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1. Wu TJ, Yeh CN, Chao TC, Jan YY, Chen MF: Prognostic factors of primary small bowel adenocarcinoma: univariate and multivariate analysis. World J Surg; 2006 Mar;30(3):391-8; discussion 399
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors of primary small bowel adenocarcinoma: univariate and multivariate analysis.
  • BACKGROUND: Adenocarcinoma of the small bowel is relatively less common than malignancies of the esophagus, stomach, and colorectum.
  • In small bowel adenocarcinoma, various prognostic factors influence the disease-free status and overall survival rates.
  • MATERIALS AND METHODS: Eighty patients who were diagnosed with small bowel adenocarcinoma and treated at our institute between 1983 and 2003 were retrospectively reviewed.
  • CONCLUSIONS: Poor prognosis of small bowel adenocarcinoma may be related to a delay in the diagnosis and treatment of the disease.
  • Curative resection is the aim of surgical treatment for small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small

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  • (PMID = 16479330.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Popnikolov NK, Gatalica Z, Adegboyega PA, Norris BA, Pasricha PJ: Downregulation of TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L in Barrett's esophagus with dysplasia and adenocarcinoma. Appl Immunohistochem Mol Morphol; 2006 Jun;14(2):161-5
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  • [Title] Downregulation of TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L in Barrett's esophagus with dysplasia and adenocarcinoma.
  • The aim of this study was to compare TRAIL/Apo2L expression in normal gastroesophageal (GE) junction, Barrett's esophagus with and without dysplasia, and associated adenocarcinoma.
  • Immunohistochemical evaluation of TRAIL expression was performed on formalin-fixed paraffin-embedded sections from 29 GE junction/esophageal biopsies, 20 gastric biopsies, 6 esophagectomies, 2 small bowel resection specimens, and 5 colon biopsies.
  • TRAIL was expressed in the foveolar epithelium of the histologically normal GE junctional mucosa and stomach as well as in the normal intestinal epithelium, with maximal expression in the surface epithelium.
  • TRAIL was rarely and weakly (1+) expressed in Barrett's esophagus with dysplasia (3/18, 16.7%) and adenocarcinoma (1/10, 10.0%) (P<0.001).
  • Similarities in the topographic pattern of TRAIL expression in the normal GE junction, stomach, small intestine, and colon suggest a common function of TRAIL throughout the gastrointestinal tract.

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  • (PMID = 16785783.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TNF-Related Apoptosis-Inducing Ligand
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3. Chong AK, Chin BW, Meredith CG: Clinically significant small-bowel pathology identified by double-balloon enteroscopy but missed by capsule endoscopy. Gastrointest Endosc; 2006 Sep;64(3):445-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinically significant small-bowel pathology identified by double-balloon enteroscopy but missed by capsule endoscopy.
  • BACKGROUND: Capsule endoscopy (CE) is increasingly being used to investigate the small bowel for various indications, including obscure GI bleeding (OGB).
  • Double-balloon enteroscopy (DBE) is a new endoscopic technique developed to potentially view the entire small intestine while allowing therapeutic options to be carried out when appropriate.
  • OBJECTIVE: We described 4 patients with small-bowel pathology missed on CE but detected by DBE.
  • INTERVENTIONS: DBE followed by surgical exploration and resection of small-bowel pathology.
  • Definitive treatment of small-bowel pathology by surgical resection.
  • RESULTS: CE did not identify the small-bowel pathology in all 4 patients.
  • The 3 patients with OGB had small-bowel masses found by DBE.
  • Two of these were GI stromal tumors and one was an adenocarcinoma.
  • LIMITATIONS: Retrospective study and small sample size.
  • If there is a high index of suspicion of small-bowel pathology despite a negative CE, DBE should be performed.
  • [MeSH-major] Endoscopy, Gastrointestinal / methods. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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  • (PMID = 16923502.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Gonda TA, Khan SU, Cheng J, Lewis SK, Rubin M, Green PH: Association of intussusception and celiac disease in adults. Dig Dis Sci; 2010 Oct;55(10):2899-903
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two patients were found to have lead-point intussusceptions and both had small-bowel adenocarcinoma, and 10/14 had severe villous atrophy (subtotal or total).
  • Among those with established celiac disease, IS was detected early, within 3 years of diagnosis.
  • Adenocarcinoma needs to be excluded.
  • [MeSH-minor] Abdominal Pain / epidemiology. Abdominal Pain / pathology. Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adult. Atrophy. Biopsy. Capsule Endoscopy. Chi-Square Distribution. Databases, Factual. Female. Follow-Up Studies. Humans. Incidental Findings. Intestinal Neoplasms / epidemiology. Intestinal Neoplasms / pathology. Male. Middle Aged

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  • (PMID = 20033844.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Zaanan A, Afchain P, Carrere N, Aparicio T: [Small bowel adenocarcinoma]. Gastroenterol Clin Biol; 2010 Aug-Sep;34(6-7):371-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Small bowel adenocarcinoma].
  • [Transliterated title] Adénocarcinome de l'intestin grêle.
  • Small bowel adenocarcinoma is a rare tumor.
  • Diagnosis is usually performed at an advanced stage because of non-specific nature of clinical manifestations.
  • New methods of radiological and endoscopic exploration of small intestine should allow earlier diagnosis.
  • A national prospective cohort study is currently evaluating the results of chemotherapy (recommended protocol: FOLFOX) as adjuvant and palliative treatment of small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Adenocarcinoma / therapy. Intestinal Neoplasms / etiology. Intestinal Neoplasms / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Genetic Predisposition to Disease. Humans. Intestine, Small / pathology. Intestine, Small / surgery. Lymphatic Metastasis. Neoplasm Metastasis. Prognosis. Risk Factors

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20537487.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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6. Manfredi S, Thiebot T, Henno S, Falize L, Bretagne JF, Meunier B: Complete response of an initially non-surgical adenocarcinoma of the duodenum to chemotherapy with the FOLFOX 4 regimen. J Gastrointest Surg; 2009 Dec;13(12):2309-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complete response of an initially non-surgical adenocarcinoma of the duodenum to chemotherapy with the FOLFOX 4 regimen.
  • INTRODUCTION: The incidence of adenocarcinoma of the small bowel is very low in comparison with that of colorectal cancer.
  • No standard chemotherapy is defined for non-surgical adenocarcinoma of the small bowel.
  • CASE REPORT: We report here the case of a young patient with an initially non-surgical adenocarcinoma of the duodenum treated in a palliative setting with the FOLFOX 4 chemotherapy regimen.
  • CONCLUSION: The FOLFOX 4 regimen seems to be efficacious for some small-bowel adenocarcinomas and can be expected to lead to downstaging.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy

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  • (PMID = 19585173.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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7. Saindane AM, Losada M, Macari M: Focal amyloidoma of the small bowel mimicking adenocarcinoma on CT. AJR Am J Roentgenol; 2005 Nov;185(5):1187-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Focal amyloidoma of the small bowel mimicking adenocarcinoma on CT.
  • [MeSH-major] Amyloidosis / radiography. Intestinal Diseases / radiography. Intestine, Small. Tomography, X-Ray Computed
  • [MeSH-minor] Adenocarcinoma / radiography. Aged. Contrast Media. Diagnosis, Differential. Humans. Intestinal Neoplasms / radiography. Male

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  • (PMID = 16247131.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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8. Bailey AA, Debinski HS, Appleyard MN, Remedios ML, Hooper JE, Walsh AJ, Selby WS: Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center Australian experience. Am J Gastroenterol; 2006 Oct;101(10):2237-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center Australian experience.
  • OBJECTIVE: The objective of the study was to examine diagnosis and outcome in a series of patients with small bowel tumors detected by capsule endoscopy (CE) in three Australian centers.
  • Seventeen tumors were malignant: five adenocarcinomas, six carcinoids, two melanoma metastases, two gastrointestinal stromal tumors (GIST), one colon carcinoma metastasis, one non-Hodgkin's lymphoma.
  • Of the five patients with primary adenocarcinoma only one remains disease free.
  • CONCLUSIONS: Small bowel tumors are a significant finding at CE and are often missed by other methods of investigation.
  • [MeSH-major] Capsule Endoscopy. Intestinal Neoplasms / pathology. Intestinal Neoplasms / therapy. Intestine, Small

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  • (PMID = 17032187.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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9. Monte MJ, Ballestero MR, Briz O, Perez MJ, Marin JJ: Proapoptotic effect on normal and tumor intestinal cells of cytostatic drugs with enterohepatic organotropism. J Pharmacol Exp Ther; 2005 Oct;315(1):24-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Proapoptotic effect on normal and tumor intestinal cells of cytostatic drugs with enterohepatic organotropism.
  • The proapoptotic effect of cisplatin bile acid derivatives Bamet-R2 [cis-diamminechloro-cholylglycinate-platinum(II)] and Bamet-UD2 [cis-diammine-bisursodeoxycholate-platinum(II)], developed to treat liver and intestinal tumors, was investigated in vitro using human enterohepatic cells HepG2 (hepatoblastoma), LS 174T (colon adenocarcinoma), and its cisplatin-resistant subline LS 174T/R.
  • The degree of necrosis (lactate dehydrogenase release) induced by these three drugs was small and similar in all cell types.
  • Oral administration of Bamet-UD2 to mice induced mild apoptosis in the small intestine (ileum > duodenum), which was not severe enough to modify its structure or function as determined by water absorption and glycocholic acid uptake by in situ perfused ileum.
  • These results indicate that Bamet-UD2 overcomes the resistance to cisplatin when this is due in part to enhanced ability of intestinal tumors to reduce intracellular cisplatin contents.
  • Moreover, its strong proapoptotic versus its weak pronecrotic effect together with its mild effect on normal tissues, including intestinal mucosa, may account for the high antitumor activity of Bamet-UD2 together with its very low toxicity.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Apoptosis / drug effects. Intestinal Neoplasms / drug therapy. Intestine, Small / drug effects. Organoplatinum Compounds / pharmacology. Ursodeoxycholic Acid / analogs & derivatives

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  • (PMID = 15985617.001).
  • [ISSN] 0022-3565
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Bamet-UD2; 0 / DNA Adducts; 0 / Organoplatinum Compounds; 0 / diamminebis(ursodeoxycholate(O,O'))platinum(II); 724L30Y2QR / Ursodeoxycholic Acid
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11. Caruso S, Marrelli D, Pedrazzani C, Neri A, Mazzei MA, Onorati M, Corso G, Cerullo G, Roviello F: A rare case of primary small bowel adenocarcinoma with intussusception. Tumori; 2010 Mar-Apr;96(2):355-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of primary small bowel adenocarcinoma with intussusception.
  • In contrast with the colon tract, the incidence of primary malignancies in the small bowel is very low.
  • We report the case of a 51-year-old man presenting with jejunal intussusception due to a primary adenocarcinoma.
  • The patient was referred to our division for bowel obstruction.
  • Histological examination of the specimen resulted in a diagnosis of a primary adenocarcinoma of the small bowel.
  • In adult intestinal intussusception, resection without reduction is considered the optimal management if an underlying primary malignancy cannot be excluded.
  • [MeSH-major] Adenocarcinoma / complications. Intussusception / etiology. Jejunal Diseases / etiology. Jejunal Neoplasms / complications

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  • (PMID = 20572601.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Pilleul F, Penigaud M, Milot L, Saurin JC, Chayvialle JA, Valette PJ: Possible small-bowel neoplasms: contrast-enhanced and water-enhanced multidetector CT enteroclysis. Radiology; 2006 Dec;241(3):796-801
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Possible small-bowel neoplasms: contrast-enhanced and water-enhanced multidetector CT enteroclysis.
  • PURPOSE: To prospectively evaluate the sensitivity and specificity of contrast material-enhanced and water-enhanced multidetector computed tomographic (CT) enteroclysis in depicting small-bowel neoplasms in symptomatic patients, with endoscopic, tissue, and follow-up findings as reference standards.
  • Two hundred nineteen patients (108 male, 111 female; age range, 17-98 years; mean, 53.1 years) with clinical suspicion of small-bowel neoplasm underwent contrast- and water-enhanced multidetector CT enteroclysis after normal findings of upper and lower gastrointestinal endoscopy.
  • The prospective interpretations of CT enteroclysis results include evaluation of focal bowel wall thickening, small-bowel masses, small-bowel stenosis, mesenteric stranding, enlarged mesenteric lymph nodes, and visceral metastasis.
  • The overall sensitivity and specificity in identifying patients with small-bowel lesions were 84.7% and 96.9%, respectively.
  • Findings of pathologic examination confirmed small-bowel tumor in 50 patients with carcinoid tumor (n = 19), adenocarcinoma (n = 7), lymphoma (n = 5), jejunal adenoma (n = 9), stromal tumor (n = 5), ectopic pancreas (n = 2), angiomatous mass (n = 2), or metastasis (n = 1).
  • CONCLUSION: Contrast- and water-enhanced multidetector CT enteroclysis had an overall accuracy of 84.7% for depiction of small-bowel neoplasms.
  • [MeSH-major] Intestinal Neoplasms / radiography. Intestine, Small. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Endoscopy, Gastrointestinal. Female. Humans. Iopamidol / analogs & derivatives. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Reference Standards. Sensitivity and Specificity

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  • [Copyright] (c) RSNA, 2006.
  • (PMID = 17053201.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 17E17JBP8L / iomeprol; JR13W81H44 / Iopamidol
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13. Crook DW, Knuesel PR, Froehlich JM, Eigenmann F, Unterweger M, Beer HJ, Kubik-Huch RA: Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel disease. Eur J Gastroenterol Hepatol; 2009 Jan;21(1):54-65
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  • [Title] Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel disease.
  • PURPOSE: The goal of this study was to compare magnetic resonance enterography (MRE) and video capsule endoscopy (VCE) in suspected small bowel disease.
  • MATERIALS AND METHODS: Nineteen patients with suspected small bowel disease participated in a prospective clinical comparison of MRE versus VCE.
  • RESULTS: Small bowel pathologies were found in 15 out of 19 patients: Crohn's disease (n= 5), lymphoma (n= 4), lymphangioma (n= 1), adenocarcinoma (n= 1), postradiation enteropathy (n= 1), NSAID-induced enteropathy (n =1), angiodysplasia (n= 1), and small bowel adhesions (n= 1).
  • MRE revealed 19 extraenteric findings in 11 patients as well as small bowel adhesions not detected on VCE (n= 1).
  • Thus, VCE and MRE appear to be complementary methods which, when used in conjunction, may better characterize suspected small bowel disease.
  • [MeSH-major] Capsule Endoscopy. Intestinal Diseases / diagnosis. Intestine, Small. Magnetic Resonance Imaging / methods

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  • (PMID = 19086147.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] England
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14. Terado Y, Kurata A, Ishida T, Imamura T, Sakamoto A: Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma. Pathol Int; 2010 Oct;60(10):701-5
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  • [Title] Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma.
  • We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male.
  • Adenocarcinoma without stromal invasion was observed adjacent to the small intestinal mucosa.
  • Immunohistochemistry of the adenocarcinoma tissue revealed p53 overexpression and high Ki-67 labeling index as well as positive staining for CD10, cytokeratin 7, and cytokeratin 20.
  • Therefore, the diagnosis of small intestinal adenocarcinoma was made.
  • To our knowledge, this is the first case of small intestinal adenocarcinoma arising in retroperitoneal mature cystic teratoma.
  • A unique feature of this case is that malignant transformation in retroperitoneal mature teratoma arose even in the fully developed intestine.
  • [MeSH-major] Adenocarcinoma / pathology. Neoplasms, Multiple Primary / pathology. Retroperitoneal Neoplasms / pathology. Teratoma / pathology

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  • [Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
  • [ErratumIn] Pathol Int. 2010 Dec;60(12):798
  • (PMID = 20846270.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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15. Tankova L, Berberova M, Damianov N, Tsankov Ts, Kovatchki D: Preoperative diagnosis of jejunal adenocarcinoma--a case report. J BUON; 2008 Jan-Mar;13(1):123-6
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  • [Title] Preoperative diagnosis of jejunal adenocarcinoma--a case report.
  • We report herein the case of a preoperatively diagnosed small bowel adenocarcinoma.
  • An US-guided fine (20 gauge) needle aspiration (FNA) cytology of the mass was performed and showed moderately differentiated adenocarcinoma of intestinal origin.
  • On surgical exploration a jejunal tumor of high consistency was found, located 15 cm distantly from the Treitz ligament, infiltrating up to 2/3 of the bowel circumference and partly obstructing its lumen.
  • The histological evaluation of the resected material showed highly to moderately differentiated adenocarcinoma with 5 regional lymph node metastases.
  • The combination of US with Doppler and FNA established preoperatively the malignant small bowel disease.
  • [MeSH-major] Adenocarcinoma / diagnosis. Jejunal Neoplasms / diagnosis

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  • (PMID = 18404799.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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16. Li S, Li Y, Tang L, Zhao P: Obstructed small bowel ruptured toward the inguinal canal resulting from metastatic colon carcinoma in an irreducible, recurrent inguinal hernia with mesh-plug repair: Report of a case. Eur J Surg Oncol; 2010 Oct;36(10):1012-4
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  • [Title] Obstructed small bowel ruptured toward the inguinal canal resulting from metastatic colon carcinoma in an irreducible, recurrent inguinal hernia with mesh-plug repair: Report of a case.
  • Delayed surgical exploration revealed metastatic cancer with small bowel adhesion to the mesh-plug and perforation.
  • The mesh-plug with adherent tissue was removed through the inguinal incision, and the ruptured small bowel was resected.
  • Histopathology revealed moderately differentiated mucinous adenocarcinoma of the tissue adhering to the prosthetic material corresponding to the original colon cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Hernia, Inguinal / surgery. Intestinal Obstruction / pathology. Intestine, Small / surgery. Sigmoid Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20138732.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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17. Kudo K, Funayama Y, Fukushima K, Shibata C, Takahashi K, Ogawa H, Ueno T, Haneda S, Watanabe K, Koyama A, Hayashi K, Hiwatashi N, Kinouchi Y, Shimosegawa T, Sasaki I: [Carcinoma arising from ileorectal fistula in a patient with Crohn's disease]. Nihon Shokakibyo Gakkai Zasshi; 2007 Oct;104(10):1492-7
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  • A 72-year-old man was given a diagnosis of Crohn's disease in 1976 at age 44, and partial resection of is ileum was performed.
  • Ileocecal resection, partial resection of is small intestine and loop sigmoid colostomy were performed.
  • Endoscopic examination showed a fistula orifice in the rectum and biopsy of the fistula revealed mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Crohn Disease / complications. Ileal Diseases / complications. Intestinal Fistula / complications. Rectal Fistula / complications. Rectal Neoplasms / etiology

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  • (PMID = 17917397.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 12
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18. Fraquelli M, Sciola V, Villa C, Conte D: The role of ultrasonography in patients with celiac disease. World J Gastroenterol; 2006 Feb 21;12(7):1001-4
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  • The aim of the present review was to summarize the current evidence on the role of ultrasonography (US) and doppler-US in the diagnosis of celiac disease.
  • Firstly, case control studies identified some of these US signs and then in a prospective series some of these parameters, due to their high specificity, have been shown to be of value in confirming CD diagnosis, whereas others, due to their high sensitivity, have been demonstrated to be useful in excluding the presence of the disease.
  • The last part of this review will deal with the possible role of US in identifying the most severe and common intestinal complication of CD, i.e. the enteropathy-associated T cell non-Hodgkin lymphoma.
  • [MeSH-minor] Abdomen / blood supply. Abdomen / ultrasonography. Adenocarcinoma / diagnosis. Adenocarcinoma / ultrasonography. Algorithms. Case-Control Studies. Humans. Intestinal Neoplasms / ultrasonography. Intestine, Small / ultrasonography. Lymphoma, Non-Hodgkin / ultrasonography. Prospective Studies. Splanchnic Circulation. Ultrasonography. Ultrasonography, Doppler / methods

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  • [Cites] N Engl J Med. 2002 Jan 17;346(3):180-8 [11796853.001]
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  • (PMID = 16534837.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC4087888
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19. Yokooji T, Murakami T, Yumoto R, Nagai J, Takano M: Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells. J Pharm Pharmacol; 2007 Apr;59(4):513-20
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  • [Title] Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells.
  • The site-specific function of multidrug-resistance-associated proteins (MRPs), especially MRP2 and MRP3, was examined in rat intestine and human colon adenocarcinoma (Caco-2) cells.
  • In contrast, probenecid significantly suppressed both apical and basolateral efflux of DNP-SG in Caco2 cells, though the inhibition was of small magnitude.
  • In conclusion, the efflux of DNP-SG from enterocytes mediated by MRPs exhibited a significant regional difference in rat intestine, indicating possible variability in intestinal bioavailabilities of MRP substrates, depending on their absorption sites along the intestine.
  • [MeSH-major] Glutathione / analogs & derivatives. Intestinal Absorption. Membrane Transport Proteins / metabolism. Multidrug Resistance-Associated Proteins / metabolism
  • [MeSH-minor] Animals. Bile / metabolism. Biological Availability. Biological Transport. Blotting, Western. Caco-2 Cells. Dinitrochlorobenzene. Humans. Ileum / metabolism. Intestinal Mucosa / metabolism. Jejunum / metabolism. Male. Probenecid. Rats. Rats, Sprague-Dawley. Substrate Specificity

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  • (PMID = 17430634.001).
  • [ISSN] 0022-3573
  • [Journal-full-title] The Journal of pharmacy and pharmacology
  • [ISO-abbreviation] J. Pharm. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Transport Proteins; 0 / Multidrug Resistance-Associated Proteins; 0 / multidrug resistance-associated protein 2; 0 / multidrug resistance-associated protein 3; 26289-39-4 / S-(2,4-dinitrophenyl)glutathione; GAN16C9B8O / Glutathione; GE3IBT7BMN / Dinitrochlorobenzene; PO572Z7917 / Probenecid
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20. von Rahden BH, Langner C, Brücher BL, Stein HJ, Sarbia M: No association of primary adenocarcinomas of the small bowel with Epstein-Barr virus infection. Mol Carcinog; 2006 May;45(5):349-52
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  • [Title] No association of primary adenocarcinomas of the small bowel with Epstein-Barr virus infection.
  • Adenocarcinomas of the small bowel comprise a very rare entity, with little knowledge about molecular properties and etiological aspects.
  • We have investigated the prevalence of EBER expression (EBV-encoded small RNAs) in a series of small bowel adenocarcinomas (n=56) utilizing RNA in situ hybridization (EBER-RISH).
  • A surgical series of 82 primary resected gastric (n=36) or cardiac (n=46) adenocarcinomas (TU Munich) was used as control group.
  • None of the 56 small bowel carcinomas exhibited EBER expression whereas in the control group the rate of EBER expression accounted for 4.4% in the group of cardia carcinomas and 8.6% in the group of gastric cancers.
  • These results indicate that EBV infection plays no etiologic role in primary small bowel adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / virology. Epstein-Barr Virus Infections / virology. Herpesvirus 4, Human / genetics. Intestinal Neoplasms / virology. Intestine, Small / virology. Stomach Neoplasms / virology

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16493667.001).
  • [ISSN] 0899-1987
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral
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21. Colleypriest BJ, Farrant JM, Slack JM, Tosh D: The role of Cdx2 in Barrett's metaplasia. Biochem Soc Trans; 2010 Apr;38(2):364-9
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  • Barrett's metaplasia describes the development of a columnar/intestinal phenotype in the squamous oesophageal epithelium and is the major risk factor for oesophageal adenocarcinoma.
  • The homoeotic transcription factor Cdx2 (Caudal-type homeobox 2) has been implicated as a master switch gene for intestine and therefore for Barrett's metaplasia.
  • Normally, Cdx2 expression is restricted to the epithelium of the small and large intestine.
  • Loss of Cdx2 function, or conditional deletion in the intestine, results in replacement of intestinal cells with a stratified squamous phenotype.
  • In addition, Cdx2 is sufficient to provoke intestinal metaplasia in the stomach.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Animals. CDX2 Transcription Factor. Esophageal Neoplasms / genetics. Esophageal Neoplasms / pathology. Humans. Metaplasia / genetics. Models, Biological

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  • (PMID = 20298184.001).
  • [ISSN] 1470-8752
  • [Journal-full-title] Biochemical Society transactions
  • [ISO-abbreviation] Biochem. Soc. Trans.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0300415; United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDX2 Transcription Factor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins
  • [Number-of-references] 72
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22. Bulfoni A: [Primary adenocarcinoma of jejunum with obscure gastrointestinal bleeding]. Clin Ter; 2006 Sep-Oct;157(5):431-4
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  • [Title] [Primary adenocarcinoma of jejunum with obscure gastrointestinal bleeding].
  • [Transliterated title] Adenocarcinoma primitivo del digiuno ad esteriorizzazione con enterorragia.
  • A case of primary small bowel adenocarcinoma is reported because of the rarity of this malignancy.
  • [MeSH-major] Adenocarcinoma. Gastrointestinal Hemorrhage / etiology. Jejunal Neoplasms
  • [MeSH-minor] Capsule Endoscopy. Diagnosis, Differential. Female. Humans. Jejunum / pathology. Middle Aged. Occult Blood. Prognosis

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  • (PMID = 17147051.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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23. Lutz JC, El-Bouihi M, Vidal N, Fricain JC, Robert M, Deminière C, Zwetyenga N: Mandibular metastases from an ileum stromal tumor. Rev Stomatol Chir Maxillofac; 2008 Dec;109(6):399-402
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  • Jaw metastases from the gastrointestinal (GI) tract usually evolve from adenocarcinoma of the esophagus, colon, and rectum.
  • These tumors are thought to arise from Cajal cells in GI tract walls, essential for intestine motor function.
  • The small intestine harbors only 30% of GIST.
  • The patient was treated with imatinib but died 11 months after the diagnosis.
  • DISCUSSION: The prevalence of GIST is low but the true incidence may be higher because of under-diagnosis.
  • GIST should be included in the differential diagnosis of intramandibular tumor in patients with prior or current non-oral malignancy.

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  • (PMID = 19010506.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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24. Overman MJ, Kopetz S, Wen S, Hoff PM, Fogelman D, Morris J, Abbruzzese JL, Ajani JA, Wolff RA: Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma. Cancer; 2008 Oct 15;113(8):2038-45
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  • [Title] Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma.
  • BACKGROUND: Metastatic small bowel adenocarcinoma (SBA) has a poor prognosis.
  • The primary tumor site was the jejunum in 35 patients (43%), duodenum in 30 patients (38%), ileum in 6 patients (8%), and nonspecified small bowel in 9 patients (11%).
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18759326.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platinum Compounds; U3P01618RT / Fluorouracil
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25. Stratopoulos C, Papakonstantinou A, Anagnostopoulos G, Terzis I, Tzimas G, Gourgiotis S, Vamvouka C, Hadjiyannakis E: Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study. Eur J Cancer Care (Engl); 2009 Sep;18(5):466-9
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  • [Title] Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study.
  • However, the coexistence of neurofibromatosis with small-bowel adenocarcinoma is exceedingly rare.
  • We present an uncommon case of neurofibromatosis type 1, involving the small bowel in a 73-year-old man, who was admitted to our department with signs of acute abdomen.
  • These nodules obstructed ileal lumen, while the intestine wall was perforated in one point.
  • Histology revealed neurofibromatosis type 1 with malignant transformation to small-bowel adenocarcinoma.
  • We suggest that adenocarcinoma of small bowel should be considered in the evaluation of acute abdominal pain in neurofibromatosis patients.
  • [MeSH-major] Adenocarcinoma / pathology. Ileal Neoplasms / pathology. Intestine, Small / pathology. Neoplasms, Multiple Primary / pathology. Neurofibromatosis 1 / pathology
  • [MeSH-minor] Abdomen, Acute / etiology. Aged. Follow-Up Studies. Humans. Intestinal Obstruction / etiology. Intestinal Obstruction / pathology. Male. Tomography, X-Ray Computed

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  • (PMID = 19473375.001).
  • [ISSN] 1365-2354
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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26. Losowsky MS: A history of coeliac disease. Dig Dis; 2008;26(2):112-20
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  • Coeliac disease may have an ancient history dating back to the 1st and 2nd centuries AD.
  • Dicke's colleagues, Weijers and Van de Kamer, showed that measurement of stool fat reflected the clinical condition.
  • Histological abnormalities of the lining of the small intestine were demonstrated beyond doubt by Paulley in 1954 and techniques of per-oral biopsy described by Royer in 1955 and Shiner in 1956 afforded reliable diagnosis.
  • Lymphoma, adenocarcinoma and ulceration of the small intestine and a range of immunological disorders are associated.
  • [MeSH-minor] Dermatitis Herpetiformis / etiology. Dermatitis Herpetiformis / history. History, 19th Century. History, 20th Century. History, Ancient. Humans. Intestinal Neoplasms / etiology. Intestinal Neoplasms / history. Intestine, Small / pathology. Lymphoma / etiology. Lymphoma / history. Transglutaminases / metabolism. Ulcer / etiology. Ulcer / history

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  • [Copyright] 2008 S. Karger AG, Basel.
  • (PMID = 18431060.001).
  • [ISSN] 1421-9875
  • [Journal-full-title] Digestive diseases (Basel, Switzerland)
  • [ISO-abbreviation] Dig Dis
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] EC 2.3.2.13 / Transglutaminases
  • [Number-of-references] 96
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27. Kaukinen K, Peräaho M, Lindfors K, Partanen J, Woolley N, Pikkarainen P, Karvonen AL, Laasanen T, Sievänen H, Mäki M, Collin P: Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease. Aliment Pharmacol Ther; 2007 May 15;25(10):1237-45
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  • [Title] Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease.
  • Small intestinal biopsy and bone mineral density were investigated in 2001 and clinical features were followed up until 2005.
  • RESULTS: Thirteen coeliac patients had persistent small intestinal villous atrophy despite maintaining gluten-free diet.
  • In 2005, two of the non-responders had developed symptomatic refractory sprue, one died of lymphoma and one of carcinoid tumour, and one gastric adenocarcinoma was operated.
  • [MeSH-major] Celiac Disease / diet therapy. Intestine, Small / pathology. Lymphoma / etiology
  • [MeSH-minor] Adult. Aged. Atrophy. Female. Humans. Intestinal Mucosa / pathology. Middle Aged. Patient Care

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  • (PMID = 17451570.001).
  • [ISSN] 0269-2813
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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28. Okubo K, Yoshioka S, Asukai K, Hata T, Nakanishi M, Maekawa T, Hama N, Kashiwazaki M, Taniguchi M, Tsujie M, Konishi M, Yano K, Fujimoto T: [A case report of primary adenocarcinoma of small intestine]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2792-4
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  • [Title] [A case report of primary adenocarcinoma of small intestine].
  • This is an account of a case of primary adenocarcinoma of the small intestine with peritoneal dissemination successfully treated with chemotherapy.
  • Abdominal computerized tomography revealed a bowel obstruction with tumor and the remarkable small bowel dilation of oral side of tumor.
  • Pathological diagnosis of the resected specimen was adenocarcinoma with lymph nodes metastasis.
  • The peritoneal dissemination consisted of metastatic adenocarcinoma from small intestine.
  • Primary small intestinal adenocarcinoma is a rare disease, and it is often diagnosed as advanced cancer because of few characteristic symptoms.
  • So carcinoma of the small intestine usually has a poor prognosis.
  • [MeSH-major] Adenocarcinoma / therapy. Intestinal Neoplasms / therapy

  • Hazardous Substances Data Bank. FLUOROURACIL .
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  • (PMID = 21224715.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Organoplatinum Compounds; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 2S9ZZM9Q9V / Bevacizumab; 5VT6420TIG / Oxonic Acid; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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29. Ruiz-Tovar J, Martínez-Molina E, Morales V, Sanjuanbenito A: [Primary small bowel adenocarcinoma]. Cir Esp; 2009 Jun;85(6):354-9
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  • [Title] [Primary small bowel adenocarcinoma].
  • [Transliterated title] Adenocarcinoma primario de intestino delgado.
  • INTRODUCTION: Primary small bowel adenocarcinoma is an uncommon tumour, with non-specific symptoms that cause a delay in the diagnosis and consequently a worse outcome for the patient.
  • MATERIAL AND METHOD: We performed a retrospective study of our experience with 17 patients diagnosed with primary small bowel adenocarcinoma, excluding all the cases suggesting secondary involvement of the small bowel from an adenocarcinoma in other locations.
  • Those with duodenal tumours underwent 4 pancreaticoduodenectomies, 3 gastroenterostomies and 1 diagnostic biopsy; 6 bowel resections with lymphadenectomy, 2 en-bloc resections and 1 by-pass were performed on those with jejuno-ileal tumours.
  • CONCLUSIONS: Curative treatment consists of small bowel resection.
  • [MeSH-major] Adenocarcinoma. Duodenal Neoplasms. Ileal Neoplasms. Jejunal Neoplasms

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  • (PMID = 19344893.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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30. Nakamura K, Higashi T, Yamada M, Imai K, Yamamoto Y: Basophilic intracytoplasmic viral matrix inclusions distributed widely in layer hens affected with avian-leukosis-virus-associated tumours. Avian Pathol; 2007 Feb;36(1):53-8
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  • Basopholic intracytoplasmic viral matrix inclusions (MIs) were widely distributed in the chickens affected with subcutaneous myxoma rhabdomyosarcoma, perineuroma, glioma, intra-abdominal adenocarcinoma, and nephroblastoma.
  • They were also present in the smooth muscle cells of the arteries in the spleen and lungs, in the smooth muscle of the digestive tract muscular layer (crop, oesophagus, proventriculus, gizzard, duodenum, jejunum, ileum, caecum, and large intestine), and in the smooth muscle of the capsule in the ovary and pancreas.
  • They consisted of electron-dense small granules and ring-shaped particles.

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  • (PMID = 17364510.001).
  • [ISSN] 0307-9457
  • [Journal-full-title] Avian pathology : journal of the W.V.P.A
  • [ISO-abbreviation] Avian Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Gibson RJ, Bowen JM, Keefe DM: Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor-bearing DA rats. Int J Cancer; 2005 Sep 1;116(3):464-70
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  • We also determined the protective effects of single large and multiple small doses of palifermin.
  • Tumor-bearing DA rats were treated with a single large (10 mg/kg) dose of palifermin 3 days prior to, or multiple small (3 mg/kg day for 3 days) doses of palifermin or vehicle control prior to, receiving 2 doses of 150 mg/kg irinotecan.
  • Small and large intestinal weights were maintained.
  • Intestinal morphometry was not maintained in palifermin-pretreated rats despite being increased prior to irinotecan treatment.
  • Palifermin pretreatment did not prevent apoptosis that peaked at 6 hr in the jejunum or colon, but prevented apoptosis at 96 hr in the small intestine.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / veterinary. Animals. Female. Fibroblast Growth Factor 7. Keratinocytes. Mammary Neoplasms, Animal / drug therapy. Rats. Survival Analysis

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  • (PMID = 15800945.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Fgf7 protein, rat; 126469-10-1 / Fibroblast Growth Factor 7; 62031-54-3 / Fibroblast Growth Factors; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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32. Choquet P, Calon A, Breton E, Beck F, Domon-Dell C, Freund JN, Constantinesco A: Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice. C R Biol; 2007 Nov;330(11):821-7
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  • In vivo imaging could greatly facilitate these trials, but the small size of the animals is a major limitation for the direct visualization of intestinal tissue.
  • Here we report a method of in vivo imaging of the mouse intestine based on X-ray micro-computed tomography using multiple contrast agents.
  • This method was validated in the model of non-cancerous polyp-like heteroplasia that spontaneously develops in the caecum area of Cdx2+/- mutant mice and in the model of colon adenocarcinoma induced by administration of the chemical carcinogen azoxymethane.
  • As a simple and non-invasive method, multiple-contrast X-ray micro-computed tomography is appropriate for pre-clinical studies of intestinal diseases in living mice.
  • [MeSH-minor] Animals. Equipment Design. Heterozygote. Homeodomain Proteins / genetics. Intestinal Diseases / radiography. Male. Mice. Mice, Knockout. Transcription Factors / deficiency. Transcription Factors / genetics

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  • (PMID = 17923376.001).
  • [ISSN] 1631-0691
  • [Journal-full-title] Comptes rendus biologies
  • [ISO-abbreviation] C. R. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Cdx2 protein, mouse; 0 / Homeodomain Proteins; 0 / Transcription Factors
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33. Posey JA 3rd, Saif MW, Carlisle R, Goetz A, Rizzo J, Stevenson S, Rudoltz MS, Kwiatek J, Simmons P, Rowinsky EK, Takimoto CH, Tolcher AW: Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas. Clin Cancer Res; 2005 Nov 1;11(21):7866-71
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  • Unconfirmed partial responses were observed in two patients, one with metastatic small bowel adenocarcinoma and the other with metastatic esophageal cancer.

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  • (PMID = 16278410.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR00032
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 30IQX730WE / Polyethylene Glycols; 581079-18-7 / pegamotecan; XT3Z54Z28A / Camptothecin
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34. Ausloos F, Scagnol I, Belaiche J: [Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report]. Rev Med Liege; 2009 Jul-Aug;64(7-8):394-7
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  • [Title] [Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report].
  • [Transliterated title] Adénocarcinome de l'intestin grêle compliquant une maladie coeliaque de l'adulte: à propos d'un cas.
  • This small bowel adenocarcinoma is rare and concerns less than 5% of the digestive neoplasias.
  • We are reporting the case of a 67-years-old woman whose coeliac disease has been complicated 5 years thereafter by a jejunal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Celiac Disease / complications. Incidental Findings. Jejunal Neoplasms / complications. Jejunal Neoplasms / diagnosis

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  • (PMID = 19777919.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
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35. Su MC, Yuan RH, Lin CY, Jeng YM: Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system. Mod Pathol; 2008 Nov;21(11):1379-86
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  • [Title] Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system.
  • Cadherin-17, also called liver-intestine cadherin, is a calcium-dependent transmembrane glycoprotein that mediates cell-cell adhesion in intestinal epithelium.
  • Expression of cadherin-17 was reported in gastric, pancreatic, and colorectal adenocarcinomas but not in other tumors.
  • Whether cadherin-17 can be used as a marker for diagnosis of cancers is still unclear.
  • Among normal tissues, the expression of cadherin-17 was limited to epithelial cells of small intestine and colon.
  • Colorectal adenocarcinomas showed staining in 96% of cases and most of them had strong and diffuse staining.
  • Gastric, pancreatic, and biliary adenocarcinomas showed diffuse or scattered staining in about 25-50% of cases.
  • When a two-marker, Cadherin-17/cytokeratin 7, profile was used, 37 of 38 (97%) cadherin-17(+)/cytokeratin 7(-) tumors were colorectal adenocarcinomas; 49 of 56 (86%) cadherin-17(+)/cytokeratin 7(+) tumors were gastric, pancreatic, or biliary adenocarcinomas.
  • Our results show that cadherin-17 is a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Cadherins / analysis. Gastrointestinal Neoplasms / diagnosis
  • [MeSH-minor] Colorectal Neoplasms / chemistry. Colorectal Neoplasms / diagnosis. Female. Humans. Immunoenzyme Techniques. Male. Pancreatic Neoplasms / chemistry. Pancreatic Neoplasms / diagnosis. Stomach Neoplasms / chemistry. Stomach Neoplasms / diagnosis

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  • (PMID = 18552820.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDH17 protein, human; 0 / Cadherins
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36. Uchiyama S, Itoh H, Naganuma S, Nagaike K, Fukushima T, Tanaka H, Hamasuna R, Chijiiwa K, Kataoka H: Enhanced expression of hepatocyte growth factor activator inhibitor type 2-related small peptide at the invasive front of colon cancers. Gut; 2007 Feb;56(2):215-26
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  • [Title] Enhanced expression of hepatocyte growth factor activator inhibitor type 2-related small peptide at the invasive front of colon cancers.
  • BACKGROUND: Hepatocyte growth factor activator inhibitor type 2-related small peptide (H2RSP) is a small nuclear protein abundantly expressed in the gastrointestinal epithelium.
  • AIMS: To investigate the expression and localisation of H2RSP in normal, injured and neoplastic human intestinal tissue.
  • METHODS: Immunohistochemical examination and in situ hybridisation for H2RSP were performed using normal and diseased intestinal specimens.
  • RESULTS: In the normal intestine, H2RSP was observed in the nuclei of surface epithelial cells and this nuclear localisation was impaired in regenerating epithelium.
  • H2RSP expression was down regulated in well-differentiated colorectal adenocarcinomas.
  • The number of H2RSP-positive cells in the invasive front of well-differentiated adenocarcinomas was considerably higher in the cases with lymph node metastases than in node-negative ones.
  • CONCLUSION: In the normal intestine, the nuclear accumulation of H2RSP is a marker of differentiated epithelial cells.
  • Although H2RSP was down regulated in colorectal adenocarcinomas, a paradoxical up regulation was observed in actively invading carcinoma cells.
  • [MeSH-major] Adenocarcinoma / chemistry. Colonic Neoplasms / chemistry. Neoplasm Proteins / analysis. Nuclear Proteins / analysis. Transcription Factors / analysis
  • [MeSH-minor] Adenoma / chemistry. Adenoma / immunology. Adenoma / pathology. Animals. CHO Cells. Cell Count. Cell Differentiation / physiology. Cell Division / physiology. Cell Line, Tumor. Colitis, Ulcerative / immunology. Colitis, Ulcerative / pathology. Colorectal Neoplasms / chemistry. Colorectal Neoplasms / immunology. Colorectal Neoplasms / pathology. Cricetinae. Cricetulus. Epithelial Cells / chemistry. Epithelial Cells / immunology. Epithelial Cells / pathology. Humans. Hyperplasia. Immunohistochemistry / methods. In Situ Hybridization / methods. Intestinal Polyps / chemistry. Intestinal Polyps / immunology. Intestinal Polyps / pathology. Intestines / chemistry. Intestines / immunology. Intestines / pathology. Lymphatic Metastasis. Neoplasm Invasiveness. beta Catenin / analysis

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  • (PMID = 16809422.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / C19orf33 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / beta Catenin
  • [Other-IDs] NLM/ PMC1856747
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37. Yamaga Y, Ohana M, Nakamura T, Kikuchi S, Matsumura K, Takita M, Iwamoto S, Morisawa T, Miyajima S, Kida H, Okano A, Okinaga S, Kusumi F, Takakuwa H, Honjou G: [A case of jejunal adenocarcinoma with serum DUPAN-2 elevation]. Nihon Shokakibyo Gakkai Zasshi; 2010 Nov;107(11):1806-13
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  • [Title] [A case of jejunal adenocarcinoma with serum DUPAN-2 elevation].
  • Ileus with ulcerated jejunal tumor was diagnosed and biopsy revealed adenocarcinoma.
  • Surgical resection was performed: both tumors were adenocarcinoma, but the ovarian tumor was considered to be metastatic clinically and histologically.
  • This case shows a possible relation between small bowel adenocarcinoma and DUPAN-2.
  • [MeSH-major] Adenocarcinoma / diagnosis. Antigens, Neoplasm / blood. Jejunal Neoplasms / diagnosis

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  • (PMID = 21071898.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DU-PAN-2 antigen, human
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38. Bilici A, Karadag B, Doventas A, Seker M: Gastric pneumatosis intestinalis associated with malignancy: an unusual case report. World J Gastroenterol; 2009 Feb 14;15(6):758-60
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  • The most common localization is the small intestine.
  • We report on a 94-year-old man with gastric PI associated with inoperable adenocarcinoma localized in the duodenum.
  • We suggest that in patients presenting with PI, malignancy should be considered in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Duodenal Neoplasms / diagnosis. Pneumatosis Cystoides Intestinalis / diagnosis. Pneumatosis Cystoides Intestinalis / radiography
  • [MeSH-minor] Aged, 80 and over. Blood Proteins / analysis. Blood Proteins / isolation & purification. Diagnosis, Differential. Fatal Outcome. Humans. Male. Stomach Diseases / diagnosis. Stomach Diseases / etiology. Stomach Diseases / radiography. Tomography, X-Ray Computed. Urine / cytology

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  • (PMID = 19222105.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Blood Proteins
  • [Other-IDs] NLM/ PMC2653449
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39. Gayoso MJ, Muñoz R, Arias Y, Villar R, Rojo MA, Jiménez P, Ferreras JM, Aranguez I, Girbés T: Specific dose-dependent damage of Lieberkühn crypts promoted by large doses of type 2 ribosome-inactivating protein nigrin b intravenous injection to mice. Toxicol Appl Pharmacol; 2005 Sep 1;207(2):138-46
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  • As a consequence of the injury, the villi and crypt structures of the small intestine disappeared, leading to profuse bleeding and death.
  • In both cases, lethal and sub-lethal doses, the target of nigrin b appeared to be the highly proliferating stem cells of the intestinal crypts, which had undergone apoptotic changes.
  • Nigrin b killed COLO 320 human colon adenocarcinoma cells with an IC(50) of 3.1 x 10(-8) M and the effect was parallel to the extent of DNA fragmentation of these cells.
  • Accordingly, despite the low general toxicity exerted by nigrin b as compared with ricin, intravenous injection of large amounts of nigrin b is able to kill mouse intestinal stem cells without threatening the lives of the animals, thereby opening a door for its use for the targeting of intestinal stem cells.
  • [MeSH-major] Intestine, Small / drug effects. N-Glycosyl Hydrolases / toxicity. Plant Proteins / toxicity

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  • (PMID = 16102565.001).
  • [ISSN] 0041-008X
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Proteins; 0 / Ribosome Inactivating Proteins, Type 2; 9009-86-3 / Ricin; EC 3.2.2.- / N-Glycosyl Hydrolases
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40. Ashman JB, Zelefsky MJ, Hunt MS, Leibel SA, Fuks Z: Whole pelvic radiotherapy for prostate cancer using 3D conformal and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys; 2005 Nov 1;63(3):765-71
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  • METHODS AND MATERIALS: Between December 1996 and January 2002, 27 patients with prostate adenocarcinoma were treated with conformal WPRT as part of their definitive treatment.
  • Dose-volume histograms for the bowel, bladder, and rectum were compared for the three techniques.
  • RESULTS: Three-dimensional-CRT resulted in a 40% relative reduction (p < 0.001) in the volume of bowel receiving 45 Gy compared with 2D, and IMRT provided a further 60% reduction relative to 3D-CRT (p < 0.001).
  • CONCLUSIONS: Compared to conventional 2D planning, conformal planning for WPRT resulted in significant reductions in the doses delivered to the bowel, rectum, and bladder.
  • IMRT was superior to 3D-CRT in limiting the volume of bowel and rectum within high-dose regions.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colon / radiation effects. Diarrhea / etiology. Humans. Intestine, Small / radiation effects. Male. Middle Aged. Pelvis. Radiation Dosage. Radiotherapy, Intensity-Modulated / adverse effects. Radiotherapy, Intensity-Modulated / methods. Rectum / radiation effects. Urinary Bladder / radiation effects. Urination Disorders / etiology


41. Fishman PN, Pond GR, Moore MJ, Oza A, Burkes RL, Siu LL, Feld R, Gallinger S, Greig P, Knox JJ: Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases. Am J Clin Oncol; 2006 Jun;29(3):225-31
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  • [Title] Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases.
  • BACKGROUND: Small bowel adenocarcinoma is a rare cancer that has generally been considered resistant to chemotherapy, although little has been published on the role of chemotherapy.
  • A retrospective analysis was conducted of patients with advanced small bowel adenocarcinoma to explore chemotherapy use, and gain knowledge for ongoing management and future clinical trials.
  • PATIENTS AND METHODS: All patients with advanced adenocarcinoma of the small bowel treated at Princess Margaret Hospital (PMH) between 1986 and 2004 were identified through the cancer registry.
  • CONCLUSION: Chemotherapy appears to have activity in adenocarcinoma of the small bowel.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestinal Neoplasms / pathology

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  • (PMID = 16755174.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Kalogerinis PT, Poulos JE, Morfesis A, Daniels A, Georgakila S, Daignualt T, Georgakilas AG: Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective. BMC Gastroenterol; 2010;10:109
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  • BACKGROUND: There is very small occurrence of adenocarcinoma in the small bowel.
  • We present a case of primary duodenal adenocarcinoma and discuss the findings of the case diagnostic modalities, current knowledge on the molecular biology behind small bowel neoplasms and treatment options.
  • CASE: The patient had a history of iron deficiency anemia and occult bleeding with extensive workup consisting of upper endoscopy, colonoscopy, capsule endoscopy, upper gastrointestinal series with small bowel follow through and push enteroscopy.
  • Due to persistent abdominal pain and iron deficiency anemia the patient underwent push enteroscopy which revealed adenocarcinoma of the duodenum.
  • The patient underwent en-bloc duodenectomy which revealed T3N1M0 adenocarcinoma of the 4th portion of the duodenum.
  • CONCLUSIONS: Primary duodenal carcinoma, although rare should be considered in the differential diagnosis of occult gastrointestinal bleeding when evaluation of the lower and upper GI tract is unremarkable.
  • We discuss the current evaluation and management of this small bowel neoplasm.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Duodenal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Duodenoscopy. Female. Humans. Laparotomy. Ligaments. Tomography, X-Ray Computed

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  • (PMID = 20849628.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2949773
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43. Olschwang S, Bonaïti-Pellié C, Feingold J, Frébourg T, Grandjouan S, Lasset C, Laurent-Puig P, Lecuru F, Millat B, Sobol H, Thomas G, Eisinger F: [Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer), hereditary predisposition to colorectal and endometrial adenocarcinomas]. Pathol Biol (Paris); 2006 May;54(4):215-29
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  • [Title] [Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer), hereditary predisposition to colorectal and endometrial adenocarcinomas].
  • [Transliterated title] Identification et prise en charge du syndrome HNPCC (hereditary non polyposis colon cancer). Prédisposition héréditaire aux cancers du côlon, du rectum et de l'utérus.
  • Patients affected by the disease are at high risk for colorectal and endometrial carcinomas, but also for small intestine, urothelial, ovary, stomach and biliary tract carcinomas.
  • [MeSH-major] Adenocarcinoma / genetics. Colonic Neoplasms / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Endometrial Neoplasms / genetics. Rectal Neoplasms / genetics


44. Aurello P, Dente M, D'Angelo F, Nigri G, Cescon M, Ramacciato G: Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient. Am Surg; 2009 Feb;75(2):189-90
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  • [Title] Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient.
  • [MeSH-major] Adenocarcinoma / pathology. Crohn Disease / etiology. Ileal Neoplasms / pathology. Intestinal Obstruction / etiology


45. Bergmann F, Singh S, Michel S, Kahlert C, Schirmacher P, Helmke B, Von Knebel Doeberitz M, Kloor M, Bläker H: Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway. Oncol Rep; 2010 Dec;24(6):1535-9
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  • [Title] Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway.
  • Celiac disease (CD) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma.
  • We hypothesized that CIM may link CD to small bowel carcinogenesis.
  • We determined microsatellite instability (MSI), CIM, and expression of MLH1 and MGMT in 3 CD-associated small bowel carcinomas and corresponding non-neoplastic mucosa.
  • The results were compared to those of small bowel mucosa from CD patients without carcinoma and 20 small bowel carcinomas from a non-CD origin.
  • In conclusion, our data reveal that the high-level CIM/MSI pathway is typical of CD-associated small bowel carcinomas and indicate that aberrant CpG island methylation links CD and carcinogenesis.
  • The data further suggest that CD should be considered in patients with small bowel adenocarcinoma, particularly when the tumors display MSI.
  • [MeSH-major] Adenocarcinoma / genetics. Celiac Disease / genetics. CpG Islands. DNA Methylation. Intestinal Neoplasms / genetics. Microsatellite Instability
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adult. Aged. Aged, 80 and over. Cohort Studies. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Humans. Intestinal Mucosa / metabolism. Intestinal Mucosa / pathology. Intestine, Small / metabolism. Intestine, Small / pathology. Male. Middle Aged. Nuclear Proteins / genetics. Signal Transduction / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 21042749.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
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46. Kodaira C, Osawa S, Mochizuki C, Sato Y, Nishino M, Yamada T, Takayanagi Y, Takagaki K, Sugimoto K, Kanaoka S, Furuta T, Ikuma M: A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy. World J Gastroenterol; 2009 Apr 14;15(14):1774-8
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  • [Title] A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy.
  • Small bowel adenocarcinoma (SBA) in patients with Crohn's disease (CD) is quite rare, difficult to diagnose without surgery, and has a poor prognosis.
  • PET/CT detected an accumulation spot in the small bowel.
  • An endoscopic forceps biopsy specimen showed poorly differentiated adenocarcinoma.
  • There were some longitudinal ulcer scars near the tumor, and the chronic inflammation in the small bowel appeared to be associated with the cancer development.
  • Since early diagnosis is extremely difficult in these cases, novel techniques, such as PET/CT and DBE, may be expected to help in making a preoperative diagnosis of the development of SBA in CD.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / etiology. Crohn Disease / complications. Endoscopy, Gastrointestinal / methods. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / etiology. Intestine, Small / pathology

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  • (PMID = 19360924.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2668786
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47. Simmen FA, Frank JA, Wu X, Xiao R, Hennings LJ, Prior RL: Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon. BMC Gastroenterol; 2009 Sep 16;9:67
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  • [Title] Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon.
  • METHODS: We examined efficacy of BB in inhibition of azoxymethane (AOM)-induced colon ACF and intestine tumors in male and female Sprague-Dawley rats (outbred strain).
  • There was a tendency (0.1 > P > 0.05) for fewer adenocarcinomas (relative to total of adenomatous polyps plus adenocarcinomas) in colons of female than male tumor-bearing rats; in small intestine, this gender difference was significant (P < 0.05).
  • BB favored (P < 0.05) fewer adenocarcinomas and more adenomatous polyps (as a proportion of total tumor number) in female rat small intestine.
  • Data indicate the potential for slowing tumor progression (adenomatous polyp to adenocarcinoma) by BB.

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  • (PMID = 19758446.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CB / N02-CB-07008
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / C-Peptide; MO0N1J0SEN / Azoxymethane
  • [Other-IDs] NLM/ PMC2752457
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48. Chang HK, Yu E, Kim J, Bae YK, Jang KT, Jung ES, Yoon GS, Kim JM, Oh YH, Bae HI, Kim GI, Jung SJ, Gu MJ, Kim JY, Jang KY, Jun SY, Eom DW, Kwon KW, Kang GH, Park JB, Hong S, Lee JS, Park JY, Hong SM, Korean Small Intestinal Cancer Study Group: Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases. Hum Pathol; 2010 Aug;41(8):1087-96
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  • [Title] Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases.
  • Small intestinal adenocarcinoma is a rare malignant neoplasm, and its clinicopathologic characteristics have not been well elucidated.
  • A total of 197 small intestinal adenocarcinoma cases were collected from 22 institutions in South Korea and were evaluated for clinicopathologic factors that affect the prognosis of small intestinal adenocarcinoma patients using univariate and multivariate analyses.
  • The median survival time for all small intestinal adenocarcinoma patients was 39.7 months.
  • Compared with small intestinal adenocarcinomas without accompanying sporadic adenomas, small intestinal adenocarcinomas with accompanying adenomas were more well differentiated (P < .0001), with a more polypoid growth pattern (P < .0001), a lower pT classification (P < .0001), less perineural invasion (P = .01), and less lymphatic invasion (P = .03).
  • Small intestinal adenocarcinoma patients with associated sporadic adenomas (77%) had a significantly better 5-year survival rate than those without sporadic adenomas (38%, P = .02).
  • By univariate analysis, small intestinal adenocarcinoma patients had significantly different survival based on pT classification (P = .003), lymph node metastasis (P < .0001), distal location (jejunal and ileal carcinomas) (P = .003), retroperitoneal tumor seeding (P < .0001), vascular invasion (P = .007), lymphatic invasion (P = .001), peritumoral dysplasia (P = .004), and radiation therapy (P = .006).
  • In conclusion, (1) small intestinal adenocarcinomas are diagnosed at an advanced disease stage; therefore, the development of strategies for detection at an earlier stage is needed. (2) Small intestinal adenocarcinoma patients with an adenomatous component had a better survival than those without an adenomatous component. (3) Lymph node metastasis and distal location (jejunum and ileum) of tumor are the most important independent prognostic factors.
  • [MeSH-major] Adenocarcinoma / pathology. Duodenal Neoplasms / pathology. Ileal Neoplasms / pathology. Jejunal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intestine, Small / pathology. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Prognosis

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20334897.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Janot MS, Kersting S, Chromik AM, Tannapfel A, Uhl W: [Amyloidosis of the small intestine following whipple operation is a rare cause of chronic ileus and has to be considered as differential diagnosis]. Zentralbl Chir; 2010 Aug;135(4):345-9
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  • [Title] [Amyloidosis of the small intestine following whipple operation is a rare cause of chronic ileus and has to be considered as differential diagnosis].
  • [Transliterated title] Die Amyloidose des Dünndarms als seltene Differenzialdiagnose eines chronischen Ileus nach Whipple-Operation.
  • In this paper we report that secondary amyloidosis of the small intestine can produce similar symptoms and has to be evaluated as a rare differential diagnosis in chronic ileus.
  • Instead severe adhesions of the small intestine were detected.
  • The entire small intestine was covered with a substance that had a similar aspect to sugar icing.
  • Thereby the motility of the small intestine was constricted.
  • An extensive adhaesiolysis and a decompression of the bowel was carried out.
  • Diffuse amyloid deposits were found on the small intestine.
  • One man died four months later, after transfer to a geriatric hospital, because of intestinal atony and a serious senile depression.
  • Surgeons have to keep in mind that amyloidosis is a possible differential diagnosis in addition to relapse of tumour growth and peritoneal carcinomatosis in these patients.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Amyloidosis / diagnosis. Cystadenoma, Mucinous / surgery. Ileus / diagnosis. Intestinal Diseases / diagnosis. Intestine, Small. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Postoperative Complications / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Chronic Disease. Diagnosis, Differential. Fatal Outcome. Female. Humans. Male. Tissue Adhesions / diagnosis. Tissue Adhesions / pathology. Tissue Adhesions / surgery

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  • [Copyright] Georg Thieme Verlag Stuttgart ˙ New York.
  • (PMID = 20464655.001).
  • [ISSN] 1438-9592
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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50. Yamada K, Ikehara Y, Nakanishi H, Kozawa E, Tatematsu M, Sugiura H: Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma. J Orthop Sci; 2007 Nov;12(6):606-10
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  • [Title] Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma.
  • [MeSH-major] Acetabulum. Adenocarcinoma / secondary. Bone Neoplasms / secondary. Jejunal Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed

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  • (PMID = 18040646.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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51. Sakai Y, Tsuyuguchi T, Ohara T, Yukisawa S, Tsuchiya S, Sugiyama H, Miyakhawa K, Ohbu M, Kato K, Kimura M, Kaiho T, Takeuchi O, Matsuzaki O, Miyazaki M, Yokosuka O: A patient with adenocarcinoma of the jejunum successfully diagnosed by preoperative endoscopy for the small intestine. Hepatogastroenterology; 2008 Jul-Aug;55(85):1367-9
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  • [Title] A patient with adenocarcinoma of the jejunum successfully diagnosed by preoperative endoscopy for the small intestine.
  • In this study, the authors report the case of a 35-year-old man diagnosed preoperatively as having adenocarcinoma of the jejunum using a conventional endoscopy, usually used for the examination of the large intestine.
  • [MeSH-major] Adenocarcinoma / pathology. Endoscopy. Jejunal Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Ileus / diagnosis. Ileus / etiology. Ileus / surgery. Intestine, Small. Male

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  • (PMID = 18795691.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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52. France M, Drew PA, Ruszkiewicz A, Jamieson GG, Watson DI: Use of ethylenediaminetetraacetic acid for in vivo stripping of columnar mucosa: pilot study in an experimental model. ANZ J Surg; 2006 May;76(5):392-7
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  • BACKGROUND: Barrett's oesophagus is an important clinical problem that can lead to oesophageal adenocarcinoma.
  • To determine the feasibility of using EDTA to strip intestinal type mucosa, segments of the small intestine were exposed in vitro to EDTA at various concentrations with or without agitation.
  • The conditions required for EDTA to strip mucosa from a vascularized loop of small bowel were then optimized in vivo.
  • Cannulated small bowel loops were irrigated with different concentrations of EDTA with or without pulsation of the irrigation solution.
  • Mucosal healing after EDTA stripping was studied in an isolated small bowel loop survival model.
  • RESULTS: Ethylenediaminetetraacetic acid with agitation or pulsation resulted in stripping of the intestinal columnar mucosa in vitro and in vivo.
  • In the survival model the small bowel mucosa regenerated without stricture formation.
  • CONCLUSION: Small bowel columnar mucosa can be removed by EDTA in vivo without stricture formation.
  • [MeSH-major] Chelating Agents / pharmacology. Edetic Acid / pharmacology. Esophagus / drug effects. Intestinal Mucosa / drug effects. Jejunum / drug effects

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  • (PMID = 16768702.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Chelating Agents; 9G34HU7RV0 / Edetic Acid
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53. Versaci A, Macrì A, Ieni A, Terranova M, Leonello G, Saladino E, Speciale G, Famulari C: [Gastrointestinal stromal tumour: our experience]. Chir Ital; 2009 Mar-Apr;61(2):161-9
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  • These tumours originate in Cajal interstitial cells and the majority are located in the stomach and small intestine.
  • Imaging difficulties impede an early diagnosis; sometimes these tumours represent an unexpected intraoperative finding or an emergency abdominal picture.
  • One patient, with two synchronous gastric neoplasms (GIST + adenocarcinoma) died after 16 months, while the other 5 patients with gastric GIST are still alive; two patients with ileal GIST, treated with chemotherapy, died after 15 and 18 months, respectively.

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  • (PMID = 19536989.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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54. Michalopoulos A, Papadopoulos V, Paramythiotis D, Papavramidis T, Douros V, Netta S, Mekras A, Apostolidis S: Colonic cancer in a patient with intestinal malrotation: a case report. Tech Coloproctol; 2010 Nov;14 Suppl 1:S65-6
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  • [Title] Colonic cancer in a patient with intestinal malrotation: a case report.
  • We present a case of a 76-year-old patient with intestinal malrotation, with incomplete rotation of the small intestine and abnormal positioning of the duodenum and superior mesenteric vessels over the transverse colon.
  • [MeSH-major] Adenocarcinoma / complications. Colonic Neoplasms / complications. Digestive System Abnormalities / complications. Intestinal Diseases / congenital. Intestines / abnormalities

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  • (PMID = 20683743.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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55. Triantafillidis JK, Nasioulas G, Kosmidis PA: Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res; 2009 Jul;29(7):2727-37
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  • [Title] Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.
  • Patients with long-standing ulcerative colitis and Crohn's disease have an increased risk of developing colorectal cancer and patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.
  • Colorectal cancer appearing on the ground of inflammatory bowel disease is the result of a process which is believed to begin from no dysplasia progressing to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma, although colorectal cancer can arise without proceeding through each of these steps.
  • [MeSH-major] Cell Transformation, Neoplastic. Colorectal Neoplasms / epidemiology. Inflammatory Bowel Diseases / epidemiology

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  • (PMID = 19596953.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Number-of-references] 94
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56. Ko S, Chu KM, Luk JM, Wong BW, Yuen ST, Leung SY, Wong J: CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach. J Pathol; 2005 Apr;205(5):615-22
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  • [Title] CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach.
  • CDX2 and liver-intestine (LI)-cadherin are intestine-specific markers and both are physiologically expressed in the small intestine and colon.
  • Overexpression of CDX2 was significantly associated with CDH17 in gastric adenocarcinoma.
  • Furthermore, the expression of CDX2 and LI-cadherin proteins was strongly coupled in intestinal metaplasia.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Cadherins / metabolism. Homeodomain Proteins / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 15732140.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDH17 protein, human; 0 / CDX2 protein, human; 0 / Cadherins; 0 / Homeodomain Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger
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57. Overman MJ, Hu CY, Wolff RA, Chang GJ: Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database. Cancer; 2010 Dec 1;116(23):5374-82
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  • [Title] Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database.
  • BACKGROUND: The presence of distant metastases and the completeness of resection are important prognostic factors in patients with small bowel adenocarcinoma (SBA); however, the influence of lymph node metastasis on patient outcome has not been well characterized.
  • [MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small. Lymph Nodes / pathology

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  • [Copyright] Copyright © 2010 American Cancer Society.
  • (PMID = 20715162.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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58. Nagai S, Mimuro H, Yamada T, Baba Y, Moro K, Nochi T, Kiyono H, Suzuki T, Sasakawa C, Koyasu S: Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci U S A; 2007 May 22;104(21):8971-6
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  • Helicobacter pylori is a Gram-negative spiral bacterium that causes gastritis and peptic ulcer and has been implicated in the pathogenesis of gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma.
  • We demonstrate here that Peyer's patches (PPs) in the small intestine play critical roles in H. pylori-induced gastritis; no gastritis is induced in H. pylori-infected mice lacking PPs.
  • We propose that H. pylori converts to the coccoid form in the anaerobic small intestine and stimulates the host immune system through PPs.

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  • (PMID = 17502608.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Bacterial; 0 / DNA-Binding Proteins; 0 / Rag2 protein, mouse
  • [Other-IDs] NLM/ PMC1885612
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59. Palascak-Juif V, Bouvier AM, Cosnes J, Flourié B, Bouché O, Cadiot G, Lémann M, Bonaz B, Denet C, Marteau P, Gambiez L, Beaugerie L, Faivre J, Carbonnel F: Small bowel adenocarcinoma in patients with Crohn's disease compared with small bowel adenocarcinoma de novo. Inflamm Bowel Dis; 2005 Sep;11(9):828-32
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  • [Title] Small bowel adenocarcinoma in patients with Crohn's disease compared with small bowel adenocarcinoma de novo.
  • BACKGROUND: Data concerning small bowel adenocarcinoma (SBA) in Crohn's disease (CD) come from case reports and small retrospective series.
  • The aim of this study was to further describe SBA in patients with CD and compare it with SBA de novo.
  • METHODS: Twenty patients with CD with SBA recruited in French university hospitals were studied and compared with 40 patients with SBA de novo recruited from a population-based registry.
  • SBA occurred after a median time of 15 years of CD and was located within the inflamed areas of the ileum (n=19) or jejunum (n=1), whereas in patients with SBA de novo, it was distributed all along the small intestine.
  • Median age at diagnosis of SBA was 47 years (range, 33-72 yr) in patients with CD and 68 years (range, 41-95 yr) in those with SBA de novo.
  • Diagnosis was made preoperatively in 1/20 patients with CD and 22/40 patients with SBA de novo.
  • Signet ring cells were found in 35% of patients with CD but not in patients with SBA de novo.
  • CONCLUSIONS: SBA in CD is different from SBA de novo.
  • [MeSH-major] Adenocarcinoma / pathology. Crohn Disease / complications. Ileal Neoplasms / pathology


60. Farrell S, Gray SB, Best BG: Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature. Int Surg; 2005 Apr-Jun;90(2):85-7
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  • [Title] Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature.
  • Primary adenocarcinoma of the ileum is an uncommon gastrointestinal malignancy, the symptoms of which are often insidious in onset.
  • This case history highlights the previously unreported finding of ileal adenocarcinoma presenting with mucusuria, caused by local invasion of the bladder in a 44-year-old male.
  • A review of the literature is included to highlight the incidence, risk factors, clinical presentation, investigation, and current management of adenocarcinoma of the small bowel.
  • [MeSH-major] Adenocarcinoma / secondary. Ileal Neoplasms / pathology. Intestinal Fistula / diagnosis. Urinary Bladder Fistula / diagnosis. Urinary Bladder Neoplasms / secondary

  • MedlinePlus Health Information. consumer health - Bladder Cancer.
  • MedlinePlus Health Information. consumer health - Intestinal Cancer.
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  • (PMID = 16119711.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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61. Vagholkar K, Mathew T: Adenocarcinoma of the small bowel: a surgical dilemma. Saudi J Gastroenterol; 2009 Oct-Dec;15(4):264-7
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  • [Title] Adenocarcinoma of the small bowel: a surgical dilemma.
  • Malignant tumors of the small intestine are among the rarest types of gastrointestinal cancers.
  • Due to their infrequent occurrence and the multitude of tumor types (viz, adenocarcinomas, carcinoids, sarcomas, and lymphomas), not much is known about their natural history and presentation, and there is often delay in the diagnosis.
  • Adenocarcinoma is the commonest histologic type of small bowel cancer.
  • In this article, a case of adenocarcinoma of the jejunum presenting as an abdominal lump is presented, along with a review of the literature.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Jejunal Neoplasms / pathology. Jejunal Neoplasms / surgery

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62. Bruckner HW, Hrehorovich VR, Sawhney HS, Meeus SI, Coopeman AM: Chemotherapeutic management of small bowel adenocarcinoma associated with Crohn's disease. J Chemother; 2006 Oct;18(5):545-8
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  • [Title] Chemotherapeutic management of small bowel adenocarcinoma associated with Crohn's disease.
  • Four patients with metastatic primary small bowel adenocarcinoma associated with Crohn's disease were successfully treated with low dose combination chemotherapy consisting of 5-fluorouracil, leucovorin and irinotecan with or without gemcitabine.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Crohn Disease / complications. Duodenal Neoplasms / drug therapy. Ileal Neoplasms / drug therapy. Jejunal Neoplasms / drug therapy
  • [MeSH-minor] Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Female. Humans. Intestine, Small / pathology. Leucovorin / administration & dosage. Male. Remission Induction. Survival Analysis


63. Yakan S, Caliskan C, Makay O, Denecli AG, Korkut MA: Intussusception in adults: clinical characteristics, diagnosis and operative strategies. World J Gastroenterol; 2009 Apr 28;15(16):1985-9
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  • [Title] Intussusception in adults: clinical characteristics, diagnosis and operative strategies.
  • AIM: To evaluate 20 adults with intussusception and to clarify the cause, clinical features, diagnosis, and management of this uncommon entity.
  • METHODS: A retrospective review of patients aged > 18 years with a diagnosis of intestinal intussusception between 2000 and 2008.
  • The majority of intussusceptions were in the small intestine (85%).
  • Among enteric intussusceptions, 14 were secondary to a benign process, and in one of these, the malignant cause was secondary to metastatic lung adenocarcinoma.
  • Treatment usually requires resection of the involved bowel segment.
  • Reduction can be attempted in small-bowel intussusception if the segment involved is viable or malignancy is not suspected; however, a more careful approach is recommended in colonic intussusception because of a significantly higher coexistence of malignancy.
  • [MeSH-major] Intussusception / diagnosis. Intussusception / surgery

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  • (PMID = 19399931.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
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  • [Other-IDs] NLM/ PMC2675089
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64. Palka-Hamblin HL, Gierut JJ, Bie W, Brauer PM, Zheng Y, Asara JM, Tyner AL: Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6. J Cell Sci; 2010 Jan 15;123(Pt 2):236-45
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  • Disruption of the gene encoding protein tyrosine kinase 6 (PTK6) leads to increased growth, impaired enterocyte differentiation and higher levels of nuclear beta-catenin in the mouse small intestine.
  • In the SW620 colorectal adenocarcinoma cell line, nuclear-targeted PTK6 negatively regulates endogenous beta-catenin/TCF transcriptional activity, whereas membrane-targeted PTK6 enhances beta-catenin/TCF regulated transcription.

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  • (PMID = 20026641.001).
  • [ISSN] 1477-9137
  • [Journal-full-title] Journal of cell science
  • [ISO-abbreviation] J. Cell. Sci.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK044525-15; United States / NIDDK NIH HHS / DK / DK44525; United States / NIDDK NIH HHS / DK / T32 DK007739; United States / NIDDK NIH HHS / DK / T32 DK07739; United States / NIDDK NIH HHS / DK / R01 DK068503-05; United States / NIDDK NIH HHS / DK / R01 DK068503; United States / NIDDK NIH HHS / DK / DK068503-05; United States / NIDDK NIH HHS / DK / R01 DK044525; United States / NIDDK NIH HHS / DK / DK044525-15; United States / NIDDK NIH HHS / DK / DK068503
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / TCF Transcription Factors; 0 / beta Catenin; 21820-51-9 / Phosphotyrosine; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / PTK6 protein, human; EC 2.7.10.2 / Ptk6 protein, mouse; EC 2.7.10.2 / src-Family Kinases
  • [Other-IDs] NLM/ PMC2954247
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65. Chaïbi C, Cotte-Laffitte J, Sandré C, Esclatine A, Servin AL, Quéro AM, Géniteau-Legendre M: Rotavirus induces apoptosis in fully differentiated human intestinal Caco-2 cells. Virology; 2005 Feb 20;332(2):480-90
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  • [Title] Rotavirus induces apoptosis in fully differentiated human intestinal Caco-2 cells.
  • Rotaviruses, which are the main cause of viral gastroenteritis in young children, induce structural and functional damages in infected mature enterocytes of the small intestine.
  • To investigate a relationship between rotavirus infection and cell death by apoptosis, we used the human intestinal Caco-2 cell line.
  • [MeSH-minor] Adenocarcinoma. Annexin A5 / metabolism. Cell Differentiation. Cell Line, Tumor. Colonic Neoplasms. Cytochromes c / analysis. Flow Cytometry. Humans. In Situ Nick-End Labeling. Membrane Potentials / physiology. Mitochondria / physiology

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  • (PMID = 15680413.001).
  • [ISSN] 0042-6822
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Annexin A5; 9007-43-6 / Cytochromes c
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66. Overman MJ: Recent advances in the management of adenocarcinoma of the small intestine. Gastrointest Cancer Res; 2009 May;3(3):90-6
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  • [Title] Recent advances in the management of adenocarcinoma of the small intestine.
  • Adenocarcinoma of the small intestine is a rare malignancy with limited data available to guide therapeutic decisions.
  • Delays in diagnosis are frequent and the majority of patients will present with advanced-stage disease and either lymph node involvement or distant metastatic disease.
  • Recent retrospective and prospective studies have helped to clarify the optimal chemotherapy approach for advanced small bowel adenocarcinoma.
  • This article reviews the clinical features and evaluation of patients with small bowel adenocarcinoma and focuses on recent advances in management.

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  • (PMID = 19626152.001).
  • [ISSN] 1934-7820
  • [Journal-full-title] Gastrointestinal cancer research : GCR
  • [ISO-abbreviation] Gastrointest Cancer Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2713134
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67. Niwa Y, Nakamura M, Omiya N, Itoh A, Hirooka Y, Goto H: Ileal cancer and erosions in the small intestine revealed by capsule endoscopy. Endoscopy; 2007 Feb;39 Suppl 1:E7-8
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  • [Title] Ileal cancer and erosions in the small intestine revealed by capsule endoscopy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Capsule Endoscopy. Colonic Neoplasms / diagnosis. Endoscopy, Gastrointestinal. Enteritis / diagnosis. Gastrointestinal Hemorrhage / diagnosis. Ileal Neoplasms / diagnosis. Intestinal Polyps / diagnosis. Neoplasms, Multiple Primary / diagnosis

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  • (PMID = 17285495.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Quinolones; 111911-87-6 / rebamipide; OF5P57N2ZX / Alanine
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68. Schwartz GD, Barkin JS: Small-bowel tumors detected by wireless capsule endoscopy. Dig Dis Sci; 2007 Apr;52(4):1026-30
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  • [Title] Small-bowel tumors detected by wireless capsule endoscopy.
  • Small bowel tumors are difficult to diagnose because of their endoscopic inaccessibility.
  • The purpose of this report is to describe the largest series of patients with small bowel tumors detected by capsule endoscopy.
  • Eighty six patients were derived from the Given Imaging clinical database on a survey of Pillcam SB capsule users who were diagnosed with 87 small bowel tumors, 1 cecal tumor, and 1 gastric tumor.
  • Of the 87 reported small bowel tumors, 4 were identified in the duodenum, 43 tumors were identified in the jejunum, 18 tumors were identified in the ileum, and 22 tumors were located in the mid to distal small bowel.
  • The most common malignant tumors were adenocarcinoma, carcinoids, melanomas, lymphomas, and sarcomas.
  • Capsule endoscopy is the diagnostic procedure of choice in patients with suspected small bowel tumors.
  • [MeSH-major] Capsule Endoscopy. Endoscopy, Gastrointestinal. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 17380403.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Gupta C, Malani AK, Rangineni S: Breast metastasis of ilial carcinoid tumor: case report and literature review. World J Surg Oncol; 2006;4:15
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  • CASE PRESENTATION: We report a case of unilateral breast metastasis from carcinoid tumor of the small intestine in a 52-year-old woman who was successfully treated by lumpectomy and radiation therapy.
  • An extensive review of the literature reveals only a few cases of metastatic carcinoid to the breast from small intestinal primaries.
  • Their histological appearance may mimic ductal adenocarcinoma of the breast.

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  • (PMID = 16566835.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1481627
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70. Wang C, Zhou XG: [Role of CDX2 immunostaining in diagnosis of gastrointestinal adenocarcinoma]. Zhonghua Bing Li Xue Za Zhi; 2006 Apr;35(4):228-31
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  • [Title] [Role of CDX2 immunostaining in diagnosis of gastrointestinal adenocarcinoma].
  • OBJECTIVE: To study the expression of CDX2 in normal and tumor tissues, and to evaluate the value of CDX2 immunostaining in the diagnosis of gastrointestinal adenocarcinoma.
  • RESULTS: CDX2 was strongly expressed in surface epithelium of 13 samples of normal intestine and in ductal epithelium of 8 samples of normal pancreas, as well as in 47 samples (92.2%) of colonic adenocarcinoma and 58 samples (66.9%) of gastric adenocarcinoma.
  • The positivity rates were as follows: ovarian mucinous adenocarcinoma 15.6% (10/64), pancreatic cancer 33.3% (3/9), thyroid cancer 27.3% (3/11) and extrahepatic biliary cancer 25% (4/16).
  • CONCLUSIONS: CDX2 is expressed mainly in normal epithelium of intestinal tract and small pancreatic ducts, as well as in primary adenocarcinoma of gastrointestinal tract.
  • CDX2 may thus play an important role in distinguishing primary non-intestinal adenocarcinoma from metastatic adenocarcinoma of gastric or colorectal primary.
  • [MeSH-major] Adenocarcinoma / diagnosis. Gastrointestinal Neoplasms / diagnosis. Homeodomain Proteins / metabolism
  • [MeSH-minor] Colonic Neoplasms / diagnosis. Colonic Neoplasms / metabolism. Female. Gastrointestinal Tract / chemistry. Gastrointestinal Tract / pathology. Humans. Immunohistochemistry. Male. Stomach Neoplasms / diagnosis. Stomach Neoplasms / metabolism. Tissue Array Analysis

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  • (PMID = 16776981.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins
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71. Namikawa T, Hanazaki K: Clinical analysis of primary anaplastic carcinoma of the small intestine. World J Gastroenterol; 2009 Feb 7;15(5):526-30
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  • [Title] Clinical analysis of primary anaplastic carcinoma of the small intestine.
  • Primary anaplastic carcinoma is a rare variant of small intestinal cancer.
  • Most reports of primary anaplastic carcinoma of the small intestine are isolated case reports, therefore the clinicopathological features, therapeutic management, and surgical outcome of this tumor type remain unclear.
  • This review analyzes the available clinical characteristics of primary anaplastic carcinoma of the small intestine and investigates key differences from differentiated adenocarcinoma of the small intestine.
  • A Medline search was performed using the keywords 'small intestine' and 'anaplastic carcinoma' or 'undifferentiated carcinoma'.
  • The literature revealed a poor prognosis for patients who underwent surgical resection for anaplastic carcinoma of the small intestine, which gave a 3-year overall survival rate of 10.8% and a median survival time of 5.0 mo.
  • The literature suggests that anaplastic carcinoma is markedly more aggressive than differentiated adenocarcinoma of the small intestine.
  • Surgical resection with the aim of complete tumor removal provides the only beneficial therapeutic option for patients with anaplastic carcinoma of the small intestine, because chemotherapy and radiation therapy have no significant effect on the rate of survival.
  • However, despite complete tumor resection, most patients with anaplastic carcinoma of the small intestine are at great risk of disease recurrence.
  • This report also highlights the importance of a systematic diagnostic approach for anaplastic carcinoma of the small intestine.
  • [MeSH-major] Carcinoma / pathology. Intestinal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intestinal Mucosa / pathology. Intestine, Small / pathology. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis. Survivors

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  • (PMID = 19195053.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2653339
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72. McCoy AM, Hackett ES, Callan RJ, Powers BE: Alimentary-associated carcinomas in five Vietnamese potbellied pigs. J Am Vet Med Assoc; 2009 Dec 1;235(11):1336-41
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  • Radiography revealed distended loops of small intestine in 2 pigs.
  • Types of tumor included cholangiocellular carcinoma, transmural gastric carcinoma, small intestinal adenocarcinoma, metastatic hepatocellular carcinoma, and carcinoma.
  • The tumors involved the stomach, small intestine, spiral colon, liver, and gall bladder.

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  • (PMID = 19951106.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Guimarães GC, Terabe F, Rossi BM, Aguiar Júnior S, Ferreira Fde O, Nakagawa WT, Lopes A: The double-barreled wet ileostomy: an alternative method for simultaneous urinary and intestinal diversion without intestinal anastomosis after total colectomy and pelvic exenteration. Int J Colorectal Dis; 2005 Mar;20(2):190-3
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  • [Title] The double-barreled wet ileostomy: an alternative method for simultaneous urinary and intestinal diversion without intestinal anastomosis after total colectomy and pelvic exenteration.
  • [MeSH-major] Adenocarcinoma / therapy. Colectomy / methods. Colonic Neoplasms / therapy. Ileostomy. Intestine, Small / surgery. Urinary Diversion / methods
  • [MeSH-minor] Anastomosis, Roux-en-Y. Colonoscopy. Follow-Up Studies. Humans. Male. Middle Aged. Prostatectomy. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / secondary. Prostatic Neoplasms / surgery. Radiotherapy, Adjuvant. Reoperation. Tomography, X-Ray Computed

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  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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74. Hétet JF, Rigaud J, Müller B, Léauté F, Renaudin K, Bouchot O, Karam G: [Unusual metastatic spread after converted laparoscopic radical nephrectomy: natural history of the tumour or role of laparoscopy?]. Prog Urol; 2005 Sep;15(4):718-21
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  • [Transliterated title] Evolution métastatique inhabituelle apres néphrectomie elargie par lomboscopie convertie: histoire naturelle de la tumeur ou responsabilité de la coelioscopie?
  • The authors report a case of metastasis to unusual sites (sigmoid colon, small intestine, root of the nose) after converted retroperitoneal laparoscopic radical nephrectomy for a T3 renal tumour, which raises the problem of the possible role of the laparoscopic approach in this unusual metastatic progression of the disease.
  • [MeSH-major] Adenocarcinoma / secondary. Kidney Neoplasms / pathology. Laparoscopy / adverse effects. Neoplasm Seeding. Nephrectomy / methods

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  • (PMID = 16459693.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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75. Turan M, Karadayi K, Duman M, Ozer H, Arici S, Yildirir C, Koçak O, Sen M: Small bowel tumors in emergency surgery. Ulus Travma Acil Cerrahi Derg; 2010 Jul;16(4):327-33
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  • [Title] Small bowel tumors in emergency surgery.
  • BACKGROUND: The aim of the present study was to describe the clinical presentation, diagnostic work-up, surgical therapy, and prognosis of 13 patients with small bowel tumor admitted for surgical procedures in an emergency setting.
  • METHODS: From 1996 to 2008, 13 consecutive surgical cases of small bowel tumors were treated at the Cumhuriyet University Faculty of Medicine, Department of General Surgery, and Kütahya State Hospital, Department of General Surgery.
  • RESULTS: Intestinal obstruction (7 cases) and perforation (5 cases) were the most common clinical presentations, followed by intussusception (1 case).
  • Adenocarcinoma was the most frequent histologic type (4 cases), while small bowel sarcoma was seen in three cases and non-Hodgkin lymphoma in two cases.
  • The remaining cases had carcinoid tumor, small bowel angioleiomyoma, Brunner's gland adenoma, and inflammatory pseudotumor of the small intestine.
  • CONCLUSION: Small bowel tumors are rare, the symptoms often non-specific, and the accuracy of different diagnostic tests remains to be improved.
  • [MeSH-major] Adenocarcinoma / surgery. Emergencies. Intestinal Neoplasms / surgery. Surgical Procedures, Operative / methods
  • [MeSH-minor] Angiomyoma / surgery. Hemangiosarcoma / surgery. Humans. Intestinal Obstruction / etiology. Intestinal Perforation / etiology. Leiomyosarcoma / surgery. Retrospective Studies

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  • (PMID = 20849049.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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76. Catena F, Ansaloni L, Gazzotti F, Gagliardi S, Di Saverio S, De Cataldis A, Taffurelli M: Small bowel tumours in emergency surgery: specificity of clinical presentation. ANZ J Surg; 2005 Nov;75(11):997-9
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  • [Title] Small bowel tumours in emergency surgery: specificity of clinical presentation.
  • BACKGROUND: Despite advances in diagnostic modalities, small bowel tumours are notoriously difficult to diagnose and are often advanced at the time of definitive treatment.
  • The aim of the present study was to describe the clinical presentation, diagnostic work-up, surgical therapy and short-term outcome of 34 patients with primary and secondary small bowel tumours submitted for surgical procedures in an emergency setting and to look for a correlation between clinical presentation and the type of tumours.
  • METHODS: From 1995 to 2005, 34 consecutive surgical cases of small bowel tumours were treated at the Department of Emergency Surgery of St Orsola-Malpighi University Hospital, Bologna, Italy.
  • RESULTS: All patients presented as surgical emergencies: intestinal obstruction was the most common clinical presentation (15 cases), followed by perforation (11 cases) and gastrointestinal bleeding (eight cases).
  • Lymphoma was the most frequent histologic type (nine patients), followed by stromal tumours (eight patients), carcinoids (seven patients), adenocarcinoma (seven patients) and metastasis (three patients).
  • Of the nine patients with lymphoma, eight were perforated, all patients with stromal tumours had bleeding, and all carcinoids patients had bowel obstruction.
  • There were two patients with melanoma metastasis, both had bowel intussusception.
  • CONCLUSIONS: The present study shows that there is a correlation between small bowel tumours and clinical emergency presentation: gastrointestinal stromal tumours (GIST) mostly bleed; carcinoids make an obstruction; lymphomas cause a perforation; and melanoma metastasis causes intussusception.
  • [MeSH-major] Intestinal Neoplasms / complications
  • [MeSH-minor] Adenocarcinoma / complications. Adult. Aged. Aged, 80 and over. Carcinoid Tumor / complications. Emergency Service, Hospital. Female. Gastrointestinal Hemorrhage / etiology. Gastrointestinal Stromal Tumors / complications. Humans. Intestinal Obstruction / etiology. Intestinal Obstruction / surgery. Intestinal Perforation / etiology. Intestinal Perforation / surgery. Intestine, Small. Intussusception / etiology. Lymphoma / complications. Male. Melanoma / complications. Middle Aged. Neoplasm Metastasis. Retrospective Studies

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  • (PMID = 16336396.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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77. Sheikh SS, Al-Khatti AA, Amr SS: Metachronus malignant rhabdoid tumor of the ileum and adenocarcinoma of lung: a unique case report. Ann Diagn Pathol; 2008 Feb;12(1):57-61
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  • [Title] Metachronus malignant rhabdoid tumor of the ileum and adenocarcinoma of lung: a unique case report.
  • Carcinomas of small intestine are quite uncommon neoplasms, and those with rhabdoid differentiation are exceedingly rare.
  • These poorly differentiated tumors pose a great deal of difficulty in diagnosis as well as in deciding whether they are primary or metastatic in origin because malignant rhabdoid tumors or carcinomas with rhabdoid differentiation of other sites can metastasize to the small intestine.
  • They behave more aggressively than the typical adenocarcinomas of the same location.
  • Herein, we report a 52-year-old patient with primary small bowel malignant rhabdoid tumor, who was completely disease-free after the initial presentation and management.
  • Five years later, he was found to have a lung mass proved to be adenocarcinoma, exhibiting focal giant cell differentiation without rhabdoid features.
  • [MeSH-major] Adenocarcinoma / pathology. Ileal Neoplasms / pathology. Lung Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Rhabdoid Tumor / pathology

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  • (PMID = 18164418.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Shenderey RL, Thompson N, Mansfield JC, Rees C: Adenocarcinoma as a complication of small bowel Crohn's disease. Eur J Gastroenterol Hepatol; 2005 Nov;17(11):1255-7
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  • [Title] Adenocarcinoma as a complication of small bowel Crohn's disease.
  • Carcinoma is a recognized but rare complication of small bowel Crohn's disease.
  • This case series emphasizes the importance of considering this diagnosis in patients with small bowel Crohn's disease.
  • We report three cases in which patients were treated for presumed exacerbations of Crohn's, but were subsequently found to have underlying small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Crohn Disease / complications. Ileal Neoplasms / etiology. Jejunal Neoplasms / etiology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Intestinal Obstruction / etiology. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16215441.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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79. Xie J, Itzkowitz SH: Cancer in inflammatory bowel disease. World J Gastroenterol; 2008 Jan 21;14(3):378-89
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  • [Title] Cancer in inflammatory bowel disease.
  • Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC).
  • Colon cancer risk in inflammatory bowel disease increases with longer duration of colitis, greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of the bowel.
  • Patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.
  • Other extra intestinal cancers, such as hepatobiliary and hematopoietic cancer, have shown variable incidence rates.
  • [MeSH-major] Colorectal Neoplasms / physiopathology. Inflammatory Bowel Diseases / physiopathology. Neoplasms / physiopathology

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  • (PMID = 18200660.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 118
  • [Other-IDs] NLM/ PMC2679126
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80. Czaykowski P, Hui D: Chemotherapy in small bowel adenocarcinoma: 10-year experience of the British Columbia Cancer Agency. Clin Oncol (R Coll Radiol); 2007 Mar;19(2):143-9
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  • [Title] Chemotherapy in small bowel adenocarcinoma: 10-year experience of the British Columbia Cancer Agency.
  • AIMS: Small bowel adenocarcinoma (SBA) is a rare, frequently lethal, malignancy.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestine, Small / drug effects

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  • (PMID = 17355111.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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81. Malamut G, Cellier C: [Celiac disease]. Rev Med Interne; 2010 Jun;31(6):428-33
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  • Diagnosis relies on the evidence of histological villous atrophy in proximal small bowel and the presence of specific serum antibodies.
  • Gluten free diet allows prevention of malignant complications such as small bowel adenocarcinoma and lymphoma, and osteopenia.
  • If not the case, serious complications of celiac disease, such as clonal refractory celiac sprue and intestinal T-cell lymphoma should be suspected.

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  • [Copyright] Copyright 2010 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.
  • (PMID = 20359791.001).
  • [ISSN] 1768-3122
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers; 0 / HLA-DQ Antigens; 0 / HLA-DQ2 antigen; 0 / HLA-DQ8 antigen
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82. Blanco LP, Dirita VJ: Antibodies enhance interaction of Vibrio cholerae with intestinal M-like cells. Infect Immun; 2006 Dec;74(12):6957-64
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  • [Title] Antibodies enhance interaction of Vibrio cholerae with intestinal M-like cells.
  • Intestinal M cells bear a receptor for secretory immunoglobulin A (IgA) (sIgA) facing the lumen of the epithelial surfaces.
  • Cells bearing this receptor are also found throughout an experimental monolayer consisting of polarized Caco-2 cells, a colon adenocarcinoma cell line.
  • The presence of antibodies (mainly sIgA) in the lumen of the small intestine led us to explore the participation of the sIgA receptor and antibodies in the interaction of Caco-2-associated M-like cells with the mucosal pathogen Vibrio cholerae.
  • Our results indicate that in this in vitro model system of intestinal epithelia, human sIgA and IgG contribute to the uptake of V. cholerae by M-like cells, probably through an interaction with GM(1).

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  • (PMID = 17000721.001).
  • [ISSN] 0019-9567
  • [Journal-full-title] Infection and immunity
  • [ISO-abbreviation] Infect. Immun.
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / R01 AG041525; United States / NIAID NIH HHS / AI / R01 AI 31645; United States / NIAID NIH HHS / AI / R01 AI 41525
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / IgA receptor; 0 / Immunoglobulin A, Secretory; 0 / Immunoglobulin G; 0 / Receptors, Cell Surface; 0 / Receptors, Fc; 0 / choleragen receptor; 37758-47-7 / G(M1) Ganglioside; 9012-63-9 / Cholera Toxin
  • [Other-IDs] NLM/ PMC1698086
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83. Park ET, Oh HK, Gum JR Jr, Crawley SC, Kakar S, Engel J, Leow CC, Gao WQ, Kim YS: HATH1 expression in mucinous cancers of the colorectum and related lesions. Clin Cancer Res; 2006 Sep 15;12(18):5403-10
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  • PURPOSE: Mucinous cancers and signet ring carcinomas are distinct classes of colon cancers characterized by their production of copious quantities of intestinal goblet cell mucin, MUC2.
  • Deletion of transcription factor HATH1 ablates the biogenesis of goblet cells in developing mouse intestine, and forced expression of HATH1 results in elevated expression of MUC2 in colon cancer cells.
  • EXPERIMENTAL DESIGN: Immunohistochemistry and confocal microscopy was used to examine HATH1 expression and subcellular distribution in normal colon and small intestine, mucinous cancers, signet ring carcinomas, and nonmucinous cancers and in precursor lesions, including hyperplastic polyps, serrated adenomas, tubular adenomas, and villous adenomas.
  • In the small intestine, only cytoplasmic expression of HATH1 in enteroendocrine cells was detected.
  • CONCLUSIONS: This study confirms the importance of HATH1 for the development of intestinal secretory cells.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Basic Helix-Loop-Helix Transcription Factors / metabolism. Colorectal Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Humans. Intestinal Polyps / pathology. Intestines / cytology. Intestines / ultrastructure. Male. Microscopy, Fluorescence. Middle Aged. Mucin-2. Mucins / metabolism. Promoter Regions, Genetic. Tissue Distribution. Transcriptional Activation

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  • (PMID = 17000673.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATOH1 protein, human; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / MUC2 protein, human; 0 / Muc2 protein, mouse; 0 / Mucin-2; 0 / Mucins
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84. Schottenfeld D, Beebe-Dimmer JL, Vigneau FD: The epidemiology and pathogenesis of neoplasia in the small intestine. Ann Epidemiol; 2009 Jan;19(1):58-69
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  • [Title] The epidemiology and pathogenesis of neoplasia in the small intestine.
  • PURPOSE: The mucosa of the small intestine encompasses about 90% of the luminal surface area of the digestive system, but only 2% of the total annual gastrointestinal cancer incidence in the United States.
  • METHODS: The remarkable contrast in age-standardized cancer incidence between the small and large intestine has been reviewed with respect to the cell type patterns, demographic features, and molecular characteristics of neoplasms.
  • RESULTS: Particularly noteworthy is the predominance of adenocarcinoma in the colon, which exceeds 98% of the total incidence by cell type, in contrast to that of 30% to 40% in the small intestine, resulting in an age-standardized ratio of rates exceeding 50-fold.
  • The positive correlation in global incidence rates of small and large intestinal neoplasms and the reciprocal increases in risk of second primary adenocarcinomas suggest that there are common environmental risk factors.
  • The pathophysiology of Crohn inflammatory bowel disease and the elevated risk of adenocarcinoma demonstrate the significance of the impaired integrity of the mucosal barrier and of aberrant immune responses to luminal indigenous and potentially pathogenic microorganisms.
  • CONCLUSION: In advancing a putative mechanism for the contrasting mucosal susceptibilities of the small and large intestine, substantial differences are underscored in the diverse taxonomy, concentration and metabolic activity of anaerobic organisms, rate of intestinal transit, changing pH, and the enterohepatic recycling and metabolism of bile acids.

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  • (PMID = 19064190.001).
  • [ISSN] 1873-2585
  • [Journal-full-title] Annals of epidemiology
  • [ISO-abbreviation] Ann Epidemiol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / K07 CA127214; United States / NCI NIH HHS / CA / N01PC35145; United States / NCI NIH HHS / CA / 1K07CA127214-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines
  • [Number-of-references] 151
  • [Other-IDs] NLM/ NIHMS521424; NLM/ PMC3792582
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85. Garrido A, Luque A, Vázquez A, Hernández JM, Alcántara F, Márquez JL: [Primary small bowel neoplasms as a complication of celiac disease]. Gastroenterol Hepatol; 2009 Nov;32(9):618-21
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  • [Title] [Primary small bowel neoplasms as a complication of celiac disease].
  • [Transliterated title] Neoplasias primarias de intestino delgado como complicación de la enfermedad celíaca.
  • The most serious complication in these patients is the development of neoplasms, the most frequent being enteropathy-associated T-cell lymphoma; however, an increase in the incidence of small bowel adenocarcinoma has also been described.
  • We present two cases of small bowel carcinoma in patients with celiac disease, which were diagnosed at the onset of the disease.
  • [MeSH-major] Adenocarcinoma / etiology. Celiac Disease / complications. Duodenal Neoplasms / etiology. Ileal Neoplasms / etiology

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  • (PMID = 19625106.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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86. Zhang MQ, Lin F, Hui P, Chen ZM, Ritter JH, Wang HL: Expression of mucins, SIMA, villin, and CDX2 in small-intestinal adenocarcinoma. Am J Clin Pathol; 2007 Nov;128(5):808-16
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  • [Title] Expression of mucins, SIMA, villin, and CDX2 in small-intestinal adenocarcinoma.
  • Expression of gastrointestinal biomarkers MUC1, MUC2, MUC5AC, small-intestinal mucin antigen (SIMA), villin, and CDX2 has been studied in colorectal adenocarcinoma (CRC).
  • Little is known, however, about their expression in small-intestinal adenocarcinoma (SIA).
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Intestinal Neoplasms / metabolism. Intestine, Small / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 17951204.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Microfilament Proteins; 0 / Mucins; 0 / Neoplasm Proteins; 0 / gastro-intestinal mucus-associated antigens; 0 / villin
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87. Brücher BL, Geddert H, Langner C, Höfler H, Fink U, Siewert JR, Sarbia M: Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel. Int J Cancer; 2006 Sep 15;119(6):1298-302
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  • [Title] Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel.
  • Small bowel adenocarcinoma (SB-AC) is a very rare tumor entity.
  • Paraffin-embedded tumor samples from 56 patients with SB-AC who underwent surgical resection between January 1985 and December 2003 were investigated for hypermethylation by means of methylation-specific real-time PCR, and compared with our findings in a previously investigated series of 50 gastric adenocarcinomas.
  • In comparison with adenocarcinomas of the stomach, SB-AC revealed a significantly higher rate of hypermethylation of HPP1 (86% versus 54%, p = 0.0003), p16(INK4A) (32% versus 10%, p = 0.0006), and a significantly lower rate of hypermethylation of APC (48% versus 84%, p = 0.0001).
  • Our findings suggest that hypermethylation of hMLH1, HPP1, p16(INK4A) and APC is frequent in primary adenocarcinomas of the small bowel.
  • The differences in the hypermethylation spectrum of small bowel and stomach cancer indicate significant epigenetic differences between these tumors.
  • [MeSH-major] Adenocarcinoma / genetics. DNA Methylation. Intestinal Neoplasms / genetics. Intestine, Small / pathology. Neoplasm Proteins / genetics

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  • (PMID = 16619216.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Carrier Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / TMEFF2 protein, human; 0 / Tumor Suppressor Protein p14ARF
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88. Overman MJ, Pozadzides J, Kopetz S, Wen S, Abbruzzese JL, Wolff RA, Wang H: Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. Br J Cancer; 2010 Jan 5;102(1):144-50
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  • [Title] Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine.
  • BACKGROUND: Despite having a dramatically larger surface area than the large intestine, the small intestine is an infrequent site for the development of adenocarcinoma.
  • To better understand the molecular abnormalities in small bowel adenocarcinoma (SBA), we characterised a number of candidate oncogenic pathways and the immunophenotype of this rare cancer.
  • CONCLUSIONS: These results suggest that alterations in DNA MMR pathways are common in SBAs, similar to what is observed in large bowel adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / genetics. Duodenal Neoplasms / genetics. Gene Expression Profiling. Immunophenotyping. Neoplasm Proteins / biosynthesis. Oncogenes

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  • (PMID = 19935793.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ PMC2813754
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89. Xiao F, Crissey MA, Lynch JP, Kaestner KH, Silberg DG, Suh E: Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice. Cancer Biol Ther; 2005 Jun;4(6):669-75
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  • [Title] Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice.
  • Intestinal metaplasia of the gastric mucosa is an important component in the pathway to adenocarcinoma.
  • The mechanisms that induce the progression from intestinal metaplasia to cancer have not been elucidated.
  • Therefore, we investigated the role of high salt diet on gastric epithelial cell proliferation and differentiation, using our mouse model that ectopically expressed Cdx2 homeodomain transcription factor and induced an intestinal metaplastic phenotype in the gastric epithelia.
  • Taken together, these data implicate that intestinal metaplasia in concert with a high-salt diet induces epithelial proliferation, apoptosis, and alters cellular types in the gastric mucosa of mice.
  • [MeSH-major] Gastric Mucosa / pathology. Intestine, Small / pathology. Sodium Chloride, Dietary / administration & dosage

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  • (PMID = 15970710.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P30-DK-50306; United States / NIDDK NIH HHS / DK / R01-DK46704; United States / NIDDK NIH HHS / DK / R01-DK59539
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdx2 protein, mouse; 0 / Homeodomain Proteins; 0 / Sodium Chloride, Dietary; 0 / Transcription Factors
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90. Lakatos PL, Horvath HC, Zubek L, Pak G, Pak P, Fuszek P, Nagypal A, Papp J: Double-balloon endoscopy for small intestinal disease: a single-center experience in Hungary. Med Sci Monit; 2010 Mar;16(3):MT22-27
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  • [Title] Double-balloon endoscopy for small intestinal disease: a single-center experience in Hungary.
  • RESULTS: In OGIB, abnormal small-bowel findings were noted in 50 patients (60.2%) including angiodysplasias, erosions, and small ulcers.
  • In polyposis/suspected malignancy, polyps were removed by snare polypectomy in 8 Peutz-Jeghers patients, while primary adenocarcinoma was diagnosed in 4.
  • CONCLUSIONS: Based on our experience, DBE is a safe and useful method for evaluating and treating small-bowel disease in selected patients with obscure bleeding, IBD or polyposis syndromes.
  • [MeSH-major] Catheterization / methods. Endoscopy / methods. Intestinal Diseases / diagnosis. Intestine, Small / pathology

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  • (PMID = 20190694.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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91. Cross AJ, Leitzmann MF, Subar AF, Thompson FE, Hollenbeck AR, Schatzkin A: A prospective study of meat and fat intake in relation to small intestinal cancer. Cancer Res; 2008 Nov 15;68(22):9274-9
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  • [Title] A prospective study of meat and fat intake in relation to small intestinal cancer.
  • Diets high in red and processed meats are associated with carcinogenesis of the large intestine, but no prospective study has examined meat and fat intake in relation to cancer of the small intestine.
  • We prospectively investigated meat and fat intakes, estimated from a food frequency questionnaire, in relation to small intestinal cancer among half a million men and women enrolled in the NIH-AARP Diet and Health Study.
  • During up to 8 years of follow-up, 60 adenocarcinomas and 80 carcinoid tumors of the small intestine were diagnosed.
  • Despite slightly elevated HRs for red meat, there were no clear associations for red or processed meat intake and either adenocarcinoma or carcinoid tumors of the small intestine.
  • In contrast, we noted a markedly elevated risk for carcinoid tumors of the small intestine with saturated fat intake in both the categorical (highest versus lowest tertile: HR, 3.18; 95% CI, 1.62-6.25) and continuous data (HR, 3.72; 95% CI, 1.79-7.74 for each 10-g increase in intake per 1,000 kcal).
  • [MeSH-major] Dietary Fats / administration & dosage. Intestinal Neoplasms / etiology. Intestine, Small. Meat
  • [MeSH-minor] Adenocarcinoma / etiology. Aged. Carcinoid Tumor / etiology. Female. Humans. Male. Middle Aged. Proportional Hazards Models. Prospective Studies

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  • (PMID = 19010900.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CA999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Fats
  • [Other-IDs] NLM/ NIHMS70557; NLM/ PMC2597051
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92. Dasari BV, Lee J, Reid D, Carey D: Ileocecal intussusception due to isolated metastasis from primary esophageal adenocarcinoma. South Med J; 2009 Apr;102(4):419-21
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  • [Title] Ileocecal intussusception due to isolated metastasis from primary esophageal adenocarcinoma.
  • Isolated metastases to the small intestine are rare, but are known to originate from malignant melanoma, or breast or lung cancer.
  • To our knowledge, this is the first reported case of metastases from primary esophageal adenocarcinoma presenting as subacute small bowel obstruction due to ileocecal intussusception.
  • Physicians should consider palliative resection and anastomosis or a bypass procedure in patients with intestinal obstruction.
  • [MeSH-major] Adenocarcinoma / secondary. Cecal Neoplasms / etiology. Esophageal Neoplasms / pathology. Ileal Neoplasms / secondary. Intussusception / etiology
  • [MeSH-minor] Adult. Colonoscopy. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19279517.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Trikudanathan G, Dasanu CA: Evolving pharmacotherapeutic strategies for small bowel adenocarcinoma. Expert Opin Pharmacother; 2010 Jul;11(10):1695-704
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  • [Title] Evolving pharmacotherapeutic strategies for small bowel adenocarcinoma.
  • IMPORTANCE OF THE FIELD: Owing to nonspecific signs and symptoms, the majority of patients with small bowel adenocarcinoma (SBA) present with advanced-stage disease.
  • [MeSH-major] Adenocarcinoma / drug therapy. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology

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  • (PMID = 20446863.001).
  • [ISSN] 1744-7666
  • [Journal-full-title] Expert opinion on pharmacotherapy
  • [ISO-abbreviation] Expert Opin Pharmacother
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
  • [Number-of-references] 48
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94. Policarpio-Nicolas ML, Nicolas MM, Keh P, Laskin WB: Postradiation angiosarcoma of the small intestine: a case report and review of literature. Ann Diagn Pathol; 2006 Oct;10(5):301-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postradiation angiosarcoma of the small intestine: a case report and review of literature.
  • Postradiation angiosarcoma arising in the small intestine is rare with only 11 cases documented in the English-language literature.
  • Herein, we report a postradiation angiosarcoma of the small intestine 9 years after radiotherapy for uterine cervical adenocarcinoma.
  • The patient presented with symptoms of intestinal obstruction.
  • At exploratory laparotomy, tumor nodules involved the small bowel.
  • The diagnosis of angiosarcoma was confirmed immunohistochemically by tumor cell expression of CD31, CD34, and factor VIII-related antigen.
  • The diagnosis of PRA should be entertained for any poorly differentiated neoplasm arising in a previously irradiated site.
  • The correct diagnosis of PRA depends upon histomorphologic identification of vascular differentiation, coupled with immunohistochemical expression of endothelial-related markers.
  • [MeSH-major] Hemangiosarcoma / etiology. Intestinal Neoplasms / etiology. Intestine, Small. Neoplasms, Radiation-Induced / diagnosis
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Antigens, CD31 / metabolism. Antigens, CD34 / metabolism. Cell Transformation, Neoplastic / pathology. Factor VIII / metabolism. Fatal Outcome. Female. Gene Expression Regulation, Neoplastic. Humans. Intestinal Obstruction / etiology. Middle Aged. Prognosis. Uterine Cervical Neoplasms / radiotherapy

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  • (PMID = 16979525.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 9001-27-8 / Factor VIII
  • [Number-of-references] 17
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95. Krishnamurthy P, Varghese SE, Gopalswamy N, Hillman N, Ali SA: Small-bowel adenocarcinoma: case report and review of literature on diagnosis of small-bowel tumors. Gastroenterol Hepatol (N Y); 2007 Feb;3(2):129-35
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  • [Title] Small-bowel adenocarcinoma: case report and review of literature on diagnosis of small-bowel tumors.

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  • (PMID = 21960822.001).
  • [ISSN] 1554-7914
  • [Journal-full-title] Gastroenterology & hepatology
  • [ISO-abbreviation] Gastroenterol Hepatol (N Y)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3099353
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96. Overman MJ, Varadhachary GR, Kopetz S, Adinin R, Lin E, Morris JS, Eng C, Abbruzzese JL, Wolff RA: Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater. J Clin Oncol; 2009 Jun 1;27(16):2598-603
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
  • PURPOSE: Adenocarcinomas of the small bowel and ampulla of Vater represent rare cancers that have limited data regarding first-line therapy.
  • We conducted a phase II trial to evaluate the benefit of capecitabine in combination with oxaliplatin (CAPOX) in patients with advanced adenocarcinoma of small bowel or ampullary origin.
  • CAPOX should be considered a new standard regimen for advanced small bowel and ampullary adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / drug therapy. Ampulla of Vater / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Common Bile Duct Neoplasms / drug therapy. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology

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  • (PMID = 19164203.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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97. Chua TC, Koh JL, Yan TD, Liauw W, Morris DL: Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. J Surg Oncol; 2009 Aug 1;100(2):139-43
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  • [Title] Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma.
  • BACKGROUND: Small bowel adenocarcinoma is a rare malignancy that presents both a diagnostic and therapeutic challenge.
  • We review our experience with small bowel peritoneal carcinomatosis following treatment with cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC).
  • METHODS: From a prospective database of CRS and PIC, seven patients were identified to have undergone treatment for small bowel peritoneal carcinomatosis with CRS and hyperthermic intraperitoneal chemotherapy (Mitomycin C) and early postoperative intraperitoneal chemotherapy (5FU).
  • Tumor histology of poorly differentiated adenocarcinoma with signet ring, lymphovascular invasion and perineural invasion appeared to be associated with a poor outcome.
  • CONCLUSION: Cytoreductive surgery and perioperative intraperitoneal chemotherapy is a treatment option for small bowel cancer peritoneal carcinomatosis with encouraging survival results.
  • [MeSH-major] Adenocarcinoma / therapy. Hyperthermia, Induced. Ileal Neoplasms / therapy. Jejunal Neoplasms / therapy

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  • (PMID = 19544356.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Gibson MK, Holcroft CA, Kvols LK, Haller D: Phase II study of 5-fluorouracil, doxorubicin, and mitomycin C for metastatic small bowel adenocarcinoma. Oncologist; 2005 Feb;10(2):132-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II study of 5-fluorouracil, doxorubicin, and mitomycin C for metastatic small bowel adenocarcinoma.
  • BACKGROUND: Small bowel adenocarcinoma is a rare gastrointestinal malignancy that is treated primarily with surgery.
  • This study aimed to document the response rate and survival time for patients with advanced small bowel adenocarcinoma who were not surgically curable and were treated with a regimen of 5-fluorouracil (5-FU), mitomycin C (Mutamycin; Bristol-Myers Squibb; Princeton, NJ), and doxorubicin (Adriamycin; Bedford Laboratories; Bedford, OH), the FAM regimen.
  • CONCLUSIONS: The FAM regimen was active and tolerable for patients with advanced small bowel adenocarcinoma; however, the results were no better than those seen with other chemotherapy combinations.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy

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  • (PMID = 15709215.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; 80168379AG / Doxorubicin; U3P01618RT / Fluorouracil
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99. Ross A, Mehdizadeh S, Tokar J, Leighton JA, Kamal A, Chen A, Schembre D, Chen G, Binmoeller K, Kozarek R, Waxman I, Dye C, Gerson L, Harrison ME, Haluszka O, Lo S, Semrad C: Double balloon enteroscopy detects small bowel mass lesions missed by capsule endoscopy. Dig Dis Sci; 2008 Aug;53(8):2140-3