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1. Milathianakis CN, Karamanolakis DK, Massoud WA, Roumier X, Bogdanos IM, Perrin P: [Vaginal metastases from renal cell carcinoma]. Prog Urol; 2005 Apr;15(2):319-21
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  • [Title] [Vaginal metastases from renal cell carcinoma].
  • Renal cell carcinoma rarely metastasizes to the vagina, as only 80 cases have been reported in the literature.
  • Due to the anatomical features of the venous drainage of the left kidney, most vaginal metastases are derived from left renal tumours.
  • Renal imaging looking for a renal tumour must be performed in the presence of a vaginal adenocarcinoma or undifferentiated carcinoma.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Vaginal Neoplasms / secondary

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  • (PMID = 15999617.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 6
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2. Salihoğlu Y, Keskin N, Topuz S, Küçücük S, Iyibozkurt C: Analysis of vaginal recurrences in stage I endometrial adenocarcinoma. Eur J Gynaecol Oncol; 2007;28(4):313-5
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  • [Title] Analysis of vaginal recurrences in stage I endometrial adenocarcinoma.
  • OBJECTIVE: To determine the risk of vaginal recurrence in Stage 1 endometrial cancer and treatment morbidity associated with different therapeutic approaches MATERIAL AND METHODS: Between 1995 and 2005, 341 patients with clinical Stage I endometrial cancer were treated at Istanbul Medical Faculty.
  • When there was superficial myometrial invasion postoperative vaginal vault radiation was used, and if deep myometrial invasion was present, external pelvic radiation was given.
  • Nine patients (6.25%) developed recurrent disease, three of whom had vaginal recurrences.
  • All three vaginal recurrences were small and diagnosed at routine follow-up exam within 51 months of primary therapy.
  • CONCLUSION: This selective treatment protocol for patients with Stage I endometrial cancer avoided radiation entirely in 38% of the patients while achieving a very low rate of vaginal recurrence and good overall survival.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Squamous Cell / pathology. Endometrial Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Vagina / pathology

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  • (PMID = 17713101.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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3. Uehara T, Onda T, Sasajima Y, Sawada M, Kasamatsu T: A case of vaginal clear cell adenocarcinoma complicated with congenital anomalies of the genitourinary tract and metanephric remnant without prenatal diethylstilbestrol exposure. J Obstet Gynaecol Res; 2010 Jun;36(3):681-5
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  • [Title] A case of vaginal clear cell adenocarcinoma complicated with congenital anomalies of the genitourinary tract and metanephric remnant without prenatal diethylstilbestrol exposure.
  • Vaginal clear cell adenocarcinoma (CCA) is well known to be associated with prenatal diethylstilbestrol exposure.
  • We present a vaginal CCA with congenital anomalies of the genitourinary tract without prenatal diethylstilbestrol exposure.
  • The examination revealed CCA at the anterior vagina and congenital anomalies.
  • Macroscopically, bicornuate uterus, vaginal septum and left ureteral agenesis were found.
  • Microscopically, vaginal CCA coexisted with adenosis and both metanephric and mesonephric remnants.
  • The vaginal CCA was supposed to derive from coexisting adenosis.
  • Relations between congenital anomalies of the genitourinary tract and vaginal adenocarcinoma were suspected, resultantly.
  • [MeSH-major] Adenocarcinoma, Clear Cell / complications. Adenocarcinoma, Clear Cell / pathology. Urogenital Abnormalities / complications. Vaginal Neoplasms / complications. Vaginal Neoplasms / pathology

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  • (PMID = 20598057.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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4. Laurent S, Barbeaux A, Detroz B, Detry O, Louis E, Belaiche J, Meurisse M: Development of adenocarcinoma in chronic fistula in Crohn's disease. Acta Gastroenterol Belg; 2005 Jan-Mar;68(1):98-100
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  • [Title] Development of adenocarcinoma in chronic fistula in Crohn's disease.
  • Long-standing anorectal fistulas and stricture led to adenocarcinoma and finally fistulisation in the vagina.
  • Diagnosis was made by perineal examination with biopsies under general anaesthesia.
  • Treatment was first posterior pelvectomy with resection of the anterior wall of vagina.
  • [MeSH-major] Adenocarcinoma / pathology. Crohn Disease / pathology. Precancerous Conditions / pathology. Rectal Neoplasms / pathology. Rectovaginal Fistula / pathology

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  • (PMID = 15832595.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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5. Coughlan C, McAuliffe F, Bermingham N, Gleeson N: Vaginal cytology following primary hysterectomy for cervical cancer: is it useful? Ir J Med Sci; 2006 Jan-Mar;175(1):45-9
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  • [Title] Vaginal cytology following primary hysterectomy for cervical cancer: is it useful?
  • BACKGROUND: Vaginal intraepithelial neoplasia (VAIN) is usually detected in patients with synchronous or antecedent cervical or vulval intraepithelial or invasive cancer.
  • AIMS: To determine the incidence and severity and analyse the management of vaginal dysplasia in patients undergoing primary hysterectomy for cervical cancer.
  • RESULTS: In follow-up six patients were found to have dyskaryosis in a second vaginal smear.
  • One patient with recurrent squamous cancer received salvage radiotherapy and one with recurrent adenocarcinoma received high dose progestogens and topical 5-fluorouracil.
  • [MeSH-major] Hysterectomy. Uterine Cervical Neoplasms / diagnosis. Vagina / cytology. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Middle Aged. Retrospective Studies. Vaginal Smears / utilization


6. Kasamatsu T, Onda T, Sawada M, Kato T, Ikeda S, Sasajima Y, Tsuda H: Radical hysterectomy for FIGO stage I-IIB adenocarcinoma of the uterine cervix. Br J Cancer; 2009 May 5;100(9):1400-5
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  • [Title] Radical hysterectomy for FIGO stage I-IIB adenocarcinoma of the uterine cervix.
  • A retrospective analysis was carried out to identify risk factors for survival and relapse in patients with FIGO stage I-IIB cervical adenocarcinoma (AC), who underwent radical hysterectomy, and to compare outcome and spread pattern with those of squamous cell carcinoma (SCC).
  • Among the patients with AC, Cox model identified tumour size (95% CI: 1.35-30.71) and node metastasis (95% CI: 5.09-53.44) as independent prognostic factors for survival, and infiltration to vagina (95% CI: 1.15-5.76) and node metastasis (95% CI: 6.39-58.87) as independent prognostic factors for relapse.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Hysterectomy. Uterine Cervical Neoplasms / pathology. Uterine Cervical Neoplasms / surgery
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Lymphatic Metastasis / pathology. Neoplasm Staging. Prognosis. Recurrence. Retrospective Studies. Survivors. Time Factors. Vaginal Neoplasms / pathology


7. Sameshima H, Nagai K, Ikenoue T: Single vaginal ectopic ureter of fetal metanephric duct origin, ipsilateral kidney agenesis, and ipsilateral rudimentary uterine horn of the bicornuate uterus. Gynecol Oncol; 2005 Apr;97(1):276-8
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  • [Title] Single vaginal ectopic ureter of fetal metanephric duct origin, ipsilateral kidney agenesis, and ipsilateral rudimentary uterine horn of the bicornuate uterus.
  • CASE: Two Japanese women had a single ectopic ureter opening in the central wall of the vagina, ipsilateral kidney agenesis, and ipsilateral rudimentary uterine horn of the bicornuate uterus.
  • One had squamous cell carcinoma of the uterine cervix, and the other had adenocarcinoma of the vagina arising from the ectopic ureter meatus, which was histologically confirmed as fetal metanephric duct remnant.
  • One had vesico-vaginal fistula postoperatively, resulting from separating the ureter-like duct from the bladder.
  • Clinically, the ectopic vaginal ureter is important as a possible background of vaginal adenocarcinoma, and information on the ureter-like duct course is required during surgery.
  • [MeSH-major] Adenocarcinoma / etiology. Carcinoma, Squamous Cell / etiology. Kidney / abnormalities. Ureter / abnormalities. Uterine Cervical Neoplasms / etiology. Uterus / abnormalities. Vaginal Neoplasms / etiology


8. Kasamatsu T, Onda T, Sasajima Y, Kato T, Ikeda S, Ishikawa M, Tsuda H: Prognostic significance of positive peritoneal cytology in adenocarcinoma of the uterine cervix. Gynecol Oncol; 2009 Dec;115(3):488-92
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  • [Title] Prognostic significance of positive peritoneal cytology in adenocarcinoma of the uterine cervix.
  • OBJECTIVE: A retrospective analysis was carried out to evaluate the prognostic significance of peritoneal cytology in cervical adenocarcinoma.
  • METHODS: The records of 107 patients with FIGO stage IB to IIB cervical adenocarcinoma who underwent hysterectomy were reviewed.
  • Cox model analysis revealed positive cytology [hazards ratio (HR) 6.27, 95% confidence interval (CI) 2.13-18.41], positive lymph node (HR 6.20, 95% CI 1.87-20.57), ovarian metastasis (HR 5.20, 95% CI 1.18-22.82), and histological grade (HR 5.97, 95% CI 2.00-17.78) to be independent adverse risk factors for survival among the factors analyzed (lymph node status, lymph-vascular space invasion, tumor size, depth in cervical wall, pathological parametrial involvement, infiltration to vagina, ovarian metastasis, and histological grade).
  • CONCLUSION: The presence of positive peritoneal cytology appears to be an independent prognostic risk factor in patients with cervical adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Peritoneal Cavity / pathology. Uterine Cervical Neoplasms / pathology


9. Ozdemir S, Celik C, Gezginç K, Kıreşi D, Esen H: Evaluation of endometrial thickness with transvaginal ultrasonography and histopathology in premenopausal women with abnormal vaginal bleeding. Arch Gynecol Obstet; 2010 Oct;282(4):395-9
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  • [Title] Evaluation of endometrial thickness with transvaginal ultrasonography and histopathology in premenopausal women with abnormal vaginal bleeding.
  • OBJECTIVE: This study was undertaken to investigate cut-off value of the endometrial thickness by transvaginal ultrasonography (TvUSG), and to detect the accuracy of preoperative Pipelle biopsy in premenopausal women with abnormal vaginal bleeding.
  • The abnormal endometrium was composed of 11.8% hyperplasia (simple + atypical complex), 4.2% endometrial polyp, and 5.5% adenocarcinoma.
  • [MeSH-minor] Adult. Female. Humans. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity. Ultrasonography / methods. Vagina / ultrasonography

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  • (PMID = 19921229.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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10. Minoguchi M, Yanagawa N, Ishikawa C, Sasajima J, Goto M, Okamoto M, Saito Y, Murakami M, Orii Y, Yaosaka T: [Pancreatic metastasis of malignant melanoma diagnosed by EUS-guided fine needle aspiration (EUS-FNA)]. Nihon Shokakibyo Gakkai Zasshi; 2007 Jul;104(7):1082-7
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  • Her past medical history included a radical hysterectomy 2 years previously for malignant melanoma of the vagina.
  • Imaging studies including US, CT, and MRI have limited value to distinguish the tumors from primary ductal adenocarcinoma.
  • EUS-FNA can provide tissue diagnosis from pancreatic masses, specifically when other modalities have failed.
  • [MeSH-major] Melanoma / diagnosis. Melanoma / secondary. Pancreas / pathology. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / secondary. Vaginal Neoplasms / pathology

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  • (PMID = 17611386.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. Farah-Klibi F, Kourda-Boujemaa J, Bouaskar I, Dziri C, Rachida Z, Jilani-Baltagi SB: Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature. Pathologica; 2009 Dec;101(6):255-60
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  • [Title] Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature.
  • We present a unique case of primary cystadenocarcinoma of the appendix occurring concurrently with adenocarcinoma of the colon, and overview the clinical and therapeutic difficulties posed by this rare entity.
  • Degenerated adenomatous polyp of the ascending colon and mucinous adenocarcinoma of the sigmoid colon invading the parietal peritoneum of the uterine and vagina was diagnosed.
  • CONCLUSIONS: Preoperative diagnosis of an underlying malignancy in a mucocele is important for patient management, but is difficult to reach by imaging studies alone.
  • Synchronous colon cancer may occur in patients with appendiceal mucoceles.
  • [MeSH-major] Adenocarcinoma / pathology. Appendiceal Neoplasms / pathology. Colonic Neoplasms / pathology. Cystadenocarcinoma / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 20387715.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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12. Takemoto S, Ushijima K, Nakaso K, Fujiyoshi N, Kamura T: Primary adenocarcinoma of the vagina successfully treated with neoadjuvant chemotherapy consisting of paclitaxel and carboplatin. J Obstet Gynaecol Res; 2009 Jun;35(3):579-83
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  • [Title] Primary adenocarcinoma of the vagina successfully treated with neoadjuvant chemotherapy consisting of paclitaxel and carboplatin.
  • Primary vaginal adenocarcinoma unassociated with antenatal diethylstilbestrol (DES) exposure is extremely rare.
  • A 69-year-old woman presented with vaginal bleeding but no history of antenatal DES exposure.
  • She had a solid tumor in the recto-vaginal space, diagnosed as FIGO stage III vaginal adenocarcinoma.
  • Thereafter, radiotherapy was applied to the pelvis and vagina in order to reinforce the state of remission.
  • [MeSH-major] Adenocarcinoma / drug therapy. Carboplatin / administration & dosage. Neoadjuvant Therapy. Paclitaxel / administration & dosage. Vaginal Neoplasms / drug therapy

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  • (PMID = 19527405.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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13. Temkin SM, Hellman M, Lee YC, Abulafia O: Surgical resection of vulvar metastases of endometrial cancer: a presentation of two cases. J Low Genit Tract Dis; 2007 Apr;11(2):118-21
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  • [Title] Surgical resection of vulvar metastases of endometrial cancer: a presentation of two cases.
  • OBJECTIVE: Endometrial cancer generally carries a good prognosis.
  • One half of these recurrences are confined to the vagina.
  • Surgical resection of disease may be possible, therapeutic and even curative, in select patients with isolated cancer recurrence.
  • CASE 1: A 63-year-old patient presented 7 years after treatment of endometrial cancer with a vulvar lesion and groin mass.
  • The lesions were successfully resected and confirmed to be recurrent endometrial cancer.
  • CASE 2: An 83-year-old patient with a history of a hysterectomy for endometrial cancer and radiation therapy for a vaginal vault recurrence presented with an exophytic labial mass.
  • After radical wide excision of her vulvar mass and bilateral groin dissection, final pathology revealed that the mass was consistent with recurrent endometrial cancer.
  • CONCLUSIONS: Uncommon sites of recurrence of endometrial cancer may include the vulva.
  • [MeSH-major] Adenocarcinoma / surgery. Endometrial Neoplasms / pathology. Gynecologic Surgical Procedures. Vulvar Neoplasms / surgery

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  • (PMID = 17415118.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Salvador S, Gilks B, Köbel M, Huntsman D, Rosen B, Miller D: The fallopian tube: primary site of most pelvic high-grade serous carcinomas. Int J Gynecol Cancer; 2009 Jan;19(1):58-64
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  • Epithelial ovarian cancer is the most common cause of mortality from gynecologic malignancy, and most of epithelial cancers are of serous type.
  • Other risk factors for pelvic serous carcinoma will be reviewed, including oral contraceptive use, parity, infertility, and tubal ligation.Studies were identified for this review by searching the English language literature in the MEDLINE database between the years 1995 and 2007 using the following keywords: fallopian tube neoplasia, ovarian serous adenocarcinoma, pregnancy, oral contraceptive, infertility, pelvic inflammatory disease, cytokines, menstruation, and tubal ligation, followed by an extensive review of bibliographies from articles found through the search.The clinical implications of this theory are discussed, and a change in surgical practice is recommended, with salpingectomy at the time of simple hysterectomy.
  • This theory also has implications for the development of new methods of screening for pelvic serous carcinomas, as there are no screening methods that are currently available to find this form of cancer in an early stage.
  • Inflammatory markers could be detected in the vagina from the fallopian tube indicating possible chronic inflammation and a risk factor for mutagenesis leading to serous carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Fallopian Tube Neoplasms / pathology. Neoplasms, Cystic, Mucinous, and Serous / pathology. Ovarian Neoplasms / pathology. Pelvic Neoplasms / pathology

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  • (PMID = 19258943.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal
  • [Number-of-references] 85
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16. Ramsey KH, Sigar IM, Schripsema JH, Denman CJ, Bowlin AK, Myers GA, Rank RG: Strain and virulence diversity in the mouse pathogen Chlamydia muridarum. Infect Immun; 2009 Aug;77(8):3284-93
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  • In vitro, morphometric analysis revealed that the Weiss isolate produced consistently smaller inclusions in human cervical adenocarcinoma cells (HeLa 229) and smaller plaques in monolayers of mouse fibroblasts (L929) than did the Nigg isolate.

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  • (PMID = 19470744.001).
  • [ISSN] 1098-5522
  • [Journal-full-title] Infection and immunity
  • [ISO-abbreviation] Infect. Immun.
  • [Language] ENG
  • [Databank-accession-numbers] GENBANK/ ACOV00000000/ ACOV01000000/ ACOW00000000
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI049354; United States / NIAID NIH HHS / AI / R01 AI059650; United States / NIAID NIH HHS / AI / AI49354; United States / NIAID NIH HHS / AI / AI59650
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Bacterial
  • [Other-IDs] NLM/ PMC2715693
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17. Nasu K, Kai K, Matsumoto H, Mori C, Takai N, Narahara H: Primary mucinous adenocarcinoma of the vagina. Eur J Gynaecol Oncol; 2010;31(6):679-81
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  • [Title] Primary mucinous adenocarcinoma of the vagina.
  • PURPOSE: Primary mucinous adenocarcinoma of the vagina is a rare disease which is characterized by aggressiveness and poor prognosis because of its rapid growth and recurrence, its frequent distant metastases, and its relative resistance to conventional treatment modalities including surgery, radiotherapy, and chemotherapy.
  • We report a case of advanced stage primary mucinous adenocarcinoma of the vagina that showed a highly aggressive course and resistance to combination chemotherapy with paclitaxel and carboplatin.
  • CASE: A 46-year-old multigravid Japanese woman was admitted to our hospital to be treated for Stage IVb primary mucinous adenocarcinoma of the vagina.
  • CONCLUSION: Because of its rarity, little is known about the behavior of primary mucinous adenocarcinoma of the vagina.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / therapy. Vaginal Neoplasms / pathology. Vaginal Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Fatal Outcome. Female. Humans. Middle Aged. Neoplasm Staging. Pelvic Exenteration. Vagina / pathology

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  • (PMID = 21319516.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
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18. Kim MJ, Chung HH, Kim JW, Park NH, Song YS, Kang SB: Uterine corpus involvement as well as histologic type is an independent predictor of ovarian metastasis in uterine cervical cancer. J Gynecol Oncol; 2008 Sep;19(3):181-4
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  • [Title] Uterine corpus involvement as well as histologic type is an independent predictor of ovarian metastasis in uterine cervical cancer.
  • OBJECTIVE: This study aimed to investigate the independent risk factors for ovarian metastasis in cervical cancer.
  • METHODS: Among 1,040 consecutive patients who underwent operation for cervical cancer at our institution from January 1998 to July 2007, a total of 625 patients had both ovaries removed during primary operation were retrospectively selected by medical records.
  • Univariate analysis represents age (</=45 vs. >45 years: p=0.347), histologic types (squamous vs. non-squamous, p<0.0001), FIGO stages (IA1-IIA </=4 cm vs. IB2-IIB >4 cm, p=0.054), stromal invasion (</=1/2 vs. >1/2, p=0.788), lymph node metastasis (positive vs. negative, p=0.007), parametrium (involved vs. uninvolved, p=0.145), upper vagina (involved vs. uninvolved, p=0.003), uterine corpus (involved vs. uninvolved, p<0.0001), and margin status (involved vs. uninvolved, p=0.017).
  • CONCLUSION: Based on our study, uterine involvement of cervical cancer is an independent predictor for ovarian metastasis, except histologic types.
  • Ovarian preservation in cervical cancer may be safely performed only when no involvement of uterine corpus is present.

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  • [Cites] Int J Gynecol Cancer. 2007 May-Jun;17(3):623-8 [17309669.001]
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  • (PMID = 19471574.001).
  • [ISSN] 2005-0380
  • [Journal-full-title] Journal of gynecologic oncology
  • [ISO-abbreviation] J Gynecol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2676471
  • [Keywords] NOTNLM ; Adenocarcinoma / Cervical cancer / Ovarian metastasis / Squamous cell carcinoma
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19. Shepherd ES, Lowe DA, Shepherd JH: Targeted selective trachelo-colpectomy for preservation of fertility in a young woman with vaginal clear cell carcinoma. J Obstet Gynaecol; 2010 May;30(4):420-1
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  • [Title] Targeted selective trachelo-colpectomy for preservation of fertility in a young woman with vaginal clear cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / surgery. Fertility. Vaginal Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Vagina / pathology. Young Adult

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  • (PMID = 20455712.001).
  • [ISSN] 1364-6893
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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20. Mahdavi A, Shamshirsaz AA, Peiretti M, Zakashansky K, Idrees MT, Nezhat F: Laparoscopic management of vaginal clear cell adenocarcinoma arising in pelvic endometriosis: case report and literature review. J Minim Invasive Gynecol; 2006 May-Jun;13(3):237-41
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  • [Title] Laparoscopic management of vaginal clear cell adenocarcinoma arising in pelvic endometriosis: case report and literature review.
  • Vaginal clear cell adenocarcinoma arising from pelvic endometriosis has not been reported in the literature.
  • We report a case of a 50-year-old woman with stage I clear cell adenocarcinoma of the vagina who was found to have endometriosis adjacent to the vaginal tumor.
  • She was treated with neoadjuvant chemoradiation, laparoscopically assisted radical vaginal hysterectomy, radical upper vaginectomy, and pelvic lymphadenectomy followed by combination chemotherapy.
  • [MeSH-major] Adenocarcinoma, Clear Cell / surgery. Endometriosis / complications. Endometriosis / surgery. Vaginal Neoplasms / surgery

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  • (PMID = 16698533.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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21. Bestard Vallejo JE, Orsola de los Santos A, Raventós Busquets CX, Planas Morin J, Morote Robles J: [Closure of a neobladder-vaginal fistula in a patient with Studer's type neobladder using a transvaginal approach with interposition of a Martius' flap]. Arch Esp Urol; 2009 Jan-Feb;62(1):56-9
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  • [Title] [Closure of a neobladder-vaginal fistula in a patient with Studer's type neobladder using a transvaginal approach with interposition of a Martius' flap].
  • [Transliterated title] Cierre de fístula neovésico-vaginal en paciente con neovejiga tipo Studer mediante abordaje transvaginal con interposición de colgajo de Martius.
  • OBJECTIVE: We report a case of neobladder-vaginal fistula in a patient, and its closure using a Martius flap interposition.
  • METHODS: A 51-year-old patient required cystectomy and Studer's neobladder for invasive bladder adenocarcinoma.
  • After urethral catheter removal she presented constant leakage and was diagnosed by cystoscopy of neobladder-vaginal fistula.
  • RESULTS: This complication was successfully treated using a vaginal approach with closure in two layers and interposition of a Martius flap.
  • In our experience and after reviewing literature we think vaginal closure using a Martius flap interposition is a good technique to treat a neobladder-vaginal fistula.
  • [MeSH-major] Postoperative Complications / surgery. Surgical Flaps. Urinary Reservoirs, Continent. Vaginal Fistula / surgery
  • [MeSH-minor] Female. Humans. Middle Aged. Urologic Surgical Procedures / methods. Vagina

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  • (PMID = 19400447.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 10
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22. Renaud MC, Plante M, Grégoire J, Roy M: Primitive clear cell carcinoma of the vagina treated conservatively. J Obstet Gynaecol Can; 2009 Jan;31(1):54-6
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  • [Title] Primitive clear cell carcinoma of the vagina treated conservatively.
  • BACKGROUND: Clear cell adenocarcinoma of the vagina is rare tumour that is usually treated aggressively.
  • We report a case of clear cell adenocarcinoma in which conservative treatment using new technology was successfully completed.
  • CASE: A 19-year-old woman with a biopsy proven clear cell adenocarcinoma of the vagina was referred to our clinic.
  • Colposcopic examination and pelvic MRI confirmed a superficial vaginal lesion.
  • Fertility-sparing surgery, comprising radical local vaginal excision, laparoscopy, sentinel node mapping, pelvic node dissection, and omentectomy, was planned.
  • [MeSH-major] Adenocarcinoma, Clear Cell / surgery. Fertility. Vaginal Neoplasms / surgery

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  • (PMID = 19208284.001).
  • [ISSN] 1701-2163
  • [Journal-full-title] Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC
  • [ISO-abbreviation] J Obstet Gynaecol Can
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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23. Fader AN, Brainard JA, Rose PG: Symptomatic vaginal bleeding in a postmenopausal woman: a case report of pancreatic adenocarcinoma metastasizing exclusively to the vagina. Am J Obstet Gynecol; 2007 Nov;197(5):e8-9
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  • [Title] Symptomatic vaginal bleeding in a postmenopausal woman: a case report of pancreatic adenocarcinoma metastasizing exclusively to the vagina.
  • Although primary vaginal cancer is uncommon, representing 1-2% of all female genital malignancies, metastatic disease to the vagina is not.
  • We present the second case in the literature of a pancreatic adenocarcinoma metastasizing exclusively to the vagina.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Pancreatic Neoplasms / pathology. Uterine Hemorrhage / etiology. Vaginal Neoplasms / complications. Vaginal Neoplasms / secondary

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  • (PMID = 17980174.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Robinson BL, Liao JB, Adams SF, Randall TC: Vaginal cuff dehiscence after robotic total laparoscopic hysterectomy. Obstet Gynecol; 2009 Aug;114(2 Pt 1):369-71
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  • [Title] Vaginal cuff dehiscence after robotic total laparoscopic hysterectomy.
  • BACKGROUND: Vaginal cuff dehiscence with small bowel evisceration after hysterectomy is a rare event that may be occurring more frequently with the advent of robotic laparoscopic hysterectomies.
  • CASES: Two women underwent robotic total laparoscopic hysterectomy for menorrhagia and stage I endocervical adenocarcinoma, respectively.
  • Each presented 7-8 weeks postoperatively with abdominal pain and vaginal pressure after intercourse.
  • The small bowel protruded into the vagina through the dehisced vaginal cuff.
  • CONCLUSION: Robotic total laparoscopic hysterectomy may be associated with increased risk of vaginal cuff dehiscence and small bowel evisceration.

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  • [Cites] Gynecol Oncol. 2002 Jun;85(3):543-4 [12051889.001]
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  • (PMID = 19622999.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA142304-01; United States / NCI NIH HHS / CA / K12 CA076931-12; United States / NCI NIH HHS / CA / L30 CA142304-01; United States / NCI NIH HHS / CA / CA076931-10; United States / NCI NIH HHS / CA / K12 CA076931-10
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS209333; NLM/ PMC2896382
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25. Castilho MS, Jacinto AA, Viani GA, Campana A, Carvalho J, Ferrigno R, Novaes PE, Fogaroli RC, Salvajoli JV: Intensity Modulated Radiotherapy (IMRT) in the postoperative treatment of an adenocarcinoma of the endometrium complicated by a pelvic kidney. Radiat Oncol; 2006;1:44
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  • [Title] Intensity Modulated Radiotherapy (IMRT) in the postoperative treatment of an adenocarcinoma of the endometrium complicated by a pelvic kidney.
  • BACKGROUND: Pelvic Radiotherapy (RT) as a postoperative treatment for endometrial cancer improves local regional control.
  • Brachytherapy also improves vaginal control.
  • CASE: We report on a 50 year-old patient with a serous-papiliferous adenocarcinoma of the uterus who was submitted to surgical treatment without lymph node sampling followed by Brachytherapy, and Chemotherapy.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Endometrial Neoplasms / radiotherapy. Endometrial Neoplasms / surgery. Radiotherapy, Intensity-Modulated / methods
  • [MeSH-minor] Brachytherapy / methods. Female. Humans. Kidney / pathology. Middle Aged. Postoperative Period. Radiotherapy Planning, Computer-Assisted. Treatment Outcome. Vagina / radiation effects

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  • (PMID = 17116263.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1660561
  • [General-notes] NLM/ Original DateCompleted: 20070809
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26. López C, Balogun M, Ganesan R, Olliff JF: MRI of vaginal conditions. Clin Radiol; 2005 Jun;60(6):648-62
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  • [Title] MRI of vaginal conditions.
  • Magnetic resonance imaging (MRI) has become an important part of the assessment of suspected vaginal pathology.
  • This pictorial review demonstrates the MRI features and some of the histopathological findings of a variety of vaginal conditions.
  • These may be congenital (total vaginal agenesis, partial vaginal agenesis, longitudinal vaginal septum, transverse vaginal septum), benign (Bartholin's cyst, diffuse vaginal inflammation, invasive endometriosis, ureterovaginal fistula, post-surgical appearances with the formation of a neovagina and adhesions) or malignant, usually due to extension or recurrence from another pelvic malignancy.
  • In this paper, examples of the above are described and illustrated together with examples of the much rarer primary vaginal malignancies.
  • [MeSH-major] Magnetic Resonance Imaging. Vagina / abnormalities. Vagina / pathology. Vaginal Diseases / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Female. Humans. Middle Aged. Sensitivity and Specificity. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / surgery

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  • (PMID = 16038691.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 27
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27. Reid A, Segal A, Heyworth JS, de Klerk NH, Musk AW: Gynecologic and breast cancers in women after exposure to blue asbestos at Wittenoom. Cancer Epidemiol Biomarkers Prev; 2009 Jan;18(1):140-7
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  • INTRODUCTION: Animal studies have suggested an association between asbestos and ovarian cancer, and asbestos fibers have been detected in human ovaries.
  • Sexual intercourse may introduce asbestos fibers into the vagina and to the cervix and ovaries.
  • RESULTS: Ovarian (standardized incidence ratio, 1.27), cervical (standardized incidence ratio, 1.44), and uterine cancer (standardized incidence ratio, 1.23) increased but not statistically significantly among the Wittenoom women compared with the Western Australian population.
  • Among the Australian Blue Asbestos workers, cervical cancer was twice that of the Western Australian population (standardized incidence ratio, 2.38), but ovarian cancer was less (standardized incidence ratio, 0.65).
  • Women who first arrived at Wittenoom aged >or=40 years had an odds ratio of 13.9 (95% confidence interval, 2.2-90.2) for cervical cancer compared with those aged <15 years at first arrival.
  • [MeSH-minor] Adenocarcinoma / chemically induced. Adenocarcinoma / epidemiology. Adolescent. Adult. Aged, 80 and over. Case-Control Studies. Female. Humans. Incidence. Logistic Models. Western Australia / epidemiology

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  • (PMID = 19124491.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 12001-28-4 / Asbestos, Crocidolite
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28. Yavuz E, Ozlük Y, Küçücük S, Tuzlali S, Akhan SE, Ilhan R, Topuz S, Iplikçi A: Radiation-induced benign glandular cells in posthysterectomy smears: a cytomorphologic and clinical analysis. Int J Gynecol Cancer; 2006 Mar-Apr;16(2):670-4
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  • We reviewed our cytopathology archive material through a 5.5-year period and found 1460 posthysterectomy vaginal smears.
  • Review of this vaginal cytology material revealed 17 posthysterectomy patients whose smears contained BGCs.
  • We concluded that radiation might give rise to a metaplastic process in which basal cells of squamous epithelium of the vagina transform into glandular cells.
  • [MeSH-major] Adenocarcinoma / therapy. Carcinoma, Squamous Cell / therapy. Hysterectomy. Neoplasms, Glandular and Epithelial / pathology. Neoplasms, Radiation-Induced / pathology. Papanicolaou Test. Uterine Cervical Neoplasms / therapy. Vaginal Smears


29. Signorelli M, Lissoni AA, Cormio G, Katsaros D, Pellegrino A, Selvaggi L, Ghezzi F, Scambia G, Zola P, Grassi R, Milani R, Giannice R, Caspani G, Mangioni C, Floriani I, Rulli E, Fossati R: Modified radical hysterectomy versus extrafascial hysterectomy in the treatment of stage I endometrial cancer: results from the ILIADE randomized study. Ann Surg Oncol; 2009 Dec;16(12):3431-41
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  • [Title] Modified radical hysterectomy versus extrafascial hysterectomy in the treatment of stage I endometrial cancer: results from the ILIADE randomized study.
  • BACKGROUND: Five percent to 20% of stage I endometrial cancer patients undergoing total abdominal hysterectomy and bilateral salpingo-oophorectomy develop vaginal and pelvic recurrences.
  • METHODS: Eligible patients (n = 520) with stage I endometrial cancer were randomized to class I or class II hysterectomy.
  • RESULTS: The median length of parametria and vagina removed were 15 and 5 vs. 20 mm and 15 mm for class I and class II hysterectomy, respectively (P > 0.001).
  • CONCLUSIONS: Class II hysterectomy did not improve locoregional control and survival compared to class I hysterectomy, but when an adequate vaginal cuff transection is not feasible with class I hysterectomy, a modified radical hysterectomy allows to obtain an optimal vaginal and pelvic control of disease with a minimal increase in surgical morbidity.
  • [MeSH-major] Adenocarcinoma, Clear Cell / surgery. Adenocarcinoma, Mucinous / surgery. Carcinoma, Adenosquamous / surgery. Cystadenocarcinoma, Serous / surgery. Endometrial Neoplasms / surgery. Hysterectomy / methods

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  • (PMID = 19834767.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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30. Saitoh M, Hayasaka T, Ohmichi M, Kurachi H, Motoyama T: Primary mucinous adenocarcinoma of the vagina: possibility of differentiating from metastatic adenocarcinomas. Pathol Int; 2005 Jun;55(6):372-5
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  • [Title] Primary mucinous adenocarcinoma of the vagina: possibility of differentiating from metastatic adenocarcinomas.
  • Primary vaginal adenocarcinomas are rare neoplasms.
  • Herein is reported a case of primary vaginal mucinous adenocarcinoma with an interesting mucin profile, presumably arising from a lesion of adenosis in a patient without in utero exposure to diethylstilbesterol (DES).
  • The patient, a 44-year-old woman, had undergone vaginal total hysterectomy 10 years previously for myoma uteri corporis.
  • The histological features of the vaginal intramural tumor found in this patient resembled those of mucinous adenocarcinoma of the endocervical type.
  • Therefore, it was necessary to determine whether or not the tumor was metastatic from an occult cervical adenocarcinoma.
  • However, the adenocarcinoma cells of the present case did not contain sulfomucin at all, being different from most mucinous adenocarcinoma cells of the endocervical type.
  • Moreover, there were foci of adenosis adjacent to the adenocarcinoma foci, which also did not contain sulfomucin.
  • These findings indicate that the mucinous adenocarcinoma arose from vaginal adenosis.
  • Further studies are necessary to investigate whether lack of sulfomucin expression is a characteristic feature of vaginal adenosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Vaginal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Mucin 5AC. Mucin-1 / analysis. Mucin-2. Mucin-6. Mucins / analysis. Neoplasm Metastasis. Vagina / chemistry. Vagina / pathology

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  • (PMID = 15943796.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucin-6; 0 / Mucins
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31. Liguori G, Amodeo A, Mucelli FP, Patel H, Marco D, Belgrano E, Trombetta C: Intractable haematuria: long-term results after selective embolization of the internal iliac arteries. BJU Int; 2010 Aug;106(4):500-3
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  • Twenty-four patients had transitional carcinoma of the urinary bladder, 12 adenocarcinoma of the prostate, five carcinoma of the uterus, one cancer of the vagina, two carcinoma of the rectum, three carcinoma of the kidney, two simultaneous carcinoma of prostate and bladder, one simultaneous carcinoma of prostate and kidney and one had haemorrhagic cystitis after radiotherapy.

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  • (PMID = 20128777.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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32. Fakiris AJ, Henderson M, Lo SS, Look KY, Cardenes HR: Intraperitoneal radioactive phosphorus (32P) and vaginal brachytherapy as adjuvant treatment for uterine papillary serous carcinoma and clear cell carcinoma: the Indiana University experience. Brachytherapy; 2010 Jan-Mar;9(1):61-5
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  • [Title] Intraperitoneal radioactive phosphorus (32P) and vaginal brachytherapy as adjuvant treatment for uterine papillary serous carcinoma and clear cell carcinoma: the Indiana University experience.
  • PURPOSE: To evaluate the outcomes of surgically staged patients with Stage I-IIIA uterine papillary serous carcinoma (UPSC) and clear cell carcinoma (CCC) of the uterus treated at Indiana University with intraperitoneal (32)P and vaginal brachytherapy.
  • Subsequently, high dose rate (HDR) vaginal cuff brachytherapy was delivered to a total dose of 2100 cGy in three fractions prescribed to 0.5 cm depth.
  • RESULTS: Intraperitoneal (32)P was administered at a median of 4 weeks from surgery, followed by vaginal brachytherapy.
  • There were 4 patients with recurrent disease: 2 initially relapsed intraperitoneally, 1 in the distal vagina, and 1 had a scar recurrence.
  • CONCLUSIONS: Adjuvant therapy for UPSC and CCC with intraperitoneal (32)P and vaginal brachytherapy after adequate surgical staging and maximal cytoreduction is well tolerated and appears to be effective.
  • [MeSH-major] Adenocarcinoma, Clear Cell / radiotherapy. Brachytherapy / methods. Carcinoma, Papillary / radiotherapy. Phosphorus Radioisotopes / administration & dosage. Uterine Neoplasms / radiotherapy

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  • [Copyright] Copyright (c) 2010 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20129252.001).
  • [ISSN] 1873-1449
  • [Journal-full-title] Brachytherapy
  • [ISO-abbreviation] Brachytherapy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Phosphorus Radioisotopes; 0 / Radiopharmaceuticals
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33. Shah C, Pizer E, Veljovich DS, Drescher CW, Peters WA 3rd, Paley PJ: Clear cell adenocarcinoma of the vagina in a patient with vaginal endometriosis. Gynecol Oncol; 2006 Dec;103(3):1130-2
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  • [Title] Clear cell adenocarcinoma of the vagina in a patient with vaginal endometriosis.
  • Physical examination revealed a 2-cm polypoid lesion at the posterior vaginal apex, which was found to be a moderately differentiated invasive adenocarcinoma.
  • Final pathology at the time of definitive surgery demonstrated a clear cell adenocarcinoma of the vagina arising in vaginal endometriosis.
  • CONCLUSION: Vaginal endometriosis may lead to the development of cancer.
  • We report a case of clear cell malignancy arising in vaginal endometriosis, adding to only seven cases previously reported.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Endometriosis / diagnosis. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged


34. Kwon YS, Nam JH, Choi G: Clear cell adenocarcinoma arising in endometriosis of a previous episiotomy site. Obstet Gynecol; 2008 Aug;112(2 Pt 2):475-7
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  • [Title] Clear cell adenocarcinoma arising in endometriosis of a previous episiotomy site.
  • CASE: A 42-year-old woman presented with a palpable mass, 2.5 cm in size, just inside the posterior commissure of the vagina, at the site of a previous episiotomy for a vaginal delivery.
  • Biopsy revealed a clear cell adenocarcinoma arising in endometriosis.
  • [MeSH-major] Adenocarcinoma, Clear Cell / etiology. Endometriosis / complications. Episiotomy / adverse effects. Iatrogenic Disease. Vulvar Neoplasms / etiology

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  • (PMID = 18669770.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Nishiyama S, Okudaira M, Saito N: Mechanisms of rolipram-induced increase in the incidence of mammary adenocarcinoma: histopathological study of a 104-week oral carcinogenicity study in female Sprague-Dawley rats. Arch Toxicol; 2006 Feb;80(2):88-97
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  • [Title] Mechanisms of rolipram-induced increase in the incidence of mammary adenocarcinoma: histopathological study of a 104-week oral carcinogenicity study in female Sprague-Dawley rats.
  • To clarify the mechanisms behind a rolipram-induced increase in the incidence of mammary adenocarcinoma at time points earlier than 104 weeks, the hormonal changes associated with pituitary adenoma were identified, and estrous cycling in the ovary, uterus, and vagina were examined in female rats treated with rolipram for 52 weeks.
  • Changes in estrous cycling in the uterus and vagina and a decrease in the size and number of corpora lutea in the ovaries of female rats treated with rolipram at 2.0 mg/kg for 52 weeks indicated that an increase in the estrus phase of the cycle corresponded to a marked decrease in the diestrus phase, which might result from the increased plasma estrogen concentration.
  • [MeSH-major] Adenocarcinoma / chemically induced. Mammary Neoplasms, Experimental / chemically induced. Phosphodiesterase Inhibitors / toxicity. Pituitary Neoplasms / chemically induced. Prolactinoma / chemically induced. Rolipram / toxicity

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  • (PMID = 16167140.001).
  • [ISSN] 0340-5761
  • [Journal-full-title] Archives of toxicology
  • [ISO-abbreviation] Arch. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Phosphodiesterase Inhibitors; 4TI98Z838E / Estradiol; 9002-62-4 / Prolactin; K676NL63N7 / Rolipram
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36. Sutton G, Axelrod JH, Bundy BN, Roy T, Homesley H, Lee RB, Gehrig PA, Zaino R: Adjuvant whole abdominal irradiation in clinical stages I and II papillary serous or clear cell carcinoma of the endometrium: a phase II study of the Gynecologic Oncology Group. Gynecol Oncol; 2006 Feb;100(2):349-54
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  • RESULTS: Among 21 PS patients (median age: 68 years), one refused therapy, and another received a non-protocol vaginal boost.
  • Among treated patients who DOD, sites of recurrence included lung (2), lung/vagina (1), abdomen/pelvis (1), vagina (1), and abdomen (2).
  • Among patients who DOD, sites of recurrence included lung (1), vagina (1), and unknown (1).
  • [MeSH-major] Adenocarcinoma, Clear Cell / radiotherapy. Carcinoma, Papillary / radiotherapy. Cystadenocarcinoma, Serous / radiotherapy. Endometrial Neoplasms / radiotherapy

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  • (PMID = 16213007.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 12477; United States / NCI NIH HHS / CA / CA 12482; United States / NCI NIH HHS / CA / CA 12484; United States / NCI NIH HHS / CA / CA 12534; United States / NCI NIH HHS / CA / CA 13630; United States / NCI NIH HHS / CA / CA 13633; United States / NCI NIH HHS / CA / CA 15975; United States / NCI NIH HHS / CA / CA 16386; United States / NCI NIH HHS / CA / CA 16938; United States / NCI NIH HHS / CA / CA 21720; United States / NCI NIH HHS / CA / CA 21946; United States / NCI NIH HHS / CA / CA 23073; United States / NCI NIH HHS / CA / CA 23501; United States / NCI NIH HHS / CA / CA 23765; United States / NCI NIH HHS / CA / CA 27469; United States / NCI NIH HHS / CA / CA 28160; United States / NCI NIH HHS / CA / CA 34477; United States / NCI NIH HHS / CA / CA 35640; United States / NCI NIH HHS / CA / CA 37535; United States / NCI NIH HHS / CA / CA 37569; United States / NCI NIH HHS / CA / CA 40296
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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37. Silva EG, Deavers MT, Bodurka DC, Malpica A: Association of low-grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: a new type of dedifferentiated carcinoma? Int J Gynecol Pathol; 2006 Jan;25(1):52-8
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  • At presentation, the patients had either vaginal bleeding or pelvic pain.
  • Undifferentiated carcinoma was found after resection of low-grade endometrioid carcinoma in six cases, involving the retroperitoneum, pelvis, vagina, or liver.
  • In four cases, the diagnosis was made recently, with short follow-ups of 3 and 4 months.
  • Foci of undifferentiated carcinoma may be confused with solid endometrioid adenocarcinoma erroneously leading to the diagnosis of a grade 3 or a significantly less aggressive grade 2 endometrioid carcinoma.
  • The recognition of undifferentiated carcinoma in an otherwise low-grade endometrioid adenocarcinoma is extremely important because it indicates aggressive behavior.

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  • [ErratumIn] Int J Gynecol Pathol. 2006 Jul;25(3):304
  • (PMID = 16306785.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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38. Cao L, Li X, Zhang Y, Li X, Wang Q: [Clinical features and prognosis of cervical cancer in young women]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2010 Aug;35(8):875-8
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  • [Title] [Clinical features and prognosis of cervical cancer in young women].
  • OBJECTIVE: To investigate the prevalence, etiology, clinical presentation and pathological features, treatment and prognosis of cervical cancer in young women.
  • METHODS: Clinical data of 132 young women with cervical cancer were reviewed.
  • RESULTS: Positive rate of human papillomavirus 18 was high in young women with cervical cancer.
  • The primary clinical presentation of young patients with cervical cancer was contact bleeding of vagina, and the signs were out-expanding of cervical mass.
  • The percentage of adenocarcinoma increased.
  • The main treatment for cervical cancer was surgery.
  • CONCLUSION: Contact bleeding is a significant symptom in young women with cervical cancer.
  • Preoperative neoadjuvant chemotherapy can be used in patients with locally advanced and late stage cervical cancer.
  • [MeSH-major] Uterine Cervical Neoplasms / diagnosis


39. Parikh JH, Barton DP, Ind TE, Sohaib SA: MR imaging features of vaginal malignancies. Radiographics; 2008 Jan-Feb;28(1):49-63; quiz 322
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  • [Title] MR imaging features of vaginal malignancies.
  • Primary vaginal malignancies are rare, accounting for only 1%-2% of all gynecologic malignancies.
  • Squamous cell carcinoma makes up about 85% of primary vaginal malignancies.
  • This tumor characteristically arises from the posterior wall of the upper third of the vagina.
  • The tumors that account for the remaining 15% of primary vaginal malignancies are adenocarcinoma, melanoma, and sarcomas.
  • Secondary malignancy of the vagina is far more frequent than primary vaginal malignancy.
  • Most vaginal metastases occur by means of direct local spread from the cervix, uterus, or rectum.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Image Enhancement / methods. Magnetic Resonance Imaging / methods. Vagina / pathology. Vaginal Neoplasms / diagnosis

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  • (PMID = 18203930.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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40. Romero FR, Fucs M, Castro MG, Garcia CR, Fernandes Rde C, Perez MD: Adenocarcinoma of persistent müllerian duct remnants: case report and differential diagnosis. Urology; 2005 Jul;66(1):194-5
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  • [Title] Adenocarcinoma of persistent müllerian duct remnants: case report and differential diagnosis.
  • Persistent müllerian duct syndrome is an unusual disorder characterized by cryptorchidism and retention of müllerian derivatives (uterus, fallopian tubes, and upper vagina).
  • We report the case of a 39-year-old man with this syndrome in association with adenocarcinoma from the retained müllerian remnants of probable endocervical origin.
  • To our knowledge, this is the first report of an endocervical adenocarcinoma associated with persistent müllerian duct syndrome.
  • [MeSH-major] Adenocarcinoma / complications. Cryptorchidism / complications. Mullerian Ducts / abnormalities
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 16009404.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Wani Y, Notohara K, Tsukayama C: Mesonephric adenocarcinoma of the uterine corpus: a case report and review of the literature. Int J Gynecol Pathol; 2008 Jul;27(3):346-52
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  • [Title] Mesonephric adenocarcinoma of the uterine corpus: a case report and review of the literature.
  • Mesonephric adenocarcinoma (MA) is a rare tumor of the female genital tract, mainly in the cervix and vagina, which is usually associated with mesonephric remnants or mesonephric hyperplasia.
  • In addition, the ductal pattern simulating endometrioid adenocarcinoma was also noted.
  • Other elements consisted of a retiform pattern, serous adenocarcinoma-like papillary budding, and glomeruloid morphology.
  • We review the previously published cases of MA and discuss the principal differential diagnosis of MA in the uterine corpus.
  • [MeSH-major] Adenocarcinoma / pathology. Uterine Neoplasms / pathology

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  • (PMID = 18580312.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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42. Kim S, Wu HG, Lee HP, Kang SB, Song YS, Park NH, Ha SW: Patterns of failure after postoperative radiation therapy for endometrial carcinoma. Cancer Res Treat; 2006;38(3):133-8
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  • PURPOSE: We tried to investigate the outcome and patterns of failure of endometrial cancer patients who were treated with surgery and postoperative radiation therapy (RT).
  • MATERIALS AND METHODS: Eighty-three patients with endometrial cancer who received postoperative RT between May 1979 and August 2000 were included in this retrospective study.
  • Forty-one patients received total abdominal hysterectomy, 41 patients received Wertheim's operation and 1 underwent vaginal hysterectomy.
  • The histologic diagnoses were adenocarcinoma in seventy-four patients (89%).
  • A total dose of 7,500 approximately 9,540 cGy (median dose: 8511) was prescribed to the vaginal surface.
  • Among the 54 stage I or II patients, 1 (2%) relapsed in the pelvis only, 2 (4%) relapsed in the vagina and distant organs, and 1 (2%) relapsed in the paraaortic lymph nodes (PANs).
  • Among the 29 stage III patients, 1 (3%) relapsed in the vagina.

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  • [Keywords] NOTNLM ; Endometrial neoplasms / Patterns of failure / Postoperative radiation therapy
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43. García Flórez LJ, Argüelles J, Quijada B, Alvarez V, Galarraga MA, Graña JL: Transvaginal specimen extraction in a laparoscopic anterior resection of a sigmoid colon neoplasia with en bloc right salpingo-oophorectomy. Tech Coloproctol; 2010 Jun;14(2):161-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / surgery. Colectomy / methods. Laparoscopy. Ovariectomy. Salpingostomy. Sigmoid Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Vagina

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  • (PMID = 20135188.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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44. Abu-Rustum NR, Su W, Levine DA, Boyd J, Sonoda Y, Laquaglia MP: Pediatric radical abdominal trachelectomy for cervical clear cell carcinoma: a novel surgical approach. Gynecol Oncol; 2005 Apr;97(1):296-300
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  • INTRODUCTION: Clear cell carcinoma of the cervix and vagina is rare in the pediatric population.
  • Radical abdominal or vaginal trachelectomy and pelvic lymph node dissection is a new technique utilized in adult women with early cervical cancer who wish to retain fertility.
  • METHODS: Due to the narrow vaginal anatomy in pediatric patients, a vaginal approach is not possible, and an abdominal approach is performed.
  • The resection includes the cervix, upper vagina, parametrium, and paracolpos.
  • RESULTS: Two girls aged 6 and 8 years and without history of DES exposure presented with vaginal bleeding.
  • Biopsies demonstrated clear cell cancer stage IB1 in both patients.
  • They underwent radical abdominal trachelectomy and bilateral pelvic lymph node dissection along with anastomosis of uterine isthmus to upper vagina.
  • Intraoperative frozen-section analysis confirmed negative uterine and vaginal margins.
  • [MeSH-major] Adenocarcinoma, Clear Cell / surgery. Gynecologic Surgical Procedures / methods. Uterine Cervical Neoplasms / surgery

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  • (PMID = 15790482.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Simon J, Nachtigall L, Ulrich LG, Eugster-Hausmann M, Gut R: Endometrial safety of ultra-low-dose estradiol vaginal tablets. Obstet Gynecol; 2010 Oct;116(4):876-83
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  • [Title] Endometrial safety of ultra-low-dose estradiol vaginal tablets.
  • OBJECTIVE: To evaluate the endometrial hyperplasia and carcinoma rate after 52-week treatment with ultra-low-dose 10-microgram 17β-estradiol vaginal tablets in postmenopausal women with vaginal atrophy.
  • Patients received 10-microgram estradiol vaginal tablets for 52 weeks.
  • One woman's biopsy sample demonstrated endometrioid adenocarcinoma, grade 2, but the lack of an evaluable screening biopsy sample makes it uncertain whether the carcinoma was preexisting.
  • The results of this pooled analysis therefore support the endometrial safety of unopposed ultra-low-dose vaginal estrogen.
  • There was no increased risk of endometrial hyperplasia and carcinoma in postmenopausal women undergoing treatment with 10-microgram estradiol vaginal tablets for 1 year under study conditions.
  • [MeSH-minor] Atrophy. Double-Blind Method. Female. Humans. Middle Aged. Patient Selection. Vagina / pathology. Vaginal Creams, Foams, and Jellies

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  • (PMID = 20859151.001).
  • [ISSN] 1873-233X
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00108849/ NCT00431132
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens; 0 / Vaginal Creams, Foams, and Jellies; 4TI98Z838E / Estradiol
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46. Myriokefalitaki E, Iavazzo C, Vorgias G, Akrivos T: A two eterochronous primary gynaecological malignancies of different origin. Bratisl Lek Listy; 2009;110(11):726-8
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  • CASE: A 65-year-old para-2, white obese female, presented in our department 4 years ago, due to a single event of vaginal spotting.
  • Curettage revealed an endometrial cancer.
  • Histology showed an endometrioid adenocarcinoma of endometrium stage Ib, moderately differentiated.
  • Although, recurrence on vaginal cuff was possible, the biopsies of anterior vaginal wall showed a poorly differentiated squamous cell carcinoma of the vagina.
  • The patient was classified as stage II vaginal carcinoma and underwent complete radiotherapy and chemotherapy.
  • [MeSH-major] Carcinoma, Endometrioid / diagnosis. Carcinoma, Squamous Cell / diagnosis. Endometrial Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Vaginal Neoplasms / diagnosis

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  • (PMID = 20120445.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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47. Lilic V, Lilic G, Filipovic S, Visnjic M, Zivadinovic R: Primary carcinoma of the vagina. J BUON; 2010 Apr-Jun;15(2):241-7
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  • [Title] Primary carcinoma of the vagina.
  • In this paper we reviewed the risk factors for primary carcinoma of the vagina (PCV), diagnostic and therapeutic modalities, and principles leading to rational decision-making in the individualized management of vaginal carcinoma patients.
  • Histopathologically, most common are squamous cell carcinoma (80-90%) and adenocarcinoma (4-10%).
  • The leading risk factor for vaginal intraepithelial neoplasia (VAIN) and subsequent squamous cell vaginal carcinoma is long-lasting infection with human papillomavirus (HPV) type 16.
  • In most centres, standard treatment for this cancer is radiotherapy.
  • The supposed advantage of radiotherapy is the preservation of the anatomy and function of the vagina.
  • We believe that there are certain psychologic benefits with the preservation of the vagina, regardless of its function.
  • However, preservation of the vaginal function after treatment of invasive vaginal cancer is a rare phenomenon, both in the literature and from our own experience.
  • [MeSH-major] Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / epidemiology

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  • (PMID = 20658716.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Number-of-references] 45
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48. Kobayashi H, Sumimoto K, Kitanaka T, Yamada Y, Sado T, Sakata M, Yoshida S, Kawaguchi R, Kanayama S, Shigetomi H, Haruta S, Tsuji Y, Ueda S, Terao T: Ovarian endometrioma--risks factors of ovarian cancer development. Eur J Obstet Gynecol Reprod Biol; 2008 Jun;138(2):187-93
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  • [Title] Ovarian endometrioma--risks factors of ovarian cancer development.
  • OBJECTIVE: Our prospective studies in Japan have found an increased ovarian cancer incidence in women with ovarian endometrioma (standardized incidence ratio, 8.95; 95% confidence intervals, 4.12-5.3).
  • The risk increased with increasing age at ovarian endometrioma diagnosis.
  • The goal of this study was to define the risk factor(s) of ovarian cancer development in a Japanese population with ovarian endometrioma.
  • We also analyzed whether the predisposition toward ovarian cancer is limited to endometrioid and clear cell carcinoma.
  • STUDY DESIGN: A total of 6398 participants at 212 participating hospitals in Shizuoka, Japan, were enrolled in the Shizuoka Cohort Study on Endometriosis and Ovarian Cancer (SCSEOC) Trial, which had prospective and retrospective components.
  • The risks of development of ovarian cancer were assessed in 6398 women with ultrasonographically diagnosed ovarian endometriomas.
  • Cox proportional-hazards regression function was used to estimate impact in terms of risk factors and possible development of ovarian cancer.
  • RESULTS: The prospective study demonstrated that 46 (0.72%) of 6398 women developed histologically proven ovarian cancer and were operated upon during follow-up.
  • Clear cell carcinoma (39%) and endometrioid adenocarcinoma (35%) were commonly observed among women with ovarian cancer.
  • By multivariate analysis, tumor size > or =9 cm in diameter and postmenopausal women were independent predictive factors of patients with development of ovarian cancer.
  • Advancing age and the size of endometriomas were independent predictors of development of ovarian cancer among women with ovarian endometrioma.
  • [MeSH-minor] Adult. Female. Humans. Menopause. Middle Aged. Proportional Hazards Models. Prospective Studies. Risk Factors. Vagina / ultrasonography

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  • (PMID = 18162283.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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49. Hanifi-Moghaddam P, Gielen SC, Kloosterboer HJ, De Gooyer ME, Sijbers AM, van Gool AJ, Smid M, Moorhouse M, van Wijk FH, Burger CW, Blok LJ: Molecular portrait of the progestagenic and estrogenic actions of tibolone: behavior of cellular networks in response to tibolone. J Clin Endocrinol Metab; 2005 Feb;90(2):973-83
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  • Tibolone is a synthetic steroid with estrogenic effects on brain, vagina, and bone without stimulating the endometrium.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Cell Differentiation / drug effects. Cell Division / drug effects. Cell Line, Tumor. Endometrial Neoplasms / genetics. Endometrial Neoplasms / pathology. Estradiol / pharmacology. Female. Gene Expression Profiling. Humans. Nerve Net. Transcription, Genetic / drug effects

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  • (PMID = 15572424.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor Modulators; 0 / Norpregnenes; 0 / Progestins; 4TI98Z838E / Estradiol; FF9X0205V2 / tibolone
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50. Chen Y, Xu H, Zhang Q, Li Y, Wang D, Liang Z: A fertility-preserving option in early cervical carcinoma: laparoscopy-assisted vaginal radical trachelectomy and pelvic lymphadenectomy. Eur J Obstet Gynecol Reprod Biol; 2008 Jan;136(1):90-3
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  • [Title] A fertility-preserving option in early cervical carcinoma: laparoscopy-assisted vaginal radical trachelectomy and pelvic lymphadenectomy.
  • OBJECTIVE: Laparoscopic vaginal radical trachelectomy is a fertility-preserving alternative to radical hysterectomy or chemoradiation in young women with stage IA2 to IB cervical cancers.
  • The aim of this study is to describe the feasibility and outcome of laparoscopic radical vaginal trachelectomy and pelvic lymphadenectomy in women treated with early cervical cancers who wish to maintain fertility.
  • Vaginal radical trachelectomy was performed immediately if removed lymph nodes were negative.
  • CONCLUSIONS: Laparoscopy-assisted radical vaginal trachelectomy is an adequate treatment, with its minimally invasive procedure and shorter recovery time, for early-stage cervical cancer in women who wish to preserve fertility.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Gynecologic Surgical Procedures / methods. Lymph Node Excision. Uterine Cervical Neoplasms / surgery
  • [MeSH-minor] Adult. Cervix Uteri / surgery. Female. Fertility. Follow-Up Studies. Humans. Laparoscopy. Neoplasm Staging. Pelvis. Pregnancy. Vagina / surgery

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  • (PMID = 17137704.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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51. van der Aa MA, Helmerhorst TJ, Siesling S, Riemersma S, Coebergh JW: Vaginal and (uncommon) cervical cancers in the Netherlands, 1989-2003. Int J Gynecol Cancer; 2010 May;20(4):638-45
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  • [Title] Vaginal and (uncommon) cervical cancers in the Netherlands, 1989-2003.
  • BACKGROUND: The clinical and prognostic evaluation of cervical and vaginal tumors other than squamous cell and adenocarcinomas is hampered by the low incidence, and clinical and epidemiological studies on these uncommon tumors are scarce.
  • Having close affinity with the pathology laboratories, the Netherlands Cancer Registry offers a great opportunity to study frequency, stage, treatment, and survival of uncommon tumors in the cervix and vagina and separately, the clear cell adenocarcinoma of the vagina and cervix.
  • METHODS: All invasive cervical tumors (n = 10,570) and all in situ and invasive vaginal tumors (n = 778) diagnosed in the Netherlands during 1989-2003 were selected from the Netherlands Cancer Registry.
  • Age, stage at diagnosis, and treatment were described for each histological subgroup to find differences between common and uncommon tumors, including 5-year relative survival rates.
  • RESULTS: Twenty-five patients (3%) with cervical cancer subsequently developed a vaginal tumor (during 1989-2003), and 19 of these patients underwent hysterectomy for their cervical cancer.
  • A significantly worse prognosis was found for patients with small cell neuroendocrine cervical tumors and for patients with vaginal melanomas.
  • Patients with clear cell adenocarcinoma of the vagina and cervix were found across all age categories.
  • CONCLUSIONS: The less common histological types of cervical and vaginal cancers were clearly different from squamous cell carcinomas, especially with respect to age at diagnosis and survival rates.
  • [MeSH-major] Adenocarcinoma / mortality. Carcinoma, Squamous Cell / mortality. Neoplasms, Glandular and Epithelial / mortality. Uterine Cervical Neoplasms / mortality. Vaginal Neoplasms / mortality


52. Goker BO, Bese T, Ilvan S, Yilmaz E, Demirkiran F: A case with multiple gynecological malignancies. Int J Gynecol Cancer; 2005 Mar-Apr;15(2):372-6
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  • Fourteen months after the diagnosis of the lymphoma, an endometrial adenocarcinoma was detected as a secondary malignant tumor.
  • Approximately 7 years after the diagnosis of endometrial cancer, vaginal invasive squamous cell carcinoma was diagnosed as the third primary malignancy, and a second-line palliative radiotherapy was applied.
  • Seven months after the last radiotherapy, postradiational sarcoma in the vagina was diagnosed.
  • [MeSH-major] Adenocarcinoma / pathology. Endometrial Neoplasms / pathology. Lymphoma, Non-Hodgkin / drug therapy. Neoplasms, Multiple Primary / pathology. Sarcoma / pathology. Uterine Cervical Neoplasms / drug therapy. Vaginal Neoplasms / pathology


53. Amant F, Cadron I, Fuso L, Berteloot P, de Jonge E, Jacomen G, Van Robaeys J, Neven P, Moerman P, Vergote I: Endometrial carcinosarcomas have a different prognosis and pattern of spread compared to high-risk epithelial endometrial cancer. Gynecol Oncol; 2005 Aug;98(2):274-80
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  • [Title] Endometrial carcinosarcomas have a different prognosis and pattern of spread compared to high-risk epithelial endometrial cancer.
  • The current study investigates whether uterine carcinosarcomas can be included in protocols on high-risk endometrial cancer, given the similarities in biologic behavior of both entities.
  • METHODS: Pathological and surgical notes of patients diagnosed with grade 3 endometrioid, carcinosarcoma, serous and clear cell endometrial cancer subtypes were retrospectively analyzed with special attention to the spread pattern of the different subtypes.
  • Analyzing cases limited to stage I-II endometrial cancer, 24/28 (86%) grade 3 endometrioid, 18/24 (75%) non-endometrioid, and 11/25 (44%) carcinosarcomas survived, suggesting a worse outcome for endometrial carcinosarcoma when compared to the other subtypes (P < 0.008, Log Rank).
  • A higher incidence of pulmonary metastases explained the worse outcome for early stage carcinosarcoma (P < 0.006), whereas the incidence of liver metastasis, transperitoneal spread, or recurrences in lymph nodes or vagina were comparable between the three pathologic subtypes.
  • CONCLUSIONS: Although endometrial carcinosarcoma originates from epithelial cancer, the intrinsic more aggressive tumor biology suggests that this subtype should not be incorporated in studies on high-risk epithelial endometrial cancer.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Endometrioid / pathology. Carcinosarcoma / pathology. Cystadenocarcinoma, Serous / pathology. Endometrial Neoplasms / pathology

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  • (PMID = 15972232.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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54. Sohaib SA, Houghton SL, Meroni R, Rockall AG, Blake P, Reznek RH: Recurrent endometrial cancer: patterns of recurrent disease and assessment of prognosis. Clin Radiol; 2007 Jan;62(1):28-34; discussion 35-6
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  • [Title] Recurrent endometrial cancer: patterns of recurrent disease and assessment of prognosis.
  • AIM: To evaluate patterns of disease and identify factors predicting outcome in patients presenting with recurrent endometrial adenocarcinoma following primary surgery.
  • MATERIALS AND METHODS: A retrospective review was performed of the imaging and clinical data in 86 patients (median age 66 years, range 42-88 years) presenting with recurrent endometrial adenocarcinoma following primary surgery.
  • Relapse was seen within lymph nodes in 41 (46%), the vagina in 36 (42%) the peritoneum in 24 (28%) and the lung in 21 (24%).
  • The presence of disease within the vagina, bladder or lung was not associated with poor prognosis.
  • CONCLUSION: The most frequently observed sites of relapse are: lymph nodes, vagina, peritoneum and lung.
  • [MeSH-major] Adenocarcinoma / radiography. Endometrial Neoplasms / radiography. Neoplasm Recurrence, Local / radiography. Neoplasms, Multiple Primary / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Hysterectomy. Liver Neoplasms / radiography. Liver Neoplasms / secondary. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Lymphatic Metastasis. Middle Aged. Multivariate Analysis. Neoplasm Staging. Peritoneal Neoplasms / radiography. Peritoneal Neoplasms / secondary. Prognosis. Retrospective Studies. Splenic Neoplasms / radiography. Splenic Neoplasms / secondary. Vaginal Neoplasms / radiography. Vaginal Neoplasms / secondary

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  • (PMID = 17145260.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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56. Hajek RA, King DW, Hernández-Valero MA, Kaufman RH, Liang JC, Chilton JA, Edwards CL, Wharton JT, Jones LA: Detection of chromosomal aberrations by fluorescence in situ hybridization in cervicovaginal biopsies from women exposed to diethylstilbestrol in utero. Int J Gynecol Cancer; 2006 Jan-Feb;16(1):318-24
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  • Epidemiologic studies have associated estrogens with human neoplasms such as those in the endometrium, cervix, vagina, breast, and liver.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / chemically induced. Adenocarcinoma, Clear Cell / epidemiology. Adenocarcinoma, Clear Cell / pathology. Adult. Biopsy, Needle. Case-Control Studies. Female. Humans. In Situ Hybridization, Fluorescence. Incidence. Probability. Reference Values. Risk Assessment. Sensitivity and Specificity. Tissue Culture Techniques. Uterine Cervical Neoplasms / chemically induced. Uterine Cervical Neoplasms / epidemiology. Uterine Cervical Neoplasms / pathology. Vaginal Neoplasms / chemically induced. Vaginal Neoplasms / epidemiology. Vaginal Neoplasms / pathology

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  • (PMID = 16445652.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA 16672; United States / NIMHD NIH HHS / MD / P60 MD 00503; United States / NCI NIH HHS / CA / R01 CA 44591; United States / NCI NIH HHS / CA / R01 CA 69375A-05S4; United States / NICHD NIH HHS / HD / T32 HD 07324; United States / ODCDC CDC HHS / CC / U48 CCU 619515-01
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 731DCA35BT / Diethylstilbestrol
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57. Veurink M, Koster M, Berg LT: The history of DES, lessons to be learned. Pharm World Sci; 2005 Jun;27(3):139-43
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  • DES is now associated with an increased risk of breast cancer, clear cell adenocarcinoma (CCAC) of the vagina and cervix, and reproductive anomalies.

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  • (PMID = 16096877.001).
  • [ISSN] 0928-1231
  • [Journal-full-title] Pharmacy world & science : PWS
  • [ISO-abbreviation] Pharm World Sci
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carcinogens; 731DCA35BT / Diethylstilbestrol
  • [Number-of-references] 40
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58. Eiriksson L, Cuartero J, Steed H, Pearcey R, Capstick V, Schepansky A, Faught W, Dundas G: Assessment of outcomes in surgically staged I/II endometrial adenocarcinoma patients treated with postoperative vaginal vault radiotherapy only. Int J Gynecol Cancer; 2010 Nov;20(8):1356-62
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  • [Title] Assessment of outcomes in surgically staged I/II endometrial adenocarcinoma patients treated with postoperative vaginal vault radiotherapy only.
  • OBJECTIVE: To examine the efficacy of vaginal vault radiotherapy as adjuvant treatment for patients with high-grade, stage I/II endometrial adenocarcinoma who have been surgically staged.
  • METHODS: A retrospective chart review of 77 women between 1995 and 2006 with high-grade surgically staged I and II endometrial adenocarcinoma, who were treated with postoperative vaginal vault radiotherapy alone, was performed.
  • There were 10 recurrences (13.0%), of which 3 were local: 1 involving the vaginal apex; 1, the lower vagina and pelvic sidewall; and 1, the lower vagina.
  • CONCLUSIONS: It seems that for this cohort of 77 patients with surgically staged I and II grade 3 endometrial adenocarcinoma, adjuvant vaginal vault radiotherapy alone leads to acceptable recurrence rates and survival while minimizing morbidity.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Endometrial Neoplasms / radiotherapy. Endometrial Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Algorithms. Combined Modality Therapy. Female. Humans. Middle Aged. Neoplasm Staging / methods. Postoperative Care / methods. Prognosis. Radiotherapy, Adjuvant. Radiotherapy, Conformal / methods. Retrospective Studies. Treatment Outcome. Vagina / pathology

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  • (PMID = 21051977.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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59. Hurrell DP, Jamison J, Dobbs SP, McCluggage WG: Cervical adenocarcinoma in situ recurring as vaginal adenocarcinoma 16 years after hysterectomy. Int J Gynecol Pathol; 2009 May;28(3):296-300
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  • [Title] Cervical adenocarcinoma in situ recurring as vaginal adenocarcinoma 16 years after hysterectomy.
  • We report a case in which a vaginal adenocarcinoma was discovered in a 67-year-old woman 16 years after hysterectomy for cervical adenocarcinoma in situ.
  • Both the vaginal and cervical lesions exhibited morphologic and immunohistochemical (CDX2-positive) features of intestinal differentiation.
  • Linear array human papillomavirus genotyping demonstrated the vaginal adenocarcinoma to contain human papillomavirus 45.
  • We believe the vaginal adenocarcinoma to be related to the cervical adenocarcinoma in situ and to represent recurrence of this.
  • [MeSH-major] Adenocarcinoma / pathology. Cervical Intraepithelial Neoplasia / pathology. Neoplasm Recurrence, Local / pathology. Uterine Cervical Neoplasms / pathology. Vaginal Neoplasms / pathology


60. Anjarwalla S, Rollason TP, Rooney N, Hirschowitz L: Atypical mucinous metaplasia and intraepithelial neoplasia of the female genital tract--a case report and review of the literature. Int J Gynecol Cancer; 2007 Sep-Oct;17(5):1147-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The metaplastic epithelium extended from the vagina to the serosal surface of the pelvic organs.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Genital Neoplasms, Female / diagnosis
  • [MeSH-minor] Female. Humans. Metaplasia / diagnosis. Metaplasia / pathology

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  • (PMID = 17433059.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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61. Dasanu CA, Herzog TJ: Clear cell adenocarcinoma of the ovary associated with in utero diethylstilbestrol exposure: case report and clinical overview. Medscape J Med; 2009;11(1):6
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  • [Title] Clear cell adenocarcinoma of the ovary associated with in utero diethylstilbestrol exposure: case report and clinical overview.
  • BACKGROUND: Clear cell adenocarcinoma of the vagina and cervix were previously shown to be tumors occurring in female offspring exposed prenatally to diethylstilbestrol.
  • This report describes the first clinical case of clear cell adenocarcinoma of the ovary linked to early diethylstilbestrol exposure in utero.
  • She underwent surgery and staging that revealed clear cell adenocarcinoma confined to the left ovary.
  • CONCLUSION: Our case is consistent with clear cell adenocarcinoma, probably related to diethylstilbestrol exposure in utero.
  • [MeSH-major] Adenocarcinoma, Clear Cell / chemically induced. Diethylstilbestrol / adverse effects. Ovarian Neoplasms / chemically induced. Prenatal Exposure Delayed Effects / chemically induced

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  • (PMID = 19295927.001).
  • [ISSN] 1934-1997
  • [Journal-full-title] Medscape journal of medicine
  • [ISO-abbreviation] Medscape J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 731DCA35BT / Diethylstilbestrol
  • [Other-IDs] NLM/ PMC2654676
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62. Ditto A, Martinelli F, Carcangiu ML, Hanozet F, Solima E, Barisella M, Cerrotta A, Raspagliesi F: Incidental diagnosis of primary vaginal adenocarcinoma of intestinal type: a case report and review of the literature. Int J Gynecol Pathol; 2007 Oct;26(4):490-3
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  • [Title] Incidental diagnosis of primary vaginal adenocarcinoma of intestinal type: a case report and review of the literature.
  • Primary vaginal adenocarcinoma of intestinal type is a rare malignant gynecologic disease.
  • A 53-year-old woman was admitted to our institution with a diagnosis of endometrial adenocarcinoma.
  • A physical examination revealed a 2-cm polypoid lesion of the vagina.
  • The patient underwent surgery for endometrial cancer and wedge resection of the vaginal lesion.
  • The diagnosis of primary vaginal adenocarcinoma of intestinal type was obtained after standard and immunohistochemical analyses of the specimen.
  • No endometrial cancer was detected in the specimen.
  • Extensive radiological investigations and careful immunohistochemical analysis of the specimen are needed for a correct diagnosis of vaginal adenocarcinoma of intestinal type.
  • [MeSH-major] Adenocarcinoma / pathology. Vaginal Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Endometrial Neoplasms / pathology. Female. Gynecologic Surgical Procedures. Humans. Immunohistochemistry. Incidental Findings. Intestinal Neoplasms / pathology. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Radiotherapy

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  • (PMID = 17885503.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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63. Matthews KS, Numnum TM, Conner MG, Barnes M 3rd: Fertility-sparing radical abdominal trachelectomy for clear cell adenocarcinoma of the upper vagina: a case report. Gynecol Oncol; 2007 Jun;105(3):820-2
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  • [Title] Fertility-sparing radical abdominal trachelectomy for clear cell adenocarcinoma of the upper vagina: a case report.
  • BACKGROUND: Clear cell adenocarcinoma (CCA) of the vagina is traditionally treated with radical surgical resection with tailored postoperative radiation when indicated.
  • CASE: A 22 year old female was diagnosed with clinical stage I vaginal clear cell adenocarcinoma in the left fornix abutting the cervix.
  • CONCLUSION: For patients with CCA of the upper vagina, where removal of the cervix is necessary, a radical trachelectomy with upper vaginectomy should be considered to conserve fertility.
  • [MeSH-major] Adenocarcinoma, Clear Cell / surgery. Fertility. Vaginal Neoplasms / surgery

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  • (PMID = 17399769.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Vasilescu C, Stănciulea O, Popa M, Anghel R, Herlea V, Florescu A: Total laparoscopic radical hysterectomy with pelvic lymphadenectomy for endometrial cancer. Chirurgia (Bucur); 2008 Jan-Feb;103(1):99-102
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  • [Title] Total laparoscopic radical hysterectomy with pelvic lymphadenectomy for endometrial cancer.
  • The surgical treatment of endometrial cancer is still a matter of debate.
  • The aim of the case report was to describe the feasibility of total laparoscopic radical hysterectomy with pelvic lymphadenectomy in a 56-years-old Caucasian woman diagnosed with endometrial cancer.
  • Thereafter, by placing the uterine fundus in median and posterior position, the vesicouterine peritoneal fold was opened by scissors and a bladder dissection from the low uterine segment down to the vagina was performed.
  • Next the rectovaginal space is opened and the utero-sacral ligaments divided; this allows the division of para-vaginal attachments.
  • The vagina is sectioned and the specimen is extracted transvaginally.
  • Then the vaginal stump was sutured by laparoscopy.
  • [MeSH-major] Adenocarcinoma / surgery. Endometrial Neoplasms / surgery. Hysterectomy / methods. Laparoscopy. Lymph Node Excision

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  • (PMID = 18459505.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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65. Driss M, Abid L, Mrad K, Dhouib R, Romdhane KB: Primary vaginal adenocarcinoma of intestinal type arising from an adenoma. J Obstet Gynaecol; 2007 Apr;27(3):332-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary vaginal adenocarcinoma of intestinal type arising from an adenoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Intestinal Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Neoplasm Metastasis

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  • (PMID = 17464837.001).
  • [ISSN] 0144-3615
  • [Journal-full-title] Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • [ISO-abbreviation] J Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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66. Illanes D, Broman J, Meyer B, Kredentser D, McElrath T, Timmins P 3rd: Verrucous carcinoma of the endometrium: case history, pathologic findings, brief review of literature and discussion. Gynecol Oncol; 2006 Aug;102(2):375-7
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  • A defined disease of the oral cavity, larynx, esophagus, skin, vulva, vagina and cervix.
  • But a verrucous carcinoma arising from the endometrium without evidence of cervical malignancy or endometrial adenocarcinoma is extremely rare.
  • CASE: A 67-year-old G2P2 menopausal patient that was referred for consultation 1 year after presenting with vaginal bleeding to her gynecologist who subsequently underwent several endometrial biopsies where the pathological findings were repetitively similar: papillary squamous proliferation, cytologically bland with low mitotic activity but extensive proliferation.
  • CONCLUSION: This is a rare form of endometrial cancer with apparent favorable prognosis that must be considered when squamous cells are identified on endometrial samplings.

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  • (PMID = 16529798.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Maekawa S, Hishima T, Yamada Y, Ichikawa H, Natsui S, Shinohara M: [A case of primary urethral adenocarcinoma accompanied by vaginal wall infiltration in which the CA19-9 level was very high]. Hinyokika Kiyo; 2009 Aug;55(8):513-6
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  • [Title] [A case of primary urethral adenocarcinoma accompanied by vaginal wall infiltration in which the CA19-9 level was very high].
  • Computed tomography confirmed a urethral tumor, and transurethral biopsy confirmed adenocarcinoma.
  • On histology, the tumor had spread to the bladder, urethra, and vagina.
  • Based on the above findings, the patient was diagnosed as having primary urethral adenocarcinoma.
  • A urethral tumor accompanied by vaginal wall infiltration is likely to be mistaken for a primary vaginal tumor.
  • To the best of our knowledge, the present patient is the sixth reported case of primary urethral carcinoma accompanied by vaginal wall infiltration in Japan.
  • [MeSH-major] Adenocarcinoma / pathology. Biomarkers, Tumor / blood. CA-19-9 Antigen / blood. Urethral Neoplasms / pathology. Vagina / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Invasiveness / pathology. Urinary Bladder Neoplasms / secondary. Vaginal Neoplasms / secondary

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  • (PMID = 19764540.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen
  • [Number-of-references] 11
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68. Patel H, Joseph JV, Amodeo A, Kothari K: Laparoscopic salvage total pelvic exenteration: Is it possible post-chemo-radiotherapy? J Minim Access Surg; 2009 Oct;5(4):111-4
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  • Indications for total pelvic exenteration in a male (removal of the bladder, prostate and rectum) and in a woman (removal bladder, uterus, vagina, ovaries and rectum) are rare.
  • We report the first two cases of a salvage laparoscopic total pelvic exenteration in a male for rectal adenocarcinoma invading into the bladder and prostate, post-chemo-radiotherapy and in a woman for squamous cell carcinoma of cervix invading the bladder and rectum post-chemo-radiotherapy.

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  • (PMID = 20407571.001).
  • [ISSN] 1998-3921
  • [Journal-full-title] Journal of minimal access surgery
  • [ISO-abbreviation] J Minim Access Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2843126
  • [Keywords] NOTNLM ; Laparoscopy / malignancy / pelvic exenteration
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69. Castillo PA, Aguilar VC, Wexner S, Davila GW: Uterine retroversion for vaginoperineal reconstruction following resection of distal rectal tumors. Dis Colon Rectum; 2010 Mar;53(3):350-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Vaginal and perineal reconstruction following wide resection of locally invasive rectal cancer can be challenging.
  • We present a technique applicable to nonhysterectomized patients who undergo posterior vaginal wall reconstruction with retroversion of the in situ uterus.
  • METHODS: Four nonhysterectomized patients with recurrent rectal carcinoma and abdominoperineal resection with en bloc resection of the posterior vagina leaving a large defect necessitating reconstruction of the vagina, perineum, or both, have undergone posterior vaginal wall and perineal reconstruction with uterine retroversion into the posterior pelvis and fixation to the perineum.
  • CONCLUSION: Uterine retroversion is a viable option for vaginal and perineal reconstruction.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Perineum / surgery. Reconstructive Surgical Procedures / methods. Rectal Neoplasms / surgery. Uterus / surgery. Vagina / surgery

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  • (PMID = 20173485.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Zorrón R, Soldan M, Filgueiras M, Maggioni LC, Pombo L, Oliveira AL: NOTES: transvaginal for cancer diagnostic staging: preliminary clinical application. Surg Innov; 2008 Sep;15(3):161-5
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  • [Title] NOTES: transvaginal for cancer diagnostic staging: preliminary clinical application.
  • Laparoscopy is now a reliable method for staging gastrointestinal cancer, orienting the therapy, and avoiding unnecessary laparotomy.
  • The first case of clinical diagnostic application of transvaginal NOTES for diagnostic cancer staging is presented.
  • On February 28, 2007, a patient with elective surgical indication for diagnostic cancer staging was submitted to transvaginal NOTES procedure, and intra- and postoperative parameters were documented.
  • In a 50-year-old female patient presenting with ascitis, diffuse abdominal pain, and weight loss for 2 months, diagnosis of peritoneal carcinomatosis was suspected, which was also found when a CT scan was performed.
  • Transvaginal NOTES was used for diagnostic staging of the patient, using a colonoscope introduced into the abdomen through a small incision in the vagina.
  • Operative time was 105 min, vaginal access and closure was obtained in 15 min.
  • Abdominal inventory was reliable, and all 16 biopsies taken were positive for ovarian adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Endoscopy / methods. Endoscopy / trends. Ovarian Neoplasms / diagnosis

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  • (PMID = 18614547.001).
  • [ISSN] 1553-3506
  • [Journal-full-title] Surgical innovation
  • [ISO-abbreviation] Surg Innov
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Martynychen MG, Rabelo LM, Silva RL, Escuissato DL: Carcinomatous lymphangitis as the initial manifestation of ovarian adenocarcinoma. J Bras Pneumol; 2007 Sep-Oct;33(5):609-11
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  • [Title] Carcinomatous lymphangitis as the initial manifestation of ovarian adenocarcinoma.
  • We describe herein the case of a 42-year-old woman in whom the first manifestation of an ovarian adenocarcinoma was carcinomatous lymphangitis of the lung, an unusual presentation of the disease.
  • [MeSH-major] Adenocarcinoma / secondary. Lung Neoplasms / complications. Lymphangitis / complications. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Biopsy. Bronchoscopy. Female. Humans. Tomography, X-Ray Computed. Vagina / ultrasonography

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  • (PMID = 18026661.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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72. Hollowell ML, Goulart RA, Gang DL, Otis CN, Prior J, Sachs BF, Pantanowitz L: Cytologic features of müllerian papilloma of the cervix: mimic of malignancy. Diagn Cytopathol; 2007 Sep;35(9):607-11
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  • Müllerian papilloma is a rare benign tumor of the cervix and/or vagina that occurs predominantly in young children.
  • We report for the first time, to our knowledge, the cytologic findings of a benign müllerian papilloma from the vaginal fluid specimen of a 15-mo-old girl using touch prep, ThinPrep, and cell block preparations.
  • The clinical findings and cytomorphology of a benign müllerian papilloma can mimic those of malignant lesions of the female lower genital tract such as sarcoma botryoides and adenocarcinoma.
  • An awareness of this entity and its potential to mimic these more aggressive neoplasms is essential for accurate diagnosis and to avoid over-treatment.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Diagnosis, Differential. Female. Humans. Infant. Rhabdomyosarcoma, Embryonal / diagnosis. Rhabdomyosarcoma, Embryonal / pathology


73. Lotan TL, Tefs K, Schuster V, Miller J, Manaligod J, Filstead A, Yamada SD, Krausz T: Inherited plasminogen deficiency presenting as ligneous vaginitis: a case report with molecular correlation and review of the literature. Hum Pathol; 2007 Oct;38(10):1569-75
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  • Microscopically, the vagina, cervix, endometrium, ovaries, and parametrial tissues showed innumerable deposits of paucicellular hyaline material with adjacent inflammation.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Adult. Diagnosis, Differential. Female. Humans. Vaginal Neoplasms / pathology

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  • (PMID = 17889676.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9001-91-6 / Plasminogen
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74. Schulte-Baukloh H, Knösel T, Coumbos A, Miller K, Knispel HH: [A look beyond urology: vaginal cancer]. Urologe A; 2006 Dec;45(12):1540-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A look beyond urology: vaginal cancer].
  • Primary carcinomas of the vagina are very rare.
  • Nevertheless, they need to be included in differential diagnoses when carrying out a urological examination of the pelvic floor and the vagina in patients with micturition problems, also in younger patients: we report a case of a 35-year-old woman with a primary carcinoma of the vagina and present a review of the literature.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Urination Disorders / diagnosis. Urination Disorders / prevention & control. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / therapy

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  • [Cites] Gynecol Oncol. 2002 Feb;84(2):263-70 [11812085.001]
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  • (PMID = 16902789.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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75. Yücesoy AN, Ercan Bülbül E, Bahat R, Cafer Köşkeroğlu C: Transvaginal low anterior resection for rectal cancer. Tech Coloproctol; 2008 Mar;12(1):83-5; discussion 85-6
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  • [Title] Transvaginal low anterior resection for rectal cancer.
  • Adenocarcinoma of the lower rectum can be resected with a sphincter-sparing procedure but exposure of the lower pelvis may be difficult and sphincter function may be compromised.
  • We have performed a low anterior resection for rectal cancer in a 69-year-old woman with mobilisation of the tumour and anastomosis performed transvaginally without a covering stoma.
  • Transvaginal low anterior resection is an alternative route which may be useful in cases of difficult exposure of low rectal cancer.
  • [MeSH-major] Adenocarcinoma / surgery. Digestive System Surgical Procedures / methods. Rectal Neoplasms / surgery. Vagina

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  • [Cites] Ann Surg. 1996 Nov;224(5):603-8 [8916875.001]
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  • (PMID = 18512019.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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76. Martínez-Monge R, Nagore G, Cambeiro M, Garrán C, Villafranca E, Jurado M: Intravaginal 1-week high-dose-rate brachytherapy alone for Stages I-II endometrial cancer. Brachytherapy; 2007 Jul-Sep;6(3):195-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravaginal 1-week high-dose-rate brachytherapy alone for Stages I-II endometrial cancer.
  • METHODS AND MATERIALS: From December 1999 to February 2005, 50 patients with International federation of gynecology and obstetrics Stages IA-IIB endometrioid endometrial adenocarcinoma were treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy followed by postoperative HDR brachytherapy alone.
  • No vaginal or pelvic recurrences have been observed.
  • CONCLUSIONS: The results reported in this study are in agreement with previous reports of postoperative HDR brachytherapy alone in early-stage endometrial cancer.
  • [MeSH-major] Adenocarcinoma, Clear Cell / radiotherapy. Brachytherapy / methods. Carcinoma, Adenosquamous / radiotherapy. Endometrial Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Dose-Response Relationship, Drug. Feasibility Studies. Female. Follow-Up Studies. Humans. Hysterectomy. Middle Aged. Neoplasm Staging / methods. Ovariectomy / methods. Postoperative Care / methods. Radiotherapy, Adjuvant / methods. Retrospective Studies. Treatment Outcome. Vagina

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  • (PMID = 17681240.001).
  • [ISSN] 1538-4721
  • [Journal-full-title] Brachytherapy
  • [ISO-abbreviation] Brachytherapy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Liu W, Dubinett S, Patterson SL, Kelly KA: COX-2 inhibition affects growth rate of Chlamydia muridarum within epithelial cells. Microbes Infect; 2006 Feb;8(2):478-86
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  • To prove this, the human lung adenocarcinoma cell line A549 was then infected with different MOIs of C. muridarum in the presence of multiple concentrations of NS-398 in vitro.

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  • (PMID = 16297651.001).
  • [ISSN] 1286-4579
  • [Journal-full-title] Microbes and infection
  • [ISO-abbreviation] Microbes Infect.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI026328; United States / NIAID NIH HHS / AI / R01-AI26328
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] France
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
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78. Tjalma WA, Colpaert CG: Primary vaginal adenocarcinoma of intestinal type arising from a tubulovillous adenoma. Int J Gynecol Cancer; 2006 May-Jun;16(3):1461-5
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  • [Title] Primary vaginal adenocarcinoma of intestinal type arising from a tubulovillous adenoma.
  • Enteric or intestinal-type neoplasms of the vagina are extremely rare.
  • On clinical examination, a lesion on the posterior vaginal wall was noticed.
  • Biopsy revealed an adenocarcinoma of the intestinal type, with a small remnant of a villous adenoma.
  • This led to the conclusion that the lesion was a primary intestinal-type adenocarcinoma of the vagina that had arisen from a vaginal villous adenoma.
  • It is important to be aware of this tumor type and to distinguish them from metastatic colorectal adenocarcinoma in order to plan appropriate treatment.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Intestinal Neoplasms / diagnosis. Middle Aged

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  • (PMID = 16803550.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. van Dijck JA, Doorduijn Y, Bulten JH, Verloop J, Massuger LF, Kiemeney BA: [Vaginal and cervical cancer due to diethylstilbestrol (DES); end epidemic]. Ned Tijdschr Geneeskd; 2009;153:A366
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  • [Title] [Vaginal and cervical cancer due to diethylstilbestrol (DES); end epidemic].
  • [Transliterated title] Vagina- en cervixcarcinoom door diëthylstilbestrol (des). Einde epidemie.
  • OBJECTIVE: To determine the current situation regarding the epidemic of clear cell adenocarcinoma of the vagina and the uterine cervix (CCAC) in relation to the exposure in utero to diethylstilbestrol (DES).
  • METHODS: Patients with CCAC of the uterine cervix or vagina born after 1946 and diagnosed in the period 1969-2005, were identified through the Nationwide network and registry of histo- and cytopathology in the Netherlands and from 2003 onwards through the Netherlands Cancer Registry.
  • For the patients who did not provide consent, only the date of diagnosis and age at diagnosis were known (n = 10).
  • Age at diagnosis varied from 8-54 years (mean: 28 years).
  • The mean age at diagnosis was 24 years for exposed patients compared to 32 years for non-exposed patients.
  • CONCLUSION: Since 2000, the incidence of CCAC of the vagina and cervix has decreased markedly compared to the situation in the 1980s and 1990 s.
  • [MeSH-major] Adenocarcinoma, Clear Cell / epidemiology. Diethylstilbestrol / adverse effects. Uterine Cervical Neoplasms / epidemiology. Vaginal Neoplasms / epidemiology


80. Ludwin I, Ludwin A, Basta A: [Influence of vaginal microflora on the presence of persistent atypical squamous cells and atypical glandular cells in pap smear--a 3-year study]. Ginekol Pol; 2010 May;81(5):364-9
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  • [Title] [Influence of vaginal microflora on the presence of persistent atypical squamous cells and atypical glandular cells in pap smear--a 3-year study].
  • AIM OF THE STUDY: the evaluation of influence of abnormal vaginal biocoenosis on presence and maintenance ASC and AGC in Pap smears.
  • In all women the vaginal flora was assessed by Nugent scale.
  • RESULTS: Vaginal flora was normal in 157 (75.8%) and pathological in 50 (24.1%) women with ASC.
  • In the ASC subgroup, the highest proportion of physiological vaginal flora was observed in 151 patients (77.4%) with ASC-US, in comparison to 44 (22.6%) with ASC-H, in which the percentage of women with normal or abnormal flora was the same (50% vs 50%).
  • In case of AGC, vaginal culture was physiological in 23 (65.7%) women, and in 12 (34.3%) abnormal vaginal flora with features of the inflammation.
  • The statistically significant influence of abnormal vaginal flora on the presence of atypical endometrial and endocervical cells was not observed.
  • CONCLUSIONS: We did not observed any influence of abnormal vaginal flora on the presence, regression and progression of ASC and AGC.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Cervical Intraepithelial Neoplasia / pathology. Cervix Uteri / pathology. Papanicolaou Test. Vagina / microbiology. Vaginal Smears


81. Keese M, Back W, Dinter D, Gladisch R, Joos A, Palma P: Case report: late perianal mucinous adenocarcinoma after Crohn's disease proctectomy: an oncological rarity. World J Surg Oncol; 2005 Jun 29;3:42
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  • [Title] Case report: late perianal mucinous adenocarcinoma after Crohn's disease proctectomy: an oncological rarity.
  • While carcinoma formation originating from ano-rectal fistulas is generally considered as a rare event there are different publications reporting on mucinous adenocarcinoma formation in association with a neovagina and rectovaginal fistulas.
  • To the best of our knowledge this is the first description of a perianal mucinous adenocarcinoma arising in a patient after Crohn's disease proctocolectomy.
  • CASE PRESENTATION: We report the case of a 50-year old female with a mucinous adenocarcinoma forming in the perineum eleven years after proctocolectomy for Crohn's disease.
  • Histological examination revealed a mucinous adenocarcinoma.
  • Exenteration including vagina, uterus and ovaries together with the coccygeal-bone was performed.
  • CONCLUSION: Mucinous adenocarcinoma formation is a rare complication of Crohn's disease and so far unreported after proctocolectomy.

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  • (PMID = 15987512.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1190221
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82. Sauder K, Wilbur DC, Duska L, Tambouret RH: An approach to post-radical trachelectomy vaginal-isthmus cytology. Diagn Cytopathol; 2009 Jun;37(6):437-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An approach to post-radical trachelectomy vaginal-isthmus cytology.
  • Radical trachelectomy (RT) is the surgical amputation of the uterine cervix with paracervical lymphadenectomy, performed in reproductive age women to treat invasive squamous-cell carcinoma or endocervical adenocarcinoma while preserving the uterine corpus for potential child bearing.
  • Post-RT patient monitoring includes isthmic-vaginal cytology.
  • Fifty-four post-RT vaginal-isthmic cytology specimens were reviewed from nine patients, seven with adenocarcinoma, and two with squamous-cell carcinoma.
  • In particular, a primary diagnosis of adenocarcinoma makes differentiating benign reactive glandular cells from recurrence a critical issue.
  • [MeSH-major] Cervix Uteri / surgery. Cytological Techniques / methods. Vagina / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19217064.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Gangopadhyay M, Raha K, Sinha SK, De A, Bera P, Pati S: Endodermal sinus tumor of the vagina in children: a report of two cases. Indian J Pathol Microbiol; 2009 Jul-Sep;52(3):403-4
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  • [Title] Endodermal sinus tumor of the vagina in children: a report of two cases.
  • Malignant tumors of the vagina in infants and children are rare, with primary germ cell tumor (endodermal sinus tumor [EST]) being rarer, which carries a dismal prognosis.
  • This tumor is often clinically mistaken as botryoid rhabdomyosarcoma and, on histopathological examination, is often misdiagnosed as clear cell adenocarcinoma.
  • Two cases of EST of the vagina in infants aged 9 and 17 months are reported.
  • Both the patients presented with bleeding per vagina and clinically and by ultrasonography were diagnosed as sarcoma botryoides.
  • [MeSH-major] Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / pathology. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / pathology
  • [MeSH-minor] Fatal Outcome. Female. Hemorrhage / etiology. Histocytochemistry. Humans. Infant. Treatment Outcome. Vagina / pathology. alpha-Fetoproteins / analysis

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  • (PMID = 19679975.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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84. Fleisch MC, Hatch KD: Laparoscopic assisted parametrectomy/upper vaginectomy (LPUV)-technique, applications and results. Gynecol Oncol; 2005 Sep;98(3):420-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: In this analysis, we summarize our experiences with the laparoscopic parametrectomy/upper vaginectomy (LPUV) as a treatment option for patients with an unexpected finding of cervical cancer after simple hysterectomy as well as for patients with cancer of the vaginal cuff.
  • METHODS: From 1995-2004, 6 of our patients underwent LPUV including 5 patients with stage Ib(1) cervical cancer and one patient with Ia(1) cervical cancer.
  • Retrospective FIGO staging revealed stage Ib(1) (n = 5) and stage Ia(1) (n = 1) cervical cancer.
  • Histopathological evaluation found residual adenocarcinoma in situ in one patient and no malignancy in all other specimen.
  • CONCLUSION: LPUV is an alternative to open parametrectomy or radiation therapy in patients with unexpected cervical cancer after simple hysterectomy or cancer of the vaginal stump.
  • [MeSH-major] Hysterectomy, Vaginal / methods. Uterine Cervical Neoplasms / surgery. Vagina / surgery
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Female. Humans. Laparoscopy / methods. Middle Aged. Neoplasm Staging. Retrospective Studies


85. Miller DA, Richardson S, Grigsby PW: A new method of anatomically conformal vaginal cuff HDR brachytherapy. Gynecol Oncol; 2010 Mar;116(3):413-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A new method of anatomically conformal vaginal cuff HDR brachytherapy.
  • OBJECTIVE: HDR brachytherapy to the vaginal cuff using rigid intracavitary cylinders has a limited capacity to adapt to patient-specific anatomy.
  • This study describes the use and dosimetry of a new method of anatomically conformal post-operative vaginal cuff HDR brachytherapy using an intra-vaginal balloon applicator.
  • METHODS: Thirty consecutive patients with endometrial carcinoma underwent a hysterectomy and received adjuvant HDR brachytherapy in 6 weekly fractions using an intra-vaginal balloon.
  • Optimal distension of the balloon to conform to the vaginal cuff was clinically determined to achieve complete balloon surface apposition with the vaginal mucosa and was confirmed radiographically.
  • Radiation dose was prescribed to the vaginal mucosa and brachytherapy CT simulation was performed to optimize the irradiation dose in 3-D.
  • The mean dose from brachytherapy to the 2 cc volume of the bladder and rectum was 48.6% and 71.1% of the prescribed vaginal mucosal dose, respectively.
  • 100% of the prescribed dose covered an average of 95.6% of the vaginal cuff.
  • There were no acute complications or vaginal cuff recurrences at a mean follow-up of 13 months.
  • CONCLUSIONS: Post-operative vaginal cuff HDR brachytherapy using an intra-vaginal balloon applicator which conforms to the individual patient's vaginal cuff provides excellent radiation dose coverage of the vaginal mucosa with acceptable doses to the bladder and rectum.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Adult. Aged. Aged, 80 and over. Carcinoma, Endometrioid / pathology. Carcinoma, Endometrioid / radiotherapy. Catheterization / methods. Female. Humans. Middle Aged. Neoplasm Staging. Radiation Injuries / etiology. Rectum / radiation effects. Urinary Bladder / radiation effects. Vagina / anatomy & histology

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  • (PMID = 19892389.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Paczos TA, Ackers S, Odunsi K, Lele S, Mhawech-Fauceglia P: Primary vaginal adenocarcinoma arising in vaginal adenosis after CO2 laser vaporization and 5-fluorouracil therapy. Int J Gynecol Pathol; 2010 Mar;29(2):193-6
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  • [Title] Primary vaginal adenocarcinoma arising in vaginal adenosis after CO2 laser vaporization and 5-fluorouracil therapy.
  • Subsequent vaginal smears revealed high-grade vaginal intraepithelial neoplasia (VAIN III) on Pap smear with positive human papilloma virus (HPV) testing.
  • Over the course of 2 years, the patient underwent 2 CO(2) laser vaporization procedures of the upper vagina and intermittent 5-fluorouracil therapy.
  • A biopsy performed at the time of the second laser procedure revealed endocervical-type well-differentiated adenocarcinoma, associated with VAIN III.
  • The vaginectomy specimen showed residual adenocarcinoma associated with VAIN-III and extensive vaginal adenosis with free resection margins.
  • This is the second reported case in the literature of adenocarcinoma arising in vaginal adenosis after 5-fluorouracil.
  • Herein, we highlight these important findings and shed some light on the pathogenesis of vaginal adenosis and the subsequent development of vaginal adenocarcinoma.

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  • (PMID = 20173507.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / T32 CA108456
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; U3P01618RT / Fluorouracil
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87. Benhidjeb T, Stark M: An innovative technique for colorectal specimen retrieval: a new era of "Natural Orifice Specimen Extraction" (N.O.S.E.). Dis Colon Rectum; 2010 Apr;53(4):502-3; author reply 503
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / surgery. Adenomatous Polyposis Coli / surgery. Proctocolectomy, Restorative / methods. Rectal Neoplasms / surgery. Vagina / surgery

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  • [CommentOn] Dis Colon Rectum. 2008 Jul;51(7):1120-4 [18481149.001]
  • (PMID = 20305453.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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88. Langmár Z, Harsányi L, Székely E, Járay B, Csömör S, Kazy Z: [Primary adenocarcinoma of the rectovaginal septum without associated endometriosis]. Orv Hetil; 2008 Nov 23;149(47):2251-3
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  • [Title] [Primary adenocarcinoma of the rectovaginal septum without associated endometriosis].
  • Primary adenocarcinoma of the rectovaginal septum is a rare clinical entity that arises in most of the cases from endometriosis.
  • The authors report a successfully treated case of primary adenocarcinoma of the rectovaginal septum without associated endometriosis in a 68-year-old woman.
  • Diagnostic and treatment modalities were reviewed by the authors emphasizing that the early diagnosis is difficult and the only curative method is primary surgical therapy.
  • [MeSH-major] Carcinoma, Endometrioid. Genital Neoplasms, Female. Rectal Neoplasms. Vagina
  • [MeSH-minor] Aged. Early Diagnosis. Female. Humans. Ovarian Neoplasms / secondary

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  • (PMID = 19004748.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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89. Frank SJ, Deavers MT, Jhingran A, Bodurka DC, Eifel PJ: Primary adenocarcinoma of the vagina not associated with diethylstilbestrol (DES) exposure. Gynecol Oncol; 2007 May;105(2):470-4
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  • [Title] Primary adenocarcinoma of the vagina not associated with diethylstilbestrol (DES) exposure.
  • OBJECTIVE: Primary non-diethylstilbestrol (DES)-associated adenocarcinoma of the vagina (NDAV) is a rare entity that has not been well described.
  • Survival rates were calculated and outcomes of patients with NDAV were compared with those of patients with squamous cell carcinoma (SCC) of the vagina treated similarly over the same period.
  • [MeSH-major] Adenocarcinoma / etiology. Adenocarcinoma / pathology. Diethylstilbestrol / adverse effects. Vaginal Neoplasms / etiology. Vaginal Neoplasms / pathology

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  • (PMID = 17292459.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 731DCA35BT / Diethylstilbestrol
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90. Verloop J, van Leeuwen FE, Helmerhorst TJ, van Boven HH, Rookus MA: Cancer risk in DES daughters. Cancer Causes Control; 2010 Jul;21(7):999-1007
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  • [Title] Cancer risk in DES daughters.
  • OBJECTIVE: We examined long-term risk of cancer in women exposed to diethylstilbestrol (DES) in utero.
  • Cancer incidence was assessed through linkage with the Dutch pathology database (PALGA) and the Netherlands Cancer Registry and compared with the Dutch female population.
  • No overall increased risk of cancer was found (standardized incidence ratio [SIR] = 1.01; 95% confidence interval [CI] = 0.91, 1.13).
  • The risk of clear cell adenocarcinoma of the vagina and cervix (CCA) was statistically significantly increased (SIR = 24.23; 95% CI = 8.89, 52.74); the elevated risk persisted above 40 years of age.
  • No excess risks were found for other sites, including breast cancer.
  • CONCLUSIONS: Except for an elevated risk of CCA, persisting at older ages, and an increased risk of melanoma at young ages, we found no increased risk of cancer.
  • Longer follow-up is warranted to examine cancer risk at ages when cancer occurs more frequently.
  • [MeSH-major] Adenocarcinoma, Clear Cell / epidemiology. Diethylstilbestrol / adverse effects. Nuclear Family. Vaginal Neoplasms / epidemiology

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  • (PMID = 20204493.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Estrogens, Non-Steroidal; 731DCA35BT / Diethylstilbestrol
  • [Other-IDs] NLM/ PMC2883094
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91. Jahnke A, Domke R, Makovitzky J, Nizze H, Briese V: Vaginal metastasis of lung cancer: a case report. Anticancer Res; 2005 May-Jun;25(3A):1645-8
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  • [Title] Vaginal metastasis of lung cancer: a case report.
  • BACKGROUND: Lung cancer is the second most common malignant tumor, with increasing incidence in the female population.
  • Metastases in the vagina of primary lung cancer have not been previously reported.
  • CASE REPORT: Lung cancer was diagnosed in a 67-year-old, postmenopausal woman.
  • Histological and immunohistochemical examinations of a vaginal excisional biopsy revealed metastatic adenocarcinoma, with the staining reactivity as primary lung neoplasm.
  • CONCLUSION: Some cases of vaginal metastases from extragenital tumors have been previously reported.
  • This is the first report of vaginal metastases from primary lung cancer.
  • We suggest that adenocarcinoma especially tend to form metastases in the female genital tract.
  • The present case emphasizes that, in women with unclear symptoms and findings in the small pelvis (e.g. urination problems, suspect vaginal tumor), the formation of such metastases should be taken into account.
  • [MeSH-major] Lung Neoplasms / pathology. Vaginal Neoplasms / secondary


92. Erşahin C, Huang M, Potkul RK, Hammadeh R, Salhadar A: Mesonephric adenocarcinoma of the vagina with a 3-year follow-up. Gynecol Oncol; 2005 Dec;99(3):757-60
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  • [Title] Mesonephric adenocarcinoma of the vagina with a 3-year follow-up.
  • BACKGROUND: Mesonephric adenocarcinoma of the vagina is exceedingly rare, with only one well-documented case in the literature.
  • Little is known regarding clinical presentation, pathological characteristics, therapy, or prognosis of the vaginal mesonephric adenocarcinoma.
  • CASE: A 55-year-old woman presented with a polypoid mass at the right vaginal apex, extending to the right paravaginal tissue.
  • The tumor was an adenocarcinoma with ductal and tubular pattern arising in a background of mesonephric remnants.
  • CONCLUSION: We report the second case of mesonephric adenocarcinoma of the vagina with metastasis to the right fallopian tube and to one paravaginal lymph node.
  • [MeSH-major] Adenocarcinoma / pathology. Mesonephroma / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 16137744.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Sinna R, Benhaim T, Qassemyar Q, Bréhant O, Mauvais F: Double L-shaped free-style perforator flap for perineal and vaginal reconstruction after cylindrical abdominoperineal resection. J Plast Reconstr Aesthet Surg; 2010 Oct;63(10):1740-3
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  • [Title] Double L-shaped free-style perforator flap for perineal and vaginal reconstruction after cylindrical abdominoperineal resection.
  • We present an original double L-shaped free-style propeller flap used to reconstruct the vagina and the perineum of a 57-year-old patient after the resection of a T4 tumour of the lower rectum.
  • [MeSH-major] Adenocarcinoma / surgery. Perineum / surgery. Reconstructive Surgical Procedures / methods. Rectal Neoplasms / surgery. Surgical Flaps / blood supply. Vagina / surgery

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  • [Copyright] Copyright 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20347625.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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94. Amanie J, Pearcey RG, Honore L, Sloboda R: Metastatic adenocarcinoma of the cervix in a delivery-induced traumatic lower vaginal tear. Gynecol Oncol; 2005 Mar;96(3):857-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adenocarcinoma of the cervix in a delivery-induced traumatic lower vaginal tear.
  • BACKGROUND: Noncontiguous vaginal metastasis is rare in cervical cancer and is usually reported in the context of traumatic implantation.
  • Traumatic vaginal implantation of cervical carcinoma has been documented in episiotomy, port site, or incision scars.
  • CASE: We report the only case in the literature with vaginal metastasis associated with traumatic vaginal tear presenting with concomitant metastasis and the second case in the literature with a concomitant vaginal metastasis.
  • [MeSH-major] Adenocarcinoma / secondary. Uterine Cervical Neoplasms / pathology. Vagina / injuries. Vaginal Neoplasms / secondary


95. Staiano JJ, Wong L, Butler J, Searle AE, Barton DP, Harris PA: Flap reconstruction following gynaecological tumour resection for advanced and recurrent disease--a 12 year experience. J Plast Reconstr Aesthet Surg; 2009 Mar;62(3):346-51
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  • The predominant site of the primary tumour was vulva, accounting for 83% of the cases, with cervix, ovary, vagina and endometrium making up the remainder.
  • Squamous cell carcinoma was the most common histological type, accounting for 71% of cases, with adenocarcinoma, Paget disease, leiomyosarcoma, melanoma and basosquamous carcinoma making up the remainder.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Genital Neoplasms, Female / surgery. Gynecologic Surgical Procedures / methods. Surgical Flaps / blood supply

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  • (PMID = 18784004.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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96. Sinha B, Stehman F, Schilder J, Clark L, Cardenes H: Indiana University experience in the management of vaginal cancer. Int J Gynecol Cancer; 2009 May;19(4):686-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Indiana University experience in the management of vaginal cancer.
  • PURPOSE: To review our institutional experience in the treatment of primary vaginal cancer and identify predictors for outcome, in particular, recurrence rate.
  • MATERIALS AND METHODS: We retrospectively reviewed the charts of 45 patients identified as having primary squamous cell cancer and adenocarcinoma of the vagina and recorded information regarding both patient and tumor characteristics and treatment modalities.
  • CONCLUSIONS: Early-stage vaginal cancer can be successfully managed with radiation therapy with excellent rates of local control and survival.
  • [MeSH-major] Adenocarcinoma / therapy. Carcinoma, Squamous Cell / therapy. Vaginal Neoplasms / therapy

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  • (PMID = 19509572.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Dubé V, Lickrish GM, MacNeill KN, Colgan TJ: Villoglandular adenocarcinoma in situ of intestinal type of the hymen: de novo origin from squamous mucosa? J Low Genit Tract Dis; 2006 Jul;10(3):156-60
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  • [Title] Villoglandular adenocarcinoma in situ of intestinal type of the hymen: de novo origin from squamous mucosa?
  • Villoglandular adenocarcinoma of intestinal type is a very uncommon neoplasm of unknown origin with only few cases described on the vulva and in the vagina.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma in Situ / diagnosis. Hymen / pathology. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Epithelium / pathology. Female. Humans. Middle Aged. Vaginal Discharge / etiology

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  • (PMID = 16829755.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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98. Schouten van der Velden AP, de Hingh IH, Schijf CP, Bonenkamp HJ, Wobbes T: Metachronous colorectal malignancies: "don't forget the neo vagina". A case report. Gynecol Oncol; 2005 Apr;97(1):279-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metachronous colorectal malignancies: "don't forget the neo vagina". A case report.
  • CASE: A patient with an adenocarcinoma arising from a neovagina constructed with use of a sigmoid segment.
  • [MeSH-major] Adenocarcinoma / pathology. Colon, Sigmoid / surgery. Neoplasms, Second Primary / pathology. Reconstructive Surgical Procedures. Vagina / surgery. Vaginal Neoplasms / pathology

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  • (PMID = 15790477.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Bifulco G, Mandato VD, Mignogna C, Giampaolino P, Di Spiezio Sardo A, De Cecio R, De Rosa G, Piccoli R, Radice L, Nappi C: A case of mesonephric adenocarcinoma of the vagina with a 1-year follow-up. Int J Gynecol Cancer; 2008 Sep-Oct;18(5):1127-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of mesonephric adenocarcinoma of the vagina with a 1-year follow-up.
  • Mesonephric adenocarcinoma deriving from remnants of vaginal mesonephric ducts is one of the rarest tumors of the female genital tract with only three cases reported till date in international literature.
  • Differential diagnosis from other aggressive tumors is complex and controversies exist in the literature regarding the biological behavior, prognosis, and optimal management strategies of these tumors.
  • A well-capsulated mesonephric adenocarcinoma in a background of vaginal mesonephric remnants was diagnosed.
  • In spite of the aggressive biological behavior attributed in literature to mesonephric carcinomas, which is probably due to the complex differential diagnosis with other müllerian tumors, the favorable course of our patient further supports the hypothesis that malignant mesonephric carcinomas may not behave aggressively and that radical surgery alone may be curative.
  • [MeSH-major] Adenocarcinoma / pathology. Mesonephroma / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 18028380.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Batashki I, Amaliev I, Markova D, Amaliev G, Milchev N: [Ovarian cancer with metastatic lesion in the vagina (foetus papiraceus)]. Akush Ginekol (Sofiia); 2009;48(3):49-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ovarian cancer with metastatic lesion in the vagina (foetus papiraceus)].
  • Ovarian cancer spreads primarily by intraperitoneal implantation of exfoliated cancer cells, by lymphatic dissemination, and by haematogenous spread.
  • Very rarely it metastasizes to cervix, vulva and vagina; this type of metastases present a diagnostic challenge to the gynecologist and pathologist.
  • We present a case of ovarian cancer with initial clinical manifestation-lesion of the vagina.
  • [MeSH-major] Adenocarcinoma / pathology. Ovarian Neoplasms / pathology. Vagina / pathology. Vaginal Neoplasms / secondary






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