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Items 1 to 100 of about 324
1. Selimoglu H, Duran C, Saraydaroglu O, Guclu M, Kiyici S, Ersoy C, Eren MA, Tuncel E, Imamoglu S: Prostate cancer metastasis to thyroid gland. Tumori; 2007 May-Jun;93(3):292-5
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  • [Title] Prostate cancer metastasis to thyroid gland.
  • Metastases to the thyroid gland are rarely encountered in clinical practice.
  • Occasional reports of metastasis from prostate cancer to the thyroid gland have been documented.
  • We describe the case of a 73-year-old patient presenting with thyroid metastasis from long-standing prostate cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Thyroid Neoplasms / secondary

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  • (PMID = 17679467.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 3.4.21.77 / Prostate-Specific Antigen
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2. Rubio V, Tamarit JM, Baviera N, Fernández S, Estrems P, Seijas T, López C, Dalmau J: [Methodology for evaluation of malignancy screening in surgical thyroid gland disease]. Acta Otorrinolaringol Esp; 2009 Nov-Dec;60(6):390-5
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  • [Title] [Methodology for evaluation of malignancy screening in surgical thyroid gland disease].
  • [Transliterated title] Evaluación metodológica para detección de malignidad en patología quirúrgica tiroidea.
  • INTRODUCTION: We review a methodology for detection of malignancy in thyroid gland surgery, comparing clinical exploration, ultrasonography, gammagraphy, fine-needle aspiration (FNA) and extemporaneous biopsy with the definitive pathological results.
  • MATERIAL AND METHODS: We carried out a retrospective study on a sample of 433 (N=433) patients who had been intervened due to thyroid gland disease at the same ENT centre between 1999 and 2004.
  • RESULTS: With N=433, the male/female ratio was approximately 1/9 (m/f 1/9), the average age was 45.5 years, with a range between 13 and 87 years, and with 20.3% of referred family history of thyroid gland disease; the cervical exploration, ultrasonography ang gammagraphy were not good tests for the screening of malignancy; FNA and extemporaneous biopsy offered 74% and 81% of sensitivity (Se), and 73% and 92% of specificity (Sp) in the detection of malignancy.
  • CONCLUSIONS: FNA has good sensitivity in clinical suspicion of thyroid papillary carcinoma, although it should be complemented by extemporaneous biopsy due to its better specificity.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Adenoma / diagnosis. Carcinoma, Papillary / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / radionuclide imaging. Adenoma, Oxyphilic / surgery. Adenoma, Oxyphilic / ultrasonography. Adolescent. Adult. Aged. Aged, 80 and over. Biopsy / methods. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Palpation. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Thyroid Diseases / diagnosis. Thyroid Diseases / pathology. Thyroid Diseases / radionuclide imaging. Thyroid Diseases / ultrasonography. Thyroidectomy. Young Adult

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  • (PMID = 19850274.001).
  • [ISSN] 1988-3013
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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3. Stolf BS, Santos MM, Simao DF, Diaz JP, Cristo EB, Hirata R Jr, Curado MP, Neves EJ, Kowalski LP, Carvalho AF: Class distinction between follicular adenomas and follicular carcinomas of the thyroid gland on the basis of their signature expression. Cancer; 2006 May 1;106(9):1891-900
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  • [Title] Class distinction between follicular adenomas and follicular carcinomas of the thyroid gland on the basis of their signature expression.
  • BACKGROUND: Nodules of the thyroid gland are observed frequently in patients who undergo ultrasound studies.
  • Among thyroid tumors, the diagnosis of follicular adenocarcinomas by preoperative fine-needle aspiration biopsy is a major challenge, because it requires inspection of the entire capsule to differentiate it from adenoma.
  • [MeSH-major] Adenocarcinoma, Follicular / classification. Adenoma / classification. Thyroid Neoplasms / classification

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  • (PMID = 16565969.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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4. Ayadi L, Chaâbouni S, Dhouib H, Abbès K, Dhouib M, Makni S, Abdelmoula M, Ghorbel A, Khabir A, Boudawara T: [Polymorphous low-grade adenocarcinoma: about two cases]. Tunis Med; 2009 Jun;87(6):403-6
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  • [Title] [Polymorphous low-grade adenocarcinoma: about two cases].
  • [Transliterated title] Adénocarcinome polymorphe de bas grade: à propos de deux cas.
  • BACKGROUND: Polymorphous low-grade adenocarcinoma (APBG) is a variant of malignant tumour of minor salivary glands usually arising in the palate.
  • AIM: Our aim is to discuss morphology, evolution and differential diagnosis of this rare tumour.
  • Giving that the mass enlarged, a surgical resection carrying off the thyroid with a bilateral neck dissection was performed.
  • Diagnosis was an APBG partially resected with lymph node metastasis.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor

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  • (PMID = 19927787.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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5. Ganguly R, Mitra S, Datta AK: Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. Indian J Pathol Microbiol; 2010 Apr-Jun;53(2):337-9

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  • [Title] Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland.
  • Various combinations of thyroid carcinomas have been reported including those between different cancers of follicular cell origin and those between follicular and C-cell histogenesis.
  • We report a case of composite anaplastic and papillary cancer on one thyroid lobe with a follicular carcinoma in the other lobe in a female patient aged 64 years.
  • [MeSH-major] Adenocarcinoma, Follicular / complications. Adenoma / complications. Carcinoma / complications. Carcinoma, Papillary / complications. Thyroid Gland / pathology

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  • [CommentIn] Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):434-5 [21623130.001]
  • [CommentIn] Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):414-5; author reply 415 [21623114.001]
  • (PMID = 20551551.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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6. Youn JC, Rhee Y, Park SY, Kim WH, Kim SJ, Chung HC, Hong SW, Lim SK: Severe hypothyroidism induced by thyroid metastasis of colon adenocarcinoma: a case report and review of the literature. Endocr J; 2006 Jun;53(3):339-43
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  • [Title] Severe hypothyroidism induced by thyroid metastasis of colon adenocarcinoma: a case report and review of the literature.
  • Symptoms of hoarseness and neck swelling were already evident 4 months prior at which time tests for normal thyroid function were performed.
  • An enlarged thyroid with some calcification was noticed in the neck ultrasonography with multiple cervical lymphadenopathies.
  • Core biopsy of the thyroid gland showed invasion of poorly differentiated adenocarcinoma cells.
  • The patient was started on palliative chemotherapy with thyroid hormone replacement and gradually became euthyroid.
  • From these findings and the clinical observations, thyroid metastasis with hypothyroidism developing acutely from metastatic colon adenocarcinoma was diagnosed.
  • [MeSH-major] Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Hypothyroidism / etiology. Thyroid Neoplasms / complications. Thyroid Neoplasms / secondary
  • [MeSH-minor] Aged, 80 and over. Goiter / ultrasonography. Humans. Male. Thyroid Function Tests. Thyrotropin / blood. Thyroxine / blood

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  • (PMID = 16714841.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine
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7. Laghmari M, El-Fadl SH, Gana R, Maaqili MR, Bellakhdar F: [Late cervicodorsal metastasis of thyroid adenocarcinoma treated by anterior cervicotomy]. Neurochirurgie; 2006 Dec;52(6):537-41
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  • [Title] [Late cervicodorsal metastasis of thyroid adenocarcinoma treated by anterior cervicotomy].
  • Metastasis from a thyroid adenocarcinoma is a rare entity with high mortality.
  • The histological diagnosis was follicular adenocarcinoma.
  • The development of a vertebral metastasis from a thyroid adenocarcinoma 11 years after the treatment of the primitive cancer is rare.
  • [MeSH-major] Adenocarcinoma / pathology. Cervical Vertebrae / pathology. Spinal Neoplasms / secondary. Spinal Neoplasms / surgery. Thyroid Neoplasms / pathology

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  • (PMID = 17203903.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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8. Sanioglu S, Sokullu O, Ozgen A, Demirci D, Sargin M, Bilgen F: Unusual metastasis of the papillary thyroid adenocarcinoma. Ann Thorac Surg; 2009 Jun;87(6):1928-30
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  • [Title] Unusual metastasis of the papillary thyroid adenocarcinoma.
  • Floating thrombus in the ascending aorta is rare and its association with papillary thyroid adenocarcinoma has not been documented.
  • Although the aortic wall was macroscopically normal, histologic examination revealed metastatic papillary adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / secondary. Aorta. Neoplastic Cells, Circulating. Thyroid Neoplasms / pathology

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  • (PMID = 19463626.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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9. Adotey JM: Papillary adenocarcinoma of thyroid in a patient with right submandibular mass--a rare case of 'lateral aberrant thyroid'. Niger J Clin Pract; 2009 Sep;12(3):333-4
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  • [Title] Papillary adenocarcinoma of thyroid in a patient with right submandibular mass--a rare case of 'lateral aberrant thyroid'.
  • BACKGROUND: Ectopic thyroid is a rare entity in the study of thyroid disease.
  • The occurrence of ectopic thyroid tissue as a mass in the submandibular region is even rarer.
  • AIM: To report a case of papillary adenocarcinoma of thyroid within a right submandibular mass in a 67-year-old man.
  • The FNAB showed papillary adenocarcinoma of the thyroid.
  • CONCLUSION: This patient illustrates the even rarer case of a 'lateral aberrant thyroid' presenting as a malignant submandibular mass.
  • [MeSH-major] Adenocarcinoma / diagnosis. Choristoma / diagnosis. Submandibular Gland Diseases / diagnosis. Thyroid Gland. Thyroid Neoplasms / diagnosis

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  • (PMID = 19803039.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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10. Simpson AC, McCown JL: Systemic hypertension in a dog with a functional thyroid gland adenocarcinoma. J Am Vet Med Assoc; 2009 Dec 15;235(12):1474-9
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  • [Title] Systemic hypertension in a dog with a functional thyroid gland adenocarcinoma.
  • Palpation of the ventral cervical region revealed a fixed asymmetric mass in the area of the lobes of the thyroid gland.
  • Thyroidectomy of both lobes of the gland was performed.
  • Histologic examination revealed a bilateral, multilobulated, and encapsulated thyroid gland adenocarcinoma.
  • TREATMENT AND OUTCOME: Thyroidectomy of both lobes of the gland was performed with clinical resolution of hypertension.
  • CLINICAL RELEVANCE: This report describes concurrent hypertension in a dog with a functional thyroid gland adenocarcinoma with subsequent return of blood pressure values to within reference ranges after thyroidectomy.
  • [MeSH-major] Adenocarcinoma / veterinary. Dog Diseases / etiology. Hypertension / veterinary. Thyroid Neoplasms / veterinary

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  • (PMID = 20001784.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q51BO43MG4 / Thyroxine
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11. Hemminki K, Eng C, Chen B: Familial risks for nonmedullary thyroid cancer. J Clin Endocrinol Metab; 2005 Oct;90(10):5747-53
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  • [Title] Familial risks for nonmedullary thyroid cancer.
  • OBJECTIVE: We wanted to define familial risks for histopathology-specific nonmedullary thyroid cancers through parental and sibling probands.
  • PATIENTS: Cancer data were retrieved from the Swedish Cancer Registry from years 1958 to 2002, including 3292 patients with thyroid adenocarcinoma.
  • RESULTS: The familial risk for papillary carcinoma was 3.21 and 6.24 when a parent and a sibling, respectively, were diagnosed with thyroid cancers.
  • Thyroid adenocarcinoma was shown to be associated with melanoma and connective tissue tumors, and probably also with neurinomas (schwannomas).
  • Associations found in single comparisons with papillary thyroid cancer and other sites included right-sided colon, breast, ovarian, and kidney cancers.
  • CONCLUSIONS: The present findings were based on a limited number of cases, but they display a complex and heterogeneous pattern of familial nonmedullary thyroid cancer.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / genetics. Thyroid Neoplasms / epidemiology. Thyroid Neoplasms / genetics

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  • (PMID = 16030170.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Lei JY, Huang J: Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma. Expert Opin Med Diagn; 2008 Feb;2(2):151-9

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  • [Title] Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma.
  • Thyroid transcription factor 1 (TTF-1) is a widely used biomarker in surgical pathology.
  • Its nuclear staining is sensitive and specific for the diagnosis of primary pulmonary and thyroid adenocarcinoma as well as small cell carcinomas arising in many organs.
  • This review focuses on this issue and explores the potential application of TTF-1 cytoplasmic staining in the differential diagnosis of hepatocellular carcinoma from other primary and metastatic malignancies in the liver.

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  • (PMID = 23485135.001).
  • [ISSN] 1753-0059
  • [Journal-full-title] Expert opinion on medical diagnostics
  • [ISO-abbreviation] Expert Opin Med Diagn
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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13. McCain SL, Allender MC, Bohling M, Ramsay EC, Morandi F, Newkirk KM: Thyroid neoplasia in captive raccoons (Procyon lotor). J Zoo Wildl Med; 2010 Mar;41(1):121-7
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  • [Title] Thyroid neoplasia in captive raccoons (Procyon lotor).
  • Two adult, spayed, female raccoons were diagnosed with thyroid neoplasia.
  • One raccoon had a palpable, left-sided, nonfunctional thyroid adenocarcinoma which was treated with a thyroidectomy twice with local recurrence both times.
  • The second raccoon had nonpalpable, bilateral, functional follicular thyroid adenomatous hyperplasia and was treated with a right thyroidectomy and a partial left thyroidectomy, leaving behind the grossly normal portion of the left thyroid.
  • Thyroid pathology has been documented in raccoons in Europe, but is not reported in the United States.
  • Thyroid neoplasia in raccoons can occur as a nonfunctional adenocarcinoma, as is commonly reported in dogs, or as a functional adenoma, as is commonly reported in cats.
  • [MeSH-major] Thyroid Neoplasms / veterinary

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  • (PMID = 20722264.001).
  • [ISSN] 1042-7260
  • [Journal-full-title] Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • [ISO-abbreviation] J. Zoo Wildl. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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14. Sitić S, Mirt-Dabić M, Brcić L, Juros Z, Hutinec Z, Kruslin B: DNA ploidy in thymoma and associated multiple primary malignancies in the same patient. Acta Clin Croat; 2008 Sep;47(3):155-9
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  • Thymoma may be associated with different types of additional primary malignancies; however, colorectal adenocarcinoma and thyroid cancer appear to be most common.

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  • (PMID = 19175064.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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15. Xue LY, Zou SM, Zheng S, Xie YQ, Wen P, Liu XY, Lin DM, Lü N: [Expression of fascin and CK14 in different histological types of cancer and its differential diagnostic significance]. Zhonghua Zhong Liu Za Zhi; 2010 Nov;32(11):838-44
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  • OBJECTIVE: To investigate and analyze the expression of fascin and CK14 in multiple histological types of cancer and to explore the potential value of the two proteins as markers in diagnosis and differential diagnosis of various cancer types.
  • METHODS: Tissue microarray containing esophageal squamous cell carcinoma (SCC), lung SCC, larynx SCC, uterine cervical SCC, SCC of external genital organs, lung adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, heptocellular carcinoma, pancreatic ductal adenocarcinoma, breast infiltrating ductal carcinoma, thyroid papillary carcinoma, uterine endometrioid adenocarcinoma, ovarian serous adenocarcinoma and renal clear cell carcinoma, 30 cases each, as well as corresponding normal controls was constructed.
  • In lung adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, pancreatic ductal adenocarcinoma, breast infiltrating dutal adenocarcinoma, thyroid papillary carcinoma, uterine endometrioid adenocarcinoma, ovarian serous adenocarcinoma and renal clear cell carcinoma, the positive rates were 38.0%, 23.3%, 14.3%, 10.3%, 73.3%, 13.3%, 6.7%, 60.0%, 66.7% and 10.0%, respectively.
  • It was weak and focal in lung adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, pancreatic ductal adenocarcinoma, breast infiltrating dutal adenocarcinoma, thyroid papillary carcinoma, uterine endometrioid adenocarcinoma, ovarian serous adenocarcinoma, and renal clear cell carcinoma, with a positive rate of 13.3%, 13.3%, 20.7%, 41.4%, 46.7%, 6.7%, 40.0%, 13.3%, 20.0% and 6.7%, respectively.
  • Combination of fascin and CK14 should be a valuable marker in diagnosis and differential diagnosis of carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Carcinoma, Squamous Cell / metabolism. Carrier Proteins / metabolism. Keratin-14 / metabolism. Laryngeal Neoplasms / metabolism. Microfilament Proteins / metabolism
  • [MeSH-minor] Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Cystadenocarcinoma, Serous / metabolism. Cystadenocarcinoma, Serous / pathology. Diagnosis, Differential. Esophageal Neoplasms / metabolism. Esophageal Neoplasms / pathology. Female. Humans. Liver Neoplasms / metabolism. Liver Neoplasms / pathology. Lung Neoplasms / metabolism. Lung Neoplasms / pathology. Male. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology. Uterine Cervical Neoplasms / metabolism. Uterine Cervical Neoplasms / pathology

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  • (PMID = 21223690.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Keratin-14; 0 / Microfilament Proteins; 146808-54-0 / fascin
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16. Zhang PJ, Gao HG, Pasha TL, Litzky L, Livolsi VA: TTF-1 expression in ovarian and uterine epithelial neoplasia and its potential significance, an immunohistochemical assessment with multiple monoclonal antibodies and different secondary detection systems. Int J Gynecol Pathol; 2009 Jan;28(1):10-8
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  • Thyroid transcription factor-1 (TTF-1) is a 38-kd homeodomain containing DNA-binding protein, identified in thyroid and lung as a regulator of thyroid-specific genes and surfactant and Clara cell secretory protein gene expression.
  • TTF-1 has been used as a reliable lineage marker for lung adenocarcinoma and thyroid carcinoma in surgical pathology.

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  • (PMID = 19047914.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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17. Sakellariou VI, Mavrogenis AF, Papagelopoulos PJ: Limb salvage surgery using the intramedullary diaphyseal segmental defect fixation system. J Long Term Eff Med Implants; 2008;18(1):59-67
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  • Histological diagnosis included adamantinoma, synovial sarcoma, multiple myeloma, metastatic renal cell carcinoma, myeloid carcinoma of the thyroid gland, and adenocarcinoma of the stomach.

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  • (PMID = 19348612.001).
  • [ISSN] 1050-6934
  • [Journal-full-title] Journal of long-term effects of medical implants
  • [ISO-abbreviation] J Long Term Eff Med Implants
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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18. Niu HL, Pasha TL, Pawel BR, LiVolsi VA, Zhang PJ: Thyroid transcription factor-1 expression in normal gynecologic tissues and its potential significance. Int J Gynecol Pathol; 2009 Jul;28(4):301-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyroid transcription factor-1 expression in normal gynecologic tissues and its potential significance.
  • SUMMARY: Thyroid transcription factor-1 (TTF-1) is a 38-kd nuclear protein, and a member of the NKx2 family of homeodomain transcription factors.
  • It is highly expressed in normal and neoplastic thyroid and lung tissues, and is considered a reliable marker for lung adenocarcinoma and thyroid carcinoma.

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  • (PMID = 19483637.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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19. Dib N, Benhammou A, Meziane M, Harmouch A, Nazih N, Essakali L, Kzadri M, Sefiani S: [Papillary adenocarcinoma on ectopic thyroid tissue]. Ann Otolaryngol Chir Cervicofac; 2009 Apr;126(2):65-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Papillary adenocarcinoma on ectopic thyroid tissue].
  • OBJECTIVES: To report a case of papillary adenocarcinoma occurring on ectopic thyroid tissue in the hyoid bone region.
  • The thyroid function was normal.
  • The thyroid gland was in the normal pretracheal position.
  • The pathologic study suggested a papillary adenocarcinoma on ectopic thyroid tissue.
  • CONCLUSIONS: Papillary adenocarcinoma on ectopic thyroid is a very rare situation.
  • Its diagnosis is histological.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Choristoma / pathology. Hyoid Bone / pathology. Thyroid Gland. Tongue Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Thyroidectomy. Treatment Outcome

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  • (PMID = 19296927.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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20. Scott AW, Cummings TJ, Kirkpatrick JP, Mruthyunjaya P: Choroidal metastasis of follicular thyroid adenocarcinoma diagnosed by 25-gauge transretinal biopsy. Ann Ophthalmol (Skokie); 2008;40(2):110-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Choroidal metastasis of follicular thyroid adenocarcinoma diagnosed by 25-gauge transretinal biopsy.
  • We report a case of a patient with previously treated follicular thyroid carcinoma who presented with a symptomatic amelanotic choroidal mass with low internal reflectivity and a metastatic lytic skull lesion.
  • A 25-gauge vitrector was used to perform transretinal choroidal biopsy (TRCB), confirming the diagnosis of metastatic follicular thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Choroid Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 19013920.001).
  • [ISSN] 1530-4086
  • [Journal-full-title] Annals of ophthalmology (Skokie, Ill.)
  • [ISO-abbreviation] Ann Ophthalmol (Skokie)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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21. Nabili V, Natarajan S, Hirschovitz S, Bhuta S, Abemayor E: Collision tumor of thyroid: metastatic lung adenocarcinoma plus papillary thyroid carcinoma. Am J Otolaryngol; 2007 May-Jun;28(3):218-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collision tumor of thyroid: metastatic lung adenocarcinoma plus papillary thyroid carcinoma.
  • We present a case of a collision tumor of metastatic lung adenocarcinoma and papillary thyroid carcinoma occurring in the thyroid gland of a 63-year-old woman who presented with a multinodular central neck mass.
  • This is the first report of this unique combination of tumors occurring in the thyroid gland.
  • This case report emphasizes the role of detailed histopathologic analysis and the use of immunohistochemistry in better identifying rare thyroid neoplasms.
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Papillary / pathology. Lung Neoplasms / secondary. Neoplasms, Multiple Primary / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 17499145.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Gong W, Wang E, Da J, Tan Z, Chen W: [Misdiagnosis and mistherapy of ectopic thyroid gland]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 May;20(9):402-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Misdiagnosis and mistherapy of ectopic thyroid gland].
  • OBJECTIVE: To explore the clinic characteristic, diagnosis and treatment of ectopic thyroid gland (ETG) and avoid the misdiagnosis and mistherapy of ETG.
  • The clinical features, diagnosis and management of ETG were discussed.
  • RESULT: All of patients had a normal thyroid gland in the neck and underwent a surgical resection of neck mass.
  • Postoperative pathologic examination revealed the neck masses originated from accessory thyroid gland, of them, 1 gland enlargement, 1 adenoma and 2 adenocarcinoma.
  • CONCLUSION: The well understanding of ETG and the detailed examination before surgical treatment of neck mass, including ultrasonography, CT or MRI, radioactive isotope scanning and fine needle aspiration biopsy, are keys to adequate diagnosis and management of ETG.
  • [MeSH-major] Choristoma / diagnosis. Diagnostic Errors. Thyroglossal Cyst / diagnosis. Thyroid Gland / pathology

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  • (PMID = 16836074.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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23. Sorrentino F, Atzeni J, Romano G, Buscemi G, Romano M: [Differentiated microcarcinoma of the thyroid gland]. G Chir; 2010 Jun-Jul;31(6-7):277-8
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  • [Title] [Differentiated microcarcinoma of the thyroid gland].
  • [Transliterated title] Il microcarcinoma differenziato della tiroide.
  • BACKGROUND: The thyroid microcarcinoma is a tumor with maximum diameter of 10 mm (WHO).
  • The papillary microcarcinoma is the most common form of thyroid cancer, followed by follicular microcarcinoma.
  • The aim of our study is to assess the frequency of microcarcinoma, the association of benign thyroid disease himself and the controversial surgery.
  • The PTMC was associated with cancer in only 2 cases (papillary carcinoma and parathyroid carcinoma) in the remaining thyroid tissue was suffering from benign disease (20 goiters, 3 Hashimoto thyroiditis, a trabecular adenoma).
  • TALK: Controversial is still the type of surgery to be performed in case of differentiated thyroid microcarcinomas, as well as the indication is still debated to lymphadenectomy.
  • CONCLUSIONS: Papillary microcarcinoma of the thyroid in our series, represents 57% of all thyroid cancers.
  • Microcarcinoma and benign thyroid disease association (76.92% of cases) was high.
  • [MeSH-major] Adenocarcinoma, Follicular / surgery. Carcinoma, Papillary / surgery. Lymph Node Excision. Thyroid Neoplasms / surgery. Thyroidectomy

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  • (PMID = 20646369.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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24. Bezrukov OF, Khadzhiev OCh: [The ratio of nosological forms and surgical tactics in the treatment of the thyroid gland diseases]. Klin Khir; 2005 Feb;(2):37-9
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  • [Title] [The ratio of nosological forms and surgical tactics in the treatment of the thyroid gland diseases].
  • The dynamics of morphofunctional changes of the thyroid gland tissue was analyzed in patients with the organ diseases in 1995-2003.
  • The environment soiling causes the thyroid gland tissue dysplasia and the cancer occurrence.
  • The surgical tactics in the thyroid gland diseases was adduced.

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  • (PMID = 15903223.001).
  • [ISSN] 0023-2130
  • [Journal-full-title] Klinichna khirurhiia
  • [ISO-abbreviation] Klin Khir
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Ukraine
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25. Papi G, Corrado S, LiVolsi VA: Primary spindle cell lesions of the thyroid gland; an overview. Am J Clin Pathol; 2006 Jun;125 Suppl:S95-123
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spindle cell lesions of the thyroid gland; an overview.
  • Spindle cell lesions of the thyroid gland (T-SCL) are not encountered routinely in clinical practice or in the context of thyroid pathology.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Neoplasms, Fibrous Tissue / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 16830961.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 354
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26. D'Antonio A, Addesso M, De Dominicis G, Boscaino A, Liguori G, Nappi O: Mucinous carcinoma of thyroid gland. Report of a primary and a metastatic mucinous tumour from ovarian adenocarcinoma with immunohistochemical study and review of literature. Virchows Arch; 2007 Oct;451(4):847-51
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  • [Title] Mucinous carcinoma of thyroid gland. Report of a primary and a metastatic mucinous tumour from ovarian adenocarcinoma with immunohistochemical study and review of literature.
  • Mucinous carcinoma of the thyroid gland is an uncommon tumour that from the histological point of view, resembles mucinous carcinoma of others sites.
  • Although a mucinous appearance has sometimes been reported in association with cases of typical thyroid carcinoma, true mucinous carcinoma is exceptionally rare.
  • We describe two cases of thyroid tumours with mucinous differentiation studied with immunohistochemistry.
  • Both cases disclosed a similar histological appearance, with small nests and sheets of malignant epithelial cells associated with extensive extracellular mucin that substituted and entrapped the follicular parenchyma of the thyroid.
  • Thyroglobulin and focally thyroid transcription factor (TTF) 1 were positive in one case.
  • From these findings, we classified this tumour as primary mucinous thyroid carcinoma.
  • In this case, thyroid tumour represents the first clinical sign of an ovarian mucinous adenocarcinoma, and it has not been previously described in literature.
  • Both patients died after few months to diagnosis.
  • In conclusion, primary and secondary mucinous carcinoma are rare and unusual tumours of the thyroid gland that can be a cause of pitfall in differential diagnosis.
  • In these cases, for a correct diagnosis, a complete clinical history, restricted histological criteria and immunohistochemical panel are necessary.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / secondary. Ovarian Neoplasms / pathology. Thyroid Neoplasms / pathology. Thyroid Neoplasms / secondary
  • [MeSH-minor] CA-125 Antigen / metabolism. Carcinoembryonic Antigen / metabolism. Diagnosis, Differential. Female. Humans. Middle Aged. Nuclear Proteins / metabolism. Thyroglobulin / metabolism. Transcription Factors / metabolism

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  • [Cites] Cancer. 1985 Dec 1;56(11):2647-50 [2996743.001]
  • [Cites] Cancer. 1976 Sep;38(3):1323-5 [182353.001]
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  • (PMID = 17704943.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / Carcinoembryonic Antigen; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1; 9010-34-8 / Thyroglobulin
  • [Number-of-references] 10
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27. Wills TB, Bohn AA, Finch NP, Harris SP, Caplazi P: Thyroid follicular adenocarcinoma in a ferret. Vet Clin Pathol; 2005 Dec;34(4):405-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyroid follicular adenocarcinoma in a ferret.
  • The cytologic results were most consistent with epithelial neoplasia, likely a carcinoma; thyroid origin was considered likely based on tumor location and cell morphology.
  • At necropsy, a circumscribed, ovoid mass disrupted the right cervical musculature next to the right lobe of the thyroid gland.
  • The histopathologic diagnosis was consistent with thyroid follicular adenocarcinoma.
  • Immunochemical findings confirmed thyroglobulin production by neoplastic cells, but to a lesser extent than in normal ferret thyroid tissue.
  • To our knowledge, this is the first case of thyroid follicular adenocarcinoma to be reported in a ferret, with only 1 other case of thyroid carcinoma, a C-cell carcinoma, described previously.

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  • (PMID = 16270269.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9010-34-8 / Thyroglobulin
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28. Baloch ZW, LiVolsi VA: Unusual tumors of the thyroid gland. Endocrinol Metab Clin North Am; 2008 Jun;37(2):297-310, vii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual tumors of the thyroid gland.
  • Thyroid neoplasms are classified into three major categories: epithelial, nonepithelial, and secondary.
  • Most primary epithelial tumors of thyroid are derived from follicular cells.
  • The secondary tumors represent metastatic tumors to the thyroid usually originating in lung, kidney, and breast.
  • In this article, the authors review the unusual tumors of the thyroid, their morphologic features, and clinical and prognostic implications.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / pathology. Rare Diseases / diagnosis. Rare Diseases / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Carcinoma, Papillary / pathology. Disease Progression. Humans. Neoplasm Staging. Prognosis. Thyroid Gland / pathology

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  • (PMID = 18502328.001).
  • [ISSN] 0889-8529
  • [Journal-full-title] Endocrinology and metabolism clinics of North America
  • [ISO-abbreviation] Endocrinol. Metab. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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29. Reschini E, Ferrari C, Castellani M, Matheoud R, Paracchi A, Marotta G, Gerundini P: The trapping-only nodules of the thyroid gland: prevalence study. Thyroid; 2006 Aug;16(8):757-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The trapping-only nodules of the thyroid gland: prevalence study.
  • The aim of this study was to determine the prevalence of trapping-only nodules of the thyroid gland.
  • The study was prospectively performed in patients bearing hot or warm thyroid nodules at pertechnetate scan in the presence of circulating thyrotropin (TSH) within the normal range.
  • Five had benign thyroid nodules, one follicular carcinoma, and one extrathyroid metastases of papillary-follicular carcinoma.
  • Despite controversy on this issue, trapping-only nodules of thyroid should be searched because they have risk of malignancy and must be differentiated from autonomous adenomas at the compensated stage.
  • [MeSH-major] Adenocarcinoma, Follicular / radionuclide imaging. Carcinoma / radionuclide imaging. Thyroid Neoplasms / radionuclide imaging. Thyroid Nodule / epidemiology. Thyroid Nodule / therapy. Thyrotropin / blood

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  • (PMID = 16910877.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals; 9002-71-5 / Thyrotropin; A0730CX801 / Sodium Pertechnetate Tc 99m
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30. Liu Z, Bai Y, Li Y, Ohba K, Nakamura H, Ozaki T, Taniguchi E, Mori I, Kakudo K: Non-solid type thyroid carcinoma: a case report of moderately differentiated adenocarcinoma of the thyroid. Pathol Int; 2010 Jul;60(7):524-7
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  • [Title] Non-solid type thyroid carcinoma: a case report of moderately differentiated adenocarcinoma of the thyroid.
  • We report the case of a common type papillary thyroid carcinoma (PTC) patient who developed early recurrence and persistent disease even after ablation therapy.
  • The patient was an 80-year-old man that was incidentally found to have a mass lesion in the left lower lobe of his thyroid.
  • We recently proposed a new classification for follicular cell tumors of the thyroid gland, and this case is an example of moderately-differentiated adenocarcinoma according to our classification.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 20594275.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Iodine Radioisotopes
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31. Enomoto K, Sakurai K, Amano S, Shiono M: [A case of malignant lymphoma that seemed to be thyroid cancer lymph nodes recurrence]. Gan To Kagaku Ryoho; 2008 Nov;35(12):2213-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of malignant lymphoma that seemed to be thyroid cancer lymph nodes recurrence].
  • After thyroid cancer was resected, we quite often tend to think of cervical lymphadenopathy when metastases to lymph nodes were confirmed.
  • We report our experience with a case of malignant lymphoma when we thought it to be for thyroid carcinoma recurrence cervical part metastases to lymph nodes.
  • Right lobe resection and lymphadenectomy were done to the patient with thyroid carcinoma in 1994.
  • A tumor in the survival thyroid gland was confirmed in 1995.
  • In February 2007, the tumor of the survival thyroid gland was enlarged.
  • We concluded it to be thyroid carcinoma recurrent cervical metastases to lymph nodes and performed a survival total thyroietectomy and a cervical part lymphadetectomy.
  • Histopathology diagnosis showed it to be of a papillary adenocarcinoma of thyroid recurrence.
  • However, there was no metastasis image of the thyroid carcinoma at the cervical lymph node.
  • The diagnosis was malignant lymphoma.
  • CONCLUSION: As abrupt cervical lymphadenopathy was confirmed in the thyroid recurrence case, it is important to think of lymphatic disorder instead of metastasis of thyroid cancer.
  • [MeSH-major] Lymphoma / complications. Lymphoma / pathology. Neoplasm Recurrence, Local / complications. Neoplasm Recurrence, Local / pathology. Thyroid Neoplasms / complications. Thyroid Neoplasms / pathology

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  • (PMID = 19106574.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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32. Takeyama H, Tabei I, Uchida K, Morikawa T: Sentinel node biopsy for follicular tumours of the thyroid gland. Br J Surg; 2009 May;96(5):490-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sentinel node biopsy for follicular tumours of the thyroid gland.
  • BACKGROUND: It is difficult to differentiate histologically between benign and malignant follicular-type tumours of the thyroid gland.
  • The present study evaluated whether sentinel lymph node (SLN) biopsy was helpful in obtaining the correct diagnosis of malignant follicular-type tumours, as metastasis to the lymph nodes is sufficient evidence for a diagnosis of cancer.
  • METHODS: SLN biopsy was performed for 37 follicular-type tumours suspected to be malignant on the basis of preoperative examinations, but for which the diagnosis had not been confirmed.
  • CONCLUSION: Detection of SLN metastasis was helpful in diagnosing follicular thyroid cancer and thus enabling one-stage surgery.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Sentinel Lymph Node Biopsy / methods. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Body Mass Index. Diagnosis, Differential. Female. Humans. Intraoperative Care. Length of Stay. Lymphatic Metastasis / pathology. Male. Middle Aged. Treatment Outcome

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  • [Copyright] British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 19358183.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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33. Nelson KK, Gattuso P, Xu X, Prinz RA: Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. Surgery; 2010 Oct;148(4):654-60; discussion 660
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy.
  • The Sonic Hedgehog pathway is required for normal thyroid gland development, but when activated as a result of gene mutation or overexpression, it may stimulate thyroid tumor cell proliferation.
  • This study determines whether 3 molecules, Patched, Smoothened, and Sonic Hedgehog, involved in the Sonic Hedgehog pathway are overexpressed equally in synchronous follicular thyroid adenoma and papillary thyroid carcinoma.
  • METHODS: Eighteen patients with synchronous follicular thyroid adenoma and papillary thyroid carcinoma underwent thyroidectomy.
  • CONCLUSION: Expression of the 3 molecules involved in the Sonic Hedgehog pathway was similar in follicular thyroid adenoma, but Sonic Hedgehog expression was a more sensitive indicator of malignancy in papillary thyroid carcinoma.
  • Greater understanding of the Sonic Hedgehog pathway may provide molecular methods for preventing or treating papillary thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. Adenoma / metabolism. Hedgehog Proteins / biosynthesis. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasms, Multiple Primary. Predictive Value of Tests. Thyroid Gland / metabolism. Young Adult

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20797751.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / SHH protein, human
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34. Hanna WC, Ponsky TA, Trachiotis GD, Knoll SM: Colon cancer metastatic to the lung and the thyroid gland. Arch Surg; 2006 Jan;141(1):93-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colon cancer metastatic to the lung and the thyroid gland.
  • The clinical diagnosis of primary thyroid cancer is uncommon, constituting 1.5% of all cancers in the United States.
  • Clinically diagnosed metastatic cancer to the thyroid gland is rare.
  • Colon cancer is one of the most common cancers in the United States, with a high propensity to metastasize; 30% to 40% of patients have metastatic disease at the initial diagnosis.
  • Colon cancer metastasis to the thyroid gland is rare, with only a few reported cases, mainly in the pathology literature.
  • These cases describe metastasis from colon cancer to the thyroid gland that became apparent years after the initial diagnosis of colon cancer and were usually associated with dissemination to the liver, the lung, or both.
  • We report a case of colonic adenocarcinoma metastatic to the thyroid gland and lung without involvement of the liver.
  • [MeSH-major] Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Lung Neoplasms / secondary. Thyroid Neoplasms / secondary


35. Elliott DD, Sellin R, Egger JF, Medeiros LJ: Langerhans cell histiocytosis presenting as a thyroid gland mass. Ann Diagn Pathol; 2005 Oct;9(5):267-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Langerhans cell histiocytosis presenting as a thyroid gland mass.
  • We report 2 cases of Langerhans cell histiocytosis (LCH) presenting as a thyroid mass.
  • The first case is a 45-year-old woman with a 13-year history of diabetes insipidus who presented with an enlarging thyroid mass with substernal extension.
  • The second case is a 29-year-old man who presented with an enlarging thyroid mass and skin lesions.
  • Histologic evaluation of the thyroid gland in both cases revealed extensive involvement by LCH, confirmed by immunohistochemical analysis showing Langerhans cells that were positive for CD1a and S-100 protein.
  • Langerhans cell histiocytosis can rarely involve the thyroid gland in adults, and we have identified 30 cases reported in literature.
  • Most patients had evidence of LCH involving other anatomic sites, as was true in these 2 cases, and the diagnosis was initially established by examination of other sites in a subset of patients.
  • Thyroid gland involvement as the initial presentation of LCH is a rare phenomenon that can result in misdiagnosis.
  • [MeSH-major] Histiocytosis, Langerhans-Cell / pathology. Thyroid Diseases / pathology
  • [MeSH-minor] Adenocarcinoma, Papillary / pathology. Adenoma / pathology. Adult. Diabetes Insipidus / complications. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged


36. Vorburger SA, Ubersax L, Schmid SW, Balli M, Candinas D, Seiler CA: Long-term follow-up after complete resection of well-differentiated cancer confined to the thyroid gland. Ann Surg Oncol; 2009 Oct;16(10):2862-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term follow-up after complete resection of well-differentiated cancer confined to the thyroid gland.
  • BACKGROUND: Papillary or follicular thyroid carcinomas exhibit a relatively benign course.
  • METHODS: Patients who underwent complete resection of well-differentiated thyroid carcinoma (WDTC) confined to the thyroid gland between 1972 and 1990 identified from a prospective database were assessed.
  • Review of histology was performed and extent of thyroid resection, postoperative therapy, and recognized prognostic factors but not lymphadenectomy were evaluated.
  • RESULTS: Of 2,867 patients, 213 had complete resection of WDTC confined to the thyroid gland.
  • Age, histology and postoperative therapy but not extent of thyroid resection determined DSS.
  • [MeSH-major] Adenocarcinoma, Follicular / surgery. Carcinoma, Papillary / surgery. Cell Differentiation. Thyroid Neoplasms / surgery. Thyroidectomy

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  • [CommentIn] Ann Surg Oncol. 2011 Feb;18(2):600 [20607419.001]
  • (PMID = 19655202.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Kopeć-Medrek M, Kotulska A, Zycińska-Debska E, Widuchowska M, Kucharz EJ: Exacerbated course of atrophoderma of Pasini and Pierini in patient with papillary cancer of the thyroid gland. Wiad Lek; 2010;63(1):24-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Exacerbated course of atrophoderma of Pasini and Pierini in patient with papillary cancer of the thyroid gland.
  • Atrophoderma of Pasini and Pierini is a benign cutaneous atrophy skin to morphea en plaques on repression and is considered as systemic sclerosis-like disorder.
  • Papillary cancer of the thyroid gland was diagnosed and acceleration of atrophoderma should be considered as paraneoplastic syndrome.
  • [MeSH-major] Adenocarcinoma, Papillary / complications. Skin Diseases / etiology. Skin Diseases / pathology. Thyroid Neoplasms / complications


38. Romanchishen AF, Iakovlev PN: [Special surgical treatment of patients with nodular tumors of the thyroid gland against the background of diffuse toxic goiter]. Vestn Khir Im I I Grek; 2005;164(1):21-4
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  • [Title] [Special surgical treatment of patients with nodular tumors of the thyroid gland against the background of diffuse toxic goiter].
  • It was shown that the presence of nodules in the thyroid gland did not influence the nearest and distant results when using the corresponding surgical strategy.
  • [MeSH-major] Adenocarcinoma, Follicular / surgery. Adenoma / surgery. Carcinoma, Papillary / surgery. Graves Disease / complications. Thyroid Neoplasms / surgery
  • [MeSH-minor] Adult. Age Factors. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postoperative Complications. Sex Factors. Thyroid Gland / pathology. Thyroidectomy. Time Factors. Treatment Outcome

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  • (PMID = 15957803.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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39. Cheung WY, Brierley J, Mackay HJ: Treatment of rectal cancer metastases to the thyroid gland: report of two cases. Clin Colorectal Cancer; 2008 Jul;7(4):280-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of rectal cancer metastases to the thyroid gland: report of two cases.
  • Rectal cancer rarely metastasizes to the thyroid gland.
  • When it does, however, it poses particular problems with regard to diagnosis and management.
  • Despite the use of these treatment modalities, the presence of thyroid metastasis is associated with a very poor prognosis and significant morbidity.
  • Herein, we review the literature and report on 2 cases of rectal carcinoma metastatic to the thyroid gland that were treated with oxaliplatin-containing chemotherapy regimens.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Rectal Neoplasms / pathology. Thyroid Neoplasms / secondary. Thyroid Neoplasms / therapy

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  • (PMID = 18650197.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin
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40. Sillings CN, Weathers DR, Delgaudio JM: Thyroid-like papillary adenocarcinoma of the nasopharynx: a case report in a 19-year-old male. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Sep;110(3):e25-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyroid-like papillary adenocarcinoma of the nasopharynx: a case report in a 19-year-old male.
  • Primary thyroid-like papillary adenocarcinomas of the nasopharynx are rare, with only a limited number of cases reported in the literature.
  • In this article, we describe the case of a thyroid-like papillary adenocarcinoma of the nasopharynx in a 19-year-old male, with emphasis on clinical findings, histologic and immunohistochemical characteristics, and prognosis.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Nasopharyngeal Neoplasms / pathology
  • [MeSH-minor] Carcinoma. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Thyroid Gland / pathology. Thyroid Neoplasms / pathology. Treatment Outcome. Young Adult

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20727493.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] Thyroid cancer, papillary
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41. Kumamoto K, Utsumi Y, Sugano K, Hoshino M, Suzuki S, Takenoshita S: Colon carcinoma metastasis to the thyroid gland: report of a case with a review of the literature. Tumori; 2006 May-Jun;92(3):252-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colon carcinoma metastasis to the thyroid gland: report of a case with a review of the literature.
  • Metastasis of colon cancer to the thyroid gland is very rare and we would like to report a case we have experienced, with a review of the literature.
  • Fine-needle aspiration cytology indicated adenocarcinoma with characteristic tall columnar cells, confirming our suspicion that metastasis from the ascending colon cancer had already occurred.
  • On August 13, resection of the left lobe of the thyroid gland and dissection of the cervical lymph nodes were performed.
  • Histopathology showed metastasis of the ascending colon cancer to the thyroid and lymph nodes.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / secondary

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  • [CommentIn] Tumori. 2006 Sep-Oct;92(5):465-6 [17168447.001]
  • (PMID = 16869247.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 19
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42. Andea AA, Klimstra DS: Adenocarcinoma arising in a tailgut cyst with prominent meningothelial proliferation and thyroid tissue: case report and review of the literature. Virchows Arch; 2005 Mar;446(3):316-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma arising in a tailgut cyst with prominent meningothelial proliferation and thyroid tissue: case report and review of the literature.
  • In this study, we report the clinicopathological characteristics of an adenocarcinoma developing in an unusual tailgut cyst.
  • Microscopic examination revealed a mucinous adenocarcinoma with intestinal features arising in a tailgut cyst.
  • In addition to the usual components previously described in this lesion (cuboidal, columnar, ciliated or squamous epithelial lining with scattered smooth muscle fibers in the wall), our case was unique in that it was associated with a meningothelial proliferation and benign thyroid tissue with oncocytic changes.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Choristoma / pathology. Hamartoma / complications. Sacrococcygeal Region / pathology. Thyroid Gland
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 15731926.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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43. Giovanella L, Ceriani L, Ghelfo A, Maffioli M: Circulating cytokeratin 19 fragments in patients with benign nodules and carcinomas of the thyroid gland. Int J Biol Markers; 2008 Jan-Mar;23(1):54-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Circulating cytokeratin 19 fragments in patients with benign nodules and carcinomas of the thyroid gland.
  • Cytokeratin 19 (CK19) is an acidic protein of 40 kDa that is part of the cytoskeleton of epithelial cells and is highly expressed by differentiated thyroid carcinomas, mainly of the papillary subtype.
  • The present study was planned to assess the serum expression of Cyfra 21.1 in patients with benign thyroid nodules and thyroid malignancies.
  • We enrolled 135 patients with histologically proven benign thyroid nodules (n=79) and thyroid carcinomas (n=56).
  • When thyroid malignancies were subdivided according to tumor histology, serum Cyfra 21.1 increased significantly from classical differentiated thyroid carcinomas (papillary or follicular) to less differentiated or undifferentiated carcinomas (poorly differentiated or anaplastic).
  • These pathways characterized anaplastic and poorly differentiated thyroid carcinoma but not classical forms of differentiated thyroid carcinoma.
  • Consequently, Cyfra 21.1 may be regarded as a circulating marker of poorly differentiated and anaplastic thyroid carcinoma.
  • Additionally, a role of Cyfra 21.1 as a dedifferentiation marker in patients with classical differentiated thyroid carcinomas may be postulated and should be explored by further focused studies.
  • [MeSH-major] Antigens, Neoplasm / blood. Keratin-19 / blood. Keratins / blood. Thyroid Neoplasms / blood. Thyroid Nodule / blood
  • [MeSH-minor] Adenocarcinoma, Follicular / blood. Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / pathology. Adolescent. Adult. Aged. Apoptosis. Biomarkers, Tumor / blood. Carcinoma, Papillary / blood. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Peptide Fragments / blood

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  • (PMID = 18409152.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Keratin-19; 0 / Peptide Fragments; 0 / antigen CYFRA21.1; 68238-35-7 / Keratins
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44. Temmim L, Ebraheem AK, Baker H, Sinowatz F: Cyclin D1 protein expression in human thyroid gland and thyroid cancer. Anat Histol Embryol; 2006 Apr;35(2):125-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclin D1 protein expression in human thyroid gland and thyroid cancer.
  • The role of Cyclin D1 in malignant progression of papillary carcinomas of the thyroid has yet to be established.
  • We therefore studied the expression of Cyclin D1 protein in thyroid carcinomas of young Kuwaiti patients (36 cases of conventional papillary thyroid carcinoma, 12 cases of its follicular variant, one case of tall cell thyroid carcinoma and one case of medullary carcinoma) using immunohistochemistry.
  • [MeSH-major] Carcinoma, Papillary / metabolism. Cyclin D1 / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Adolescent. Adult. Child. Child, Preschool. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male

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  • (PMID = 16542178.001).
  • [ISSN] 0340-2096
  • [Journal-full-title] Anatomia, histologia, embryologia
  • [ISO-abbreviation] Anat Histol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 136601-57-5 / Cyclin D1
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45. Buła G, Waler J, Niemiec A, Koziołek H, Bichalski W, Gawrychowski J: Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy. Endokrynol Pol; 2010 Sep-Oct;61(5):427-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy.
  • INTRODUCTION: Malignant metastases are rarely found in the thyroid gland, the incidence reaching approximately 2% of all thyroid malignant neoplasms.
  • The aim of the study was to evaluate the usefulness of fine needle aspiration biopsy (FNA) for diagnosing tumour metastases to thyroid glands.
  • Malignant metastases to the thyroid gland were detected in 10 patients, namely 2 men and 8 women aged 48-89 years.
  • The group made up 1.4% of all patients operated for malignant thyroid tumour.
  • Preoperative diagnostic procedure consisted of thyroid scintigraphy, thyroid ultrasonography, and cytology of the material obtained through FNA.
  • In addition, the hormonal activity of the thyroid gland was examined.
  • RESULTS: Among 7 patients with thyroid metastases from renal clear cell carcinoma, as diagnosed postoperatively, cytology of the thyroid material obtained through FNA revealed follicular tumour in 3 (43%) patients, tumour cells in 2 (28.5%) and atypical cells in the other 2 (28.5%).
  • Intraoperative histopathology confirmed the presence of metastasis from renal clear cell carcinoma (1) and indicated thyroid medullary cancer (1), follicular tumour (4), or trabecular adenoma with necrosis (1).
  • Among two patients with thyroid metastases from breast cancer, cytology confirmed a metastasis from breast cancer in one (the woman was disqualified for surgical treatment) and indicated follicular tumour in one.
  • Intraoperative histopathology suggested thyroid anaplastic cancer.
  • Examination of biopsy specimen revealed epithelial cells accompanied by cell atypia in one patient with thyroid metastasis from lung cancer.
  • CONCLUSIONS: Follicular tumour diagnosed by fine needle aspiration biopsy in patients after treatment for other cancers, especially renal clear cell carcinoma, should alert the surgeon to the possibility that it could be a metastasis of this cancer to the thyroid gland.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / secondary. Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / secondary. Thyroid Neoplasms / pathology. Thyroid Neoplasms / secondary

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  • (PMID = 21049452.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] Thyroid cancer, medullary
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46. Hofman V, Lassalle S, Butori C, Guevara N, Santini J, Hofman P: [A diagnostic pitfall: papillary adenocarcinoma arising in ectopic thyroid tissue within a branchial cyst]. Ann Pathol; 2006 Jun;26(3):200-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A diagnostic pitfall: papillary adenocarcinoma arising in ectopic thyroid tissue within a branchial cyst].
  • A case of thyroid papillary carcinoma arising in ectopic thyroid tissue within a branchial cleft cyst is described.
  • Complete dissection of the thyroid gland was necessary to rule out the differential diagnosis of primary thyroid carcinoma.
  • The thyroglossal duct tract is an unusual localization for thyroid carcinomas in ectopic thyroid tissue.
  • Thyroid carcinoma arising in ectopic thyroid tissue within a branchial cyst is extremely rare.
  • Complete thyroidectomy may be necessary to eliminate an occult thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Branchioma / pathology. Choristoma / pathology. Thyroid Gland
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Treatment Outcome

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  • (PMID = 17127850.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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47. Gu M, Ghafari Z: Follicular neoplasm of the thyroid gland: unique cytologic appearances in a fine-needle aspiration biopsy. Diagn Cytopathol; 2010 Sep;38(9):660-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Follicular neoplasm of the thyroid gland: unique cytologic appearances in a fine-needle aspiration biopsy.
  • Fine-needle aspiration (FNA) biopsy has become a standard first-line diagnostic procedure for palpable and nonpalpable nodules of the thyroid gland.
  • [MeSH-major] Thyroid Gland / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular. Biopsy, Fine-Needle. Humans. Male. Middle Aged. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery

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  • [Copyright] Copyright 2009 Wiley-Liss, Inc.
  • (PMID = 19950399.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Yasuda M, Ogane N, Hayashi H, Kameda Y, Miyagi Y, Iida T, Mori Y, Tsukinoki K, Minematsu T, Osamura Y: Glucose transporter-1 expression in the thyroid gland: clinicopathological significance for papillary carcinoma. Oncol Rep; 2005 Dec;14(6):1499-504

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Glucose transporter-1 expression in the thyroid gland: clinicopathological significance for papillary carcinoma.
  • Glucose transporter-1 (GLUT-1) expression was immunohistochemically analysed in a total of 268 cases of thyroid gland disease, including 129 cases of papillary carcinoma (PC), 60 cases of follicular carcinoma (FC), 57 cases of follicular adenoma, and 22 cases of adenomatous goitre.
  • [MeSH-major] Glucose Transporter Type 1 / genetics. Thyroid Gland / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Adenoma / metabolism. Adenoma / pathology. Blotting, Western. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Carcinoma, Papillary / secondary. Gene Expression. Humans. Immunohistochemistry. Lymphatic Metastasis. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Thyroid Neoplasms / metabolism. Thyroid Neoplasms / pathology

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  • (PMID = 16273245.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Glucose Transporter Type 1; 0 / RNA, Messenger
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49. Schmid KW, Ting S, Sheu SY: [Familial thyroid carcinomas]. Pathologe; 2010 Oct;31(6):485-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Familial thyroid carcinomas].
  • [Transliterated title] Familiäre Karzinome der Schilddrüse.
  • Approximately 5% of differentiated thyroid carcinomas with follicular cell differentiation, papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) and 25-30% of medullary thyroid carcinoma (MTC) are hereditary.
  • They occur either as part of a defined syndrome or are confined to the thyroid gland.
  • Compared to their sporadic non-hereditary counterparts hereditary thyroid carcinomas generally develop earlier and regularly show multifocal tumour growth.
  • With the exception of familial MTC, which is preceded by neoplastic C cell hyperplasia, no precursor lesions of hereditary thyroid carcinoma are known.
  • According to current knowledge prophylactic thyroidectomy of all other types of hereditary thyroid carcinoma is not justified.
  • [MeSH-major] Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular. Carcinoma. Carney Complex / genetics. Carney Complex / pathology. Gardner Syndrome / genetics. Gardner Syndrome / pathology. Genes, Dominant. Genes, Recessive. Germ-Line Mutation. Hamartoma Syndrome, Multiple / genetics. Hamartoma Syndrome, Multiple / pathology. Humans. Neoplasm Invasiveness / prevention & control. Syndrome. Thyroidectomy

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  • [Cites] Endocr Pathol. 2001 Summer;12(2):97-112 [11579685.001]
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  • (PMID = 20852865.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] Thyroid cancer, papillary
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50. Renshaw AA, Wang E, Wilbur D, Hughes JH, Haja J, Henry MR, College of American Pathologists Cytopathology Committee: Interobserver agreement on microfollicles in thyroid fine-needle aspirates. Arch Pathol Lab Med; 2006 Feb;130(2):148-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interobserver agreement on microfollicles in thyroid fine-needle aspirates.
  • CONTEXT: Although microfollicles are a well-known feature of follicular neoplasms in fine-needle aspirates of the thyroid, the level of agreement about classifying groups as microfollicles is not known.
  • DESIGN: We showed 45 small groups of follicular cells each composed of fewer than 50 cells from fine-needle aspirates of the thyroid to 12 members of the College of American Pathologists Cytopathology Committee, who then classified the groups into microfollicles, macrofollicles, and indeterminate groups.
  • The criteria described here for reproducible microfollicles (<15 cells, arranged in a circle that is at least two-thirds complete, and flat) may help improve the agreement in classification of microfollicles and lead to more consistent classification of thyroid fine-needle aspirates.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Consensus. Pathology, Clinical / standards. Thyroid Gland / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 16454552.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Tseleni-Balafouta S, Gakiopoulou H, Fanourakis G, Voutsinas G, Litsiou H, Sozopoulos E, Balafoutas D, Patsouris E: Fibrillin expression and localization in various types of carcinomas of the thyroid gland. Mod Pathol; 2006 May;19(5):695-700
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  • [Title] Fibrillin expression and localization in various types of carcinomas of the thyroid gland.
  • The aim of this study was to investigate fibrillin-1 expression in thyroid carcinomas at mRNA and protein level, since ECM proteins are suggested to be of great importance for the metastatic potential of carcinomas.
  • RNA was extracted from 13 thyroid carcinoma cell lines and RT-PCR analysis with gene-specific primers revealed fibrillin-1 mRNA expression in all cell lines, with highest expression in the follicular carcinoma cell line WRO and lowest expression in the two anaplastic cell lines (APO, FRO).
  • Furthermore, we investigated fibrillin-1 expression by immumohistochemistry in a commercially available tissue microarray including 50 thyroid carcinomas as well as in archival tissue from 33 thyroid carcinomas.
  • Our data indicate that fibrillin-1 is strongly expressed by the neoplastic cells of thyroid carcinomas in different degree in the various histologic types and might be implicated in cell-stroma interaction in terms of signaling, attachment and migration.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Carcinoma, Medullary / pathology. Carcinoma, Papillary / pathology. Microfilament Proteins / genetics. Thyroid Neoplasms / pathology

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  • (PMID = 16528372.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Microfilament Proteins; 0 / RNA, Messenger; 0 / fibrillin
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52. Cercato MC, Colella E, Ferraresi V, Diodoro MG, Tonachella R: Report of two cases of quintuple primary malignancies and review of the literature. Anticancer Res; 2008 Sep-Oct;28(5B):2953-8

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  • Two patients surviving five primary malignant neoplasms for 12 and 18 years are reported: a 55-year-old woman with a squamous cell carcinoma of the larynx, two carcinomas of the breast, a carcinoma of the kidney and an adenocarcinoma of the colon, and a 75-year-old woman with a sarcoma of the myometrium, a carcinoma of the thyroid, an adenocarcinoma of the rectum, a leiomyosarcoma of the colon and a bronchial carcinoid.

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  • (PMID = 19031939.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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53. Pereira-Filho VA, Chaves MD, Haddad J, Gabrielli MF, Gabrielli MA, Hochulli-Vieira E, Vargas PA: Mandible metastasis as the first sign from primary adenocarcinoma of the lung. Gen Dent; 2007 May-Jun;55(3):224-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mandible metastasis as the first sign from primary adenocarcinoma of the lung.
  • Adenocarcinoma of the lung that metastasizes to the mandible is very uncommon; only a few cases have been described in the English-language literature.
  • This article presents a metastasis from adenocarcinoma of the lung affecting the mandible of a 64-year-old woman, in which the first discovered metastatic lesion was detected before the primary tumor.
  • The immunoreactivity for human thyroid transcription factor-1 (TTF-1) in the oral lesion was essential for determining the site and type of the primary tumor, as the patient showed no clinical or radiographic evidence of a tumor in the thyroid gland.
  • [MeSH-major] Adenocarcinoma / secondary. Lung Neoplasms / diagnosis. Mandibular Neoplasms / secondary

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  • (PMID = 17511366.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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54. Kakudo K, Bai Y, Katayama S, Hirokawa M, Ito Y, Miyauchi A, Kuma K: Classification of follicular cell tumors of the thyroid gland: analysis involving Japanese patients from one institute. Pathol Int; 2009 Jun;59(6):359-67
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  • [Title] Classification of follicular cell tumors of the thyroid gland: analysis involving Japanese patients from one institute.
  • Prognostic analyses of thyroid carcinomas of follicular cell origin were carried out on patients treated at Kuma Hospital, Kobe, Japan.
  • Major histological types of papillary carcinoma, follicular carcinoma and poorly differentiated carcinoma were combined into one single entity of follicular cell adenocarcinoma because (i) they have the same cell origin (follicular cell);.
  • This adenocarcinoma together with undifferentiated carcinoma was stratified into four prognostic groups using pure morphological criteria of the degree of cellular differentiation and histological grade.
  • They are termed well-differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated carcinoma and undifferentiated carcinoma of the thyroid.
  • [MeSH-major] Adenocarcinoma, Follicular / classification. Thyroid Neoplasms / classification

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  • (PMID = 19490465.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Australia
  • [Number-of-references] 67
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55. Ciobanu D, Vulpoi C, Găluşcă B, Florea N, Giuşcă SE, Căruntu ID: The value of the immunohistochemical exam in the diagnosis of the secondary malignant tumors to the thyroid gland. Rom J Morphol Embryol; 2007;48(2):113-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of the immunohistochemical exam in the diagnosis of the secondary malignant tumors to the thyroid gland.
  • The aim of the study was to analyze several cases of secondary tumors to the thyroid, by focusing on the role of the immunohistochemical (IHC) exam in specifying the origin of the tumoral process.
  • The final diagnosis was established as follows: metastases of squamocellular carcinoma with different degree of differentiation (seven cases), metastases of adenocarcinoma (four cases), metastases of renal cell carcinoma (two cases), metastases of Hodgkin (one case) and non-Hodgkin lymphoma (two cases).
  • In four cases, the primary tumors were identified after the diagnosis of their metastases in thyroid.
  • The immunohistochemical staining was useful in the diagnosis of squamocellular carcinoma metastases, poorly differentiated (CK19 positive), of renal cell carcinoma with clear cells (CK18, CK19 and CD10 positive) and in the establishing of the tumoral origin for adenocarcinomas (CK7 positive--respiratory tract, CK20 positive--digestive tract).
  • Secondary tumors to the thyroid are rare tumors, with miscellaneous histological aspects, reason for which the diagnostic may be difficult.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Renal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Immunohistochemistry / methods. Lymphoma / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / secondary
  • [MeSH-minor] Digestive System Neoplasms / diagnosis. Digestive System Neoplasms / pathology. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Male. Middle Aged. Molecular Diagnostic Techniques. Reproducibility of Results

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  • (PMID = 17641797.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Romania
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56. Sheu SY, Vogel E, Worm K, Grabellus F, Schwertheim S, Schmid KW: Hyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinoma. Histopathology; 2010 Apr;56(5):632-40
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  • [Title] Hyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinoma.
  • AIMS: To compare the expression pattern of five microRNAs (miRNAs) (146b, -181b, -21, -221, -222) of papillary thyroid carcinoma (PTC) and hyalinizing trabecular tumour of the thyroid (HTT).
  • METHODS AND RESULTS: The expression pattern of five miRNAs known to be up-regulated in PTC was retrospectively analysed in 18 HTTs, adjacent normal thyroid tissue, 10 PTCs, 10 follicular adenomas and 10 non-toxic multinodular goitres (MNG) by reverse transcriptase-polymerase chain reaction using the TaqMan miRNA assay.
  • All miRNAs were significantly up-regulated in PTCs, whereas all miRNAs in HTT, normal thyroid tissue, adenomas, and MNGs were down-regulated.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Adenoma / genetics. MicroRNAs / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Gene Rearrangement. Goiter, Nodular / genetics. Goiter, Nodular / metabolism. Goiter, Nodular / pathology. Humans. Hyalin / metabolism. Mutation. Oncogene Proteins, Fusion / genetics. Oncogene Proteins, Fusion / metabolism. Protein-Tyrosine Kinases / genetics. Protein-Tyrosine Kinases / metabolism. Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins B-raf / metabolism. Retrospective Studies. Thyroid Gland / metabolism. Thyroid Gland / pathology

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  • (PMID = 20459574.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / Oncogene Proteins, Fusion; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / ret-PTC fusion oncoproteins, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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57. Nonaka D, Tang Y, Chiriboga L, Rivera M, Ghossein R: Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms. Mod Pathol; 2008 Feb;21(2):192-200
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  • [Title] Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms.
  • Thyroid-specific transcription factors, Pax8, TTF-1, and TTF-2, are crucial for thyroid organogenesis and differentiation.
  • The goal of this study is to evaluate the expressions of these markers in thyroid tumors of the full spectrum of differentiation, with special emphasis on anaplastic carcinomas.
  • A total of 94 cases of thyroid neoplasms were studied: 17 papillary carcinomas, 18 follicular adenomas, 16 follicular carcinomas, 7 poorly differentiated carcinomas, 28 anaplastic carcinomas, and 8 medullary carcinomas.
  • Pax8 is a useful marker for the diagnosis of anaplastic carcinomas, particularly when the differential diagnosis includes pulmonary carcinoma.
  • In differentiated thyroid neoplasms, no significant difference in expression was seen in all the three transcription factors.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Adenosine Triphosphatases / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Papillary / metabolism. DNA-Binding Proteins / metabolism. Paired Box Transcription Factors / metabolism. Thyroid Neoplasms / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / metabolism. Adolescent. Adult. Aged. Aged, 80 and over. Calcitonin / metabolism. Carcinoma / diagnosis. Carcinoma / metabolism. Carcinoma, Medullary / diagnosis. Carcinoma, Medullary / metabolism. Female. Fluorescent Antibody Technique, Indirect. Humans. Hyperplasia. Immunoenzyme Techniques. Male. Middle Aged. Thyroid Gland / metabolism. Thyroid Gland / pathology. Tissue Array Analysis

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  • (PMID = 18084247.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / PAX8 protein, human; 0 / Paired Box Transcription Factors; 0 / Transcription Factors; 9007-12-9 / Calcitonin; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.1.- / TTF2 protein, human
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58. Nishida AT, Hirano S, Asato R, Tanaka S, Kitani Y, Honda N, Fujiki N, Miyata K, Fukushima H, Ito J: Multifocal hyperfunctioning thyroid carcinoma without metastases. Auris Nasus Larynx; 2008 Sep;35(3):432-6
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  • [Title] Multifocal hyperfunctioning thyroid carcinoma without metastases.
  • Hyperthyroidism due to thyroid carcinoma is rare, and most cases are caused by hyperfunctioning metastatic thyroid carcinoma rather than primary carcinoma.
  • Among primary hyperfunctioning thyroid carcinoma, multifocal thyroid carcinoma is exceedingly rare, with the only one case being reported in the literature.
  • Here, we describe the case of a 62-year-old woman with multifocal functioning thyroid carcinoma.
  • Technetium-99m (99m Tc) scintigraphic imaging showed four hot areas in the thyroid gland.
  • DNA sequencing of the thyrotropin receptor (TSH-R) gene from all nodules revealed no mutation, indicating that activation of TSH-R was unlikely in the pathophysiogenesis of hyperfunctioning thyroid carcinoma in the present case.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Hyperthyroidism / diagnosis. Neoplasms, Multiple Primary / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Female. Humans. Middle Aged. Radionuclide Imaging. Technetium. Thyroid Function Tests. Thyroid Gland / pathology. Thyroidectomy. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 17826928.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 7440-26-8 / Technetium
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59. Kaya H, Barbaros U, Erbil Y, Bozbora A, Kapran Y, Aral F, Ozarmağan S: Metastatic thyroid carcinoma. N Z Med J; 2005 Oct 28;118(1224):U1705
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  • [Title] Metastatic thyroid carcinoma.
  • Although metastases to the thyroid gland are common in autopsy studies, clinically significant metastases are rare.
  • A 58-year-old Turkish patient, presenting with thyroid metastasis 2 years after undergoing left nephrectomy for renal cell carcinoma, is reported in this case report.
  • Thyroid metastasis can be the initial presentation of renal cell carcinoma, or it may occur a long time after nephrectomy, which can lead to misdiagnosis of primary thyroid neoplasm.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Thyroid Neoplasms / secondary

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  • [CommentIn] N Z Med J. 2006;119(1235):U2013 [16751831.001]
  • (PMID = 16258580.001).
  • [ISSN] 1175-8716
  • [Journal-full-title] The New Zealand medical journal
  • [ISO-abbreviation] N. Z. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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60. Clary KM, Condel JL, Liu Y, Johnson DR, Grzybicki DM, Raab SS: Interobserver variability in the fine needle aspiration biopsy diagnosis of follicular lesions of the thyroid gland. Acta Cytol; 2005 Jul-Aug;49(4):378-82
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  • [Title] Interobserver variability in the fine needle aspiration biopsy diagnosis of follicular lesions of the thyroid gland.
  • OBJECTIVE: To study the degree of interobserver variability in the interpretation of fine needle aspiration (FNA) biopsies of the thyroid, specifically in the categorization of follicular lesions (FLs), and to examine the accuracy of FNA diagnosis of FLs with surgical follow-up.
  • STUDY DESIGN: Fifty cases were chosen with surgical follow-up and a cytologic diagnosis of either FL (21) or follicular neoplasms (29).
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Carcinoma, Papillary / pathology. Goiter, Nodular / pathology. Thyroid Neoplasms / pathology. Thyroiditis, Autoimmune / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Fine-Needle. Carcinoma, Papillary, Follicular / diagnosis. Carcinoma, Papillary, Follicular / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Observer Variation

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  • (PMID = 16124165.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Schmid KW: [Molecular pathology of thyroid tumors]. Pathologe; 2010 Oct;31 Suppl 2:229-33
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  • [Title] [Molecular pathology of thyroid tumors].
  • Molecular genetic analysis is gaining in significance for the differential diagnosis of thyroid tumours.
  • Identifying specific mutations and/or rearrangements offers not only the possibility to distinguish benign from malignant tumours, but also to classify thyroid malignancies more precisely, which can have a substantial influence on the clinical management of patients.
  • In recent years expression analysis of micro-RNA (miRNA) has become an additional tool to improve diagnostic accuracy in thyroid tumours.
  • In addition to its diagnostic contribution, molecular genetic evaluation of thyroid tumours has significantly deepened our understanding of the development, progression and therapy of these tumours.
  • [MeSH-major] DNA Mutational Analysis. Gene Rearrangement / genetics. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / genetics. Adenocarcinoma, Papillary / pathology. Carcinoma, Medullary / diagnosis. Carcinoma, Medullary / genetics. Carcinoma, Medullary / pathology. Diagnosis, Differential. Gene Expression Regulation, Neoplastic / genetics. Humans. MicroRNAs / genetics. Thyroid Carcinoma, Anaplastic. Thyroid Gland / pathology. Thyroidectomy

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  • (PMID = 20717681.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MicroRNAs
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62. Borges A, Martins M, André S: Double thyroid ectopia (with incidental papillary thyroid microcarcinoma) (2010: 8b). Eur Radiol; 2010 Nov;20(11):2768-71
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  • [Title] Double thyroid ectopia (with incidental papillary thyroid microcarcinoma) (2010: 8b).
  • Imaging was diagnostic as it disclosed an absent orthotopic thyroid gland and heterogeneous masses, with both solid and cystic components, as well as calcifications in the left sublingual/submandibular space and in the left paramedian aspect of the tongue base, consistent with double thyroid ectopia, originating from central and lateral thyroid anlages, respectively.
  • Pathology confirmed an ectopic thyroid goiter in the left submandibular space with an incidental papillary microcarcinoma.
  • Scintigraphy also demonstrated ectopic thyroid tissue in the left tongue base.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Choristoma / diagnosis. Neck. Thyroid Dysgenesis / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 20886341.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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63. Fukunari N: [Ultrasonography of thyroid cancer]. Nihon Rinsho; 2007 Nov;65(11):1997-2002
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  • [Title] [Ultrasonography of thyroid cancer].
  • The diagnosis and management of follicular carcinoma of the thyroid gland remains a controversial topic.
  • Color-Doppler (CD) imaging has been expected for the differential diagnosis between follicular adenoma and follicular carcinoma.
  • Real-time tissue elastography (RTE), which enable to demonstrate the tissue elasticity, has begun to be applied for the thyroid disease.
  • RTE can provide new useful information for the differential diagnosis of thyroid follicular lesions.
  • [MeSH-major] Adenocarcinoma, Follicular / ultrasonography. Thyroid Neoplasms / ultrasonography
  • [MeSH-minor] Diagnosis, Differential. Elasticity Imaging Techniques. Humans. Thyroidectomy. Ultrasonography, Doppler, Color

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  • (PMID = 18018561.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 14
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64. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM: Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid; 2009 Nov;19(11):1167-214
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
  • BACKGROUND: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent.
  • Since the publication of the American Thyroid Association's guidelines for the management of these disorders was published in 2006, a large amount of new information has become available, prompting a revision of the guidelines.
  • RESULTS: The revised guidelines for the management of thyroid nodules include recommendations regarding initial evaluation, clinical and ultrasound criteria for fine-needle aspiration biopsy, interpretation of fine-needle aspiration biopsy results, and management of benign thyroid nodules.
  • Recommendations regarding the initial management of thyroid cancer include those relating to optimal surgical management, radioiodine remnant ablation, and suppression therapy using levothyroxine.
  • Recommendations related to long-term management of differentiated thyroid cancer include those related to surveillance for recurrent disease using ultrasound and serum thyroglobulin as well as those related to management of recurrent and metastatic disease.
  • CONCLUSIONS: We created evidence-based recommendations in response to our appointment as an independent task force by the American Thyroid Association to assist in the clinical management of patients with thyroid nodules and differentiated thyroid cancer.
  • [MeSH-major] Adenocarcinoma / therapy. Carcinoma, Papillary / therapy. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / therapy
  • [MeSH-minor] Biopsy, Fine-Needle. Combined Modality Therapy. Diagnosis, Differential. Disease Progression. Humans. Iodine Radioisotopes / therapeutic use. Lymph Nodes / pathology. Neck. Physical Examination. Prognosis. Thyroid Gland / pathology. Treatment Outcome. United States

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  • [CommentIn] Thyroid. 2012 Feb;22(2):225-6; author reply 226-7 [22176500.001]
  • [CommentIn] Thyroid. 2013 Aug;23(8):1042-3 [23441600.001]
  • [CommentIn] Thyroid. 2009 Nov;19(11):1145-7 [19888856.001]
  • [CommentIn] Thyroid. 2009 Nov;19(11):1149-51 [19888857.001]
  • [CommentIn] Thyroid. 2015 Jul;25(7):713-5 [26079318.001]
  • [CommentIn] Thyroid. 2010 Aug;20(8):933-4; author reply 934-5 [20677999.001]
  • [CommentIn] Thyroid. 2009 Nov;19(11):1139-43 [19888855.001]
  • [ErratumIn] Thyroid. 2010 Jun;20(6):674-5
  • [ErratumIn] Thyroid. 2010 Aug;20(8):942. Hauger, Bryan R [corrected to Haugen, Bryan R]
  • (PMID = 19860577.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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65. Ogawa Y, Sugawara T, Seki H, Sakuma T: Thyroid follicular carcinoma metastasized to the lung, skull, and brain 12 years after initial treatment for thyroid gland--case report. Neurol Med Chir (Tokyo); 2006 Jun;46(6):302-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thyroid follicular carcinoma metastasized to the lung, skull, and brain 12 years after initial treatment for thyroid gland--case report.
  • A 65-year-old woman presented with multiple metastases from thyroid follicular carcinoma to the lung, skull, and brain.
  • Well-differentiated thyroid carcinoma is a slowly progressive tumor.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Brain Neoplasms / secondary. Epidural Neoplasms / secondary. Lung Neoplasms / secondary. Postoperative Complications / pathology. Radiosurgery. Skull Neoplasms / secondary. Thyroid Neoplasms / radiotherapy. Thyroid Neoplasms / surgery

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  • (PMID = 16794352.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; Q51BO43MG4 / Thyroxine
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66. Marioni G, De Filippis C, Ottaviano G, Lorusso M, Staffieri C, Bernini G, Blandamura S: Laryngeal metastasis from sigmoid colon adenocarcinoma followed by peristomal recurrence. Acta Otolaryngol; 2006 Jun;126(6):661-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laryngeal metastasis from sigmoid colon adenocarcinoma followed by peristomal recurrence.
  • Colonic adenocarcinoma metastases to the larynx are extremely rare: only 13 cases have been described since 1972.
  • We present the first case of sigmoid colon adenocarcinoma metastasis to the larynx in a patient who developed peristomal malignancy recurrence after total laryngectomy.
  • Patients with metastasis of colonic adenocarcinoma to the larynx usually present with disseminated disease: in view of the poor chances of long-term survival of these patients conservative palliative laryngeal treatments should be carried out to improve the quality of life.
  • [MeSH-major] Adenocarcinoma / secondary. Laryngeal Neoplasms / secondary. Laryngectomy. Neoplasm Recurrence, Local / diagnosis. Sigmoid Neoplasms / diagnosis. Tracheostomy
  • [MeSH-minor] Aged. Biopsy, Needle. Female. Humans. Larynx / pathology. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Reoperation. Thyroid Gland / pathology. Thyroid Neoplasms / pathology. Thyroid Neoplasms / secondary. Thyroid Neoplasms / surgery. Thyroidectomy

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  • (PMID = 16720454.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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67. Chaturvedi S, Gupta S, Kumari R: Meningioma with metastasis from follicular carcinoma thyroid. Indian J Pathol Microbiol; 2010 Apr-Jun;53(2):316-8
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  • [Title] Meningioma with metastasis from follicular carcinoma thyroid.
  • On the basis of radiological investigations, provisional diagnosis of basal meningioma was made.
  • Tissue sent for histopathological evaluation revealed a dual tumor-meningioma with metastasis from follicular carcinoma, thyroid.
  • To the best of authors' knowledge, this is the first report of a tumor metastasizing to another tumor, where a follicular carcinoma thyroid metastasized to meningioma.
  • [MeSH-major] Adenocarcinoma, Follicular / complications. Adenocarcinoma, Follicular / diagnosis. Meningioma / diagnosis. Meningioma / secondary
  • [MeSH-minor] Blindness / etiology. Face / pathology. Female. Head / radiography. Histocytochemistry. Humans. Hypesthesia / etiology. Immunohistochemistry. Magnetic Resonance Imaging. Microscopy. Middle Aged. Thyroid Gland / pathology. Tomography, X-Ray Computed

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  • (PMID = 20551543.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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68. Kobayashi M, Hattori M, Miyamoto T, Kakinuma H, Watanabe J, Iwabuchi K, Nishimura Y, Jobo T, Kuramoto H: Basement membrane-like substance in cytologic diagnosis in clear cell adenocarcinoma of the minor salivary gland of the palate. A case report. Acta Cytol; 2007 Nov-Dec;51(6):916-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basement membrane-like substance in cytologic diagnosis in clear cell adenocarcinoma of the minor salivary gland of the palate. A case report.
  • BACKGROUND: Clear cell adenocarcinoma (CCA) of the minor salivary gland accounts for < 1% of all tumors of the salivary gland.
  • CASE: A 32-year-old woman with a history of papillary carcinoma of the thyroid 1 year earlier complained of pain on the left side of the neck.
  • CONCLUSION: Although CCA of the palate is extremely rare, an accurate cytologic diagnosis can be made if the characteristic findings of CCA, including BMS, are imaged.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Basement Membrane / pathology. Palatal Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 18077986.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Laminin
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69. Dralle H, Lorenz K, Machens A, Nguyen Thanh P: [Thyroid carcinoma found incidentally after thyroidectomy: postoperative strategy]. Dtsch Med Wochenschr; 2009 Dec;134(49):2517-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Thyroid carcinoma found incidentally after thyroidectomy: postoperative strategy].
  • Completion operations after thyroid surgery due to incidental postoperative diagnosis of thyroid cancer are indicated in differentiated thyroid cancer with tumor size > 1 cm, extrathyroidal invasion, multifocality, angioinvasion or metastases.
  • By thorough preoperative clinical work-up of nodular goiter (ultrasonography, fine needle aspiration cytology the frequency of completion thyroidectomies are aimed to be less than 10% of all thyroid cancer operations.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Carcinoma, Medullary / diagnosis. Carcinoma, Medullary / surgery. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Goiter / pathology. Goiter / surgery. Incidental Findings. Postoperative Complications / diagnosis. Postoperative Complications / surgery. Thyroidectomy
  • [MeSH-minor] Biopsy, Fine-Needle. Calcitonin / blood. Disease Progression. Frozen Sections. Humans. Lymph Node Excision. Lymph Nodes / pathology. Neoplasm Invasiveness. Neoplastic Cells, Circulating / pathology. Reoperation / methods. Thyroid Gland / pathology. Ultrasonography

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  • [Copyright] Copyright Georg Thieme Verlag KG Stuttgart New York
  • (PMID = 19941236.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 9007-12-9 / Calcitonin
  • [Number-of-references] 22
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70. Prodam F, Pagano L, Belcastro S, Golisano G, Busti A, Samà M, Caputo M, Bellone S, Voci A, Valente G, Aimaretti G: Pituitary metastases from follicular thyroid carcinoma. Thyroid; 2010 Jul;20(7):823-30
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  • [Title] Pituitary metastases from follicular thyroid carcinoma.
  • BACKGROUND: Metastatic carcinomas to the pituitary gland are uncommon, occurring in only 1% of the pituitary masses.
  • Here we describe a patient with pituitary metastasis from follicular thyroid carcinoma and discuss the unique features of these lesions.
  • Histopathology revealed a metastasis with well-differentiated follicular thyroid architecture.
  • Total thyroidectomy and lymph node dissection was performed with a final histopathological diagnosis of follicular thyroid carcinoma.
  • CONCLUSIONS: Pituitary metastases from thyroid carcinoma are very uncommon.
  • As this patient illustrates, they tend to produce symptoms relating to space-occupying expansion in the parasellar region rather than to those due to destruction of the pituitary gland.
  • Although rare, pituitary metastases caused by thyroid malignancy should be considered in patients with expanding parasellar lesions if they have thyroid cancer or uncharacterized thyroid diseases.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Neoplasm Recurrence, Local / pathology. Pituitary Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 20604687.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 9010-34-8 / Thyroglobulin
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71. Tavangar SM, Monajemzadeh M, Larijani B, Haghpanah V: Immunohistochemical study of oestrogen receptors in 351 human thyroid glands. Singapore Med J; 2007 Aug;48(8):744-7
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  • [Title] Immunohistochemical study of oestrogen receptors in 351 human thyroid glands.
  • INTRODUCTION: It is well recognised that the pathogenesis of thyroid diseases is complex and different factors such as genetic factors, iodine deficiency, sex, age, radiation therapy in childhood, growth stimulating antibodies, and other epithelial growth factors can influence them.
  • Epidemiological features of thyroid tumours and experimental evidence suggest that female sex hormones may exert effects on the thyroid gland and its neoplasms.
  • This possibility was addressed by investigating the expression of oestrogen receptor protein in 351 thyroid lesions.
  • METHODS: The tissues from 351 human thyroid glands comprising 130 nodular goitres and 221 neoplastic lesions were used for the present immunohistochemical assessment of oestrogen receptor expression.
  • The incidence of oestrogen receptor positivity, which is compatible with other studies, is higher in well-differentiated thyroid lesions.
  • CONCLUSION: The relatively high proportion of oestrogen receptor positivity in goitres, follicular adenomas and papillary carcinomas, compared with its reactivity in other thyroid neoplasms, and contrasted against normal thyroid tissue, suggests that the incidence of oestrogen receptor reactivity tends to increase with better differentiation of thyroid lesions.
  • [MeSH-major] Goiter / metabolism. Receptors, Estrogen / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenoma / metabolism. Adult. Carcinoma, Papillary / metabolism. Female. Humans. Immunohistochemistry. Male

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  • (PMID = 17657383.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Receptors, Estrogen
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72. Bian X, Tang PZ: [Analysis of different proteins expression between papillary thyroid carcinoma and normal thyroid tissue]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Apr;45(4):318-23
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  • [Title] [Analysis of different proteins expression between papillary thyroid carcinoma and normal thyroid tissue].
  • OBJECTIVE: In order to understand the mechanisms of tumor development and identify potential new biomarkers of human papillary thyroid carcinoma (PTC), the different proteins expression were investigated and analyzed between PTC and normal thyroid tissue.
  • METHODS: By using immobilized pH gradient (IPG)-based two-dimensional gel electrophoresis (2-DE), the total proteins were separated and 2-DE maps were established for PTC and normal thyroid tissue, respectively.
  • RESULTS: The 2-DE maps of PTC and normal thyroid tissue was established.
  • In comparison with normal thyroid tissue, a total of eleven proteins were up-regulated such as Cyclin-D2, Manganese SOD and Galectin-3; while six proteins were down-regulated including Peroxiredoxin-2, Hsp70 and Hsp27.
  • CONCLUSIONS: Group of differential expressed proteins between PTC and normal thyroid tissue was identified.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. Proteome. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism

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  • (PMID = 20627053.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Proteome
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73. Savin S, Cvejic D, Isic T, Paunovic I, Tatic S, Havelka M: The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma. Exp Oncol; 2006 Mar;28(1):70-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma.
  • AIM: Expression of thyroid peroxidase (TPO) in the thyroid gland tissue is well known as a sensitive marker of the thyroid malignancy.
  • We have evaluated immunohistochemical assay of TPO for distinguishing follicular thyroid carcinoma from follicular adenoma.
  • MATERIALS AND METHODS: Sections of formalin-fixed tissues obtained from 92 patients with thyroid tumors (52 follicular carcinomas and 40 follicular adenomas including the Hurthle cell type) were analyzed using a monoclonal antibody (TPO mAb 47) and the avidin-biotin peroxidase complex immunohistochemical technique.
  • RESULTS: TPO immunostaining correlated with the histopathological diagnosis in 24/40 cases of follicular adenomas and 41/52 cases of follicular carcinomas, giving a specificity of 60% and a sensitivity of 79%.
  • CONCLUSION: These results suggest that immunohistochemical assay of TPO expression has limited value for the differential diagnosis of follicular thyroid carcinoma from thyroid follicular adenoma.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenoma / pathology. Iodide Peroxidase / metabolism. Thyroid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry

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  • (PMID = 16614712.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.11.1.8 / Iodide Peroxidase
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74. Park CS, Kim SH, Jung SL, Kang BJ, Kim JY, Choi JJ, Sung MS, Yim HW, Jeong SH: Observer variability in the sonographic evaluation of thyroid nodules. J Clin Ultrasound; 2010 Jul;38(6):287-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Observer variability in the sonographic evaluation of thyroid nodules.
  • OBJECTIVE: Inter- and intraobserver variabilities in the description and diagnostic categorization of sonographic (US) features of thyroid nodules were evaluated.
  • The US findings for each thyroid nodule were analyzed twice at a 6-week interval by five radiologists.
  • The analyses were in accordance with the guidelines proposed by the Thyroid Study Group of the Korean Society of Neuroradiology and Head and Neck Radiology (TSGKSNRHNR).
  • Of the US features of the thyroid nodules, internal content (solid versus cystic) showed substantial agreement (k = 0.64).
  • CONCLUSION: There were high degrees of inter- and intraobserver agreement using the "Guidelines for diagnostic thyroid ultrasonography," of the TSGKSNRHNR in the description and categorization of thyroid nodules.
  • [MeSH-major] Adenocarcinoma, Follicular / ultrasonography. Carcinoma, Medullary / ultrasonography. Carcinoma, Papillary / ultrasonography. Thyroid Gland / ultrasonography. Thyroid Nodule / ultrasonography
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Observer Variation. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Thyroid Diseases / ultrasonography

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  • (PMID = 20544863.001).
  • [ISSN] 1097-0096
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Yeh YC, Chou TY: Pulmonary adenocarcinoma with microcystic histology and intratumoral heterogeneity of EGFR gene polymorphism. Histopathology; 2010 Jul;57(1):112-20
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  • [Title] Pulmonary adenocarcinoma with microcystic histology and intratumoral heterogeneity of EGFR gene polymorphism.
  • MATERIALS AND RESULTS: Two cases of pulmonary adenocarcinoma exhibiting a unique microcystic growth pattern were analysed.
  • The tumour cells were immunoreactive with thyroid transcription factor-1 (TTF-1), which helped to differentiate them from salivary gland-type tumours.
  • CONCLUSIONS: Pulmonary microcystic adenocarcinoma has a variable clinical outcome.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Genes, erbB-1. Lung Neoplasms / genetics. Lung Neoplasms / pathology. Polymorphism, Single Nucleotide

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  • (PMID = 20653783.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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76. Kilfoy BA, Devesa SS, Ward MH, Zhang Y, Rosenberg PS, Holford TR, Anderson WF: Gender is an age-specific effect modifier for papillary cancers of the thyroid gland. Cancer Epidemiol Biomarkers Prev; 2009 Apr;18(4):1092-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gender is an age-specific effect modifier for papillary cancers of the thyroid gland.
  • BACKGROUND: Thyroid cancer incidence rates have increased worldwide for decades, although more for papillary carcinomas than other types and more for females than males.
  • There are few known thyroid cancer risk factors except female gender, and the reasons for the increasing incidence and gender differences are unknown.
  • METHODS: We used the National Cancer Institute's Surveillance, Epidemiology, and End Results 9 Registries Database for cases diagnosed during 1976-2005 to develop etiological clues regarding gender-related differences in papillary thyroid cancer incidence.
  • RESULTS: The papillary thyroid cancer incidence rate among females was 2.6 times that among males (9.2 versus 3.6 per 100,000 person-years, respectively), with a widening gender gap over time.
  • APC models for papillary thyroid cancers confirmed statistically different age-specific effects among women and men (P < 0.001 for the null hypothesis of no difference by gender), adjusted for calendar-period and birth-cohort effects.
  • CONCLUSION: Gender was an age-specific effect modifier for papillary thyroid cancer incidence.
  • Future analytic studies attempting to identify the risk factors responsible for rising papillary thyroid cancer incidence should be designed with adequate power to assess this age-specific interaction among females and males.

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  • [Cites] Eur J Cancer. 2001 Oct;37 Suppl 8:S4-66 [11602373.001]
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  • (PMID = 19293311.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / TU2 CA105666; United States / Intramural NIH HHS / / Z01 CP010183-05; United States / NCI NIH HHS / CA / TU2CA105666
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS96006; NLM/ PMC2667567
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77. Liou MJ, Lin JD, Chung MH, Liau CT, Hsueh C: Renal metastasis from papillary thyroid microcarcinoma. Acta Otolaryngol; 2005 Apr;125(4):438-42
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  • [Title] Renal metastasis from papillary thyroid microcarcinoma.
  • Papillary or follicular microcarcinoma of the thyroid comprises 10-20% of all thyroid malignancies.
  • Distant metastasis caused by thyroid microcarcinoma is uncommon, and is usually found in the lung or bone.
  • Thyroid microcarcinoma with metastasis to the kidney has not previously been reported.
  • Clinically detectable well-differentiated metastatic thyroid carcinoma to the kidney is rare, and only 16 cases have been reported.
  • Herein we describe a case of metastatic papillary thyroid microcarcinoma to the kidney in a patient with a pelvic fracture and pulmonary metastasis.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Adenocarcinoma, Papillary / secondary. Kidney Neoplasms / secondary. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Bone Neoplasms / diagnosis. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Calcinosis / diagnosis. Calcinosis / pathology. Disease Progression. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Middle Aged. Pelvic Bones / pathology. Thyroglobulin / blood. Thyroid Gland / pathology. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 15823819.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 9010-34-8 / Thyroglobulin
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78. Rago T, Di Coscio G, Basolo F, Scutari M, Elisei R, Berti P, Miccoli P, Romani R, Faviana P, Pinchera A, Vitti P: Combined clinical, thyroid ultrasound and cytological features help to predict thyroid malignancy in follicular and Hupsilonrthle cell thyroid lesions: results from a series of 505 consecutive patients. Clin Endocrinol (Oxf); 2007 Jan;66(1):13-20
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  • [Title] Combined clinical, thyroid ultrasound and cytological features help to predict thyroid malignancy in follicular and Hupsilonrthle cell thyroid lesions: results from a series of 505 consecutive patients.
  • The diagnostic value of atypia at cytology, clinical parameters and echographic patterns were examined to establish the risk of malignancy in 505 patients with follicular and Hupsilonrthle cell thyroid nodules at cytology.
  • RESULTS: Histological diagnosis of malignancy was carried out in 125 of 505 (25%) patients, the follicular variant of papillary carcinoma being the most frequent histotype.
  • Male gender, normal thyroid volume, single nodularity, nodule hypoechogenicity, size and blurred margins were associated with malignancy, although not significantly.
  • CONCLUSIONS: Twenty-five per cent of patients with a cytological result of follicular and Hupsilonrthle cell thyroid lesion had a final diagnosis of malignancy.
  • Only atypia at cytology and spot microcalcifications at thyroid ultrasound were significantly associated with malignancy.
  • Other clinical parameters and thyroid ultrasound patterns can be used to set up a clinical score useful for predicting the individual risk of malignancy before surgery.
  • [MeSH-major] Thyroid Gland / pathology. Thyroid Neoplasms / pathology. Thyroid Nodule / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / ultrasonography. Adenoma / pathology. Adenoma / ultrasonography. Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / ultrasonography. Adult. Biopsy, Fine-Needle. Calcinosis / ultrasonography. Carcinoma, Medullary / pathology. Carcinoma, Medullary / ultrasonography. Carcinoma, Papillary, Follicular / pathology. Carcinoma, Papillary, Follicular / ultrasonography. Chi-Square Distribution. Cytodiagnosis. Diagnosis, Differential. Female. Humans. Hyperplasia. Male. Middle Aged. Predictive Value of Tests

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  • (PMID = 17201796.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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79. Lyshchik A, Higashi T, Asato R, Tanaka S, Ito J, Hiraoka M, Brill AB, Saga T, Togashi K: Elastic moduli of thyroid tissues under compression. Ultrason Imaging; 2005 Apr;27(2):101-10
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  • [Title] Elastic moduli of thyroid tissues under compression.
  • The aim of this study was to evaluate the elastic moduli of thyroid tissues under uniaxial compression and to establish the biomechanical fundamentals for accurate interpretation of thyroid elastograms.
  • A total of 67 thyroid samples (24 samples of normal thyroid tissue, 2 samples of thyroid tissue with chronic thyroiditis, 12 samples of adenomatous goiter lesions and 7 samples of follicular adenoma, 19 samples of papillary adenocarcinoma (PAC) and 3 samples of follicular adenocarcinoma (FAC)) obtained from 36 patients who had received thyroid surgery were subjected to biomechanical testing within three hours after surgical resection at precompression strains of 5%, 10% and 20% and applied strains of 1%, 2%, 5% and 10% of sample height.
  • As a result, the mean values of elastic moduli for benign thyroid lesions at all examined precompression levels were significantly higher than those for normal thyroid tissue measured at the same load (p<0.01).
  • At low precompression (5%) and compression (1-2%) levels, benign thyroid nodule samples were 1.7 times harder than normal thyroid tissue.
  • Stiffness of PAC samples was significantly higher than those for normal thyroid tissue and benign thyroid tumors measured at the same load (p<0.01).
  • At low precompression (5%) and compression (1-2%) levels, PAC samples were 5.0 times harder than normal thyroid tissue.
  • In contrast, samples of FAC were much softer than PAC (p<0.05) and were comparable in stiffness to normal thyroid tissues.
  • The significant differences in the stiffness between normal thyroid tissue and thyroid tumors may provide useful information for accurate interpretation of thyroid elastograms.
  • [MeSH-major] Elasticity. Stress, Mechanical. Thyroid Diseases / diagnostic imaging. Thyroid Gland / diagnostic imaging

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  • (PMID = 16231839.001).
  • [ISSN] 0161-7346
  • [Journal-full-title] Ultrasonic imaging
  • [ISO-abbreviation] Ultrason Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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80. Ettl T, Kleinheinz J, Mehrotra R, Schwarz S, Reichert TE, Driemel O: The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma--report of a case. Head Face Med; 2008;4:16
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  • [Title] The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma--report of a case.
  • BACKGROUND: With the 2005 WHO classification of salivary gland tumours and its increasingly recognized diagnostic entities, the frequency of adenocarcinoma (NOS) has decreased significantly.
  • CASE PRESENTATION: This paper describes a fast growing adenocarcinoma (NOS), originating from the minor salivary glands of the left buccal mucosa with a rapid onset of multiple local and distant metastases, especially in the lung.
  • A lung primary was unlikely as the tumour was characterized by positivity for cytokeratin 20 and negativity for the thyroid transcription factor-1 protein (TTF-1) in immunohistochemistry.
  • CONCLUSION: A rare case of an adenocarcinoma (NOS) of the minor salivary glands with a rapid development and an unfavourable clinical course is reported.
  • [MeSH-major] Adenocarcinoma / secondary. Lung Neoplasms / secondary. Neoplasm Metastasis. Salivary Gland Neoplasms / pathology

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  • (PMID = 18667060.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
  • [Other-IDs] NLM/ PMC2515301
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81. Anderson CE, Graham C, Herriot MM, Kamel HM, Salter DM: CD98 expression is decreased in papillary carcinoma of the thyroid and Hashimoto's thyroiditis. Histopathology; 2009 Dec;55(6):683-6
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  • [Title] CD98 expression is decreased in papillary carcinoma of the thyroid and Hashimoto's thyroiditis.
  • CD98 expression is increased in a variety of carcinomas but its distribution in the normal and neoplastic thyroid gland has not been reported.
  • The aim was to examine the immunohistochemical expression of CD98 in normal and diseased thyroid tissue.
  • METHODS AND RESULTS: One hundred and forty thyroid cases were selected from the archives of the Department of Pathology, including normal controls, neoplasms (follicular adenoma, follicular carcinoma and papillary carcinoma) and non-neoplastic conditions (multinodular goitre, Graves' disease and Hashimoto's thyroiditis).
  • In normal thyroid, there was moderately strong expression of CD98 in the lateral cell membranes of follicular cells.
  • CONCLUSIONS: CD98 expression is down-regulated in thyroid papillary carcinoma; this may relate to the better prognosis associated with many of these tumours.
  • [MeSH-major] Antigens, CD98 / metabolism. Carcinoma, Papillary / metabolism. Hashimoto Disease / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenoma / metabolism. Down-Regulation. Graves Disease / metabolism. Humans. Immunohistochemistry. Prognosis

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  • (PMID = 19922591.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD98
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82. Cozzolino I, Malapelle U, Carlomagno C, Palombini L, Troncone G: Metastasis of colon cancer to the thyroid gland: a case diagnosed on fine-needle aspirate by a combined cytological, immunocytochemical, and molecular approach. Diagn Cytopathol; 2010 Dec;38(12):932-5
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  • [Title] Metastasis of colon cancer to the thyroid gland: a case diagnosed on fine-needle aspirate by a combined cytological, immunocytochemical, and molecular approach.
  • Fine-needle aspiration (FNA) with cytological evaluation reliably diagnoses primary and secondary thyroid neoplasms.
  • However, identifying the primary origin of a metastatic process involving the thyroid gland is challenging.
  • In particular, metastasis of colon cancer to the thyroid gland is very rare.
  • In this case report, a right lobe solid thyroid nodule in a 66-year-old male was aspirated.
  • Since KRAS codon 12/13 mutations frequently occur in colon cancer, whereas they are extremely uncommon in primary thyroid tumors, DNA was extracted from the aspirated cells, and KRAS mutational analysis was carried out.
  • Thus, a combined cytological, immunocytochemical and molecular approach unquestionably correlated metastatic adenocarcinoma cells aspirated from the thyroid to a colo-rectal origin.
  • [MeSH-major] Colonic Neoplasms / pathology. Molecular Diagnostic Techniques / methods. Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / secondary

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20213843.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 3.6.5.2 / ras Proteins
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83. Musholt PB, Musholt TJ, Morgenstern SC, Worm K, Sheu SY, Schmid KW: Follicular histotypes of oncocytic thyroid carcinomas do not carry mutations of the BRAF hot-spot. World J Surg; 2008 May;32(5):722-8
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  • [Title] Follicular histotypes of oncocytic thyroid carcinomas do not carry mutations of the BRAF hot-spot.
  • BACKGROUND: The BRAF V600E mutation is the most prevalent genetic aberration in papillary thyroid carcinomas (PTCs), and it is found exclusively in RET/PTC-negative tumors.
  • In oncocytic (Hürthle cell, oxyphilic) thyroid tumors, the presence of RET/PTC rearrangements is associated with either the conventional papillary histotype or the "solid" Hürthle cell tumors, whereas all predominantly follicular oncocytic carcinomas do not harbor RET/PTC chimeras.
  • Although 12% of tumors of the follicular variant of PTC carry BRAF mutations, none of the few oncocytic follicular thyroid adenomas (oncoAd) or carcinomas (oncoFTC) published worldwide tested positive.
  • An aspired molecular-based classification of oncocytic thyroid tumors is in need of additional evidence on BRAF mutations in the follicular histotype.
  • METHODS: A series of 44 oncocytic thyroid tumors with well-documented clinicopathological data was subjected to BRAF mutation analysis (complete exon 15) by automated sequencing.
  • RESULTS: The series of oncocytic thyroid tumors consisted of 21 adenomas (oncoAds: 17 females, 4 males; mean age, 54.5 years; range, 27-80 years), 20 follicular carcinomas (oncoFTCs: 14 females, 6 males; mean age, 61.4 years; range, 39-80 years), and 3 "classic" papillary carcinomas (oncoPTCs: 3 females; mean age, 58.1 years; range, 46-70 years; 3x T2 tumors).
  • CONCLUSIONS: Our results add to the evidence that, in contrast to follicular variants of oncoPTCs, predominantly follicular oncocytic thyroid tumors harbor neither RET/PTC rearrangements nor BRAF mutations.
  • Furthermore, the findings support the concept that oncocytic neoplasms of the thyroid gland are oncocytic counterparts of the respective histotype (adenoma, FTC, PTC, or poorly differentiated thyroid carcinoma) rather than a separate tumor entity.
  • Molecular characterization of oncocytic thyroid malignancies for RET/PTC or BRAF genetic alterations may help with (preoperative) classification and prognostic evaluation of these tumors.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenoma, Oxyphilic / genetics. Carcinoma, Papillary / genetics. Mutation. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 18235983.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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84. Saghir SA, Charles GD, Bartels MJ, Kan LH, Dryzga MD, Brzak KA, Clark AJ: Mechanism of trifluralin-induced thyroid tumors in rats. Toxicol Lett; 2008 Jul 30;180(1):38-45
Hazardous Substances Data Bank. LIOTHYRONINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mechanism of trifluralin-induced thyroid tumors in rats.
  • Trifluralin, an herbicide, has been reported to cause a significant increase in thyroid follicular cell tumors in male Fischer 344 rats.
  • This study was designed to determine the mechanism of thyroid hyperactivity after trifluralin exposure.
  • The increased levels of TSH with chronic exposure to trifluralin would exert a continuous stimulation of the thyroid gland leading to cellular hypertrophy and proliferation predisposing to the development of follicular cell tumors in rats.
  • [MeSH-major] Adenocarcinoma, Follicular / chemically induced. Herbicides / toxicity. Thyroid Gland / drug effects. Thyroid Neoplasms / chemically induced. Trifluralin / toxicity

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  • Hazardous Substances Data Bank. TRIFLURALIN .
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  • (PMID = 18582544.001).
  • [ISSN] 0378-4274
  • [Journal-full-title] Toxicology letters
  • [ISO-abbreviation] Toxicol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Herbicides; 0 / RNA, Messenger; 06LU7C9H1V / Triiodothyronine; 9002-71-5 / Thyrotropin; C8BX46QL7K / Trifluralin; EC 2.4.1.17 / Glucuronosyltransferase; Q51BO43MG4 / Thyroxine
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85. Puente S, Velasco A, Gallel P, Pallares J, Perez-Ruiz L, Ros S, Maravall J, Matias-Guiu X: Metastatic small cell carcinoma to the thyroid gland: a pathologic and molecular study demonstrating the origin in the urinary bladder. Endocr Pathol; 2008;19(3):190-6
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  • [Title] Metastatic small cell carcinoma to the thyroid gland: a pathologic and molecular study demonstrating the origin in the urinary bladder.
  • Small cell carcinomas may occur in the thyroid gland.
  • Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma.
  • However, the vast majority of small cell carcinomas involving the thyroid gland are metastatic tumors.
  • An example of a small cell carcinoma metastatic to the thyroid is presented in this report.
  • The microscopical and immunohistochemical features of both tumors, in the thyroid and the bladder, were identical.
  • [MeSH-major] Carcinoma, Small Cell / genetics. Carcinoma, Small Cell / secondary. Thyroid Neoplasms / genetics. Thyroid Neoplasms / secondary. Urinary Bladder Neoplasms / genetics. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Base Sequence. Carcinoma, Transitional Cell / pathology. DNA Methylation. DNA Mutational Analysis. Humans. Immunohistochemistry. Loss of Heterozygosity. Male. Middle Aged. Neoplasms, Multiple Primary / pathology. Promoter Regions, Genetic / genetics. Prostatic Neoplasms / pathology. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 18446450.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RASSF1 protein, human; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins
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86. Shamim MS, Khursheed F, Bari ME, Chisti KN, Enam SA: Follicular thyroid carcinoma presenting as solitary skull metastasis: report of two cases. J Pak Med Assoc; 2008 Oct;58(10):575-7
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  • [Title] Follicular thyroid carcinoma presenting as solitary skull metastasis: report of two cases.
  • We report two otherwise healthy patients with no prior history of thyroid cancer, who presented to us with a solitary scalp lump.
  • Histopathological examination revealed metastases from well differentiated follicular thyroid carcinoma (FTC).
  • Subsequent workup confirmed occult primary carcinoma of the thyroid gland in both patients.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Skull Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 18998315.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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87. Aslam R, Steward D: Surgical management of thyroid disease. Otolaryngol Clin North Am; 2010 Apr;43(2):273-83, viii
MedlinePlus Health Information. consumer health - Thyroid Diseases.

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  • [Title] Surgical management of thyroid disease.
  • The surgical management of thyroid disease and its indications continue to evolve.
  • This article describes the surgical management of various thyroid pathologies.
  • [MeSH-major] Thyroid Diseases / surgery. Thyroid Neoplasms / surgery. Thyroidectomy / methods
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / surgery. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Diagnostic Imaging. Goiter, Nodular / diagnosis. Goiter, Nodular / pathology. Goiter, Nodular / surgery. Goiter, Substernal / diagnosis. Goiter, Substernal / pathology. Goiter, Substernal / surgery. Humans. Sensitivity and Specificity. Thyroid Gland / pathology. Thyroid Nodule / diagnosis. Thyroid Nodule / pathology. Thyroid Nodule / surgery

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20510714.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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88. Mattioli F, Martelli A, Gosmar M, Garbero C, Manfredi V, Varaldo E, Torre GC, Brambilla G: DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by chemicals carcinogenic to the rat thyroid. Mutat Res; 2006 Oct 30;609(2):146-53
Hazardous Substances Data Bank. NITROBENZENE .

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  • [Title] DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by chemicals carcinogenic to the rat thyroid.
  • Five chemicals that are known to induce in rats thyroid follicular-cell adenomas and carcinomas were assayed for their ability to induce DNA damage and DNA repair synthesis in primary cultures of human thyroid cells.
  • Under the same experimental conditions, DNA repair synthesis, as evaluated by quantitative autoradiography, was present in potassium bromate-exposed thyroid cells from all the three donors and in those from two of three donors with either nitrobenzene or ethylenethiourea, but did not match the criteria for a positive response in thyroid cells from any of the donors with methimazole and N,N'-diethylthiourea.
  • Consistently with their ability to induce thyroid tumors, all the five test compounds, administered p.o. in rats in a single dose corresponding to 1/2 LD50, induced a statistically significant degree of DNA fragmentation in the thyroid.
  • These findings suggest that the five test compounds might be carcinogenic to thyroid in humans.
  • [MeSH-major] Carcinogens / toxicity. DNA Fragmentation / drug effects. DNA Repair / drug effects. Thyroid Gland / drug effects. Thyroid Gland / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / chemically induced. Adenoma / chemically induced. Animals. Bromates / toxicity. Cells, Cultured. DNA Damage. Ethylenethiourea / toxicity. Humans. In Vitro Techniques. Kidney / drug effects. Kidney / metabolism. Liver / drug effects. Liver / metabolism. Male. Methimazole / toxicity. Nitrobenzenes / toxicity. Rats. Rats, Sprague-Dawley. Thiourea / analogs & derivatives. Thiourea / toxicity. Thyroid Neoplasms / chemically induced

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  • (PMID = 16942904.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bromates; 0 / Carcinogens; 0 / Nitrobenzenes; 04MB35W6ZA / potassium bromate; 24FOJ4N18S / Ethylenethiourea; 26914-14-7 / diethylthiourea; 554Z48XN5E / Methimazole; E57JCN6SSY / nitrobenzene; GYV9AM2QAG / Thiourea
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89. Urken ML: Prognosis and management of invasive well-differentiated thyroid cancer. Otolaryngol Clin North Am; 2010 Apr;43(2):301-28, viii
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognosis and management of invasive well-differentiated thyroid cancer.
  • Invasive thyroid cancer is often asymptomatic and can take the surgeon and the patient by surprise.
  • Specific guidelines are provided for the management of the various structures in the neck that are at risk for involvement by disease extension outside the gland or extracapsular extension outside a lymph node with involvement by metastatic disease.
  • This article reviews the prognosis, diagnosis, management, and implications of invasive thyroid cancer affecting the various structures of the central and lateral compartments of the neck.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / surgery. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery
  • [MeSH-minor] Disease Progression. Esophagus / pathology. Esophagus / surgery. Humans. Jugular Veins / pathology. Jugular Veins / surgery. Larynx / pathology. Larynx / surgery. Lymph Node Excision / methods. Lymphatic Metastasis / pathology. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Recurrent Laryngeal Nerve / pathology. Recurrent Laryngeal Nerve / surgery. Suture Techniques. Thyroid Gland / pathology. Trachea / pathology. Trachea / surgery

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20510716.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
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90. Wirtz G, Quoix E, Grunenberger F, Massard G, Mennecier B: [Thyroid metastasis of lung cancer and abnormal thyroid function--a case report]. Rev Pneumol Clin; 2009 Feb;65(1):27-31
MedlinePlus Health Information. consumer health - Thyroid Cancer.

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  • [Title] [Thyroid metastasis of lung cancer and abnormal thyroid function--a case report].
  • The thyroid gland is a very rare location of metastasis and the metastatic involvement of the thyroid is mostly asymptomatic.
  • The authors report one of the first cases of pulmonary adenocarcinoma associated with painful metastatic involvement of the thyroid gland.
  • The evolution after five cycles of chemotherapy by cisplatine and docetaxel was marked by a complete regression of the thyroid metastasis and an improvement in the thyroid function.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Hyperthyroidism / etiology. Hypothyroidism / etiology. Lung Neoplasms / pathology. Thyroid Neoplasms / secondary


91. Albores-Saavedra J, Wu J: The many faces and mimics of papillary thyroid carcinoma. Endocr Pathol; 2006;17(1):1-18
MedlinePlus Health Information. consumer health - Thyroid Cancer.

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  • [Title] The many faces and mimics of papillary thyroid carcinoma.
  • This article provides an overview of the 15 histologic variants of papillary thyroid carcinoma listed by the 2004 World Health Organization (WHO) monograph on endocrine tumors.
  • The histologic features, differential diagnosis, and clinical course of each variant are discussed in some detail.
  • Moreover, hyperplastic thyroid lesions, follicular adenomas, and Hashimoto's thyroiditis may contain cells with clear nuclei resembling those of papillary carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenoma / diagnosis. Cell Nucleus / pathology. Diagnosis, Differential. Hashimoto Disease / diagnosis. Humans. Hyperplasia / diagnosis. Thyroid Gland / pathology. World Health Organization

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  • (PMID = 16760576.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 68
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92. Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM: Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol; 2005 Mar;29(3):359-67
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
  • We concluded that CK17 is a useful marker in separating pancreatobiliary adenocarcinomas from extra-pancreatobiliary nonmucinous adenocarcinomas, including adenocarcinomas from the colon, breast, gynecologic organs, stomach, lung, prostate, thyroid, kidney, and adrenal gland, and malignant mesothelioma.
  • MUC2+/CDX2+ can be used as positive markers for the intestinal-type adenocarcinoma of duodenal papillary origin with a positive predictive value of 82%.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Keratins / metabolism. Male. Mucins / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 15725805.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Mucins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
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93. Liu XH, Chen GG, Vlantis AC, van Hasselt CA: Iodine mediated mechanisms and thyroid carcinoma. Crit Rev Clin Lab Sci; 2009;46(5-6):302-18
Hazardous Substances Data Bank. IODINE, ELEMENTAL .

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  • [Title] Iodine mediated mechanisms and thyroid carcinoma.
  • Iodine is a key element in the synthesis of thyroid hormones and the process of iodine transport by thyroid cells is active.
  • Iodine deficiency, which is a known risk factor for thyroid cancer, may result from inadequate dietary iodine or from defects in iodine transportation.
  • In contrast, a sufficient supply of iodine can induce cell-cycle arrest and apoptosis in thyroid cancer cells and may prevent the transformation of a differentiated thyroid cancer into a less differentiated or anaplastic form.
  • However, the functions of iodine are complex, and the mechanisms of its action in thyroid cancer are unclear.
  • This review focuses on the role of iodine in the carcinogenesis, proliferation, and apoptosis of thyroid cancers as well as on iodine transporters, most of which are impaired in thyroid cancer.
  • Elucidating the roles of iodine may generate novel diagnostic and therapeutic approaches to thyroid cancer and improve current strategies for its treatment and prevention.
  • [MeSH-major] Adenocarcinoma / metabolism. Iodine / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Apoptosis / drug effects. Cell Proliferation / drug effects. Cells, Cultured. Gene Expression Regulation, Neoplastic. Humans. Symporters / genetics. Symporters / metabolism. Thyroid Gland / metabolism

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  • (PMID = 19958216.001).
  • [ISSN] 1549-781X
  • [Journal-full-title] Critical reviews in clinical laboratory sciences
  • [ISO-abbreviation] Crit Rev Clin Lab Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Symporters; 0 / sodium-iodide symporter; 9679TC07X4 / Iodine
  • [Number-of-references] 237
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94. Haghpanah V, Abbas SI, Mahmoodzadeh H, Shojaei A, Soleimani A, Larijani B, Tavangar SM: Paraplegia as initial presentation of follicular thyroid carcinoma. J Coll Physicians Surg Pak; 2006 Mar;16(3):233-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraplegia as initial presentation of follicular thyroid carcinoma.
  • Follicular thyroid carcinoma with metastasis rarely presents with clinical picture of spinal cord compression.
  • This report describes a 53 years old patient with follicular thyroid carcinoma who presented with paraplegia and urinary incontinence.
  • Histopathology study demonstrated metastatic carcinoma of thyroid.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / secondary. Cervical Vertebrae. Paraplegia / etiology. Spinal Neoplasms / complications. Spinal Neoplasms / secondary. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Follow-Up Studies. Humans. Laminectomy. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Cord Compression / etiology. Spinal Cord Compression / surgery. Thyroid Gland / pathology. Thyroidectomy. Tomography, X-Ray Computed. Urinary Incontinence / etiology

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  • (PMID = 16542610.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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95. Haynik DM, Prayson RA: Immunohistochemical expression of Bcl-2, Bcl-x, and Bax in follicular carcinomas of the thyroid. Appl Immunohistochem Mol Morphol; 2006 Dec;14(4):417-21
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  • [Title] Immunohistochemical expression of Bcl-2, Bcl-x, and Bax in follicular carcinomas of the thyroid.
  • There is limited data on the expression of these proteins in follicular carcinomas (FCs) of the thyroid.
  • Normal thyroid tissue stained positively for bcl-2 and bcl-x, and did not stain with bax.
  • Aberrant expression of apoptosis-associated proteins may play a role in the pathogenesis of FC of the thyroid.

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  • (PMID = 17122638.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein; 0 / bcl-X Protein
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96. Gülben K, Berberoğlu U, Celen O, Mersin HH: Incidental papillary microcarcinoma of the thyroid--factors affecting lymph node metastasis. Langenbecks Arch Surg; 2008 Jan;393(1):25-9
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  • [Title] Incidental papillary microcarcinoma of the thyroid--factors affecting lymph node metastasis.
  • BACKGROUND AND AIMS: Despite the overall excellent prognosis for patients with thyroid papillary microcarcinoma (PMC), these tumors are associated with lymph node metastasis.
  • The aim of this study is to identify the rate of lymph node metastasis and evaluate the clinical and pathological factors affecting metastasis in thyroid PMC.
  • METHODS: Among 475 patients with papillary thyroid carcinoma treated between 1990 and 2003, 81 patients (17%) were diagnosed as PMC and the records of these patients were evaluated retrospectively.
  • Both multifocality and thyroid capsular invasion were found to be independent risk factors for lymph node metastasis by multivariate analysis.
  • CONCLUSION: Patients with thyroid PMC in low-risk group with multifocal tumors and with capsule invasion may have increased risk of lymph node metastasis, and must be considered in follow-up of the patients who have these factors.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Carcinoma, Papillary, Follicular / pathology. Incidental Findings. Lymphatic Metastasis / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lymph Nodes / pathology. Male. Middle Aged. Neck Dissection. Neoplasm Invasiveness. Neoplasms, Multiple Primary / mortality. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Prognosis. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Risk Factors. Thyroid Gland / pathology. Thyroidectomy. Young Adult

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  • (PMID = 17690905.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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97. Ouyang D, Chen FJ, Wei MW, Yang AK, Chen ZQ, Li QL, Chen YF: [Expression and clinical significance of galectin-3 in well-differentiated thyroid carcinoma]. Ai Zheng; 2005 Nov;24(11):1367-71
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  • [Title] [Expression and clinical significance of galectin-3 in well-differentiated thyroid carcinoma].
  • BACKGROUND & OBJECTIVE: The most challenging problem in diagnosing thyroid nodules is to distinguish benign disease from malignant disease.
  • Therefore, this study was designed to search for biological markers which can distinguish benign lesion from malignant lesion of thyroid.
  • METHODS: The expression of galectin-3 in 30 specimens of thyroid cancer, 10 specimens of thyroid adenoma, and 10 specimens of nodular thyroid goiter were detected by LSAB immunocytochemistry.
  • The results of routine pathologic examination of gland species were set as golden standard.
  • Galectin-3 was commonly expressed in well-differentiated thyroid carcinoma, but didn't express in thyroid adenoma and nodular thyroid goiter.
  • CONCLUSIONS: Galectin-3 is commonly expressed in thyroid malignant lesions, but not in benign lesions.
  • Immunocytochemistry assay can distinguish well-differentiated thyroid carcinoma from thyroid adnoma and nodular thyroid goiter.
  • [MeSH-major] Galectin 3 / metabolism. Thyroid Neoplasms / metabolism. Thyroid Nodule / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Adenoma / metabolism. Adenoma / pathology. Biopsy, Fine-Needle. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Gene Expression Regulation, Neoplastic. Goiter, Nodular / metabolism. Goiter, Nodular / pathology. Humans. Immunohistochemistry. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 16552965.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Galectin 3
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98. Kumar A, Nadig M, Patra V, Srivastava DN, Verma K, Bal CS: Adrenal and renal metastases from follicular thyroid cancer. Br J Radiol; 2005 Nov;78(935):1038-41
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  • [Title] Adrenal and renal metastases from follicular thyroid cancer.
  • Patients with differentiated thyroid cancer may have asymptomatic involvement of renal and/or adrenal gland, particularly if they are elderly and have associated metastases to other organs, which may remain undetected if these patients are not subjected to radioiodine treatment.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Adrenal Gland Neoplasms / secondary. Kidney Neoplasms / secondary. Thyroid Neoplasms / surgery


99. Rubaltelli L, Corradin S, Dorigo A, Stabilito M, Tregnaghi A, Borsato S, Stramare R: Differential diagnosis of benign and malignant thyroid nodules at elastosonography. Ultraschall Med; 2009 Apr;30(2):175-9
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  • [Title] Differential diagnosis of benign and malignant thyroid nodules at elastosonography.
  • PURPOSE: Ultrasound of the neck detects a large number of non-palpable thyroid nodules in the population, but it offers poor diagnostic accuracy (the presence of microcalcifications is the only statistically significant criterion indicative of malignancy).
  • The aim of this study is to evaluate elastography, a technique which allows differentiation between pathological and normal tissue by determining its hardness and which could also prove useful in the characterisation of thyroid nodules.
  • MATERIALS AND METHODS: In this prospective study, 51 thyroid nodules in 40 consecutive patients were examined (25 women, 15 men, mean age +/- SD, 54 +/- 13.4).
  • Only in two cases ultrasound demonstrated signs useful for a differential diagnosis (intrinsic microcalcifications).
  • CONCLUSION: Elastosonography provides an interesting contribution to the differentiation of malignant and benign thyroid nodules.
  • [MeSH-major] Elasticity Imaging Techniques / methods. Image Processing, Computer-Assisted. Thyroid Neoplasms / ultrasonography. Thyroid Nodule / ultrasonography. Ultrasonography, Doppler, Color / methods
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / surgery. Adenocarcinoma, Follicular / ultrasonography. Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / surgery. Adenocarcinoma, Papillary / ultrasonography. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Calcinosis / ultrasonography. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prospective Studies. Sensitivity and Specificity. Thyroid Gland / pathology. Thyroid Gland / ultrasonography. Thyroidectomy. Ultrasonography, Interventional. Young Adult

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  • (PMID = 18496776.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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100. Kuroda N, Hamauzu T, Toi M, Yamaoka K, Miyazaki E, Hiroi M, Nakata H, Taguchi H, Enzan H: Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report. APMIS; 2005 Jul-Aug;113(7-8):550-4
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  • [Title] Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report.
  • The tumor showed moderately differentiated papillary adenocarcinoma with a focal micropapillary component.
  • Carcinomatous lymphangiosis was also observed in the left lung and metastatic lesions were observed in the bilateral lung, liver, vertebra, muscle layer of the urinary bladder, right adrenal gland, spleen and lymph nodes.
  • Immunohistochemically, both the adenocarcinoma and micropapillary components were positive for cytokeratin (CK) 7, CK19, TTF (thyroid transcription factor)-1, carcinoembryonic antigen (CEA) and surfactant apoprotein A (SP-A), and negative for CK20, estrogen receptor, progesterone receptor, uroplakin III, and CA125.
  • The invasive area of the conventional adenocarcinoma component contained a large number of myofibroblasts, whereas the stroma of the micropapillary component contained a small number of myofibroblasts.
  • Myofibroblasts are present in the stroma of the invasive neoplastic nests in the micropapillary component as well as the conventional adenocarcinoma component, and D2-40 monoclonal antibody may be useful for evaluating the lymphatic invasion of pulmonary micropapillary carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. Adenocarcinoma, Papillary / pathology. Lung Neoplasms / metabolism. Lung Neoplasms / pathology

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  • (PMID = 16086826.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Nuclear Proteins; 0 / Pulmonary Surfactant-Associated Protein A; 0 / Transcription Factors; 0 / thyroid nuclear factor 1; 68238-35-7 / Keratins
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