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1. Hisham RB, Thuaibah H, Gul YA: Mucinous adenocarcinoma of the rectum with breast and ocular metastases. Asian J Surg; 2006 Apr;29(2):95-7
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  • [Title] Mucinous adenocarcinoma of the rectum with breast and ocular metastases.
  • We present the case of a 32-year-old woman who, 10 months after abdominoperineal resection and total mesorectal excision for a locally advanced mucinous adenocarcinoma of the rectum, presented with local recurrence and metastases to the breast, spine, the left eye and orbit.
  • To the best of our knowledge, breast as well as ocular metastasis in a patient with mucinous adenocarcinoma of the rectum has never been reported and, therefore, needs to be documented.

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  • (PMID = 16644510.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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2. Tan KY, Ho KS, Lai JH, Lim JF, Ooi BS, Tang CL, Eu KW: Cutaneous and subcutaneous metastases of adenocarcinoma of the colon and rectum. Ann Acad Med Singapore; 2006 Aug;35(8):585-7
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  • [Title] Cutaneous and subcutaneous metastases of adenocarcinoma of the colon and rectum.
  • INTRODUCTION: The interesting topic of cutaneous and subcutaneous metastasis from rectal carcinoma is discussed using 3 cases.
  • CLINICAL PICTURE: The first case was a 70-year-old man with T3N2M0 rectal mucinous adenocarcinoma, who developed an inflammatory subcutaneous metastasis at the left scapula 2 years after anterior resection.
  • The second case was a 51-year-old man with T4N2M0 splenic flexure mucinous adenocarcinoma, who developed metastatic disease including a subcutaneous secondary to the back.
  • The third case was a 53-year-old woman who developed vulval recurrence 10 months after abdomino-perineal resection for a low T3N1M0 rectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Neoplasms, Connective Tissue / secondary. Rectal Neoplasms / pathology. Skin Neoplasms / secondary. Subcutaneous Tissue
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / secondary. Aged. Female. Humans. Male. Middle Aged

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  • (PMID = 17006588.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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3. Zamir N, Ahmed S, Akhtar J: Mucinous adenocarcinoma of colon. APSP J Case Rep; 2010 Jul;1(2):20

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  • [Title] Mucinous adenocarcinoma of colon.
  • Bleeding per rectum is a common complaint in pediatric age group and mostly relates to benign conditions.
  • We report two cases of mucinous adenocarcinoma of colon, one in a 9 years old male and other in a female of 12 years.
  • The boy presented with rectal bleeding and increasing constipation of more than three years duration.
  • He had mucinous adenocarcinoma (T3N0MX) of rectosigmoid region and underwent local complete resection of the tumor with colostomy.
  • The tumor was resected and biopsy reported as poorly differentiated mucinous adenocarcinoma with positive mesenteric nodes positive for tumor (T3N2MX).

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  • [Cites] J Postgrad Med. 1993 Oct-Dec;39(4):218-9 [7527858.001]
  • [Cites] J Pediatr Surg. 1999 Oct;34(10):1499-504 [10549756.001]
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  • (PMID = 22953263.001).
  • [ISSN] 2218-8185
  • [Journal-full-title] APSP journal of case reports
  • [ISO-abbreviation] APSP J Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Other-IDs] NLM/ PMC3417995
  • [Keywords] NOTNLM ; Bleeding per rectum / Child / Mucinous adenocarcinoma / Colorectum
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4. Koo VS, Lynn NN, Saxby MF: Radical exenteration surgery is curative in locally advance mucinous prostatic adenocarcinoma involving bladder and rectum. J Surg Case Rep; 2010;2010(4):6
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  • [Title] Radical exenteration surgery is curative in locally advance mucinous prostatic adenocarcinoma involving bladder and rectum.
  • The management of mucinous prostatic adenocarcinoma include hormonal treatment, radiotherapy and radical prostatectomy with variable long-term outcome.
  • We report a 59 year old man with advanced mucinous prostatic adenocarcinoma involving almost the entire bladder and had failed treatment with hormonal and radiotherapy, but subsequently underwent radical pelvic exenteration surgery that resulted in long-term cure.

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  • [Copyright] © JSCR.
  • (PMID = 24946309.001).
  • [ISSN] 2042-8812
  • [Journal-full-title] Journal of surgical case reports
  • [ISO-abbreviation] J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3649112
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5. Grillo-Ruggieri F, Mantello G, Berardi R, Cardinali M, Fenu F, Iovini G, Montisci M, Fabbietti L, Marmorale C, Guerrieri M, Saba V, Bearzi I, Mattioli R, Bonsignori M, Cascinu S: Mucinous rectal adenocarcinoma can be associated to tumor downstaging after preoperative chemoradiotherapy. Dis Colon Rectum; 2007 Oct;50(10):1594-603
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  • [Title] Mucinous rectal adenocarcinoma can be associated to tumor downstaging after preoperative chemoradiotherapy.
  • PURPOSE: The aim of this study was to evaluate downstaging as primary end point, and progression-free survival and overall survival as secondary end points, in rectal adenocarcinoma patients treated with preoperative chemoradiation.
  • METHODS: One hundred and thirty-six extraperitoneal adenocarcinoma patients (33 low rectum T2, 74 T3, 29 T4 [without sacral invasion], 25 with mucinous subtype) were treated with posterior pelvis preoperative radiotherapy (5040 cGy total dose, 180 cGy/fr, 5 fr/w, 10-15 MV linac X-rays) and concomitant 5-fluorouracil-based chemotherapy.
  • At multivariate analysis only histotype showed correlation with downstaging (hazard ratio = 0.350 and 0.138 - 0.885 95 percent confidence interval) because of the evidence for poor downstaging in mucinous subtype.
  • There were no significant differences in overall survival and progression-free survival between adenocarcinoma and mucinous subtype.
  • CONCLUSIONS: The main finding is that mucinous histology is associated with poor downstaging after preoperative chemoradiation but this poor response was not associated with worse outcome in this small study.
  • The good outcome for mucinous histology is at odds with other reports in the literature and requires further study.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / therapy. Rectal Neoplasms / pathology. Rectal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antimetabolites, Antineoplastic / therapeutic use. Chemotherapy, Adjuvant. Digestive System Surgical Procedures. Disease-Free Survival. Female. Fluorouracil / therapeutic use. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Survival Rate

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  • (PMID = 17846841.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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6. Onodera M, Nishigami T, Torii I, Sato A, Tao LH, Kataoka TR, Yoshikawa R, Tsujimura T: Comparison between colorectal low- and high-grade mucinous adenocarcinoma with MUC1 and MUC5AC. World J Gastrointest Oncol; 2009 Oct 15;1(1):69-73
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  • [Title] Comparison between colorectal low- and high-grade mucinous adenocarcinoma with MUC1 and MUC5AC.
  • AIM: To explore useful prognostic factors for mucinous adenocarcinoma (MAC) in the colon and rectum.
  • METHODS: MAC was divided into low- and high-grade types based on the degree of structural differentiation; low-grade MAC arisen from well to moderately differentiated adenocarcinoma and papillary carcinoma, and high-grade MAC from poorly differentiated adenocarcinoma and signet ring cell carcinoma.

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  • (PMID = 21160777.001).
  • [ISSN] 1948-5204
  • [Journal-full-title] World journal of gastrointestinal oncology
  • [ISO-abbreviation] World J Gastrointest Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999097
  • [Keywords] NOTNLM ; Colon / MUC1 / MUC5AC / Mucinous adenocarcinoma / Rectum
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7. Saad-Hossne R, Prado RG, Bakonyi Neto A, Marchezan MA: Peritoneal pseudomyxoma associated with synchronic malignant mucinous neoplasias of the cecum, appendix and rectum. Case report and review of the literature. Acta Cir Bras; 2007 Sep-Oct;22(5):407-11

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  • [Title] Peritoneal pseudomyxoma associated with synchronic malignant mucinous neoplasias of the cecum, appendix and rectum. Case report and review of the literature.
  • Peritoneal pseudomyxoma is a pathological condition that compromises the peritoneum, characterized by the production of large quantities of mucinous liquid, which progressively fills the peritoneal cavity, originating in general from mucinous appendicular or ovarian tumors.
  • We report a peritoneal pseudomyxoma associated with mucinous adenocarcinoma of the appendix synchronic with adenocarcinoma of the rectum in a 44 year old patient, where the initial diagnosis was rectal adenocarcinoma.
  • We focus the histological patterns of the lesions, diagnosis and the treatment, with revision of the literature.

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  • (PMID = 17923963.001).
  • [ISSN] 0102-8650
  • [Journal-full-title] Acta cirurgica brasileira
  • [ISO-abbreviation] Acta Cir Bras
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 33
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8. Venclauskas L, Saladzinskas Z, Tamelis A, Pranys D, Pavalkis D: Mucinous adenocarcinoma arising in an anorectal fistula. Medicina (Kaunas); 2009;45(4):286-90
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  • [Title] Mucinous adenocarcinoma arising in an anorectal fistula.
  • Mucinous adenocarcinoma in association with chronic anal fistula is a rare case in clinical practice.
  • The aim of this article was to report a rare case of anal gland mucinous adenocarcinoma in a patient who was treated in the Hospital of Kaunas University of Medicine.
  • Histological examination revealed mucinous adenocarcinoma, G2.
  • Colonoscopy investigation did not show any pathology in the rectum and bowels.
  • Endoanal ultrasound findings showed soft tissue induration at the site of anorectal fistula, no tumor in the rectum wall.
  • Histological examination after abdominoperineal resection revealed anal duct mucinous adenocarcinoma pT2 N0 L0 V0 R0, G2.
  • SUMMARY: Mucinous adenocarcinoma in anorectal fistula is a rare condition.
  • If surgical treatment for perineal abscess or anorectal fistula is not successful for a long time, mucinous adenocarcinoma should be suspected.
  • [MeSH-major] Adenocarcinoma, Mucinous. Anus Neoplasms. Rectal Fistula / complications
  • [MeSH-minor] Abscess / complications. Aged. Anal Canal / pathology. Humans. Male. Neoplasm Staging. Perineum

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  • (PMID = 19423959.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Lithuania
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9. Tanaka K: A case of metastases to the paranasal sinus from rectal mucinous adenocarcinoma. Int J Clin Oncol; 2006 Feb;11(1):64-5

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  • [Title] A case of metastases to the paranasal sinus from rectal mucinous adenocarcinoma.
  • We report a case of metastases to the paranasal sinus from rectal adenocarcinoma.
  • A 72-year-old woman, who had a history of therapy with rectal adenocarcinoma, came to our hospital for visual loss in her right eye.
  • From the surgical specimen, we found that the tumor was a metastasis of a previously managed rectal mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Paranasal Sinus Neoplasms / secondary. Rectal Neoplasms / pathology

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  • (PMID = 16508732.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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10. Ataseven H, Yüksel I, Arhan M, Köklü S, Başar O, Ertuğrul I, Saşmaz N: Mucinous carcinoma of the rectum in a boy presenting with bloody diarrhea. Clin Colorectal Cancer; 2009 Jul;8(3):169-71
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  • [Title] Mucinous carcinoma of the rectum in a boy presenting with bloody diarrhea.
  • Herein, we report a 15-year-old boy who presented with rectal bleeding, lower abdominal pain, and diarrhea.
  • A hard mass was palpated by digital rectal examination.
  • Histologic examination revealed a mucinous rectal adenocarcinoma.
  • He died 4 months after diagnosis.
  • This case highlights the need for awareness of colorectal carcinomas and their invasive nature in the differential diagnosis of rectal bleeding and diarrhea in adolescents.
  • [MeSH-major] Abdominal Pain / diagnosis. Adenocarcinoma, Mucinous / diagnosis. Diarrhea / diagnosis. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Fatal Outcome. Gastrointestinal Hemorrhage / diagnosis. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19632933.001).
  • [ISSN] 1938-0674
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Yamachika T, Nakanishi H, Yasui K, Ikehara Y, Niwa T, Wanibuchi H, Tatematsu M, Fukushima S: Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet-cell differentiation from liver metastasis. Pathol Int; 2005 Sep;55(9):550-7
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  • [Title] Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet-cell differentiation from liver metastasis.
  • Many human colorectal adenocarcinoma cell lines have been developed.
  • In the present study a novel colorectal adenocarcinoma cell line (designated as COLM-6) with predominant goblet-cell differentiation was established from the rectal mucinous adenocarcinoma of a Japanese woman.
  • COLM-6 cells form tumor with typical mucinous adenocarcinomatous appearance in nude mice.
  • These results indicate that COLM-6 cell line has unique characteristics and may provide a useful tool to study the mechanism of growth and differentiation of colonic epithelium as well as the biological behavior of colorectal mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Cell Line, Tumor / pathology. Colorectal Neoplasms / pathology. Goblet Cells / pathology. Liver Neoplasms / secondary
  • [MeSH-minor] Aged. Animals. Biomarkers, Tumor / metabolism. Cell Culture Techniques. Cell Proliferation. Cell Transformation, Neoplastic. Female. Fluorescent Antibody Technique, Indirect. Humans. Image Processing, Computer-Assisted. Male. Mice. Mice, Nude. Neoplasm Metastasis. Neoplasm Transplantation. Specific Pathogen-Free Organisms


12. King-Yin Lam A, Ong K, Ho YH: Colorectal mucinous adenocarcinoma: the clinicopathologic features and significance of p16 and p53 expression. Dis Colon Rectum; 2006 Sep;49(9):1275-83
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  • [Title] Colorectal mucinous adenocarcinoma: the clinicopathologic features and significance of p16 and p53 expression.
  • PURPOSE: This study was designed to examine the clinicopathologic features and p53 and p16 expressions in colorectal mucinous adenocarcinoma and colorectal signet-ring cell carcinoma.
  • METHODS: The clinicopathologic features of 36 patients with colorectal mucinous adenocarcinoma and colorectal signet-ring cell carcinoma were analyzed and compared with 228 patients with colorectal adenocarcinomas.
  • The p53 and p16 expressions in the colorectal mucinous adenocarcinoma and colorectal signet-ring cell carcinoma were studied by immunohistochemistry.
  • RESULTS: Colorectal mucinous adenocarcinoma and colorectal signet-ring cell carcinoma accounted for 14 percent of colorectal cancer.
  • Compared with the usual colorectal adenocarcinoma, colorectal mucinous adenocarcinoma and colorectal signet-ring cell carcinoma was found more often in proximal colorectum (P = 0.002), larger (P = 0.05), and in advanced stages (P = 0.018).
  • Forty-four percent (n = 16) of the colorectal mucinous adenocarcinoma and colorectal signet-ring cell carcinoma showed p53 expression.
  • All the patients with colorectal mucinous adenocarcinoma and colorectal signet-ring cell carcinoma with a positive family history of colorectal adenocarcinoma had tumors that showed p53 expression (P = 0.012).
  • The survival of these patients with colorectal mucinous adenocarcinoma and colorectal signet-ring cell carcinoma was poorer if the lesions were of advanced stages (P = 0.023) or with family history of colorectal cancer (P = 0.0015).
  • Also, patients with colorectal mucinous adenocarcinoma and colorectal signet-ring cell carcinoma that did not express p16 and p53 had better survival than other patients (P = 0.04).
  • CONCLUSIONS: Colorectal mucinous adenocarcinoma and colorectal signet-ring cell carcinoma had distinctive clinicopathologic features.
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Carcinoma, Signet Ring Cell / genetics. Colorectal Neoplasms / genetics. Gene Expression. Genes, p16. Genes, p53

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  • (PMID = 16912910.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p53
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13. Chaleoykitti B: Mucinous carcinoma of the colon and rectum in Phramongkutklao Hospital. J Med Assoc Thai; 2006 Jan;89(1):25-8

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  • [Title] Mucinous carcinoma of the colon and rectum in Phramongkutklao Hospital.
  • OBJECTIVE: The objective of the present study was to compare the clinicopathological significance between mucinous carcinoma and nonmucinous adenocarcinoma.
  • MATERIAL AND METHOD: Patients with carcinoma of the colon and rectum who had the first operation in the Department of Surgery, Phramongkutklao Hospital between 1999 and 2004 were included in the present study.
  • Patients were divided into two groups: nonmucinous group and mucinous group.
  • Forty four (10.7%) were mucinous carcinoma.
  • CONCLUSION: Colorectal mucinous carcinoma had no clinicopathological difference from nonmucinous adenocarcinoma of colon and rectum.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / pathology. Colonic Neoplasms / pathology. Rectal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 16583577.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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14. Xie L, Villeneuve PJ, Shaw A: Survival of patients diagnosed with either colorectal mucinous or non-mucinous adenocarcinoma: a population-based study in Canada. Int J Oncol; 2009 Apr;34(4):1109-15
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  • [Title] Survival of patients diagnosed with either colorectal mucinous or non-mucinous adenocarcinoma: a population-based study in Canada.
  • Previous studies have shown conflicting results on the prognosis of colorectal mucinous adenocarcinoma.
  • This study compared prognostic characteristics of patients diagnosed with mucinous and non-mucinous adenocarcinomas in a Canadian series.
  • Analyses were based on 165 colorectal mucinous and 1215 non-mucinous adenocarcinoma patients who were registered at the Ottawa Regional Cancer Centre from 1994 to 1997, with follow-up extending to December 31, 2001.
  • For colon, rectum and both combined, the distribution for age at diagnosis, stage and treatment of patients with mucinous adenocarcinoma was similar to that of non-mucinous patients (all p > or = 0.12).
  • Patients with mucinous histology had fewer well- or moderately-differentiated tumours than non-mucinous patients (all p < 0.01).
  • Overall, no statistically significant differences were noted in 5-year relative survival between mucinous and non-mucinous carcinoma for colon, rectum and their combination (p > or = 0.35 for each).
  • However, when the stages were considered separately, patients with stage III mucinous carcinoma had worse survival than patients with non-mucinous carcinoma for both sites.
  • Multivariate analysis of combined data for colon and rectal cancers indicated that independent significant prognostic factors were stage for mucinous, with age and grade as well as stage for non-mucinous carcinoma.
  • In conclusion, no significant differences in stage distribution and overall survival were found between mucinous and non-mucinous patients for colorectal cancer.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma, Mucinous / mortality. Colorectal Neoplasms / mortality
  • [MeSH-minor] Aged. Canada. Female. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Prognosis. Registries. Time Factors. Treatment Outcome

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  • (PMID = 19287969.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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15. Song W, Wu SJ, He YL, Cai SR, Zhang CH, Zhang XH, Zhan WH: Clinicopathologic features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma: experience at an institution in southern China. Chin Med J (Engl); 2009 Jul 5;122(13):1486-91
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  • [Title] Clinicopathologic features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma: experience at an institution in southern China.
  • BACKGROUND: Previous studies have shown conflicting results on the relation between clinicopathologic features and prognosis of patients with colorectal mucinous, signet-ring cell, or non-mucinous adenocarcinoma; only few such studies have been performed in China.
  • This retrospective study analyzed data from our department to investigate clinicopathologic characteristics, prognosis and possible correlations of three histologic types - colorectal mucinous, signet-ring cell, and non-mucinous adenocarcinoma, to clarify the bases for observed differences which may lead to development of targeted therapies.
  • METHODS: Of 2079 patients diagnosed with colorectal cancer between 1994 and 2007, 144 had mucinous, 25 had signet-ring cell, and 1837 had non-mucinous adenocarcinoma.
  • RESULTS: Mucinous and signet-ring cell adenocarcinomas were common in younger patients (P < 0.001).
  • Signet-ring cell tumors were more commonly found in the rectum than mucinous and non-mucinous adenocarcinoma (P < 0.001).
  • Mucinous and signet-ring cell tumors presented in a later stage in life more often than non-mucinous adenocarcinoma, with lymph node involvement, serosal infiltration, peritoneal dissemination, and adjacent organ invasion (P < 0.01).
  • Compared with patients with non-mucinous adenocarcinoma, patients with mucinous and signet-ring cell tumors who underwent potentially curative resections or stage II/III disease had poorer long-term overall survival.
  • CONCLUSIONS: Mucinous and signet-ring cell adenocarcinoma have unique carcinogenesis and similar biologic behavior.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Signet Ring Cell / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 19719934.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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16. Keese M, Back W, Dinter D, Gladisch R, Joos A, Palma P: Case report: late perianal mucinous adenocarcinoma after Crohn's disease proctectomy: an oncological rarity. World J Surg Oncol; 2005 Jun 29;3:42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report: late perianal mucinous adenocarcinoma after Crohn's disease proctectomy: an oncological rarity.
  • While carcinoma formation originating from ano-rectal fistulas is generally considered as a rare event there are different publications reporting on mucinous adenocarcinoma formation in association with a neovagina and rectovaginal fistulas.
  • To the best of our knowledge this is the first description of a perianal mucinous adenocarcinoma arising in a patient after Crohn's disease proctocolectomy.
  • CASE PRESENTATION: We report the case of a 50-year old female with a mucinous adenocarcinoma forming in the perineum eleven years after proctocolectomy for Crohn's disease.
  • Histological examination revealed a mucinous adenocarcinoma.
  • CONCLUSION: Mucinous adenocarcinoma formation is a rare complication of Crohn's disease and so far unreported after proctocolectomy.

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  • (PMID = 15987512.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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17. Itah R, Werbin N, Skornick Y, Greenberg R: [Anal mucinous adenocarcinoma arising in long standing fistula-in-ano]. Harefuah; 2008 Feb;147(2):117-9, 183
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anal mucinous adenocarcinoma arising in long standing fistula-in-ano].
  • Perianal mucinous adenocarcinoma is an unusual but well described malignancy constituting approximately 3 to 11% of all anal carcinoma.
  • The pathology is thought to develop from one of three types, the distal part of the rectum, the mucin-secreting columnar epithelium of the anal glands, and from chronic fistula-in-ano.
  • Mucinous adenocarcinoma of the anus supervening on a long-standing chronic anal fistula is an extremely rare disease with less then 150 cases reported in the literature, mainly single patient reports.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Anus Neoplasms / etiology. Rectal Fistula / complications

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  • (PMID = 18357666.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Israel
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18. Sandiford N, Prussia PR, Chiappa A, Zbar AP: Synchronous mucinous adenocarcinoma of the rectosigmoid seeding onto a pre-existing anal fistula. Int Semin Surg Oncol; 2006;3:25

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous mucinous adenocarcinoma of the rectosigmoid seeding onto a pre-existing anal fistula.
  • Carcinoma within a long-standing fistula-in-ano is rare and may be defined by specific neoplastic involvement of the fistulous track in the absence of rectal mucosal carcinoma.
  • The presence of a carcinoma of mucinous histology occurring synchronously in the perianal region and the colon is exceptionally rare.
  • A 72-year-old man with a 2 months history of dark red rectal bleeding and mucus per rectum with alternating constipation and diarrhoea, was observed.
  • Histology showed an adenocarcinoma with a clear resection margins.

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  • (PMID = 16961916.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1592294
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19. Chen CF, Huang CJ, Kang WY, Hsieh JS: Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4). World J Surg Oncol; 2008;6:118
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4).
  • BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare condition characterized by mucinous tumors, disseminated intra-peritoneal implants, and mucinous ascites.
  • So far its diagnosis remains challenging to most clinicians.
  • Paracentesis showed the appearance of sticky mucinous ascites.
  • There was a lot of mucinous ascites, one appendiceal tumor and multiple peritoneal implants disseminated from the subphrenic space to the recto-vesicle pouch.
  • Pseudomyxoma Peritonei caused by mucinous adenocarcinoma of appendiceal origin, was confirmed by histopathology.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / drug therapy. Peritoneal Neoplasms / drug therapy. Pseudomyxoma Peritonei / drug therapy

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  • (PMID = 19014441.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2615010
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20. Arfaoui Toumi A, Kriaa Ben Mahmoud L, Khiari M, Lahmer A, Gharbi L, Dhraïef M, Khalfallah T, Regaya Mzabi S, Bouraoui S: [Epidemiological study, pathologic evaluation and prognostic factors of colorectal mucinous vs non-mucinous adenocarcinoma (a series of 196 patients)]. Tunis Med; 2010 Jan;88(1):12-7
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  • [Title] [Epidemiological study, pathologic evaluation and prognostic factors of colorectal mucinous vs non-mucinous adenocarcinoma (a series of 196 patients)].
  • BACKGROUND: Colorectal carcinoma is one of the main causes of cancer death in the worldwide with a decrease survival rate in relationship with a later diagnosis of advanced disease.
  • Age at diagnosis, mode of presentation, sex, tumour location, macroscopic and histological features, TNM and Astler Coller stage were assessed and evaluated.
  • The poorer degree of differentiation and mucinous subtype are correlated with an advanced stage.
  • Furthermore, immunohistochemical analysis of galectin-3 showed a significant difference between mucinous and non mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / pathology. Biomarkers, Tumor / analysis. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / pathology. Galectin 3 / analysis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Colon, Sigmoid / pathology. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Prognosis. Prospective Studies. Rectum / pathology. Retrospective Studies. Risk Factors. Survival Analysis. Tunisia / epidemiology

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  • (PMID = 20415207.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Tunisia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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21. Kang H, O'Connell JB, Maggard MA, Sack J, Ko CY: A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum; 2005 Jun;48(6):1161-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum.
  • PURPOSE: Most studies examining mucinous or signet-ring cell colorectal cancers are single institution reports.
  • This study used a national cancer registry to analyze the epidemiology and survival outcomes of these two subtypes of colorectal cancer compared with adenocarcinoma tumors.
  • METHODS: All patients diagnosed with mucinous (n = 16,991), signet-ring cell (n = 1,522), or adenocarcinoma (n = 146,115) colorectal cancer in the Surveillance, Epidemiology, and End Results database (1991-2000) were evaluated.
  • RESULTS: Mucinous were slightly more common in females (53.4 percent).
  • Incidence rates per 100,000 persons were: mucinous, 5.5; signet-ring cell, 0.6; and adenocarcinoma 46.6.
  • The annual percent change during ten years was stable for mucinous, increased for signet-ring cell (4.8 percent; P < 0.05), and decreased for adenocarcinoma (-1.1 percent; P < 0.05).
  • Fewer mucinous (18 percent) and signet-ring cell (21 percent) tumors were located in the rectum compared with adenocarcinoma (29 percent).
  • Signet-ring cell presented at later stage (III/IV, 80.9 percent) more often than mucinous (52.8 percent) and adenocarcinoma (49.5 percent), and also had worse tumor grade (high grade: signet-ring cell, 73.5 percent; mucinous, 20.9 percent; adenocarcinoma, 17.5 percent).
  • Relative five-year survival was worse for signet-ring cell than mucinous or adenocarcinoma.
  • Although the incidence of colorectal adenocarcinoma is decreasing in the United States, mucinous and signet-ring cell subtypes are stable and increasing, respectively.
  • Importantly, it seems that the signet-ring cell subtype has worse outcomes, whereas survival rates for mucinous tumors are similar to adenocarcinomas.
  • [MeSH-major] Adenocarcinoma, Mucinous / epidemiology. Carcinoma, Signet Ring Cell / epidemiology. Colonic Neoplasms / epidemiology. Rectal Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. SEER Program. Survival Rate. Treatment Outcome. United States / epidemiology

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  • (PMID = 15868237.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. Kim DJ, Kim JH, Lim JS, Yu JS, Chung JJ, Kim MJ, Kim KW: Restaging of Rectal Cancer with MR Imaging after Concurrent Chemotherapy and Radiation Therapy. Radiographics; 2010 Mar;30(2):503-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Restaging of Rectal Cancer with MR Imaging after Concurrent Chemotherapy and Radiation Therapy.
  • In patients with rectal cancer who have received concurrent chemotherapy and radiation therapy (CCRT) before surgery, magnetic resonance (MR) imaging has low accuracy in prediction of the pathologic stage owing to overstaging or understaging.
  • Preoperative diagnosis with MR imaging of histologic variants of rectal adenocarcinoma, especially mucinous adenocarcinoma, is important because these variants tend to have a poor response to CCRT.
  • Awareness of post-CCRT changes helps radiologists achieve appropriate restaging of irradiated rectal cancer with MR imaging and can lead to a reduction in understaging or overstaging.
  • [MeSH-major] Chemotherapy, Adjuvant. Magnetic Resonance Imaging / methods. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / prevention & control. Radiotherapy, Adjuvant. Rectal Neoplasms / diagnosis. Rectal Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Humans. Neoplasm Staging. Treatment Outcome

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  • (PMID = 20228331.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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23. Leal RF, Ayrizono ML, Coy CS, Fagundes JJ, Góes JR: Mucinous adenocarcinoma derived from chronic perianal fistulas: report of a case and review of the literature. Tech Coloproctol; 2007 Jun;11(2):155-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous adenocarcinoma derived from chronic perianal fistulas: report of a case and review of the literature.
  • However, their evolution into adenocarcinoma is rare.
  • Diagnosis was confirmed by magnetic resonance imaging (MRI).
  • Histopathological sections indicated extramucosal mucinous adenocarcinoma.
  • The patient underwent abdominal perineal excision of the rectum without neoadjuvant or adjuvant therapy, and had a good postoperative outcome.
  • [MeSH-major] Adenocarcinoma, Mucinous / nursing. Anus Neoplasms / pathology. Rectal Fistula / pathology

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  • (PMID = 17510737.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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24. Petrou A, Papalambros A, Katsoulas N, Bramis K, Evangelou K, Felekouras E: Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case. World J Surg Oncol; 2010;8:49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case.
  • INTRODUCTION: Mucinous adenocarcinoma is a rare neoplasm of the gastrointestinal tract and one of the three major histological subtypes of the primary appendiceal adenocarcinoma.
  • The most common type of presentation is that of acute appendicitis and the diagnosis is usually occurred after appendectomy.
  • The accurate preoperative diagnosis and management of the above condition represents a real challenge when uncommon anatomic anomalies such intestinal malrotation and situs inversus take place.
  • These findings reached to the diagnosis of acute appendicitis with situs inversus and a standard appendicectomy was performed.
  • Pathologic evaluation established primary mucinous adenocarcinoma of the appendix and three months afterwards the patient underwent a subsequent extended left hemicolectomy.
  • CONCLUSION: In conclusion, the occurrence of primary appendiceal mucinous adenocarcinoma along with situs inversus, definitely accounts as a unique clinical case.
  • Even synchronous manifestation of primary mucinous adenocarcinoma of the appendix and situs inversus totalis represents an unusual anatomo-pathological entity, all physicians should be familiar having the knowledge to make an appropriate and accurate diagnosis that will lead to prompt and correct treatment.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Appendiceal Neoplasms / complications. Situs Inversus / complications

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  • (PMID = 20525349.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2894825
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25. Vang R, Gown AM, Wu LS, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM: Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Mod Pathol; 2006 Nov;19(11):1421-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7.
  • Recent studies have demonstrated conflicting results regarding the value of CDX2 for distinguishing primary ovarian mucinous tumors from metastatic mucinous carcinomas in the ovary.
  • Utility of coordinate expression of cytokeratins 7 and 20 is restricted to distinction of ovarian mucinous tumors from lower gastrointestinal tract metastases and data comparing coordinate expression of all three markers is limited.
  • Immunohistochemical studies were performed to compare expression of CDX2 and cytokeratin 20, both markers of intestinal differentiation, in conjunction with coordinate expression of cytokeratin 7, in 90 mucinous tumors involving the ovary: 42 primary ovarian mucinous tumors (31 atypical proliferative (borderline) mucinous tumors (gastrointestinal type), 11 mucinous carcinomas) and 48 metastatic mucinous carcinomas of upper (pancreaticobiliary tract: 14; stomach: five) and lower (colon and rectum: 25; appendix: four) gastrointestinal tract origin.
  • CDX2 provided some advantage over cytokeratin 20 for distinguishing primary ovarian mucinous tumors from metastases of upper but not lower gastrointestinal tract origin; however, the advantage in the former was limited due to the occurrence of shared coordinate expression profiles in both tumor types.
  • [MeSH-major] Adenocarcinoma, Mucinous / chemistry. Biomarkers, Tumor / analysis. Gastrointestinal Neoplasms / chemistry. Homeodomain Proteins / analysis. Keratin-7 / analysis. Ovarian Neoplasms / chemistry
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-20 / analysis

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  • (PMID = 16980943.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7
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26. Sayles M, Courtney E, Younis F, O'Donovan M, Ibrahim A, Fearnhead NS: Appendiceal mucinous adenocarcinoma presenting as an enterocutaneous fistula in an incisional hernia. BMJ Case Rep; 2010;2010
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  • [Title] Appendiceal mucinous adenocarcinoma presenting as an enterocutaneous fistula in an incisional hernia.
  • At laparoscopy, the appendix was adherent to the hernia sac with mucinous material at the superficial orifice of the fistula site but not in the peritoneal cavity.
  • Histological evaluation confirmed a well-to-moderately differentiated mucinous adenocarcinoma arising on a background of dysplastic villous adenoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis. Bone Transplantation. Hernia, Abdominal / diagnosis. Ilium / surgery. Intestinal Fistula / diagnosis. Postoperative Complications / diagnosis. Tissue and Organ Harvesting
  • [MeSH-minor] Abdominal Abscess / diagnosis. Aged. Appendectomy. Colectomy. Female. Humans. Laparoscopy. Lymph Node Excision. Neoplasm Staging. Reoperation

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  • (PMID = 22789695.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3038038
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27. Djuranovic SP, Spuran MM, Kovacevic NV, Ugljesic MB, Kecmanovic DM, Micev MT: Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver: report of a case. World J Gastroenterol; 2006 Mar 28;12(12):1975-7
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  • [Title] Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver: report of a case.
  • Mucinous cystadenoma of the appendix is a rare condition and represents one of the three entities with the common name mucocele of the appendix.
  • Histopathologically mucocele is divided into three groups: focal or diffuse mucosal hyperplasia, mucinous cystadenoma and mucinous cystadenocarcinoma.
  • This condition is often associated with other neoplasia, especially adenocarcinoma of the colon and ovaries.
  • He had a big cystadenoma of the appendix associated with adenocarcinoma of the colon and hepatocellular carcinoma of the liver.
  • According to this, we stress the need of accurate preoperative diagnosis and intraoperative exploration of the whole abdomen in these patients.
  • [MeSH-major] Adenocarcinoma / complications. Appendiceal Neoplasms / complications. Carcinoma, Hepatocellular / complications. Cystadenoma, Mucinous / complications. Liver Neoplasms / complications. Sigmoid Neoplasms / complications

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  • (PMID = 16610012.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087531
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28. Melis M, Hernandez J, Siegel EM, McLoughlin JM, Ly QP, Nair RM, Lewis JM, Jensen EH, Alvarado MD, Coppola D, Eschrich S, Bloom GC, Yeatman TJ, Shibata D: Gene expression profiling of colorectal mucinous adenocarcinomas. Dis Colon Rectum; 2010 Jun;53(6):936-43
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  • [Title] Gene expression profiling of colorectal mucinous adenocarcinomas.
  • PURPOSE: Although mucinous adenocarcinomas represent 6% to 19% of all colorectal adenocarcinomas, little is known about the genome-wide alterations associated with this malignancy.
  • We have sought to characterize both the gene expression profiles of mucinous adenocarcinomas and their clinicopathologic features.
  • RESULTS: Twenty (11.7%) mucinous adenocarcinomas and 151 (89.3%) nonmucinous adenocarcinomas were identified.
  • Mucinous adenocarcinomas were more likely to be diagnosed with lymph node (LN) metastases (75% vs 51%, P = .04) and at a more advanced stage (85% vs 54%, P = .006) but long-term survival (5-y survival 58.9% vs 58.7%, P = NS) was similar.
  • Mucinous adenocarcinomas displayed 182 upregulated and 135 downregulated genes.
  • DISCUSSION: Using gene expression profiling of mucinous adenocarcinomas, we have identified the differential upregulation of genes involved in differentiation and mucin metabolism, as well as specific biologic pathways.
  • These findings suggest that mucinous adenocarcinomas represent a genetically distinct variant of colorectal adencarcinoma and have implications for the development of targeted therapies.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma, Mucinous / genetics. Colorectal Neoplasms / genetics. Gene Expression Profiling

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  • (PMID = 20485009.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AQP3 protein, human; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 158801-98-0 / Aquaporin 3
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29. Negri FV, Wotherspoon A, Cunningham D, Norman AR, Chong G, Ross PJ: Mucinous histology predicts for reduced fluorouracil responsiveness and survival in advanced colorectal cancer. Ann Oncol; 2005 Aug;16(8):1305-10
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  • [Title] Mucinous histology predicts for reduced fluorouracil responsiveness and survival in advanced colorectal cancer.
  • BACKGROUND: Mucinous carcinoma of the colon and rectum (mucinous CRC) is a histological subtype of colorectal adenocarcinoma for which there is little data on chemotherapy responsiveness.
  • The purpose of this study was to investigate specifically the efficacy of fluorouracil-based first-line chemotherapy in patients with advanced mucinous CRC.
  • PATIENTS AND METHODS: All patients with advanced mucinous CRC enrolled in three prospective randomized trials evaluating infused 5-fluorouracil as first-line treatment were compared with patients with non-mucinous subtypes enrolled in the same trials in a case-control study.
  • Median OS for the mucinous CRC patients was 11.8 months (95% CI, 8.87-14.8) compared with 17.9 months (95% CI, 13.38-22.39) in the control group (univariate analysis, P=0.056); after correcting for significant prognostic factors by multivariate Cox regression analysis, P=0.0372 and hazard ratio (HR)=1.497 (1.02-2.19).
  • CONCLUSION: Patients with advanced mucinous CRC have a poorer response to fluorouracil-based first-line chemotherapy and reduced survival compared with patients with non-mucinous CRC.

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  • (PMID = 15857840.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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30. Kazama Y, Watanabe T, Kanazawa T, Tada T, Tanaka J, Nagawa H: Mucinous carcinomas of the colon and rectum show higher rates of microsatellite instability and lower rates of chromosomal instability: a study matched for T classification and tumor location. Cancer; 2005 May 15;103(10):2023-9

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  • [Title] Mucinous carcinomas of the colon and rectum show higher rates of microsatellite instability and lower rates of chromosomal instability: a study matched for T classification and tumor location.
  • BACKGROUND: The clinicopathologic significance of mucinous carcinomas (Muc) of the colon and rectum has been widely discussed, but there have been few studies on Muc regarding genetic and epigenetic alterations.
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Chromosomal Instability / genetics. Colonic Neoplasms / genetics. Microsatellite Repeats / genetics. Rectal Neoplasms / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Base Pair Mismatch / genetics. Carrier Proteins. Case-Control Studies. Chromosomes, Human, Pair 17 / genetics. Chromosomes, Human, Pair 18 / genetics. Chromosomes, Human, Pair 2 / genetics. Chromosomes, Human, Pair 5 / genetics. Epigenesis, Genetic / genetics. Female. Humans. Loss of Heterozygosity / genetics. Male. Methylation. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Staging. Nuclear Proteins / genetics. Promoter Regions, Genetic / genetics

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  • (PMID = 15812832.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins
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31. Glasgow SC, Yu J, Carvalho LP, Shannon WD, Fleshman JW, McLeod HL: Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. Br J Cancer; 2005 Jan 31;92(2):259-64
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  • [Title] Unfavourable expression of pharmacologic markers in mucinous colorectal cancer.
  • Patients with mucinous colorectal cancer generally have worse prognoses than those with the nonmucinous variety.
  • In all, 21 patients with mucinous and 30 with nonmucinous Dukes C colorectal cancer were reviewed for demographic data and outcome.
  • Mucinous tumours significantly overexpressed both TYMS and GSTP1 relative to nonmucinous tumours and patient-matched normal mucosa.
  • Among patients receiving 5-FU, those with mucinous tumours experienced shorter disease-free survival (DFS) than those with nonmucinous tumours (median DFS 13.8 vs 46.5 months, P=0.053).
  • Mucinous colorectal cancer overexpresses markers of resistance to 5-FU and oxaliplatin.
  • Likewise, DFS may be decreased in patients with mucinous tumours who receive 5-FU.

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  • (PMID = 15655543.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA091842; United States / NIGMS NIH HHS / GM / U01 GM063340; United States / NIGMS NIH HHS / GM / U01 GM63340
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA Primers; 0 / Organoplatinum Compounds; 0 / RNA, Messenger; 04ZR38536J / oxaliplatin; 7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
  • [Other-IDs] NLM/ PMC2361854
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32. Alexiou K, Sikalias N, Demonakou M, Mylona SC, Triantafyllis V, Kalogirou A, Antsaklis G: Mucinous adenocarcinoma of the appendix presenting with atypical symptomatology and presence of pseudomyxoma peritonei: a case report. Cases J; 2009;2:9089

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  • [Title] Mucinous adenocarcinoma of the appendix presenting with atypical symptomatology and presence of pseudomyxoma peritonei: a case report.
  • CASE PRESENTATION: A female patient with mucous adenocarcinoma of the appendix, which primarily presented as atypical abdominal pain.
  • Diagnosis of the disease was made after appendicectomy and histopathological analysis of the specimen.
  • Although at present they are a well studied pathologic entity, the crucial issue of their preoperative diagnosis remains unsolved.

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  • (PMID = 20062726.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803886
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33. Kawahara K, Mishima H, Nakamura S: Heterotopic respiratory mucosa in the rectum: a first case report. Virchows Arch; 2007 Nov;451(5):977-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Heterotopic respiratory mucosa in the rectum: a first case report.
  • Colonoscopic examination showed Borrmann type 1 rectal carcinoma in the lower rectum, which was later demonstrated to be mucinous adenocarcinoma of Dukes' class A.
  • The pathological diagnosis was heterotopic respiratory mucosa (HRM) arising in the rectum.
  • To our knowledge, this is the first reported case of HRM in the rectum.
  • [MeSH-major] Choristoma. Rectal Diseases. Respiratory Mucosa
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Female. Humans. Intestinal Polyps / pathology. Middle Aged. Rectal Neoplasms / pathology

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  • (PMID = 17899182.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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34. Ciocca V, Bombonati A, Palazzo JP, Schulz S, Waldman SA: Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms. Histopathology; 2009 Aug;55(2):182-8
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  • [Title] Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms.
  • AIMS: The aim was to assess the value of GCC in distinguishing primary ovarian mucinous neoplasms from metastatic mucinous adenocarcinomas with ovarian involvement.
  • Guanylyl cyclase C (GCC) is a brush border membrane receptor for the endogenous peptides guanylin and uroguanylin, and the homologous diarrhoeagenic bacterial heat-stable enterotoxins that is selectively expressed by epithelial cells from the duodenum to the rectum, but not by normal epithelia of the stomach or oesophagus, or normal extramucosal cells in humans.
  • METHODS AND RESULTS: Fifty ovarian tumours: 27 primary ovarian mucinous neoplasms (seven cystadenomas, 10 borderline tumours and 10 cystadenocarcinomas) and 23 metastatic mucinous adenocarcinomas with ovarian involvement [13 colorectal adenocarcinomas, four gastric adenocarcinomas, six appendiceal mucinous tumours (four adenocarcinomas, one with neuroendocrine features, and two appendiceal mucinous cystadenomas)] were studied.
  • For primary ovarian mucinous neoplasms, 25 of 27 were negative for GCC.
  • Twelve of 13 cases of colorectal adenocarcinoma (except for one neuroendocrine adenocarcinoma) were positive for GCC.
  • Three of four appendiceal mucinous adenocarcinomas were positive for GCC in both the primary and metastatic tumours (except for one neuroendocrine adenocarcinoma).
  • Two of two appendiceal mucinous cystadenomas were positive for GCC.
  • Of four cases of gastric adenocarcinoma with ovarian involvement, only one (primary tumour) exhibited focal GCC staining.
  • CONCLUSIONS: GCC is a useful marker for differentiating between primary and secondary ovarian mucinous neoplasms.

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  • (PMID = 19694825.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA75123; United States / NCI NIH HHS / CA / R01 CA075123-04; United States / NCI NIH HHS / CA / R01 CA095026-04; United States / NCI NIH HHS / CA / R01 CA095026; United States / NCI NIH HHS / CA / CA95026; United States / NCI NIH HHS / CA / R01 CA075123
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Peptide; EC 4.6.1.2 / Guanylate Cyclase; EC 4.6.1.2 / Receptors, Guanylate Cyclase-Coupled; EC 4.6.1.2 / enterotoxin receptor
  • [Other-IDs] NLM/ NIHMS309367; NLM/ PMC3140017
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35. Lee JS, Moon W, Park SJ, Park MI, Kim KJ, Jang LL, Park MJ, Chun BK: Triple synchronous primary cancers of rectum, thyroid, and uterine cervix detected during the workup for hematochezia. Intern Med; 2010;49(16):1745-7
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  • [Title] Triple synchronous primary cancers of rectum, thyroid, and uterine cervix detected during the workup for hematochezia.
  • Multiple primary cancers are defined as multiple occurrences of malignant neoplasm of different histologic origin in the same individual.
  • Herein, we report an extremely rare case of synchronous triple primary cancers of the rectum, thyroid gland and uterine cervix; all were detected during the work-up for hematochezia.
  • [MeSH-major] Gastrointestinal Hemorrhage / diagnosis. Neoplasms, Multiple Primary / diagnosis. Rectal Neoplasms / diagnosis. Thyroid Neoplasms / diagnosis. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma, Mucinous / complications. Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / diagnosis. Female. Follow-Up Studies. Humans. Middle Aged


36. Baumgaertner I, Corcos O, Couvelard A, Sauvanet A, Rebours V, Vullierme MP, Hentic O, Hammel P, Lévy P, Ruszniewski P: Prevalence of extrapancreatic cancers in patients with histologically proven intraductal papillary mucinous neoplasms of the pancreas: a case-control study. Am J Gastroenterol; 2008 Nov;103(11):2878-82
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  • [Title] Prevalence of extrapancreatic cancers in patients with histologically proven intraductal papillary mucinous neoplasms of the pancreas: a case-control study.
  • BACKGROUND: Some studies have suggested that intraductal papillary mucinous neoplasms (IPMN) of the pancreas could be associated with extrapancreatic cancers (EPC)--especially from gastric and colorectal origin.
  • The most frequent cancers in patients with IPMN and controls were: breast (30% in each group), prostate (10% and 13%, respectively, not significant [NS]), and colon/rectum (10 and 6%, respectively, NS).
  • Most of the EPCs precede the diagnosis of IPMN.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Neoplasms, Multiple Primary / diagnosis. Pancreatic Neoplasms / pathology

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  • (PMID = 18853975.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Semino-Mora C, Liu H, McAvoy T, Nieroda C, Studeman K, Sardi A, Dubois A: Pseudomyxoma peritonei: is disease progression related to microbial agents? A study of bacteria, MUC2 AND MUC5AC expression in disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. Ann Surg Oncol; 2008 May;15(5):1414-23
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  • [Title] Pseudomyxoma peritonei: is disease progression related to microbial agents? A study of bacteria, MUC2 AND MUC5AC expression in disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis.
  • BACKGROUND AND AIMS: Pseudomyxoma peritonei (PMP) is characterized by peritoneal tumors arising from a perforated appendiceal adenoma or adenocarcinoma, but associated entry of enteric bacteria in the peritoneum has not been considered as a cofactor.
  • METHODS: In situ hybridization was performed on resection specimens from five control subjects with noninflamed, nonperforated, non-neoplastic appendix and 16 patients with PMP [six with disseminated peritoneal adenomucinosis (DPAM) and 10 with peritoneal mucinous carcinomatosis (PMCA)].
  • CONCLUSIONS: Multiple enteric bacteria are present in PMP, and bacterial density and MUC2 expression is highest in the malignant form of PMP.
  • Based on these observations, we propose that the bacteria observed in PMP may play a role in the mucinous ascites and perhaps promote carcinogenesis.

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  • (PMID = 18299935.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA082312-08; United States / NCI NIH HHS / CA / R01 CA082312; United States / NCI NIH HHS / CA / CA82312; United States / NCI NIH HHS / CA / R01 CA082312-08
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA Probes; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucins; 0 / RNA Probes
  • [Other-IDs] NLM/ NIHMS72052; NLM/ PMC2570966
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38. Winder T, Lenz HJ: Mucinous adenocarcinomas with intra-abdominal dissemination: a review of current therapy. Oncologist; 2010;15(8):836-44
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  • [Title] Mucinous adenocarcinomas with intra-abdominal dissemination: a review of current therapy.
  • The present review provides an update of the most recent data on the current therapy for pseudomyxoma peritonei (PMP) and mucinous colorectal adenocarcinoma (MCA) with metastatic disease confined to the peritoneum.
  • [MeSH-major] Adenocarcinoma, Mucinous / therapy. Peritoneal Neoplasms / therapy. Pseudomyxoma Peritonei / therapy

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  • (PMID = 20656916.001).
  • [ISSN] 1549-490X
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3228029
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39. Catalano V, Loupakis F, Graziano F, Torresi U, Bisonni R, Mari D, Fornaro L, Baldelli AM, Giordani P, Rossi D, Alessandroni P, Giustini L, Silva RR, Falcone A, D'Emidio S, Fedeli SL: Mucinous histology predicts for poor response rate and overall survival of patients with colorectal cancer and treated with first-line oxaliplatin- and/or irinotecan-based chemotherapy. Br J Cancer; 2009 Mar 24;100(6):881-7
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  • [Title] Mucinous histology predicts for poor response rate and overall survival of patients with colorectal cancer and treated with first-line oxaliplatin- and/or irinotecan-based chemotherapy.
  • The objective of this study was to investigate the efficacy of first-line chemotherapy containing irinotecan and/or oxaliplatin in patients with advanced mucinous colorectal cancer.
  • The population included 255 patients, of whom 49 (19%) had mucinous and 206 (81%) had non-mucinous colorectal cancer.
  • The overall response rates for mucinous and non-mucinous tumours were 18.4 (95% CI, 7.5-29.2%) and 49% (95% CI, 42.2-55.8%), respectively (P=0.0002).
  • After a median follow-up of 45 months, median overall survival for the mucinous patients was 14.0 months compared with 23.4 months for the non-mucinous group (hazard ratio (HR), 1.74; CI 95%, 1.27-3.31; P=0.0034).
  • After adjustment for significant features by multivariate Cox regression analysis, mucinous histology was associated with poor overall survival (HR, 1.593, 95% CI, 1.05-2.40; P=0.0267), together with performance status ECOG 2, number of metastatic sites > or =2, and peritoneal metastases.
  • This retrospective analysis shows that patients with mucinous colorectal cancer have poor responsiveness to oxaliplatin/irinotecan-based first-line combination chemotherapy and an unfavourable prognosis compared with non-mucinous colorectal cancer patients.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Antineoplastic Agents / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Colorectal Neoplasms / drug therapy. Organoplatinum Compounds / administration & dosage

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  • (PMID = 19259089.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
  • [Other-IDs] NLM/ PMC2661784
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40. Min BS, Kim NK, Ko YT, Baek SH, Lee KY, Sohn SK, Cho CH, Kang DR: Clinicopathological features of signet-ring cell carcinoma of the colon and rectum: a case-matched study. Hepatogastroenterology; 2009 Jul-Aug;56(93):984-8
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  • [Title] Clinicopathological features of signet-ring cell carcinoma of the colon and rectum: a case-matched study.
  • BACKGROUND/AIMS: Primary colorectal signet-ring cell carcinoma (SRC) is a rare type of mucin-containing adenocarcinoma and little information exists about its clinicopathological features.
  • METHODS: The clinicopathological features of 27 patients with primary colorectal SRC were compared with non-signet-ring cell mucinous carcinoma (MC) and non-mucinous adenocarcinoma (NMC).
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Signet Ring Cell / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Case-Control Studies. Chi-Square Distribution. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Survival Rate

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  • (PMID = 19760925.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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41. Ota H, Yamazaki K, Endoh W, Hojo S, Fukunaga H, Yoshioka S, Okada Y, Okamoto S, Ueda N, Maeura Y: Adenocarcinoma arising below an ileoanal anastomosis after restorative proctocolectomy for ulcerative colitis: report of a case. Surg Today; 2007;37(7):596-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma arising below an ileoanal anastomosis after restorative proctocolectomy for ulcerative colitis: report of a case.
  • We report a case of adenocarcinoma developing in remnant rectal mucosa below a hand-sewn ileal pouch-anal anastomosis (IPAA) after restorative proctocolectomy for ulcerative colitis (UC).
  • About 7 years later, a follow-up endoscopy showed a flat elevated malignant lesion, 2 cm in diameter, below the ileoanal anastomosis.
  • Histopathological examination of the resected specimen confirmed the presence of a well-differentiated adenocarcinoma but there were no metastatic lymph nodes.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Anus Neoplasms / etiology. Colitis, Ulcerative / complications. Ileum / surgery. Proctocolectomy, Restorative / adverse effects. Rectum / surgery

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  • (PMID = 17593481.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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42. Pedersen ME, Rahr HB, Fenger C, Qvist N: Adenocarcinoma arising from the rectal stump eleven years after excision of an ileal J-pouch in a patient with ulcerative colitis: report of a case. Dis Colon Rectum; 2008 Jul;51(7):1146-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma arising from the rectal stump eleven years after excision of an ileal J-pouch in a patient with ulcerative colitis: report of a case.
  • We report a case of adenocarcinoma in the anal canal 11 years after removal of a failed ileal J-pouch.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Colitis, Ulcerative / surgery. Colonic Pouches / pathology. Rectal Neoplasms / etiology
  • [MeSH-minor] Anastomosis, Surgical. Biopsy. Diagnosis, Differential. Fatal Outcome. Follow-Up Studies. Humans. Ileostomy. Male. Middle Aged. Proctocolectomy, Restorative / methods. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 18437493.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Puppa G, Maisonneuve P, Sonzogni A, Masullo M, Chiappa A, Valerio M, Zampino MG, Franceschetti I, Capelli P, Chilosi M, Menestrina F, Viale G, Pelosi G: Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma. Br J Cancer; 2007 Apr 10;96(7):1118-26
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  • [Title] Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma.
  • In this study, we investigated the expression of fascin in 228 advanced colonic adenocarcinoma patients with a long follow-up.
  • Fascin correlated significantly with sex, tumour grade and stage, mucinous differentiation, number of metastatic lymph nodes, extranodal tumour extension, and the occurrence of distant metastases.
  • [MeSH-major] Adenocarcinoma / metabolism. Carrier Proteins / metabolism. Colonic Neoplasms / metabolism. Microfilament Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / immunology. Carcinoma, Squamous Cell / metabolism. Female. Humans. Immunoenzyme Techniques. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 17375048.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Microfilament Proteins; 146808-54-0 / fascin
  • [Other-IDs] NLM/ PMC2360113
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44. Möhring C, Bach P, Kosciesza S, Goepel M: [A primary adenocarcinoma of the seminal vesicles. Case report of a rare malignancy]. Urologe A; 2008 May;47(5):616-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A primary adenocarcinoma of the seminal vesicles. Case report of a rare malignancy].
  • They must be strictly differentiated from surrounding malignancies that may infiltrate the seminal vesicles from outside (e.g. prostate, rectum, and bladder carcinoma).
  • Early diagnosis may be difficult due to lack of specific symptoms.
  • Primary diagnostic steps include digital rectal examination, transrectal ultrasound, and transrectal biopsy of the tumour.
  • Adenocarcinoma of seminal vesicles shows no expression of prostate-specific antigen or prostate-specific acid phosphatase, but there may be expression of carcinoembryonic antigen and cancer antigen 125.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Genital Neoplasms, Male / diagnosis. Seminal Vesicles
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Endosonography. Follow-Up Studies. Hematuria / etiology. Hemospermia / diagnosis. Humans. Lymph Node Excision. Magnetic Resonance Imaging. Male. Middle Aged. Prostatectomy

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  • (PMID = 18231770.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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45. Lam AK, Ong K, Ho YH: Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity. Hum Pathol; 2008 Apr;39(4):599-604
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity.
  • The aim of the present study was to investigate the clinicopathological roles of aurora kinase protein expression in a large cohort of patients with colorectal adenocarcinoma with tight methodology and close follow-up.
  • Mucinous adenocarcinomas were less often positive for the protein (16% versus 56%, P = .0001).
  • Aurora kinase protein expression was more commonly seen in carcinomas in the rectum, sigmoid, and descending colon than in the proximal colon (55% versus 36%, P = .01).
  • [MeSH-major] Adenocarcinoma / enzymology. Adenocarcinoma / pathology. Colorectal Neoplasms / enzymology. Colorectal Neoplasms / pathology. Protein-Serine-Threonine Kinases / metabolism

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  • (PMID = 18284933.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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46. Pande R, Sunga A, Levea C, Wilding GE, Bshara W, Reid M, Fakih MG: Significance of signet-ring cells in patients with colorectal cancer. Dis Colon Rectum; 2008 Jan;51(1):50-5
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  • The outcome of patients with a component of signet-ring cells was compared to all patients with mucinous adenocarcinoma (defined as adenocarcinomas with > or = 50 percent mucin) to all patients with adenocarcinomas with a component of mucin (defined as adenocarcinomas with < 50 percent mucin) and to 100 randomly selected patients with adenocarcinomas lacking mucin or signet-ring cells.
  • RESULTS: Five percent of patients had a component of signet-ring cells, 3 percent had mucinous adenocarcinoma, 9 percent had a component of mucinous adenocarcinoma, and 83 percent had adenocarcinoma lacking mucinous or signet components.
  • Patients with a component of signet-ring cells and mucinous adenocarcinomas metastasized predominantly to the peritoneum/ovaries (75 and 56 percent of metastatic cases, respectively) and rarely to liver/lungs.
  • The pattern of metastases of patients with adenocarcinoma without mucinous or signet components predominantly involved the liver/lungs and rarely the peritoneum/ovaries (12.5 percent).
  • The pattern of metastases for patients with a component of mucinous adenocarcinoma was intermediate between mucinous adenocarcinoma and adenocarcinoma without mucin or signet-ring component.
  • CONCLUSIONS: Patients with a component of signet-ring cells cancers, similar to mucinous adenocarcinoma, have a predisposition to metastasize to the peritoneum/ovaries.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Signet Ring Cell / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Incidence. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 18030531.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. McGory ML, Maggard MA, Kang H, O'Connell JB, Ko CY: Malignancies of the appendix: beyond case series reports. Dis Colon Rectum; 2005 Dec;48(12):2264-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: All patients diagnosed with mucinous adenocarcinoma (n = 951), adenocarcinoma (n = 646), carcinoid (n = 435), goblet (n = 369), and signet-ring cell (n = 113) in the Surveillance, Epidemiology, and End Results database (1973-2001) were analyzed.
  • The most common appendiceal tumors were mucinous.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Carcinoma, Signet Ring Cell / pathology

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  • (PMID = 16258711.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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48. Manxhuka-Kerliu S, Telaku S, Ahmetaj H, Baruti A, Loxha S, Kerliu A: Colorectal cancer: prognostic values. Bosn J Basic Med Sci; 2009 Feb;9(1):19-24
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  • Adenocarcinoma was the most frequent histological type found in 85,90% of cases, in 60,94% of males and 39,06% of females; squamous cell carcinoma in 7,38%, in 63,63% of males and 36,36% of females; mucinous carcinoma in 4,68%, in 57,15% of males and 42,85% of females; while adenosquamous carcinoma, undifferentiated carcinoma and carcinoma in situ in 0,71% of cases each.

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  • (PMID = 19284390.001).
  • [ISSN] 1512-8601
  • [Journal-full-title] Bosnian journal of basic medical sciences
  • [ISO-abbreviation] Bosn J Basic Med Sci
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Bosnia and Herzegovina
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49. Benedix F, Reimer A, Gastinger I, Mroczkowski P, Lippert H, Kube R, Study Group Colon/Rectum Carcinoma Primary Tumor: Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study. Eur J Surg Oncol; 2010 Aug;36(8):763-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: During a five-year period, 196 consecutive patients with malignant appendiceal tumors were distributed into four groups: appendiceal carcinoids, adenocarcinoma, mucinous adenocarcinoma and adenosquamous carcinoma.
  • RESULTS: Adenocarcinoma had the highest incidence (50.5%).
  • Metastatic spread at presentation was highest for adenosquamous and mucinous adenocarcinoma and each had a distinct pattern.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Appendicitis / diagnosis. Carcinoid Tumor / epidemiology. Carcinoid Tumor / surgery. Carcinoma, Adenosquamous / epidemiology. Carcinoma, Adenosquamous / surgery. Diagnosis, Differential. Female. Germany. Humans. Male. Middle Aged. Neoplasm Staging. Unnecessary Procedures / statistics & numerical data

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20561765.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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50. Kudo K, Funayama Y, Fukushima K, Shibata C, Takahashi K, Ogawa H, Ueno T, Haneda S, Watanabe K, Koyama A, Hayashi K, Hiwatashi N, Kinouchi Y, Shimosegawa T, Sasaki I: [Carcinoma arising from ileorectal fistula in a patient with Crohn's disease]. Nihon Shokakibyo Gakkai Zasshi; 2007 Oct;104(10):1492-7
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  • A 72-year-old man was given a diagnosis of Crohn's disease in 1976 at age 44, and partial resection of is ileum was performed.
  • Endoscopic examination showed a fistula orifice in the rectum and biopsy of the fistula revealed mucinous adenocarcinoma.
  • We performed abdominoperineal resection of the rectum with partial resection of the sacrum.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Crohn Disease / complications. Ileal Diseases / complications. Intestinal Fistula / complications. Rectal Fistula / complications. Rectal Neoplasms / etiology
  • [MeSH-minor] Aged. Humans. Male. Rectum / surgery. Sacrum / surgery

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  • (PMID = 17917397.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 12
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51. Farquharson AL, Pranesh N, Witham G, Swindell R, Taylor MB, Renehan AG, Rout S, Wilson MS, O'Dwyer ST, Saunders MP: A phase II study evaluating the use of concurrent mitomycin C and capecitabine in patients with advanced unresectable pseudomyxoma peritonei. Br J Cancer; 2008 Aug 19;99(4):591-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pseudomyxoma peritonei (PMP) is a rare neoplastic process characterised by progressive intra-abdominal dissemination of mucinous tumour, and generally considered resistant to systemic chemotherapy.
  • Of 39 assessable patients, 15 (38%, 95% confidence intervals (CIs): 25, 54%) benefited from chemotherapy in the form of either reductions in mucinous deposition or stabilisation of progressive pretreatment disease determined on CT scan.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Peritoneal Neoplasms / drug therapy. Pseudomyxoma Peritonei / drug therapy

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  • (PMID = 18682713.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0W860991D6 / Deoxycytidine; 50SG953SK6 / Mitomycin; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2527821
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52. Khan MN, Moran BJ: Four percent of patients undergoing colorectal cancer surgery may have synchronous appendiceal neoplasia. Dis Colon Rectum; 2007 Nov;50(11):1856-9
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  • The appendix has a similar mucosal pattern to the colon and it has been hypothesized that appendicular adenocarcinoma may account for 1 percent of all colorectal malignancies.
  • A special interest of the senior author in appendiceal and rectal cancer has prompted routine removal of the appendix in all cases undergoing surgery for colorectal cancer.
  • RESULTS: In total, 169 patients under the care of a single surgeon had colorectal cancer resection between April 2002 and April 2005: 63 patients had right hemicolectomy, 29 had left hemicolectomy, and 77 had rectal cancer resection.
  • Seven of 169 appendices had abnormalities: 3 mucinous cystadenomas, 2 cystadenocarcinomas, 1 carcinoid tumor, and 1 villous adenoma.
  • CONCLUSIONS: Patients having colorectal cancer resection for adenocarcinoma should have appendicectomy performed.
  • [MeSH-major] Adenocarcinoma / epidemiology. Appendiceal Neoplasms / epidemiology. Colorectal Neoplasms / epidemiology. Neoplasms, Multiple Primary / epidemiology

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  • (PMID = 17763906.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Melichar B, Bures J, Dedic K: Anorectal carcinoma after infliximab therapy in Crohn's disease: report of a case. Dis Colon Rectum; 2006 Aug;49(8):1228-33
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  • We report a case of mucinous anorectal adenocarcinoma observed in a 39-year-old patient with long-standing Crohn's disease after therapy with two courses of infliximab.
  • [MeSH-major] Adenocarcinoma / chemically induced. Antibodies, Monoclonal / therapeutic use. Crohn Disease / drug therapy. Rectal Neoplasms / chemically induced
  • [MeSH-minor] Adult. Humans. Infliximab. Male. Neoplasm Recurrence, Local

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  • (PMID = 16845561.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; B72HH48FLU / Infliximab
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54. Wang W, Zhou ZW, Wan DS, Lu ZH, Chen G, Pan ZZ, Li LR, Wu XJ, Ding PR: [Clinical analyses of 70 cases of multiple primary colorectal carcinoma]. Ai Zheng; 2008 May;27(5):505-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This study was to investigate the clinical characteristics, diagnosis, therapeutic principle and prognosis of MPCC.
  • [MeSH-major] Carcinoma, Ductal / surgery. Colectomy / methods. Colonic Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / surgery. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Rectum / surgery. Retrospective Studies. Survival Rate

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  • (PMID = 18479600.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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55. Chlumská A, Boudová L, Zámecník M: Sessile serrated adenomas of the large bowel. Clinicopathologic and immunohistochemical study including comparison with common hyperplastic polyps and adenomas. Cesk Patol; 2006 Jul;42(3):133-8
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  • The sites of SSAs were as follows: 8 in rectum, 4 in rectosigmoid colon, 1 in transverse colon, 1 next to mucinous carcinoma of ascending colon, 1 in anastomosis after resection of the transverse colon adenocarcinoma.
  • High-grade dysplasia was found only in SSA adjacent to mucinous adenocarcinoma.
  • Both MUC2 and MUC5A were also positive in mucinous carcinoma.
  • SSAs have malignant potential comparable with conventional adenomas and for this reason they must be distinguished from HPs.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Intestinal Polyps / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16955561.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucins
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56. Kuester D, Dalicho S, Mönkemüller K, Benedix F, Lippert H, Guenther T, Roessner A, Meyer F: Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis. Pathol Res Pract; 2008;204(12):905-10
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  • [Title] Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis.
  • Regardless of the diagnosis and medical advice, the patient initially refused therapy, and proctocolectomy was delayed for 12 months.
  • In the resection specimen, four clinically unsuspected, partly mucinous adenocarcinomas accompanied by several foci of low- and high-grade dysplasia were found in the left colon and rectum.
  • Furthermore, a mucinous cystadenoma was found in the appendix in the setting of ulcerative colitis.
  • [MeSH-major] Adenocarcinoma / pathology. Colitis, Ulcerative / complications. Colitis, Ulcerative / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adult. Appendiceal Neoplasms / pathology. Cystadenoma, Mucinous / pathology. Humans. Male. Neoplasm Staging. Neoplasms, Multiple Primary / pathology

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  • [CommentIn] Zentralbl Chir. 2015 Dec;140(6):624-6 [25076166.001]
  • (PMID = 18842350.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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57. Sideris L, Mitchell A, Drolet P, Leblanc G, Leclerc YE, Dubé P: Surgical cytoreduction and intraperitoneal chemotherapy for peritoneal carcinomatosis arising from the appendix. Can J Surg; 2009 Apr;52(2):135-41
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  • We used Ronnett's classification for tumour grading (disseminated peritoneal adenomucinosis = grade 0, peritoneal mucinous carcinomatosis with intermediate features = grade 1 and peritoneal mucinous carcinomatosis = grade 2).
  • [MeSH-major] Adenocarcinoma, Mucinous / therapy. Antineoplastic Agents / administration & dosage. Appendiceal Neoplasms / pathology. Hyperthermia, Induced. Peritoneal Neoplasms / therapy

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  • (PMID = 19399209.001).
  • [ISSN] 1488-2310
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 50SG953SK6 / Mitomycin; 7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
  • [Other-IDs] NLM/ PMC2663512
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58. Pahlavan PS, Kanthan R: Goblet cell carcinoid of the appendix. World J Surg Oncol; 2005 Jun 20;3:36

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Goblet cell carcinoid (GCC) of the appendix is a rare neoplasm that share histological features of both adenocarcinoma and carcinoid tumor.
  • While its malignant potential remains unclear, GCC's are more aggressive than conventional carcinoid.
  • The clinical presentations of this neoplasm are also varied.
  • The focus is on its diagnosis, histopathological aspects, clinical manifestations, and management.
  • METHODS: Published studies in the English language between 1966 to 2004 were identified through Medline keyword search utilizing terms "goblet cell carcinoid," "adenocarcinoid", "mucinous carcinoid" and "crypt cell carcinoma" of the appendix.
  • Accurate diagnosis of this neoplasm requires astute observations within an acutely inflamed appendix as this neoplasm has a prominent pattern of submucosal growth and usually lacks the formation of a well-defined tumor mass.
  • Concomitant distant metastasis at diagnosis was present in 11.16% of patients with the ovaries being the most common site in 3.60% followed by disseminated abdominal carcinomatosis in 1.03%.
  • Local lymph node involvement was seen in 8.76% of patients at the time of diagnosis.
  • GCC's of the appendix remains a neoplasm of unpredictable biological behavior and thus warrants lifelong surveillance for recurrence of the disease upon diagnosis and successful surgical extirpation.
  • CONCLUSION: GCC of the appendix is a rare neoplasm.
  • Due to its wide range of presentation, this tumor should be considered as a possible diagnosis in many varied situations leading to abdominal surgery.

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  • (PMID = 15967038.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
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59. Ericsson AC, Myles M, Davis W, Ma L, Lewis M, Maggio-Price L, Franklin C: Noninvasive detection of inflammation-associated colon cancer in a mouse model. Neoplasia; 2010 Dec;12(12):1054-65
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  • Most infected mice develop mucinous adenocarcinoma (MUC) by 6 weeks post inoculation (PI); however, approximately one third do not progress to MUC.

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  • (PMID = 21170269.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / K26 RR018811; United States / NCRR NIH HHS / RR / T32 RR007004; United States / NCRR NIH HHS / RR / 5T32 RR007004-32
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Chemokine CCL3; 0 / Interleukin-1beta; 0 / Smad3 Protein; 63231-63-0 / RNA
  • [Other-IDs] NLM/ PMC3003140
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60. Farhat MH, Barada KA, Tawil AN, Itani DM, Hatoum HA, Shamseddine AI: Effect of mucin production on survival in colorectal cancer: a case-control study. World J Gastroenterol; 2008 Dec 7;14(45):6981-5
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • AIM: To investigate the impact of mucin production on prognosis in colorectal cancer, in terms of overall survival (OS) and time to disease progression (TTP) in patients with mucinous compared to those with non-mucinous colorectal cancer (NMCRC), matched for age, gender, and tumor stage.
  • METHODS: Thirty five patients with mucinous colorectal cancer (MCRC) were matched for age, gender, and tumor stage with 35 controls having NMCRC.
  • Twenty-eight percent of patients with MCRC had poorly differentiated adenocarcinoma versus 8.6% in NMCRC patients (P=0.028).
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / mortality. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / mortality. Mucins / metabolism

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  • [Cites] J Surg Oncol. 1992 Sep;51(1):60-4 [1325577.001]
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  • (PMID = 19058335.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
  • [Other-IDs] NLM/ PMC2773863
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61. Paianidi IuG, Sel'chuk VIu, Zhordania KI, Anurova OA, Chemeris GIu, Zakharova TI, Savelov NA, Moroz EA: [Female genital tract polyneoplasia: primary multiple neoplasms or metastases?]. Arkh Patol; 2006 Jul-Aug;68(4):16-20
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  • The analysis of 49 cases of synchronous and metachronous malignant mucinous tumors of the colon (rectum) and ovaries in the patients treated in 1990 to 2004 again has confirmed the data that metastatic ovarian cancer occurs from a primary focus in the colorectal region.
  • Immunohistochemical studies (using cytokeratin 7 and cytokeratin 20) may be used in the differential diagnosis of ovarian mucinous ovarian carcinoma from metastatic colonic mucinous tumors.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / secondary. Colonic Neoplasms / pathology. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary

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  • (PMID = 16986489.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 68238-35-7 / Keratins
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62. Lu B, Fu CG, Liu LJ, Meng RG, Yu ED, Jin GX, Xing JJ, Yu DH: [Bowel control of elderly low rectal cancer patients after anus-retained operation]. Ai Zheng; 2005 Oct;24(10):1257-60
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  • [Title] [Bowel control of elderly low rectal cancer patients after anus-retained operation].
  • BACKGROUND & OBJECTIVE: Though anus-retained operation has became the first choice in radical cure operation for rectal cancer, most surgeons whom fear of dissatisfied bowel control after operation recommend permanent bowel stoma in abdomen for elderly low rectal cancer patients rather than anus-retained operation.
  • This study was to evaluate the bowel control of elderly low rectal cancer patients after anus-retained operation.
  • METHODS: A total of 80 elderly low rectal cancer patients were divided into > or =75-year old group (39 patients) and 60-74-year old group (41 patients).
  • CONCLUSIONS: Most elderly low rectal cancer patients could maintain bowel control after anus-retained operation.
  • Age alone should not be a contraindication to a restorative resection for low rectal cancer.
  • [MeSH-major] Anal Canal / physiopathology. Proctocolectomy, Restorative / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / physiopathology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / physiopathology. Adenocarcinoma, Mucinous / surgery. Age Factors. Aged. Aged, 80 and over. Anastomosis, Surgical. Defecation / physiology. Digestive System Surgical Procedures / methods. Fecal Incontinence / etiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Rectum / surgery

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  • (PMID = 16219144.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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63. Yamaguchi T, Iijima T, Mori T, Takahashi K, Matsumoto H, Miyamoto H, Hishima T, Miyaki M: Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer. Dis Colon Rectum; 2006 Mar;49(3):399-406
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • [MeSH-major] Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Frameshift Mutation. Neoplasm Proteins / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma, Mucinous / genetics. Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. Female. Humans. Male. Middle Aged


64. Salas-Valverde S, Lizano A, Gamboa Y, Vega S, Barrantes M, Santamaría S, Zamora JB: Colon carcinoma in children and adolescents: prognostic factors and outcome-a review of 11 cases. Pediatr Surg Int; 2009 Dec;25(12):1073-6
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  • BACKGROUND: Carcinoma of the colon and rectum is rare in the pediatric age group, and usually presents with an advanced stage disease bearing a poor prognosis.
  • Abdominal pain, acute intestinal obstruction, rectal bleeding and weight loss were the commonest symptoms.
  • Surgical procedures were done in 11 patients (incomplete resection with segmental resection in 4 patients, complete resection in the other 4, and biopsy alone in 3 patients).The predominant histological type was mucinous carcinoma.
  • CONCLUSIONS: Colorectal carcinoma in children is very uncommon and could be easily misdiagnosed, resulting in advanced stage disease at diagnosis.
  • Because radical surgery which is the mainstay of treatment is possible only in patients with early stage disease, a high level of awareness and early diagnosis are critical.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Antineoplastic Agents / therapeutic use. Colectomy / methods. Colonic Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Biopsy. Chemotherapy, Adjuvant. Child. Colonoscopy. Costa Rica / epidemiology. Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Male. Prognosis. Retrospective Studies. Survival Rate / trends

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  • (PMID = 19816697.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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65. Stojanović I, Karamehmedović Z, Elgazwi K, Baća I: Laparoscopic treatment of cystadenocarcinoma of the appendix penetrating in the sigmoid colon. JSLS; 2009 Jul-Sep;13(3):445-9
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  • Adenocarcinoma of the vermiform appendix is a rare neoplasm of the gastrointestinal tract that most commonly presents as right lower abdominal pain, mimicking acute appendicitis.
  • An accurate and complete preoperative diagnosis has been rare in the past; however, modern imaging techniques allow recognition of most complications and associated conditions.
  • The diagnosis is confirmed postoperatively.
  • Aggressive surgical management is the treatment of choice in appendicular adenocarcinoma.
  • We report the case of appendicular mucinous cystadenocarcinoma in a 55-year-old lady with penetration of the sigmoid colon treated with laparoscopic-assisted sigmoid and en block right hemicolectomy.

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  • (PMID = 19793493.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ PMC3015953
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66. Stelow EB, Moskaluk CA, Mills SE: The mismatch repair protein status of colorectal small cell neuroendocrine carcinomas. Am J Surg Pathol; 2006 Nov;30(11):1401-4
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  • It can be associated with conventional-type adenocarcinoma, and an overlying adenoma can often be identified.
  • Although some phenotypes (eg, mucinous adenocarcinoma) have been shown to be associated with deficient mismatch repair (MMR) and thus microsatellite instability (MSI), the MMR protein status of colorectal SCNCs has not been investigated.
  • Fifteen SCNCs were identified on the basis of previous descriptions and the World Health Organization histologic criteria for the diagnosis of pulmonary small cell carcinoma and immunohistochemical evidence of epithelial and neuroendocrine differentiation.
  • Tumors were located in the right colon (6), sigmoid colon (4), and rectum (3) (the locations of 2 cases were not recorded) and ranged in size from 0.4 to 15 cm in greatest dimension (mean = 6.6 cm).

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  • (PMID = 17063080.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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67. Wittekind C, Tischoff I: [Histopathological faults and their importance for staging and therapy]. Zentralbl Chir; 2006 Apr;131(2):157-61
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  • The most critical opportunities for producing mistakes are the histopathological examination, diagnosis and classifications.
  • Generally, the use of forms, check lists and standardized diagnosis sheets may help to reduce the mistake rates.
  • [MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Diagnostic Errors
  • [MeSH-minor] Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / therapy. Carcinoma, Signet Ring Cell / mortality. Carcinoma, Signet Ring Cell / pathology. Carcinoma, Signet Ring Cell / therapy. Chemotherapy, Adjuvant. Colon / pathology. Combined Modality Therapy. Humans. Medical Errors. Neoadjuvant Therapy. Neoplasm Staging. Neoplasm, Residual / mortality. Neoplasm, Residual / pathology. Neoplasm, Residual / therapy. Prognosis. Radiotherapy, Adjuvant. Rectum / pathology. Survival Rate. Treatment Outcome

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  • (PMID = 16612783.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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68. Kazakov DV, Mikyskova I, Mukensnabl P, Brouckova M, Treska V, Hes O, Michal M: Reactive syringofibroadenomatous hyperplasia in peristomal skin with formation of hybrid epidermal-colonic mucosa glandular structures, intraepidermal areas of sebaceous differentiation, induction of hair follicles, and features of human papillomavirus infection: a diagnostic pitfall. Am J Dermatopathol; 2005 Apr;27(2):135-41
MedlinePlus Health Information. consumer health - Skin Conditions.

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  • The patient was a 62-year-old woman who had undergone abdominoperineal resection of the rectum for rectal adenocarcinoma with subsequent colostomy 2 years earlier.
  • Following a clinical suspicion of adenocarcinoma, recurrent at the colostomy site, a 5 x 4 x 3-cm excision of the peristomal skin and the affected portion of the stoma was performed and submitted for histologic examination.
  • Several unusual histopathological features were detected in the syringofibroadenomatous part of the lesion such as the formation of plentiful hybrid epidermal-colonic mucosa glandular structures, intraepidermal areas of sebaceous differentiation, koilocytic changes, induction of rudimentary hair follicles, and intradermal mucinous lakes.
  • Being located at a distance from the stoma, these accentuated colonic mucosa epithelial glands reaching the epidermis may be a diagnostic pitfall prompting the consideration of adenocarcinoma involving the stoma.
  • [MeSH-minor] Adenocarcinoma / pathology. Diagnosis, Differential. Female. Humans. Hyperplasia / metabolism. Hyperplasia / pathology. Hyperplasia / virology. Immunohistochemistry. Middle Aged. Papillomaviridae. Polymerase Chain Reaction. Rectal Neoplasms / pathology

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  • (PMID = 15798439.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Yang BL, Gu YF, Shao WJ, Chen HJ, Sun GD, Jin HY, Zhu X: Retrorectal tumors in adults: magnetic resonance imaging findings. World J Gastroenterol; 2010 Dec 14;16(46):5822-9
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  • Presence of intracystic intermediate signal intensity was observed in one case of tailgut cyst with a component of adenocarcinoma.
  • Six solid tumors were malignant lesions and showed heterogeneous intensity on MRI.
  • Mucinous adenocarcinomas showed high signal intensity on T2-weighted and mesh-like enhancing areas on fat-suppressed T2-weighted images.
  • There was a fistula between the mass and anus with an internal opening in mucinous adenocarcinomas arising from anal fistula.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Rectal Neoplasms / pathology

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  • (PMID = 21155003.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3001973
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70. Devon KM, Brown CJ, Burnstein M, McLeod RS: Cancer of the anus complicating perianal Crohn's disease. Dis Colon Rectum; 2009 Feb;52(2):211-6
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  • METHODS: Charts of patients who had documented perianal Crohn's disease and a pathologic diagnosis of anal carcinoma were reviewed.
  • RESULTS: There were 14 patients (6 men; mean age, 49 years) who had evidence of perianal Crohn's disease (mean, 6.9 (range, 1-20) years) before their cancer diagnosis.
  • The diagnosis often was delayed despite increasing pain, multiple biopsies, and imaging studies.
  • There were 11 adenocarcinomas (8 mucinous or colloid subtypes) and 3 squamous-cell carcinomas.
  • [MeSH-minor] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Adult. Aged. Anal Canal / pathology. Anus Diseases / complications. Anus Diseases / pathology. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / diagnosis. Female. Humans. Male. Middle Aged

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  • (PMID = 19279414.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Buttarelli M, Houvenaeghel G, Lelièvre L, Jacquemier J, Guiramand J, Delpero JR: [Pelvic posterior exenteration with immediate colo-rectal anastomosis: is it justified and feasible in advanced stage ovarian carcinoma?]. Ann Chir; 2006 Oct;131(8):431-6
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  • [Title] [Pelvic posterior exenteration with immediate colo-rectal anastomosis: is it justified and feasible in advanced stage ovarian carcinoma?].
  • PURPOSE: The aim of this study is to show that the removal of the rectum is not an obstacle to implement an optimal surgery in advanced epithelial cancer of the ovary.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Endometrioid / surgery. Carcinosarcoma / surgery. Colon / surgery. Ovarian Neoplasms / surgery. Pelvic Exenteration. Rectum / surgery
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / surgery. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Aged, 80 and over. Anastomosis, Surgical. Colostomy. Cystadenocarcinoma, Serous / pathology. Cystadenocarcinoma, Serous / surgery. Cystectomy. Feasibility Studies. Female. Humans. Hysterectomy. Ileostomy. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Ovary / pathology. Preoperative Care. Quality of Life. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 16707093.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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72. Gupta S, Parsa V, Adsay V, Heilbrun LK, Smith D, Shields AF, Weaver D, Philip PA, El-Rayes BF: Clinicopathological analysis of primary epithelial appendiceal neoplasms. Med Oncol; 2010 Dec;27(4):1073-8
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  • Appendiceal carcinomas are classified into three distinct histopathological disease entities: disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), or peritoneal mucinous carcinomatosis with intermediate or discorant features (PMCA I/D).
  • Chart review for age, gender, signs and symptoms at diagnosis, and treatment was performed.
  • The prognosis and management of these tumors should be based on the extent of disease and pathologic diagnosis.

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  • [Cites] Ann Surg Oncol. 2005 Jan;12(1):72-80 [15827781.001]
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  • (PMID = 19851895.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA022453; United States / NCI NIH HHS / CA / CA-22453
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS513798; NLM/ PMC3883058
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73. Rambau PF, Odida M, Wabinga H: p53 expression in colorectal carcinoma in relation to histopathological features in Ugandan patients. Afr Health Sci; 2008 Dec;8(4):234-8
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  • RESULTS: Out of 109 patient's tissue blocks that were studied, 61 cases (56%) expressed p53 protein in the nucleus of malignant cells.
  • p53 protein was expressed more in left sided colonic tumors with a significant difference (p<0.05), it was also expressed more in well differentiated tumors and non mucinous adenocarcinomas but with no significant difference (p>0.05).
  • [MeSH-major] Adenocarcinoma, Mucinous / genetics. Carcinoma, Signet Ring Cell / genetics. Colorectal Neoplasms / genetics. Gene Expression Profiling. Genes, p53 / genetics. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adolescent. Adult. African Continental Ancestry Group. Age Distribution. Aged. Aged, 80 and over. Biomarkers, Tumor / genetics. Biopsy. Child. DNA, Neoplasm / genetics. Disease Progression. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Uganda

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  • (PMID = 20589130.001).
  • [ISSN] 1729-0503
  • [Journal-full-title] African health sciences
  • [ISO-abbreviation] Afr Health Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Uganda
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC2887007
  • [Keywords] NOTNLM ; Immunohistochemistry / colorectal carcinoma / p53
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74. Fujita S, Yamamoto S, Akasu T, Moriya Y, Taniguchi H, Shimoda T: Quantification of CD10 mRNA in colorectal cancer and relationship between mRNA expression and liver metastasis. Anticancer Res; 2007 Sep-Oct;27(5A):3307-11
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  • TIN was higher in colon, pN1/pN2, stage III and IV, and well- or moderately-differentiated adenocarcinoma than in rectum, pNO, stage I and II, and poorly-differentiated or mucinous adenocarcinoma, respectively.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / immunology. Adenocarcinoma / pathology. Adenocarcinoma / secondary. Female. Humans. Male. Middle Aged. Neoplasm Staging. Polymerase Chain Reaction

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  • (PMID = 17970075.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 3.4.24.11 / Neprilysin
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75. Ikeuchi H, Nakano H, Uchino M, Nakamura M, Matsuoka H, Fukuda Y, Matsumoto T, Takesue Y, Tomita N: Intestinal cancer in Crohn's disease. Hepatogastroenterology; 2008 Nov-Dec;55(88):2121-4
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  • AIMS: We investigated Crohn's Disease (CD) patients with carcinomas in the intestinal tract to emphasize the difficulty in establishing a diagnosis, as well as show the importance of establishing formal guidelines for screening and surveillance of cancers associated with perianal CD.
  • RESULTS: In 9 of the patients, carcinomas developed in relation to CD, 7 of whom had cancer of the lower rectum and anus with severe anorectal CD lesions.
  • Two patients with a carcinoma of the fistula in the ileo-rectum or ileo-sigmoid colon were treated by a partial resection of the small and large bowel with the fistula.
  • Mucinous cell type carcinomas were present in 6 patients, while signet ring cell type was found in 2 patients and poorly differentiated adenocarcinoma in 1.

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  • (PMID = 19260489.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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76. Schowinsky JT, Epstein JI: Distorted rectal tissue on prostate needle biopsy: a mimicker of prostate cancer. Am J Surg Pathol; 2006 Jul;30(7):866-70
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  • [Title] Distorted rectal tissue on prostate needle biopsy: a mimicker of prostate cancer.
  • Rectal tissue is often seen in needle biopsies of the prostate gland.
  • On rare occasion distorted rectal glands can mimic prostatic adenocarcinoma, an issue not previously addressed in the peer-reviewed literature.
  • We evaluated 16 prostate needle biopsies received in consultation where the submitting pathologist questioned whether a focus of rectal tissue was prostate cancer.
  • (1) blue-tinged intraluminal mucinous secretions in 10 cases (63%), (2) prominent nucleoli in 6 cases (37%), (3) mitotic activity in 6 cases (37%), (4) extracellular mucin in 5 cases (31%), and (5) adenomatous changes of the rectal tissue in 1 case (6%).
  • Diagnostic clues to recognizing that these foci were distorted rectal fragments were the presence of (1) lamina propria in 12 cases (75%), (2) rectal tissue located on a detached fragment of tissue in 10 biopsies (63%), (3) associated inflammation in 10 cases (63%), (4) goblet cells in 7 cases (44%), and (5) muscularis propria in 6 cases (37%).
  • Rectal glands are associated with many of the classical features of prostate cancer, and immunohistochemistry may be misleading.
  • Recognition of these features mimicking prostate cancer and awareness of other findings that are diagnostic of rectal tissue on biopsy can prevent a misdiagnosis of atypical prostate glands or prostate cancer.
  • [MeSH-major] Adenocarcinoma / pathology. Biopsy, Needle. Diagnostic Errors. Prostatic Neoplasms / pathology. Rectum / anatomy & histology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Intestinal Mucosa / anatomy & histology. Intestinal Mucosa / metabolism. Keratins / metabolism. Male. Mucins / metabolism. Prostate-Specific Antigen / metabolism. Racemases and Epimerases / metabolism

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  • (PMID = 16819329.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins; 68238-35-7 / Keratins; EC 3.4.21.77 / Prostate-Specific Antigen; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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77. Pahlavan PS, Kanthan R: The epidemiology and clinical findings of colorectal cancer in Iran. J Gastrointestin Liver Dis; 2006 Mar;15(1):15-9
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  • The tumors were categorized according to their distribution as appendix (n=4), cecum ( n=7), right colon (n=1), hepatic flexure (n=2), transverse colon (n=19), splenic flexure (n=3), left colon (n=6), sigmoid ( n=16), rectum (n=117), rectosigmoid and rectal lesions (n=16), and colorectal lesions without known locations (n=9).
  • Non-mucinous adenocarcinoma (AC) was the most common histological type (n=181, 90%), followed by mucinous AC (n=15), squamous cell carcinoma (n=1), carcinoid (n=1), melanoma (n=1) and signet ring carcinoma (n=1).
  • The most common presenting symptom was rectal bleeding (n=68, 34.5%).
  • Younger patients had a greater preponderance of mucinous AC (p=0.008) and generally underwent more extensive chemotherapy as seen with more usage of 5-Fluorouracil (p=0.05).

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  • (PMID = 16680227.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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78. Toyoda A, Kawana H, Azuhata K, Yu J, Omata A, Kishi H, Higashi M, Harigaya K: Aberrant expression of human ortholog of mammalian enabled (hMena) in human colorectal carcinomas: implications for its role in tumor progression. Int J Oncol; 2009 Jan;34(1):53-60
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  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma, Mucinous / metabolism. Adenoma / metabolism. Colorectal Neoplasms / metabolism. Microfilament Proteins / metabolism
  • [MeSH-minor] Aged. Blotting, Western. Cell Movement. Colon / metabolism. Colon / pathology. Disease Progression. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. Rectum / metabolism. Rectum / pathology. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 19082477.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Enah protein, human; 0 / Microfilament Proteins; 0 / RNA, Messenger
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79. Li CS, Wan DS, Pan ZZ, Zhou ZW, Chen G, Wu XJ, Li LR, Lu ZH, Ding PR, Li Y: [Multivariate prognostic analysis of patients with low and middle rectal cancer after curative resection]. Ai Zheng; 2006 May;25(5):587-90
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  • [Title] [Multivariate prognostic analysis of patients with low and middle rectal cancer after curative resection].
  • BACKGROUND & OBJECTIVE: The incidence of low and middle rectal cancer is high in China.
  • This study was to evaluate the correlation of clinicopathologic features to the prognosis in low and middle rectal cancer.
  • METHODS: The clinicopathologic data of 599 patients with low and middle rectal cancer, treated from 1990 to 1999 in Cancer Center of Sun Yat-sen University, were analyzed retrospectively.
  • CONCLUSIONS: Local recurrence, perioperative blood transfusion, lymph node metastasis, and T stage are important prognostic factors of low and middle rectal cancer.
  • LAR has become the preferred option in curative surgery for low and middle rectal cancer.
  • [MeSH-major] Adenocarcinoma / surgery. Digestive System Surgical Procedures / methods. Rectal Neoplasms / surgery. Rectum / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Adult. Blood Transfusion. Carcinoma, Signet Ring Cell / pathology. Carcinoma, Signet Ring Cell / surgery. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Proportional Hazards Models. Retrospective Studies. Survival Rate

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  • (PMID = 16687079.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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80. Tuppurainen K, Mäkinen JM, Junttila O, Liakka A, Kyllönen AP, Tuominen H, Karttunen TJ, Mäkinen MJ: Morphology and microsatellite instability in sporadic serrated and non-serrated colorectal cancer. J Pathol; 2005 Nov;207(3):285-94
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  • Colorectal serrated adenocarcinoma originates from serrated adenoma, but definite histological criteria have not yet been established.
  • It presents with frequent DNA microsatellite instability (MSI), but the frequency of low-level (MSI-L) and high-level MSI (MSI-H) and the expression of mismatch-repair (MMR) enzymes in serrated adenocarcinoma are not known.
  • Serrated carcinomas frequently showed a serrated, mucinous or trabecular growth pattern; abundant eosinophilic cytoplasm; chromatin condensation; preserved polarity; and the absence of necrosis.
  • [MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Microsatellite Repeats / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma / genetics. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Base Pair Mismatch / genetics. Biomarkers, Tumor / genetics. Carrier Proteins / genetics. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Colon / pathology. DNA, Neoplasm / genetics. Eosinophils / pathology. Female. Humans. Immunohistochemistry / methods. Male. Middle Aged. Neoplasm Proteins / genetics. Nuclear Proteins / genetics. Observer Variation. Rectum / pathology

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  • [Copyright] Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 16177963.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins
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81. Sarikaya I, Bloomston M, Povoski SP, Zhang J, Hall NC, Knopp MV, Martin EW Jr: FDG-PET scan in patients with clinically and/or radiologically suspicious colorectal cancer recurrence but normal CEA. World J Surg Oncol; 2007;5:64
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  • In 3 patients with false negative PET, histopathology was consistent with mucinous adenocarcinoma.
  • [MeSH-major] Carcinoembryonic Antigen / analysis. Colorectal Neoplasms / pathology. Fluorodeoxyglucose F18. Neoplasm Recurrence, Local / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Metastasis / radionuclide imaging. Sensitivity and Specificity

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  • (PMID = 17555577.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC1896164
  • [General-notes] NLM/ Original DateCompleted: 20070731
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82. Abdulkareem FB, Abudu EK, Awolola NA, Elesha SO, Rotimi O, Akinde OR, Atoyebi AO, Adesanya AA, Daramola AO, Banjo AA, Anunobi CC: Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: a histopathological review. World J Gastroenterol; 2008 Nov 14;14(42):6531-5
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  • The majority was well to moderately differentiated adenocarcinoma 321 (76.4%), mucinous carcinoma 45 (10.7%) and signet ring carcinoma 5 (1.2%), and more common in patients under 40 years compared to well differentiated tumors.
  • CONCLUSION: CRC is the commonest malignant gastrointestinal (GIT) tumor most commonly located in the recto-sigmoid region.

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  • (PMID = 19030207.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA094143
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2773341
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83. da Silva RG, Sugarbaker PH: Analysis of prognostic factors in seventy patients having a complete cytoreduction plus perioperative intraperitoneal chemotherapy for carcinomatosis from colorectal cancer. J Am Coll Surg; 2006 Dec;203(6):878-86
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  • The difference in negative versus positive lymph nodes was also significant; differences in survival that were improved but not significant were present for age greater than 30 years, mucinous histology, location within the colon versus rectum, and absence of an adverse factor such as cancer perforation or obstruction present at the time of primary cancer resection.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Colorectal Neoplasms / pathology. Perioperative Care. Peritoneal Lavage. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / therapy. Peritoneum / surgery

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  • (PMID = 17116556.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
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84. Tokai H, Kawashita Y, Eguchi S, Kamohara Y, Takatsuki M, Okudaira S, Tajima Y, Hayashi T, Kanematsu T: A case of mucin producing liver metastases with intrabiliary extension. World J Gastroenterol; 2006 Aug 14;12(30):4918-21
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  • A 75-year-old man was admitted to our hospital with a diagnosis of liver metastases from colon cancer.
  • Histopathological examination of the resected specimens from both operations revealed a well-differentiated adenocarcinoma with mucinous carcinoma.
  • With a tentative diagnosis of a recurrence of metastatic cancer, partial hepatectomy of S8 was performed.
  • Histological examination of the resected specimens also revealed mucinous adenocarcinoma, which had invaded into the biliary ducts, replacing and extending along its epithelium.
  • Therefore, the tumor was diagnosed as a metastatic adenocarcinoma from colonic cancer.
  • Liver metastases of colorectal adenocarcinoma sometimes invade the Glisson's triad and grow along the biliary ducts.
  • [MeSH-major] Adenocarcinoma. Bile Duct Neoplasms / metabolism. Bile Duct Neoplasms / secondary. Colonic Neoplasms / pathology. Liver Neoplasms / metabolism. Liver Neoplasms / secondary. Mucins / metabolism
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Neoplasm Metastasis

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  • (PMID = 16937483.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Mucins
  • [Other-IDs] NLM/ PMC4087635
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85. Bae JM, Kim SW, Kim SW, Song SK: [Metachronous four primary malignancies in gastro-intestinal tract]. Korean J Gastroenterol; 2009 Jun;53(6):373-7

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  • Recently, we experienced a 70 year-old male who was diagnosed with metachronous four primary malignancies in rectum, ascending colon, stomach, and ampulla of Vater.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis. Gastrointestinal Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / surgery. Aged. Colonic Neoplasms / diagnosis. Colonic Neoplasms / surgery. Humans. Male. Rectal Neoplasms / diagnosis. Rectal Neoplasms / surgery. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery. Tomography, X-Ray Computed

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  • (PMID = 19556845.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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86. Allen SD, Padhani AR, Dzik-Jurasz AS, Glynne-Jones R: Rectal carcinoma: MRI with histologic correlation before and after chemoradiation therapy. AJR Am J Roentgenol; 2007 Feb;188(2):442-51
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  • [Title] Rectal carcinoma: MRI with histologic correlation before and after chemoradiation therapy.
  • OBJECTIVE: The purpose of this study was to use MRI to compare the morphologic features of rectal cancer before and 6 weeks after chemotherapy and radiation treatment to correlate the posttreatment MRI appearances with the histologic findings in resected tumors.
  • MATERIALS AND METHODS: High-resolution T2-weighted MRI was performed before and immediately after a standardized 5-week course of chemoradiation therapy in the care of 30 patients with locally advanced adenocarcinoma of the rectum.
  • MRI was not useful for gauging disease activity of persistent abnormalities in mucinous tumors that often represented inactive mucin lakes.
  • Errors were caused by the presence of considerable tumor, rectal wall fibrosis, and mucinous tumors.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Magnetic Resonance Imaging / methods. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / prevention & control. Rectal Neoplasms / diagnosis. Rectal Neoplasms / therapy

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  • (PMID = 17242254.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
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87. Luo DC, Cai Q, Sun MH, Ni YZ, Ni SC, Chen ZJ, Li XY, Tao CW, Zhang XM, Shi DR: Clinicopathological and molecular genetic analysis of HNPCC in China. World J Gastroenterol; 2005 Mar 21;11(11):1673-9

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  • Average age at diagnosis of the first CRC was 45.7 years; 40.9% and 28.7% of the CRCs were located proximal to the splenic flexure and in the rectum, respectively.
  • 34.4% and 25% of the CRCs were poor differentiation cancer and mucinous adenocarcinoma, respectively.
  • [MeSH-major] Asian Continental Ancestry Group / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / pathology. DNA-Binding Proteins / genetics. Neoplasm Proteins / genetics. Proto-Oncogene Proteins / genetics

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  • (PMID = 15786548.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / MLH1 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
  • [Other-IDs] NLM/ PMC4305952
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88. Mirza NN, McCloud JM, Cheetham MJ: Clostridium septicum sepsis and colorectal cancer - a reminder. World J Surg Oncol; 2009;7:73
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  • One patient was found to have a perforated caecal tumour intraoperatively whilst the other had a perforated rectal tumour.
  • The cumulative effect of sepsis and malignant perforation is associated with a high morbidity and mortality.
  • Awareness and early diagnosis of clostridium septicum may improve the prognosis of what is usually regarded as a fatal infection.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / microbiology. Clostridium Infections / complications. Clostridium septicum / isolation & purification. Colorectal Neoplasms / complications. Colorectal Neoplasms / microbiology
  • [MeSH-minor] Adenocarcinoma, Mucinous / complications. Adenocarcinoma, Mucinous / microbiology. Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / surgery. Aged. Aged, 80 and over. Anti-Bacterial Agents / therapeutic use. Cecum / microbiology. Cecum / pathology. Fatal Outcome. Female. Humans. Intestinal Perforation / microbiology. Rectum / microbiology. Rectum / pathology

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  • (PMID = 19807912.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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  • [Other-IDs] NLM/ PMC2761909
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89. Brosens RP, Oomen JL, Glas AS, van Bochove A, Cuesta MA, Engel AF: POSSUM predicts decreased overall survival in curative resection for colorectal cancer. Dis Colon Rectum; 2006 Jun;49(6):825-32
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • Risk factors for overall survival were advanced stage of disease, poor tumor differentiation, mucinous adenocarcinoma, older than age 70 years, and poor condition of the patient at time of operation.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Colorectal Neoplasms / mortality. Colorectal Neoplasms / surgery. Severity of Illness Index

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  • (PMID = 16550320.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Sulkowska M, Famulski W, Wincewicz A, Moniuszko T, Kedra B, Koda M, Zalewski B, Baltaziak M, Sulkowski S: Levels of VE-cadherin increase independently of VEGF in preoperative sera of patients with colorectal cancer. Tumori; 2006 Jan-Feb;92(1):67-71
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  • VE-cadherin was not correlated with VEGF in the entire group of CRC patients nor in the subgroups of node-positive and node-negative patients, different grades of histological differentiation (G2 or G3), extent of tumor growth (pT1+pT2 or pT3+pT4), histopathological type (adenocarcinoma or mucinous carcinoma), sex, age, and tumor site (colon or rectum).
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma, Mucinous / blood. Aged. Antigens, CD. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Preoperative Care

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  • (PMID = 16683386.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Vascular Endothelial Growth Factor A; 0 / cadherin 5
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91. Lohsiriwat V, Vongjirad A, Lohsiriwat D: Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance. World J Surg Oncol; 2009;7:51
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  • [Title] Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance.
  • BACKGROUND: The aims of this study were to evaluate the incidence of synchronous appendiceal neoplasm in patients with colorectal cancer, and to determine its clinical significance.
  • METHODS: Pathological reports and medical records were reviewed of patients with colorectal adenocarcinoma who underwent oncological resection of the tumor together with appendectomy at the Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand between September 2000 and April 2008.
  • Of the patients studied, 228 (78 percent) had right hemicolectomy, whereas the others (22 percent) had surgery for left-sided colon cancer or rectal cancer.
  • One patient (0.3 percent) had epithelial appendiceal neoplasm (mucinous cystadenoma) and 3 patients (1.0 percent) had metastatic colorectal cancer in the mesoappendix.
  • CONCLUSION: The incidence of synchronous primary appendiceal neoplasm and secondary (metastatic) appendiceal neoplasm in colorectal cancer patients was 0.3 and 1.0 percent, respectively.

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  • (PMID = 19490638.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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92. Sulkowski S, Kanczuga-Koda L, Koda M, Wincewicz A, Sulkowska M: Insulin-like growth factor-I receptor correlates with connexin 26 and Bcl-xL expression in human colorectal cancer. Ann N Y Acad Sci; 2006 Dec;1090:265-75
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  • Associations among the above proteins were assessed in the entire group of colorectal cancer patients and its subgroups, depending on lymph node involvement (N0 and N1), histological grade (G2 and G3), extent of tumor growth (pT1+pT2 and pT3+pT4), histopathologic type (adenocarcinoma and mucinous carcinoma), sex, age (<or=60 and>60), and tumor site (colon and rectum).

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  • (PMID = 17384270.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Connexins; 0 / bcl-X Protein; 127120-53-0 / connexin 26; EC 2.7.10.1 / Receptor, IGF Type 1
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93. Hoeffel C, Marcus C, Arrivé L, Bouché O, Tubiana J: [Postoperative imaging after colorectal surgery]. J Radiol; 2009 Jul-Aug;90(7-8 Pt 2):954-68
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  • In addition to classical surgical procedures (colectomy, abdominoperineal resection), new surgical procedures include coloproctectomy with creation of an ileoanal anastomosis and ileal pouch, pelvic reconstructions (omentoplasty, placement of myocutaneous flaps) and creation of different colic anastomoses after anterior rectal resection.
  • Even if computed tomography and fluoroscopic contrast examinations are still commonly used to assess postoperative changes and complications, especially infections, pelvic magnetic resonance imaging is useful to depict postoperative changes, detect complications such as fistulas and tumor recurrence in patients who have undergone surgery for primary or recurrent rectal disease.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Colon / surgery. Colonic Neoplasms / surgery. Magnetic Resonance Imaging / methods. Postoperative Complications / diagnosis. Postoperative Complications / radiography. Rectal Neoplasms / surgery. Rectum / surgery. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Colectomy / methods. Colonic Pouches. Contrast Media. Female. Fluoroscopy. Follow-Up Studies. Humans. Laparoscopy. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / radiography. Proctocolectomy, Restorative. Time Factors

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  • (PMID = 19752833.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 27
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94. Suzuki T, Suzuki T, Shinoda M, Takashi H, Yamaguchi H, Murayama M, Kamiya T, Morise K, Tashiro K, Kimura M, Yamagishi S, Ando T, Goto H: [An autopsy case of colon cancer associated ulcerative colitis complicated focal squamous cell carcinoma]. Nihon Shokakibyo Gakkai Zasshi; 2007 May;104(5):684-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • At autopsy, the histological examination showed many mucinous adenocarcinoma and signet ring cell carcinoma with dysplasia.
  • There were also some areas of squamous cell carcinoma with squamous metaplasia and dysplasia far from rectum.

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  • (PMID = 17485949.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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95. Zhao DB, Gao JD, Bi JJ, Shao YF, Zhao P: [Lymph node metastasis and prognosis in T1 and T2 rectal carcinoma]. Zhonghua Zhong Liu Za Zhi; 2006 Mar;28(3):235-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lymph node metastasis and prognosis in T1 and T2 rectal carcinoma].
  • OBJECTIVE: To investigate the characteristics of lymph node metastasis and prognosis of T1/T2 rectal carcinoma.
  • METHODS: The clinical data of 241 patients with T1 or T2 rectal carcinoma were retrospectively analyzed.
  • CONCLUSION: Even though lymph node metastasis can be observed either in T1 or T2 rectal carcinoma, histological differentiation is significantly related to the lymph node metastasis.
  • As radical resection achieve better survival than local resection, it should be suggested as the chief treatment for T1/T2 rectal carcinoma.
  • [MeSH-major] Carcinoma, Ductal / surgery. Lymph Nodes / pathology. Rectal Neoplasms / surgery. Rectum / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / radiotherapy. Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate

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  • (PMID = 16875615.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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96. Sultan I, Rodriguez-Galindo C, El-Taani H, Pastore G, Casanova M, Gallino G, Ferrari A: Distinct features of colorectal cancer in children and adolescents: a population-based study of 159 cases. Cancer; 2010 Feb 1;116(3):758-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: From January 1973 through December 2005, only 159 children/adolescents (ages 4-20 years) were reported with a diagnosis of colorectal cancer.
  • The most common sites of involvement were the rectum (27%) and the transverse colon (26%).
  • Adenocarcinoma was the most common histotype in both adults and pediatric patients; however, children/adolescents had more unfavorable histotypes (ie, mucinous adenocarcinoma [22%] and signet ring cell carcinoma [18%]) when compared with adults (10% and 1%, respectively; P < .001).
  • [MeSH-major] Colorectal Neoplasms / diagnosis

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  • [Copyright] Copyright 2009 American Cancer Society.
  • (PMID = 19957323.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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97. Agboola AO, Adekanmbi FA, Musa AA, Sotimehin AS, Deji-Agboola AM, Shonubi AM, Oyebadejo TY, Banjo AA: Pattern of childhood malignant tumours in a teaching hospital in south-western Nigeria. Med J Aust; 2009 Jan 5;190(1):12-4
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  • [Title] Pattern of childhood malignant tumours in a teaching hospital in south-western Nigeria.
  • OBJECTIVE: To document general baseline data on the patterns of childhood malignant tumours at a teaching hospital in south-western Nigeria.
  • RESULTS: 77 children were diagnosed with malignant tumours (an average of seven diagnoses per year); 46 were boys (60%), giving a male-to-female ratio of 1.5 : 1.
  • One case each of medullary thyroid carcinoma, adenocarcinoma of the rectum, invasive mucinous carcinoma of the colon were also identified.
  • CONCLUSION: These data suggest that Burkitt's lymphoma is the most common childhood malignant tumour in our geographic area of south-western Nigeria.

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  • (PMID = 19120001.001).
  • [ISSN] 0025-729X
  • [Journal-full-title] The Medical journal of Australia
  • [ISO-abbreviation] Med. J. Aust.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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98. Kim CW, Shin US, Yu CS, Kim JC: Clinicopathologic characteristics, surgical treatment and outcomes for splenic flexure colon cancer. Cancer Res Treat; 2010 Jun;42(2):69-76

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  • RESULTS: For the SF colon cancer patients, the proportion of males was higher than that for the right-sided colon patients or the sigmoid-descending junction & sigmoid (SD & S) colon patients (p≤=0.05, respectively) and the age at the time of diagnosis was younger (p≤=0.05).
  • The incidence of mucinous adenocarcinoma for the SF patients was similar to that for the patients with right-sided colon cancer, but it was higher than that for the patients with SD & S colon cancer (11.4% vs. 6.5%, p=0.248 or 2.5%, respectively, p=0.001).

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  • (PMID = 20622960.001).
  • [ISSN] 2005-9256
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2901086
  • [Keywords] NOTNLM ; Colectomy / Colonic neoplasms / Left colic flexure / Splenectomy
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99. Shirouzu K, Ogata Y: Histopathologic tumor spread in very low rectal cancer treated with abdominoperineal resection. Dis Colon Rectum; 2009 Nov;52(11):1887-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathologic tumor spread in very low rectal cancer treated with abdominoperineal resection.
  • PURPOSE: We have pathologically evaluated the tumor spread in low rectal cancer treated with abdominoperineal resection to clarify the potential indication of intersphincteric resection and other anus-preserving operations with external sphincter muscle resection.
  • A logistic regression analysis showed that the Pb-cancer, any distant metastasis, and the tumor histology of mucinous carcinoma were each an independent significant risk factor to invasion beyond the internal sphincter muscle, whereas the Pb-cancer, the poorly differentiated adenocarcinoma, and the mucinous carcinoma were each an independent significant risk factor to invasion into the intermuscular groove.
  • CONCLUSION: The anus-preserving operation with sphincter muscle resection was theoretically possible for low rectal cancer in patients who underwent abdominoperineal resection.
  • However, the procedure cannot be indicated for a tumor where the lowest edge is below the dentate line and where a preoperative biopsy shows a poorly differentiated adenocarcinoma or mucinous carcinoma, even if the intermuscular groove is macroscopically unaffected by the tumor.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Digestive System Surgical Procedures / methods. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Logistic Models. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm Staging. Registries. Risk Factors

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  • (PMID = 19966638.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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100. Xu AG, Jiang B, Zhong XH, Liu JH: [Clinical epidemiological characteristics of 3870 cases of colorectal cancers in Guangdong region]. Zhonghua Nei Ke Za Zhi; 2006 Jan;45(1):9-12
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  • With increase of age the number of cases with rectal cancers decreased gradually, while cancers occurring in the right hemi colon increased gradually.
  • 2243 (56.7%) lesions located in the rectum, 717 (18.1%) in the left hemi colon, 998 (25.2%) in the right hemi colon.
  • Histological types in all the lesions cases were grouped as follows: tubular adenocarcinoma 2943 (76.0%); papillary adenocarcinoma 256 (6.6%); mucinous carcinoma 425 (11.0%); and miscellaneous types 246 (6.4%).
  • CONCLUSIONS: The number of patients with colorectal cancer admitted in hospital increased gradually in the recent 20 years, and showed a trend with the decrease percentage in rectal cancer and the gradual increasing in right hemi colon cancer with increase of patients age.
  • Half of the colorectal cancer occurred in the rectum, the rest occurred in the left and right hemi colon.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adolescent. Adult. Age of Onset. Aged. Aged, 80 and over. Child. China / epidemiology. Female. Humans. Male. Middle Aged

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  • (PMID = 16624079.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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