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1. Mehra BR, Thawait AP, Narang RR, Gangane NM, Vyas VJ: Adenocarcinoma of the rete testis with uncommon presentation as haematocele. Singapore Med J; 2007 Dec;48(12):e311-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the rete testis with uncommon presentation as haematocele.
  • Adenocarcinoma of the rete testis was encountered in a 62-year-old man.
  • The tumour was localised in the region of the testicular hilum as a greyish-white nodule that showed no involvement of the adjacent testicular parenchyma or the epididymis.
  • On microscopical examination, there was a well-differentiated adenocarcinoma separated by fibrovascular stroma, entirely confined to the testicular hilum.
  • This primary carcinoma of the rete testis presented as a haematocele.
  • [MeSH-major] Adenocarcinoma / pathology. Hematocele / pathology. Rete Testis / pathology. Testicular Neoplasms / pathology

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  • (PMID = 18043825.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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2. Mermershtain W, Vardi N, Gusakova I, Klein J: Serous papillary adenocarcinoma of the rete testis: unusual ultrasonography and pathological findings. J Cancer Res Ther; 2007 Jan-Mar;3(1):37-9
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  • [Title] Serous papillary adenocarcinoma of the rete testis: unusual ultrasonography and pathological findings.
  • We report a case of serous papillary adenocarcinoma of the rete testis in a 22-year-old man.
  • Adenocarcinoma of the rete testis is highly resistant to radiotherapy and any known chemotherapeutic regimen.
  • [MeSH-major] Cystadenocarcinoma, Serous / pathology. Cystadenocarcinoma, Serous / ultrasonography. Rete Testis. Testicular Neoplasms / pathology. Testicular Neoplasms / ultrasonography

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  • (PMID = 17998718.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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3. Nakagawa T, Hiraoka N, Ihara F, Komiyama M, Kanai Y, Matsuno Y: Primary adenocarcinoma of the rete testis with preceding diagnosis of pulmonary metastases. Int J Urol; 2006 Dec;13(12):1532-5
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  • [Title] Primary adenocarcinoma of the rete testis with preceding diagnosis of pulmonary metastases.
  • We report a case of primary adenocarcinoma of the rete testis in a 55-year-old man with pulmonary metastases that were detected 11 months prior to the diagnosis of the primary lesion.
  • Primary adenocarcinoma of the rete testis is an extremely rare malignant tumor with a poor outcome.
  • The diagnosis is often delayed because of non-specific clinical presentation and symptoms.
  • We cannot forget that rete testis is a possible primary site for a primary, unknown metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Lung Neoplasms / secondary. Rete Testis / pathology. Testicular Neoplasms / pathology

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  • (PMID = 17118031.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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4. Koseoglu RD, Parlaktas BS, Filiz NO, Erdemir F, Uluocak N, Tulunay O: Adenocarcinoma originating from a mature teratoma of the testis. Kaohsiung J Med Sci; 2007 May;23(5):265-8
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  • [Title] Adenocarcinoma originating from a mature teratoma of the testis.
  • Malignant transformation in testicular teratomas has been reported very rarely in the literature.
  • Although testicular teratomas in childhood are regarded as benign neoplasms, these tumors, if left untreated until advanced ages, may present the risk of malignant transformation.
  • We report a case of differentiated adenocarcinoma originating from colonic glands in primary testicular teratoma.
  • [MeSH-major] Adenocarcinoma / pathology. Teratoma / pathology. Testicular Neoplasms / pathology

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  • (PMID = 17525010.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
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5. Baydar DE, Kosemehmetoglu K, Akdogan B, Ozen H: Prostatic adenosquamous carcinoma metastasizing to testis. ScientificWorldJournal; 2006;6:2491-4
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  • [Title] Prostatic adenosquamous carcinoma metastasizing to testis.
  • Most arise after hormonal or radiotherapy of conventional prostatic adenocarcinoma.
  • Here, we present a unique case of "de novo prostatic adenosquamous carcinoma with focal sarcomatoid areas" that showed testicular metastasis, detected after scrotal orchiectomy.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Carcinoma, Adenosquamous / pathology. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / pathology. Testicular Neoplasms / secondary
  • [MeSH-minor] Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Metastasis. Prostate / pathology. Prostate-Specific Antigen / biosynthesis. Testis / pathology. Treatment Outcome

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  • (PMID = 17619723.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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6. Sato S, Noguchi Y, Ohara N, Uenaka A, Shimono M, Nakagawa K, Koizumi F, Ishida T, Yoshino T, Shiratori Y, Nakayama E: Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. Cancer Immun; 2007;7:5
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  • [Title] Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors.
  • XAGE-1 is a cancer/testis (CT) antigen and has been shown to be immunogenic in lung cancer patients.
  • The B cell epitope recognized by the USO9-13 mAb was in the C-terminal region of the XAGE-1b protein and is also recognized by sera from patients with lung adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / immunology. Adenocarcinoma / metabolism. Amino Acid Sequence. Animals. Antibodies, Monoclonal / biosynthesis. B-Lymphocytes / immunology. Cell Nucleus / metabolism. Cells, Cultured. Female. Humans. Lung Neoplasms / immunology. Lung Neoplasms / metabolism. Male. Mice. Mice, Inbred BALB C. Molecular Sequence Data. Protein Isoforms / metabolism. Spermatocytes / metabolism. Spermatogonia / metabolism. Testis / immunology

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  • (PMID = 17335148.001).
  • [ISSN] 1424-9634
  • [Journal-full-title] Cancer immunity
  • [ISO-abbreviation] Cancer Immun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Protein Isoforms; 0 / XAGE1A protein, human
  • [Other-IDs] NLM/ PMC2935747
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7. Bauduceau O, Vedrine L, Chargari C, Ceccaldi B, Le Moulec S, Houlgatte A: [Testicular metastasis of prostatic adenocarcinoma: a case report]. Prog Urol; 2007 Apr;17(2):251-2
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  • [Title] [Testicular metastasis of prostatic adenocarcinoma: a case report].
  • Metastasis of prostate adenocarcinoma to testis is an extremely rare occurrence.
  • Orchiectomy is necessary to confirm histopathological diagnosis.
  • Metastatic carcinoma of the prostate to the testis is a commonly accepted as a sign of disseminated disease.
  • We report a case of a 62-year-old patient who presented a prostatic carcinoma with a testicular metastasis.
  • [MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Testicular Neoplasms / secondary

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  • (PMID = 17489329.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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8. Rubegni P, Poggiali S, De Santi M, Marsili S, Bilenchi R, Miracco C, Fimiani M: Cutaneous metastases from adenocarcinoma of the rete testis. J Cutan Pathol; 2006 Feb;33(2):181-4
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  • [Title] Cutaneous metastases from adenocarcinoma of the rete testis.
  • Adenocarcinoma of the rete testis (ACRT) is extremely rare and has only been the subject of sporadic case reports, in most of which the neoplasm manifested as a scrotal mass with diffuse enlargement of the testis.
  • The diagnosis was based on clinical and histopathological findings and supported by the results of immunohistochemical and ultrastructural studies.
  • We discuss the differential diagnosis to this rare entity, which include metastatic adenocarcinoma, serous tumor of the testis, and mesothelioma of the tunica vaginalis.
  • [MeSH-major] Adenocarcinoma / secondary. Rete Testis / pathology. Skin Neoplasms / secondary. Testicular Neoplasms / pathology

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  • (PMID = 16420316.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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9. Sogni F, Monga G, Terrone C, Gontero P: Primary adenocarcinoma of the rete testis: diagnostic problems and therapeutic dilemmas. Scand J Urol Nephrol; 2008;42(1):83-5
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  • [Title] Primary adenocarcinoma of the rete testis: diagnostic problems and therapeutic dilemmas.
  • We describe a rare case of a malignant tumour of the rete testis which was diagnosed incidentally during scrotal surgery for an apparently benign left hydrocele.
  • Adenocarcinoma of the rete testis is a malignancy with a poor prognosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Testicular Neoplasms / diagnosis. Testicular Neoplasms / surgery
  • [MeSH-minor] Aged. Humans. Incidental Findings. Male. Testicular Hydrocele / surgery

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  • (PMID = 17853037.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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10. Hagiuda J, Matsumoto M, Hanawa Y, Ishikawa H, Marumo K: [Adenocarcinoma of the rete testis. A case report]. Nihon Hinyokika Gakkai Zasshi; 2010 Nov;101(7):749-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenocarcinoma of the rete testis. A case report].
  • Adenocarcinoma of the rete testis is a rare malignant tumor with a poor prognosis.
  • About 60 cases of this adenocarcinoma have been reported in the literature.
  • The diagnosis is often difficult and made incidentally.
  • Herein, we report a case of adenocarcinoma of the rete testis and review the literature.
  • Magnetic resonance imaging (MRI) showed a left hydrocele with central necrosis of the testis.
  • Positron emission tomography (PET) was performed in another hospital, and the patient was referred for a left testicular tumor, multiple lung metastases, and para-aorta lymph node metastasis.
  • Pathological examination revealed a hard whitish mass around the testis involving the epididymis and tunica vaginalis and spreading under the subcutaneous tissue.
  • Histological examination revealed adenocarcinoma in the hilum of the testis, which extended to the subcutaneous tissue but not to the surface of the scrotum.
  • The tunica albuginea was intact, and no invasion of carcinoma in the testis was seen.
  • After the histological diagnosis of adenocarcinoma of the rete testis was confirmed, computed tomography (CT) was performed and showed multiple pulmonary nodules and para-aortica lymph node swelling of 3 cm diameter.
  • Because the patient did not wish to receive chemotherapy or other aggressive treatment, he has been followed-up with palliative care since his diagnosis.
  • Although local recurrence has occurred 4 months later, he is still alive for 8 months since his diagnosis.
  • [MeSH-major] Adenocarcinoma / therapy. Testicular Neoplasms / therapy
  • [MeSH-minor] Aged, 80 and over. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Orchiectomy. Palliative Care. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 21174741.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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11. Maruschke M, Schmidt W, Casper J, Hakenberg OW: Ovarian type surface epithelial carcinoma of the testis with delayed metastatic spread. Urol Int; 2008;81(1):119-21
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  • [Title] Ovarian type surface epithelial carcinoma of the testis with delayed metastatic spread.
  • Ovarian type surface epithelial carcinomas of the testis and paratestis are rare.
  • A 67-year-old patient with a mucinous ovarian type surface carcinoma of the testis is presented.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Testicular Neoplasms / diagnosis. Testicular Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / ultrasonography. Aged. Carcinoembryonic Antigen / metabolism. Female. Humans. Immunohistochemistry / methods. Lymphatic Metastasis. Male. Testis / pathology. Ultrasonography / methods

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18645284.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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12. Gillen S, Feith M, Gertler R, Langer R, Massmann J, Sarbia M, Friess H: Testicular metastasis from adenocarcinoma of the esophagus. Ann Thorac Surg; 2009 Mar;87(3):957-9
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  • [Title] Testicular metastasis from adenocarcinoma of the esophagus.
  • We report the case of a 61-year-old patient, operated on for adenocarcinoma of the esophagus in 2002, who presented in 2007 with a hydrocele and palpable mass of the right testis.
  • Histopathology revealed a testicular and epididymidal metastasis from the esophageal adenocarcinoma.
  • Only a few testicular metastases have been reported from gastrointestinal cancers.
  • No case of testicular metastasis from esophageal cancer, including Barrett's carcinoma has been reported.
  • In most cases, the testicular tumor was accompanied by a hydrocele.
  • Therefore, cancerous and metastatic lesions should be considered in the management of hydrocele and testicular masses.
  • [MeSH-major] Adenocarcinoma / secondary. Esophageal Neoplasms / pathology. Testicular Neoplasms / secondary

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  • (PMID = 19231438.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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13. Joos ZP, Pritchett TR, Porter CR, Isacson C, Picozzi V, Corman JM: Adenocarcinoma of the testicular adnexa presenting with metastatic disease. Can J Urol; 2006 Feb;13(1):2990-2
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  • [Title] Adenocarcinoma of the testicular adnexa presenting with metastatic disease.
  • Primary epididymal adenocarcinoma is a rare malignancy with fewer than 30 documented cases.
  • Histology confirmed the presence of primary paratesticular adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Retroperitoneal Neoplasms / secondary. Testicular Neoplasms / pathology

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  • (PMID = 16515756.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 11
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14. Haupt B, Ro JY, Ayala AG, Zhai J: Metastatic prostatic carcinoma to testis: histological features mimicking lymphoma. Int J Clin Exp Pathol; 2009;2(1):104-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic prostatic carcinoma to testis: histological features mimicking lymphoma.
  • We report a case of prostatic carcinoma with testicular metastasis, which mimicked malignant lymphoma of the testis.
  • The patient was a 71 year-old man with a history of prostate adenocarcinoma of Gleason score 9 (4+5) diagnosed in 2001 for which he received hormonal therapy.
  • However, immunohistochemical stains were positive for prostate-specific antigen and prostate acid phosphatase and negative for leukocyte common antigen, which confirmed the diagnosis of metastatic prostate adenocarcinoma.

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  • (PMID = 18830384.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; lymphoma / metastasis / prostate cancer / testis
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15. Chitale DA, Jungbluth AA, Marshall DS, Leitao MM, Hedvat CV, Kolb D, Spagnoli GC, Iversen K, Soslow RA: Expression of cancer-testis antigens in endometrial carcinomas using a tissue microarray. Mod Pathol; 2005 Jan;18(1):119-26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of cancer-testis antigens in endometrial carcinomas using a tissue microarray.
  • Cancer-testis (CT) antigens are expressed in a variety of malignant tumors, but in normal adult tissue, they are only expressed in testicular germ cells.
  • Formalin-fixed paraffin-embedded tissues of 130 endometrial carcinomas of the following types and grades were analyzed using a tissue microarray: 85 endometrioid carcinomas (FIGO grade 1, 39; grade 2, 11; and grade 3, 35), 18 papillary serous carcinomas, 12 clear cell carcinomas, 13 malignant mixed mullerian tumors, one mucinous adenocarcinoma, and one undifferentiated carcinoma.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / immunology. Adenocarcinoma, Clear Cell / pathology. Carcinoma, Papillary / immunology. Carcinoma, Papillary / pathology. Cystadenocarcinoma, Serous / immunology. Cystadenocarcinoma, Serous / pathology. Female. Humans. Immunohistochemistry. Male. Membrane Proteins / biosynthesis. Mixed Tumor, Mullerian / immunology. Mixed Tumor, Mullerian / pathology. Neoplasm Proteins / biosynthesis. Testis / immunology. Tumor Suppressor Protein p53 / biosynthesis. WT1 Proteins / biosynthesis

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  • (PMID = 15272278.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CT7 antigen, human; 0 / CTAG1B protein, human; 0 / MAGEA3 protein, human; 0 / MAGEA4 protein, human; 0 / MAGEC1 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Protein p53; 0 / WT1 Proteins
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16. Chen YT, Hsu M, Lee P, Shin SJ, Mhawech-Fauceglia P, Odunsi K, Altorki NK, Song CJ, Jin BQ, Simpson AJ, Old LJ: Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer. Int J Cancer; 2009 Jun 15;124(12):2893-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer.
  • CT45 is a cancer/testis gene that we previously identified by massively parallel signature sequencing.
  • Encoded by a multigene family on chromosome X, CT45 showed restricted mRNA expression to normal testis and various cancers.
  • In adult normal tissue, CT45 expression was restricted to testicular germ cells, detected as a nuclear protein mainly at the stage of primary spermatocytes.
  • In tumors, CT45 protein expression correlated with the mRNA levels detected by quantitative RT-PCR, and most lung cancer and ovarian cancers with CT45 mRNA at levels >1% of testicular expression were CT45 protein-positive.
  • In lung cancer, CT45 expression was least frequent in adenocarcinoma, more frequent in squamous cell carcinoma and neuroendocrine tumors.
  • [MeSH-major] Antigens, Neoplasm / genetics. Antigens, Neoplasm / metabolism. Breast Neoplasms / metabolism. Lung Neoplasms / metabolism. Ovarian Neoplasms / metabolism. RNA, Messenger / metabolism. Testicular Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Animals. Antibodies, Monoclonal / immunology. Antibodies, Monoclonal / metabolism. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / secondary. Female. Humans. Male. Mice. Mice, Inbred BALB C. Prognosis. Recombinant Proteins / genetics. Recombinant Proteins / immunology. Recombinant Proteins / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tissue Array Analysis

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  • [Copyright] Copyright 2008 UICC.
  • (PMID = 19296537.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CT45A1 protein, human; 0 / RNA, Messenger; 0 / Recombinant Proteins
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17. Menon S, Gujral S, Bakshi G, Tongaonkar HB: Bilateral testicular metastasis from prostatic adenocarcinoma mimicking an intertubular pattern of seminoma and expressing Rhamm. J Cancer Res Ther; 2010 Jan-Mar;6(1):97-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral testicular metastasis from prostatic adenocarcinoma mimicking an intertubular pattern of seminoma and expressing Rhamm.
  • Adenocarcinoma of prostate metastasizing to testis is a rare occurrence and is incidentally detected in orchiectomy specimens.
  • The pattern of metastasis may mimic a primary neoplasm of testis like a seminoma or lymphoma and pose a diagnostic difficulty for the pathologist.
  • A rare case of bilateral testicular metastasis of prostatic adenocarcinoma is presented wherein the metastatic cells expressed CD168, a receptor for hyaluronan mediated motility (Rhamm), implicated in the development of androgen independence in prostate cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Antigens, CD44 / biosynthesis. Extracellular Matrix Proteins / biosynthesis. Prostatic Neoplasms / pathology. Seminoma / pathology. Testicular Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Agents, Hormonal / therapeutic use. Bone Neoplasms / secondary. Combined Modality Therapy. Diagnosis, Differential. Humans. Leuprolide / therapeutic use. Male. Middle Aged. Orchiectomy. Ultrasound, High-Intensity Focused, Transrectal

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  • (PMID = 20479558.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Antineoplastic Agents, Hormonal; 0 / Extracellular Matrix Proteins; 0 / hyaluronan-mediated motility receptor; EFY6W0M8TG / Leuprolide
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18. Rozniecki JJ, Sahagian GG, Kempuraj D, Tao K, Jocobson S, Zhang B, Theoharides TC: Brain metastases of mouse mammary adenocarcinoma is increased by acute stress. Brain Res; 2010 Dec 17;1366:204-10
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  • [Title] Brain metastases of mouse mammary adenocarcinoma is increased by acute stress.
  • Brain metastases from mammary adenocarcinoma constitute the chief cause of morbidity and mortality.
  • Here we show that acute restraint stress (30 min) induces statistically significant increase in brain metastases of systemically administered luciferase-tagged 4T1-BR-3P mouse mammary adenocarcinoma cells as evidenced by the total brain-associated photons from 5.6 × 10(7) photons in unstressed controls to 1.7 × 10(8) photons in C57BL/6 (p = 0.0018) and from 7.6 × 10(7) to 2.1 × 10(7) photons in BALB/c (p = 0.004) mice.
  • [MeSH-major] Adenocarcinoma / pathology. Brain Neoplasms / pathology. Brain Neoplasms / secondary. Breast Neoplasms / pathology. Restraint, Physical / adverse effects
  • [MeSH-minor] Animals. Blood-Testis Barrier / physiopathology. Brain. Cell Line, Tumor. Corticotropin-Releasing Hormone / metabolism. Diagnostic Imaging / methods. Disease Models, Animal. Female. Mammary Neoplasms, Experimental / pathology. Mice. Mice, Inbred C57BL. Photons

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20887716.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 9015-71-8 / Corticotropin-Releasing Hormone
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19. Gure AO, Chua R, Williamson B, Gonen M, Ferrera CA, Gnjatic S, Ritter G, Simpson AJ, Chen YT, Old LJ, Altorki NK: Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer. Clin Cancer Res; 2005 Nov 15;11(22):8055-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer.
  • PURPOSE: Cancer-testis genes mapping to the X chromosome have common expression patterns and show similar responses to modulators of epigenetic mechanisms.
  • We asked whether cancer-testis gene expression occurred coordinately, and whether it correlated with variables of disease and clinical outcome of non-small cell lung cancer (NSCLC).
  • EXPERIMENTAL DESIGN: Tumors from 523 NSCLC patients undergoing surgery were evaluated for the expression of nine cancer-testis genes (NY-ESO-1, LAGE-1, MAGE-A1, MAGE-A3, MAGE-A4, MAGE-A10, CT7/MAGE-C1, SSX2, and SSX4) by semiquantitative PCR.
  • Clinical data available for 447 patients were used to correlate cancer-testis expression to variables of disease and clinical outcome.
  • RESULTS: At least one cancer-testis gene was expressed by 90% of squamous carcinoma, 62% of bronchioloalveolar cancer, and 67% of adenocarcinoma samples.
  • Statistically significant coexpression was observed for 34 of the 36 possible cancer-testis combinations.
  • Cancer-testis gene expression, either cumulatively or individually, showed significant associations with male sex, smoking history, advanced tumor, nodal and pathologic stages, pleural invasion, and the absence of ground glass opacity.
  • Cox regression analysis revealed the expression of NY-ESO-1 and MAGE-A3 as markers of poor prognosis, independent of confounding variables for adenocarcinoma of the lung.
  • CONCLUSIONS: Cancer-testis genes are coordinately expressed in NSCLC, and their expression is associated with advanced disease and poor outcome.
  • [MeSH-minor] Biomarkers, Tumor / genetics. Chromosomes, Human, X / genetics. Female. Humans. Male. Middle Aged. Prognosis. Reverse Transcriptase Polymerase Chain Reaction. Survival Analysis. Testis / metabolism

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  • (PMID = 16299236.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Membrane Proteins
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20. Domae S, Nakamura Y, Nakamura Y, Uenaka A, Wada H, Nakata M, Oka M, Kishimoto K, Tsukamoto G, Yoshihama Y, Matsuoka J, Gochi A, Kohno S, Saika T, Sasaki A, Nakayama E, Ono T: Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity. Int J Cancer; 2009 May 15;124(10):2347-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity.
  • Cancer/testis (CT) antigens are expressed in normal germ line tissues and various cancers.
  • A testicular cDNA library was immunoscreened with serum obtained from a gastric adenocarcinoma patient whose primary cancer had regressed once and most liver metastases had disappeared transiently.
  • They included 4 genes with testis-specific expression profiles in the Unigene database, including coiled-coil domain containing 62 (CCDC62).
  • RT-PCR analysis showed that the expression of 2 splice variants of CCDC62 was restricted to the testis in normal adult tissues.
  • [MeSH-major] Adenocarcinoma / immunology. Antigens, Neoplasm / immunology. Stomach Neoplasms / immunology. Testis / immunology. Transcription Factors / immunology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 19165854.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CCDC62 protein, human; 0 / DNA Primers; 0 / DNA, Complementary; 0 / RNA, Messenger; 0 / Recombinant Proteins; 0 / Transcription Factors
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21. Ulbright TM, Young RH: Metastatic carcinoma to the testis: a clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features. Am J Surg Pathol; 2008 Nov;32(11):1683-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic carcinoma to the testis: a clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features.
  • Metastatic carcinomas to the testis may simulate primary testicular neoplasms, even in patients with known extratesticular primaries, but information on this topic is limited.
  • We conclude that, if autopsy cases and incidental tumors in therapeutic orchiectomy specimens are excluded, metastatic carcinomas to the testis are usually solitary, unilateral tumors that may simulate primary neoplasms, including rete adenocarcinoma and Sertoli cell tumor.
  • Despite the rarity of documented cases in the literature, the bladder and renal pelvis should not be overlooked as possible sources for testicular metastasis.
  • The pathologist must have a high index of suspicion for the possibility of a metastatic carcinoma to the testis for any testicular tumor where the routine light microscopic or immunohistochemical findings are unusual for a primary neoplasm.
  • [MeSH-major] Carcinoma / secondary. Testicular Neoplasms / secondary

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  • (PMID = 18769334.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Shigematsu Y, Hanagiri T, Shiota H, Kuroda K, Baba T, Mizukami M, So T, Ichiki Y, Yasuda M, So T, Takenoyama M, Yasumoto K: Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer. Lung Cancer; 2010 Apr;68(1):105-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer.
  • Cancer/testis antigens (CT antigens) are thought to be suitable targets for antigen-specific immunotherapy, because of the cancer-specific expression except for the testis among various normal tissues and no-expression of HLA class I in the testis.
  • Both of MAGE-A3 and MAGE-A4 were expressed more frequently in squamous cell carcinoma than in adenocarcinoma (p<0.01).
  • KK-LC-1 was expressed in 32.1% of patients with adenocarcinoma and in 36.5% of patients with squamous cell carcinoma.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Carcinoma, Non-Small-Cell Lung / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Sex Factors. Survival Analysis. Testis / metabolism

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19545928.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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23. Okada T, Akada M, Fujita T, Iwata T, Goto Y, Kido K, Okada T, Matsuzaki Y, Kobayashi K, Matsuno S, Sunamura M, Kawakami Y: A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers. Clin Cancer Res; 2006 Jan 1;12(1):191-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers.
  • PURPOSE: To isolate cancer testis antigens that are expressed in pancreatic cancers and may be useful in clinical applications.
  • EXPERIMENTAL DESIGN: To efficiently isolate cancer testis antigens, a testis cDNA library was immunoscreened (SEREX) with serum from a patient with pancreatic ductal adenocarcinoma.
  • RESULTS: Of the three clones isolated through screening of a total of 2 x 10(6) cDNA library clones, one clone (KU-CT-1) was found to be expressed in various cancers but only in testis among normal tissues, indicating that it was a novel cancer testis antigen.
  • CONCLUSIONS: KU-CT-1 is a new cancer testis antigen that is expressed in pancreatic, lung, and endometrial cancers and may be useful for diagnosis and immunotherapy for patients with various cancers.
  • [MeSH-minor] Amino Acid Sequence. Base Sequence. Blotting, Northern. Cell Line, Tumor. Endometrial Neoplasms / genetics. Female. Humans. Lung Neoplasms / genetics. Male. Molecular Sequence Data. Pancreatic Neoplasms / genetics. Reverse Transcriptase Polymerase Chain Reaction. Testis / physiology

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  • (PMID = 16397042.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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24. Kuo CY, Wen MC, Wang J, Jan YJ: Signet-ring stromal tumor of the testis: a case report and literature review. Hum Pathol; 2009 Apr;40(4):584-7
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  • [Title] Signet-ring stromal tumor of the testis: a case report and literature review.
  • Primary signet-ring stromal tumor of the testis is extremely rare.
  • Herein, we present a case of testicular signet-ring stromal tumor with positive immunostain for CD99, which has not been reported previously.
  • The most important differential diagnosis of signet-ring stromal tumor is metastatic signet-ring cell carcinoma because of its different management and prognosis.
  • Fortunately, signet-ring stromal tumors have a well-defined growth pattern, bland histological features, no mucin production, and immunoreaction to vimentin rather than cytokeratin, all of which help pathologists to rule out metastatic adenocarcinoma.
  • [MeSH-major] Sex Cord-Gonadal Stromal Tumors / pathology. Testicular Neoplasms / pathology

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  • (PMID = 18835626.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules
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25. Baek KH, Lee HJ, Kim MS, Kim YS, Seong M, Lee EJ, Lee MY: Molecular cloning of rHAUSP encoding a deubiquitinating enzyme in rat testis. Oncol Rep; 2006 Jan;15(1):173-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular cloning of rHAUSP encoding a deubiquitinating enzyme in rat testis.
  • In this study, we have identified a rat orthologue of HAUSP, rHAUSP, from the rat testis by RT-PCR using primers used for cloning mHAUSP. rHAUSP cDNA encodes 3,312 bp and 1,103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains characteristic of the ubiquitin-specific processing proteases. pI value of rHAUSP is 5.31.
  • The over-expression of rHAUSP induced cell death of cervical adenocarcinoma cells.
  • [MeSH-major] Apoptosis. Endopeptidases / genetics. Testis / enzymology


26. Tomaszewski JJ, Smaldone MC, Benoit RM: Inguinal canal recurrence of colorectal adenocarcinoma following cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. Can J Urol; 2008 Dec;15(6):4428-30
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  • [Title] Inguinal canal recurrence of colorectal adenocarcinoma following cytoreductive surgery and intraperitoneal hyperthermic chemotherapy.
  • We present the case of a 35-year-old male with locally recurrent colorectal adenocarcinoma in the inguinal canal and testis following intraperitoneal debulking and IPHC.
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Adenocarcinoma / therapy. Colorectal Neoplasms / therapy. Hyperthermia, Induced. Inguinal Canal / radionuclide imaging. Neoplasms, Second Primary / radionuclide imaging. Testicular Neoplasms / radionuclide imaging

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  • (PMID = 19046498.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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27. Sheridan T, Herawi M, Epstein JI, Illei PB: The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate. Am J Surg Pathol; 2007 Sep;31(9):1351-5
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  • [Title] The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate.
  • BACKGROUND: Adenocarcinoma of the prostate can present as metastatic carcinoma with no known primary.
  • The tissue microarray contains 78 cases of metastatic prostatic adenocarcinoma, 20 cases of primary prostatic adenocarcinoma, and 20 cases of benign prostate tissue from the peripheral zone as well as samples of benign brain, pancreas, kidney, thyroid, testis, skeletal muscle, and fibroconnective tissue.
  • A small subset of metastatic prostatic adenocarcinoma shows significant differences in staining intensity and extent for PSA and P501S and, therefore, combined use of these markers may result in increased sensitivity for detecting prostatic origin.
  • [MeSH-major] Adenocarcinoma / diagnosis. Membrane Proteins / analysis. Neoplasms, Unknown Primary / diagnosis. Prostate-Specific Antigen / analysis. Prostatic Neoplasms / diagnosis

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  • (PMID = 17721190.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA58236
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / prostein; EC 3.4.21.77 / Prostate-Specific Antigen
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28. Grah J, Samija M, Juretić A, Sarcević B, Sobat H: Immunohystochemical expression of cancer/testis antigens (MAGE-A3/4, NY-ESO-1) in non-small cell lung cancer: the relationship with clinical-pathological features. Coll Antropol; 2008 Sep;32(3):731-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohystochemical expression of cancer/testis antigens (MAGE-A3/4, NY-ESO-1) in non-small cell lung cancer: the relationship with clinical-pathological features.
  • The aim of this study was to explore the expression of cancer/testis tumor associated antigens (C/T TAAs) MAGE-A 3/4 and NY-ESO-1 in lung squamous cell carcinoma and adenocarcinoma, and to evaluate their association with the standard clinical-pathological features of surgically treated lung cancer patients.
  • A statistically higher MAGE-A3/4 expression was observed in planocellular bronchial carcinoma (p < 0.001), while no difference was found in the expression of NY-ESO-1 in adenocarcinoma and planocellular carcinoma (p = 0.144).
  • A significant association was found between the MAGE-A3/4 expression and presence of tumor necrosis in squamous cell cancer specimens (p = 0.001), but not in adenocarcinoma (p = 0.033).
  • A statistically significant association was noted between the NY-ESO-1 expression and positive hilar and mediastinal lymph nodes in adenocarcinoma (p = 0.025) whereas it was not the case in squamous cell carcinoma.
  • Non-small cell lung cancer frequently expresses cancer/testis tumor associated antigens.
  • [MeSH-major] Adenocarcinoma / pathology. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / pathology. Lung Neoplasms / parasitology. Membrane Proteins / analysis. Neoplasm Proteins / analysis

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  • (PMID = 18982744.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CTAG1B protein, human; 0 / MAGEA3 protein, human; 0 / MAGEA4 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins
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29. Amin MB: Selected other problematic testicular and paratesticular lesions: rete testis neoplasms and pseudotumors, mesothelial lesions and secondary tumors. Mod Pathol; 2005 Feb;18 Suppl 2:S131-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selected other problematic testicular and paratesticular lesions: rete testis neoplasms and pseudotumors, mesothelial lesions and secondary tumors.
  • The proximity and, in some instances, communication between several structures in the testis and paratestis (rete testis, epididymis, mesothelium, vestigial epithelium and paratesticular soft tissue) result in a plethora of interesting tumors and tumor-like lesions that together pose a formidable diagnostic challenge both because of their morphologic overlap and rarity.
  • This review provides an overview of the pathology of nonmesenchymal paratesticular neoplasms and pseudotumors with a focus on the approach to tubulopapillary neoplasms for which diagnostic considerations may include carcinoma of the rete testis, malignant mesothelioma, ovarian-type epithelial tumors, epididymal carcinoma and metastatic carcinomas.
  • [MeSH-major] Testicular Neoplasms / pathology. Testis / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenomatoid Tumor / metabolism. Adenomatoid Tumor / pathology. Algorithms. Biomarkers, Tumor / analysis. Cystadenocarcinoma, Papillary / metabolism. Cystadenocarcinoma, Papillary / pathology. Cystadenocarcinoma, Serous / metabolism. Cystadenocarcinoma, Serous / pathology. Diagnosis, Differential. Epithelium / chemistry. Epithelium / pathology. Humans. Hyperplasia. Immunohistochemistry. Male. Mesothelioma / metabolism. Mesothelioma / pathology. Rete Testis / chemistry. Rete Testis / pathology

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  • (PMID = 15502808.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 48
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30. Kim SH, Lee S, Lee CH, Lee MK, Kim YD, Shin DH, Choi KU, Kim JY, Park DY, Sol MY: Expression of cancer-testis antigens MAGE-A3/6 and NY-ESO-1 in non-small-cell lung carcinomas and their relationship with immune cell infiltration. Lung; 2009 Nov-Dec;187(6):401-11
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of cancer-testis antigens MAGE-A3/6 and NY-ESO-1 in non-small-cell lung carcinomas and their relationship with immune cell infiltration.
  • Cancer-testis antigens (CTAs) are expressed only in many cancers and limited immunoprivileged sites such as the testis and placenta.
  • Immunohistochemical staining to CTAs such as MAGE-A3/6 and NY-ESO-1 was performed using paraffin blocks from 132 cases of NSCLCs, including 75 cases of squamous cell carcinoma (SqCC) and 57 cases of adenocarcinoma (AdC), and the results were evaluated to correlate with tumor-infiltrating DCs and CTLs and clinicopathologic features.
  • [MeSH-minor] Adenocarcinoma / immunology. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adult. Carcinoma, Squamous Cell / immunology. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Female. Humans. Korea. Male. Middle Aged. Neoplasm Staging. Prognosis. T-Lymphocytes, Cytotoxic / immunology

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  • (PMID = 19795170.001).
  • [ISSN] 1432-1750
  • [Journal-full-title] Lung
  • [ISO-abbreviation] Lung
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CTAG1B protein, human; 0 / MAGEA3 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins
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31. Wang CT, Zhang P, Wang YS, Ruan XZ, Li ZY, Peng F, Yang HS, Wei YQ: RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells. Cell Mol Biol Lett; 2009;14(3):363-76

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells.
  • Biot2 is a novel murine testis-specific gene that was first identified using the SEREX technique, and named by our laboratory.
  • The results revealed that the Biot2 transcript was detected only and strongly in the testis tissues and abundantly in five types of murine cancer cell line.
  • Treating B16 murine melanoma, LL/2 murine Lewis lung carcinoma and CT26 murine colorectal adenocarcinoma with special shRNA targeting Biot2 can significantly reduce the proliferation rate of these three tumor cell lines in vitro, as measured by the MTT, colony-forming and BrdU incorporation assays.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Neoplasms, Experimental / therapy. RNA Interference. Testis / metabolism

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  • (PMID = 19277478.001).
  • [ISSN] 1689-1392
  • [Journal-full-title] Cellular & molecular biology letters
  • [ISO-abbreviation] Cell. Mol. Biol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / 1700008F21Rik protein, mouse; 0 / Antigens, Neoplasm
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32. Nakamura Y, Tanaka F, Nagahara H, Ieta K, Haraguchi N, Mimori K, Sasaki A, Inoue H, Yanaga K, Mori M: Opa interacting protein 5 (OIP5) is a novel cancer-testis specific gene in gastric cancer. Ann Surg Oncol; 2007 Feb;14(2):885-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Opa interacting protein 5 (OIP5) is a novel cancer-testis specific gene in gastric cancer.
  • We also compared the expression status of OIP5 with that of the other known cancer-testis specific genes.
  • A human total RNA master panel demonstrated that OIP5, but not Exo1 or CDC6, showed high specificity in testis.
  • Thus OIP5 may be considered a cancer-testis specific gene.
  • CONCLUSIONS: Using a combination of LMD and microarray, we identified OIP5 as a cancer-testis specific gene.
  • [MeSH-major] Adenocarcinoma / genetics. Antigens, Neoplasm / genetics. Exoribonucleases / genetics. Stomach Neoplasms / genetics
  • [MeSH-minor] Aged. Aged, 80 and over. Carrier Proteins / genetics. Gene Expression Profiling. Humans. Male. Microdissection. Middle Aged. Oligonucleotide Array Sequence Analysis. Testis / immunology

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  • (PMID = 17151793.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carrier Proteins; EC 3.1.- / Exoribonucleases
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33. Yoshida N, Abe H, Ohkuri T, Wakita D, Sato M, Noguchi D, Miyamoto M, Morikawa T, Kondo S, Ikeda H, Nishimura T: Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance. Int J Oncol; 2006 May;28(5):1089-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance.
  • Cancer-testis (CT) antigens were identified as a group of highly attractive targets for cancer immunotherapy because of their expression in a variety of malignant tumors but solely in the testis among the normal adult tissues.
  • Both CT antigens were more frequently expressed in squamous cell carcinoma (SCC) than in adenocarcinoma.

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  • (PMID = 16596224.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CTAG1B protein, human; 0 / Cancer Vaccines; 0 / DNA Primers; 0 / MAGEA4 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins
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34. Ishikawa N, Takano A, Yasui W, Inai K, Nishimura H, Ito H, Miyagi Y, Nakayama H, Fujita M, Hosokawa M, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y: Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas. Cancer Res; 2007 Dec 15;67(24):11601-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas.
  • Gene expression profile analyses of non-small cell lung carcinomas (NSCLC) and esophageal squamous cell carcinomas (ESCC) revealed that lymphocyte antigen 6 complex locus K (LY6K) was specifically expressed in testis and transactivated in a majority of NSCLCs and ESCCs.
  • A combined ELISA for both LY6K and CEA classified 64.7% of lung adenocarcinoma patients as positive, and the use of both LY6K and CYFRA 21-1 increased sensitivity in the detection of lung squamous cell carcinomas and ESCCs up to 70.4% and 52.5%, respectively, whereas the false positive rate was 6.8% to 9.5%.
  • Our data imply that a cancer-testis antigen, LY6K, should be useful as a new type of tumor biomarker and probably as a target for the development of new molecular therapies for cancer treatment.


35. Kikuchi E, Yamazaki K, Nakayama E, Sato S, Uenaka A, Yamada N, Oizumi S, Dosaka-Akita H, Nishimura M: Prolonged survival of patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens. Cancer Immun; 2008;8:13
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  • [Title] Prolonged survival of patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens.
  • XAGE-1b is a cancer/testis antigen that has been shown to be expressed at a significant frequency and to be immunogenic in non-small cell lung cancer (NSCLC).
  • XAGE-1b expression was observed in 27 (32.5%) adenocarcinoma specimens.
  • [MeSH-major] Adenocarcinoma / immunology. Antigens, Neoplasm / metabolism. Carcinoma, Non-Small-Cell Lung / immunology. Histocompatibility Antigens Class I / immunology. Lung Neoplasms / immunology

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  • [Cites] Nat Rev Cancer. 2005 Aug;5(8):615-25 [16034368.001]
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  • (PMID = 18752338.001).
  • [ISSN] 1424-9634
  • [Journal-full-title] Cancer immunity
  • [ISO-abbreviation] Cancer Immun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Histocompatibility Antigens Class I; 0 / XAGE1A protein, human
  • [Other-IDs] NLM/ PMC2935781
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36. Yang KC, Chao Y, Luo JC, Kuo JY, Lee RC, Li AF, Li CP: The unusual presentation of gastric adenocarcinoma as a testicular mass: a favorable response to docetaxel and Cisplatin plus oral tegafur/uracil and leucovorin. J Chin Med Assoc; 2010 Feb;73(2):88-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The unusual presentation of gastric adenocarcinoma as a testicular mass: a favorable response to docetaxel and Cisplatin plus oral tegafur/uracil and leucovorin.
  • Testicular metastasis is rare.
  • We present here a 23-year-old gastric cancer patient who first presented with right-side testis swelling and pain.
  • Diagnosis of metastatic adenocarcinoma was made after right-side orchiectomy.
  • Gastric adenocarcinoma with ascites and peritoneal seeding was found after esophagogastroscopy and abdominal computed tomography.
  • Metastatic tumors, especially gastric adenocarcinoma, should be considered in the differential diagnosis of patients presenting with testicular mass and they may respond well to chemotherapy.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Stomach Neoplasms / drug therapy. Testicular Neoplasms / secondary

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  • [Copyright] Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20171588.001).
  • [ISSN] 1728-7731
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Taxoids; 1548R74NSZ / Tegafur; 15H5577CQD / docetaxel; 56HH86ZVCT / Uracil; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin
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37. Huffman DM, Johnson MS, Watts A, Elgavish A, Eltoum IA, Nagy TR: Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake. Cancer Res; 2007 Jan 1;67(1):417-24
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  • [Title] Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake.
  • In the first experiment, transgenic mice that spontaneously develop prostate cancer [transgenic adenocarcinoma of mouse prostate (TRAMP)] were housed at 27 degrees C or 22 degrees C and pair fed the same diet for 21 weeks (95% of ad libitum intake at 27 degrees C).
  • Furthermore, PF27 mice had greater levels of serum leptin (P < 0.001), lower levels of adiponectin (P < 0.05), and a greater frequency of prostatic adenocarcinoma (P < 0.05).
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / prevention & control. Caloric Restriction. Prostatic Neoplasms / metabolism. Prostatic Neoplasms / prevention & control
  • [MeSH-minor] Adiponectin / blood. Animals. Body Composition. Disease Progression. Eating. Energy Metabolism. Leptin / blood. Male. Mice. Mice, Inbred C57BL. Mice, Transgenic. Organ Size. Testis / anatomy & histology. Testosterone / blood

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  • (PMID = 17185379.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 101058; United States / NCI NIH HHS / CA / CA 47888; United States / NIDDK NIH HHS / DK / P30 DK 56336
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Leptin; 3XMK78S47O / Testosterone
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38. Morales A, Vilchis F, Chávez B, Chan C, Robles-Díaz G, Díaz-Sánchez V: Expression and localization of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) in human pancreas and pancreatic adenocarcinoma. J Steroid Biochem Mol Biol; 2007 Oct;107(1-2):37-41
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  • [Title] Expression and localization of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) in human pancreas and pancreatic adenocarcinoma.
  • EG-VEGF (the gene product of PROK-1) appears to be expressed exclusively in steroid-producing organs such as the ovary, testis, adrenals and placenta.
  • Since the human pancreatic cells retain steroidogenic activity, in the present study we ascertained whether this angiogenic factor is expressed in normal pancreas and pancreatic adenocarcinoma.
  • The relative amount of EG-VEGF mRNA in pancreas was more abundant in female adenocarcinoma (0.89) followed by male adenocarcinoma (0.71), than normal female (0.64) and normal male (0.38).
  • [MeSH-major] Adenocarcinoma / metabolism. Gastrointestinal Hormones / metabolism. Pancreas / metabolism. Pancreatic Neoplasms / metabolism. RNA, Messenger / metabolism. Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / metabolism

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  • (PMID = 17683928.001).
  • [ISSN] 0960-0760
  • [Journal-full-title] The Journal of steroid biochemistry and molecular biology
  • [ISO-abbreviation] J. Steroid Biochem. Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gastrointestinal Hormones; 0 / PROK1 protein, human; 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
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39. Yin M, Dhir R, Parwani AV: Diagnostic utility of p501s (prostein) in comparison to prostate specific antigen (PSA) for the detection of metastatic prostatic adenocarcinoma. Diagn Pathol; 2007;2:41
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  • [Title] Diagnostic utility of p501s (prostein) in comparison to prostate specific antigen (PSA) for the detection of metastatic prostatic adenocarcinoma.
  • BACKGROUND: Immunohistochemical detection of prostate specific antigen (PSA) is widely used to identify metastatic prostatic adenocarcinoma.
  • The purpose of this study was to evaluate the expression of P501s in metastatic prostatic adenocarcinoma and compare its expression with PSA.
  • The TMA is constructed with normal donor prostates (NDP), prostatic adenocarcinoma (PRCA), non-neoplastic prostatic tissues adjacent to malignant glands (NAT), benign prostatic hyperplasia (BPH), high-grade prostatic neoplasia (PIN), metastatic adenocarcinoma to lymph nodes (MLN), metastatic adenocarcinoma to other sites (MC), and samples of benign testis, colon, adrenal and kidney.
  • No staining was observed in controls including testis, colon, adrenal and kidney.

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  • (PMID = 17963516.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2174437
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40. Fukuyama T, Hanagiri T, Takenoyama M, Ichiki Y, Mizukami M, So T, Sugaya M, So T, Sugio K, Yasumoto K: Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma. Cancer Res; 2006 May 1;66(9):4922-8
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  • [Title] Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma.
  • We established a lung adenocarcinoma cell line, designated as F1121L, and induced tumor-specific CTL clone H1 from regional lymph node lymphocytes of patient F1121.
  • A reverse transcription-PCR analysis revealed that the mRNA of this gene was only expressed in the testis among normal tissues.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / immunology. Antigens, Neoplasm / genetics. Lung Neoplasms / genetics. Lung Neoplasms / immunology. T-Lymphocytes, Cytotoxic / immunology


41. Ruiz JM, Sanchis CM, López PC, Navarro HP, Moreno MJ, Sánchez AS, Tobarra MA, Rodríguez JA: Metastasis to the tunica vaginalis testis from a primary mucinous tumor of the cecum. Arch Esp Urol; 2010 Apr;63(3):235-8
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis to the tunica vaginalis testis from a primary mucinous tumor of the cecum.
  • OBJECTIVES: We review the literature about secondary testicular tumors.
  • METHODS: We present the case of a patient with a metastatic mucus-secreting testicular tumor who presented in the emergency room with symptoms of acute scrotum 10 months after surgery for a mixed tumor of the cecum.
  • Our patient died 21 months after the initial diagnosis CONCLUSIONS: Testicular metastases and mucus-secreting intestinal tumor metastases are rare.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Cecal Neoplasms / pathology. Testicular Neoplasms / secondary

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  • (PMID = 20436228.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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42. Hommell J, Ragage F, Pinatel B, Ruffion A, Decaussin-Petrucci M: [Isolated testicular mass revealing a metastasis of prostate adenocarcinoma]. Ann Pathol; 2009 Dec;29(6):488-90
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Isolated testicular mass revealing a metastasis of prostate adenocarcinoma].
  • A testicular mass on a patient over 50 years should be considered as a metastasis, a lymphoma or a spermatocytic seminoma.
  • Testicular metastases are rare, representing about 1 % of all testicular tumors.
  • Metastases revealed by a testicular mass are very rare.
  • We report the original case of an 80-year-old patient with a left testicular mass indicating a metastasis of a prostate carcinoma diagnosed six years earlier.
  • [MeSH-major] Adenocarcinoma / pathology. Prostatic Neoplasms / pathology. Testicular Neoplasms / secondary. Testis / pathology

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  • (PMID = 20005437.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Androgens; EC 3.4.21.77 / Prostate-Specific Antigen
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43. Ghochikyan A, Mkrtichyan M, Loukinov D, Mamikonyan G, Pack SD, Movsesyan N, Ichim TE, Cribbs DH, Lobanenkov VV, Agadjanyan MG: Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites. J Immunol; 2007 Jan 1;178(1):566-73
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  • [Title] Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites.
  • These cytolytic responses were observed across a wide range of different mouse cancers including mammary adenocarcinoma, glioma, leukemia, and mastocytoma.

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  • (PMID = 17182597.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AI044809-06; United States / NIAID NIH HHS / AI / R01 AI044809; United States / NIAID NIH HHS / AI / R01 AI044809-06; United States / NIA NIH HHS / AG / AG020241-06; United States / NIAID NIH HHS / AI / R01 AI-44809; United States / NINDS NIH HHS / NS / R01 NS050895; United States / NINDS NIH HHS / NS / NS050895-04; United States / NIA NIH HHS / AG / R01 AG020241; United States / NIA NIH HHS / AG / R01 AG-20241; United States / NIA NIH HHS / AG / R01 AG020241-06; United States / NINDS NIH HHS / NS / R01 NS-050895; United States / NINDS NIH HHS / NS / R01 NS050895-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Antigens, CD4; 0 / Antigens, Neoplasm; 0 / Cancer Vaccines; 0 / Ctcfl protein, mouse; 0 / DNA-Binding Proteins; 0 / Histocompatibility Antigens Class I; 0 / Interleukin-18; 0 / Vaccines, DNA; 187348-17-0 / Interleukin-12
  • [Other-IDs] NLM/ NIHMS47187; NLM/ PMC2377412
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44. Kurian RR, Prema NS, Belthazar A: Paratesticular papillary serous cystadenocarcinoma--a case report. Indian J Pathol Microbiol; 2006 Jan;49(1):36-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • They are thought to arise from Mullerian metaplasia of the peritoneal lining of the tunica vaginalis, appendix testis or mullerian remnants between the testis and spermatic cord.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Cystadenocarcinoma, Serous / pathology. Testicular Neoplasms / pathology. Testis / pathology

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  • (PMID = 16625973.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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45. Lin CY, Jwo SC, Lin CC: Primary testicular actinomycosis mimicking metastatic tumor. Int J Urol; 2005 May;12(5):519-21
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  • [Title] Primary testicular actinomycosis mimicking metastatic tumor.
  • We report a rare case of right primary testicular actinomycosis presenting as multiple testicular lesions mimicking a metastatic tumor in a 71-year-old patient with gastric adenocarcinoma.
  • Preoperative diagnosis is difficult.
  • The enlarged and inflamed testis was removed by orchiectomy and testicular actinomycosis was diagnosed after pathological examination.
  • We illustrate this case, though it is rare, to alert pathologists and clinicians to the possible occurrence of primary testicular actinomycosis mimicking metastatic lesions in a cancer patient.
  • We also reviewed the published literature and found that the treatment of choice for testicular actinomycosis was orchiectomy.
  • [MeSH-major] Actinomycosis / diagnosis. Orchitis / diagnosis
  • [MeSH-minor] Actinomyces / isolation & purification. Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Aged. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Neoplasm Metastasis / diagnosis. Orchiectomy. Stomach Neoplasms / complications. Stomach Neoplasms / diagnosis. Testis / microbiology. Testis / pathology. Testis / ultrasonography

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  • (PMID = 15948759.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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46. Hoffmann MJ, Müller M, Engers R, Schulz WA: Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies. Biochem Pharmacol; 2006 Nov 30;72(11):1577-88

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aberrant hypomethylation in many cancers reactivates retrotransposons and selected single-copy genes such as cancer-testis antigens.
  • Genes reactivated in this manner have recently been postulated to include CTCFL/BORIS, a presumptive testis-specific chromatin regulator, and OCT4/POU5F1, a transcriptional activator in pluripotent cells.
  • We found both genes expressed at high levels in testis and at much lower levels in normal prostate tissue.
  • Thus, CTCFL and OCT4 resemble cancer-testis antigens in being selectively hypomethylated and expressed in male germ cells but differ in lacking significant reexpression and hypomethylation in prostate carcinomas.
  • [MeSH-major] Adenocarcinoma / genetics. DNA-Binding Proteins / genetics. Epigenesis, Genetic. Gene Expression Regulation, Neoplastic. Octamer Transcription Factor-3 / genetics. Testis. Urogenital Neoplasms / genetics. Zinc Fingers / genetics

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  • (PMID = 16854382.001).
  • [ISSN] 0006-2952
  • [Journal-full-title] Biochemical pharmacology
  • [ISO-abbreviation] Biochem. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTCFL protein, human; 0 / DNA-Binding Proteins; 0 / Octamer Transcription Factor-3; 0 / RNA, Messenger
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47. Deb P, Chander Y, Rai RS: Testicular metastasis from carcinoma of prostate: report of two cases. Prostate Cancer Prostatic Dis; 2007;10(2):202-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular metastasis from carcinoma of prostate: report of two cases.
  • Despite the high incidence of prostatic adenocarcinoma and its ability for wide dissemination, metastatic involvement of testis is rather uncommon.
  • We report two cases (aged 76 and 55 years, respectively), where unilateral testicular metastasis was incidentally discovered after bilateral orchiectomy following detection of adenocarcinoma prostate in six-quadrant trucut specimen.
  • Both patients had obstructive voiding symptoms, hard nodular prostate on direct rectal examination and raised serum prostate-specific antigen levels, without associated systemic or testicular symptoms.
  • These cases highlight the need for proper evaluation of testes and para-testicular structures, for accurate staging of these tumors and to exclude any possible metastasis.
  • [MeSH-major] Adenocarcinoma / pathology. Prostatic Neoplasms / pathology. Testicular Neoplasms / secondary

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  • (PMID = 17224911.001).
  • [ISSN] 1365-7852
  • [Journal-full-title] Prostate cancer and prostatic diseases
  • [ISO-abbreviation] Prostate Cancer Prostatic Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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48. Tagami K, Tanda S, Tokumura H, Yamaguchi M: [A case of triple malignant tumors consisting of esophagus, stomach and malignant lymphoma with a histopathological feature of collision between gastric cancer and malignant lymphoma--a case report]. Gan To Kagaku Ryoho; 2010 Dec;37(13):2891-5
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  • A 73-year-old man complained of gross hematuria and swelling of the right testis.
  • He was diagnosed with malignant diffuse large B cell lymphoma by immunostaining from the extirpated right testis.
  • During this chemotherapy, he felt epigastralgia; esophagus cancer (squamous cell carcinoma) and stomach cancer (highly-differentiated adenocarcinoma) were found by upper endoscopy.
  • Pathological examination revealed that the adenocarcinoma had partly collided with the malignant lymphoma.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Esophageal Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology

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  • (PMID = 21160264.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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49. Pointis G, Fiorini C, Defamie N, Segretain D: Gap junctional communication in the male reproductive system. Biochim Biophys Acta; 2005 Dec 20;1719(1-2):102-16

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Male fertility is a highly controlled process that allows proliferation, meiosis and differentiation of male germ cells in the testis, final maturation in the epididymis and also requires functional male accessory glands: seminal vesicles, prostate and corpus cavernosum.
  • The present review is focused on the identification of Cxs, their distribution in the testis and in different structures of the male genital tract (epididymis, seminal vesicle, prostate, corpus cavernosum), their crucial role in the control of spermatogenesis and their implication in the function of the male accessory glands, including functional smooth muscle tone.
  • Their potential dysfunctions in some testis (spermatogenic arrest, seminoma) and prostate (benign hyperplasia, adenocarcinoma) diseases and in the physiopathology of the human erectile function are also discussed.
  • [MeSH-major] Cell Communication. Connexins / physiology. Gap Junctions / physiology. Spermatogenesis. Testis / metabolism

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  • (PMID = 16259941.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Connexins
  • [Number-of-references] 156
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50. Zhang JM, Hashimoto M, Kawai K, Murakumo Y, Sato T, Ichihara M, Nakamura S, Takahashi M: CD109 expression in squamous cell carcinoma of the uterine cervix. Pathol Int; 2005 Apr;55(4):165-9
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  • The authors have recently reported that high expression of the CD109 gene was detected in approximately half of the examined lung and esophageal squamous cell carcinomas as well as in the testis, and that CD109 has the characteristics of a cancer-testis antigen.
  • In the present study CD109 expression in cervical squamous cell carcinoma was compared with that in endometrial adenocarcinoma by reverse transcription polymerase chain reaction (RT-PCR).
  • In contrast, when expression of RET finger protein (RFP) and bromodomain testis-specific (BRDT) genes, which are also known to be highly expressed in the testis, was examined, no significant difference in their expression levels was observed between squamous cell carcinomas and adenocarcinomas.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Cell Line, Tumor. DNA-Binding Proteins / genetics. Endometrial Neoplasms / genetics. Endometrial Neoplasms / pathology. Female. GPI-Linked Proteins. Gene Expression Regulation, Neoplastic. HeLa Cells. Humans. Neoplasm Proteins. Nuclear Proteins / genetics. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction


56. Rahardjo HE, Umbas R, Sutisna H: Testicular metastases from prostate carcinoma. Asian J Surg; 2010 Jul;33(3):154-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular metastases from prostate carcinoma.
  • Metastasis of prostate carcinoma to the testis is seldom reported.
  • Clinical manifestations of secondary testicular tumours from the prostate are most often unsuspected clinically and are instead detected incidentally during orchidectomy.
  • Less frequently, a palpable mass is detected, which may be confused with a primary testicular neoplasm.
  • We report a case of a 66-year-old patient with adenocarcinoma of the prostate, and a left testicular tumour that was diagnosed as metastases from prostate carcinoma after radical orchidectomy.

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  • [Copyright] Copyright © 2010 Asian Surgical Association. Published by Elsevier B.V. All rights reserved.
  • (PMID = 21163414.001).
  • [ISSN] 0219-3108
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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57. Conde E, Suarez-Gauthier A, García-García E, Lopez-Rios F, Lopez-Encuentra A, García-Lujan R, Morente M, Sanchez-Verde L, Sanchez-Cespedes M: Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. Hum Pathol; 2007 Sep;38(9):1351-60
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  • Our analysis in normal tissues revealed strong LKB1 immunostaining in most epithelia, in the seminiferous tubules of the testis, in myocytes from skeletal muscle, and in glia cells.
  • Regarding phospho-ACC (p-ACC), strong immunostaining was observed in myocytes from the skeletal muscle and heart, and in Leydig cells of the testis.
  • Finally, high p-ACC was an independent marker for prediction of better survival in lung adenocarcinoma patients.
  • In conclusion, our observations provide complete information about the pattern and levels of LKB1 and p-ACC immunostaining in normal tissues and in lung tumors, and highlight the special relevance of abnormalities of the LKB1 pathway in lung adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Phosphorylation. Predictive Value of Tests. Prognosis. Tissue Distribution

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  • (PMID = 17521700.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 6.4.1.2 / Acetyl-CoA Carboxylase
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58. Kohno H, Suzuki R, Sugie S, Tsuda H, Tanaka T: Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats. Clin Cancer Res; 2005 Jul 1;11(13):4962-7
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  • RESULTS: Dietary feeding with 500 ppm silymarin significantly inhibited the incidence of prostatic adenocarcinoma when compared with the DMAB-alone group (17.6% versus 50.0%, P < 0.05).
  • Also, dietary administration of silymarin increased apoptotic index in prostatic adenocarcinoma by measuring immunohistochemically positive nuclei for ssDNA.
  • [MeSH-major] Adenocarcinoma / prevention & control. Antioxidants / administration & dosage. Dietary Supplements. Prostatic Neoplasms / prevention & control. Silymarin / administration & dosage
  • [MeSH-minor] Aminobiphenyl Compounds. Animals. Body Weight / drug effects. Cyclin D1 / analysis. Immunohistochemistry. Liver / drug effects. Liver / pathology. Male. Organ Size / drug effects. Proliferating Cell Nuclear Antigen / analysis. Prostate / drug effects. Prostate / pathology. Rats. Rats, Inbred F344. Testis / drug effects. Testis / pathology. Treatment Outcome

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  • (PMID = 16000596.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminobiphenyl Compounds; 0 / Antioxidants; 0 / Proliferating Cell Nuclear Antigen; 0 / Silymarin; 13394-86-0 / 2',3-dimethyl-4-aminobiphenyl; 136601-57-5 / Cyclin D1
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59. Gurel B, Ali TZ, Montgomery EA, Begum S, Hicks J, Goggins M, Eberhart CG, Clark DP, Bieberich CJ, Epstein JI, De Marzo AM: NKX3.1 as a marker of prostatic origin in metastatic tumors. Am J Surg Pathol; 2010 Aug;34(8):1097-105
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A recent study showed that NKX3.1 staining with a novel antibody was highly sensitive and specific for high-grade prostatic adenocarcinoma when compared with high-grade urothelial carcinoma.
  • The purpose of this study was to determine the performance of NKX3.1 as a marker of metastatic adenocarcinoma of prostatic origin.
  • Immunohistochemical staining against NKX3.1, PSA, and PSAP was carried out on a tissue microarray (TMA) (0.6-mm tissue cores) of hormone naïve metastatic prostate adenocarcinoma specimens from lymph nodes, bone, and soft tissue.
  • To determine the specificity of NKX3.1 for prostatic adenocarcinoma, we used TMAs that contained cancers from various sites including the urinary bladder, breast, colon, salivary gland, stomach, pancreas, thyroid, and central nervous system, and standard paraffin sections of cancers from other sites including the adrenal cortex, kidney, liver, lung, and testis.
  • NKX3.1 seems to be a highly sensitive and specific tissue marker of metastatic prostatic adenocarcinoma.

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  • (PMID = 20588175.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA058236-16; United States / NCI NIH HHS / CA / P50 CA058236; United States / NCI NIH HHS / CA / P30 CA006973; United States / NCI NIH HHS / CA / P50 CA058236-16; United States / NCI NIH HHS / CA / P50 CA058236-07; United States / NCI NIH HHS / CA / P50 CA58236
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Homeodomain Proteins; 0 / NKX3-1 protein, human; 0 / Transcription Factors; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen
  • [Other-IDs] NLM/ NIHMS272269; NLM/ PMC3072223
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60. Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, Karnezis AN, Swigart LB, Nasi S, Evan GI: Modelling Myc inhibition as a cancer therapy. Nature; 2008 Oct 2;455(7213):679-83
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  • We have modelled genetically both the therapeutic impact and the side effects of systemic Myc inhibition in a preclinical mouse model of Ras-induced lung adenocarcinoma by reversible, systemic expression of a dominant-interfering Myc mutant.


61. Krassas GE, Pontikides N: Gonadal effect of radiation from 131I in male patients with thyroid carcinoma. Arch Androl; 2005 May-Jun;51(3):171-5
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  • For patients treated with a single ablation dose, testicular function recovers within months and the risk of infertility is diminished.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Fertility / radiation effects. Iodine Radioisotopes / adverse effects. Testis / radiation effects. Thyroid Neoplasms / radiotherapy

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  • (PMID = 16025855.001).
  • [ISSN] 0148-5016
  • [Journal-full-title] Archives of andrology
  • [ISO-abbreviation] Arch. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
  • [Number-of-references] 13
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62. Schmitz-Winnenthal FH, Galindo-Escobedo LV, Rimoldi D, Geng W, Romero P, Koch M, Weitz J, Krempien R, Niethammer AG, Beckhove P, Buchler MW, Z'graggen K: Potential target antigens for immunotherapy in human pancreatic cancer. Cancer Lett; 2007 Jul 18;252(2):290-8
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  • Cancer Testis antigens (CT) are antigens shared by a variety of malignant tumors, but not by normal tissues with the exception of germ cells in testis.
  • METHODS: Pancreatic adenocarcinoma tumor samples (n=130) were obtained intraoperatively, control tissues (n=23) were collected from cadaveric donor and from patients with chronic pancreatitis.
  • [MeSH-major] Adenocarcinoma / therapy. Antigens, Neoplasm / immunology. Immunotherapy. Pancreatic Neoplasms / therapy

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  • (PMID = 17320278.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA Primers; M801H13NRU / Azacitidine
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63. Nakagawa K, Noguchi Y, Uenaka A, Sato S, Okumura H, Tanaka M, Shimono M, Ali Eldib AM, Ono T, Ohara N, Yoshino T, Yamashita K, Tsunoda T, Aoe M, Shimizu N, Nakayama E: XAGE-1 expression in non-small cell lung cancer and antibody response in patients. Clin Cancer Res; 2005 Aug 1;11(15):5496-503
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  • PURPOSE: XAGE-1 was originally identified by the search for PAGE/GAGE-related genes using expressed sequence tag database and was shown to exhibit characteristics of cancer/testis-like antigens.
  • We recently identified XAGE-1b as a dominant antigen recognized by sera from lung adenocarcinoma patients.
  • XAGE-1b mRNA expression was observed in 14 of 31 (45%) adenocarcinoma and 1 of 18 (6%) lung cancer with other histologic types.
  • Seropositivity was observed in 5 of 56 patients with adenocarcinoma, whereas none of 18 patients with other histologic types produced XAGE-1b antibody.
  • CONCLUSION: XAGE-1b is highly and strongly expressed in lung adenocarcinoma and immunogenic in patients, suggesting that XAGE-1b is a promising antigen for immunotherapy against lung adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Antibodies, Monoclonal / chemistry. Blotting, Western. DNA Primers / chemistry. DNA, Complementary / metabolism. Databases as Topic. Enzyme-Linked Immunosorbent Assay. Expressed Sequence Tags. Genetic Vectors. Humans. Immunohistochemistry. Immunotherapy / methods. Plasmids / metabolism. Protein Structure, Tertiary. RNA, Messenger / metabolism. Recombinant Proteins / chemistry. Recombinant Proteins / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Treatment Outcome

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  • [CommentIn] Clin Cancer Res. 2005 Aug 1;11(15):5331-2 [16061843.001]
  • (PMID = 16061866.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / DNA Primers; 0 / DNA, Complementary; 0 / RNA, Messenger; 0 / Recombinant Proteins; 0 / XAGE1A protein, human
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64. Venkitaraman R, George M, Weerasooriya S, Selva-Nayagam S: Late solitary testicular metastasis from rectal cancer. J Cancer Res Ther; 2010 Jan-Mar;6(1):89-91
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  • [Title] Late solitary testicular metastasis from rectal cancer.
  • Isolated testicular metastasis from rectal cancer is rare.
  • He developed a painless testicular nodule while on follow-up, five years after the diagnosis of primary rectal cancer.
  • Histopathology and immunohistochemistry of orchidectomy specimen were compatible with a metastatic adenocarcinoma of rectal origin.
  • Treatment of late isolated relapse in the testis needs to be ascertained.
  • [MeSH-major] Adenocarcinoma / secondary. Rectal Neoplasms / pathology. Testicular Neoplasms / secondary

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  • (PMID = 20479555.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] U3P01618RT / Fluorouracil
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65. Kassis ES, Zhao M, Hong JA, Chen GA, Nguyen DM, Schrump DS: Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells. J Thorac Cardiovasc Surg; 2006 Feb;131(2):298-306
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

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  • METHODS: CALU-6 and A549 lung cancer, SKGT5 and BIC esophageal adenocarcinoma, and H2373 and H2052 malignant pleural mesothelioma (MPM) cells, as well as normal human bronchial epithelial (NHBE) cells, were transfected with phosphorothioate-modified antisense oligos targeting DNMT1, DNMT3b, or both, or mismatch oligos.
  • The antiproliferative effects of the antisense oligos were not attributable to induction of RASSF1A, p16, or p21 tumor suppressor genes, and did not coincide with demethylation of genes encoding cancer-testis antigens.
  • [MeSH-major] Adenocarcinoma / physiopathology. Apoptosis / physiology. DNA (Cytosine-5-)-Methyltransferase / physiology. Esophageal Neoplasms / physiopathology. Lung Neoplasms / physiopathology. Mesothelioma / physiopathology. Pleural Neoplasms / physiopathology


66. Matsuzaki M, Nakano M, Komatsu H, Ohashi K: [Aortic replacement during post chemotherapy retroperitoneal residual tumor resection for nonseminomatous germ cell tumor: a case report]. Hinyokika Kiyo; 2005 Dec;51(12):831-4
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  • His left testis was hard and swollen.
  • Under the diagnosis of testicular tumor and retroperitoneal lymph node metastasis, left radical orchiectomy was performed and the histopathological examination showed mature teratoma.
  • Histopathological diagnosis was cystopapillary adenocarcinoma and mature teratoma.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Aorta, Abdominal / surgery. Lymph Node Excision. Lymph Nodes / pathology. Neoplasms, Multiple Primary. Teratoma / surgery. Testicular Neoplasms / surgery

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  • (PMID = 16440734.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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67. Gallego R, Pintos E, García-Caballero T, Raghay K, Boulanger L, Beiras A, Gaudreau P, Morel G: Cellular distribution of growth hormone-releasing hormone receptor in human reproductive system and breast and prostate cancers. Histol Histopathol; 2005 07;20(3):697-706
Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .

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  • [MeSH-major] Breast Neoplasms / metabolism. Ovary / metabolism. Prostatic Neoplasms / metabolism. Receptors, Neuropeptide / metabolism. Receptors, Pituitary Hormone-Regulating Hormone / metabolism. Testis / metabolism
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Female. Humans. Immunohistochemistry. In Situ Hybridization. Male. Mammary Glands, Human / metabolism. Placenta / metabolism. Pregnancy. RNA, Messenger / genetics. RNA, Messenger / metabolism. Uterus / metabolism

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  • (PMID = 15944917.001).
  • [ISSN] 0213-3911
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptors, Neuropeptide; 0 / Receptors, Pituitary Hormone-Regulating Hormone; 0 / somatotropin releasing hormone receptor
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68. Camparo P, Durand X, Avances C, Culine S, Segui B, Rigaud J, Membres du GELU-Groupe d'Etude des Lésions Urologiques, Membres du CCAFU: [Histological features and principles of treating testicle tumors in the elderly subject]. Prog Urol; 2009 Nov;19 Suppl 3:S142-6
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  • After the 6th decade, primitive lymphomas are the most frequent tumors of the testis (>30%).
  • The one of metastasis depends on primitive tumor (prostatic or pulmonary adenocarcinoma or melanoma mainly).
  • This particular histological profile must be in mind when considering the appropriate therapeutic approach of testis tumors in elderly.
  • [MeSH-major] Testicular Neoplasms / pathology

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  • [Copyright] (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20123499.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Investigator] Choudat L; Priollet BC; Comperat E; Sibony M; Vassiliu V; Verkarre V; Allory Y; Ferlicot S; Molinié V; Denoux Y; Sautet A; Lesourd A; Trillet M; Petit T; Aillet G; Vieillefond A; Boccon-Gibod L
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69. Antic T, Staerkel G: Mediastinal epithelioid hemangioendothelioma metastatic to lymph nodes and pleural fluid: report of a case. Diagn Cytopathol; 2010 Feb;38(2):113-6
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  • Involvement of numerous sites of the body, including visceral organs, soft tissue, testis, skeleton, brain, meninges, and skin have been described.
  • The patient had a complex history of papillary renal cell carcinoma, papillary thyroid carcinoma, and Waldenstrom's hyperglobulinemia making the diagnosis of metastatic epithelioid hemangioendothelioma difficult.
  • [MeSH-minor] Adenocarcinoma, Papillary / complications. Aged. Biopsy, Fine-Needle. Carcinoma, Renal Cell / complications. Female. Humans. Immunohistochemistry. Kidney Neoplasms / complications. Leukemia, Lymphocytic, Chronic, B-Cell / complications. Stomach Neoplasms / complications. Thyroid Neoplasms / complications. Thyroiditis / complications. Waldenstrom Macroglobulinemia / complications

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  • (PMID = 19688765.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Janssen S, Bernhards J, Anastasiadis AG, Bruns F: Solitary testicular metastasis from prostate cancer: a rare case of isolated recurrence after radical prostatectomy. Anticancer Res; 2010 May;30(5):1747-9
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  • [Title] Solitary testicular metastasis from prostate cancer: a rare case of isolated recurrence after radical prostatectomy.
  • An isolated testicular metastasis of PC is rare.
  • Unfortunately, the PSA level rose again, accompanied by a swelling of the left testis approximately one month after radiotherapy.
  • A unilateral orchiectomy was then performed, presenting a testicular metastasis of the PC.
  • In particular, rare metastatic sites such as the testis or the epididymis should be taken into account before treatment of biochemical recurrence is initiated.
  • [MeSH-major] Prostatectomy / methods. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / pathology. Testicular Neoplasms / diagnosis. Testicular Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / therapy. Aged. Epididymis / pathology. Humans. Immunohistochemistry / methods. Male. Neoplasm Metastasis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / therapy. Orchiectomy / methods. Prostate-Specific Antigen / blood. Recurrence


76. Bennett VS, Bailey DM: Cholangiocarcinoma presenting as a solitary epididymal metastasis: a case report and review of the literature. Diagn Pathol; 2007;2:33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Computed tomography of the abdomen demonstrated an obstructive stricture of the extra-hepatic bile ducts, in keeping with a cholangiocarcinoma, through which a metal stent was endoscopically inserted for symptomatic relief.Subsequent right radical orchidectomy yielded a diffusely infiltrative adenocarcinoma obliterating the epididymis, extending into the rete testis, vas deferens and spermatic cord and showing widespread vascular and perineural invasion.
  • Residual epididymal, rete, and testicular tubules showed no in situ neoplasia.
  • CONCLUSION: Only two cases of bile duct carcinoma metastasising to the male genital tract have previously been reported in the literature, the testis being the main site of metastasis in both cases.

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  • (PMID = 17760973.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2000863
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77. Manikandan R, Nathaniel C, Reeve N, Brough RJ: Bilateral testicular metastases from prostatic carcinoma. Int J Urol; 2006 Apr;13(4):476-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral testicular metastases from prostatic carcinoma.
  • Testicular metastasis from carcinoma of the prostate is rare.
  • We report a case of carcinoma of the prostate with bilateral testicular metastases 7 years after the initial diagnosis.
  • Although testicular metastasis is uncommon, it should be considered when a patient presents with a lump in the testis, particularly in a patient known to have another primary malignancy.
  • [MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Testicular Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Orchiectomy. Prostate-Specific Antigen / blood

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  • (PMID = 16734881.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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78. Erkekoğlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F: Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells. Free Radic Biol Med; 2010 Aug 15;49(4):559-66
Hazardous Substances Data Bank. SELENIUM METHIONINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It plays a critical role in testis and reproduction and regulates DNA damage within the prostate.
  • The objective of this study was to investigate the cytotoxicity and genotoxicity potentials of di(2-ethylhexyl)phthalate (DEHP), the most widely used phthalate and its primary toxic metabolite mono(2-ethylhexyl)phthalate (MEHP), and their effects on the antioxidant balance in the LNCaP human prostate adenocarcinoma cell line.

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  • Hazardous Substances Data Bank. BIS(2-ETHYLHEXYL) PHTHALATE .
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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20466057.001).
  • [ISSN] 1873-4596
  • [Journal-full-title] Free radical biology & medicine
  • [ISO-abbreviation] Free Radic. Biol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 4376-20-9 / mono-(2-ethylhexyl)phthalate; 964MRK2PEL / Selenomethionine; C42K0PH13C / Diethylhexyl Phthalate; HIW548RQ3W / Sodium Selenite
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79. Lai Q, Zhang L, Sun Y: [Association of XAGE-1 gene expression with clinical characteristics of lung cancer]. Zhongguo Fei Ai Za Zhi; 2010 Aug;13(8):786-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND AND OBJECTIVE: XAGE-1 is a cancer-testis (CT) antigen which was demonstrated to be expressed at a significant frequency and to be immunogenic in some tumors.
  • CONCLUSION: XAGE-1 gene is highly expressed in lung adenocarcinoma and XAGE-1 may be a promising immunotherapeutic target for lung cancer.

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  • (PMID = 20704819.001).
  • [ISSN] 1999-6187
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / XAGE1A protein, human
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80. Huang P, Duda DG, Jain RK, Fukumura D: Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice. Comp Med; 2008 Jun;58(3):253-63
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  • All tumors in male mice were lung alveolar-bronchiolar (AB) neoplasms, except for 1 testis interstitial cell tumor.
  • One mammary adenocarcinoma (MCaP0008) and 1 lung AB carcinoma (LAP0297) were successfully transplanted subcutaneously and passaged serially in vivo.

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  • [Cites] Genesis. 2000 Oct;28(2):75-81 [11064424.001]
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  • (PMID = 18589867.001).
  • [ISSN] 1532-0820
  • [Journal-full-title] Comparative medicine
  • [ISO-abbreviation] Comp. Med.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA115767-04; United States / NCI NIH HHS / CA / R01 CA085140; United States / NCI NIH HHS / CA / R01-CA115767; United States / NCI NIH HHS / CA / P01 CA080124; United States / NCI NIH HHS / CA / R01-CA85140; United States / NCI NIH HHS / CA / R01 CA115767; United States / NCI NIH HHS / CA / R01 CA096915; United States / NCI NIH HHS / CA / R01 CA085140-08; United States / NCI NIH HHS / CA / P01 CA080124-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS108990; NLM/ PMC2693079
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81. Jung Y, Park J, Bang YJ, Kim TY: Gene silencing of TSPYL5 mediated by aberrant promoter methylation in gastric cancers. Lab Invest; 2008 Feb;88(2):153-60
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  • The gene TSPYL5, encoding testis-specific Y-like protein, was previously identified in microarray screens for genes induced by the inhibition of DNA methylation and histone deacetylation in glioma cell lines.
  • [MeSH-major] Adenocarcinoma / genetics. Nuclear Proteins / genetics. Stomach Neoplasms / genetics

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  • (PMID = 18059362.001).
  • [ISSN] 1530-0307
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / TSPYL5 protein, human
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82. Goetz AK, Rockett JC, Ren H, Thillainadarajah I, Dix DJ: Inhibition of rat and human steroidogenesis by triazole antifungals. Syst Biol Reprod Med; 2009 Dec;55(5-6):214-26
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  • Hormone production was measured in testis organ cultures from untreated adult and neonatal rats, following in vitro exposure to 1, 10, or 100 muM of myclobutanil or triadimefon.
  • Myclobutanil and triadimefon reduced media levels of testosterone by 40-68% in the adult and neonatal testis culture, and altered steroid production in a manner that indicated CYP17-hydroxylase/17,20 lyase (CYP17A1) inhibition at the highest concentration tested.
  • Rat to human comparison was explored using the H295R (human adrenal adenocarcinoma) cell line.
  • However, in vivo exposure of rats to triazoles resulted in increased serum and intra-testicular testosterone levels.

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  • (PMID = 19938956.001).
  • [ISSN] 1939-6376
  • [Journal-full-title] Systems biology in reproductive medicine
  • [ISO-abbreviation] Syst Biol Reprod Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Nitriles; 0 / Steroids; 0 / Triazoles; 0 / systhane; 142KW8TBSR / propiconazole; 3XMK78S47O / Testosterone; 43121-43-3 / triadimefon; EC 1.14.99.9 / CYP17A1 protein, human; EC 1.14.99.9 / Steroid 17-alpha-Hydroxylase
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83. Monappa V, Rao AC, Krishnanand G, Mathew M, Garg S: Adenomatoid tumor of tunica albuginea mimicking seminoma on fine needle aspiration cytology: a case report. Acta Cytol; 2009 May-Jun;53(3):349-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The epididymis is the most common site of involvement; however, it can also arise from the tunica albuginea, spermatic cord, tunica vaginalis and testis.
  • We report the cytologic features of a case of adenomatoid tumor arising from testicular tunica albuginea.
  • Histopathologic examination confirmed the diagnosis as adenomatoid tumor of tunica albuginea.
  • It is thus important to consider this tumor in the differential diagnosis of scrotal swellings.
  • [MeSH-major] Adenomatoid Tumor / pathology. Seminoma / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Adult. Biopsy, Fine-Needle. Cystadenoma, Papillary / diagnosis. Diagnosis, Differential. Epithelium / pathology. Humans. Hyperplasia / diagnosis. Male. Mesothelioma / diagnosis. Orchiectomy

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  • (PMID = 19534283.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Winstanley AM, Landon G, Berney D, Minhas S, Fisher C, Parkinson MC: The immunohistochemical profile of malignant mesotheliomas of the tunica vaginalis: a study of 20 cases. Am J Surg Pathol; 2006 Jan;30(1):1-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant mesotheliomas of the testis arise from the tunica vaginalis, formed from the evagination of the abdominal peritoneum into the scrotum.
  • Testicular series are uncommon, usually derived from previous case studies and literature reviews.
  • Archival testicular malignant mesothelioma specimens from 1959 to 2004 were collected from hospitals throughout the United Kingdom and from the authors' own archives.
  • In all cases, the morphologic light microscopy criteria for a diagnosis of malignant mesothelioma were present.
  • However, two tumors were later excluded from the study because of diffuse strong positive immunostaining with CK20 and BerEp4 and an ultrastructural appearance of adenocarcinoma.
  • Four of the 18 cases were examined by electron microscopy, which revealed long thin microvilli supporting a diagnosis of malignant mesothelioma.
  • This study has shown that the immunocytochemical profile of testicular malignant mesotheliomas is similar to those arising in the pleura, with diffuse positivity for calretinin, EMA, thrombomodulin, and CK7, and negative for CK20 and CEA.
  • However, histopathologists should be aware of the variability in CK5-6 staining in testicular specimens when compared with pleural mesotheliomas.
  • [MeSH-major] Biomarkers, Tumor / analysis. Mesothelioma / metabolism. Mesothelioma / ultrastructure. Testicular Neoplasms / metabolism. Testicular Neoplasms / ultrastructure

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  • (PMID = 16330935.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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85. Tanaka F, Haraguchi N, Isikawa K, Inoue H, Mori M: Potential role of dendritic cell vaccination with MAGE peptides in gastrointestinal carcinomas. Oncol Rep; 2008 Nov;20(5):1111-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, no expression is observed in normal tissues except testis.
  • [MeSH-major] Adenocarcinoma / therapy. Antigens, Neoplasm / immunology. Cancer Vaccines / therapeutic use. Dendritic Cells / transplantation. Gastrointestinal Neoplasms / therapy. Immunotherapy, Active / methods. Neoplasm Proteins / immunology

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  • (PMID = 18949409.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cancer Vaccines; 0 / MAGEA3 protein, human; 0 / Neoplasm Proteins; 0 / Peptides
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86. Huang L, Song M, Yang HS, Zhang YG, Hu HZ: [Cloning, expression, distribution and subcellular localization of AK078438 gene]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2007 Jun;24(3):271-4
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  • RESULTS: The full open reading frame of AK078438 gene with 1065 bp, 355aa were identified. mRNA of the gene distributed in brain, uterus, colon, bone marrow, testis and kidney, but not in stomach, liver, the lung, spleen and heart.
  • Murine colon adenocarcinoma C26, melanoma B16, Lewis lung carcinoma LL/2 and MSC had the gene and mouse myeloma cell line NS-1 and Hepa mouse hepatoma cell line had no the gene.

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  • (PMID = 17557235.001).
  • [ISSN] 1003-9406
  • [Journal-full-title] Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
  • [ISO-abbreviation] Zhonghua Yi Xue Yi Chuan Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Proteins; 0 / RNA, Messenger
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87. Zhou Q, Guo AL, Xu CR, An SJ, Wang Z, Yang SQ, Wu YL: A dendritic cell-based tumour vaccine for lung cancer: full-length XAGE-1b protein-pulsed dendritic cells induce specific cytotoxic T lymphocytes in vitro. Clin Exp Immunol; 2008 Sep;153(3):392-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • XAGE-1b is regarded as one of the most immunogenic antigens and the most promising targets for lung adenocarcinoma immunotherapy.
  • These results can be used to develop simple and effective cancer/testis antigen-based immunotherapies for NSCLC.
  • [MeSH-major] Adenocarcinoma / immunology. Carcinoma, Non-Small-Cell Lung / immunology. Dendritic Cells / immunology. Lung Neoplasms / immunology. T-Lymphocytes, Cytotoxic / immunology

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  • (PMID = 18803763.001).
  • [ISSN] 1365-2249
  • [Journal-full-title] Clinical and experimental immunology
  • [ISO-abbreviation] Clin. Exp. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / RNA, Messenger; 0 / XAGE1A protein, human
  • [Other-IDs] NLM/ PMC2527369
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88. Kumar PV, Shirazi M, Salehi M: A diagnostic pitfall of fine needle aspiration cytology in testicular papillary serous cyst adenoma: a case report. Acta Cytol; 2009 Jul-Aug;53(4):467-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A diagnostic pitfall of fine needle aspiration cytology in testicular papillary serous cyst adenoma: a case report.
  • BACKGROUND: Testicular neoplasmns resembling ovarian serous tumors are rarely reported.
  • CASE: A 35-year-old man presented with an enlarged right testis.
  • Metastatic papillary adenocarcinoma was suspected based on FNAB cytology.
  • CONCLUSION: Papillary serous cystadenoma of the testis is a rare tumor.
  • [MeSH-major] Biopsy, Fine-Needle. Cystadenoma, Papillary / pathology. Cystadenoma, Serous / pathology. Testicular Neoplasms / pathology

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  • (PMID = 19697740.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Li J, Ji C, Zheng H, Fei X, Zheng M, Dai J, Gu S, Xie Y, Mao Y: Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains. Cell Mol Biol Lett; 2005;10(1):185-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RT-PCR revealed that hLrp2bp was mainly expressed in the human testis, small intestine, colon and blood leukocytes, and in human pancreatic adenocarcinoma cells.

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  • (PMID = 15809689.001).
  • [ISSN] 1425-8153
  • [Journal-full-title] Cellular & molecular biology letters
  • [ISO-abbreviation] Cell. Mol. Biol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / LRP2BP protein, human; 0 / Low Density Lipoprotein Receptor-Related Protein-2
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90. Kim J, Reber HA, Hines OJ, Kazanjian KK, Tran A, Ye X, Amersi FF, Martinez SR, Dry SM, Bilchik AJ, Hoon DS: The clinical significance of MAGEA3 expression in pancreatic cancer. Int J Cancer; 2006 May 1;118(9):2269-75
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  • The MAGEA gene family that encodes cancer testis antigens is differentially expressed in many cancers.
  • Though MAGEA3 expression has been detected in gastrointestinal malignancies, its role in pancreatic ductal adenocarcinoma (PDAC) has not been well established.

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  • [Copyright] 2005 Wiley-Liss, Inc.
  • (PMID = 16331618.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MAGEA3 protein, human; 0 / Neoplasm Proteins
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91. Chan PC, Sills RC, Kissling GE, Nyska A, Richter W: Induction of thyroid and liver tumors by chronic exposure to 2-methylimidazole in F344/N rats and B6C3F1 mice. Arch Toxicol; 2008 Jun;82(6):399-412
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  • Significant increases in incidences were also observed in spleen hematopoietic cell proliferation in both sexes and bone marrow hyperplasia, chronic active inflammation of the epididymis, sperm granuloma, and germinal epithelial atrophy of the testis in males.
  • [MeSH-major] Adenocarcinoma / chemically induced. Adenoma / chemically induced. Carcinogens / toxicity. Imidazoles / toxicity. Liver Neoplasms / chemically induced. Thyroid Neoplasms / chemically induced

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  • (PMID = 17924096.001).
  • [ISSN] 0340-5761
  • [Journal-full-title] Archives of toxicology
  • [ISO-abbreviation] Arch. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Imidazoles; 0 / Thyroid Hormones; 693-98-1 / 2-methylimidazole; 9002-71-5 / Thyrotropin; EC 2.4.1.17 / Glucuronosyltransferase
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92. Albino G, Nenna R, Inchingolo CD, Marucco EC: Hydrocele with surprise. Case report and rewiew of literature. Arch Ital Urol Androl; 2010 Dec;82(4):287-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Hydrocele is a fluid collection between tunica vaginalis and testis.
  • Approximately 10% of testicular cancers occurs with a reactive hydrocele.
  • Rhabdomyosarcoma is the most common, followed by mesothelioma, adenocarcinoma and neuroblastoma.

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  • (PMID = 21341584.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
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93. Locke JA, Bruchovsky N: Prostate cancer: finasteride extends PSA doubling time during intermittent hormone therapy. Can J Urol; 2010 Jun;17(3):5162-9
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  • OBJECTIVES: Finasteride has been shown to prolong the time off-treatment in men with prostate cancer during intermittent androgen suppression therapy, but it is not clear whether this results from an increase in prostate-specific antigen (PSA) doubling time or a delay in PSA responsiveness to regained testicular function.
  • In the following study, we distinguish between these two possibilities and consider how the effectiveness of finasteride might be altered if androgens are synthesized within the malignant cell rather than the testis.
  • [MeSH-major] Adenocarcinoma / blood. Adenocarcinoma / drug therapy. Finasteride / therapeutic use. Prostate-Specific Antigen / blood. Prostate-Specific Antigen / drug effects. Prostatic Neoplasms / blood. Prostatic Neoplasms / drug therapy

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  • [CommentIn] Can J Urol. 2010 Jun;17(3):5169 [20566008.001]
  • (PMID = 20566007.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 57GNO57U7G / Finasteride; EC 3.4.21.77 / Prostate-Specific Antigen
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94. Lotem J, Netanely D, Domany E, Sachs L: Human cancers overexpress genes that are specific to a variety of normal human tissues. Proc Natl Acad Sci U S A; 2005 Dec 20;102(51):18556-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Of 91 stable clusters obtained, 24 clusters included genes preferentially expressed either only in hematopoietic tissues or in hematopoietic and one to two other tissues; 28 clusters included genes preferentially expressed in various nonhematopoietic tissues such as neuronal, testis, liver, kidney, muscle, lung, pancreas, and placenta.
  • [MeSH-minor] Adenocarcinoma / genetics. Cell Line. Cell Line, Tumor. Health. Humans. Leukemia / classification. Leukemia / genetics. Multigene Family / genetics

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  • (PMID = 16339305.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1317977
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95. Mannaa F, Ahmed HH, Estefan SF, Sharaf HA, Eskander EF: Saccharomyces cerevisiae intervention for relieving flutamide-induced hepatotoxicity in male rats. Pharmazie; 2005 Sep;60(9):689-95
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  • The aim of this work was to investigate the protective role of baker's yeast Saccharomyces cerevisiae against the hepatotoxic effect of the drug flutamide that is widely used for treatment of metastatic prostate adenocarcinoma.
  • [MeSH-minor] Animals. Cobalt / metabolism. Enzyme-Linked Immunosorbent Assay. Glutathione Peroxidase / metabolism. Liver / pathology. Liver Function Tests. Male. Rats. Rats, Sprague-Dawley. Selenium / metabolism. Superoxide Dismutase / metabolism. Testis / drug effects. Tumor Necrosis Factor-alpha / metabolism. Zinc / metabolism

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  • Hazardous Substances Data Bank. COBALT, ELEMENTAL .
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  • (PMID = 16222870.001).
  • [ISSN] 0031-7144
  • [Journal-full-title] Die Pharmazie
  • [ISO-abbreviation] Pharmazie
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Androgen Antagonists; 0 / Tumor Necrosis Factor-alpha; 3G0H8C9362 / Cobalt; 76W6J0943E / Flutamide; EC 1.11.1.9 / Glutathione Peroxidase; EC 1.15.1.1 / Superoxide Dismutase; H6241UJ22B / Selenium; J41CSQ7QDS / Zinc
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96. Menchini-Fabris F, Giannarini G, Pomara G, De Maria M, Manassero F, Mogorovich A, Selli C: Testicular metastasis as isolated recurrence after radical prostatectomy. A first case. Int J Impot Res; 2007 Jan-Feb;19(1):108-9
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  • [Title] Testicular metastasis as isolated recurrence after radical prostatectomy. A first case.
  • Prostate cancer synchronously or metachronously metastasizing to the testis is a rare finding.
  • We herein report on the first case of a solitary testicular metastasis from an organ-confined prostate cancer, diagnosed 6 months after a radical prostatectomy, without evidence of previous or concomitant biochemical and local recurrence.
  • [MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / surgery. Testicular Neoplasms / secondary

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  • (PMID = 16554855.001).
  • [ISSN] 0955-9930
  • [Journal-full-title] International journal of impotence research
  • [ISO-abbreviation] Int. J. Impot. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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97. Spiess PE, Pisters LL, Liu P, Pettaway CA, Kamat AM, Gomez JA, Tannir NM: Malignant transformation of testicular teratoma: a chemoresistant phenotype. Urol Oncol; 2008 Nov-Dec;26(6):595-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of testicular teratoma: a chemoresistant phenotype.
  • RESULTS: Two patients presented with clinical stage I disease in which malignant transformation occurred within the primary testis tumor (rhabdomyosarcoma in 1 and adenocarcinoma in 1).
  • The MTT histology of these RPLND specimens consisted of adenocarcinoma (N = 3), rhabdomyosarcoma (N = 2), angiosarcoma (N = 1), and astrocytoma (N = 1).
  • [MeSH-major] Teratoma / drug therapy. Testicular Neoplasms / drug therapy

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  • (PMID = 18367105.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS610854; NLM/ PMC4121060
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98. Godoy A, Ulloa V, Rodríguez F, Reinicke K, Yañez AJ, García Mde L, Medina RA, Carrasco M, Barberis S, Castro T, Martínez F, Koch X, Vera JC, Poblete MT, Figueroa CD, Peruzzo B, Pérez F, Nualart F: Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. J Cell Physiol; 2006 Jun;207(3):614-27
The Lens. Cited by Patents in .

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  • GLUT6 was principally detected in testis germinal cells and GLUT9 was localized in kidney, liver, heart, and adrenal.
  • GLUT5 was detected in 27% of breast and colon adenocarcinoma, liver carcinoma, lymphomas, and testis seminoma samples.

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16523487.001).
  • [ISSN] 0021-9541
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucose Transport Proteins, Facilitative
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99. Liang Y: An expression meta-analysis of predicted microRNA targets identifies a diagnostic signature for lung cancer. BMC Med Genomics; 2008;1:61
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  • BACKGROUND: Patients diagnosed with lung adenocarcinoma (AD) and squamous cell carcinoma (SCC), two major histologic subtypes of lung cancer, currently receive similar standard treatments, but resistance to adjuvant chemotherapy is prevalent.
  • RESULTS: Computationally predicted target genes of three microRNAs, miR-34b/34c/449, that were detected in human lung, testis, and fallopian tubes but not in other normal tissues, were filtered by representation of GO terms and their ability to classify lung cancer subtypes, followed by a meta-analysis of microarray data to classify AD and SCC.

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  • (PMID = 19087325.001).
  • [ISSN] 1755-8794
  • [Journal-full-title] BMC medical genomics
  • [ISO-abbreviation] BMC Med Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2633354
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100. Scalcione LR, Katz DS, Santoro MS, Mahboob S, Badler RL, Yung EY: Primary testicular lymphoma involving the spermatic cord and gonadal vein. Clin Nucl Med; 2009 Apr;34(4):222-3
MedlinePlus Health Information. consumer health - Testicular Cancer.

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  • [Title] Primary testicular lymphoma involving the spermatic cord and gonadal vein.
  • We report a case of a 70-year-old man with a history of prostatic adenocarcinoma and a 3-month history of right hemiscrotal swelling.
  • Scrotal ultrasound revealed a heterogeneous right testicular mass.
  • Subsequent right radical orchiectomy and pathologic examination revealed a B-cell lymphoma, infiltrating the testicular parenchyma, spermatic cord, gonadal vessels, and adjacent soft-tissues.
  • [MeSH-major] Lymphoma / diagnosis. Lymphoma / radionuclide imaging. Spermatic Cord / pathology. Testicular Neoplasms / diagnosis. Testicular Neoplasms / radionuclide imaging. Testis / blood supply. Veins / pathology

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  • (PMID = 19300051.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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