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[Title] [Combined radiotherapy and hormone therapy in non metastatic adenocarcinoma of prostate].

[Transliterated title] Hormonoradiothérapie des adénocarcinomes non métastatiques de la prostate.

Non metastatic adenocarcinoma of prostate can be cured in the vast majority of cases with surgery and/or external or interstitial radiotherapy.

Analysis of results of recent randomised trials comparing this association and exclusive radiotherapy allows for validating concept of combined radiotherapy and hormono therapy in locally advanced adenocarcinoma of prostate, while many questions should be more clearly answered.

[MeSH-major] Androgen Antagonists / therapeutic use. Prostatic Neoplasms / drug therapy. Prostatic Neoplasms / radiotherapy

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(PMID = 16396754.001).

[ISSN] 1769-6917

[Journal-full-title] Bulletin du cancer

[ISO-abbreviation] Bull Cancer

[Language] fre

[Publication-type] English Abstract; Journal Article

[Publication-country] France

[Chemical-registry-number] 0 / Androgen Antagonists; 0 / Antineoplastic Agents, Hormonal

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Multiple urinary bladder masses from metastatic prostate adenocarcinoma.

We present an unusual case of metastatic prostate adenocarcinoma that manifested with multiple exophytic intravesical masses, mimicking a multifocal primary bladder tumor.

Biopsy with immunohistochemical analysis confirmed metastatic prostate adenocarcinoma.

This case illustrates that when a patient with known prostate cancer presents with multifocal bladder tumors, the possibility of metastatic prostate cancer should be considered.

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[Cites] Histopathology. 2000 Jan;36(1):32-40 [10632749.001]

[Cites] Int J Radiat Oncol Biol Phys. 2000 May 1;47(2):379-88 [10802363.001]

[Cites] Hinyokika Kiyo. 2001 Oct;47(10):747-9 [11758360.001]

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[Cites] J Natl Cancer Inst. 2009 Sep 16;101(18):1280-3 [19713548.001]

[Cites] Hinyokika Kiyo. 2010 Feb;56(2):123-5 [20186001.001]

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[Cites] Lancet. 2009 Jan 24;373(9660):301-8 [19091394.001]

[Cites] Radiother Oncol. 2009 Nov;93(2):192-6 [19464745.001]

(PMID = 21234257.001).

[ISSN] 2036-3613

[Journal-full-title] Rare tumors

[ISO-abbreviation] Rare Tumors

[Language] eng

[Publication-type] Journal Article

[Publication-country] Italy

[Other-IDs] NLM/ PMC3019600

[Keywords] NOTNLM ; prostatic neoplasms / radiotherapy. / urinary bladder neoplasms

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Choroidal metastasis from clinically regressed prostate adenocarcinoma: imaging of a rare case].

[Transliterated title] Métastase choroïdienne d'un adénocarcinome de la prostate: iconographie d'un cas rare.

We report a rare case of prostatic adenocarcinoma metastases at the choroids, diagnosed and followed by fluorescein angiography (FA), indocyanine-green angiography (ICGA), and optical coherence tomography (OCT-3 Stratus).

The systemic workup, including hematologic analysis and total-body computed tomography (CT), revealed elevated serum prostate-specific antigen (PSA) and alkaline phosphatase, extensive abnormalities of the axial skeleton, and nodular pulmonary shadows; therefore, prostatic adenocarcinoma was suspected.

Needle biopsies (prostatic and pulmonary) confirmed adenocarcinoma of the prostate, with metastatic disease.

DISCUSSION: Prostatic carcinoma should be considered in any male patient with a choroidal mass suspected of being a metastasis.

In our patient, FA, ICGA, and OCT clearly documented the complete regression of choroidal metastasis from prostatic carcinoma.

Fluorescein angiography, indocyanine-green angiography, and optical coherence tomography are useful tools in the diagnosis and follow-up of prostatic adenocarcinoma metastatic to the choroid.

[MeSH-major] Adenocarcinoma / secondary. Choroid Neoplasms / secondary. Prostatic Neoplasms / pathology

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(PMID = 19107059.001).

[ISSN] 1773-0597

[Journal-full-title] Journal français d'ophtalmologie

[ISO-abbreviation] J Fr Ophtalmol

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] France

   

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenocarcinoma of the prostate metastatic to the testis via lymphatic invasion: a case report.

[MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Testicular Neoplasms / secondary

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(PMID = 15779601.001).

[ISSN] 0010-6178

[Journal-full-title] Connecticut medicine

[ISO-abbreviation] Conn Med

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic prostate adenocarcinoma presenting with pulmonary symptoms: a case report and review of the literature.

INTRODUCTION: Prostate cancer has a high tendency to spread to bone.

Few patients with prostate cancer present initially with symptomatic metastatic lung lesions and lymphadenopathy without any other concomitant distant dissemination.

Despite the absence of any detectable osseous lesions and with the presence of multiple hilar, mediastinal, para-aortic, and pelvic lymphadenopathy, the patient had a complete work-up in search for the primary adenocarcinoma.

His prostate specific antigen was 146 ng/ml and a prostatic biopsy done, revealing an acinar prostatic adenocarcinoma.

A tru-cut biopsy of a lung lesion under computed tomography guidance showed a metastatic prostatic adenocarcinoma positive for prostate specific antigen stain.

CONCLUSION: This case sheds light on an unusual metastatic pattern of prostatic adenocarcinoma.

It also emphasizes the importance of including prostate cancer in the differential diagnosis of men with adenocarcinoma of unknown origin.

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[Cites] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387.001]

[Cites] Urol Oncol. 2006 May-Jun;24(3):216-9 [16678051.001]

[Cites] Urol Int. 1998 Oct;61(1):17-21 [9792977.001]

[Cites] Cancer. 1995 Jun 1;75(11):2706-9 [7743474.001]

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(PMID = 19014682.001).

[ISSN] 1757-1626

[Journal-full-title] Cases journal

[ISO-abbreviation] Cases J

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2590613

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Invasive adenocarcinoma of the prostate with urethral tumor.

Metastases of prostate cancer to the penis and urethra are rare and often represent advanced disease.

We describe a case of newly diagnosed prostatic adenocarcinoma with metastases to the corpus spongiosum, cavernosum, and the anterior urethra.

His prostate-specific antigen level was 5.02 ng/mL.

Digital rectal examination disclosed stony hard tumors at both lobes of the prostate.

Transrectal ultrasound-guided biopsy of the prostate revealed adenocarcinoma over both lobes; the Gleason score was 4 + 4 = 8.

Cystoscopy showed a penile urethral tumor and biopsy disclosed metastatic adenocarcinoma of the prostate; the Gleason score was 4 + 4 = 8.

[MeSH-major] Adenocarcinoma / pathology. Prostatic Neoplasms / pathology. Urethral Neoplasms / secondary

[MeSH-minor] Aged. Humans. Male. Prognosis. Prostate-Specific Antigen / blood

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[Copyright] Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.

(PMID = 20171591.001).

[ISSN] 1728-7731

[Journal-full-title] Journal of the Chinese Medical Association : JCMA

[ISO-abbreviation] J Chin Med Assoc

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] China (Republic : 1949- )

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Diagnostic utility of p501s (prostein) in comparison to prostate specific antigen (PSA) for the detection of metastatic prostatic adenocarcinoma.

BACKGROUND: Immunohistochemical detection of prostate specific antigen (PSA) is widely used to identify metastatic prostatic adenocarcinoma.

However, PSA may not be expressed in some poorly differentiated prostatic carcinomas and its immunoreactivity has been found in some non-prostatic tissues.

P501s (prostein) is a prostate-specific marker that is expressed in the cytoplasm of benign and malignant prostatic glandular cells.

The purpose of this study was to evaluate the expression of P501s in metastatic prostatic adenocarcinoma and compare its expression with PSA.

The TMA is constructed with normal donor prostates (NDP), prostatic adenocarcinoma (PRCA), non-neoplastic prostatic tissues adjacent to malignant glands (NAT), benign prostatic hyperplasia (BPH), high-grade prostatic neoplasia (PIN), metastatic adenocarcinoma to lymph nodes (MLN), metastatic adenocarcinoma to other sites (MC), and samples of benign testis, colon, adrenal and kidney.

The two groups of metastatic lesions were also subjected to stains with antibodies to PSA.

Although the metastatic lesions demonstrated similar rate of negative expression with PSA antibody, only 2 MC cases (3.3%) showed simultaneous negative stains for both P501S and PSA.

CONCLUSION: P501s is an organ specific marker for benign and malignant prostatic epithelial cells.

Its characteristic cytoplasmic stain pattern provides an additional valuable immunomarker for detection of metastatic prostatic malignancy, even though the intensity of its expression is reduced, as in the case with PSA.

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[Cites] Breast Cancer Res Treat. 1999 Jul;56(2):169-76 [10573109.001]

[Cites] CA Cancer J Clin. 1999 Jan-Feb;49(1):8-31, 1 [10200775.001]

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[Cites] Diagn Cytopathol. 2000 Sep;23(3):199-201 [10945910.001]

(PMID = 17963516.001).

[ISSN] 1746-1596

[Journal-full-title] Diagnostic pathology

[ISO-abbreviation] Diagn Pathol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2174437

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Erythrocyte membrane permeability in the men with metastatic adenocarcinoma of the prostate.

The aim of our study was to investigate the alterations of the erythrocyte membrane permeability in the men with metastatic adenocarcinoma of the prostate before and six months after castration.

For experimental research were used the erythrocytes of 15 men with metastatic prostate cancer (Pca) (before and after 6 months from castration) and of the 15 practically healthy men (control group).

Investigations revealed the changes of Na(+)/K(+)-ATP-ase activity and the changes of Na(+) and K(+) ions concentration in metastatic Pca patients before and six months after castration.

[MeSH-major] Adenocarcinoma / metabolism. Cell Membrane Permeability / physiology. Erythrocyte Membrane / metabolism. Prostatic Neoplasms / metabolism. Sodium-Potassium-Exchanging ATPase / metabolism

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Hazardous Substances Data Bank. POTASSIUM, ELEMENTAL .

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(PMID = 19202209.001).

[ISSN] 1512-0112

[Journal-full-title] Georgian medical news

[ISO-abbreviation] Georgian Med News

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] Georgia (Republic)

[Chemical-registry-number] 9NEZ333N27 / Sodium; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase; RWP5GA015D / Potassium

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Dynamics of the structural and electrical characteristics of erythrocytes in men with metastatic adenocarcinoma of the prostate before and after plastic orchiectomy.

The changes of electrophoretic mobility of erythrocytes in the practically healthy men and in men with metastatic prostate cancer before and after castration were studied.

Investigation revealed, that the level of electrophoretic mobility of erythrocytes was decreased in the blood of metastatic prostate cancer patients (before castration), as compared with control group and with post operational period data.

It was found, that during the malignant adenocarcinoma of prostate (before and after surgery) pathological changes in organism effect erythrocytes superficial membranes and alter their electrical and structural parameters.

Probably, that is one of the reasons of considerable decrease of erythrocytes electrophoretic mobility in patients with metastatic prostate adenocarcinoma (before castration).

[MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Erythrocytes / metabolism. Erythrocytes / ultrastructure. Orchiectomy / methods. Postoperative Care. Preoperative Care. Prostatic Neoplasms / secondary. Prostatic Neoplasms / surgery

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(PMID = 18250488.001).

[ISSN] 1512-0112

[Journal-full-title] Georgian medical news

[ISO-abbreviation] Georgian Med News

[Language] eng

[Publication-type] Journal Article

[Publication-country] Georgia (Republic)

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Maxillary metastasis revealing a prostate cancer].

[Transliterated title] Métastase maxillaire révélatrice d'un cancer de prostate.

CASE: A 57 year-old-man presented with a maxillary tumor which proved to be an adenocarcinoma.

The prostate was hard and PSA were high.

Biopsy confirmed the diagnosis of metastatic prostatic adenocarcinoma.

DISCUSSION: Facial bone metastases are rare comparatively to the high metastatic incidence in the rest of the skeleton.

[MeSH-major] Adenocarcinoma / secondary. Maxillary Neoplasms / secondary. Prostatic Neoplasms / pathology

[MeSH-minor] Fatal Outcome. Humans. Male. Middle Aged. Prostate-Specific Antigen / blood

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(PMID = 17881024.001).

[ISSN] 0035-1768

[Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale

[ISO-abbreviation] Rev Stomatol Chir Maxillofac

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] France

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Collet-Sicard syndrome: a rare presentation of metastatic prostate adenocarcinoma.

Metastatic spread of prostate adenocarcinoma to the temporal bone is rare.

A case of metastatic prostate adenocarcinoma involving the temporal bone causing a Collet-Sicard syndrome associated with an ipsilateral lower motor facial palsy and a mixed sensorineural and conductive hearing loss is presented.

This case highlights the potential of prostate adenocarcinoma to cause symptoms referable to the temporal bone region and histopathologic analysis of biopsy material should include immunohistochemical staining for prostate specific antigen.

[MeSH-major] Adenocarcinoma / secondary. Cranial Nerve Diseases / etiology. Prostatic Neoplasms / pathology. Skull Neoplasms / secondary. Temporal Bone

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(PMID = 15885949.001).

[ISSN] 0385-8146

[Journal-full-title] Auris, nasus, larynx

[ISO-abbreviation] Auris Nasus Larynx

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Netherlands

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate.

BACKGROUND: Adenocarcinoma of the prostate can present as metastatic carcinoma with no known primary.

Prostatic origin can be confirmed in most of these cases by immunohistochemistry for prostate-specific antigen (PSA) and prostate-specific acid phosphatase.

In a small subset of high-grade prostate carcinomas, both markers are negative and therefore are not helpful for confirming prostatic origin.

Recently, novel marker proteins that are preferentially expressed in prostate tissue were identified.

It is expressed in both benign and neoplastic prostate tissues, but not in any other normal or malignant tissue examined to date.

Owing to its apparent specificity, prostein may be a good marker to demonstrate prostatic origin in metastatic prostate cancer.

The tissue microarray contains 78 cases of metastatic prostatic adenocarcinoma, 20 cases of primary prostatic adenocarcinoma, and 20 cases of benign prostate tissue from the peripheral zone as well as samples of benign brain, pancreas, kidney, thyroid, testis, skeletal muscle, and fibroconnective tissue.

RESULTS: Similar staining (intensity and extent) was identified for both markers in the majority of metastatic tumors (11 distant sites, 42 pelvic lymph nodes), in all 20 primary tumors and in all benign prostate and nonprostate tissues.

In summary, 67 of the 69 cases (97%) of metastatic prostate carcinomas were PSA positive, whereas 68 of the 69 cases showed at least focal weak reactivity for P501S (99%).

CONCLUSIONS: Immunohistochemistry for P501S is a sensitive and highly specific marker for identifying prostate tissue.

The large majority of metastatic prostatic adenocarcinomas are P501S positive (99%).

A small subset of metastatic prostatic adenocarcinoma shows significant differences in staining intensity and extent for PSA and P501S and, therefore, combined use of these markers may result in increased sensitivity for detecting prostatic origin.

[MeSH-major] Adenocarcinoma / diagnosis. Membrane Proteins / analysis. Neoplasms, Unknown Primary / diagnosis. Prostate-Specific Antigen / analysis. Prostatic Neoplasms / diagnosis

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(PMID = 17721190.001).

[ISSN] 0147-5185

[Journal-full-title] The American journal of surgical pathology

[ISO-abbreviation] Am. J. Surg. Pathol.

[Language] eng

[Grant] United States / NCI NIH HHS / CA / P50 CA58236

[Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / Membrane Proteins; 0 / prostein; EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Prostate adenocarcinoma metastatic to penis].

[Transliterated title] Adenocarcinoma de próstata metastático a pene.

Prostate cancer is a disease that appears with a very high frequency.

We present one case of a patient with painless metastatic nodules on the penis secondary to a prostate cancer.

[MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Prostatic Neoplasms / pathology

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[CommentIn] Actas Urol Esp. 2006 Oct;30(9):962-4 [17175940.001]

(PMID = 17078582.001).

[ISSN] 0210-4806

[Journal-full-title] Actas urologicas españolas

[ISO-abbreviation] Actas Urol Esp

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article; Review

[Publication-country] Spain

[Number-of-references] 6

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic role of somatostatin receptor subtypes in human prostate cancer.

: e16120 Background: Neuroendocrine differentiation (NED) in prostate carcinoma (PC) is frequently detected by immunohistochemistry as single cells in conventional adenocarcinoma.

METHODS: PC tissues were reviewed from 100 pts who had undergone biopsy or radical prostatectomy for previously untreated advanced or metastatic PC from 2002 to 2007.

The absence of SSTR 1 and 5 in more aggressive disease could represent a growth advantage in NED prostate cancer.

SSTRs and somatostatin analogs are potential targets for prostate cancer treatment.

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(PMID = 27963398.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

: e20672 Background: Myelophthisis is a form of bone marrow failure due to replacement of hematopoietic tissue by abnormal tissue, most commonly metastatic carcinomas.

Twenty-seven pts (30%) had breast cancer, pathology followed by primary unknown tumours (21%), rabdomiosarcoma (10%), prostate adenocarcinoma (10%), gastric carcinoma (7%) and others (22%).

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(PMID = 27961689.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

The expression of Id1 in human cancer has been related to poor prognosis breast, prostate (Gil-Bazo, Amer Soc Clin Oncol GU.

2009) and other non-adenocarcinoma tumors.

CONCLUSIONS: For the first time using a MoAb against Id1 and in accord with our previous observations in prostate cancer the selection of PP pts increases tumor cell Id1 exp. from 28 up to 80%.

Id1 exp. profile in PP and metastatic initiation of BCa needs further research.

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(PMID = 27963310.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Distribution of high chromogranin A serum levels in patients with nonmetastatic and metastatic prostate adenocarcinoma.

OBJECTIVES: We analyzed the incidence of elevated serum levels of chromogranin A (CgA) (as marker of neuroendocrine activity) in nonmetastatic and metastatic prostate cancer populations.

MATERIAL AND METHODS: 264 consecutive men with nonmetastatic prostate adenocarcinoma considered for radical prostatectomy (group 1) and 89 consecutive men with metastatic prostate adenocarcinoma (group 2) represented our population.

The OR for CgA level >60 and >90 ng/ml significantly increased from nonmetastatic to metastatic cases (p = 0.0001).

CONCLUSIONS: We describe a significant incidence of elevated serum levels of CgA either in nonmetastatic (using 60 ng/ml as cut-off) or in metastatic (using 90 ng/ml as cut-off) prostate adenocarcinoma cases.

[MeSH-major] Adenocarcinoma / blood. Biomarkers, Tumor / blood. Chromogranin A / blood. Prostatic Neoplasms / blood

[MeSH-minor] Aged. Aged, 80 and over. Cell Differentiation. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Odds Ratio. Prospective Studies. Prostate-Specific Antigen / blood. Risk Assessment. Up-Regulation

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[Copyright] Copyright 2009 S. Karger AG, Basel.

(PMID = 19321999.001).

[ISSN] 1423-0399

[Journal-full-title] Urologia internationalis

[ISO-abbreviation] Urol. Int.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] Switzerland

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] NKX3.1 as a marker of prostatic origin in metastatic tumors.

NKX3.1 is a prostatic tumor suppressor gene located on chromosome 8p.

Although most studies have shown that staining for NKX3.1 protein is positive in the majority of primary prostatic adenocarcinomas, it has been shown to be downregulated in many high-grade prostate cancers, and completely lost in the majority of metastatic prostate cancers (eg, in 65% to 78% of lesions).

A recent study showed that NKX3.1 staining with a novel antibody was highly sensitive and specific for high-grade prostatic adenocarcinoma when compared with high-grade urothelial carcinoma.

This raised the question that this antibody may perform better than earlier used antibodies in metastatic prostate tumors.

However, the sensitivity and specificity for prostate carcinomas for this antibody in metastatic lesions was not determined.

Although prostate-specific antigen (PSA) and prostatic-specific acid phosphatase (PSAP) are excellent tissue markers of prostate cancer, at times they may be expressed at low levels, focally, or not at all in poorly differentiated primary and metastatic prostatic adenocarcinomas.

The purpose of this study was to determine the performance of NKX3.1 as a marker of metastatic adenocarcinoma of prostatic origin.

Immunohistochemical staining against NKX3.1, PSA, and PSAP was carried out on a tissue microarray (TMA) (0.6-mm tissue cores) of hormone naïve metastatic prostate adenocarcinoma specimens from lymph nodes, bone, and soft tissue.

To determine the specificity of NKX3.1 for prostatic adenocarcinoma, we used TMAs that contained cancers from various sites including the urinary bladder, breast, colon, salivary gland, stomach, pancreas, thyroid, and central nervous system, and standard paraffin sections of cancers from other sites including the adrenal cortex, kidney, liver, lung, and testis.

The sensitivity for identifying metastatic prostatic adenocarcinomas overall was 98.6% (68/69 cases positive) for NKX3.1, 94.2% (65/69 cores positive) for PSA, and 98.6% (68/69 cores positive) for PSAP.

NKX3.1 seems to be a highly sensitive and specific tissue marker of metastatic prostatic adenocarcinoma.

In the appropriate clinical setting, the addition of IHC staining for NKX3.1, along with other prostate-restricted markers, may prove to be a valuable adjunct to definitively determine prostatic origin in poorly differentiated metastatic carcinomas.

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[Cites] J Urol. 2000 Mar;163(3):972-9 [10688034.001]

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(PMID = 20588175.001).

[ISSN] 1532-0979

[Journal-full-title] The American journal of surgical pathology

[ISO-abbreviation] Am. J. Surg. Pathol.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA058236-16; United States / NCI NIH HHS / CA / P50 CA058236; United States / NCI NIH HHS / CA / P30 CA006973; United States / NCI NIH HHS / CA / P50 CA058236-16; United States / NCI NIH HHS / CA / P50 CA058236-07; United States / NCI NIH HHS / CA / P50 CA58236

[Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Homeodomain Proteins; 0 / NKX3-1 protein, human; 0 / Transcription Factors; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen

[Other-IDs] NLM/ NIHMS272269; NLM/ PMC3072223

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Intracranial metastasis from prostatic adenocarcinoma simulating a meningioma.

We report an unusual case of extra-axial metastatic adenocarcinoma of the prostate that closely simulated a frontal, parasagittal, dural-based meningioma.

Such tumours, which satisfy several criteria for a diagnosis of meningioma, but which have proved instead to be metastatic adenocarcinoma of the prostate, form the focus of our report.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Brain Neoplasms / diagnosis. Brain Neoplasms / secondary. Prostatic Neoplasms / pathology

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(PMID = 16351616.001).

[ISSN] 0004-8461

[Journal-full-title] Australasian radiology

[ISO-abbreviation] Australas Radiol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Australia

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Tumor lysis syndrome in a patient with metastatic, androgen independent prostate cancer.

We report a case of TLS in a patient with metastatic adenocarcinoma of the prostate after treatment with paclitaxel chemotherapy.

[MeSH-major] Adenocarcinoma / therapy. Antineoplastic Agents, Phytogenic / adverse effects. Paclitaxel / adverse effects. Prostatic Neoplasms / therapy. Tumor Lysis Syndrome / etiology

[MeSH-minor] Bone Marrow Neoplasms / drug therapy. Bone Marrow Neoplasms / secondary. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Hematuria / etiology. Humans. Hydronephrosis / etiology. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Male. Middle Aged. Prostate-Specific Antigen / blood. Renal Dialysis. Renal Insufficiency / etiology. Renal Insufficiency / therapy

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(PMID = 16351664.001).

[ISSN] 0919-8172

[Journal-full-title] International journal of urology : official journal of the Japanese Urological Association

[ISO-abbreviation] Int. J. Urol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Australia

[Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; EC 3.4.21.77 / Prostate-Specific Antigen; P88XT4IS4D / Paclitaxel

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic prostatic adenocarcinoma mimicking inflammatory breast carcinoma: a case report.

Prostate adenocarcinoma can manifest as a fairly indolent tumor or as a very aggressive cancer with significant invasive and metastatic potential.

Common metastatic sites include bone, liver, lymph nodes, and adrenal glands.

We present a case of a man who presented with breast skin changes that mimicked inflammatory breast carcinoma with specialized testing ultimately giving a diagnosis of metastatic prostatic adenocarcinoma.

A skin biopsy showed metastatic carcinoma in dermal lymphatics, and the tumor was found to have no estrogen or progesterone receptors or HER2 expression.

Subsequent immunohistochemical staining on the tumor specimen was positive for prostate-specific antigen (PSA) and alpha-methyl-CoA-racemase, confirming a diagnosis of metastatic prostatic adenocarcinoma.

Prostatic adenocarcinoma presenting initially as a breast malignancy is a rarely recognizable clinical event.

[MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms, Male / secondary. Prostatic Neoplasms / pathology

[MeSH-minor] Aged. Anilides / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Capecitabine. Carotid Stenosis / complications. Coronary Artery Disease / complications. Cyclophosphamide / administration & dosage. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Diabetes Mellitus. Fluorouracil / administration & dosage. Fluorouracil / analogs & derivatives. Humans. Immunohistochemistry. Leuprolide / administration & dosage. Male. Nitriles / administration & dosage. Osteoarthritis / complications. Positron-Emission Tomography. Prostate-Specific Antigen / analysis. Pulmonary Disease, Chronic Obstructive / complications. Tomography, X-Ray Computed. Tosyl Compounds / administration & dosage

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(PMID = 20133250.001).

[ISSN] 1938-0666

[Journal-full-title] Clinical breast cancer

[ISO-abbreviation] Clin. Breast Cancer

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Anilides; 0 / Nitriles; 0 / Tosyl Compounds; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; 8N3DW7272P / Cyclophosphamide; A0Z3NAU9DP / bicalutamide; EC 3.4.21.77 / Prostate-Specific Antigen; EFY6W0M8TG / Leuprolide; U3P01618RT / Fluorouracil

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Treatment of metastatic prostate adenocarcinoma to the calcaneus.

Metastatic skeletal adenocarcinoma is an all too common and unfortunate complication of advanced oncologic states.

The foot and ankle are uncommon sites for metastatic deposits, but may occur.

A team approach is mandatory to manage the patients with metastatic disease.

We present a case of an elderly male with a known history of prostate cancer, who presented with unrelenting heel pain, which upon diagnostic work-up, proved to be progressive calcaneal as well as axial metastasis after a brief period of clinical remission.

[MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Bone Neoplasms / secondary. Bone Neoplasms / therapy. Calcaneus. Prostatic Neoplasms / pathology

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[Copyright] Copyright 2010 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

(PMID = 20015665.001).

[ISSN] 1542-2224

[Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

[ISO-abbreviation] J Foot Ankle Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic adenocarcinoma of prostate in a healing sternotomy site.

Metastatic prostate cancer has a strong predilection for osseous sites, where the disease spreads in 80% of advanced cases.

The molecular mechanisms involved in prostate cancer establishment in bone are largely unknown; however, local tissue factors, including those involved in wound healing, have been suggested to play a critical role.

We present a case of tumor explosion in a median sternotomy wound after local prostate cancer therapy.

This case highlights that novel therapeutic interventions that disrupt the apparent synergistic relationship between tumor cells and the pro-tumorigenic microenvironment may hold great promise in constraining the proliferation of prostate cancer metastases.

[MeSH-major] Adenocarcinoma / secondary. Bone Neoplasms / secondary. Prostatic Neoplasms / pathology. Sternum / surgery. Wound Healing

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(PMID = 16808964.001).

[ISSN] 1527-9995

[Journal-full-title] Urology

[ISO-abbreviation] Urology

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Multiple cranial neuropathy as the initial presentation of metastatic prostate adenocarcinoma: case report and review of literature.

The skull base is an atypical metastatic site for prostate carcinoma.

However, skull base involvement causing cranial nerve palsies may rarely be the presenting sign of prostate carcinoma.

Here, we describe an unusual case of prostate adenocarcinoma presenting as a central skull base tumour with multiple cranial neuropathy.

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(PMID = 20379748.001).

[ISSN] 0942-0940

[Journal-full-title] Acta neurochirurgica

[ISO-abbreviation] Acta Neurochir (Wien)

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Austria

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Case report: gastric adenocarcinoma metastatic to the prostate gland.

Metastasis to the prostate gland from gastric cancer is exceedingly rare.

We have presented a rare case of gastric malignancy metastasizing to the prostate diagnosed by transrectal ultrasound guided prostate biopsy.

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(PMID = 22470718.001).

[ISSN] 1943-0922

[Journal-full-title] Journal of radiology case reports

[ISO-abbreviation] J Radiol Case Rep

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC3303380

[Keywords] NOTNLM ; gastric adenocarcinoma / metastases / secondary prostatic cancer / transrectal ultrasound

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic prostatic adenocarcinoma in an inguinal hernia sac in a patient with undetectable serum prostate specific antigen level.

Metastatic prostate cancer found within the hernia sac contents is a rare clinical manifestation.

We report a 64-year-old male patient who presented with rare clinical features of prostate cancer.

A focal metastasis of prostate cancer was incidentally found in an incised inguinal hernia sac 5 years after radical prostatectomy.

The serum prostate specific antigen (PSA) level remained undetectable (<0.01 ng/mL) prior to herniorrhaphy without any adjuvant therapy.

However, his serum PSA level started rising 12 months later and bladder invasion as well as a mass in the cul-de-sac was identified subsequently.

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(PMID = 17561475.001).

[ISSN] 0929-6646

[Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi

[ISO-abbreviation] J. Formos. Med. Assoc.

[Language] ENG

[Publication-type] Case Reports; Journal Article

[Publication-country] Singapore

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Hormone refractory prostate carcinoma metastasizes to the penis: a case report].

At 67-years-old, he was diagnosed with stage D2 prostate cancer and then, was treated with hormone therapy.

Several nodules were observed on the glans, and histological examination of the penile tumor biopsy showed metastatic adenocarcinoma of the prostate.

For the purpose of maintaining quality of life, transurethral resection of the prostate and partial penectomy were done.

[MeSH-major] Adenocarcinoma / pathology. Penile Neoplasms / secondary. Prostatic Neoplasms / pathology

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(PMID = 19938335.001).

[ISSN] 0018-1994

[Journal-full-title] Hinyokika kiyo. Acta urologica Japonica

[ISO-abbreviation] Hinyokika Kiyo

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Androgen Antagonists

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Incidence of high chromogranin A serum levels in patients with non metastatic prostate adenocarcinoma.

BACKGROUND: ChromograninA in prostate carcinoma (PC) indicate NE differentiation.

PATIENTS AND METHODS: We analyzed the incidence of pre-operative ChromograninA serum levels in non metastatic PC patients.

[MeSH-major] Adenocarcinoma / blood. Biomarkers, Tumor / blood. Chromogranin A / blood. Prostatic Neoplasms / blood

[MeSH-minor] Adult. Aged. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Prostate-Specific Antigen / blood. Retrospective Studies

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[Cites] Prostate. 2000 Mar 1;42(4):274-9 [10679756.001]

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(PMID = 21162758.001).

[ISSN] 1756-9966

[Journal-full-title] Journal of experimental & clinical cancer research : CR

[ISO-abbreviation] J. Exp. Clin. Cancer Res.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; EC 3.4.21.77 / Prostate-Specific Antigen

[Other-IDs] NLM/ PMC3018395

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic prostate cancer masquerading clinically and radiologically as a primary caecal carcinoma.

BACKGROUND: Prostatic carcinoma is the second most common cause of cancer-related deaths in males in the West.

Approximately 20% of patients present with metastatic disease.

We describe the case of a patient with metastatic prostate cancer to the bowel presenting clinically and radiologically as a primary caecal cancer.

The patient was being treated (Zoladex) for prostatic cancer diagnosed 6 years previously and was known to have bony metastases.

Histology showed a poorly differentiated adenocarcinoma which was PSA positive, confirming metastatic prostatic adenocarcinoma to the caecum.

CONCLUSION: Metastasis of prostatic carcinoma to the bowel is a very rare occurrence and presents a challenging diagnosis.

The treatment for metastatic prostate cancer is mainly palliative.

[MeSH-major] Adenocarcinoma / secondary. Cecal Neoplasms / secondary. Cecal Neoplasms / therapy. Prostatic Neoplasms / pathology

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(PMID = 17207288.001).

[ISSN] 1477-7819

[Journal-full-title] World journal of surgical oncology

[ISO-abbreviation] World J Surg Oncol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC1779271

[General-notes] NLM/ Original DateCompleted: 20070802

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Brain metastases from prostate adenocarcinoma.

Brain metastases of prostate adenocarcinoma are rare.

We report a case of brain metastases from prostate adenocarcinoma 15 months after the diagnosis of the primary tumour.

The biopsy performed showed metastatic prostate adenocarcinoma.

[MeSH-major] Adenocarcinoma / secondary. Brain Neoplasms / secondary. Prostatic Neoplasms / pathology

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(PMID = 19155207.001).

[ISSN] 1699-048X

[Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

[ISO-abbreviation] Clin Transl Oncol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A phase II study of paclitaxel poliglumex in combination with transdermal estradiol for the treatment of metastatic castration-resistant prostate cancer after docetaxel chemotherapy.

Taxanes remain the only agents to extend survival in castration-resistant metastatic prostate cancer, but their impact on the natural history of this disease is modest.

Patients with metastatic adenocarcinoma of the prostate who progressed despite standard hormonal therapy and after docetaxel-containing chemotherapy were treated with transdermal estradiol (0.2 mg/24 h) for 4 weeks followed by the same dose of transdermal estradiol and paclitaxel poliglumex (PPX; 150 mg/m intravenous) every 28 days.

The primary objective was to determine the level of activity of the regimen measured using a fraction of patients who experienced a confirmed decline in serum prostate-specific antigen (PSA) of 50% or more.

In conclusion, this regimen of low-dose transdermal estradiol induction followed by PPX does not have activity in taxane pretreated patients with castration-resistant prostate cancer.

[MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Estradiol / therapeutic use. Paclitaxel / analogs & derivatives. Polyglutamic Acid / analogs & derivatives. Prostatic Neoplasms / drug therapy

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(PMID = 20016365.001).

[ISSN] 1473-5741

[Journal-full-title] Anti-cancer drugs

[ISO-abbreviation] Anticancer Drugs

[Language] eng

[Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Taxoids; 0 / paclitaxel poliglumex; 15H5577CQD / docetaxel; 25513-46-6 / Polyglutamic Acid; 4TI98Z838E / Estradiol; P88XT4IS4D / Paclitaxel

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Extranodal Rosai-Dorfman disease of the kidney and coexistent poorly differentiated prostatic adenocarcinoma.

We present a case of a patient who was initially diagnosed with poorly differentiated prostatic adenocarcinoma on prostate needle core biopsy.

Positron emission tomographic scan showed increased uptake in para-aortic, paracaval, and retrocaval lymph nodes suspicious for metastatic disease.

Lymphadenectomy revealed metastatic prostatic adenocarcinoma; however, the lymph nodes did not show evidence of Rosai-Dorfman disease.

The combination of prostatic adenocarcinoma and isolated extranodal Rosai-Dorfman disease of the kidney makes this case unique.

[MeSH-major] Adenocarcinoma / complications. Histiocytosis, Sinus / complications. Kidney Diseases / complications. Prostatic Neoplasms / complications

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(PMID = 16879029.001).

[ISSN] 1543-2165

[Journal-full-title] Archives of pathology & laboratory medicine

[ISO-abbreviation] Arch. Pathol. Lab. Med.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Biomarkers, Tumor

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Collet-sicard syndrome: an uncommon manifestation of metastatic prostate cancer.

Metastatic spread of prostate adenocarcinoma to the temporal bone is very rare.

A case of metastatic prostate adenocarcinoma involving the temporal bone causing Collet-Sicard syndrome is presented.

This case highlights an uncommon manifestation of prostate adenocarcinoma causing symptoms referable to the occipital condyle of the temporal bone.

Few cases have been reported in the literature of Collet-Sicard syndrome due to metastatic prostate cancer.

[MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Skull Neoplasms / secondary. Temporal Bone

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(PMID = 16929891.001).

[ISSN] 0038-4348

[Journal-full-title] Southern medical journal

[ISO-abbreviation] South. Med. J.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Combined radiotherapy and hormone therapy in non-metastatic adenocarcinoma of prostate].

[Transliterated title] Hormono-radiothérapie des adénocarcinomes non métastatiques de la prostate.

Non-metastatic adenocarcinoma of prostate can be cured in the vast majority of cases with surgery and/or external or interstitial radiotherapy.

Analysis of results of recent randomised trials comparing this association and exclusive radiotherapy allows for validating concept of combined radiotherapy and hormone therapy in locally advanced adenocarcinoma of prostate, while many questions should be more clearly answered.

[MeSH-major] Androgen Antagonists / therapeutic use. Neoplasms, Hormone-Dependent / drug therapy. Neoplasms, Hormone-Dependent / radiotherapy. Prostatic Neoplasms / drug therapy. Prostatic Neoplasms / radiotherapy

[MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Chemotherapy, Adjuvant. Combined Modality Therapy / methods. Gonadotropin-Releasing Hormone / analogs & derivatives. Humans. Male. Neoplasm Recurrence, Local / prevention & control. Prostate-Specific Antigen / blood

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(PMID = 19318304.001).

[ISSN] 1769-6917

[Journal-full-title] Bulletin du cancer

[ISO-abbreviation] Bull Cancer

[Language] fre

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] France

[Chemical-registry-number] 0 / Androgen Antagonists; 33515-09-2 / Gonadotropin-Releasing Hormone; EC 3.4.21.77 / Prostate-Specific Antigen

[Number-of-references] 40

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Cytology of metastatic prostate cancer following orchiectomy and antiandrogen therapy: a diagnostic challenge.

Androgen deprivation therapy induces apoptosis and decreases both cell proliferation and angiogenesis in prostate adenocarcinoma.

The molecular alterations following androgen ablation translate into unique cytologic features in both primary and metastatic prostate adenocarcinoma.

We describe the cytologic appearance of metastatic prostate carcinoma following both surgical castration and androgen deprivation therapy.

[MeSH-major] Adenocarcinoma / pathology. Androgen Antagonists / therapeutic use. Biopsy, Fine-Needle. Orchiectomy. Prostatic Neoplasms / pathology

[MeSH-minor] Aged, 80 and over. Androgens / metabolism. Anilides / therapeutic use. Diagnosis, Differential. Histological Techniques. Humans. Male. Nitriles / therapeutic use. Prostate. Prostate-Specific Antigen / analysis. Tosyl Compounds / therapeutic use

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[Copyright] (c) 2008 Wiley-Liss, Inc.

(PMID = 18528888.001).

[ISSN] 1097-0339

[Journal-full-title] Diagnostic cytopathology

[ISO-abbreviation] Diagn. Cytopathol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Androgen Antagonists; 0 / Androgens; 0 / Anilides; 0 / Nitriles; 0 / Tosyl Compounds; A0Z3NAU9DP / bicalutamide; EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Epidermotropic metastatic prostate carcinoma presenting as an umbilical nodule-Sister Mary Joseph nodule.

Carcinoma of the prostate accounts for fewer than 1% of all skin metastases.

Cutaneous metastases from prostate carcinoma most often involve the penis, the anterior aspect of the thighs, the suprapubic area, and the perineum, but they also have been reported in the scalp, the chest, the back, and even the face.

We report an unusual case of metastatic prostate adenocarcinoma that presented as an umbilical nodule (Sister Mary Joseph nodule) and demonstrated significant epidermotropism histologically.

A review of the literature has found only one documented case of prostatic carcinoma metastasizing to the umbilicus, and one other documented case of epidermotropic metastatic prostate carcinoma.

[MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Skin Neoplasms / secondary. Umbilicus / pathology

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(PMID = 17519629.001).

[ISSN] 0193-1091

[Journal-full-title] The American Journal of dermatopathology

[ISO-abbreviation] Am J Dermatopathol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A retrospective review of combination chemohormonal therapy as initial treatment for locally advanced or metastatic adenocarcinoma of the prostate.

OBJECTIVE: Chemotherapy for hormone-refractory prostate cancer reduces PSA levels and enhances overall survival (OS), suggesting that administration in earlier disease stages may be beneficial.

If expansion of an androgen-independent clone present during androgen deprivation mediates the transformation from an androgen-dependent to an androgen-independent phenotype, combination chemohormonal therapy would be effective initial treatment for locally advanced or metastatic prostate cancers.

MATERIALS AND METHODS: Chemohormonal therapy outcomes were retrospectively evaluated in men with locally advanced or metastatic prostate cancer seen at our institution between January 2001 and February 2003.

CONCLUSIONS: Combination chemohormonal therapy for locally advanced or metastatic prostate cancer safely and effectively reduces PSA levels and increases OS.

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Agents, Hormonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Prostatic Neoplasms / drug therapy

[MeSH-minor] Adult. Aged. Humans. Male. Middle Aged. Neoplasm Metastasis. Phenotype. Prostate-Specific Antigen / metabolism. Retrospective Studies. Time Factors. Treatment Outcome

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(PMID = 18367115.001).

[ISSN] 1078-1439

[Journal-full-title] Urologic oncology

[ISO-abbreviation] Urol. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pseudomelanoma in a patient with prostate adenocarcinoma.

CASE REPORT: A 72-year-old man referred for evaluation of a uveal melanoma was revealed with primary prostate adenocarcinoma metastatic to the choroid.

COMMENTS: Differential diagnosis of choroidal tumours may be difficult but should include both uveal melanoma and metastatic carcinoma to the uvea.

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(PMID = 17392857.001).

[ISSN] 0008-4182

[Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

[ISO-abbreviation] Can. J. Ophthalmol.

[Language] ENG

[Publication-type] Case Reports; Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Antineoplastic Agents

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [A case of prostatic adenocarcinoma clinically presenting as supraclavicular and mediastinal lymphadenopathy].

We report a 70-year-old man with prostatic carcinoma presenting as supraclaviculer and mediastinal lymphadenopathy.

He had no urinary tract symptoms, and computed tomography and FDG-PET showed no abnormality in the prostate or pelvic lymph nodes.

Metastatic prostatic adenocarcinoma was finally diagnosed from the results of immunohistochemical staining for PSA of a biopsy specimen of the mediastinal lymph node, and he was treated by hormonal therapy.

Prostatic carcinoma should always be considered in the differential diagnosis of elderly men with supraclaviculer or mediastinal lymph node metastases, since appropriate treatment will lead to a prolonged survival.

[MeSH-major] Adenocarcinoma / diagnosis. Lymph Nodes / pathology. Lymphatic Diseases / diagnosis. Prostatic Neoplasms / diagnosis

[MeSH-minor] Aged. Biopsy, Needle. Humans. Lymphatic Metastasis. Male. Mediastinum. Prostate-Specific Antigen / blood

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(PMID = 17763696.001).

[ISSN] 1343-3490

[Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society

[ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic prostate carcinoma presenting as supraclavicular lymphadenopathy - is it unusual?

Prostate carcinoma presenting initially as supraclavicular lymphadenopathy has been increasingly reported as an uncommon presentation of the disease.

The diagnosis is often made on lymph node biopsy as these patients rarely undergo digital rectal examination or serum prostate-specific antigen level measurement as part of their initial investigations.

The diagnosis of metastatic prostate adenocarcinoma was made only after cervical lymph node biopsy.

Following the diagnosis, he was confirmed as having an abnormal prostate on digital rectal examination and a raised serum prostate-specific antigen level.

The authors propose that a digital rectal examination and a serum prostate specific antigen level be included in the initial investigation process of male patients with persistent supraclavicular lymphadenopathy.

[MeSH-major] Adenocarcinoma / secondary. Jugular Veins. Lymphatic Diseases / pathology. Prostatic Neoplasms. Thrombosis / etiology

[MeSH-minor] Aged. Digital Rectal Examination. Humans. Male. Prostate-Specific Antigen / analysis

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[Cites] Cancer. 1971 May;27(5):1055-63 [5581507.001]

[Cites] Am J Surg Pathol. 1987 Jun;11(6):457-63 [2438955.001]

[Cites] Br J Urol. 1984 Aug;56(4):385-90 [6534426.001]

(PMID = 17059705.001).

[ISSN] 1478-7083

[Journal-full-title] Annals of the Royal College of Surgeons of England

[ISO-abbreviation] Ann R Coll Surg Engl

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen

[Other-IDs] NLM/ PMC1963752

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Immunohistochemical staining of precursor forms of prostate-specific antigen (proPSA) in metastatic prostate cancer.

Precursors of prostate-specific antigen (proPSA) have been previously shown to be more concentrated in prostate cancer tissue.

This study characterizes the immunohistochemical staining (IHS) of proPSA forms in metastatic prostate cancer compared with prostate specific antigen (PSA) and prostatic acid phosphatase (PAP).

A tissue microarray, consisting of 74 cases of metastatic prostate carcinoma and control tissues, was used.

The monoclonal antibodies were specific for both benign and malignant prostatic glandular tissue.

[-5/-7]pPSA (native proPSA) may be a better marker than PSA and PAP in characterizing metastatic prostate adenocarcinoma, with most of the cases showing positivity for the marker.

Such enhanced detection is particularly important in poorly differentiated carcinomas involving metastatic sites where prostate carcinoma is a consideration.

A panel of markers, including proPSA, should be performed when metastatic prostate carcinoma is in the differential diagnosis.

[MeSH-major] Adenocarcinoma / chemistry. Immunoenzyme Techniques / methods. Prostate-Specific Antigen / analysis. Prostatic Neoplasms / chemistry. Protein Precursors / analysis. Protein Tyrosine Phosphatases / analysis

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(PMID = 17001152.001).

[ISSN] 0147-5185

[Journal-full-title] The American journal of surgical pathology

[ISO-abbreviation] Am. J. Surg. Pathol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protein Precursors; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma.

In prostate adenocarcinoma, 39 microRNAs are up-regulated, and six microRNAs are down-regulated.

From a gene array analysis of 16 normal prostate tissue samples, 64 organ-confined, and four metastatic prostate adenocarcinomas, we identified an up-regulation of major components of the microRNA machinery, including Dicer, in metastatic prostate adenocarcinoma.

Immunohistochemical studies on a tissue microarray consisting of 232 prostate specimens confirmed up-regulation of Dicer in prostatic intraepithelial neoplasia and in 81% of prostate adenocarcinoma.

The increased Dicer level in prostate adenocarcinoma correlated with clinical stage, lymph node status, and Gleason score.

Western blot analysis of benign and neoplastic prostate cell lines further confirmed Dicer up-regulation in prostate adenocarcinoma.

Dicer up-regulation may explain an almost global increase of microRNA expression in prostate adenocarcinoma.

The presence of up-regulated microRNA machinery may predict the susceptibility of prostate adenocarcinoma to RNA interference-based therapy.

[MeSH-major] Adenocarcinoma / enzymology. Adenocarcinoma / pathology. DEAD-box RNA Helicases / metabolism. Endoribonucleases / metabolism. MicroRNAs / metabolism. Prostatic Neoplasms / enzymology. Prostatic Neoplasms / pathology. Up-Regulation

[MeSH-minor] Adult. Aged. Aged, 80 and over. Blotting, Western. Cell Line, Tumor. Epithelium / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Microarray Analysis. Middle Aged. Prostate / cytology. Prostate / enzymology. Prostate / pathology. Ribonuclease III

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(PMID = 17071602.001).

[ISSN] 0002-9440

[Journal-full-title] The American journal of pathology

[ISO-abbreviation] Am. J. Pathol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / MicroRNAs; EC 3.1.- / Endoribonucleases; EC 3.1.26.3 / DICER1 protein, human; EC 3.1.26.3 / Ribonuclease III; EC 3.6.4.13 / DEAD-box RNA Helicases

[Other-IDs] NLM/ PMC1780192

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic ductal carcinoma of the prostate: a rare variant responding to a common treatment.

Ductal carcinoma of the prostate is a rare histologic subtype of prostate carcinoma.

It represents 0.4% to 0.8% of all prostate cancers and is associated with a poor prognosis.

Given the paucity of cases reported in the literature on ductal prostate carcinoma, little is known about how this cancer responds to cytotoxic chemotherapy.

We report the case of a 56-year-old male who presented to our clinic with hemoptysis, cough and hematuria and was found to have metastatic ductal carcinoma of the prostate.

He was initiated on docetaxel chemotherapy, which has been previously shown to improve overall survival in patients with metastatic prostate adenocarcinoma, but has never been studied in this less common subtype of prostate cancer.

To the best of our knowledge, the following is the first reported case of a patient with metastatic ductal carcinoma of the prostate responding to docetaxel chemotherapy.

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(PMID = 20368883.001).

[ISSN] 1920-1214

[Journal-full-title] Canadian Urological Association journal = Journal de l'Association des urologues du Canada

[ISO-abbreviation] Can Urol Assoc J

[Language] eng

[Publication-type] Journal Article

[Publication-country] Canada

[Other-IDs] NLM/ PMC2845672

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Weekly docetaxel and bortezomib as first-line treatment for patients with hormone-refractory prostate cancer: a Minnie Pearl Cancer Research Network phase II trial.

BACKGROUND: Docetaxel is currently the standard first-line treatment in patients with hormone-refractory prostate cancer (HRPC).

Bortezomib, the first proteasome inhibitor in clinical use, demonstrated activity against prostate cancer in phase I trials.

All patients had metastatic adenocarcinoma of the prostate that had progressed on hormonal therapy.

Fifteen patients (25%; 95% confidence interval, 15%-38%) had a > 50% decrease in serum prostate-specific antigen level with treatment; the median response duration was 8 months.

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Agents / administration & dosage. Boronic Acids / administration & dosage. Prostatic Neoplasms / drug therapy. Pyrazines / administration & dosage. Taxoids / administration & dosage

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(PMID = 17553208.001).

[ISSN] 1558-7673

[Journal-full-title] Clinical genitourinary cancer

[ISO-abbreviation] Clin Genitourin Cancer

[Language] eng

[Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Androgens; 0 / Antineoplastic Agents; 0 / Boronic Acids; 0 / Pyrazines; 0 / Taxoids; 15H5577CQD / docetaxel; 69G8BD63PP / Bortezomib

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prostate carcinoma metastasis to extraocular muscles.

Prostate carcinoma, when metastatic, typically involves bone and produces both osteoblastic and osteolytic changes.

Orbital involvement is uncommon and extraocular muscle enlargement is a rare presentation of metastatic prostate adenocarcinoma.

The authors present 2 patients with prostatic tumor metastasis to extraocular muscles.

Clinicians should be aware that, although rare, prostate cancer can involve the extraocular muscles.

[MeSH-major] Adenocarcinoma / secondary. Eye Neoplasms / secondary. Muscle Neoplasms / secondary. Oculomotor Muscles / pathology. Prostatic Neoplasms / pathology

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(PMID = 18520846.001).

[ISSN] 0740-9303

[Journal-full-title] Ophthalmic plastic and reconstructive surgery

[ISO-abbreviation] Ophthal Plast Reconstr Surg

[Language] eng

[Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Regression of a choroidal metastasis from prostate adenocarcinoma after hormonal therapy].

[Transliterated title] Regresión de una metástasis coroidea de adenocarcinoma de próstata con tratamiento hormonal.

CASE REPORT: We report a case of a patient diagnosed with prostatic adenocarcinoma with multiple bone metastases and a choroidal metastasis in his left eye.

No metastatic recurrence has been demonstrated after a follow-up period of 14 months.

DISCUSSION: Complete resolution of choroidal metastases of prostatic adenocarcinoma with hormonal therapy is exceptional, but the effect of this treatment on such metastases should be observed before recommending radiation therapy.

[MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Androgen Antagonists / therapeutic use. Anilides / therapeutic use. Antineoplastic Agents, Hormonal / therapeutic use. Choroid Neoplasms / secondary. Nitriles / therapeutic use. Prostatic Neoplasms / drug therapy. Tosyl Compounds / therapeutic use

[MeSH-minor] Aged. Biopsy. Bone Neoplasms / secondary. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Prostate / pathology. Prostate-Specific Antigen / blood. Time Factors. Treatment Outcome

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(PMID = 17979041.001).

[ISSN] 0365-6691

[Journal-full-title] Archivos de la Sociedad Española de Oftalmología

[ISO-abbreviation] Arch Soc Esp Oftalmol

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Spain

[Chemical-registry-number] 0 / Androgen Antagonists; 0 / Anilides; 0 / Antineoplastic Agents, Hormonal; 0 / Nitriles; 0 / Tosyl Compounds; A0Z3NAU9DP / bicalutamide; EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic patterns in adenocarcinoma.

BACKGROUND: Unique metastatic patterns cited in the literature often arise from anecdotal clinical observations and autopsy reports.

The authors analyzed clinical data from a large number of patients with histologically confirmed, distant-stage adenocarcinoma to evaluate metastatic patterns.

METHODS: Tumor registry data were collected between 1994-1996 on 11 primary tumor sites and 15 metastatic sites from 4399 patients.

The primary and metastatic sites were cross-tabulated in various ways to identify patterns, and the authors developed algorithms by using multinomial logistic regression analysis to predict the locations of primary tumors based on metastatic patterns.

RESULTS: Three primary tumors had single, dominant metastatic sites: ovary to abdominal cavity (91%), prostate to bone (90%), and pancreas to liver (85%).

The liver was the dominant metastatic site for gastrointestinal (GI) primary tumors (71% of patients), whereas bone and lung metastases were noted most frequently in non-GI primary tumors (43% and 29%, respectively).

In a study of combinations of liver, abdominal cavity, and bone metastases, 86% of prostate primary tumors had only bone metastases, 80% of ovarian primary tumors had only abdominal cavity metastases, and 74% of pancreas primary tumors had only liver metastases.

[MeSH-major] Adenocarcinoma / secondary. Algorithms. Neoplasm Metastasis. Registries / statistics & numerical data

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[Copyright] Copyright 2006 American Cancer Society.

(PMID = 16518827.001).

[ISSN] 0008-543X

[Journal-full-title] Cancer

[ISO-abbreviation] Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Fine needle aspiration biopsy diagnosis of metastatic prostate carcinoma to inguinal lymph node.

Carcinoma of the prostate is predominantly a disease of older men.

Men younger than 50 years of age account for approximately 1% of all patients diagnosed with prostate cancer.

Patients generally present with urinary symptoms and rarely with metastatic disease.

We report a case of an aggressive prostate adenocarcinoma in a 47-year-old white male who presented with nausea, vomiting, and enlarged inguinal lymph nodes for 1 month.

A fine needle aspiration biopsy (FNAB) and immunohistochemical stains performed on the FNAB revealed metastatic prostatic adenocarcinoma.

[MeSH-major] Adenocarcinoma / pathology. Lymph Nodes / pathology. Prostatic Neoplasms / pathology

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[Copyright] (c) 2007 Wiley-Liss, Inc.

(PMID = 17703448.001).

[ISSN] 8755-1039

[Journal-full-title] Diagnostic cytopathology

[ISO-abbreviation] Diagn. Cytopathol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Urothelial-type adenocarcinoma of the prostate mimicking metastatic colorectal adenocarcinoma.

Adenocarcinoma arising in urinary bladder or prostatic urethra is uncommon.

When they occur, the tumor can be mistaken for metastatic lesions, especially from the colon.

Here we report the fifth case of a primary urothelial-type adenocarcinoma arising in the prostate which showed enteric differentiation.

The patient was a 55 year-old male whose prostatic needle core biopsy showed a high grade adenocarcinoma which was initially thought to be metastatic colon cancer.

Subsequent prostatectomy revealed a high grade adenocarcinoma which was positive for cytokeratins 7 and 20, carcinoembryonic antigen, CDX2, and high molecular weight cytokeratin, and negative for prostate specific antigen, prostate specific acid phosphatase and AMACR.

A diagnosis of urothelial-type adenocarcinoma of the prostate was rendered.

[MeSH-major] Adenocarcinoma, Mucinous / pathology. Colorectal Neoplasms / pathology. Prostatic Neoplasms / pathology

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(PMID = 17201946.001).

[ISSN] 1677-5538

[Journal-full-title] International braz j urol : official journal of the Brazilian Society of Urology

[ISO-abbreviation] Int Braz J Urol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Brazil

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Metachronic testicular metastasis secondary to clear cell renal adenocarcinoma].

[Transliterated title] Metástasis testicular metacrónica secundaria a adenocarcinoma renal de células claras.

The pathology result was clear cell adenocarcinoma.

RESULTS: Six months later the patient continues under oral Sorafenib without evidence of new metastatic implants.

CONCLUSIONS: Testicular secondary metastatic tumors account for less than 1% of old testicular tumors.

In patients in the fifth and sixth decades, mainly if they are affected by other neoplasias, testicular masses use to be metastatic implants.

The most frequent origin is prostate.

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(PMID = 18592774.001).

[ISSN] 0004-0614

[Journal-full-title] Archivos españoles de urología

[ISO-abbreviation] Arch. Esp. Urol.

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Spain

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic prostatic carcinoma to testis: histological features mimicking lymphoma.

We report a case of prostatic carcinoma with testicular metastasis, which mimicked malignant lymphoma of the testis.

The patient was a 71 year-old man with a history of prostate adenocarcinoma of Gleason score 9 (4+5) diagnosed in 2001 for which he received hormonal therapy.

However, immunohistochemical stains were positive for prostate-specific antigen and prostate acid phosphatase and negative for leukocyte common antigen, which confirmed the diagnosis of metastatic prostate adenocarcinoma.

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[Cites] CA Cancer J Clin. 2006 Mar-Apr;56(2):106-30 [16514137.001]

[Cites] Arch Esp Urol. 1994 Dec;47(10):992-7 [7864681.001]

[Cites] Ann Urol (Paris). 1994;28(5):274-6 [7825987.001]

[Cites] Br J Urol. 1993 May;71(5):600-6 [8518870.001]

[Cites] J Urol. 1989 Oct;142(4):1003-5 [2677407.001]

[Cites] Acta Radiol Oncol. 1984;23(4):239-47 [6093440.001]

[Cites] Cancer. 1984 Aug 15;54(4):709-14 [6204734.001]

[Cites] Urology. 1984 Jun;23(6):598-9 [6730133.001]

[Cites] Histopathology. 1979 Jan;3(1):31-7 [428920.001]

[Cites] South Med J. 1971 Sep;64(9):1128-30 [5096298.001]

[Cites] Eur Urol. 2004 Apr;45(4):495-8 [15041115.001]

(PMID = 18830384.001).

[ISSN] 1936-2625

[Journal-full-title] International journal of clinical and experimental pathology

[ISO-abbreviation] Int J Clin Exp Pathol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Keywords] NOTNLM ; lymphoma / metastasis / prostate cancer / testis

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Clinical outcome of Taiwanese men with metastatic prostate cancer compared with other ethnic groups.

OBJECTIVES: Prostate cancer incidence varies significantly among different ethnic groups.

We sought to compare the survival outcome in patients with metastatic prostate cancer among different ethnic groups and to identify independent prognostic factors affecting overall survival in Taiwanese patients.

METHODS: From January 1996 to February 2005, 482 men with newly diagnosed metastatic prostate adenocarcinoma were enrolled from five major medical centers in Taiwan.

The cohort accounted for about 11.5% of all patients with metastatic disease during the period in Taiwan.

CONCLUSIONS: Taiwanese men with metastatic prostate cancer might have a better survival compared with Western men.

[MeSH-major] Prostatic Neoplasms / pathology. Prostatic Neoplasms / therapy

[MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Ethnic Groups. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Metastasis. Prostate-Specific Antigen / biosynthesis. Retrospective Studies. Taiwan. Treatment Outcome

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(PMID = 18372020.001).

[ISSN] 1527-9995

[Journal-full-title] Urology

[ISO-abbreviation] Urology

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Urinary bladder metastasis of prostate cancer : a case report].

A 62-year-old man was referred to our outpatient clinic because of his elevated serum prostatic specific antigen level.

The transrectal ultrasonography guided biopsy of the prostate revealed prostate cancer.

Transurethral resection of the bladder tumor was performed, and histopathological examination showed the bladder tumor composed of not urothelial carcinoma but metastatic adenocarcinoma from prostate cancer.

[MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Urinary Bladder Neoplasms / secondary

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(PMID = 20186001.001).

[ISSN] 0018-1994

[Journal-full-title] Hinyokika kiyo. Acta urologica Japonica

[ISO-abbreviation] Hinyokika Kiyo

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Place of surgery in high-risk tumours of the prostate].

[Transliterated title] Place de la chirurgie dans les tumeurs de la prostate à haut risque.

Among the different options recommended for high-risk prostate cancer, radical prostatectomy is admitted as radiotherapy, but its role is still controversial in monotherapy and difficult to evaluate in combined treatments.

The results of clinical trials combining an external radiotherapy to a long-term androgen deprivation in locally advanced tumours sustain the principle of a multidisciplinary management in high-risk prostate cancer.

Radical prostatectomy with an extended pelvic lymphadenectomy can be considered as a viable alternative to radiotherapy and hormonal therapy in these patients with a long life expectancy but presenting a high risk of local progression and a low risk of metastatic disease.

[MeSH-major] Adenocarcinoma / surgery. Prostatectomy. Prostatic Neoplasms / surgery

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[Copyright] Copyright © 2010 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

(PMID = 20727805.001).

[ISSN] 1769-6658

[Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique

[ISO-abbreviation] Cancer Radiother

[Language] fre

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] France

[Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Progression of prostate cancer despite an extremely low serum level of prostate-specific antigen.

A 61-year-old man who had been diagnosed with prostate cancer 9 years ago and had been treated with pelvic irradiation and intermittent androgen deprivation therapy visited the emergency room because of back pain and weakness in both legs.

The serum prostate-specific antigen was 0.02 ng/ml.

He underwent laminectomy, posterior fixation, and epidural mass excision, and metastatic adenocarcinoma from the prostate was diagnosed.

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[Cites] Int J Clin Oncol. 2007 Dec;12(6):427-32 [18071861.001]

[Cites] Cancer. 2007 Jan 15;109(2):198-204 [17171704.001]

[Cites] J Urol. 1995 Dec;154(6):2128-31 [7500474.001]

[Cites] Urology. 2000 Sep 1;56(3):527-32 [10962338.001]

[Cites] Int J Urol. 2001 Jul;8(7):374-9 [11442659.001]

[Cites] Eur Urol. 2000 Sep;38(3):250-4 [10940696.001]

[Cites] Int Urol Nephrol. 2003;35(2):189-92 [15072491.001]

(PMID = 20495701.001).

[ISSN] 2005-6745

[Journal-full-title] Korean journal of urology

[ISO-abbreviation] Korean J Urol

[Language] eng

[Publication-type] Journal Article

[Publication-country] Korea (South)

[Other-IDs] NLM/ PMC2873892

[Keywords] NOTNLM ; Disease progression / Multiple organ failure / Neoplasm metastasis / Prostate-specific antigen / Prostatic neoplasms

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastasis of prostatic adenocarcinoma to the sphenoid sinus.

The presentation, diagnosis, and management of prostatic adenocarcinoma metastatic to the sphenoid sinus are reviewed.

A 67-year-old man with a history of prostatic adenocarcinoma presented with gradual left visual loss.

Operative biopsy of the lesion was significant for adenocarcinoma of the prostate.

Furthermore, the pathophysiology and potential routes of metastatic disease should be assessed for these primary neoplasms.

Having a high level of suspicion for metastatic disease from specific primary sites will help guide the pathological evaluation.

As in this clinical scenario of a patient with a history of prostatic adenocarcinoma, appropriate analysis would entail sending specimens for immunohistochemical staining, such as prostate-specific antigen and prostate-specific acid phosphatase.

[MeSH-major] Adenocarcinoma / pathology. Paranasal Sinus Neoplasms / secondary. Prostatic Neoplasms / pathology. Sphenoid Sinus / pathology

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(PMID = 17044541.001).

[ISSN] 0003-4894

[Journal-full-title] The Annals of otology, rhinology, and laryngology

[ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic esophageal adenocarcinoma to the prostate presenting with bilateral ureteral obstruction.

Carcinoma metastatic to the prostate occurs rarely and is most commonly associated with malignant bladder neoplasms.

We present the case of a 73-year-old male with a history of gastroesophageal adenocarcinoma and clinically symptomatic benign prostatic hyperplasia who underwent photoselective vaporization of the prostate and presented several months later with gross hematuria, intermittent urinary retention and bilateral ureteral obstruction causing acute renal failure.

After relieving the ureteral obstruction, subsequent transurethral resection of the prostate revealed locally invasive metastatic esophageal adenocarcinoma.

To our knowledge, this is the first reported case of metastatic gastroesophageal carcinoma to the prostate.

[MeSH-major] Adenocarcinoma / secondary. Esophageal Neoplasms / pathology. Prostatic Neoplasms / secondary. Ureteral Obstruction / etiology

[MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness. Prostatic Hyperplasia / diagnosis. Prostatic Hyperplasia / surgery

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(PMID = 20156389.001).

[ISSN] 1195-9479

[Journal-full-title] The Canadian journal of urology

[ISO-abbreviation] Can J Urol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Canada

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Secondary prostatic adenocarcinoma: a cytopathological study of 50 cases.

Positive diagnosis of metastatic prostate adenocarcinoma (PAC) can be made by microscopic examination of the cytologic specimens and immunostaining for prostate-specific antigen (PSA) and prostate acid phosphatase (PAP).

The purpose of this study is to characterize the cytopathology of metastatic PAC as it has not been documented in large series.

Fifty cases of metastatic PAC with cytological specimens consisting of 41 fine-needle aspiration biopsies (FNAB), 6 pleural fluid aspirates, and 3 catheterized urine samples were reviewed and correlated with the surgical specimens and the clinical charts.

In addition to the frequency of high-grade PAC, awareness of the negative immunoreactivity to PSA and PAP, the discrepancy in the histopathological patterns between the primary and secondary tumors, especially the frequent neuroendocrine differentiation, are helpful features for the diagnosis of metastases of prostatic origin.

[MeSH-major] Adenocarcinoma / pathology. Prostatic Neoplasms / pathology

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(PMID = 17230567.001).

[ISSN] 8755-1039

[Journal-full-title] Diagnostic cytopathology

[ISO-abbreviation] Diagn. Cytopathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Metastases in the paranasal sinuses secondary to prostatic adenocarcinoma].

[Transliterated title] Metástasis en senos paranasales secundaria a adenocarcinoma prostático.

OBJECTIVE: To report a new case of exceptional metastases from a prostatic carcinoma.

METHODS: 64-year-old male with nine months history of disseminated prostate cancer, taking hormonal treatment and biphosphonates, who presents with rising PSA, facial dysesthesia and left exophtalmos.

RESULTS: Once the diagnosis was established hormonal maneuvers were performed and chemotherapy with docetaxel was administered achieving at the start of treatment measurable disease stabilization with biochemical remission of PSA levels, followed posteriorly by progression without changes in the metastatic images.

CONCLUSIONS: 1% of the prostatic tumors involve the head in their evolution.

[MeSH-major] Adenocarcinoma / secondary. Paranasal Sinus Neoplasms / secondary. Prostatic Neoplasms / pathology

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(PMID = 18077874.001).

[ISSN] 0004-0614

[Journal-full-title] Archivos españoles de urología

[ISO-abbreviation] Arch. Esp. Urol.

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Spain

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Investigation of pro- and antioxidative systems' changes in blood of patients with prostate tumours.

The aim of the study was to investigate changes in the content of primary, secondary and final LP products and quantitative changes of main antioxidant of plasma - Ceruloplsmin (Cp) in blood of patients with prostate tumors (benign prostate hyperplasia (BPH), benign prostate hyperplasia with PING(3-4) regions and metastatic prostate adenocarcinoma (PCa).

The tendency of diene conjugates reducing has been revealed compared with norm: The control group-->BPH-->benign prostate hyperplasia with PING(3-4)regions-->metastatic PCa.

MDA content was increased in all cases we had studied, but it was significantly increased in benign prostate hyperplasia with PING(3-4) regions and PCa.

Amount of Schiff's bases raised in lipid extracts in all cases of prostate cancer, especially in patients with benign prostate hyperplasia with PING(3-4) regions.

Strong intensification of LP in prostate cancer patients and accumulation of its final products occurs on the background of changes of the antioxidant system.

Both facts express disbalances of the anti- and prooxidative systems of organism in case of prostate gland malignant transformation.

[MeSH-major] Brain Neoplasms / blood. Lipid Peroxidation. Lipid Peroxides / blood. Prostatic Neoplasms / blood

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(PMID = 19430038.001).

[ISSN] 1512-0112

[Journal-full-title] Georgian medical news

[ISO-abbreviation] Georgian Med News

[Language] eng

[Publication-type] Journal Article

[Publication-country] Georgia (Republic)

[Chemical-registry-number] 0 / Antioxidants; 0 / Lipid Peroxides; 4Y8F71G49Q / Malondialdehyde; EC 1.16.3.1 / Ceruloplasmin

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Prostate adenocarcinoma and synchcronous multiple myeloma: a case report].

[Transliterated title] Adenocarcinoma prostático y mieloma múltiple sincrónicos: a propósito de un caso.

PURPOSE: To report a case of synchronous prostatic cancer with multiple myeloma as inusual neoplasm presentation.

To indicate the clinical data that they help to suspect the myeloma presence in the prostate bone metastatic disease.

CASE REPORT: Patient 63 years old diagnosed of prostatic carcinoma with bone metastasis and BAC good responsive, who have clinical deterioration, hypercalcemia and renal insufficiency.

[MeSH-major] Adenocarcinoma / diagnosis. Multiple Myeloma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Prostatic Neoplasms / diagnosis

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(PMID = 17645096.001).

[ISSN] 0210-4806

[Journal-full-title] Actas urologicas españolas

[ISO-abbreviation] Actas Urol Esp

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Spain

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Treatment of painful bony metastases with Samarium 153-EDTMP in prostate carcinoma].

[Transliterated title] Traitement des metastases osseuses douloureuses par le Samarium 153-EDTMP dans le cancer de la prostate.

THE OBJECTIVE of this work is to evaluate a new therapy, the metabolic radiotherapy to the 153Samarium-EDTMP, of recent introduction in Tunisia, in the painful bony metastasis treatment observed at the patients affected of cancer of the prostate.

METHODS: It is about a retrospective survey with a receding of 40 months, achieved through 45 files of patients having benefited all of this new treatment for painful bony metastases in relation with a prostatic adenocarcinoma and collected by three centers of Nuclear Medicine of the capital: the institute Salah Azaiez (state-controlled), the Center CERU (deprives) and the Military hospital (HMPIT).

CONCLUSION: Its precocious introduction in the taken in charge of the metastatic patients, would allow them to benefit better from its efficiency, simplicity and weak toxicity and therefore to enjoy a better quality of life.

[MeSH-major] Analgesics, Non-Narcotic / therapeutic use. Bone Neoplasms / radiotherapy. Organometallic Compounds / therapeutic use. Organophosphorus Compounds / therapeutic use. Pain, Intractable / radiotherapy. Prostatic Neoplasms / pathology

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(PMID = 18064991.001).

[ISSN] 0041-4131

[Journal-full-title] La Tunisie médicale

[ISO-abbreviation] Tunis Med

[Language] fre

[Publication-type] English Abstract; Journal Article; Multicenter Study

[Publication-country] Tunisia

[Chemical-registry-number] 0 / Analgesics, Non-Narcotic; 0 / Organometallic Compounds; 0 / Organophosphorus Compounds; 0 / Radioisotopes; 122575-21-7 / samarium ethylenediaminetetramethylenephosphonate

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Systemic therapy of spontaneous prostate cancer in transgenic mice with oncolytic herpes simplex viruses.

Here we show the efficacy of systemically administered oncolytic viruses for the treatment of spontaneously arising tumors, specifically the use of oncolytic herpes simplex viruses (HSV) administered i.v. to treat spontaneously developing primary and metastatic prostate cancer in the transgenic TRAMP mouse, which recapitulates human prostate cancer progression.

Four administrations of systemically delivered NV1023 virus, an HSV-1/HSV-2 oncolytic recombinant, to TRAMP mice at 12 or 18 weeks of age (presence of prostate adenocarcinoma or metastatic disease, respectively) inhibited primary tumor growth and metastases to lymph nodes.

Expression of interleukin 12 (IL-12) from NV1042 virus, a derivative of NV1023, was additionally effective, significantly reducing the frequency of development of prostate cancer and lung metastases, even when the mice were treated after the onset of metastasis at 18 weeks of age.

NV1042-infected cells, as detected by 5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside staining for Lac Z expressed by the virus, were present in prostate tumors 1 week after the final virus injection and viral DNA was detected at 2 weeks after final virus injection by real-time PCR in primary and metastatic tumors but not in liver or blood.

The efficacy of the IL-12-expressing NV1042 virus in this aggressive prostate cancer model using a clinically relevant treatment paradigm merits its consideration for clinical studies.

[MeSH-major] Adenocarcinoma / therapy. Adenocarcinoma / virology. Oncolytic Virotherapy / methods. Prostatic Neoplasms / therapy. Prostatic Neoplasms / virology. Simplexvirus / physiology

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(PMID = 17909046.001).

[ISSN] 0008-5472

[Journal-full-title] Cancer research

[ISO-abbreviation] Cancer Res.

[Language] eng

[Grant] United States / NCI NIH HHS / CA / 1R01CA102139-0141; United States / NINDS NIH HHS / NS / P30 NS045776

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells.

However, no studies have examined Ron receptor expression or function during prostate tumorigenesis.

In this study we report that Ron is highly expressed in human prostate adenocarcinoma and metastatic lymph nodes when compared with normal prostate or benign prostate hyperplasia.

Furthermore, we show that Ron is overexpressed in PC-3 and DU145 prostate cancer cell lines, and that the levels of angiogenic chemokines produced by prostate cancer cells positively correlate with Ron expression.

Our data show that knockdown of Ron in prostate cancer cells results in significantly less endothelial cell chemotaxis when compared with Ron-expressing cells in vitro as well as in reduced tumor growth and decreased microvessel density after orthotopic transplantation into the prostate in vivo.

In total, our data suggest that the Ron receptor is important in modulating prostate tumor growth by modulating angiogenic chemokine production and subsequent endothelial cell recruitment.

Genetic Alliance. consumer health - Prostate cancer.

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(PMID = 19838218.001).

[ISSN] 1476-5594

[Journal-full-title] Oncogene

[ISO-abbreviation] Oncogene

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R21 CA125370; United States / NCI NIH HHS / CA / R01 CA125379-02; United States / NCI NIH HHS / CA / CA-125370; United States / NCI NIH HHS / CA / R01 CA125379; United States / NCI NIH HHS / CA / CA125379-02; United States / NCI NIH HHS / CA / CA125379-01A2; United States / NCI NIH HHS / CA / R01 CA125379-01A2

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

[Publication-country] England

[Chemical-registry-number] 0 / Antigens, CD31; 0 / Chemokine CXCL1; 0 / Chemokine CXCL5; 0 / Chemokines; 0 / Interleukin-8; 0 / NF-kappa B; EC 2.7.1.- / RON protein; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases

[Other-IDs] NLM/ NIHMS145531; NLM/ PMC2806938