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Items 1 to 69 of about 69
1. Gangopadhyay M, Raha K, Sinha SK, De A, Bera P, Pati S: Endodermal sinus tumor of the vagina in children: a report of two cases. Indian J Pathol Microbiol; 2009 Jul-Sep;52(3):403-4
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  • [Title] Endodermal sinus tumor of the vagina in children: a report of two cases.
  • Malignant tumors of the vagina in infants and children are rare, with primary germ cell tumor (endodermal sinus tumor [EST]) being rarer, which carries a dismal prognosis.
  • This tumor is often clinically mistaken as botryoid rhabdomyosarcoma and, on histopathological examination, is often misdiagnosed as clear cell adenocarcinoma.
  • Two cases of EST of the vagina in infants aged 9 and 17 months are reported.
  • Both the patients presented with bleeding per vagina and clinically and by ultrasonography were diagnosed as sarcoma botryoides.
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / pathology. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / pathology
  • [MeSH-minor] Fatal Outcome. Female. Hemorrhage / etiology. Histocytochemistry. Humans. Infant. Treatment Outcome. Vagina / pathology. alpha-Fetoproteins / analysis

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  • (PMID = 19679975.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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2. Karasavvidou F, Potamianos SP, Barbanis S, Stathakis E, Psychos A, Kapsoritakis AN, Koukoulis G: Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies. World J Gastroenterol; 2007 Dec 7;13(45):6109-11
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  • [Title] Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies.
  • It has also been found in many other sites such as the gastrointestinal tract, pancreas, liver, lymph nodes, skin, respiratory tract, adrenal gland, vagina and brain.
  • Biopsies of the ascending colon mass confirmed the diagnosis of adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Colonic Neoplasms / complications. Malacoplakia / complications

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  • (PMID = 18023111.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4250902
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3. Zeeshan-ud-din, Ahsan A: Vaginal clear cell adenocarcinoma with associated Müllerian duct anomalies, renal agenesis and situs inversus: report of a case with no known in-utero exposure with diethyl stilboestrol. J Pak Med Assoc; 2009 Aug;59(8):568-70
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  • [Title] Vaginal clear cell adenocarcinoma with associated Müllerian duct anomalies, renal agenesis and situs inversus: report of a case with no known in-utero exposure with diethyl stilboestrol.
  • A 27 year old female presented with two months history of continuous vaginal bleeding.
  • On evaluation, she was diagnosed as a case of vaginal clear cell adenocarcinoma (VCCA) along with associated Müllerian duct anomalies including didelphys uterus with double vagina; left sided renal agenesis and situs inversus.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Kidney / abnormalities. Mullerian Ducts / pathology. Situs Inversus / diagnosis. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Carcinogens / toxicity. Diethylstilbestrol / toxicity. Female. Humans. Pregnancy. Prenatal Exposure Delayed Effects. Uterus / abnormalities. Vagina / abnormalities


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4. Paczos TA, Ackers S, Odunsi K, Lele S, Mhawech-Fauceglia P: Primary vaginal adenocarcinoma arising in vaginal adenosis after CO2 laser vaporization and 5-fluorouracil therapy. Int J Gynecol Pathol; 2010 Mar;29(2):193-6
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  • [Title] Primary vaginal adenocarcinoma arising in vaginal adenosis after CO2 laser vaporization and 5-fluorouracil therapy.
  • Subsequent vaginal smears revealed high-grade vaginal intraepithelial neoplasia (VAIN III) on Pap smear with positive human papilloma virus (HPV) testing.
  • Over the course of 2 years, the patient underwent 2 CO(2) laser vaporization procedures of the upper vagina and intermittent 5-fluorouracil therapy.
  • A biopsy performed at the time of the second laser procedure revealed endocervical-type well-differentiated adenocarcinoma, associated with VAIN III.
  • The vaginectomy specimen showed residual adenocarcinoma associated with VAIN-III and extensive vaginal adenosis with free resection margins.
  • This is the second reported case in the literature of adenocarcinoma arising in vaginal adenosis after 5-fluorouracil.
  • Herein, we highlight these important findings and shed some light on the pathogenesis of vaginal adenosis and the subsequent development of vaginal adenocarcinoma.

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  • (PMID = 20173507.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / T32 CA108456
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; U3P01618RT / Fluorouracil
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5. Bifulco G, Mandato VD, Mignogna C, Giampaolino P, Di Spiezio Sardo A, De Cecio R, De Rosa G, Piccoli R, Radice L, Nappi C: A case of mesonephric adenocarcinoma of the vagina with a 1-year follow-up. Int J Gynecol Cancer; 2008 Sep-Oct;18(5):1127-31
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  • [Title] A case of mesonephric adenocarcinoma of the vagina with a 1-year follow-up.
  • Mesonephric adenocarcinoma deriving from remnants of vaginal mesonephric ducts is one of the rarest tumors of the female genital tract with only three cases reported till date in international literature.
  • Differential diagnosis from other aggressive tumors is complex and controversies exist in the literature regarding the biological behavior, prognosis, and optimal management strategies of these tumors.
  • A well-capsulated mesonephric adenocarcinoma in a background of vaginal mesonephric remnants was diagnosed.
  • In spite of the aggressive biological behavior attributed in literature to mesonephric carcinomas, which is probably due to the complex differential diagnosis with other müllerian tumors, the favorable course of our patient further supports the hypothesis that malignant mesonephric carcinomas may not behave aggressively and that radical surgery alone may be curative.
  • [MeSH-major] Adenocarcinoma / pathology. Mesonephroma / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 18028380.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Nomoto K, Hori T, Kiya C, Fukuoka J, Nakashima A, Hidaka T, Saito S, Mikami Y, Tsuneyama K, Takano Y: Endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from endometriosis after hysterectomy. Pathol Int; 2010 Sep;60(9):636-41
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  • [Title] Endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from endometriosis after hysterectomy.
  • Primary endometrioid adenocarcinoma rarely occurs in the vagina.
  • Occasionally, endometrioid adenocarcinoma has a microglandular pattern.
  • Herein, a case of primary endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from pre-existing endometriosis long after a hysterectomy, is described.
  • A 57-year-old postmenopausal woman developed a vaginal discharge over one decade after undergoing a hysterectomy.
  • Microscopic examination of the vaginal smear and a biopsy specimen demonstrated an atypical glandular proliferation composed of columnar cells with occasional intracytoplasmic mucin and bland nuclear morphology, showing microcysts and numerous neutrophils within and around cysts.
  • A portion of residual endometrioid adenocarcinoma was identified adjacent to foci of endometriosis in the vaginectomy specimen.
  • Pathologists are encouraged to be aware of the occurrence of endometrioid adenocarcinoma associated with endometriosis in the vaginal stump after hysterectomy, and microglandular morphology which might be a source of misinterpretation.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Endometriosis / surgery. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / pathology


7. Erşahin C, Huang M, Potkul RK, Hammadeh R, Salhadar A: Mesonephric adenocarcinoma of the vagina with a 3-year follow-up. Gynecol Oncol; 2005 Dec;99(3):757-60
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  • [Title] Mesonephric adenocarcinoma of the vagina with a 3-year follow-up.
  • BACKGROUND: Mesonephric adenocarcinoma of the vagina is exceedingly rare, with only one well-documented case in the literature.
  • Little is known regarding clinical presentation, pathological characteristics, therapy, or prognosis of the vaginal mesonephric adenocarcinoma.
  • CASE: A 55-year-old woman presented with a polypoid mass at the right vaginal apex, extending to the right paravaginal tissue.
  • The tumor was an adenocarcinoma with ductal and tubular pattern arising in a background of mesonephric remnants.
  • CONCLUSION: We report the second case of mesonephric adenocarcinoma of the vagina with metastasis to the right fallopian tube and to one paravaginal lymph node.
  • [MeSH-major] Adenocarcinoma / pathology. Mesonephroma / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 16137744.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Verloop J, van Leeuwen FE, Helmerhorst TJ, van Boven HH, Rookus MA: Cancer risk in DES daughters. Cancer Causes Control; 2010 Jul;21(7):999-1007
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  • [Title] Cancer risk in DES daughters.
  • OBJECTIVE: We examined long-term risk of cancer in women exposed to diethylstilbestrol (DES) in utero.
  • Cancer incidence was assessed through linkage with the Dutch pathology database (PALGA) and the Netherlands Cancer Registry and compared with the Dutch female population.
  • No overall increased risk of cancer was found (standardized incidence ratio [SIR] = 1.01; 95% confidence interval [CI] = 0.91, 1.13).
  • The risk of clear cell adenocarcinoma of the vagina and cervix (CCA) was statistically significantly increased (SIR = 24.23; 95% CI = 8.89, 52.74); the elevated risk persisted above 40 years of age.
  • No excess risks were found for other sites, including breast cancer.
  • CONCLUSIONS: Except for an elevated risk of CCA, persisting at older ages, and an increased risk of melanoma at young ages, we found no increased risk of cancer.
  • Longer follow-up is warranted to examine cancer risk at ages when cancer occurs more frequently.
  • [MeSH-major] Adenocarcinoma, Clear Cell / epidemiology. Diethylstilbestrol / adverse effects. Nuclear Family. Vaginal Neoplasms / epidemiology

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  • (PMID = 20204493.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Estrogens, Non-Steroidal; 731DCA35BT / Diethylstilbestrol
  • [Other-IDs] NLM/ PMC2883094
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9. Renaud MC, Plante M, Grégoire J, Roy M: Primitive clear cell carcinoma of the vagina treated conservatively. J Obstet Gynaecol Can; 2009 Jan;31(1):54-6
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  • [Title] Primitive clear cell carcinoma of the vagina treated conservatively.
  • BACKGROUND: Clear cell adenocarcinoma of the vagina is rare tumour that is usually treated aggressively.
  • We report a case of clear cell adenocarcinoma in which conservative treatment using new technology was successfully completed.
  • CASE: A 19-year-old woman with a biopsy proven clear cell adenocarcinoma of the vagina was referred to our clinic.
  • Colposcopic examination and pelvic MRI confirmed a superficial vaginal lesion.
  • Fertility-sparing surgery, comprising radical local vaginal excision, laparoscopy, sentinel node mapping, pelvic node dissection, and omentectomy, was planned.
  • [MeSH-major] Adenocarcinoma, Clear Cell / surgery. Fertility. Vaginal Neoplasms / surgery

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  • (PMID = 19208284.001).
  • [ISSN] 1701-2163
  • [Journal-full-title] Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC
  • [ISO-abbreviation] J Obstet Gynaecol Can
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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10. Shah C, Pizer E, Veljovich DS, Drescher CW, Peters WA 3rd, Paley PJ: Clear cell adenocarcinoma of the vagina in a patient with vaginal endometriosis. Gynecol Oncol; 2006 Dec;103(3):1130-2
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  • [Title] Clear cell adenocarcinoma of the vagina in a patient with vaginal endometriosis.
  • Physical examination revealed a 2-cm polypoid lesion at the posterior vaginal apex, which was found to be a moderately differentiated invasive adenocarcinoma.
  • Final pathology at the time of definitive surgery demonstrated a clear cell adenocarcinoma of the vagina arising in vaginal endometriosis.
  • CONCLUSION: Vaginal endometriosis may lead to the development of cancer.
  • We report a case of clear cell malignancy arising in vaginal endometriosis, adding to only seven cases previously reported.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Endometriosis / diagnosis. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged


11. Staats PN, Clement PB, Young RH: Primary endometrioid adenocarcinoma of the vagina: a clinicopathologic study of 18 cases. Am J Surg Pathol; 2007 Oct;31(10):1490-501
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  • [Title] Primary endometrioid adenocarcinoma of the vagina: a clinicopathologic study of 18 cases.
  • Vaginal adenocarcinoma is the second most common primary cancer of the vagina, yet there has been very little study of most subtypes other than clear cell carcinoma.
  • We reviewed 18 cases of primary vaginal endometrioid adenocarcinoma, in our experience the second most common subtype.
  • Most presented with vaginal bleeding, and had had a prior hysterectomy.
  • The tumors were at the vaginal apex in 10 cases, in the posterior wall in 3, the lateral wall in 3, and the anterior wall in 1.
  • On microscopic examination, each of the tumors had a pure or predominant component of typical endometrioid adenocarcinoma.
  • Vaginal endometriosis was identified in 14 cases, and is important in indicating a primary vaginal tumor, rather than secondary spread from the endometrium.
  • Other subtypes of adenocarcinoma (such as serous when the tumor has a papillary pattern) and atypical forms of endometriosis, including polypoid endometriosis, are the most common other differential diagnostic considerations.
  • [MeSH-major] Carcinoma, Endometrioid / pathology. Vaginal Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Combined Modality Therapy. Cystadenocarcinoma, Serous / diagnosis. Diagnosis, Differential. Endometriosis / complications. Endometriosis / pathology. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Treatment Outcome

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  • (PMID = 17895749.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. van Dijck JA, Doorduijn Y, Bulten JH, Verloop J, Massuger LF, Kiemeney BA: [Vaginal and cervical cancer due to diethylstilbestrol (DES); end epidemic]. Ned Tijdschr Geneeskd; 2009;153:A366
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  • [Title] [Vaginal and cervical cancer due to diethylstilbestrol (DES); end epidemic].
  • [Transliterated title] Vagina- en cervixcarcinoom door diëthylstilbestrol (des). Einde epidemie.
  • OBJECTIVE: To determine the current situation regarding the epidemic of clear cell adenocarcinoma of the vagina and the uterine cervix (CCAC) in relation to the exposure in utero to diethylstilbestrol (DES).
  • METHODS: Patients with CCAC of the uterine cervix or vagina born after 1946 and diagnosed in the period 1969-2005, were identified through the Nationwide network and registry of histo- and cytopathology in the Netherlands and from 2003 onwards through the Netherlands Cancer Registry.
  • For the patients who did not provide consent, only the date of diagnosis and age at diagnosis were known (n = 10).
  • Age at diagnosis varied from 8-54 years (mean: 28 years).
  • The mean age at diagnosis was 24 years for exposed patients compared to 32 years for non-exposed patients.
  • CONCLUSION: Since 2000, the incidence of CCAC of the vagina and cervix has decreased markedly compared to the situation in the 1980s and 1990 s.
  • [MeSH-major] Adenocarcinoma, Clear Cell / epidemiology. Diethylstilbestrol / adverse effects. Uterine Cervical Neoplasms / epidemiology. Vaginal Neoplasms / epidemiology


13. Nagarsheth NP, Harrison M, Kalir T, Rahaman J: Malignant pericardial effusion with cardiac tamponade in a patient with metastatic vaginal adenocarcinoma. Int J Gynecol Cancer; 2006 May-Jun;16(3):1458-61
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  • [Title] Malignant pericardial effusion with cardiac tamponade in a patient with metastatic vaginal adenocarcinoma.
  • Malignant pericardial effusion with cardiac tamponade is a rare manifestation of metastatic gynecological cancer.
  • A 35-year-old female was diagnosed with clear cell adenocarcinoma of the vagina.
  • Metastatic adenocarcinoma of the vagina can present with malignant pericardial effusion with cardiac tamponade.
  • Therefore, gynecologists and gynecological oncologists need to be familiar with the diagnosis and management of this disease process.
  • [MeSH-major] Adenocarcinoma, Clear Cell / secondary. Cardiac Tamponade / etiology. Pericardial Effusion / etiology. Vaginal Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Heart Neoplasms / diagnosis. Heart Neoplasms / secondary. Humans. Pericardiocentesis / methods. Tomography, X-Ray Computed

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  • (PMID = 16803549.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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14. Saitoh M, Hayasaka T, Ohmichi M, Kurachi H, Motoyama T: Primary mucinous adenocarcinoma of the vagina: possibility of differentiating from metastatic adenocarcinomas. Pathol Int; 2005 Jun;55(6):372-5
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  • [Title] Primary mucinous adenocarcinoma of the vagina: possibility of differentiating from metastatic adenocarcinomas.
  • Primary vaginal adenocarcinomas are rare neoplasms.
  • Herein is reported a case of primary vaginal mucinous adenocarcinoma with an interesting mucin profile, presumably arising from a lesion of adenosis in a patient without in utero exposure to diethylstilbesterol (DES).
  • The patient, a 44-year-old woman, had undergone vaginal total hysterectomy 10 years previously for myoma uteri corporis.
  • The histological features of the vaginal intramural tumor found in this patient resembled those of mucinous adenocarcinoma of the endocervical type.
  • Therefore, it was necessary to determine whether or not the tumor was metastatic from an occult cervical adenocarcinoma.
  • However, the adenocarcinoma cells of the present case did not contain sulfomucin at all, being different from most mucinous adenocarcinoma cells of the endocervical type.
  • Moreover, there were foci of adenosis adjacent to the adenocarcinoma foci, which also did not contain sulfomucin.
  • These findings indicate that the mucinous adenocarcinoma arose from vaginal adenosis.
  • Further studies are necessary to investigate whether lack of sulfomucin expression is a characteristic feature of vaginal adenosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Vaginal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Mucin 5AC. Mucin-1 / analysis. Mucin-2. Mucin-6. Mucins / analysis. Neoplasm Metastasis. Vagina / chemistry. Vagina / pathology

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  • (PMID = 15943796.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucin-6; 0 / Mucins
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15. Tjalma WA, Colpaert CG: Primary vaginal adenocarcinoma of intestinal type arising from a tubulovillous adenoma. Int J Gynecol Cancer; 2006 May-Jun;16(3):1461-5
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  • [Title] Primary vaginal adenocarcinoma of intestinal type arising from a tubulovillous adenoma.
  • Enteric or intestinal-type neoplasms of the vagina are extremely rare.
  • On clinical examination, a lesion on the posterior vaginal wall was noticed.
  • Biopsy revealed an adenocarcinoma of the intestinal type, with a small remnant of a villous adenoma.
  • This led to the conclusion that the lesion was a primary intestinal-type adenocarcinoma of the vagina that had arisen from a vaginal villous adenoma.
  • It is important to be aware of this tumor type and to distinguish them from metastatic colorectal adenocarcinoma in order to plan appropriate treatment.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Intestinal Neoplasms / diagnosis. Middle Aged

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  • (PMID = 16803550.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Nasu K, Kai K, Matsumoto H, Mori C, Takai N, Narahara H: Primary mucinous adenocarcinoma of the vagina. Eur J Gynaecol Oncol; 2010;31(6):679-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mucinous adenocarcinoma of the vagina.
  • PURPOSE: Primary mucinous adenocarcinoma of the vagina is a rare disease which is characterized by aggressiveness and poor prognosis because of its rapid growth and recurrence, its frequent distant metastases, and its relative resistance to conventional treatment modalities including surgery, radiotherapy, and chemotherapy.
  • We report a case of advanced stage primary mucinous adenocarcinoma of the vagina that showed a highly aggressive course and resistance to combination chemotherapy with paclitaxel and carboplatin.
  • CASE: A 46-year-old multigravid Japanese woman was admitted to our hospital to be treated for Stage IVb primary mucinous adenocarcinoma of the vagina.
  • CONCLUSION: Because of its rarity, little is known about the behavior of primary mucinous adenocarcinoma of the vagina.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / therapy. Vaginal Neoplasms / pathology. Vaginal Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Fatal Outcome. Female. Humans. Middle Aged. Neoplasm Staging. Pelvic Exenteration. Vagina / pathology

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  • (PMID = 21319516.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
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17. Ditto A, Martinelli F, Carcangiu ML, Hanozet F, Solima E, Barisella M, Cerrotta A, Raspagliesi F: Incidental diagnosis of primary vaginal adenocarcinoma of intestinal type: a case report and review of the literature. Int J Gynecol Pathol; 2007 Oct;26(4):490-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidental diagnosis of primary vaginal adenocarcinoma of intestinal type: a case report and review of the literature.
  • Primary vaginal adenocarcinoma of intestinal type is a rare malignant gynecologic disease.
  • A 53-year-old woman was admitted to our institution with a diagnosis of endometrial adenocarcinoma.
  • A physical examination revealed a 2-cm polypoid lesion of the vagina.
  • The patient underwent surgery for endometrial cancer and wedge resection of the vaginal lesion.
  • The diagnosis of primary vaginal adenocarcinoma of intestinal type was obtained after standard and immunohistochemical analyses of the specimen.
  • No endometrial cancer was detected in the specimen.
  • Extensive radiological investigations and careful immunohistochemical analysis of the specimen are needed for a correct diagnosis of vaginal adenocarcinoma of intestinal type.
  • [MeSH-major] Adenocarcinoma / pathology. Vaginal Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Endometrial Neoplasms / pathology. Female. Gynecologic Surgical Procedures. Humans. Immunohistochemistry. Incidental Findings. Intestinal Neoplasms / pathology. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Radiotherapy

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  • (PMID = 17885503.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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18. Matsuo K, Chi DS, Eno ML, Im DD, Rosenshein NB: Vulvar mucinous adenocarcinoma associated with Crohn's disease: report of two cases. Gynecol Obstet Invest; 2009;68(4):276-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vulvar mucinous adenocarcinoma associated with Crohn's disease: report of two cases.
  • BACKGROUND: Rectovaginal fistula in long-standing Crohn's disease is possibly associated with malignant transformation to mucinous adenocarcinoma of the vagina.
  • However, there have been no previously reported cases documenting vulvar cancer in association with rectovaginal fistula in Crohn's disease.
  • We report 2 cases of vulvar mucinous adenocarcinoma associated with Crohn's disease.
  • Further workup revealed metastatic vulvar mucinous adenocarcinoma.
  • Biopsy showed mucinous adenocarcinoma.
  • CONCLUSION: Vulvar lesions or symptoms in the setting of rectovaginal fistula in Crohn's disease are an important clinical feature and the possible development of vulvar cancer should be considered.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Crohn Disease / complications. Rectovaginal Fistula / complications. Vulvar Neoplasms / etiology
  • [MeSH-minor] Adult. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bevacizumab. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Lung Neoplasms / drug therapy. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Middle Aged. Organoplatinum Compounds / administration & dosage. Positron-Emission Tomography

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  • [Copyright] 2009 S. Karger AG, Basel.
  • (PMID = 19828998.001).
  • [ISSN] 1423-002X
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 2S9ZZM9Q9V / Bevacizumab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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19. Lilic V, Lilic G, Filipovic S, Visnjic M, Zivadinovic R: Primary carcinoma of the vagina. J BUON; 2010 Apr-Jun;15(2):241-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary carcinoma of the vagina.
  • In this paper we reviewed the risk factors for primary carcinoma of the vagina (PCV), diagnostic and therapeutic modalities, and principles leading to rational decision-making in the individualized management of vaginal carcinoma patients.
  • Histopathologically, most common are squamous cell carcinoma (80-90%) and adenocarcinoma (4-10%).
  • The leading risk factor for vaginal intraepithelial neoplasia (VAIN) and subsequent squamous cell vaginal carcinoma is long-lasting infection with human papillomavirus (HPV) type 16.
  • In most centres, standard treatment for this cancer is radiotherapy.
  • The supposed advantage of radiotherapy is the preservation of the anatomy and function of the vagina.
  • We believe that there are certain psychologic benefits with the preservation of the vagina, regardless of its function.
  • However, preservation of the vaginal function after treatment of invasive vaginal cancer is a rare phenomenon, both in the literature and from our own experience.
  • [MeSH-major] Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / epidemiology

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  • (PMID = 20658716.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Number-of-references] 45
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20. Langmár Z, Harsányi L, Székely E, Járay B, Csömör S, Kazy Z: [Primary adenocarcinoma of the rectovaginal septum without associated endometriosis]. Orv Hetil; 2008 Nov 23;149(47):2251-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary adenocarcinoma of the rectovaginal septum without associated endometriosis].
  • Primary adenocarcinoma of the rectovaginal septum is a rare clinical entity that arises in most of the cases from endometriosis.
  • The authors report a successfully treated case of primary adenocarcinoma of the rectovaginal septum without associated endometriosis in a 68-year-old woman.
  • Diagnostic and treatment modalities were reviewed by the authors emphasizing that the early diagnosis is difficult and the only curative method is primary surgical therapy.
  • [MeSH-major] Carcinoma, Endometrioid. Genital Neoplasms, Female. Rectal Neoplasms. Vagina
  • [MeSH-minor] Aged. Early Diagnosis. Female. Humans. Ovarian Neoplasms / secondary

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  • (PMID = 19004748.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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21. Li H, Gou HY, Han JS, Li SM, Yang R, Qiao J: [Analysis of the diagnosis and treatment of cervical minimal deviation adenocarcinoma]. Zhonghua Zhong Liu Za Zhi; 2008 Oct;30(10):772-4
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  • [Title] [Analysis of the diagnosis and treatment of cervical minimal deviation adenocarcinoma].
  • OBJECTIVE: To analyze the characteristics of cervical minimal deviation adenocarcinoma (MDA) and the methods of diagnosis and treatment.
  • The main symptoms were increased discharge and irregular vaginal bleeding.
  • Preoperative Pap smears showed adenocarcinoma in 3 cases (27.3%).
  • The diagnosis of MDA was confirmed in 8 cases by cervical punch biopsies (53.3%) and 2 cases by conization.
  • Four cases experienced recurrence in the vagina and pelvis at 2 years after operation.
  • CONCLUSION: Cervical minimal deviation adenocarcinoma is rare, with minimal deviation of cell shape from the normal cervical cells and difficult in diagnosis.
  • A deep biopsy or conization is necessary when punch biopsy is not sufficient for diagnosis.
  • Immunohistochemistry is helpful to make an accurate diagnosis.
  • Surgery is the first choice for cervical minimal deviation adenocarcinoma.
  • [MeSH-major] Adenocarcinoma. Cervix Uteri / pathology. Hysterectomy / methods. Uterine Cervical Neoplasms
  • [MeSH-minor] Actins / metabolism. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoembryonic Antigen / metabolism. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Conization. Epirubicin / administration & dosage. Female. Fluorouracil / administration & dosage. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Papanicolaou Test. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Vaginal Smears


22. Jin B, Pickens A, Shah MB, Turrisi A, Saleh H: Primary large cell neuroendocrine carcinoma of the vagina: cytomorphology of previously unreported case. Diagn Cytopathol; 2010 Dec;38(12):925-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary large cell neuroendocrine carcinoma of the vagina: cytomorphology of previously unreported case.
  • Squamous carcinoma is the most common malignancy of the vagina.
  • Other malignancies include adenocarcinoma, melanoma, lymphoma, and very rarely, neuroendocrine carcinoma/small-cell carcinoma.
  • In this report, we describe a case of LCNEC of the vagina, which is believed to be the first case to date in the English literature.
  • The patient is a 53-year old gravida 3, para 2, African-American woman who had a 4 month history of severe pelvic pain and difficulty voiding and was found to have a firm plate-like mass on the anterior vaginal wall.
  • Thin prep of vaginal swap was interpreted as atypical glandular cells; however, the biopsies showed a large cell neuroendocrine carcinoma which was confirmed by diffuse strong immunoreactivity to AE1/3, CAM5.2, CK7, and CD56 in the tumor cells.
  • Subsequent clinical workup showed that the patient also had numerous metastatic nodules in the bilateral lungs and a vaginal-urethral fistula caused by the tumor.
  • Although the vaginal tumor increased in size even after radiation, her symptoms were under control and she was doing well for a short period of time.
  • The patient is still alive but developed brain metastasis a year later after initial diagnosis.
  • Despite its rarity, large cell neuroendocrine cell carcinoma should be included in the differential diagnosis when cytomorphology shows features suggestive of neuroendocrine differentiation.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Vaginal Neoplasms / pathology

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20222107.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56
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23. van der Aa MA, Helmerhorst TJ, Siesling S, Riemersma S, Coebergh JW: Vaginal and (uncommon) cervical cancers in the Netherlands, 1989-2003. Int J Gynecol Cancer; 2010 May;20(4):638-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vaginal and (uncommon) cervical cancers in the Netherlands, 1989-2003.
  • BACKGROUND: The clinical and prognostic evaluation of cervical and vaginal tumors other than squamous cell and adenocarcinomas is hampered by the low incidence, and clinical and epidemiological studies on these uncommon tumors are scarce.
  • Having close affinity with the pathology laboratories, the Netherlands Cancer Registry offers a great opportunity to study frequency, stage, treatment, and survival of uncommon tumors in the cervix and vagina and separately, the clear cell adenocarcinoma of the vagina and cervix.
  • METHODS: All invasive cervical tumors (n = 10,570) and all in situ and invasive vaginal tumors (n = 778) diagnosed in the Netherlands during 1989-2003 were selected from the Netherlands Cancer Registry.
  • Age, stage at diagnosis, and treatment were described for each histological subgroup to find differences between common and uncommon tumors, including 5-year relative survival rates.
  • RESULTS: Twenty-five patients (3%) with cervical cancer subsequently developed a vaginal tumor (during 1989-2003), and 19 of these patients underwent hysterectomy for their cervical cancer.
  • A significantly worse prognosis was found for patients with small cell neuroendocrine cervical tumors and for patients with vaginal melanomas.
  • Patients with clear cell adenocarcinoma of the vagina and cervix were found across all age categories.
  • CONCLUSIONS: The less common histological types of cervical and vaginal cancers were clearly different from squamous cell carcinomas, especially with respect to age at diagnosis and survival rates.
  • [MeSH-major] Adenocarcinoma / mortality. Carcinoma, Squamous Cell / mortality. Neoplasms, Glandular and Epithelial / mortality. Uterine Cervical Neoplasms / mortality. Vaginal Neoplasms / mortality

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  • (PMID = 20686385.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Romero FR, Fucs M, Castro MG, Garcia CR, Fernandes Rde C, Perez MD: Adenocarcinoma of persistent müllerian duct remnants: case report and differential diagnosis. Urology; 2005 Jul;66(1):194-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of persistent müllerian duct remnants: case report and differential diagnosis.
  • Persistent müllerian duct syndrome is an unusual disorder characterized by cryptorchidism and retention of müllerian derivatives (uterus, fallopian tubes, and upper vagina).
  • We report the case of a 39-year-old man with this syndrome in association with adenocarcinoma from the retained müllerian remnants of probable endocervical origin.
  • To our knowledge, this is the first report of an endocervical adenocarcinoma associated with persistent müllerian duct syndrome.
  • [MeSH-major] Adenocarcinoma / complications. Cryptorchidism / complications. Mullerian Ducts / abnormalities
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 16009404.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Takemoto S, Ushijima K, Nakaso K, Fujiyoshi N, Kamura T: Primary adenocarcinoma of the vagina successfully treated with neoadjuvant chemotherapy consisting of paclitaxel and carboplatin. J Obstet Gynaecol Res; 2009 Jun;35(3):579-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenocarcinoma of the vagina successfully treated with neoadjuvant chemotherapy consisting of paclitaxel and carboplatin.
  • Primary vaginal adenocarcinoma unassociated with antenatal diethylstilbestrol (DES) exposure is extremely rare.
  • A 69-year-old woman presented with vaginal bleeding but no history of antenatal DES exposure.
  • She had a solid tumor in the recto-vaginal space, diagnosed as FIGO stage III vaginal adenocarcinoma.
  • Thereafter, radiotherapy was applied to the pelvis and vagina in order to reinforce the state of remission.
  • [MeSH-major] Adenocarcinoma / drug therapy. Carboplatin / administration & dosage. Neoadjuvant Therapy. Paclitaxel / administration & dosage. Vaginal Neoplasms / drug therapy

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  • (PMID = 19527405.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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26. Laurent S, Barbeaux A, Detroz B, Detry O, Louis E, Belaiche J, Meurisse M: Development of adenocarcinoma in chronic fistula in Crohn's disease. Acta Gastroenterol Belg; 2005 Jan-Mar;68(1):98-100
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  • [Title] Development of adenocarcinoma in chronic fistula in Crohn's disease.
  • Long-standing anorectal fistulas and stricture led to adenocarcinoma and finally fistulisation in the vagina.
  • Diagnosis was made by perineal examination with biopsies under general anaesthesia.
  • Treatment was first posterior pelvectomy with resection of the anterior wall of vagina.
  • [MeSH-major] Adenocarcinoma / pathology. Crohn Disease / pathology. Precancerous Conditions / pathology. Rectal Neoplasms / pathology. Rectovaginal Fistula / pathology

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  • (PMID = 15832595.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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27. Frank SJ, Deavers MT, Jhingran A, Bodurka DC, Eifel PJ: Primary adenocarcinoma of the vagina not associated with diethylstilbestrol (DES) exposure. Gynecol Oncol; 2007 May;105(2):470-4
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  • [Title] Primary adenocarcinoma of the vagina not associated with diethylstilbestrol (DES) exposure.
  • OBJECTIVE: Primary non-diethylstilbestrol (DES)-associated adenocarcinoma of the vagina (NDAV) is a rare entity that has not been well described.
  • Survival rates were calculated and outcomes of patients with NDAV were compared with those of patients with squamous cell carcinoma (SCC) of the vagina treated similarly over the same period.
  • [MeSH-major] Adenocarcinoma / etiology. Adenocarcinoma / pathology. Diethylstilbestrol / adverse effects. Vaginal Neoplasms / etiology. Vaginal Neoplasms / pathology

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  • (PMID = 17292459.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 731DCA35BT / Diethylstilbestrol
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28. Hurrell DP, Jamison J, Dobbs SP, McCluggage WG: Cervical adenocarcinoma in situ recurring as vaginal adenocarcinoma 16 years after hysterectomy. Int J Gynecol Pathol; 2009 May;28(3):296-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cervical adenocarcinoma in situ recurring as vaginal adenocarcinoma 16 years after hysterectomy.
  • We report a case in which a vaginal adenocarcinoma was discovered in a 67-year-old woman 16 years after hysterectomy for cervical adenocarcinoma in situ.
  • Both the vaginal and cervical lesions exhibited morphologic and immunohistochemical (CDX2-positive) features of intestinal differentiation.
  • Linear array human papillomavirus genotyping demonstrated the vaginal adenocarcinoma to contain human papillomavirus 45.
  • We believe the vaginal adenocarcinoma to be related to the cervical adenocarcinoma in situ and to represent recurrence of this.
  • [MeSH-major] Adenocarcinoma / pathology. Cervical Intraepithelial Neoplasia / pathology. Neoplasm Recurrence, Local / pathology. Uterine Cervical Neoplasms / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 19620950.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Dubé V, Lickrish GM, MacNeill KN, Colgan TJ: Villoglandular adenocarcinoma in situ of intestinal type of the hymen: de novo origin from squamous mucosa? J Low Genit Tract Dis; 2006 Jul;10(3):156-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Villoglandular adenocarcinoma in situ of intestinal type of the hymen: de novo origin from squamous mucosa?
  • Villoglandular adenocarcinoma of intestinal type is a very uncommon neoplasm of unknown origin with only few cases described on the vulva and in the vagina.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma in Situ / diagnosis. Hymen / pathology. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Epithelium / pathology. Female. Humans. Middle Aged. Vaginal Discharge / etiology

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  • (PMID = 16829755.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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30. Chu M, Crist H, Zaino RJ: Adenocarcinoma arising in a rectovaginal fistula in Crohn disease. Int J Gynecol Pathol; 2010 Sep;29(5):497-500
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma arising in a rectovaginal fistula in Crohn disease.
  • Adenocarcinomas occurring in the vagina are rare.
  • Although most adenocarcinomas in the vagina arise from other sites in the female genital tract, a significant minority reflects metastasis from a colorectal site.
  • We report a very unusual occurrence of an adenocarcinoma that presented as a mass in the vagina protruding through the introitus.
  • Neither the initial clinical examination nor the pathologic examination suggested the correct diagnosis.
  • We report this case to remind the gynecologists of the potential complications of Crohn disease, and to highlight for the pathologists the difficulty that is often encountered in the correct identification of the source of carcinomas that are found in the vagina.
  • [MeSH-major] Adenocarcinoma / secondary. Colorectal Neoplasms / pathology. Crohn Disease / complications. Rectovaginal Fistula / complications. Vaginal Neoplasms / secondary

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  • (PMID = 20736780.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Farah-Klibi F, Kourda-Boujemaa J, Bouaskar I, Dziri C, Rachida Z, Jilani-Baltagi SB: Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature. Pathologica; 2009 Dec;101(6):255-60

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  • [Title] Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature.
  • We present a unique case of primary cystadenocarcinoma of the appendix occurring concurrently with adenocarcinoma of the colon, and overview the clinical and therapeutic difficulties posed by this rare entity.
  • Degenerated adenomatous polyp of the ascending colon and mucinous adenocarcinoma of the sigmoid colon invading the parietal peritoneum of the uterine and vagina was diagnosed.
  • CONCLUSIONS: Preoperative diagnosis of an underlying malignancy in a mucocele is important for patient management, but is difficult to reach by imaging studies alone.
  • Synchronous colon cancer may occur in patients with appendiceal mucoceles.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Colonic Neoplasms / pathology. Cystadenocarcinoma / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 20387715.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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32. Kalir T, Simsir A, Demopoulos HB, Demopoulos RI: Obstacles to the early detection of endocervical adenocarcinoma. Int J Gynecol Pathol; 2005 Oct;24(4):399-403
International Agency for Research on Cancer - Screening Group. diagnostics - A practical manual on visual screening for cervical neoplasia .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Obstacles to the early detection of endocervical adenocarcinoma.
  • Among the 23 patients with invasive disease that spared the TZ, 6 (26%) had a documented history of negative Pap smears at New York University within 3 years of diagnosis.
  • Four extended downward into the exocervix through the stroma, sparing the surface mucosa; one reached the upper vagina.
  • [MeSH-major] Adenocarcinoma / diagnosis. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Cell Transformation, Neoplastic / pathology. False Negative Reactions. Female. Humans. Hysterectomy. Neoplasm Invasiveness. Neoplasm Staging. Papanicolaou Test. Time Factors. Vaginal Smears

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  • (PMID = 16175089.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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33. Wani Y, Notohara K, Tsukayama C: Mesonephric adenocarcinoma of the uterine corpus: a case report and review of the literature. Int J Gynecol Pathol; 2008 Jul;27(3):346-52
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesonephric adenocarcinoma of the uterine corpus: a case report and review of the literature.
  • Mesonephric adenocarcinoma (MA) is a rare tumor of the female genital tract, mainly in the cervix and vagina, which is usually associated with mesonephric remnants or mesonephric hyperplasia.
  • In addition, the ductal pattern simulating endometrioid adenocarcinoma was also noted.
  • Other elements consisted of a retiform pattern, serous adenocarcinoma-like papillary budding, and glomeruloid morphology.
  • We review the previously published cases of MA and discuss the principal differential diagnosis of MA in the uterine corpus.
  • [MeSH-major] Adenocarcinoma / pathology. Uterine Neoplasms / pathology

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  • (PMID = 18580312.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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34. Takeuchi M, Matsuzaki K, Nishitani H: Clear cell adenocarcinoma of the female urethra: magnetic resonance imaging. J Comput Assist Tomogr; 2009 Jan-Feb;33(1):142-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell adenocarcinoma of the female urethra: magnetic resonance imaging.
  • Clear cell adenocarcinoma of the female urethra is a rare malignant tumor arising from urethral diverticulum or paraurethral ducts and glands, and extends to the submucosa surrounding the urethra.
  • In the advanced stage, the tumor may involve adjacent organs such as the vagina, and may mimic gynecologic malignancy.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Magnetic Resonance Imaging / methods. Urethral Neoplasms / diagnosis

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  • (PMID = 19188802.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Bedaiwy MA, Hussein MR, Biscotti C, Falcone T: Pelvic endometriosis is rarely associated with ovarian borderline tumours, cytologic and architectural atypia: a clinicopathologic study. Pathol Oncol Res; 2009 Mar;15(1):81-8
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  • Endometriotic foci, especially ovarian ones, with epithelial cytologic atypia may be precursors of cancer.
  • The endometriotic lesions were associated with uterine leiomyomas (two patients) and adenocarcinoma of the vagina (one patient).
  • In two cases, these features were sufficient for diagnosis of borderline Mullerian seromucinous tumours.
  • One patient had recurred with metastatic adenocarcinoma of the vault.

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  • (PMID = 18575828.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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36. Lin LM, Sciubba DM, Gallia GL, Sosnowski J, Weingart JD: Diethylstilbestrol (DES)-induced clear cell adenocarcinoma of the vagina metastasizing to the brain. Gynecol Oncol; 2007 Apr;105(1):273-6
Hazardous Substances Data Bank. DIETHYLSTILBESTROL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diethylstilbestrol (DES)-induced clear cell adenocarcinoma of the vagina metastasizing to the brain.
  • BACKGROUND: Primary vaginal clear cell adenocarcinoma (CCA) is a rare gynecological malignancy occurring predominantly in young females with a history of diethylstilbestrol exposure in utero.
  • Vaginal CCA commonly metastasizes to the lungs and the supraclavicular lymph nodes; however we present a rare case of diethylstilbestrol-induced vaginal CCA with cerebral metastases.
  • CASE DESCRIPTION: A 43-year-old woman with prenatal diethylstilbestrol exposure and history of vaginal CCA treatment 8 years prior to current presentation noted new onset headache and dizziness.
  • CONCLUSIONS: This case report highlights the necessity of close extended follow-up in patients with a history of vaginal CCA and demonstrates the potential for spread of primary vaginal CCA to the brain.
  • [MeSH-major] Adenocarcinoma, Clear Cell / chemically induced. Brain Neoplasms / secondary. Diethylstilbestrol / adverse effects. Prenatal Exposure Delayed Effects. Vaginal Neoplasms / chemically induced

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  • (PMID = 17292458.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 731DCA35BT / Diethylstilbestrol
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37. Dasanu CA, Herzog TJ: Clear cell adenocarcinoma of the ovary associated with in utero diethylstilbestrol exposure: case report and clinical overview. Medscape J Med; 2009;11(1):6
Hazardous Substances Data Bank. DIETHYLSTILBESTROL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell adenocarcinoma of the ovary associated with in utero diethylstilbestrol exposure: case report and clinical overview.
  • BACKGROUND: Clear cell adenocarcinoma of the vagina and cervix were previously shown to be tumors occurring in female offspring exposed prenatally to diethylstilbestrol.
  • This report describes the first clinical case of clear cell adenocarcinoma of the ovary linked to early diethylstilbestrol exposure in utero.
  • She underwent surgery and staging that revealed clear cell adenocarcinoma confined to the left ovary.
  • CONCLUSION: Our case is consistent with clear cell adenocarcinoma, probably related to diethylstilbestrol exposure in utero.
  • [MeSH-major] Adenocarcinoma, Clear Cell / chemically induced. Diethylstilbestrol / adverse effects. Ovarian Neoplasms / chemically induced. Prenatal Exposure Delayed Effects / chemically induced

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  • (PMID = 19295927.001).
  • [ISSN] 1934-1997
  • [Journal-full-title] Medscape journal of medicine
  • [ISO-abbreviation] Medscape J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 731DCA35BT / Diethylstilbestrol
  • [Other-IDs] NLM/ PMC2654676
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38. Park KJ, Bramlage MP, Ellenson LH, Pirog EC: Immunoprofile of adenocarcinomas of the endometrium, endocervix, and ovary with mucinous differentiation. Appl Immunohistochem Mol Morphol; 2009 Jan;17(1):8-11
International Agency for Research on Cancer - Screening Group. diagnostics - A practical manual on visual screening for cervical neoplasia .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A total of 64 cases were collected, including adenocarcinomas of the ovary (n=13), endocervix (n=16), endometrium (n=34), and vagina (n=1), all of which showed predominant mucinous differentiation.
  • Intestinal mucinous differentiation was present in 11 of the cases (6 endocervical, 4 ovarian, and 1 vaginal adenocarcinoma).
  • [MeSH-major] Adenocarcinoma / diagnosis. Ovarian Neoplasms / diagnosis. Uterine Cervical Neoplasms / diagnosis

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  • (PMID = 18776815.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 Transcription Factor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Keratin-7; 0 / Neoplasm Proteins
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39. Parikh JH, Barton DP, Ind TE, Sohaib SA: MR imaging features of vaginal malignancies. Radiographics; 2008 Jan-Feb;28(1):49-63; quiz 322
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MR imaging features of vaginal malignancies.
  • Primary vaginal malignancies are rare, accounting for only 1%-2% of all gynecologic malignancies.
  • Squamous cell carcinoma makes up about 85% of primary vaginal malignancies.
  • This tumor characteristically arises from the posterior wall of the upper third of the vagina.
  • The tumors that account for the remaining 15% of primary vaginal malignancies are adenocarcinoma, melanoma, and sarcomas.
  • Secondary malignancy of the vagina is far more frequent than primary vaginal malignancy.
  • Most vaginal metastases occur by means of direct local spread from the cervix, uterus, or rectum.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Image Enhancement / methods. Magnetic Resonance Imaging / methods. Vagina / pathology. Vaginal Neoplasms / diagnosis

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  • (PMID = 18203930.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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40. Sameshima H, Nagai K, Ikenoue T: Single vaginal ectopic ureter of fetal metanephric duct origin, ipsilateral kidney agenesis, and ipsilateral rudimentary uterine horn of the bicornuate uterus. Gynecol Oncol; 2005 Apr;97(1):276-8
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

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  • [Title] Single vaginal ectopic ureter of fetal metanephric duct origin, ipsilateral kidney agenesis, and ipsilateral rudimentary uterine horn of the bicornuate uterus.
  • CASE: Two Japanese women had a single ectopic ureter opening in the central wall of the vagina, ipsilateral kidney agenesis, and ipsilateral rudimentary uterine horn of the bicornuate uterus.
  • One had squamous cell carcinoma of the uterine cervix, and the other had adenocarcinoma of the vagina arising from the ectopic ureter meatus, which was histologically confirmed as fetal metanephric duct remnant.
  • One had vesico-vaginal fistula postoperatively, resulting from separating the ureter-like duct from the bladder.
  • Clinically, the ectopic vaginal ureter is important as a possible background of vaginal adenocarcinoma, and information on the ureter-like duct course is required during surgery.
  • [MeSH-major] Adenocarcinoma / etiology. Carcinoma, Squamous Cell / etiology. Kidney / abnormalities. Ureter / abnormalities. Uterine Cervical Neoplasms / etiology. Uterus / abnormalities. Vaginal Neoplasms / etiology

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  • (PMID = 15790476.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Shivaprakash HN, Jayashree K, Girish M: Villous adenoma: a rare tumor of vaginal vault. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):265-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Villous adenoma: a rare tumor of vaginal vault.
  • Villous adenomas are extremely rare tumors in the vagina and are indistinguishable from their colonic counterparts.
  • The significance of this lesion lies in the fact that it has to be distinguished from metastatic adenocarcinoma from other sites.
  • We present a case of villous adenoma of vaginal vault, a rare site of presentation in a 30-year-old female.
  • [MeSH-major] Adenoma, Villous / pathology. Vaginal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 18603704.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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42. Zorrón R, Soldan M, Filgueiras M, Maggioni LC, Pombo L, Oliveira AL: NOTES: transvaginal for cancer diagnostic staging: preliminary clinical application. Surg Innov; 2008 Sep;15(3):161-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] NOTES: transvaginal for cancer diagnostic staging: preliminary clinical application.
  • Laparoscopy is now a reliable method for staging gastrointestinal cancer, orienting the therapy, and avoiding unnecessary laparotomy.
  • The first case of clinical diagnostic application of transvaginal NOTES for diagnostic cancer staging is presented.
  • On February 28, 2007, a patient with elective surgical indication for diagnostic cancer staging was submitted to transvaginal NOTES procedure, and intra- and postoperative parameters were documented.
  • In a 50-year-old female patient presenting with ascitis, diffuse abdominal pain, and weight loss for 2 months, diagnosis of peritoneal carcinomatosis was suspected, which was also found when a CT scan was performed.
  • Transvaginal NOTES was used for diagnostic staging of the patient, using a colonoscope introduced into the abdomen through a small incision in the vagina.
  • Operative time was 105 min, vaginal access and closure was obtained in 15 min.
  • Abdominal inventory was reliable, and all 16 biopsies taken were positive for ovarian adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Endoscopy / methods. Endoscopy / trends. Ovarian Neoplasms / diagnosis

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  • (PMID = 18614547.001).
  • [ISSN] 1553-3506
  • [Journal-full-title] Surgical innovation
  • [ISO-abbreviation] Surg Innov
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Chuang LT, Lerner DL, Liu CS, Nezhat FR: Fertility-sparing robotic-assisted radical trachelectomy and bilateral pelvic lymphadenectomy in early-stage cervical cancer. J Minim Invasive Gynecol; 2008 Nov-Dec;15(6):767-70
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fertility-sparing robotic-assisted radical trachelectomy and bilateral pelvic lymphadenectomy in early-stage cervical cancer.
  • A combined pelvic lymphadenectomy with radical vaginal trachelectomy is an alternative to radical hysterectomy in the treatment of young women with cervical cancer desiring fertility preservation.
  • This technique requires advanced vaginal surgery skills not commonly acquired.
  • A 30-year-old woman, gravida 1, para 1, desiring fertility preservation was given the diagnosis of invasive adenocarcinoma on cervical cone excision.
  • We hope robotic-assisted radical trachelectomy will become an option for select women with early-stage cervical cancer who desire fertility preservation.
  • [MeSH-major] Adenocarcinoma / surgery. Fertility / physiology. Lymph Node Excision / methods. Robotics. Uterine Cervical Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Surgical Instruments. Vagina / pathology

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  • (PMID = 18971147.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Mahdavi A, Shamshirsaz AA, Peiretti M, Zakashansky K, Idrees MT, Nezhat F: Laparoscopic management of vaginal clear cell adenocarcinoma arising in pelvic endometriosis: case report and literature review. J Minim Invasive Gynecol; 2006 May-Jun;13(3):237-41
MedlinePlus Health Information. consumer health - Vaginal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic management of vaginal clear cell adenocarcinoma arising in pelvic endometriosis: case report and literature review.
  • Vaginal clear cell adenocarcinoma arising from pelvic endometriosis has not been reported in the literature.
  • We report a case of a 50-year-old woman with stage I clear cell adenocarcinoma of the vagina who was found to have endometriosis adjacent to the vaginal tumor.
  • She was treated with neoadjuvant chemoradiation, laparoscopically assisted radical vaginal hysterectomy, radical upper vaginectomy, and pelvic lymphadenectomy followed by combination chemotherapy.
  • [MeSH-major] Adenocarcinoma, Clear Cell / surgery. Endometriosis / complications. Endometriosis / surgery. Vaginal Neoplasms / surgery

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  • (PMID = 16698533.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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45. López C, Balogun M, Ganesan R, Olliff JF: MRI of vaginal conditions. Clin Radiol; 2005 Jun;60(6):648-62
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  • [Title] MRI of vaginal conditions.
  • Magnetic resonance imaging (MRI) has become an important part of the assessment of suspected vaginal pathology.
  • This pictorial review demonstrates the MRI features and some of the histopathological findings of a variety of vaginal conditions.
  • These may be congenital (total vaginal agenesis, partial vaginal agenesis, longitudinal vaginal septum, transverse vaginal septum), benign (Bartholin's cyst, diffuse vaginal inflammation, invasive endometriosis, ureterovaginal fistula, post-surgical appearances with the formation of a neovagina and adhesions) or malignant, usually due to extension or recurrence from another pelvic malignancy.
  • In this paper, examples of the above are described and illustrated together with examples of the much rarer primary vaginal malignancies.
  • [MeSH-major] Magnetic Resonance Imaging. Vagina / abnormalities. Vagina / pathology. Vaginal Diseases / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Female. Humans. Middle Aged. Sensitivity and Specificity. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / surgery

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  • (PMID = 16038691.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 27
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46. Kobayashi H, Sumimoto K, Kitanaka T, Yamada Y, Sado T, Sakata M, Yoshida S, Kawaguchi R, Kanayama S, Shigetomi H, Haruta S, Tsuji Y, Ueda S, Terao T: Ovarian endometrioma--risks factors of ovarian cancer development. Eur J Obstet Gynecol Reprod Biol; 2008 Jun;138(2):187-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian endometrioma--risks factors of ovarian cancer development.
  • OBJECTIVE: Our prospective studies in Japan have found an increased ovarian cancer incidence in women with ovarian endometrioma (standardized incidence ratio, 8.95; 95% confidence intervals, 4.12-5.3).
  • The risk increased with increasing age at ovarian endometrioma diagnosis.
  • The goal of this study was to define the risk factor(s) of ovarian cancer development in a Japanese population with ovarian endometrioma.
  • We also analyzed whether the predisposition toward ovarian cancer is limited to endometrioid and clear cell carcinoma.
  • STUDY DESIGN: A total of 6398 participants at 212 participating hospitals in Shizuoka, Japan, were enrolled in the Shizuoka Cohort Study on Endometriosis and Ovarian Cancer (SCSEOC) Trial, which had prospective and retrospective components.
  • The risks of development of ovarian cancer were assessed in 6398 women with ultrasonographically diagnosed ovarian endometriomas.
  • Cox proportional-hazards regression function was used to estimate impact in terms of risk factors and possible development of ovarian cancer.
  • RESULTS: The prospective study demonstrated that 46 (0.72%) of 6398 women developed histologically proven ovarian cancer and were operated upon during follow-up.
  • Clear cell carcinoma (39%) and endometrioid adenocarcinoma (35%) were commonly observed among women with ovarian cancer.
  • By multivariate analysis, tumor size > or =9 cm in diameter and postmenopausal women were independent predictive factors of patients with development of ovarian cancer.
  • Advancing age and the size of endometriomas were independent predictors of development of ovarian cancer among women with ovarian endometrioma.
  • [MeSH-minor] Adult. Female. Humans. Menopause. Middle Aged. Proportional Hazards Models. Prospective Studies. Risk Factors. Vagina / ultrasonography

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  • (PMID = 18162283.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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47. Lotan TL, Tefs K, Schuster V, Miller J, Manaligod J, Filstead A, Yamada SD, Krausz T: Inherited plasminogen deficiency presenting as ligneous vaginitis: a case report with molecular correlation and review of the literature. Hum Pathol; 2007 Oct;38(10):1569-75
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  • Microscopically, the vagina, cervix, endometrium, ovaries, and parametrial tissues showed innumerable deposits of paucicellular hyaline material with adjacent inflammation.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Adult. Diagnosis, Differential. Female. Humans. Vaginal Neoplasms / pathology

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  • (PMID = 17889676.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9001-91-6 / Plasminogen
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48. Hollowell ML, Goulart RA, Gang DL, Otis CN, Prior J, Sachs BF, Pantanowitz L: Cytologic features of müllerian papilloma of the cervix: mimic of malignancy. Diagn Cytopathol; 2007 Sep;35(9):607-11
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  • Müllerian papilloma is a rare benign tumor of the cervix and/or vagina that occurs predominantly in young children.
  • We report for the first time, to our knowledge, the cytologic findings of a benign müllerian papilloma from the vaginal fluid specimen of a 15-mo-old girl using touch prep, ThinPrep, and cell block preparations.
  • The clinical findings and cytomorphology of a benign müllerian papilloma can mimic those of malignant lesions of the female lower genital tract such as sarcoma botryoides and adenocarcinoma.
  • An awareness of this entity and its potential to mimic these more aggressive neoplasms is essential for accurate diagnosis and to avoid over-treatment.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Diagnosis, Differential. Female. Humans. Infant. Rhabdomyosarcoma, Embryonal / diagnosis. Rhabdomyosarcoma, Embryonal / pathology


49. Sinha B, Stehman F, Schilder J, Clark L, Cardenes H: Indiana University experience in the management of vaginal cancer. Int J Gynecol Cancer; 2009 May;19(4):686-93
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  • [Title] Indiana University experience in the management of vaginal cancer.
  • PURPOSE: To review our institutional experience in the treatment of primary vaginal cancer and identify predictors for outcome, in particular, recurrence rate.
  • MATERIALS AND METHODS: We retrospectively reviewed the charts of 45 patients identified as having primary squamous cell cancer and adenocarcinoma of the vagina and recorded information regarding both patient and tumor characteristics and treatment modalities.
  • CONCLUSIONS: Early-stage vaginal cancer can be successfully managed with radiation therapy with excellent rates of local control and survival.
  • [MeSH-major] Adenocarcinoma / therapy. Carcinoma, Squamous Cell / therapy. Vaginal Neoplasms / therapy

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  • (PMID = 19509572.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Milathianakis CN, Karamanolakis DK, Massoud WA, Roumier X, Bogdanos IM, Perrin P: [Vaginal metastases from renal cell carcinoma]. Prog Urol; 2005 Apr;15(2):319-21
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  • [Title] [Vaginal metastases from renal cell carcinoma].
  • Renal cell carcinoma rarely metastasizes to the vagina, as only 80 cases have been reported in the literature.
  • Due to the anatomical features of the venous drainage of the left kidney, most vaginal metastases are derived from left renal tumours.
  • Renal imaging looking for a renal tumour must be performed in the presence of a vaginal adenocarcinoma or undifferentiated carcinoma.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Vaginal Neoplasms / secondary

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  • (PMID = 15999617.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 6
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51. Minoguchi M, Yanagawa N, Ishikawa C, Sasajima J, Goto M, Okamoto M, Saito Y, Murakami M, Orii Y, Yaosaka T: [Pancreatic metastasis of malignant melanoma diagnosed by EUS-guided fine needle aspiration (EUS-FNA)]. Nihon Shokakibyo Gakkai Zasshi; 2007 Jul;104(7):1082-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Her past medical history included a radical hysterectomy 2 years previously for malignant melanoma of the vagina.
  • Imaging studies including US, CT, and MRI have limited value to distinguish the tumors from primary ductal adenocarcinoma.
  • EUS-FNA can provide tissue diagnosis from pancreatic masses, specifically when other modalities have failed.
  • [MeSH-major] Melanoma / diagnosis. Melanoma / secondary. Pancreas / pathology. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / secondary. Vaginal Neoplasms / pathology

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  • (PMID = 17611386.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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52. Goker BO, Bese T, Ilvan S, Yilmaz E, Demirkiran F: A case with multiple gynecological malignancies. Int J Gynecol Cancer; 2005 Mar-Apr;15(2):372-6
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  • Fourteen months after the diagnosis of the lymphoma, an endometrial adenocarcinoma was detected as a secondary malignant tumor.
  • Approximately 7 years after the diagnosis of endometrial cancer, vaginal invasive squamous cell carcinoma was diagnosed as the third primary malignancy, and a second-line palliative radiotherapy was applied.
  • Seven months after the last radiotherapy, postradiational sarcoma in the vagina was diagnosed.
  • [MeSH-major] Adenocarcinoma / pathology. Endometrial Neoplasms / pathology. Lymphoma, Non-Hodgkin / drug therapy. Neoplasms, Multiple Primary / pathology. Sarcoma / pathology. Uterine Cervical Neoplasms / drug therapy. Vaginal Neoplasms / pathology

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  • (PMID = 15823128.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Koo HR, Oh YT, Kim YT, Kim SW, Kang JH, Kim KW: Intrauterine device found in an ovarian carcinoma. J Comput Assist Tomogr; 2008 Jan-Feb;32(1):69-71
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  • However, there is no report of IUD located within an ovarian carcinoma to our knowledge, and our report is the first case of an IUD found in the center of an ovarian cancer.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Foreign-Body Migration / diagnosis. Intrauterine Devices / adverse effects. Ovarian Neoplasms / diagnosis. Uterine Perforation / diagnosis. Uterine Perforation / etiology
  • [MeSH-minor] Abdominal Pain / etiology. Aged. Female. Humans. Magnetic Resonance Imaging. Uterus / pathology. Uterus / ultrasonography. Vagina / pathology. Vagina / radiography. Vagina / ultrasonography

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  • (PMID = 18303291.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Ajit D, Gavas S, Jagtap S, Chinoy RF: Cytodiagnostic problems in cervicovaginal smears from symptomatic breast cancer patients on tamoxifen therapy. Acta Cytol; 2009 Jul-Aug;53(4):383-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytodiagnostic problems in cervicovaginal smears from symptomatic breast cancer patients on tamoxifen therapy.
  • OBJECTIVE: To evaluate the effect of tamoxifen on cervicovaginal epithelium, identify tamoxifen-related changes that mimic cancer and detennine the morphologic features differentiating the 2 changes.
  • STUDY DESIGN: Cervicovaginal smears from 153 conventionally treated primary breast cancer patients presenting with gynecologic symptoms were studied.
  • Of the 6 cases reported as adenocarcinoma, 3 were histologically confirmed, and the others were false positives.
  • Tamoxifen-associated cellular changes can mimic morphologic features of cancer.
  • [MeSH-major] Cervix Uteri / pathology. Tamoxifen / adverse effects. Uterine Cervical Neoplasms / pathology. Vagina / pathology. Vaginal Neoplasms / pathology. Vaginal Smears
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Antineoplastic Agents, Hormonal / adverse effects. Breast Neoplasms / drug therapy. Diagnosis, Differential. False Positive Reactions. Female. Humans. Middle Aged


55. Stringer EM, De Voe RS, Valea F, Toma S, Mulvaney G, Pruitt A, Troan B, Loomis MR: Medical and surgical management of reproductive neoplasia in two western lowland gorillas (Gorilla gorilla gorilla). J Med Primatol; 2010 Oct;39(5):328-35
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  • Biopsy results indicated uterine adenocarcinoma.
  • The second gorilla was diagnosed with squamous cell carcinoma of the vagina, cervix, and uterus after presenting for intermittent vaginal bleeding of 1-month duration.
  • CONCLUSIONS: The following report describes the diagnosis and management of the two cases.
  • [MeSH-major] Adenocarcinoma / veterinary. Ape Diseases / diagnosis. Carcinoma, Squamous Cell / veterinary. Gorilla gorilla. Uterine Neoplasms / veterinary. Vaginal Neoplasms / veterinary

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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 20412375.001).
  • [ISSN] 1600-0684
  • [Journal-full-title] Journal of medical primatology
  • [ISO-abbreviation] J. Med. Primatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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56. Coughlan C, McAuliffe F, Bermingham N, Gleeson N: Vaginal cytology following primary hysterectomy for cervical cancer: is it useful? Ir J Med Sci; 2006 Jan-Mar;175(1):45-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vaginal cytology following primary hysterectomy for cervical cancer: is it useful?
  • BACKGROUND: Vaginal intraepithelial neoplasia (VAIN) is usually detected in patients with synchronous or antecedent cervical or vulval intraepithelial or invasive cancer.
  • AIMS: To determine the incidence and severity and analyse the management of vaginal dysplasia in patients undergoing primary hysterectomy for cervical cancer.
  • RESULTS: In follow-up six patients were found to have dyskaryosis in a second vaginal smear.
  • One patient with recurrent squamous cancer received salvage radiotherapy and one with recurrent adenocarcinoma received high dose progestogens and topical 5-fluorouracil.
  • [MeSH-major] Hysterectomy. Uterine Cervical Neoplasms / diagnosis. Vagina / cytology. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Middle Aged. Retrospective Studies. Vaginal Smears / utilization


57. Ozmen O, Haligur M, Kocamuftuoglu M: Clinocopathologic and immunohistochemical findings of multiple genital leiomyomas and mammary adenocarcinomas in a bitch. Reprod Domest Anim; 2008 Jun;43(3):377-81
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  • A 13-year-old female Pointer dog was presented for evaluation of mammary tumours and bloody vaginal discharge at the Veterinary Teaching Hospital of Mehmet Akif Ersoy University, Faculty of Veterinary Medicine.
  • On the history, owner complained of mammary tumours and bloody vaginal discharge.
  • Vaginal cytology revealed numerous pleomorphic and anaplastic cells.
  • Also multiple masses in the cervix and vagina were found.
  • At the necropsy numerous masses were seen at the vagina and cervix and one big mass seen at the left cornu uteri.
  • Histopathological diagnosis was leiomyoma.
  • Histopathologically, mammary tumours were diagnosed as complex type tubulopapillary adenocarcinoma.
  • The objectives of this study were to measure the proliferation indices in canine complex type mammary adenocarcinoma and genital leiomyomas using immunohistochemical detection of Ki-67 and proliferating cell nuclear antigen to determine the relationship of these antigens to clinical and pathologic variables; and to examine the immunoreactivity of these tumours with different markers.
  • [MeSH-major] Adenocarcinoma / veterinary. Dog Diseases / pathology. Leiomyomatosis / veterinary. Mammary Neoplasms, Animal / pathology

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  • (PMID = 18226017.001).
  • [ISSN] 1439-0531
  • [Journal-full-title] Reproduction in domestic animals = Zuchthygiene
  • [ISO-abbreviation] Reprod. Domest. Anim.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen
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58. Sauder K, Wilbur DC, Duska L, Tambouret RH: An approach to post-radical trachelectomy vaginal-isthmus cytology. Diagn Cytopathol; 2009 Jun;37(6):437-42
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An approach to post-radical trachelectomy vaginal-isthmus cytology.
  • Radical trachelectomy (RT) is the surgical amputation of the uterine cervix with paracervical lymphadenectomy, performed in reproductive age women to treat invasive squamous-cell carcinoma or endocervical adenocarcinoma while preserving the uterine corpus for potential child bearing.
  • Post-RT patient monitoring includes isthmic-vaginal cytology.
  • Fifty-four post-RT vaginal-isthmic cytology specimens were reviewed from nine patients, seven with adenocarcinoma, and two with squamous-cell carcinoma.
  • In particular, a primary diagnosis of adenocarcinoma makes differentiating benign reactive glandular cells from recurrence a critical issue.
  • [MeSH-major] Cervix Uteri / surgery. Cytological Techniques / methods. Vagina / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19217064.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Anjarwalla S, Rollason TP, Rooney N, Hirschowitz L: Atypical mucinous metaplasia and intraepithelial neoplasia of the female genital tract--a case report and review of the literature. Int J Gynecol Cancer; 2007 Sep-Oct;17(5):1147-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The metaplastic epithelium extended from the vagina to the serosal surface of the pelvic organs.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Genital Neoplasms, Female / diagnosis
  • [MeSH-minor] Female. Humans. Metaplasia / diagnosis. Metaplasia / pathology

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  • (PMID = 17433059.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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60. Schulte-Baukloh H, Knösel T, Coumbos A, Miller K, Knispel HH: [A look beyond urology: vaginal cancer]. Urologe A; 2006 Dec;45(12):1540-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A look beyond urology: vaginal cancer].
  • Primary carcinomas of the vagina are very rare.
  • Nevertheless, they need to be included in differential diagnoses when carrying out a urological examination of the pelvic floor and the vagina in patients with micturition problems, also in younger patients: we report a case of a 35-year-old woman with a primary carcinoma of the vagina and present a review of the literature.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Urination Disorders / diagnosis. Urination Disorders / prevention & control. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / therapy

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  • [Cites] Gynecol Oncol. 2002 Feb;84(2):263-70 [11812085.001]
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  • (PMID = 16902789.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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61. Hayashi M, Tsuchiya H, Yamamoto N, Karita M, Shirai T, Nishida H, Takeuchi A, Tomita K: Caffeine-potentiated chemotherapy for metastatic carcinoma and lymphoma of bone and soft tissue. Anticancer Res; 2005 May-Jun;25(3c):2399-405
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  • RESULTS: Primary tumors were diagnosed as breast cancer, adenocarcinoma of the lung, clear cell adenocarcinoma of the vagina, diffuse large B-cell lymphoma and gastric cancer.
  • [MeSH-minor] Aged. Breast Neoplasms / drug therapy. Breast Neoplasms / pathology. Drug Synergism. Female. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / pathology. Male. Middle Aged. Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology. Vaginal Neoplasms / drug therapy. Vaginal Neoplasms / pathology

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  • (PMID = 16080466.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 3G6A5W338E / Caffeine
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62. Uehara T, Onda T, Sasajima Y, Sawada M, Kasamatsu T: A case of vaginal clear cell adenocarcinoma complicated with congenital anomalies of the genitourinary tract and metanephric remnant without prenatal diethylstilbestrol exposure. J Obstet Gynaecol Res; 2010 Jun;36(3):681-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of vaginal clear cell adenocarcinoma complicated with congenital anomalies of the genitourinary tract and metanephric remnant without prenatal diethylstilbestrol exposure.
  • Vaginal clear cell adenocarcinoma (CCA) is well known to be associated with prenatal diethylstilbestrol exposure.
  • We present a vaginal CCA with congenital anomalies of the genitourinary tract without prenatal diethylstilbestrol exposure.
  • The examination revealed CCA at the anterior vagina and congenital anomalies.
  • Macroscopically, bicornuate uterus, vaginal septum and left ureteral agenesis were found.
  • Microscopically, vaginal CCA coexisted with adenosis and both metanephric and mesonephric remnants.
  • The vaginal CCA was supposed to derive from coexisting adenosis.
  • Relations between congenital anomalies of the genitourinary tract and vaginal adenocarcinoma were suspected, resultantly.
  • [MeSH-major] Adenocarcinoma, Clear Cell / complications. Adenocarcinoma, Clear Cell / pathology. Urogenital Abnormalities / complications. Vaginal Neoplasms / complications. Vaginal Neoplasms / pathology

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  • (PMID = 20598057.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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63. Novoa Vargas A, Grados García C, Bustillos de Cima R, Malagón Millán B: [Vagina cancer in a young woman exposed to diethylstilbestrol: case report and literature review]. Ginecol Obstet Mex; 2005 Dec;73(12):666-73
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  • [Title] [Vagina cancer in a young woman exposed to diethylstilbestrol: case report and literature review].
  • [Transliterated title] Cáncer de vagina en una mujer joven expuesta a dietilestilbestrol: caso clínico y revisión de la bibliografía.
  • We analyzed a 20 year-old patient case exposed in utero to diethylstilbestrol, as probably predisposed factor in vaginal cancer.
  • The histopathological report of the incisional biopsy was clear cell vaginal adenocarcinoma, stage III, widespread to the pelvic wall, with metastasis to regional lymph nodes, and lack of distant metastasis.
  • We decided surgical management: protocolized laparotomy, peritoneal washing, retroperitoneal node biopsies and a radical hysterectomy, Piver III, with two thirds parts of vagina.
  • [MeSH-major] Adenocarcinoma, Clear Cell / chemically induced. Diethylstilbestrol / adverse effects. Prenatal Exposure Delayed Effects. Vaginal Neoplasms / chemically induced
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Female. Follow-Up Studies. Humans. Hysterectomy. Lymphatic Metastasis. Pregnancy. Prognosis. Radiography, Abdominal. Time Factors. Tomography, X-Ray Computed. Vagina / pathology

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  • (PMID = 16583845.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 731DCA35BT / Diethylstilbestrol
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64. Myriokefalitaki E, Iavazzo C, Vorgias G, Akrivos T: A two eterochronous primary gynaecological malignancies of different origin. Bratisl Lek Listy; 2009;110(11):726-8
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  • CASE: A 65-year-old para-2, white obese female, presented in our department 4 years ago, due to a single event of vaginal spotting.
  • Curettage revealed an endometrial cancer.
  • Histology showed an endometrioid adenocarcinoma of endometrium stage Ib, moderately differentiated.
  • Although, recurrence on vaginal cuff was possible, the biopsies of anterior vaginal wall showed a poorly differentiated squamous cell carcinoma of the vagina.
  • The patient was classified as stage II vaginal carcinoma and underwent complete radiotherapy and chemotherapy.
  • [MeSH-major] Carcinoma, Endometrioid / diagnosis. Carcinoma, Squamous Cell / diagnosis. Endometrial Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Vaginal Neoplasms / diagnosis

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  • (PMID = 20120445.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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65. Mood NI, Eftekhar Z, Haratian A, Saeedi L, Rahimi-Moghaddam P, Yarandi F: A cytohistologic study of atypical glandular cells detected in cervical smears during cervical screening tests in Iran. Int J Gynecol Cancer; 2006 Jan-Feb;16(1):257-61
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  • Among them were cervical intraepithelial neoplasia, basal cell abnormality of undetermined significance, cervical adenocarcinoma, endometrial hyperplasia or adenocarcinoma, vaginal adenocarcinoma, endocervical glandular dysplasia, metastatic breast carcinoma, and simple nonvillous trophoblastic tissue.
  • The results of the current study underline the importance of follow-up for patients with the diagnosis of AGC.
  • To our knowledge, this is the first report in Iran showing the significance of AGC diagnosis.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / epidemiology. Cervical Intraepithelial Neoplasia / pathology. Cervix Uteri / pathology. Papanicolaou Test. Uterine Cervical Neoplasms / epidemiology. Uterine Cervical Neoplasms / pathology. Vaginal Smears

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  • (PMID = 16445641.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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66. Silva EG, Deavers MT, Bodurka DC, Malpica A: Association of low-grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: a new type of dedifferentiated carcinoma? Int J Gynecol Pathol; 2006 Jan;25(1):52-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • At presentation, the patients had either vaginal bleeding or pelvic pain.
  • Undifferentiated carcinoma was found after resection of low-grade endometrioid carcinoma in six cases, involving the retroperitoneum, pelvis, vagina, or liver.
  • In four cases, the diagnosis was made recently, with short follow-ups of 3 and 4 months.
  • Foci of undifferentiated carcinoma may be confused with solid endometrioid adenocarcinoma erroneously leading to the diagnosis of a grade 3 or a significantly less aggressive grade 2 endometrioid carcinoma.
  • The recognition of undifferentiated carcinoma in an otherwise low-grade endometrioid adenocarcinoma is extremely important because it indicates aggressive behavior.

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  • [ErratumIn] Int J Gynecol Pathol. 2006 Jul;25(3):304
  • (PMID = 16306785.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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67. Klapsinou E, Terzakis E, Arnogiannaki N, Daskalopoulou D: Paget's disease of the vulva detected in vulvar and vaginal brushing smears: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):898-902
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paget's disease of the vulva detected in vulvar and vaginal brushing smears: a case report.
  • CASE: A 75-year-old woman presented with erythematous plaques covering the entire vulvar, vaginal and perianal area and pruritus.
  • Additionally, biopsies were taken from the vulva, vagina and outer borders of the lesion and were stained with hematoxylin-eosin and also for periodic acid-Schiff stain, CK7, CEA, S-100 and CK20.
  • The histologic findings confirmed the cytologic diagnosis.
  • No indication of an underlying adenocarcinoma was found.
  • CONCLUSION: Although the histologic examination of a vulvar lesion is necessary in order to confirm the diagnosis of vulvar Paget's disease and rule out the possibility of an underlying invasive adenocarcinoma, the cytologic examination of vulvar smears is useful for alerting the clinician to the possibility of vulvar Paget's disease.
  • [MeSH-major] Paget Disease, Extramammary / pathology. Papanicolaou Test. Vaginal Smears. Vulva / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 21053565.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Cao L, Li X, Zhang Y, Li X, Wang Q: [Clinical features and prognosis of cervical cancer in young women]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2010 Aug;35(8):875-8
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  • [Title] [Clinical features and prognosis of cervical cancer in young women].
  • OBJECTIVE: To investigate the prevalence, etiology, clinical presentation and pathological features, treatment and prognosis of cervical cancer in young women.
  • METHODS: Clinical data of 132 young women with cervical cancer were reviewed.
  • RESULTS: Positive rate of human papillomavirus 18 was high in young women with cervical cancer.
  • The primary clinical presentation of young patients with cervical cancer was contact bleeding of vagina, and the signs were out-expanding of cervical mass.
  • The percentage of adenocarcinoma increased.
  • The main treatment for cervical cancer was surgery.
  • CONCLUSION: Contact bleeding is a significant symptom in young women with cervical cancer.
  • Preoperative neoadjuvant chemotherapy can be used in patients with locally advanced and late stage cervical cancer.
  • [MeSH-major] Uterine Cervical Neoplasms / diagnosis

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  • (PMID = 20818083.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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69. Driss M, Abid L, Mrad K, Dhouib R, Romdhane KB: Primary vaginal adenocarcinoma of intestinal type arising from an adenoma. J Obstet Gynaecol; 2007 Apr;27(3):332-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary vaginal adenocarcinoma of intestinal type arising from an adenoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Intestinal Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Neoplasm Metastasis

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  • (PMID = 17464837.001).
  • [ISSN] 0144-3615
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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