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1. Son SH, Lee JS, Kim YS, Ryu MR, Chung SM, Namkoong SE, Han GT, Lee HJ, Yoon SC: The role of radiation therapy for the extramammary paget's disease of the vulva ; experience of 3 cases. Cancer Res Treat; 2005 Dec;37(6):365-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of radiation therapy for the extramammary paget's disease of the vulva ; experience of 3 cases.
  • We have experienced three cases of extramammary Paget's disease (EMPD) of the vulva that received radiation therapy (RT).
  • Here, we analyze the efficacy of RT and include a literature survey.Three patients with EMPD of the vulva were treated with curative RT between 1993 and 1998.
  • One of the patients had associated underlying adenocarcinoma of the vulva.
  • Marginal failure occurred in one patient, and another patient with underlying adenocarcinoma treated by vulvectomy with bilateral inguinal lymph node dissection followed by external RT showed no relapse.

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  • (PMID = 19956374.001).
  • [ISSN] 2005-9256
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2785940
  • [Keywords] NOTNLM ; EMPD / Extramammary Paget's disease of vulva / RT / Radiotherapy
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2. Huang YD, Hung YC, Yeh LS, Chiang IP, Zeng GC, Chang WC: Synchronous ovarian endometrioid adenocarcinoma and endocervical mucinous adenocarcinoma. Taiwan J Obstet Gynecol; 2006 Sep;45(3):264-7
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  • [Title] Synchronous ovarian endometrioid adenocarcinoma and endocervical mucinous adenocarcinoma.
  • OBJECTIVE: We report a rare case of synchronous cancer consisting of ovarian endometrioid adenocarcinoma and endocervical mucinous adenocarcinoma.
  • Cytology of the pleural effusion showed no malignant cells.
  • Histology showed moderately to poorly differentiated endometrioid adenocarcinoma of the right ovary with extensive lymphovascular permeation, as well as paraaortic and bilateral pelvic lymph node metastases.
  • Endocervical adenocarcinoma, < 3 mm in depth, was also identified on the cervix.
  • The final surgical-pathologic stage of ovarian endometrioid adenocarcinoma was stage IIIc and of endocervical mucinous adenocarcinoma was stage IA1.
  • Adjuvant chemotherapy with carboplatin and paclitaxel was prescribed postoperatively, but the malignancy was not controlled due to lung, brain and vulva metastases.
  • Diagnosis should be based on histologic examination and requires appropriate treatment for both tumors.
  • [MeSH-major] Adenocarcinoma, Mucinous / epidemiology. Carcinoma, Endometrioid / epidemiology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / epidemiology. Uterine Cervical Neoplasms / epidemiology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / secondary. Carcinoembryonic Antigen / metabolism. Combined Modality Therapy. Female. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis. Necrosis. Vulvar Neoplasms / secondary

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  • (PMID = 17175478.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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3. Madeleine MM, Johnson LG, Smith AG, Hansen JA, Nisperos BB, Li S, Zhao LP, Daling JR, Schwartz SM, Galloway DA: Comprehensive analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci and squamous cell cervical cancer risk. Cancer Res; 2008 May 1;68(9):3532-9
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  • The main multilocus associations were replicated in studies of cervical adenocarcinoma and vulvar cancer.

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  • (PMID = 18451182.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL094260; United States / NCI NIH HHS / CA / CA112512-02; United States / NCI NIH HHS / CA / R01CA112512; United States / NCI NIH HHS / CA / R01 CA112512-02; United States / NCI NIH HHS / CA / P01CA042792; United States / NCI NIH HHS / CA / CA112512-01; United States / NCI NIH HHS / CA / CA112512-04; United States / NCI NIH HHS / CA / R01 CA112512-01; United States / NCI NIH HHS / CA / R01 CA112512-03; United States / NIEHS NIH HHS / ES / P30 ES007033-13; United States / NCI NIH HHS / CA / CA042792-19A1; United States / NIEHS NIH HHS / ES / P30 ES007033; United States / NCI NIH HHS / CA / R01 CA112512-04; United States / NCI NIH HHS / CA / P01 CA042792; United States / NCI NIH HHS / CA / CA112512-03; None / None / / P30 ES007033-13; United States / NIEHS NIH HHS / ES / P01ES07033; United States / NCI NIH HHS / CA / P01 CA042792-19A1; United States / NCI NIH HHS / CA / CA112512-05; United States / NCI NIH HHS / CA / R01 CA112512-05; United States / NCI NIH HHS / CA / R01 CA112512
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HLA-A Antigens; 0 / HLA-B Antigens; 0 / HLA-C Antigens; 0 / HLA-DQ Antigens; 0 / HLA-DQ beta-Chains; 0 / HLA-DQB1 antigen; 0 / HLA-DR Antigens; 0 / HLA-DRB1 Chains; 0 / HLA-DRB1*03:01 antigen; 0 / HLA-DRB1*04:01 antigen; 0 / Membrane Glycoproteins
  • [Other-IDs] NLM/ NIHMS85424; NLM/ PMC2662593
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4. Baron M, Hitzel A, Sartor A, d'Anjou J, Dessogne P: [Paget's disease of the vulva: interest of sentinel lymph node analysis]. Gynecol Obstet Fertil; 2006 Jul-Aug;34(7-8):619-21
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  • [Title] [Paget's disease of the vulva: interest of sentinel lymph node analysis].
  • Paget's disease of the vulva is difficult to diagnose, as far as the extent of this lesion is concerned, since it is often coupled with invasive adenocarcinoma of the vulva.
  • Thus, we present two cases of Paget's disease of the vulva, with use of sentinel lymph node analysis- a non-validated technique in this very context.
  • [MeSH-major] Paget Disease, Extramammary / diagnosis. Sentinel Lymph Node Biopsy. Vulvar Diseases / diagnosis
  • [MeSH-minor] Adenocarcinoma / complications. Aged. Diagnosis, Differential. Female. Humans. Vulvar Neoplasms / complications

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  • (PMID = 16854611.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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5. Tanaka H, Umekawa T, Nagao K, Ishihara A, Toyoda N: Adenocarcinoma of mammary-like glands in the vulva successfully treated by weekly paclitaxel. Int J Gynecol Cancer; 2005 May-Jun;15(3):568-71
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  • [Title] Adenocarcinoma of mammary-like glands in the vulva successfully treated by weekly paclitaxel.
  • This disease was diagnosed as an adenocarcinoma arising in mammary-like glands of the vulva.
  • In our case, the fine-needle aspiration cytology was a rapid and minimally invasive method of diagnosis, and the findings were extremely similar to those of the scirrhus type of primary breast carcinoma.
  • Rapid and accurate diagnosis made with this technique might contribute to a good prognosis in the early-staged cases.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Agents, Phytogenic / therapeutic use. Paclitaxel / therapeutic use. Vulvar Neoplasms / drug therapy

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  • (PMID = 15882189.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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6. Dimitroulas T, Settas L: Paget's disease of the vulva in a patient with scleroderma and underlying adenocarcinoma: case report. Eur J Gynaecol Oncol; 2009;30(4):458-9
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  • [Title] Paget's disease of the vulva in a patient with scleroderma and underlying adenocarcinoma: case report.
  • We report a case of a 71-year-old woman with SSc, who presented with an eczematous lesion of the vulva.
  • The diagnosis of Paget's disease of the vulva (PVD) was established.
  • The patient underwent radical vulvectomy, but 18 months later died due to adenocarcinoma of unknown primary origin.
  • [MeSH-major] Adenocarcinoma / pathology. Neoplasms, Multiple Primary. Neoplasms, Unknown Primary. Paget Disease, Extramammary / complications. Scleroderma, Systemic / complications. Vulvar Neoplasms / complications

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  • (PMID = 19761147.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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7. Petković S, Jeremić K, Vidakovic S, Jeremić J, Lazović G: Paget's disease of the vulva--a review of our experience. Eur J Gynaecol Oncol; 2006;27(6):611-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paget's disease of the vulva--a review of our experience.
  • OBJECTIVE: The aim of our study was to review our experience with Paget's disease of the vulvar relative to initial examination, treatment and oncological outcome.
  • METHODS: Ten women with extramammary Paget's diseases of the vulva were treated during the 10-year period.
  • RESULTS: Eight women (80%) were treated with wide local excision or partial vulvectomy, and two patients (20%) required radical resection for invasive adenocarcinoma.
  • CONCLUSION: Recurrence is very common and long-term monitoring is recommended with careful examination of any abnormal vulvar lesion.
  • [MeSH-major] Adenocarcinoma / surgery. Neoplasm Recurrence, Local / surgery. Paget Disease, Extramammary / surgery. Vulvar Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Lymph Node Excision. Middle Aged. Treatment Outcome. Vulvar Lichen Sclerosus

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  • (PMID = 17290594.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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8. Abbott JJ, Ahmed I: Adenocarcinoma of mammary-like glands of the vulva: Report of a case and review of the literature. Am J Dermatopathol; 2006 Apr;28(2):127-33
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  • [Title] Adenocarcinoma of mammary-like glands of the vulva: Report of a case and review of the literature.
  • Mammary-like glands are a poorly recognized structure of normal vulvar skin.
  • Excisional biopsy and Mohs micrographic surgery demonstrated an infiltrating adenocarcinoma of the mammary-like glands involving the dermis and subcutis.
  • On review of all 20 cases, the mean age at diagnosis was 59.6 years, the labia majora were involved in 13 cases (65%), and the mean lesional size was 2.5 cm.
  • The tumor's histologic patterns varied greatly, although the histomorphologic similarity among this neoplasm, sweat gland carcinomas, and invasive extramammary Paget disease suggested a morphologic spectrum among these tumors.
  • Criteria for establishing the diagnosis of adenocarcinoma of mammary-like glands include identifying transition zones between normal mammary-like glands and adenocarcinomatous areas.
  • This tumor is best categorized as a locally aggressive neoplasm with a low risk for widespread metastasis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Vulvar Neoplasms / diagnosis

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  • (PMID = 16625074.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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9. Giordano G, Gnetti L, Melpignano M: Endometrial carcinoma metastatic to the vulva: a case report and review of the literature. Pathol Res Pract; 2005;201(11):751-6
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  • [Title] Endometrial carcinoma metastatic to the vulva: a case report and review of the literature.
  • In this paper, we report a new case of metastatic endometrial carcinoma to the vulva and describe the clinical and pathological features.
  • Moreover, we discuss the criteria for the differential diagnosis of endometrial carcinoma metastatic to the vulva, the primary vulvar adenocarcinomas, and other metastatic adenocarcinomas.
  • The patient, previously diagnosed to have endometrial adenocarcinoma with squamous differentiation at III C stage (according to the FIGO system) and T2N1M0 stage (according to the TNM system), presented with a small plaque on the vulvar mucosa 8 months after endometrial primary carcinoma had been diagnosed.
  • The histological evaluation of excisional vulvar biopsy revealed a neoplasm with pathological features of endometrial carcinoma.
  • Thus, the final diagnosis was metastatic endometrial carcinoma to the vulva.
  • Fourteen months after the diagnosis of primary endometrial carcinoma, the patient died of disseminated metastatic lesions.
  • In conclusion, metastatic endometrial carcinoma to the vulva, although rare, might develop and could appear within a few months after the diagnosis of primary tumor.
  • Moreover, in the presence of metastatic endometrial carcinoma to the vulva, it is necessary to verify if other visceral metastases are present.
  • [MeSH-major] Adenocarcinoma / secondary. Endometrial Neoplasms / pathology. Vulvar Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Neoplasm Staging. Prognosis

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  • (PMID = 16325518.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 17
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10. Klapsinou E, Terzakis E, Arnogiannaki N, Daskalopoulou D: Paget's disease of the vulva detected in vulvar and vaginal brushing smears: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):898-902
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  • [Title] Paget's disease of the vulva detected in vulvar and vaginal brushing smears: a case report.
  • BACKGROUND; Vulvar Paget's disease comprises only 1-8% of malignant vulvar tumors.
  • CASE: A 75-year-old woman presented with erythematous plaques covering the entire vulvar, vaginal and perianal area and pruritus.
  • Additionally, biopsies were taken from the vulva, vagina and outer borders of the lesion and were stained with hematoxylin-eosin and also for periodic acid-Schiff stain, CK7, CEA, S-100 and CK20.
  • The histologic findings confirmed the cytologic diagnosis.
  • No indication of an underlying adenocarcinoma was found.
  • CONCLUSION: Although the histologic examination of a vulvar lesion is necessary in order to confirm the diagnosis of vulvar Paget's disease and rule out the possibility of an underlying invasive adenocarcinoma, the cytologic examination of vulvar smears is useful for alerting the clinician to the possibility of vulvar Paget's disease.
  • [MeSH-major] Paget Disease, Extramammary / pathology. Papanicolaou Test. Vaginal Smears. Vulva / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 21053565.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Niikura H, Yoshida H, Ito K, Takano T, Watanabe H, Aiba S, Yaegashi N: Paget's disease of the vulva: clinicopathologic study of type 1 cases treated at a single institution. Int J Gynecol Cancer; 2006 May-Jun;16(3):1212-5
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  • [Title] Paget's disease of the vulva: clinicopathologic study of type 1 cases treated at a single institution.
  • The aim of this study was to evaluate clinicopathologic characteristics of primary cutaneous Paget's disease of the vulva.
  • Between 1986 and 2005, 22 patients with primary cutaneous Paget's disease of the vulva (type 1) were treated at Tohoku University Hospital.
  • Medical records were reviewed for pathologic diagnosis, patient age, associated neoplasms, type(s) of eczema, symptom duration, treatment, surgical procedures, recurrence, and length of follow-up.
  • Type 1a (intraepithelial) Paget's disease accounted for 18 patients, with 3 type 1b (invasive) cases and 1 type 1c (intraepithelial disease with underlying adenocarcinoma) case.
  • The rate of secondary malignancy seems to be low in primary cutaneous Paget's disease of the vulva.
  • Inguinal lymphadenectomy is recommended in cases with question of invasion or known underlying adenocarcinoma.
  • [MeSH-major] Paget Disease, Extramammary / diagnosis. Vulva. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Aged. Aged, 80 and over. Carcinoma in Situ / diagnosis. Fatal Outcome. Female. Humans. Middle Aged. Neoplasm Invasiveness / diagnosis. Neoplasm Staging. Neoplasms, Multiple Primary / diagnosis

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  • (PMID = 16803508.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Sendagorta E, Herranz P, Feito M, Ramírez P, Floristán U, Feltes R, Benito DM, Casado M: Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod--proposal of a therapeutic schedule. J Eur Acad Dermatol Venereol; 2010 Apr;24(4):490-2
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  • [Title] Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod--proposal of a therapeutic schedule.
  • BACKGROUND/AIM: Extramammary Paget's disease (EMPD) is an intraepidermal adenocarcinoma of apocrine gland-bearing skin.
  • METHODS: Three patients diagnosed of EMPD of the vulva were treated with a daily application of 5% Imiquimod cream for three weeks, followed by an every other day application for an additional three weeks.
  • CONCLUSION: Based on our results, we consider that Imiquimod cream is a safe and effective therapeutic option for the treatment of vulvar EMPD.
  • [MeSH-major] Aminoquinolines / administration & dosage. Antineoplastic Agents / administration & dosage. Paget Disease, Extramammary / drug therapy. Skin Neoplasms / drug therapy. Vulvar Neoplasms / drug therapy

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  • (PMID = 19840203.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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13. Fracchioli S, Puopolo M, De La Longrais IA, Scozzafava M, Bogliatto F, Arisio R, Micheletti L, Katsaros D: Primary "breast-like" cancer of the vulva: a case report and critical review of the literature. Int J Gynecol Cancer; 2006 Jan-Feb;16 Suppl 1:423-8
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  • [Title] Primary "breast-like" cancer of the vulva: a case report and critical review of the literature.
  • Ectopic mammary gland tissue in the vulva is an uncommon clinical or pathologic finding.
  • However, the occurrence of adenocarcinoma is very rare, the first case being reported by Greene in 1935.
  • We here report the 16th case of primary "breast-like" cancer arising in the vulva, together with a critical review of the literature, in order to highlight the dilemmas of a clinical approach to this neoplasm.
  • Clear guidelines for diagnosis and therapy are still unavailable.
  • In our opinion, when diagnosis of breast-like vulvar cancer is finally confirmed, treatment and follow-up should be the same as that would be chosen in a case of orthotopic breast neoplasm.
  • [MeSH-major] Carcinoma, Ductal, Breast / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 16515638.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; U3P01618RT / Fluorouracil; CAF protocol
  • [Number-of-references] 33
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14. Shah SS, Adelson M, Mazur MT: Adenocarcinoma in situ arising in vulvar papillary hidradenoma: report of 2 cases. Int J Gynecol Pathol; 2008 Jul;27(3):453-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma in situ arising in vulvar papillary hidradenoma: report of 2 cases.
  • Adenocarcinoma in situ rarely occurs in vulvar papillary hidradenoma.
  • We encountered 2 cases of adenocarcinoma in situ arising in a papillary hidradenoma of the vulva.
  • Both patients were asymptomatic women, aged 83 and 92 years, who presented with nodules (1.0 and 2.0 cm) on the vulva.
  • On microscopic examination, the tumors showed focal features of benign hidradenoma at the periphery with transitions into areas of increasing cytologic atypia that fulfilled criteria for adenocarcinoma in situ similar to that seen in the breast.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Carcinoma in Situ / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 18580327.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Dubé V, Lickrish GM, MacNeill KN, Colgan TJ: Villoglandular adenocarcinoma in situ of intestinal type of the hymen: de novo origin from squamous mucosa? J Low Genit Tract Dis; 2006 Jul;10(3):156-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Villoglandular adenocarcinoma in situ of intestinal type of the hymen: de novo origin from squamous mucosa?
  • Villoglandular adenocarcinoma of intestinal type is a very uncommon neoplasm of unknown origin with only few cases described on the vulva and in the vagina.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma in Situ / diagnosis. Hymen / pathology. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Epithelium / pathology. Female. Humans. Middle Aged. Vaginal Discharge / etiology

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  • (PMID = 16829755.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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16. Neihaus SA, Winter JE, Goring RL, Kennedy FA, Kiupel M: Primary clitoral adenocarcinoma with secondary hypercalcemia of malignancy in a dog. J Am Anim Hosp Assoc; 2010 May-Jun;46(3):193-6
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  • [Title] Primary clitoral adenocarcinoma with secondary hypercalcemia of malignancy in a dog.
  • This report describes a primary clitoral adenocarcinoma in a dog with secondary hypercalcemia of malignancy.
  • A 10-year-old, spayed female basset hound was evaluated for a mass protruding from the vulva.
  • The mass was excised, and a histological diagnosis of clitoral adenocarcinoma was made.
  • Cellular features were similar to an apocrine gland anal sac adenocarcinoma, and immunohistochemistry exhibited features noted with apocrine gland anal sac adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / veterinary. Clitoris. Dog Diseases / diagnosis. Hypercalcemia / veterinary. Vulvar Neoplasms / veterinary

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  • (PMID = 20439943.001).
  • [ISSN] 1547-3317
  • [Journal-full-title] Journal of the American Animal Hospital Association
  • [ISO-abbreviation] J Am Anim Hosp Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Shaco-Levy R, Bean SM, Vollmer RT, Jewell E, Jones EL, Valdes CL, Bentley RC, Selim MA, Robboy SJ: Paget disease of the vulva: a study of 56 cases. Eur J Obstet Gynecol Reprod Biol; 2010 Mar;149(1):86-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paget disease of the vulva: a study of 56 cases.
  • OBJECTIVE: To resolve controversial issues regarding vulvar Paget disease through analysis of a substantial number of cases.
  • STUDY DESIGN: The medical records and pathology slides of 56 patients with a diagnosis of vulvar Paget disease were reviewed.
  • RESULTS: Most patients were Caucasian and their mean age at diagnosis was 69 years.
  • Substantial delay between appearance of symptoms and diagnosis was observed in many patients, and was significantly associated with larger lesions.
  • On the last day of follow-up 24 patients (43%) had no evidence of disease, 24 patients (43%) were dead of other causes, 5 patients (9%) were alive with disease, 2 patients (3%) were lost to follow-up, and 1 (2%) died due to vulvar Paget disease with invasive adenocarcinoma.
  • CONCLUSIONS: Vulvar Paget disease only rarely results in a patient's death, but long term follow-up is required, as recurrences are common and can be noted many years after the initial treatment.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Paget Disease, Extramammary / pathology. Vulva / pathology. Vulvar Neoplasms / pathology

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19969410.001).
  • [ISSN] 1872-7654
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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18. do Val IC, Almeida Filho GL, Corrêa A, Neto N: Chronic hidradenitis suppurativa and perianal mucinous adenocarcinoma. A case report. J Reprod Med; 2007 Feb;52(2):100-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chronic hidradenitis suppurativa and perianal mucinous adenocarcinoma. A case report.
  • This is the first case report of hidradenitis suppurativa in the vulvar region associated with perianal mucinous adenocarcinoma.
  • CASE: The patient was a 48-year-old woman who presented with extensive hidradenitis suppurativa in the vulvar and perianal regions.
  • A diagnosis of perianal mucinous adenocarcinoma was made.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Hidradenitis Suppurativa / complications. Skin Neoplasms / etiology
  • [MeSH-minor] Female. Humans. Middle Aged. Perineum. Vulva

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  • (PMID = 17393769.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Alsaad KO, Obaidat N, Dube V, Chapman W, Ghazarian D: Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. Pathol Res Pract; 2009;205(2):131-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation.
  • Primary vulvar adenocarcinomas are rare tumors, and their histogenesis is not fully understood.
  • They are classified into extramammary Paget's disease, sweat gland carcinomas, and "breast-like" adenocarcinomas of the vulva.
  • Rare cases of adenocarcinoma with apocrine features have been reported, and whether these neoplasms originate from the "native apocrine" sweat glands or from "anogenital mammary-like" glands are still debatable.
  • The presence of normal mammary-like glands in the vicinity of the tumor, the transitional malignant morphological features from normal mammary-like glands and the tumor, the breast-like histological features of the tumor, and the expression of estrogen and progesterone receptors generally suggest an origin from anogenital mammary-like glands.
  • In this report, we present a patient who was initially diagnosed with Paget's disease of the right vulva, which was treated by hemi-vulvectomy, and who later presented with primary vulvar apocrine adenocarcinoma with metastasis to the inguinal lymph nodes and intranodal mucinous/colloidal differentiation: a feature, to the best of our knowledge, not reported before.
  • We also reviewed the histogenesis of the vulvar adenocarcinomas, with emphasis on the morphological features that separate the tumors arising from the anogenital mammary-like glands in the vulva from those arising from the native vulvar sweat glands.
  • [MeSH-major] Adenocarcinoma / pathology. Apocrine Glands / pathology. Lymphatic Metastasis / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Aged, 80 and over. Arthritis, Rheumatoid / complications. Cell Differentiation. Female. Gynecologic Surgical Procedures. Humans. Hypertension / complications. Osteoporosis / complications. Paget Disease, Extramammary / complications

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  • (PMID = 18842349.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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20. Ferrandina G, Testa AC, Zannoni GF, Poerio A, Scambia G: Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report. Gynecol Oncol; 2005 Aug;98(2):322-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report.
  • BACKGROUND: Metastatic bone involvement in vulvar squamous carcinoma is very rare.
  • Here, we present a case of primary adenocarcinoma of the Bartholin's gland giving rise to isolated skull metastasis.
  • CASE: A 74-year-old woman was referred with a diagnosis of primary vulvar adenocarcinoma of the right labium minus.
  • A right hemivulvectomy was performed with ipsilateral inguinofemoral lymphadenectomy, revealing a primary adenocarcinoma of the Bartholin's gland and metastatic involvement in 6 out of 13 lymphnodes.
  • The diagnosis was metastatic poorly differentiated adenocarcinoma.
  • CONCLUSION: In adenocarcinoma of the Bartholin's gland at an advanced stage of disease, a bone scan or survey in the preoperative as well as follow up staging procedures could be useful.
  • [MeSH-major] Adenocarcinoma / secondary. Bartholin's Glands / pathology. Skull Neoplasms / secondary. Vulvar Neoplasms / pathology

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  • (PMID = 15936060.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Hou JL, Wu LY, Zhang HT, Lv NN, Huang Y, Yu GZ: Clinicopathologic characteristics of 12 patients with vulvar sweat gland carcinoma. Int J Gynecol Cancer; 2010 Jul;20(5):874-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic characteristics of 12 patients with vulvar sweat gland carcinoma.
  • OBJECTIVES: The aim of this article was to evaluate the clinical and pathologic characteristics, therapy, and prognostic factors of vulvar sweat gland carcinoma.
  • MATERIALS: Clinical and pathologic data for 12 patients with vulvar sweat gland carcinoma treated at our institution from January 1958 to April 2009 were retrospectively analyzed.
  • Of the 12 cases, 7 cases were vulvar sweat gland carcinoma, 3 cases were vulvar Paget disease with underlying sweat gland adenocarcinoma, 1 case was vulvar apocrine adenocarcinoma, and 1 case was adenoid cystic carcinoma of the vulvar sweat gland.
  • Two patients were treated with simple vulvar tumor excision at other medical institutions without adjuvant therapy.
  • Among the other 10 patients, 6 underwent radical vulvectomy; 3, wide local excision of the vulva; and 1, a simple vulvectomy.
  • For 1 patient with bulky inguinal lymph nodes, only a biopsy was performed, and the patient received radiotherapy after vulvar surgery.
  • CONCLUSIONS: Vulvar sweat gland carcinoma is a very rare entity.
  • The vulvar tumor size and inguinal lymph nodes metastasis will influence the prognosis, with pathologic differentiation and surgical margin status being the probable prognostic factors.
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymphatic Metastasis. Middle Aged. Prognosis. Retrospective Studies. Vulva

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  • (PMID = 20606537.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Lopes G, DeCesare T, Ghurani G, Vincek V, Jorda M, Glück S, Silva O: Primary ectopic breast cancer presenting as a vulvar mass. Clin Breast Cancer; 2006 Aug;7(3):278-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary ectopic breast cancer presenting as a vulvar mass.
  • Rarely, its occurrence has been described in the vulva.
  • We report a patient who developed primary adenocarcinoma of ectopic breast tissue in such a location and present a review of the pertinent medical literature.
  • [MeSH-major] Adenocarcinoma / diagnosis. Breast. Breast Neoplasms / diagnosis. Choristoma / diagnosis. Neoplasms, Hormone-Dependent / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans


23. O'Neill CJ, McCluggage WG: p16 expression in the female genital tract and its value in diagnosis. Adv Anat Pathol; 2006 Jan;13(1):8-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p16 expression in the female genital tract and its value in diagnosis.
  • In cervical glandular lesions, p16 is useful, as part of a panel, in the distinction between adenocarcinoma in situ (diffusely positive) and benign mimics, including tuboendometrial metaplasia and endometriosis, which are usually p16-negative or focally positive. p16 may be used, in combination with other markers, to distinguish between a cervical adenocarcinoma (diffuse positivity) and an endometrioid-type endometrial adenocarcinoma (negative or focally positive).
  • In the vulva, p16 is positive in HPV-associated vulval intraepithelial neoplasia (VIN) but negative in VIN not associated with HPV.
  • In the uterus, p16 positivity is more common and widespread in leiomyosarcomas than leiomyomas, and this may be a useful aid to diagnosis, although problematic uterine smooth muscle neoplasms have not been extensively studied.
  • Metastatic cervical adenocarcinomas in the ovary are usually diffusely p16-positive, and because these may closely mimic a primary ovarian endometrioid or mucinous adenocarcinoma, this may be a valuable diagnostic aid, although p16 expression in primary ovarian adenocarcinomas of these morphologic subtypes has not been widely investigated.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / analysis. Genital Neoplasms, Female / diagnosis
  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. Biomarkers, Tumor / analysis. Biomarkers, Tumor / genetics. Carcinoma, Small Cell / chemistry. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / genetics. Cystadenocarcinoma, Serous / chemistry. Cystadenocarcinoma, Serous / diagnosis. Cystadenocarcinoma, Serous / genetics. Diagnosis, Differential. Endometrial Neoplasms / chemistry. Endometrial Neoplasms / diagnosis. Endometrial Neoplasms / genetics. Female. Genes, p16. Genitalia, Female / chemistry. Genitalia, Female / physiopathology. Humans. Immunohistochemistry. Ovarian Neoplasms / chemistry. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / genetics. Tumor Suppressor Proteins / analysis. Tumor Suppressor Proteins / genetics. Uterine Cervical Neoplasms / chemistry. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / genetics. Uterine Neoplasms / chemistry. Uterine Neoplasms / diagnosis. Uterine Neoplasms / genetics. Vulvar Neoplasms / chemistry. Vulvar Neoplasms / classification. Vulvar Neoplasms / diagnosis. Vulvar Neoplasms / genetics

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  • (PMID = 16462152.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 65
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24. Batashki I, Amaliev I, Markova D, Amaliev G, Milchev N: [Ovarian cancer with metastatic lesion in the vagina (foetus papiraceus)]. Akush Ginekol (Sofiia); 2009;48(3):49-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Very rarely it metastasizes to cervix, vulva and vagina; this type of metastases present a diagnostic challenge to the gynecologist and pathologist.
  • [MeSH-major] Adenocarcinoma / pathology. Ovarian Neoplasms / pathology. Vagina / pathology. Vaginal Neoplasms / secondary

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  • (PMID = 20198766.001).
  • [ISSN] 0324-0959
  • [Journal-full-title] Akusherstvo i ginekologii︠a︡
  • [ISO-abbreviation] Akush Ginekol (Sofiia)
  • [Language] bul
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Bulgaria
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25. Simon SK, Bolanca IK, Sentija K, Kukura V, Valetić J, Skrtić A: Vulvar Paget's disease--a case report. Coll Antropol; 2010 Jun;34(2):649-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vulvar Paget's disease--a case report.
  • Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma.
  • It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women.
  • Occasionally, single anaplastic Paget's cells can be found on the vulvar smears which make cytological diagnosis of the disease possible.
  • We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago.
  • During the standard gynecological examination the vulvar smear was taken for cytological evaluation.
  • Accordingly, cytological diagnosis vulvar intraepithelial neoplasia (VIN III) with differential diagnosis of vulvar Paget's disease was made.
  • The pathological verification supported the diagnosis of MP and an immunohistochemistry panel confirmed type III of Paget's disease and an evaluation of bladder was suggested.
  • [MeSH-major] Paget Disease, Extramammary / pathology. Vulvar Diseases / pathology
  • [MeSH-minor] Cervix Uteri / pathology. Female. Humans. Keratin-7 / analysis. Kidney Transplantation. Liver Transplantation. Middle Aged. Vaginal Smears. Vulva / pathology

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  • (PMID = 20698146.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Keratin-7
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26. Rahman MT, Afroze N, Tahmin T, Nipa NN, Faisal RH, Choudhury SR: Light microscopic study of cervical smear in a tertiary hospital at Dhaka. Mymensingh Med J; 2010 Apr;19(2):208-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Out of these 798 smears examined light microscopically 274(34.34%) was normal, 453(54.26%) were inflammatory smear, 49(6.14%) showed Gardrenella, 9(1.13%) revealed the presence of Candida, 3(0.38%) showed Trichomonial infection, 6(0.76%) showed the presence of atypical cells (5ASCUS, 1 CIN) and 2(0.26%) were positive for malignancy, (1 adenocarcinoma, 1 squamous cell carcinoma).
  • The common presenting complains of these women Menorrhagia (17.92%), Menopausal Symptoms (17.42%), Lower Abdominal pain (15.78%), White PV discharge (15.78%), Dysmenorrhoea (7.52%), Pruritus/Itching vulva (7.14%), Prolapse (4.39%), Fibroid (2.01%), Infertility (1.13%), Post coital bleeding (0.75%) respectively.
  • Pap's smear is reconfirmed as an established major screening tool for diagnosis of different cervical lesions.

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  • (PMID = 20395913.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Bangladesh
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27. Mentzel T, Reisshauer S, Rütten A, Hantschke M, Soares de Almeida LM, Kutzner H: Cutaneous clear cell myomelanocytic tumour: a new member of the growing family of perivascular epithelioid cell tumours (PEComas). Clinicopathological and immunohistochemical analysis of seven cases. Histopathology; 2005 May;46(5):498-504
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Perivascular epithelioid cell tumours (so-called PEComas) are rare and recently delineated neoplasms occurring in the lung, kidney, pancreas, uterus, falciform ligament, vulva, heart, prostate and soft tissues.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Epithelioid Cells / pathology. Melanocytes / pathology. Muscle Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, Neoplasm. DNA-Binding Proteins / analysis. Female. Forearm. Humans. Immunohistochemistry. Knee. Leg. Melanoma-Specific Antigens. Microphthalmia-Associated Transcription Factor. Middle Aged. Neoplasm Proteins / analysis. Transcription Factors / analysis

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  • (PMID = 15842631.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA-Binding Proteins; 0 / MITF protein, human; 0 / Melanoma-Specific Antigens; 0 / Microphthalmia-Associated Transcription Factor; 0 / Neoplasm Proteins; 0 / Transcription Factors
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28. Temkin SM, Hellman M, Lee YC, Abulafia O: Surgical resection of vulvar metastases of endometrial cancer: a presentation of two cases. J Low Genit Tract Dis; 2007 Apr;11(2):118-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical resection of vulvar metastases of endometrial cancer: a presentation of two cases.
  • CASE 1: A 63-year-old patient presented 7 years after treatment of endometrial cancer with a vulvar lesion and groin mass.
  • After radical wide excision of her vulvar mass and bilateral groin dissection, final pathology revealed that the mass was consistent with recurrent endometrial cancer.
  • CONCLUSIONS: Uncommon sites of recurrence of endometrial cancer may include the vulva.
  • [MeSH-major] Adenocarcinoma / surgery. Endometrial Neoplasms / pathology. Gynecologic Surgical Procedures. Vulvar Neoplasms / surgery

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  • (PMID = 17415118.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Lam C, Funaro D: Extramammary Paget's disease: Summary of current knowledge. Dermatol Clin; 2010 Oct;28(4):807-26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy accounting for approximately 1% of vulvar cancers.
  • Controversies exist in the literature regarding many aspects of this condition including the prevalence of concurrent vulvar adenocarcinoma or invasive EMPD, association with regional and distant cancers, and recurrence rates following surgical excision.
  • [MeSH-major] Paget Disease, Extramammary / diagnosis. Paget Disease, Extramammary / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy. Vulvar Neoplasms / diagnosis. Vulvar Neoplasms / therapy
  • [MeSH-minor] Diagnosis, Differential. Female. Gastrointestinal Neoplasms / diagnosis. Humans. Immunohistochemistry. Male. Neoplasms, Multiple Primary / diagnosis. Prognosis. Urogenital Neoplasms / diagnosis

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20883922.001).
  • [ISSN] 1558-0520
  • [Journal-full-title] Dermatologic clinics
  • [ISO-abbreviation] Dermatol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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30. Fernandez-Flores A, Pol A, Juanes F, Crespo LG: Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies. Med Mol Morphol; 2007 Dec;40(4):212-7
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  • The patient did not present any symptoms, and the only complaint was the nodule, which was resected for diagnosis.
  • Owing to the cribriform pattern of the tumor, we also looked for a metastasis from other sites, mainly breast, vulva, and salivary glands, but all these were clinically excluded.
  • In spite of these characteristics, which are, for some authors, indicative of an apocrine phenotype, the immunohistochemical study revealed some differences with the profile that has been described in cases of apocrine adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / immunology. Adenocarcinoma / pathology. Antibodies, Neoplasm / immunology. Skin Neoplasms / immunology. Skin Neoplasms / pathology

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  • (PMID = 18085381.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm
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31. Takei H, Powell SZ: Tumor-to-tumor metastasis to the central nervous system. Neuropathology; 2009 Jun;29(3):303-8
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  • We report herein two such cases of metastasis from pulmonary adenocarcinoma and malignant melanoma (MM) of vulva, respectively.
  • Case 1: a 69-year-old female smoker who had a history of right upper lobectomy of lung for adenocarcinoma presented with a headache and altered mental status, and was found to have a left temporal contrast-enhancing mass with massive surrounding edema on MRI.
  • The resection specimen revealed foci of metastatic adenocarcinoma within a microcystic meningioma.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Aged. Brain / pathology. Brain / surgery. Fatal Outcome. Female. Humans. Immunohistochemistry. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Magnetic Resonance Imaging. Melanoma / pathology. Melanoma / surgery. Treatment Outcome. Vulvar Neoplasms / pathology. Vulvar Neoplasms / surgery

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  • (PMID = 18647266.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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32. Staiano JJ, Wong L, Butler J, Searle AE, Barton DP, Harris PA: Flap reconstruction following gynaecological tumour resection for advanced and recurrent disease--a 12 year experience. J Plast Reconstr Aesthet Surg; 2009 Mar;62(3):346-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The predominant site of the primary tumour was vulva, accounting for 83% of the cases, with cervix, ovary, vagina and endometrium making up the remainder.
  • Squamous cell carcinoma was the most common histological type, accounting for 71% of cases, with adenocarcinoma, Paget disease, leiomyosarcoma, melanoma and basosquamous carcinoma making up the remainder.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Genital Neoplasms, Female / surgery. Gynecologic Surgical Procedures / methods. Surgical Flaps / blood supply
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Middle Aged. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Surgical Wound Infection / prevention & control. Treatment Outcome

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  • (PMID = 18784004.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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33. Brown HM, Wilkinson EJ: Cytology of secondary vulvar Paget's disease of urothelial origin: a case report. Acta Cytol; 2005 Jan-Feb;49(1):71-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytology of secondary vulvar Paget's disease of urothelial origin: a case report.
  • BACKGROUND: Primary cutaneous Paget's disease of the vulva is an intraepithelial adenocarcinoma most likely arising from a cutaneous stem cell with sweat gland epithelial differentiation or can be of sweat gland origin.
  • Primary vulvar Paget's disease, however, can be mimicked by an internal noncutaneous neoplasm htat has extended to secondarily involve the vulva.
  • Most commonly, this is due to an anal or rectal adenocarcinoma or a urothelial carcinoma.
  • These malignancies may be detected in a vaginal or vulvar cytologic smear.
  • CASE: An 81-year-old woman with a past history of urothelial carcinoma in situ of the bladder presented severalyears subsequent to treatment for bladder cancer with extensive vulvar and vaginal disease, clinically interpreted as primary vulvar Paget's disease involving the vagina.
  • Subsequent investigation of her bladder showed recurrent urothelial carcinoma in situ with extensive spread to the vagina and vulva, simulating primary cutaneous vulvar Paget's disease.
  • CONCLUSION: It is important to recognize secondary vulvar Paget's disease, although uncommon, because of the difference in therapy for primary and secondary vulvar Paget's disease.
  • Certain cytologic characteristics in a vaginal or vulvar smear in a patient with suspected vulvar Paget's disease may aid in distinguishing them.
  • [MeSH-major] Paget Disease, Extramammary / pathology. Paget Disease, Extramammary / secondary. Urothelium / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 15717759.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Gadducci A, Cionini L, Romanini A, Fanucchi A, Genazzani AR: Old and new perspectives in the management of high-risk, locally advanced or recurrent, and metastatic vulvar cancer. Crit Rev Oncol Hematol; 2006 Dec;60(3):227-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Old and new perspectives in the management of high-risk, locally advanced or recurrent, and metastatic vulvar cancer.
  • During the last decades there has been a continuing evolution in the surgical approach of squamous cell carcinoma of the vulva that has been traditionally treated with radical vulvectomy and bilateral inguinal-femoral lymphadenectomy.
  • Patients with T1 tumour are usually treated with radical local excision, if the lesion is unifocal and the remainder of the vulva is normal.
  • Locally advanced squamous cell carcinoma of the vulva has been long surgically treated with en-block radical vulvectomy and bilateral inguinal-femoral lymphadenectomy plus partial resection of urethra, vagina or anum, or by exenteration, with severe postsurgical complications, poor quality of life, and unsatisfactory survival rates.
  • Surgery is the primary treatment also for vulvar malignancies other than squamous cell carcinoma, whereas the clinical usefulness of adjuvant irradiation or chemotherapy is still to be defined.
  • Primary chemoradiation can be also used for advanced carcinoma of the Bartholin gland or for advanced adenocarcinoma associated with extramammary Paget's disease.
  • The drugs used for chemotherapy of metastatic melanomas or sarcomas of the vulva are the same employed for the melanomas or sarcomas developed in other sites.
  • [MeSH-major] Vulvar Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Neoplasm Metastasis. Recurrence

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  • (PMID = 16945551.001).
  • [ISSN] 1040-8428
  • [Journal-full-title] Critical reviews in oncology/hematology
  • [ISO-abbreviation] Crit. Rev. Oncol. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 167
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35. Chang YM, Hsu KF, Chang SC: Extra-mammary Paget's disease of the scrotum and penis: a case report. Acta Chir Belg; 2009 Nov-Dec;109(6):808-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is an intra-epithelial adenocarcinoma that involves the area rich in apocrine glands.
  • The most common affected lesions are the vulva and perianal region, followed by the axillae and inguinoscrotal area.
  • The diagnosis and treatment are discussed.

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  • (PMID = 20184077.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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36. Agrawal A, Yau A, Magliocco A, Chu P: Cutaneous metastatic disease in cervical cancer: a case report. J Obstet Gynaecol Can; 2010 May;32(5):467
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CASE: A 66-year-old postmenopausal woman with a diagnosis of stage IVa cervical carcinoma was treated with radical concurrent chemotherapy and radiation.
  • The cutaneous metastases progressed rapidly to involve the inguinal regions, vulva, and perineum.
  • In the majority of these cases, patients presented within 10 years of initial diagnosis and died within a mean of 8.5 months from cutaneous metastasis.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Skin Neoplasms / secondary. Uterine Cervical Neoplasms / pathology


37. Illanes D, Broman J, Meyer B, Kredentser D, McElrath T, Timmins P 3rd: Verrucous carcinoma of the endometrium: case history, pathologic findings, brief review of literature and discussion. Gynecol Oncol; 2006 Aug;102(2):375-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A defined disease of the oral cavity, larynx, esophagus, skin, vulva, vagina and cervix.
  • But a verrucous carcinoma arising from the endometrium without evidence of cervical malignancy or endometrial adenocarcinoma is extremely rare.

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  • (PMID = 16529798.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Spiliopoulos D, Spiliopoulos M, Dandolu V, Mastrogiannis D: Vulvar and breast Paget's disease with synchronous underlying cancer: a unique association. Arch Gynecol Obstet; 2009 Aug;280(2):313-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vulvar and breast Paget's disease with synchronous underlying cancer: a unique association.
  • BACKGROUND: We report a unique case of Paget's disease of vulva and breast.
  • Sequentially the patient had invasive ductal carcinoma of the breast, 5 years later was diagnosed with vulvar Paget's with underlying adenocarcinoma and after another 2 years was diagnosed with Paget's disease of the breast.
  • Five years later and after complaints of longstanding vulvar pruritus, the patient was diagnosed with vulvar Paget's disease and treated with simple vulvectomy, which revealed a concurrent underlying adenocarcinoma.
  • Subsequently there was recurrence of vulvar malignancy and wide local excision was performed.
  • Seven years after the initial diagnosis of the breast cancer, a biopsy of a left areolar red, ulcerated lesion revealed Paget's disease of the breast.
  • [MeSH-major] Breast Neoplasms / pathology. Neoplasm Recurrence, Local. Neoplasms, Second Primary. Paget Disease, Extramammary / pathology. Paget's Disease, Mammary / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 19112575.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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39. Perez-Torres M, Valle BL, Maihle NJ, Negron-Vega L, Nieves-Alicea R, Cora EM: Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells. Exp Cell Res; 2008 Oct 1;314(16):2907-18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells.
  • Soluble isoforms of the epidermal growth factor receptor (sEGFR) previously have been identified in the conditioned culture media (CCM) of the vulvar adenocarcinoma cell line, A431 and within exosomes of the keratinocyte cell line HaCaT.
  • Our results further suggest that when proteolytic shedding of EGFR does occur, it is correlated with a highly malignant phenotype.

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  • (PMID = 18687326.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 096297; United States / NCI NIH HHS / CA / CA73859; United States / NCI NIH HHS / CA / CA85133; United States / NCRR NIH HHS / RR / P20RR016439; United States / NIGMS NIH HHS / GM / S06GM08225
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptides; 0 / Protease Inhibitors; 0 / Protein Isoforms; 0 / Transforming Growth Factor alpha; 0 / pervanadate; 3WHH0066W5 / Vanadates; 62229-50-9 / Epidermal Growth Factor; 6283-24-5 / 4-aminophenylmercuriacetate; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.13 / Protein Kinase C; NI40JAQ945 / Tetradecanoylphorbol Acetate; OSX88361UX / Phenylmercuric Acetate
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40. Barnhill D, Smith M, Spears R, Ruiz B, Nolan T: Granular cell tumor of the vulva. J La State Med Soc; 2010 Jul-Aug;162(4):199-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumor of the vulva.
  • [MeSH-major] Adenocarcinoma / surgery. Vulvar Neoplasms / surgery

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  • (PMID = 20882811.001).
  • [ISSN] 0024-6921
  • [Journal-full-title] The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
  • [ISO-abbreviation] J La State Med Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. North J, Perez D, Fentiman G, Sykes P, Dempster A, Pearse M: Primary breast cancer of the vulva: case report and literature review. Aust N Z J Obstet Gynaecol; 2007 Feb;47(1):77-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary breast cancer of the vulva: case report and literature review.
  • [MeSH-major] Adenocarcinoma / pathology. Breast. Breast Neoplasms / pathology. Choristoma / pathology. Mammary Glands, Human / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 17261107.001).
  • [ISSN] 0004-8666
  • [Journal-full-title] The Australian & New Zealand journal of obstetrics & gynaecology
  • [ISO-abbreviation] Aust N Z J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 12
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42. Mariappan MR, Lagera JE, Fadare O, Sibley RK: A 69-year-old woman with a vulvar lesion. Phyllodes tumor of the vulva. Arch Pathol Lab Med; 2006 Jan;130(1):e11-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A 69-year-old woman with a vulvar lesion. Phyllodes tumor of the vulva.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Aged. Choristoma / diagnosis. Diagnosis, Differential. Female. Humans. Mixed Tumor, Mullerian / diagnosis. Uterine Cervical Neoplasms / diagnosis

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  • (PMID = 16390249.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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