[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 393
1. Shimizu T, Tajiri T, Akimaru K, Arima Y, Yoshida H, Yokomuro S, Mamada Y, Taniai N, Mizuguchi Y, Kawahigashi Y, Naito Z: Combined neuroendocrine cell carcinoma and adenocarcinoma of the gallbladder: report of a case. J Nippon Med Sch; 2006 Apr;73(2):101-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined neuroendocrine cell carcinoma and adenocarcinoma of the gallbladder: report of a case.
  • Abdominal computed tomography confirmed thickening of the gallbladder wall and a 15 x 8 cm mass occupying almost all of the right lobe and medial segment of the liver.
  • With a preoperative diagnosis of malignant gallbladder tumor infiltrating the liver, right hepatic trisegmentectomy was performed.
  • Near this small cell proliferation was a focus of tubular adenocarcinoma that showed a zone of transition from the small cell neuroendocrine pattern.
  • The patient was diagnosed with neuroendocrine cell carcinoma combined with adenocarcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Neuroendocrine / pathology. Gallbladder Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16641536.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


2. Larentzakis A, Theodorou D, Fili K, Manataki A, Bizimi V, Tibishrani M, Katsaragakis S: Sister Mary Joseph's nodule: Three case reports. Cases J; 2008;1(1):182

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the three cases presented, the primary tumor was an adenocarcinona of the sigmoid colon, a carcinoma of the bladder, and an adenocarcinoma of the gallbladder, respectively.
  • CONCLUSION: The differential diagnosis of an umbilical lesion should always include metastatic disease apart from benign lesions and primary neoplasms.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Radiographics. 1998 Mar-Apr;18(2):413-31 [9536487.001]
  • [Cites] Ann Intern Med. 1998 Mar 1;128(5):410 [9490607.001]
  • [Cites] Acta Cytol. 1990 Jul-Aug;34(4):555-8 [2375224.001]
  • [Cites] J Am Acad Dermatol. 1990 Jan;22(1):19-26 [2298962.001]
  • (PMID = 18816407.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2561010
  •  go-up   go-down


3. Sai JK, Suyama M, Kubokawa Y: A case of gallbladder carcinoma associated with pancreatobiliary reflux in the absence of a pancreaticobiliary maljunction: A hint for early diagnosis of gallbladder carcinoma. World J Gastroenterol; 2006 Jul 28;12(28):4593-5
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of gallbladder carcinoma associated with pancreatobiliary reflux in the absence of a pancreaticobiliary maljunction: A hint for early diagnosis of gallbladder carcinoma.
  • A 62-year-old man with progressive thickening of the gallbladder wall visited our outpatient clinic.
  • The biliary amylase level in the common bile duct was 19,900 IU/L and that of the gallbladder was 127,000 IU/L, although endoscopic retrograde cholangiopancreatography revealed no pancreaticobiliary maljunction.
  • Histology demonstrated a moderately differentiated adenocarcinoma of the gallbladder.
  • Pancreatobiliary reflux and associated gallbladder carcinoma were confirmed in the present case, in the absence of a pancreaticobiliary maljunction.
  • Earlier detection of the pancreatobiliary reflux and progressive thickening of the gallbladder wall might have led to an earlier resection of the gallbladder and improved this patient's poor prognosis.
  • [MeSH-major] Adenocarcinoma / complications. Bile Reflux / etiology. Common Bile Duct / physiopathology. Gallbladder Neoplasms / complications. Pancreas / physiopathology
  • [MeSH-minor] Amylases / analysis. Cholangiopancreatography, Endoscopic Retrograde. Gallbladder / enzymology. Gallbladder / pathology. Gallbladder / physiopathology. Humans. Male. Middle Aged. Prognosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Gastroenterology. 1985 Dec;89(6):1258-65 [4054518.001]
  • [Cites] Am J Gastroenterol. 1987 Jan;82(1):20-4 [3799576.001]
  • [Cites] Can J Surg. 1962 Oct;5:461-70 [14012877.001]
  • [Cites] Cancer. 1998 Jul 15;83(2):267-75 [9669809.001]
  • [Cites] Surg Gynecol Obstet. 1958 Mar;106(3):306-20 [13519371.001]
  • [Cites] Am J Gastroenterol. 1996 May;91(5):1007-11 [8633539.001]
  • (PMID = 16874881.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.2.1.- / Amylases
  • [Other-IDs] NLM/ PMC4125656
  •  go-up   go-down


Advertisement
4. Sakellaridis T, Mathioulakis S, Antiochos C: Synchronous early primary adenocarcinoma of both rectum and gallbladder. Report of a case. Int Semin Surg Oncol; 2005 Sep 14;2:19

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous early primary adenocarcinoma of both rectum and gallbladder. Report of a case.
  • BACKGROUND: Synchronous early primary cancers are rare and in addition synchronous adenocarcinoma of both rectum and gallbladder is extremely rare.
  • CASE REPORT: We report an unusual case of synchronous early primary adenocarcinoma of rectum and gallbladder.
  • An endoscopy revealed adenocarcinoma of the lower rectum.
  • The histopathological diagnosis was well to middle differentiate adenocarcinoma of the gallbladder (T2, N0, M0; stage II) and middle differentiate adenocarcinoma of the rectum (T2, N0, M0; stage II).
  • CONCLUSION: For the cases of extracolonic primary cancer associated with colorectal primary carcinoma, Warren and Gates' diagnostic criteria are used.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Chir Ital. 2001 Jan-Feb;53(1):133-9 [11280822.001]
  • [Cites] Asian J Surg. 2003 Jan;26(1):46-8; discussion 49 [12527496.001]
  • [Cites] Jpn J Cancer Res. 1987 Mar;78(3):242-50 [3106280.001]
  • [Cites] Nihon Shokakibyo Gakkai Zasshi. 1997 Jun;94(6):440-4 [9216227.001]
  • [Cites] Gan No Rinsho. 1985 Nov;31(14):1849-53 [4087393.001]
  • [Cites] Srp Arh Celok Lek. 1965 Mar;93(3):323-7 [5861499.001]
  • [Cites] Ann Surg. 1982 Apr;195(4):501-7 [7065754.001]
  • [Cites] Klin Wochenschr. 1988 Nov 1;66(21):1093-6 [3236758.001]
  • (PMID = 16162293.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1236954
  •  go-up   go-down


5. Repiso A, Gómez Rodríguez R, González de Frutos C, de Artaza T, Sánchez Ruano JJ, Pérez Grueso MJ, Martínez Potenciano JL: [Angioma-like liver lesions in patients with chronic liver disease]. Rev Esp Enferm Dig; 2007 May;99(5):259-63
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Lesiones hepáticas sugestivas de angioma en pacientes con hepatopatía crónica.
  • During an average follow-up period of 35 months (6-168 months) we verified that, in two patients, these lesions, initially interpreted as angiomas were in fact malignancies (one hepatocellular carcinoma and one metastatic adenocarcinoma of the gallbladder).

  • Genetic Alliance. consumer health - Liver Disease.
  • Genetic Alliance. consumer health - Angioma.
  • MedlinePlus Health Information. consumer health - Birthmarks.
  • MedlinePlus Health Information. consumer health - Cirrhosis.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17650934.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


6. Garg PK, Khurana N, Hadke NS: Subcutaneous and breast metastasis from asymptomatic gallbladder carcinoma. Hepatobiliary Pancreat Dis Int; 2009 Apr;8(2):209-11
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subcutaneous and breast metastasis from asymptomatic gallbladder carcinoma.
  • BACKGROUND: Though gallbladder carcinoma is associated with early lymphatic and hematogenous spread, the only common extra-abdominal site of metastasis is lung.
  • Gallbladder carcinoma metastasizing to breast and subcutaneous tissue is not known.
  • METHOD: This report describes an interesting and unusual case of asymptomatic gallbladder carcinoma presenting with subcutaneous and breast metastasis.
  • Fine needle aspiration cytology (FNAC) of these nodules revealed metastatic adenocarcinoma.
  • An ultrasound of the abdomen followed by a contrast-enhanced CT scan showed a growth in gallbladder, infiltrating the liver with multiple hepatic metastases.
  • CT-guided FNAC from the growth in the gallbladder revealed adenocarcinoma.
  • She was diagnosed as a case of metastatic adenocarcinoma of the gallbladder and palliative combination chemotherapy with gemcitabine and carboplatin was given.
  • She died within three weeks of diagnosis due to hepatic encephalopathy.
  • CONCLUSIONS: This report highlights an unusual metastasis of gallbladder carcinoma to the breast and subcutaneous tissue presenting as multiple lesions, which has never been reported in the English literature.
  • These were unknown sites of metastasis for carcinoma of the gallbladder.
  • [MeSH-minor] Adult. Female. Gallbladder Neoplasms / pathology. Humans

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19357037.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  •  go-up   go-down


7. Jiao X, Huang J, Wu S, Lv M, Hu Y, Jianfu, Su X, Luo C, Ce B: hOGG1 Ser326Cys polymorphism and susceptibility to gallbladder cancer in a Chinese population. Int J Cancer; 2007 Aug 1;121(3):501-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] hOGG1 Ser326Cys polymorphism and susceptibility to gallbladder cancer in a Chinese population.
  • To determine whether hOGG1 plays a role in the risk for adenocarcinoma of the gallbladder, we tested the association of this polymorphism with gallbladder cancer in a Chinese population-based, case control study of 204 cases and 209 controls.
  • The association between the genetic polymorphism of this gene and risk of the cancer was examined by using a multivariate analysis.
  • We found that the distribution of hOGG1 Ser326Cys genotypes among controls (Ser/Ser, 37.3%; Ser/Cys, 53.6% and Cys/Cys, 9.1%) was significantly different from that among gallbladder cancer cases (Ser/Ser, 43.1%; Ser/Cys, 36.3% and Cys/Cys, 20.6%).
  • Significantly increased risk for gallbladder cancer was both the hOGG1 326Ser/Cys (Odds ratio [OR] = 1.9, 95% confidence interval (CI) = 1.0-3.7) and hOGG1 326Cys/Cys genotypes (OR = 4.5, 95% CI = 1.1-22.4).
  • We observed no statistically significant association between hOGG1 genotype and gallbladder cancer association in gallstone absence.
  • In contrast, a near-significant increase in risk for gallbladder cancer was observed for gallstone presence with the hOGG1 326Ser/Cys genotype (OR = 2.2, CI = 1.4-3.5) whereas a significant increase in association for gallbladder cancer was observed for gallstone presence with the 326Cys/Cys genotype (OR = 6.1, CI = 2.1-27.2).
  • These data corresponded with the fact that a significant trend towards increased association for gallbladder cancer was observed with potentially higher-risk hOGG1 genotypes in gallstone presence(p < 0.001, chi(2) trend test)but not in gallstone absence(p = 0.89, chi(2) trend test).
  • A significant increase in risk for gallbladder cancer was observed for larger gallstone (those with stone diameters 2 cm or greater) with the hOGG1 326Ser/Cys(OR = 1.9, 95% CI = 1.1-2.9) and hOGG1 326Cys/Cys genotypes(OR = 5.9, 95% CI = 1.6-18.0).
  • These data are consistent with the observation that a significant trend towards increased risk for gallbladder cancer was observed with potentially higher-risk hOGG1 genotypes in gallbladder cancer patients with larger gallstone (p < 0.001, chi(2) trend test).
  • However, we observed no statistically significant association between hOGG1 genotype and gallbladder cancer risk in gallbladder cancer patients with smaller gallstone (those with stone diameters 2 cm smaller) (hOGG1 326Ser/Cys:OR = 2.2, 95% CI = 0.8-4.0; hOGG1 326Cys/Cys:OR = 2.9, 95% CI = 0.6-29.4; p = 0.06, chi(2) tread test).
  • These results suggest that hOGG1 Ser326Cys polymorphism is associated with gallbladder cancer risk.
  • [MeSH-major] DNA Glycosylases / genetics. Gallbladder Neoplasms / genetics. Genetic Predisposition to Disease. Polymorphism, Genetic

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • Hazardous Substances Data Bank. CYSTEINE .
  • Hazardous Substances Data Bank. L-SERINE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17417784.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 452VLY9402 / Serine; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / oxoguanine glycosylase 1, human; K848JZ4886 / Cysteine
  •  go-up   go-down


8. Kimura Y, Kashima K, Daa T, Kondo Y, Yada K, Sasaki A, Matsumoto T, Kitano S, Kubo N, Yokoyama S: Biotin-rich intranuclear inclusions in morule-lacking adenocarcinoma of the gallbladder: a new category of "neoplastic/non-morular" lesions. Virchows Arch; 2005 Feb;446(2):194-9
Hazardous Substances Data Bank. BIOTIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biotin-rich intranuclear inclusions in morule-lacking adenocarcinoma of the gallbladder: a new category of "neoplastic/non-morular" lesions.
  • In the present report, we describe two cases of well-differentiated adenocarcinoma of the gallbladder in which biotin-rich intranuclear inclusions were found without morular structures.
  • [MeSH-major] Adenocarcinoma / chemistry. Adenocarcinoma / pathology. Biotin / analysis. Cell Nucleus / chemistry. Gallbladder Neoplasms / chemistry. Gallbladder Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Hum Pathol. 2004 Jul;35(7):869-74 [15257551.001]
  • [Cites] J Histochem Cytochem. 1981 Oct;29(10):1196-204 [7028859.001]
  • [Cites] Pancreas. 2002 Aug;25(2):130-5 [12142734.001]
  • [Cites] Mod Pathol. 1998 Oct;11(10):945-9 [9796720.001]
  • [Cites] Mod Pathol. 1999 Apr;12(4):400-11 [10229505.001]
  • [Cites] Am J Clin Pathol. 2001 Apr;115(4):486-93 [11293895.001]
  • [Cites] Nature. 1999 Apr 1;398(6726):422-6 [10201372.001]
  • [Cites] Am J Surg Pathol. 1999 Mar;23(3):336-41 [10078926.001]
  • [Cites] J Pathol. 2001 May;194(1):59-67 [11329142.001]
  • [Cites] Genes Dev. 1997 Dec 15;11(24):3286-305 [9407023.001]
  • [Cites] Cancer Res. 2001 Jan 1;61(1):19-22 [11196159.001]
  • [Cites] Am J Clin Pathol. 1993 Jan;99(1):13-7 [8380678.001]
  • [Cites] Arch Pathol Lab Med. 1994 Aug;118(8):831-3 [8060235.001]
  • [Cites] Pathol Int. 1995 Aug;45(8):573-9 [7496502.001]
  • [Cites] Mod Pathol. 2003 Nov;16(11):1124-31 [14614052.001]
  • [Cites] Am J Pathol. 2000 Mar;156(3):865-70 [10702403.001]
  • [Cites] Am J Surg Pathol. 1983 Jul;7(5):415-23 [6614307.001]
  • [Cites] J Oral Pathol Med. 2000 Oct;29(9):445-51 [11016687.001]
  • [Cites] Mod Pathol. 2002 Jun;15(6):617-24 [12065775.001]
  • [Cites] Am J Pathol. 1999 Aug;155(2):527-36 [10433945.001]
  • [Cites] Am J Surg Pathol. 1994 Jun;18(6):637-42 [8179079.001]
  • [Cites] J Pathol. 2003 Feb;199(2):185-90 [12533831.001]
  • [Cites] J Biol Chem. 1963 Jan;238:294-6 [14024685.001]
  • (PMID = 15647941.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-6; 0 / Mucins; 0 / Trans-Activators; 0 / beta Catenin; 6SO6U10H04 / Biotin; EC 4.1.1.41 / Methylmalonyl-CoA Decarboxylase; EC 6.4.1.1 / Pyruvate Carboxylase
  •  go-up   go-down


9. Tokunaga T, Arakawa H, Kuwashima Y: A case of lepidic pulmonary metastasis from adenocarcinoma of the gallbladder mimicking acute interstitial pneumonia. Clin Radiol; 2005 Nov;60(11):1213-5
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of lepidic pulmonary metastasis from adenocarcinoma of the gallbladder mimicking acute interstitial pneumonia.
  • [MeSH-major] Adenocarcinoma / secondary. Gallbladder Neoplasms / pathology. Lung Diseases, Interstitial / diagnosis. Lung Neoplasms / secondary
  • [MeSH-minor] Acute Disease. Aged. Diagnosis, Differential. Fatal Outcome. Female. Humans. Tomography, X-Ray Computed

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • MedlinePlus Health Information. consumer health - Interstitial Lung Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16223618.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


10. Charalampopoulos A, Lazaris A, Misiakos E, Liakakos S, Macheras A, Peschos D, Batistatou A, Fotiadis K, Charalabopoulos K: Acute septic cholelithiasic cholecystitis and adenocarcinoma of the gallbladder; an interesting association. Acta Gastroenterol Belg; 2007 Jul-Sep;70(3):267-70
MedlinePlus Health Information. consumer health - Sepsis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute septic cholelithiasic cholecystitis and adenocarcinoma of the gallbladder; an interesting association.
  • BACKGROUND AND STUDY AIMS: Primary carcinoma of the gallbladder may present as acute lithiasic cholecystitis that leads to severe septic complications.
  • The correlation between severe sepsis of the gallbladder and primary carcinoma is unclear.
  • The goal of the present study is to examine the relation between severe septic complications of lithiasic cholecystitis and primary carcinoma of the gallbladder.
  • PATIENTS AND METHODS: A group of 72 patients (22 males, 50 females, age range: 45-99, mean age: 68.6 years), with severe septic cholelithiasic cholecystitis was treated with emergency surgery after failure of conservative treatment, and patients found with primary carcinoma of the gallbladder were registered.
  • RESULTS: During urgent surgery for severe septic lithiasic cholecystitis, 12 patients (12/72, 16.6%) were found with gallbladder carcinoma.
  • CONCLUSIONS: Severe septic complications in elderly patients with a long-standing history of gallbladder stones may co-exist with primary carcinoma of the gallbladder.
  • The percentage of a gallbladder carcinoma detected in septic patients reaches up to 16.6%.
  • The possibility of a carcinoma hidden in the gallbladder must be in mind during surgery.
  • [MeSH-major] Adenocarcinoma / complications. Cholecystitis, Acute / complications. Cholecystolithiasis / complications. Gallbladder Neoplasms / complications. Sepsis / complications

  • Genetic Alliance. consumer health - Cholecystitis.
  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18074735.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Belgium
  •  go-up   go-down


11. Triolo O, Antico F, Mancuso A, Salimbeni V, Nicotina PA: Postmenopausal bleeding and vaginal nodules as the first presenting sign of adenocarcinoma of the gallbladder. Eur J Gynaecol Oncol; 2005;26(5):543-4
MedlinePlus Health Information. consumer health - Vaginal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postmenopausal bleeding and vaginal nodules as the first presenting sign of adenocarcinoma of the gallbladder.
  • On biopsy, light microscopy suggested that the lesions might be metastatic foci from an extragenital cancer, with a prevalent tubular growth pattern.
  • Subsequently, high serum levels of such tumor marker were also found, and an extragenital cancer was suspected of pancreatic or biliary origin.
  • A mass in the gallbladder fossa was then detected by computed tomography and a primary gallbladder adenocarcinoma was confirmed on ultrasound-guided biopsy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Gallbladder Neoplasms / diagnosis. Uterine Neoplasms / diagnosis. Vaginal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Fatal Outcome. Female. Humans. Neoplasm Metastasis. Postmenopause. Uterine Hemorrhage / etiology

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • MedlinePlus Health Information. consumer health - Uterine Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16285575.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


12. Sato K, Imai T, Shirota Y, Ueda Y, Katsuda S: Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. Pathol Res Pract; 2010 Jun 15;206(6):397-400
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder.
  • There are six previous reports on LCNEC in the gallbladder, comprising three cases combined with another tumor and three pure LCNECs.
  • We describe a tumor combined with LCNEC and adenocarcinoma elements arising in the gallbladder and give a review of the literature.
  • A 68-year-old woman was diagnosed as having gallbladder wall thickening and a hepatic mass.
  • The surgically resected tumor had a dumbbell shape with gallbladder and liver elements.
  • Histological examination revealed LCNEC in the liver and a deep infiltrative portion of the gallbladder, as well as a well-differentiated tubular adenocarcinoma in the mucosa of the gallbladder.
  • The results suggest a close relationship between LCNEC and adenocarcinoma, and support the theory that these elements originate from common cancer stem cells.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Gallbladder Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19945229.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Chromogranin A; 0 / Synaptophysin
  • [Number-of-references] 15
  •  go-up   go-down


13. D'Angelica M, Dalal KM, DeMatteo RP, Fong Y, Blumgart LH, Jarnagin WR: Analysis of the extent of resection for adenocarcinoma of the gallbladder. Ann Surg Oncol; 2009 Apr;16(4):806-16
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of the extent of resection for adenocarcinoma of the gallbladder.
  • Gallbladder cancer has historically been considered an incurable malignancy; although, extended resection has been associated with cure in selected patients.
  • The objective of this study was to analyze the impact of the extent of resection for gallbladder adenocarcinoma on disease-specific survival (DSS) and perioperative morbidity.
  • Analysis of a prospective hepatobiliary surgery database identified patients undergoing surgical resection for gallbladder adenocarcinoma from 1990 to 2002.
  • We conclude that tumor biology and stage, rather than extent of resection, predict outcome after resection for gallbladder cancer.
  • [MeSH-major] Adenocarcinoma / surgery. Bile Duct Neoplasms / surgery. Gallbladder Neoplasms / surgery. Liver Neoplasms / surgery

  • MedlinePlus Health Information. consumer health - Bile Duct Cancer.
  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Ann Surg Oncol. 2009 Aug;16(8):2084-5 [19506960.001]
  • [CommentIn] Ann Surg Oncol. 2009 Apr;16(4):787-8 [19165545.001]
  • (PMID = 18985272.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


14. Gakiopoulou H, Givalos N, Liapis G, Agrogiannis G, Patsouris E, Delladetsima I: Hepatoid adenocarcinoma of the gallbladder. Dig Dis Sci; 2007 Dec;52(12):3358-62
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatoid adenocarcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Aged. Cholecystectomy / methods. Diagnosis, Differential. Female. Humans. Liver Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Clin Pathol. 2004 Nov;122(5):721-7 [15491968.001]
  • [Cites] Hepatology. 1999 Jan;29(1):57-61 [9862850.001]
  • [Cites] Cancer. 1985 Aug 15;56(4):840-8 [2410093.001]
  • [Cites] Pathology. 2005 Jun;37(3):211-5 [16175893.001]
  • [Cites] Histopathology. 2005 Dec;47(6):649-51 [16324210.001]
  • [Cites] Am J Surg Pathol. 1995 Jan;19(1):91-9 [7802141.001]
  • [Cites] Mayo Clin Proc. 1997 Dec;72(12):1154-60 [9413299.001]
  • [Cites] Med Electron Microsc. 2000;33(2):57-63 [11810459.001]
  • [Cites] Dig Dis Sci. 1993 Mar;38(3):561-4 [7680305.001]
  • [Cites] Int J Cancer. 1994 Aug 1;58(3):430-5 [7519587.001]
  • [Cites] Am J Surg Pathol. 2003 Oct;27(10):1302-12 [14508391.001]
  • [Cites] J Hepatobiliary Pancreat Surg. 2000;7(2):226-30 [10982619.001]
  • [Cites] Am J Clin Pathol. 2001 May;115(5):689-94 [11345832.001]
  • [Cites] Pathol Int. 2004 Jan;54(1):52-6 [14674996.001]
  • (PMID = 17510803.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


15. Sakamoto K, Kimura N, Tokumura H, Ogasawara T, Moriya T, Sasano H: Hepatoid adenocarcinoma of the gallbladder. Histopathology; 2005 Dec;47(6):649-51
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatoid adenocarcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16324210.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / alpha-Fetoproteins; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
  •  go-up   go-down


16. de la Parra-Márquez ML, Martínez-Garza H, Sánchez-Antúnez D, Cabañas-López A, Ramírez-Garza M, González-Quintanilla A: [Adenocarcinoma of the gallbladder as a histopathological finding after cholecystectomy]. Cir Cir; 2005 Mar-Apr;73(2):97-100
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenocarcinoma of the gallbladder as a histopathological finding after cholecystectomy].
  • [Transliterated title] Adenocarcinoma de vesícula biliar como hallazgo histopatológico posterior a colecistecomía.
  • OBJECTIVE: We wanted to determine the incidence in our population of gallbladder adenocarcinoma based on a histopathologic study done after cholecystectomy in patients with a diagnosis of gallstones.
  • Finally, we calculated the incidence of malignant neoplasias of gallbladder in our hospital.
  • RESULTS: The most common histopathologic finding was cholesterolosis (incidence: 26%), followed by xanthogranulomatous gallbladder (incidence: 0.94%).
  • The incidence of gallbladder cancer was 0.54% (25 cases), the most common type being adenocarcinoma (incidence: 0.48%).
  • CONCLUSIONS: The incidence of gallbladder cancer in our hospital is among the lowest limits compared with the literature worldwide.
  • [MeSH-major] Adenocarcinoma / epidemiology. Gallbladder Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cholecystectomy. Cholecystectomy, Laparoscopic. Female. Gallbladder / pathology. Gallstones / surgery. Humans. Incidence. Male. Middle Aged. Retrospective Studies

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15910701.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Mexico
  •  go-up   go-down


17. Chicos SC, Beznea A, Chebac GR, Ceauşu M, Ceauşu M: [The Krukenberg tumor caused by an adenocarcinoma of the gallbladder]. Chirurgia (Bucur); 2007 Jul-Aug;102(4):481-5
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The Krukenberg tumor caused by an adenocarcinoma of the gallbladder].
  • This work presents the case of a 62 year-old woman's Krukenberg tumor caused by an adenocarcinoma of the gallbladder.
  • This was the presumptive diagnosis that was confirmed during the operation.
  • The characteristic feature of this case consists of the rarity of the Krukenberg tumors caused by a cancer of the gallbladder, the paraneoplastic pleurisy and the presence of the cells with "a ring with a seal" in the pleural liquid and in the ascites liquid.
  • The paraclinical investigations (echography, computerised tomography) were not able to specify the diagnosis before the operation.
  • [MeSH-major] Adenocarcinoma / secondary. Gallbladder Neoplasms / pathology. Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17966948.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
  •  go-up   go-down


18. Costello MR, Meropol NJ, Denlinger CS, Engstrom PF, Wright JJ, Li T, Mclaughlin S, Beard M, Cimildoro R, Cohen SJ: A phase II trial of the proteasome inhibitor bortezomib in patients with recurrent or metastatic adenocarcinoma of the bile duct or gallbladder (NCI #6135). J Clin Oncol; 2009 May 20;27(15_suppl):e15605

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A phase II trial of the proteasome inhibitor bortezomib in patients with recurrent or metastatic adenocarcinoma of the bile duct or gallbladder (NCI #6135).
  • : e15605 Background: There is currently no standard therapy for recurrent or metastatic cancers of the bile duct or gallbladder and available chemotherapy is of uncertain benefit.
  • METHODS: Patients with measurable metastatic or unresectable adenocarcinoma of the bile duct or gallbladder who had received up to 2 prior chemotherapy regimens were eligible.
  • RESULTS: 20 patients were enrolled: 11M/9F, PS 0/1 (7/13), 6 gallbladder /14 bile duct.
  • CONCLUSIONS: Bortezomib is not an active agent in the treatment of metastatic gallbladder or biliary tract cancer.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 27962683.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


19. Kim K, Jang GD, Lim HS, Kim HS, Shin JG, Lee JL, Ryu MH, Chang HM, Kang YK, Kim TW: Pharmacokinetic and pharmacogenetic study of S-1 in Korean patients with metastatic biliary cancer. J Clin Oncol; 2009 May 20;27(15_suppl):2505

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pharmacokinetic and pharmacogenetic study of S-1 in Korean patients with metastatic biliary cancer.
  • We evaluated associations of genetic variants of CYP2A6 with PK/PD of S-1 when combined with oxaliplatin in metastatic biliary cancer.
  • METHODS: This is a prospective study of patients with histologically confirmed metastatic adenocarcinoma of the biliary tract.
  • Thirty patients (61%) had intrahepatic cholangiocarcinoma and 10 (20%) gallbladder cancer.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 27961956.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


20. Yoshimitsu K, Irie H, Aibe H, Tajima T, Nishie A, Asayama Y, Matake K, Yamaguchi K, Matsuura S, Honda H: Well-differentiated adenocarcinoma of the gallbladder with intratumoral cystic components due to abundant mucin production: a mimicker of adenomyomatosis. Eur Radiol; 2005 Feb;15(2):229-33
MedlinePlus Health Information. consumer health - MRI Scans.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Well-differentiated adenocarcinoma of the gallbladder with intratumoral cystic components due to abundant mucin production: a mimicker of adenomyomatosis.
  • The prevalence and etiology of the cystic components within gallbladder carcinomas as seen on MR images were evaluated.
  • A retrospective review of MR images was performed for 35 proven gallbladder carcinomas in search of radiologically detectable intratumoral cystic components.
  • Three cases out of 35 proven gallbladder carcinomas were found to have intratumoral cystic components.
  • They were all well-differentiated adenocarcinomas, and the cystic components consisted of dilated neoplastic glands filled with abundant mucin pool.
  • Although rare, radiologists need to be aware that well-differentiated gallbladder carcinoma with mucin production can have cystic components, which may mimic adenomyomatosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Gallbladder Neoplasms / pathology. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adenomyoma / pathology. Adult. Aged. Diagnosis, Differential. Female. Humans. Japan / epidemiology. Male. Middle Aged. Prevalence. Retrospective Studies. Statistics, Nonparametric

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Radiology. 2003 Apr;227(1):80-8 [12601186.001]
  • [Cites] Eur Radiol. 2003 Sep;13(9):2233-5 [12928971.001]
  • [Cites] Am J Roentgenol Radium Ther Nucl Med. 1960 May;83:795-827 [14408274.001]
  • [Cites] Eur Radiol. 2004 Mar;14 (3):440-6 [12904879.001]
  • [Cites] Abdom Imaging. 1998 Jan-Feb;23 (1):73-7 [9437067.001]
  • [Cites] Acta Radiol Diagn (Stockh). 1985 Nov-Dec;26(6):689-92 [3909749.001]
  • [Cites] Br J Radiol. 1961 Feb;34:101-12 [13694841.001]
  • [Cites] Br J Radiol. 1986 Jan;59(697 ):29-34 [3081071.001]
  • [Cites] J Comput Assist Tomogr. 2001 Nov-Dec;25(6):843-50 [11711793.001]
  • [Cites] AJR Am J Roentgenol. 1999 Jun;172(6):1535-40 [10350285.001]
  • [Cites] Hepatogastroenterology. 1998 Jul-Aug;45(22):927-9 [9755982.001]
  • [Cites] Radiology. 1983 Mar;146(3):747-52 [6402802.001]
  • [Cites] Clin Radiol. 1988 Jul;39(4):402-6 [3052997.001]
  • (PMID = 15662477.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


21. van den Bos IC, Hussain SM, Dwarkasing RS, Stoop H, Zondervan PE, Krestin GP, de Man RA: Hepatoid adenocarcinoma of the gallbladder: a mimicker of hepatocellular carcinoma. Br J Radiol; 2007 Dec;80(960):e317-20
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatoid adenocarcinoma of the gallbladder: a mimicker of hepatocellular carcinoma.
  • We present a case of a large gallbladder tumour in a patient with no known liver disease and elevated alpha-fetoprotein (AFP), in whom a differential diagnosis from hepatocellular carcinoma (HCC) in a non-cirrhotic liver was particularly difficult given the combination of the size of the tumour, solitary nature, elevated AFP and striking resemblance with HCC at histology.
  • In presenting this patient, we would like to emphasise the role of MRI as a problem-solving tool for analysis of rare tumours of non-hepatocellular origin, including hepatoid adenocarcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Hepatocellular / diagnosis. Gallbladder Neoplasms / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18065642.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


22. Suh B: Resolution of persistent Pediococcus bacteremia with daptomycin treatment: case report and review of the literature. Diagn Microbiol Infect Dis; 2010 Jan;66(1):111-5
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case of bacteremia caused by Pediococcus acidilactici occurring in a patient with metastatic adenocarcinoma of the gallbladder is described.

  • MedlinePlus Health Information. consumer health - Antibiotics.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [ErratumIn] Diagn Microbiol Infect Dis.2010 Apr;66(4):460
  • (PMID = 19081696.001).
  • [ISSN] 1879-0070
  • [Journal-full-title] Diagnostic microbiology and infectious disease
  • [ISO-abbreviation] Diagn. Microbiol. Infect. Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; NWQ5N31VKK / Daptomycin
  •  go-up   go-down


23. Ozan H, Ozerkan K, Aker S, Bülbül M: A case with three primary tumors of the ovary, endometrium and gallbladder. Eur J Gynaecol Oncol; 2008;29(5):551-3
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case with three primary tumors of the ovary, endometrium and gallbladder.
  • She further underwent cholecystectomy for a perioperative incidental suspicious nodule on the serosal surface of the gallbladder.
  • Histopathology revealed a uterine endometrioid adenocarcinoma, a mucinous adenocarcinoma of the gallbladder, and an ovarian endometrioid carcinoma with a clear cell component.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Endometrioid / pathology. Endometrial Neoplasms / pathology. Gallbladder Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19051835.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


24. Tayo JR, Al-Abdulkarim H, Al-Rayess M: Brain metastasis as an initial manifestation of a gallbladder carcinoma. Neurosciences (Riyadh); 2005 Jul;10(3):235-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brain metastasis as an initial manifestation of a gallbladder carcinoma.
  • Though autopsy studies demonstrated 5% metastasis to the brain, clinical presentation of a central nervous system metastasis from gallbladder cancer is rare.
  • We report a case of a 72-year-old woman who initially presented with a solitary brain metastasis from an adenocarcinoma of the gallbladder, which was diagnosed pre-operatively as glioblastoma multiforme.
  • We emphasize the importance of including metastasis in the differential diagnosis of single intracranial tumor for proper planning of patient management.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 22473267.001).
  • [ISSN] 1319-6138
  • [Journal-full-title] Neurosciences (Riyadh, Saudi Arabia)
  • [ISO-abbreviation] Neurosciences (Riyadh)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  •  go-up   go-down


25. Kocyigit P, Akay BN, Arica E, Anadolu RY, Erdem C: Post-renal transplantation Leser-Trélat sign associated with carcinoma of the gallbladder: a rare association. Scand J Gastroenterol; 2007 Jun;42(6):779-81
MedlinePlus Health Information. consumer health - Kidney Transplantation.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Post-renal transplantation Leser-Trélat sign associated with carcinoma of the gallbladder: a rare association.
  • In the literature, there is only one case of gallbladder carcinoma associated with the Leser-Trélat sign.
  • The search for an underlying malignancy showed the presence of an adenocarcinoma of the gallbladder which had metastasized to the liver.
  • [MeSH-major] Gallbladder Neoplasms / pathology. Keratosis, Seborrheic / pathology. Kidney Transplantation

  • Genetic Alliance. consumer health - Transplantation.
  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17506003.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  •  go-up   go-down


26. Oguzkurt L, Ozkan U, Gumus B: Percutaneous transhepatic cutting balloon papillotomy for removal of common bile duct stones. Cardiovasc Intervent Radiol; 2009 Sep;32(5):1117-9
Hazardous Substances Data Bank. SODIUM CHLORIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report the case of a 66-year-old female who presented with jaundice secondary to recurrent adenocarcinoma of the gallbladder and several common bile duct stones.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19093146.001).
  • [ISSN] 1432-086X
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 451W47IQ8X / Sodium Chloride
  •  go-up   go-down


27. Czito BG, Hurwitz HI, Clough RW, Tyler DS, Morse MA, Clary BM, Pappas TN, Fernando NH, Willett CG: Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience. Int J Radiat Oncol Biol Phys; 2005 Jul 15;62(4):1030-4
Hazardous Substances Data Bank. FLUOROURACIL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience.
  • PURPOSE: Primary adenocarcinoma of the gallbladder is a rare malignancy.
  • METHODS AND MATERIALS: Twenty-two patients with primary and nonmetastatic gallbladder cancer were treated with radiation therapy after surgical resection.
  • CONCLUSION: Our series suggests that an approach of radical resection followed by external-beam radiation therapy with radiosensitizing 5-FU in patients with locally advanced, nonmetastatic carcinoma of the gallbladder may improve survival.
  • This regimen should be considered in patients with resectable gallbladder carcinoma.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Fluorouracil / therapeutic use. Gallbladder Neoplasms / drug therapy. Gallbladder Neoplasms / radiotherapy

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15990005.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
  •  go-up   go-down


28. Itoh T, Fuji N, Taniguchi H, Yasukawa S, Yasuda H, Wakabayashi N, Watanabe T, Kosuga T, Kashimoto K, Yanagisawa A, Naito K: Double cancer of the cystic duct and gallbladder associated with low junction of the cystic duct. J Hepatobiliary Pancreat Surg; 2008;15(3):338-43
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Double cancer of the cystic duct and gallbladder associated with low junction of the cystic duct.
  • We report a case of double cancer of the cystic duct and gallbladder associated with low junction of the cystic duct.
  • Endoscopic retrograde cholangiography showed a stenotic lesion in the lower common bile duct and no visualization of the cystic duct or gallbladder.
  • A diagnosis of cancer arising from the cystic duct that entered the lower part of the common hepatic duct was made by intraductal ultrasonography, which showed an intraluminal protruding lesion in the cystic duct.
  • Isolated gallbladder cancer was also diagnosed, by abdominal computed tomography.
  • Histological examination revealed moderately differentiated adenocarcinoma of the cystic duct and well-differentiated adenocarcinoma of the gallbladder.
  • Double cancer of the cystic duct and gallbladder is extremely rare, and this case also suggests a relationship between a low junction of the cystic duct and neoplasm in the biliary tract.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / pathology. Cystic Duct. Gallbladder Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

  • MedlinePlus Health Information. consumer health - Bile Duct Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18535776.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
  •  go-up   go-down


29. von Meyenfeldt EM, Mantel SF, Gouma DJ, van Gulik TM: [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours]. Ned Tijdschr Geneeskd; 2007 May 12;151(19):1049-54
MedlinePlus Health Information. consumer health - Gallbladder Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumors in the gallbladder: a possible differentiation between malignant and benign tumours].
  • [Transliterated title] Tumoren in de galblaas; een moeilijke differentiatie tussen maligniteit en goedaardige tumor.
  • In a 59-year-old woman with pain in the right upper abdomen, echography and CT-scan revealed adenomatosis of the gallbladder.
  • In a 46-year-old man with fever and weight loss, echography revealed two polyps in the gallbladder.
  • In a 63-year-old man with systemic symptoms, a biopsy of the echographically diagnosed tumour of the gallbladder revealed that he had actually had cholecystitis.
  • Following cholecystectomy, an adenocarcinoma of the gallbladder was found.
  • Patients with a tumour in the gallbladder are often diagnosed with gallbladder cancer, which has a poor prognosis.
  • [MeSH-major] Cholecystectomy / methods. Gallbladder Diseases / diagnosis. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Polyps / diagnosis. Polyps / surgery. Tomography, X-Ray Computed / methods. Ultrasonography / methods

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Ned Tijdschr Geneeskd. 2007 Jul 21;151(29):1653; author reply 1653 [17727189.001]
  • [CommentIn] Ned Tijdschr Geneeskd. 2007 Jul 21;151(29):1652-3; author reply 1653 [17729454.001]
  • [CommentOn] Ned Tijdschr Geneeskd. 2007 May 12;151(19):1083-6 [17552418.001]
  • (PMID = 17552411.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; Comment; English Abstract; Journal Article
  • [Publication-country] Netherlands
  •  go-up   go-down


30. Kitajima K, Kobayashi S, Shiba H, Uwagawa T, Ishida Y, Aiba K, Kawakami M, Yanaga K: Successful treatment of advanced gallbladder cancer with an anticancer drug S-1: assessment based on intratumoral gene. Int J Clin Oncol; 2008 Dec;13(6):545-51
Hazardous Substances Data Bank. FLUOROURACIL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment of advanced gallbladder cancer with an anticancer drug S-1: assessment based on intratumoral gene.
  • While surgical resection is the most effective treatment for gallbladder cancer, most of these cancers are not resectable at the time of diagnosis, and therefore, chemotherapy serves as the primary therapy in many cases.
  • However, to date, there is no standard chemotherapy for this cancer.
  • We report a case of advanced gallbladder cancer for which the anticancer drug S-1 was effective.
  • On workup, all abdominal images revealed the presence of advanced gallbladder cancer that had invaded the liver.
  • Because the gallbladder formed a relatively hard and swollen mass involving the omentum, as revealed during exploration, the surgical resection of the gallbladder was not possible at that time, and only hysterectomy and bilateral salpingo-oophorectomy were performed.
  • Pathologically, the tumor was diagnosed as an adenocarcinoma of the gallbladder, and no evidence of liver invasion was found.
  • Intratumoral gene expression analysis of the resected gallbladder revealed significantly elevated DPD expression.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Dihydrouracil Dehydrogenase (NADP) / genetics. Gallbladder Neoplasms / drug therapy. Gallbladder Neoplasms / genetics. Oxonic Acid / therapeutic use. Tegafur / therapeutic use

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Jpn J Cancer Res. 1987 Jul;78(7):748-55 [3114201.001]
  • [Cites] Cancer Treat Rep. 1987 Mar;71(3):261-5 [3815393.001]
  • [Cites] J Clin Oncol. 1994 Oct;12(10):2035-42 [7931471.001]
  • [Cites] Gan To Kagaku Ryoho. 2004 Oct;31(10):1561-3 [15508451.001]
  • [Cites] Invest New Drugs. 2001;19(1):41-59 [11291832.001]
  • [Cites] Clin Cancer Res. 2000 Apr;6(4):1322-7 [10778957.001]
  • [Cites] Cancer Treat Rev. 2002 Feb;28(1):27-47 [12027413.001]
  • [Cites] Prostate Cancer Prostatic Dis. 2005;8(3):260-5 [15999119.001]
  • [Cites] Int J Cancer. 2004 Dec 20;112(6):967-73 [15316940.001]
  • [Cites] Lancet Oncol. 2003 Mar;4(3):167-76 [12623362.001]
  • [Cites] World J Surg. 2004 Jan;28(1):47-9 [14639492.001]
  • [Cites] Cancer. 2000 Aug 15;89(4):757-62 [10951337.001]
  • [Cites] Br J Cancer. 2004 Nov 15;91(10):1769-74 [15505626.001]
  • [Cites] Proc Natl Acad Sci U S A. 1986 Dec;83(23):8923-5 [3466165.001]
  • [Cites] Int J Mol Med. 2003 Dec;12(6):839-44 [14612954.001]
  • [Cites] Curr Treat Options Gastroenterol. 2006 Apr;9(2):95-106 [16539870.001]
  • [Cites] Clin Cancer Res. 2006 Jan 1;12(1):29-33 [16397020.001]
  • [Cites] Cancer Res. 1995 Apr 1;55(7):1407-12 [7882343.001]
  • [Cites] Gan To Kagaku Ryoho. 2003 Jul;30(7):1013-6 [12894721.001]
  • [Cites] Oncol Rep. 2004 May;11(5):973-9 [15069534.001]
  • [Cites] J Clin Oncol. 1994 Dec;12(12):2640-7 [7989939.001]
  • [Cites] Pharmacol Ther. 1990;48(2):189-222 [2293239.001]
  • (PMID = 19093184.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; EC 1.3.1.2 / Dihydrouracil Dehydrogenase (NADP); U3P01618RT / Fluorouracil
  •  go-up   go-down


31. Inagaki M, Goto J, Suzuki S, Ishizaki A, Tanno S, Kohgo Y, Tokusashi Y, Miyokawa N, Kasai S: Gallbladder carcinoma associated with occult pancreatobiliary reflux in the absence of pancreaticobiliary maljunction. J Hepatobiliary Pancreat Surg; 2007;14(5):529-33
MedlinePlus Health Information. consumer health - Pancreatic Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gallbladder carcinoma associated with occult pancreatobiliary reflux in the absence of pancreaticobiliary maljunction.
  • We herein report a case of gallbladder carcinoma associated with occult pancreatobiliary reflux (PR) in the absence of pancreatobiliary maljunction.
  • A 67-year-old woman was referred to our hospital for the evaluation and treatment of a gallbladder tumor.
  • Ultrasonography and computed tomography showed a nodular lesion in the fundus of the gallbladder, indicating the possibility of a gallbladder carcinoma.
  • An open cholecystectomy and partial resection of the liver bed of the gallbladder with regional lymphadenectomy was performed.
  • Biliary amylase and lipase levels sampled in the gallbladder were 2604 IU/l and 775 IU/l, respectively.
  • The histopathological findings of the resected specimen showed a well-differentiated adenocarcinoma of the gallbladder with invasion to the muscle layer and no metastasis of the resected lymph nodes.
  • A high index of nuclear staining for MIB-I in the cancer cells (about 10%) was exhibited, and a few cells in the normal epithelium also stained positive.
  • [MeSH-major] Bile Reflux / complications. Carcinoma / complications. Gallbladder Neoplasms / complications. Pancreas / abnormalities. Pancreatic Diseases / complications

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17909727.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


32. Knutsen A, Sielaff TD, Greeno E, Tuttle TM: Staged laparoscopic infusion of hyperthermic intraperitoneal chemotherapy after cytoreductive surgery. J Gastrointest Surg; 2006 Jul-Aug;10(7):1038-43
Hazardous Substances Data Bank. MITOMYCIN C .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary malignancies included adenocarcinoma of the ileum (one patient), adenocarcinoma of the appendix (three patients), and adenocarcinoma of the gallbladder (one patient).
  • Quality of life was measured with the Functional Assessment of Cancer Therapy-Colon Subscale (FACT-C).
  • [MeSH-major] Adenocarcinoma / drug therapy. Antibiotics, Antineoplastic / administration & dosage. Hyperthermia, Induced / methods. Infusions, Parenteral / methods. Peritoneal Neoplasms / drug therapy

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Ann Surg Oncol. 1999 Dec;6(8):727-31 [10622499.001]
  • [Cites] J Clin Oncol. 2003 Dec 15;21(24):4560-7 [14673042.001]
  • [Cites] J Am Coll Surg. 2001 Aug;193(2):225-9 [11491455.001]
  • [Cites] Arch Surg. 2004 Jan;139(1):20-6 [14718269.001]
  • [Cites] J Clin Oncol. 2004 Aug 15;22(16):3284-92 [15310771.001]
  • [Cites] Ann Surg Oncol. 1999 Dec;6(8):790-6 [10622509.001]
  • [Cites] Eur J Surg Oncol. 2001 Feb;27(1):65-73 [11237495.001]
  • [Cites] J Clin Oncol. 2003 Oct 15;21(20):3737-43 [14551293.001]
  • [Cites] J Clin Oncol. 1993 Mar;11(3):570-9 [8445433.001]
  • [Cites] Cancer. 2000 Jan 15;88(2):358-63 [10640968.001]
  • [Cites] Ann Surg Oncol. 2003 Mar;10(2):155-62 [12620911.001]
  • [Cites] Ann Surg Oncol. 2004 Feb;11(2):178-86 [14761921.001]
  • (PMID = 16843875.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
  •  go-up   go-down


33. Choi HJ, Yun SS, Kim HJ, Choi JH: Expression of p16 protein in gallbladder carcinoma and its precancerous conditions. Hepatogastroenterology; 2010 Jan-Feb;57(97):18-21
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of p16 protein in gallbladder carcinoma and its precancerous conditions.
  • BACKGROUND/AIMS: Adenocarcinoma of the gallbladder is a highly malignant neoplasm. p16 is a tumor suppressor gene protein, which is a cyclin-dependent kinase inhibitor that regulates the G1-S phase of the cell cycle.
  • The purpose of the present study was to investigate the expression of p16 in gallbladder carcinoma and its precancerous conditions and to examine the relationship between p16 expression and clinicopathological parameters.
  • METHODOLOGY: Formalin-fixed, paraffin-embedded tissue sections from 20 cases of normal gallbladder, 20 cases of chronic cholecystitis, 20 cases of gallbladder adenoma, 20 cases of dysplasia, and 58 cases of adenocarcinoma were examined.
  • RESULTS: In normal gallbladder, no expression of p16 was found.
  • In gallbladder adenomas, expression of p16 was found in 20% (4/20).
  • In gallbladder adenocarcinomas, p16 expression was found in 27.6% (16/58).
  • CONCLUSIONS: P16 protein overexpression is an early and relatively common event in carcinogenesis of gallbladder carcinoma.
  • Expression of p16 may be an ancillary diagnostic marker of gallbladder carcinoma and its precancerous conditions.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Cholecystitis / metabolism. Gallbladder Neoplasms / metabolism. Neoplasm Proteins / metabolism. Precancerous Conditions / metabolism

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20422865.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Neoplasm Proteins; 0 / P16 protein, human
  •  go-up   go-down


34. Rifatbegović Z, Mesić D, Ljuca F, Zildzić M, Morankić M: [Incidence and surgical treatment of cancer in gallbladder]. Med Arh; 2007;61(1):30-3
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Incidence and surgical treatment of cancer in gallbladder].
  • The gallbladder cancer is the most common primary cancer of the hepatobiliary system, and ranks fifth of the cancers of the gastrointestinal system.
  • GOAL: Show the incidence, clinical state, and suplement the diagnostic procedure of the patients with the risk factors for gallbladder cancer.
  • Find proper surgical treatment in every stage of the disease according to Nevin-Moran system and the hystological type of the cancer.
  • We established the incidence of gallbladder cancer and we tried to discover the common characteristics of this group of patients.
  • We analized the histological type of the cancer, and the stage of the disease in correlation with clinical presentation, results of the surgical treatment , and the survival and the quality of life.
  • RESULTS: In three years we performed 2553 cholecystectomies, and in 1,7 % of patients -43 patient we discovered the cancer of gallbladder.
  • The mean age of the patients with gallbladder cancer is 65 years (55 - 82 years).
  • In 5 (11,6 %) patients cancer is discovered preoperatively.
  • In 38 (88,4 %) patients it was adenocarcinoma of the gallbladder.
  • Other morphologic types are analplastic cancer, carcinosarcoma, and "squamous cell carcinoma".
  • According to the localisation in 60% of cases the cancer was located in fundus, in 30% of cases in corpus,and 10% of cases in the neck of the gallbladder.
  • CONCLUSION: The incidence of the gallbladder cancer in our series is in the slight increase.
  • The quality of life and the survival are inversely correlated with the depth of the invasion and the extent of the spread of the cancer.
  • [MeSH-major] Gallbladder Neoplasms / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17582972.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] bos
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bosnia and Herzegovina
  •  go-up   go-down


35. de la Cruz J, Hidalgo LA, Feliu J, Admella C, Muns R, del Bas M, Suñol X: [Gallbladder adenocarcinoma: tumoral staging, histological prognostic factors and survival]. Cir Esp; 2005 Jan;77(1):18-21
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Gallbladder adenocarcinoma: tumoral staging, histological prognostic factors and survival].
  • [Transliterated title] Adenocarcinoma de vesícula biliar: estadio tumoral, factores pronósticos histológicos y supervivencia.
  • INTRODUCTION: Gallbladder adenocarcinoma is an aggressive tumor and is one of the digestive tract malignancies with the poorest prognosis.
  • Because of loco-regional extension and delayed diagnosis, curative resection is often impossible.
  • To determine histological prognostic factors and survival in relation to tumoral stage at diagnosis, we performed a retrospective study of our patients with gallbladder carcinoma.
  • PATIENTS AND METHOD: Sixty-two patients with gallbladder adenocarcinoma diagnosed over a 15-year period were retrospectively included in this study.
  • CONCLUSIONS: Preoperative diagnosis of gallbladder adenocarcinoma is difficult except in advanced cases.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Gallbladder Neoplasms / mortality. Gallbladder Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16420877.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


36. Liu DC, Yang ZL, Jiang S: Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma. Cancer Biomark; 2010-2011;8(3):113-21
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma.
  • In this study, we investigated the expressions of Msi-1 and ALDH1 in gallbladder adenocarcinoma (n=100), peritumoral tissues (n=46), adenomatous polyp (n=15), and chronic cholecystitis (n=35) using immunohistochemical method.
  • The percentage of cases with positive Msi-1 and ALDH1 expression were significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues, adenomatous polyp and chronic cholecystitis (ps < 0.01).
  • The expression of Msi-1 and ALDH1 was significantly associated with differentiation, tumor mass, lymph node metastasis and invasion of adenocarcinoma.
  • The expression of Msi-1 and ALDH1 was found to be highly consistent in gallbladder adenocarcinoma (p < 0.01).
  • Multivariate Cox regression analysis showed that positive expression of Msi-1 or ALDH1 (p=0.016, p=0.006, respectively) was an independent bad-prognostic predictor in gallbladder adenocarcinoma.
  • Our study suggested that Msi-1 and/or ALDH1 expression might be closely related to the carcinogenesis, progression, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / physiopathology. Biomarkers, Tumor / analysis. Gallbladder Neoplasms / physiopathology. Isoenzymes / analysis. Nerve Tissue Proteins / analysis. RNA-Binding Proteins / analysis. Retinal Dehydrogenase / analysis
  • [MeSH-minor] Adenomatous Polyps / metabolism. Adult. Aged. Cholecystitis / metabolism. Disease Progression. Female. Gallbladder / chemistry. Gallbladder / pathology. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Prognosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 22012766.001).
  • [ISSN] 1875-8592
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Isoenzymes; 0 / MSI1 protein, human; 0 / Nerve Tissue Proteins; 0 / RNA-Binding Proteins; EC 1.2.1.- / aldehyde dehydrogenase 1; EC 1.2.1.36 / Retinal Dehydrogenase
  •  go-up   go-down


37. Jiang WX, Song BG, Tang RY, Fang JP: [Expression of nm23 and KAI1 and their clinical significance in gallbladder adenocarcinoma]. Zhonghua Zhong Liu Za Zhi; 2008 Jun;30(6):441-3
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of nm23 and KAI1 and their clinical significance in gallbladder adenocarcinoma].
  • OBJECTIVE: To investigate the expression of two tumor metastasis suppressor genes nm23 and KAI1 in gallbladder adenocarcinoma, and their clinicopathological significance.
  • METHODS: Specimens and clinical data from 31 gallbladder adenocarcinoma patients were collected.
  • CONCLUSION: The expressions of nm23 and KAI1 proteins are negatively correlated with clinical stage, but positively with histopathological grade in gallbladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Antigens, CD82 / metabolism. Gallbladder Neoplasms / metabolism. NM23 Nucleoside Diphosphate Kinases / metabolism

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19024519.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD82; 0 / NM23 Nucleoside Diphosphate Kinases; EC 2.7.4.6 / NME1 protein, human
  •  go-up   go-down


38. Okada K, Kijima H, Imaizumi T, Hirabayashi K, Matsuyama M, Yazawa N, Oida Y, Dowaki S, Tobita K, Ohtani Y, Tanaka M, Inokuchi S, Makuuchi H: Wall-invasion pattern correlates with survival of patients with gallbladder adenocarcinoma. Anticancer Res; 2009 Feb;29(2):685-91
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Wall-invasion pattern correlates with survival of patients with gallbladder adenocarcinoma.
  • Gallbladder carcinomas (GBC) frequently show vascular invasion and metastasis when the carcinoma cells invade the perimuscular connective tissue (pT2 according to the TNM classification) through the muscular layer.
  • Sixty-six surgically resected gallbladder adenocarcinomas invading the perimuscular connective tissue (pT2) and beyond the gallbladder wall, including the visceral serosa, (pT3/pT4) were examined.
  • In conclusion, the DG invasion pattern is an indicator of high malignant potential and indirectly worsens the prognosis of patients with gallbladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Gallbladder Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19331223.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  •  go-up   go-down


39. Hara S, Kijima H, Okada K, Igarashi Y: Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis. Biomed Res; 2010 Apr;31(2):89-95
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis.
  • An invasive micropapillary variant (IMPV) has recently been described in several organs but has not been reported in the gallbladder.
  • We analyzed the clinicopathologic findings of IMPV and compared them with those of a conventional adenocarcinoma in the gallbladder to clarify the highly aggressive potential of IMPV of gallbladder carcinoma.
  • Ninety consecutive cases of surgically resected gallbladder carcinomas were studied for age, gender, type, depth of invasion and lymph node and distant metastases.
  • Histologically, IMPV of gallbladder carcinoma was characterized by a small cluster of tumor cells lying within clear stromal spaces.
  • IMPV is a useful predictor of regional lymph node metastasis in gallbladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma / pathology. Gallbladder Neoplasms / pathology. Lymph Nodes / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20460736.001).
  • [ISSN] 1880-313X
  • [Journal-full-title] Biomedical research (Tokyo, Japan)
  • [ISO-abbreviation] Biomed. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


40. Wang YK, Zhao W, Hao Y, Zhang Y, Guo YB, Meng NL, Ma L, Li J: [Clinicopathologic features of gallbladder adenocarcinoma with marked stromal fibrosis--a report of 19 cases]. Ai Zheng; 2006 Jul;25(7):896-900
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinicopathologic features of gallbladder adenocarcinoma with marked stromal fibrosis--a report of 19 cases].
  • BACKGROUND & OBJECTIVE: Macropathologic types of gallbladder cancer are mostly polyp type, intumescent type, and cauliflower form lump.
  • Its histological types include well or poorly differentiated adenocarcinoma, mucinous adenocarcinoma, and undifferentiated cancer.
  • This research was to explore the clinicopathologic features of gallbladder adenocarcinoma with marked stromal fibrosis.
  • METHODS: Pathology of 19 cases of gallbladder adenocarcinoma with marked stromal fibrosis was observed using a light microscopy and SP immunohistochemistry.
  • RESULTS: Most of the patients had long-term history of cholecystitis gallbladder calculus.
  • B ultrasound showed that the gallbladder wall was irregularly thickened or presented nodosity.
  • Observed with naked eyes, gallbladder adenocarcinoma with marked stromal fibrosis did not form cancer nodule and extrude into the gallbladder lumen, the gallbladder wall showed regional thickening, a few cases showed diffuse irregular thickening.
  • Observed under a light microscope, the adenocarcinoma cells were mostly arranged as single layers, seldom arranged as multiple layers, and formed adenoid structures with different sizes, various shapes, and irregular arrangement; the nuclei were heterogenic with haryomitosis presented in a few cases; inflammatory cells were infiltrated in hyperplastic fibrous connective tissue of some cases.
  • CONCLUSIONS: The clinical manifestation, macropathologic type, histological characteristics of gallbladder adenocarcinoma with stromal fibrosis are different from other types of adenocarcinoma.
  • Its genesis may be related to chronic cholecystitis: long-term inflammation causes regional hyperplasia and heterogeneity of the gland body, lead to focal or regional thickening of the gallbladder wall, and result in gallbladder adenocarcinoma with stromal fibrosis finally.
  • [MeSH-major] Adenocarcinoma / pathology. Gallbladder / pathology. Gallbladder Neoplasms / pathology. Keratins / metabolism
  • [MeSH-minor] Adult. Aged. Cholecystectomy. Diagnosis, Differential. Female. Fibrosis. Follow-Up Studies. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16831286.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 68238-35-7 / Keratins
  •  go-up   go-down


41. Hori T, Wagata T, Takemoto K, Shigeta T, Takuwa H, Hata K, Uemoto S, Yokoo N: Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction. World J Gastroenterol; 2008 Oct 14;14(38):5933-7
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for gallbladder adenocarcinoma .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction.
  • A 71-year-old Japanese man with acute cholecystitis and an incarcerated gallbladder (GB) stone was admitted.
  • We were agonized in making the qualitative diagnosis of mass-like lesions of the fundus, such as a benign tumor, cancer, or debris.
  • Amylase levels in the common bile duct and gallbladder were quite high.
  • Although this necrotic nodule included non-viable adenocarcinoma cells, viable cancer cell nests were located in the muscularis propria and subcutaneous layer.
  • Histopathological examination confirmed a solid adenocarcinoma.
  • Thus, we diagnosed it as a gallbladder cancer, based on histopathological analysis of the resected specimen.
  • Histopathological findings revealed no cancer, hyperplasia or dysplasia in the additionally resected specimens.
  • We present the first case of spontaneous necrosis of solid gallbladder adenocarcinoma, with a review of previous studies.
  • [MeSH-major] Adenocarcinoma / pathology. Biliary Tract / abnormalities. Gallbladder Neoplasms / pathology. Incidental Findings. Pancreas / abnormalities

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Eur J Surg Oncol. 2006 Mar;32(2):208-12 [16377119.001]
  • [Cites] Vnitr Lek. 2004 Oct;50(10):781-5 [15633935.001]
  • [Cites] Am J Surg. 2007 Sep;194(3):355-61 [17693282.001]
  • [Cites] J Gastrointest Surg. 2007 Sep;11(9):1188-93 [17712596.001]
  • [Cites] Postgrad Med J. 2000 Feb;76(892):96-8 [10644387.001]
  • [Cites] Hepatogastroenterology. 2000 May-Jun;47(33):631-5 [10919001.001]
  • [Cites] J Hepatobiliary Pancreat Surg. 2001;8(1):95-100 [11294297.001]
  • [Cites] Cancer. 2001 Jul 15;92(2):340-8 [11466688.001]
  • [Cites] World J Surg. 2002 Jul;26(7):867-71 [11960212.001]
  • [Cites] Ann Surg Oncol. 2003 May;10(4):447-54 [12734095.001]
  • [Cites] Cancer. 1983 Dec 1;52(11):2086-8 [6627217.001]
  • [Cites] Surg Gastroenterol. 1984;3(2):69-73 [6085899.001]
  • [Cites] Ann Surg. 1992 Apr;215(4):326-31 [1558412.001]
  • [Cites] Eur J Endocrinol. 1994 May;130(5):469-71 [8180674.001]
  • [Cites] Hepatogastroenterology. 1995 Apr;42(2):113-6 [7545638.001]
  • [Cites] Br J Urol. 1995 Oct;76(4):501-3 [7551893.001]
  • [Cites] Surg Endosc. 1997 Dec;11(12):1224-5 [9373301.001]
  • [Cites] Am J Clin Pathol. 1998 Jan;109(1):62-8 [9426519.001]
  • [Cites] Cancer Invest. 1998;16(1):64-5 [9474255.001]
  • [Cites] Cancer. 1998 Aug 1;83(3):423-7 [9690533.001]
  • [Cites] Am Surg. 1998 Aug;64(8):764-7 [9697909.001]
  • [Cites] J Clin Endocrinol Metab. 1953 Aug;13(8):997-1008 [13069604.001]
  • [Cites] World J Gastroenterol. 2006 Apr 28;12(16):2549-55 [16688800.001]
  • (PMID = 18855999.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2751910
  •  go-up   go-down


42. Zaydfudim V, Feurer ID, Wright JK, Pinson CW: The impact of tumor extent (T stage) and lymph node involvement (N stage) on survival after surgical resection for gallbladder adenocarcinoma. HPB (Oxford); 2008;10(6):420-7
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The impact of tumor extent (T stage) and lymph node involvement (N stage) on survival after surgical resection for gallbladder adenocarcinoma.
  • INTRODUCTION: Tumor extent (T stage) and lymph node involvement (N stage) have a known combined negative effect on survival in patients with gallbladder adenocarcinoma, but the independent effects of these factors have been less well described.
  • We investigated whether T stage and N stage independently predict survival after surgery for gallbladder adenocarcinoma.
  • METHODS: We queried the Surveillance, Epidemiology and End Results database for patients treated with surgical resection for gallbladder adenocarcinoma between 1988 and 2004.
  • CONCLUSIONS: Tumor extent and lymph node metastases are independent predictors of survival after surgical resection for gallbladder adenocarcinoma.
  • Tumor penetration of the gallbladder wall and pathologically confirmed lymph node involvement each carry poor prognosis.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Eur J Surg Oncol. 2008 Mar;34(3):306-12 [17964753.001]
  • [Cites] Br J Surg. 2000 Apr;87(4):418-22 [10759735.001]
  • [Cites] J Gastrointest Surg. 2007 May;11(5):671-81 [17468929.001]
  • [Cites] J Gastrointest Surg. 2007 Feb;11(2):158-65 [17390167.001]
  • [Cites] Surg Oncol Clin N Am. 2007 Jan;16(1):221-32 [17336245.001]
  • [Cites] Ann Surg Oncol. 2007 Feb;14(2):827-32 [17109082.001]
  • [Cites] Ann Surg Oncol. 2007 Feb;14(2):833-40 [17103074.001]
  • [Cites] J Surg Oncol. 2006 Jun 15;93(8):670-81 [16724356.001]
  • [Cites] Ann Surg. 2005 Mar;241(3):395-6 [15729061.001]
  • [Cites] Ann Surg. 2005 Mar;241(3):385-94 [15729060.001]
  • [Cites] Surgery. 1999 Mar;125(3):250-6 [10076608.001]
  • [Cites] Cancer. 1998 Dec 15;83(12):2618-28 [9874470.001]
  • [Cites] Cancer. 1997 Mar 1;79(5):892-9 [9041150.001]
  • [Cites] Ann Surg. 1996 Nov;224(5):639-46 [8916879.001]
  • [Cites] Biometrics. 1973 Sep;29(3):579-84 [4793138.001]
  • [Cites] Ann Surg. 2003 Apr;237(4):509-14 [12677147.001]
  • [Cites] Am Surg. 2001 Nov;67(11):1041-7 [11730220.001]
  • [Cites] Ann Surg. 2000 Oct;232(4):557-69 [10998654.001]
  • [Cites] J Surg Oncol. 2007 Jul 1;96(1):8-13 [17516546.001]
  • (PMID = 19088928.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] ENG
  • [Grant] United States / AHRQ HHS / HS / T32 HS013833
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2597319
  • [Keywords] NOTNLM ; SEER registry / gallbladder cancer / lymph node metastases / survival / tumor extent
  •  go-up   go-down


43. Okada K, Kijima H, Imaizumi T, Hirabayashi K, Matsuyama M, Yazawa N, Oida Y, Dowaki S, Tobita K, Ohtani Y, Tanaka M, Inokuchi S, Makuuchi H: Stromal laminin-5gamma2 chain expression is associated with the wall-invasion pattern of gallbladder adenocarcinoma. Biomed Res; 2009 Feb;30(1):53-62
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stromal laminin-5gamma2 chain expression is associated with the wall-invasion pattern of gallbladder adenocarcinoma.
  • Our previous study demonstrated that the pT2 and pT3-4 gallbladder carcinomas can be classified into two groups, i.e. infiltrative growth type (IG type) and destructive growth type (DG type) and that the DG type is associated with poor differentiation, aggressive infiltration, and decreased postoperative survival.
  • The present study focused on the clinicopathologic significance of laminin-5gamma2 chain expression as an indicator of local aggressiveness and Ki-67 labeling index (Ki-67 LI) as an indicator of the cell proliferation activity of gallbladder carcinoma.
  • Gallbladder carcinoma cases with high Ki-67 LI were significantly associated with poorly differentiation (P = 0.089) and distant lymph node metastasis (P = 0.079).
  • Laminin-5gamma2 expression patterns of gallbladder carcinoma were divided into two distinct types, extracellular staining and cytoplasmic staining.
  • The cytoplasmic staining was not significantly correlated with invasion pattern in gallbladder carcinoma (P = 0.545).
  • In conclusion, high-grade cell proliferation and stromal laminin-5gamma2 staining were significantly correlated with a wall-invasion pattern of aggressive gallbladder carcinoma indicating destructive growth (DG type).
  • [MeSH-major] Gallbladder Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Laminin / biosynthesis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19265264.001).
  • [ISSN] 1880-313X
  • [Journal-full-title] Biomedical research (Tokyo, Japan)
  • [ISO-abbreviation] Biomed. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / LAMC2 protein, human; 0 / Laminin
  •  go-up   go-down


44. Kawanishi M, Kuwada Y, Mitsuoka Y, Sasao S, Mouri T, Takesaki E, Takahashi T, Toyota K, Nakatani T: A case of double gallbladder with adenocarcinoma arising from the left hepatic duct: a case report and review of the literature. Gastroenterol Res Pract; 2010;2010

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of double gallbladder with adenocarcinoma arising from the left hepatic duct: a case report and review of the literature.
  • Double gallbladder is a rare congenital biliary anomaly, but an accessory gallbladder arising from the left hepatic duct is a more remarkably rare congenital anomaly.
  • We report a case of double gallbladder with adenocarcinoma and gallstones, which was preoperatively diagnosed by endoscopic retrograde cholangiopancreatography (ERCP) and then confirmed by open laparotomy.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20811488.001).
  • [ISSN] 1687-630X
  • [Journal-full-title] Gastroenterology research and practice
  • [ISO-abbreviation] Gastroenterol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2926673
  •  go-up   go-down


45. Galvão FH, Pestana JO, Capelozzi VL: Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma. Cancer Chemother Pharmacol; 2010 Feb;65(3):607-10
MedlinePlus Health Information. consumer health - Interstitial Lung Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma.
  • In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma.
  • A 72-year-old patient was submitted to an elective laparoscopic cholecystectomy, and a tubular adenocarcinoma in the gallbladder was incidentally diagnosed.
  • The colonic lesion was conveniently removed and the histology evaluation confirmed the diagnosis of adenocarcinoma tubular.
  • [MeSH-major] Adenocarcinoma / drug therapy. Deoxycytidine / analogs & derivatives. Gallbladder Neoplasms / drug therapy. Lung Diseases, Interstitial / chemically induced

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cancer Invest. 2002;20(7-8):876-9 [12449717.001]
  • [Cites] J Thorac Oncol. 2009 Jul;4(7):845-52 [19487963.001]
  • [Cites] Br J Dermatol. 1997 Feb;136(2):279-82 [9068751.001]
  • [Cites] Cancer. 1997 Jul 15;80(2):286-91 [9217042.001]
  • [Cites] Cancer. 2006 May 1;106(9):2051-7 [16568459.001]
  • [Cites] Br J Cancer. 2006 Jun 5;94(11):1759-60 [16685265.001]
  • [Cites] J Thorac Oncol. 2006 Jun;1(5):434-40 [17409896.001]
  • [Cites] Anticancer Drugs. 2007 Oct;18(9):1109-11 [17704662.001]
  • [Cites] Invest New Drugs. 2008 Feb;26(1):67-74 [17805486.001]
  • [Cites] Gan To Kagaku Ryoho. 2008 Jan;35(1):133-6 [18195543.001]
  • [Cites] Chest. 2008 Feb;133(2):528-38 [18252919.001]
  • [Cites] Eur J Gynaecol Oncol. 2008;29(2):179-81 [18459559.001]
  • [Cites] Oncologist. 2008 Jul;13(7):807-11 [18614588.001]
  • [Cites] Hum Pathol. 2008 Sep;39(9):1275-94 [18706349.001]
  • [Cites] JOP. 2008;9(6):708-14 [18981552.001]
  • [Cites] Arch Gynecol Obstet. 2009 Feb;279(2):251-4 [18548263.001]
  • [Cites] Eur J Med Res. 2009;14:90-2 [19258219.001]
  • [Cites] Clin Pharmacol Ther. 1981 Aug;30(2):239-45 [7249508.001]
  • (PMID = 19904536.001).
  • [ISSN] 1432-0843
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
  •  go-up   go-down


46. Oshiro H, Matsuo K, Mawatari H, Inayama Y, Yamanaka S, Nagahama K, Endo I, Shimada H, Nakajima A, Kubota K: Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction. Pathol Int; 2008 Dec;58(12):780-6
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction.
  • Herein is reported a case of mucin-producing carcinoma of the gallbladder in a 55-year-old Japanese woman.
  • Although the patient's status and laboratory data initially suggested biliary pancreatitis due to gallstone, radiography and endoscopy confirmed the presence of pancreaticobiliary maljunction and a gallbladder tumor with excessive mucin, in which the duodenal papilla and the common bile duct were impacted.
  • Following surgery, the gallbladder tumor was histopathologically diagnosed as a mixed endocrine-exocrine carcinoma.
  • There was no evidence of lymph node metastasis, distant metastasis, or direct invasion outside the gallbladder.
  • Thus, the final classification of pT2N0M0 stage II was given to this lesion, according to the Union Internationale Contre le Cancer guidelines.
  • Mucin-producing gallbladder carcinoma is a rare clinical condition that can occur in patients with pancreaticobiliary maljunction.
  • [MeSH-major] Adenocarcinoma / pathology. Common Bile Duct / abnormalities. Gallbladder Neoplasms / pathology. Mucins / metabolism. Pancreatic Ducts / abnormalities

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19067853.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
  •  go-up   go-down


47. Ooi A, Suzuki S, Nakazawa K, Itakura J, Imoto I, Nakamura H, Dobashi Y: Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma. Anticancer Res; 2009 Jan;29(1):19-26
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma.
  • BACKGROUND: Among the combinations of coamplified genes, Myc and ERBB2 or EGFR have attracted much attention for their relevance to cytogenetics, carcinogenesis and cancer therapy.
  • MATERIALS AND METHODS: Gene amplification of Myc, ERBB2 and EGFR were examined on 97 formalin-fixed and paraffin-embedded gallbladder carcinomas, by fluorescence in situ hybridization (FISH).
  • [MeSH-major] Adenocarcinoma / genetics. Gallbladder Neoplasms / genetics. Genes, myc. Receptor, Epidermal Growth Factor / genetics. Receptor, ErbB-2 / genetics

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19331129.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
  •  go-up   go-down


48. Mayo SC, Shore AD, Nathan H, Edil B, Wolfgang CL, Hirose K, Herman J, Schulick RD, Choti MA, Pawlik TM: National trends in the management and survival of surgically managed gallbladder adenocarcinoma over 15 years: a population-based analysis. J Gastrointest Surg; 2010 Oct;14(10):1578-91
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] National trends in the management and survival of surgically managed gallbladder adenocarcinoma over 15 years: a population-based analysis.
  • INTRODUCTION: National Comprehensive Cancer Network (NCCN) guidelines recommend hepatic resection and lymphadenectomy (LND) for gallbladder adenocarcinoma (GBA).
  • METHODS: Using Surveillance, Epidemiology and End Results (SEER)-Medicare-linked data, we identified 2,955 patients with GBA who underwent cancer-directed surgery from 1991 to 2005.
  • [MeSH-major] Adenocarcinoma / surgery. Gallbladder Neoplasms / surgery. SEER Program

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Am Coll Surg. 2008 Sep;207(3):371-82 [18722943.001]
  • [Cites] J Gastrointest Surg. 2008 May;12(5):842-51 [18266046.001]
  • [Cites] Ann Surg Oncol. 2008 Feb;15(2):415-23 [17987343.001]
  • [Cites] Am Surg. 2001 Nov;67(11):1041-7 [11730220.001]
  • [Cites] Am J Surg. 1997 Jun;173(6):467-71 [9207156.001]
  • [Cites] J Gastrointest Surg. 2009 Apr;13(4):722-7 [19083068.001]
  • [Cites] Ann Surg Oncol. 2009 Apr;16(4):787-8 [19165545.001]
  • [Cites] Ann Surg Oncol. 2009 Aug;16(8):2101-15 [19495882.001]
  • [Cites] Ann Surg. 2007 Jan;245(1):73-9 [17197968.001]
  • [Cites] J Gastrointest Surg. 2006 Jun;10(6):848-54 [16769541.001]
  • [Cites] Ann Surg. 1994 Aug;220(2):199-205 [8053742.001]
  • [Cites] AJR Am J Roentgenol. 2008 Jan;190(1):74-80 [18094296.001]
  • [Cites] Lifetime Data Anal. 1998;4(2):109-20 [9658770.001]
  • [Cites] Ann Surg. 2007 Jun;245(6):893-901 [17522515.001]
  • [Cites] J Gastroenterol Hepatol. 2005 Feb;20(2):304-8 [15683436.001]
  • [Cites] Med Care. 2002 Aug;40(8 Suppl):IV-3-18 [12187163.001]
  • [Cites] Ann Surg Oncol. 2007 Feb;14(2):833-40 [17103074.001]
  • [Cites] Ann Surg Oncol. 2009 Apr;16(4):806-16 [18985272.001]
  • [Cites] Arch Surg. 2009 May;144(5):441-7; discussion 447 [19451486.001]
  • [Cites] Annu Rev Med. 2005;56:139-56 [15660506.001]
  • [Cites] Radiol Med. 2008 Apr;113(3):414-28 [18493777.001]
  • [Cites] Am J Surg. 2007 Dec;194(6):820-5; discussion 825-6 [18005778.001]
  • [Cites] Arch Surg. 2003 Jul;138(7):741-50; discussion 750 [12860755.001]
  • [Cites] J Surg Oncol. 2008 Feb 1;97(2):156-64 [18050290.001]
  • [Cites] J Am Coll Surg. 2008 Jan;206(1):57-65 [18155569.001]
  • [Cites] Hepatogastroenterology. 1998 Jan-Feb;45(19):184-90 [9496510.001]
  • [Cites] Adv Surg. 2001;35:1-20 [11579805.001]
  • [Cites] Abdom Imaging. 2008 Sep-Oct;33(5):520-8 [17912584.001]
  • [Cites] Med Care. 2002 Aug;40(8 Suppl):IV-43-8 [12187167.001]
  • [Cites] J Gastrointest Surg. 2007 Nov;11(11):1478-86; discussion 1486-7 [17846848.001]
  • [Cites] Ann Surg. 1983 Apr;197(4):375-88 [6299217.001]
  • [Cites] Hepatogastroenterology. 1992 Jun;39(3):237-41 [1505895.001]
  • [Cites] J Magn Reson Imaging. 2009 Sep;30(3):586-95 [19711405.001]
  • [Cites] Surgery. 2009 Oct;146(4):706-11; discussion 711-3 [19789030.001]
  • [Cites] Ann Surg. 2000 Oct;232(4):557-69 [10998654.001]
  • [Cites] J Am Coll Surg. 1997 Dec;185(6):554-9 [9404879.001]
  • [Cites] Ann Surg. 2005 Mar;241(3):385-94 [15729060.001]
  • [Cites] Ann Surg. 1999 Sep;230(3):309-18; discussion 318-21 [10493478.001]
  • [Cites] Med Care. 2002 Aug;40(8 Suppl):IV-62-8 [12187170.001]
  • [Cites] Ann Surg. 1994 Mar;219(3):275-80 [8147608.001]
  • (PMID = 20824371.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


49. Sato S, Ishii M, Fujihira T, Ito E, Ohtani Y: Gallbladder adenocarcinoma with human chorionic gonadotropin: a case report and review of literature. Diagn Pathol; 2010;5:46
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for gallbladder adenocarcinoma .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gallbladder adenocarcinoma with human chorionic gonadotropin: a case report and review of literature.
  • BACKGROUND: The case of adenocarcinoma with human chorionic gonadtropin (HCG), primary in the male gallbladder, is extremely rare.
  • METHODS: We herein describe a case of primary gallbladder adenocarcinoma associated by ectopic HCG positive tumor cells in a 79-year-old male.
  • RESULTS: Pathological examination showed a mixture of moderately and poorly differentiated adenocarcinoma with ectopic HCG and placental alkaline phosphatase (PlAP) in tumor cells, though the increase of serum or urinary HCG secretion was not confirmed.
  • CONCLUSIONS: A case of gallbladder cancer with ectopic HCG production is quite rare in the literature, though many similar cases in other site, especially in GI tract, are reported.
  • [MeSH-major] Adenocarcinoma / chemistry. Chorionic Gonadotropin / analysis. Gallbladder Neoplasms / chemistry

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cancer. 2001 Jan 1;91(1):123-9 [11148568.001]
  • [Cites] Virchows Arch. 2010 Jan;456(1):65-70 [20013345.001]
  • [Cites] J Cell Biol. 1967 May;33(2):307-18 [6046571.001]
  • [Cites] Cancer. 1971 Mar;27(3):694-702 [5102373.001]
  • [Cites] Ann Intern Med. 1973 Jan;78(1):39-45 [4734160.001]
  • [Cites] Hum Pathol. 1976 Sep;7(5):595-604 [987011.001]
  • [Cites] Cancer. 1976 Oct;38(4):1684-6 [991086.001]
  • [Cites] Cancer. 1978 Nov;42(5):2328-33 [719611.001]
  • [Cites] Cancer. 1980 May 15;45(10):2583-92 [7378992.001]
  • [Cites] Cancer. 1980 Aug 1;46(3):570-5 [7190461.001]
  • [Cites] Arch Pathol Lab Med. 1981 Jun;105(6):287-93 [6263212.001]
  • [Cites] Am J Surg Pathol. 1981 Jun;5(4):333-42 [7196700.001]
  • [Cites] Virchows Arch A Pathol Anat Histol. 1982;396(2):141-53 [6750912.001]
  • [Cites] Acta Pathol Jpn. 1983 Mar;33(2):287-96 [6869003.001]
  • [Cites] Cancer. 1984 Sep 1;54(5):866-8 [6540137.001]
  • [Cites] Neurosurgery. 1984 Oct;15(4):540-5 [6541765.001]
  • [Cites] Arch Pathol Lab Med. 1987 May;111(5):477-9 [3551876.001]
  • [Cites] Virchows Arch A Pathol Anat Histopathol. 1987;411(3):205-12 [2441515.001]
  • [Cites] Cancer. 1988 May 1;61(9):1872-9 [2451557.001]
  • [Cites] Eur J Surg Oncol. 1989 Apr;15(2):103-8 [2703054.001]
  • [Cites] Am J Gastroenterol. 1990 Oct;85(10):1403-6 [2220737.001]
  • [Cites] Hum Pathol. 1991 Jun;22(6):614-5 [1864593.001]
  • [Cites] Gastric Cancer. 2005;8(3):178-85 [16086121.001]
  • [Cites] J Histochem Cytochem. 1966 Dec;14(12):929-31 [17121392.001]
  • [Cites] Gynecol Oncol. 2008 Feb;108(2):452-4 [18078982.001]
  • [Cites] Indian J Pathol Microbiol. 2009 Oct-Dec;52(4):537-9 [19805966.001]
  • [Cites] Med Oncol. 2001;18(2):165-9 [11778764.001]
  • (PMID = 20594358.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / GPI-Linked Proteins; 0 / Isoenzymes; EC 3.1.3.1 / Alkaline Phosphatase; EC 3.1.3.1 / alkaline phosphatase, placental
  • [Other-IDs] NLM/ PMC2910002
  •  go-up   go-down


50. Turrini R, Lanzani G, Salmi A: [Gallbladder adenoma with focal adenocarcinoma: a case report]. Recenti Prog Med; 2007 Oct;98(10):506-8
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Gallbladder adenoma with focal adenocarcinoma: a case report].
  • [Transliterated title] Adenoma con focale adenocarcinoma della colecisti: descrizione di un caso.
  • Gallbladder polyps represent a frequent and asymptomatic finding on abdominal sonography.
  • We describe the ultrasound features of an asymptomatic 13-mm gallbladder polyp in a 29-year-old male.
  • To our knowledge, this is the first report of a gallbladder polyp already presenting severe dysplasia in a young Caucasian male without risk factors.
  • [MeSH-major] Adenoma / diagnosis. Cholecystectomy, Laparoscopic. Gallbladder Neoplasms / diagnosis. Polyps / complications
  • [MeSH-minor] Adult. Cholecystitis / complications. Cholecystitis / diagnosis. Cholecystitis / surgery. Chronic Disease. Humans. Male. Video-Assisted Surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17970176.001).
  • [ISSN] 0034-1193
  • [Journal-full-title] Recenti progressi in medicina
  • [ISO-abbreviation] Recenti Prog Med
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


51. Eltawil KM, Gustafsson BI, Kidd M, Modlin IM: Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy. J Clin Gastroenterol; 2010 Nov-Dec;44(10):687-95
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy.
  • BACKGROUND: Gallbladder neuroendocrine tumors (GB-NETs) represent only 0.5% of all NETs, and little is known about their biological behavior.
  • STUDY: A PubMed search was undertaken using the following criteria: primary gallbladder and carcinoid or NET.
  • Finally, we compared the clinical presentation, management and prognosis of GB-NETs to that of gallbladder adenocarcinoma.
  • RESULTS: GB-NETs probably derive from either a multipotent stem cell or neuroendocrine cells in intestinal or gastric metaplasia of the gallbladder epithelium, which occurs consequent upon cholelithiasis/chronic inflammation.
  • Clinically and at surgery, GB-NETs are indistinguishable from gallbladder cancer (GBC) and "carcinoid syndrome" is evident in only ∼1%.The median survival was only 9.8 months among 278 cases of GB-NETs reported in SEER.
  • The 5 year survival rate for tumors classified as carcinoids/neuroendocrine carcinoma or small cell cancer (SCC) was 36.9 and 0%, respectively.
  • [MeSH-major] Gallbladder Neoplasms / therapy. Neuroendocrine Tumors / therapy

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20375728.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  •  go-up   go-down


52. Legan M, Luzar B, Ferlan-Marolt V, Cör A: Cyclooxygenase-2 expression determines neo-angiogenesis in gallbladder carcinomas. Bosn J Basic Med Sci; 2006 Nov;6(4):58-63
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclooxygenase-2 expression determines neo-angiogenesis in gallbladder carcinomas.
  • Neo-angiogenesis may have an important role in the poor prognosis of gallbladder carcinoma.
  • An enhanced expression of COX-2 was found in precancerous lesions and in gallbladder carcinoma, likely to be involved in carcinogenesis as well as in angiogenesis.
  • To study the relationships between the COX-2 expression and degree of vascularization, as well as to evaluate their role in the prognosis of patients with gallbladder carcinoma.
  • 27 cases of gallbladder adenocarcinoma were included, classified grading I-III according the WHO classification.
  • Our data show that the MVD corresponds to the COX-2 overexpression in gallbladder carcinomas.
  • Augmented tumor neovascularization induced by COX-2 might be responsible for the poor prognosis in gallbladder carcinoma patients.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17177652.001).
  • [ISSN] 1512-8601
  • [Journal-full-title] Bosnian journal of basic medical sciences
  • [ISO-abbreviation] Bosn J Basic Med Sci
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Bosnia and Herzegovina
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / ENG protein, human; 0 / Receptors, Cell Surface; EC 1.14.99.1 / Cyclooxygenase 2
  •  go-up   go-down


53. Lynch BC, Lathrop SL, Ye D, Ma TY, Cerilli LA: Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder. Ann Diagn Pathol; 2008 Jun;12(3):161-4
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder.
  • The sequence of molecular changes leading to neoplastic transformation in the gallbladder remains elusive.
  • The aim of this study is to characterize the spectrum of nuclear p16 protein product immunohistochemical expression in tissue microarray cores taken from resected gallbladders, comprising histologically normal gallbladder epithelia (n = 29), dyplastic epithelia (n = 19), reactive atypia (n = 7), and gallbladder adenocarcinoma (n = 23).
  • Our data demonstrate that nuclear p16 expression is absent in normal gallbladder epithelium and is a frequent event in high-grade dysplasia of the gallbladder and gallbladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Carcinoma in Situ / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Epithelial Cells / metabolism. Gallbladder Neoplasms / metabolism. Precancerous Conditions / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Gallbladder / metabolism. Gallbladder / pathology. Humans. Immunoenzyme Techniques. Tissue Array Analysis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18486890.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16
  •  go-up   go-down


54. Zhang L, Han F, Huang CS, Pang C, Han YZ, Hua YW: [Analysis of the treatment of unexpected gallbladder cancer]. Zhonghua Wai Ke Za Zhi; 2005 Apr 1;43(7):460-2
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of the treatment of unexpected gallbladder cancer].
  • OBJECTIVE: To investigate the secondary operation methods and the effects on the prognosis of unexpected gallbladder cancer (UGC).
  • The 41 patients had undergone gallbladder excision because of cholecystitis complicated lithiasis of gallbladder (32 cases), polypi of gallbladder or adenoma (9 cases).
  • Postoperative pathology showed that 32 cases were adenocarcinoma of gallbladder, 6 cases were squamous carcinoma, 3 cases were squamous adenocarcinoma.
  • The second operation chose the improved method of Glenn excision of carcinoma of gallbladder.
  • RESULTS: On the second operation, 14 cases were with lymphatic metastasis, 14 with gallbladder metastasis, 6 with bile duct metastasis, 2 with pancreas metastasis.
  • [MeSH-major] Cholecystectomy / methods. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15854374.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  •  go-up   go-down


55. Martínez-Román S, Frumovitz M, Deavers MT, Ramirez PT: Metastatic carcinoma of the gallbladder mimicking an advanced cervical carcinoma. Gynecol Oncol; 2005 Jun;97(3):942-5
International Agency for Research on Cancer - Screening Group. diagnostics - A practical manual on visual screening for cervical neoplasia .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic carcinoma of the gallbladder mimicking an advanced cervical carcinoma.
  • To our knowledge, only three cases of primary carcinoma of the gallbladder with metastasis to the cervix have been previously reported.
  • We report a case of metastatic gallbladder carcinoma mimicking a stage IIIB cervical carcinoma.
  • A Pap smear revealed adenocarcinoma, and a biopsy of the endocervical canal was consistent with poorly differentiated adenocarcinoma.
  • A chest CT revealed multiple lesions in both lungs suggestive of metastatic disease, and an abdominal CT revealed a gallbladder tumor with extension into the liver.
  • The patient underwent a CT-guided biopsy of one of the lung lesions and the pathologic findings were consistent with metastatic adenocarcinoma.
  • The patient was diagnosed with stage IVB primary gallbladder adenocarcinoma and was treated with capecitabine, but her condition deteriorated rapidly and she died 5 months later.
  • CONCLUSION: In patients with an atypical presentation for cervical adenocarcinoma, it is important to consider a metastatic tumor in the differential diagnosis and to perform a thorough work-up for metastatic disease before initiating therapy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / pathology. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans


56. Liu DC, Yang ZL, Yang LP: [Expression of enhancer of zesle homolog 2 and phosphatase and tension homolog and its clinicopathological significance in benign and malignant lesion of gallbladder]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 Jul;33(7):618-22
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of enhancer of zesle homolog 2 and phosphatase and tension homolog and its clinicopathological significance in benign and malignant lesion of gallbladder].
  • OBJECTIVE: To examine the expressive level of enhancer of zesle homolog 2 (EZH2) and phosphatase and tension homolog (PTEN), and to explore its clinicopathological significance in benign and malignant lesion of gallbladder.
  • METHODS: EnVision immunohistochemical method was used to detect the expressive levels of EZH2 and PTEN in routinely paraffin-embedded sections in the resected specimens of gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenomatous polyp(n = 15), and chronic cholecystitis (n = 35).
  • RESULTS: The positive rate of EZH2 was significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues (chi(2) = 24.49, P < 0.01), adenomatous polyp(chi(2) = 11.68, P < 0.01), and chronic cholecystitis (chi(2) = 31.62, P < 0.01).
  • The benign lesions in the positive cases of EZH2 and (or) the negative ones of PTEN showed the moderately- or severely- atypical hyperplasia of gallbladder epithelium.
  • The positive rate of PTEN was significantly lower in gallbladder adenocarcinoma than that in peritumoral tissues(n = 20.20, P < 0.01), adenomatous polyp(chi(2)=10.81, P<0.01), and chronic cholecystitis (n = 29.83, P < 0.01).The positive rates of EZH2 were significantly lower in the highly-differentiated adenocarcinoma, the maximal diameter of mass < 2 cm, non-metastasis of lymphnodes, and non-infiltration of regional tissues than those in the moderately or low-differentiated adenocarcinoma, the maximal diameter > or = 2 cm, metastasis of lymphnode, and infiltration of regional tissues (P < 0.05 or P < 0.01).
  • High inconsistency was found between the expression of EZH2 and PTEN in gallbladder adenocarcinoma (P < 0.05).
  • CONCLUSION: Expression of EZH2 and/or PTEN might be important biological markers in the carcinogenesis, progression, biological behaviors and prognosis of gallbladder adenocarcinoma.
  • [MeSH-major] DNA-Binding Proteins / biosynthesis. Gallbladder Neoplasms / genetics. PTEN Phosphohydrolase / biosynthesis. Transcription Factors / biosynthesis
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adult. Biomarkers, Tumor. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Polycomb Repressive Complex 2. Prognosis

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18667776.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Transcription Factors; EC 2.1.1.43 / EZH2 protein, human; EC 2.1.1.43 / Polycomb Repressive Complex 2; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
  •  go-up   go-down


57. Terada T: Gallbladder adenocarcinoma arising in Rokitansky-Aschoff sinus. Pathol Int; 2008 Dec;58(12):806-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gallbladder adenocarcinoma arising in Rokitansky-Aschoff sinus.
  • Herein is reported a case of minute adenocarcinoma arising in RAS.
  • A 77-year-old Japanese man with gallbladder stones underwent cholecystectomy.
  • It was adenocarcinoma.
  • RAS were recognized within the tumor, and there was a gradual transition between RAS and the adenocarcinoma.
  • Mucin histochemistry indicated neutral and acidic mucins in the cytoplasm and lumens of the adenocarcinoma cells.
  • Immunohistochemistry showed that the adenocarcinoma cells were positive for cytokeratin, epithelial membrane antigen, carbohydrate antigen 19-9, K-i67 (labeling=80%), MUC1, MUC5AC and MUC6.
  • In contrast, the adenocarcinoma cells were negative for CEA, c-erbB2, p53 protein, MUC2 and CD10.
  • In summary, minute subserosal adenocarcinoma, which arose in RAS, was found incidentally; therefore careful examination of resected gallbladders is necessary.
  • [MeSH-major] Adenocarcinoma / pathology. Gallbladder / pathology. Gallbladder Neoplasms / pathology


58. Qayyum A, Mujtaba I: Effects of chemotherapy on patients with unresectable or metastatic adenocarcinoma of gallbladder. J Pak Med Assoc; 2007 Feb;57(2):71-4
Hazardous Substances Data Bank. LEUCOVORIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of chemotherapy on patients with unresectable or metastatic adenocarcinoma of gallbladder.
  • OBJECTIVE: To evaluate the effect of combination chemotherapy on disease status, toxicity and survival of patients with unresectable locally advanced or metastatic adenocarcinoma of gallbladder.
  • METHODS: Single arm study of twenty patients, with unresectable locally advanced or metastatic adenocarcinoma of gallbladder, who presented to oncology clinic at Ziauddin Hospital Nazimabad Karachi from January 1997 to December 1998.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Gallbladder Neoplasms / drug therapy

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • Hazardous Substances Data Bank. FLUOROURACIL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17370788.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 12001-76-2 / Vitamin B Complex; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
  •  go-up   go-down


59. Kim WS, Choi DW, You DD, Ho CY, Heo JS, Choi SH: Risk factors influencing recurrence, patterns of recurrence, and the efficacy of adjuvant therapy after radical resection for gallbladder carcinoma. J Gastrointest Surg; 2010 Apr;14(4):679-87
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors influencing recurrence, patterns of recurrence, and the efficacy of adjuvant therapy after radical resection for gallbladder carcinoma.
  • BACKGROUNDS: Gallbladder carcinoma (GBC) is an aggressive neoplasm, and resection is the only curative modality.
  • METHODS: The records of patients that underwent surgical resection with curative intent for gallbladder carcinoma from October 1994 and August 2007 were retrospectively reviewed.
  • RESULTS: One hundred sixty-six patients underwent surgical resection with curative intent for gallbladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Gallbladder Neoplasms / pathology. Gallbladder Neoplasms / surgery. Neoplasm Recurrence, Local / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Int J Radiat Oncol Biol Phys. 2002 Jan 1;52(1):167-75 [11777635.001]
  • [Cites] Ann Surg. 2005 Mar;241(3):395-6 [15729061.001]
  • [Cites] Cancer. 2003 Oct 15;98(8):1689-700 [14534886.001]
  • [Cites] Ann Surg. 1996 Nov;224(5):639-46 [8916879.001]
  • [Cites] Lancet Oncol. 2003 Mar;4(3):167-76 [12623362.001]
  • [Cites] Cancer. 2002 Oct 15;95(8):1685-95 [12365016.001]
  • [Cites] Cancer. 2000 Aug 15;89(4):757-62 [10951337.001]
  • [Cites] World J Surg. 1991 May-Jun;15(3):357-66 [1853615.001]
  • [Cites] Surg Gynecol Obstet. 1978 Dec;147(6):929-42 [362580.001]
  • [Cites] Rev Med Chil. 2004 Jan;132(1):51-7 [15379053.001]
  • [Cites] Curr Probl Surg. 1995 Jan;32(1):1-90 [7528652.001]
  • [Cites] J Gastrointest Surg. 2007 May;11(5):631-7 [17468922.001]
  • [Cites] Br J Surg. 1999 May;86(5):622-7 [10361182.001]
  • [Cites] J Surg Oncol. 2008 Feb 1;97(2):156-64 [18050290.001]
  • [Cites] Hepatogastroenterology. 2004 Nov-Dec;51(60):1609-11 [15532788.001]
  • [Cites] Br J Surg. 1997 Feb;84(2):200-4 [9052434.001]
  • [Cites] Adv Surg. 2001;35:1-20 [11579805.001]
  • [Cites] Cancer. 2004 Aug 1;101(3):578-86 [15274071.001]
  • [Cites] J Hepatobiliary Pancreat Surg. 2001;8(6):530-4 [11956904.001]
  • [Cites] Surgery. 1996 Nov;120(5):816-21 [8909516.001]
  • [Cites] Br J Surg. 1989 May;76(5):448-50 [2472186.001]
  • [Cites] J Gastrointest Surg. 2004 Jan;8(1):83-9; discussion 89 [14746839.001]
  • [Cites] Radiother Oncol. 1994 Dec;33(3):204-8 [7536333.001]
  • [Cites] Ann Surg. 2000 Oct;232(4):557-69 [10998654.001]
  • [Cites] Ann Surg. 1992 Nov;216(5):565-8 [1359844.001]
  • [Cites] Ann Surg. 1994 Mar;219(3):275-80 [8147608.001]
  • [Cites] Am J Surg. 1992 Feb;163(2):239-45 [1739180.001]
  • (PMID = 20094817.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


60. Yang LP, Yang ZL, Tan XG, Miao XY: [Expression of annexin A1 (ANXA1) and A2 (ANXA2) and its significance in benign and malignant lesions of gallbladder]. Zhonghua Zhong Liu Za Zhi; 2010 Aug;32(8):595-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of annexin A1 (ANXA1) and A2 (ANXA2) and its significance in benign and malignant lesions of gallbladder].
  • OBJECTIVE: To study the expression levels of ANXA1 and ANXA2 and elucidate their clinicopathological significance in adenocarcinoma, peritumoral tissues, adenomatous polyp and chronic cholecystitis of gallbladder.
  • METHODS: EnVision(TM) immunohistochemical staining was used to detect the expression of ANXA1 and ANXA2 in paraffin-embedded tissue sections from resected specimens of adenocarcinoma (n = 108), peritumoral tissue (n = 46), adenomatous polyp (n = 15) and chronic cholecystitis (n = 35).
  • RESULTS: The positive rates and scores of ANXA1 and ANXA2 were significantly higher in adenocarcinoma (59.3%, 56.5%; 3.2 ± 0.9, 3.4 ± 0.8) than those in peritumoral tissues (34.8%, 1.1 ± 0.8, P < 0.01; 30.4%, 1.0 ± 0.8, P < 0.01), adenomatous polyp (26.7%, 0.9 ± 0.7, P < 0.05 or P < 0.01; 26.7%, 0.9 ± 0.8, P < 0.05 or P < 0.01) and chronic cholecystitis (17.1%, 0.7 ± 0.9, P < 0.01; 20.0%, 0.8 ± 0.8, P < 0.01).
  • The benign lesions with positive ANXA1 and/or ANXA2 expression showed mild to severe atypical hyperplasia of the gallbladder epithelium.
  • The positive rates of ANXA1 and/or ANXA2 were significantly lower in the well-differentiated adenocarcinoma, in a maximal diameter of < 2 cm, with no metastasis to lymph nodes and no invasion to surrounding tissues than those in the moderately or poorly-differentiated adenocarcinoma, in a maximal diameter of ≥ 2 cm, with metastasis to lymph nodes and invasion in surrounding tissues (P < 0.05 or P < 0.01).
  • A high consistence was found between the expression levels of ANXA1 and ANXA2 (χ(2) = 67.84, P < 0.01), and a close positive correlation between the scores of ANXA1 and ANXA2 (r = 0.78, P < 0.01) in gallbladder adenocarcinoma.
  • Kaplan-Meier analysis and multivariate Cox regression analysis showed that ANXA1 or ANXA2 was not an independent prognostic predictor in gallbladder adenocarcinoma.
  • CONCLUSION: The expression levels of ANXA1 and/or ANXA2 may be important biological markers in the carcinogenesis, progression and biological behaviors of gallbladder adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Annexin A1 / metabolism. Annexin A2 / metabolism. Gallbladder Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Adenomatous Polyps / metabolism. Adenomatous Polyps / pathology. Adult. Aged. Cholecystectomy / methods. Cholecystitis / metabolism. Cholecystitis / pathology. Female. Gallbladder / metabolism. Gallbladder / pathology. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Proportional Hazards Models. Survival Rate

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21122411.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / ANXA2 protein, human; 0 / Annexin A1; 0 / Annexin A2
  •  go-up   go-down


61. Chakravarty KD, Yeh CN, Jan YY, Chen MF: Factors influencing long-term survival in patients with T3 gallbladder adenocarcinoma. Digestion; 2009;79(3):151-7
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors influencing long-term survival in patients with T3 gallbladder adenocarcinoma.
  • PURPOSE: This study aimed to identify the factors influencing the surgical outcome in patients with T3 gallbladder adenocarcinoma (GBA).
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Gallbladder Neoplasms / pathology. Gallbladder Neoplasms / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19329854.001).
  • [ISSN] 1421-9867
  • [Journal-full-title] Digestion
  • [ISO-abbreviation] Digestion
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen
  •  go-up   go-down


62. Wang J, Zhang M, Zhang L, Cai H, Zhou S, Zhang J, Wang Y: Correlation of Nrf2, HO-1, and MRP3 in gallbladder cancer and their relationships to clinicopathologic features and survival. J Surg Res; 2010 Nov;164(1):e99-105
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation of Nrf2, HO-1, and MRP3 in gallbladder cancer and their relationships to clinicopathologic features and survival.
  • BACKGROUND: Gallbladder cancer (GC) is considered a relatively rare malignancy with extensively poor prognosis.
  • MATERIAL AND METHODS: We immunohistochemically investigated 59 specimens of gallbladder adenocarcinoma tissues using Nrf2, HO-1, and MRP3 antibodies.
  • [MeSH-major] Adenocarcinoma / mortality. Biomarkers, Tumor / metabolism. Gallbladder Neoplasms / mortality. Heme Oxygenase-1 / metabolism. NF-E2-Related Factor 2 / metabolism. P-Glycoproteins / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20828733.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / NF-E2-Related Factor 2; 0 / NFE2L2 protein, human; 0 / P-Glycoproteins; 0 / multidrug resistance protein 3; EC 1.14.99.3 / HMOX1 protein, human; EC 1.14.99.3 / Heme Oxygenase-1
  •  go-up   go-down


63. Kirimlioğlu H, Türkmen I, Başsüllü N, Dirican A, Karadağ N, Kirimlioğlu V: The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis. Turk J Gastroenterol; 2009 Mar;20(1):41-7
MedlinePlus Health Information. consumer health - Bile Duct Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis.
  • Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumor, middle and distal extrahepatic tumors), gallbladder adenocarcinoma, and ampullary carcinoma.
  • METHODS: Ten gallbladder adenocarcinoma, 8 distal bile duct carcinomas (distal cholangiocarcinoma), 8 Klatskin tumors, 8 intrahepatic cholangiocarcinomas and 10 ampullary carcinomas were included in the study.
  • RESULTS: The nontumoral epithelia of the gallbladder, intrahepatic ducts, and Klatskin tumor did not express MMP-2.
  • The metaplastic and dysplastic epithelia were positively stained in all of the gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary tumors.
  • The gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary carcinomas expressed MMP-2 in 30%, 37% and 40% of the cases, respectively.
  • CONCLUSIONS: When tumors of the biliary system are divided as intrahepatic and extrahepatic cholangiocarcinomas, MMP-2 expression was present in the extrahepatic cholangiocarcinomas including gallbladder carcinomas.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Ampulla of Vater / enzymology. Ampulla of Vater / pathology. Disease Progression. Gallbladder Neoplasms / metabolism. Gallbladder Neoplasms / pathology. Hepatic Duct, Common / enzymology. Hepatic Duct, Common / pathology. Humans. Immunohistochemistry. Klatskin Tumor / metabolism. Klatskin Tumor / pathology. Matrix Metalloproteinase 14 / metabolism. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Neoplasm Invasiveness. Prognosis

  • Genetic Alliance. consumer health - Intrahepatic cholangiocarcinoma.
  • Genetic Alliance. consumer health - Klatskin tumor.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19330734.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.80 / Matrix Metalloproteinase 14
  •  go-up   go-down


64. Olivas Mendoza G, Mesina Sandoval J, Mata Orozco VM, Hernández M: [Complicated pregnancy with lithiasis and resectable gallbladder cancer. A case report and literature review]. Ginecol Obstet Mex; 2005 Dec;73(12):661-5
MedlinePlus Health Information. consumer health - Tumors and Pregnancy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Complicated pregnancy with lithiasis and resectable gallbladder cancer. A case report and literature review].
  • [Transliterated title] Embarazo con litiasis y cáncer vesicular resecable. Comunicación de un caso clínico y revisión bibliográfica.
  • Pregnancy complicated with gallbladder disease stone has an incidence of 2-14%, and more than 30% of patients do not respond to medical treatment; therefore, in order to reduce the morbidity and mortality in fetus and mother, surgical management would be required.
  • The current use of ultrasound of high resolution has facilitated the diagnosis and also, in the present clinical case, this imaging modality allowed us to suspect the unusual diagnosis reported, that corresponds to a female of 34 years old with 33 weeks of pregnancy, complicated with symptomatic gallbladder disease stone, whose pain was intractable at the expectant management.
  • The clinical diagnosis was corroborated by ultrasound and the report was: lithiasis, biliary sludge and an intragallbladder image of bilobular polypoid.
  • The patient was submitted to cholecystectomy by laparotomy, whose histopathologic findings were: cholelithiasis and in situ gallbladder adenocarcinoma with an exophytic growing variety.
  • [MeSH-major] Adenocarcinoma. Adenomatous Polyps. Carcinoma in Situ. Cholelithiasis. Gallbladder Neoplasms. Pregnancy Complications. Pregnancy Complications, Neoplastic


65. Wu Q, Kiguchi K, Kawamoto T, Ajiki T, Traag J, Carbajal S, Ruffino L, Thames H, Wistuba I, Thomas M, Vasquez KM, DiGiovanni J: Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model. Cancer Res; 2007 Apr 15;67(8):3794-800
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model.
  • In this study, we used BK5.erbB2 transgenic mice as an animal model to examine the therapeutic effect of rapamycin as a potential treatment for gallbladder cancer.
  • Homozygous BK5.erbB2 mice overexpressing the wild-type rat erbB2 gene in basal epithelial cells of the gallbladder have an approximately 70% incidence of gallbladder adenocarcinoma by 2 to 3 months of age.
  • Rapamycin significantly reduced the incidence and severity of gallbladder carcinoma in BK5.erbB2 mice in a dose-dependent manner.
  • Furthermore, rapamycin treatment led to decreased levels of phosphorylated p70 S6 kinase (Thr(389)) in gallbladder tissue as assessed by both Western blot and immunofluorescence analyses.
  • Finally, immunofluorescence staining revealed elevated phosphorylated Akt (Ser(473)) and phosphorylated mammalian target of rapamycin (mTOR; Ser(2448)) in human gallbladder cancer compared with normal gallbladder tissue.
  • Based on our results using a novel genetically engineered mouse model and the fact that the Akt/mTOR pathway is activated in human gallbladder cancer, rapamycin and related drugs may be effective therapeutic agents for the treatment of human gallbladder cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antibiotics, Antineoplastic / pharmacology. Gallbladder Neoplasms / drug therapy. Sirolimus / pharmacology

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. SIROLIMUS .
  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17440093.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 099526; United States / NCI NIH HHS / CA / CA 16672
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; EC 2.7.1.1 / mTOR protein, rat; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 70-kDa; W36ZG6FT64 / Sirolimus
  •  go-up   go-down


66. Park JS, Jung WH, Kim JK, Hwang HK, Cho SI, Yoon DS, Chi HS, Kim BR: Estrogen receptor alpha, estrogen receptor beta, and progesterone receptor as possible prognostic factor in radically resected gallbladder carcinoma. J Surg Res; 2009 Mar;152(1):104-10
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Estrogen receptor alpha, estrogen receptor beta, and progesterone receptor as possible prognostic factor in radically resected gallbladder carcinoma.
  • BACKGROUND: Gallbladder carcinoma is a relatively rare malignancy with a poor prognosis.
  • Gallbladder carcinoma occurs more frequently in women than men, yet expression of the estrogen receptor (ER) and progesterone (PR) have not been studied.
  • We applied an immunohistochemical stain to examine the expression of ER(alpha), ER(beta), and PR in radically resected gallbladder carcinoma.
  • MATERIAL AND METHODS: We immunohistochemically investigated 30 specimens of gallbladder adenocarcinoma tissues using ER(alpha), ER(beta), and PR antibodies.
  • RESULTS: Adenocarcinoma of gallbladder is negative for both ER(alpha) and PR.
  • CONCLUSIONS: Evaluation of ER(beta) expression in gallbladder carcinoma may be an important factor in identifying a poor prognostic group of gallbladder carcinoma.
  • [MeSH-major] Carcinoma / metabolism. Estrogen Receptor alpha / metabolism. Estrogen Receptor beta / metabolism. Gallbladder Neoplasms / metabolism. Receptors, Progesterone / metabolism
  • [MeSH-minor] Aged. Female. Gallbladder / pathology. Humans. Male. Middle Aged. Prognosis. Republic of Korea / epidemiology. Survival Analysis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18394649.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Receptors, Progesterone
  •  go-up   go-down


67. Pavić I, Marusić Z, Mijić A, Balicević D, Kruslin B, Tomas D: A case of signet-ring cell carcinoma of the gallbladder: immunohistochemistry and differential diagnosis. Acta Clin Croat; 2010 Jun;49(2):159-62
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of signet-ring cell carcinoma of the gallbladder: immunohistochemistry and differential diagnosis.
  • The morphological spectrum of gallbladder carcinoma is broad and variable.
  • Most of these tumors are tubular adenocarcinomas.
  • One of such tumors is the signet-ring cell carcinoma, which is a highly aggressive, mucin producing variant of gallbladder adenocarcinoma predominantly or exclusively composed of signet-ring cells.
  • We found only three cases of signet-ring cell carcinoma of the gallbladder previously reported.
  • We present the case of an 86-year-old woman with signet-ring cell carcinoma of the gallbladder and discuss the potential diagnostic dilemmas
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry

  • Genetic Alliance. consumer health - Signet ring cell carcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21086733.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  •  go-up   go-down


68. Li Q, Yang Z: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations. J Exp Clin Cancer Res; 2009;28:65
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.
  • However, few studies have examined gallbladder cancer specimens, and little is known about the clinical and pathological significance of ERK1/2 and PI3-K/AKT signaling changes in gallbladder adenocarcinoma.
  • In this study, we examined phospho-ERK1/2 (p-ERK1/2) and PI3K expression and analyzed its clinicopathological impact in gallbladder adenocarcinoma.
  • METHODS: Immunohistochemistry was used to detect and compare the frequency of p-ERK1/2 and PI3-K expression in gallbladder adenocarcinoma, peri-tumor tissues, adenomatous polyps, and chronic cholecystitis specimens.
  • RESULTS: The positive staining for p-EKR1/2 and PI3-K were 63/108 (58.3%) and 55/108 (50.9%) in gallbladder adenocarcinoma; 14/46 (30.4%) and 5/46 (10.1%) in peri-tumor tissues; 3/15 (20%) and 3/15 (20%) in adenomatous polyps; and 4/35 (11.4%) and 3/35 (8.6%) in chronic cholecystitis.
  • The positive rate of p-ERK1/2 or PI3-K in gallbladder adenocarcinoma was significantly higher than that in peri-tumor tissue (both, P < 0.01), adenomatous polyps (p-ERK1/2, P < 0.01; PI3-K, P < 0.05), and chronic cholecystitis (both, P < 0.01).
  • The positive staining for p-ERK1/2 or PI3-K was significantly lower in well/highly-differentiated adenocarcinomas with maximal diameter < 2.0 cm, no metastasis to lymph node, and no infiltration of regional tissues or organs compared to poorly-differentiated adenocarcinomas which are characterized by a maximal diameter >or= 2.0 cm, with metastasis to lymph node and infiltration of regional tissues or organs (P < 0.05 or P < 0.01).
  • Moreover, the frequency of p-ERK1/2 expression in gallbladder adenocarcinomas without gallstone was significantly lower than those with gallstones.
  • Multivariate Cox regression analysis showed that increased p-ERK1/2 expression was an independent prognostic predictor in gallbladder carcinoma (P = 0.028).
  • CONCLUSION: Increased expression of p-ERK1/2 and PI3K might contribute to gallbladder carcinogenesis. p-ERK1/2 over-expression is correlated with decreased survival and therefore may serve as an important biological marker in development of gallbladder adenocarcinoma.
  • [MeSH-major] Gallbladder Neoplasms / metabolism. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / metabolism. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma / metabolism. Adenoma / pathology. Adenomatous Polyps / metabolism. Adenomatous Polyps / pathology. Adult. Female. Gallbladder / metabolism. Gallbladder / pathology. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Staging. Phosphorylation. Prognosis. Survival Rate

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Hepatology. 1999 Nov;30(5):1128-33 [10534331.001]
  • [Cites] Int J Med Sci. 2008;5(5):285-91 [18825277.001]
  • [Cites] Ai Zheng. 2003 Mar;22(3):262-5 [12654182.001]
  • [Cites] Gut. 2003 May;52(5):706-12 [12692057.001]
  • [Cites] BMC Gastroenterol. 2003 Aug 8;3:19 [12906713.001]
  • [Cites] Nat Rev Cancer. 2004 Sep;4(9):695-706 [15343276.001]
  • [Cites] Surg Clin North Am. 1990 Dec;70(6):1419-28 [2247823.001]
  • [Cites] Cell. 1991 May 17;65(4):691-9 [1827756.001]
  • [Cites] Nature. 1991 Oct 17;353(6345):670-4 [1922387.001]
  • [Cites] Cancer. 1995 Jan 1;75(1 Suppl):171-90 [8000995.001]
  • [Cites] Pathol Res Pract. 1995 Nov;191(11):1087-91 [8822109.001]
  • [Cites] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8773-8 [9671754.001]
  • [Cites] Nat Rev Cancer. 2004 Dec;4(12):937-47 [15573115.001]
  • [Cites] Nat Rev Cancer. 2005 May;5(5):341-54 [15864276.001]
  • [Cites] Gastroenterology. 2005 Jun;128(7):2054-65 [15940637.001]
  • [Cites] Hepatology. 2005 Dec;42(6):1329-38 [16317687.001]
  • [Cites] Clin Cancer Res. 2006 Mar 15;12(6):1680-5 [16551849.001]
  • [Cites] J Gastroenterol Hepatol. 2006 Nov;21(11):1744-51 [16984600.001]
  • [Cites] J Cancer Res Clin Oncol. 2006 Dec;132(12):805-10 [16794828.001]
  • [Cites] Cancer Res. 2007 Apr 15;67(8):3794-800 [17440093.001]
  • [Cites] J Gastroenterol. 2007 Jul;42(7):567-72 [17653653.001]
  • [Cites] Br J Cancer. 2007 Dec 3;97(11):1577-82 [18000509.001]
  • [Cites] J Hepatol. 2008 Jan;48(1):83-90 [17998146.001]
  • [Cites] World J Gastroenterol. 2007 Dec 28;13(48):6470-7 [18161916.001]
  • [Cites] Pathol Res Pract. 2001;197(2):95-100 [11261824.001]
  • (PMID = 19445727.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3
  • [Other-IDs] NLM/ PMC2691734
  •  go-up   go-down


69. Kim H, Song JY, Cho JY, Yoon YS, Han HS, Lee HS, Ryu HS, Choe G: Strong cytoplasmic expression of COX2 at the invasive fronts of gallbladder cancer is associated with a poor prognosis. J Clin Pathol; 2010 Dec;63(12):1048-53
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Strong cytoplasmic expression of COX2 at the invasive fronts of gallbladder cancer is associated with a poor prognosis.
  • AIM: The significance of cell cycle proteins, p21 and p53, and cyclo-oxygenase-2 (COX2) is still controversial in gallbladder adenocarcinoma.
  • Conflicting results exist with regard to the prognostic significance of p21 and p53 expression, and the strong association of gallbladder cancer with chronic inflammation makes it only natural that COX2 negativity is rarely encountered, even in non-neoplastic biliary epithelia.
  • METHODS: The authors explored whether the p21 and p53-labelling indices (LI) and strong cytoplasmic COX2 expression differ in the central parts (TC) and invasive fronts (IF) of gallbladder cancer.
  • Paraffin-embedded whole tissue sections of 67 gallbladder cancers were immunohistochemically analysed for p21, p53 and COX2-LI at the IF and TC, and results were correlated with the clinicopathological features.
  • CONCLUSIONS: The IF of gallbladder cancer is characterised by significantly increased expression of p21, p53 and strong COX2 expression, and strong cytoplasmic COX2 expression at IF is associated with a poorer prognosis.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Cyclooxygenase 2 / metabolism. Gallbladder Neoplasms / metabolism

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20924037.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Protein p53; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
  •  go-up   go-down


70. Makiyama A, Qin B, Uchino K, Shibata Y, Arita S, Isobe T, Hirano G, Kusaba H, Baba E, Akashi K, Nakano S: Schedule-dependent synergistic interaction between gemcitabine and oxaliplatin in human gallbladder adenocarcinoma cell lines. Anticancer Drugs; 2009 Feb;20(2):123-30
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schedule-dependent synergistic interaction between gemcitabine and oxaliplatin in human gallbladder adenocarcinoma cell lines.
  • To define the most effective combination schedule of gemcitabine and oxaliplatin (L-OHP), we investigated the in-vitro interaction between these drugs in a panel of four human gallbladder adenocarcinoma cell lines (HAG-1, GB-d1, NOZ, and G-415).
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / pharmacology. Deoxycytidine / analogs & derivatives. Gallbladder Neoplasms / drug therapy. Organoplatinum Compounds / pharmacology

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19209029.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
  •  go-up   go-down


71. Kiguchi K, Ruffino L, Kawamoto T, Franco E, Kurakata S, Fujiwara K, Hanai M, Rumi M, DiGiovanni J: Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice. Mol Cancer Ther; 2007 Jun;6(6):1709-17
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice.
  • Biliary tract cancer is still challenging to treat and manage due to its poor sensitivity to conventional therapies and the inability to prevent or detect the early tumor formation.
  • The most well known risk factor for gallbladder cancer is the presence of chronic inflammation, usually related to gallstones.
  • Homozygous BK5.ErbB-2 mice develop adenocarcinoma of gallbladder with an approximately 90% incidence.
  • In addition to the activation of ErbB-2 and epidermal growth factor receptor, mRNA and protein levels of COX-2 were up-regulated in the gallbladder carcinomas that developed in these transgenic mice.
  • The aim of this study was to examine the effects of a COX-2 inhibitor, CS-706, on the development of gallbladder carcinomas using the BK5.ErbB-2 mouse model.
  • Ultrasound image analysis as well as histologic evaluation revealed a significant therapeutic effect of CS-706 on the gallbladder tumors, either as reversion to a milder phenotype or inhibition of tumor progression.
  • CS-706 treatment also down-regulated the activation of ErbB-2 and epidermal growth factor receptor, resulting in decreased levels of phosphorylated Akt and COX-2 in gallbladder cancers of BK5.ErbB-2 mice.
  • Based on our results, targeting COX-2 could provide a potentially new and effective therapy alone or in combination with other therapeutic agents for patients with biliary tract cancer.
  • [MeSH-major] Cyclooxygenase Inhibitors / therapeutic use. Gallbladder Neoplasms / drug therapy. Pyrroles / therapeutic use. Sulfonamides / therapeutic use

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • COS Scholar Universe. author profiles.
  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17575102.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA16672; United States / PHS HHS / / R01 102575; United States / NCI NIH HHS / CA / R01 CA99526
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors; 0 / Pyrroles; 0 / Sulfonamides; 5X5HB3VZ3Z / apricoxib; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2; K7Q1JQR04M / Dinoprostone
  •  go-up   go-down


72. del Pozo AC, De Battista S, Velasco D, Pianzola H, Rodríguez J: [Epidermoid carcinoma of gallbladder: analysis of our casuistic]. Acta Gastroenterol Latinoam; 2005;35(3):162-4
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Epidermoid carcinoma of gallbladder: analysis of our casuistic].
  • [Transliterated title] Carcinoma epidermoide de vesícula: análisis de nuestra casuística.
  • BACKGROUND: The most common type of gallbladder cancer is the adenocarcinoma.
  • The squamous cell carcinoma represents only a 0-12% of all gallbladder tumors.
  • METHODS: 124 cases of malignant neoplasias of the gallbladder were diagnosed during the last 33 years in the Department of Surgery of our hospital.
  • Liver involvement was observed in 4 of 5 patients at the moment of diagnosis.
  • CONCLUSION: The tumor extention at the time of diagnosis is generally advanced and the outcome is not promising in this kind of gallbladder cancer.
  • [MeSH-major] Carcinoma, Squamous Cell. Gallbladder Neoplasms

  • Genetic Alliance. consumer health - Epidermoid Carcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16333974.001).
  • [ISSN] 0300-9033
  • [Journal-full-title] Acta gastroenterologica Latinoamericana
  • [ISO-abbreviation] Acta Gastroenterol. Latinoam.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Argentina
  •  go-up   go-down


73. Akatsu T, Aiura K, Shimazu M, Ueda M, Wakabayashi G, Tanabe M, Kawachi S, Kitajima M: Can endoscopic ultrasonography differentiate nonneoplastic from neoplastic gallbladder polyps? Dig Dis Sci; 2006 Feb;51(2):416-21
MedlinePlus Health Information. consumer health - Gallbladder Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can endoscopic ultrasonography differentiate nonneoplastic from neoplastic gallbladder polyps?
  • The present study aimed to clarify the endoscopic ultrasonography (EUS) features of nonneoplastic (cholesterol polyps and adenomyomatosis) and neoplastic (adenoma and adenocarcinoma) gallbladder polyps and to evaluate the effectiveness and limitation of EUS in the differential diagnosis of these lesions.
  • We retrospectively compared EUS images with histologic findings in 29 surgical cases with gallbladder polyps with a diameter of 10 to 20 mm.
  • However, three of nine neoplastic lesions (three adenomas and six adenocarcinomas) showed one of these signs due to concomitant cholesterosis (n = 2) or proliferated Rokitansky-Aschoff sinuses (n = 1).
  • In conclusion, 69% (20/29) of gallbladder polyps larger than 10 mm that were preoperatively suspected of malignancy were nonneoplastic.
  • [MeSH-major] Adenocarcinoma / diagnostic imaging. Adenoma / diagnostic imaging. Endosonography. Gallbladder Diseases / diagnostic imaging. Gallbladder Neoplasms / diagnostic imaging. Polyps / diagnostic imaging
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Br J Surg. 1985 Sep;72(9):728-30 [3899247.001]
  • [Cites] J Gastroenterol. 1996 Jun;31(3):470-4 [8726845.001]
  • [Cites] Br J Surg. 2000 Apr;87(4):414-7 [10759734.001]
  • [Cites] Br J Surg. 1992 Mar;79(3):227-9 [1555088.001]
  • [Cites] Am J Gastroenterol. 1988 Jun;83(6):670-4 [3376922.001]
  • [Cites] Cancer. 1982 Nov 15;50(10):2226-34 [7127263.001]
  • [Cites] Lancet. 1997 Mar 22;349(9055):817 [9121250.001]
  • [Cites] Surgery. 1991 Jan;109(1):107-10 [1984629.001]
  • [Cites] Am J Surg. 2001 Jan;181(1):65-70 [11248179.001]
  • [Cites] Am J Gastroenterol. 1989 Nov;84(11):1386-90 [2683741.001]
  • [Cites] Br J Surg. 1990 Apr;77(4):363-4 [2187556.001]
  • [Cites] World J Surg. 1999 Jul;23 (7):708-12 [10390591.001]
  • [Cites] Gastroenterol Jpn. 1981;16(2):134-40 [7227765.001]
  • [Cites] Am J Gastroenterol. 1992 May;87(5):630-3 [1595653.001]
  • [Cites] Ann Surg. 2001 Nov;234(5):657-60 [11685029.001]
  • [Cites] Scand J Gastroenterol. 1990 Mar;25(3):281-6 [2320947.001]
  • [Cites] Endoscopy. 2002 Dec;34(12 ):959-65 [12471539.001]
  • [Cites] Arch Surg. 1988 Jan;123(1):26-9 [3276295.001]
  • [Cites] Arch Pathol. 1970 Nov;90(5):423-32 [4319984.001]
  • [Cites] Gastrointest Endosc. 2000 Sep;52(3):372-9 [10968853.001]
  • [Cites] Gut. 1996 Dec;39(6):860-2 [9038670.001]
  • [Cites] Am J Gastroenterol. 1997 Nov;92 (11):2066-8 [9362194.001]
  • [Cites] Acta Pathol Jpn. 1993 Jan-Feb;43(1-2):82-5 [8465661.001]
  • [Cites] Am J Gastroenterol. 1986 Jan;81(1):61-6 [3942125.001]
  • (PMID = 16534690.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


74. Qin B, Ariyama H, Baba E, Tanaka R, Kusaba H, Harada M, Nakano S: Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells. Cancer Chemother Pharmacol; 2006 Nov;58(5):577-84
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells.
  • METHODS: Using parental and v-src- or c-H-ras-transfected HAG-1 human gallbladder adenocarcinoma cell lines, effects of gefitinib on cytotoxicity, cell cycle purtubation and apoptosis, and tyrosine phosphorylation of EGFR, Akt, and Erk were determined by WST-1 assay, flow cytometry, and Western blots, respectively.
  • [MeSH-minor] Antineoplastic Agents / pharmacology. Apoptosis / drug effects. Benzoquinones / pharmacology. Blotting, Western. Cell Cycle / drug effects. Cell Line, Tumor. Cell Survival / drug effects. Drug Resistance, Neoplasm. Extracellular Signal-Regulated MAP Kinases / metabolism. Flow Cytometry. Gallbladder / metabolism. Gallbladder / pathology. Humans. Inhibitory Concentration 50. Lactams, Macrocyclic / pharmacology. Phosphorylation / drug effects. Protein Kinase Inhibitors / pharmacology. Proto-Oncogene Proteins c-akt / metabolism. Rifabutin / analogs & derivatives. Tyrosine / metabolism

  • Hazardous Substances Data Bank. L-TYROSINE .
  • Hazardous Substances Data Bank. RIFABUTIN .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16532343.001).
  • [ISSN] 0344-5704
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzoquinones; 0 / Lactams, Macrocyclic; 0 / Protein Kinase Inhibitors; 0 / Quinazolines; 1W306TDA6S / Rifabutin; 42HK56048U / Tyrosine; 70563-58-5 / herbimycin; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.2 / Proto-Oncogene Proteins pp60(c-src); EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; S65743JHBS / gefitinib
  •  go-up   go-down


75. Orts JA, Morell L, Camps J, Traba ML, Belenguer A, Guerrero A: [Multiple enterolithiasis, coexisting with bladder and gallbladder lithiasis, associated with colon adenocarcinoma]. An Med Interna; 2005 May;22(5):227-30
Hazardous Substances Data Bank. PHOSPHORUS, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multiple enterolithiasis, coexisting with bladder and gallbladder lithiasis, associated with colon adenocarcinoma].
  • [Transliterated title] Enterolitiasis múltiple, coexistiendo con litiasis biliar y vesical, asociada a adenocarcinoma de colon.
  • We report a case of multiple enterolithiasis, very infrequent pathology, coexisting with bladder and gall bladder lithiasis in a patient with colon adenocarcinoma.
  • Diagnosis was made by X-rays and CT images.
  • No risk factors for lithogenesis were found in this patient excluding the intestinal stasis caused by intestinal narrowing as a result of adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Calculi / complications. Cholelithiasis / complications. Colonic Neoplasms / complications. Intestinal Diseases / complications. Urinary Bladder Calculi / complications

  • MedlinePlus Health Information. consumer health - Gallstones.
  • Hazardous Substances Data Bank. MAGNESIUM, ELEMENTAL .
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16001938.001).
  • [ISSN] 0212-7199
  • [Journal-full-title] Anales de medicina interna (Madrid, Spain : 1984)
  • [ISO-abbreviation] An Med Interna
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 27YLU75U4W / Phosphorus; I38ZP9992A / Magnesium; SY7Q814VUP / Calcium
  •  go-up   go-down


76. Alberts SR, Al-Khatib H, Mahoney MR, Burgart L, Cera PJ, Flynn PJ, Finch TR, Levitt R, Windschitl HE, Knost JA, Tschetter LK: Gemcitabine, 5-fluorouracil, and leucovorin in advanced biliary tract and gallbladder carcinoma: a North Central Cancer Treatment Group phase II trial. Cancer; 2005 Jan 1;103(1):111-8
Hazardous Substances Data Bank. LEUCOVORIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gemcitabine, 5-fluorouracil, and leucovorin in advanced biliary tract and gallbladder carcinoma: a North Central Cancer Treatment Group phase II trial.
  • The authors evaluated 6-month survival, response, and toxicity associated with a combination of gemcitabine, 5-fluorouracil (5-FU), and leucovorin (LV) in patients with unresectable or metastatic biliary tract or gallbladder adenocarcinoma (ACA).
  • CONCLUSIONS: This combination regimen was manageable in patients with advanced biliary tract and gallbladder ACA.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biliary Tract Neoplasms / drug therapy. Cholangiocarcinoma / drug therapy. Deoxycytidine / analogs & derivatives. Gallbladder Neoplasms / drug therapy

  • Genetic Alliance. consumer health - Biliary Tract Cancer.
  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • COS Scholar Universe. author profiles.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • Hazardous Substances Data Bank. FLUOROURACIL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15558814.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-15083; United States / NCI NIH HHS / CA / CA-25224; United States / NCI NIH HHS / CA / CA-35101; United States / NCI NIH HHS / CA / CA-35103; United States / NCI NIH HHS / CA / CA-35195; United States / NCI NIH HHS / CA / CA-35415; United States / NCI NIH HHS / CA / CA-35448; United States / NCI NIH HHS / CA / CA-37404; United States / NCI NIH HHS / CA / CA-37417; United States / NCI NIH HHS / CA / CA-52352; United States / NCI NIH HHS / CA / CA-60276; United States / NCI NIH HHS / CA / CA-63826; United States / NCI NIH HHS / CA / CA-63848; United States / NCI NIH HHS / CA / CA-63849
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
  •  go-up   go-down


77. Ariyama H, Qin B, Baba E, Tanaka R, Mitsugi K, Harada M, Nakano S: Gefitinib, a selective EGFR tyrosine kinase inhibitor, induces apoptosis through activation of Bax in human gallbladder adenocarcinoma cells. J Cell Biochem; 2006 Mar 1;97(4):724-34
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gefitinib, a selective EGFR tyrosine kinase inhibitor, induces apoptosis through activation of Bax in human gallbladder adenocarcinoma cells.
  • Although gefitinib, a selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has been clinically demonstrated to be effective for certain cancer cell types, the molecular mechanisms of the anti-tumor activity have not been fully elucidated.
  • In this study, we investigated the mechanism of gefitinib-induced growth inhibition and apoptosis in HAG-1 human gallbladder adenocarcinoma cells.
  • [MeSH-major] Adenocarcinoma / metabolism. Apoptosis / drug effects. Gallbladder Neoplasms / metabolism. Quinazolines / pharmacology. Receptor, Epidermal Growth Factor / metabolism. bcl-2-Associated X Protein / metabolism

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] 2005 Wiley-Liss, Inc.
  • (PMID = 16229013.001).
  • [ISSN] 0730-2312
  • [Journal-full-title] Journal of cellular biochemistry
  • [ISO-abbreviation] J. Cell. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Cell Cycle Proteins; 0 / Protein Kinase Inhibitors; 0 / Quinazolines; 0 / bcl-2-Associated X Protein; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; S65743JHBS / gefitinib
  •  go-up   go-down


78. Arévalo F, Arias Stella C, Monge E: [Immunoexpression of p53 and cyclin D1 in adenomas of the gallbladder]. Rev Esp Enferm Dig; 2007 Dec;99(12):694-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Immunoexpression of p53 and cyclin D1 in adenomas of the gallbladder].
  • [Transliterated title] Inmunoexpresión de p53 y ciclina D1 en adenomas de vesícula biliar.
  • INTRODUCTION: Gallbladder adenomas are infrequent neoplasms whose relation to adenocarcinoma is not well understood.
  • It has been suggested that adenomas and adenocarcinomas follow different molecular pathways.
  • MATERIAL AND METHODS: This is a comparative, cross-sectional study in which we compared p53 and D1 cyclin expression in adenomas and adenocarcinomas of the gallbladder.
  • Expression of p53 occurred in 83.3% of adenocarcinomas and in 16.6% of adenomas (p = 0.003).
  • D1 cyclin was expressed in a similar number of adenomas and adenocarcinomas.
  • CONCLUSION: Our results support the hypothesis that p53 is an important step in the pathogenesis of adenocarcinomas but not of adenomas of the gallbladder.
  • [MeSH-major] Adenoma / metabolism. Cyclin D1 / biosynthesis. Gallbladder Neoplasms / metabolism. Tumor Suppressor Protein p53 / biosynthesis

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18290692.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1
  •  go-up   go-down


79. Roa JC, Roa I, Correa P, Vo Q, Araya JC, Villaseca M, Guzmán P, Schneider BG: Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder. J Gastroenterol; 2005 Jan;40(1):79-86
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder.
  • BACKGROUND: Gallbladder cancer is very common in Chile and is the leading cause of cancer deaths in women aged over 40 years.
  • Microsatellite analysis was performed using polymerase chain reaction (PCR)-based assays to identify genetic loci that were altered in neoplastic and preneoplastic conditions of early and advanced gallbladder cancer.
  • METHODS: We selected 59 surgical specimens of gallbladder adenocarcinomas (29 early cancers and 30 advanced cancers) and 22 surgical specimens from patients with chronic cholecystitis from a high-risk area for gallbladder cancer (Temuco, Chile).
  • RESULTS: We found that 10% (6/59) of gallbladder cancers showed high-frequency microsatellite instability (MSI-H), with identical proportions in both early and advanced cancers.
  • CONCLUSIONS: Microsatellite instability was observed in equal proportions in early and late cancers, and it was also found in premalignant lesions, indicating that inactivation of mismatch repair genes occurs early in gallbladder carcinogenesis.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Gallbladder Neoplasms / genetics. Gallbladder Neoplasms / pathology. Genomic Instability / genetics. Microsatellite Repeats / genetics. Precancerous Conditions / genetics. Precancerous Conditions / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15692793.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
  •  go-up   go-down


80. Ciurea S, Matei E, Petrisor P, Luca L, Boros M, Herlea V, Popescu I: Gallbladder adenoma with focal adenocarcinoma. Chirurgia (Bucur); 2008 May-Jun;103(3):355-8
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gallbladder adenoma with focal adenocarcinoma.
  • The majority of polypoid lesions of the gallbladder are cholesterolosis pseudopolyps.
  • The case of a 52-year old male patient with an adenomatous polyp of the GB with focal adenocarcinoma is presented.
  • [MeSH-major] Adenocarcinoma. Adenoma. Gallbladder Neoplasms. Neoplasms, Multiple Primary

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18717288.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  •  go-up   go-down


81. Mishra PK, Jatawa SK, Raghuram GV, Pathak N, Jain A, Tiwari A, Varshney S, Maudar KK: Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas. Genet Mol Res; 2009;8(4):1202-10
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas.
  • Gallbladder carcinoma is an uncommon, but highly malignant tumor, with poor prognostic, and diagnostic manifestations in early stages.
  • The Indian Council of Medical Research reported increased incidence of gallbladder carcinoma in the surviving population of the Bhopal gas tragedy that involved exposure of more than 500,000 people to methyl isocyanate gas.
  • The severity of exposure, and increased multi-systemic morbidity in the survivors stimulated us to examine the molecular changes leading to gallbladder carcinoma.
  • Surgically resected samples (N = 40) of gallbladder carcinoma were studied for the p53, Rad50, and cyclin-E expression by immunohistofluorescence bioimaging.
  • Among the 40 samples, 23, 11, and 10 showed p53, Rad50, and cyclin-E expression, respectively, in moderately differentiated adenocarcinomas, demonstrating the prevalence and invasiveness of this disease in the methyl isocyanate-exposed population (P = 0.0009).
  • We conclude that there was altered expression of p53, Rad50, and cyclin-E in the malignant transformation of gallbladder carcinoma in this methyl isocyanate gas-exposed cohort.
  • Hence, these proteins may be useful as markers to identify premalignant lesions that are likely to progress into malignant adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Cyclin E / metabolism. DNA Repair Enzymes / metabolism. DNA-Binding Proteins / metabolism. Gallbladder Neoplasms / metabolism. Microsatellite Repeats / genetics. Tumor Suppressor Protein p53 / metabolism

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19866438.001).
  • [ISSN] 1676-5680
  • [Journal-full-title] Genetics and molecular research : GMR
  • [ISO-abbreviation] Genet. Mol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Cyclin E; 0 / DNA-Binding Proteins; 0 / Rad50 protein, human; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 6.5.1.- / DNA Repair Enzymes
  •  go-up   go-down


82. Brevet M, Brehant O, Dumont F, Regimbeau JM, Dupas JL, Chatelain D: [Adenomatous polyposis of the gallbladder and Gardner's syndrome. A rare association]. Gastroenterol Clin Biol; 2007 Apr;31(4):425-7
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatous polyposis of the gallbladder and Gardner's syndrome. A rare association].
  • [Transliterated title] Polypose adénomateuse vésiculaire et syndrome de Gardner: une association rare.
  • We report one case of adenomatous polyposis of the gallbladder in a 57 year-old woman with Gardner's syndrome presenting with cholangitis.
  • On gross examination the gallbladder contained two calculi and numerous flat or polypoid adenomas less than 1 cm in size.
  • Only 10 cases of gallbladder adenomas have been reported in the literature in patients presenting with familial adenomatous polyposis (FAP).
  • These adenomatous gallbladder lesions are discovered late, often when the patient is older than 40.
  • Pathogenesis of gallbladder adenomas is still unclear.
  • It is difficult to assess the risk of malignancy: only 6 cases of gallbladder adenocarcinomas have been reported in patients with FAP.
  • [MeSH-major] Adenomatous Polyps / complications. Gallbladder Neoplasms / complications. Gardner Syndrome / complications
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Age Factors. Aged. Cholecystectomy. Female. Follow-Up Studies. Gallbladder / pathology. Humans. Male. Middle Aged. Time Factors

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17483782.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
  •  go-up   go-down


83. Luzar B, Poljak M, Cör A, Klopcic U, Ferlan-Marolt V: Expression of human telomerase catalytic protein in gallbladder carcinogenesis. J Clin Pathol; 2005 Aug;58(8):820-5
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of human telomerase catalytic protein in gallbladder carcinogenesis.
  • AIMS: To determine the potential role of hTERT protein in gallbladder carcinogenesis.
  • MATERIAL/METHODS: hTERT protein was analysed by means of immunohistochemistry in 89 gallbladder tissue samples: 16 normal epithelia, 14 reactive hyperplasias, 15 low grade dysplasias, 16 high grade dysplasias, and 28 adenocarcinomas.
  • RESULTS: The mean hTERT index increased progressively with the degree of gallbladder epithelial abnormalities: from 0.03 in normal epithelia, 0.04 in hyperplastic epithelia, 0.25 in low grade dysplasia, 0.82 in high grade dysplasia, to 0.93 in adenocarcinoma.
  • Statistical analysis revealed that three different groups of gallbladder epithelial changes can be distinguished according to the number of hTERT signals for each nucleus:.
  • (1) normal and regenerative gallbladder epithelium, (2) low grade dysplasia, and (3) high grade dysplasia and adenocarcinoma (p < 0.001).
  • CONCLUSIONS: The occasional presence of hTERT protein in normal and regenerative gallbladder mucosa reflects their regenerative capacity.
  • Nevertheless, significantly higher hTERT indices in low and high grade dysplastic epithelia and in gallbladder adenocarcinomas are probably a consequence of hTERT re-expression--an early event in the multistep process of gallbladder carcinogenesis.
  • [MeSH-major] Cell Transformation, Neoplastic / metabolism. DNA-Binding Proteins / metabolism. Gallbladder Neoplasms / enzymology. Precancerous Conditions / enzymology. Telomerase / metabolism
  • [MeSH-minor] Adenocarcinoma / enzymology. Adenocarcinoma / pathology. Disease Progression. Humans. Immunoenzyme Techniques. Neoplasm Proteins / metabolism. Retrospective Studies

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Int J Mol Med. 2001 Mar;7(3):281-7 [11179508.001]
  • [Cites] Cell. 2001 Sep 21;106(6):661-73 [11572773.001]
  • [Cites] Int J Cancer. 2001 Mar 1;91(5):644-9 [11267974.001]
  • [Cites] Gene. 2001 May 16;269(1-2):1-12 [11376932.001]
  • [Cites] Oncogene. 2002 Jan 21;21(4):688-97 [11850797.001]
  • [Cites] Liver. 2002 Feb;22(1):57-69 [11906620.001]
  • [Cites] Nat Cell Biol. 2002 Sep;4(9):731-6 [12198499.001]
  • [Cites] Endoscopy. 2003 Feb;35(2):185-8 [12561014.001]
  • [Cites] Am J Pathol. 2003 Sep;163(3):859-67 [12937127.001]
  • [Cites] Histochem Cell Biol. 2004 May;121(5):391-7 [15138842.001]
  • [Cites] J Theor Biol. 1973 Sep 14;41(1):181-90 [4754905.001]
  • [Cites] Nature. 1990 May 31;345(6274):458-60 [2342578.001]
  • [Cites] Nature. 1991 Apr 18;350(6319):569-73 [1708110.001]
  • [Cites] Cancer Res. 1995 Jun 15;55(12):2511-5 [7780959.001]
  • [Cites] Science. 1995 Sep 1;269(5228):1236-41 [7544491.001]
  • [Cites] Gastroenterology. 1996 Jul;111(1):232-6 [8698204.001]
  • [Cites] Pathol Int. 1996 May;46(5):333-40 [8809879.001]
  • [Cites] Dev Genet. 1996;18(2):173-9 [8934879.001]
  • [Cites] Science. 1997 Aug 15;277(5328):955-9 [9252327.001]
  • [Cites] Cell. 1997 Aug 22;90(4):785-95 [9288757.001]
  • [Cites] Hum Mol Genet. 1997 Nov;6(12):2011-9 [9328464.001]
  • [Cites] Genomics. 1997 Nov 15;46(1):46-50 [9403057.001]
  • [Cites] Science. 1998 Jan 16;279(5349):349-52 [9454332.001]
  • [Cites] Oncogene. 1998 Mar 5;16(9):1217-22 [9528864.001]
  • [Cites] Hum Pathol. 1999 Jan;30(1):21-5 [9923922.001]
  • [Cites] Int J Cancer. 1999 Jan 5;80(1):60-3 [9935231.001]
  • [Cites] Cancer. 1999 May 15;85(10):2138-43 [10326691.001]
  • [Cites] Cell. 1999 May 14;97(4):503-14 [10338214.001]
  • [Cites] J Cell Physiol. 1999 Jul;180(1):10-8 [10362013.001]
  • [Cites] Mod Pathol. 1999 Aug;12(8):763-9 [10463477.001]
  • [Cites] Gut. 1999 Nov;45(5):784-90 [10517922.001]
  • [Cites] Z Laryngol Rhinol Otol. 1963 Aug;42:541-58 [14052667.001]
  • [Cites] Clin Chem. 2000 Mar;46(3):313-8 [10702516.001]
  • [Cites] Hepatology. 2000 May;31(5):1068-72 [10796881.001]
  • [Cites] Anticancer Res. 2000 Mar-Apr;20(2A):773-8 [10810353.001]
  • [Cites] Int J Cancer. 2000 Jul 15;87(2):217-20 [10861477.001]
  • [Cites] Virchows Arch. 2000 Jul;437(1):1-16 [10963374.001]
  • [Cites] Gastrointest Endosc. 2000 Sep;52(3):380-6 [10968854.001]
  • [Cites] Clin Cancer Res. 2000 Nov;6(11):4272-7 [11106243.001]
  • [Cites] J Hepatobiliary Pancreat Surg. 2000;7(6):556-67 [11180887.001]
  • (PMID = 16049283.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Neoplasm Proteins; EC 2.7.7.49 / Telomerase
  • [Other-IDs] NLM/ PMC1770891
  •  go-up   go-down


84. Giatromanolaki A, Sivridis E, Simopoulos C, Polychronidis A, Gatter KC, Harris AL, Koukourakis MI: Hypoxia inducible factors 1alpha and 2alpha are associated with VEGF expression and angiogenesis in gallbladder carcinomas. J Surg Oncol; 2006 Sep 1;94(3):242-7
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoxia inducible factors 1alpha and 2alpha are associated with VEGF expression and angiogenesis in gallbladder carcinomas.
  • AIMS: To investigate the significance of the hypoxia inducible factors HIF-1alpha and HIF-2alpha in gallbladder adenocarcinomas and their relation to angiogenesis and to the expression of VEGF, an angiogenic factor transcriptionally regulated by HIFalphas.
  • METHODS: HIF-1alpha and 2alpha expression was assessed immunohistochemically in 60 patients with early gallbladder adenocarcinomas, treated with surgery alone.
  • CONCLUSION: Hypoxia inducible factors are upregulated in a large proportion of gallbladder adenocarcinomas, a feature strongly related to increased expression of VEGF and intensified angiogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Basic Helix-Loop-Helix Transcription Factors / biosynthesis. Gallbladder Neoplasms / metabolism. Hypoxia-Inducible Factor 1, alpha Subunit / biosynthesis. Neovascularization, Pathologic / metabolism. Vascular Endothelial Growth Factor A / biosynthesis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] 2006 Wiley-Liss, Inc.
  • (PMID = 16900513.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Transcription Factors; 0 / Vascular Endothelial Growth Factor A; 0 / endothelial PAS domain-containing protein 1
  •  go-up   go-down


85. Tanaka S, Kubota D, Lee SH, Oba K, Yamamoto T, Ikebe T, Kubo S, Matsuyama M: Latent gallbladder carcinoma in a young adult patient with acute cholecystitis: report of a case. Surg Today; 2007;37(8):713-5
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Latent gallbladder carcinoma in a young adult patient with acute cholecystitis: report of a case.
  • Acute cholecystitis associated with gallbladder carcinoma is very rare in young patients (younger than 30 years of age).
  • Moreover, a definitive preoperative diagnosis is difficult.
  • Computed tomography and ultrasonography demonstrated an enlarged gallbladder with a diffuse thick wall and a 2-cm gallstone obstructing the cystic duct.
  • The preoperative diagnosis of gallstone-induced acute cholecystitis was made and an open cholecystectomy was thus performed 2 days after admission.
  • The macroscopic findings showed a necrotic enlarged gallbladder with a thick wall and a gallstone, but no intraluminal nodular lesion.
  • Histologic examinations revealed well-differentiated focal adenocarcinoma in the gallbladder mucosa, but no venous, lymphatic, or perineural invasion.
  • [MeSH-major] Cholecystitis, Acute / complications. Gallbladder Neoplasms / surgery. Gallstones / complications

  • Genetic Alliance. consumer health - Cholecystitis.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Hepatogastroenterology. 1998 Jul-Aug;45(22):921-6 [9755981.001]
  • [Cites] Eur J Pediatr Surg. 1995 Oct;5(5):313-4 [8555140.001]
  • [Cites] J Clin Ultrasound. 1994 Nov-Dec;22(9):551-5 [7806663.001]
  • [Cites] Am Surg. 1993 Jul;59(7):430-4 [8323076.001]
  • [Cites] Surg Gynecol Obstet. 1978 Dec;147(6):929-42 [362580.001]
  • [Cites] Anticancer Res. 1997 Mar-Apr;17(2B):1235-7 [9137479.001]
  • [Cites] Arch Surg. 1967 Aug;95(2):236-40 [16097292.001]
  • [Cites] Ann Surg. 1960 Feb;151:241-4 [13838180.001]
  • [Cites] Cancer. 2006 Jan 15;106(2):434-40 [16342253.001]
  • [Cites] J Assoc Physicians India. 1985 Aug;33(8):546-7 [4055687.001]
  • (PMID = 17643222.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


86. Albores-Saavedra J, Henson DE, Moran-Portela D, Lino-Silva S: Cribriform carcinoma of the gallbladder: a clinicopathologic study of 7 cases. Am J Surg Pathol; 2008 Nov;32(11):1694-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cribriform carcinoma of the gallbladder: a clinicopathologic study of 7 cases.
  • Carcinomas of the gallbladder are morphologically heterogeneous.
  • We report here the clinicopathologic features of 7 cribriform carcinomas of the gallbladder that resemble cribriform carcinomas of the breast.
  • These 7 patients were younger than those with conventional adenocarcinomas of the gallbladder (average age for males 71 y and average age for females 72 y).
  • None of the 4 cribriform carcinomas of the gallbladder tested showed immunoreactivity for estrogen and progesterone receptors.
  • Three patients with high nuclear grade cribriform carcinomas died as a result of the tumor which infiltrated the liver by direct extension; 3 patients with low nuclear grade cribriform carcinomas confined to the gallbladder wall survived 4 to 7 years after cholecystectomy and 1 patient was lost to follow-up.
  • In conclusion, this study provides support to previous observations that a small proportion of gallbladder carcinomas display an unusual but predominant cribriform pattern similar to that of some invasive breast carcinomas.
  • In contrast to mammary cribriform carcinomas, those arising in the gallbladder occur in individuals usually with gallstones, may coexist with skeletal osteosarcoma, lack estrogen and progesterone receptors, and behave aggressively like conventional adenocarcinomas of the gallbladder.
  • [MeSH-major] Adenocarcinoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18769339.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


87. Puglisi F, Capuano P, Gentile A, Lobascio P, Russo S, Martines G, Lograno G, Memeo V: Retrobulbar metastasis from gallbladder carcinoma after laparoscopic cholecystectomy. A case report. Tumori; 2005 Sep-Oct;91(5):428-31
MedlinePlus Health Information. consumer health - Gallstones.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retrobulbar metastasis from gallbladder carcinoma after laparoscopic cholecystectomy. A case report.
  • Extra-abdominal metastases from gallbladder cancer are very rare; the sites outside the abdomen most frequently affected are the skin, bone and central nervous system.
  • In the literature, only one case of orbital metastasis from gallbladder cancer has been reported, in a patient previously treated by open cholecystectomy.
  • We report the case of a 53-year-old woman who underwent a laparoscopic cholecystectomy for symptomatic gallbladder stones.
  • Postoperative histological examination revealed an unsuspected gallbladder adenocarcinoma.
  • The few cases of uncommon gallbladder cancer metastases after laparoscopic cholecystectomy described in the literature are discussed, as well as the possible role of laparoscopy in the dissemination and localized seeding of malignant cells.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Cholecystectomy, Laparoscopic. Cholelithiasis / surgery. Gallbladder Neoplasms / diagnosis. Incidental Findings. Orbital Neoplasms / secondary

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16459642.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


88. Koswara T, Marwoto W, Siregar NC, Gumay S, Azis H, Abdullah M, Himawan S: Hepatoid carcinoma of the gallbladder. Acta Med Indones; 2007 Oct-Dec;39(4):179-82
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatoid carcinoma of the gallbladder.
  • Hepatoid carcinoma of the gallbladder is very rarely reported in the literature.
  • We report a case of hepatoid carcinoma of the gallbladder in a 71-year-old female who presented with abdominal pain and was first diagnosed as cholelithiasis with cholecystitis.
  • The microscopic findings of the gallbladder after cholecystectomy showed an area of tumor with polygonal cells, eosinophilic cytoplasm, distinct cell borders, round vesicular nuclei and prominent nucleoli, arranged in trabecular pattern resembling hepatocellular carcinoma intermingled with areas of adenocarcinoma or cholangiocarcinoma.
  • Based on these findings, this case was diagnosed as hepatoid carcinoma of the gallbladder with metastasis to the pancreas.
  • [MeSH-major] Carcinoma, Hepatocellular / secondary. Gallbladder Neoplasms / pathology. Pancreatic Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / secondary. Aged. Cholangiocarcinoma / secondary. Cholecystectomy. Fatal Outcome. Fatty Liver / pathology. Female. Humans. Immunohistochemistry. Necrosis. alpha-Fetoproteins / metabolism

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18046064.001).
  • [ISSN] 0125-9326
  • [Journal-full-title] Acta medica Indonesiana
  • [ISO-abbreviation] Acta Med Indones
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Indonesia
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
  •  go-up   go-down


89. Egberts JH, Schniewind B, Schafmayer C, Kruse ML, Sipos B, Fändrich F, Kalthoff H, Tepel J: Establishment of a novel orthotopic xenograft model of human gallbladder carcinoma. Clin Exp Metastasis; 2007;24(3):141-8
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishment of a novel orthotopic xenograft model of human gallbladder carcinoma.
  • OBJECTIVE: Gallbladder cancer is characterized by high morbidity and mortality.
  • We improved a murine orthotopic human xenotransplantation model by implanting human gallbladder carcinoma cells directly into the lumen of the gallbladder.
  • METHODS: Mz-ChA-1 cells were orthotopically injected into the gallbladder of Severe Combined Immune Deficiency (SCID) beige mice inducing the growth of solid tumors.
  • With this, we successfully established an orthotopic xenotransplant animal model and investigated the in vitro and in vivo effects of gemcitabine in human xenografted Mz-ChA-1 gallbladder adenocarcinoma.
  • [MeSH-major] Disease Models, Animal. Gallbladder Neoplasms / drug therapy

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Parasitol Int. 2000 Sep;49(3):239-51 [11426579.001]
  • [Cites] Int J Cancer. 1992 Sep 9;52(2):252-60 [1355757.001]
  • [Cites] Oncology. 2004;66(3):167-79 [15218306.001]
  • [Cites] Cancer Res. 1993 Jan 15;53(2):254-9 [7678071.001]
  • [Cites] J Hepatol. 1985;1(6):579-96 [4056357.001]
  • [Cites] Cancer. 2005 Jan 1;103(1):111-8 [15558814.001]
  • [Cites] Southeast Asian J Trop Med Public Health. 1995 Jun;26(2):231-9 [8629051.001]
  • [Cites] J Clin Oncol. 2001 Oct 15;19(20):4089-91 [11600613.001]
  • [Cites] Toxicol Pathol. 1996 Jan-Feb;24(1):90-9 [8839286.001]
  • [Cites] Ann Oncol. 2005;16 Suppl 2:ii93-6 [15958484.001]
  • [Cites] J Hepatol. 2002 Dec;37(6):806-13 [12445422.001]
  • [Cites] Carcinogenesis. 1993 Nov;14(11):2415-7 [8242874.001]
  • [Cites] Anticancer Res. 2006 Jan-Feb;26(1A):79-83 [16475682.001]
  • [Cites] Ann Oncol. 2001 Feb;12(2):183-6 [11300321.001]
  • [Cites] Int J Oncol. 2003 Nov;23(5):1293-300 [14532968.001]
  • [Cites] Anticancer Drugs. 2006 Aug;17(7):783-95 [16926628.001]
  • [Cites] Cancer Lett. 1998 Sep 25;131(2):185-90 [9851252.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2000 Feb 1;46(3):581-7 [10701737.001]
  • [Cites] J Natl Cancer Inst. 1985 Jul;75(1):29-35 [2989602.001]
  • [Cites] Eur J Surg Oncol. 1992 Aug;18(4):373-8 [1325925.001]
  • [Cites] J Surg Oncol. 1992 Dec;51(4):274-80 [1434661.001]
  • [Cites] Gastroenterology. 1995 Oct;109(4):1316-23 [7557101.001]
  • [Cites] Hepatology. 1998 Oct;28(4):1073-80 [9755245.001]
  • [Cites] Br J Cancer. 2002 Jul 15;87(2):187-93 [12107841.001]
  • [Cites] Br J Cancer. 2006 Jun 5;94(11):1751-8 [16736026.001]
  • [Cites] Oncogene. 1998 Dec 10;17(23):3045-54 [9881707.001]
  • [Cites] Hepatology. 2003 May;37(5):1097-104 [12717390.001]
  • [Cites] Int J Oncol. 2003 Oct;23(4):957-63 [12963974.001]
  • [Cites] Hepatology. 1999 May;29(5):1453-62 [10216129.001]
  • [Cites] J Hepatol. 1992 Jul;15(3):288-98 [1332997.001]
  • [Cites] Nat Med. 1999 Oct;5(10):1203-8 [10502827.001]
  • [Cites] Invest New Drugs. 2004 Apr;22(2):193-8 [14739669.001]
  • [Cites] Jpn J Clin Oncol. 2005 Feb;35(2):68-73 [15709089.001]
  • [Cites] Am J Physiol Gastrointest Liver Physiol. 2005 Apr;288(4):G779-86 [15528255.001]
  • [Cites] BMC Cancer. 2002 May 03;2:10 [11991810.001]
  • [Cites] Oncol Rep. 2004 Apr;11(4):803-7 [15010876.001]
  • [Cites] Cancer Chemother Pharmacol. 1989;24(3):148-54 [2544306.001]
  • [Cites] Cancer Res. 2005 Dec 15;65(24):11437-46 [16357152.001]
  • [Cites] Lancet. 2005 Oct 8;366(9493):1303-14 [16214602.001]
  • [Cites] Cancer Res. 2001 Oct 1;61(19):6971-6 [11585718.001]
  • [Cites] Eur J Cancer. 1998 Jun;34(7):977-86 [9849443.001]
  • [Cites] World J Gastroenterol. 2006 Mar 14;12(10):1583-90 [16570351.001]
  • (PMID = 17406986.001).
  • [ISSN] 0262-0898
  • [Journal-full-title] Clinical & experimental metastasis
  • [ISO-abbreviation] Clin. Exp. Metastasis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Keratin-8; 0 / Ki-67 Antigen; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
  •  go-up   go-down


90. Ojima H, Hasegawa T, Matsuno Y, Sakamoto M: Extramedullary myeloid tumour (EMMT) of the gallbladder. J Clin Pathol; 2005 Feb;58(2):211-3
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extramedullary myeloid tumour (EMMT) of the gallbladder.
  • This report describes a rare case of an extramedullary myeloid tumour (EMMT) of the gallbladder in a patient without leukaemia.
  • Abdominal computed tomography revealed a tumorous mass measuring 6.0 x 4.5 cm and involving the entire gallbladder.
  • A percutaneous needle biopsy was attempted, but because adenocarcinoma could not be completely ruled out, the use of undue force was considered dangerous.
  • Under a preoperative diagnosis of gallbladder carcinoma, a hepatopancreatoduodenectomy was performed.
  • In conclusion, a correct diagnosis of EMMT can be made using appropriate immunohistochemical staining.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis. Sarcoma, Myeloid / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Arch Pathol Lab Med. 2001 Nov;125(11):1448-52 [11698000.001]
  • [Cites] Virchows Arch. 2004 Aug;445(2):142-50 [15232741.001]
  • [Cites] Cancer. 1981 Sep 15;48(6):1426-37 [7023656.001]
  • [Cites] Histopathology. 1999 May;34(5):391-8 [10231412.001]
  • [Cites] J Clin Pathol. 1996 May;49(5):428-9 [8707964.001]
  • [Cites] Am J Surg Pathol. 1997 Oct;21(10):1156-65 [9331287.001]
  • [Cites] Clin Lab Med. 1990 Dec;10(4):889-901 [2272180.001]
  • (PMID = 15677545.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD
  • [Other-IDs] NLM/ PMC1770561
  •  go-up   go-down


91. Meyerhardt JA, Zhu AX, Stuart K, Ryan DP, Blaszkowsky L, Lehman N, Earle CC, Kulke MH, Bhargava P, Fuchs CS: Phase-II study of gemcitabine and cisplatin in patients with metastatic biliary and gallbladder cancer. Dig Dis Sci; 2008 Feb;53(2):564-70
Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase-II study of gemcitabine and cisplatin in patients with metastatic biliary and gallbladder cancer.
  • We conducted a multi-center, phase-II trial for patients with locally unresectable or metastatic bile duct or gallbladder adenocarcinomas using a modified regimen of gemcitabine and cisplatin to potentially improve tolerability.
  • We concluded that this modified regimen appeared to have comparable activity to other gemcitabine and cisplatin regimens against advanced bile duct and gallbladder cancers, but there was still moderate toxicity in this patient population.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bile Duct Neoplasms / drug therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / drug therapy. Cisplatin / administration & dosage. Deoxycytidine / analogs & derivatives. Gallbladder Neoplasms / drug therapy

  • Genetic Alliance. consumer health - Metastatic cancer.
  • MedlinePlus Health Information. consumer health - Bile Duct Cancer.
  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Clin Oncol. 2006 Jan 20;24(3):327-9 [16344312.001]
  • [Cites] Ann Oncol. 2005 Feb;16(2):279-81 [15668284.001]
  • [Cites] J Natl Cancer Inst. 2000 Feb 2;92 (3):205-16 [10655437.001]
  • [Cites] Ann Oncol. 2004 May;15(5):770-4 [15111345.001]
  • [Cites] Cancer. 2005 Jan 1;103(1):111-8 [15558814.001]
  • [Cites] Ann Oncol. 2007 Oct;18(10):1652-9 [17660491.001]
  • [Cites] J Clin Oncol. 2001 Oct 15;19(20):4089-91 [11600613.001]
  • [Cites] Cancer Chemother Pharmacol. 2006 May;57(5):647-53 [16142487.001]
  • [Cites] Cancer. 2005 Dec 15;104(12):2753-8 [16294346.001]
  • [Cites] Am J Clin Oncol. 2004 Dec;27(6):565-9 [15577433.001]
  • [Cites] Invest New Drugs. 2002 Aug;20(3):351-6 [12201499.001]
  • [Cites] Ann Oncol. 2001 Feb;12(2):183-6 [11300321.001]
  • [Cites] CA Cancer J Clin. 2006 Mar-Apr;56(2):106-30 [16514137.001]
  • [Cites] J Clin Oncol. 2005 Apr 1;23(10):2332-8 [15800324.001]
  • [Cites] Chemotherapy. 2003 Jun;49(3):154-8 [12815209.001]
  • [Cites] Ann Oncol. 2004 Mar;15(3):478-83 [14998852.001]
  • [Cites] Br J Cancer. 2004 Apr 19;90(8):1516-20 [15083178.001]
  • [Cites] Br J Cancer. 2004 May 4;90(9):1715-9 [15150619.001]
  • [Cites] Cancer. 2006 Mar 15;106(6):1339-46 [16475213.001]
  • [Cites] Clin Cancer Res. 1996 Mar;2(3):521-30 [9816199.001]
  • [Cites] Invest New Drugs. 2004 Apr;22(2):193-8 [14739669.001]
  • [Cites] Hepatogastroenterology. 2001 May-Jun;48(39):783-9 [11462924.001]
  • [Cites] Semin Oncol. 1995 Aug;22(4 Suppl 11):72-9 [7481849.001]
  • [Cites] Jpn J Clin Oncol. 2005 Feb;35(2):68-73 [15709089.001]
  • [Cites] BMC Cancer. 2005 Jun 12;5:61 [15949047.001]
  • [Cites] Oncology (Williston Park). 2003 Sep;17 (9 Suppl 8):23-6 [14569844.001]
  • [Cites] J Clin Oncol. 1997 Jun;15(6):2403-13 [9196156.001]
  • [Cites] Ann Oncol. 2004 Sep;15(9):1339-43 [15319238.001]
  • (PMID = 17597402.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
  •  go-up   go-down


92. Shukla VK, Goel S, Trigun SK, Sharma D: Electrophoretic pattern of proteins in carcinoma of the gallbladder. Eur J Cancer Prev; 2008 Feb;17(1):9-12
MedlinePlus Health Information. consumer health - Gallstones.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Electrophoretic pattern of proteins in carcinoma of the gallbladder.
  • Carcinoma of the gallbladder is a common health problem in the northern region of India and in spite of improved diagnostic techniques it is generally diagnosed at an advanced stage.
  • This study was carried out in 60 patients, 30 of whom were diagnosed with gallbladder carcinoma and 30 with cholelithiasis.
  • The results showed the mean concentration of total protein in gallbladder tissue of patients with carcinoma of the gallbladder was 51.83 +/- 3.36 mg/g tissue (45.33-57.80) and in patients with cholelithiasis it was 38.82 +/- 9.11 mg/g tissue (29.55-50.99) (P<0.001).
  • Protein electrophoresis of gallbladder tissue from the patients with carcinoma of the gallbladder showed three additional bands of protein (two protein bands were present in the region of 50-55 kDa and the third band was present in the region of 35 kDa), which were absent in the gallbladder tissue of cholelithiasis patients.
  • Mean total protein content in serum was 72.2 +/- 1.73 g/l (67.98-74.99) in patients of carcinoma of the gallbladder, whereas it was 71.01 +/- 3.4 g/l (60.00-78.99) (P>0.05) in the patients with cholelithiasis.
  • Electrophoretic analysis of serum protein revealed at least two additional protein bands in patients with carcinoma of the gallbladder as compared with electrophoretic pattern in cholelithiasis.
  • In conclusion, the presence of these new bands of protein in the gallbladder tissue and serum of the patients with carcinoma of the gallbladder indicate their role in the pathogenesis of the carcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Blood Proteins / analysis. Cholelithiasis / diagnosis. Electrophoresis, Polyacrylamide Gel. Gallbladder Neoplasms / diagnosis

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18090904.001).
  • [ISSN] 0959-8278
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Blood Proteins
  •  go-up   go-down


93. Cho A, Yamamoto H, Nagata M, Takiguchi N, Shimada H, Kainuma O, Souda H, Gunji H, Miyazaki A, Ikeda A, Matsumoto I: Total laparoscopic resection of the gallbladder together with the gallbladder bed. J Hepatobiliary Pancreat Surg; 2008;15(6):585-8
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Total laparoscopic resection of the gallbladder together with the gallbladder bed.
  • Patients with carcinoma of the gallbladder that is preoperatively diagnosed by radiology do not undergo laparoscopic resection, because such surgery is thought to worsen the prognosis of gallbladder carcinoma.
  • However, the prognosis for patients with incidental T2 gallbladder carcinoma who are treated laparoscopically is reportedly no worse than that for patients undergoing conventional surgery.
  • We successfully performed total laparoscopic resection of the gallbladder together with the gallbladder bed without any complications.
  • We believe that this procedure represents a valid therapeutic option for carefully selected patients with T2 carcinoma of the gallbladder.
  • [MeSH-major] Adenocarcinoma / surgery. Gallbladder Neoplasms / surgery. Laparoscopy / methods

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18987927.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


94. Kianmanesh R, Scaringi S, Castel B, Flamant Y, Msika S: [Precancerous lesions of the gallbladder]. J Chir (Paris); 2007 Jul-Aug;144(4):278-86
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Precancerous lesions of the gallbladder].
  • [Transliterated title] Lésions précancéreuses de la vésicule biliaire.
  • This Mini-review summarizes the epidemiology, predisposing and pre-cancerous conditions related to carcinoma of the gallbladder.
  • In 75% of cases, gallbladder cancer is a cholangiocarcinoma, usually presenting in a late and advanced stage, and it carries one of the worst prognoses of all GI malignancies.
  • Early stage disease is usually discovered incidentally by the pathologist in a gallbladder specimen removed for calculous cholecystitis.
  • Gallbladder polyps larger than 1.5 cm. (especially solitary sessile hypoechogenic polyps) are associated with a 50% risk of malignancy.
  • Choledochal cysts and other variations of the biliopancreatic junction are also associated with high risk; cancer may occur at a much younger age in these patients and in the absence of gallstones.
  • Porcelain gallbladder is a risk factor, particularly when there is calcification of the gallbladder mucosa.
  • Chronic gallbladder infection has been implicated as a risk factor for malignant degeneration.
  • Finally, cancer of both the gallbladder and the bile ducts is more frequent in patients suffering from primary biliary cirrhosis.
  • [MeSH-major] Gallbladder Neoplasms. Precancerous Conditions
  • [MeSH-minor] Adenocarcinoma / epidemiology. Age Factors. Bile Duct Neoplasms / complications. Bile Duct Neoplasms / epidemiology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / complications. Cholangiocarcinoma / epidemiology. Cholangiocarcinoma / pathology. Cholangitis, Sclerosing / complications. Cholecystitis / complications. Female. Gallbladder / pathology. Gallbladder Diseases / complications. Gallbladder Diseases / ultrasonography. Gallstones / complications. Humans. Incidence. Liver Cirrhosis, Biliary / complications. Male. Middle Aged. Neoplasm Staging. Polyps / complications. Polyps / ultrasonography. Prognosis. Risk Factors. Sex Factors. Tomography, X-Ray Computed

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [ErratumIn] J Chir (Paris). 2007 Nov-Dec;144(6):566
  • (PMID = 17925730.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 99
  •  go-up   go-down


95. Rau S, Autschbach F, Riedel HD, Konig J, Kulaksiz H, Stiehl A, Riemann JF, Rost D: Expression of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas. Eur J Clin Invest; 2008 Feb;38(2):134-42
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Cholangiocellular carcinomas and gallbladder carcinomas are highly aggressive tumours with a poor prognosis and are generally regarded as chemoresistant tumours.
  • Overexpression of ATP-binding cassette transporters of the multidrug resistance protein (MDR) and multidrug resistance-related protein (MRP) family in cancer cells is a major cause for the multidrug resistance phenotype in vitro and in vivo.
  • To further define the role of MRP family members in biliary tract cancer, we studied the expression and localization of MRP2 and MRP3 in cholangiocellular carcinomas and gallbladder carcinomas.
  • MATERIALS AND METHODS: The expression and cellular localization of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas and gallbladder carcinomas were analysed by immunohistochemistry using isoform-specific antibodies.
  • Expression of MRP isoforms was studied in vitro in Mz-ChA-1 cells derived from gallbladder adenocarcinoma by reverse transcription-polymerase chain reaction (RT-PCR), immunoblotting and immunofluorescence microscopy.
  • MRP3 was the predominant MRP isoform in gallbladder carcinomas (93%) and cholangiocellular carcinomas (57%), whereas MRP2 expression was detected in only 29% of gallbladder carcinomas and was undetectable in cholangiocellular carcinomas.
  • CONCLUSIONS: Our findings suggest that the intrinsic multidrug resistance of cholangiocellular and gallbladder carcinomas seems to be independent of MRP2 expression while the expression of MRP3 may contribute to the MDR phenotype.
  • [MeSH-major] Cholangiocarcinoma / metabolism. Drug Resistance, Multiple / genetics. Drug Resistance, Neoplasm / genetics. Gallbladder Neoplasms / metabolism. Membrane Transport Proteins / analysis. Multidrug Resistance-Associated Proteins / analysis

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18226047.001).
  • [ISSN] 1365-2362
  • [Journal-full-title] European journal of clinical investigation
  • [ISO-abbreviation] Eur. J. Clin. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Transport Proteins; 0 / Multidrug Resistance-Associated Proteins; 0 / multidrug resistance-associated protein 2; 0 / multidrug resistance-associated protein 3
  •  go-up   go-down


96. Lada PE, Taborda B, Sánchez M, Tommasino J, Rosso FF, Gramática L, Alecha Gil J, Echenique Elizondo M: [Adenosquamous and squamous carcinoma of the gallbladder]. Cir Esp; 2007 Apr;81(4):202-6
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenosquamous and squamous carcinoma of the gallbladder].
  • [Transliterated title] Carcinoma adenoescamoso y epidermoide de la vesícula biliar.
  • INTRODUCTION: Squamous and adenosquamous carcinomas of the gallbladder have poor prognosis.
  • MATERIAL AND METHOD: We performed a retrospective observational study of five patients with squamous or adenosquamous carcinoma of the gallbladder.
  • CONCLUSIONS: In both histological types of gallbladder carcinoma, treatment depends on the grade of local and regional invasion and tumor spread at diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Gallbladder Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17403356.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


97. Cho JY, Nam JS, Park MS, Yu JS, Paik YH, Lee SJ, Lee DK, Yoon DS: A Phase II study of capecitabine combined with gemcitabine in patients with advanced gallbladder carcinoma. Yonsei Med J; 2005 Aug 31;46(4):526-31
Hazardous Substances Data Bank. FLUOROURACIL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A Phase II study of capecitabine combined with gemcitabine in patients with advanced gallbladder carcinoma.
  • The authors evaluated survival, response, and toxicity associated with using a combination of capecitabine and gemcitabine to treat patients with unresectable or metastatic gallbladder adenocarcinoma (GBC).
  • Median age at the time of diagnosis was 62 years (range, 41-78 years).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Deoxycytidine / analogs & derivatives. Gallbladder Neoplasms / drug therapy

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. CAPECITABINE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Clin Oncol. 1999 Feb;17(2):585-92 [10080603.001]
  • [Cites] Eur J Cancer. 1998 Jul;34(8):1274-81 [9849491.001]
  • [Cites] Clin Cancer Res. 1999 Jul;5(7):1696-702 [10430071.001]
  • [Cites] Hepatogastroenterology. 1999 May-Jun;46(27):1639-42 [10430311.001]
  • [Cites] Int J Cancer. 1999 Sep 24;83(1):127-34 [10449619.001]
  • [Cites] Invest New Drugs. 1999;17(1):57-62 [10555123.001]
  • [Cites] Gan To Kagaku Ryoho. 2000 Jan;27(1):117-20 [10660743.001]
  • [Cites] Cancer Chemother Pharmacol. 2000;45(4):291-7 [10755317.001]
  • [Cites] Anticancer Drugs. 2000 Oct;11(9):707-8 [11129732.001]
  • [Cites] Ann Oncol. 2001 Feb;12(2):183-6 [11300321.001]
  • [Cites] J Clin Oncol. 2001 Apr 15;19(8):2282-92 [11304782.001]
  • [Cites] J Clin Oncol. 2001 Oct 15;19(20):4089-91 [11600613.001]
  • [Cites] Ann Oncol. 2001 Oct;12(10):1403-6 [11762811.001]
  • [Cites] J Clin Oncol. 2002 Apr 1;20(7):1759-66 [11919232.001]
  • [Cites] Ann Oncol. 2002 May;13(5):807 [12075753.001]
  • [Cites] Clin Cancer Res. 2003 Feb;9(2):693-702 [12576437.001]
  • [Cites] Semin Oncol. 2002 Dec;29(6 Suppl 20):40-5 [12577232.001]
  • [Cites] Am J Clin Oncol. 2003 Apr;26(2):151-4 [12714886.001]
  • [Cites] Am J Clin Oncol. 2003 Apr;26(2):174-7 [12714891.001]
  • [Cites] Ann Oncol. 2004 Mar;15(3):478-83 [14998852.001]
  • [Cites] Cancer. 2004 Aug 1;101(3):578-86 [15274071.001]
  • [Cites] Cancer. 1998 Feb 15;82(4):639-41 [9477094.001]
  • [Cites] Surg Today. 1998;28(9):923-8 [9744401.001]
  • [Cites] Cancer. 1998 Dec 1;83(11):2419-21 [9840543.001]
  • [Cites] Oncology. 1999 Apr;56(3):177-80 [10202270.001]
  • (PMID = 16127778.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; B76N6SBZ8R / gemcitabine; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2815838
  •  go-up   go-down


98. Inoue T, Shiraki K, Fuke H, Yamanaka Y, Miyashita K, Ito K, Suzuki M, Sugimoto K, Murata K, Nakano T: Cardiac metastases of gallbladder carcinoma. World J Gastroenterol; 2005 Apr 7;11(13):2048-9
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac metastases of gallbladder carcinoma.
  • This report describes the case of a 68-year-old woman diagnosed with advanced gallbladder cancer, whose autopsy revealed multiple metastases, including cardiac metastases.
  • [MeSH-major] Adenocarcinoma / secondary. Gallbladder Neoplasms / pathology. Heart Neoplasms / secondary

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15801006.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4305737
  •  go-up   go-down


99. Tan Y, Meng HP, Wang FQ, Cheng ZN, Wu Q, Wu HR: [Comparative proteomic analysis of human gallbladder carcinoma]. Zhonghua Zhong Liu Za Zhi; 2010 Jan;32(1):29-32
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Comparative proteomic analysis of human gallbladder carcinoma].
  • OBJECTIVE: To find out potential molecular targets for gallbladder carcinoma diagnosis and treatment by analyzing and comparing the proteins expressed in human gallbladder carcinoma tissue and benign gallbladder tissue.
  • METHODS: Proteomic analysis of 6 human gallbladder carcinoma tissues and 6 benign gallbladder tissues was carried out.
  • Total proteins of the carcinoma tissue and benign gallbladder tissue were separated by two-dimensional gel electrophoresis (2-DE).
  • There were forty six differentially expressed proteins in the gallbladder carcinom tissues.
  • The increased level of PEBP1 protein in gallbladder carcinoma was further confirmed by immunohistochemical analysis.
  • Those results may provide scientific foundation for screening the molecular biomarkers which can be used in diagnosis and treatment of gallbladder carcinoma, as well as to improve its prognosis and provide a new clue for carcinogenesis research of gallbladder carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Gallbladder Neoplasms / metabolism. Gene Expression Profiling. Phosphatidylethanolamine Binding Protein / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Electrophoresis, Gel, Two-Dimensional. Gallstones / diagnosis. Gallstones / metabolism. Gallstones / pathology. Humans. Immunohistochemistry. Middle Aged. Proteomics / methods. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

  • MedlinePlus Health Information. consumer health - Gallbladder Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20211063.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / PEBP1 protein, human; 0 / Phosphatidylethanolamine Binding Protein
  •  go-up   go-down


100. Puia IC, Vlad L, Iancu C, Al-Hajjar N, Pop F, Bălă O, Munteanu D: [Laparoscopic cholecystectomy for porcelain gallbladder]. Chirurgia (Bucur); 2005 Mar-Apr;100(2):187-9
MedlinePlus Health Information. consumer health - Gallbladder Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Laparoscopic cholecystectomy for porcelain gallbladder].
  • [Transliterated title] Colecistectomie laparoscopică pentru veziculă de porţelan.
  • The porcelain gallbladder is uncommon type of chronically inflamed gallbladder wall considered to be associated with a high frequency of adenocarcinoma and subsequently not suitable for a laparoscopic approach.
  • One conversion was due to an unconfirmed suspicion of gallbladder cancer and the other one to a fistula between the gallbladder and the common bile duct.
  • Patients with a preoperative diagnosis of porcelain gallbladder must not be excluded from the laparoscopic approach yet a low threshold for conversion must be maintained in those with a cancer suspicion.
  • [MeSH-major] Calcinosis / surgery. Cholecystectomy, Laparoscopic. Gallbladder Diseases / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / etiology. Adenocarcinoma / surgery. Aged. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / etiology. Gallbladder Neoplasms / surgery. Humans. Middle Aged. Retrospective Studies. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15957463.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
  •  go-up   go-down






Advertisement