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[Title] Complete response of an initially non-surgical adenocarcinoma of the duodenum to chemotherapy with the FOLFOX 4 regimen.

INTRODUCTION: The incidence of adenocarcinoma of the small bowel is very low in comparison with that of colorectal cancer.

No standard chemotherapy is defined for non-surgical adenocarcinoma of the small bowel.

CASE REPORT: We report here the case of a young patient with an initially non-surgical adenocarcinoma of the duodenum treated in a palliative setting with the FOLFOX 4 chemotherapy regimen.

CONCLUSION: The FOLFOX 4 regimen seems to be efficacious for some small-bowel adenocarcinomas and can be expected to lead to downstaging.

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy

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(PMID = 19585173.001).

[ISSN] 1873-4626

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol

   

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[Title] Focal amyloidoma of the small bowel mimicking adenocarcinoma on CT.

[MeSH-major] Amyloidosis / radiography. Intestinal Diseases / radiography. Intestine, Small. Tomography, X-Ray Computed

[MeSH-minor] Adenocarcinoma / radiography. Aged. Contrast Media. Diagnosis, Differential. Humans. Intestinal Neoplasms / radiography. Male

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(PMID = 16247131.001).

[ISSN] 0361-803X

[Journal-full-title] AJR. American journal of roentgenology

[ISO-abbreviation] AJR Am J Roentgenol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Contrast Media

   

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[Title] Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center Australian experience.

OBJECTIVE: The objective of the study was to examine diagnosis and outcome in a series of patients with small bowel tumors detected by capsule endoscopy (CE) in three Australian centers.

Seventeen tumors were malignant: five adenocarcinomas, six carcinoids, two melanoma metastases, two gastrointestinal stromal tumors (GIST), one colon carcinoma metastasis, one non-Hodgkin's lymphoma.

Of the five patients with primary adenocarcinoma only one remains disease free.

CONCLUSIONS: Small bowel tumors are a significant finding at CE and are often missed by other methods of investigation.

[MeSH-major] Capsule Endoscopy. Intestinal Neoplasms / pathology. Intestinal Neoplasms / therapy. Intestine, Small

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(PMID = 17032187.001).

[ISSN] 0002-9270

[Journal-full-title] The American journal of gastroenterology

[ISO-abbreviation] Am. J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article; Multicenter Study

[Publication-country] United States

   

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[Title] Proapoptotic effect on normal and tumor intestinal cells of cytostatic drugs with enterohepatic organotropism.

The proapoptotic effect of cisplatin bile acid derivatives Bamet-R2 [cis-diamminechloro-cholylglycinate-platinum(II)] and Bamet-UD2 [cis-diammine-bisursodeoxycholate-platinum(II)], developed to treat liver and intestinal tumors, was investigated in vitro using human enterohepatic cells HepG2 (hepatoblastoma), LS 174T (colon adenocarcinoma), and its cisplatin-resistant subline LS 174T/R.

The degree of necrosis (lactate dehydrogenase release) induced by these three drugs was small and similar in all cell types.

Oral administration of Bamet-UD2 to mice induced mild apoptosis in the small intestine (ileum > duodenum), which was not severe enough to modify its structure or function as determined by water absorption and glycocholic acid uptake by in situ perfused ileum.

These results indicate that Bamet-UD2 overcomes the resistance to cisplatin when this is due in part to enhanced ability of intestinal tumors to reduce intracellular cisplatin contents.

Moreover, its strong proapoptotic versus its weak pronecrotic effect together with its mild effect on normal tissues, including intestinal mucosa, may account for the high antitumor activity of Bamet-UD2 together with its very low toxicity.

[MeSH-major] Antineoplastic Agents / pharmacology. Apoptosis / drug effects. Intestinal Neoplasms / drug therapy. Intestine, Small / drug effects. Organoplatinum Compounds / pharmacology. Ursodeoxycholic Acid / analogs & derivatives

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(PMID = 15985617.001).

[ISSN] 0022-3565

[Journal-full-title] The Journal of pharmacology and experimental therapeutics

[ISO-abbreviation] J. Pharmacol. Exp. Ther.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Bamet-UD2; 0 / DNA Adducts; 0 / Organoplatinum Compounds; 0 / diamminebis(ursodeoxycholate(O,O'))platinum(II); 724L30Y2QR / Ursodeoxycholic Acid

   

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[Title] A rare case of primary small bowel adenocarcinoma with intussusception.

In contrast with the colon tract, the incidence of primary malignancies in the small bowel is very low.

We report the case of a 51-year-old man presenting with jejunal intussusception due to a primary adenocarcinoma.

The patient was referred to our division for bowel obstruction.

Histological examination of the specimen resulted in a diagnosis of a primary adenocarcinoma of the small bowel.

In adult intestinal intussusception, resection without reduction is considered the optimal management if an underlying primary malignancy cannot be excluded.

[MeSH-major] Adenocarcinoma / complications. Intussusception / etiology. Jejunal Diseases / etiology. Jejunal Neoplasms / complications

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(PMID = 20572601.001).

[ISSN] 0300-8916

[Journal-full-title] Tumori

[ISO-abbreviation] Tumori

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] Possible small-bowel neoplasms: contrast-enhanced and water-enhanced multidetector CT enteroclysis.

PURPOSE: To prospectively evaluate the sensitivity and specificity of contrast material-enhanced and water-enhanced multidetector computed tomographic (CT) enteroclysis in depicting small-bowel neoplasms in symptomatic patients, with endoscopic, tissue, and follow-up findings as reference standards.

Two hundred nineteen patients (108 male, 111 female; age range, 17-98 years; mean, 53.1 years) with clinical suspicion of small-bowel neoplasm underwent contrast- and water-enhanced multidetector CT enteroclysis after normal findings of upper and lower gastrointestinal endoscopy.

The prospective interpretations of CT enteroclysis results include evaluation of focal bowel wall thickening, small-bowel masses, small-bowel stenosis, mesenteric stranding, enlarged mesenteric lymph nodes, and visceral metastasis.

The overall sensitivity and specificity in identifying patients with small-bowel lesions were 84.7% and 96.9%, respectively.

Findings of pathologic examination confirmed small-bowel tumor in 50 patients with carcinoid tumor (n = 19), adenocarcinoma (n = 7), lymphoma (n = 5), jejunal adenoma (n = 9), stromal tumor (n = 5), ectopic pancreas (n = 2), angiomatous mass (n = 2), or metastasis (n = 1).

CONCLUSION: Contrast- and water-enhanced multidetector CT enteroclysis had an overall accuracy of 84.7% for depiction of small-bowel neoplasms.

[MeSH-major] Intestinal Neoplasms / radiography. Intestine, Small. Tomography, X-Ray Computed / methods

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Endoscopy, Gastrointestinal. Female. Humans. Iopamidol / analogs & derivatives. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Reference Standards. Sensitivity and Specificity

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[Copyright] (c) RSNA, 2006.

(PMID = 17053201.001).

[ISSN] 0033-8419

[Journal-full-title] Radiology

[ISO-abbreviation] Radiology

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Contrast Media; 17E17JBP8L / iomeprol; JR13W81H44 / Iopamidol

   

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[Title] Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel disease.

PURPOSE: The goal of this study was to compare magnetic resonance enterography (MRE) and video capsule endoscopy (VCE) in suspected small bowel disease.

MATERIALS AND METHODS: Nineteen patients with suspected small bowel disease participated in a prospective clinical comparison of MRE versus VCE.

RESULTS: Small bowel pathologies were found in 15 out of 19 patients: Crohn's disease (n= 5), lymphoma (n= 4), lymphangioma (n= 1), adenocarcinoma (n= 1), postradiation enteropathy (n= 1), NSAID-induced enteropathy (n =1), angiodysplasia (n= 1), and small bowel adhesions (n= 1).

MRE revealed 19 extraenteric findings in 11 patients as well as small bowel adhesions not detected on VCE (n= 1).

Thus, VCE and MRE appear to be complementary methods which, when used in conjunction, may better characterize suspected small bowel disease.

[MeSH-major] Capsule Endoscopy. Intestinal Diseases / diagnosis. Intestine, Small. Magnetic Resonance Imaging / methods

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(PMID = 19086147.001).

[ISSN] 1473-5687

[Journal-full-title] European journal of gastroenterology & hepatology

[ISO-abbreviation] Eur J Gastroenterol Hepatol

[Language] eng

[Publication-type] Comparative Study; Evaluation Studies; Journal Article

[Publication-country] England

   

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[Title] Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma.

We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male.

Adenocarcinoma without stromal invasion was observed adjacent to the small intestinal mucosa.

Immunohistochemistry of the adenocarcinoma tissue revealed p53 overexpression and high Ki-67 labeling index as well as positive staining for CD10, cytokeratin 7, and cytokeratin 20.

Therefore, the diagnosis of small intestinal adenocarcinoma was made.

To our knowledge, this is the first case of small intestinal adenocarcinoma arising in retroperitoneal mature cystic teratoma.

A unique feature of this case is that malignant transformation in retroperitoneal mature teratoma arose even in the fully developed intestine.

[MeSH-major] Adenocarcinoma / pathology. Neoplasms, Multiple Primary / pathology. Retroperitoneal Neoplasms / pathology. Teratoma / pathology

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[Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.

[ErratumIn] Pathol Int. 2010 Dec;60(12):798

(PMID = 20846270.001).

[ISSN] 1440-1827

[Journal-full-title] Pathology international

[ISO-abbreviation] Pathol. Int.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Australia

   

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[Title] Preoperative diagnosis of jejunal adenocarcinoma--a case report.

We report herein the case of a preoperatively diagnosed small bowel adenocarcinoma.

An US-guided fine (20 gauge) needle aspiration (FNA) cytology of the mass was performed and showed moderately differentiated adenocarcinoma of intestinal origin.

On surgical exploration a jejunal tumor of high consistency was found, located 15 cm distantly from the Treitz ligament, infiltrating up to 2/3 of the bowel circumference and partly obstructing its lumen.

The histological evaluation of the resected material showed highly to moderately differentiated adenocarcinoma with 5 regional lymph node metastases.

The combination of US with Doppler and FNA established preoperatively the malignant small bowel disease.

[MeSH-major] Adenocarcinoma / diagnosis. Jejunal Neoplasms / diagnosis

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(PMID = 18404799.001).

[ISSN] 1107-0625

[Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology

[ISO-abbreviation] J BUON

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Greece

   

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[Title] Obstructed small bowel ruptured toward the inguinal canal resulting from metastatic colon carcinoma in an irreducible, recurrent inguinal hernia with mesh-plug repair: Report of a case.

Delayed surgical exploration revealed metastatic cancer with small bowel adhesion to the mesh-plug and perforation.

The mesh-plug with adherent tissue was removed through the inguinal incision, and the ruptured small bowel was resected.

Histopathology revealed moderately differentiated mucinous adenocarcinoma of the tissue adhering to the prosthetic material corresponding to the original colon cancer.

[MeSH-major] Adenocarcinoma / secondary. Hernia, Inguinal / surgery. Intestinal Obstruction / pathology. Intestine, Small / surgery. Sigmoid Neoplasms / pathology

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[Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.

(PMID = 20138732.001).

[ISSN] 1532-2157

[Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

[ISO-abbreviation] Eur J Surg Oncol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

   

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A 72-year-old man was given a diagnosis of Crohn's disease in 1976 at age 44, and partial resection of is ileum was performed.

Ileocecal resection, partial resection of is small intestine and loop sigmoid colostomy were performed.

Endoscopic examination showed a fistula orifice in the rectum and biopsy of the fistula revealed mucinous adenocarcinoma.

[MeSH-major] Adenocarcinoma, Mucinous / etiology. Crohn Disease / complications. Ileal Diseases / complications. Intestinal Fistula / complications. Rectal Fistula / complications. Rectal Neoplasms / etiology

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(PMID = 17917397.001).

[ISSN] 0446-6586

[Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

[ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article; Review

[Publication-country] Japan

[Number-of-references] 12

   

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The aim of the present review was to summarize the current evidence on the role of ultrasonography (US) and doppler-US in the diagnosis of celiac disease.

Firstly, case control studies identified some of these US signs and then in a prospective series some of these parameters, due to their high specificity, have been shown to be of value in confirming CD diagnosis, whereas others, due to their high sensitivity, have been demonstrated to be useful in excluding the presence of the disease.

The last part of this review will deal with the possible role of US in identifying the most severe and common intestinal complication of CD, i.e. the enteropathy-associated T cell non-Hodgkin lymphoma.

[MeSH-minor] Abdomen / blood supply. Abdomen / ultrasonography. Adenocarcinoma / diagnosis. Adenocarcinoma / ultrasonography. Algorithms. Case-Control Studies. Humans. Intestinal Neoplasms / ultrasonography. Intestine, Small / ultrasonography. Lymphoma, Non-Hodgkin / ultrasonography. Prospective Studies. Splanchnic Circulation. Ultrasonography. Ultrasonography, Doppler / methods

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[Cites] N Engl J Med. 2002 Jan 17;346(3):180-8 [11796853.001]

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(PMID = 16534837.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] China

[Number-of-references] 20

[Other-IDs] NLM/ PMC4087888

   

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[Title] Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells.

The site-specific function of multidrug-resistance-associated proteins (MRPs), especially MRP2 and MRP3, was examined in rat intestine and human colon adenocarcinoma (Caco-2) cells.

In contrast, probenecid significantly suppressed both apical and basolateral efflux of DNP-SG in Caco2 cells, though the inhibition was of small magnitude.

In conclusion, the efflux of DNP-SG from enterocytes mediated by MRPs exhibited a significant regional difference in rat intestine, indicating possible variability in intestinal bioavailabilities of MRP substrates, depending on their absorption sites along the intestine.

[MeSH-major] Glutathione / analogs & derivatives. Intestinal Absorption. Membrane Transport Proteins / metabolism. Multidrug Resistance-Associated Proteins / metabolism

[MeSH-minor] Animals. Bile / metabolism. Biological Availability. Biological Transport. Blotting, Western. Caco-2 Cells. Dinitrochlorobenzene. Humans. Ileum / metabolism. Intestinal Mucosa / metabolism. Jejunum / metabolism. Male. Probenecid. Rats. Rats, Sprague-Dawley. Substrate Specificity

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(PMID = 17430634.001).

[ISSN] 0022-3573

[Journal-full-title] The Journal of pharmacy and pharmacology

[ISO-abbreviation] J. Pharm. Pharmacol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Membrane Transport Proteins; 0 / Multidrug Resistance-Associated Proteins; 0 / multidrug resistance-associated protein 2; 0 / multidrug resistance-associated protein 3; 26289-39-4 / S-(2,4-dinitrophenyl)glutathione; GAN16C9B8O / Glutathione; GE3IBT7BMN / Dinitrochlorobenzene; PO572Z7917 / Probenecid

   

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[Title] No association of primary adenocarcinomas of the small bowel with Epstein-Barr virus infection.

Adenocarcinomas of the small bowel comprise a very rare entity, with little knowledge about molecular properties and etiological aspects.

We have investigated the prevalence of EBER expression (EBV-encoded small RNAs) in a series of small bowel adenocarcinomas (n=56) utilizing RNA in situ hybridization (EBER-RISH).

A surgical series of 82 primary resected gastric (n=36) or cardiac (n=46) adenocarcinomas (TU Munich) was used as control group.

None of the 56 small bowel carcinomas exhibited EBER expression whereas in the control group the rate of EBER expression accounted for 4.4% in the group of cardia carcinomas and 8.6% in the group of gastric cancers.

These results indicate that EBV infection plays no etiologic role in primary small bowel adenocarcinomas.

[MeSH-major] Adenocarcinoma / virology. Epstein-Barr Virus Infections / virology. Herpesvirus 4, Human / genetics. Intestinal Neoplasms / virology. Intestine, Small / virology. Stomach Neoplasms / virology

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[Copyright] (c) 2006 Wiley-Liss, Inc.

(PMID = 16493667.001).

[ISSN] 0899-1987

[Journal-full-title] Molecular carcinogenesis

[ISO-abbreviation] Mol. Carcinog.

[Language] eng

[Publication-type] Journal Article; Multicenter Study

[Publication-country] United States

[Chemical-registry-number] 0 / RNA, Viral

   

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Barrett's metaplasia describes the development of a columnar/intestinal phenotype in the squamous oesophageal epithelium and is the major risk factor for oesophageal adenocarcinoma.

The homoeotic transcription factor Cdx2 (Caudal-type homeobox 2) has been implicated as a master switch gene for intestine and therefore for Barrett's metaplasia.

Normally, Cdx2 expression is restricted to the epithelium of the small and large intestine.

Loss of Cdx2 function, or conditional deletion in the intestine, results in replacement of intestinal cells with a stratified squamous phenotype.

In addition, Cdx2 is sufficient to provoke intestinal metaplasia in the stomach.

[MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Animals. CDX2 Transcription Factor. Esophageal Neoplasms / genetics. Esophageal Neoplasms / pathology. Humans. Metaplasia / genetics. Models, Biological

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(PMID = 20298184.001).

[ISSN] 1470-8752

[Journal-full-title] Biochemical Society transactions

[ISO-abbreviation] Biochem. Soc. Trans.

[Language] eng

[Grant] United Kingdom / Medical Research Council / / G0300415; United Kingdom / Cancer Research UK / /

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] England

[Chemical-registry-number] 0 / CDX2 Transcription Factor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins

[Number-of-references] 72

   

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[Title] [Primary adenocarcinoma of jejunum with obscure gastrointestinal bleeding].

[Transliterated title] Adenocarcinoma primitivo del digiuno ad esteriorizzazione con enterorragia.

A case of primary small bowel adenocarcinoma is reported because of the rarity of this malignancy.

[MeSH-major] Adenocarcinoma. Gastrointestinal Hemorrhage / etiology. Jejunal Neoplasms

[MeSH-minor] Capsule Endoscopy. Diagnosis, Differential. Female. Humans. Jejunum / pathology. Middle Aged. Occult Blood. Prognosis

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(PMID = 17147051.001).

[ISSN] 0009-9074

[Journal-full-title] La Clinica terapeutica

[ISO-abbreviation] Clin Ter

[Language] ita

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Italy

   

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Jaw metastases from the gastrointestinal (GI) tract usually evolve from adenocarcinoma of the esophagus, colon, and rectum.

These tumors are thought to arise from Cajal cells in GI tract walls, essential for intestine motor function.

The small intestine harbors only 30% of GIST.

The patient was treated with imatinib but died 11 months after the diagnosis.

DISCUSSION: The prevalence of GIST is low but the true incidence may be higher because of under-diagnosis.

GIST should be included in the differential diagnosis of intramandibular tumor in patients with prior or current non-oral malignancy.

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(PMID = 19010506.001).

[ISSN] 0035-1768

[Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale

[ISO-abbreviation] Rev Stomatol Chir Maxillofac

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] France

[Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit

   

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[Title] Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma.

BACKGROUND: Metastatic small bowel adenocarcinoma (SBA) has a poor prognosis.

The primary tumor site was the jejunum in 35 patients (43%), duodenum in 30 patients (38%), ileum in 6 patients (8%), and nonspecified small bowel in 9 patients (11%).

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology

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[Copyright] (c) 2008 American Cancer Society.

(PMID = 18759326.001).

[ISSN] 0008-543X

[Journal-full-title] Cancer

[ISO-abbreviation] Cancer

[Language] eng

[Grant] United States / NCI NIH HHS / CA / P30 CA016672

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Platinum Compounds; U3P01618RT / Fluorouracil

   

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[Title] Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study.

However, the coexistence of neurofibromatosis with small-bowel adenocarcinoma is exceedingly rare.

We present an uncommon case of neurofibromatosis type 1, involving the small bowel in a 73-year-old man, who was admitted to our department with signs of acute abdomen.

These nodules obstructed ileal lumen, while the intestine wall was perforated in one point.

Histology revealed neurofibromatosis type 1 with malignant transformation to small-bowel adenocarcinoma.

We suggest that adenocarcinoma of small bowel should be considered in the evaluation of acute abdominal pain in neurofibromatosis patients.

[MeSH-major] Adenocarcinoma / pathology. Ileal Neoplasms / pathology. Intestine, Small / pathology. Neoplasms, Multiple Primary / pathology. Neurofibromatosis 1 / pathology

[MeSH-minor] Abdomen, Acute / etiology. Aged. Follow-Up Studies. Humans. Intestinal Obstruction / etiology. Intestinal Obstruction / pathology. Male. Tomography, X-Ray Computed

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(PMID = 19473375.001).

[ISSN] 1365-2354

[Journal-full-title] European journal of cancer care

[ISO-abbreviation] Eur J Cancer Care (Engl)

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

   

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Coeliac disease may have an ancient history dating back to the 1st and 2nd centuries AD.

Dicke's colleagues, Weijers and Van de Kamer, showed that measurement of stool fat reflected the clinical condition.

Histological abnormalities of the lining of the small intestine were demonstrated beyond doubt by Paulley in 1954 and techniques of per-oral biopsy described by Royer in 1955 and Shiner in 1956 afforded reliable diagnosis.

Lymphoma, adenocarcinoma and ulceration of the small intestine and a range of immunological disorders are associated.

[MeSH-minor] Dermatitis Herpetiformis / etiology. Dermatitis Herpetiformis / history. History, 19th Century. History, 20th Century. History, Ancient. Humans. Intestinal Neoplasms / etiology. Intestinal Neoplasms / history. Intestine, Small / pathology. Lymphoma / etiology. Lymphoma / history. Transglutaminases / metabolism. Ulcer / etiology. Ulcer / history

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[Copyright] 2008 S. Karger AG, Basel.

(PMID = 18431060.001).

[ISSN] 1421-9875

[Journal-full-title] Digestive diseases (Basel, Switzerland)

[ISO-abbreviation] Dig Dis

[Language] eng

[Publication-type] Historical Article; Journal Article; Review

[Publication-country] Switzerland

[Chemical-registry-number] EC 2.3.2.13 / Transglutaminases

[Number-of-references] 96

   

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[Title] Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease.

Small intestinal biopsy and bone mineral density were investigated in 2001 and clinical features were followed up until 2005.

RESULTS: Thirteen coeliac patients had persistent small intestinal villous atrophy despite maintaining gluten-free diet.

In 2005, two of the non-responders had developed symptomatic refractory sprue, one died of lymphoma and one of carcinoid tumour, and one gastric adenocarcinoma was operated.

[MeSH-major] Celiac Disease / diet therapy. Intestine, Small / pathology. Lymphoma / etiology

[MeSH-minor] Adult. Aged. Atrophy. Female. Humans. Intestinal Mucosa / pathology. Middle Aged. Patient Care

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(PMID = 17451570.001).

[ISSN] 0269-2813

[Journal-full-title] Alimentary pharmacology & therapeutics

[ISO-abbreviation] Aliment. Pharmacol. Ther.

[Language] eng

[Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

[Publication-country] England

   

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[Title] [A case report of primary adenocarcinoma of small intestine].

This is an account of a case of primary adenocarcinoma of the small intestine with peritoneal dissemination successfully treated with chemotherapy.

Abdominal computerized tomography revealed a bowel obstruction with tumor and the remarkable small bowel dilation of oral side of tumor.

Pathological diagnosis of the resected specimen was adenocarcinoma with lymph nodes metastasis.

The peritoneal dissemination consisted of metastatic adenocarcinoma from small intestine.

Primary small intestinal adenocarcinoma is a rare disease, and it is often diagnosed as advanced cancer because of few characteristic symptoms.

So carcinoma of the small intestine usually has a poor prognosis.

[MeSH-major] Adenocarcinoma / therapy. Intestinal Neoplasms / therapy

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(PMID = 21224715.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Organoplatinum Compounds; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 2S9ZZM9Q9V / Bevacizumab; 5VT6420TIG / Oxonic Acid; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol

   

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[Title] [Primary small bowel adenocarcinoma].

[Transliterated title] Adenocarcinoma primario de intestino delgado.

INTRODUCTION: Primary small bowel adenocarcinoma is an uncommon tumour, with non-specific symptoms that cause a delay in the diagnosis and consequently a worse outcome for the patient.

MATERIAL AND METHOD: We performed a retrospective study of our experience with 17 patients diagnosed with primary small bowel adenocarcinoma, excluding all the cases suggesting secondary involvement of the small bowel from an adenocarcinoma in other locations.

Those with duodenal tumours underwent 4 pancreaticoduodenectomies, 3 gastroenterostomies and 1 diagnostic biopsy; 6 bowel resections with lymphadenectomy, 2 en-bloc resections and 1 by-pass were performed on those with jejuno-ileal tumours.

CONCLUSIONS: Curative treatment consists of small bowel resection.

[MeSH-major] Adenocarcinoma. Duodenal Neoplasms. Ileal Neoplasms. Jejunal Neoplasms

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(PMID = 19344893.001).

[ISSN] 0009-739X

[Journal-full-title] Cirugía española

[ISO-abbreviation] Cir Esp

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Spain

   

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Basopholic intracytoplasmic viral matrix inclusions (MIs) were widely distributed in the chickens affected with subcutaneous myxoma rhabdomyosarcoma, perineuroma, glioma, intra-abdominal adenocarcinoma, and nephroblastoma.

They were also present in the smooth muscle cells of the arteries in the spleen and lungs, in the smooth muscle of the digestive tract muscular layer (crop, oesophagus, proventriculus, gizzard, duodenum, jejunum, ileum, caecum, and large intestine), and in the smooth muscle of the capsule in the ovary and pancreas.

They consisted of electron-dense small granules and ring-shaped particles.

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(PMID = 17364510.001).

[ISSN] 0307-9457

[Journal-full-title] Avian pathology : journal of the W.V.P.A

[ISO-abbreviation] Avian Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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We also determined the protective effects of single large and multiple small doses of palifermin.

Tumor-bearing DA rats were treated with a single large (10 mg/kg) dose of palifermin 3 days prior to, or multiple small (3 mg/kg day for 3 days) doses of palifermin or vehicle control prior to, receiving 2 doses of 150 mg/kg irinotecan.

Small and large intestinal weights were maintained.

Intestinal morphometry was not maintained in palifermin-pretreated rats despite being increased prior to irinotecan treatment.

Palifermin pretreatment did not prevent apoptosis that peaked at 6 hr in the jejunum or colon, but prevented apoptosis at 96 hr in the small intestine.

[MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / veterinary. Animals. Female. Fibroblast Growth Factor 7. Keratinocytes. Mammary Neoplasms, Animal / drug therapy. Rats. Survival Analysis

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(PMID = 15800945.001).

[ISSN] 0020-7136

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Fgf7 protein, rat; 126469-10-1 / Fibroblast Growth Factor 7; 62031-54-3 / Fibroblast Growth Factors; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin

   

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In vivo imaging could greatly facilitate these trials, but the small size of the animals is a major limitation for the direct visualization of intestinal tissue.

Here we report a method of in vivo imaging of the mouse intestine based on X-ray micro-computed tomography using multiple contrast agents.

This method was validated in the model of non-cancerous polyp-like heteroplasia that spontaneously develops in the caecum area of Cdx2+/- mutant mice and in the model of colon adenocarcinoma induced by administration of the chemical carcinogen azoxymethane.

As a simple and non-invasive method, multiple-contrast X-ray micro-computed tomography is appropriate for pre-clinical studies of intestinal diseases in living mice.

[MeSH-minor] Animals. Equipment Design. Heterozygote. Homeodomain Proteins / genetics. Intestinal Diseases / radiography. Male. Mice. Mice, Knockout. Transcription Factors / deficiency. Transcription Factors / genetics

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(PMID = 17923376.001).

[ISSN] 1631-0691

[Journal-full-title] Comptes rendus biologies

[ISO-abbreviation] C. R. Biol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] France

[Chemical-registry-number] 0 / Cdx2 protein, mouse; 0 / Homeodomain Proteins; 0 / Transcription Factors

   

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Unconfirmed partial responses were observed in two patients, one with metastatic small bowel adenocarcinoma and the other with metastatic esophageal cancer.

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(PMID = 16278410.001).

[ISSN] 1078-0432

[Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research

[ISO-abbreviation] Clin. Cancer Res.

[Language] eng

[Grant] United States / NCRR NIH HHS / RR / M01 RR00032

[Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents; 30IQX730WE / Polyethylene Glycols; 581079-18-7 / pegamotecan; XT3Z54Z28A / Camptothecin

   

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[Title] [Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report].

[Transliterated title] Adénocarcinome de l'intestin grêle compliquant une maladie coeliaque de l'adulte: à propos d'un cas.

This small bowel adenocarcinoma is rare and concerns less than 5% of the digestive neoplasias.

We are reporting the case of a 67-years-old woman whose coeliac disease has been complicated 5 years thereafter by a jejunal adenocarcinoma.

[MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Celiac Disease / complications. Incidental Findings. Jejunal Neoplasms / complications. Jejunal Neoplasms / diagnosis

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(PMID = 19777919.001).

[ISSN] 0370-629X

[Journal-full-title] Revue médicale de Liège

[ISO-abbreviation] Rev Med Liege

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Belgium

   

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[Title] Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system.

Cadherin-17, also called liver-intestine cadherin, is a calcium-dependent transmembrane glycoprotein that mediates cell-cell adhesion in intestinal epithelium.

Expression of cadherin-17 was reported in gastric, pancreatic, and colorectal adenocarcinomas but not in other tumors.

Whether cadherin-17 can be used as a marker for diagnosis of cancers is still unclear.

Among normal tissues, the expression of cadherin-17 was limited to epithelial cells of small intestine and colon.

Colorectal adenocarcinomas showed staining in 96% of cases and most of them had strong and diffuse staining.

Gastric, pancreatic, and biliary adenocarcinomas showed diffuse or scattered staining in about 25-50% of cases.

When a two-marker, Cadherin-17/cytokeratin 7, profile was used, 37 of 38 (97%) cadherin-17(+)/cytokeratin 7(-) tumors were colorectal adenocarcinomas; 49 of 56 (86%) cadherin-17(+)/cytokeratin 7(+) tumors were gastric, pancreatic, or biliary adenocarcinomas.

Our results show that cadherin-17 is a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.

[MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Cadherins / analysis. Gastrointestinal Neoplasms / diagnosis

[MeSH-minor] Colorectal Neoplasms / chemistry. Colorectal Neoplasms / diagnosis. Female. Humans. Immunoenzyme Techniques. Male. Pancreatic Neoplasms / chemistry. Pancreatic Neoplasms / diagnosis. Stomach Neoplasms / chemistry. Stomach Neoplasms / diagnosis

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(PMID = 18552820.001).

[ISSN] 1530-0285

[Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

[ISO-abbreviation] Mod. Pathol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDH17 protein, human; 0 / Cadherins

   

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[Title] Enhanced expression of hepatocyte growth factor activator inhibitor type 2-related small peptide at the invasive front of colon cancers.

BACKGROUND: Hepatocyte growth factor activator inhibitor type 2-related small peptide (H2RSP) is a small nuclear protein abundantly expressed in the gastrointestinal epithelium.

AIMS: To investigate the expression and localisation of H2RSP in normal, injured and neoplastic human intestinal tissue.

METHODS: Immunohistochemical examination and in situ hybridisation for H2RSP were performed using normal and diseased intestinal specimens.

RESULTS: In the normal intestine, H2RSP was observed in the nuclei of surface epithelial cells and this nuclear localisation was impaired in regenerating epithelium.

H2RSP expression was down regulated in well-differentiated colorectal adenocarcinomas.

The number of H2RSP-positive cells in the invasive front of well-differentiated adenocarcinomas was considerably higher in the cases with lymph node metastases than in node-negative ones.

CONCLUSION: In the normal intestine, the nuclear accumulation of H2RSP is a marker of differentiated epithelial cells.

Although H2RSP was down regulated in colorectal adenocarcinomas, a paradoxical up regulation was observed in actively invading carcinoma cells.

[MeSH-major] Adenocarcinoma / chemistry. Colonic Neoplasms / chemistry. Neoplasm Proteins / analysis. Nuclear Proteins / analysis. Transcription Factors / analysis

[MeSH-minor] Adenoma / chemistry. Adenoma / immunology. Adenoma / pathology. Animals. CHO Cells. Cell Count. Cell Differentiation / physiology. Cell Division / physiology. Cell Line, Tumor. Colitis, Ulcerative / immunology. Colitis, Ulcerative / pathology. Colorectal Neoplasms / chemistry. Colorectal Neoplasms / immunology. Colorectal Neoplasms / pathology. Cricetinae. Cricetulus. Epithelial Cells / chemistry. Epithelial Cells / immunology. Epithelial Cells / pathology. Humans. Hyperplasia. Immunohistochemistry / methods. In Situ Hybridization / methods. Intestinal Polyps / chemistry. Intestinal Polyps / immunology. Intestinal Polyps / pathology. Intestines / chemistry. Intestines / immunology. Intestines / pathology. Lymphatic Metastasis. Neoplasm Invasiveness. beta Catenin / analysis

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(PMID = 16809422.001).

[ISSN] 0017-5749

[Journal-full-title] Gut

[ISO-abbreviation] Gut

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / C19orf33 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / beta Catenin

[Other-IDs] NLM/ PMC1856747

   

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[Title] [A case of jejunal adenocarcinoma with serum DUPAN-2 elevation].

Ileus with ulcerated jejunal tumor was diagnosed and biopsy revealed adenocarcinoma.

Surgical resection was performed: both tumors were adenocarcinoma, but the ovarian tumor was considered to be metastatic clinically and histologically.

This case shows a possible relation between small bowel adenocarcinoma and DUPAN-2.

[MeSH-major] Adenocarcinoma / diagnosis. Antigens, Neoplasm / blood. Jejunal Neoplasms / diagnosis

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(PMID = 21071898.001).

[ISSN] 0446-6586

[Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

[ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DU-PAN-2 antigen, human

   

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The most common localization is the small intestine.

We report on a 94-year-old man with gastric PI associated with inoperable adenocarcinoma localized in the duodenum.

We suggest that in patients presenting with PI, malignancy should be considered in the differential diagnosis.

[MeSH-major] Adenocarcinoma / diagnosis. Duodenal Neoplasms / diagnosis. Pneumatosis Cystoides Intestinalis / diagnosis. Pneumatosis Cystoides Intestinalis / radiography

[MeSH-minor] Aged, 80 and over. Blood Proteins / analysis. Blood Proteins / isolation & purification. Diagnosis, Differential. Fatal Outcome. Humans. Male. Stomach Diseases / diagnosis. Stomach Diseases / etiology. Stomach Diseases / radiography. Tomography, X-Ray Computed. Urine / cytology

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[Cites] Pediatr Radiol. 2001 Sep;31(9):656-8 [11512009.001]

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(PMID = 19222105.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Blood Proteins

[Other-IDs] NLM/ PMC2653449

   

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As a consequence of the injury, the villi and crypt structures of the small intestine disappeared, leading to profuse bleeding and death.

In both cases, lethal and sub-lethal doses, the target of nigrin b appeared to be the highly proliferating stem cells of the intestinal crypts, which had undergone apoptotic changes.

Nigrin b killed COLO 320 human colon adenocarcinoma cells with an IC(50) of 3.1 x 10(-8) M and the effect was parallel to the extent of DNA fragmentation of these cells.

Accordingly, despite the low general toxicity exerted by nigrin b as compared with ricin, intravenous injection of large amounts of nigrin b is able to kill mouse intestinal stem cells without threatening the lives of the animals, thereby opening a door for its use for the targeting of intestinal stem cells.

[MeSH-major] Intestine, Small / drug effects. N-Glycosyl Hydrolases / toxicity. Plant Proteins / toxicity

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(PMID = 16102565.001).

[ISSN] 0041-008X

[Journal-full-title] Toxicology and applied pharmacology

[ISO-abbreviation] Toxicol. Appl. Pharmacol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Plant Proteins; 0 / Ribosome Inactivating Proteins, Type 2; 9009-86-3 / Ricin; EC 3.2.2.- / N-Glycosyl Hydrolases

   

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METHODS AND MATERIALS: Between December 1996 and January 2002, 27 patients with prostate adenocarcinoma were treated with conformal WPRT as part of their definitive treatment.

Dose-volume histograms for the bowel, bladder, and rectum were compared for the three techniques.

RESULTS: Three-dimensional-CRT resulted in a 40% relative reduction (p < 0.001) in the volume of bowel receiving 45 Gy compared with 2D, and IMRT provided a further 60% reduction relative to 3D-CRT (p < 0.001).

CONCLUSIONS: Compared to conventional 2D planning, conformal planning for WPRT resulted in significant reductions in the doses delivered to the bowel, rectum, and bladder.

IMRT was superior to 3D-CRT in limiting the volume of bowel and rectum within high-dose regions.

[MeSH-minor] Adult. Aged. Aged, 80 and over. Colon / radiation effects. Diarrhea / etiology. Humans. Intestine, Small / radiation effects. Male. Middle Aged. Pelvis. Radiation Dosage. Radiotherapy, Intensity-Modulated / adverse effects. Radiotherapy, Intensity-Modulated / methods. Rectum / radiation effects. Urinary Bladder / radiation effects. Urination Disorders / etiology

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(PMID = 15913914.001).

[ISSN] 0360-3016

[Journal-full-title] International journal of radiation oncology, biology, physics

[ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases.

BACKGROUND: Small bowel adenocarcinoma is a rare cancer that has generally been considered resistant to chemotherapy, although little has been published on the role of chemotherapy.

A retrospective analysis was conducted of patients with advanced small bowel adenocarcinoma to explore chemotherapy use, and gain knowledge for ongoing management and future clinical trials.

PATIENTS AND METHODS: All patients with advanced adenocarcinoma of the small bowel treated at Princess Margaret Hospital (PMH) between 1986 and 2004 were identified through the cancer registry.

CONCLUSION: Chemotherapy appears to have activity in adenocarcinoma of the small bowel.

[MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestinal Neoplasms / pathology

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(PMID = 16755174.001).

[ISSN] 1537-453X

[Journal-full-title] American journal of clinical oncology

[ISO-abbreviation] Am. J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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BACKGROUND: There is very small occurrence of adenocarcinoma in the small bowel.

We present a case of primary duodenal adenocarcinoma and discuss the findings of the case diagnostic modalities, current knowledge on the molecular biology behind small bowel neoplasms and treatment options.

CASE: The patient had a history of iron deficiency anemia and occult bleeding with extensive workup consisting of upper endoscopy, colonoscopy, capsule endoscopy, upper gastrointestinal series with small bowel follow through and push enteroscopy.

Due to persistent abdominal pain and iron deficiency anemia the patient underwent push enteroscopy which revealed adenocarcinoma of the duodenum.

The patient underwent en-bloc duodenectomy which revealed T3N1M0 adenocarcinoma of the 4th portion of the duodenum.

CONCLUSIONS: Primary duodenal carcinoma, although rare should be considered in the differential diagnosis of occult gastrointestinal bleeding when evaluation of the lower and upper GI tract is unremarkable.

We discuss the current evaluation and management of this small bowel neoplasm.

[MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Duodenal Neoplasms / diagnosis

[MeSH-minor] Aged. Diagnosis, Differential. Duodenoscopy. Female. Humans. Laparotomy. Ligaments. Tomography, X-Ray Computed

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(PMID = 20849628.001).

[ISSN] 1471-230X

[Journal-full-title] BMC gastroenterology

[ISO-abbreviation] BMC Gastroenterol

[Language] eng

[Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor

[Other-IDs] NLM/ PMC2949773

   

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[Title] [Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer), hereditary predisposition to colorectal and endometrial adenocarcinomas].

[Transliterated title] Identification et prise en charge du syndrome HNPCC (hereditary non polyposis colon cancer). Prédisposition héréditaire aux cancers du côlon, du rectum et de l'utérus.

Patients affected by the disease are at high risk for colorectal and endometrial carcinomas, but also for small intestine, urothelial, ovary, stomach and biliary tract carcinomas.

[MeSH-major] Adenocarcinoma / genetics. Colonic Neoplasms / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Endometrial Neoplasms / genetics. Rectal Neoplasms / genetics

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(PMID = 16677780.001).

[ISSN] 0369-8114

[Journal-full-title] Pathologie-biologie

[ISO-abbreviation] Pathol. Biol.

[Language] fre

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] France

[Number-of-references] 97

   

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[Title] Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient.

[MeSH-major] Adenocarcinoma / pathology. Crohn Disease / etiology. Ileal Neoplasms / pathology. Intestinal Obstruction / etiology

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(PMID = 19280822.001).

[ISSN] 0003-1348

[Journal-full-title] The American surgeon

[ISO-abbreviation] Am Surg

[Language] eng

[Publication-type] Case Reports; Letter

[Publication-country] United States

   

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[Title] Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway.

Celiac disease (CD) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma.

We hypothesized that CIM may link CD to small bowel carcinogenesis.

We determined microsatellite instability (MSI), CIM, and expression of MLH1 and MGMT in 3 CD-associated small bowel carcinomas and corresponding non-neoplastic mucosa.

The results were compared to those of small bowel mucosa from CD patients without carcinoma and 20 small bowel carcinomas from a non-CD origin.

In conclusion, our data reveal that the high-level CIM/MSI pathway is typical of CD-associated small bowel carcinomas and indicate that aberrant CpG island methylation links CD and carcinogenesis.

The data further suggest that CD should be considered in patients with small bowel adenocarcinoma, particularly when the tumors display MSI.

[MeSH-major] Adenocarcinoma / genetics. Celiac Disease / genetics. CpG Islands. DNA Methylation. Intestinal Neoplasms / genetics. Microsatellite Instability

[MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adult. Aged. Aged, 80 and over. Cohort Studies. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Humans. Intestinal Mucosa / metabolism. Intestinal Mucosa / pathology. Intestine, Small / metabolism. Intestine, Small / pathology. Male. Middle Aged. Nuclear Proteins / genetics. Signal Transduction / genetics. Tumor Suppressor Proteins / genetics

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(PMID = 21042749.001).

[ISSN] 1791-2431

[Journal-full-title] Oncology reports

[ISO-abbreviation] Oncol. Rep.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes

   

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[Title] A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy.

Small bowel adenocarcinoma (SBA) in patients with Crohn's disease (CD) is quite rare, difficult to diagnose without surgery, and has a poor prognosis.

PET/CT detected an accumulation spot in the small bowel.

An endoscopic forceps biopsy specimen showed poorly differentiated adenocarcinoma.

There were some longitudinal ulcer scars near the tumor, and the chronic inflammation in the small bowel appeared to be associated with the cancer development.

Since early diagnosis is extremely difficult in these cases, novel techniques, such as PET/CT and DBE, may be expected to help in making a preoperative diagnosis of the development of SBA in CD.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / etiology. Crohn Disease / complications. Endoscopy, Gastrointestinal / methods. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / etiology. Intestine, Small / pathology

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(PMID = 19360924.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] China

[Other-IDs] NLM/ PMC2668786

   

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[Title] Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon.

METHODS: We examined efficacy of BB in inhibition of azoxymethane (AOM)-induced colon ACF and intestine tumors in male and female Sprague-Dawley rats (outbred strain).

There was a tendency (0.1 > P > 0.05) for fewer adenocarcinomas (relative to total of adenomatous polyps plus adenocarcinomas) in colons of female than male tumor-bearing rats; in small intestine, this gender difference was significant (P < 0.05).

BB favored (P < 0.05) fewer adenocarcinomas and more adenomatous polyps (as a proportion of total tumor number) in female rat small intestine.

Data indicate the potential for slowing tumor progression (adenomatous polyp to adenocarcinoma) by BB.

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(PMID = 19758446.001).

[ISSN] 1471-230X

[Journal-full-title] BMC gastroenterology

[ISO-abbreviation] BMC Gastroenterol

[Language] ENG

[Grant] United States / NCI NIH HHS / CB / N02-CB-07008

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] England

[Chemical-registry-number] 0 / C-Peptide; MO0N1J0SEN / Azoxymethane

[Other-IDs] NLM/ PMC2752457

   

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[Title] Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases.

Small intestinal adenocarcinoma is a rare malignant neoplasm, and its clinicopathologic characteristics have not been well elucidated.

A total of 197 small intestinal adenocarcinoma cases were collected from 22 institutions in South Korea and were evaluated for clinicopathologic factors that affect the prognosis of small intestinal adenocarcinoma patients using univariate and multivariate analyses.

The median survival time for all small intestinal adenocarcinoma patients was 39.7 months.

Compared with small intestinal adenocarcinomas without accompanying sporadic adenomas, small intestinal adenocarcinomas with accompanying adenomas were more well differentiated (P < .0001), with a more polypoid growth pattern (P < .0001), a lower pT classification (P < .0001), less perineural invasion (P = .01), and less lymphatic invasion (P = .03).

Small intestinal adenocarcinoma patients with associated sporadic adenomas (77%) had a significantly better 5-year survival rate than those without sporadic adenomas (38%, P = .02).

By univariate analysis, small intestinal adenocarcinoma patients had significantly different survival based on pT classification (P = .003), lymph node metastasis (P < .0001), distal location (jejunal and ileal carcinomas) (P = .003), retroperitoneal tumor seeding (P < .0001), vascular invasion (P = .007), lymphatic invasion (P = .001), peritumoral dysplasia (P = .004), and radiation therapy (P = .006).

In conclusion, (1) small intestinal adenocarcinomas are diagnosed at an advanced disease stage; therefore, the development of strategies for detection at an earlier stage is needed. (2) Small intestinal adenocarcinoma patients with an adenomatous component had a better survival than those without an adenomatous component. (3) Lymph node metastasis and distal location (jejunum and ileum) of tumor are the most important independent prognostic factors.

[MeSH-major] Adenocarcinoma / pathology. Duodenal Neoplasms / pathology. Ileal Neoplasms / pathology. Jejunal Neoplasms / pathology

[MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intestine, Small / pathology. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Prognosis

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[Copyright] 2010 Elsevier Inc. All rights reserved.

(PMID = 20334897.001).

[ISSN] 1532-8392

[Journal-full-title] Human pathology

[ISO-abbreviation] Hum. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] [Amyloidosis of the small intestine following whipple operation is a rare cause of chronic ileus and has to be considered as differential diagnosis].

[Transliterated title] Die Amyloidose des Dünndarms als seltene Differenzialdiagnose eines chronischen Ileus nach Whipple-Operation.

In this paper we report that secondary amyloidosis of the small intestine can produce similar symptoms and has to be evaluated as a rare differential diagnosis in chronic ileus.

Instead severe adhesions of the small intestine were detected.

The entire small intestine was covered with a substance that had a similar aspect to sugar icing.

Thereby the motility of the small intestine was constricted.

An extensive adhaesiolysis and a decompression of the bowel was carried out.

Diffuse amyloid deposits were found on the small intestine.

One man died four months later, after transfer to a geriatric hospital, because of intestinal atony and a serious senile depression.

Surgeons have to keep in mind that amyloidosis is a possible differential diagnosis in addition to relapse of tumour growth and peritoneal carcinomatosis in these patients.

[MeSH-major] Adenocarcinoma, Papillary / surgery. Amyloidosis / diagnosis. Cystadenoma, Mucinous / surgery. Ileus / diagnosis. Intestinal Diseases / diagnosis. Intestine, Small. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Postoperative Complications / diagnosis

[MeSH-minor] Aged. Aged, 80 and over. Chronic Disease. Diagnosis, Differential. Fatal Outcome. Female. Humans. Male. Tissue Adhesions / diagnosis. Tissue Adhesions / pathology. Tissue Adhesions / surgery

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[Copyright] Georg Thieme Verlag Stuttgart ˙ New York.

(PMID = 20464655.001).

[ISSN] 1438-9592

[Journal-full-title] Zentralblatt für Chirurgie

[ISO-abbreviation] Zentralbl Chir

[Language] ger

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Germany

   

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[Title] Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma.

[MeSH-major] Acetabulum. Adenocarcinoma / secondary. Bone Neoplasms / secondary. Jejunal Neoplasms / pathology

[MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed

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(PMID = 18040646.001).

[ISSN] 0949-2658

[Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

[ISO-abbreviation] J Orthop Sci

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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[Title] A patient with adenocarcinoma of the jejunum successfully diagnosed by preoperative endoscopy for the small intestine.

In this study, the authors report the case of a 35-year-old man diagnosed preoperatively as having adenocarcinoma of the jejunum using a conventional endoscopy, usually used for the examination of the large intestine.

[MeSH-major] Adenocarcinoma / pathology. Endoscopy. Jejunal Neoplasms / pathology

[MeSH-minor] Adult. Humans. Ileus / diagnosis. Ileus / etiology. Ileus / surgery. Intestine, Small. Male

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(PMID = 18795691.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Greece

   

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BACKGROUND: Barrett's oesophagus is an important clinical problem that can lead to oesophageal adenocarcinoma.

To determine the feasibility of using EDTA to strip intestinal type mucosa, segments of the small intestine were exposed in vitro to EDTA at various concentrations with or without agitation.

The conditions required for EDTA to strip mucosa from a vascularized loop of small bowel were then optimized in vivo.

Cannulated small bowel loops were irrigated with different concentrations of EDTA with or without pulsation of the irrigation solution.

Mucosal healing after EDTA stripping was studied in an isolated small bowel loop survival model.

RESULTS: Ethylenediaminetetraacetic acid with agitation or pulsation resulted in stripping of the intestinal columnar mucosa in vitro and in vivo.

In the survival model the small bowel mucosa regenerated without stricture formation.

CONCLUSION: Small bowel columnar mucosa can be removed by EDTA in vivo without stricture formation.

[MeSH-major] Chelating Agents / pharmacology. Edetic Acid / pharmacology. Esophagus / drug effects. Intestinal Mucosa / drug effects. Jejunum / drug effects

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(PMID = 16768702.001).

[ISSN] 1445-1433

[Journal-full-title] ANZ journal of surgery

[ISO-abbreviation] ANZ J Surg

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Australia

[Chemical-registry-number] 0 / Chelating Agents; 9G34HU7RV0 / Edetic Acid

   

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These tumours originate in Cajal interstitial cells and the majority are located in the stomach and small intestine.

Imaging difficulties impede an early diagnosis; sometimes these tumours represent an unexpected intraoperative finding or an emergency abdominal picture.

One patient, with two synchronous gastric neoplasms (GIST + adenocarcinoma) died after 16 months, while the other 5 patients with gastric GIST are still alive; two patients with ileal GIST, treated with chemotherapy, died after 15 and 18 months, respectively.

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(PMID = 19536989.001).

[ISSN] 0009-4773

[Journal-full-title] Chirurgia italiana

[ISO-abbreviation] Chir Ital

[Language] ita

[Publication-type] English Abstract; Journal Article

[Publication-country] Italy

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate

   

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[Title] Colonic cancer in a patient with intestinal malrotation: a case report.

We present a case of a 76-year-old patient with intestinal malrotation, with incomplete rotation of the small intestine and abnormal positioning of the duodenum and superior mesenteric vessels over the transverse colon.

[MeSH-major] Adenocarcinoma / complications. Colonic Neoplasms / complications. Digestive System Abnormalities / complications. Intestinal Diseases / congenital. Intestines / abnormalities

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[Cites] World J Gastroenterol. 2006 Sep 7;12(33):5399-400 [16981277.001]

[Cites] J Am Coll Surg. 2004 Oct;199(4):628-35 [15454150.001]

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(PMID = 20683743.001).

[ISSN] 1128-045X

[Journal-full-title] Techniques in coloproctology

[ISO-abbreviation] Tech Coloproctol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

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[Title] Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.

Patients with long-standing ulcerative colitis and Crohn's disease have an increased risk of developing colorectal cancer and patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.

Colorectal cancer appearing on the ground of inflammatory bowel disease is the result of a process which is believed to begin from no dysplasia progressing to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma, although colorectal cancer can arise without proceeding through each of these steps.

[MeSH-major] Cell Transformation, Neoplastic. Colorectal Neoplasms / epidemiology. Inflammatory Bowel Diseases / epidemiology

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(PMID = 19596953.001).

[ISSN] 1791-7530

[Journal-full-title] Anticancer research

[ISO-abbreviation] Anticancer Res.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Greece

[Number-of-references] 94

   

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[Title] CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach.

CDX2 and liver-intestine (LI)-cadherin are intestine-specific markers and both are physiologically expressed in the small intestine and colon.

Overexpression of CDX2 was significantly associated with CDH17 in gastric adenocarcinoma.

Furthermore, the expression of CDX2 and LI-cadherin proteins was strongly coupled in intestinal metaplasia.

[MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Cadherins / metabolism. Homeodomain Proteins / metabolism. Stomach Neoplasms / metabolism

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(PMID = 15732140.001).

[ISSN] 0022-3417

[Journal-full-title] The Journal of pathology

[ISO-abbreviation] J. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDH17 protein, human; 0 / CDX2 protein, human; 0 / Cadherins; 0 / Homeodomain Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger

   

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[Title] Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database.

BACKGROUND: The presence of distant metastases and the completeness of resection are important prognostic factors in patients with small bowel adenocarcinoma (SBA); however, the influence of lymph node metastasis on patient outcome has not been well characterized.

[MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small. Lymph Nodes / pathology

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[Copyright] Copyright © 2010 American Cancer Society.

(PMID = 20715162.001).

[ISSN] 0008-543X

[Journal-full-title] Cancer

[ISO-abbreviation] Cancer

[Language] eng

[Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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Helicobacter pylori is a Gram-negative spiral bacterium that causes gastritis and peptic ulcer and has been implicated in the pathogenesis of gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma.

We demonstrate here that Peyer's patches (PPs) in the small intestine play critical roles in H. pylori-induced gastritis; no gastritis is induced in H. pylori-infected mice lacking PPs.

We propose that H. pylori converts to the coccoid form in the anaerobic small intestine and stimulates the host immune system through PPs.

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[Cites] J Exp Med. 2000 Mar 6;191(5):771-80 [10704459.001]

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(PMID = 17502608.001).

[ISSN] 0027-8424

[Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America

[ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, Bacterial; 0 / DNA-Binding Proteins; 0 / Rag2 protein, mouse

[Other-IDs] NLM/ PMC1885612

   

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[Title] Small bowel adenocarcinoma in patients with Crohn's disease compared with small bowel adenocarcinoma de novo.

BACKGROUND: Data concerning small bowel adenocarcinoma (SBA) in Crohn's disease (CD) come from case reports and small retrospective series.

The aim of this study was to further describe SBA in patients with CD and compare it with SBA de novo.

METHODS: Twenty patients with CD with SBA recruited in French university hospitals were studied and compared with 40 patients with SBA de novo recruited from a population-based registry.

SBA occurred after a median time of 15 years of CD and was located within the inflamed areas of the ileum (n=19) or jejunum (n=1), whereas in patients with SBA de novo, it was distributed all along the small intestine.

Median age at diagnosis of SBA was 47 years (range, 33-72 yr) in patients with CD and 68 years (range, 41-95 yr) in those with SBA de novo.

Diagnosis was made preoperatively in 1/20 patients with CD and 22/40 patients with SBA de novo.

Signet ring cells were found in 35% of patients with CD but not in patients with SBA de novo.

CONCLUSIONS: SBA in CD is different from SBA de novo.

[MeSH-major] Adenocarcinoma / pathology. Crohn Disease / complications. Ileal Neoplasms / pathology

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(PMID = 16116317.001).

[ISSN] 1078-0998

[Journal-full-title] Inflammatory bowel diseases

[ISO-abbreviation] Inflamm. Bowel Dis.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

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[Title] Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature.

Primary adenocarcinoma of the ileum is an uncommon gastrointestinal malignancy, the symptoms of which are often insidious in onset.

This case history highlights the previously unreported finding of ileal adenocarcinoma presenting with mucusuria, caused by local invasion of the bladder in a 44-year-old male.

A review of the literature is included to highlight the incidence, risk factors, clinical presentation, investigation, and current management of adenocarcinoma of the small bowel.

[MeSH-major] Adenocarcinoma / secondary. Ileal Neoplasms / pathology. Intestinal Fistula / diagnosis. Urinary Bladder Fistula / diagnosis. Urinary Bladder Neoplasms / secondary

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(PMID = 16119711.001).

[ISSN] 0020-8868

[Journal-full-title] International surgery

[ISO-abbreviation] Int Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

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[Title] Adenocarcinoma of the small bowel: a surgical dilemma.

Malignant tumors of the small intestine are among the rarest types of gastrointestinal cancers.

Due to their infrequent occurrence and the multitude of tumor types (viz, adenocarcinomas, carcinoids, sarcomas, and lymphomas), not much is known about their natural history and presentation, and there is often delay in the diagnosis.

Adenocarcinoma is the commonest histologic type of small bowel cancer.

In this article, a case of adenocarcinoma of the jejunum presenting as an abdominal lump is presented, along with a review of the literature.

[MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Jejunal Neoplasms / pathology. Jejunal Neoplasms / surgery

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(PMID = 19794274.001).

[ISSN] 1998-4049

[Journal-full-title] Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

[ISO-abbreviation] Saudi J Gastroenterol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Saudi Arabia

[Other-IDs] NLM/ PMC2981845

   

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[Title] Chemotherapeutic management of small bowel adenocarcinoma associated with Crohn's disease.

Four patients with metastatic primary small bowel adenocarcinoma associated with Crohn's disease were successfully treated with low dose combination chemotherapy consisting of 5-fluorouracil, leucovorin and irinotecan with or without gemcitabine.

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Crohn Disease / complications. Duodenal Neoplasms / drug therapy. Ileal Neoplasms / drug therapy. Jejunal Neoplasms / drug therapy

[MeSH-minor] Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Female. Humans. Intestine, Small / pathology. Leucovorin / administration & dosage. Male. Remission Induction. Survival Analysis

Genetic Alliance. consumer health - Crohn Disease.

MedlinePlus Health Information. consumer health - Crohn's Disease.

MedlinePlus Health Information. consumer health - Intestinal Cancer.

Hazardous Substances Data Bank. LEUCOVORIN .

NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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(PMID = 17127233.001).

[ISSN] 1120-009X

[Journal-full-title] Journal of chemotherapy (Florence, Italy)

[ISO-abbreviation] J Chemother

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

[Chemical-registry-number] 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; XT3Z54Z28A / Camptothecin

   

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[Title] Intussusception in adults: clinical characteristics, diagnosis and operative strategies.

AIM: To evaluate 20 adults with intussusception and to clarify the cause, clinical features, diagnosis, and management of this uncommon entity.

METHODS: A retrospective review of patients aged > 18 years with a diagnosis of intestinal intussusception between 2000 and 2008.

The majority of intussusceptions were in the small intestine (85%).

Among enteric intussusceptions, 14 were secondary to a benign process, and in one of these, the malignant cause was secondary to metastatic lung adenocarcinoma.

Treatment usually requires resection of the involved bowel segment.

Reduction can be attempted in small-bowel intussusception if the segment involved is viable or malignancy is not suspected; however, a more careful approach is recommended in colonic intussusception because of a significantly higher coexistence of malignancy.

[MeSH-major] Intussusception / diagnosis. Intussusception / surgery

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(PMID = 19399931.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] China

[Other-IDs] NLM/ PMC2675089