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1. Dulucq JL, Wintringer P, Stabilini C, Mahajna A: Laparoscopic rectal resection with anal sphincter preservation for rectal cancer: long-term outcome. Surg Endosc; 2005 Nov;19(11):1468-74
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  • [Title] Laparoscopic rectal resection with anal sphincter preservation for rectal cancer: long-term outcome.
  • BACKGROUND: Total mesorectal excision (TME) is the surgical gold standard treatment for middle and low third rectal carcinoma.
  • The purposes of this study were to examine prospectively our experience with laparoscopic TME and high rectal resections, to evaluate the surgical outcomes and oncologic adequacy, and to discuss the role of this procedure in the treatment of rectal cancer.
  • METHODS: Between December 1992 and December 2004, all patients who underwent elective laparoscopic sphincter preserving rectal resection for rectal cancer were enrolled prospectively in this study.
  • CONCLUSION: Laparoscopic anterior resection and TME with anal sphincter preservation for rectal cancer is feasible and safe.
  • [MeSH-major] Laparoscopy. Rectal Neoplasms / surgery

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  • (PMID = 16222464.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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2. Kurtz MP, Heimann TM: Perineal adenocarcinoma thirty years after proctocolectomy: report of a case. Dis Colon Rectum; 2007 Dec;50(12):2241-3
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  • [Title] Perineal adenocarcinoma thirty years after proctocolectomy: report of a case.
  • This report describes an adenocarcinoma arising in the perineum 30 years after two-stage total proctocolectomy for ulcerative colitis.
  • This is one of the longest intervals reported between resection and presentation with cancer and also the only case in which the tumor is clearly free of association with existing bowel.
  • The mass originally presented as a perineal mucocele, an unusual complication of proctocolectomy for ulcerative colitis, and this is the first such mucocele to demonstrate malignant transformation.
  • [MeSH-major] Adenocarcinoma / diagnosis. Muscle Neoplasms / diagnosis. Perineum. Proctocolectomy, Restorative / adverse effects
  • [MeSH-minor] Biopsy. Colitis, Ulcerative / surgery. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Positron-Emission Tomography. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 17160573.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Lin GL, Meng WC, Lau PY, Qiu HZ, Yip AW: Local resection for early rectal tumours: Comparative study of transanal endoscopic microsurgery (TEM) versus posterior trans-sphincteric approach (Mason's operation). Asian J Surg; 2006 Oct;29(4):227-32
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  • [Title] Local resection for early rectal tumours: Comparative study of transanal endoscopic microsurgery (TEM) versus posterior trans-sphincteric approach (Mason's operation).
  • OBJECTIVE: To compare local resection of early rectal tumours by transanal endoscopic microsurgery (TEM) and the conventional posterior trans-sphincteric approach (Mason's operation).
  • METHODS: The study group comprised 31 consecutive patients with early rectal tumours (18 villous adenomas, 13 adenocarcinomas) who underwent TEM in Kwong Wah Hospital, Hong Kong.
  • The control group consisted of 51 patients with early rectal tumours (27 villous adenomas, 24 adenocarcinomas) who underwent Mason's operation in Peking Union Medical College Hospital, Beijing.
  • CONCLUSION: TEM is as effective as the conventional posterior trans-sphincteric approach (Mason's operation) for local curative resection of early rectal tumours.

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  • (PMID = 17098653.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
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4. Kanellos I, Zacharakis E, Kanellos D, Pramateftakis MG, Betsis D: Prognostic significance of CEA levels and positive cytology in peritoneal washings in patients with colorectal cancer. Colorectal Dis; 2006 Jun;8(5):436-40
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  • [Title] Prognostic significance of CEA levels and positive cytology in peritoneal washings in patients with colorectal cancer.
  • OBJECTIVE: The aims of this prospective study were to determine carcinoembryonic antigen (CEA) levels and incidence of cytology in peritoneal washings of patients with colorectal cancer, correlate the results with various histopathological factors and determine their significance as prognostic factors of the disease.
  • METHODS: From 1992 to 1999, 98 patients with adenocarcinoma of the colon or intraperitoneal rectum underwent curative surgery and enrolled in this study.
  • CONCLUSIONS: The presence of free malignant cells, as detected by cytology and CEA level, in the peritoneal cavity of patients with resectable colorectal cancer had no detectable impact on survival, hepatic metastases or local recurrence rate.
  • [MeSH-major] Carcinoembryonic Antigen / analysis. Colorectal Neoplasms / diagnosis. Peritoneal Lavage
  • [MeSH-minor] Aged. Colectomy. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Peritoneal Cavity / pathology. Prognosis. Sensitivity and Specificity. Survival Analysis. Treatment Outcome

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  • (PMID = 16684089.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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5. Tsamandas AC, Kardamakis D, Petsas T, Zolota V, Vassiliou V, Matatsoris T, Kalofonos H, Vagianos CE, Scopa CD: Bcl-2, bax and p53 expression in rectal adenocarcinoma. Correlation with classic pathologic prognostic factors and patients' outcome. In Vivo; 2007 Jan-Feb;21(1):113-8
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  • [Title] Bcl-2, bax and p53 expression in rectal adenocarcinoma. Correlation with classic pathologic prognostic factors and patients' outcome.
  • This study examined the bcl-2, bax and p53 expression in rectal adenocarcinomas and their relationship with tumor prognosis.
  • PATIENTS AND METHODS: Paraffin-embedded 4-microm tumor sections obtained from patients with rectal adenocarcinoma who underwent colectomy for therapeutic reasons, were analyzed with a standard streptavidin biotin peroxidase method, using polyclonal and monoclonal antibodies.
  • CONCLUSION: In rectal adenocarcinoma, bax and bcl-2 proteins co-express frequently with p53.
  • [MeSH-major] Adenocarcinoma / pathology. Proto-Oncogene Proteins c-bcl-2 / metabolism. Rectal Neoplasms / pathology. Tumor Suppressor Protein p53 / metabolism. bcl-2-Associated X Protein / metabolism
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Survival Rate

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  • [ErratumIn] In Vivo. 2007 May-Jun;21(3):553. Zolota, V [added]; Vassiliou, V [added]; Matatsoris, T [added]
  • [ErratumIn] In Vivo. 2007 Nov-Dec;21(6):1172
  • (PMID = 17354623.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein
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6. Zenda T, Masunaga T, Shinozaki K, Hashiba A, Fuwa B, Okada T, Minamoto T, Minato H: Primary minute invasive de novo colonic adenocarcinoma appearing as submucosal tumor. Int J Gastrointest Cancer; 2005;36(3):177-81
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  • [Title] Primary minute invasive de novo colonic adenocarcinoma appearing as submucosal tumor.
  • Because the lesion was unexpectedly suspicious for adenocarcinoma by pathological examination of the biopsy specimen, it was treated by endoscopic mucosal resection.
  • The specimen obtained demonstrated well-differentiated adenocarcinoma without any adenomatous element, and was located principally in the submucosal layer with a maximum depth of 1600 mum from the muscularis mucosae.
  • The cancer exposed to the luminal surface was pathologically concluded to be diminutive.
  • Because of deep submucosal infiltration and the latent aggressive nature of de novo cancer, the patient underwent an additional partial sigmoidcolectomy, which demonstrated no residual cancer and no regional lymph node metastasis.
  • The lesion in this patient exhibited a previously undescribed appearance of de novo colon cancer as submucosal tumor in an early phase of growth.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Gastroscopy. Humans. Intestinal Mucosa / pathology. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 16720914.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Joseph DA, Miller JW, Wu X, Chen VW, Morris CR, Goodman MT, Villalon-Gomez JM, Williams MA, Cress RD: Understanding the burden of human papillomavirus-associated anal cancers in the US. Cancer; 2008 Nov 15;113(10 Suppl):2892-900
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Anal cancer is an uncommon malignancy in the US; up to 93% of anal cancers are associated with human papillomavirus.
  • METHODS: Cases diagnosed between 1998 and 2003 from 39 population-based cancer registries were analyzed.
  • The following anal cancer histologies were included in the analysis: squamous cell, adenocarcinoma, and small cell/neuroendocrine carcinomas.
  • RESULTS: From 1998 through 2003, the annual age-adjusted invasive anal cancer incidence rate was 1.5 per 100,000 persons.
  • Squamous cell carcinoma (SCC) was the most common histology overall, accounting for 18,105 of 21,395 (84.6%) cases of anal cancer.
  • Continued surveillance and additional research are needed to assess the potential impact of the HPV vaccine on the anal cancer burden in the US.

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  • (PMID = 18980293.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] None / None / / N01 PC035137; United States / NCCDPHP CDC HHS / DP / U50 DP424071; United States / NCI NIH HHS / PC / N01 PC035137; United States / NCCDPHP CDC HHS / DP / U50 DP424071-04
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS104103; NLM/ PMC2729501
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8. Gasinska A, Skolyszewski J, Popiela T, Richter P, Darasz Z, Nowak K, Niemiec J, Biesaga B, Adamczyk A, Bucki K, Malecki K, Reinfuss M, Kowalska T: Bromodeoxyuridine labeling index as an indicator of early tumor response to preoperative radiotherapy in patients with rectal cancer. J Gastrointest Surg; 2007 Apr;11(4):520-8
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  • [Title] Bromodeoxyuridine labeling index as an indicator of early tumor response to preoperative radiotherapy in patients with rectal cancer.
  • PURPOSE: Assessment of tumor proliferation rate using Bromodeoxyuridine labeling index (BrdUrdLI) as a possible predictor of rectal cancer response to preoperative radiotherapy (RT).
  • [MeSH-major] Adenocarcinoma / radiotherapy. Bromodeoxyuridine. Neoadjuvant Therapy. Rectal Neoplasms / radiotherapy

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  • (PMID = 17436139.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] G34N38R2N1 / Bromodeoxyuridine
  • [Other-IDs] NLM/ PMC1852386
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9. Artifon EL, Sakai P, Ishioka S, Silva AF, Maluf F, Chaves D, Matuguma S, Pompeo A, Lucon AM, Srougi M, Bhutani MS: EUS for locoregional staging of prostate cancer--a pilot study. Gastrointest Endosc; 2007 Mar;65(3):440-7
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  • [Title] EUS for locoregional staging of prostate cancer--a pilot study.
  • BACKGROUND: This was a pilot study on EUS for locoregional evaluation of prostate cancer.
  • OBJECTIVE: Our purpose was to evaluate radial and linear-array EUS in locoregional prostate cancer staging.
  • DESIGN, SETTING, PATIENTS: From April to December 2005, 23 patients were referred to the Department of Urology with a confirmed or highly suspected diagnosis of prostate cancer on the basis of cytohistologic examination of fragments obtained by transrectal US-guided biopsy or transuretheral means.
  • INTERVENTION: An endosonographer and a radiologist with expertise in prostate imaging performed radial and linear EUS examinations without knowledge of the stage of prostate cancer of the referred patients.
  • Histopathologic study of the surgical specimen revealed adenocarcinoma in 20 of 23, atypical adenomatous hyperplasia in 2 of 23, and sclerosing adenosis in 1 of 23.
  • In 3 (3/23) patients EUS did not find a defined lesion, but the surgical specimen showed T1 stage cancer.
  • CONCLUSIONS: EUS presented high sensitivity, specificity, and accuracy for prostate cancer staging.
  • [MeSH-major] Adenocarcinoma / ultrasonography. Endosonography / methods. Prostatic Neoplasms / ultrasonography
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Equipment Design. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging / methods. Pilot Projects. Prostatectomy. Rectum. Retrospective Studies. Sensitivity and Specificity. Urethra

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  • (PMID = 17321246.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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10. Wang EL, Qian ZR, Nakasono M, Tanahashi T, Yoshimoto K, Bando Y, Kudo E, Shimada M, Sano T: High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. Br J Cancer; 2010 Mar 2;102(5):908-15
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  • [Title] High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer.
  • To demonstrate the role of TLR4 signalling in colon tumourigenesis, we examined the expression of TLR4 and myeloid differentiation factor 88 (MyD88) in colorectal cancer (CRC).
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Colorectal Neoplasms / metabolism. Liver Neoplasms / metabolism. Myeloid Differentiation Factor 88 / metabolism. Peritoneal Neoplasms / metabolism. Toll-Like Receptor 4 / metabolism
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Colon / metabolism. Colon / pathology. Female. Follow-Up Studies. Humans. Immunoenzyme Techniques. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Prognosis. Rectum / metabolism. Rectum / pathology. Survival Rate

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  • (PMID = 20145615.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MYD88 protein, human; 0 / Myeloid Differentiation Factor 88; 0 / TLR4 protein, human; 0 / Toll-Like Receptor 4
  • [Other-IDs] NLM/ PMC2833250
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11. Rengan R, Paty P, Wong WD, Guillem J, Weiser M, Temple L, Saltz L, Minsky BD: Distal cT2N0 rectal cancer: is there an alternative to abdominoperineal resection? J Clin Oncol; 2005 Aug 1;23(22):4905-12
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  • [Title] Distal cT2N0 rectal cancer: is there an alternative to abdominoperineal resection?
  • PURPOSE: Patients with cT2N0 distal rectal cancer do not require adjuvant therapy.
  • The purpose of this trial is to determine whether preoperative external-beam radiation therapy can increase the rate of sphincter preservation for patients with distal cT2N0 adenocarcinoma of the rectum.
  • PATIENTS AND METHODS: Between April 1988 and October 2003, 27 patients with distal rectal adenocarcinoma staged T2 by clinical and/or endorectal ultrasound who were judged by the operating surgeon to require an APR were treated with preoperative pelvic radiation alone (50.4 Gy).
  • Using the Memorial Sloan-Kettering Cancer Center sphincter function score, 54% of those undergoing a sphincter-sparing procedure had good/excellent bowel function at 12 to 24 months after surgery, and 77% had good/excellent function at 24 to 36 months after surgery.
  • CONCLUSION: Our data suggest that for patients with cT2N0 distal rectal cancer who require an APR, preoperative pelvic radiation improves sphincter preservation without an apparent compromise in local control or survival.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Anal Canal / surgery. Rectal Neoplasms / radiotherapy. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Colostomy. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Treatment Outcome

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  • (PMID = 16051945.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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12. Sasaki A, Iwashita Y, Shibata K, Matsumoto T, Ohta M, Kitano S: Analysis of preoperative prognostic factors for long-term survival after hepatic resection of liver metastasis of colorectal carcinoma. J Gastrointest Surg; 2005 Mar;9(3):374-80
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  • [Title] Analysis of preoperative prognostic factors for long-term survival after hepatic resection of liver metastasis of colorectal carcinoma.
  • Hepatic resection is the most effective therapy for liver metastasis of colorectal carcinoma.
  • To clarify indications for this therapy, the clinicopathologic and follow-up data of 103 consecutive patients who underwent hepatic resection for metastases of colorectal carcinoma were analyzed.
  • [MeSH-major] Adenocarcinoma / secondary. Cause of Death. Colorectal Neoplasms / mortality. Hepatectomy / mortality. Liver Neoplasms / secondary. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Analysis of Variance. Cohort Studies. Female. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Predictive Value of Tests. Preoperative Care / methods. Prognosis. Retrospective Studies. Risk Assessment. Survival Analysis. Time Factors. Treatment Outcome

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  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
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13. Glumpak Z, Zlojtro M, Mihaldinec Z, Pesek T, Lez C, Dominković A, Skrlec I: [Colorectal cancer in Krapina-Zagorje County: the Zabok General Hospital experience]. Acta Med Croatica; 2009 Oct;63(4):315-9
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  • [Title] [Colorectal cancer in Krapina-Zagorje County: the Zabok General Hospital experience].
  • AIM: To analyze data and current experience in diagnosing and treating colorectal cancer at Zabok General Hospital in Krapina-Zagorje County during a 5-year period (2002-2006).
  • METHODS: Retrospective study of 265 cases of colorectal carcinoma treated at Departments of Internal Medicine and of Abdominal Surgery, Zabok General Hospital, and analysis of epidemiological data obtained from the Croatian Public Health Institute for this County.
  • During the study period, the incidence rate was on a decrease and mortality rate increased, which could be attributed to the late diagnosis of this malignancy (3 months of the occurrence of the first alarming symptoms).
  • The most common symptoms were rectal bleeding, abdominal pain, anemia and changes in defecation habits.
  • The most common tumor seats were rectum and sigmoid colon.
  • Colorectal cancer was mostly diagnosed in an advanced stage of disease.
  • Histologic studies revealed adenocarcinoma in all but one case that proved to be lymphoma.
  • CONCLUSION: We conclude that Zabok General Hospital has valuable experience in diagnosing and treatment of colorectal cancer, with high rank performance since 68.0% of patients from Krapina-Zagorje County are managed at this hospital.

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  • (PMID = 20034332.001).
  • [ISSN] 1330-0164
  • [Journal-full-title] Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti
  • [ISO-abbreviation] Acta Med Croatica
  • [Language] hrv
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Croatia
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14. Sharma S, Gupta R, Sharma R, Kotru M: Mucin-secreting gastric adenocarcinoma with Rhabdoid areas. Saudi J Gastroenterol; 2010 Jan-Mar;16(1):46-8
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  • [Title] Mucin-secreting gastric adenocarcinoma with Rhabdoid areas.
  • In this report, we describe the case of a 40-year-old patient with gastric adenocarcinoma composed of histologically well-differentiated glandular areas and focal rhabdoid zones.
  • [MeSH-major] Adenocarcinoma / pathology. Neoplasms, Multiple Primary. Rhabdoid Tumor / pathology. Stomach Neoplasms / pathology

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15. Vainer G, Vainer-Mosse E, Pikarsky A, Shenoy SM, Oberman F, Yeffet A, Singer RH, Pikarsky E, Yisraeli JK: A role for VICKZ proteins in the progression of colorectal carcinomas: regulating lamellipodia formation. J Pathol; 2008 Aug;215(4):445-56
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  • We hypothesized that VICKZ proteins may play a role in cancer cell migration.

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  • [Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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  • (PMID = 18535985.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / R01 AR041480-13; United States / NIGMS NIH HHS / GM / R01 GM084364-17; United States / NIAMS NIH HHS / AR / R01 AR041480-11; United States / NIAMS NIH HHS / AR / AR041480-06; United States / NIAMS NIH HHS / AR / AR041480-11; United States / NIGMS NIH HHS / GM / R01 GM084364-15A1; United States / NIAMS NIH HHS / AR / R01 AR041480-10A2; United States / NIAMS NIH HHS / AR / AR041480-10A2; United States / NIAMS NIH HHS / AR / AR041480-09; United States / NIAMS NIH HHS / AR / R01 AR041480; United States / NIGMS NIH HHS / GM / R01 GM084364-18; United States / NIAMS NIH HHS / AR / R01 AR041480-09; United States / NIAMS NIH HHS / AR / AR041480-08; United States / NIAMS NIH HHS / AR / R01 AR041480-06; United States / NIAMS NIH HHS / AR / R01 AR041480-14; United States / NIGMS NIH HHS / GM / R01 GM084364-16; United States / NIAMS NIH HHS / AR / R01 AR041480-08; United States / NIAMS NIH HHS / AR / R01 AR041480-11S1; United States / NIAMS NIH HHS / AR / R01 AR041480-12; United States / NIGMS NIH HHS / GM / R01 GM084364
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / ZBP1 protein, human
  • [Other-IDs] NLM/ NIHMS314194; NLM/ PMC3148580
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16. Slosar M, Vohra P, Prasad M, Fischer A, Quinlan R, Khan A: Insulin-like growth factor mRNA binding protein 3 (IMP3) is differentially expressed in benign and malignant follicular patterned thyroid tumors. Endocr Pathol; 2009;20(3):149-57
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  • [Title] Insulin-like growth factor mRNA binding protein 3 (IMP3) is differentially expressed in benign and malignant follicular patterned thyroid tumors.
  • It is highly expressed in carcinomas of the pancreas, stomach, colon, rectum, kidneys, uterine cervix, lung, and ovary.
  • We immunostained 219 thyroid lesions selected from our surgical pathology archives including 14 hyperplastic colloid nodules (CN), 19 Hashimoto's thyroiditis (HT), two Graves disease (GD), ten Hürthle cell adenoma (HCA), 20 follicular adenoma (FA), 37 conventional papillary thyroid carcinoma (PTC), 60 follicular variant of papillary carcinoma (FVPC), 19 Hürthle cell carcinoma (HCC), 32 follicular carcinoma (FC), and six poorly differentiated/anaplastic carcinoma.
  • No significant correlation was found between pathologic tumor characteristics and IMP3 expression in differentiated follicular pattern thyroid carcinoma.
  • With 100% specificity and 69% sensitivity for FC as compared to FA and 100% specificity for FVPC, again compared to FA, IMP3 has the potential to be diagnostically useful in differentiating malignant and benign follicular pattern thyroid lesions.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Biomarkers, Tumor / analysis. Neoplasm Proteins / biosynthesis. RNA-Binding Proteins / biosynthesis. Thyroid Neoplasms / pathology

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  • (PMID = 19449140.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / IMP3 protein, human; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA-Binding Proteins
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17. Suciu-Foca N, Feirt N, Zhang QY, Vlad G, Liu Z, Lin H, Chang CC, Ho EK, Colovai AI, Kaufman H, D'Agati VD, Thaker HM, Remotti H, Galluzzo S, Cinti P, Rabitti C, Allendorf J, Chabot J, Caricato M, Coppola R, Berloco P, Cortesini R: Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients. J Immunol; 2007 Jun 1;178(11):7432-41
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  • [Title] Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients.
  • Furthermore, we found that patients with melanoma, and carcinomas of the colon, rectum, and pancreas produce the soluble ILT3 protein, which induces the differentiation of CD8(+) T suppressor cells and impairs T cell responses in MLC.
  • These data suggest that ILT3 depletion or blockade is crucial to the success of immunotherapy in cancer.
  • [MeSH-major] Adenocarcinoma / immunology. Colorectal Neoplasms / immunology. Graft Rejection / immunology. Graft Rejection / prevention & control. Melanoma / immunology. Pancreatic Neoplasms / immunology. Receptors, Cell Surface / physiology. T-Lymphocytes, Regulatory / immunology

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  • (PMID = 17513794.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI55234-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / LILRB4 protein, human; 0 / Membrane Proteins; 0 / Receptors, Cell Surface
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18. Bellomi M, Petralia G, Sonzogni A, Zampino MG, Rocca A: CT perfusion for the monitoring of neoadjuvant chemotherapy and radiation therapy in rectal carcinoma: initial experience. Radiology; 2007 Aug;244(2):486-93
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  • [Title] CT perfusion for the monitoring of neoadjuvant chemotherapy and radiation therapy in rectal carcinoma: initial experience.
  • PURPOSE: To prospectively monitor changes in rectal cancer perfusion after combined neoadjuvant chemotherapy and radiation therapy with perfusion computed tomography (CT) and to evaluate whether perfusion CT findings correlate with response to therapy.
  • Twenty-five patients with rectal adenocarcinoma (18 men, seven women; age range, 42-72 years; mean age, 61.3 years) underwent perfusion CT; all of them underwent neoadjuvant chemotherapy and radiation therapy, followed by surgery.
  • Blood flow (BF), blood volume (BV), mean transit time, and permeability-surface area product (PS) were computed in the tumor and in normal rectal wall by two independent blinded radiologists.
  • RESULTS: BF, BV, and PS were significantly higher in rectal cancer than in normal rectal wall (P < .001).
  • CONCLUSION: Perfusion CT has potential for monitoring the effects of combined neoadjuvant chemotherapy and radiation therapy and predicting the response of rectal cancer to such therapy.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Rectal Neoplasms / drug therapy. Rectal Neoplasms / radiotherapy. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Image Processing, Computer-Assisted. Male. Middle Aged. Neoadjuvant Therapy. Rectum / blood supply. Statistics, Nonparametric. Treatment Outcome

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  • (PMID = 17641369.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Wang Y, Cummings B, Catton P, Dawson L, Kim J, Ringash J, Wong R, Yi QL, Brierley J: Primary radical external beam radiotherapy of rectal adenocarcinoma: long term outcome of 271 patients. Radiother Oncol; 2005 Nov;77(2):126-32
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  • [Title] Primary radical external beam radiotherapy of rectal adenocarcinoma: long term outcome of 271 patients.
  • BACKGROUND AND PURPOSE: To assess local control, survival and toxicity following primary radical external beam radiotherapy of rectal adenocarcinoma treated between 1978 and 1997, and to compare practices and outcomes between the two decades of study.
  • For patients with mobile, partially fixed and fixed tumors, overall 5 year survival was 48, 26 and 6%, respectively, and cancer specific 5 year survival was 59, 33 and 9%, respectively.
  • CONCLUSIONS: Radical external beam radiotherapy is a reasonable treatment option for rectal carcinoma for patients who are not surgical candidates or refuse surgery.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / radiotherapy. Radiotherapy, High-Energy / methods. Rectal Neoplasms / mortality. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Biopsy, Needle. Chi-Square Distribution. Dose-Response Relationship, Radiation. Female. Follow-Up Studies. Humans. Immunohistochemistry. Logistic Models. Male. Middle Aged. Neoplasm Staging. Probability. Radiation Dosage. Retrospective Studies. Risk Assessment. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 16216364.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
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20. Scudiere JR, Shi C, Hruban RH, Herman JM, Fishman EK, Schulick RD, Wolfgang CL, Makary MA, Thornton K, Montgomery E, Horton KM: Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancer. Am J Surg Pathol; 2010 Apr;34(4):447-53
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  • [Title] Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancer.
  • When SM does involve the pancreas, it can mimic pancreatic carcinoma both clinically and radiographically with pain, obstructive jaundice, a mass lesion, and even the appearance of vascular invasion.
  • Five of these 6 patients were originally thought to have a primary pancreatic neoplasm.
  • A dramatic response to immunosuppressive therapy is illustrated by the case of a 46-year-old woman who presented with the presumptive diagnosis of an unresectable pancreatic cancer.
  • Distinguishing SM from pancreatic carcinoma is crucial to appropriate management, as patients with SM may benefit from immunosuppressive therapy.

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  • (PMID = 20351487.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA062924-149002; United States / NCI NIH HHS / CA / P50 CA062924; United States / NCI NIH HHS / CA / CA62924; United States / NCI NIH HHS / CA / P50 CA062924-149002
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 094ZI81Y45 / Tamoxifen
  • [Other-IDs] NLM/ NIHMS181132; NLM/ PMC2861335
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21. Skalický T, Treska V, Spidlen V, Vodicka V, Sutnar A, Liska V, Klecka J, Simánek V, Safránek J, Fichtl J, Polák M: [Surgical treatment of liver and pulmonary metastases of colorectal carcinoma]. Rozhl Chir; 2010 Apr;89(4):253-5
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  • [Title] [Surgical treatment of liver and pulmonary metastases of colorectal carcinoma].
  • THE AIM: The aim of the work was to evaluate the set of 10 patients, who were operated on hepatic and pulmonary metastases of colorectal carcinoma at the Surgical Clinic of Medical Faculty of Charles University and Faculty Hospital in Plzeń in years from 2005 till 2009.
  • THE SET OF THE PATIENTS: In years from 2005 till 12/2009 we operated 10 patients during whose affection there occurred hepatic and pulmonary metastases of colorectal carcinoma and these were solved surgically.
  • In 10% it was hepatic resection in the first period after the operation of primary carcinoma, it was the first performance on the hepatic parenchyma in 90%.
  • In 4 cases primary carcinoma was in the rectum and in 6 cases in the large intestine.
  • Rectal carcinoma spread into lungs in 50%.
  • An average time of a 5-year survival in the patients after resection of hepatic and pulmonary metastases of colorectal carcinoma was 26%.
  • THE CONCLUSION: Hepatic and pulmonary resection in the selected patients with generalized colorectal carcinoma extends the period of a survival and does not worsen the quality of the life.
  • [MeSH-major] Carcinoma / secondary. Carcinoma / surgery. Colorectal Neoplasms / pathology. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Lung Neoplasms / secondary. Lung Neoplasms / surgery

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  • (PMID = 20586164.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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22. Rouanet P: [Preoperative treatment impact for ultralow rectal carcinoma sphincter preservation]. Cancer Radiother; 2006 Nov;10(6-7):451-5
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  • [Title] [Preoperative treatment impact for ultralow rectal carcinoma sphincter preservation].
  • [Transliterated title] Impact des traitements préopératoires (radiothérapie et chimiothérapie) dans la conservation sphinctérienne des cancers du très bas rectum.
  • Sphincter preservation for low rectal carcinoma must be evaluated with a plurifactoriel approach.
  • [MeSH-major] Limb Salvage. Reconstructive Surgical Procedures / methods. Rectum

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  • (PMID = 17005428.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 23
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23. Bondar' GV, Dumanskiĭ IuV, Basheev VKh, Adamchuk GA, Zolotukhin SE: [Immediate results of transabdominal rectal resection with the duplicature anastomosis formation]. Klin Khir; 2005 Feb;(2):17-9
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  • [Title] [Immediate results of transabdominal rectal resection with the duplicature anastomosis formation].
  • There were presented immediate results of surgical treatment of 425 patients with the upper ampullar and rectosygmoid portion cancer recti (CR), to whom in 1989-2002 transabdominal rectal resection, using the duplicature anastomosis, was performed.
  • In 93.4% of observations, according to histological investigation data, adenocarcinoma was diagnosed.

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  • (PMID = 15903218.001).
  • [ISSN] 0023-2130
  • [Journal-full-title] Klinichna khirurhiia
  • [ISO-abbreviation] Klin Khir
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Ukraine
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24. Yano H, Saito Y, Kirihara Y, Takashima J: Tumor invasion of lymph node capsules in patients with Dukes C colorectal adenocarcinoma. Dis Colon Rectum; 2006 Dec;49(12):1867-77
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  • [Title] Tumor invasion of lymph node capsules in patients with Dukes C colorectal adenocarcinoma.
  • PURPOSE: The objective of this study was to investigate the correlation between the microscopic findings of positive lymph nodes, especially focusing on capsular invasion, and the outcome after curative surgical resection of colorectal cancer.
  • METHODS: We analyzed 480 positive lymph nodes from 155 consecutive patients with Stage III colorectal cancer to determine the frequency and significance of lymph node capsular invasion.
  • Recurrence-free and cancer-specific survival rates were assessed in the patients with and without lymph node capsular invasion.
  • RESULTS: Between April 1995 and December 2000, 406 consecutive patients with primary colorectal cancer underwent curative resection.
  • During the median follow-up period of 4.8 years, 41 patients (26.5 percent) developed recurrent disease and 28 patients died of cancer.
  • CONCLUSIONS: Lymph node capsular invasion, determined by routine hematoxylin-eosin staining, is a potent prognostic factor in Stage III colorectal cancer.
  • [MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Lymph Nodes / pathology
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Multivariate Analysis. Neoplasm Invasiveness. Neoplasm Recurrence, Local

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  • [CommentIn] Dis Colon Rectum. 2007 Sep;50(9):1484; author reply 1484-5 [17661142.001]
  • (PMID = 17080279.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Kuwabara M, Wada K, Maeda Y, Miyazaki A, Tsunemitsu H: First isolation of cytopathogenic bovine torovirus in cell culture from a calf with diarrhea. Clin Vaccine Immunol; 2007 Aug;14(8):998-1004
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  • A cytopathogenic virus (designated the Aichi/2004 strain) was isolated in a human rectal adenocarcinoma cell line (HRT-18) from the ileum contents of a calf with diarrhea.

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  • (PMID = 17567770.001).
  • [ISSN] 1556-6811
  • [Journal-full-title] Clinical and vaccine immunology : CVI
  • [ISO-abbreviation] Clin. Vaccine Immunol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AB285125/ AB285126/ AB285127
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / DNA, Viral; 0 / Viral Proteins
  • [Other-IDs] NLM/ PMC2044491
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26. Saad RS, Silverman JF, Khalifa MA, Rowsell C: CDX2, cytokeratins 7 and 20 immunoreactivity in rectal adenocarcinoma. Appl Immunohistochem Mol Morphol; 2009 May;17(3):196-201
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  • [Title] CDX2, cytokeratins 7 and 20 immunoreactivity in rectal adenocarcinoma.
  • There are limited data regarding CDX2 expression in rectal carcinoma.
  • The CK20/CK7 immunoprofile of colorectal adenocarcinoma has been described in studies, which have mostly lumped colonic and rectal tumors together.
  • In this study, we investigated the diagnostic utility of immunohistochemical stains for CK7, CK20, and CDX2 in a series of rectal adenocarcinoma.
  • Fifty-five specimens of rectal adenocarcinomas were retrieved and immunostained for CK7 (Dako-M7018), CK20 (NovoCastra NCL-L-CK20), and CDX2 (NovoCastra NCL-CDX2).
  • Thirty cases of pancreatic adenocarcinoma and 15 cholangiocarcinomas were also studied as a comparison group.
  • CK7 was expressed in 12/55 (22%) and CK20 in 48/55 (87%) cases of rectal adenocarcinoma.
  • The CK7-/CK20+ immunophenotype was identified in 36/55 (65%), CK7+/CK20+ in 12/55 (22%), and CK7-/CK20- in 7/55 (13%) rectal adenocarcinoma.
  • Benign rectal mucosa was available in 37 cases and showed the following results: CK7-/CK20+ in 25/37 (67%), CK7+/CK20+ in 8/37 (22%) and CK7-/CK20- in 4/37 (11%) cases.
  • In conclusion, CK7 can be expressed in rectal adenocarcinoma, and should not be used as the sole basis for excluding a rectal primary.
  • CDX2 is a sensitive marker for rectal origin of adenocarcinoma.
  • It can be helpful in cases with metastatic rectal carcinoma, especially those with CK7+/CK20+ or CK20-/CK7- immunophenotype.
  • In this study, CDX2 expression was not influenced by the grade (differentiation) of rectal adenocarcinoma.

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  • [ErratumIn] Appl Immunohistochem Mol Morphol. 2009 Oct;17(5):464
  • (PMID = 19098678.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Keratin-7
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27. Hwang HJ, Song KH, Youn YH, Kwon JE, Kim H, Chung JB, Lee YC: A case of more abundant and dysplastic adenomas in the interposed colon than in the native colon. Yonsei Med J; 2007 Dec 31;48(6):1075-8
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  • We report a 60-year-old woman with intramucosal adenocarcinoma arising in the interposed colon, 40 years after the esophageal reconstruction for lye induced esophageal stricture.
  • Although synchronous adenomas were also found in the native colon where the graft was taken, the number of adenomas was greater in the interposed colon and more dysplastic, even progressed to adenocarcinoma, than that of the native colon.
  • The microsatellite instability-testing performed in the intramucosal carcinoma from interposed colon showed absence of microsatellite instability.
  • Changing of location and functional demand of colonic segment, and the exposure to different intraluminal contents might have facilitated the adenoma- carcinoma transformation in the interposed colon.
  • [MeSH-minor] Adenocarcinoma / pathology. Disease Progression. Esophagoplasty / adverse effects. Esophagoplasty / methods. Female. Humans. Middle Aged. Postoperative Complications / etiology. Postoperative Complications / pathology. Time Factors

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  • [Cites] Gastrointest Endosc. 1999 Dec;50(6):852-4 [10570353.001]
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  • (PMID = 18159607.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2628170
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28. Freeman HJ, Webber DL: Perivascular epithelioid cell neoplasm of the colon. World J Gastrointest Oncol; 2010 Apr 15;2(4):205-8
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  • [Title] Perivascular epithelioid cell neoplasm of the colon.
  • A 17-year-old female presented with rectal bleeding from an ulcerated sigmoid mass in 1994.
  • Initial pathological evaluation revealed a rare clear cell neoplasm of the colon, possibly originating from kidneys, adrenals, lung or a gynecologic source as a metastatic lesion.
  • The original resected neoplasm was reviewed and re-classified as a perivascular epithelioid cell neoplasm (PEComa).
  • Although the long-term natural history of PEComas requires definition, increased clinical and pathological awareness should lead to increased recognition of an apparently rare type of colonic neoplasm that likely occurs more often than is currently appreciated.

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  • (PMID = 21160599.001).
  • [ISSN] 1948-5204
  • [Journal-full-title] World journal of gastrointestinal oncology
  • [ISO-abbreviation] World J Gastrointest Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999178
  • [Keywords] NOTNLM ; Carcinoid tumor / Clear cell tumor / Colonic adenocarcinoma / Perivascular epithelioid cell neoplasm
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29. Göhl J, Hohenberger W, Merkel S: Lymph node dissection in rectal carcinoma: TME and what else? Onkologie; 2009 Feb;32(1-2):57-61
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  • [Title] Lymph node dissection in rectal carcinoma: TME and what else?
  • Total mesorectal excision (TME) has been established as a standardized radical surgical procedure in malignant tumors of the middle and lower rectal third.
  • In carcinomas of the upper rectal third, TME is seen as controversial.
  • Total mesorectal excision in the radical surgical treatment of lower and middle third rectal carcinomas is the essential part of lymphatic dissection in these tumors.
  • [MeSH-major] Digestive System Surgical Procedures / methods. Lymph Node Excision / methods. Rectal Neoplasms / surgery

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  • [Copyright] Copyright (c) 2009 S. Karger AG, Basel.
  • (PMID = 19209023.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 44
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30. McHugh SM, O'Donnell J, Gillen P: Synchronous association of rectal adenocarcinoma and three ileal carcinoids: a case report. World J Surg Oncol; 2009;7:21
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  • [Title] Synchronous association of rectal adenocarcinoma and three ileal carcinoids: a case report.
  • BACKGROUND: Synchronous midgut carcinoids with gastrointestinal adenocarcinoma are a rare but recognised association.
  • CASE PRESENTATION: The patient, a 74 year old woman, underwent anterior resection for a low rectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoid Tumor / pathology. Ileal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Rectal Neoplasms / pathology

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  • (PMID = 19228386.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2649932
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31. Chaleoykitti B: Comparative study between preoperative and postoperative histologic grading in adenocarcinoma of the colon and rectum. J Med Assoc Thai; 2005 Nov;88(11):1535-9
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  • [Title] Comparative study between preoperative and postoperative histologic grading in adenocarcinoma of the colon and rectum.
  • BACKGROUND: Preoperative histologic grading was used to decide the length of the margin of resection in adenocarcinoma of colon and rectum.
  • MATERIAL AND METHOD: Preoperative and postoperative histologic grading of patients with adenocarcinoma of the colon and rectum in the department of surgery, Phramongkutklao Hospital between January 1999 and October 2004 were collected and compared together using percentage and chi-square test.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Neoplasm Staging / standards. Postoperative Care / standards. Preoperative Care / standards. Rectal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colonoscopy. Colorectal Surgery / methods. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 16471098.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Thailand
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32. Sadahiro S, Suzuki T, Maeda Y, Tanaka Y, Nakamura T, Saguchi T, Yasuda S, Makuuchi H, Murayama C, Ohizumi Y: Predictors of tumor downsizing and regression with preoperative radiotherapy alone and with concomitant tegafur/uracil (UFT) for resectable advanced rectal adenocarcinoma. Hepatogastroenterology; 2007 Jun;54(76):1107-12
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  • [Title] Predictors of tumor downsizing and regression with preoperative radiotherapy alone and with concomitant tegafur/uracil (UFT) for resectable advanced rectal adenocarcinoma.
  • This study attempts to evaluate retrospectively the significance of apoptosis-related and proliferative indexes in biopsy specimens obtained before treatment as predictors of sensitivity to RT or to CRT for locally advanced rectal adenocarcinoma.
  • METHODOLOGY: The subjects were 96 patients with clinical T3-4/Nx/M0 adenocarcinoma of the middle third or lower third of the rectum.
  • RESULTS: AI-positivity, p53-negativity, p21-positivity and well differentiated adenocarcinoma were predictors of high sensitivity in RT group, whereas AI-positivity alone was the predictor in CRT group.
  • The addition of UFT to RT increased sensitivity in patients with p53-positivity, p21-negativity and moderately differentiated adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Biomarkers, Tumor / analysis. Drug Resistance, Neoplasm. Radiation Tolerance. Rectal Neoplasms / therapy

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  • (PMID = 17629049.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 1-UFT protocol
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33. Chen CC, Lee RC, Lin JK, Wang LW, Yang SH: How accurate is magnetic resonance imaging in restaging rectal cancer in patients receiving preoperative combined chemoradiotherapy? Dis Colon Rectum; 2005 Apr;48(4):722-8
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  • [Title] How accurate is magnetic resonance imaging in restaging rectal cancer in patients receiving preoperative combined chemoradiotherapy?
  • PURPOSE: Preoperative combined chemoradiotherapy is currently the main neoadjuvant therapy used to treat locally advanced middle and low rectal adenocarcinoma.
  • METHODS: Between August 2000 and June 2003, 50 patients with biopsy-proven middle and lower rectal adenocarcinoma, with initial stage T3-T4 or N+, M0, were recruited in this series.
  • [MeSH-major] Adenocarcinoma / pathology. Magnetic Resonance Imaging / standards. Neoplasm Staging / methods. Rectal Neoplasms / pathology

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  • (PMID = 15747073.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 56HH86ZVCT / Uracil; U3P01618RT / Fluorouracil
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34. Kurt M, Ozkan L, Kurt E, Cetintas SK, Aygun S, Ercan I, Yilmazlar T, Memik F: Comparison of protracted infusion 5-fluorouracil and capecitabine in adjuvant chemoradiotherapy for rectal cancer. Hepatogastroenterology; 2008 Jul-Aug;55(85):1158-63
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  • [Title] Comparison of protracted infusion 5-fluorouracil and capecitabine in adjuvant chemoradiotherapy for rectal cancer.
  • BACKGROUND/AIMS: 5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant treatment of rectal cancer.
  • METHODOLOGY: Patients with stage II and stage III rectal adenocarcinoma, who were included in this analysis, received adjuvant chemoradiotherapy consisting of external-beam radiotherapy (50.4-54Gy) either with 5-Fluorouracil at a median dose of 300 mg/m2/day by protracted venous infusion for 5 days a week, or capecitabine at a median dose of 1650 mg/m2/day for 5 days a week after surgery.
  • CONCLUSIONS: Capecitabine is at least as effective as 5-Fluorouracil in the postoperative treatment of rectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / therapy. Antimetabolites, Antineoplastic / administration & dosage. Deoxycytidine / analogs & derivatives. Fluorouracil / administration & dosage. Fluorouracil / analogs & derivatives. Rectal Neoplasms / therapy

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  • (PMID = 18795649.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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35. Stojanović I, Karamehmedović Z, Elgazwi K, Baća I: Laparoscopic treatment of cystadenocarcinoma of the appendix penetrating in the sigmoid colon. JSLS; 2009 Jul-Sep;13(3):445-9
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  • Adenocarcinoma of the vermiform appendix is a rare neoplasm of the gastrointestinal tract that most commonly presents as right lower abdominal pain, mimicking acute appendicitis.
  • An accurate and complete preoperative diagnosis has been rare in the past; however, modern imaging techniques allow recognition of most complications and associated conditions.
  • The diagnosis is confirmed postoperatively.
  • Aggressive surgical management is the treatment of choice in appendicular adenocarcinoma.

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  • (PMID = 19793493.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ PMC3015953
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36. Matsuoka H, Nakamura A, Masaki T, Sugiyama M, Nitatori T, Ohkura Y, Sakamoto A, Atomi Y: Optimal diagnostic criteria for lateral pelvic lymph node metastasis in rectal carcinoma. Anticancer Res; 2007 Sep-Oct;27(5B):3529-33
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  • [Title] Optimal diagnostic criteria for lateral pelvic lymph node metastasis in rectal carcinoma.
  • AIM: The purpose of this study was to determine the optimal diagnostic criteria for lateral pelvic lymph node metastasis in patients with rectal carcinoma.
  • PATIENTS AND METHODS: From July 1997 to June 2005, fifty-one patients with locally advanced middle or lower rectal carcinoma underwent preoperative MRI examination, followed by total mesorectal excision with lateral pelvic node dissection.
  • CONCLUSION: An ovoid shape with a transverse axis diameter of 5 mm or larger on MRI was considered as the optimal criterion for diagnosing lateral lymph node metastasis in patients with rectal carcinoma.
  • [MeSH-major] Lymph Nodes / pathology. Pelvic Neoplasms / pathology. Rectal Neoplasms / diagnosis. Rectal Neoplasms / secondary

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  • (PMID = 17972513.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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37. Wind J, Bemelman WA: Re: tumor invasion of lymph node capsules in patients with Dukes C colorectal adenocarcinoma. Dis Colon Rectum; 2007 Sep;50(9):1484; author reply 1484-5
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  • [Title] Re: tumor invasion of lymph node capsules in patients with Dukes C colorectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Lymph Nodes / pathology
  • [MeSH-minor] Humans. Neoplasm Invasiveness. Neoplasm Staging

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  • [CommentOn] Dis Colon Rectum. 2006 Dec;49(12):1867-77 [17080279.001]
  • (PMID = 17661142.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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38. Wolberink SV, Beets-Tan RG, de Haas-Kock DF, van de Jagt EJ, Span MM, Wiggers T: Multislice CT as a primary screening tool for the prediction of an involved mesorectal fascia and distant metastases in primary rectal cancer: a multicenter study. Dis Colon Rectum; 2009 May;52(5):928-34
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  • [Title] Multislice CT as a primary screening tool for the prediction of an involved mesorectal fascia and distant metastases in primary rectal cancer: a multicenter study.
  • METHODS: A total of 250 patients with adenocarcinoma of the rectum underwent multislice CT scans of the chest and abdomen before undergoing total mesorectal excision.
  • The overall sensitivity for mid-/high rectal tumors was 76.1 percent and the overall specificity was 96.3 percent.
  • CONCLUSIONS: Multislice CT can be used for the assessment of mesorectal fascia involvement in primary rectal cancer, especially those located in the middle rectum and the high rectum; however, in the prediction of an involved margin of tumors located in the distal rectum, the accuracy of multislice CT falls short.
  • [MeSH-major] Adenocarcinoma / pathology. Fascia / pathology. Liver Neoplasms / diagnosis. Lymphatic Metastasis / diagnosis. Rectal Neoplasms / pathology. Tomography, X-Ray Computed / methods

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  • (PMID = 19502858.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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39. Vagliasindi A, Teodorani N, Palazzi S, Mura G, Framarini M, Mazza P, Datiti A, Rosetti P, Curcio A, Verdecchia GM: [Neoadjuvant radiochemotherapy of rectal carcinoma: retrospective analysis of a personal experience]. Suppl Tumori; 2005 May-Jun;4(3):S24-5
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  • [Title] [Neoadjuvant radiochemotherapy of rectal carcinoma: retrospective analysis of a personal experience].
  • [Transliterated title] Radiochemioterapia neoadiuvante nel carcinoma del retto analisi retrospettiva di un'esperienza personale.
  • Even if surgical resection continues to be the mainstay of treatment in rectal cancer, preoperative chemoradiation may downstage locally advanced rectal cancer, in some cases with no residual tumors.
  • Compared with surgery alone, preoperative radiotherapy and chemotherapy improves outcomes in patients with locally advanced rectal cancer.
  • In the present review we summarize the results of preoperative chemoradiation therapy in a group of 15 patients who underwent surgical resection with total mesorectal excision (TME) for advanced mid and low rectal cancer from February 2002 to February 2004.
  • [MeSH-major] Rectal Neoplasms / therapy

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  • (PMID = 16437881.001).
  • [ISSN] 2283-5423
  • [Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
  • [ISO-abbreviation] Suppl Tumori
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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40. Chong VH, Abdullah MS, Telisinghe PU, Jalihal A: Colorectal cancer: incidence and trend in Brunei Darussalam. Singapore Med J; 2009 Nov;50(11):1085-9
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  • [Title] Colorectal cancer: incidence and trend in Brunei Darussalam.
  • INTRODUCTION: The incidence of colorectal cancer (CRC) is reported to be increasing.
  • METHODS: All histologically-confirmed CRCs over a 22-year period (1986-2007) were identified from the National Cancer and the Department of Pathology registries and retrospectively reviewed.
  • RESULTS: There was a total of 576 (male 59.0 percent, mean age 59.6 +/- 14.8 years, adenocarcinoma 97.6 percent, rectum 31.4 percent) CRCs diagnosed during this period.
  • There was an increasing trend in the mean age at diagnosis, 55.2 +/- 17.5 years in 1986 to 62.0 +/- 13.0 years in 2007, but this was not significant (p-value equals 0.150, ANOVA).
  • There was no difference in the age at diagnosis between the genders (p-value equals to 0.432) and tumour sites, colon vs. rectum (p-value equals to 0.279).
  • The mean age of the Chinese (62.6 +/- 14.0 years) was significantly higher than that of the Malays (58.2 +/- 14.9 years, p-value equals to 0.001) at diagnosis.
  • [MeSH-major] Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology

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  • (PMID = 19960165.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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41. Gaertner WB, Hagerman GF, Finne CO, Alavi K, Jessurun J, Rothenberger DA, Madoff RD: Fistula-associated anal adenocarcinoma: good results with aggressive therapy. Dis Colon Rectum; 2008 Jul;51(7):1061-7
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  • [Title] Fistula-associated anal adenocarcinoma: good results with aggressive therapy.
  • PURPOSE: To evaluate the clinical features, pathology, treatment, and outcome of patients with fistula-associated anal adenocarcinoma.
  • METHODS: We identified 14 patients with histologically proven fistula-associated anal adenocarcinoma.
  • The average age at time of diagnosis was 59 (range, 37-76) years.
  • The diagnosis of cancer was suspected during physical examination in 6 of the 14 patients (43 percent).
  • CONCLUSIONS: The diagnosis of fistula-associated anal adenocarcinoma is often unsuspected.
  • [MeSH-major] Adenocarcinoma / therapy. Rectal Fistula / therapy. Rectal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Biopsy. Digestive System Surgical Procedures / methods. Drainage / methods. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoadjuvant Therapy / methods. Neoplasm Staging. Retrospective Studies. Time Factors. Treatment Outcome. Urogenital Surgical Procedures / methods

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  • (PMID = 18418652.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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42. Diaz-Sanchez A, Nuñez-Martinez O, Gonzalez-Asanza C, Matilla A, Merino B, Rincon D, Beceiro I, Catalina MV, Salcedo M, Bañares R, Clemente G: Portal hypertensive colopathy is associated with portal hypertension severity in cirrhotic patients. World J Gastroenterol; 2009 Oct 14;15(38):4781-7
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  • One asymptomatic patient had a well-differentiated adenocarcinoma.
  • Preneoplastic polyps and neoplasm (P = 0.02) and spontaneous bacterial peritonitis (P = 0.006) were more prevalent in patients with colopathy.

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43. Winder T, Lenz HJ: Mucinous adenocarcinomas with intra-abdominal dissemination: a review of current therapy. Oncologist; 2010;15(8):836-44
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  • Surgery removes the primary cancer and any dissemination within the peritoneal cavity and adjuvant HIPEC eradicates macroscopic or microscopic tumor residue, thus reducing the risk for recurrence.
  • The present review provides an update of the most recent data on the current therapy for pseudomyxoma peritonei (PMP) and mucinous colorectal adenocarcinoma (MCA) with metastatic disease confined to the peritoneum.
  • [MeSH-major] Adenocarcinoma, Mucinous / therapy. Peritoneal Neoplasms / therapy. Pseudomyxoma Peritonei / therapy

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  • (PMID = 20656916.001).
  • [ISSN] 1549-490X
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3228029
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44. Piana S, Asioli S, Foroni M: Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features. Virchows Arch; 2006 Feb;448(2):228-31
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  • [Title] Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features.
  • Rectal adenocarcinoma with diffuse oncocytic features is a very rare lesion, having been reported only once in the English literature.
  • We describe a case of oncocytic adenocarcinoma of the rectum, associated with a villous adenoma, arising on a 66-year-old man.
  • On histological examination, the adenocarcinoma was composed of neoplastic glands lined by a strongly eosinophilic, granular epithelium that deeply infiltrated the rectal wall.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16450120.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CDX2 Transcription Factor; 0 / CDX2 protein, human; 0 / Carcinoembryonic Antigen; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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45. Hattori H: Mucosal prolapse polyp arising on the anastomotic site or postpolypectomy site of the rectum endoscopically mimicking recurrence of adenocarcinoma. Dig Dis Sci; 2005 Aug;50(8):1548-9
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  • [Title] Mucosal prolapse polyp arising on the anastomotic site or postpolypectomy site of the rectum endoscopically mimicking recurrence of adenocarcinoma.
  • [MeSH-major] Polyps / etiology. Postoperative Complications. Rectal Prolapse / etiology. Rectum / surgery
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Anastomosis, Surgical / adverse effects. Diagnosis, Differential. Humans. Male. Proctoscopy. Rectal Neoplasms / pathology

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  • (PMID = 16110852.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Reipert BM, Tanneberger S, Pannetta A, Bedosti M, Poell M, Zimmermann K, Stellamor MT: Increase in autoantibodies against Fas (CD95) during carcinogenesis in the human colon: a hope for the immunoprevention of cancer? Cancer Immunol Immunother; 2005 Oct;54(10):1038-42
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  • [Title] Increase in autoantibodies against Fas (CD95) during carcinogenesis in the human colon: a hope for the immunoprevention of cancer?
  • A thorough understanding of the naturally occurring events in the immune system in response to carcinogenesis will facilitate the development of strategies for the immunoprevention of cancer.
  • The adenoma-carcinoma sequence in the human colon is a well-established clinical example of multi-step carcinogenesis and can be used for immunological studies.
  • Based on previous observations that both apoptosis and the expression of Fas (Apo-1, CD95) are altered during carcinogenesis in the human colon, we asked the question whether serum titers of autoantibodies against Fas show any modification during the adenoma-carcinoma sequence.
  • [MeSH-major] Adenocarcinoma / immunology. Adenoma / immunology. Antigens, CD95 / immunology. Autoantibodies / immunology. Colorectal Neoplasms / immunology
  • [MeSH-minor] Aged. Case-Control Studies. Colon / metabolism. Fas Ligand Protein. Female. Humans. Male. Membrane Glycoproteins / immunology. Membrane Glycoproteins / metabolism. Middle Aged. Rectum / metabolism. Up-Regulation

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  • (PMID = 15864586.001).
  • [ISSN] 0340-7004
  • [Journal-full-title] Cancer immunology, immunotherapy : CII
  • [ISO-abbreviation] Cancer Immunol. Immunother.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / Autoantibodies; 0 / FASLG protein, human; 0 / Fas Ligand Protein; 0 / Membrane Glycoproteins
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47. Vang R, Gown AM, Wu LS, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM: Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Mod Pathol; 2006 Nov;19(11):1421-8
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  • Immunohistochemical studies were performed to compare expression of CDX2 and cytokeratin 20, both markers of intestinal differentiation, in conjunction with coordinate expression of cytokeratin 7, in 90 mucinous tumors involving the ovary: 42 primary ovarian mucinous tumors (31 atypical proliferative (borderline) mucinous tumors (gastrointestinal type), 11 mucinous carcinomas) and 48 metastatic mucinous carcinomas of upper (pancreaticobiliary tract: 14; stomach: five) and lower (colon and rectum: 25; appendix: four) gastrointestinal tract origin.
  • [MeSH-major] Adenocarcinoma, Mucinous / chemistry. Biomarkers, Tumor / analysis. Gastrointestinal Neoplasms / chemistry. Homeodomain Proteins / analysis. Keratin-7 / analysis. Ovarian Neoplasms / chemistry
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-20 / analysis

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  • (PMID = 16980943.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7
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48. Misawa R, Kobayashi M, Ito M, Kato M, Uchikawa Y, Takagi S: Primary colonic signet ring cell carcinoma presenting carcinocythemia: an autopsy case. Case Rep Gastroenterol; 2008;2(3):301-7
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  • [Title] Primary colonic signet ring cell carcinoma presenting carcinocythemia: an autopsy case.
  • Primary colorectal signet ring cell carcinoma (SRCC) is a rare but distinctive type of mucin-producing adenocarcinoma of the large intestine with still controversial clinicopathological features and prognosis.
  • Carcinocythemia, the presence of circulating cancer cells in peripheral blood, is considered to be a rare but an ominous phenomenon occurring in the advanced stage of certain types of cancers, particularly mammary lobular carcinoma.
  • It can be assumed that carcinoma cells lacking intercellular cohesiveness and polarized cell membrane organization, including SRCs as well as lobular carcinoma cells, can readily get access to the peripheral circulation; however, to our knowledge, this is the first report of primary colorectal SRCC that presented carcinocythemia.

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  • [Cites] J Clin Pathol. 1986 May;39(5):514-23 [2424934.001]
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  • (PMID = 21490860.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3075188
  • [Keywords] NOTNLM ; Carcinocythemia / Colon / Disseminated intravascular coagulation / Signet ring cell carcinoma
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49. Vuong T, Devic S, Moftah B, Evans M, Podgorsak EB: High-dose-rate endorectal brachytherapy in the treatment of locally advanced rectal carcinoma: technical aspects. Brachytherapy; 2005;4(3):230-5
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  • [Title] High-dose-rate endorectal brachytherapy in the treatment of locally advanced rectal carcinoma: technical aspects.
  • PURPOSE: In this era of new radiation technologies and tumor imaging, a high-dose-rate endorectal brachytherapy has been developed and tested in a phase I/II study of advanced rectal tumors.
  • Patients with resectable rectal cancer (staged T2, T3, or early T4) were treated with preoperative high-dose-rate endorectal brachytherapy followed by surgery 6-8 weeks later.
  • The use of a multichannel flexible endorectal applicator leads to tumor downstaging before surgery in patients with resectable locally advanced rectal carcinomas.
  • [MeSH-major] Brachytherapy / instrumentation. Brachytherapy / methods. Radiotherapy Planning, Computer-Assisted / methods. Rectal Neoplasms / radiography. Rectal Neoplasms / radiotherapy

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  • (PMID = 16182224.001).
  • [ISSN] 1538-4721
  • [Journal-full-title] Brachytherapy
  • [ISO-abbreviation] Brachytherapy
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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50. Hermanek P, Junginger T: The circumferential resection margin in rectal carcinoma surgery. Tech Coloproctol; 2005 Dec;9(3):193-9; discussion 199-200
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  • [Title] The circumferential resection margin in rectal carcinoma surgery.
  • After radical resection of rectal carcinoma, the circumferential resection margin (CRM) on the non-peritonealized surface of the resected specimen is of critical importance.
  • [MeSH-major] Colectomy / methods. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / pathology. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Colonoscopy / methods. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neoadjuvant Therapy / methods. Neoplasm Staging. Predictive Value of Tests. Preoperative Care. Prognosis. Risk Assessment. Sensitivity and Specificity. Survival Analysis. Treatment Outcome

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  • (PMID = 16328130.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 14
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51. Koukourakis MI, Simopoulos C, Pitiakoudis M, Lyratzopoulos N, Romanidis K, Giatromanolaki A, Polychronidis A, Kouklakis G, Sivridis E, Minopoulos G, Manolas K: Hypofractionated accelerated radiotherapy, cytoprotection and capecitabine in the treatment of rectal cancer: a feasibility study. Anticancer Res; 2008 Sep-Oct;28(5B):3035-40
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  • [Title] Hypofractionated accelerated radiotherapy, cytoprotection and capecitabine in the treatment of rectal cancer: a feasibility study.
  • BACKGROUND: This is a report on the feasibility and efficacy of hypofractionated accelerated radiotherapy combined with amifostine cytoprotection (hypoARC) and capecitabine in the treatment of rectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / therapy. Amifostine / therapeutic use. Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Fluorouracil / analogs & derivatives. Radiation-Protective Agents / therapeutic use. Rectal Neoplasms / therapy

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  • (PMID = 19031952.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Radiation-Protective Agents; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; M487QF2F4V / Amifostine; U3P01618RT / Fluorouracil
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52. Wang LW, Yang SH, Lin JK, Lin TC, Chan WK, Chen WS, Wang HS, Jiang JK, Lee RC, Li AF, Chao Y, Chi KH, Yen SH: Pre-operative chemoradiotherapy with oral tegafur-uracil and leucovorin for rectal cancer. J Surg Oncol; 2005 Mar 15;89(4):256-63; discussion 263-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pre-operative chemoradiotherapy with oral tegafur-uracil and leucovorin for rectal cancer.
  • BACKGROUND: To evaluate the efficacy and toxicity of pre-operative radiotherapy (RT) combined with oral tegafur-uracil (UFUR) plus leucovorin (LV) in rectal cancer.
  • PATIENTS: Sixty-five patients with rectal adenocarcinoma (clinical staged T2-4N0-2M0) received pelvic RT of 45 Gy in 20 fractions over 28 days.
  • CONCLUSIONS: Oral UFUR + LV administered with pre-operative RT are effective in tumor DS, pathological complete response, and sphincter preservation with tolerable toxicity in rectal cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Rectal Neoplasms / drug therapy

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  • [CommentIn] J Surg Oncol. 2005 May 1;90(2):106-7 [15844186.001]
  • [ErratumIn] J Surg Oncol. 2005 May 1;90(2):106
  • (PMID = 15726610.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / UFT(R) drug; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q573I9DVLP / Leucovorin
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53. Theodosopoulos TK, Marinis AD, Dafnios NA, Vassiliou JG, Samanides LD, Carvounis EE, Smyrniotis VE: Aggressive treatment of metastatic squamous cell carcinoma of the rectum to the liver: a case report and a brief review of the literature. World J Surg Oncol; 2006;4:49
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  • [Title] Aggressive treatment of metastatic squamous cell carcinoma of the rectum to the liver: a case report and a brief review of the literature.
  • BACKGROUND: Rectal squamous cell carcinoma (SCC) is a rare tumor.
  • From a review of the English literature 55 cases of SCC of the rectum have been published.
  • In this study we report a rectal metastatic SCC to the liver, discussing the efficacy of aggressive adjuvant and neo-adjuvant therapies on survival and prognosis.
  • CASE PRESENTATION: A 39-year-old female patient with a pure SCC of the rectum diagnosed endoscopically is presented.
  • CONCLUSION: Although prognosis of rectal SCC is worse than that of adenocarcinoma, an aggressive therapeutic approach with surgery as the primary treatment, followed by combined neo- and adjuvant chemo-radiotherapy, may be necessary in order to improve survival and prognosis.

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  • (PMID = 16895595.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1555584
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54. Murata A, Inoue T, Maeda K, Noda E, Nagahara H, Kubo N, Tanaka H, Muguruma K, Yamada N, Ohira M, Hirakawa K: [A case report of advanced rectal cancer showing a pathological complete response by neo-adjuvant FOLFOX chemotherapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2623-5
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  • [Title] [A case report of advanced rectal cancer showing a pathological complete response by neo-adjuvant FOLFOX chemotherapy].
  • Colonoscopy detected an advanced rectal cancer.
  • Abdominoperineal resection of rectum was done, and a final pathological examination revealed a complete response of the main tumor.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Rectal Neoplasms / drug therapy

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  • (PMID = 21224659.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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55. Watanabe M, Tsuchiya M, Takita W, Otsuka Y, Tamura A, Yamazaki K, Koshino H, Kurihara A, Kaneko H, Teramoto T: [Case report of a liver metastasis from rectal cancer achieving complete response (CR) by a combination of intra-hepatic arterial infusion of irinotecan (CPT-11) with degradable starch microspheres (DSM) and weekly high-dose intra-hepatic arterial chemotherapy with 5-FU]. Gan To Kagaku Ryoho; 2006 Oct;33(10):1485-8
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  • [Title] [Case report of a liver metastasis from rectal cancer achieving complete response (CR) by a combination of intra-hepatic arterial infusion of irinotecan (CPT-11) with degradable starch microspheres (DSM) and weekly high-dose intra-hepatic arterial chemotherapy with 5-FU].
  • A 67-year-old woman, who was diagnosed with rectal cancer and liver metastasis, underwent a low anterior resection of the rectum in May 2004.
  • This case suggests that the use of intra-hepatic arterial infusion of CPT-11 and MMC with DSM is useful for the treatment of liver metastases in colorectal cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Rectal Neoplasms / drug therapy

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  • (PMID = 17033243.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / degradable starch microspheres; 50SG953SK6 / Mitomycin; 7673326042 / irinotecan; 9005-25-8 / Starch; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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56. Baeten CI, Hillen F, Pauwels P, de Bruine AP, Baeten CG: Prognostic role of vasculogenic mimicry in colorectal cancer. Dis Colon Rectum; 2009 Dec;52(12):2028-35
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  • [Title] Prognostic role of vasculogenic mimicry in colorectal cancer.
  • We investigated angiogenesis and the presence of vasculogenic mimicry in colorectal carcinoma in relation to tumor stage, patient survival, and genetic indicators of tumor cell plasticity.
  • METHODS: Paraffin-embedded tissue samples were examined from a study of 117 patients with colorectal carcinoma with a 12-year follow-up.
  • Cell cultures from 7 colon cell lines, real-time polymerase chain reaction (PCR) on cell lines, frozen tissue material from 4 colorectal cancer patients with and 4 without vasculogenic mimicry, and fresh colorectal cancer tissue from 2 patients were used to investigate the relationship between vasculogenic mimicry and tumor cell plasticity.
  • Cell culture experiments and real-time PCR on human colorectal carcinoma material showed evidence for vasculogenic mimicry with overexpression of EPHA2 and LAMC2, known to be important for the tube-forming capacity of melanoma tumor cells.
  • The presence of vasculogenic mimicry was associated with significantly shortened survival, both overall (P < 0.0001) and within intermediate cancer stages (Dukes B, P = 0.0277; Dukes C, P < 0.0001).
  • CONCLUSIONS: Vasculogenic mimicry can occur in colorectal carcinoma and appears to be comparable to vasculogenic mimicry described in other tumors.
  • Moreover, vasculogenic mimicry in colorectal carcinoma may be a strong independent prognostic marker for survival.
  • [MeSH-major] Adenocarcinoma / blood supply. Adenocarcinoma / pathology. Colorectal Neoplasms / blood supply. Colorectal Neoplasms / pathology. Neovascularization, Pathologic / diagnosis

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  • (PMID = 19934926.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / LAMC2 protein, human; 0 / Laminin; EC 2.7.10.1 / Receptor, EphA2
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57. Richetti A, Fogliata A, Clivio A, Nicolini G, Pesce G, Salati E, Vanetti E, Cozzi L: Neo-adjuvant chemo-radiation of rectal cancer with volumetric modulated arc therapy: summary of technical and dosimetric features and early clinical experience. Radiat Oncol; 2010;5:14
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  • [Title] Neo-adjuvant chemo-radiation of rectal cancer with volumetric modulated arc therapy: summary of technical and dosimetric features and early clinical experience.
  • BACKGROUND: To report about initial technical and clinical experience in preoperative radiation treatment of rectal cancer with volumetric modulated arcs with the RapidArc (RA) technology.
  • All showed locally advanced rectal adenocarcinoma with stage T2-T4, N0-1.
  • CONCLUSION: RA proved to be a safe, qualitatively advantageous treatment modality for rectal cancer, showing some improved results in dosimetric aspects.
  • [MeSH-major] Carcinoma / radiotherapy. Neoadjuvant Therapy / methods. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Intensity-Modulated / methods. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Capecitabine. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Female. Fluorouracil / analogs & derivatives. Fluorouracil / therapeutic use. Humans. Male. Middle Aged. Neoplasm Staging. Radiometry

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  • (PMID = 20170490.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2838920
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58. Kovacević D, Sonicki Z, Kusić Z, Bolanca A, Grubisić G, Lukac M, Lukac J: Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer. Int J Colorectal Dis; 2007 Jul;22(7):827-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer.
  • BACKGROUND AND AIM: Soluble c-erbB-2 oncoprotein has been proven as a useful marker in the management of breast cancer patients, but its value in diagnostics and follow-up of colorectal cancer patients remains controversial.
  • The aim of this study was to evaluate the usefulness of serum c-erbB-2 monitoring in diagnostics and prediction of disease outcome in rectal cancer patients.
  • MATERIALS AND METHODS: Serum samples from 88 patients with rectal adenocarcinoma before surgery and from 41 healthy controls were tested for the presence of c-erbB-2 oncoprotein by ELISA, and the patients were followed up for at least 5 years after the surgery.
  • Elevated preoperative serum c-erbB-2 levels showed relatively high specificity (88%) and low sensitivity (44%) in the diagnosis of rectal cancer.
  • CONCLUSION: Although preoperative serum c-erbB-2 levels were significantly higher in rectal cancer patients than in healthy controls, the soluble c-erbB-2 does not seem to be useful in the diagnosis of rectal cancer due to its low sensitivity.
  • Preoperative serum levels of this oncoprotein were predictive neither for overall survival nor for local recurrence/distant metastases in rectal cancer patients.
  • [MeSH-major] Adenocarcinoma / blood. Biomarkers, Tumor / blood. Colectomy. Receptor, ErbB-2 / blood. Rectal Neoplasms / blood

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  • (PMID = 17119985.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; EC 2.7.10.1 / Receptor, ErbB-2
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59. Cabassa P, Morone M, Gatti E, Narbone M, Maroldi R: Gardner syndrome complicated with hydronephrosis. A case report. J Radiol Case Rep; 2010;4(3):19-23
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  • We present a case of a man who was admitted for a relapse of adenocarcinoma of the rectum.
  • CT-staging showed multiple locations of desmoid tumors and osteomas, with final diagnosis of Gardner syndrome.

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  • (PMID = 22470715.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303379
  • [Keywords] NOTNLM ; Gardner / computed tomography / desmoid tumors
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60. Gupta NP, Ansari MS, Dass SC: Transrectal ultrasound guided biopsy for detecting early prostate cancer: An Indian experience. Indian J Cancer; 2005 Jul-Sep;42(3):151-4
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  • [Title] Transrectal ultrasound guided biopsy for detecting early prostate cancer: An Indian experience.
  • The sextant biopsy technique has been conventionally used for the diagnosis of prostate cancer.
  • We conducted a prospective study to determine whether the 5-region prostate biopsy technique significantly increases the chance of prostate cancer detection as compared to the sextant biopsy technique.
  • AIMS: To evaluate the efficacy of TRUS guided sextant and 5-region biopsy techniques in detecting carcinoma prostate in patients with PSA between 4 and 10 ng/ml and normal digital rectal examination.
  • METHODS AND MATERIAL: Between December 2001 and August 2003 one forty-two men, aged 49-82 years, who presented with LUTS, normal digital rectal examination (DRE) and PSA between 4 and 10 ng/ml underwent TRUS guided sextant prostate biopsy.
  • Serum PSA was reassessed after 3 months in patients whose biopsies were negative for cancer.
  • TRUS guided sextant biopsy revealed adenocarcinoma prostate in 34 men (24%).
  • Five (10.4%) patients were detected to have adenocarcinoma on repeat biopsy.
  • [MeSH-minor] Aged. Aged, 80 and over. Humans. India. Male. Middle Aged. Prospective Studies. Prostatic Hyperplasia / pathology. Prostatic Hyperplasia / ultrasonography. Rectum / ultrasonography. Time Factors


61. Sanchez LD, Chelliah T, Meisher I, Niranjan S: Rare case of breast tumor secondary to rectal adenocarcinoma. South Med J; 2008 Oct;101(10):1062-4
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  • [Title] Rare case of breast tumor secondary to rectal adenocarcinoma.
  • Primary breast cancer is the most common malignancy in women.
  • Metastatic cancer to the breast is very rare.
  • Colorectal cancers usually metastasize to the liver and the lung; other sites of metastasis from colon cancer are uncommon and are usually found in association with extensive liver and/or lung metastases.
  • This is a report of a rare case of aggressive rectal cancer with metastasis to the breast without liver or lung metastases.
  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / secondary. Rectal Neoplasms / pathology

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  • (PMID = 18791504.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Sakata J, Wakai T, Shirai Y, Sakata E, Hasegawa G, Hatakeyama K: Humoral hypercalcemia complicating adenocarcinoma of the sigmoid colon: report of a case. Surg Today; 2005;35(8):692-5
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  • [Title] Humoral hypercalcemia complicating adenocarcinoma of the sigmoid colon: report of a case.
  • Humoral hypercalcemia can arise from a variety of malignancies, but its association with primary colorectal carcinoma is rare, with only 20 such cases documented in the English-language literature to date.
  • We report an additional case to clarify the clinicopathologic features of colorectal carcinoma with humoral hypercalcemia.
  • A 54-year-old woman was admitted with symptomatic hypercalcemia of 14.2 mg/dl and multiple hepatic metastases, 2 years after resection of sigmoid colon cancer.
  • The hypercalcemia was caused by the circulating parathyroid hormone-related peptide (PTHrP) produced by poorly differentiated adenocarcinoma in the liver.
  • A review of the 21 reported cases, including ours, suggests that colorectal carcinoma associated with humoral hypercalcemia is characterized by a poorly differentiated tumor with or without squamous or neuroendocrine features, distant metastases, and a dismal prognosis.
  • [MeSH-major] Adenocarcinoma / complications. Hypercalcemia / etiology. Sigmoid Neoplasms / complications

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  • (PMID = 16034553.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein
  • [Number-of-references] 19
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63. Derin D, Eralp Y, Guney N, Ozlük Y, Topuz E: Ovarian carcinoma with simultaneous breast and rectum metastases. Onkologie; 2008 Apr;31(4):200-2
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  • [Title] Ovarian carcinoma with simultaneous breast and rectum metastases.
  • BACKGROUND: Metastatic involvement of the breast and the rectum from ovarian carcinoma are very rare events.
  • CASE REPORT: We report a case of ovarian carcinoma with metastasis to the breast and rectum simultaneously, 6 years after initial diagnosis.
  • RESULTS: Morphologic and immunohistochemical findings from pathologic samples of all involved sites confirmed the ovarian origin, which spared the patient unnecessary breast and rectal surgery.
  • To our knowledge, this is the first case of ovarian carcinoma with simultaneous metastases to the breast and rectum reported to date.
  • CONCLUSION: Accurate differential diagnosis from primary breast and rectal carcinoma is very important because the prognosis and treatment differ significantly.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / secondary. Cystadenocarcinoma, Papillary / pathology. Cystadenocarcinoma, Papillary / secondary. Ovarian Neoplasms / pathology. Rectal Neoplasms / pathology. Rectal Neoplasms / secondary

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  • [Copyright] 2008 S. Karger AG, Basel.
  • (PMID = 18418023.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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64. Vaghefi H, Magi-Galluzzi C, Klein EA: Local recurrence of prostate cancer in rectal submucosa after transrectal needle biopsy and radical prostatectomy. Urology; 2005 Oct;66(4):881
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  • [Title] Local recurrence of prostate cancer in rectal submucosa after transrectal needle biopsy and radical prostatectomy.
  • A 69-year-old man with clinical Stage T1cN0M0 prostate cancer underwent radical prostatectomy, revealing negative surgical margins, focal capsular penetration, and negative lymph nodes and seminal vesicles.
  • Five years later, his prostate-specific antigen level had increased to 0.2 ng/mL, and digital rectal examination revealed a palpable submucosal mass in the rectum that was confirmed by colonoscopy and transrectal ultrasonography.
  • Excisional biopsy revealed prostatic adenocarcinoma similar in appearance and grade to the initial needle biopsy.
  • This case report illustrates an extremely rare needle tract adenocarcinoma implantation after needle biopsy of the prostate.
  • [MeSH-major] Adenocarcinoma / pathology. Neoplasm Seeding. Prostatic Neoplasms / pathology. Rectal Neoplasms / secondary


65. Rahman GA: Rectal cancer: pattern and outcome of management in University of Ilorin Teaching Hospital, Ilorin, Nigeria. Ann Afr Med; 2010 Jul-Sep;9(3):164-9
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  • [Title] Rectal cancer: pattern and outcome of management in University of Ilorin Teaching Hospital, Ilorin, Nigeria.
  • BACKGROUND: Cancer of the colon and rectum was considered to be rare in Africa three to four decades ago.
  • The aim of this study is to determine the incidence of rectal cancer, its pattern of presentation, diagnosis, treatment and outcome of treatment at the University of Ilorin Teaching Hospital (UITH), Ilorin, Nigeria.
  • METHODS: This is a prospective study of all the patients with rectal cancer seen at the UITH from January 1998 to December 2002.
  • RESULTS: Thirty-six patients with rectal cancer were seen during the period.
  • CONCLUSION: Rectal cancer is not rare in Africans.
  • Since most cases in this environment are accessible to digital rectal examination (DRE), the need for this procedure in patients with lower gastrointestinal symptoms cannot be overemphasized.
  • [MeSH-major] Adenocarcinoma / pathology. Rectal Neoplasms / pathology. Rectum / surgery
  • [MeSH-minor] Adult. Age Distribution. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Combined Modality Therapy. Female. Follow-Up Studies. Hospitals, Teaching. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Nigeria / epidemiology. Prospective Studies. Radiotherapy. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 20710108.001).
  • [ISSN] 0975-5764
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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66. Lupattelli M, Maranzano E, Bellavita R, Natalini G, Corgna E, Rossetti R, Trippa F, Mascioni F, Sidoni A, Anselmo P, Buzzi F, Brugia M, Latini P: Raltitrexed and radiotherapy as adjuvant treatment for stage II-III rectal cancer: a feasibility study. Tumori; 2005 Nov-Dec;91(6):498-504
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  • [Title] Raltitrexed and radiotherapy as adjuvant treatment for stage II-III rectal cancer: a feasibility study.
  • AIMS AND BACKGROUND: Adjuvant 5-FU chemotherapy plus radiotherapy represents the standard treatment for radically resected rectal cancer at high risk of relapse according to the NIH Consensus Conference.
  • The aim of this prospective multicenter phase II study was to evaluate the feasibility, gastrointestinal and hematological acute toxicity of raltitrexed in combination with radiotherapy in rectal cancer patients.
  • METHODS: From September 2000 to June 2004, 50 patients with radically resected stage II-III rectal adenocarcinoma were treated.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Antimetabolites, Antineoplastic / therapeutic use. Quinazolines / therapeutic use. Rectal Neoplasms / drug therapy. Rectal Neoplasms / radiotherapy. Thiophenes / therapeutic use. Thymidylate Synthase / antagonists & inhibitors
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Drug Administration Schedule. Enzyme Inhibitors / therapeutic use. Feasibility Studies. Female. Humans. Male. Middle Aged. Neoplasm Staging. Patient Compliance. Prospective Studies. Radiotherapy Dosage. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 16457149.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Enzyme Inhibitors; 0 / Quinazolines; 0 / Thiophenes; EC 2.1.1.45 / Thymidylate Synthase; FCB9EGG971 / raltitrexed
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67. Bondar' GV, Psaras GG, Bondarenko NV, Ladur AI, Vasil'ev SD: [Surgery for cancer of proximal regions of the rectum]. Klin Khir; 2010 May;(5):18-20
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  • [Title] [Surgery for cancer of proximal regions of the rectum].
  • The results of treatment of 1652 patients, operated for proximal cancer recti, were presented.

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  • (PMID = 20623973.001).
  • [ISSN] 0023-2130
  • [Journal-full-title] Klinichna khirurhiia
  • [ISO-abbreviation] Klin Khir
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Ukraine
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68. Olschwang S, Bonaïti-Pellié C, Feingold J, Frébourg T, Grandjouan S, Lasset C, Laurent-Puig P, Lecuru F, Millat B, Sobol H, Thomas G, Eisinger F: [Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer), hereditary predisposition to colorectal and endometrial adenocarcinomas]. Pathol Biol (Paris); 2006 May;54(4):215-29
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  • [Title] [Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer), hereditary predisposition to colorectal and endometrial adenocarcinomas].
  • [Transliterated title] Identification et prise en charge du syndrome HNPCC (hereditary non polyposis colon cancer). Prédisposition héréditaire aux cancers du côlon, du rectum et de l'utérus.
  • BACKGROUND: The HNPCC syndrome (hereditary nonpolyposis colon cancer) is an inherited condition defined by clinical and genealogical information, known as Amsterdam criteria.
  • The identification of germline MMR mutations has no major consequence on the cancer treatments, but influences markedly the long-term follow-up and the management of at-risk relatives.
  • Gene carriers will enter a follow-up program regarding their colorectal and endometrial cancer risks, but other organs being at low lifetime risk, no specific surveillance will be proposed.
  • [MeSH-major] Adenocarcinoma / genetics. Colonic Neoplasms / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Endometrial Neoplasms / genetics. Rectal Neoplasms / genetics


69. Braat AE, Oosterhuis JW, Moll FC, de Vries JE, Wiggers T: Sentinel node detection after preoperative short-course radiotherapy in rectal carcinoma is not reliable. Br J Surg; 2005 Dec;92(12):1533-8
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  • [Title] Sentinel node detection after preoperative short-course radiotherapy in rectal carcinoma is not reliable.
  • BACKGROUND: Sentinel node (SN) detection may be used in patients with colonic carcinoma.
  • However, its use in patients with rectal carcinoma may be unreliable.
  • To address this, SN detection was evaluated in patients with rectal carcinoma after short-course preoperative radiotherapy.
  • In addition, SN detection was performed in 57 patients with colonic carcinoma.
  • RESULTS: A SN was identified in 26 of 34 patients with rectal carcinoma.
  • By contrast, SN detection was possible in 56 of 57 patient with colonic carcinoma with a sensitivity of 90 per cent, and four patients were upstaged.
  • CONCLUSION: The SN procedure for rectal carcinoma is not reliable in combination with TME and preoperative short-course radiotherapy.
  • [MeSH-major] Colonic Neoplasms / pathology. Rectal Neoplasms / pathology

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  • [Copyright] Copyright (c) 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 16231281.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Rosaniline Dyes; 129-17-9 / patent blue violet
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70. Bebenek M, Wojnar A: Infralevator lymphatic drainage of low-rectal cancers: preliminary results. Ann Surg Oncol; 2009 Apr;16(4):887-92
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  • [Title] Infralevator lymphatic drainage of low-rectal cancers: preliminary results.
  • BACKGROUND: Some low-rectal cancers may spread into or recur in the inguinal lymph nodes despite optimal resection of the primary tumor.
  • Hence, we hypothesized that lymphatic drainage of low-rectal malignancies may be inhomogeneous and that an extramesorectal route may be involved in at least some cases.
  • The idea of our preliminary study was to analyze the potential lymphatic drainages in low-rectal cancer patients.
  • METHODS: The first stage of the experiment included two consecutive low-rectal adenocarcinoma patients (free from inguinal lymph node metastases), in whom the lymphatics of the primary tumor were traced with Patentbalu dye.
  • During the second stage the records of 206 consecutive low-rectal cancer patients were analyzed for presence of inguinal lymph node metastases.
  • RESULTS: An evaluation of specimens from two rectal cancer patients revealed extramesorectal lymphatic drainage of the primary tumor besides the mesorectal route.
  • They were all diagnosed with rectal adenocarcinoma, T3 or T4 tumors with G2 or G3 grade.
  • CONCLUSION: The demonstration of an alternative route of lymphatic drainage suggests that more radical surgical procedures are necessary for successful treatment of low-rectal cancers.
  • [MeSH-major] Adenocarcinoma / pathology. Rectal Neoplasms / pathology

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  • (PMID = 19165544.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents
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71. Machiels JP, Duck L, Honhon B, Coster B, Coche JC, Scalliet P, Humblet Y, Aydin S, Kerger J, Remouchamps V, Canon JL, Van Maele P, Gilbeau L, Laurent S, Kirkove C, Octave-Prignot M, Baurain JF, Kartheuser A, Sempoux C: Phase II study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: the RadiOxCape study. Ann Oncol; 2005 Dec;16(12):1898-905
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  • [Title] Phase II study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: the RadiOxCape study.
  • BACKGROUND: Preoperative radiotherapy has been shown to decrease the local recurrence rate of patients with locally advanced rectal cancer.
  • Capecitabine and oxaliplatin are both active anticancer agents in the treatment of patients with advanced colorectal cancer and have radiosensitizing properties.
  • PATIENTS AND METHODS: Forty patients with rectal cancer (T3-T4 and/or N+) received radiotherapy (1.8 Gy, 5 days a week over 5 weeks, total dose 45 Gy, 3D conformational technique) in combination with intravenous oxaliplatin 50 mg/m2 once weekly for 5 weeks and oral capecitabine 825 mg/m2 twice daily on each day of radiation.
  • CONCLUSIONS: Combination of preoperative radiotherapy with capecitabine and oxaliplatin is feasible for downstaging rectal cancer.

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  • [CommentIn] Ann Oncol. 2006 Jun;17(6):1029-30; author reply 1030-1 [16384877.001]
  • (PMID = 16219623.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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72. Lidder PG, Hosie KB: Rectal cancer: the role of radiotherapy. Dig Surg; 2005;22(1-2):41-8; discussion 49
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  • [Title] Rectal cancer: the role of radiotherapy.
  • Surgery is the definitive tool in the management of patients with rectal carcinoma.
  • This article examines the role of radiotherapy in the management of patients with rectal carcinoma and explores the controversies that exist in its application.
  • [MeSH-major] Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Humans. Neoadjuvant Therapy. Neoplasm Recurrence, Local. Palliative Care. Radiotherapy Dosage. Radiotherapy, Adjuvant

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  • (PMID = 15838170.001).
  • [ISSN] 0253-4886
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 45
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73. Grigoliia NG, Gachechiladze MG, Chichua LG, Chkheidze GR, Bolotashvili ShN: [Lynch syndrome (case report)]. Georgian Med News; 2009 Apr;(169):7-9
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  • The authors have analyzed the ethology, pathogenesis, treatment of Lynch Syndrome and described a case history of a 65-year-old woman with right breast cancer who was admitted into a hospital with intestines impassability and operation was performed.
  • Apart from this, after the inner organ examination metastasis on stomach and tumour in upper and middle rectum were found.
  • Histology and colonoscopy revealed the rectum adenocarcinoma (morphologic code 8140/3) with mild differentiation.
  • Examination revealed adenocarcinoma with high and middle area differentiation (morphologic code 8480/3).
  • [MeSH-major] Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis. Colorectal Neoplasms, Hereditary Nonpolyposis / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Adenocarcinoma / therapy. Aged. Female. Humans. Rectal Neoplasms / diagnosis. Rectal Neoplasms / secondary. Rectal Neoplasms / surgery. Stomach Neoplasms / diagnosis. Stomach Neoplasms / secondary. Stomach Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19430032.001).
  • [ISSN] 1512-0112
  • [Journal-full-title] Georgian medical news
  • [ISO-abbreviation] Georgian Med News
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Georgia (Republic)
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74. Jang NY, Han TJ, Kang SB, Kim DW, Kim IA, Kim JS: The short-term effect of neoadjuvant chemoradiation on anorectal function in low and midrectal cancer: analysis using preoperative manometric data. Dis Colon Rectum; 2010 Apr;53(4):445-9
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  • [Title] The short-term effect of neoadjuvant chemoradiation on anorectal function in low and midrectal cancer: analysis using preoperative manometric data.
  • Patients were divided into 2 groups according to the tumor location; lower rectum (n = 52) and mid rectum (n = 28).
  • The paired t test was used to compare prechemoradiation and postchemoradiation parameters including the mean resting pressure, maximum squeeze pressure, percentage asymmetry of the resting and squeeze sphincter, length of the high-pressure zone, rectal sensory threshold, and rectal compliance.
  • RESULTS: In patients with a lower rectal cancer, there were significant differences in the percentage asymmetry of the squeeze sphincter (27.81 +/- 6.46 vs 25.38 +/- 5.93%, P < .01), length of the high-pressure zone (2.14 +/- 0.74 vs 2.33 +/- 0.72 cm, P = .05), and rectal compliance (1.14 +/- 0.41 vs 1.02 +/- 0.40 mL/mmHg, P = .04).
  • In patients with midrectal cancer, only the mean resting pressure increased significantly (45.08 +/- 18.57 vs 52.83 +/- 17.87 mmHg, P < .01).
  • Although there was a decrease in rectal compliance, it seemed that the tumor-downsizing effect compensated the expected worsening of anorectal function in the early postchemoradiation period.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / physiopathology. Adenocarcinoma / radiotherapy. Rectal Neoplasms / drug therapy. Rectal Neoplasms / physiopathology. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chi-Square Distribution. Female. Humans. Male. Manometry. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 20305445.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Khaniya S, Koirala R, Shakya VC, Adhikary S, Regmi R, Pandey SR, Agrawal CS: Anorectal tuberculosis coexisting with adenocarcinoma: an unusual association. Cases J; 2009;2:143
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  • [Title] Anorectal tuberculosis coexisting with adenocarcinoma: an unusual association.
  • On examination, she had nodular stricture in the lower rectum, with friable mucosa, bleeding easily on touch.
  • With the diagnosis of carcinoma lower rectum, she underwent abdomino-perineal resection of the growth.
  • The histopathological examination revealed carcinoma rectum with coexisting tuberculosis.
  • CONCLUSION: The aetiological association between the tuberculosis and anorectal cancer is a matter of debate.

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  • (PMID = 19292907.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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76. Fernandes LC, Kim SB, Saad SS, Matos D: Value of carcinoembryonic antigen and cytokeratins for the detection of recurrent disease following curative resection of colorectal cancer. World J Gastroenterol; 2006 Jun 28;12(24):3891-4
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  • [Title] Value of carcinoembryonic antigen and cytokeratins for the detection of recurrent disease following curative resection of colorectal cancer.
  • AIM: To evaluate the efficacy of postoperative serial assay of carcinoembryonic antigen (CEA) and cytokeratins for the detection of recurrent disease in patients with colorectal adenocarcinoma after radical surgery.
  • METHODS: Between 1993 and 2000, 120 patients with colorectal adenocarcinoma underwent radical surgery in the Department of Surgical Gastroenterology, Federal University of Sao Paulo-Escola Paulista de Medicina, Sao Paulo, Brazil.
  • CONCLUSION: Intensive follow-up by serial assay of CEA and cytokeratins allows early detection of colorectal neoplasm recurrence.
  • [MeSH-major] Adenocarcinoma / blood. Carcinoembryonic Antigen / blood. Colorectal Neoplasms / blood. Keratins / blood. Neoplasm Recurrence, Local / blood. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 16804977.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC4087940
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77. Yamamoto S, Fujita S, Akasu T, Moriya Y: Safety of laparoscopic intracorporeal rectal transection with double-stapling technique anastomosis. Surg Laparosc Endosc Percutan Tech; 2005 Apr;15(2):70-4
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  • [Title] Safety of laparoscopic intracorporeal rectal transection with double-stapling technique anastomosis.
  • To assess the feasibility and analyze the short-term outcomes of laparoscopic intracorporeal rectal transection with double-stapling technique anastomosis, a review was performed of a prospective registry of 67 patients who underwent laparoscopic sigmoidectomy and anterior resection with intracorporeal rectal transection and double-stapling technique anastomosis between July 2001 and January 2004.
  • Patients were divided into 3 groups: sigmoid colon/rectosigmoid carcinoma, upper rectal carcinoma, and middle/lower rectal carcinoma.
  • The number of cartridges required in bowel transection was significantly increased in patients with middle/lower rectal carcinoma, and significant differences were observed in the length of the first stapler cartridge fired for rectal transection.
  • Furthermore, mean operative time and blood loss were also significantly greater in the middle/lower rectum group; however, complication rates and postoperative course were similar among the 3 groups.
  • Laparoscopic intracorporeal rectal transection with double-stapling technique anastomosis can be performed safely without increased morbidity or mortality.
  • [MeSH-major] Anastomosis, Surgical / methods. Carcinoma / surgery. Colorectal Neoplasms / surgery. Laparoscopy / adverse effects. Rectum / surgery. Surgical Stapling / methods

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  • (PMID = 15821617.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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78. Lotter O, Amr A, Safi F: Prognostic significance of p53-expression in colorectal carcinoma as measured by a luminometric immunoassay. Ger Med Sci; 2010;8:Doc24
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  • [Title] Prognostic significance of p53-expression in colorectal carcinoma as measured by a luminometric immunoassay.
  • In the following study we examined if elevated levels of p53 correlate with worse prognosis in colorectal cancer.
  • METHODS: We have quantified the protein, using an immunoluminometric assay, in 144 cytosols of primary sporadic colorectal cancer tissues and in 96 specimen of normal mucosa.
  • CONCLUSION: Our investigation revealed that p53-overexpression as measured by a luminometric immunoassay, is not a useful predictor of prognosis in patients with colorectal adenocarcinoma.

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  • (PMID = 21063465.001).
  • [ISSN] 1612-3174
  • [Journal-full-title] German medical science : GMS e-journal
  • [ISO-abbreviation] Ger Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Luminescent Proteins; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC2975257
  • [Keywords] NOTNLM ; colorectal cancer / p53-protein / prognosis / tumor markers
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79. Fujita S, Yamamoto S, Akasu T, Moriya Y: Outcome of patients with clinical stage II or III rectal cancer treated without adjuvant radiotherapy. Int J Colorectal Dis; 2008 Nov;23(11):1073-9
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  • [Title] Outcome of patients with clinical stage II or III rectal cancer treated without adjuvant radiotherapy.
  • BACKGROUND: To clarify the indications for preoperative adjuvant radiotherapy for rectal cancer, the outcome of patients who underwent curative surgery without adjuvant radiotherapy was investigated.
  • METHODS: A total of 817 consecutive patients who underwent curative surgery for clinical stage II or III rectal cancer without preoperative adjuvant radiotherapy between 1988 and 2002 were reviewed.
  • In patients with rectal cancer located less than 5 cm from the anal verge and with positive cN, the local recurrence rate was more than 10%.
  • CONCLUSIONS: Patients with rectal cancer located less than 5 cm from the anal verge and with clinically positive lymph nodes should be given preoperative adjuvant radiotherapy.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colectomy / methods. Disease Progression. Female. Follow-Up Studies. Humans. Incidence. Japan / epidemiology. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 18594841.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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80. Annam V, Panduranga C, Kodandaswamy C, Suresh DR: Primary mucinous adenocarcinoma in an ileostomy with adjacent skin invasion: a late complication of surgery for ulcerative colitis. J Gastrointest Cancer; 2008;39(1-4):138-40
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  • [Title] Primary mucinous adenocarcinoma in an ileostomy with adjacent skin invasion: a late complication of surgery for ulcerative colitis.
  • INTRODUCTION: Adenocarcinoma of the ileostomy after colectomy performed for non-neoplastic condition are relatively uncommon.
  • Mucinous adenocarcinoma at an ileostomy site represents a late complication of total colectomy performed for ulcerative colitis.
  • CASE REPORT: We here report a case of mucinous adenocarcinoma of the mucocutaneous junction at the ileostomy site with adjacent skin invasion occurring 35 years after total colectomy for ulcerative colitis.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Colitis, Ulcerative / surgery. Ileal Neoplasms / etiology. Ileostomy / adverse effects. Postoperative Complications / etiology. Skin / pathology
  • [MeSH-minor] Aged. Humans. Male. Neoplasm Invasiveness


81. Zhang W, Ho KS, Han HJ, Kong CS, Eu KW: Successful resuscitation after carbon dioxide embolism during laparoscopic-assisted abdomino-perineal resection. Singapore Med J; 2005 Jul;46(7):347-8
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  • We report a 67-year-old woman who underwent laparoscopic-assisted abdomino-perineal resection for rectal carcinoma.
  • [MeSH-minor] Aged. Carbon Dioxide. Female. Humans. Laparoscopy. Posture. Rectal Neoplasms / surgery

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  • (PMID = 15968448.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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82. Kelley ST, Coppola D, Yeatman T, Marcet J: Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways. Clin Colorectal Cancer; 2005 Jul;5(2):114-8
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  • [Title] Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways.
  • BACKGROUND: We tested the hypothesis that rectal tumors are most responsive to neoadjuvant therapy if they possess p53 and/or caspase 8 activity.
  • PATIENTS AND METHODS: Fifty patients diagnosed with biopsy-proven rectal cancer underwent neoadjuvant chemoradiation therapy consisting of 5-fluorouracil (300 mg/m(2) daily) and radiation (4,500 cGy).
  • Endorectal ultrasonography was performed before and after neoadjuvant therapy along with digital rectal examination and/or sigmoidoscopy for staging purposes and to evaluate response to therapy.
  • There were 10 stage I tumors (20%), 22 stage II tumors (44%), and 18 stage III tumors (36%) in the cohort at the time of initial diagnosis. p53 protein staining (ie, mutated p53) was positive in 31 tumors (62%; CR, n = 8; PR, n = 11; NR, n = 12); caspase 8 positivity was apparent in 30 specimens (60%; CR, n = 13; PR, n = 13; NR, n = 4).
  • [MeSH-major] Adenocarcinoma / therapy. Caspases / metabolism. Neoadjuvant Therapy. Rectal Neoplasms / therapy. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 16098252.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Biomarkers; 0 / Tumor Suppressor Protein p53; EC 3.4.22.- / CASP8 protein, human; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspases; U3P01618RT / Fluorouracil
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83. Bertelsen CA, Andreasen AH, Jørgensen T, Harling H, Danish Colorectal Cancer Group: Anastomotic leakage after curative anterior resection for rectal cancer: short and long-term outcome. Colorectal Dis; 2010 Jul;12(7 Online):e76-81
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  • [Title] Anastomotic leakage after curative anterior resection for rectal cancer: short and long-term outcome.
  • OBJECTIVE: The influence of symptomatic anastomotic leakage (AL) after anterior resection (AR) for rectal cancer on short and long-term mortality and local and distant recurrence was analysed.
  • METHOD: All patients with a first diagnosis of rectal carcinoma were prospectively registered in a national database.
  • CONCLUSION: Anastomotic leakage after AR for rectal cancer increases the 30-day and long-term mortality, but AL did not increase the risk of local and distant recurrence.
  • [MeSH-major] Colectomy / adverse effects. Rectal Neoplasms / surgery. Rectum / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anastomosis, Surgical / adverse effects. Anastomosis, Surgical / mortality. Denmark / epidemiology. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Postoperative Complications. Prognosis. Prospective Studies. Risk Factors. Survival Rate / trends. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 19438879.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Investigator] Gustafsen J; Wille-Jorgensen P; Bülow S; Wied U; Raskov HH; Crone P; Ronholt C; Hansen OH; Jess P; Kirkeby L; Iversen E; Haakansson T; Andersen OB; Nymark J; Lawaetz O; Rahr H; Madsen P; V Andersen P; Buch N; Teglaard P; Jensen KE; Berg V; Thomsen H; Klaerke M; Bisgaard C; Sloth H; Madsen MR; Madsen G; Christensen H; Nielsen JD; Mark M; Lausten-Thomsen HH; Nord S; Gandrup P; Lauesen N; Lundhus E; Malling N
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84. Pesce GA, Clivio A, Cozzi L, Nicolini G, Richetti A, Salati E, Valli M, Vanetti E, Fogliata A: Early clinical experience of radiotherapy of prostate cancer with volumetric modulated arc therapy. Radiat Oncol; 2010;5:54
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  • [Title] Early clinical experience of radiotherapy of prostate cancer with volumetric modulated arc therapy.
  • BACKGROUND: To report about initial clinical experience in radiation treatment of carcinoma of prostate with volumetric modulated arcs with the RapidArc (RA) technology.
  • METHODS: Forty-five patients with a median age of 72 +/- 3, affected by prostate carcinoma (T1c: 22 patients, T2a-b: 17 patients, T3a-b: 6 patients.
  • For rectum, all planning objectives were largely met (e.g.
  • Concerning acute toxicity, no patient showed grade 2-3 rectal toxicity; 5/42 (12%) patients experienced grade 2 dysuria; 18/41 (44%) patients preserved complete or partial erectile function.
  • CONCLUSION: RapidArc proved to be a safe, qualitative and advantageous treatment modality for prostate cancer.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Prostatic Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Feasibility Studies. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted


85. Chennupati SK, Kamaya A, Fisher GA, Ford JM, Kunz P, Itakura H, Welton ML, Shelton A, Van Dam J, Koong AC, Chang DT: Pathological response after chemoradiation for T3 rectal cancer. Colorectal Dis; 2010 Jul;12(7 Online):e24-30
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  • [Title] Pathological response after chemoradiation for T3 rectal cancer.
  • OBJECTIVE: The aim of this study was to investigate the effect of preoperative chemoradiotherapy (CRT) on nodal disease in locally advanced rectal adenocarcinoma.
  • METHOD: Thirty-two patients staged uT3N0 and 27 patients staged uT3N1 rectal adenocarcinoma who underwent pre-CRT staging using endoscopic ultrasound or rectal protocol CT were included.
  • [MeSH-major] Adenocarcinoma / diagnosis. Antineoplastic Agents / therapeutic use. Endosonography / methods. Neoplasm Staging. Rectal Neoplasms / diagnosis. Rectum / pathology

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  • (PMID = 19614668.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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86. Planelles Gómez J, Beltrán Armada JM, Alonso Hernández S, Tarín Planes M, Beamud Cortés M, Gil Salom M: [Value of transrectal FNA in the diagnosis of prostate cancer in elderly patients]. Actas Urol Esp; 2008 May;32(5):485-91
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  • [Title] [Value of transrectal FNA in the diagnosis of prostate cancer in elderly patients].
  • [Transliterated title] Valor de la PAAF transrectal en el diagnóstico del cáncer de próstata en pacientes de edad avanzada.
  • OBJECTIVES: To identify if there is a group elderly patients with clinical suspicion of prostate cancer in which pathological confirmation may be unnecessary, and if prostatic transrectal fine needle aspiration (FNA) may be a useful diagnostic tool for old patients.
  • RESULTS: In 35 patients (48.6%) cytological diagnosis was positive for prostatic adenocarcinoma, whereas in 37 cytology was negative for cancer.
  • In 100% of patients with PSA > 30 ng/ml or with PSA > 20 ng/ml and suspicious digital rectal examination FNA results were positive for cancer.
  • CONCLUSIONS: In male patients older than 75 years with PSA > 30 ng/ml or with PSA > 20 ng/ml and suspicious digital rectal examination, histological confirmation of carcinoma by prostatic biopsy may be not necessary, because of the high probability of a positive result.
  • When histological confirmation of prostatic carcinoma is required in elderly patients, transrectal prostatic FNA is a valid alternative to transrectal biopsy, due to its excellent tolerance and low complication rate.
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Biopsy, Fine-Needle / methods. Humans. Male. Prospective Studies. Rectum


87. Kume S, Kubota T, Takahashi M, Hashimoto D, Hirata T, Torigoe Y, Ikeda O: [A case of locally advanced rectal cancer responding to FOLFOX]. Gan To Kagaku Ryoho; 2009 Apr;36(4):659-61
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  • [Title] [A case of locally advanced rectal cancer responding to FOLFOX].
  • The 57-year-old man was underwent sigmoid colostomy due to unresectable rectal carcinoma.
  • Preoperative chemotherapy with FOLFOX appears a promising regimen for patients with unresectable rectal cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Rectal Neoplasms / drug therapy. Rectal Neoplasms / pathology
  • [MeSH-minor] Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Organoplatinum Compounds / therapeutic use. Proctoscopy

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  • (PMID = 19381043.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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88. Wu ZY, Wan J, Li JH, Zhao G, Peng L, Yao Y, Du JL, Liu QF, Wang ZD, Huang ZM, Lin HH: Study of circumferential resection margin in patients with middle and lower rectal carcinoma. World J Gastroenterol; 2007 Jun 28;13(24):3380-3
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  • [Title] Study of circumferential resection margin in patients with middle and lower rectal carcinoma.
  • AIM: To clarify the relationship between circumferential resection margin status and local and distant recurrence as well as survival of patients with middle and lower rectal carcinoma.
  • The relationship between circumferential resection margin status and clinicopathologic characteristics of middle and lower rectal carcinoma was also evaluated.
  • METHODS: Cancer specimens from 56 patients with middle and lower rectal carcinoma who received total mesorectal excision at the Department of General Surgery of Guangdong Provincial People's Hospital were studied.
  • RESULTS: Local recurrence occurred in 12.5% (7 of 56 cases) of patients with middle and lower rectal carcinoma.
  • Distant recurrence occurred in 25% (14 of 56 cases) of patients with middle and lower rectal carcinoma.
  • In 18 cancer specimens with tumor diameter >= 5 cm 7 (38.9%) were detected as positive circumferential resection margin, while in 38 cancer specimens with a tumor diameter of < 5 cm only 5 (13.2%) were positive for circumferential resection margin (P = 0.028).
  • The circumferential resection margin status is an important predictor of local and distant recurrence as well as survival of patients with middle and lower rectal carcinoma.
  • [MeSH-major] Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 17659680.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4172721
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89. Radonak J, Lakyová L, Toporcer T: [Uncommon rectal adenocarcinoma metastases]. Rozhl Chir; 2010 Aug;89(7):441-5
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  • [Title] [Uncommon rectal adenocarcinoma metastases].
  • [Transliterated title] Nezvycajné metastazovanie adenokarcinómu rekta.
  • Rectal cancer treatment has become multimodal as a result of significant advances in imaging diagnostic, in surgery technique of re section and in neo and adjuvant therapy.
  • The aim of the case report was to present a successfully treated adenocarcinoma recti and adenocarcinoma of hepatal flexurae with recidivistic metastasis and an extremely rare intergrowth of the metastasis into venous system.
  • A 61 year old patient underwent low resection of recti according to Dixon because of well differentiated adenocarcinoma with classification T3N0M0.
  • The patient was reoperated because of metastasis of adenocarcinoma in the abdominal wall (16 x 15 x 20 cm) after chemotherapy (FUL-5-fluorouracyl) and radiation dose of 50.4 Gy.
  • 26 months after the first operation, a new sessile polyp was found in the hepatal flexurae with histological finding of well differentiated adenocarcinoma.
  • [MeSH-major] Abdominal Neoplasms / secondary. Abdominal Wall. Adenocarcinoma / secondary. Rectal Neoplasms / pathology

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  • (PMID = 20925261.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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90. Zbar AP, Bernstein S, Greaves N, Iniss M, Shenoy RK: The utilization of intraluminal formalin for intractable rectal haemorrhage in advanced rectal cancer: a case report. Tech Coloproctol; 2005 Apr;9(1):49-51
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  • [Title] The utilization of intraluminal formalin for intractable rectal haemorrhage in advanced rectal cancer: a case report.
  • A patient with a metastatic fixed low rectal carcinoma presented severe rectal bleeding requiring massive transfusion over with a 36-hour period.
  • This technique has been reserved for intractable transfusion-dependent radiation proctitis and is presented as a primary alternative in severe rectal bleeding from inoperable rectal cancer.
  • [MeSH-major] Formaldehyde / therapeutic use. Gastrointestinal Hemorrhage / therapy. Rectal Neoplasms / complications
  • [MeSH-minor] Administration, Rectal. Adult. Female. Humans

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  • (PMID = 15868500.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 1HG84L3525 / Formaldehyde
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91. Soumarová R, Skrovina M, Machala S, Adamcík L, Bartos J: [Intraoperative radiotherapy in multimodality treatment of locally advanced rectal carcinoma]. Rozhl Chir; 2010 Nov;89(11):685-8
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  • [Title] [Intraoperative radiotherapy in multimodality treatment of locally advanced rectal carcinoma].
  • [Transliterated title] Intraoperacní radioterapie v multimodalitní lécbe lokálne pokrocilého karcinomu rekta.
  • Multimodality treatment of locally advanced rectal cancer combines radical surgery, radiotherapy and chemotherapy.
  • [MeSH-major] Rectal Neoplasms / radiotherapy

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  • (PMID = 21409803.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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92. Petrie N, Branagan G, McGuiness C, McGee S, Fuller C, Chave H: Reconstruction of the perineum following anorectal cancer excision. Int J Colorectal Dis; 2009 Jan;24(1):97-104
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  • [Title] Reconstruction of the perineum following anorectal cancer excision.
  • PURPOSE: Most patients with anal cancer receive chemoradiotherapy as first-line treatment.
  • A proportion of the 20,000 new cases of rectal carcinoma diagnosed in the UK each year receive neo-adjuvant chemoradiation and then an APR.
  • This study investigates a series of 18 patients who underwent APR for anorectal cancer with flap reconstruction of their perineum.
  • RESULTS: Between November 2000 and October 2007, 18 cases were performed (M/F = 7:11), six for anal cancer and 12 for low rectal tumours.
  • [MeSH-major] Perineum / surgery. Rectal Neoplasms / therapy. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma / therapy. Chemotherapy, Adjuvant. Cohort Studies. Female. Humans. Length of Stay. Male. Middle Aged. Neoadjuvant Therapy. Postoperative Complications. Radiotherapy, Adjuvant. Retrospective Studies. Wound Healing

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  • (PMID = 18688618.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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93. Mureşan M, Bancu S, Bara T, Bancu L, Turcu M, Mureşan S: [Local recurrence after the sphincter-saving operations and abdominal perineal resection in rectal cancer]. Chirurgia (Bucur); 2009 Jul-Aug;104(4):415-8
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  • [Title] [Local recurrence after the sphincter-saving operations and abdominal perineal resection in rectal cancer].
  • [Transliterated title] Recidiva tumorală locală după chirurgia conservatoare şi rezecţia abdominoperineală în cancerul rectal.
  • By local recurrence we define the appearance of the same anatomopathological type of cancer like the one initially described in the primary tumor, limited at the rectum or pelvis.The study is based on the analysis of all the cases with rectal cancer who undergone surgical procedures in Surgical Clinic No.2 Tg.
  • Using the most important parameters for each patient we identified some risk factors for the recurrence of the rectal cancer: surgical procedures--there were no major variations in the local recurrence between the sphincter-saving operations and abdominal perineal resections.
  • The recurrent rectal cancer is more frequent in aged patients with high aggressive adenocarcinomas.
  • [MeSH-major] Abdomen / surgery. Adenocarcinoma / surgery. Anal Canal. Neoplasm Recurrence, Local / surgery. Perineum / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / surgery. Aged. Carcinoma, Squamous Cell / surgery. Digestive System Surgical Procedures / methods. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 19886048.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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94. Choe KS, Jani AB, Liauw SL: External beam radiotherapy for prostate cancer patients on anticoagulation therapy: how significant is the bleeding toxicity? Int J Radiat Oncol Biol Phys; 2010 Mar 1;76(3):755-60
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  • [Title] External beam radiotherapy for prostate cancer patients on anticoagulation therapy: how significant is the bleeding toxicity?
  • PURPOSE: To characterize the bleeding toxicity associated with external beam radiotherapy for prostate cancer patients receiving anticoagulation (AC) therapy.
  • METHODS AND MATERIALS: The study cohort consisted of 568 patients with adenocarcinoma of the prostate who were treated with definitive external beam radiotherapy.
  • Dose-volume histogram analysis revealed that Grade 3 or worse bleeding was minimized if the percentage of the rectum receiving >or=70 Gy was <10% or the rectum receiving >or=50 Gy was <50%.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Anticoagulants / adverse effects. Hemorrhage / etiology. Prostatic Neoplasms / radiotherapy. Radiotherapy, Conformal / adverse effects
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Androgen Antagonists / therapeutic use. Follow-Up Studies. Humans. Male. Middle Aged. Multivariate Analysis. Radiotherapy Dosage. Radiotherapy, Intensity-Modulated / adverse effects. Rectum / radiation effects. Severity of Illness Index. Ticlopidine / adverse effects. Ticlopidine / analogs & derivatives. Transurethral Resection of Prostate / adverse effects. Urologic Diseases / etiology. Warfarin / adverse effects

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19464123.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgen Antagonists; 0 / Anticoagulants; 5Q7ZVV76EI / Warfarin; A74586SNO7 / clopidogrel; OM90ZUW7M1 / Ticlopidine
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95. Stelzmueller I, Zitt M, Aigner F, Kafka-Ritsch R, Jäger R, De Vries A, Lukas P, Eisterer W, Bonatti H, Ofner D: Postoperative morbidity following chemoradiation for locally advanced low rectal cancer. J Gastrointest Surg; 2009 Apr;13(4):657-67
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  • [Title] Postoperative morbidity following chemoradiation for locally advanced low rectal cancer.
  • BACKGROUND: Postoperative morbidity remains a significant clinical problem and may alter long-term outcome particularly after neoadjuvant chemoradiation in patients with locally advanced low rectal cancer.
  • METHODS: Analysis of prospectively collected data of 90 consecutive patients who underwent neoadjuvant chemoradiation and curative mesorectal excision for locally advanced (cT3/4, Nx, M0/1) adenocarcinoma of the mid and lower third of the rectum during a 7-year period (1996-2002).
  • CONCLUSION: Early postoperative morbidity in patients with preoperative chemoradiation due to locally advanced low rectal cancer is demonstrated as an independent prognosticator.
  • [MeSH-major] Adenocarcinoma / surgery. Postoperative Complications / epidemiology. Rectal Neoplasms / surgery

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  • (PMID = 19082672.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Sprenger T, Rothe H, Langer C, Becker H, Liersch T: Comment on "lymph nodes after preoperative chemoradiotherapy for rectal carcinoma: number, status, and impact on survival". Am J Surg Pathol; 2009 Jul;33(7):1107; author reply 1108
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comment on "lymph nodes after preoperative chemoradiotherapy for rectal carcinoma: number, status, and impact on survival".
  • [MeSH-major] Adenocarcinoma / pathology. Lymphatic Metastasis / pathology. Rectal Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Humans. Lymph Nodes / pathology. Neoadjuvant Therapy. Neoplasm Staging. Radiotherapy

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  • [CommentOn] Am J Surg Pathol. 2008 Jan;32(1):45-50 [18162769.001]
  • (PMID = 19390426.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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97. Mourra N, Zeitoun G, Buecher B, Finetti P, Lagarde A, Adelaide J, Birnbaum D, Thomas G, Olschwang S: High frequency of chromosome 14 deletion in early-onset colon cancer. Dis Colon Rectum; 2007 Nov;50(11):1881-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High frequency of chromosome 14 deletion in early-onset colon cancer.
  • PURPOSE: Several genes have been recognized, when mutated in the germline, to highly predispose to colorectal cancer, impairing the DNA mismatch repair system in hereditary nonpolyposis colon cancer syndrome, or APC/MYH in adenomatous polyposis.
  • However, 10 percent of microsatellite stable colorectal cancer is reported to develop in an unexplained context of genetic predisposition.
  • METHODS: Patients younger than aged 50 years undergoing primary surgical resection for colon carcinoma were collected prospectively between 1993 and 2003.
  • [MeSH-major] Adenocarcinoma / genetics. Chromosome Deletion. Chromosomes, Human, Pair 14 / genetics. Microsatellite Instability
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. DNA, Neoplasm / genetics. Female. Gene Expression Profiling. Genes, Tumor Suppressor. Genotype. Humans. Male. Middle Aged. Polymorphism, Single Nucleotide

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  • (PMID = 17726634.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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98. Kanczuga-Koda L, Sulkowski S, Koda M, Sulkowska M: Alterations in connexin26 expression during colorectal carcinogenesis. Oncology; 2005;68(2-3):217-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue samples (152 from colorectal cancer and 75 from adenoma) were investigated by immunohistochemistry, using the antibody for Cx26.
  • Moreover, Cx26 was assessed in normal epithelium of the colon and rectum, adjacent to colorectal cancer.
  • Among 152 colorectal cancers, 55.9% classified only as adenocarcinoma stained positive for Cx26, but mainly cytoplasmic staining was found.

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16015037.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Connexins; 127120-53-0 / connexin 26
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99. Sebag-Montefiore D, Stephens RJ, Steele R, Monson J, Grieve R, Khanna S, Quirke P, Couture J, de Metz C, Myint AS, Bessell E, Griffiths G, Thompson LC, Parmar M: Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet; 2009 Mar 07;373(9666):811-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial.
  • BACKGROUND: Preoperative or postoperative radiotherapy reduces the risk of local recurrence in patients with operable rectal cancer.
  • 1350 patients with operable adenocarcinoma of the rectum were randomly assigned, by a minimisation procedure, to short-course preoperative radiotherapy (25 Gy in five fractions; n=674) or to initial surgery with selective postoperative chemoradiotherapy (45 Gy in 25 fractions with concurrent 5-fluorouracil) restricted to patients with involvement of the circumferential resection margin (n=676).
  • INTERPRETATION: Taken with results from other randomised trials, our findings provide convincing and consistent evidence that short-course preoperative radiotherapy is an effective treatment for patients with operable rectal cancer.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Postoperative Care. Preoperative Care. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Quality of Life. Survival Analysis. United Kingdom


100. Ovrebo K, Rokke O: Extended lymph node dissection in colorectal cancer surgery. Reliability and reproducibility in assessments of operative reports. Int J Colorectal Dis; 2010 Feb;25(2):213-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extended lymph node dissection in colorectal cancer surgery. Reliability and reproducibility in assessments of operative reports.
  • For rectal resections, reproducibility was moderate (kappa: 0.45-0.58), and reliability was fair (kappa: 0.29-0.36; all kappa values: p < 0.001).
  • The 5-year survival rates of colonic cancer patients subject to a limited or extended procedure were 52% (45-60%, 95% confidence interval) and 69% (53-84%; p = 0.034), respectively.
  • In rectal cancer patients, the 5-year survival rates of a limited or extended procedure were 63% (54-72%) and 55% (37-73), respectively.
  • Extended lymph node dissection improves long-term survival rates of colonic cancer patients.
  • [MeSH-major] Adenocarcinoma / surgery. Colorectal Neoplasms / surgery. Digestive System Surgical Procedures. Lymph Node Excision
  • [MeSH-minor] Female. Humans. Kaplan-Meier Estimate. Lymphatic Metastasis. Male. Neoplasm Staging. Observer Variation. Proportional Hazards Models. Reproducibility of Results. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 19865821.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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