administration & dosage. Sebaceous Gland Neoplasms / drug therapy

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  • (PMID = 20530655.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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100. Lanoy E, Dores GM, Madeleine MM, Toro JR, Fraumeni JF Jr, Engels EA: Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS; 2009 Jan 28;23(3):385-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • DESIGN: We linked data from population-based US AIDS and cancer registries to evaluate risk of nonkeratinocytic skin cancers (melanoma, Merkel cell carcinoma, and appendageal carcinomas, including sebaceous carcinoma) in 497 142 persons with AIDS.
  • RESULTS: From 60 months before to 60 months after AIDS onset, persons with AIDS had elevated risks of melanoma (SIR = 1.3, 95% confidence interval 1.1-1.4, n = 292 cases) and, more strongly, of Merkel cell carcinoma (SIR = 11, 95% confidence interval 6.3-17, n = 17) and sebaceous carcinoma (SIR = 8.1, 95% confidence interval 3.2-17, n = 7).
  • In contrast, the greatly increased risks for Merkel cell and sebaceous carcinoma suggest an etiologic role for immunosuppression.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / immunology. Adenocarcinoma, Sebaceous / virology. Adolescent. Adult. CD4 Lymphocyte Count. Carcinoma, Merkel Cell / epidemiology. Carcinoma, Merkel Cell / immunology. Carcinoma, Merkel Cell / virology. Child. Child, Preschool. Epidemiologic Methods. Female. Humans. Immunocompromised Host. Infant. Infant, Newborn. Male. Melanoma / epidemiology. Melanoma / immunology. Melanoma / virology. Middle Aged. United States / epidemiology. Young Adult

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  • (PMID = 19114864.001).
  • [ISSN] 1473-5571
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CP010150-08
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS89955; NLM/ PMC2728602
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