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1. Goh BK: Intraductal papillary-mucinous neoplasms and mucinous cystic neoplasms of the pancreas differentiated by ovarian-type stroma. Surgery; 2007 Apr;141(4):545-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal papillary-mucinous neoplasms and mucinous cystic neoplasms of the pancreas differentiated by ovarian-type stroma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Pancreatic Neoplasms / pathology. Stromal Cells / pathology

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  • [CommentOn] Surgery. 2006 Sep;140(3):448-53 [16934608.001]
  • (PMID = 17383536.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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2. Ito Y, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Miyauchi A: Ultrasonographically and anatomopathologically detectable node metastases in the lateral compartment as indicators of worse relapse-free survival in patients with papillary thyroid carcinoma. World J Surg; 2005 Jul;29(7):917-20
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  • [Title] Ultrasonographically and anatomopathologically detectable node metastases in the lateral compartment as indicators of worse relapse-free survival in patients with papillary thyroid carcinoma.
  • In this study, we investigated the prognostic impact of lateral node metastasis preoperatively detectable by ultrasonography (US) and metastasis diagnosed by pathology examination but not detected on preoperative US [anatomopathologically (AP)-detectable metastasis] in 560 patients with papillary carcinoma >1 cm in diameter, who underwent thyroidectomy with modified radical neck dissection at our hospital.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnostic imaging. Adenocarcinoma, Papillary / pathology. Lymph Nodes / pathology. Thyroid Neoplasms / diagnostic imaging. Thyroid Neoplasms / pathology

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  • (PMID = 15951927.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. Yoon JH, Kim EK, Hong SW, Kwak JY, Kim MJ: Sonographic features of the follicular variant of papillary thyroid carcinoma. J Ultrasound Med; 2008 Oct;27(10):1431-7
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  • [Title] Sonographic features of the follicular variant of papillary thyroid carcinoma.
  • OBJECTIVE: The purpose of this study was to evaluate the sonographic findings of the follicular variant of papillary thyroid carcinoma (FVPTC) and to assess the role of preoperative fine-needle aspiration biopsy (FNAB).
  • Malignant findings included marked hypoechogenicity, irregular or microlobulated margins, a taller-than-wide shape, and microcalcifications.
  • Thyroid nodules with a single malignant finding as described above were classified as malignant.
  • Eighteen lesions (66.7%) were correctly classified as malignant, whereas 9 (33.3%) were classified as benign on the basis of sonographic criteria.
  • Twenty-one of 24 diagnostic cytologic results (87.5%) were suspicious for papillary carcinoma (5 of 21 [20.8%]) or malignant (16 of 21 [66.7%]), whereas 3 lesions (12.5%) had benign results.
  • CONCLUSIONS: The follicular variant of papillary thyroid carcinoma tends to have relatively benign sonographic features, such as hypoechogenicity, well-defined margins, an oval shape, and no microcalcifications, but most lesions were correctly classified as malignant by both sonography and FNAB.
  • The possibility of FVPTC should be considered when thyroid nodules with a relatively benign sonographic appearance have suspicious or malignant FNAB results.
  • [MeSH-major] Adenocarcinoma, Follicular / ultrasonography. Adenocarcinoma, Papillary / ultrasonography. Thyroid Neoplasms / ultrasonography. Ultrasonography / methods
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 18809953.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Friese JL, Hara AK: AJR Teaching File: chronic nausea and vomiting with abdominal pain. AJR Am J Roentgenol; 2006 Jun;186(6 Suppl 1):S445-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Pancreas / abnormalities. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Abdominal Pain / complications. Abdominal Pain / etiology. Aged. Chronic Disease. Diagnosis, Differential. Female. Humans. Nausea / complications. Tomography, X-Ray Computed. Vomiting / complications

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  • (PMID = 16714623.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Liu YI, Shin LK, Kamaya A, Jeffrey RB: An unusual imaging and clinical presentation of papillary thyroid carcinoma. J Ultrasound Med; 2008 Aug;27(8):1241-4
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  • [Title] An unusual imaging and clinical presentation of papillary thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / secondary. Adenocarcinoma, Papillary / ultrasonography. Bone Neoplasms / secondary. Bone Neoplasms / ultrasonography. Thyroid Neoplasms / ultrasonography

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  • (PMID = 18645084.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Kim KH, Suh KS, Kang DW, Kang DY: Mutations of the BRAF gene in papillary thyroid carcinoma and in Hashimoto's thyroiditis. Pathol Int; 2005 Sep;55(9):540-5
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  • [Title] Mutations of the BRAF gene in papillary thyroid carcinoma and in Hashimoto's thyroiditis.
  • The purpose of the present study was to investigate the frequency of BRAF mutations in human papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) and to evaluate the association of the BRAF mutation with the clinicopathological features of both of these thyroid disorders.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Point Mutation. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / genetics. Thyroiditis, Autoimmune / genetics

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  • (PMID = 16143028.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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7. Jones NB, Hatzaras I, George N, Muscarella P, Ellison EC, Melvin WS, Bloomston M: Clinical factors predictive of malignant and premalignant cystic neoplasms of the pancreas: a single institution experience. HPB (Oxford); 2009 Dec;11(8):664-70
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  • [Title] Clinical factors predictive of malignant and premalignant cystic neoplasms of the pancreas: a single institution experience.
  • Invasive adenocarcinoma was identified in 35 whereas 79 had benign lesions.
  • Mucinous lesions were considered premalignant and consisted of 29 intraductal papillary mucinous neoplasms (IPMN) and 17 mucinous cystic neoplasms (MCN).
  • Size, however, was not an accurate test to determine premalignant or malignant lesions using area under the ROC curve analysis whereas CA19-9 performed the best regardless of gender or lesion location.

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  • (PMID = 20495634.001).
  • [ISSN] 1477-2574
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2799619
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8. Mazzucchelli R, Barbisan F, Santinelli A, Scarpelli M, Galosi AB, Lopez-Beltran A, Cheng L, Kirkali Z, Montironi R: Prediction of prostatic involvement by urothelial carcinoma in radical cystoprostatectomy for bladder cancer. Urology; 2009 Aug;74(2):385-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: To ascertain which variables of bladder urothelial carcinoma (UC) might be useful in predicting either UC involving the prostate (UCP) or incidental prostate adenocarcinoma in radical cystoprostatectomy specimens.
  • Stepwise discriminant analysis was used to predict UCP or incidental prostate adenocarcinoma.
  • Prostate adenocarcinoma was identified in 123 patients (49.6%).
  • Carcinoma in situ and high-grade urothelial papillary carcinoma were seen in 8 (3.2%) and 5 (2.0%) patients, respectively.
  • Discriminant analysis selected 2 variables of bladder UC (focality and previous recurrence) and correctly predicted the group in 57.7% of patients without and with prostate adenocarcinoma.
  • [MeSH-major] Carcinoma, Transitional Cell / surgery. Cystectomy. Prostatectomy. Prostatic Neoplasms / diagnosis. Urinary Bladder Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adult. Aged. Aged, 80 and over. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasms, Multiple Primary / diagnosis


9. Frey J, Shimek C, Woodmansee C, Myers E, Greer S, Liman A, Adelman C, Rasberry R: Aggressive digital papillary adenocarcinoma: a report of two diseases and review of the literature. J Am Acad Dermatol; 2009 Feb;60(2):331-9
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  • [Title] Aggressive digital papillary adenocarcinoma: a report of two diseases and review of the literature.
  • Aggressive digital papillary adenocarcinoma (ADPAca) is a rare, underreported, and often misdiagnosed malignant tumor of the sweat glands most commonly occurring in males in their fifties to seventies.
  • These cases highlight both the importance of high clinical suspicion of digital tumors, even in children, enabling prompt diagnosis and treatment and also emphasize the metastatic potential of the tumor and the need for aggressive treatment and close long-term follow-up.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / surgery. Fingers. Sweat Gland Neoplasms / pathology. Sweat Gland Neoplasms / surgery

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  • (PMID = 18819728.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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10. Sai JK, Suyama M, Kubokawa Y, Watanabe S, Maehara T: Pancreatic-duct-lavage cytology in candidates for surgical resection of branch-duct intraductal papillary mucinous neoplasm of the pancreas: should the International Consensus Guidelines be revised? Gastrointest Endosc; 2009 Mar;69(3 Pt 1):434-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreatic-duct-lavage cytology in candidates for surgical resection of branch-duct intraductal papillary mucinous neoplasm of the pancreas: should the International Consensus Guidelines be revised?
  • BACKGROUND: The International Consensus Guidelines are helpful for the management of branch-duct intraductal papillary mucinous neoplasms (IPMNs), because they allow us to exclude malignancy.
  • However, it is not possible to predict malignancy with certainty, and further preoperative differentiation between benign and malignant IPMNs is required to avoid the false-positive results.
  • OBJECTIVE: To examine the usefulness of pancreatic-duct-lavage cytology by using an originally designed double-lumen catheter for discriminating benign and malignant IPMNs of the branch-duct type in candidates for surgical resection based on the International Consensus Guidelines.
  • MAIN OUTCOME MEASUREMENTS: The sensitivity and specificity of pancreatic-duct-lavage cytology for discriminating benign from malignant IPMNs.
  • The sensitivity, specificity, positive predictive value, and negative predictive value of the cytologic diagnosis were 78%, 93%, 88%, and 88%, respectively.
  • CONCLUSIONS: Pancreatic-duct-lavage cytology can improve differentiation between benign and malignant IPMNs of the branch-duct type in candidates for surgical resection based on the International Consensus Guidelines.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Pancreatic Ducts. Pancreatic Neoplasms / pathology. Practice Guidelines as Topic

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  • [CommentIn] Gastrointest Endosc. 2009 Mar;69(3 Pt 1):441-3 [19231485.001]
  • (PMID = 18684453.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Goonetilleke KS, Siriwardena AK: Current status of gene expression profiling of pancreatic cancer. Int J Surg; 2008 Feb;6(1):81-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Additionally the outcome of surgery for pancreatic cancer remains poor, largely due to late clinical presentation of most cases, and early detection, particularly in high risk groups, such as those with chronic pancreatitis, Intraductal papillary mucinous cystadenoma (IPMN) would enable earlier surgical intervention and improved survival.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Gene Expression Profiling. Pancreatic Neoplasms / diagnosis

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  • (PMID = 18359465.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gastric Mucins; 0 / apomucin
  • [Number-of-references] 26
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12. Mercante G, Frasoldati A, Pedroni C, Formisano D, Renna L, Piana S, Gardini G, Valcavi R, Barbieri V: Prognostic factors affecting neck lymph node recurrence and distant metastasis in papillary microcarcinoma of the thyroid: results of a study in 445 patients. Thyroid; 2009 Jul;19(7):707-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors affecting neck lymph node recurrence and distant metastasis in papillary microcarcinoma of the thyroid: results of a study in 445 patients.
  • BACKGROUND: The management of thyroid papillary microcarcinoma (PMC) is controversial.
  • We investigated the clinical course and prognostic factors for disease recurrence and distant metastasis in 445 patients with PMC.
  • Seventeen (3.8%) patients had recurrence or persistence of disease: neck recurrence (NR) in 12 (2.7%), distant metastasis (DM) in four (0.9%), NR + DM in one (0.2%).
  • One patient (0.2%) died of the disease.
  • Patients not showing these features, who were treated with loboisthmusectomy only, never experienced disease recurrence.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Carcinoma, Papillary / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 19348581.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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13. Yamashita R, Yamaguchi R, Yuen K, Niwakawa M, Tobisu K: Urothelial carcinoma (clear cell variant) diagnosed with useful immunohistochemistry stain. Int J Urol; 2006 Nov;13(11):1448-50
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  • On evaluation, a papillary pedunculated tumor was detected in the left wall of the urinary bladder.
  • The pathological diagnosis was difficult due to diffuse clear cell appearance.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Immunohistochemistry / methods. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Keratin-7 / analysis. Male. Reproducibility of Results. Sensitivity and Specificity. Urothelium / chemistry. Urothelium / pathology

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  • (PMID = 17083402.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Keratin-7
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14. Gorin DS, Kriger AG, Kochatkov AV: [Intraductal papillary-mucinous tumor]. Khirurgiia (Mosk); 2010;(9):81-7
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  • [Title] [Intraductal papillary-mucinous tumor].
  • [MeSH-major] Adenocarcinoma, Mucinous. Adenocarcinoma, Papillary. Pancreatectomy / methods. Pancreatic Cyst / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms

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  • (PMID = 21510444.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] Journal Article; Review
  • [Publication-country] Russia (Federation)
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15. Rapa I, Volante M, Cappia S, Rosas R, Scagliotti GV, Papotti M: Cathepsin K is selectively expressed in the stroma of lung adenocarcinoma but not in bronchioloalveolar carcinoma. A useful marker of invasive growth. Am J Clin Pathol; 2006 Jun;125(6):847-54
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  • [Title] Cathepsin K is selectively expressed in the stroma of lung adenocarcinoma but not in bronchioloalveolar carcinoma. A useful marker of invasive growth.
  • Lung bronchioalveolar carcinomas (BACs) are noninvasive tumors showing lepidic growth and excellent prognosis, whereas all the other variants of adenocarcinoma are invasive tumors with a worse prognosis.
  • The identification of minimal invasive foci in adenocarcinoma, therefore, is of prognostic relevance.
  • A series of 68 pulmonary tumors, including 40 acinar/papillary adenocarcinomas, 18 adenocarcinomas of the mixed subtype, and 10 BACs was tested by immunohistochemical analysis for cathepsin K expression, a proteinase involved in bone and extracellular matrix remodeling.
  • Cathepsin K was produced by epithelial tumor cells in most invasive adenocarcinomas and, interestingly, by macrophages and fibroblasts in the stroma of invasive adenocarcinomas but not of BACs (P < .001).
  • Our findings suggest pathogenetic implications of cathepsin K in the mechanisms of tumor invasiveness in lung carcinoma; in addition, cathepsin K immunodetection may be a valuable adjunct in the correct classification of pulmonary adenocarcinomas, especially in small sclerosing BACs and mixed adenocarcinoma subtypes with minimal infiltrative growth.
  • [MeSH-major] Adenocarcinoma / enzymology. Adenocarcinoma, Bronchiolo-Alveolar / enzymology. Cathepsins / metabolism. Lung Neoplasms / enzymology

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  • (PMID = 16690483.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.- / Cathepsins; EC 3.4.22.38 / CTSK protein, human; EC 3.4.22.38 / Cathepsin K
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16. Idowu MO, Rosenblum MK, Wei XJ, Edgar MA, Soslow RA: Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct--a comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein. Am J Surg Pathol; 2008 May;32(5):710-8
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  • We reviewed the morphologic and immunohistochemical features of 5 extra-axial ependymomas occurring in adults, 1 arising in an infantile sacrococcygeal teratoma, and a control group of 10 central nervous system (CNS) ependymomas in adults.
  • We observed that both the CNS and adult extra-axial ependymomas expressed GFAP diffusely, whereas only 9 stage III, high-grade ovarian serous papillary carcinomas stained with GFAP (2 strongly and diffusely and 7 exhibiting focally weak expression).
  • The morphologic and immunophenotypic differences between extra-axial and CNS ependymomas suggest that they derive from distinct precursors and/or differentiate along distinct pathways.
  • The differential diagnosis of extra-axial ependymomas is extensive, and GFAP expression in primary ovarian serous carcinomas, although rare, could theoretically contribute to diagnostic difficulties.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Central Nervous System Neoplasms / metabolism. Ependymoma / metabolism. Glial Fibrillary Acidic Protein / metabolism. Ovarian Neoplasms / metabolism

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  • (PMID = 18360284.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein
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17. Mirarchi M, De Raffele E, Lega S, Calculli L, Vaccari S, Cola B: [Synchronous adenocarcinoma of the sigmoid colon and multifocal intraductal papillary mucinous neoplasm of the pancreas in an elderly patient]. Chir Ital; 2009 May-Jun;61(3):357-67
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  • [Title] [Synchronous adenocarcinoma of the sigmoid colon and multifocal intraductal papillary mucinous neoplasm of the pancreas in an elderly patient].
  • [Transliterated title] Adenocarcinoma del colon e neoplasia papillare intraduttale mucinosa multifocale sincrona del pancreas in un paziente anziano: caso clinico e revisione della letteratura.
  • Intraductal papillary mucinous neoplasms are a well-recognized pathologic entity of the pancreas that is being reported with increasing frequency.
  • A 78-year-old man presented with rectal bleeding which led to the diagnosis of a stenosing adenocarcinoma of the sigmoid colon.
  • No metastatic lesions were present but a 30 mm intraductal papillary mucinous neoplasm with mural nodules was detected in the uncinate process of the pancreas.
  • Histology showed a combined-type intraductal papillary mucinous neoplasm with foci of non-invasive carcinoma.
  • The co-existence of a potentially malignant pancreatic tumour with an extra-pancreatic overt malignancy in elderly patients poses difficulties in the attempt to cure the patient with minimal morbidity.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Carcinoma, Pancreatic Ductal / pathology. Neoplasms, Multiple Primary / pathology. Pancreatic Neoplasms / pathology. Sigmoid Neoplasms / pathology

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  • (PMID = 19694240.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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18. Li G, Gentil-Perret A, Lambert C, Genin C, Tostain J: S100A1 and KIT gene expressions in common subtypes of renal tumours. Eur J Surg Oncol; 2005 Apr;31(3):299-303
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  • METHODS: Fifty-five tissue samples (15 clear cell RCCs, 15 papillary RCCs, 7 chromophobe RCCs, 8 oncocytomas and 10 normal renal tissues) were studied The gene expressions of S100A1 and KIT were analysed by one-step RT-PCR by using the specific primers.
  • RESULTS: S100A1 was expressed in 2/15 clear cell RCCs, 11/15 papillary RCCs, 7/8 oncocytomas and in 0/7 chromophobe RCCs.
  • KIT gene was expressed in 6/7 chromophobe RCCs and 7/8 oncocytomas while 0/15 clear cell RCCs and 1/15 papillary RCCs expressed kit gene.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / chemistry. Adenoma, Oxyphilic / chemistry. Carcinoma, Papillary / chemistry. Carcinoma, Renal Cell / chemistry. Cell Line, Tumor. Humans. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15780567.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 146909-89-9 / S100A11 protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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19. Campisi A, Brancatelli G, Vullierme MP, Levy P, Ruszniewski P, Vilgrain V: Are pancreatic calcifications specific for the diagnosis of chronic pancreatitis? A multidetector-row CT analysis. Clin Radiol; 2009 Sep;64(9):903-11
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  • [Title] Are pancreatic calcifications specific for the diagnosis of chronic pancreatitis? A multidetector-row CT analysis.
  • AIM: To retrospectively establish the most frequently encountered diagnoses in patients with pancreatic calcifications and to investigate whether the association of certain findings could be helpful for diagnosis.
  • RESULTS: Patients had chronic pancreatitis (n=70), neuroendocrine tumours (n=14), intraductal papillary mucinous neoplasm (n=11), pancreatic adenocarcinoma (n=4), serous cystadenoma (n=4).
  • Four CT findings had a specificity of over 60% for the diagnosis of chronic pancreatitis: parenchymal calcifications, intraductal calcifications, parenchymal atrophy, and cystic lesions.
  • When at least three of these four criteria were present, a specificity of 79% for the diagnosis of chronic pancreatitis was achieved.
  • The presence of a combination of CT findings can suggest chronic pancreatitis and be helpful in diagnosis.

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  • [ErratumIn] Clin Radiol. 2009 Nov;64(11):1139. Ruzniewski, P [corrected to Ruszniewski, P]
  • (PMID = 19664481.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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20. Ohike N, Sato M, Hisayuki T, Imataka H, Sato S, Wada Y, Saito K, Takahashi M, Tajiri T, Kunimura T, Morohoshi T: Immunohistochemical analysis of nestin and c-kit and their significance in pancreatic tumors. Pathol Int; 2007 Sep;57(9):589-93
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  • Immunohistochemistry was done for 99 surgically resected pancreatic tumor specimens, including 20 ductal adenocarcinoma (DAC), two undifferentiated carcinomas (UC), 31 intraductal papillary-mucinous neoplasms (IPMN), six mucinous cystic neoplasms (MCN), five serous cystadenomas (SCA), six acinar cell carcinomas, two pancreatoblastoma (PB), eight solid-pseudopapillary neoplasms (SPN), and 19 endocrine neoplasms (EN).
  • These indicate that expression of two stem cell markers is different by tumor type, but the utility of judging direction or degree of differentiation and malignant grade on the basis of their expression status is suggested.

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  • (PMID = 17685930.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / Nestin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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21. Ridolfini MP, Gourgiotis S, Alfieri S, Di Miceli D, Rotondi F, Limongelli F, Quero G, Larghi A, Cazzato MT, Martella N, Doglietto GB: [Presentation, treatment and prognosis of intraductal papillary mucinous neoplasm]. Ann Ital Chir; 2007 Jul-Aug;78(4):257-64
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  • [Title] [Presentation, treatment and prognosis of intraductal papillary mucinous neoplasm].
  • [Transliterated title] Aspetti clinici, trattamento e prognosi della neoplasia papillare intraduttale mucosecernente.
  • Intraductal papillary mucinous neoplasms (IPMNs) are rare tumours rising from the pancreatic duct epithelium.
  • They are characterized by intraductal papillary growth and thick mucin secretion; mucin fills the Wirsung and/or branch pancreatic ducts and may cause ductal dilatation.
  • Most branch type IPMNs are benign, while the other two types are frequently malignant.
  • Recent advances in diagnostic imaging have led to an increased frequency of diagnosis of IPMNs, but the clinical features of them can range broadly from benign, borderline, and malignant non-invasive to invasive lesions, and their management has not yet been clearly defined.
  • Endoscopic retrograde cholangiopancreatography (ERCP), endoscopic ultrasonography (EUS), intraductal ultrasonography, and magnetic resonance cholangiopancreatography (MRCP) are the most valuable imaging techniques for diagnosis of these lesions.
  • Prognosis is excellent after complete resection of benign and non-invasive malignant IPMNs.
  • [MeSH-major] Adenocarcinoma, Mucinous. Carcinoma, Pancreatic Ductal. Pancreatic Neoplasms
  • [MeSH-minor] Aged. Diagnosis, Differential. Dilatation, Pathologic / etiology. Female. Humans. Male. Middle Aged. Pancreatic Ducts. Prognosis

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  • (PMID = 17990599.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 75
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22. Matsuoka T, Sugi K, Matsuda E, Okabe K, Hirazawa K, Azuma T: [Mycobacterium avium complex (MAC) infection needed differential diagnosis of the recurrence after surgery for double lung cancer; report of a case]. Kyobu Geka; 2007 Dec;60(13):1200-3
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  • [Title] [Mycobacterium avium complex (MAC) infection needed differential diagnosis of the recurrence after surgery for double lung cancer; report of a case].
  • A 62-year-old woman had undergone video-assisted thoracic surgery (VATS) -right upper lobectomy and right S8 segmentectomy for double lung cancers (papillary adenocarcinoma and bronchioloalveoler carcinoma, stage IA).
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / surgery. Lung Neoplasms / diagnosis. Lung Neoplasms / surgery. Mycobacterium avium-intracellulare Infection / diagnosis. Neoplasms, Multiple Primary. Tuberculosis, Pulmonary / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 18078091.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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23. Naitoh Y, Ban S, Tsuchiya C, Sugiura Y, Shimizu M: Multicentric invasive carcinomas derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreas: report of a case. Virchows Arch; 2007 Apr;450(4):487-90
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  • [Title] Multicentric invasive carcinomas derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreas: report of a case.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Pancreatic Neoplasms / pathology

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  • [Cites] Virchows Arch. 2005 Nov;447(5):794-9 [16088402.001]
  • [Cites] Am J Surg Pathol. 2006 Dec;30(12):1561-9 [17122512.001]
  • [Cites] Am J Surg Pathol. 2001 Jul;25(7):942-8 [11420467.001]
  • [Cites] J Pathol. 2002 Aug;197(5):632-7 [12210083.001]
  • [Cites] Am J Surg Pathol. 2000 Oct;24(10):1372-7 [11023098.001]
  • [Cites] Pancreatology. 2002;2(5):484-90 [12378117.001]
  • [Cites] J Pathol. 2002 Jun;197(2):201-10 [12015744.001]
  • (PMID = 17333261.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MUC1 protein, human; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucin-6; 0 / Mucins
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24. Giorgadze TA, Baloch ZW, Pasha T, Zhang PJ, Livolsi VA: Lymphatic and blood vessel density in the follicular patterned lesions of thyroid. Mod Pathol; 2005 Nov;18(11):1424-31
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  • The histologic distinction of follicular patterned lesions of thyroid, that is follicular adenoma, follicular carcinoma, and the follicular variant of papillary thyroid carcinoma can be extremely difficult.
  • The differential diagnostic criteria regarding nuclear features of papillary thyroid carcinoma are subjective, resulting in high interobserver variability.
  • Although papillary thyroid carcinoma metastasizes mainly via lymphatic vessels, whereas follicular carcinoma spreads mostly hematogenously, there are no data regarding utility of objective quantitative criteria such as lymphatic and general blood vessel density for the differential diagnosis of these lesions.
  • In this study, 35 follicular patterned lesions of thyroid (14 follicular adenomas, 10 follicular carcinomas, and 11 of the follicular variant of papillary thyroid carcinomas) were evaluated immunohistochemically.
  • There were no significant differences in the intra- and/or peritumoral general vessel densities, and peritumoral lymphatic vessel densities among follicular adenoma, follicular carcinoma and the follicular variant of papillary thyroid carcinoma.
  • In contrast, the intratumoral lymphatic vessel density was significantly higher in the follicular variant of papillary thyroid carcinoma than in either follicular adenoma or follicular carcinoma (34.63, 15.04, and 0.11 respectively; P<0.0001).
  • The results of the study show that intratumoral lymphatic vessel density may serve as a useful tool in the differential diagnosis of follicular patterned lesions of thyroid.
  • [MeSH-major] Biomarkers, Tumor / analysis. Lymphangiogenesis / physiology. Neovascularization, Pathologic / pathology. Thyroid Neoplasms / blood supply. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenoma / diagnosis. Antibodies, Monoclonal. Antibodies, Monoclonal, Murine-Derived. Antigens, CD31. Carcinoma, Papillary / diagnosis. Diagnosis, Differential. Humans. Immunohistochemistry

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  • [Copyright] Modern Pathology (2005) 18, 1424-1431. doi:10.1038/modpathol.3800452; published online 27 May 2005.
  • (PMID = 15920537.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD31; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
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25. Westphalen AC, Coakley FV, Joe BN: Radiological reasoning: 88-year-old man with abdominal pain and dilated biliary tree and pancreatic duct. AJR Am J Roentgenol; 2010 Jun;194(6 Suppl):S46-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Abdominal Pain / diagnosis. Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Pancreatic Neoplasms / diagnosis. Pneumonia / diagnosis
  • [MeSH-minor] Aged, 80 and over. Ampulla of Vater / pathology. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Diagnosis, Differential. Dilatation, Pathologic. Endoscopy, Gastrointestinal. Endosonography. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 20489116.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Conference; Journal Article
  • [Publication-country] United States
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26. Ozmen V, Asoglu O, Karanlik H, Cabioglu N, Kecer M, Bakkaloglu H: Primary ovarian cancer presenting with axillary lymph node metastases: a report of two cases. Acta Chir Belg; 2007 Jan-Feb;107(1):75-7
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  • Histopathologic examination showed ovarian epithelial serous papillary adenocarcinoma metastases to axillary lymph node and the rectum.
  • She was treated surgically and by systemic chemotherapy with a diagnosis of stage IIIA epithelial ovarian cancer two years previously.
  • Complete axillary lymph node dissection was performed and metastases of ovarian papillary adenocarcinoma were found in 11 of the 30 lymph nodes.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Lymphatic Metastasis. Ovarian Neoplasms / pathology

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  • (PMID = 17405606.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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27. Carrizo F, Luna MA: Thyroid transcription factor-1 expression in thyroid-like nasopharyngeal papillary adenocarcinoma: report of 2 cases. Ann Diagn Pathol; 2005 Aug;9(4):189-92
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  • [Title] Thyroid transcription factor-1 expression in thyroid-like nasopharyngeal papillary adenocarcinoma: report of 2 cases.
  • We present the cases of 2 pediatric patients with low-grade nasopharyngeal papillary adenocarcinoma with features suggestive of thyroid origin.
  • The patients remain free of disease 2 and 15 years after treatment, with no evidence of lesions in the thyroid or elsewhere.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. Adenocarcinoma, Papillary / pathology. Nasopharyngeal Neoplasms / metabolism. Nasopharyngeal Neoplasms / pathology. Nuclear Proteins / biosynthesis. Transcription Factors / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Diagnosis, Differential. Humans. Immunohistochemistry. Keratin-7. Keratins / biosynthesis. Male

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  • (PMID = 16084450.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1; 68238-35-7 / Keratins
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28. Yeh TS, Tseng JH, Liu NJ, Chen TC, Jan YY, Chen MF: Significance of cellular distribution of ezrin in pancreatic cystic neoplasms and ductal adenocarcinoma. Arch Surg; 2005 Dec;140(12):1184-90
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  • [Title] Significance of cellular distribution of ezrin in pancreatic cystic neoplasms and ductal adenocarcinoma.
  • HYPOTHESIS: Pancreatic cystic neoplasms and ductal adenocarcinoma manifest diverse clinical features and prognoses, which might be related to cellular distribution of ezrin modulated through various trophic molecules.
  • PATIENTS AND METHODS: Patients with solid pseudopapillary tumor (SPT) (n = 12), mucinous cystic neoplasm (MCN) (n = 18), intraductal papillary mucinous tumor (IPMT) (n = 18), and ductal adenocarcinoma (PA) (n = 73) of the pancreas were studied.
  • RESULTS: None of 12 SPTs displayed synchronous expression of EGF and EGFR, while all 3 malignant SPTs displayed membranous ezrin expression.
  • One of 18 MCNs displayed synchronous expression of EGF and EGFR, while 4 of 6 borderline malignant and 8 of 8 malignant MCNs displayed membranous ezrin expression.
  • Two of 4 borderline malignant and 11 of 11 malignant IPMTs displayed synchronous expression of EGF and EGFR, and all borderline malignant and malignant IPMTs displayed membranous ezrin expression.
  • CONCLUSIONS: Membranous translocation of ezrin might play a role during malignant transformation of SPT, MCN, IPMT, and PA, which are either dependent on (IPMT and PA) or independent of (SPT and MCN) the EGF-EGFR pathway.
  • [MeSH-major] Adenocarcinoma, Mucinous / chemistry. Carcinoma, Pancreatic Ductal / chemistry. Pancreatic Neoplasms / chemistry. Phosphoproteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Cytoskeletal Proteins. Disease Progression. Epidermal Growth Factor / metabolism. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Multivariate Analysis. Prognosis. Proportional Hazards Models. RNA, Messenger / chemistry. Receptor, Epidermal Growth Factor / metabolism. Retrospective Studies. Reverse Transcriptase Polymerase Chain Reaction. Survival Rate

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  • (PMID = 16365240.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Phosphoproteins; 0 / RNA, Messenger; 0 / ezrin; 62229-50-9 / Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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29. Nishimura R, Mogami H, Teramoto N, Tanada M, Kurita A: Inflammatory pseudotumor of the liver in a patient with early gastric cancer: CT-histopathological correlation. Jpn J Clin Oncol; 2005 Apr;35(4):218-20
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  • The gastric cancer was a papillary adenocarcinoma limited to the mucosa.
  • The CT findings of delayed peripheral rim-like or septal enhancement of the hepatic tumor may be a specific finding of IPT.
  • [MeSH-major] Adenocarcinoma, Papillary / complications. Granuloma, Plasma Cell / pathology. Granuloma, Plasma Cell / radiography. Liver Diseases / pathology. Liver Diseases / radiography. Stomach Neoplasms / complications. Tomography, X-Ray Computed


30. Acikalin MF, Ozalp S, Yalcin OT, Peker B: Mixed serous and endometrioid carcinoma of the fallopian tube: a case report with literature review. Eur J Gynaecol Oncol; 2005;26(3):342-4
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  • Malignant neoplasms of the fallopian tube are the rarest of the gynecologic cancers.
  • Papillary serous adenocarcinoma appears to be the most common histologic type.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Endometrioid / pathology. Cystadenocarcinoma, Serous / pathology. Fallopian Tube Neoplasms / pathology. Mixed Tumor, Malignant / pathology

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  • (PMID = 15991543.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
  • [Number-of-references] 13
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31. Mangrulkar VH, Gould ES, Miller F: Digital papillary adenocarcinoma: a case report. Hand Surg; 2006;11(1-2):51-3
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  • [Title] Digital papillary adenocarcinoma: a case report.
  • Digital papillary adenocarcinoma (DPAc) is a relatively rare neoplasm arising from the sweat glands with a predilection for the hand.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Fingers. Sweat Gland Neoplasms / pathology

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  • (PMID = 17080529.001).
  • [ISSN] 0218-8104
  • [Journal-full-title] Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand
  • [ISO-abbreviation] Hand Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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32. Furlan JC, Bedard YC, Rosen IB: Significance of tumor capsular invasion in well-differentiated thyroid carcinomas. Am Surg; 2007 May;73(5):484-91
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  • This study examines the influence of tumor capsular invasion on the biological behavior of papillary (PTC) and follicular thyroid carcinoma (FTC) and the prognosis of surgically treated patients.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / therapy. Carcinoma, Papillary / pathology. Carcinoma, Papillary / therapy. Thyroid Neoplasms / pathology. Thyroid Neoplasms / therapy

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  • (PMID = 17521005.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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33. Agrawal AR, Nair N: Unusual metastasis of poorly differentiated thyroid carcinoma to the masticator space. Clin Nucl Med; 2007 Jul;32(7):516-8
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  • Metastatic disease to the masticator space and to the jaws is a rare event.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / secondary. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / secondary. Stomatognathic Diseases / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 17581333.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Iqbal FR, Sani A, Gendeh BS, Aireen I: Triple primary cancers of the larynx, lung and thyroid presenting in one patient. Med J Malaysia; 2008 Dec;63(5):417-8
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  • Patients with multiple malignant primary tumours are often described, based on their chronology of presentation, as simultaneous, synchronous or metachronous tumours.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Papillary / diagnosis. Carcinoma, Squamous Cell / diagnosis. Laryngeal Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 19803306.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Malaysia
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35. Amin MB: Selected other problematic testicular and paratesticular lesions: rete testis neoplasms and pseudotumors, mesothelial lesions and secondary tumors. Mod Pathol; 2005 Feb;18 Suppl 2:S131-45
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  • The proximity and, in some instances, communication between several structures in the testis and paratestis (rete testis, epididymis, mesothelium, vestigial epithelium and paratesticular soft tissue) result in a plethora of interesting tumors and tumor-like lesions that together pose a formidable diagnostic challenge both because of their morphologic overlap and rarity.
  • This review provides an overview of the pathology of nonmesenchymal paratesticular neoplasms and pseudotumors with a focus on the approach to tubulopapillary neoplasms for which diagnostic considerations may include carcinoma of the rete testis, malignant mesothelioma, ovarian-type epithelial tumors, epididymal carcinoma and metastatic carcinomas.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenomatoid Tumor / metabolism. Adenomatoid Tumor / pathology. Algorithms. Biomarkers, Tumor / analysis. Cystadenocarcinoma, Papillary / metabolism. Cystadenocarcinoma, Papillary / pathology. Cystadenocarcinoma, Serous / metabolism. Cystadenocarcinoma, Serous / pathology. Diagnosis, Differential. Epithelium / chemistry. Epithelium / pathology. Humans. Hyperplasia. Immunohistochemistry. Male. Mesothelioma / metabolism. Mesothelioma / pathology. Rete Testis / chemistry. Rete Testis / pathology

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  • (PMID = 15502808.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 48
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36. Bussom S, Saif MW: Intraductal papillary mucinous neoplasia (IPMN). Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010. JOP; 2010;11(2):131-4
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  • [Title] Intraductal papillary mucinous neoplasia (IPMN). Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010.
  • The diagnosis and treatment of intraductal papillary mucinous tumors (IPMN) of the pancreas has evolved over the last decade.
  • IPMN is a disease of the ductal epithelium and represent a spectrum of disease, ranging from benign to malignant lesions, making the early detection and characterization of these lesions important.
  • As with villous adenomas of the colon, not all IPMNs will develop into adenocarcinoma.
  • Definitive management is surgical resection for appropriate candidates, as benign lesions harbor malignant potential.
  • Given these controversies, novel methods are needed to help in detecting and classifying IPMNs' malignant potential so that appropriate treatment can be administered.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / classification. Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Carcinoma, Papillary / classification. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Congresses as Topic. Cyst Fluid / chemistry. Cytokines / analysis. Early Detection of Cancer / methods. Enzyme-Linked Immunosorbent Assay. Gastrointestinal Neoplasms / diagnosis. Humans. Models, Biological. Neoplasm Staging / methods

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  • (PMID = 20208320.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Cytokines
  • [Number-of-references] 26
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37. Alexandrescu DT, O'Boyle K, Feliz A, Fueg A, Wiernik PH: Metastatic solid-pseudopapillary tumour of the pancreas: clinico-biological correlates and management. Clin Oncol (R Coll Radiol); 2005 Aug;17(5):358-63
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  • Pathological, genetic and molecular features distinguish solid-pseudopapillary tumours from pancreatic ductal adenocarcinoma.
  • Patients with localised disease are usually cured by surgery.
  • [MeSH-major] Carcinoma, Papillary / surgery. Pancreatic Neoplasms / surgery

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  • (PMID = 16097567.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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38. Ishibashi H, Niikawa H, Ishida I, Hosaka Y, Minowa M, Sado T, Tabata T, Okada Y, Suzuki S, Matsumura Y, Kondo T, Ono S: [Primary lung cancer incidentally diagnosed in lung biopsy for diffuse pulmonary disease]. Kyobu Geka; 2005 Aug;58(9):813-7
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  • [Title] [Primary lung cancer incidentally diagnosed in lung biopsy for diffuse pulmonary disease].
  • We here presented 2 cases of interstitial pneumonia with lung adenocarcinoma incidentally diagnosed by partially resected lung for diffuse pulmonary disease.
  • Video-assisted thoracoscopic lung biopsy was performed and was diagnosed as diffuse spreading well differentiated adenocarcinoma.
  • Video-assisted thoracoscopic lung biopsy was performed and was diagnosed as pulmonary fibrosis with papillary adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Lung / pathology. Lung Diseases, Interstitial / pathology. Lung Neoplasms / diagnosis. Thoracic Surgery, Video-Assisted


39. Nasr MR, Mukhopadhyay S, Zhang S, Katzenstein AL: Absence of the BRAF mutation in HBME1+ and CK19+ atypical cell clusters in Hashimoto thyroiditis: supportive evidence against preneoplastic change. Am J Clin Pathol; 2009 Dec;132(6):906-12
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  • An association between Hashimoto thyroiditis and papillary thyroid carcinoma has been postulated for decades.
  • We undertook this study to identify potential precursors of papillary thyroid carcinoma in Hashimoto thyroiditis using a combination of morphologic, immunohistochemical, and molecular techniques.
  • The minute size (<1 mm) of the clusters and the incomplete nuclear changes precluded a diagnosis of papillary microcarcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Hashimoto Disease / genetics. Mutation. Precancerous Conditions / genetics. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / metabolism. DNA Mutational Analysis. DNA, Neoplasm / analysis. Diagnosis, Differential. Humans. Keratin-19 / metabolism

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  • [CommentIn] Am J Clin Pathol. 2010 Jul;134(1):169-70 [20551283.001]
  • (PMID = 19926583.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / HBME-1 antigen; 0 / Keratin-19; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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40. Hansen EK, Krieg RM, Azar RJ, Jablons DM, Jahan TM, Zaloudek CJ: Unusual thoracic problems in patients with malignancies: case 3. Carcinoid tumor of the thymus. J Clin Oncol; 2005 Apr 20;23(12):2859-61
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  • [Title] Unusual thoracic problems in patients with malignancies: case 3. Carcinoid tumor of the thymus.

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  • (PMID = 15838001.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA093708-01A3; United States / NCI NIH HHS / CA / R01 CA093708; United States / NCI NIH HHS / CA / R01 CA093708-01A3
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Lazăr D, Tăban S, Sporea I, Dema A, Cornianu M, Lazăr E, Goldiş A, Vernic C: Gastric cancer: correlation between clinicopathological factors and survival of patients. II. Rom J Morphol Embryol; 2009;50(2):185-94
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  • The analysis of the potential prognosis factors has included in this study parameters concerning the patient (sex, age), as well as parameters related with the tumor (macroscopic aspect of the tumor according to the Borrman's classification, histological type according to the WHO and Lauren's classifications, degree of tumor differentiation, tumor location, stage of disease, pT and pM parameters according to the TNM classification of AJCC/UICC).
  • We have identified five papillary adenocarcinomas (8.2%), 28 tubular adenocarcinomas (46%), 17 "signet-ring" cell carcinomas (27.8%), eight mucinous adenocarcinomas (13.1%), and three undifferentiated or anaplastic carcinomas.

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  • (PMID = 19434309.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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42. Tsuzuki T, Ninomiya H, Natori Y, Ishikawa Y: Coalescent pleural malignant mesothelioma and adenocarcinoma of the lung, involving only minor asbestos exposure. Pathol Int; 2008 Jul;58(7):451-5
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  • [Title] Coalescent pleural malignant mesothelioma and adenocarcinoma of the lung, involving only minor asbestos exposure.
  • Coexistence of pulmonary adenocarcinoma and pleural malignant mesothelioma is extremely rare, although both are asbestos-related.
  • Herein is presented a rare case of coalescent lung tumor made up of a malignant mesothelioma and a pulmonary adenocarcinoma in a 62-year-old Japanese man, a high-school teacher with only minor asbestos exposure.
  • Preoperative diagnosis of adenocarcinoma was made on transbronchial biopsy.
  • They were confirmed to be malignant mesothelioma on histopathology of paraffin section.
  • The major part contained papillary proliferation of hobnail and columnar cells.
  • The former was positive for adenocarcinoma markers such as CEA, Ber-EP4, PE-10, thyroid transcription factor-1 and Napsin A, and negative for mesothelial markers including calretinin, D2-40, WT-1 and HBME, while the latter was the opposite, resulting in a diagnosis of coalescing malignant mesothelioma and adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Asbestos / adverse effects. Lung Neoplasms / pathology. Mesothelioma / pathology. Neoplasms, Multiple Primary / pathology. Pleural Neoplasms / pathology


43. Retter J, Dinter D, Bersch C, Singer MV, Löhr M: Acute recurrent pancreatitis curtaining an intraductal papillary mucinous tumor of the pancreas. J Gastrointestin Liver Dis; 2007 Dec;16(4):445-7
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  • [Title] Acute recurrent pancreatitis curtaining an intraductal papillary mucinous tumor of the pancreas.
  • Intraductal papillary mucinous tumor (IPMN) of the pancreas is a rare pancreatic tumor characterized by intraductal proliferation of mucin producing cells with hypersecretion of mucin that leads to cystic dilatation of the involved ducts.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Carcinoma, Pancreatic Ductal / complications. Carcinoma, Papillary / complications. Pancreatic Neoplasms / complications. Pancreatitis, Acute Necrotizing / etiology
  • [MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Pancreatectomy

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  • (PMID = 18193131.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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44. Romanchishen AF, Kuz'michev AS, Bogatikov AA, Morozova EB, Chukhlovin AB, Totolian AA: [Clinical significance of functional variants of matrix metalloproteinase genes in thyroid cancer]. Vestn Khir Im I I Grek; 2009;168(1):57-60
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  • A reliably decreased frequency of hyperactive genotype MMP-1 2G was detected in a group of women with metastatic forms of papillary cancer as compared with patients without metastases.
  • It was shown that MMP genes could be a substantial factor of slowing down the rate of malignant growth and invasive properties of cancer of the thyroid gland.
  • [MeSH-major] Adenocarcinoma, Papillary / enzymology. DNA, Neoplasm / genetics. Gene Expression Regulation, Neoplastic. Genetic Variation. Matrix Metalloproteinase 1 / genetics. Matrix Metalloproteinase 3 / genetics. Thyroid Neoplasms / enzymology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Alleles. Female. Gene Frequency. Genetic Predisposition to Disease. Genotype. Humans. Male. Middle Aged. Neoplasm Staging. Polymerase Chain Reaction. Retrospective Studies. Risk Factors. Young Adult

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  • (PMID = 19432148.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 3.4.24.17 / Matrix Metalloproteinase 3; EC 3.4.24.7 / Matrix Metalloproteinase 1
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45. Kornprat P, Rehak P, Lemmerer M, Gogg-Kamerer M, Langner C: Analysis of trefoil factor family protein 1 (TFF1, pS2) expression in chronic cholecystitis and gallbladder carcinoma. Virchows Arch; 2005 May;446(5):505-10
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  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / pathology. Adenocarcinoma, Clear Cell / chemistry. Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Mucinous / chemistry. Adenocarcinoma, Mucinous / pathology. Adult. Aged. Aged, 80 and over. Analysis of Variance. Carcinoma, Adenosquamous / chemistry. Carcinoma, Adenosquamous / pathology. Carcinoma, Papillary / chemistry. Carcinoma, Papillary / pathology. Carcinoma, Signet Ring Cell / chemistry. Carcinoma, Signet Ring Cell / pathology. Chronic Disease. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucous Membrane / chemistry. Neoplasm Metastasis. Neoplasm Staging. Prognosis. Survival Rate. Trefoil Factor-1. Tumor Suppressor Proteins

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  • (PMID = 15821928.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Proteins; 0 / TFF1 protein, human; 0 / Trefoil Factor-1; 0 / Tumor Suppressor Proteins
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46. Nakanuma Y, Kitagawa S, Itazu K, Sato Y, Zen Y: [Histopathology of bile duct carcinoma and clinical symptoms]. Nihon Rinsho; 2006 Jan;64 Suppl 1:379-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / physiopathology. Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / physiopathology. Bile Duct Neoplasms / pathology. Bile Duct Neoplasms / physiopathology

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  • (PMID = 16457287.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 8
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47. Park JS, Son KR, Na DG, Kim E, Kim S: Performance of preoperative sonographic staging of papillary thyroid carcinoma based on the sixth edition of the AJCC/UICC TNM classification system. AJR Am J Roentgenol; 2009 Jan;192(1):66-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Performance of preoperative sonographic staging of papillary thyroid carcinoma based on the sixth edition of the AJCC/UICC TNM classification system.
  • OBJECTIVE: The purpose of this prospective study was to evaluate the overall performance of sonography for staging papillary thyroid carcinoma.
  • SUBJECTS AND METHODS: Ninety-four consecutive patients with papillary thyroid carcinoma underwent preoperative sonography.
  • CONCLUSION: Sonography is a feasible tool to use for the preoperative staging of papillary thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / epidemiology. Adenocarcinoma, Papillary / ultrasonography. Risk Assessment / methods. Thyroid Neoplasms / epidemiology. Thyroid Neoplasms / ultrasonography. Ultrasonography / statistics & numerical data

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  • [ErratumIn] AJR Am J Roentgenol. 2009 Mar;192(3):560
  • (PMID = 19098181.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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48. Capezzone M, Morabito E, Bellitti P, Giannasio P, de Santis D, Bruno R: Ectopic intrathyroidal nonfunctioning parathyroid cyst. Endocr Pract; 2007 Jan-Feb;13(1):56-8
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  • Measurement of parathyroid hormone in the FNAB fluid showed a high concentration, suggestive of the diagnosis of PC.
  • Histologic examination confirmed the diagnosis of intrathyroidal PC, and a papillary microcarcinoma (6 mm in diameter) was found in the right lobe of the thyroid.
  • CONCLUSION: Although an ectopic intrathyroidal PC is rare, the frequency of occult papillary microcarcinoma of the thyroid is high.
  • To our knowledge, this is the first report of an association of an intrathyroidal PC with papillary microcarcinoma of the thyroid.
  • [MeSH-major] Adenocarcinoma, Papillary / complications. Adenocarcinoma, Papillary / ultrasonography. Cysts / pathology. Parathyroid Diseases / complications. Thyroid Gland / pathology. Thyroid Neoplasms / complications. Thyroid Neoplasms / ultrasonography. Thyroid Nodule / complications. Thyroid Nodule / ultrasonography

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  • (PMID = 17360302.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Miura T, Igarashi Y, Okano N, Miki K, Okubo Y: Endoscopic diagnosis of intraductal papillary-mucinous neoplasm of the pancreas by means of peroral pancreatoscopy using a small-diameter videoscope and narrow-band imaging. Dig Endosc; 2010 Apr;22(2):119-23
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  • [Title] Endoscopic diagnosis of intraductal papillary-mucinous neoplasm of the pancreas by means of peroral pancreatoscopy using a small-diameter videoscope and narrow-band imaging.
  • BACKGROUND: Intraductal papillary-mucinous neoplasm (IPMN) is an intraductal tumor in which the mucin-producing epithelium shows proliferated papillary and a wide variety of pathological changes ranging from hyperplasia to adenocarcinoma.
  • Therefore, it is important to determine whether an IPMN is benign or malignant.
  • We carried out the differential diagnosis of benign lesion to malignant lesion.
  • METHODS: Between April 2003 and May 2009, PPS using a small-diameter videoscope by means of NBI was carried out on 21 hospitalized patients with IPMN (10 cases of adenocarcinoma, 11 cases of adenoma or hyperplasia; 14 males and seven females, with a mean age of 69.4 years).
  • RESULTS: Fifteen focal lesions of the 16 cases in the head of the pancreas (93.7%) and four focal lesions of the five cases in the pancreatic body (80%) were observable, whereas two lesions (adenocarcinoma in the pancreatic body, and adenoma in the uncus of pancreas) were not observable.
  • Endoscopically, seven cases were classified as villous type and two cases as vegetative type, and nine cases were diagnosed as adenocarcinoma.
  • CONCLUSIONS: When combined with a videoscope and NBI, pancreatoscopy provided a clear image and was useful for evaluating whether the IPMN was benign or malignant.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Endoscopes. Endoscopy, Digestive System / instrumentation. Pancreatic Ducts. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Equipment Design. Female. Humans. Hyperplasia / diagnosis. Male

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  • (PMID = 20447205.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] Australia
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50. Dagnew E, Langford LA, Lang FF, DeMonte F: Papillary tumors of the pineal region: case report. Neurosurgery; 2007 May;60(5):E953-5; discussion E953-5
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  • [Title] Papillary tumors of the pineal region: case report.
  • We report three patients initially considered to have metastatic papillary adenocarcinoma to the pineal region.
  • On review, these papillary, keratin-positive neoplasms meet the criteria for papillary tumor of the pineal region (PTPR).
  • The first two patients were initially diagnosed as having papillary metastatic carcinoma of unknown origin.
  • [MeSH-major] Brain Neoplasms / diagnosis. Pineal Gland / pathology. Pinealoma / diagnosis
  • [MeSH-minor] Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / surgery. Adult. Diagnosis, Differential. Female. Humans. Middle Aged


51. Sakuma Y, Okamoto N, Saito H, Yamada K, Yokose T, Kiyoshima M, Asato Y, Amemiya R, Saitoh H, Matsukuma S, Yoshihara M, Nakamura Y, Oshita F, Ito H, Nakayama H, Kameda Y, Tsuchiya E, Miyagi Y: A logistic regression predictive model and the outcome of patients with resected lung adenocarcinoma of 2 cm or less in size. Lung Cancer; 2009 Jul;65(1):85-90
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  • [Title] A logistic regression predictive model and the outcome of patients with resected lung adenocarcinoma of 2 cm or less in size.
  • Diagnostic criteria to identify small lung adenocarcinomas that relapse after resection have yet to be established.
  • We collected data for patients with lung adenocarcinoma of 2 cm or less in size: the original cohort comprised 28 men and 25 women and the validation cohort comprised 11 men.
  • By entering five clinicopathological factors (vascular invasion, lymphatic permeation, histological subtype, papillary carcinoma component, and smoking status) into the logistic model, we calculated a predictive function for relapse after surgery.
  • Consequently, using a logistic predictive model consisting of the five clinicopathological factors might enable us to predict the recurrence of resected small-sized lung adenocarcinomas in male patients.
  • [MeSH-major] Adenocarcinoma / surgery. Lung Neoplasms / surgery. Models, Statistical

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  • (PMID = 19027984.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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52. Batchelor EC, Watkins JM, Creasman WT, Kohler MF, Sinha D, Jenrette JM: The role of radiotherapy in the management of resected uterine papillary serous and clear cell carcinoma. Eur J Obstet Gynecol Reprod Biol; 2008 Dec;141(2):163-8
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  • [Title] The role of radiotherapy in the management of resected uterine papillary serous and clear cell carcinoma.
  • OBJECTIVE: Primary uterine papillary serous (PS) and clear cell (CC) carcinoma are aggressive histologies characterized by elevated risk of loco-regional recurrence and disease-specific mortality following hysterectomy.
  • The present study is a single institution, retrospective cohort comparison to determine whether post-hysterectomy radiotherapy improves loco-regional control and/or disease-specific survival outcomes in a population of women with PS and/or CC.
  • STUDY DESIGN: Between June 1992 and November 2006, 50 women underwent hysterectomy alone (H) or hysterectomy with adjuvant radiotherapy (H+RT) for primary uterine PS and/or CC.
  • RT involved either high dose-rate (HDR) brachytherapy, external beam RT, or both.
  • RESULTS: At a median survivor follow-up of 27 months (range 2.7-137.3) for the H+RT group and 61 months (range 11.9-114.6) for the H group (range 3-137), patients in the H+RT group demonstrated a trend toward superior disease-free survival (not yet attained at 26 months versus 25 months; p=0.0625).
  • For patients with > or =24 months of follow-up, disease recurrence was significantly higher in H patients over H+RT patients (45% versus 12.5%; p<0.05).
  • Additionally, the H+RT group demonstrated significant improvement in loco-regional control (0% versus 37.5%; p<0.001), most pronounced within FIGO stages I-II H+RT patients (0% versus 70%; p<0.001).
  • Overall survival was not significantly different between the two cohorts (H=32 months, H+RT=not yet attained at 26 months; p=non-significant).
  • CONCLUSIONS: Hysterectomy with adjuvant radiotherapy significantly improves disease-free survival within 2 years post-hysterectomy and significantly reduces loco-regional failures over hysterectomy alone.
  • [MeSH-major] Adenocarcinoma, Clear Cell / radiotherapy. Cystadenocarcinoma, Papillary / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Hysterectomy. Middle Aged. Radiotherapy, Adjuvant. Retrospective Studies. Uterine Neoplasms / radiotherapy. Uterine Neoplasms / surgery

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  • (PMID = 18774213.001).
  • [ISSN] 1872-7654
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA069222
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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53. Kamio Y, Maeda K, Moriya T, Takasu N, Takeshita A, Hirai I, Kimura W, Yamakawa M: Clinicopathological significance of cell cycle regulatory factors and differentiation-related factors in pancreatic neoplasms. Pancreas; 2010 Apr;39(3):345-52
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  • METHODS: The expression levels of cyclins A and B1, E1A-like inhibitor of differentiation 1 (EID-1), p300, 3'-5'-cyclic sdenosine monophosphate response element binding protein (CREB) binding protein (CBP), and acetylated histone H3 (AcH3) in ordinary ductal carcinoma (ODC) and intraductal papillary mucinous neoplasms (IPMNs) of the pancreas were investigated.
  • CONCLUSIONS: These results indicated that the expressions of cyclins A and B1, EID-1, and AcH3 may be correlated with a malignant potential in IPMNs.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Carcinoma, Pancreatic Ductal / pathology. Cell Cycle Proteins / metabolism. Cyclins / metabolism. Nuclear Proteins / metabolism. Pancreatic Neoplasms / pathology. Repressor Proteins / metabolism

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  • (PMID = 20335778.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Cyclin A; 0 / Cyclin B1; 0 / Cyclins; 0 / EID1 protein, human; 0 / Histones; 0 / Nuclear Proteins; 0 / Repressor Proteins; EC 2.3.1.48 / CREB-Binding Protein
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54. McCaffrey JC: Aerodigestive tract invasion by well-differentiated thyroid carcinoma: diagnosis, management, prognosis, and biology. Laryngoscope; 2006 Jan;116(1):1-11
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  • [Title] Aerodigestive tract invasion by well-differentiated thyroid carcinoma: diagnosis, management, prognosis, and biology.
  • METHODS: Basic science: immunohistochemical staining was used with antibodies against E-cadherin and beta-catenin in three groups of tissue: group 1, normal control thyroid tissue (n = 10); group 2, conventional papillary thyroid carcinoma (n = 20); group 3, IWDTC (n = 12).
  • Clinical: patients were divided into three surgical groups within the laryngotracheal subset: group 1, complete resection of gross disease (n = 34); group 2, shave excision (n = 75); group 3, incomplete excision (n = 15).
  • Removal of all gross disease is a major factor for survival.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Cadherins / blood. Esophageal Neoplasms / secondary. Laryngeal Neoplasms / secondary. Neoplasm Invasiveness / pathology. Thyroid Neoplasms / pathology. Tracheal Neoplasms / secondary

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  • (PMID = 16481800.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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55. Landoni L, Falconi M, Salvia R, Capelli P, Bettini R, Pederzoli P: A case of intraductal papillary mucinous tumour following recurrent attacks of pancreatitis lasting 26 years. Dig Liver Dis; 2007 Jun;39(6):585-8
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  • [Title] A case of intraductal papillary mucinous tumour following recurrent attacks of pancreatitis lasting 26 years.
  • At that time, medical history, absence of alcohol abuse, and radiological imaging suggested a diagnosis of idiopathic chronic pancreatitis.
  • Histological examination revealed an intraductal papillary mucinous non-invasive carcinoma.
  • This report represents a slippery case of misdiagnosis and demonstrates that follow-up is always mandatory following a diagnosis of idiopathic chronic pancreatitis.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Carcinoma, Pancreatic Ductal / etiology. Pancreatic Neoplasms / etiology. Pancreatitis / complications

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  • (PMID = 16843740.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Mucins
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56. Beschorner R, Schittenhelm J, Schimmel H, Iglesias-Rozas JR, Herberts T, Schlaszus H, Meyermann R, Wehrmann M: Choroid plexus tumors differ from metastatic carcinomas by expression of the excitatory amino acid transporter-1. Hum Pathol; 2006 Jul;37(7):854-60
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  • In addition, 77 metastatic carcinomas, including 64 adenocarcinomas with mostly papillary formations, derived from different organs were examined.
  • Establishing a cutoff value of 1% immunoreactive tumor cells served in adult cases to distinguish CPT from metastatic adenocarcinomas with 100% specificity and 70% sensitivity and was associated with positive and negative predictive values of 100% and 91%, respectively.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adolescent. Adult. Age Factors. Aged. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Infant. Infant, Newborn. Male. Middle Aged. Sex Factors

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  • (PMID = 16784985.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Excitatory Amino Acid Transporter 1
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57. Ozaki T, Kamura T, Ajioka Y, Shirai Y, Kurosaki I, Yamamoto S, Sasai K: Dynamic computed tomography findings of malignant intraductal papillary mucinous tumor compared with invasive ductal adenocarcinoma. Radiat Med; 2007 Nov;25(9):446-52
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  • [Title] Dynamic computed tomography findings of malignant intraductal papillary mucinous tumor compared with invasive ductal adenocarcinoma.
  • PURPOSE: We evaluated the effectiveness of dynamic computed tomography (CT) imaging in differentiating malignant intraductal papillary mucinous tumor (IPMT) with a large mural nodule from invasive ductal adenocarcinoma (IDAC).
  • RESULTS: Histologically, most of the mural nodule was papillary adenocarcinoma.
  • CONCLUSION: Dynamic CT is useful for differentiating malignant IPMT with a large mural nodule from IDAC.
  • [MeSH-minor] Aged. Contrast Media. Diagnosis, Differential. Female. Humans. Male. Neoplasm Invasiveness. Radiographic Image Interpretation, Computer-Assisted. Retrospective Studies

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  • (PMID = 18026902.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
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58. Brzakowski M, Fauvet R, Gondry J, Daraï E: [Endometrial cancer: survey of surgical practice in france in 2008]. J Gynecol Obstet Biol Reprod (Paris); 2010 Sep;39(5):409-17
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  • We aimed to assess the management of this disease among French surgeons as regards to the French guidelines.
  • They focused on the surgeon (age, gender, center of work, number of treated cancers individually and in the center) and on the disease (initial work-up, surgical management).
  • Three case reports related to endometrial cancer were proposed to assess the conformity of the French guidelines (two case reports about endometrioid carcinomas stages IB and II and one about serous papillary adenocarcinoma).

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20542646.001).
  • [ISSN] 1773-0430
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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59. Dietrich CF, Ignee A, Braden B, Barreiros AP, Ott M, Hocke M: Improved differentiation of pancreatic tumors using contrast-enhanced endoscopic ultrasound. Clin Gastroenterol Hepatol; 2008 May;6(5):590-597.e1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND & AIMS: Endoscopic ultrasound is a widely accepted imaging method for staging of ductal adenocarcinoma and the localization of neuroendocrine tumors of the pancreas.
  • METHODS: From 300 patients with pancreatic lesions investigated using contrast-enhanced endoscopic ultrasound we could finally include 93 patients with an undetermined, solitary, predominantly solid, lesion 40 mm or less, and a definite histologically proven diagnosis.
  • Fifty-seven of 62 patients with ductal adenocarcinoma of the pancreas showed a hypovascularity of the tumor using CE-EDUS.
  • [MeSH-major] Adenocarcinoma, Papillary / ultrasonography. Carcinoma, Pancreatic Ductal / ultrasonography. Contrast Media. Endosonography / methods. Image Enhancement. Pancreatic Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Pancreatitis / pathology. Pancreatitis / ultrasonography. Reproducibility of Results. Sensitivity and Specificity. Ultrasonography, Doppler, Color

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  • [CommentIn] Nat Clin Pract Gastroenterol Hepatol. 2008 Dec;5(12):662-3 [18852727.001]
  • (PMID = 18455699.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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60. Ito H, Endo T, Oka T, Matumoto T, Abe T, Toyota M, Imai K, Satoh M, Maguchi H, Shinohara T: Mucin expression profile is related to biological and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas. Pancreas; 2005 May;30(4):e96-102
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  • [Title] Mucin expression profile is related to biological and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas.
  • OBJECTIVES: Biologic and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas (IPMTs) were studied in reference to immunohistochemical mucin (MUC1, MUC2, and MUC5AC) expression.
  • Morphologic changes in imaging tests during the observation periods were most remarkable in the M1 group.
  • CONCLUSIONS: Our results suggest that MUC1 is related to malignant character but MUC5AC alone is related to benign character in IPMTs and that malignant potential of IPMTs expressing MUC2 depends on the degree of MUC2 expression.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Carcinoma, Papillary / metabolism. Mucins / metabolism. Pancreatic Neoplasms / metabolism

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  • (PMID = 15841035.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins; 0 / Tumor Suppressor Protein p53
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61. Bianco C, Strizzi L, Normanno N, Khan N, Salomon DS: Cripto-1: an oncofetal gene with many faces. Curr Top Dev Biol; 2005;67:85-133
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  • Furthermore, transgenic mouse studies have shown that overexpression of a human CR-1 transgene in the mammary gland under the transcriptional control of the mouse mammary tumor virus (MMTV) promoter results in mammary hyperplasias and papillary adenocarcinomas.

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  • (PMID = 15949532.001).
  • [ISSN] 1557-8933
  • [Journal-full-title] Current topics in developmental biology
  • [ISO-abbreviation] Curr. Top. Dev. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / Growth Substances; 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Glycoproteins; 0 / Neoplasm Proteins; 0 / TDGF1 protein, human; 62229-50-9 / Epidermal Growth Factor
  • [Number-of-references] 213
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62. Ito Y, Miyauchi A: Lateral lymph node dissection guided by preoperative and intraoperative findings in differentiated thyroid carcinoma. World J Surg; 2008 May;32(5):729-39
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  • METHODS: In this review we evaluate the indication of lateral lymph node dissection in papillary and follicular carcinomas based on the findings of previous reports, including those from our institute.
  • RESULTS: Lymph node metastasis and recurrence at the lymph node are common events in papillary carcinoma.
  • For N0 or N1a papillary carcinomas, male gender, being 55 or more years of age, a tumor larger than 3 cm, and massive extrathyroid extension are independent risk factors of lymph node recurrence, and patients with tumors having two or more of these clinicopathologic features showed high lymph node recurrence rates even if they underwent prophylactic lateral node dissection.
  • Prophylactic lateral node dissection is also recommended in N0 or N1a papillary carcinoma, if the lesion shows two or more of the aggressive characteristics indicated above.
  • [MeSH-major] Adenocarcinoma, Follicular / surgery. Carcinoma, Papillary / surgery. Lymph Node Excision. Thyroid Neoplasms / surgery

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  • (PMID = 18064515.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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63. Aparajita R, Gomez D, Verbeke CS, Menon KV: Papillary adenoma of the distal common bile duct associated with a synchronous carcinoma of the peri-ampullary duodenum. JOP; 2008;9(2):212-5
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  • [Title] Papillary adenoma of the distal common bile duct associated with a synchronous carcinoma of the peri-ampullary duodenum.
  • The diagnosis of these rare tumours is established on histopathological analysis following resection.
  • Coincidence of a biliary adenoma of the distal common bile duct and a synchronous adenocarcinoma of the peri-ampullary duodenum has never been reported in the literature.
  • CASE REPORT: We report a case of a papillary adenoma in the common bile duct in a 75-year-old female, who had synchronous invasive adenocarcinoma of the peri-ampullary duodenum.
  • CONCLUSION: Isolated papillary adenoma of the bile duct is extremely rare, and in this unusual case it coincided with a peri-ampullary duodenal adenocarcinoma.
  • However, this is a rare instance of an incidental finding within the distal bile duct following pancreaticoduodenectomy for curative treatment of a peri-ampullary adenocarcinoma.

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  • (PMID = 18326932.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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64. Oertel YC, Miyahara-Felipe L: Cytologic features of insular carcinoma of the thyroid: a case report. Diagn Cytopathol; 2006 Aug;34(8):572-5
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  • As its use becomes more widespread, the demand for more precise diagnosis has increased.
  • They consist of retrospective reviews of the aspirates (after the histologic diagnosis had been made from the thyroidectomy specimens).
  • A cytologic diagnosis of insular carcinoma can be suggested if multiple samples of a thyroidal mass are markedly cellular, with a cytologic pattern reminiscent of a follicular variant of papillary carcinoma.
  • [MeSH-major] Carcinoma / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Aged. Biopsy, Fine-Needle. Cytodiagnosis. Diagnosis, Differential. Humans. Male. Middle Aged

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16850485.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Jovanovic L, Delahunt B, McIver B, Eberhardt NL, Bhattacharya A, Lea R, Grebe SK: Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma. Pathology; 2010;42(6):524-33
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  • [Title] Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma.
  • AIMS: This study was undertaken to investigate the genetic factors underlying the development of multifocality and phenotypic diversity in multifocal papillary thyroid carcinoma (mPTC).
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Adenocarcinoma, Papillary / pathology. Biomarkers, Tumor / genetics. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology

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  • (PMID = 20854070.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA80117
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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66. Posligua L, Malpica A, Liu J, Brown J, Deavers MT: Combined large cell neuroendocrine carcinoma and papillary serous carcinoma of the endometrium with pagetoid spread. Arch Pathol Lab Med; 2008 Nov;132(11):1821-4
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  • [Title] Combined large cell neuroendocrine carcinoma and papillary serous carcinoma of the endometrium with pagetoid spread.
  • Neuroendocrine carcinomas of the endometrium are rare tumors that can be pure, combined with endometrioid adenocarcinoma, or a component of malignant mixed müllerian tumor.
  • Recently, a case of combined small cell carcinoma and papillary serous carcinoma of the endometrium was described for the first time.
  • We report the first case, to our knowledge, of combined large cell neuroendocrine carcinoma and papillary serous carcinoma of the endometrium, with an unusual pagetoid spread of the neuroendocrine component into normal endometrial and endocervical glands.
  • [MeSH-major] Carcinoma, Neuroendocrine / pathology. Carcinoma, Papillary / pathology. Endometrial Neoplasms / pathology

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  • (PMID = 18976022.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA083639; United States / NCI NIH HHS / CA / R01 CA131183
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Nakanishi Y, Zen Y, Hirano S, Tanaka E, Takahashi O, Yonemori A, Doumen H, Kawakami H, Itoh T, Nakanuma Y, Kondo S: Intraductal oncocytic papillary neoplasm of the bile duct: the first case of peribiliary gland origin. J Hepatobiliary Pancreat Surg; 2009;16(6):869-73
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  • [Title] Intraductal oncocytic papillary neoplasm of the bile duct: the first case of peribiliary gland origin.
  • We report herein the first case of intraductal oncocytic papillary neoplasm of the bile duct arising from a peribiliary gland of the left hepatic duct.
  • After pathological diagnosis of adenocarcinoma by cholangioscopic biopsy, a surgical hepatobiliary resection was performed.
  • Pathological examination revealed papillary tumor in the left hepatic duct.
  • Histologically, the tumor was identified as papillary neoplasm comprising oncocytic cells and delicate fibrovascular cores.
  • This case suggests that intraductal papillary neoplasm can arise from both biliary epithelium and peribiliary glands.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma in Situ / pathology

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  • (PMID = 19322511.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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68. Cirić J, Beleslin-Nedeljković B: [Differentiated thyroid carcinoma in previously manifested autoimmune thyroid disease]. Srp Arh Celok Lek; 2005 Oct;133 Suppl 1:74-6
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  • [Title] [Differentiated thyroid carcinoma in previously manifested autoimmune thyroid disease].
  • The role of autoimmune phenomena in the origin and clinical course of coexisting papillary and follicular carcinomas is still controversial.
  • In addition, radioiodine therapy for Graves' disease was found to be associated with increased incidence of thyroid cancer in some studies.
  • The presence of coexistent Hashimoto's thyroiditis does not affect the diagnostic evaluation and management of papillary thyroid cancer.
  • The frequent presentation of differentiated thyroid carcinomas in Graves' disease and Hashimoto's thyroiditis opens the possibility that some mutual pathogenethic mechanisms might be involved in the development of these diseases.
  • [MeSH-minor] Adenocarcinoma, Follicular / complications. Carcinoma, Papillary / complications. Graves Disease / complications. Hashimoto Disease / complications. Humans. Thyroid Nodule / complications

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  • (PMID = 16405261.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Serbia and Montenegro
  • [Number-of-references] 25
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69. Banzo J, Ubieto MA, Villalta J, Razola P, Prats E, Andrés A: [Incidental detection of a papillary thyroid cancer by ¹⁸F-FDG PET-CT study in a patient with metastatic colorectal cancer]. Rev Esp Med Nucl; 2010 Nov-Dec;29(6):312-3
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  • [Title] [Incidental detection of a papillary thyroid cancer by ¹⁸F-FDG PET-CT study in a patient with metastatic colorectal cancer].
  • [Transliterated title] Detección accidental de un carcinoma papilar de tiroides mediante ¹⁸F-FDG PET/TAC en un paciente con carcinoma colorrectal metastático.
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Papillary / radionuclide imaging. Liver Neoplasms / secondary. Neoplasms, Multiple Primary / radionuclide imaging. Positron-Emission Tomography. Sigmoid Neoplasms / radionuclide imaging. Thyroid Neoplasms / radionuclide imaging. Tomography, X-Ray Computed


70. Veras E, Mao TL, Ayhan A, Ueda S, Lai H, Hayran M, Shih IeM, Kurman RJ: Cystic and adenofibromatous clear cell carcinomas of the ovary: distinctive tumors that differ in their pathogenesis and behavior: a clinicopathologic analysis of 122 cases. Am J Surg Pathol; 2009 Jun;33(6):844-53
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  • Ovarian clear cell carcinomas (CCC) typically present as large adnexal, stage I tumors and are generally considered highly malignant.
  • Various features were analyzed including: age, race, laterality, tumor size, architectural pattern (papillary, tubulo-cystic, solid, mixed patterns), grade, mitotic index, association with endometriosis including atypical endometriosis/intraepithelial carcinoma, stage and survival.
  • A predominantly papillary pattern was seen in 47% of cystic CCCs, whereas none of the adenofibromatous carcinomas displayed a predominantly papillary pattern.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenofibroma / pathology. Cysts / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 19342944.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Hsu PI, Huang MS, Chen HC, Hsu PN, Lai TC, Wang JL, Lo GH, Lai KH, Tseng CJ, Hsiao M: The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer. J Surg Oncol; 2008 Jun 1;97(7):609-14
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  • However, the ANXA7 expression in different histological subtypes of gastric adenocarcinomas and its correlation with invasive potentials has not been elucidated.
  • METHODS: Immunohistochemical staining of ANXA7 for 84 primary gastric adenocarcinomas was performed, and data was correlated with clinicopathological parameters of patients.
  • Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively.
  • [MeSH-major] Adenocarcinoma / genetics. Annexin A7 / biosynthesis. Cell Differentiation / genetics. Stomach Neoplasms / genetics

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  • (PMID = 18449914.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Annexin A7
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72. Gourgiotis S, Ridolfini MP, Germanos S: Intraductal papillary mucinous neoplasms of the pancreas. Eur J Surg Oncol; 2007 Aug;33(6):678-84
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  • [Title] Intraductal papillary mucinous neoplasms of the pancreas.
  • BACKGROUND/AIMS: Intraductal papillary mucinous neoplasms (IPMNs) are neoplasms of the pancreatic duct epithelium characterized by intraductal papillary growth and thick mucin secretion.
  • This review encompasses IPMNs, including symptoms, diagnosis, management, and prognosis.
  • Most branch type IPMNs are benign, while the other two types are frequently malignant.
  • CONCLUSIONS: Prognosis is excellent after complete resection of benign and non-invasive malignant IPMNs.
  • Regular monitoring for disease recurrence is important after surgery.
  • [MeSH-major] Pancreatic Ducts / pathology. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Dilatation, Pathologic / pathology. Humans. Prognosis

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  • (PMID = 17207960.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 76
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73. Nepka Ch, Potamianos S, Karadana M, Barbanis S, Kapsoritakis A, Koukoulis G: Ascitic fluid cytology in a rare case of pseudomyxoma peritonei originating from intraductal papillary mucinous neoplasm of the pancreas. Cytopathology; 2009 Aug;20(4):271-3
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  • [Title] Ascitic fluid cytology in a rare case of pseudomyxoma peritonei originating from intraductal papillary mucinous neoplasm of the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Ascitic Fluid / pathology. Pancreatic Neoplasms / diagnosis. Peritoneal Neoplasms / diagnosis. Pseudomyxoma Peritonei / diagnosis

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  • (PMID = 19207311.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
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74. Chetty R: Intraductal papillary mucinous neoplasm with more than one histologic type of epithelium. J Gastrointestin Liver Dis; 2009 Jun;18(2):251-2
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  • [Title] Intraductal papillary mucinous neoplasm with more than one histologic type of epithelium.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Epithelial Cells / pathology. Pancreatic Neoplasms / pathology

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  • [CommentOn] J Gastrointestin Liver Dis. 2008 Dec;17(4):457-60 [19104710.001]
  • (PMID = 19565062.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Romania
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75. Roh JL, Kim JM, Park CI: Lateral cervical lymph node metastases from papillary thyroid carcinoma: pattern of nodal metastases and optimal strategy for neck dissection. Ann Surg Oncol; 2008 Apr;15(4):1177-82
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  • [Title] Lateral cervical lymph node metastases from papillary thyroid carcinoma: pattern of nodal metastases and optimal strategy for neck dissection.
  • BACKGROUND: The pattern of lateral cervical metastases from papillary thyroid carcinoma (PTC) has been reported without a clear understanding of the distribution of central nodes at risk.
  • RESULTS: For the lateral compartment, 75.9% of cases showed metastatic disease at level IV, 72.2% at IIa and III, 16.7% at IIb, 13.0% at Vai, 3.7% at Ib and Vb, and 0% at Vas.
  • For the central compartment, 84.6% of cases showed metastatic disease at the ipsilateral paratracheal nodal site, 46.2% at the superior mediastinal, 30.8% at the pretracheal, and 8.9% at the contralateral paratracheal site.
  • Forty-six of 57 lateral neck dissection samples (80.7%) showed multilevel disease, and skip lateral metastasis was found in five patients (9.6%).
  • Level I and V involvements were always associated with multilevel disease.
  • CONCLUSIONS: Lateral cervical metastasis from PTC is commonly associated with multilevel disease and central nodal involvement.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Lymph Nodes / pathology. Neck Dissection. Thyroid Neoplasms / pathology

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  • (PMID = 18253801.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Jang JY, Kim SW, Lee SE, Yang SH, Lee KU, Lee YJ, Kim SC, Han DJ, Choi DW, Choi SH, Heo JS, Cho BH, Yu HC, Yoon DS, Lee WJ, Lee HE, Kang GH, Lee JM: Treatment guidelines for branch duct type intraductal papillary mucinous neoplasms of the pancreas: when can we operate or observe? Ann Surg Oncol; 2008 Jan;15(1):199-205
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  • [Title] Treatment guidelines for branch duct type intraductal papillary mucinous neoplasms of the pancreas: when can we operate or observe?
  • BACKGROUND: The objectives of this study were to investigate the clinicopathological features of branch intraductal papillary mucinous neoplasm (IPMN) and to determine safe criteria for its observation.
  • There were 112 benign cases: 47 adenoma, 63 borderline cases, and 26 malignant cases, with 9 of these being noninvasive and 17 invasive.
  • CONCLUSIONS: Many branch duct IPMNs are malignant.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Adenoma / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 17909912.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Practice Guideline; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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77. Xiao GQ: Fine-needle aspiration of cystic pancreatic mucinous tumor: oncotic cell as an aiding diagnostic feature in paucicellular specimens. Diagn Cytopathol; 2009 Feb;37(2):111-6
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  • Cystic pancreatic mucinous tumors include mucinous cystic neoplasm and intraductal papillary mucinous tumor, both of which have been known to have a low malignant potential and a high rate of association with invasive adenocarcinoma.
  • As such, preoperative diagnosis is of great significance in guiding patient management.
  • Although fine-needle aspiration cytological diagnosis of pancreatic tumor in cellular specimens has been well described, as with other cystic lesions, the yield of diagnostic cells from needle aspiration of cystic pancreatic mucinous tumors is typically low.
  • Cytological diagnosis from these paucicellular specimens remains challenging.
  • In this current study, oncotic cells, characterized by cytoplasmic swelling and karyolysis, were analyzed from 17 cases of cystic pancreatic mucinous tumor, of which the diagnosis was either confirmed by surgical resection or supported by cell block and/or increased CEA.
  • None of the five fine-needle aspirations intended for aspirations of hypoechoic nonlesional pancreas, which yielded either gastrointestinal tract material only or admixture of gastrointestinal and normal pancreatic components, was found to contain oncotic cells, evidencing the utility of oncotic cell as a surrogate morphologic marker in aiding the diagnosis of cystic pancreatic mucinous tumor as well as its differentiation from gastrointestinal contaminant, particularly in paucicellular specimens.
  • [MeSH-major] Neoplasms, Cystic, Mucinous, and Serous / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 19021219.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Adotey JM: Papillary adenocarcinoma of thyroid in a patient with right submandibular mass--a rare case of 'lateral aberrant thyroid'. Niger J Clin Pract; 2009 Sep;12(3):333-4
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  • [Title] Papillary adenocarcinoma of thyroid in a patient with right submandibular mass--a rare case of 'lateral aberrant thyroid'.
  • BACKGROUND: Ectopic thyroid is a rare entity in the study of thyroid disease.
  • AIM: To report a case of papillary adenocarcinoma of thyroid within a right submandibular mass in a 67-year-old man.
  • The FNAB showed papillary adenocarcinoma of the thyroid.
  • CONCLUSION: This patient illustrates the even rarer case of a 'lateral aberrant thyroid' presenting as a malignant submandibular mass.
  • [MeSH-major] Adenocarcinoma / diagnosis. Choristoma / diagnosis. Submandibular Gland Diseases / diagnosis. Thyroid Gland. Thyroid Neoplasms / diagnosis

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  • (PMID = 19803039.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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79. Rong ZX, Fang CH, Zhu DJ, Liu SJ: [Expression of Smo protein and the downstream transcription factor Gli1 protein in Sonic hedgehog signal transduction pathway in gastric carcinoma]. Nan Fang Yi Ke Da Xue Xue Bao; 2006 Dec;26(12):1728-31
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  • RESULTS: Only weak expression, if any, of Smo and Gli1 proteins was detected in normal gastric mucosa, but in papillary adenocarcinoma, tubular adenocarcinoma and poorly differentiated adenocarcinoma, their expressions were significant increased as the differentiation degree was lowered.
  • CONCLUSION: The abnormal activity of Sonic hedgehog signal transduction pathway may play an important role in the occurrence of papillary adenocarcinoma, tubular adenocarcinoma and poorly differentiated adenocarcinoma, and this abnormality is associated with Smo protein overexpression, which upregulates the expression of the downstream transcription factor Gli1 protein.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / physiopathology. Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 17259107.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / GLI1 protein, human; 0 / Hedgehog Proteins; 0 / Receptors, G-Protein-Coupled; 0 / SMO protein, human; 0 / Transcription Factors
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80. Salla C, Chatzipantelis P, Konstantinou P, Karoumpalis I, Sakellariou S, Pantazopoulou A, Manika Z: Endoscopic ultrasound-guided fine-needle aspiration cytology in the diagnosis of intraductal papillary mucinous neoplasms of the pancreas. A study of 8 cases. JOP; 2007;8(6):715-24
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  • [Title] Endoscopic ultrasound-guided fine-needle aspiration cytology in the diagnosis of intraductal papillary mucinous neoplasms of the pancreas. A study of 8 cases.
  • CONTEXT: Intraductal papillary mucinous neoplasm (IPMN) is an increasingly recognized neoplasm of the pancreas, accounting for 5% of pancreatic neoplasms, it is considered difficult to diagnose by fine-needle aspiration (FNA) cytology.
  • OBJECTIVE: The aim of this study was to investigate the role of EUS-guided FNA cytology in the diagnosis of IPMN of the pancreas.
  • EUS/clinical findings, macroscopic/microscopic features of cell blocks and smears, and immunocytochemical stains accompanied by histopathologic diagnosis were recorded and studied.
  • Single atypical and irregular clusters were found in 3 cases (which were cytologically described as highly suggestive malignant IPMNs, and were histologically confirmed).
  • The histological diagnosis confirmed the FNA cytology diagnosis: 3 malignant IPMNs, 2 benign IPMNs and 3 borderline IPMNs.
  • Mucin 1 (MUC-1) was positive in 2 cases of malignant IPMN (histologically classified as null type ad intestinal type), mucin 2 (MUC-2) was positive in 3 cases (2 malignant both of the intestinal type, and 1 benign of the intestinal type I) and c-erbB2 was positive in 3 cases (2 benign - null and intestinal type - and 1 malignant null type).
  • CONCLUSIONS: The characteristic pre-operative EUS findings and cytomorphologic features, in addition to the immunocytochemical profile, were accurate indications and coincided with the final/post-operative histological diagnosis of IPMN.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / pathology. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / pathology


81. Grützmann R, Niedergethmann M, Pilarsky C, Klöppel G, Saeger HD: Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment. Oncologist; 2010;15(12):1294-309
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  • [Title] Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment.
  • Pancreatic intraductal papillary mucinous neoplasms (IPMNs) rank among the most common cystic tumors of the pancreas.
  • For a long time they were misdiagnosed as mucinous cystadenocarcinoma, ductal adenocarcinoma in situ, or chronic pancreatitis.
  • When resected in a preinvasive state patient prognosis is excellent, and even when they are already invasive, patient prognosis is more favorable than with ductal adenocarcinomas.
  • Whereas main duct IPMNs have a high risk for malignant progression, demanding their resection, branch duct IPMNs have a much lower risk for harboring malignancy.
  • [MeSH-major] Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / therapy. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Pancreatic Ductal / therapy. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / therapy. Humans. Prognosis

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  • (PMID = 21147870.001).
  • [ISSN] 1549-490X
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3227924
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82. Borzomati D, Valeri S, Grasso F, Rabitti C, Vitolo D, Santini D, Vincenzi B, Garberini A, La Vaccara V, Coppola R: Pancreatic intraductal papillary mucinous neoplasms: a paradigmatic case. A case report and review of the literature. Chir Ital; 2008 Jul-Aug;60(4):567-72
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  • [Title] Pancreatic intraductal papillary mucinous neoplasms: a paradigmatic case. A case report and review of the literature.
  • Pancreatic intraductal papillary mucinous neoplasms constitute an increasingly frequent clinical entity.
  • As a consequence, their clinical management is also presents controversial aspects ranging from follow-up to the advisability or otherwise of an aggressive surgical approach, even in the case of small non-malignant lesions.
  • In 2002 we observed a patient affected by a large pancreatic mass with the endoscopic and radiological features of an intraductal papillary mucinous tumour.
  • Total pancreatectomy was performed and final histology revealed a non-invasive papillary mucinous carcinoma of the pancreas.
  • Twenty-six months after surgical resection the patient is alive and free of disease.
  • [MeSH-major] Adenocarcinoma, Mucinous. Neoplasms, Multiple Primary. Pancreatic Neoplasms. Papilloma, Intraductal
  • [MeSH-minor] Diagnostic Errors. Humans. Male. Middle Aged. Pancreatitis / diagnosis

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  • (PMID = 18837259.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 40
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83. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A: Diagnostic and prognostic value of angiogenesis-modulating genes in malignant thyroid neoplasms. Surgery; 2005 Dec;138(6):1102-9; discussion 1109-10
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  • [Title] Diagnostic and prognostic value of angiogenesis-modulating genes in malignant thyroid neoplasms.
  • We postulated that expression analysis of genes that modulate angiogenesis would identify differentially expressed genes that would help to distinguish benign from malignant thyroid neoplasms and serve as markers of aggressive differentiated thyroid cancer.
  • METHODS: A complementary DNA (cDNA) array with 96 genes that modulate angiogenesis was used to identify differentially expressed genes (2-fold higher or lower) in malignant versus benign thyroid neoplasms.
  • Real-time quantitative polymerase chain reaction was used to confirm cDNA array expression data in 123 patients (4 normal thyroid, 26 hyperplastic nodules, 27 follicular adenomas, 23 follicular cancers, 18 follicular variant of papillary cancers, 25 papillary cancers).
  • RESULTS: Twenty-two genes were upregulated in malignant thyroid neoplasms by cDNA array analysis, but only 13 genes had higher messenger RNA (mRNA) expression levels in malignant than in benign thyroid neoplasms by real-time quantitative polymerase chain reaction (P < or = .04).
  • Of the 13 differentially expressed genes, the combined use of angiopoietin 2 (ANGPT2) and tissue inhibitor of metalloproteinase 1 (TIMP1) mRNA expression levels was best for distinguishing malignant from benign thyroid neoplasms, with a sensitivity of 90%, specificity of 85%, positive predictive value of 75%, and negative predictive value of 94%.
  • CONCLUSIONS: Angiopoietin 2 and tissue inhibitor of metalloproteinase 1 are diagnostic markers of malignant thyroid nodules and could improve the diagnostic accuracy of FNA biopsy.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenoma / genetics. Angiogenic Proteins / genetics. Carcinoma, Papillary / genetics. Carcinoma, Papillary, Follicular / genetics. Thyroid Neoplasms / genetics. Thyroid Nodule / genetics


84. Hagiwara T, Kaku T, Kobayashi H, Hirakawa T, Nakano H: Clinico-cytological study of uterine papillary serous carcinoma. Cytopathology; 2005 Jun;16(3):125-31
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  • [Title] Clinico-cytological study of uterine papillary serous carcinoma.
  • OBJECTIVE: The aim of this study was to determine whether or not we could distinguish uterine papillary serous carcinoma (UPSC) from other types of endometrial cancer by cytology.
  • METHODS: We examined the cytological findings of the endometrium from five cases with UPSC and compared them with 10 cases with endometrioid adenocarcinoma, grade 1 (G1).
  • Three patients died of the disease and two are still alive with disease.
  • The tumour cells of UPSC tended to be shed in papillary clusters with a tumour diathesis.
  • CONCLUSION: As the endometrial cytology findings accurately suggested the histological diagnosis of UPSC, the diagnosis of UPSC was confirmed in this study by endometrial cytology.
  • The cytological diagnosis of UPSC should be based on the findings of tumour diathesis, psammoma bodies and papillary clusters composed of tumour cells with enlarged nuclei and numerous nucleoli.
  • [MeSH-major] Cystadenocarcinoma, Papillary / pathology. Endometrial Neoplasms / pathology

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  • (PMID = 15924607.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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85. Fang JG, Ma HZ, Zhang ZB, Huang ZG, Chen XH, Zhou WG, Chen XJ, Han DM: [Total thyroidectomy: indications and complications]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Nov;45(11):904-7
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  • There were 48 cases of papillary adenocarcinoma, 1 follicular adenocarcinoma, and 2 medullary carcinoma as well, 2 cases with hyperthyroidism, 3 cases with remote metastasis.
  • Pathological examination showed that the multiple focal disease rate was 42.2% (19/45), the cervical lymph nodes metastases rate was 51.0% (26/51).
  • One case with contralateral lymph node metastasis was reoperated and survived without disease.
  • Two cases with remote metastasis were alive with steadied disease.

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  • (PMID = 21215203.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] Thyroid cancer, medullary
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86. Sohn MH, Kim MW, Lim ST, Lee NR, Song EK, Yim CY: Radioiodine uptake by metastatic nonthyroidal adenocarcinoma of the lung in a patient with papillary thyroid carcinoma. Clin Nucl Med; 2005 Apr;30(4):269-70
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  • [Title] Radioiodine uptake by metastatic nonthyroidal adenocarcinoma of the lung in a patient with papillary thyroid carcinoma.
  • A 49-year-old woman with a history of a hysterectomy for carcinoma of the cervix and papillary thyroid carcinoma showed multiple pulmonary metastases on chest radiography.
  • These lesions were found to be metastatic cervical adenocarcinoma.
  • The radioiodine uptake by the metastatic cervical adenocarcinoma of the lungs occurred in the presence of normal thyroid imaging in a patient with a thyroid nodule and papillary thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / radionuclide imaging. Iodine Radioisotopes / pharmacokinetics. Lung Neoplasms / metabolism. Lung Neoplasms / radionuclide imaging. Uterine Cervical Neoplasms / metabolism. Uterine Cervical Neoplasms / radionuclide imaging
  • [MeSH-minor] Carcinoma, Papillary / metabolism. Carcinoma, Papillary / radionuclide imaging. Diagnosis, Differential. Female. Humans. Middle Aged. Radiopharmaceuticals / pharmacokinetics. Thyroid Neoplasms / metabolism. Thyroid Neoplasms / radionuclide imaging


87. Edge MD, Hoteit M, Patel AP, Wang X, Baumgarten DA, Cai Q: Clinical significance of main pancreatic duct dilation on computed tomography: single and double duct dilation. World J Gastroenterol; 2007 Mar 21;13(11):1701-5
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  • Clinical course and ultimate diagnosis were obtained in all the identified patients by abstraction of their computer database records.
  • Patients with single duct dilation, especially such patients without any evidence of chronic pancreatitis, also need careful follow-up since the possibility of pancreatic malignancy, including adenocarcinoma and intraductal papillary mucinous tumors, is still high.
  • [MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Dilatation, Pathologic. Female. Humans. Liver / physiopathology. Male. Middle Aged. Pancreatic Neoplasms / complications. Pancreatic Neoplasms / radiography. Pancreatitis, Chronic / complications. Pancreatitis, Chronic / radiography. Predictive Value of Tests. Retrospective Studies. Risk Factors

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  • (PMID = 17461473.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4146949
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88. Otsuki Y, Yamada M, Shimizu S, Suwa K, Yoshida M, Tanioka F, Ogawa H, Nasuno H, Serizawa A, Kobayashi H: Solid-papillary carcinoma of the breast: clinicopathological study of 20 cases. Pathol Int; 2007 Jul;57(7):421-9
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  • [Title] Solid-papillary carcinoma of the breast: clinicopathological study of 20 cases.
  • The purpose of the present paper was to evaluate the clinicopathological and biological features of 20 Japanese patients with solid-papillary carcinoma of the breast (SPC) or SPC associated with invasive breast cancer.
  • The mean disease-free interval was 4 years 11 months.
  • When all the cases were classified and analyzed according to both the 2002 tumor node metastasis (TNM) classification system and the Nottingham histological grade, SPC patients, even those with invasive cancers, seemed to have longer disease-free survival compared to patients with the other invasive breast cancers of matching grade and stage.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Breast Neoplasms / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / chemistry. Adenocarcinoma, Mucinous / classification. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoma, Neuroendocrine / chemistry. Carcinoma, Neuroendocrine / classification. Carcinoma, Neuroendocrine / pathology. Carcinoma, Neuroendocrine / surgery. Disease-Free Survival. Female. Humans. Middle Aged. Neoplasms, Multiple Primary

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  • (PMID = 17587241.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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89. Montanaro F, Pury P, Bordoni A, Lutz JM, Swiss Cancer Registries Network: Unexpected additional increase in the incidence of thyroid cancer among a recent birth cohort in Switzerland. Eur J Cancer Prev; 2006 Apr;15(2):178-86
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  • Regression analyses for both sexes combined detected an increase in time for papillary cases and a decrease for other types.
  • Age-period-cohort analyses revealed that the youngest cohorts of men and women born after 1940 had an increased risk of all types of thyroid cancer while the cohort of people born between 1920 and 1939 were at increased risk of the papillary subtype.
  • [MeSH-major] Adenocarcinoma / epidemiology. Carcinoma, Papillary / epidemiology. Carcinoma, Papillary, Follicular / epidemiology. Neoplasms, Radiation-Induced / epidemiology. Thyroid Neoplasms / epidemiology

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  • (PMID = 16523016.001).
  • [ISSN] 0959-8278
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radioactive Fallout
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90. Pankhurst T, Howie AJ, Adu D, Wallace DM, Lipkin GW: Incidental neoplasms in renal biopsies. Nephrol Dial Transplant; 2006 Jan;21(1):64-9
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  • Twenty-two neoplasms were papillary, two were clear cell renal carcinomas and one was in situ carcinoma in a collecting duct.
  • The two clear cell carcinomas, three papillary neoplasms with residual masses after biopsy and the two papillary neoplasms in renal allografts were resected by nephrectomy or partial nephrectomy.
  • [MeSH-minor] Adenocarcinoma, Papillary / epidemiology. Adenocarcinoma, Papillary / pathology. Adult. Age Distribution. Aged. Aged, 80 and over. Biopsy, Needle. Carcinoma, Renal Cell / epidemiology. Carcinoma, Renal Cell / pathology. Female. Great Britain / epidemiology. Humans. Immunohistochemistry. Incidence. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Risk Assessment. Sex Distribution. Ultrasonography, Doppler

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  • (PMID = 16204290.001).
  • [ISSN] 0931-0509
  • [Journal-full-title] Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • [ISO-abbreviation] Nephrol. Dial. Transplant.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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91. Patel A, Lambiase L, Decarli A, Fazel A: Management of the mucin filled bile duct. A complication of intraductal papillary mucinous tumor of the pancreas. JOP; 2005 May;6(3):255-9
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  • [Title] Management of the mucin filled bile duct. A complication of intraductal papillary mucinous tumor of the pancreas.
  • CONTEXT: Biliary obstruction secondary to intrabiliary mucin is a relatively rare presentation of malignant intraductal pancreatic mucinous tumor.
  • Furthermore, this case differs from that commonly seen in the setting of pancreatic adenocarcinoma, where endoscopic or percutaneous biliary drainage is usually successful at long-term palliation from jaundice.
  • The diagnosis of intraductal pancreatic mucinous tumor was established based on diagnostic findings on computed tomography scan and endoscopic retrograde cholangiopancreatography.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Adenocarcinoma, Papillary / complications. Bile Ducts / chemistry. Carcinoma, Pancreatic Ductal / complications. Cholestasis / diagnosis. Cholestasis / etiology. Mucins / analysis. Pancreatic Neoplasms / complications
  • [MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde. Choledochostomy. Humans. Jaundice, Obstructive / diagnosis. Jaundice, Obstructive / etiology. Jaundice, Obstructive / pathology. Jaundice, Obstructive / surgery. Male. Stents

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  • (PMID = 15883476.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Mucins
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92. Lee I, Lim JH, Choi D, Jang KT, Lee KT, Choi SH: Intraductal papillary mucinous tumors of the pancreas: branch duct tumor penetrating the stomach and duodenum. AJR Am J Roentgenol; 2006 Dec;187(6):W604-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal papillary mucinous tumors of the pancreas: branch duct tumor penetrating the stomach and duodenum.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Papillary / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17114512.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Vaseemuddin M, Kraus MA: Quiz page. Acquired kidney disease (ACKD) with associated bilateral renal cell carcinoma. Am J Kidney Dis; 2005 Oct;46(4):A48, e47-9
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  • [Title] Quiz page. Acquired kidney disease (ACKD) with associated bilateral renal cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / complications. Carcinoma, Papillary / complications. Carcinoma, Renal Cell / complications. Kidney Neoplasms / complications. Neoplasms, Multiple Primary / complications. Polycystic Kidney Diseases / diagnostic imaging. Tomography, X-Ray Computed


94. Yagci G, Dede M, Guran S, Yenen MC, Durukan AH, Safali M: A papillary thyroid carcinoma case associated with hereditary colon carcinoma due to familial adenomatous polyposis with no hereditary mutation finding. Int J Colorectal Dis; 2007 Jun;22(6):725-6
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  • [Title] A papillary thyroid carcinoma case associated with hereditary colon carcinoma due to familial adenomatous polyposis with no hereditary mutation finding.
  • [MeSH-major] Adenocarcinoma, Papillary / complications. Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / genetics. Colonic Neoplasms / complications. Thyroid Neoplasms / complications


95. Okada T, Masuda N, Fukai Y, Shimura T, Nishida Y, Hosouchi Y, Kashiwabara K, Nakajima T, Kuwano H: Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas. Anticancer Res; 2006 Jul-Aug;26(4B):3105-10
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  • [Title] Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas.
  • However, the expression of 14-3-3 sigma in intraductal papillary-mucinous tumor (IPMT) of the pancreas remains unclear.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Biomarkers, Tumor / biosynthesis. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Papillary / metabolism. Exonucleases / biosynthesis. Neoplasm Proteins / biosynthesis. Pancreatic Neoplasms / metabolism


96. Wente MN, Schmied BM, Schmidt J, Büchler MW: [Differentiated therapy for intraductal papillary mucinous neoplasms]. Chirurg; 2009 Jan;80(1):7-13
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  • [Title] [Differentiated therapy for intraductal papillary mucinous neoplasms].
  • Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are of increasing interest in the field of pancreatic surgery ever since their first description as an individual pancreatic tumor entity in 1982.
  • Invasive IPMN forms (carcinoma in situ and invasive carcinoma) and in particular noninvasive IPMNs (adenoma and borderline tumors) reveal significantly better survival rates than ductal adenocarcinoma of the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Carcinoma in Situ / diagnosis. Carcinoma in Situ / mortality. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Staging. Pancreas / pathology. Prognosis. Radiography, Dual-Energy Scanned Projection. Survival Rate. Tomography, Spiral Computed

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  • (PMID = 19082569.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 50
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97. Matsuyama W, Yamamoto M, Machida K, Mitsuyama H, Watanabe M, Higashimoto I, Osame M, Arimura K: [Two lung adenocarcinoma patients with multiple brain metastasis treated with Gefitinib and surviving more than 2 years]. Nihon Kokyuki Gakkai Zasshi; 2006 Sep;44(9):653-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Two lung adenocarcinoma patients with multiple brain metastasis treated with Gefitinib and surviving more than 2 years].
  • Case 1 is a 78-year-old woman in whom lung adenocarcinoma with multiple brain metastasis (cT2N3M1, stage IV) was diagnosed.
  • Case 2 is an 80-year-old woman in whom lung adenocarcinoma with multiple brain (cT2N3M1, stage IV) was diagnosed.
  • We report two lung adenocarcinoma patients with multiple brain metastasis who survived more than 2 years by treatment with Gefitinib alone.
  • [MeSH-major] Adenocarcinoma, Papillary / drug therapy. Antineoplastic Agents / therapeutic use. Brain Neoplasms / secondary. Lung Neoplasms / drug therapy. Quinazolines / therapeutic use

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  • (PMID = 17037411.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Quinazolines; S65743JHBS / gefitinib
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98. Martín MA, Ferrás A: [Colon cancer: a rare complication in a colonic esophageal segment after coloesophagoplasty]. Cir Esp; 2005 Jan;77(1):46-7
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  • Adenocarcinoma was diagnosed in the colonic interposition.
  • [MeSH-major] Adenocarcinoma, Papillary / etiology. Colon / surgery. Colonic Neoplasms / etiology. Esophagus / surgery

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  • (PMID = 16420883.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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99. Dubova EA, Podgornova MN, Shchyogolev AI: Nuclear ploidy as an indicator of malignancy of intraductal pancreatic papillary mucinous tumors. Bull Exp Biol Med; 2010 Aug;149(2):255-7
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  • [Title] Nuclear ploidy as an indicator of malignancy of intraductal pancreatic papillary mucinous tumors.
  • We carried out comparative morphometric and densitometric analysis of cell nuclei in pancreatic intraductal papillary mucinous tumors.
  • Proliferative activity values, aneuploidy coefficient, and histogram of nuclear DNA content are recommended as additional criteria for the diagnosis of tumor malignancy.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Cell Nucleus / pathology. DNA / metabolism. Pancreatic Neoplasms / pathology. Ploidies

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  • (PMID = 21113504.001).
  • [ISSN] 1573-8221
  • [Journal-full-title] Bulletin of experimental biology and medicine
  • [ISO-abbreviation] Bull. Exp. Biol. Med.
  • [Language] eng; rus
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9007-49-2 / DNA
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100. Raut CP, Cleary KR, Staerkel GA, Abbruzzese JL, Wolff RA, Lee JH, Vauthey JN, Lee JE, Pisters PW, Evans DB: Intraductal papillary mucinous neoplasms of the pancreas: effect of invasion and pancreatic margin status on recurrence and survival. Ann Surg Oncol; 2006 Apr;13(4):582-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal papillary mucinous neoplasms of the pancreas: effect of invasion and pancreatic margin status on recurrence and survival.
  • BACKGROUND: The natural history and prognosis for patients with intraductal papillary mucinous neoplasms (IPMN) with and without invasion remain poorly defined.
  • Noninvasive IPMN was found in 22 (63%) of 35 patients; pathology re-review changed the original diagnosis from invasive to noninvasive IPMN in 6 patients.
  • Noninvasive IPMN was found at the final pancreatic margin in eight patients; none developed recurrent disease at a median follow-up of 34 months.
  • Recurrent disease was identified in 7 (58%) of 13 patients with invasive IPMN and in none with noninvasive IPMN.
  • Noninvasive IPMN, even if present at the pancreatic margin, was not associated with recurrent disease.
  • [MeSH-major] Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / mortality. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / mortality. Carcinoma, Papillary / pathology. Neoplasm Recurrence, Local

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  • [CommentIn] Gastroenterology. 2006 Dec;131(6):2020-2; discussion 2022 [17123531.001]
  • (PMID = 16523362.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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