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Items 1 to 75 of about 75
1. Seki E, Aoyama K, Ueda M, Haga T, Nakazato Y, Iijima M, Kojima M, Tanaka R: Mucinous adenocarcinoma of the thymus: a case report. J Thorac Oncol; 2008 Aug;3(8):935-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous adenocarcinoma of the thymus: a case report.
  • A mucinous adenocarcinoma of the thymus is rare, and there is presently limited information on the clinical aspects of this uncommon type of tumor.
  • Histologically the tumor consisted of a mucinous adenocarcinoma with pleural dissemination.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Thymus Neoplasms / pathology

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  • (PMID = 18670316.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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2. Ait M'barek L, Ait Mouse H, Jaâfari A, Aboufatima R, Benharref A, Kamal M, Bénard J, El Abbadi N, Bensalah M, Gamouh A, Chait A, Dalal A, Zyad A: Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy. Braz J Med Biol Res; 2007 Nov;40(11):1537-44
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  • [Title] Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy.
  • The anti-tumor effect of the Moroccan endemic thyme (Thymus broussonettii) essential oil (EOT) was investigated in vitro using the human ovarian adenocarcinoma IGR-OV1 parental cell line OV1/P and its chemoresistant counterparts OV1/adriamycin (OV1/ADR), OV1/vincristine (OV1/VCR), and OV1/cisplatin (OV1/CDDP).


3. Feng L, Jia XB, Shi F, Chen Y: Identification of two polysaccharides from Prunella vulgaris L. and evaluation on their anti-lung adenocarcinoma activity. Molecules; 2010 Aug;15(8):5093-103
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  • [Title] Identification of two polysaccharides from Prunella vulgaris L. and evaluation on their anti-lung adenocarcinoma activity.
  • In order to evaluate polysaccharide P32's anti-lung adenocarcinoma activities and immunomodulation effects, a C57BL/6 mouse-Lewis lung carcinoma (LLC) model was established and investigated.
  • Our results showed that polysaccharides of PV had anti-lung cancer activity and could increase the thymus index and the spleen index in tumor-bearing mice, suggesting possible immunomodulation effects.
  • [MeSH-minor] Animals. Chromatography, Gas. Chromatography, High Pressure Liquid. Drug Screening Assays, Antitumor. Mice. Mice, Inbred C57BL. Molecular Weight. Phytotherapy. Reference Standards. Spectrophotometry, Ultraviolet. Spleen / drug effects. Spleen / pathology. Thymus Gland / drug effects. Thymus Gland / pathology. Time Factors

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  • (PMID = 20714287.001).
  • [ISSN] 1420-3049
  • [Journal-full-title] Molecules (Basel, Switzerland)
  • [ISO-abbreviation] Molecules
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Polysaccharides
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4. Takahashi F, Tsuta K, Matsuno Y, Takahashi K, Toba M, Sato K, Uekusa T, Izumi H, Nakamura K, Hirose S, Fukuchi Y: Adenocarcinoma of the thymus: mucinous subtype. Hum Pathol; 2005 Feb;36(2):219-23
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  • [Title] Adenocarcinoma of the thymus: mucinous subtype.
  • Primary thymic adenocarcinoma, mucinous subtype, is extremely rare with only one case reported to date.
  • We describe herein a case of thymic mucinous adenocarcinoma.
  • A 59-year-old man was identified to have an anterior mediastinal tumor and was diagnosed as mucinous adenocarcinoma.
  • Collectively, the diagnosis of the tumor was primary mucinous adenocarcinoma of the thymus.
  • We propose that the mucinous subtype should be recognized as one of the histopathological entities of thymic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Mediastinal Neoplasms / pathology. Thymus Neoplasms / pathology

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  • (PMID = 15754301.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRT7 protein, human; 0 / Keratin-7; 68238-35-7 / Keratins
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5. Yoshioka M, Ichiguchi O, Hirayama T, Sassa T, Kamio T: Radical excision of thymic adenocarcinoma with selective cerebral perfusion. Ann Thorac Surg; 2008 Apr;85(4):1427-9
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  • [Title] Radical excision of thymic adenocarcinoma with selective cerebral perfusion.
  • Most cases of thymic carcinoma have some invasion to neighboring organs when diagnosed, and it is generally difficult to completely remove.
  • We adopted selective cerebral perfusion as a cerebral protection and successfully performed resection of a thymic adenocarcinoma that involved the superior vena cava, left brachiocephalic vein, right brachiocephalic artery and vein, and left common carotid artery in a 47-year-old woman.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Brain Ischemia / prevention & control. Mediastinal Neoplasms / secondary. Thymus Neoplasms / pathology. Thymus Neoplasms / surgery

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  • (PMID = 18355543.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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6. Petrella F, Leo F, Veronesi G, Solli P, Borri A, Galetta D, Gasparri R, Lembo R, Radice D, Scanagatta P, Spaggiari L: "Salvage" surgery for primary mediastinal malignancies: is it worthwhile? J Thorac Oncol; 2008 Jan;3(1):53-8

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  • Eleven patients suffered from thymic tumors (eight thymomas, three thymic carcinoma) whereas 10 patients suffered from nonthymic tumors (one lung adenocarcinoma + thymoma, two mediastinal monophasic sinovial sarcoma, one mediastinal neuroendocrine tumor, one mediastinal teratoblastoma, one mediastinal disgerminoma, one Hodgkin's lymphoma, one mediastinal atypic carcinoid, two medullary thyroid carcinoma).
  • Thymic neoplasms had a better prognosis (1-, 3-, and 5-year survival was 100, 87.5, 87.5%, respectively) when compared with others (1-, 3-, and 5-year survival was 77.8, 53.3, 26.7%, respectively--logrank p = 0.0128).
  • Thymic tumors obtain the best results in term of long-term survival.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Dysgerminoma / pathology. Dysgerminoma / surgery. Female. Follow-Up Studies. Hodgkin Disease / pathology. Hodgkin Disease / surgery. Humans. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Male. Middle Aged. Morbidity. Mortality. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / surgery. Retrospective Studies. Salvage Therapy / methods. Sarcoma / pathology. Sarcoma / surgery. Survival Analysis. Teratoma / pathology. Teratoma / surgery. Thymoma / pathology. Thymoma / surgery. Thymus Neoplasms / pathology. Thymus Neoplasms / surgery. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery. Time Factors. Treatment Outcome

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  • (PMID = 18166841.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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7. Beckford FA, Shaloski M Jr, Leblanc G, Thessing J, Lewis-Alleyne LC, Holder AA, Li L, Seeram NP: Microwave synthesis of mixed ligand diimine-thiosemicarbazone complexes of ruthenium(II): biophysical reactivity and cytotoxicity. Dalton Trans; 2009 Dec 28;(48):10757-64
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  • Fluorescence competition studies with ethidium bromide, along with viscometric measurements suggests that the complexes bind calf thymus DNA (CTDNA) relatively strongly via an intercalative mode possibly involving the aromatic rings of the diimine ligands.
  • The complexes show good cytotoxic profiles against MCF-7 and MDA-MB-231 (breast adenocarcinoma) as well as HCT 116 and HT-29 (colorectal carcinoma) cell lines.

  • Hazardous Substances Data Bank. 2,2'-BIPYRIDINE .
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  • (PMID = 20023905.001).
  • [ISSN] 1477-9234
  • [Journal-full-title] Dalton transactions (Cambridge, England : 2003)
  • [ISO-abbreviation] Dalton Trans
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR016460; United States / NCRR NIH HHS / RR / P20 RR016460-02; United States / NCRR NIH HHS / RR / P20 RR-16460
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthracenes; 0 / Antineoplastic Agents; 0 / Coordination Complexes; 0 / Imines; 0 / Ligands; 0 / Phenanthrolines; 0 / Thiosemicarbazones; 551W113ZEP / 2,2'-Dipyridyl; 642-31-9 / 9-anthraldehyde; 7UI0TKC3U5 / Ruthenium; 9007-49-2 / DNA; 91080-16-9 / calf thymus DNA; W4X6ZO7939 / 1,10-phenanthroline
  • [Other-IDs] NLM/ NIHMS167903; NLM/ PMC2814159
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8. Godlewska J, Luniewski W, Zagrodzki B, Kaczmarek L, Bielawska-Pohl A, Dus D, Wietrzyk J, Opolski A, Siwko M, Jaromin A, Jakubiak A, Kozubek A, Peczyñska-Czoch W: Biological evaluation of omega-(dialkylamino)alkyl derivatives of 6H-indolo[2,3-b]quinoline--novel cytotoxic DNA topoisomerase II inhibitors. Anticancer Res; 2005 Jul-Aug;25(4):2857-68
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  • Liphophilic and calf thymus DNA-binding properties of these compounds were also investigated.
  • They also showed cytotoxic activity against KB (human cervix carcinoma) cells (ID50 varied from 2.1 to 9.0 microM) and were able to overcome multidrug resistance in colorectal adenocarcinoma LoVo/DX, uterine sarcoma MES-SA/DX5 and promyelocytic leukemia HL-60/MX2 cells (the values of the resistance index RI fell between 0.54 and 2.4).

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  • (PMID = 16080538.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Alkaloids; 0 / Antineoplastic Agents, Phytogenic; 0 / DNA Adducts; 0 / Indoles; 0 / Quinolines; 0 / Topoisomerase II Inhibitors; 9007-49-2 / DNA; 91080-16-9 / calf thymus DNA
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9. Ishiwata T, Sekiya M, Suzuki T, Matsuoka T, Kumasaka T, Takahashi K: Thymic adenocarcinoma with sarcomatoid features characterized by intracaval tumor growth: report of a case. Surg Today; 2010 Nov;40(11):1068-72
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  • [Title] Thymic adenocarcinoma with sarcomatoid features characterized by intracaval tumor growth: report of a case.
  • Primary thymic adenocarcinoma is an extremely rare tumor.
  • This report describes a case of thymic adenocarcinoma with a peculiar pathological feature and clinical course.
  • The histological findings revealed the tumor to be an adenocarcinoma with sarcomatous features.
  • These results suggested the tumor to be a thymic adenocarcinoma with sarcomatoid features; furthermore, the tumor invaded the great vessels, thus resulting in a poor prognosis.
  • [MeSH-major] Adenocarcinoma / pathology. Sarcoma / pathology. Thymoma / pathology. Thymus Neoplasms / pathology. Vena Cava, Superior / pathology

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  • (PMID = 21046507.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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10. Ra YJ, Bae MJ, Kim YS, Choi KU: Difficulties in diagnosis and treatment of thymic adenocarcinoma producing beta-human chorionic gonadotropin in anterior mediastinum. Interact Cardiovasc Thorac Surg; 2010 Jul;11(1):114-6
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  • [Title] Difficulties in diagnosis and treatment of thymic adenocarcinoma producing beta-human chorionic gonadotropin in anterior mediastinum.
  • On the pathological examination after the second operation, the tumor was diagnosed as thymic adenocarcinoma producing beta-hCG, and the tumor had originated from the thymus.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Biomarkers, Tumor / blood. Chorionic Gonadotropin, beta Subunit, Human / blood. Mediastinal Neoplasms / secondary. Mediastinal Neoplasms / surgery. Thoracic Surgical Procedures. Thymus Neoplasms / pathology. Thymus Neoplasms / surgery

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  • (PMID = 20421278.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
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11. Sawai T, Inoue Y, Doi S, Ikuta Y, Kimino K, Nakashima M, Soda H, Kohno S: Tubular adenocarcinoma of the thymus: case report and review of the literature. Int J Surg Pathol; 2006 Jul;14(3):243-6
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  • [Title] Tubular adenocarcinoma of the thymus: case report and review of the literature.
  • Primary carcinomas of the thymus are rare.
  • Adenocarcinomas of the thymus are extremely rare.
  • As determined from a literature search, a pure tubular adenocarcinoma has never been previously described, and thus, this is first case report of tubular adenocarcinoma of the thymus.
  • [MeSH-major] Adenocarcinoma / pathology. Thymus Neoplasms / pathology

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  • (PMID = 16959713.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen
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12. Hosaka Y, Tsuchida M, Umezu H, Eimoto T, Hashimoto T, Shinohara H, Hayashi J: Primary thymic adenocarcinoma coexisting with type AB thymoma: a rare case with long-term survival. Gen Thorac Cardiovasc Surg; 2010 Sep;58(9):488-91; discussion 491-2
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  • [Title] Primary thymic adenocarcinoma coexisting with type AB thymoma: a rare case with long-term survival.
  • Thymic carcinoma is a rare tumor.
  • The most common histological subtype is squamous cell carcinoma, and only a few cases of thymic adenocarcinoma have been reported.
  • A case of papillary adenocarcinoma of thymic origin that coexisted with type AB thymoma as a separate nodule is presented herein.
  • On pathological examination, two tumors, which were diagnosed as papillary adenocarcinoma and type AB thymoma, respectively, were present in the thymus without any connection with each other.
  • We diagnosed the adenocarcinoma in this case was a primary thymic carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / complications. Thymoma / complications. Thymus Neoplasms / complications

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  • [Cites] Am J Surg Pathol. 2003 Jan;27(1):124-30 [12502935.001]
  • [Cites] Int J Surg Pathol. 2006 Jul;14(3):243-6 [16959713.001]
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  • (PMID = 20859731.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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13. Furtado A, Nogueira R, Ferreira D, Tente D, Eisele R, Parente B: Papillary adenocarcinoma of the thymus: case report and review of the literature. Int J Surg Pathol; 2010 Dec;18(6):530-3
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  • [Title] Papillary adenocarcinoma of the thymus: case report and review of the literature.
  • A 44-year-old male with a mediastinal mass measuring 3.5 × 3.5 × 3 cm was diagnosed with papillary adenocarcinoma of the thymus.
  • Other origins of papillary adenocarcinoma were excluded by clinical, imaging, and immunocytochemical methods before assuming this diagnosis.
  • Residual thymus was seen under the microscope.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Thymus Neoplasms / pathology

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  • (PMID = 18611939.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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14. Kapur P, Rakheja D, Bastasch M, Molberg KH, Sarode VR: Primary mucinous adenocarcinoma of the thymus: a case report and review of the literature. Arch Pathol Lab Med; 2006 Feb;130(2):201-4
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  • [Title] Primary mucinous adenocarcinoma of the thymus: a case report and review of the literature.
  • Primary thymic mucinous adenocarcinoma is extremely rare; to our knowledge, only 2 cases have been reported to date.
  • We describe a third case of primary mucinous adenocarcinoma of the thymus in a 41-year-old man who presented with an anterior mediastinal mass with subsequent metastasis to the lung.
  • The initial diagnosis was of metastatic mucinous adenocarcinoma, but extensive clinical workup of the patient failed to reveal a primary tumor elsewhere in the body.
  • The specific identification of mucinous adenocarcinoma as a primary thymic neoplasm can be difficult or impossible.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Thymus Neoplasms / pathology

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  • (PMID = 16454563.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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15. Maeda D, Ota S, Ikeda S, Kawano R, Hata E, Nakajima J, Mori M, Fukayama M: Mucinous adenocarcinoma of the thymus: a distinct variant of thymic carcinoma. Lung Cancer; 2009 Apr;64(1):22-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous adenocarcinoma of the thymus: a distinct variant of thymic carcinoma.
  • BACKGROUND: Primary thymic mucinous adenocarcinoma is a recently described subtype of thymic carcinoma, which behaves aggressively.
  • METHODS: The authors analyzed the clinical and pathological findings of three cases of thymic mucinous adenocarcinoma, and reviewed five cases previously reported in the English literature.
  • In one case, associated thymic cysts were found at the periphery of the tumor.
  • The cyst wall was partially lined by malignant mucinous epithelium, which showed transition from benign thymic epithelium.
  • CONCLUSION: Growing evidence suggests that mucinous adenocarcinoma is a distinct morphological variant of primary thymic carcinoma.
  • We believe that clinicians and surgical pathologists should include thymic mucinous adenocarcinoma in the differential diagnosis of mediastinal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Thymoma / pathology. Thymus Neoplasms / pathology

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  • (PMID = 18722686.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Keratin-20
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16. Yoshino M, Hiroshima K, Motohashi S, Shibuya K, Iyoda A, Sekine Y, Fujisawa T: Papillary carcinoma of the thymus gland. Ann Thorac Surg; 2005 Aug;80(2):741-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary carcinoma of the thymus gland.
  • In 1999, the World Health Organization introduced a new classification of a rare thymic cancer called papillary adenocarcinoma of the thymus gland.
  • In this study we report on a case of papillary thymic carcinoma in a 29-year-old woman.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Thymus Neoplasms / pathology

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  • (PMID = 16039252.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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17. Carvalho S, Branco R, Serralheiro P, Saraiva T, Carvalho L: [Lung adenocarcinoma: application of the WHO 1999/2004 classification to the caseload of the Pathologic Anatomy Service at the Hospital of the Coimbra University]. Rev Port Pneumol; 2006 May-Jun;12(3):255-68
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lung adenocarcinoma: application of the WHO 1999/2004 classification to the caseload of the Pathologic Anatomy Service at the Hospital of the Coimbra University].
  • [Transliterated title] Adenocarcinoma do pulmão: Aplicação da classificação WHO 1999/2004 à casuística do Serviço de Anatomia Patológica do Hospital da Universidade de Coimbra.
  • The criteria defined by the WHO classification of Tumours of the Lung, Pleura, Thymus and Heart 2004 were applied to the primary adenocarcinomas of the lung and as was expected, bronchioloalveolar carcinomas had its incidence in women while acinar adenocarcinomas were diagnosed mainly in men.
  • A number of 109 cases had the final diagnosis of adenocarcinoma of the lung based on morphology and immunohistochemistry criteria.
  • [MeSH-major] Adenocarcinoma / classification. Adenocarcinoma / pathology. International Classification of Diseases. Lung Neoplasms / classification. Lung Neoplasms / pathology

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  • (PMID = 16967175.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Portugal
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18. Srirajaskanthan R, Toubanakis C, Dusmet M, Caplin ME: A review of thymic tumours. Lung Cancer; 2008 Apr;60(1):4-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A review of thymic tumours.
  • Tumours of the thymus are uncommon and are generally regarded as being indolent.
  • Whilst this is often true of thymomas; thymic adenocarcinoma and thymic neuroendocrine cancer can be aggressive and have a poor prognosis.
  • The role for adjuvant therapy in both thymic carcinoma and thymoma is unclear except, in patients with stage I thymomas.
  • There is a high expression of somatostatin receptors in thymic tumours and anti-tumour benefit has been reported in patients treated with somatostatin analogues.
  • This has become an established therapy in management of gastroenteropancreatic neuroendocrine tumours and its use has been recently described in case reports in both thymoma and thymic carcinoma.
  • [MeSH-major] Thymus Neoplasms / therapy

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  • (PMID = 18343528.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 88
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19. Okuda M, Huang CL, Haba R, Yokomise H: Clear cell carcinoma originating from ectopic thymus. Gen Thorac Cardiovasc Surg; 2009 May;57(5):269-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell carcinoma originating from ectopic thymus.
  • Ectopic thymus is not uncommon, but clear cell carcinoma originating from ectopic thymus has never been reported.
  • We report a case of clear cell carcinoma originating from ectopic thymus in which there was a good response to steroid-supplemented chemoradiotherapy.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Choristoma / pathology. Mediastinal Neoplasms / pathology. Thymus Gland

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  • [Cites] Int J Pediatr Otorhinolaryngol. 1999 Jan 25;47(1):29-39 [10206392.001]
  • [Cites] Cancer. 1991 Feb 15;67(4):1025-32 [1991250.001]
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  • (PMID = 19440827.001).
  • [ISSN] 1863-6705
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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20. Kubota Y, Chihara Y, Date K, Yamada T, Hara H: [Case of thymic carcinoid accompanied by adenocarcinoma of the lung]. Nihon Kokyuki Gakkai Zasshi; 2010 Dec;48(12):950-4
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case of thymic carcinoid accompanied by adenocarcinoma of the lung].
  • The rapid intraoperative pathological diagnosis was adenocarcinoma from the lung nodules and low grade malignancy from an anterior mediastinal tumor.
  • Postoperative pathological examination revealed the coexistence of lung cancer and a typical carcinoid of the thymus.
  • To the best of our knowledge, we report the first case of thymic carcinoid accompanied with adenocarcinoma of the lung.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoid Tumor / diagnosis. Lung Neoplasms / diagnosis. Mediastinal Neoplasms / diagnosis. Neoplasms, Multiple Primary. Thymus Neoplasms / diagnosis

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  • (PMID = 21226303.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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21. Montella L, Caraglia M, Abbruzzese A, Soricelli A, Caputi M, Squame G, Salvatore M, Del Prete S, Palmieri G: Mediastinal images resembling thymus following 131-I treatment for thyroid cancer. Monaldi Arch Chest Dis; 2005 Jun;63(2):114-7
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal images resembling thymus following 131-I treatment for thyroid cancer.
  • Among them, mediastinal uptake caused by thymic hyperplasia can be observed.
  • The aim of the present study was to review a series of 573 patients with differentiated thyroid cancer treated with 131-I after surgery between 1992 and 2003 looking above all for those with mediastinal images resembling thymus.
  • This evaluation is presented together with some hypotheses on the relationships between thymus and thyroid.
  • Moreover, some considerations are made on the differential diagnosis between thymus and mediastinal tumour thyroid residues.

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  • (PMID = 16128228.001).
  • [ISSN] 1122-0643
  • [Journal-full-title] Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
  • [ISO-abbreviation] Monaldi Arch Chest Dis
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals
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22. Morikawa H, Tanaka T, Hamaji M, Ueno Y, Hara A: Papillary adenocarcinoma developed in a thymic cyst. Gen Thorac Cardiovasc Surg; 2010 Jun;58(6):295-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary adenocarcinoma developed in a thymic cyst.
  • In this report, we describe a case of a thymic carcinoma that developed in a thymic cyst, which was resected by video-assisted thoracic surgery (VATS).
  • Based on these findings, a thymic cyst was suspected.
  • Microscopic examination revealed that the nodular excrescence of the wall to be limited to papillary adenocarcinoma and the cyst wall to be lined by cuboidal cells.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Mediastinal Cyst / pathology. Thymus Neoplasms / pathology

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  • [Cites] J Surg Oncol. 1994 Dec;57(4):277-9 [7990487.001]
  • [Cites] Jpn J Thorac Cardiovasc Surg. 1998 Nov;46(11):1168-71 [9884571.001]
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  • (PMID = 20549461.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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23. Noriyuki T, Hamamoto M, Takazawa Y, Katoh K, Hashimoto M, Kuranishi F, Nakahara M, Fukuda T, Ishizaki Y, Okuda H, Akimoto E, Yonehara S: [Thymic carcinoma involving aortic arch; report of a case]. Kyobu Geka; 2009 May;62(5):417-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Thymic carcinoma involving aortic arch; report of a case].
  • Adenocarcinoma of the thymus is a very rare malignant tumor.
  • The standard treatment for advanced thymic carcinoma has not yet been established, and the prognosis is poor.
  • We report a case of thymic carcinoma that involving the aortic arch and the innominate vein.
  • Microspcopic examinations of specimens obtained by CT-guided needle biopsy revealed poorly differenciated adenocarcinoma.
  • Thymic carcinoma was diagnosed.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Aorta, Thoracic / pathology. Thymus Neoplasms / pathology. Thymus Neoplasms / surgery

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  • (PMID = 19425386.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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24. Ra SH, Fishbein MC, Baruch-Oren T, Shintaku P, Apple SK, Cameron RB, Lai CK: Mucinous adenocarcinomas of the thymus: report of 2 cases and review of the literature. Am J Surg Pathol; 2007 Sep;31(9):1330-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous adenocarcinomas of the thymus: report of 2 cases and review of the literature.
  • Primary thymic adenocarcinomas are extremely rare neoplasms.
  • The second case in an 82-year-old woman was a mucinous adenocarcinoma arising from a thymic cyst with areas of transition from benign to dysplastic epithelium.
  • The tumor cells formed dilated glands, cords, and small nests that infiltrated the thymic cyst wall and exhibited evidence of mucin production.
  • CONCLUSIONS: Mucinous adenocarcinoma, with or without, psammoma bodies, may be of primary thymic origin and should be considered in the differential diagnosis of malignant mediastinal tumors.
  • These 2 cases provide further documentation of the rare occurrence of primary mucinous adenocarcinomas of the thymic gland.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Mediastinal Neoplasms / diagnosis. Thymus Neoplasms / diagnosis

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  • (PMID = 17721187.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD5; 0 / KRT5 protein, human; 0 / KRT7 protein, human; 0 / Keratin-5; 0 / Keratin-6; 0 / Keratin-7
  • [Number-of-references] 18
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25. Damadi A, Harkema J, Kareti R, Saxe A: Use of pre-operative Tc99m-Sestamibi scintigraphy and intraoperative parathyroid hormone monitoring to eliminate neck exploration in mediastinal parathyroid adenocarcinoma. J Surg Educ; 2007 Mar-Apr;64(2):108-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of pre-operative Tc99m-Sestamibi scintigraphy and intraoperative parathyroid hormone monitoring to eliminate neck exploration in mediastinal parathyroid adenocarcinoma.
  • The mass was completely resected with surrounding thymus gland.
  • [MeSH-major] Adenocarcinoma / surgery. Monitoring, Intraoperative. Neck / surgery. Parathyroid Hormone / analysis. Parathyroid Neoplasms / surgery. Preoperative Care. Radiopharmaceuticals. Technetium Tc 99m Sestamibi

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  • (PMID = 17462212.001).
  • [ISSN] 1931-7204
  • [Journal-full-title] Journal of surgical education
  • [ISO-abbreviation] J Surg Educ
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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26. Li BL, Zhang GX, Hou XL, Tan MW, Yuan Y, Liu XH, Gong DJ, Huang SD: [Recombinant adeno-associated virus mediated RNA interference of angiogenin expression inhibits cell growth of human lung adenocarcinoma]. Zhonghua Jie He He Hu Xi Za Zhi; 2009 Mar;32(3):188-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recombinant adeno-associated virus mediated RNA interference of angiogenin expression inhibits cell growth of human lung adenocarcinoma].
  • In vivo experiment using thymus-defect mice showed that, there was an remarkable reduction in the mass and volume of tumors in AAV-shANG transfected group, compared to the control groups.
  • [MeSH-major] Adenocarcinoma / pathology. Lung Neoplasms / pathology. RNA Interference. Ribonuclease, Pancreatic / metabolism

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  • (PMID = 19575937.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.1.27.- / angiogenin; EC 3.1.27.5 / Ribonuclease, Pancreatic
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27. Morresi-Hauf A, Wöckel W, Kirchner T: [Thymic cyst with initial malignant transformation]. Pathologe; 2008 Jul;29(4):308-10
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Thymic cyst with initial malignant transformation].
  • We present the case of a 38-year-old woman with a thymus cyst with an incidental tiny adenocarcinoma.
  • Adenocarcinomas and adenosquamous carcinomas of the thymus or in thymus cysts have seldom been reported.
  • Our case is the first report on an incipient adenocarcinoma in a thymus cyst.
  • It demonstrates the importance of thorough histological examination of cystic changes in the thymus, not only for the diagnostic classification of the lesion but also to ensure that a possible malignant change is not overlooked.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Adenosquamous / pathology. Cysts / pathology. Thymus Gland / pathology. Thymus Neoplasms / pathology

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  • [Cites] Histopathology. 2004 Jan;44(1):64-8 [14717671.001]
  • [Cites] J Surg Oncol. 1994 Dec;57(4):277-9 [7990487.001]
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  • (PMID = 18389237.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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28. Togashi K, Sato S, Sato K: [Lung metastasis of thymic carcinoma twelve years after complete resection of primary disease]. Kyobu Geka; 2009 Dec;62(13):1150-3
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lung metastasis of thymic carcinoma twelve years after complete resection of primary disease].
  • 12 years later, she was diagnosed as having primary lung adenocarcinoma with bronchoscopic examination and cytology.
  • Postoperative histological and immunohistochemical examination showed that the lung nodule was a lymphoepithelioma-like carcinoma of the thymus with strong immunoreactivity for CD5 and bcl-2.
  • Reexamination by immunohistochemical staining for CD5 and bcl-2 revealed that the disease diagnosed as thymoma 12 years ago was also thymic carcinoma Accurate differential diagnosis between B3-thymoma and thymic carcinoma is essential for choosing appropriate postoperative treatment.
  • [MeSH-major] Adenocarcinoma / pathology. Lung Neoplasms / secondary. Thymoma / pathology. Thymus Neoplasms / pathology

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  • (PMID = 19999093.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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29. Moorjani N, Khan O, Brown I, Singh N, Amer K: Synchronous thymoma and lung carcinoma resected via median sternotomy with VATS guidance. Thorac Cardiovasc Surg; 2007 Jun;55(4):271-2
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Synchronous tumours of the thymus and lung are rare.
  • We describe the case of a 57-year-old gentleman, who presented with a large type AB thymoma in the superior anterior mediastinum and a primary bronchogenic adenocarcinoma in the right upper lobe.
  • [MeSH-major] Adenocarcinoma / surgery. Lung Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Thoracic Surgery, Video-Assisted. Thymoma / surgery. Thymus Neoplasms / surgery

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  • (PMID = 17546563.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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30. Rizzati V, Rathahao E, Gamet-Payrastre L, Delous G, Jouanin I, Guéraud F, Paris A: In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids; 2005 Mar;70(3):161-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • First, using a human kidney adenocarcinoma cell line, which expresses specifically the cytochrome P4501B1, we showed that estradiol-17alpha is bioactivated into a mixture of 2- and 4-catechol estrogens leading to the corresponding methoxyestrogens unambiguously identified by LC-APCI-MS/MS.
  • We then demonstrated that the 2- and 4-hydroxylated derivatives of estradiol-17alpha incubated under oxidative conditions with calf thymus DNA gave stable DNA adducts and abasic sites, respectively.
  • [MeSH-minor] Adenocarcinoma / metabolism. Animals. Catechols / metabolism. Cattle. Cell Line, Tumor. Chromatography, High Pressure Liquid. Chromatography, Liquid. Chromatography, Thin Layer. DNA / metabolism. Estrogens / chemistry. Estrogens, Catechol / chemistry. Humans. Hydroxyestrones / chemistry. Hydroxylation. In Vitro Techniques. Kidney Neoplasms / metabolism. Mass Spectrometry. Oxygen / metabolism. Thymus Gland / metabolism. Time Factors

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  • (PMID = 15763594.001).
  • [ISSN] 0039-128X
  • [Journal-full-title] Steroids
  • [ISO-abbreviation] Steroids
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Catechols; 0 / DNA Adducts; 0 / Estrogens; 0 / Estrogens, Catechol; 0 / Hydroxyestrones; 4TI98Z838E / Estradiol; 9007-49-2 / DNA; S88TT14065 / Oxygen
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31. Wang HF, Shen R, Tang N: Synthesis and characterization of the Zn(II) and Cu(II) piperidinyl isoeuxanthone complexes: DNA-binding and cytotoxic activity. Eur J Med Chem; 2009 Nov;44(11):4509-15
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  • Their interactions with calf thymus DNA (ct DNA) were investigated by absorption spectroscopy, fluorescence spectroscopy, ethidium bromide (EB) displacement experiments, circular dichroism spectroscopy and viscosity measurements.
  • In addition, the cytotoxic effects of both complexes were evaluated with lung adenocarcinoma (GLC-82), esophagus squamous cancer (ECA109) and human gastric cancer (SGC7901) cells using MTT assay.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Animals. Carcinoma, Squamous Cell / drug therapy. Cattle. Cell Line, Tumor. Cell Survival / drug effects. Drug Screening Assays, Antitumor. Esophageal Neoplasms / drug therapy. Humans. Lung Neoplasms / drug therapy. Spectroscopy, Near-Infrared. Stomach Neoplasms / drug therapy. Viscosity

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  • (PMID = 19604605.001).
  • [ISSN] 1768-3254
  • [Journal-full-title] European journal of medicinal chemistry
  • [ISO-abbreviation] Eur J Med Chem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Xanthones; 789U1901C5 / Copper; 9007-49-2 / DNA; 91080-16-9 / calf thymus DNA; 9749WEV0CA / xanthone; J41CSQ7QDS / Zinc
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32. Gao Z, Kahn L, Bhuiya T: Thymic carcinoid with mucinous stroma: a rare variant of carcinoid with an aggressive clinical course. Ann Diagn Pathol; 2006 Apr;10(2):114-6
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  • [Title] Thymic carcinoid with mucinous stroma: a rare variant of carcinoid with an aggressive clinical course.
  • One variant of thymic carcinoid has prominent mucinous stroma first reported in 1995.
  • We describe such a case characterized by abundant stromal mucin resulting in a histologic picture resembling of metastatic mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Carcinoid Tumor / pathology. Mediastinal Neoplasms / pathology. Mucins / metabolism. Thymus Neoplasms / pathology

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  • (PMID = 16546049.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
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33. O'Donoghue K, Sultan HA, Al-Allaf FA, Anderson JR, Wyatt-Ashmead J, Fisk NM: Microchimeric fetal cells cluster at sites of tissue injury in lung decades after pregnancy. Reprod Biomed Online; 2008 Mar;16(3):382-90
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  • Male cells were identified in lung/thymus tissue from all women with known male pregnancies, but not in those without sons.
  • The frequency of male microchimeric cells was seven-fold greater in lung/thymus tissues than marrow and was two-fold greater than normal bone from the same women.
  • [MeSH-major] Adenocarcinoma / pathology. Chimerism. Fetal Stem Cells / pathology. Lung / pathology. Lung Neoplasms / pathology. Wound Healing / physiology
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / pathology. Choristoma / pathology. Female. Fibroma / pathology. Humans. Male. Middle Aged. Pleural Neoplasms / pathology. Pregnancy. Thymus Neoplasms / pathology

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  • (PMID = 18339261.001).
  • [ISSN] 1472-6483
  • [Journal-full-title] Reproductive biomedicine online
  • [ISO-abbreviation] Reprod. Biomed. Online
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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34. Tsuchida M, Umezu H, Hashimoto T, Shinohara H, Koike T, Hosaka Y, Eimoto T, Hayashi JI: Absence of gene mutations in KIT-positive thymic epithelial tumors. Lung Cancer; 2008 Dec;62(3):321-5
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  • [Title] Absence of gene mutations in KIT-positive thymic epithelial tumors.
  • However, the role of KIT expression in thymic carcinoma is not fully understood.
  • METHODS: Thymic epithelial tumors from 37 patients (17 thymic carcinomas and 20 thymomas) were examined.
  • RESULTS: KIT- and CD5-positive staining was observed only in thymic carcinoma.
  • Mutation analysis of the KIT gene was performed in 11 squamous cell carcinomas, 1 adenocarcinoma and 1 adenosquamous cell carcinoma.
  • CONCLUSIONS: Squamous cell carcinoma of the thymus frequently expressed KIT and CD5 proteins, whereas other tumors did not.
  • Unlike GIST, overexpression of KIT does not necessarily indicate gene mutation in thymic carcinoma.
  • KIT and CD5 appear useful for evaluating and subtyping thymic epithelial tumors.
  • [MeSH-major] Adenocarcinoma / genetics. Carcinoma, Adenosquamous / genetics. Carcinoma, Squamous Cell / genetics. Mutation / genetics. Proto-Oncogene Proteins c-kit / genetics. Thymoma / genetics. Thymus Neoplasms / genetics

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  • (PMID = 18486988.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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35. Carrio R, Lopez DM: Impaired thymopoiesis occurring during the thymic involution of tumor-bearing mice is associated with a down-regulation of the antiapoptotic proteins Bcl-XL and A1. Int J Mol Med; 2009 Jan;23(1):89-98
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  • [Title] Impaired thymopoiesis occurring during the thymic involution of tumor-bearing mice is associated with a down-regulation of the antiapoptotic proteins Bcl-XL and A1.
  • The thymus is a central lymphoid organ in which T lymphocytes undergo differentiation and maturation without the need for antigenic stimulation.
  • Thymic atrophy has been observed in several model systems, including aging, graft-vs-host-disease and tumor development.
  • We have previously shown that the progressive growth of D1-DMBA-3 mammary tumor leads to extreme thymic atrophy in the host.
  • This thymic involution is associated with an early block in T cell maturation at the triple negative stage of differentiation.
  • In the present study we have used our murine mammary tumor model to further analyze the specific T cell subpopulations present in the thymus of tumor-bearing animals as well as to characterize the alterations of the apoptotic process present during the impaired thymopoiesis associated to this thymic involution.
  • Together, our data suggest that the severe thymic involution seen in mammary tumor bearers is due to an arrest in at least two steps of T cell differentiation and a down-regulation of important molecules that control programmed cell death.
  • [MeSH-major] Down-Regulation. Gene Expression Regulation, Neoplastic. Proto-Oncogene Proteins / genetics. Thymus Gland / immunology. bcl-X Protein / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / immunology. Animals. Apoptosis. Atrophy. Cell Dedifferentiation. Mammary Neoplasms, Experimental / genetics. Mammary Neoplasms, Experimental / immunology. Mice. Mice, Inbred BALB C. Proto-Oncogene Proteins c-bcl-2. T-Lymphocytes / cytology. T-Lymphocytes / immunology

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  • (PMID = 19082511.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA25583
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Bcl2l1 protein, mouse; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-X Protein; 114100-40-2 / Bcl2 protein, mouse
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36. Morton D, Bailey KL, Stout CL, Weaver RJ, White KA, Lorenzen MJ, Ball DJ: N-Methyl-N-Nitrosourea (MNU): A positive control chemical for p53+/- mouse carcinogenicity studies. Toxicol Pathol; 2008 Dec;36(7):926-31
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  • Twenty-four males and twenty-seven females treated with MNU developed malignant lymphoma of the thymus; of these, twenty-three males and twenty-seven females had corresponding enlargement or masses in the thymus at necropsy.
  • Lymphoblasts in thymic lymphomas stained positively for mouse CD3 antigen, indicating a T-cell lineage.
  • One control female mouse had malignant lymphoma of the spleen that did not involve the thymus.
  • These findings support the use of a single dose of MNU as a positive control chemical in six-month p53+/- mouse carcinogenicity studies and suggest that examination of the thymus alone is sufficient to evaluate the validity of the model system.
  • [MeSH-minor] Adenocarcinoma / chemically induced. Adenocarcinoma / pathology. Adenoma / chemically induced. Adenoma / pathology. Animals. Antigens, CD3 / metabolism. Duodenal Neoplasms / chemically induced. Duodenal Neoplasms / pathology. Female. Genes, p53. Heterozygote. Injections, Intraperitoneal. Intestine, Small / pathology. Jejunal Neoplasms / chemically induced. Jejunal Neoplasms / pathology. Lymphoma / chemically induced. Lymphoma / pathology. Male. Mice. Mice, Knockout. Thymus Gland / pathology. Thymus Neoplasms / chemically induced. Thymus Neoplasms / pathology

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  • (PMID = 18827072.001).
  • [ISSN] 1533-1601
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Carcinogens; 684-93-5 / Methylnitrosourea
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37. Choi JJ, Ahn MI, Park MY, Jeon JS, Park YH: F-18 FDG PET/CT demonstration of thymoma followed by development of lung cancer. Clin Nucl Med; 2008 Mar;33(3):234-5
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  • The FDG uptake in the lung nodule was significantly higher than that of the thymic lesion, which might suggest the possibility of a second development of lung cancer in this thymoma patient.
  • Surgical resection was done for the 2 tumors, and histologic examination revealed anterior mediastinal thymoma and primary adenocarcinoma of the lung.
  • [MeSH-major] Adenocarcinoma / radiography. Adenocarcinoma / radionuclide imaging. Lung Neoplasms / secondary. Thymoma / radiography. Thymoma / radionuclide imaging. Thymus Neoplasms / radiography. Thymus Neoplasms / radionuclide imaging

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  • (PMID = 18287859.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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38. Kuriyama S, Ohashi R, Matsuda K, Sugano K, Muraki K, Minakata K, Ishiwata T, Hirama M, Kodama Y, Oh S, Suzuki K, Takahashi K: [Twelve cases of advanced thymic carcinoma: a clinical review]. Nihon Kokyuki Gakkai Zasshi; 2010 Aug;48(8):604-8
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  • [Title] [Twelve cases of advanced thymic carcinoma: a clinical review].
  • Thymic carcinoma is comparatively rare and no standard treatment has been established for advanced stage cases.
  • We reviewed our therapeutic experience in 12 cases of thymic carcinoma.
  • Nine cases were squamous cell carcinoma and 3 were adenocarcinoma.
  • The prognosis outcome of advanced thymic carcinoma is poor, but combined modality therapies such as surgery, chemotherapy and radiation can be effective for some advanced thymic carcinoma cases.
  • [MeSH-major] Adenocarcinoma / therapy. Carcinoma, Squamous Cell / therapy. Thymus Neoplasms / therapy

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  • (PMID = 20803979.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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39. Toda M, Hisano R, Yurugi H, Akita K, Maruyama K, Inoue M, Adachi T, Tsubata T, Nakada H: Ligation of tumour-produced mucins to CD22 dramatically impairs splenic marginal zone B-cells. Biochem J; 2009 Feb 1;417(3):673-83

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  • Mouse mammary adenocarcinoma cells, TA3-Ha, produce a mucin named epiglycanin, but a subline of them, TA3-St, does not.
  • It should be noted that splenic MZ (marginal zone) B-cells were dramatically reduced in the mice bearing TA3-Ha cells but not in those bearing TA3-St cells, this being consistent with the finding that the thymus-independent response was reduced in these mice.
  • [MeSH-major] Adenocarcinoma / metabolism. B-Lymphocytes / immunology. Mucins / metabolism. Sialic Acid Binding Ig-like Lectin 2 / metabolism. Spleen / immunology

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  • (PMID = 18925876.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, T-Independent; 0 / Membrane Glycoproteins; 0 / Mucins; 0 / Receptors, Antigen, B-Cell; 0 / Sialic Acid Binding Ig-like Lectin 2; 0 / epiglycanin protein, mouse
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40. Dai ZK, Yu LM, Yang XS: [Anticancer effect of CL extract of Rosa roxburghii]. Zhongguo Zhong Yao Za Zhi; 2007 Jul;32(14):1453-7

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  • Cell toxicity of CL on human endometrial adenocarcinoma cell line JEC (JEC) cells was measured by MTT reduction test and growth curves drawing by trypan blue dye exclusion method.
  • RESULT: Comparing with the negative group, life span of EAC mice treated with CL was prolonged (P <0.05), and thymus index and spleen index of them were raised (P <0.05).
  • [MeSH-major] Adenocarcinoma / pathology. Antineoplastic Agents, Phytogenic / pharmacology. Drugs, Chinese Herbal / pharmacology. Endometrial Neoplasms / pathology. Rosa

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  • (PMID = 17966364.001).
  • [ISSN] 1001-5302
  • [Journal-full-title] Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  • [ISO-abbreviation] Zhongguo Zhong Yao Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Drugs, Chinese Herbal; EC 1.1.1.27 / L-Lactate Dehydrogenase
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41. Kaplan-Lefko PJ, Sutherland BW, Evangelou AI, Hadsell DL, Barrios RJ, Foster BA, Demayo F, Greenberg NM: Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis. Oncogene; 2008 May 1;27(20):2868-76
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  • Expression of IGF-1(des) was sufficient to cause hyperplastic lesions in all mice, however the well-differentiated lesions did not progress to adenocarcinoma within a year.
  • [MeSH-minor] Adenocarcinoma / secondary. Animals. Brain Neoplasms / secondary. Cell Differentiation / physiology. Epithelium / metabolism. Epithelium / pathology. Heart Neoplasms / secondary. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male. Mice. Mice, Transgenic. Splenic Neoplasms / secondary. Thymus Neoplasms / secondary. Urologic Neoplasms / secondary


42. Kanayama S, Matsuno A, Nagashima T, Ishida Y: Symptomatic pituitary metastasis of malignant thymoma. J Clin Neurosci; 2005 Nov;12(8):953-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Pituitary Neoplasms / secondary. Thymoma / secondary. Thymus Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Aged, 80 and over. Blepharoptosis / etiology. Humans. Magnetic Resonance Imaging. Male. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology. Vision Disorders / etiology

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  • (PMID = 16326276.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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43. Nakanishi T, Imaizumi K, Hasegawa Y, Kawabe T, Hashimoto N, Okamoto M, Shimokata K: Expression of macrophage-derived chemokine (MDC)/CCL22 in human lung cancer. Cancer Immunol Immunother; 2006 Nov;55(11):1320-9
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  • BACKGROUND: Ligands for CXCR3 chemokines [IFN-gamma-inducible protein of 10 kD (IP-10/CXCL10), monokine induced by IFN-gamma (Mig/CXCL9), IFN-inducible T cell alpha chemoattractant (I-TAC/CXCL11)] and those for CCR4 [macrophage-derived chemokine (MDC/CCL22), thymus- and activation-regulated chemokine (TARC/CCL17)] have been shown to play the central roles for T helper-cell recruitment into the tissues.
  • METHODS: Total RNA was prepared from lung cancer tissues of 40 patients (24 adenocarcinoma and 16 squamous cell carcinoma).
  • [MeSH-minor] Adenocarcinoma / metabolism. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. Chemokine CCL22. Disease-Free Survival. Female. Humans. Male. Middle Aged. Recurrence

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  • (PMID = 16453150.001).
  • [ISSN] 0340-7004
  • [Journal-full-title] Cancer immunology, immunotherapy : CII
  • [ISO-abbreviation] Cancer Immunol. Immunother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CCL22 protein, human; 0 / Chemokine CCL22; 0 / Chemokines, CC
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44. González-Alvarez M, Alzuet G, Borrás J, del Castillo-Agudo L, Montejo-Bernardo JM, Gutiérrez-Rodríguez A, García-Granda S: Evaluation of antiproliferative activities and apoptosis induction caused by copper(II)-benzothiazolesulfonamide complexes in Jurkat T lymphocytes and Caco-2 cells. J Biol Inorg Chem; 2008 Nov;13(8):1249-65
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  • The propensity for binding of 1 and 2 to calf thymus DNA was studied by thermal denaturation, viscosimetry, and cyclic voltammetry.
  • The biological studies carried out with human tumor cells, namely, colon adenocarcinoma Caco-2 cells (HTB-37) and leukemia Jurkat T lymphocytes (TIB-152), confirmed that both compounds inhibit the growth of these cell lines, although 2 is more effective.

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  • (PMID = 18651184.001).
  • [ISSN] 0949-8257
  • [Journal-full-title] Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
  • [ISO-abbreviation] J. Biol. Inorg. Chem.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzothiazoles; 0 / Cations, Divalent; 0 / Sulfonamides; 433-17-0 / 2-benzothiazolesulfonamide; 789U1901C5 / Copper; 9007-49-2 / DNA; 91080-16-9 / calf thymus DNA
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45. Sasmal PK, Saha S, Majumdar R, Dighe RR, Chakravarty AR: Photocytotoxic oxovanadium(IV) complexes showing light-induced DNA and protein cleavage activity. Inorg Chem; 2010 Feb 1;49(3):849-59
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  • The photocytotoxicity of complex 3 has been studied using adenocarcinoma A549 cells.
  • The complexes bind to calf thymus DNA giving binding constant values in the range of 6.6 x 10(4)-2.9 x 10(5) M(-1).
  • The dppz complex 3 also exhibits photocytotoxicity in non-small cell lung carcinoma/human lung adenocarcinoma A549 cells giving IC(50) value of 17 microM in visible light (IC(50) = 175 microM in dark).

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  • (PMID = 20039725.001).
  • [ISSN] 1520-510X
  • [Journal-full-title] Inorganic chemistry
  • [ISO-abbreviation] Inorg Chem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organometallic Compounds; 0 / Photosensitizing Agents; 0 / Serum Albumin, Bovine; 20644-97-7 / oxovanadium IV; 3WHH0066W5 / Vanadates; 9007-49-2 / DNA; 91080-16-9 / calf thymus DNA; EC 3.2.1.17 / Muramidase
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46. Sung YM, Lee KS, Kim BT, Choi JY, Shim YM, Yi CA: 18F-FDG PET/CT of thymic epithelial tumors: usefulness for distinguishing and staging tumor subgroups. J Nucl Med; 2006 Oct;47(10):1628-34
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  • [Title] 18F-FDG PET/CT of thymic epithelial tumors: usefulness for distinguishing and staging tumor subgroups.
  • The purpose of our study was to assess the usefulness of integrated PET/CT using 18F-FDG for distinguishing thymic epithelial tumors according to the World Health Organization (WHO) classification.
  • METHODS: Thirty-three patients (age range, 34-68 y; mean age, 54.6 y) with thymic epithelial tumors, who underwent both integrated PET/CT and enhanced CT, were included.
  • The clinicopathologic stages, maximum standardized uptake values (SUVs), and uptake patterns of tumors on integrated PET/CT images, and various enhanced CT findings, are described according to the simplified (low-risk [types A, AB, and B1] and high-risk [types B2 and B3] thymomas and thymic carcinomas) subgroups of the WHO classification.
  • RESULTS: Tumors included 8 low-risk thymomas, 9 high-risk thymomas, and 16 thymic carcinomas.
  • The maximum SUVs of high-risk thymomas (P < 0.001) and low-risk thymomas (P < 0.001) were found to be significantly lower than those of thymic carcinomas.
  • Homogeneous 18F-FDG uptake within tumors was more frequently seen in thymic carcinomas than in high-risk thymomas (P = 0.027) or low-risk thymomas (P = 0.001).
  • CONCLUSION: Integrated PET/CT was found to be useful for differentiating subgroups of thymic epithelial tumors and for staging the extent of the disease.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Fluorodeoxyglucose F18. Radiopharmaceuticals. Thymoma / diagnosis. Thymus Neoplasms / diagnosis

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  • (PMID = 17015898.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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47. Pantidou A, Kiziridou A, Antoniadis T, Tsilikas C, Destouni C: Mediastinum thymoma diagnosed by FNA and ThinPrep technique: a case report. Diagn Cytopathol; 2006 Jan;34(1):37-40

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  • Thymoma is a primary tumor of the thymus epithelial cells.
  • This is an interesting case of thymoma diagnosed by fine-needle aspiration biopsy (FNA) and ThinPrep technique, in a 54-year-old female patient with a history of gastric adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / pathology. Female. Histocytological Preparation Techniques. Humans. Middle Aged. Neoplasms, Second Primary / diagnosis. Stomach Neoplasms / pathology

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  • (PMID = 16355373.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Muro M, Yoshioka T, Idani H, Sasaki H, Asami S, Nakano K, Nojima H, Kubo S, Kurose Y, Kumano K, Kin H, Takakura N: [Simultaneously treated thymoma and lung cancer; report of a case]. Kyobu Geka; 2010 Nov;63(12):1087-9
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  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / complications. Lung Neoplasms / complications. Neoplasms, Multiple Primary. Thymoma / complications. Thymus Neoplasms / complications

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  • (PMID = 21066854.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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49. Harrington CF, Le Pla RC, Jones GD, Thomas AL, Farmer PB: Determination of cisplatin 1,2-intrastrand guanine-guanine DNA adducts in human leukocytes by high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry. Chem Res Toxicol; 2010 Aug 16;23(8):1313-21
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  • The method was developed and validated using calf thymus DNA and two different adenocarcinoma cell lines.

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  • (PMID = 20666396.001).
  • [ISSN] 1520-5010
  • [Journal-full-title] Chemical research in toxicology
  • [ISO-abbreviation] Chem. Res. Toxicol.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/D524416/1; United Kingdom / Medical Research Council / / G0100873
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / DNA Adducts; 0 / DNA, Neoplasm; 5Z93L87A1R / Guanine; 9007-49-2 / DNA; 91080-16-9 / calf thymus DNA; Q20Q21Q62J / Cisplatin
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50. Check JH, Dix E, Cohen R, Check D, Wilson C: Efficacy of the progesterone receptor antagonist mifepristone for palliative therapy of patients with a variety of advanced cancer types. Anticancer Res; 2010 Feb;30(2):623-8
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  • RESULTS: Improvement in pain and energy and/or length of life was found in thymic epithelial cell carcinoma, transitional cell carcinoma of the renal pelvis, leiomyosarcoma, pancreatic carcinoma, malignant fibrous histiocytoma and another case of adenocarcinoma of the colon.
  • [MeSH-minor] Adult. Aged. Carcinoma, Transitional Cell / drug therapy. Carcinoma, Transitional Cell / secondary. Colonic Neoplasms / drug therapy. Colonic Neoplasms / pathology. Female. Histiocytoma, Malignant Fibrous / drug therapy. Histiocytoma, Malignant Fibrous / pathology. Humans. Kidney Neoplasms / drug therapy. Kidney Neoplasms / pathology. Leiomyosarcoma / drug therapy. Leiomyosarcoma / secondary. Male. Middle Aged. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / pathology. Survival Rate. Thymus Neoplasms / drug therapy. Thymus Neoplasms / pathology. Treatment Outcome. Young Adult

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  • (PMID = 20332480.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Hormone Antagonists; 0 / Receptors, Progesterone; 320T6RNW1F / Mifepristone
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51. Pettinari A, Amici M, Cuccioloni M, Angeletti M, Fioretti E, Eleuteri AM: Effect of polyphenolic compounds on the proteolytic activities of constitutive and immuno-proteasomes. Antioxid Redox Signal; 2006 Jan-Feb;8(1-2):121-9
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  • [MeSH-minor] Adenocarcinoma. Animals. Brain / enzymology. Catechin / analogs & derivatives. Catechin / pharmacology. Cattle. Cell Line, Tumor. Colonic Neoplasms. Gallic Acid / pharmacology. Humans. Oxidation-Reduction. Polyphenols. Thymus Gland / enzymology. Urokinase-Type Plasminogen Activator / antagonists & inhibitors

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  • (PMID = 16487045.001).
  • [ISSN] 1523-0864
  • [Journal-full-title] Antioxidants & redox signaling
  • [ISO-abbreviation] Antioxid. Redox Signal.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Flavonoids; 0 / Phenols; 0 / Polyphenols; 632XD903SP / Gallic Acid; 8R1V1STN48 / Catechin; BQM438CTEL / epigallocatechin gallate; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator; EC 3.4.25.1 / Proteasome Endopeptidase Complex
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52. Sun XY, Zheng YP, Lin DH, Zhang H, Zhao F, Yuan CS: Potential anti-cancer activities of Furanodiene, a Sesquiterpene from Curcuma wenyujin. Am J Chin Med; 2009;37(3):589-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma. Animals. Breast Neoplasms. Carcinoma, Hepatocellular. Cell Division / drug effects. Female. Fibrosarcoma / drug therapy. Fibrosarcoma / pathology. HL-60 Cells. HeLa Cells. Humans. K562 Cells. Leukemia. Liver Neoplasms. Lung Neoplasms. Mice. Mice, Inbred Strains. Organ Size. Spleen / pathology. Thymus Gland / pathology. Xenograft Model Antitumor Assays

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  • (PMID = 19606517.001).
  • [ISSN] 0192-415X
  • [Journal-full-title] The American journal of Chinese medicine
  • [ISO-abbreviation] Am. J. Chin. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Furans; 0 / Heterocyclic Compounds, 2-Ring; 0 / Sesquiterpenes; 19912-61-9 / furanodiene
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53. Herth FJ, Morgan RK, Eberhardt R, Ernst A: Endobronchial ultrasound-guided miniforceps biopsy in the biopsy of subcarinal masses in patients with low likelihood of non-small cell lung cancer. Ann Thorac Surg; 2008 Jun;85(6):1874-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / ultrasonography. Adult. Aged. Diagnosis, Differential. Equipment Design. Female. Hodgkin Disease / pathology. Hodgkin Disease / ultrasonography. Humans. Lung / pathology. Lymph Nodes / pathology. Lymph Nodes / ultrasonography. Male. Middle Aged. Needles. Prospective Studies. Sarcoidosis, Pulmonary / pathology. Sarcoidosis, Pulmonary / ultrasonography. Thymoma / pathology. Thymoma / ultrasonography. Thymus Neoplasms / pathology. Thymus Neoplasms / ultrasonography. Thyroid Neoplasms / pathology. Thyroid Neoplasms / ultrasonography

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  • [CommentIn] Ann Thorac Surg. 2008 Jun;85(6):1879 [18498787.001]
  • (PMID = 18498786.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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54. Papi G, Corrado S, LiVolsi VA: Primary spindle cell lesions of the thyroid gland; an overview. Am J Clin Pathol; 2006 Jun;125 Suppl:S95-123
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  • Primary T-SCL can be derivedfromfollicular, C-cell (parafollicular), or mesenchymal components and may be the result of reactive or neoplastic processes, including post-fine-needle aspiration spindle cell nodules, Riedel thyroiditis, solitary fibrous tumor, leiomyoma, peripheral nerve sheath tumor, hyalinizing trabecular tumor, spindle epithelial tumor with thymus-like differentiation, follicular dendritic cell tumor, medullary carcinoma, papillary carcinoma, anaplastic carcinoma, sarcoma, squamous cell carcinoma, and carcinoma showing thymus-like differentiation.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Neoplasms, Fibrous Tissue / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 16830961.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 354
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55. Talmon GA, Lewis JE: Lymphocyte-depleted thymic remnants: a potential diagnostic pitfall in the evaluation of central neck dissections. Am J Clin Pathol; 2009 Nov;132(5):707-12
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  • [Title] Lymphocyte-depleted thymic remnants: a potential diagnostic pitfall in the evaluation of central neck dissections.
  • Several lesions are thymic in origin.
  • We report 3 cases of lymphocyte-poor thymic remnants identified in central cervical (level VI) lymph node dissections for unrelated benign and malignant pathology.
  • These cells were immunophenotypically similar to thymic epithelial cells, although they differed in the paucity of associated thymic lymphocytes and lack of Hassall corpuscles.
  • Lymphocyte-depleted thymic remnants in the central cervical compartment are not well described in the literature.
  • [MeSH-major] Incidental Findings. Neck Dissection. Thymus Gland / pathology
  • [MeSH-minor] Adenocarcinoma, Papillary / surgery. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Head and Neck Neoplasms / pathology. Humans. Hyperparathyroidism / surgery. Immunohistochemistry. Lymphocytes / pathology. Male. Parathyroidectomy. Thyroid Neoplasms / surgery

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  • (PMID = 19846811.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Scolaro C, Bergamo A, Brescacin L, Delfino R, Cocchietto M, Laurenczy G, Geldbach TJ, Sava G, Dyson PJ: In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes. J Med Chem; 2005 Jun 16;48(12):4161-71
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  • In vitro biological experiments demonstrate that these compounds are active toward the TS/A mouse adenocarcinoma cancer cell line whereas cytotoxicity on the HBL-100 human mammary (nontumor) cell line was not observed at concentrations up to 0.3 mM, which indicates selectivity of these ruthenium(II)-arene complexes to cancer cells.

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  • (PMID = 15943488.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 1,3,5-triaza-7-phosphaadamantane; 0 / Antineoplastic Agents; 0 / Benzene Derivatives; 0 / Buffers; 0 / Organometallic Compounds; 0 / Organophosphorus Compounds; 0 / Solutions; 451W47IQ8X / Sodium Chloride; 7UI0TKC3U5 / Ruthenium; 9007-49-2 / DNA; 91080-16-9 / calf thymus DNA; PJY633525U / Adamantane
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57. Gallego J, Cruz J, Mendes S, Caldeira J, Nobre A, Cravino J: [Surgery of mediastinal tumors: 11-years experience]. Rev Port Cir Cardiotorac Vasc; 2005 Apr-Jun;12(2):73-8

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  • In 70 patients treated, 63 p (90%) had the tumor located in the anterior mediastinum, 21 p with thymoma, 6 p with lymphoma, 4 p with carcinoid tumors, 1 p with sarcoma and 1 p with adenocarcinoma.
  • [MeSH-minor] Carcinoid Tumor / surgery. Female. Humans. Lymphoma / surgery. Male. Retrospective Studies. Thymoma / pathology. Thymoma / surgery. Thymus Neoplasms / pathology. Thymus Neoplasms / surgery

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  • (PMID = 16077878.001).
  • [ISSN] 0873-7215
  • [Journal-full-title] Revista portuguesa de cirurgia cardio-torácica e vascular : órgão oficial da Sociedade Portuguesa de Cirurgia Cardio-Torácica e Vascular
  • [ISO-abbreviation] Rev Port Cir Cardiotorac Vasc
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Portugal
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58. Tokairin Y, Kakinuma S, Arai M, Nishimura M, Okamoto M, Ito E, Akashi M, Miki Y, Kawano T, Iwai T, Shimada Y: Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCC. Int J Exp Pathol; 2006 Apr;87(2):89-99
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  • Mlh1-/- mice spontaneously developed GIT and thymic lymphomas by 48 weeks.
  • Mlh1+/- and Mlh1+/+ mice were not susceptible to spontaneous or radiation-induced thymic lymphomas and GIT until 72 weeks after birth.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenocarcinoma / etiology. Animals. Base Pair Mismatch / genetics. Carrier Proteins / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / pathology. Colorectal Neoplasms, Hereditary Nonpolyposis / radiotherapy. Disease Models, Animal. Disease Progression. Genes, Neoplasm / genetics. Immunohistochemistry / methods. Lymphoma / etiology. Mice. Mice, Knockout. Mutation / genetics. Neoplasm Proteins / analysis. Nuclear Proteins / deficiency. Nuclear Proteins / genetics. Radiotherapy / adverse effects. Receptors, Transforming Growth Factor beta / genetics. Thymus Neoplasms / etiology. Transforming Growth Factor beta / analysis. Transforming Growth Factor beta2. Tumor Suppressor Protein p53 / analysis. beta Catenin / analysis

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  • (PMID = 16623753.001).
  • [ISSN] 0959-9673
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / Mlh1 protein, mouse; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Receptors, Transforming Growth Factor beta; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta2; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
  • [Other-IDs] NLM/ PMC2517356
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59. Zhou P, Fang X, McNally BA, Yu P, Zhu M, Fu YX, Wang L, Liu Y, Zheng P: Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition. Proc Natl Acad Sci U S A; 2009 Oct 6;106(40):17134-9
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

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  • To address this issue, we explored a non-antigen-based cancer immune prevention strategy using the transgenic adenocarcinoma of mouse prostate model that spontaneously develops prostate cancer with 100% penetrance.

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  • (PMID = 19805094.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA112001; United States / NCI NIH HHS / CA / R01 CA112001-04; United States / NCI NIH HHS / CA / R01 CA112001-03; United States / NCI NIH HHS / CA / CA112001-04; United States / NCI NIH HHS / CA / CA112001-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin Fc Fragments; 0 / Lymphotoxin beta Receptor; 0 / Lymphotoxin-alpha; 0 / Receptors, Tumor Necrosis Factor, Member 25; 0 / Recombinant Fusion Proteins; 0 / Tnfrsf25 protein, mouse
  • [Other-IDs] NLM/ PMC2761305
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60. Ruan Q, Kim HY, Jiang H, Penning TM, Harvey RG, Blair IA: Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom; 2006;20(8):1369-80
Hazardous Substances Data Bank. Adenosine .

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  • The LC-MRM/MS assay was rigorously validated and used to show that (+)-anti-trans-B[a]PDE-dGuo was the major adduct formed when naked DNA and human bronchoalveolar adenocarcinoma H358 cells were treated with (+/-)-anti-B[a]PDE.
  • [MeSH-minor] Adenosine / chemistry. Animals. Bronchoalveolar Lavage Fluid / cytology. Calibration. Cattle. Cell Line, Tumor. Chromatography, High Pressure Liquid. Circular Dichroism. Guanosine / chemistry. Humans. Hydrolysis. Molecular Conformation. Quality Control. Reproducibility of Results. Tandem Mass Spectrometry. Thymus Gland / chemistry

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  • [Copyright] Copyright 2006 John Wiley & Sons, Ltd.
  • (PMID = 16557497.001).
  • [ISSN] 0951-4198
  • [Journal-full-title] Rapid communications in mass spectrometry : RCM
  • [ISO-abbreviation] Rapid Commun. Mass Spectrom.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01 CA 92537
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzopyrenes; 0 / DNA Adducts; 12133JR80S / Guanosine; 60268-85-1 / benzo(a)pyrene diolepoxide I; K72T3FS567 / Adenosine
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61. Pastorino U, Yang XN, Francese M, Durkovic S, Biglioli P: Long-term survival after salvage surgery for invasive thymoma with intracardiac extension. Tumori; 2008 Sep-Oct;94(5):772-6
Hazardous Substances Data Bank. TEFLON .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Heart Neoplasms / secondary. Heart Neoplasms / surgery. Salvage Therapy / methods. Thymectomy. Thymoma / secondary. Thymoma / surgery. Thymus Neoplasms / pathology. Thymus Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Blood Vessel Prosthesis. Cardiac Surgical Procedures. Cardiopulmonary Bypass. Female. Heart Atria / pathology. Heart Atria / surgery. Humans. Lung Neoplasms / surgery. Middle Aged. Neoplasm Invasiveness. Neoplasms, Second Primary / surgery. Polytetrafluoroethylene. Tomography, X-Ray Computed. Treatment Outcome. Vascular Surgical Procedures / methods. Vena Cava, Superior / pathology. Vena Cava, Superior / surgery

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  • (PMID = 19112960.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 9002-84-0 / Polytetrafluoroethylene
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62. Zhang L, Huang H, Wu K, Wang M, Wu B: Impact of BTG2 expression on proliferation and invasion of gastric cancer cells in vitro. Mol Biol Rep; 2010 Jul;37(6):2579-86
MedlinePlus Health Information. consumer health - Stomach Cancer.

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  • BTG2 (B cell translocation gene 2) is downregulated in several human tumors and has been known as a tumor suppressor in carcinogenesis of thymus, prostate, kidney, and liver.
  • However, little is known about the role BTG2 plays in gastric adenocarcinoma.

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  • [ISO-abbreviation] Mol. Biol. Rep.
  • [Language] eng
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63. Sitić S, Mirt-Dabić M, Brcić L, Juros Z, Hutinec Z, Kruslin B: DNA ploidy in thymoma and associated multiple primary malignancies in the same patient. Acta Clin Croat; 2008 Sep;47(3):155-9
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Thymoma is an uncommon neoplasm derived from thymic epithelium.
  • Thymoma may be associated with different types of additional primary malignancies; however, colorectal adenocarcinoma and thyroid cancer appear to be most common.
  • [MeSH-major] DNA, Neoplasm / genetics. Neoplasms, Multiple Primary / genetics. Ploidies. Thymoma / genetics. Thymus Neoplasms / genetics

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  • (PMID = 19175064.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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64. Hansson M, Hermansson M, Svensson H, Elfvin A, Hansson LE, Johnsson E, Sjöling A, Quiding-Järbrink M: CCL28 is increased in human Helicobacter pylori-induced gastritis and mediates recruitment of gastric immunoglobulin A-secreting cells. Infect Immun; 2008 Jul;76(7):3304-11
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

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  • Human Helicobacter pylori infection gives rise to an active chronic gastritis and is a major risk factor for the development of duodenal ulcer disease and gastric adenocarcinoma.
  • To identify the signals for recruitment of gastric IgA-secreting cells, we investigated the gastric production of CCL28 (mucosa-associated epithelial chemokine) and CCL25 (thymus-expressed chemokine) in H. pylori-infected and uninfected individuals and the potential of gastric B-cell populations to migrate toward these chemokines.

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  • (PMID = 18426876.001).
  • [ISSN] 1098-5522
  • [Journal-full-title] Infection and immunity
  • [ISO-abbreviation] Infect. Immun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCL25 protein, human; 0 / CCL28 protein, human; 0 / Chemokines, CC; 0 / Immunoglobulin A, Secretory
  • [Other-IDs] NLM/ PMC2446710
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65. Zhou P, Zheng X, Zhang H, Liu Y, Zheng P: B7 blockade alters the balance between regulatory T cells and tumor-reactive T cells for immunotherapy of cancer. Clin Cancer Res; 2009 Feb 1;15(3):960-70
COS Scholar Universe. author profiles.

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  • The treatment was also tested in treating transplanted MC38 colon adenocarcinoma in mice.
  • Correspondingly, this treatment results in a transient reduction of Treg in both thymus and the periphery.

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  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AI064350-03; United States / NCI NIH HHS / CA / R01 CA112001; United States / NIAID NIH HHS / AI / R01 AI064350; United States / NCI NIH HHS / CA / CA12001; United States / NCI NIH HHS / CA / R01 CA112001-04; United States / NIAID NIH HHS / AI / AI064350; United States / NCI NIH HHS / CA / CA112001-04; United States / NIAID NIH HHS / AI / R01 AI064350-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 107-1A4 monoclonal antibody; 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Antigens, CD80; 0 / Antigens, CD86; 0 / Interleukin-2 Receptor alpha Subunit
  • [Other-IDs] NLM/ NIHMS96787; NLM/ PMC2693886
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66. O'Gorman CS, Hamilton J, Rachmiel M, Gupta A, Ngan BY, Daneman D: Thyroid cancer in childhood: a retrospective review of childhood course. Thyroid; 2010 Apr;20(4):375-80
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  • Twenty-seven patients had metastases at presentation (19 lymph nodes only, 2 lung only, and 6 lymph node and distant) and 6 developed distant metastases during follow-up (3 lung, 2 thymus, and 1 paraspinal).
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / surgery. Adolescent. Canada / epidemiology. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Child. Female. Humans. Iodine Radioisotopes / therapeutic use. Lymphatic Metastasis. Male. Retrospective Studies. Thyroidectomy

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  • (PMID = 20373982.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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67. Lamani DS, Reddy KR, Naik HS, Pai KS, Kumar R, Naik HR, Naik LR: Synthesis, antitumor, and DNA binding behavior of novel 4-(2-hydroxyquinolin-3-yl)-6-phenyl-5, 6 dihydropyrimidin derivatives in aqueous medium. Nucleosides Nucleotides Nucleic Acids; 2010 Aug;29(8):591-605
Hazardous Substances Data Bank. Water .

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  • The compounds (2a and 2b) were evaluated for in vitro cyctotoxicity against human breast adenocarcinoma cell (MCF-7).
  • The binding interaction behavior of the compound (2a) and (2d) with calf thymus-DNA (CT-DNA) was studied by electronic spectra, viscosity measurements, and thermal denaturation studies.

  • Hazardous Substances Data Bank. METHYLTHIAZOLETETRAZOLIUM .
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  • (PMID = 20661813.001).
  • [ISSN] 1532-2335
  • [Journal-full-title] Nucleosides, nucleotides & nucleic acids
  • [ISO-abbreviation] Nucleosides Nucleotides Nucleic Acids
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Antineoplastic Agents; 0 / Chalcones; 0 / Hydroxyquinolines; 0 / Ketones; 0 / Pyrimidines; 0 / Tetrazolium Salts; 0 / Thiazoles; 059QF0KO0R / Water; 298-93-1 / thiazolyl blue; 9007-49-2 / DNA
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68. Ten Dam GB, Yamada S, Kobayashi F, Purushothaman A, van de Westerlo EM, Bulten J, Malmström A, Sugahara K, Massuger LF, van Kuppevelt TH: Dermatan sulfate domains defined by the novel antibody GD3A12, in normal tissues and ovarian adenocarcinomas. Histochem Cell Biol; 2009 Jul;132(1):117-27
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  • Differential expression of the DS epitopes recognized by antibodies GD3A12 and LKN1 (4/2,4 di-O-sulfated DS) was best seen in thymus and spleen, indicating differential expression of various DS domains in these organs.
  • [MeSH-major] Adenocarcinoma / metabolism. Antibodies / immunology. Dermatan Sulfate / metabolism. Ovarian Neoplasms / metabolism. Ovary / metabolism

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  • (PMID = 19360434.001).
  • [ISSN] 1432-119X
  • [Journal-full-title] Histochemistry and cell biology
  • [ISO-abbreviation] Histochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies; 0 / Epitopes; 24967-94-0 / Dermatan Sulfate
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69. Liu Y, Chen T, Wong YS, Mei WJ, Huang XM, Yang F, Liu J, Zheng WJ: DNA binding and photocleavage properties and apoptosis-inducing activities of a ruthenium porphyrin complex [(Py-3')TPP-Ru(phen)2Cl]Cl and its heterometallic derivatives. Chem Biol Interact; 2010 Feb 12;183(3):349-56
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  • The interactions of a ruthenium porphyrin complex [(Py-3')TPP-Ru(phen)(2)Cl]Cl (phen=1,10-phenanthroline, (Py-3')TPP=5-(3'-pyridyl-10,15,20-triphenylporphyrin) (1) and its heterometallic derivatives, [Ni(Py-3')TPP-Ru(phen)(2)Cl][PF(6)] (2) and [Cu(Py-3')TPP-Ru(phen)(2)Cl][PF(6)] (3), with calf thymus DNA have been investigated by spectroscopic and viscosity measurements in this study.
  • As determined by MTT assay, the complexes were also identified as potent antiproliferative agents against A375 human melanoma cells, MCF-7 human breast adrenocarcinoma cells, Colo201 human colon adenocarcinoma cells and HepG2 human liver cancer cells.

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19958751.001).
  • [ISSN] 1872-7786
  • [Journal-full-title] Chemico-biological interactions
  • [ISO-abbreviation] Chem. Biol. Interact.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / ((Py-3')TPP-Ru(phen)2Cl)Cl; 0 / (Cu(Py-3')TPP-Ru(phen)2Cl)(PF6); 0 / (Ni(Py-3')TPP-Ru(phen)2Cl)(PF6); 0 / Metalloporphyrins; 0 / Proto-Oncogene Proteins c-bcl-2; 9007-49-2 / DNA
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70. Hosaka Y, Tsuchida M, Toyabe S, Umezu H, Eimoto T, Hayashi J: Masaoka stage and histologic grade predict prognosis in patients with thymic carcinoma. Ann Thorac Surg; 2010 Mar;89(3):912-7
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  • [Title] Masaoka stage and histologic grade predict prognosis in patients with thymic carcinoma.
  • BACKGROUND: Thymic carcinoma is a rare tumor.
  • Limited data are available regarding the effectiveness of treatment and the prognosis of thymic carcinoma.
  • METHODS: The study retrospectively reviewed 21 patients (15 men, 6 women) with thymic carcinoma who had undergone resection at Niigata University Hospital.
  • Histologic subtypes were squamous cell carcinoma in 14 patients, adenocarcinoma in 2, atypical carcinoid in 3, and undifferentiated carcinoma in 2.
  • CONCLUSIONS: The surgical outcome of patients with thymic carcinoma depends on the Masaoka stage and histologic grade.
  • [MeSH-major] Thymoma / pathology. Thymus Neoplasms / pathology

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20172153.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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71. Hille A, Ott I, Kitanovic A, Kitanovic I, Alborzinia H, Lederer E, Wölfl S, Metzler-Nolte N, Schäfer S, Sheldrick WS, Bischof C, Schatzschneider U, Gust R: [N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties. J Biol Inorg Chem; 2009 Jun;14(5):711-25
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Animals. Breast Neoplasms / drug therapy. Carcinoma / drug therapy. Cattle. Cell Line, Tumor. Circular Dichroism. Colonic Neoplasms / drug therapy. DNA / metabolism. Electric Impedance. Female. Humans. Oxidation-Reduction. Oxygen Consumption / drug effects. Reactive Oxygen Species / metabolism. Thymus Gland / metabolism

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  • (PMID = 19259708.001).
  • [ISSN] 1432-1327
  • [Journal-full-title] Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
  • [ISO-abbreviation] J. Biol. Inorg. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chelating Agents; 0 / Metals; 0 / Reactive Oxygen Species; 0 / Salicylates; 118-57-0 / salophen; 9007-49-2 / DNA
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72. Johnson EL, Singh R, Singh S, Johnson-Holiday CM, Grizzle WE, Partridge EE, Lillard JW Jr: CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion. World J Surg Oncol; 2010 Jul 22;8:62
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chemokine receptor CCR9 is primarily expressed by a small subset of immune cells and its only natural ligand, CCL25, is largely expressed in the thymus, which involutes with age.
  • Other than the thymus, CCL25 is expressed by the small bowel.
  • RESULTS: Our results show significantly (p<0.001) higher expression of CCR9 by mucinous adenocarcinoma, papillary serous carcinoma, and endometriod ovarian carcinoma cases, than compared to non-neoplastic ovarian tissue.

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  • (PMID = 20649989.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] ENG
  • [Grant] United States / NIMHD NIH HHS / MD / MD00525; United States / NCRR NIH HHS / RR / RR03034; United States / NIDDK NIH HHS / DK / DK58967; United States / NIGMS NIH HHS / GM / GM08248; United States / NCI NIH HHS / CA / CA086359; United States / NCI NIH HHS / CA / CA092078
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CC chemokine receptor 9; 0 / CCL25 protein, human; 0 / Chemokines, CC; 0 / RNA, Messenger; 0 / Receptors, CCR; EC 3.4.- / Metalloproteases
  • [Other-IDs] NLM/ PMC2927595
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73. NTP technical report on the toxicology and carcinogenesis studies of 1,2-dibromo-2,4-dicyanobutane (CAS No. 35691-65-7) in F344/N rats and B6C3F1 mice (dermal studies). Natl Toxicol Program Tech Rep Ser; 2010 Jun;(555):1-171
Hazardous Substances Data Bank. 1,2-DIBROMO-2,4-DICYANOBUTANE .

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  • The thymus weights of males administered 300 mg/kg or greater and those of all dosed groups of females were significantly decreased.
  • The combined incidence of mammary gland fibroadenoma, adenoma, or adenocarcinoma occurred with a negative trend, and the incidence was significantly decreased in 6 mg/kg female rats.

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  • (PMID = 20725155.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nitriles; YX089CPS05 / 1,2-dibromo-2,4-dicyanobutane
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74. Hansen EK, Krieg RM, Azar RJ, Jablons DM, Jahan TM, Zaloudek CJ: Unusual thoracic problems in patients with malignancies: case 3. Carcinoid tumor of the thymus. J Clin Oncol; 2005 Apr 20;23(12):2859-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual thoracic problems in patients with malignancies: case 3. Carcinoid tumor of the thymus.

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  • (PMID = 15838001.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA093708-01A3; United States / NCI NIH HHS / CA / R01 CA093708; United States / NCI NIH HHS / CA / R01 CA093708-01A3
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Starobin D, Katz M, Huszar M, Shtoeger Z: Coincidental lung presentation of two synchronous non-pulmonary tumors. Isr Med Assoc J; 2008 Aug-Sep;10(8-9):595-6
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / diagnosis. Choristoma / diagnosis. Lung Diseases / diagnosis. Neoplasms, Multiple Primary / diagnosis. Thymoma / diagnosis. Thymus Neoplasms / diagnosis. Thyroid Neoplasms / diagnosis

  • MedlinePlus Health Information. consumer health - Lung Diseases.
  • MedlinePlus Health Information. consumer health - Thymus Cancer.
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  • (PMID = 18847159.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Israel
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