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1. Gu M, Ghafari Z: Follicular neoplasm of the thyroid gland: unique cytologic appearances in a fine-needle aspiration biopsy. Diagn Cytopathol; 2010 Sep;38(9):660-2
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  • [Title] Follicular neoplasm of the thyroid gland: unique cytologic appearances in a fine-needle aspiration biopsy.
  • Fine-needle aspiration (FNA) biopsy has become a standard first-line diagnostic procedure for palpable and nonpalpable nodules of the thyroid gland.
  • [MeSH-major] Thyroid Gland / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular. Biopsy, Fine-Needle. Humans. Male. Middle Aged. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery

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  • [Copyright] Copyright 2009 Wiley-Liss, Inc.
  • (PMID = 19950399.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. McCain SL, Allender MC, Bohling M, Ramsay EC, Morandi F, Newkirk KM: Thyroid neoplasia in captive raccoons (Procyon lotor). J Zoo Wildl Med; 2010 Mar;41(1):121-7
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  • [Title] Thyroid neoplasia in captive raccoons (Procyon lotor).
  • Two adult, spayed, female raccoons were diagnosed with thyroid neoplasia.
  • One raccoon had a palpable, left-sided, nonfunctional thyroid adenocarcinoma which was treated with a thyroidectomy twice with local recurrence both times.
  • The second raccoon had nonpalpable, bilateral, functional follicular thyroid adenomatous hyperplasia and was treated with a right thyroidectomy and a partial left thyroidectomy, leaving behind the grossly normal portion of the left thyroid.
  • Thyroid pathology has been documented in raccoons in Europe, but is not reported in the United States.
  • Thyroid neoplasia in raccoons can occur as a nonfunctional adenocarcinoma, as is commonly reported in dogs, or as a functional adenoma, as is commonly reported in cats.
  • [MeSH-major] Thyroid Neoplasms / veterinary

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  • (PMID = 20722264.001).
  • [ISSN] 1042-7260
  • [Journal-full-title] Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • [ISO-abbreviation] J. Zoo Wildl. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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3. Marioni G, De Filippis C, Ottaviano G, Lorusso M, Staffieri C, Bernini G, Blandamura S: Laryngeal metastasis from sigmoid colon adenocarcinoma followed by peristomal recurrence. Acta Otolaryngol; 2006 Jun;126(6):661-3
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  • [Title] Laryngeal metastasis from sigmoid colon adenocarcinoma followed by peristomal recurrence.
  • Colonic adenocarcinoma metastases to the larynx are extremely rare: only 13 cases have been described since 1972.
  • We present the first case of sigmoid colon adenocarcinoma metastasis to the larynx in a patient who developed peristomal malignancy recurrence after total laryngectomy.
  • Patients with metastasis of colonic adenocarcinoma to the larynx usually present with disseminated disease: in view of the poor chances of long-term survival of these patients conservative palliative laryngeal treatments should be carried out to improve the quality of life.
  • [MeSH-major] Adenocarcinoma / secondary. Laryngeal Neoplasms / secondary. Laryngectomy. Neoplasm Recurrence, Local / diagnosis. Sigmoid Neoplasms / diagnosis. Tracheostomy
  • [MeSH-minor] Aged. Biopsy, Needle. Female. Humans. Larynx / pathology. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Reoperation. Thyroid Gland / pathology. Thyroid Neoplasms / pathology. Thyroid Neoplasms / secondary. Thyroid Neoplasms / surgery. Thyroidectomy

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  • (PMID = 16720454.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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4. Van den Bruel A, Vauterin T, Poorten VV, Decallonne B: Advances in the medical management of differentiated thyroid carcinoma and their impact on the surgical approach. Acta Chir Belg; 2007 Jun;107(3):271-8
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  • [Title] Advances in the medical management of differentiated thyroid carcinoma and their impact on the surgical approach.
  • The introduction of recombinant human TSH and neck ultrasonography has refined the management of differentiated thyroid cancer, leading to the publication of new guidelines by the American Thyroid Association (ATA) and a consensus report by the European Thyroid Association (ETA) in 2006.
  • In this paper, we give an overview of the current medical management of differentiated thyroid cancer (pre-surgical, post-surgical), of how the advances have been integrated into the recent 2006 ATA guidelines and ETA consensus and finally, of the impact on the surgical management (first surgery, treatment of cervical lymph nodes) of differentiated thyroid cancer.
  • [MeSH-major] Adenocarcinoma, Follicular / surgery. Adenocarcinoma, Papillary / surgery. Adenoma, Oxyphilic / surgery. Lymph Node Excision. Practice Guidelines as Topic. Thyroid Neoplasms / surgery. Thyroidectomy
  • [MeSH-minor] Biopsy, Fine-Needle. Combined Modality Therapy. Consensus. Humans. Iodine Radioisotopes / therapeutic use. Recombinant Proteins / therapeutic use. Thyroid Gland / pathology. Thyrotropin / therapeutic use. Ultrasonography

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  • (PMID = 17685252.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Recombinant Proteins; 9002-71-5 / Thyrotropin
  • [Number-of-references] 20
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5. Sasaki E, Tsunoda N, Hatanaka Y, Mori N, Iwata H, Yatabe Y: Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers. Mod Pathol; 2007 Feb;20(2):208-14
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  • Of the other cancers examined, including 29 of the head and neck, eight of the thyroid, 106 of the lung, 35 of the gastrointestinal tract, three of the pancreas, 14 of the uterine cervix and 13 of the ovary, none were positive for MGB1 except a proportion of salivary gland tumors (6/11, 55%) and endometrial cancers (3/23, 13%).
  • In terms of practical diagnosis, MGB1 immunohistochemistry can serve as a differential marker of breast cancer metastasis from primary lung cancer for two reasons.
  • [MeSH-major] Adenocarcinoma / metabolism. Breast Neoplasms / metabolism. Neoplasm Proteins / metabolism. Uteroglobin / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Count. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunoenzyme Techniques. Japan / epidemiology. Lung Neoplasms / diagnosis. Lung Neoplasms / metabolism. Lung Neoplasms / secondary. Mammaglobin A. Neoplasm Staging. Receptors, Estrogen / metabolism. Survival Rate. Tissue Array Analysis

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  • (PMID = 17192791.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mammaglobin A; 0 / Neoplasm Proteins; 0 / Receptors, Estrogen; 0 / SCGB2A2 protein, human; 9060-09-7 / Uteroglobin
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6. Nunes Vdos S, Tagliarini JV, Marques ME, de Godoi JA, Mazeto GM: A patient with Graves' disease and three types of thyroid carcinoma. Thyroid; 2010 May;20(5):573-4
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  • [Title] A patient with Graves' disease and three types of thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Follicular / complications. Carcinoma / complications. Graves Disease / complications. Thyroid Neoplasms / complications. Thyroid Nodule / complications
  • [MeSH-minor] Aged. Fatal Outcome. Female. Humans. Neoplasm Metastasis / pathology. Thyroid Gland / pathology. Thyroidectomy. Thyrotropin / blood. Thyroxine / blood

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  • (PMID = 20450435.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine
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7. Frew J, Mallick U, Perros P: A patient with asymmetric parotid uptake on a diagnostic iodine-131 scan during thyroid cancer follow-up. Thyroid; 2007 Aug;17(8):801-2
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  • [Title] A patient with asymmetric parotid uptake on a diagnostic iodine-131 scan during thyroid cancer follow-up.
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Carcinoma, Papillary, Follicular / radionuclide imaging. Parotid Gland / radionuclide imaging. Parotid Neoplasms / radionuclide imaging. Thyroid Neoplasms / radionuclide imaging

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  • (PMID = 17725441.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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8. Todaro M, Iovino F, Eterno V, Cammareri P, Gambara G, Espina V, Gulotta G, Dieli F, Giordano S, De Maria R, Stassi G: Tumorigenic and metastatic activity of human thyroid cancer stem cells. Cancer Res; 2010 Nov 1;70(21):8874-85
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  • [Title] Tumorigenic and metastatic activity of human thyroid cancer stem cells.
  • Thyroid carcinoma is the most common endocrine malignancy and the first cause of death among endocrine cancers.
  • We show that the tumorigenic capacity in thyroid cancer is confined in a small subpopulation of stem-like cells with high aldehyde dehydrogenase (ALDH(high)) activity and unlimited replication potential.
  • Orthotopic injection of minute numbers of thyroid cancer stem cells recapitulates the behavior of the parental tumor, including the aggressive metastatic features of undifferentiated thyroid carcinomas, which are sustained by constitutive activation of cMet and Akt in thyroid cancer stem cells.
  • The identification of tumorigenic and metastagenic thyroid cancer cells may provide unprecedented preclinical tools for development and preclinical validation of novel targeted therapies.
  • [MeSH-major] Aldehyde Dehydrogenase / metabolism. Cell Transformation, Neoplastic / pathology. Lung Neoplasms / secondary. Neoplastic Stem Cells / pathology. Thyroid Gland / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / enzymology. Adenocarcinoma, Follicular / pathology. Adult. Aged. Animals. Blotting, Western. Carcinoma / enzymology. Carcinoma / pathology. Carcinoma, Papillary / enzymology. Carcinoma, Papillary / pathology. Case-Control Studies. Cell Adhesion. Cell Movement. Cell Proliferation. Female. Flow Cytometry. Fluorescent Antibody Technique. Humans. Immunoenzyme Techniques. Male. Mice. Mice, Inbred NOD. Mice, Nude. Mice, SCID. Middle Aged. Neoplasm Invasiveness. Proto-Oncogene Proteins c-akt / metabolism. Proto-Oncogene Proteins c-met / metabolism. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction. Tumor Stem Cell Assay. Xenograft Model Antitumor Assays. Young Adult


9. Moslavac S, Matesa N, Kusić Z: Thyroid fine needle aspiration cytology in children and adolescents. Coll Antropol; 2010 Mar;34(1):197-200
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  • [Title] Thyroid fine needle aspiration cytology in children and adolescents.
  • Thyroid fine needle aspiration cytology (FNAC) is the most accurate and cost effective method in the evaluation of the thyroid nodule and has been commonly used in adults.
  • Thyroid nodules are uncommon in younger patients (1-2%).
  • Ultrasound-guided thyroid FNACs performed from May 1995 to June 2008 in patients under 18 years of age were retrospectively reviewed.
  • Cytological parameters included cytologic diagnosis and cyto-pathohistological correlation.
  • Total of 236 cases, representing 206 patients under 18 years of age, were retrieved from a total of 11748 thyroid FNAC cases (2.0%).
  • 20 (35.7%) patients did not have any nodules, 20 (35.7%) patients had solitary thyroid nodule and 16 (28.6%) patients had multiple nodules.
  • The cytologic diagnoses were: unsatisfactory (9), cyst fluid (7), benign (204), cellular follicular lesion/follicular neoplasm (9) and papillary thyroid carcinoma (7).
  • 5 patients (23.8%) had thyroid malignancies (all papillary carcinomas).
  • The remainder had benign thyroid lesions; follicular adenomas (8), multinodular goiters (5), diffuse goiters (2) and Hashimoto thyreoiditis (1).
  • The prevalence of thyroid malignancies among cytologic diagnoses was similar to those reported in adults.
  • [MeSH-major] Biopsy, Fine-Needle / statistics & numerical data. Thyroid Diseases / epidemiology. Thyroid Diseases / pathology. Thyroid Gland / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / epidemiology. Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / surgery. Adolescent. Carcinoma, Papillary / epidemiology. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Child. Child, Preschool. Croatia / epidemiology. Female. Goiter, Nodular / epidemiology. Goiter, Nodular / pathology. Goiter, Nodular / surgery. Hashimoto Disease / epidemiology. Hashimoto Disease / pathology. Hashimoto Disease / surgery. Humans. Male. Prevalence. Reproducibility of Results. Thyroid Neoplasms / epidemiology. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery

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  • (PMID = 20432751.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
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10. Nelson KK, Gattuso P, Xu X, Prinz RA: Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. Surgery; 2010 Oct;148(4):654-60; discussion 660
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  • [Title] Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy.
  • The Sonic Hedgehog pathway is required for normal thyroid gland development, but when activated as a result of gene mutation or overexpression, it may stimulate thyroid tumor cell proliferation.
  • This study determines whether 3 molecules, Patched, Smoothened, and Sonic Hedgehog, involved in the Sonic Hedgehog pathway are overexpressed equally in synchronous follicular thyroid adenoma and papillary thyroid carcinoma.
  • METHODS: Eighteen patients with synchronous follicular thyroid adenoma and papillary thyroid carcinoma underwent thyroidectomy.
  • CONCLUSION: Expression of the 3 molecules involved in the Sonic Hedgehog pathway was similar in follicular thyroid adenoma, but Sonic Hedgehog expression was a more sensitive indicator of malignancy in papillary thyroid carcinoma.
  • Greater understanding of the Sonic Hedgehog pathway may provide molecular methods for preventing or treating papillary thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. Adenoma / metabolism. Hedgehog Proteins / biosynthesis. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasms, Multiple Primary. Predictive Value of Tests. Thyroid Gland / metabolism. Young Adult

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20797751.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / SHH protein, human
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11. Simpson AC, McCown JL: Systemic hypertension in a dog with a functional thyroid gland adenocarcinoma. J Am Vet Med Assoc; 2009 Dec 15;235(12):1474-9
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  • [Title] Systemic hypertension in a dog with a functional thyroid gland adenocarcinoma.
  • Palpation of the ventral cervical region revealed a fixed asymmetric mass in the area of the lobes of the thyroid gland.
  • Thyroidectomy of both lobes of the gland was performed.
  • Histologic examination revealed a bilateral, multilobulated, and encapsulated thyroid gland adenocarcinoma.
  • TREATMENT AND OUTCOME: Thyroidectomy of both lobes of the gland was performed with clinical resolution of hypertension.
  • CLINICAL RELEVANCE: This report describes concurrent hypertension in a dog with a functional thyroid gland adenocarcinoma with subsequent return of blood pressure values to within reference ranges after thyroidectomy.
  • [MeSH-major] Adenocarcinoma / veterinary. Dog Diseases / etiology. Hypertension / veterinary. Thyroid Neoplasms / veterinary

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  • (PMID = 20001784.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q51BO43MG4 / Thyroxine
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12. Mattioli F, Martelli A, Gosmar M, Garbero C, Manfredi V, Varaldo E, Torre GC, Brambilla G: DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by chemicals carcinogenic to the rat thyroid. Mutat Res; 2006 Oct 30;609(2):146-53
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  • [Title] DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by chemicals carcinogenic to the rat thyroid.
  • Five chemicals that are known to induce in rats thyroid follicular-cell adenomas and carcinomas were assayed for their ability to induce DNA damage and DNA repair synthesis in primary cultures of human thyroid cells.
  • Under the same experimental conditions, DNA repair synthesis, as evaluated by quantitative autoradiography, was present in potassium bromate-exposed thyroid cells from all the three donors and in those from two of three donors with either nitrobenzene or ethylenethiourea, but did not match the criteria for a positive response in thyroid cells from any of the donors with methimazole and N,N'-diethylthiourea.
  • Consistently with their ability to induce thyroid tumors, all the five test compounds, administered p.o. in rats in a single dose corresponding to 1/2 LD50, induced a statistically significant degree of DNA fragmentation in the thyroid.
  • These findings suggest that the five test compounds might be carcinogenic to thyroid in humans.
  • [MeSH-major] Carcinogens / toxicity. DNA Fragmentation / drug effects. DNA Repair / drug effects. Thyroid Gland / drug effects. Thyroid Gland / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / chemically induced. Adenoma / chemically induced. Animals. Bromates / toxicity. Cells, Cultured. DNA Damage. Ethylenethiourea / toxicity. Humans. In Vitro Techniques. Kidney / drug effects. Kidney / metabolism. Liver / drug effects. Liver / metabolism. Male. Methimazole / toxicity. Nitrobenzenes / toxicity. Rats. Rats, Sprague-Dawley. Thiourea / analogs & derivatives. Thiourea / toxicity. Thyroid Neoplasms / chemically induced

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  • (PMID = 16942904.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bromates; 0 / Carcinogens; 0 / Nitrobenzenes; 04MB35W6ZA / potassium bromate; 24FOJ4N18S / Ethylenethiourea; 26914-14-7 / diethylthiourea; 554Z48XN5E / Methimazole; E57JCN6SSY / nitrobenzene; GYV9AM2QAG / Thiourea
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13. Cameselle-Teijeiro J: Uncommon tumors of the thyroid gland. Int J Surg Pathol; 2010 Jun;18(3 Suppl):205S-208S
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  • [Title] Uncommon tumors of the thyroid gland.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Carcinoma, Squamous Cell / pathology. Solitary Fibrous Tumors / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Mutation. Receptors, Thyrotropin / genetics

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  • (PMID = 20484292.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Thyrotropin
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14. Tan H, Ye K, Wang Z, Tang H: CD147 expression as a significant prognostic factor in differentiated thyroid carcinoma. Transl Res; 2008 Sep;152(3):143-9
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  • [Title] CD147 expression as a significant prognostic factor in differentiated thyroid carcinoma.
  • The goal of this study was to analyze the expression of CD147 in differentiated thyroid carcinoma (DTC) tissues as well as its association with the clinicopathologic features of DTC patients and its prognostic significance.
  • During our research, CD147 expression in 156 patients who underwent operation for DTC [100 with papillary thyroid carcinoma (PTC) and 56 with follicular thyroid carcinoma (FTC)] were examined by immunostaining on paraffin-embedded tumor specimens.
  • [MeSH-major] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Papillary / metabolism. Antigens, CD147 / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Female. Fluorescent Antibody Technique, Indirect. Humans. Immunoenzyme Techniques. Lymph Nodes / metabolism. Lymph Nodes / pathology. Male. Middle Aged. Prognosis. Survival Rate. Thyroid Gland / metabolism. Thyroid Gland / pathology. Young Adult

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  • (PMID = 18774544.001).
  • [ISSN] 1931-5244
  • [Journal-full-title] Translational research : the journal of laboratory and clinical medicine
  • [ISO-abbreviation] Transl Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BSG protein, human; 0 / Biomarkers, Tumor; 136894-56-9 / Antigens, CD147
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15. Albores-Saavedra J, Wu J: The many faces and mimics of papillary thyroid carcinoma. Endocr Pathol; 2006;17(1):1-18
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  • [Title] The many faces and mimics of papillary thyroid carcinoma.
  • This article provides an overview of the 15 histologic variants of papillary thyroid carcinoma listed by the 2004 World Health Organization (WHO) monograph on endocrine tumors.
  • The histologic features, differential diagnosis, and clinical course of each variant are discussed in some detail.
  • Moreover, hyperplastic thyroid lesions, follicular adenomas, and Hashimoto's thyroiditis may contain cells with clear nuclei resembling those of papillary carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenoma / diagnosis. Cell Nucleus / pathology. Diagnosis, Differential. Hashimoto Disease / diagnosis. Humans. Hyperplasia / diagnosis. Thyroid Gland / pathology. World Health Organization

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  • (PMID = 16760576.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 68
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16. Quinn TR, Duncan LM, Zembowicz A, Faquin WC: Cutaneous metastases of follicular thyroid carcinoma: a report of four cases and a review of the literature. Am J Dermatopathol; 2005 Aug;27(4):306-12
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  • [Title] Cutaneous metastases of follicular thyroid carcinoma: a report of four cases and a review of the literature.
  • Cutaneous metastasis of follicular carcinoma of the thyroid is very rare, and when it occurs, can exhibit a variety of histologic appearances.
  • The cases consisted of 4 patients, 3 men and 1 woman, aged 52 to 75 years, with cutaneous metastasis of follicular thyroid carcinoma.
  • All 4 tumors were widely invasive within the thyroid gland.
  • Three metastases retained the morphologic and immunocytochemical features of the primary thyroid tumors.
  • However, in one case there was high-grade transformation to anaplastic carcinoma following treatment of a sacral metastasis with accompanying loss of the characteristic immunophenotype of follicular thyroid carcinoma.
  • Awareness of the varied morphologies of metastatic follicular thyroid carcinoma to the skin may prompt immunohistochemical analysis and the request for a complete clinical history, ultimately preventing misdiagnosis.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Skin Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 16121050.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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17. Liu Z, Bai Y, Li Y, Ohba K, Nakamura H, Ozaki T, Taniguchi E, Mori I, Kakudo K: Non-solid type thyroid carcinoma: a case report of moderately differentiated adenocarcinoma of the thyroid. Pathol Int; 2010 Jul;60(7):524-7
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  • [Title] Non-solid type thyroid carcinoma: a case report of moderately differentiated adenocarcinoma of the thyroid.
  • We report the case of a common type papillary thyroid carcinoma (PTC) patient who developed early recurrence and persistent disease even after ablation therapy.
  • The patient was an 80-year-old man that was incidentally found to have a mass lesion in the left lower lobe of his thyroid.
  • We recently proposed a new classification for follicular cell tumors of the thyroid gland, and this case is an example of moderately-differentiated adenocarcinoma according to our classification.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 20594275.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Iodine Radioisotopes
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18. Nonaka D, Tang Y, Chiriboga L, Rivera M, Ghossein R: Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms. Mod Pathol; 2008 Feb;21(2):192-200
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  • [Title] Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms.
  • Thyroid-specific transcription factors, Pax8, TTF-1, and TTF-2, are crucial for thyroid organogenesis and differentiation.
  • The goal of this study is to evaluate the expressions of these markers in thyroid tumors of the full spectrum of differentiation, with special emphasis on anaplastic carcinomas.
  • A total of 94 cases of thyroid neoplasms were studied: 17 papillary carcinomas, 18 follicular adenomas, 16 follicular carcinomas, 7 poorly differentiated carcinomas, 28 anaplastic carcinomas, and 8 medullary carcinomas.
  • Pax8 is a useful marker for the diagnosis of anaplastic carcinomas, particularly when the differential diagnosis includes pulmonary carcinoma.
  • In differentiated thyroid neoplasms, no significant difference in expression was seen in all the three transcription factors.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Adenosine Triphosphatases / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Papillary / metabolism. DNA-Binding Proteins / metabolism. Paired Box Transcription Factors / metabolism. Thyroid Neoplasms / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / metabolism. Adolescent. Adult. Aged. Aged, 80 and over. Calcitonin / metabolism. Carcinoma / diagnosis. Carcinoma / metabolism. Carcinoma, Medullary / diagnosis. Carcinoma, Medullary / metabolism. Female. Fluorescent Antibody Technique, Indirect. Humans. Hyperplasia. Immunoenzyme Techniques. Male. Middle Aged. Thyroid Gland / metabolism. Thyroid Gland / pathology. Tissue Array Analysis

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  • (PMID = 18084247.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / PAX8 protein, human; 0 / Paired Box Transcription Factors; 0 / Transcription Factors; 9007-12-9 / Calcitonin; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.1.- / TTF2 protein, human
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19. Roth LM, Miller AW 3rd, Talerman A: Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature. Int J Gynecol Pathol; 2008 Oct;27(4):496-506
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  • [Title] Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature.
  • In this article, we report 3 cases of papillary and 1 of follicular thyroid carcinoma; 2 of these cases were associated with mature cystic teratoma.
  • In regard to the occurrence of thyroid-type carcinoma in struma ovarii, precise terminology should be used, and the expression malignant struma ovarii was avoided as a diagnostic term.
  • Upon review of the literature, papillary carcinoma and follicular carcinoma are the most frequent types of malignancy to occur in ovarian struma; other forms of thyroid carcinoma occur only rarely.
  • The diagnostic criteria for cases of papillary carcinoma are similar to those described in the cervical thyroid gland and are based primarily on nuclear and architectural features.
  • Histological malignancy in a struma does not necessarily equate with biological malignancy, and the majority of thyroid-type carcinomas do not spread beyond the ovary.
  • Because its histological appearance resembles that of nonneoplastic thyroid, HDFCO characteristically cannot be diagnosed until the neoplasm spreads beyond the ovary.
  • In this article, we apply the term typical thyroid carcinoma to those forms of thyroid malignancy arising in ovarian struma that closely resemble the types described in the cervical thyroid gland to distinguish them from HDFCO.
  • Cases of thyroid-type carcinoma arising in the ovary sometimes lack evidence of preexisting struma.
  • The more aggressive thyroid-type neoplasms can arise in thyroid tissue within a mature cystic teratoma, or they may overgrow and replace the struma.
  • Primary thyroid-type carcinoma must be distinguished from rare instances of ovarian metastases that originate in the cervical thyroid gland and the less differentiated forms from other ovarian neoplasms such as clear cell adenocarcinoma and tumors with an oxyphilic appearance.
  • In the differential diagnosis with other ovarian neoplasms, cases of thyroid-type carcinoma associated with strumal carcinoid should not be diagnosed as malignant strumal carcinoid because the latter diagnosis might lead to suboptimal therapy.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Carcinoid Tumor / pathology. Carcinoma, Papillary / pathology. Ovarian Neoplasms / pathology. Struma Ovarii / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18753973.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Jung TS, Oh YL, Min YK, Lee MS, Lee MK, Kim KW, Chung JH: A patient with primary squamous cell carcinoma of the thyroid intermingled with follicular thyroid carcinoma that remains alive more than 8 years after diagnosis. Korean J Intern Med; 2006 Mar;21(1):73-8
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  • [Title] A patient with primary squamous cell carcinoma of the thyroid intermingled with follicular thyroid carcinoma that remains alive more than 8 years after diagnosis.
  • Primary squamous cell carcinoma of the thyroid is an extremely rare tumor with a highly aggressive clinical course.
  • We report here on a patient with primary squamous cell carcinoma of the thyroid who remains alive more than 8 years after diagnosis.
  • A 56-year-old man presented with a hoarse voice and a rapidly progressing mass on the right side of the thyroid gland.
  • Histopathologic findings revealed primary squamous cell carcinoma combined with follicular carcinoma of the thyroid.
  • The patient underwent colectomy for the diagnosis of a colon cancer.
  • Recent evaluation has revealed a new lesion in the lung; this was diagnosed as metastatic follicular carcinoma originating from the thyroid.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Carcinoma, Squamous Cell / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 16646570.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3891069
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21. Ito Y, Arai K, Ryushi, Nozawa, Yoshida H, Tomoda C, Uruno T, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Kakudo K, Miyauchi A: S100A9 expression is significantly linked to dedifferentiation of thyroid carcinoma. Pathol Res Pract; 2005;201(8-9):551-6
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  • [Title] S100A9 expression is significantly linked to dedifferentiation of thyroid carcinoma.
  • In this study, we immunohistochemically investigated S100A9 expression in thyroid neoplasms.
  • It is therefore suggested that S100A4 protein plays an important role in thyroid carcinoma dedifferentiation, and can be considered a novel characteristic of undifferentiated carcinoma.
  • [MeSH-major] Adenocarcinoma, Follicular / metabolism. Adenoma / metabolism. Calgranulin B / metabolism. Carcinoma, Papillary / metabolism. Cell Transformation, Neoplastic / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Immunoenzyme Techniques. Thyroid Gland / metabolism. Thyroid Gland / pathology

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  • (PMID = 16259107.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calgranulin B
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22. Wills TB, Bohn AA, Finch NP, Harris SP, Caplazi P: Thyroid follicular adenocarcinoma in a ferret. Vet Clin Pathol; 2005 Dec;34(4):405-8
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  • [Title] Thyroid follicular adenocarcinoma in a ferret.
  • The cytologic results were most consistent with epithelial neoplasia, likely a carcinoma; thyroid origin was considered likely based on tumor location and cell morphology.
  • At necropsy, a circumscribed, ovoid mass disrupted the right cervical musculature next to the right lobe of the thyroid gland.
  • The histopathologic diagnosis was consistent with thyroid follicular adenocarcinoma.
  • Immunochemical findings confirmed thyroglobulin production by neoplastic cells, but to a lesser extent than in normal ferret thyroid tissue.
  • To our knowledge, this is the first case of thyroid follicular adenocarcinoma to be reported in a ferret, with only 1 other case of thyroid carcinoma, a C-cell carcinoma, described previously.

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  • (PMID = 16270269.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9010-34-8 / Thyroglobulin
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23. Zhang W, Feng S, Yan S, Zhao Y, Li M, Sun J, Zhang FC, Cui Q, Dong Y: Incidence of malignancy in primary Sjogren's syndrome in a Chinese cohort. Rheumatology (Oxford); 2010 Mar;49(3):571-7
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  • Different types of malignancy were observed including eight lymphomas, two myeloid myelomas and 19 solid tumours, which consisted of invasive thymoma, breast cancer, lung cancer, gastrointestinal adenocarcinoma, hepatoma, squamous cell carcinoma of tongue, uterine cervix cancer, renal carcinoma, thyroid carcinoma and mucoepidermoid carcinoma of parotid gland.

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  • (PMID = 20040528.001).
  • [ISSN] 1462-0332
  • [Journal-full-title] Rheumatology (Oxford, England)
  • [ISO-abbreviation] Rheumatology (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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24. Pineda-Daboin K, Neto A, Ochoa-Perez V, Luna MA: Nasopharyngeal adenocarcinomas: a clinicopathologic study of 44 cases including immunohistochemical features of 18 papillary phenotypes. Ann Diagn Pathol; 2006 Aug;10(4):215-21
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  • There were 28 salivary gland type, 13 conventional low-grade papillary NPACs of surface origin, and 3 metastatic adenocarcinomas, 2 thyroid and 1 lung.
  • Two of the low-grade papillary NPACs simulated thyroid carcinoma; they expressed CK7, CK19, and TTF-1 but were negative for thyroglobulin.
  • In contrast, 18 (64.2%) of the 28 patients with salivary gland-type NPACs had died of the disease or were living with disease at follow-up.
  • Primary NPACs can be classified by their morphology and clinical behavior into 2 groups: surface origin type and salivary gland type.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Immunoenzyme Techniques / methods. Nasopharyngeal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Phenotype. Retrospective Studies. Salivary Glands / chemistry. Salivary Glands / pathology. Survival Rate. Thyroid Neoplasms / diagnosis

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  • (PMID = 16844563.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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25. Pacini F, Schlumberger M, Dralle H, Elisei R, Smit JW, Wiersinga W, European Thyroid Cancer Taskforce: European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur J Endocrinol; 2006 Jun;154(6):787-803
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  • [Title] European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium.

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  • [ErratumIn] Eur J Endocrinol. 2006 Aug;155(2):385
  • (PMID = 16728537.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Consensus Development Conference; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Iodine Radioisotopes; 9010-34-8 / Thyroglobulin
  • [Number-of-references] 116
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26. Oertel YC: Fine needle aspiration of the thyroid: a pathologist's perspective. J Clin Pathol; 2008 Jul;61(7):785-6
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  • [Title] Fine needle aspiration of the thyroid: a pathologist's perspective.
  • [MeSH-major] Thyroid Gland / pathology. Thyroid Nodule / pathology
  • [MeSH-minor] Adenocarcinoma. Biopsy, Needle / methods. Clinical Competence. Communication. Humans. Interprofessional Relations. Lung Neoplasms. Patient Selection

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  • (PMID = 18430756.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] Adenocarcinoma of lung
  • [Number-of-references] 7
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27. Lee S, Hong SW, Moon WC, Oh MR, Lee JK, Ahn CW, Cha BS, Kim KR, Lee HC, Lim SK: High prevalence of c-RET expression in papillary thyroid carcinomas from the Korean population. Thyroid; 2005 Mar;15(3):259-66
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  • [Title] High prevalence of c-RET expression in papillary thyroid carcinomas from the Korean population.
  • BACKGROUND: Activation of the RET proto-oncogene, located on the long arms of chromosome 10, contributes to the development of thyroid cancers in two different ways.
  • First, somatic rearrangements of RET with variable activation genes are frequently found in papillary thyroid carcinomas.
  • Second, germ-line point mutations are responsible for the development of medullary thyroid carcinomas and multiple endocrine neoplasia type 2 (MEN 2).
  • There are several conflicting reports on the influences of RET expression and RET/PTC rearrangements on the clinical outcome of thyroid cancers.
  • Therefore, the wild-type RET gene expression and RET/PTC-1, RET/PTC-2, RET/PTC-3 rearrangements were examined in thyroid carcinomas and other thyroid diseases.
  • MATERIALS AND METHODS: Thirty-six papillary thyroid carcinomas (PTCs), 8 follicular thyroid carcinomas (FTCs), 4 anaplastic thyroid carcinomas (ATC), 7 follicular adenomas (FAs), 23 hyperplasias, 6 normal thyroid tissues, and 39 normal portions from each tumor were included in this study.
  • No RET gene expression was observed in ATCs, FAs, or normal thyroid tissues.
  • The immunohistochemical results revealed that 66.7% of PTCs, 28.6% of FAs, and 18.2% of hyperplastic thyroid tissue specimens showed high levels of RET protein expression.
  • Neither the normal thyroid tissues nor the FTCs and ATC, showed high levels of RET protein expression.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Asian Continental Ancestry Group / genetics. DNA Primers. Humans. Immunohistochemistry. Korea. Prevalence. Reverse Transcriptase Polymerase Chain Reaction. Thyroid Gland / pathology

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  • (PMID = 15785245.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers
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28. Tavangar SM, Monajemzadeh M, Larijani B, Haghpanah V: Immunohistochemical study of oestrogen receptors in 351 human thyroid glands. Singapore Med J; 2007 Aug;48(8):744-7
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  • [Title] Immunohistochemical study of oestrogen receptors in 351 human thyroid glands.
  • INTRODUCTION: It is well recognised that the pathogenesis of thyroid diseases is complex and different factors such as genetic factors, iodine deficiency, sex, age, radiation therapy in childhood, growth stimulating antibodies, and other epithelial growth factors can influence them.
  • Epidemiological features of thyroid tumours and experimental evidence suggest that female sex hormones may exert effects on the thyroid gland and its neoplasms.
  • This possibility was addressed by investigating the expression of oestrogen receptor protein in 351 thyroid lesions.
  • METHODS: The tissues from 351 human thyroid glands comprising 130 nodular goitres and 221 neoplastic lesions were used for the present immunohistochemical assessment of oestrogen receptor expression.
  • The incidence of oestrogen receptor positivity, which is compatible with other studies, is higher in well-differentiated thyroid lesions.
  • CONCLUSION: The relatively high proportion of oestrogen receptor positivity in goitres, follicular adenomas and papillary carcinomas, compared with its reactivity in other thyroid neoplasms, and contrasted against normal thyroid tissue, suggests that the incidence of oestrogen receptor reactivity tends to increase with better differentiation of thyroid lesions.
  • [MeSH-major] Goiter / metabolism. Receptors, Estrogen / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenoma / metabolism. Adult. Carcinoma, Papillary / metabolism. Female. Humans. Immunohistochemistry. Male

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  • (PMID = 17657383.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Receptors, Estrogen
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29. Blankenship DR, Chin E, Terris DJ: Contemporary management of thyroid cancer. Am J Otolaryngol; 2005 Jul-Aug;26(4):249-60
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  • [Title] Contemporary management of thyroid cancer.
  • Thyroid cancer is a relatively common and frequently curable malignant neoplasm, accounting for nearly 2% of all new cancers diagnosed annually in the United States.
  • We sought to review the epidemiology and pathology of the several types of thyroid cancer and to present our evidence-based management algorithm.
  • In addition to reviewing well-established approaches to diagnosis and management, emphasis is placed on newer techniques, including minimally invasive thyroidectomy, molecular detection of disease propensity, and the use of recombinant thyrotropin prior to radioiodine ablation.
  • [MeSH-major] Thyroid Neoplasms
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / therapy. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / therapy. Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / therapy. Biopsy, Fine-Needle. Carcinoma / diagnosis. Carcinoma / pathology. Carcinoma / therapy. Carcinoma, Medullary / diagnosis. Carcinoma, Medullary / pathology. Carcinoma, Medullary / therapy. Evidence-Based Medicine. Humans. Lymphoma / diagnosis. Lymphoma / pathology. Lymphoma / therapy. Thyroid Gland / anatomy & histology. Thyroid Gland / embryology. Thyroid Gland / radionuclide imaging. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15991091.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 90
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30. Puente S, Velasco A, Gallel P, Pallares J, Perez-Ruiz L, Ros S, Maravall J, Matias-Guiu X: Metastatic small cell carcinoma to the thyroid gland: a pathologic and molecular study demonstrating the origin in the urinary bladder. Endocr Pathol; 2008;19(3):190-6
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  • [Title] Metastatic small cell carcinoma to the thyroid gland: a pathologic and molecular study demonstrating the origin in the urinary bladder.
  • Small cell carcinomas may occur in the thyroid gland.
  • Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma.
  • However, the vast majority of small cell carcinomas involving the thyroid gland are metastatic tumors.
  • An example of a small cell carcinoma metastatic to the thyroid is presented in this report.
  • The microscopical and immunohistochemical features of both tumors, in the thyroid and the bladder, were identical.
  • [MeSH-major] Carcinoma, Small Cell / genetics. Carcinoma, Small Cell / secondary. Thyroid Neoplasms / genetics. Thyroid Neoplasms / secondary. Urinary Bladder Neoplasms / genetics. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Base Sequence. Carcinoma, Transitional Cell / pathology. DNA Methylation. DNA Mutational Analysis. Humans. Immunohistochemistry. Loss of Heterozygosity. Male. Middle Aged. Neoplasms, Multiple Primary / pathology. Promoter Regions, Genetic / genetics. Prostatic Neoplasms / pathology. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 18446450.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Stulík J, Kozák J, Sebesta P, Vyskocil T, Kryl J, Pelichovská M: Total spondylectomy of C2: a new surgical technique. Acta Chir Orthop Traumatol Cech; 2007 Apr;74(2):79-90
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  • We decided to perform a radical surgery in a man, now 27 y. o., with solitary metastasis of thyroid adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Cervical Vertebrae / surgery. Orthopedic Procedures / methods. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Humans. Male. Thyroid Neoplasms / pathology

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  • (PMID = 17493408.001).
  • [ISSN] 0001-5415
  • [Journal-full-title] Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca
  • [ISO-abbreviation] Acta Chir Orthop Traumatol Cech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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32. Cetta F, Dhamo A, Malagnino G, Barellini L: Germ-line and somatic mutations of the APC gene and/or ss catenin gene in the occurrence of FAP associated thyroid carcinoma. World J Surg; 2007 Jun;31(6):1366-7; author reply 1368-9
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  • [Title] Germ-line and somatic mutations of the APC gene and/or ss catenin gene in the occurrence of FAP associated thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Adenomatous Polyposis Coli / genetics. Genes, APC. Germ-Line Mutation / genetics. Mutation / genetics. Thyroid Neoplasms / genetics. beta Catenin / genetics
  • [MeSH-minor] 5' Flanking Region / genetics. Codon. Exons. Genetic Testing. Humans. Hypertrophy / genetics. Loss of Heterozygosity. Pigment Epithelium of Eye / abnormalities. Pigment Epithelium of Eye / pathology. Thyroid Gland / pathology

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  • [CommentOn] World J Surg. 2006 May;30(5):775-9 [16680592.001]
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  • (PMID = 17426899.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Codon; 0 / beta Catenin
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33. Cho NL, Lin CI, Whang EE, Carothers AM, Moore FD Jr, Ruan DT: Sulindac reverses aberrant expression and localization of beta-catenin in papillary thyroid cancer cells with the BRAFV600E mutation. Thyroid; 2010 Jun;20(6):615-22
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  • [Title] Sulindac reverses aberrant expression and localization of beta-catenin in papillary thyroid cancer cells with the BRAFV600E mutation.
  • BACKGROUND: Activation of the Wnt/beta-catenin signaling pathway is implicated in thyroid tumorigenesis, and up to 90% of papillary thyroid cancer (PTC) demonstrate aberrant expression of beta-catenin.
  • In this study, we tested the hypothesis that the nonsteroidal antiinflammatory drug sulindac would reverse aberrant beta-catenin activity in thyroid cancer cells.
  • METHODS: beta-catenin protein levels were determined in thyroidectomy specimens from six consecutive patients and in three different thyroid cancer cells lines (8505-C, KTC-1, and TPC-1) by immunoblotting.
  • PCCL3 rat thyroid cells that conditionally overexpress either BRAF(V600E) or RET/PTC were also treated with sulindac.
  • Future studies should investigate the potential for beta-catenin-directed therapy for patients with advanced thyroid cancers.
  • [MeSH-major] Sulindac / pharmacology. Thyroid Neoplasms / metabolism. beta Catenin / genetics
  • [MeSH-minor] Adenocarcinoma, Papillary / genetics. Adenocarcinoma, Papillary / metabolism. Animals. Cell Line, Tumor. Humans. Mutation. Proto-Oncogene Proteins B-raf / genetics. Rats. Thyroid Gland / drug effects. Thyroid Gland / metabolism


34. Ulisse S, Delcros JG, Baldini E, Toller M, Curcio F, Giacomelli L, Prigent C, Ambesi-Impiombato FS, D'Armiento M, Arlot-Bonnemains Y: Expression of Aurora kinases in human thyroid carcinoma cell lines and tissues. Int J Cancer; 2006 Jul 15;119(2):275-82
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  • [Title] Expression of Aurora kinases in human thyroid carcinoma cell lines and tissues.
  • An increase in the protein level of the 3 kinases was found, with respect to normal human thyrocytes (HTU5), in the human cell lines derived from follicular (FTC-133), papillary (B-CPAP) and anaplastic (8305C) thyroid carcinomas, but not in cells derived from a follicular adenoma (HTU42).
  • The expression at the protein level of all 3 Aurora kinases was significantly higher in 3 thyroid papillary carcinomas with respect to normal matched tissues obtained from the same patients.
  • In conclusion, we demonstrated that normal human thyrocytes express all 3 members of the Aurora kinase family, and their expression is amplified in malignant thyroid cell lines and tissues.
  • These results suggest that the Aurora kinases may play a relevant role in malignant thyroid cancers, and may represent a putative therapeutic target for thyroid neoplasms.
  • [MeSH-major] Carcinoma / enzymology. Protein-Serine-Threonine Kinases / analysis. Thyroid Gland / enzymology. Thyroid Neoplasms / enzymology
  • [MeSH-minor] Adenocarcinoma, Follicular / enzymology. Aurora Kinase C. Aurora Kinases. Carcinoma, Papillary / enzymology. Cell Cycle. Cell Line, Tumor / enzymology. Cell Transformation, Neoplastic. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] 2006 Wiley-Liss, Inc.
  • (PMID = 16477625.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 2.7.11.1 / AURKC protein, human; EC 2.7.11.1 / Aurora Kinase C; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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35. Taylor AJ, Croft AP, Palace AM, Winter DL, Reulen RC, Stiller CA, Stevens MC, Hawkins MM: Risk of thyroid cancer in survivors of childhood cancer: results from the British Childhood Cancer Survivor Study. Int J Cancer; 2009 Nov 15;125(10):2400-5
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  • [Title] Risk of thyroid cancer in survivors of childhood cancer: results from the British Childhood Cancer Survivor Study.
  • Thyroid SPNs can develop after exposure to low-dose radiation, due to the radio-sensitivity of the thyroid gland.
  • We carried out a cohort analysis to determine the risk of thyroid SPNs in the BCCSS, and estimated risk using standardised incidence ratios (SIRs), relative risk (RR) using multivariate Poisson regression and cumulative incidence curves.
  • We identified 50 thyroid SPNs including 31 (62%) papillary carcinomas, 15 (30%) follicular carcinomas and 4 (8%) other types.
  • 88% of thyroid SPNs developed after exposure to radiotherapy in or around the thyroid gland.
  • Risk of thyroid cancer was highest after Hodgkin's disease: RR 3.3 (1.1-10.1) and Non Hodgkin's Lymphoma: RR 3.4 (1.1-10.7) relative to leukaemia (RR 1.0) (p < 0.001).
  • In conclusion, the risk of thyroid cancer in childhood cancer survivors is relatively high in this cohort of childhood cancer survivors.
  • These results will be of use in counselling survivors of childhood cancer exposed to radiation in or around the thyroid area.
  • [MeSH-major] Neoplasms, Radiation-Induced / epidemiology. Neoplasms, Second Primary / epidemiology. Thyroid Gland / radiation effects. Thyroid Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / etiology. Adenocarcinoma, Follicular / epidemiology. Adenocarcinoma, Follicular / etiology. Adolescent. Adult. Carcinoma, Papillary / epidemiology. Carcinoma, Papillary / etiology. Child. Cohort Studies. Dose-Response Relationship, Radiation. Female. Great Britain / epidemiology. Humans. Male. Middle Aged. Prognosis. Risk Assessment. Risk Factors. Survival Rate. Survivors. Young Adult


36. Tsybrovskyy O, Rössmann-Tsybrovskyy M: Oncocytic versus mitochondrion-rich follicular thyroid tumours: should we make a difference? Histopathology; 2009 Dec;55(6):665-82
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  • [Title] Oncocytic versus mitochondrion-rich follicular thyroid tumours: should we make a difference?
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenoma / pathology. Mitochondria / pathology. Oxyphil Cells / pathology. Thyroid Neoplasms / classification. Thyroid Neoplasms / pathology
  • [MeSH-minor] Cell Count. Disease-Free Survival. Humans. Immunohistochemistry. Microscopy, Electron. Regression Analysis. Statistics, Nonparametric. Survival Analysis. Thyroid Gland / metabolism. Thyroid Gland / pathology. Tissue Array Analysis

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  • (PMID = 20002768.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. Cho Mar K, Eimoto T, Tateyama H, Arai Y, Fujiyoshi Y, Hamaguchi M: Expression of matrix metalloproteinases in benign and malignant follicular thyroid lesions. Histopathology; 2006 Feb;48(3):286-94
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  • [Title] Expression of matrix metalloproteinases in benign and malignant follicular thyroid lesions.
  • AIMS: To examine expression of matrix metalloproteinases (MMPs) and related proteins in follicular thyroid lesions (FTLs) and to determine their usefulness for differential diagnosis of FTLs, particularly between minimally invasive carcinoma and adenoma.
  • [MeSH-major] Adenocarcinoma, Follicular / chemistry. Adenoma / chemistry. Matrix Metalloproteinases / analysis. Thyroid Neoplasms / chemistry
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. In Situ Hybridization. Male. Matrix Metalloproteinase 2 / analysis. Matrix Metalloproteinase 2 / genetics. Matrix Metalloproteinase 7 / analysis. Matrix Metalloproteinase 7 / genetics. Middle Aged. Neoplasm Invasiveness. RNA, Messenger / analysis. Thyroid Gland / chemistry. Thyroid Gland / pathology

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  • (PMID = 16430475.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.24 / Matrix Metalloproteinase 2
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38. Cavicchi O, Piccin O, Caliceti U, De Cataldis A, Pasquali R, Ceroni AR: Transient hypoparathyroidism following thyroidectomy: a prospective study and multivariate analysis of 604 consecutive patients. Otolaryngol Head Neck Surg; 2007 Oct;137(4):654-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: The purpose of this study was to identify the risk factors for postoperative transient hypoparathyroidism in a group of patients undergoing thyroid surgery.
  • STUDY DESIGN: A prospective study was conducted on 604 patients undergoing thyroid surgery.
  • SUBJECTS AND METHODS: Gender, final diagnosis, extent of resection, biology of pathology, intrathoracic involvement, surgery for recurrent multinodular goiter, and presence and number of parathyroid glands in a surgical specimen were analyzed as risk factors for postoperative transient hypoparathyroidism.
  • CONCLUSION: The extent of surgery to central and/or lateral neck lymph nodes is responsible for a high rate of transient hypoparathyroidism owing to a high probability of unplanned parathyroidectomy or parathyroid gland devascularization.
  • [MeSH-minor] Adenocarcinoma, Follicular / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / surgery. Child. Female. Follow-Up Studies. Goiter, Nodular / surgery. Goiter, Substernal / surgery. Graves Disease / surgery. Humans. Male. Middle Aged. Neck Dissection / adverse effects. Parathyroidectomy / adverse effects. Prospective Studies. Recurrence. Reoperation. Risk Factors. Thyroid Neoplasms / surgery

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  • (PMID = 17903586.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. McLaughlin PJ, Zagon IS, Park SS, Conway A, Donahue RN, Goldenberg D: Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis. BMC Cancer; 2009;9:369
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  • [Title] Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis.
  • BACKGROUND: Carcinoma of the thyroid gland is an uncommon cancer, but the most frequent malignancy of the endocrine system.
  • Most thyroid cancers are derived from the follicular cell.
  • Follicular carcinoma (FTC) is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers.
  • Both the peptide and receptor have been detected in a wide variety of cancers, and OGF is currently used clinically as a biotherapy for some non-thyroid neoplasias.
  • This study addressed the question of whether the OGF-OGFr axis is present and functional in human thyroid follicular cell - derived cancer.
  • The ubiquity of the OGF-OGFr axis in thyroid follicular cell-derived cancer was assessed in KTC-1 (PTC) and WRO 82-1 (FTC) tumor cells.
  • CONCLUSION: These data suggest that OGF and OGFr are present in follicular-derived thyroid cancers, and that OGF serves in a tonically active inhibitory manner to maintain homeostasis of cell proliferation.
  • [MeSH-major] Adenocarcinoma, Follicular / metabolism. Cell Proliferation. Enkephalin, Methionine / metabolism. Receptors, Opioid / metabolism. Thyroid Neoplasms / metabolism

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  • (PMID = 19835629.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Opioid; 0 / methionine-enkephalin receptor; 58569-55-4 / Enkephalin, Methionine
  • [Other-IDs] NLM/ PMC2770570
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40. Eberhardt NL, Grebe SK, McIver B, Reddi HV: The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer. Mol Cell Endocrinol; 2010 May 28;321(1):50-6
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  • [Title] The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer.
  • When identified at early stages, most well-differentiated thyroid cancers are readily treated and yield excellent outcomes.
  • Follicular thyroid cancer (FTC) however, when diagnosed at a late stage, may be very resistant to treatment, and exhibits 10-year survival rates less than 40%.
  • Despite substantial progress in recent years, we still have limited understanding of the molecular and biological interrelationships between the various subtypes of benign and malignant follicular thyroid neoplasms.
  • In contrast to the wealth of information available regarding papillary thyroid carcinoma (PTC), the triggering mechanisms of FTC development and the major underlying genetic alterations leading to follicular thyroid carcinogenesis remain obscure.
  • Recent studies have focused on a chromosomal translocation, t(2;3) (q13;p25), fusing PAX8, a transcription factor that is essential for normal thyroid gland development, with the peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the steroid/thyroid nuclear receptor family.

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
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  • (PMID = 19883731.001).
  • [ISSN] 1872-8057
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA080117-08; United States / NCI NIH HHS / CA / R01 CA080117-08
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / PAX8-PPARgamma fusion protein, human; 0 / PPAR gamma; 0 / Paired Box Transcription Factors
  • [Number-of-references] 85
  • [Other-IDs] NLM/ NIHMS161308; NLM/ PMC2849860
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41. Pomérance M, Quillard J, Chantoux F, Young J, Blondeau JP: High-level expression, activation, and subcellular localization of p38-MAP kinase in thyroid neoplasms. J Pathol; 2006 Jul;209(3):298-306
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  • [Title] High-level expression, activation, and subcellular localization of p38-MAP kinase in thyroid neoplasms.
  • The present study has investigated the expression, subcellular localization, phosphorylation, and activity of p38-MAPKs in normal and tumoural human thyroid tissues and in thyroid cell lines.
  • The expression and nucleo-cytosolic compartmentalization of the alpha-isoform of p38-MAPKs (p38alpha-MAPK) were studied by western blotting in the WRO and B-CPAP cell lines, which are derived from human follicular and papillary thyroid carcinomas, respectively, and in the non-transformed rat thyroid cell lines FRTL-5 and PCCL3.
  • Immunohistochemistry was used to study the expression and subcellular localization of p38alpha-MAPK, and of the phosphorylated forms of p38-MAPKs (P-p38-MAPKs) in human toxic adenomas (TAs), follicular adenomas (FAs), papillary thyroid carcinomas (PTCs), and follicular thyroid carcinomas (FTCs).
  • Taken together, these results show for the first time that the p38-MAPK signalling cascade is functional in two types of differentiated carcinoma of the thyroid.
  • The observation that p38-MAPK hyper-expression occurs in FTC, but not in FA, may provide an additional diagnostic tool for malignancy in some thyroid nodules.
  • [MeSH-major] Thyroid Neoplasms / enzymology. p38 Mitogen-Activated Protein Kinases / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / enzymology. Adenoma / enzymology. Animals. Carcinoma, Papillary / enzymology. Cell Nucleus / enzymology. Cytosol / enzymology. DNA, Neoplasm / biosynthesis. Enzyme Inhibitors / pharmacology. Humans. Imidazoles / pharmacology. Immunoenzyme Techniques. Phosphorylation. Pyridines / pharmacology. Rats. Thyroid Gland / enzymology. Tumor Cells, Cultured

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  • [Copyright] Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
  • [CommentIn] J Pathol. 2006 Sep;210(1):133-4 [16826548.001]
  • (PMID = 16583356.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Enzyme Inhibitors; 0 / Imidazoles; 0 / Pyridines; 0 / SB 203580; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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42. Laghmari M, El-Fadl SH, Gana R, Maaqili MR, Bellakhdar F: [Late cervicodorsal metastasis of thyroid adenocarcinoma treated by anterior cervicotomy]. Neurochirurgie; 2006 Dec;52(6):537-41
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  • [Title] [Late cervicodorsal metastasis of thyroid adenocarcinoma treated by anterior cervicotomy].
  • Metastasis from a thyroid adenocarcinoma is a rare entity with high mortality.
  • The histological diagnosis was follicular adenocarcinoma.
  • The development of a vertebral metastasis from a thyroid adenocarcinoma 11 years after the treatment of the primitive cancer is rare.
  • [MeSH-major] Adenocarcinoma / pathology. Cervical Vertebrae / pathology. Spinal Neoplasms / secondary. Spinal Neoplasms / surgery. Thyroid Neoplasms / pathology

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  • (PMID = 17203903.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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43. Jogai S, Al-Jassar A, Temmim L, Dey P, Adesina AO, Amanguno HG: Fine needle aspiration cytology of the thyroid: a cytohistologic study with evaluation of discordant cases. Acta Cytol; 2005 Sep-Oct;49(5):483-8
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  • [Title] Fine needle aspiration cytology of the thyroid: a cytohistologic study with evaluation of discordant cases.
  • OBJECTIVE: To analyze the diagnostic efficacy of fine needle aspiration cytology (FNAC) in the initial evaluation of thyroid nodules, with special emphasis on discrepant cytologic diagnoses.
  • STUDY DESIGN: A total of 192 thyroid fine needle aspirates with subsequent histopathologic follow-up were analyzed.
  • The cytologic diagnoses were divided into 4 categories: positive for malignancy, negative for malignancy, indeterminate for diagnosis and nondiagnostic.
  • A false positive diagnosis was made in 1 case (0.5%), proven a follicular adenoma on histopathologic examination.
  • A false negative diagnosis was seen in 3.6% of cases.
  • CONCLUSION: FNAC is a safe, sensitive and specific technique in the initial evaluation of thyroid nodules.
  • A correct cytologic diagnosis can be achieved in a majority of cases, thus obviating the need for a second surgical intervention.
  • [MeSH-major] Diagnostic Errors / prevention & control. Epithelial Cells / pathology. Thyroid Gland / pathology. Thyroid Neoplasms / pathology. Thyroid Nodule / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Adult. Aged. Biopsy, Fine-Needle / standards. Diagnosis, Differential. False Negative Reactions. False Positive Reactions. Female. Humans. Male. Middle Aged. Observer Variation. Predictive Value of Tests. Reproducibility of Results. Retrospective Studies

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  • (PMID = 16334023.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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44. Kumar PV, Monabati A, Tabei SZ, Ramzy M, Husseini SV, Khajeh F: Metastatic follicular thyroid carcinoma diagnosed by fine needle aspiration cytology: a report of 3 cases. Acta Cytol; 2005 Mar-Apr;49(2):177-80
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  • [Title] Metastatic follicular thyroid carcinoma diagnosed by fine needle aspiration cytology: a report of 3 cases.
  • BACKGROUND: Follicular thyroid carcinomas (FTCs) usually have a benign clinical course, with an excellent long-term prognosis and a propensity for vascular invasion.
  • CASES: A 68-year-old man presented with a thyroid mass and skin nodule on the scalp.
  • CONCLUSION: Cytologic diagnosis of metastatic FTC has been reported rarely.
  • Marginal (fire-flare) vacuoles aid in making the diagnosis of metastatic FTC.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Bone Marrow Neoplasms / secondary. Thyroid Gland / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 15839624.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Dohán O, De la Vieja A, Carrasco N: Hydrocortisone and purinergic signaling stimulate sodium/iodide symporter (NIS)-mediated iodide transport in breast cancer cells. Mol Endocrinol; 2006 May;20(5):1121-37
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  • The sodium/iodide symporter (NIS) mediates a remarkably effective targeted radioiodide therapy in thyroid cancer; this approach is an emerging candidate for treating other cancers that express NIS, whether endogenously or by exogenous gene transfer.
  • Therapeutic efficacy in thyroid cancer requires that radioiodide uptake be maximized in tumor cells by manipulating well-known regulatory factors of NIS expression in thyroid cells, such as TSH, which stimulates NIS expression via cAMP.
  • Similarly, therapeutic efficacy in breast cancer will likely depend on manipulating NIS regulation in mammary cells, which differs from that in the thyroid.
  • Human breast adenocarcinoma MCF-7 cells modestly express endogenous NIS when treated with all-trans-retinoic acid (tRa).
  • Surprisingly, the adenyl cyclase activator forskolin, which promotes NIS expression in thyroid cells, markedly decreases tRa-induced NIS protein expression in MCF-7 cells.
  • We also observed that neither iodide, which at high concentrations down-regulates NIS in the thyroid, nor cAMP has a significant effect on NIS expression in MCF-7 cells.
  • [MeSH-minor] 1-Methyl-3-isobutylxanthine / pharmacology. Adenylyl Cyclase Inhibitors. Adenylyl Cyclases / pharmacology. Biological Transport / drug effects. Cell Membrane / metabolism. Cells, Cultured. Colforsin / pharmacology. Female. Humans. Phosphodiesterase Inhibitors / pharmacology. Signal Transduction. Thyroid Gland / metabolism. Tretinoin / pharmacology

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  • (PMID = 16439463.001).
  • [ISSN] 0888-8809
  • [Journal-full-title] Molecular endocrinology (Baltimore, Md.)
  • [ISO-abbreviation] Mol. Endocrinol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA098390
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenylyl Cyclase Inhibitors; 0 / Iodides; 0 / Phosphodiesterase Inhibitors; 0 / Symporters; 0 / sodium-iodide symporter; 1F7A44V6OU / Colforsin; 5688UTC01R / Tretinoin; 8L70Q75FXE / Adenosine Triphosphate; EC 4.6.1.1 / Adenylyl Cyclases; TBT296U68M / 1-Methyl-3-isobutylxanthine; WI4X0X7BPJ / Hydrocortisone
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46. Kupferman ME, Weinstock YE, Santillan AA, Mishra A, Roberts D, Clayman GL, Weber RS: Predictors of level V metastasis in well-differentiated thyroid cancer. Head Neck; 2008 Nov;30(11):1469-74
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  • [Title] Predictors of level V metastasis in well-differentiated thyroid cancer.
  • To identify clinical and pathological predictors of cervical node metastases to level V in differentiated thyroid carcinoma, we reviewed our experience at The University of Texas M. D.
  • Anderson Cancer Center for the management of metastatic well-differentiated thyroid cancer.
  • METHODS: We retrospectively analyzed 70 patients who underwent thyroidectomy and neck dissection for well-differentiated thyroid cancer at M. D.
  • RESULTS: In our series, 53% of neck specimens harbored metastatic thyroid carcinoma at level V.
  • CONCLUSION: In our series, cervical metastases from differentiated thyroid carcinoma were commonly present at level V.
  • Patients with multifocal cancer within the thyroid gland, and cervical metastases in the ipsilateral jugular nodes have a higher risk of harboring metastatic disease at level V.
  • We believe that routine dissection of the level V lymph nodes should be performed in the setting of a comprehensive neck dissection for patients with lateral neck metastasis from well-differentiated thyroid cancer.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Adenocarcinoma, Papillary / secondary. Neck Dissection. Thyroid Neoplasms / pathology

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.
  • (PMID = 18704973.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Xu L, Zhong F, Guo FF, Zhao WJ, Sun XR, Wei XF: [Expression of motilin and its precursor mRNA in normal parenchyma, benign and malignant tumors of human thyroid]. Zhonghua Bing Li Xue Za Zhi; 2008 Apr;37(4):243-9
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  • [Title] [Expression of motilin and its precursor mRNA in normal parenchyma, benign and malignant tumors of human thyroid].
  • OBJECTIVE: To investigate the expression of motilin and its precursor mRNA in normal human thyroid.
  • To compare the expression differences of motilin and it precursor mRNA between normal thyroid and intestines.
  • To study the expression of motilin and its precursor mRNA in human thyroid tumors and their clinical implications.
  • METHODS: RT-PCR, Southern blot and molecular cloning were used to detect motilin transcript expression in human thyroid and mucous membrane of small intestine.
  • Real-time PCR and immunohistochemical techniques were used to quantify motilin precursor mRNA and motilin peptide in thyroid tissue samples including adenoma, medullary carcinoma, follicular carcinoma, papillary carcinoma and nodular goiter. RESULTS:.
  • (1) The expression of motilin and its precursor mRNA in normal human thyroid was primarily in the thyroid C cells. (2) RT-PCR and Southern blot showed that motilin mRNA expressed in human thyroid was identical to that expressed in duodenum with identical sequence deposited in NCBI Genbank of America. (3) Immunohistochemistry, Western blot research and real-time PCR studies showed that motilin and its precursor mRNA were expressed in normal and tumor tissues of human thyroid.
  • Thyroid tumors (acidophilic adenoma, medullary carcinoma, follicular carcinoma, papillary carcinoma and nodular goiter) showed intense and diffuse immunostaining for motilin peptide.
  • Moreover, the expression of motilin and its precursor mRNA in thyroid medullar carcinoma and acidophilic adenoma were significantly higher than those of normal thyroid tissue (P < 0.05).
  • The expression in thyroid follicular and papillary carcinomas were significantly lower than those of normal thyroid tissue (P < 0.05).
  • There was no difference of the expression between nodular goiter and normal thyroid tissue (P > 0.05).
  • CONCLUSIONS: Motilin peptide and its precursor mRNA are expressed in C cells of human thyroid.
  • The expressions of both motilin and its precursor mRNA in thyroid medullary carcinoma and acidophilic adenoma are significantly increased.
  • In contrast, their expressions in thyroid follicular and papillary carcinomas are significantly decreased.
  • Motilin may regulate physiological functions of the thyroid through parafollicular cells.
  • Motilin may be involved in the pathogenesis of medullary carcinoma and acidophilic adenoma of the thyroid.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Motilin / metabolism. RNA Precursors / metabolism. RNA, Messenger / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adult. Aged. Carcinoma, Medullary / genetics. Carcinoma, Papillary / genetics. Carcinoma, Papillary / metabolism. Female. Humans. Intestines / metabolism. Male. Middle Aged. Nervous System Neoplasms / metabolism. Thyroid Gland / metabolism

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  • (PMID = 18844033.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA Precursors; 0 / RNA, Messenger; 52906-92-0 / Motilin
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48. Tamiolakis D, Tsamis I, Thomaidis V, Lambropoulou M, Alexiadis G, Venizelos I, Jivanakis T, Papadopoulos N: Jaw bone metastases: four cases. Acta Dermatovenerol Alp Pannonica Adriat; 2007 Mar;16(1):21-5
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  • RESULTS: Two cases originated from the thyroid gland, one was from the esophagus, and one from the liver.
  • [MeSH-major] Adenocarcinoma / secondary. Mandibular Neoplasms / secondary. Maxillary Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Esophageal Neoplasms / pathology. Female. Humans. Liver Neoplasms / pathology. Male. Middle Aged. Retrospective Studies. Thyroid Neoplasms / pathology

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  • [RetractionIn] Papadopoulos N. Acta Dermatovenerol Alp Pannonica Adriat. 2009 Sep;18(3):143 [19784531.001]
  • (PMID = 17992450.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Retracted Publication
  • [Publication-country] Slovenia
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49. Hofman V, Lassalle S, Butori C, Guevara N, Santini J, Hofman P: [A diagnostic pitfall: papillary adenocarcinoma arising in ectopic thyroid tissue within a branchial cyst]. Ann Pathol; 2006 Jun;26(3):200-3
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  • [Title] [A diagnostic pitfall: papillary adenocarcinoma arising in ectopic thyroid tissue within a branchial cyst].
  • A case of thyroid papillary carcinoma arising in ectopic thyroid tissue within a branchial cleft cyst is described.
  • Complete dissection of the thyroid gland was necessary to rule out the differential diagnosis of primary thyroid carcinoma.
  • The thyroglossal duct tract is an unusual localization for thyroid carcinomas in ectopic thyroid tissue.
  • Thyroid carcinoma arising in ectopic thyroid tissue within a branchial cyst is extremely rare.
  • Complete thyroidectomy may be necessary to eliminate an occult thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Branchioma / pathology. Choristoma / pathology. Thyroid Gland
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Treatment Outcome

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  • (PMID = 17127850.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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50. Nishikawa A, Ikeda T, Son HY, Okazaki K, Imazawa T, Umemura T, Kimura S, Hirose M: Pronounced synergistic promotion of N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats treated with excess soybean and iodine-deficient diets. Toxicol Sci; 2005 Aug;86(2):258-63
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  • [Title] Pronounced synergistic promotion of N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats treated with excess soybean and iodine-deficient diets.
  • We have reported that excess soybean treatment and iodine deficiency synergistically interact, resulting in remarkable induction of thyroid hyperplasias in rats.
  • In the present study, modifying effects of excess soybean and iodine-deficient diets were investigated in the post-initiation phase of N-bis(2-hydroxypropyl)nitrosamine [DHPN]-initiated thyroid tumorigenesis in rats.
  • Although no thyroid proliferative lesions were found in any group, the absolute thyroid weights were significantly (p < 0.01) elevated with the 20% soybean treatment.
  • Soybean feeding to both sexes under iodine deficient but not normal conditions dramatically enhanced the development of thyroid follicular adenomas (p < 0.01) and adenocarcinomas (p < 0.05), in good agreement with decrease in thyroxine and increase in thyroid-stimulating hormone.
  • Thus co-exposure to excess soybean and iodine deficiency results in synergistic promotion of DHPN-initiated thyroid tumorigenesis in rats, of which mechanisms appear to primarily involve effects on serum hormone levels.
  • [MeSH-major] Iodine / deficiency. Nitrosamines / toxicity. Soybeans. Thyroid Gland / drug effects. Thyroid Neoplasms / chemically induced
  • [MeSH-minor] Adenocarcinoma / chemically induced. Adenocarcinoma / pathology. Adenoma / chemically induced. Adenoma / pathology. Animals. Carcinogens / toxicity. Diet. Female. Male. Rats. Rats, Inbred F344. Thyrotropin / blood. Thyroxine / blood. Triiodothyronine / blood. Tumor Burden

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  • (PMID = 15901912.001).
  • [ISSN] 1096-6080
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Nitrosamines; 06LU7C9H1V / Triiodothyronine; 53609-64-6 / diisopropanolnitrosamine; 9002-71-5 / Thyrotropin; 9679TC07X4 / Iodine; Q51BO43MG4 / Thyroxine
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51. Xue WC, Hui YZ: [Problems in the diagnosis of thyroid papillary and follicular carcinoma]. Zhonghua Bing Li Xue Za Zhi; 2007 Apr;36(4):220-3
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  • [Title] [Problems in the diagnosis of thyroid papillary and follicular carcinoma].
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Carcinoma, Papillary / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Carcinoma, Papillary, Follicular / diagnosis. Carcinoma, Papillary, Follicular / pathology. Cell Nucleus / pathology. Diagnosis, Differential. Humans. Neoplasm Invasiveness. Thyroid Gland / pathology. Thyroid Nodule / diagnosis. Thyroiditis / diagnosis

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  • (PMID = 17706110.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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52. Yalcin M, Bharali DJ, Dyskin E, Dier E, Lansing L, Mousa SS, Davis FB, Davis PJ, Mousa SA: Tetraiodothyroacetic acid and tetraiodothyroacetic acid nanoparticle effectively inhibit the growth of human follicular thyroid cell carcinoma. Thyroid; 2010 Mar;20(3):281-6
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  • [Title] Tetraiodothyroacetic acid and tetraiodothyroacetic acid nanoparticle effectively inhibit the growth of human follicular thyroid cell carcinoma.
  • BACKGROUND: Tetraiodothyroacetic acid (tetrac) is a deaminated analogue of L-thyroxine that blocks the actions of L-thyroxine and 3,5,3'-triiodo-L-thyronine at the cell surface receptor for thyroid hormone on integrin alpha v beta 3.
  • Tetrac blocks the proliferative effects of thyroid hormone on tumor cells and the proangiogenesis actions of the hormone.
  • In the absence of thyroid hormone, tetrac also blocks angiogenesis induced by various growth factors.
  • Here, the activity of tetrac and tetrac NP against follicular thyroid carcinoma (FTC)-236 cells was studied in two models:.
  • [MeSH-major] Adenocarcinoma, Follicular / drug therapy. Cell Proliferation / drug effects. Nanoparticles. Thyroid Gland / drug effects. Thyroxine / analogs & derivatives

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  • (PMID = 20187783.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] PA7UX1FFYQ / tetraiodothyroacetic acid; Q51BO43MG4 / Thyroxine
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53. Kumar A, Nadig M, Patra V, Srivastava DN, Verma K, Bal CS: Adrenal and renal metastases from follicular thyroid cancer. Br J Radiol; 2005 Nov;78(935):1038-41
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  • [Title] Adrenal and renal metastases from follicular thyroid cancer.
  • Patients with differentiated thyroid cancer may have asymptomatic involvement of renal and/or adrenal gland, particularly if they are elderly and have associated metastases to other organs, which may remain undetected if these patients are not subjected to radioiodine treatment.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Adrenal Gland Neoplasms / secondary. Kidney Neoplasms / secondary. Thyroid Neoplasms / surgery


54. Hoffmann S, Wunderlich A, Lingelbach S, Musholt PB, Musholt TJ, von Wasielewski R, Zielke A: Expression and secretion of endostatin in thyroid cancer. Ann Surg Oncol; 2008 Dec;15(12):3601-8
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  • [Title] Expression and secretion of endostatin in thyroid cancer.
  • BACKGROUND: In thyroid cancer (TC) endostatin was identified as a powerful negative regulator of tumor angiogenesis in vitro.
  • METHODS: Tissue microarrays of 44 differentiated and 7 anaplastic TC and their metastasis were immunostained for endostatin protein expression and compared with corresponding non-neoplastic thyroid tissue (NT).
  • [MeSH-major] Adenocarcinoma, Follicular / metabolism. Angiogenesis Inhibitors / metabolism. Carcinoma / metabolism. Carcinoma, Papillary / metabolism. Endostatins / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism

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  • (PMID = 18818971.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Endostatins; 62229-50-9 / Epidermal Growth Factor; 9002-71-5 / Thyrotropin
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55. Ayadi L, Chaâbouni S, Dhouib H, Abbès K, Dhouib M, Makni S, Abdelmoula M, Ghorbel A, Khabir A, Boudawara T: [Polymorphous low-grade adenocarcinoma: about two cases]. Tunis Med; 2009 Jun;87(6):403-6
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  • [Title] [Polymorphous low-grade adenocarcinoma: about two cases].
  • [Transliterated title] Adénocarcinome polymorphe de bas grade: à propos de deux cas.
  • BACKGROUND: Polymorphous low-grade adenocarcinoma (APBG) is a variant of malignant tumour of minor salivary glands usually arising in the palate.
  • AIM: Our aim is to discuss morphology, evolution and differential diagnosis of this rare tumour.
  • Giving that the mass enlarged, a surgical resection carrying off the thyroid with a bilateral neck dissection was performed.
  • Diagnosis was an APBG partially resected with lymph node metastasis.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor


56. Bai XY, Shen H: [Quantitative analysis of thyroid transcription factor-1 mRNA expressions in primary lung cancer and its metastatic foci]. Nan Fang Yi Ke Da Xue Xue Bao; 2008 Jan;28(1):20-5
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  • [Title] [Quantitative analysis of thyroid transcription factor-1 mRNA expressions in primary lung cancer and its metastatic foci].
  • OBJECTIVE: To observe the expression of thyroid transcription factor-1 (TTF-1) mRNA in human normal adult type II alveolar epithelial cells, embryonic alveolar epithelial cells, and primary lung carcinoma and lymph nodes, thereby exploring the role of TTF-1 mRNA expression in the tumorigenesis, development and metastasis of lung carcinoma.
  • RESULTS: TTF-1 mRNA expression was significantly less intense in embryonic lung than in normal adult lung tissues (P= 0.000), and the two tissues both had significantly greater expression than lung adenocarcinoma, squamous cell carcinoma, small cell carcinoma and large cell carcinoma (P=0.000).
  • Lung adenocarcinoma and small cell carcinoma, with similar expression intensity (P= 0.068), showed stronger expression than squamous cell carcinoma and large cell carcinoma (P=0.000), and squamous cell carcinoma showed stronger expression than large cell carcinoma (P=0.018).
  • In lung adenocarcinoma, squamous cell carcinoma and large cell carcinoma, the intensity of TTF-1 mRNA expression was stronger in lymph node metastases than in the primary foci (P=0.003, P=0.000, P=0.019, respectively).
  • In lung carcinomas, TTF-1 mRNA expression differs between the histological types, high in lung adenocarcinoma and small cell carcinoma and rather low in squamous cell carcinoma and large cell carcinoma.
  • Strong expression of TTF-1 mRNA often indicates high likeliness of lung carcinoma metastasis, and highlights the high metastatic potentials of lung adenocarcinoma, squamous cell carcinoma and large cell carcinoma.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Female. Humans. In Situ Hybridization. Lymphatic Metastasis. Male. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Thyroid Gland / metabolism. Tissue Array Analysis / methods

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  • (PMID = 18227018.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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57. Štulík J, Kozák J, Šebesta P, Vyskočil T, Kryl J, Klezl Z: Total spondylectomy of C2: report of three cases and review of the literature. J Spinal Disord Tech; 2010 Dec;23(8):e53-8
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  • METHODS: A review of 3 patients undergoing total C2 spondylectomy for tumor (thyroid adenocarcinoma, chordoma, and solitary plasmocytoma) was done.
  • [MeSH-major] Adenocarcinoma / surgery. Axis, Cervical Vertebra / surgery. Chordoma / surgery. Orthopedic Procedures / methods. Plasmacytoma / surgery. Spinal Neoplasms / surgery

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  • (PMID = 21131798.001).
  • [ISSN] 1539-2465
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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58. Kalaitzis J, Filippou G, Zizi-Sermpetzoglou A, Marinis A, Hadjimarcou A, Paschalidis N, Rizos S: Case of a sigmoid colon cancer with metachronous metastases to the mesorectum and the abdominal wall. World J Surg Oncol; 2010;8:17
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  • BACKGROUND: Sigmoid colon cancer metachronous metastases commonly occur in the liver and lungs with sporadic reports also to the spleen, stomach, thyroid gland, abdominal wall and upper urinary tract.
  • [MeSH-major] Abdominal Neoplasms / secondary. Adenocarcinoma / secondary. Rectal Neoplasms / secondary. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Aged. Colonoscopy. Diagnosis, Differential. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 20302675.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2848135
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59. Vorburger SA, Ubersax L, Schmid SW, Balli M, Candinas D, Seiler CA: Long-term follow-up after complete resection of well-differentiated cancer confined to the thyroid gland. Ann Surg Oncol; 2009 Oct;16(10):2862-74
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  • [Title] Long-term follow-up after complete resection of well-differentiated cancer confined to the thyroid gland.
  • BACKGROUND: Papillary or follicular thyroid carcinomas exhibit a relatively benign course.
  • METHODS: Patients who underwent complete resection of well-differentiated thyroid carcinoma (WDTC) confined to the thyroid gland between 1972 and 1990 identified from a prospective database were assessed.
  • Review of histology was performed and extent of thyroid resection, postoperative therapy, and recognized prognostic factors but not lymphadenectomy were evaluated.
  • RESULTS: Of 2,867 patients, 213 had complete resection of WDTC confined to the thyroid gland.
  • Age, histology and postoperative therapy but not extent of thyroid resection determined DSS.
  • [MeSH-major] Adenocarcinoma, Follicular / surgery. Carcinoma, Papillary / surgery. Cell Differentiation. Thyroid Neoplasms / surgery. Thyroidectomy

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  • [CommentIn] Ann Surg Oncol. 2011 Feb;18(2):600 [20607419.001]
  • (PMID = 19655202.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Rubaltelli L, Corradin S, Dorigo A, Stabilito M, Tregnaghi A, Borsato S, Stramare R: Differential diagnosis of benign and malignant thyroid nodules at elastosonography. Ultraschall Med; 2009 Apr;30(2):175-9
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  • [Title] Differential diagnosis of benign and malignant thyroid nodules at elastosonography.
  • PURPOSE: Ultrasound of the neck detects a large number of non-palpable thyroid nodules in the population, but it offers poor diagnostic accuracy (the presence of microcalcifications is the only statistically significant criterion indicative of malignancy).
  • The aim of this study is to evaluate elastography, a technique which allows differentiation between pathological and normal tissue by determining its hardness and which could also prove useful in the characterisation of thyroid nodules.
  • MATERIALS AND METHODS: In this prospective study, 51 thyroid nodules in 40 consecutive patients were examined (25 women, 15 men, mean age +/- SD, 54 +/- 13.4).
  • Only in two cases ultrasound demonstrated signs useful for a differential diagnosis (intrinsic microcalcifications).
  • CONCLUSION: Elastosonography provides an interesting contribution to the differentiation of malignant and benign thyroid nodules.
  • [MeSH-major] Elasticity Imaging Techniques / methods. Image Processing, Computer-Assisted. Thyroid Neoplasms / ultrasonography. Thyroid Nodule / ultrasonography. Ultrasonography, Doppler, Color / methods
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / surgery. Adenocarcinoma, Follicular / ultrasonography. Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / surgery. Adenocarcinoma, Papillary / ultrasonography. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Calcinosis / ultrasonography. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prospective Studies. Sensitivity and Specificity. Thyroid Gland / pathology. Thyroid Gland / ultrasonography. Thyroidectomy. Ultrasonography, Interventional. Young Adult

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  • (PMID = 18496776.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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61. Adotey JM: Papillary adenocarcinoma of thyroid in a patient with right submandibular mass--a rare case of 'lateral aberrant thyroid'. Niger J Clin Pract; 2009 Sep;12(3):333-4
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  • [Title] Papillary adenocarcinoma of thyroid in a patient with right submandibular mass--a rare case of 'lateral aberrant thyroid'.
  • BACKGROUND: Ectopic thyroid is a rare entity in the study of thyroid disease.
  • The occurrence of ectopic thyroid tissue as a mass in the submandibular region is even rarer.
  • AIM: To report a case of papillary adenocarcinoma of thyroid within a right submandibular mass in a 67-year-old man.
  • The FNAB showed papillary adenocarcinoma of the thyroid.
  • CONCLUSION: This patient illustrates the even rarer case of a 'lateral aberrant thyroid' presenting as a malignant submandibular mass.
  • [MeSH-major] Adenocarcinoma / diagnosis. Choristoma / diagnosis. Submandibular Gland Diseases / diagnosis. Thyroid Gland. Thyroid Neoplasms / diagnosis

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  • (PMID = 19803039.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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62. Renshaw AA, Wang E, Wilbur D, Hughes JH, Haja J, Henry MR, College of American Pathologists Cytopathology Committee: Interobserver agreement on microfollicles in thyroid fine-needle aspirates. Arch Pathol Lab Med; 2006 Feb;130(2):148-52
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  • [Title] Interobserver agreement on microfollicles in thyroid fine-needle aspirates.
  • CONTEXT: Although microfollicles are a well-known feature of follicular neoplasms in fine-needle aspirates of the thyroid, the level of agreement about classifying groups as microfollicles is not known.
  • DESIGN: We showed 45 small groups of follicular cells each composed of fewer than 50 cells from fine-needle aspirates of the thyroid to 12 members of the College of American Pathologists Cytopathology Committee, who then classified the groups into microfollicles, macrofollicles, and indeterminate groups.
  • The criteria described here for reproducible microfollicles (<15 cells, arranged in a circle that is at least two-thirds complete, and flat) may help improve the agreement in classification of microfollicles and lead to more consistent classification of thyroid fine-needle aspirates.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Consensus. Pathology, Clinical / standards. Thyroid Gland / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 16454552.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Haas S, Gütgemann I, Wolff M, Fischer HP: Intrahepatic clear cell cholangiocarcinoma: immunohistochemical aspects in a very rare type of cholangiocarcinoma. Am J Surg Pathol; 2007 Jun;31(6):902-6
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  • A primary hepatocellular carcinoma and metastatic clear cell tumors of the kidney, gastrointestinal tract, and the thyroid gland were excluded by absence of CK20, CD10, HepPar1, and TTF1.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology

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  • (PMID = 17527078.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Keratin-7
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64. Rodier JF, Tuech JJ, Wilt M, Lindas P, Bruant-Rodier C: [A locally advanced intrathyroid metastasis of bronchial cancer]. Ann Otolaryngol Chir Cervicofac; 2008 Sep;125(4):198-203
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  • PURPOSE: To assess the characteristics, the diagnosis and the treatment of intrathyroid metastasis.
  • RESULTS: A 60-year-old woman, treated seven years before for a well-differentiated bronchial adenocarcinoma, developed enlargement of the thyroid gland.
  • Surgical management is decided taking into account the type and the kinetics of the primary tumor, the location of the thyroid metastasis, and the extension of the metastatic disease.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Bronchial Neoplasms / pathology. Thyroid Neoplasms / secondary. Thyroid Neoplasms / surgery. Thyroidectomy

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  • (PMID = 18755448.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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65. Aydin O, Yildiz L, Kefeli M, Kandemir B: CD117 expression in normal, neoplastic, inflammatory, and reactive lesions of the thyroid. Pathol Res Pract; 2008;204(6):359-65
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  • [Title] CD117 expression in normal, neoplastic, inflammatory, and reactive lesions of the thyroid.
  • The aim of this study was to investigate the expression of CD117 in normal, inflammatory, neoplastic, and reactive lesions of the thyroid.
  • Immunohistochemical CD117 positivity was detected in a wide range of neoplastic and inflammatory thyroid diseases.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Proto-Oncogene Proteins c-kit / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism. Thyroiditis / metabolism

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  • (PMID = 18337018.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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66. Ghofrani M, Sosa JA, Ocal IT, Angeletti C: Fine needle aspiration of poorly differentiated oxyphilic (Hürthle cell) thyroid carcinoma: a case report. Acta Cytol; 2006 Sep-Oct;50(5):560-2
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  • [Title] Fine needle aspiration of poorly differentiated oxyphilic (Hürthle cell) thyroid carcinoma: a case report.
  • BACKGROUND: Poorly differentiated oxyphilic (Hürthle cell) carcinomas are a more recently described variant of poorly differentiated thyroid carcinoma and are characterized by a prominent Hürthle cell component in a solid or trabecular arrangement.
  • Although the histology of these rare thyroid tumors has been reported in the literature, the cytologic features on fine needle aspiration biopsy have not been described before.
  • CASE: A 73-year-old man with a long history of radioactive iodine and levothyroxine therapy for multinodular goiter presented with a painful, rapidly expanding, 6-cm, left thyroid mass with aggressive radiologic features.
  • Subsequent thyroidectomy confirmed the malignant nature of this Hürthle cell-rich tumor, warranting a diagnosis of poorly differentiated oxyphilic (Hürthle cell) thyroid carcinoma.
  • CONCLUSION: Poorly differentiated oxyphilic thyroid carcinoma is an aggressive variant of Hürthle cell carcinomas and must enter the differential diagnosis when fine needle aspiration biopsy of a radiologically aggressive thyroid mass yields extremely hypercellular smears with a prominent Hürthle cell component.
  • [MeSH-major] Adenocarcinoma / diagnosis. Epithelial Cells / pathology. Lung Neoplasms / diagnosis. Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Diagnosis, Differential. Disease Progression. Goiter, Nodular / complications. Goiter, Nodular / drug therapy. Goiter, Nodular / radiotherapy. Humans. Iodine Radioisotopes / therapeutic use. Male. Neoplasm Invasiveness. Thyroidectomy. Thyroxine / therapeutic use

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  • (PMID = 17017447.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; Q51BO43MG4 / Thyroxine
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67. Letsas KP, Vartholomatos G, Tsepi C, Tsatsoulis A, Frangou-Lazaridis M: Fine-needle aspiration biopsy-RT-PCR expression analysis of prothymosin alpha and parathymosin in thyroid: novel proliferation markers? Neoplasma; 2007;54(1):57-62
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  • [Title] Fine-needle aspiration biopsy-RT-PCR expression analysis of prothymosin alpha and parathymosin in thyroid: novel proliferation markers?
  • Fine-needle aspiration biopsy-based cytology has become an established and reliable diagnostic preoperative test in the evaluation of thyroid nodules.
  • Genetic analysis of the aspirates by RT-PCR may contribute, in parallel to the cytology report, to a more precise diagnosis.
  • A semi-quantitative RT-PCR assay was developed to determine prothymosin alpha and parathymosin mRNA expression patterns in thyroid follicular cells obtained from the fine-needle aspiration biopsy specimens of patients diagnosed with simple nodular goitre, follicular adenoma, papillary and follicular well-differentiated carcinomas.
  • Prothymosin alpha and parathymosin mRNA levels were found significantly elevated in well-differentiated carcinomas in relation to adenomas (p<0.05) and goitres (p<0.05), an event possibly linked to the proliferation activity of thyroid follicular cells.
  • Further studies are required to establish prothymosin alpha and parathymosin as diagnostic proliferation markers in thyroid cancer, especially in cases of undetermined cellular morphology of follicular origin which reflect the most common cytohistopathological discrepancies.
  • [MeSH-major] Protein Precursors / genetics. Thymosin / analogs & derivatives. Thyroid Gland / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / pathology. Adult. Aged. Biomarkers / analysis. Biopsy, Fine-Needle / methods. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. Cell Proliferation. Diagnosis, Differential. Female. Humans. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction / methods. Thyroid Nodule / genetics. Thyroid Nodule / pathology

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  • (PMID = 17203893.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Protein Precursors; 0 / RNA, Messenger; 0 / prothymosin alpha; 61512-21-8 / Thymosin; 95328-48-6 / parathymosin alpha
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68. Jovanovic L, Delahunt B, McIver B, Eberhardt NL, Bhattacharya A, Lea R, Grebe SK: Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma. Pathology; 2010;42(6):524-33
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  • [Title] Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma.
  • AIMS: This study was undertaken to investigate the genetic factors underlying the development of multifocality and phenotypic diversity in multifocal papillary thyroid carcinoma (mPTC).
  • In five cases, genetic alterations were detected in morphologically normal thyroid epithelium.
  • The relatively high genetic disarray in multifocal PTC may underlie their ability to spread throughout the thyroid gland.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Adenocarcinoma, Papillary / pathology. Biomarkers, Tumor / genetics. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology

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  • (PMID = 20854070.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA80117
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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69. Kazemi M, Assadi M, Kazemi AA, Ghazvini LA: Primary papillary carcinoma in a thyroglossal duct cyst. Hell J Nucl Med; 2006 Jan-Apr;9(1):39-40
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  • Thyroglossal duct cysts (TDC) are the most common congenital anomalies of the thyroid gland and less than 1% of them become malignant.
  • The diagnosis is usually made postoperatively.
  • Thyroid function tests were normal as well as the thyroid scan.
  • Since our patient had no marginal invasion of the carcinoma in the surrounding tissues or lymph node metastases, we recommended the Sistrunk's surgical procedure, suppressive treatment by thyroid hormones and long term follow-up.
  • [MeSH-major] Adenocarcinoma, Papillary / complications. Adenocarcinoma, Papillary / diagnosis. Thyroglossal Cyst / diagnosis. Thyroglossal Cyst / etiology. Thyroid Neoplasms / complications. Thyroid Neoplasms / diagnosis

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  • (PMID = 16617393.001).
  • [ISSN] 1790-5427
  • [Journal-full-title] Hellenic journal of nuclear medicine
  • [ISO-abbreviation] Hell J Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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70. Hjartåker A, Langseth H, Weiderpass E: Obesity and diabetes epidemics: cancer repercussions. Adv Exp Med Biol; 2008;630:72-93
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  • There is convincing evidence of a positive association between overweight/obesity and risk for adenocarcinoma of the oesophagus and the gastric cardia, colorectal cancer, postmenopausal breast cancer, endometrial cancer and kidney cancer (renal-cell).
  • For all other cancer sites the evidence of an association between overweight/obesity and cancer is inadequate, although there are studies suggesting an increased risk of cancers of the liver, gallbladder, pancreas, thyroid gland and in lymphoid and haematopoietic tissue.

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  • (PMID = 18637486.001).
  • [ISSN] 0065-2598
  • [Journal-full-title] Advances in experimental medicine and biology
  • [ISO-abbreviation] Adv. Exp. Med. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 107
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71. Aslam R, Steward D: Surgical management of thyroid disease. Otolaryngol Clin North Am; 2010 Apr;43(2):273-83, viii
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  • [Title] Surgical management of thyroid disease.
  • The surgical management of thyroid disease and its indications continue to evolve.
  • This article describes the surgical management of various thyroid pathologies.
  • [MeSH-major] Thyroid Diseases / surgery. Thyroid Neoplasms / surgery. Thyroidectomy / methods
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / surgery. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Diagnostic Imaging. Goiter, Nodular / diagnosis. Goiter, Nodular / pathology. Goiter, Nodular / surgery. Goiter, Substernal / diagnosis. Goiter, Substernal / pathology. Goiter, Substernal / surgery. Humans. Sensitivity and Specificity. Thyroid Gland / pathology. Thyroid Nodule / diagnosis. Thyroid Nodule / pathology. Thyroid Nodule / surgery

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20510714.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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72. Gkountouvas A, Nikas M, Chatjimarkou F, Thomas D, Georgiadis P, Kaldrimidis P: Thyroid cancer in Greece. A tertiary center experience. J BUON; 2010 Oct-Dec;15(4):674-8
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  • [Title] Thyroid cancer in Greece. A tertiary center experience.
  • PURPOSE: to present the frequency and distribution of histological subtypes of primary thyroid carcinoma cases diagnosed at our Department.
  • METHODS: we retrospectively analyzed the records of all patients with primary thyroid carcinoma admitted to our Department from January 01, 2002 until December 31, 2008.
  • RESULTS: of 1,607 patients with primary thyroid carcinoma 1510 (94%) suffered from differentiated thyroid carcinoma (DTC), 71 (4%) from medullary thyroid carcinoma (MTC), 10 (< 1%) from anaplastic thyroid carcinoma (ATC), 9 (<1%) from primary thyroid non Hodgkin's lymphoma, 1 (< 1%) from primary thyroid Hodgkin's lymphoma, 1 (< 1%) from squamous cell carcinoma of the thyroid, and 6 patients (< 1%) suffered from carcinoma of ectopic thyroid tissue (1 malignant struma ovarii, 2 carcinoma in thyroglossal duct remnants, and 3 patients presented with thyroid tissue carcinoma in cervical lymph nodes).
  • CONCLUSION: differentiated thyroid carcinoma is by far the most common primary malignancy of the thyroid gland.
  • Papillary thyroid carcinomas constitute the vast majority of these neoplasms.
  • Larger studies are necessary to better understand and evaluate the clinical characteristics, behavior and prevalence of thyroid cancer in our country.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Carcinoma / pathology. Carcinoma, Medullary / pathology. Carcinoma, Squamous Cell / pathology. Hodgkin Disease / pathology. Lymphoma, Non-Hodgkin / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 21229628.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] Thyroid cancer, papillary
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73. Montone KT, Baloch ZW, LiVolsi VA: The thyroid Hürthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review. Arch Pathol Lab Med; 2008 Aug;132(8):1241-50
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  • [Title] The thyroid Hürthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review.
  • CONTEXT: Hürthle cells are eosinophilic, follicular-derived cells that are associated with a variety of nonneoplastic and neoplastic thyroid lesions.
  • The differential diagnosis of Hürthle cell lesions is quite broad.
  • OBJECTIVE: To review the pathologic conditions associated with Hürthle cells in the thyroid and to discuss pathology of thyroid lesions associated with oncocytic cytology.
  • DATA SOURCES: A variety of thyroid nonneoplastic (autoimmune thyroiditis, multinodular goiter) and neoplastic conditions (Hürthle cell adenoma, Hürthle cell carcinoma) are associated with Hürthle cell cytology.
  • In addition, there are several thyroid neoplasms that should be considered when one observes a Hürthle cell neoplasm in the thyroid (oncocytic variant of medullary carcinoma, several variants of papillary thyroid carcinoma).
  • CONCLUSIONS: Oncocytic cytology is seen in a variety of thyroid conditions that are associated with a broad differential diagnosis and care must be used for accurate diagnosis.
  • Newer molecular-based techniques may be useful for further classification of thyroid neoplasms with oncocytic pathology.
  • [MeSH-major] Oxyphil Cells / pathology. Thyroid Diseases / pathology. Thyroid Gland / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Biopsy, Needle. Diagnosis, Differential. History, 19th Century. Humans. Metaplasia. Pathology, Surgical / methods. Thyroid Neoplasms / pathology

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  • (PMID = 18684023.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 107
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74. Lei JY, Huang J: Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma. Expert Opin Med Diagn; 2008 Feb;2(2):151-9
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  • [Title] Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma.
  • Thyroid transcription factor 1 (TTF-1) is a widely used biomarker in surgical pathology.
  • Its nuclear staining is sensitive and specific for the diagnosis of primary pulmonary and thyroid adenocarcinoma as well as small cell carcinomas arising in many organs.
  • This review focuses on this issue and explores the potential application of TTF-1 cytoplasmic staining in the differential diagnosis of hepatocellular carcinoma from other primary and metastatic malignancies in the liver.

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  • (PMID = 23485135.001).
  • [ISSN] 1753-0059
  • [Journal-full-title] Expert opinion on medical diagnostics
  • [ISO-abbreviation] Expert Opin Med Diagn
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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75. Bauer JA, Frye G, Bahr A, Gieg J, Brofman P: Anti-tumor effects of nitrosylcobalamin against spontaneous tumors in dogs. Invest New Drugs; 2010 Oct;28(5):694-702
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  • (1) A 13 year-old female spayed Giant Schnauzer with inoperable thyroid carcinoma and hypercalcemia. (2) A 6 year-old male neutered Golden Retriever with a malignant peripheral nerve sheath tumor (MPNST). (3) A ten yr-old neutered male Bichon Frise with apocrine gland anal sac adenocarcinoma (AGACA). (4) A 7 year-old female spayed Labrador mix with spinal meningioma following partial surgical resection.

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  • [ErratumIn] Invest New Drugs. 2011 Oct;29(5):1122
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  • (PMID = 19557306.001).
  • [ISSN] 1573-0646
  • [Journal-full-title] Investigational new drugs
  • [ISO-abbreviation] Invest New Drugs
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA095020
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Nitroso Compounds; 0 / nitrosylcobalamin; P6YC3EG204 / Vitamin B 12
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76. Vitagliano D, Portella G, Troncone G, Francione A, Rossi C, Bruno A, Giorgini A, Coluzzi S, Nappi TC, Rothstein JL, Pasquinelli R, Chiappetta G, Terracciano D, Macchia V, Melillo RM, Fusco A, Santoro M: Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas. Oncogene; 2006 Aug 31;25(39):5467-74
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  • [Title] Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas.
  • Ras oncogenes are frequently mutated in thyroid carcinomas.
  • To verify the role played by N-ras in thyroid carcinogenesis, we generated transgenic mice in which a human N-ras(Gln61Lys) oncogene (Tg-N-ras) was expressed in the thyroid follicular cells.
  • Tg-N-ras mice developed thyroid follicular neoplasms; 11% developed follicular adenomas and approximately 40% developed invasive follicular carcinomas, in some cases with a mixed papillary/follicular morphology.
  • N-ras(Gln61Lys) expression in cultured PC Cl 3 thyrocytes induced thyroid-stimulating hormone-independent proliferation and genomic instability with micronuclei formation and centrosome amplification.
  • These findings support the notion that mutated ras oncogenes could be able to drive the formation of thyroid tumors that can progress to poorly differentiated, metastatic carcinomas.
  • [MeSH-major] Genes, ras. Thyroid Gland / pathology. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / pathology. Adenoma / genetics. Adenoma / pathology. Amino Acid Substitution. Animals. Cell Differentiation. Humans. Mice. Mice, Transgenic. Neoplasm Invasiveness


77. Lee JS, Moon W, Park SJ, Park MI, Kim KJ, Jang LL, Park MJ, Chun BK: Triple synchronous primary cancers of rectum, thyroid, and uterine cervix detected during the workup for hematochezia. Intern Med; 2010;49(16):1745-7
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  • [Title] Triple synchronous primary cancers of rectum, thyroid, and uterine cervix detected during the workup for hematochezia.
  • Herein, we report an extremely rare case of synchronous triple primary cancers of the rectum, thyroid gland and uterine cervix; all were detected during the work-up for hematochezia.
  • [MeSH-major] Gastrointestinal Hemorrhage / diagnosis. Neoplasms, Multiple Primary / diagnosis. Rectal Neoplasms / diagnosis. Thyroid Neoplasms / diagnosis. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma, Mucinous / complications. Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / diagnosis. Female. Follow-Up Studies. Humans. Middle Aged


78. Strik MW, Anders S, Barth M, Bärlehner E, Benecke C, Benhidjeb T: [Total videoendoscopic thyroid resection by the axillobilateral breast approach. Operative method and first results]. Chirurg; 2007 Dec;78(12):1139-44
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  • [Title] [Total videoendoscopic thyroid resection by the axillobilateral breast approach. Operative method and first results].
  • BACKGROUND: The axillobilateral breast approach (ABBA) is a procedure allowing thyroid resection without scarring at the neck.
  • RESULTS: Twenty-six female patients underwent thyroid resection using the ABBA technique.
  • [MeSH-major] Adenocarcinoma, Follicular / surgery. Cysts / surgery. Endoscopes. Minimally Invasive Surgical Procedures / instrumentation. Surgical Instruments. Thyroid Diseases / surgery. Thyroid Neoplasms / surgery. Thyroid Nodule / surgery. Thyroidectomy / instrumentation. Video-Assisted Surgery / instrumentation
  • [MeSH-minor] Adult. Axilla / innervation. Axilla / surgery. Biopsy, Needle. Female. Humans. Intraoperative Complications / diagnosis. Intraoperative Complications / prevention & control. Middle Aged. Monitoring, Intraoperative / instrumentation. Recurrent Laryngeal Nerve Injuries. Reoperation. Thyroid Gland / pathology. Ultrasonic Therapy / instrumentation. Vocal Cord Paralysis / diagnosis. Vocal Cord Paralysis / prevention & control

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  • (PMID = 17805497.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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79. Raggio E, Camandona M, Solerio D, Martino P, Franchello A, Orlandi F, Gasparri G: The diagnostic accuracy of the immunocytochemical markers in the pre-operative evaluation of follicular thyroid lesions. J Endocrinol Invest; 2010 Jun;33(6):378-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The diagnostic accuracy of the immunocytochemical markers in the pre-operative evaluation of follicular thyroid lesions.
  • MATERIALS AND METHODS: We retrospectively evaluated 100 patients suffering from thyroid nodular disease submitted to thyroidectomy from 2006 to 2007 in our Institution.
  • CONCLUSIONS: Based on the data from our experience, the patients with a cytological diagnosis of GAL3 positive follicular neoformation should be referred for surgery without any further immunocytological testing.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Galectin 3 / analysis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / surgery. Biomarkers / analysis. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Diagnostic Errors. Female. Gene Expression. Humans. Keratin-19 / biosynthesis. Male. Middle Aged. Predictive Value of Tests. Preoperative Care. Retrospective Studies. Sensitivity and Specificity. Thyroid Gland / chemistry. Thyroid Gland / surgery

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  • (PMID = 19625759.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / HBME-1 antigen; 0 / Keratin-19
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80. Rakheja D, Gomez AM: Thyroid enlargement, hyperthyroidism, and antibodies to thyroglobulin and thyroid peroxidase in an 11-year-old girl. Arch Pathol Lab Med; 2005 Jun;129(6):e159-61
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  • [Title] Thyroid enlargement, hyperthyroidism, and antibodies to thyroglobulin and thyroid peroxidase in an 11-year-old girl.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Iodide Peroxidase / metabolism. Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis

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  • (PMID = 15913449.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; EC 1.11.1.8 / Iodide Peroxidase; Q51BO43MG4 / Thyroxine
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81. Yousuf K, Archibald SD: Brain metastases from papillary adenocarcinoma of the thyroid. J Otolaryngol; 2006 Dec;35(6):366-72
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  • [Title] Brain metastases from papillary adenocarcinoma of the thyroid.
  • BACKGROUND: Papillary thyroid adenocarcinoma (PTA) is the most common type of thyroid malignancy.
  • We present a series of four patients with this development and review their diagnosis and treatment.
  • All patients eventually died of their disease, and the overall survival after the diagnosis of brain metastases was 15.3 months in the four patients.
  • [MeSH-major] Adenocarcinoma, Papillary / secondary. Brain Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 17380829.001).
  • [ISSN] 0381-6605
  • [Journal-full-title] The Journal of otolaryngology
  • [ISO-abbreviation] J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 9010-34-8 / Thyroglobulin
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82. Bianciotto C, Demirci H, Shields CL, Eagle RC Jr, Shields JA: Metastatic tumors to the eyelid: report of 20 cases and review of the literature. Arch Ophthalmol; 2009 Aug;127(8):999-1005
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  • RESULTS: The primary tumors included skin melanoma (4 [20%]), uveal melanoma (4 [20%]), breast carcinoma and conjunctival melanoma (3 [15%] each), renal cell carcinoma (2 [10%]), and medullary thyroid carcinoma, prostate carcinoma, lung carcinoma, and salivary gland carcinoma (1 [5%] each).
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Renal Cell / secondary. Eyelid Neoplasms / secondary. Neoplasms / pathology

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  • (PMID = 19667336.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 19
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83. Romanchishen AF, Kuz'michev AS, Bogatikov AA, Morozova EB, Chukhlovin AB, Totolian AA: [Clinical significance of functional variants of matrix metalloproteinase genes in thyroid cancer]. Vestn Khir Im I I Grek; 2009;168(1):57-60
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  • [Title] [Clinical significance of functional variants of matrix metalloproteinase genes in thyroid cancer].
  • Under analysis were results of genetic investigations of 105 patients with thyroid cancer (TC) treated from 2004 through 2007 in the St. Petersburg City Center of surgery and oncology of the endocrine system organs.
  • It was shown that MMP genes could be a substantial factor of slowing down the rate of malignant growth and invasive properties of cancer of the thyroid gland.
  • [MeSH-major] Adenocarcinoma, Papillary / enzymology. DNA, Neoplasm / genetics. Gene Expression Regulation, Neoplastic. Genetic Variation. Matrix Metalloproteinase 1 / genetics. Matrix Metalloproteinase 3 / genetics. Thyroid Neoplasms / enzymology

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  • (PMID = 19432148.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 3.4.24.17 / Matrix Metalloproteinase 3; EC 3.4.24.7 / Matrix Metalloproteinase 1
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84. Kaya H, Barbaros U, Erbil Y, Bozbora A, Kapran Y, Aral F, Ozarmağan S: Metastatic thyroid carcinoma. N Z Med J; 2005 Oct 28;118(1224):U1705
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  • [Title] Metastatic thyroid carcinoma.
  • Although metastases to the thyroid gland are common in autopsy studies, clinically significant metastases are rare.
  • A 58-year-old Turkish patient, presenting with thyroid metastasis 2 years after undergoing left nephrectomy for renal cell carcinoma, is reported in this case report.
  • Thyroid metastasis can be the initial presentation of renal cell carcinoma, or it may occur a long time after nephrectomy, which can lead to misdiagnosis of primary thyroid neoplasm.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Thyroid Neoplasms / secondary

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  • [CommentIn] N Z Med J. 2006;119(1235):U2013 [16751831.001]
  • (PMID = 16258580.001).
  • [ISSN] 1175-8716
  • [Journal-full-title] The New Zealand medical journal
  • [ISO-abbreviation] N. Z. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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85. Jung EJ, Moon HG, Park ST, Cho BI, Lee SM, Jeong CY, Ju YT, Jeong SH, Lee YJ, Choi SK, Ha WS, Lee JS, Kang KR, Hong SC: Decreased annexin A3 expression correlates with tumor progression in papillary thyroid cancer. Proteomics Clin Appl; 2010 May;4(5):528-37
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Decreased annexin A3 expression correlates with tumor progression in papillary thyroid cancer.
  • EXPERIMENTAL DESIGN: We performed 2-D gel electrophoresis and MALDI-TOF MS to investigate the differentially expressed proteins in 25 papillary thyroid carcinoma tissues.
  • RESULTS: Our proteomic analyses revealed significantly decreased annexin A3 expression in papillary thyroid carcinoma at both the protein and mRNA levels, compared with normal thyroid tissue.
  • ANXA3 immunoreactivity was not significantly correlated with lymph node metastasis, multifocality, capsular invasion or perithyroidal extension in thyroid cancer.
  • CONCLUSION AND CLINICAL RELEVANCE: Decreased expression of ANXA3 in papillary thyroid cancer supports the idea that ANXA3 may be an effective marker of microcarcinoma, and a negative predictor of papillary thyroid cancer progression.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. Annexin A3 / biosynthesis. Lymphatic Metastasis / physiopathology. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Electrophoresis, Gel, Two-Dimensional. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization. Thyroid Gland / metabolism

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  • [Copyright] Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
  • (PMID = 21137070.001).
  • [ISSN] 1862-8354
  • [Journal-full-title] Proteomics. Clinical applications
  • [ISO-abbreviation] Proteomics Clin Appl
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.1.4.43 / Annexin A3
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86. Rubio V, Tamarit JM, Baviera N, Fernández S, Estrems P, Seijas T, López C, Dalmau J: [Methodology for evaluation of malignancy screening in surgical thyroid gland disease]. Acta Otorrinolaringol Esp; 2009 Nov-Dec;60(6):390-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Methodology for evaluation of malignancy screening in surgical thyroid gland disease].
  • [Transliterated title] Evaluación metodológica para detección de malignidad en patología quirúrgica tiroidea.
  • INTRODUCTION: We review a methodology for detection of malignancy in thyroid gland surgery, comparing clinical exploration, ultrasonography, gammagraphy, fine-needle aspiration (FNA) and extemporaneous biopsy with the definitive pathological results.
  • MATERIAL AND METHODS: We carried out a retrospective study on a sample of 433 (N=433) patients who had been intervened due to thyroid gland disease at the same ENT centre between 1999 and 2004.
  • RESULTS: With N=433, the male/female ratio was approximately 1/9 (m/f 1/9), the average age was 45.5 years, with a range between 13 and 87 years, and with 20.3% of referred family history of thyroid gland disease; the cervical exploration, ultrasonography ang gammagraphy were not good tests for the screening of malignancy; FNA and extemporaneous biopsy offered 74% and 81% of sensitivity (Se), and 73% and 92% of specificity (Sp) in the detection of malignancy.
  • CONCLUSIONS: FNA has good sensitivity in clinical suspicion of thyroid papillary carcinoma, although it should be complemented by extemporaneous biopsy due to its better specificity.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Adenoma / diagnosis. Carcinoma, Papillary / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / radionuclide imaging. Adenoma, Oxyphilic / surgery. Adenoma, Oxyphilic / ultrasonography. Adolescent. Adult. Aged. Aged, 80 and over. Biopsy / methods. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Palpation. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Thyroid Diseases / diagnosis. Thyroid Diseases / pathology. Thyroid Diseases / radionuclide imaging. Thyroid Diseases / ultrasonography. Thyroidectomy. Young Adult

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  • (PMID = 19850274.001).
  • [ISSN] 1988-3013
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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87. Chen HW, Tseng FY, Su DH, Chang YL, Chang TC: Secondary infection and ischemic necrosis after fine needle aspiration for a painful papillary thyroid carcinoma: a case report. Acta Cytol; 2006 Mar-Apr;50(2):217-20
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  • [Title] Secondary infection and ischemic necrosis after fine needle aspiration for a painful papillary thyroid carcinoma: a case report.
  • BACKGROUND: Papillary thyroid carcinoma (PTC) is often asymptomatic and rarely presents as a painful goiter.
  • Further, the thyroid gland is not easily infected.
  • Although FNAC is feasible for studying a thyroid lesion, malignant cells might be missed when secoandary injection and ischemic necrosis occur after FNA.
  • Therefore, aseptic procedures are necessary to prevent bacteria from seeding into the thyroid.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Ischemia / pathology. Pain / etiology. Thyroid Neoplasms / diagnosis. Thyroiditis, Suppurative / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle / adverse effects. Biopsy, Fine-Needle / methods. Diagnosis, Differential. Female. Humans. Necrosis. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 16610694.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Zhang PJ, Gao HG, Pasha TL, Litzky L, Livolsi VA: TTF-1 expression in ovarian and uterine epithelial neoplasia and its potential significance, an immunohistochemical assessment with multiple monoclonal antibodies and different secondary detection systems. Int J Gynecol Pathol; 2009 Jan;28(1):10-8
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  • Thyroid transcription factor-1 (TTF-1) is a 38-kd homeodomain containing DNA-binding protein, identified in thyroid and lung as a regulator of thyroid-specific genes and surfactant and Clara cell secretory protein gene expression.
  • TTF-1 has been used as a reliable lineage marker for lung adenocarcinoma and thyroid carcinoma in surgical pathology.

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  • (PMID = 19047914.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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89. Rago T, Di Coscio G, Basolo F, Scutari M, Elisei R, Berti P, Miccoli P, Romani R, Faviana P, Pinchera A, Vitti P: Combined clinical, thyroid ultrasound and cytological features help to predict thyroid malignancy in follicular and Hupsilonrthle cell thyroid lesions: results from a series of 505 consecutive patients. Clin Endocrinol (Oxf); 2007 Jan;66(1):13-20
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  • [Title] Combined clinical, thyroid ultrasound and cytological features help to predict thyroid malignancy in follicular and Hupsilonrthle cell thyroid lesions: results from a series of 505 consecutive patients.
  • The diagnostic value of atypia at cytology, clinical parameters and echographic patterns were examined to establish the risk of malignancy in 505 patients with follicular and Hupsilonrthle cell thyroid nodules at cytology.
  • RESULTS: Histological diagnosis of malignancy was carried out in 125 of 505 (25%) patients, the follicular variant of papillary carcinoma being the most frequent histotype.
  • Male gender, normal thyroid volume, single nodularity, nodule hypoechogenicity, size and blurred margins were associated with malignancy, although not significantly.
  • CONCLUSIONS: Twenty-five per cent of patients with a cytological result of follicular and Hupsilonrthle cell thyroid lesion had a final diagnosis of malignancy.
  • Only atypia at cytology and spot microcalcifications at thyroid ultrasound were significantly associated with malignancy.
  • Other clinical parameters and thyroid ultrasound patterns can be used to set up a clinical score useful for predicting the individual risk of malignancy before surgery.
  • [MeSH-major] Thyroid Gland / pathology. Thyroid Neoplasms / pathology. Thyroid Nodule / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / ultrasonography. Adenoma / pathology. Adenoma / ultrasonography. Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / ultrasonography. Adult. Biopsy, Fine-Needle. Calcinosis / ultrasonography. Carcinoma, Medullary / pathology. Carcinoma, Medullary / ultrasonography. Carcinoma, Papillary, Follicular / pathology. Carcinoma, Papillary, Follicular / ultrasonography. Chi-Square Distribution. Cytodiagnosis. Diagnosis, Differential. Female. Humans. Hyperplasia. Male. Middle Aged. Predictive Value of Tests

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  • (PMID = 17201796.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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90. Kim JW, Park IS, Kim BM, Kim YM, Chu YC, Cho YU: The clinical significance of atypia in thyroid fine-needle aspiration. Eur Arch Otorhinolaryngol; 2007 Sep;264(9):1053-7
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  • [Title] The clinical significance of atypia in thyroid fine-needle aspiration.
  • Fine-needle aspiration cytology (FNAC) of thyroid nodules has become the primary diagnostic tool in the evaluation of thyroid nodules.
  • However, the diagnostic utility of thyroid cytology may be limited by the presence of atypical cytologic patterns.
  • The purpose of this study is to correlate subcategories of atypical cytology of thyroid gland with final histologic diagnoses, and to help develop a treatment plan for thyroid nodules.
  • We retrospectively reviewed 133 specimens of patients with atypical cytology of thyroid nodule according to preoperative FNAC.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Cell Biology. Thyroid Neoplasms / diagnosis. Thyroid Nodule / surgery
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Prevalence. Reproducibility of Results. Treatment Outcome

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  • [ISSN] 0937-4477
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  • [Language] eng
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91. Trivedi P, Jain R, Talukdar P, Patel T, Shah M: Rectal adenocarcinoma metastatic to the thyroid gland: report of a case with review of literature. J Gastrointest Cancer; 2007;38(1):34-7
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  • [Title] Rectal adenocarcinoma metastatic to the thyroid gland: report of a case with review of literature.
  • [MeSH-major] Adenocarcinoma / secondary. Rectal Neoplasms / pathology. Thyroid Neoplasms / secondary

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  • (PMID = 19065722.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Cheng SP, Yin PH, Chang YC, Lee CH, Huang SY, Chi CW: Differential roles of leptin in regulating cell migration in thyroid cancer cells. Oncol Rep; 2010 Jun;23(6):1721-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential roles of leptin in regulating cell migration in thyroid cancer cells.
  • Excess body weight is associated with a moderately increased risk of thyroid cancer.
  • Limited evidence suggests that leptin has direct actions on the thyroid gland, but there are no data available on the effect of leptin on thyroid cancer cells.
  • We evaluated the action of leptin on gene expression, cell growth, cell cycle, and cell migration in anaplastic (ARO), follicular (WRO) and papillary (CGTH-W3) thyroid carcinoma cell lines.
  • Expression of long-form leptin receptors was observed in all thyroid cancer cell lines.
  • However, leptin was able to promote cell migration of papillary thyroid cancer cells, but inhibited migration of anaplastic and follicular cancer cells.
  • In summary, our study suggests that leptin modulates cell migration of thyroid cancer cells in a cell type-specific manner.
  • [MeSH-major] Adenocarcinoma, Follicular / metabolism. Carcinoma / metabolism. Carcinoma, Papillary / metabolism. Cell Movement. Leptin / metabolism. Thyroid Neoplasms / metabolism

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  • (PMID = 20428831.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Leptin; 0 / RNA, Messenger; 0 / Receptors, Leptin
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93. Kim DS, Franklyn JA, Boelaert K, Eggo MC, Watkinson JC, McCabe CJ: Pituitary tumor transforming gene (PTTG) stimulates thyroid cell proliferation via a vascular endothelial growth factor/kinase insert domain receptor/inhibitor of DNA binding-3 autocrine pathway. J Clin Endocrinol Metab; 2006 Nov;91(11):4603-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pituitary tumor transforming gene (PTTG) stimulates thyroid cell proliferation via a vascular endothelial growth factor/kinase insert domain receptor/inhibitor of DNA binding-3 autocrine pathway.
  • OBJECTIVE: Our objective was to test whether VEGF, ID3, and KDR confer a PTTG-mediated effect on thyroid cell growth.
  • DESIGN: Gene expression, MAPK stimulation, and cell proliferation were assessed in follicular thyroid cancer FTC133 cells.
  • Gene expression and clinical associations were determined in 21 normal and 38 tumorous thyroid specimens (nine follicular and 29 papillary).
  • RESULTS: ID3 correlated with VEGF mRNA expression in our series of thyroid cancers, which also showed up-regulated KDR mRNA.
  • PTTG significantly correlated with KDR mRNA expression in our thyroid cancer cohort and up-regulated KDR and VEGF expression in FTC133 cells.
  • CONCLUSIONS: We report the presence of a VEGF/KDR/ID3-dependent autocrine pathway in FTC133 thyroid cells.
  • By up-regulating both VEGF and KDR expression, we propose a novel PTTG-mediated proliferative pathway that may be critical to thyroid cancer growth and progression.
  • [MeSH-major] Autocrine Communication. Cell Proliferation. Inhibitor of Differentiation Proteins / physiology. Neoplasm Proteins / physiology. Thyroid Gland / physiology. Vascular Endothelial Growth Factor A / physiology. Vascular Endothelial Growth Factor Receptor-2 / physiology
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Carcinoma, Papillary / metabolism. Gene Expression Regulation, Neoplastic. Growth Substances / metabolism. Humans. Mitogen-Activated Protein Kinases / metabolism. Paracrine Communication. Phosphorylation. Securin. Thyroid Neoplasms / metabolism. Tumor Cells, Cultured. Up-Regulation

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  • (PMID = 16926250.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Growth Substances; 0 / Inhibitor of Differentiation Proteins; 0 / Neoplasm Proteins; 0 / Securin; 0 / Vascular Endothelial Growth Factor A; 0 / pituitary tumor-transforming protein 1, human; 147785-34-0 / ID3 protein, human; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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94. Shulutko AM, Semikov VI, Griaznov VI, Chakvetadze NG, Popov SV: [Clinical value, diagnosis and treatment of thyroid differentiated microcarcinoma]. Khirurgiia (Mosk); 2007;(12):4-10
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  • [Title] [Clinical value, diagnosis and treatment of thyroid differentiated microcarcinoma].
  • Results of surgical treatment of 240 patients with thyroid differentiated microcarcinoma (less 1 cm in diameter) are analyzed.
  • In some cases microcarcinoma had aggressive clinical course: at 10.8% patients the tumor was extended beyond the bounds of thyroid capsule (T3), at 2.1% patients the primary symptoms of disease were metastases into cervical nodes.
  • Microcarcinoma is regarded as early stage of thyroid gland cancer.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Papillary / diagnosis. Thyroid Neoplasms / diagnosis. Thyroidectomy / methods
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Diagnosis, Differential. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Russia / epidemiology. Severity of Illness Index. Survival Rate. Time Factors

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  • (PMID = 18163106.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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95. Giovanella L, Ceriani L, Ghelfo A, Maffioli M: Circulating cytokeratin 19 fragments in patients with benign nodules and carcinomas of the thyroid gland. Int J Biol Markers; 2008 Jan-Mar;23(1):54-7
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  • [Title] Circulating cytokeratin 19 fragments in patients with benign nodules and carcinomas of the thyroid gland.
  • Cytokeratin 19 (CK19) is an acidic protein of 40 kDa that is part of the cytoskeleton of epithelial cells and is highly expressed by differentiated thyroid carcinomas, mainly of the papillary subtype.
  • The present study was planned to assess the serum expression of Cyfra 21.1 in patients with benign thyroid nodules and thyroid malignancies.
  • We enrolled 135 patients with histologically proven benign thyroid nodules (n=79) and thyroid carcinomas (n=56).
  • When thyroid malignancies were subdivided according to tumor histology, serum Cyfra 21.1 increased significantly from classical differentiated thyroid carcinomas (papillary or follicular) to less differentiated or undifferentiated carcinomas (poorly differentiated or anaplastic).
  • These pathways characterized anaplastic and poorly differentiated thyroid carcinoma but not classical forms of differentiated thyroid carcinoma.
  • Consequently, Cyfra 21.1 may be regarded as a circulating marker of poorly differentiated and anaplastic thyroid carcinoma.
  • Additionally, a role of Cyfra 21.1 as a dedifferentiation marker in patients with classical differentiated thyroid carcinomas may be postulated and should be explored by further focused studies.
  • [MeSH-major] Antigens, Neoplasm / blood. Keratin-19 / blood. Keratins / blood. Thyroid Neoplasms / blood. Thyroid Nodule / blood
  • [MeSH-minor] Adenocarcinoma, Follicular / blood. Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / pathology. Adolescent. Adult. Aged. Apoptosis. Biomarkers, Tumor / blood. Carcinoma, Papillary / blood. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Peptide Fragments / blood

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  • (PMID = 18409152.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Keratin-19; 0 / Peptide Fragments; 0 / antigen CYFRA21.1; 68238-35-7 / Keratins
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96. Baloch ZW, LiVolsi VA: Unusual tumors of the thyroid gland. Endocrinol Metab Clin North Am; 2008 Jun;37(2):297-310, vii
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  • [Title] Unusual tumors of the thyroid gland.
  • Thyroid neoplasms are classified into three major categories: epithelial, nonepithelial, and secondary.
  • Most primary epithelial tumors of thyroid are derived from follicular cells.
  • The secondary tumors represent metastatic tumors to the thyroid usually originating in lung, kidney, and breast.
  • In this article, the authors review the unusual tumors of the thyroid, their morphologic features, and clinical and prognostic implications.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / pathology. Rare Diseases / diagnosis. Rare Diseases / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Carcinoma, Papillary / pathology. Disease Progression. Humans. Neoplasm Staging. Prognosis. Thyroid Gland / pathology

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  • (PMID = 18502328.001).
  • [ISSN] 0889-8529
  • [Journal-full-title] Endocrinology and metabolism clinics of North America
  • [ISO-abbreviation] Endocrinol. Metab. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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97. D'Antonio A, Addesso M, Marsilia GM, Boscaino A: Fine needle aspiration of a metastatic mucinous tumour of the thyroid gland from ovarian adenocarcinoma: a potential pitfall in the differential diagnosis of thyroid neoplasms. Cytopathology; 2007 Aug;18(4):262-4
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  • [Title] Fine needle aspiration of a metastatic mucinous tumour of the thyroid gland from ovarian adenocarcinoma: a potential pitfall in the differential diagnosis of thyroid neoplasms.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Ovarian Neoplasms / pathology. Thyroid Neoplasms / secondary
  • [MeSH-minor] Biopsy, Fine-Needle. CA-125 Antigen / analysis. CA-125 Antigen / blood. Carcinoembryonic Antigen / analysis. Carcinoembryonic Antigen / blood. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-7 / analysis. Middle Aged. Thyroid Gland / pathology. Thyroid Gland / surgery

  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
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  • (PMID = 17635164.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / Carcinoembryonic Antigen; 0 / Keratin-7
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98. Ganguly R, Mitra S, Datta AK: Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. Indian J Pathol Microbiol; 2010 Apr-Jun;53(2):337-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland.
  • Various combinations of thyroid carcinomas have been reported including those between different cancers of follicular cell origin and those between follicular and C-cell histogenesis.
  • We report a case of composite anaplastic and papillary cancer on one thyroid lobe with a follicular carcinoma in the other lobe in a female patient aged 64 years.
  • [MeSH-major] Adenocarcinoma, Follicular / complications. Adenoma / complications. Carcinoma / complications. Carcinoma, Papillary / complications. Thyroid Gland / pathology

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  • [CommentIn] Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):434-5 [21623130.001]
  • [CommentIn] Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):414-5; author reply 415 [21623114.001]
  • (PMID = 20551551.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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99. Shamim MS, Khursheed F, Bari ME, Chisti KN, Enam SA: Follicular thyroid carcinoma presenting as solitary skull metastasis: report of two cases. J Pak Med Assoc; 2008 Oct;58(10):575-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Follicular thyroid carcinoma presenting as solitary skull metastasis: report of two cases.
  • We report two otherwise healthy patients with no prior history of thyroid cancer, who presented to us with a solitary scalp lump.
  • Histopathological examination revealed metastases from well differentiated follicular thyroid carcinoma (FTC).
  • Subsequent workup confirmed occult primary carcinoma of the thyroid gland in both patients.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Skull Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 18998315.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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100. Skarf LM, Dezube BJ, Bryan B, Berkenblit A: Ovarian carcinoma with thyroid metastases causing clinical hypothyroidism: a case report. Gynecol Oncol; 2006 Aug;102(2):394-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian carcinoma with thyroid metastases causing clinical hypothyroidism: a case report.
  • BACKGROUND: Ovarian cancer is known to metastasize to the thyroid gland.
  • Despite an incidence of ovarian metastasis to the thyroid of 3-15%, clinical hypothyroidism resulting from such metastasis has not yet been reported.
  • We present a case of metastatic ovarian cancer to the thyroid resulting in clinical hypothyroidism.
  • CASE: A 55-year-old woman with recurrent papillary adenocarcinoma of the ovary presented with fatigue, abdominal distention, lymphedema, and depression.
  • Thyroid stimulating hormone was markedly elevated, and thyroid biopsy demonstrated bilateral metastatic ovarian carcinoma.
  • CONCLUSION: Although uncommon, metastatic disease to the thyroid should be considered when evaluating a patient with advanced ovarian cancer and clinical hypothyroidism.
  • [MeSH-major] Hypothyroidism / etiology. Ovarian Neoplasms / pathology. Thyroid Neoplasms / complications. Thyroid Neoplasms / secondary






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