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1. Bahl A, Sharma DN, Julka PK, Das A, Rath GK: Sweat gland carcinoma with lung metastases. J Cancer Res Ther; 2006 Oct-Dec;2(4):209-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sweat gland carcinoma with lung metastases.
  • Sweat gland carcinoma is a rare skin tumor.
  • We report here a case of sweat gland carcinoma with bilateral lung metastases.
  • [MeSH-major] Carcinoma, Skin Appendage / secondary. Lung Neoplasms / secondary. Sweat Gland Neoplasms / pathology

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  • (PMID = 17998708.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents; YL5FZ2Y5U1 / Methotrexate
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2. Krishnamurthy J, Patil B: Aggressive digital papillary adenocarcinoma diagnosed by fine needle aspiration cytology. J Cytol; 2010 Jul;27(3):109-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive digital papillary adenocarcinoma diagnosed by fine needle aspiration cytology.
  • Aggressive digital papillary adenocarcinoma is a rare variant of eccrine sweat gland malignancy with a propensity for metastases and recurrence.
  • We report a 45-year-old female with aggressive digital papillary adenocarcinoma diagnosed by fine needle aspiration cytology (FNAC).
  • The recognition of aggressive digital papillary adenocarcinoma as a distinct clinicopathological eccrine sweat gland neoplasm is important because of the potential for aggressive local growth and distant metastasis.
  • FNAC plays an important role in the preoperative diagnosis and management of these lesions.

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  • (PMID = 21187879.001).
  • [ISSN] 0974-5165
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2983077
  • [Keywords] NOTNLM ; Aggressive digital papillary adenocarcinoma / eccrine sweat gland tumor / fine needle aspiration cytology
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3. Drut R, Giménez OP, Oliva J: Small cell sweat gland carcinoma of childhood. J Clin Pathol; 2005 Dec;58(12):1328-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small cell sweat gland carcinoma of childhood.
  • Small cell sweat gland carcinoma appears to represent a very unusual histological type of sweat gland anlage tumour presenting in children.
  • The differential diagnosis from other small blue cell tumours involving the skin is often difficult.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Child, Preschool. Diagnosis, Differential. Female. Humans. Male. Prognosis

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  • (PMID = 16311358.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC1770808
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4. Rafee A, Prasad G, Phang S, Ramesh P: Aggressive digital papillary adenocarcinoma of the hand. J Hand Surg Eur Vol; 2007 Jun;32(3):275-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive digital papillary adenocarcinoma of the hand.
  • This paper reports the case of a 26-year-old Caucasian male with an aggressive digital papillary adenocarcinoma of his right index finger.
  • Aggressive digital papillary adenocarcinoma is a rare tumour arising from sweat glands which occurs characteristically on the hands, fingers and toes.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Hand. Soft Tissue Neoplasms / surgery

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  • (PMID = 17306428.001).
  • [ISSN] 1753-1934
  • [Journal-full-title] The Journal of hand surgery, European volume
  • [ISO-abbreviation] J Hand Surg Eur Vol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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5. Tannous ZS, Avram MM, Zembowicz A, Mihm MC, Liteplo M, Kwan T, Olbricht SM: Treatment of synchronous mucinous carcinoma and endocrine mucin-producing sweat gland carcinoma with Mohs' micrographic surgery. Dermatol Surg; 2005 Mar;31(3):364-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of synchronous mucinous carcinoma and endocrine mucin-producing sweat gland carcinoma with Mohs' micrographic surgery.
  • BACKGROUND: Endocrine mucin-producing sweat gland carcinoma is a very rare cutaneous tumor that has been reported only in three patients previously.
  • We report a case of an endocrine mucin-producing sweat gland carcinoma associated with mucinous carcinoma treated by Mohs' micrographic surgery.
  • METHODS: A 79-year-old female with a 2-year history of four lesions of biopsy-proven endocrine mucin-producing sweat gland carcinomas and mucinous carcinoma was treated with Mohs' micrographic surgery.
  • CONCLUSION: Mohs' micrographic surgery is an appropriate treatment for mucinous carcinomata, including endocrine mucin-producing sweat gland carcinoma and mucinous carcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Mohs Surgery. Neoplasms, Multiple Primary / surgery. Orbital Neoplasms / surgery. Sweat Gland Neoplasms / surgery

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  • (PMID = 15841644.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Bazil MK, Henshaw RM, Werner A, Lowe EJ: Aggressive Digital Papillary Adenocarcinoma in a 15-year-old Female. J Pediatr Hematol Oncol; 2006 Aug;28(8):529-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive Digital Papillary Adenocarcinoma in a 15-year-old Female.
  • Aggressive digital papillary adenocarcinoma is a rare neoplasm of eccrine sweat gland origin that typically presents as a mass on a finger, toe, or the adjacent skin.
  • We report a case of an aggressive digital papillary adenocarcinoma of the right second toe in a 15-year-old white female.
  • To our knowledge, this is the youngest reported case of an aggressive digital papillary adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Fingers / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Humans. Rare Diseases. Sentinel Lymph Node Biopsy / methods

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  • (PMID = 16912593.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Chintamani, Rekhi B, Bansal A, Bhatnagar D, Saxena S: Expression of E-Cadherin in breast carcinomas and its association with other biological markers - a prospective study. Indian J Surg Oncol; 2010 Jan;1(1):40-6
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  • CONTEXT: E-cadherin (E-CD) is an important cell adhesion molecule in normal epithelial cells and has been shown to be an invasion tumor suppressor gene.
  • Present study reveals E-CD expression in 65 cases of breast cancer including 41 (63%) cases of pure infiltrating ductal carcinoma (IDC), 11 (16.9%) of pure infiltrating lobular carcinoma (ILC); another 10 (15.3%) of mixed ductal/lobular type, and remaining 3 (4.6%) miscellaneous types.
  • Both cases of comedo carcinoma revealed negative expression.
  • Invasive cribriform and medullary carcinoma revealed a stronger expression, while negative staining was observed in sweat gland carcinoma.

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  • (PMID = 22930617.001).
  • [ISSN] 0975-7651
  • [Journal-full-title] Indian journal of surgical oncology
  • [ISO-abbreviation] Indian J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3420990
  • [Keywords] NOTNLM ; Breast carcinomas / E-cadherin / Immunohistochemistry
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8. Al Baghli A, Reddy SS, Reddy MA: Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor. Middle East Afr J Ophthalmol; 2010 Oct;17(4):374-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor.
  • We report a case of malignant nodular hidradenoma in a middle-aged man, who presented with a nodular swelling in the eyelid.
  • Malignant forms of hidradenomas are unusual and the possibility this variant should be considered in the differential diagnosis of eyelid tumors.

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  • (PMID = 21180442.001).
  • [ISSN] 0975-1599
  • [Journal-full-title] Middle East African journal of ophthalmology
  • [ISO-abbreviation] Middle East Afr J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2991459
  • [Keywords] NOTNLM ; Eccrine Glands / Nodular Hidradenoma / Sweat Gland Tumor
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9. Emanuel PO, de Vinck D, Waldorf HA, Phelps RG: Recurrent endocrine mucin-producing sweat gland carcinoma. Ann Diagn Pathol; 2007 Dec;11(6):448-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent endocrine mucin-producing sweat gland carcinoma.
  • Endocrine mucin-producing sweat gland carcinoma is a rare skin tumor that most commonly involves the eyelid of elderly women.
  • Morphologically and immunohistochemically, it is analogous to endocrine ductal carcinoma in situ of the breast and mammary solid papillary carcinoma; also, like the analogous breast lesion, there is an often associated invasive mucinous carcinoma with neuroendocrine differentiation.
  • We describe the case of a 65-year-old woman with endocrine mucin-producing sweat gland carcinoma of the eyelid that recurred 3 years after an apparently complete excision.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Eyelid Neoplasms / pathology. Mucins / biosynthesis. Neoplasm Recurrence, Local / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18022131.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
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10. Nishimoto J, Amoh Y, Niiyama S, Takasu H, Katsuoka K: Aggressive digital papillary adenocarcinoma on the palm with pulmonary metastases. J Dermatol; 2008 Jul;35(7):468-70
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  • [Title] Aggressive digital papillary adenocarcinoma on the palm with pulmonary metastases.
  • A 41-year-old Japanese male had aggressive digital papillary adenocarcinoma with pulmonary metastases.
  • Two years after the lesion was removed, pulmonary nodular lesions were found on chest X-ray.
  • On histopathological examination, the pulmonary biopsy specimens showed lobular proliferation of acantholytic tumor cells and some ductal structures associated with papillary projections.
  • The tumor was diagnosed as an aggressive digital papillary adenocarcinoma.
  • This report is a rare case of aggressive digital papillary adenocarcinoma that was diagnosed based on the histopathology of the pulmonary metastases, which showed ductal structures associated with papillary projections.
  • [MeSH-major] Adenocarcinoma, Papillary / secondary. Lung Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 18705837.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. Gorva AD, Mohil R, Srinivasan MS: Aggressive digital papillary adenocarcinoma presenting as a paronychia of the finger. J Hand Surg Br; 2005 Oct;30(5):534

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive digital papillary adenocarcinoma presenting as a paronychia of the finger.
  • Aggressive digital papillary adenocarcinoma is a rare skin adnexal tumour, which has a predilection for the digits.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Fingers / pathology. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Paronychia / diagnosis

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  • (PMID = 16055244.001).
  • [ISSN] 0266-7681
  • [Journal-full-title] Journal of hand surgery (Edinburgh, Scotland)
  • [ISO-abbreviation] J Hand Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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12. Mehta S, Thiagalingam S, Zembowicz A, Hatton MP: Endocrine mucin-producing sweat gland carcinoma of the eyelid. Ophthal Plast Reconstr Surg; 2008 Mar-Apr;24(2):164-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endocrine mucin-producing sweat gland carcinoma of the eyelid.
  • The lesion was excised and pathology showed it to be endocrine mucin-producing sweat gland carcinoma with positive margins.
  • Clinicians should be aware of this entity given its association with invasive mucinous adenocarcinoma, a locally aggressive tumor with metastatic potential.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Eyelid Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18356733.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromogranins
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13. Hou JL, Wu LY, Zhang HT, Lv NN, Huang Y, Yu GZ: Clinicopathologic characteristics of 12 patients with vulvar sweat gland carcinoma. Int J Gynecol Cancer; 2010 Jul;20(5):874-8
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  • [Title] Clinicopathologic characteristics of 12 patients with vulvar sweat gland carcinoma.
  • OBJECTIVES: The aim of this article was to evaluate the clinical and pathologic characteristics, therapy, and prognostic factors of vulvar sweat gland carcinoma.
  • MATERIALS: Clinical and pathologic data for 12 patients with vulvar sweat gland carcinoma treated at our institution from January 1958 to April 2009 were retrospectively analyzed.
  • Of the 12 cases, 7 cases were vulvar sweat gland carcinoma, 3 cases were vulvar Paget disease with underlying sweat gland adenocarcinoma, 1 case was vulvar apocrine adenocarcinoma, and 1 case was adenoid cystic carcinoma of the vulvar sweat gland.
  • CONCLUSIONS: Vulvar sweat gland carcinoma is a very rare entity.
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Vulvar Neoplasms / diagnosis

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  • (PMID = 20606537.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Iijima M, Nakayama J, Nishizawa T, Ishida A, Ishii K, Ota H, Katsuyama T, Saida T: Usefulness of monoclonal antibody HIK1083 specific for gastric O-glycan in differentiating cutaneous metastasis of gastric cancer from primary sweat gland carcinoma. Am J Dermatopathol; 2007 Oct;29(5):452-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Usefulness of monoclonal antibody HIK1083 specific for gastric O-glycan in differentiating cutaneous metastasis of gastric cancer from primary sweat gland carcinoma.
  • Distinguishing cutaneous metastasis of gastric cancer from primary sweat gland carcinoma can be problematic in some cases, especially with a single lesion.
  • Previously we showed that a monoclonal antibody HIK1083 directed to alpha1,4-GlcNAc-capped O-glycans expressed in gastric gland mucin reacts to gastric cancer cells.
  • By contrast, it was reported that immunohistochemistry for cytokeratin 20 (CK20) may be helpful in the differential diagnosis between cutaneous metastasis of gastric cancer and primary sweat gland carcinoma.
  • Here, we immunohistochemically examined the expression of alpha1,4-GlcNAc-capped O-glycans and CK20 in 7 primary sweat gland carcinomas, 7 cutaneous metastases of gastric cancer, and 21 cutaneous metastases of other origin including breast, lung, colorectum, prostate, thyroid and pancreas using HIK1083 and CK20-specific Ks 20.8 antibodies and then assessed the usefulness of these antibodies in distinguishing cutaneous metastases of gastric cancer from primary sweat gland carcinoma and other cutaneous metastatic tumors.
  • Both alpha1,4-GlcNAc-capped O-glycans and CK20 were positive in 5 of 7 cases of cutaneous metastases of gastric cancer, while neither alpha1,4-GlcNAc-capped O-glycans nor CK20 were detected in any of the primary sweat gland carcinomas.
  • By contrast, alpha1,4-GlcNAc-capped O-glycans was not detected in any of the cutaneous metastases other than that of gastric cancer, whereas CK20 was detected in cutaneous metastases of colorectal cancer (2/2), breast cancer (2/13), and lung adenocarcinoma (1/3).
  • These findings indicate that immunohistochemistry using HIK1083 antibody is superior to immunohistochemistry for CK20 in distinguishing cutaneous metastasis of gastric cancer from primary sweat gland carcinomas and other cutaneous metastases.
  • [MeSH-major] Adenocarcinoma / secondary. Antibodies, Monoclonal. Polysaccharides / metabolism. Skin Neoplasms / secondary. Stomach / metabolism. Stomach Neoplasms / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-20 / metabolism. Male. Middle Aged

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  • (PMID = 17890913.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Keratin-20; 0 / Polysaccharides
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15. Mangrulkar VH, Gould ES, Miller F: Digital papillary adenocarcinoma: a case report. Hand Surg; 2006;11(1-2):51-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Digital papillary adenocarcinoma: a case report.
  • Digital papillary adenocarcinoma (DPAc) is a relatively rare neoplasm arising from the sweat glands with a predilection for the hand.
  • Our paper recommends specific consideration of DPAc in evaluating digital soft tissue masses, particularly those that present with an aggressive nature.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Fingers. Sweat Gland Neoplasms / pathology

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  • (PMID = 17080529.001).
  • [ISSN] 0218-8104
  • [Journal-full-title] Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand
  • [ISO-abbreviation] Hand Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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16. Swinson B, Ryan F, Barrett AW, Jerjes W, Landon G, Calonje E, Kalavrezos N: Histiocytoid eccrine sweat gland carcinoma of the eyelid: report of a case. Clin Exp Dermatol; 2006 Nov;31(6):786-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histiocytoid eccrine sweat gland carcinoma of the eyelid: report of a case.
  • This report describes the 12th documented case of histiocytoid, diffuse or signet-ring cell eccrine sweat gland carcinoma of the eyelid, a rare neoplasm that characteristically affects older men and mimics distant metastasis.
  • The features were reminiscent of both the histiocytoid and lobular variants of breast carcinoma.
  • Ultrastructurally, the presence of nonintestinal type microvilli with a length : width ratio in excess of 16 were consistent with an eccrine origin, but also raised the possibility of metastatic mesothelioma.
  • [MeSH-major] Eccrine Glands. Eyelid Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Aged. Colonic Neoplasms / pathology. Diagnosis, Differential. Humans. Male

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  • (PMID = 16869823.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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17. Heidemann W, Kasper HU, Gerlach KL: [Mucinous sweat gland carcinoma of a toe with metastasis to the maxilla. A case report]. Pathologe; 2005 May;26(3):221-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mucinous sweat gland carcinoma of a toe with metastasis to the maxilla. A case report].
  • Malignant tumors of the maxilla are rare.
  • Renal cell carcinomas, carcinomas of the breast, lung and adenocarcinomas are constituting the most frequent primary lesions for maxillary metastases.
  • To the best of our knowledge, we present the first case of a mucinous sweat gland carcinoma metastasizing to the maxilla four years after primary diagnosis.
  • Although skin tumors only rarely develop distant metastases, sweat gland carcinomas should be included in the differential diagnosis of tumors metastasizing to the maxilla.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Maxillary Neoplasms / secondary. Sweat Gland Neoplasms / pathology. Toes

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  • (PMID = 15290089.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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18. Zembowicz A, Garcia CF, Tannous ZS, Mihm MC, Koerner F, Pilch BZ: Endocrine mucin-producing sweat gland carcinoma: twelve new cases suggest that it is a precursor of some invasive mucinous carcinomas. Am J Surg Pathol; 2005 Oct;29(10):1330-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endocrine mucin-producing sweat gland carcinoma: twelve new cases suggest that it is a precursor of some invasive mucinous carcinomas.
  • Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is an underrecognized low-grade carcinoma with predilection to the eyelid.
  • Histologically, they were well-circumscribed, typically multinodular tumors with solid or partially cystic nodules, frequently showing areas of papillary architecture.
  • Calponin, smooth muscle actin, and p63 immunohistochemical stains did not disclose myoepithelial cells around larger tumor nests in most cases, supporting the notion that EMPSGC is an invasive carcinoma.
  • In 10 cases, cystic areas lined by benign epithelium indistinguishable from eccrine ducts were present.
  • In some foci, the benign ductal epithelium was undermined or replaced by carcinoma in situ with similar cytologic features to the solid or papillary areas of EMPSGC.
  • Myoepithelial cells were preserved in the areas of in situ carcinoma.
  • In 6 cases, EMPSGC was associated with invasive mucinous carcinoma.
  • In situ carcinoma and mucinous carcinoma also expressed neuroendocrine markers.
  • Clinical follow-up showed no recurrences or metastases, consistent with low-grade carcinoma.
  • The series provides histologic evidence for a multistage progression of noninvasive sweat gland neuroendocrine carcinoma to EMPSGC and then to mucinous carcinoma of the eyelid.
  • Although the data from this series support the notion that the prognosis of EMPSGC and mucinous carcinoma is good, longer follow-up is needed for better understanding of their pathogenesis and clinical behavior.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16160476.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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19. Frey J, Shimek C, Woodmansee C, Myers E, Greer S, Liman A, Adelman C, Rasberry R: Aggressive digital papillary adenocarcinoma: a report of two diseases and review of the literature. J Am Acad Dermatol; 2009 Feb;60(2):331-9
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for aggressive digital papillary adenocarcinoma .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive digital papillary adenocarcinoma: a report of two diseases and review of the literature.
  • Aggressive digital papillary adenocarcinoma (ADPAca) is a rare, underreported, and often misdiagnosed malignant tumor of the sweat glands most commonly occurring in males in their fifties to seventies.
  • These cases highlight both the importance of high clinical suspicion of digital tumors, even in children, enabling prompt diagnosis and treatment and also emphasize the metastatic potential of the tumor and the need for aggressive treatment and close long-term follow-up.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / surgery. Fingers. Sweat Gland Neoplasms / pathology. Sweat Gland Neoplasms / surgery

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  • (PMID = 18819728.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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20. Keramidas EG, Miller G, Revelos K, Kitsanta P, Page RE: Aggressive digital papillary adenoma-adenocarcinoma. Scand J Plast Reconstr Surg Hand Surg; 2006;40(3):189-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive digital papillary adenoma-adenocarcinoma.
  • Aggressive digital papillary adenocarcinoma and aggressive digital papillary adenoma are rare tumours of the sweat glands.

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  • (PMID = 16687341.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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21. Wosnitza M, Rübben A, Pallua N, Megahed M: [Eccrine adenocarcinoma in a patient with familial breast carcinoma]. Hautarzt; 2008 Nov;59(11):879-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Eccrine adenocarcinoma in a patient with familial breast carcinoma].
  • The histopathologic findings showed eccrine adenocarcinoma, a member of the heterogeneous group of sweat gland tumors which occur primarily in adults with a peak of 50-60 years of age.
  • Sweat gland carcinomas are extremely rare neoplasms of the skin and exhibit a slow growth rate with a rather high local recurrence rate.
  • Nevertheless there are some case reports on successful therapy of a metastasized sweat gland carcinoma with 5-fluorouracil and tamoxifen.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Eccrine Glands / pathology. Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / secondary

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  • (PMID = 18931983.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Analgesics; 094ZI81Y45 / Tamoxifen
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22. Hsu HC, Ho CY, Chen CH, Yang CH, Hong HS, Chuang YH: Aggressive digital papillary adenocarcinoma: a review. Clin Exp Dermatol; 2010 Mar;35(2):113-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive digital papillary adenocarcinoma: a review.
  • Vigorous treatment of aggressive digital papillary adenocarcinoma (ADPA), including amputation, has been recommended by most authors, but the appropriateness and effectiveness of excision as an alternative to amputation has not been systematically evaluated.
  • [MeSH-major] Adenocarcinoma, Papillary. Amputation. Skin Neoplasms


23. Bannur HB, Mastiholimath RD, Malur PR: Primary mucinous eccrine adenocarcinoma of the scalp: a case report. Acta Cytol; 2009 Nov-Dec;53(6):698-700

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mucinous eccrine adenocarcinoma of the scalp: a case report.
  • BACKGROUND: Lesions of primary mucinous carcinoma of the skin present as painless, papular or nodular masses with sizes ranging from 5 mm to 120 mm.
  • Metastatic deposits from undiagnosed visceral and breast adenocarcinoma are virtually indistinguishable microscopically from sweat gland carcinoma and must be considered before a diagnosis of sweat gland carcinoma is made.
  • Fine needle aspiration cytology of the lesion showed malignant cells in a mucoid background.
  • A diagnosis of mucinous eccrine adenocarcinoma was given.
  • CONCLUSION: Primary mucinous adenocarcinoma of the skin is a rare tumor and mimics metastatic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Eccrine Glands / pathology. Scalp / pathology

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  • (PMID = 20014562.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Chi CC, Kuo TT, Wang SH: Aggressive digital papillary adenocarcinoma: a silent malignancy masquerading as acquired digital fibrokeratoma. Am J Clin Dermatol; 2007;8(4):243-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive digital papillary adenocarcinoma: a silent malignancy masquerading as acquired digital fibrokeratoma.
  • Aggressive digital papillary adenocarcinoma (ADPAC) is a rare cutaneous malignant tumor.
  • The lesion clinically resembled an acquired digital fibrokeratoma, but was found to be an ADPAC after pathologic study of the excised specimens.
  • ADPAC should be suspected with an indolent digital tumor even without any clinical change or symptom for years.
  • An excisional biopsy is warranted for correct diagnosis.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Immunohistochemistry. Keratosis / diagnosis. Male. Thumb / pathology

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  • (PMID = 17645380.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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25. Zelger BG, Stelzmueller I, Dunst KM, Zelger B: Solid apocrine carcinoma of the skin: report of a rare adnexal neoplasm mimicking lobular breast carcinoma. J Cutan Pathol; 2008 Mar;35(3):332-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid apocrine carcinoma of the skin: report of a rare adnexal neoplasm mimicking lobular breast carcinoma.
  • The so called 'sweat gland carcinoma' is a rare skin malignancy.
  • The differentiation between apocrine and eccrine neoplasms remains difficult.
  • A 71-year-old man presented with a morphea-like plaque of the right axilla which in punch biopsy was first suspected as metastasis of primary lobular breast carcinoma.
  • After further clinical and laboratory work up including immunohistochemistry the original diagnosis of a breast cancer had to be changed to solid apocrine carcinoma of the skin.
  • Solid apocrine carcinoma of the skin is a rare variant with apocrine differentiation.
  • A survey of the stereotypical presentation of this lesion and a comparison with lobular breast carcinoma and other types of apocrine carcinoma of the skin is given.
  • [MeSH-major] Adenocarcinoma / diagnosis. Apocrine Glands / pathology. Breast Neoplasms, Male / diagnosis. Carcinoma, Lobular / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Disease-Free Survival. Humans. Immunohistochemistry. Male

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  • (PMID = 18251751.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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26. DePond W, Kure K, Lankachandra K, Gidwani R, Nelson BV, Zimmerman H, Talboy GE Jr, Miranda RN: Human papillomavirus-58 and -73-associated digital squamous cell carcinoma in a patient with aggressive digital papillary adenocarcinoma. Am J Dermatopathol; 2009 Jun;31(4):375-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus-58 and -73-associated digital squamous cell carcinoma in a patient with aggressive digital papillary adenocarcinoma.
  • Aggressive digital papillary adenocarcinoma (ADPA) is a rare tumor that is considered to arise from eccrine sweat glands of the skin.
  • Prompt diagnosis and regular follow-up are important to ensure the best possible outcome.
  • We discuss a case of recurrent ADPA associated with subsequent squamous cell carcinoma (SCC) in different contralateral digits in a 55-year-old man.
  • HPV-associated digital SCCs have been reported; most cases are HPV-16 positive.
  • This report describes a rare case of an HPV-58-positive invasive digital SCC and an HPV-73-positive SCC in situ associated with ADPA.
  • [MeSH-major] Adenocarcinoma, Papillary / virology. Carcinoma, Squamous Cell / virology. Papillomaviridae / isolation & purification. Papillomavirus Infections / pathology. Skin Neoplasms / virology
  • [MeSH-minor] Biopsy. Carcinoma in Situ / pathology. Carcinoma in Situ / virology. Fingers / pathology. Fingers / virology. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / virology

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  • (PMID = 19461243.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Bhattacharjee PK, Ghosh G, Bhattacharya D, Banerjee S: Sweat gland carcinoma - a case report. J Indian Med Assoc; 2010 Dec;108(12):871-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sweat gland carcinoma - a case report.
  • It showed adenocarcinoma of the sweat glands.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / therapy

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  • (PMID = 21661469.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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28. Bulliard C, Murali R, Maloof A, Adams S: Endocrine mucin-producing sweat gland carcinoma: report of a case and review of the literature. J Cutan Pathol; 2006 Dec;33(12):812-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endocrine mucin-producing sweat gland carcinoma: report of a case and review of the literature.
  • Mucinous carcinoma of skin (MCS) is an uncommon adnexal tumor of disputed differentiation.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Eyelid Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17177942.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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29. Rütten A, Requena L: [Sweat gland carcinomas of the skin]. Hautarzt; 2008 Feb;59(2):151-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sweat gland carcinomas of the skin].
  • Sweat gland carcinomas are rare malignant tumors of the skin.
  • The well-defined entities porocarcinoma, microcystic adnexal carcinoma, aggressive digital papillary adenocarcinoma, mucinous eccrine carcinoma, adenoid cystic carcinoma, spiradenocarcinoma, cylindrocarcinoma, hidradenocarcinoma are described.
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / therapy

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  • [Cites] Br J Dermatol. 2000 Apr;142(4):688-93 [10792218.001]
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  • (PMID = 18214401.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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30. Pai RR, Kini JR, Achar C, Rau A, Kini H: Apocrine (cutaneous) sweat gland carcinoma of axilla with signet ring cells: a diagnostic dilemma on fine-needle aspiration cytology. Diagn Cytopathol; 2008 Oct;36(10):739-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine (cutaneous) sweat gland carcinoma of axilla with signet ring cells: a diagnostic dilemma on fine-needle aspiration cytology.
  • Carcinoma arising in the apocrine sweat glands is rare and there are few reports describing the cytological features of this neoplasm.
  • We describe the cytological features of a histologically confirmed apocrine carcinoma occurring in a 55-year-old man who presented with an ulcerated mass in the right axilla.
  • Fine-needle aspiration cytology revealed features of a signet ring adenocarcinoma.
  • In an axillary mass lesion, cytological features along with clinical correlation are essential to distinguish primary apocrine carcinoma from mammary neoplasms with signet ring cells and other metastatic adenocarcinomas.
  • [MeSH-major] Axilla. Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / pathology. Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Biopsy, Fine-Needle / methods. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 18773442.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Gangane N, Joshi D, Sharma SM: Cytomorphological diagnosis of malignant eccrine tumors: report of two cases. Diagn Cytopathol; 2008 Nov;36(11):801-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphological diagnosis of malignant eccrine tumors: report of two cases.
  • We hereby describe the cytological features of two histologically confirmed cases of malignant eccrine tumors.
  • A cytological diagnosis of low grade papillary adenocarcinoma arising from skin adnexal structures was given in case number 1.
  • Aspirate from case number 2 was reported as positive for malignant cells, and histological examination was advised.
  • Histological examination revealed the presence of malignant eccrine acrospiroma in case number 1 and papillary digital adenocarcinoma in case number 2.
  • Careful cytological examination displayed the characteristic of two cell population seen in eccrine tumors in both the cases.
  • Diagnosis of malignant eccrine tumors cannot be made with certainity on cytology alone, hence the need to document the cytological features of these entities is emphasized.
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Cell Aggregation. Cell Nucleus / pathology. Female. Humans. Male. Middle Aged

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  • (PMID = 18831018.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Segal A, Segal N, Gal A, Tumuluri K: Mucinous sweat gland adenocarcinoma of the eyelid - current knowledge of a rare tumor. Orbit; 2010 Dec;29(6):334-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous sweat gland adenocarcinoma of the eyelid - current knowledge of a rare tumor.
  • PURPOSE: To review the medical literature on mucinous sweat gland adenocarcinoma of the eyelid (MSA) and present two new cases.
  • In 12(21.8%) patients a lesion with a benign diagnosis was previously excised from the same location.
  • In 2 of them histological re-examination resulted in a diagnosis of MSA.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Eyelid Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 21158574.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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33. Toulemonde A, Croue A, Rodien P, Verret JL: [Malignant nodular hidradenoma and multiple nodular hidradenomas in a hypogonadic patient]. Ann Dermatol Venereol; 2006 Dec;133(12):1005-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant nodular hidradenoma and multiple nodular hidradenomas in a hypogonadic patient].
  • BACKGROUND: We report a case of multiple benign nodular hidradenomas associated with malignant nodular hidradenoma in a hypogonadic patient.
  • CASE-REPORT: A 49 year-old man presented 11 benign nodular hidradenomas in the pectoral region.
  • A malignant nodular hidradenoma had recently appeared in this region some distance from the pre-existing benign modular hidradenomas.
  • Large numbers of estrogen receptors were demonstrated in each of the benign nodular hidradenomas.
  • The malignant nodular hidradenoma mass was unavailable and screening for these receptors was not possible.
  • DISCUSSION: Cases of multiple nodular hidradenoma are extremely rare: we have seen only two.
  • To the best of our knowledge, there have been no reports to date of combined malignant nodular hidradenoma and multiple benign nodular hidradenoma.
  • However, the presence of estrogen receptors has occasionally been demonstrated in benign nodular hidradenomas.
  • [MeSH-major] Adenoma, Sweat Gland / complications. Hypogonadism / complications. Sweat Gland Neoplasms / complications

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  • (PMID = 17185934.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Receptors, Estrogen
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34. Tu H, Han H, Zhou FJ, Li YH, Qin ZK, Liu ZW: [Extramammary Paget's disease of the scrotum with underlying sweat gland adenocarcinoma: a report of six cases with literature review]. Ai Zheng; 2009 Aug;28(8):879-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extramammary Paget's disease of the scrotum with underlying sweat gland adenocarcinoma: a report of six cases with literature review].
  • BACKGROUND AND OBJECTIVE: Extramammary Paget's disease (EMPD) of the scrotum with sweat gland adenocarcinoma is a rare malignant tumor.
  • This study was to summarize the clinicopathologic characteristics of scrotum Paget's disease with underlying sweat gland adenocarcinoma, and analyze the treatment outcome.
  • METHODS: Clinical data of six scrotum Paget's disease patients with sweat gland adenocarcinoma, treated in Sun Yat-sen University Cancer Center from 1964 to 2004, were analyzed with literature review.
  • RESULTS: The typical manifestation of scrotum Paget's disease with sweat gland adenocarcinoma was eczematoid-like skin changes.
  • CONCLUSION: The primary lesion resection plus uni-inguinal lymphadenectomy is the major treatment for scrotum Paget's disease with underlying sweat gland adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Genital Neoplasms, Male / surgery. Neoplasms, Multiple Primary / surgery. Paget Disease, Extramammary / surgery. Sweat Gland Neoplasms / surgery

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  • (PMID = 19664337.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
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35. Grin A, Colgan T, Laframboise S, Shaw P, Ghazarian D: "Pagetoid" eccrine carcinoma of the vulva: report of an unusual case with review of the literature. J Low Genit Tract Dis; 2008 Apr;12(2):134-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] "Pagetoid" eccrine carcinoma of the vulva: report of an unusual case with review of the literature.
  • Sweat gland carcinoma of the vulva is rare and may be classified as being of eccrine, apocrine, or mixed origin.
  • Most reported cases of vulvar sweat gland carcinomas associated with extramammary Paget disease describe a tumor of apocrine origin.
  • We report a case of a vulvar sweat gland carcinoma of eccrine origin associated with Pagetoid extension.
  • A review of the literature and the differential diagnosis are also presented.
  • To our knowledge, this is the second case of vulvar sweat gland carcinoma of eccrine origin associated with extramammary Paget disease.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Sweat Gland Neoplasms / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Female. Gynecologic Surgical Procedures / methods. Humans. Lymph Node Excision. Paget Disease, Extramammary / diagnosis. Pelvis

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  • (PMID = 18369309.001).
  • [ISSN] 1526-0976
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Ying J, Yao DH, Cheng KX, Ren XM, Shu MJ, Yao HJ: [Reconstruction of extended skin defect after the radical resection procedure for penile scrotum skin cancer]. Zhonghua Wai Ke Za Zhi; 2007 Sep 15;45(18):1257-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: To investigate the reconstruction of skin defect after extended resection of malignant skin tumor in or adjacent to the genitals, and to investigate the recovery of the function of urinary system and sexual intercourse after the operation.
  • METHODS: From February 1998 to August 2006, 17 patients with carcinoma of sweat gland or Paget's disease in or adjacent to the genitals were given standard radical resections including groin lymph node dissections.

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  • (PMID = 18067739.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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37. Asghar AH, Mahmood H, Faheem M, Rizvi S, Khan KA, Irfan J: Porocarcinoma: a rare sweat gland malignancy. J Coll Physicians Surg Pak; 2009 Jun;19(6):389-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Porocarcinoma: a rare sweat gland malignancy.
  • Eccrine Porocarcinoma (ECP) is a malignant tumour arising from the intraepithelial ductal parts of the sweat gland.
  • It has also been described as malignant hidroacanthoma simplex, sweat gland carcinoma, malignant intra-epidermal eccrine poroma, eccrine poroepithelioma, dysplastic poroma, malignant syringo acanthoma and porocarcinoma.
  • [MeSH-major] Acrospiroma / diagnosis
  • [MeSH-minor] Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Doxorubicin / therapeutic use. Humans. Male. Middle Aged. Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / drug therapy. Sweat Gland Neoplasms / surgery

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  • (PMID = 19486582.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin
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38. Souvatzidis P, Sbano P, Mandato F, Fimiani M, Castelli A: Malignant nodular hidradenoma of the skin: report of seven cases. J Eur Acad Dermatol Venereol; 2008 May;22(5):549-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant nodular hidradenoma of the skin: report of seven cases.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is an infrequent, highly malignant, primary skin tumour derived from eccrine sweat glands.
  • Histological parameters are paramount, but correct diagnosis also calls for attention to clinical presentation and any history of recurrence or recent enlargement of long-standing lesions.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 18410617.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 29
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39. Garcia-Bonafe MM, Campins MM, Redecilla PH: Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol; 2009 Sep-Oct;53(5):576-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant adnexal tumor of the eccrine sweat glands.
  • The histology is similar to that of benign nodular hidradenoma, but MNH shows an infiltrative and invasive pattern, necrosis and angiolymphatic invasion.
  • CASE: A 60-year-old woman, diagnosed with rectal adenocarcinoma 6 months before, underwent fine needle aspiration (FNA) of a nodule on the scalp.
  • (2) cohesive cell clusters and tissue fragments;.
  • (4) globoid or cylindrical clear cells;.
  • (6) cell sheets with anaplasia and squamous differentiation; and (7) multinucleated giant cells.
  • The clear cells that were seen on cytology occupied the periphery of the lobules, whereas the anaplastic cells were located in the central portion.
  • CONCLUSION: Rapid, accurate diagnosis of these tumors is important, particularly when they develop at sites where a metastatic process must be ruled out.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Biopsy, Fine-Needle. Head and Neck Neoplasms / pathology. Scalp / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Anaplasia. Cell Differentiation. Female. Giant Cells / pathology. Humans. Immunohistochemistry. Middle Aged. Necrosis. Neoplasm Invasiveness. Predictive Value of Tests

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  • (PMID = 19798887.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Shah BK, Qamruzzaman Y, Serban K, Hire E, Ying SC: First case report of locally advanced malignant nodular hidradenoma of the scrotum. Onkologie; 2010;33(12):701-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] First case report of locally advanced malignant nodular hidradenoma of the scrotum.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant tumor of the eccrine glands, and most commonly involves the head, trunk, and extremities.
  • [MeSH-major] Acrospiroma / pathology. Genital Neoplasms, Male / pathology. Scrotum / pathology. Sweat Gland Neoplasms / pathology

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 21124043.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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41. Singh A, Sharma S, Verma S, Khanna A: Malignant nodular hidradenoma with angiolymphatic invasion: a case report. Indian J Pathol Microbiol; 2007 Jul;50(3):548-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant nodular hidradenoma with angiolymphatic invasion: a case report.
  • Malignant nodular hidradenomas are rare variants of sweat gland carcinomas characterized by aggressive clinical behaviour.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17883130.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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42. Hatta N, Morita R, Yamada M, Takehara K, Ichiyanagi K, Yokoyama K: Implications of popliteal lymph node detected by sentinel lymph node biopsy. Dermatol Surg; 2005 Mar;31(3):327-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Fourteen patients with various skin cancers involving the lower extremities (nine melanomas, four squamous cell carcinomas, and one sweat gland carcinoma) underwent lymphoscintigraphy and excision with sentinel lymph node biopsy.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Melanoma / pathology. Sentinel Lymph Node Biopsy. Skin Neoplasms / pathology

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  • (PMID = 15841636.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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43. Fernández-Figueras MT, Montero MA, Admella J, de la Torre N, Quer A, Ariza A: High (nuclear) grade adnexal carcinoma with microcystic adnexal carcinoma-like structural features. Am J Dermatopathol; 2006 Aug;28(4):346-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High (nuclear) grade adnexal carcinoma with microcystic adnexal carcinoma-like structural features.
  • Microcystic adnexal carcinoma (MAC) is a slow growing, locally aggressive sweat gland tumor.
  • We report a case of adnexal carcinoma with architectural features of MAC that displayed also marked nuclear pleomorphism and hyperchromasia with squamous pearl formation and a widespread strong p53 immunoreaction.
  • We therefore want to sound an alert about the possible existence of tumors displaying microscopic findings characteristic of the aggressive forms of sweat gland carcinoma (nuclear pleomorphism and hyperchromasia, vascular invasion, and necrosis) in addition to architectural features of MAC.
  • [MeSH-major] Cell Nucleus / pathology. Lip Neoplasms / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Cell Shape. Fatal Outcome. Humans. Male. Neoplasm Staging. Osteosarcoma / pathology. Recurrence. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 16871041.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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44. Gauerke S, Driscoll JJ: Hidradenocarcinomas: a brief review and future directions. Arch Pathol Lab Med; 2010 May;134(5):781-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hidradenocarcinomas: a brief review and future directions.
  • Hidradenocarcinomas are rare, aggressive skin adnexal tumors of sweat gland origin that demonstrate a high potential for local recurrence, metastasis, and poor outcome.
  • These neoplasms can derive from preexisting clear cell hidradenomas but more commonly appear de novo, with the molecular events responsible for the pathogenesis currently unknown.
  • Historically, diagnosis has been difficult because of the few cases, inconsistent nomenclature, variable morphology of cells that compose the neoplasm, and confusion with other visceral metastatic tumors.
  • Future studies are required to identify the histopathologic and immunohistochemical features, which may facilitate diagnosis and foster development of molecularly targeted forms of adjuvant therapy.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Diagnosis, Differential. Humans. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 20441512.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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45. Bonadio J, Armstrong W, Gu M: Eccrine porocarcinoma: Report of a case with fine needle aspiration cytology, histopathology and immunohistochemistry. Acta Cytol; 2006 Jul-Aug;50(4):476-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine porocarcinoma: Report of a case with fine needle aspiration cytology, histopathology and immunohistochemistry.
  • BACKGROUND: Although relatively rare, eccrine porocarcinoma (EP) is widely recognized in the literature as the most common of the sweat gland adenocarcinoma types.
  • EP is an adenocarcinoma of the eccrine sweat gland with a propensity to recur locally and metastasize to regional lymph nodes.
  • FNA cytology potentially provides a convenient, safe and effective approach to solving a challenging differential diagnosis.
  • History is important in making an accurate diagnosis.
  • [MeSH-major] Carcinoma / pathology. Sweat Gland Neoplasms / pathology. Sweat Glands / pathology

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  • (PMID = 16901019.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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46. Miwa Y, Mochiduki M, Nakayama H, Shibuya N, Ogawa H, Sasaki N: Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit. J Small Anim Pract; 2006 Sep;47(9):541-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit.
  • The histopathological diagnosis of the mass was apocrine adenocarcinoma.
  • To the authors' knowledge, this report describes the first case of spontaneous apocrine adenocarcinoma of possible sweat gland origin in a male rabbit.
  • [MeSH-major] Adenocarcinoma / veterinary. Apocrine Glands / pathology. Rabbits. Sweat Gland Neoplasms / veterinary

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  • (PMID = 16961473.001).
  • [ISSN] 0022-4510
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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47. Morandi F, Benazzi C, Simoni P: Adenocarcinoma of apocrine sweat glands in a mouflon (Ovis musimon). J Vet Diagn Invest; 2005 Jul;17(4):389-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of apocrine sweat glands in a mouflon (Ovis musimon).
  • On the basis of histological and ultrastructural findings, this tumor was diagnosed as a tubulopapillary adenocarcinoma, arising from apocrine sweat glands of the skin.
  • [MeSH-major] Adenocarcinoma / veterinary. Apocrine Glands. Sheep Diseases / diagnosis. Sweat Gland Neoplasms / veterinary

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  • (PMID = 16131002.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Ward JL, Prieto VG, Joseph A, Chevray P, Kronowitz S, Sturgis EM: Neurothekeoma. Otolaryngol Head Neck Surg; 2005 Jan;132(1):86-9
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  • In addition, the pathology records of 6 patients reviewed by the Department of Pathology for diagnosis only were retrospectively reviewed.
  • Two lesions had been previously diagnosed, histologically, as leiomyosarcomas, 1 as a malignant nodular hidradenoma, and 1 as a clear cell hidradenoma.
  • Care must be taken in the pathologic diagnosis of cutaneous neoplasms, and neurothekeoma should be considered in the differential diagnosis for spindle cell lesions.

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  • (PMID = 15632914.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Cohen M, Cassarino DS, Shih HB, Abemayor E, St John M: Apocrine hidradenocarcinoma of the scalp: a classification conundrum. Head Neck Pathol; 2009 Mar;3(1):42-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine hidradenocarcinoma of the scalp: a classification conundrum.
  • INTRODUCTION: The classification of malignant sweat gland lesions is complex.
  • Traditionally, cutaneous sweat gland tumors have been classified by either eccrine or apocrine features.
  • RESULTS: Final pathology revealed an apocrine hidradenocarcinoma.
  • CONCLUSION: Apocrine hidradenocarcinoma can be viewed as an aggressive malignant lesion of cutaneous sweat glands on a spectrum that involves both eccrine and apoeccrine lesions.
  • [MeSH-major] Adenocarcinoma / classification. Apocrine Glands / pathology. Head and Neck Neoplasms / classification. Scalp / pathology. Sweat Gland Neoplasms / classification

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  • (PMID = 20596988.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807530
  • [Keywords] NOTNLM ; Apocrine / Eccrine / Head / Hidradenocarcinoma / Neck / Scalp / Sweat gland
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50. Ko CJ, Cochran AJ, Eng W, Binder SW: Hidradenocarcinoma: a histological and immunohistochemical study. J Cutan Pathol; 2006 Nov;33(11):726-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hidradenocarcinoma: a histological and immunohistochemical study.
  • The diagnosis of hidradenocarcinoma is difficult due to a combination of factors including inconsistent nomenclature/ classification, rarity of the neoplasm, and variable morphology of cells composing the neoplasm.
  • Immunohistochemistry has not been previously performed on a series of hidradenocarcinomas.
  • We evaluated six cases of hidradenocarcinoma histologically and immunohistochemically using antibodies to gross cystic disease fluid protein-15 (GCDFP-15), carcino-embryonic antigen (CEA), epithelial membrane antigen (EMA), S-100 protein, keratin AE1/3, cytokeratin 5/6, p53, bcl-1, bcl-2, and Ki67.
  • Histology suggested concurrent eccrine and apocrine differentiation of the cases.
  • In making the diagnosis of hidradenocarcinoma, it may be unnecessary to separate hidradenocarcinoma into eccrine and apocrine categories, and although Ki67 and p53 may be helpful, histological parameters remain paramount.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Ki-67 Antigen / metabolism. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17083691.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Proteins; 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1; 68238-35-7 / Keratins
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51. Kazakov DV, Ivan D, Kutzner H, Spagnolo DV, Grossmann P, Vanecek T, Sima R, Kacerovska D, Shelekhova KV, Denisjuk N, Hillen U, Kuroda N, Mukensnabl P, Danis D, Michal M: Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. Am J Dermatopathol; 2009 May;31(3):236-47
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  • [Title] Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation.
  • We present a series of 14 cases of cutaneous hidradenocarcinomas.
  • The patients included 6 women and 8 men ranging in age at diagnosis from 34 to 93 years.
  • The residuum of a hidradenoma was present in 5 of the 14 primaries.
  • The cellular composition of the tumors varied slightly, with clear cells, epidermoid cells, and transitional forms being present in each case.
  • In 1 case, there was metaplastic transformation into sarcomatoid carcinoma.
  • One specimen represented a reexcision and was unusual as it showed a well-demarcated intradermal proliferation of relatively bland clear cells accompanied by an overlying intraepidermal growth of clear cells resembling hidradenoacanthoma simplex.
  • Of 10 primaries studied, 4 tumors showed positive p53 immunoreaction in more than 25% of the cells comprising the malignant portion of the lesions, in 2 cases, a minority of the neoplastic cells (10%-20%) demonstrated nuclear staining, whereas the remaining 4 cases were negative.
  • Of 9 specimens of hidradenocarcinoma studied for TP53 mutations, 2 harbored mutations, whereas the remaining 7 specimens showed the wild-type sequence.
  • It is concluded that cutaneous hidradenocarcinomas show some microscopic heterogeneity and comprise both low- and high-grade lesions that cytologically are similar to their benign counterpart, the hidradenoma.
  • Similar to hidradenomas, hidradenocarcinomas show a t(11;19) translocation, but it is a significantly rarer event.
  • [MeSH-major] Adenocarcinoma / pathology. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. Gene Amplification. Mutation. Receptor, ErbB-2 / genetics. Sweat Gland Neoplasms / pathology. Translocation, Genetic. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation. Cell Proliferation. DNA Mutational Analysis. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged. Necrosis

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  • (PMID = 19384064.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
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52. Reyes CV: Clear cell hidradenocarcinoma developing in pacemaker pocket. Pacing Clin Electrophysiol; 2008 Nov;31(11):1513-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell hidradenocarcinoma developing in pacemaker pocket.
  • An octagenerian woman developed clear cell hidradenocarcinoma, a rare neoplasm of eccrine sweat gland origin, 4 years following pacemaker implantation in her right lateral chest.
  • The tumor immunohistochemically mimicked a metastatic lobular breast carcinoma, for example, strongly positive estrogen, weakly positive progesterone, and weakly reactive mammoglobin.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Clear Cell / etiology. Foreign-Body Reaction / diagnosis. Foreign-Body Reaction / etiology. Heart Neoplasms / diagnosis. Heart Neoplasms / etiology. Pacemaker, Artificial / adverse effects

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  • (PMID = 18950311.001).
  • [ISSN] 1540-8159
  • [Journal-full-title] Pacing and clinical electrophysiology : PACE
  • [ISO-abbreviation] Pacing Clin Electrophysiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Durairaj VD, Hink EM, Kahook MY, Hawes MJ, Paniker PU, Esmaeli B: Mucinous eccrine adenocarcinoma of the periocular region. Ophthal Plast Reconstr Surg; 2006 Jan-Feb;22(1):30-5
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  • [Title] Mucinous eccrine adenocarcinoma of the periocular region.
  • PURPOSE: To report 4 patients with mucinous eccrine adenocarcinoma of the periocular region.
  • METHODS: Interventional case series of 4 patients with mucinous eccrine adenocarcinoma of the periocular region treated at 2 centers.
  • RESULTS: Two patients with mucinous eccrine adenocarcinoma of the upper eyelid, 1 with mucinous eccrine adenocarcinoma of the lower eyelid, and 1 with mucinous eccrine adenocarcinoma of the eyebrow were included in this report.
  • CONCLUSIONS: Mucinous eccrine adenocarcinoma is a rare ocular adnexal neoplasm that can involve the eyelid and periocular skin, can be locally invasive, and has a high risk of local recurrence despite Mohs surgery.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Eyelid Neoplasms / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Middle Aged. Mohs Surgery / methods. Radiotherapy, Adjuvant

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  • (PMID = 16418662.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Motta M, Alongi F, De Martin E, Fiorino C, Maggiulli E, Rigoni L, Landoni C, Broggi S, Deli AM, Calandrino R, Di Muzio N: Helical tomotherapy for scalp recurrence of primary eccrine mucinous adenocarcinoma. Tumori; 2009 Nov-Dec;95(6):832-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Helical tomotherapy for scalp recurrence of primary eccrine mucinous adenocarcinoma.
  • Primary cutaneous mucinous carcinomas originating from sweat glands are rare tumors with patterns of spread that are difficult to predict.
  • We present a case of a five times recurring eccrine mucinous adenocarcinoma of the scalp, previously treated with surgery and adjuvant radiation therapy.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiotherapy. Head and Neck Neoplasms / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Sweat Gland Neoplasms / radiotherapy. Tomography, Spiral Computed

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  • (PMID = 20210254.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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55. Hernandez JM, Copeland EM 3rd: Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread. Am Surg; 2007 Mar;73(3):307-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread.
  • Apocrine adenocarcinoma is a rare malignancy with invasive potential.
  • Its clinical behavior and histologic appearance are highly variable, making accurate diagnosis difficult.
  • We report on a case of apocrine carcinoma presenting with lymph node infiltration and extensive extramammary Paget's disease.
  • [MeSH-major] Adenocarcinoma / pathology. Apocrine Glands. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Groin. Humans. Male. Neoplasm Invasiveness. Sentinel Lymph Node Biopsy

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  • (PMID = 17375797.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Piris A, Scopsi L, Clemente C, Cetti Serbelloni F, Mihm MC Jr, Hoang MP: Epidermal growth factor receptor gene status by fluorescence in situ hybridization in malignant, atypical, and benign hidradenomas. Am J Dermatopathol; 2010 Aug;32(6):586-92
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  • [Title] Epidermal growth factor receptor gene status by fluorescence in situ hybridization in malignant, atypical, and benign hidradenomas.
  • There is little information in the literature regarding the EGFR protein and gene status in hidradenocarcinomas which has an aggressive biologic course characterized by repeated local recurrences and systemic metastasis.
  • We have previously reported EGFR protein overexpression in malignant, atypical, and benign hidradenomas and would like to further evaluate their gene status by fluorescence in situ hybridization.
  • METHODS: Fluorescence in situ hybridization by 2-color probe Vysis LSI EGFR SpectrumOrange/CEP 7 SpectrumGreen Probe (Abbott Molecular) and EGFR immunostain (H11, Dakocytomation) were performed in 15 malignant, 15 atypical, and 7 benign hidradenomas.
  • RESULTS: High polysomy and low trisomy was noted in 1 and 4 hidradenocarcinoma, respectively; however, EGFR overexpression was seen only in 1 low trisomy case.
  • Disomy is noted in the remaining 29 cases (9 hidradenocarcinomas, 15 atypical hidradenomas, and 5 benign hidradenomas).
  • EGFR overexpression was seen in 3/12 (25%) malignant hidradenomas, 7/15 (47%) atypical hidradenomas, and 3/5 (60%) benign hidradenomas; none of these cases demonstrated EGFR gene amplification.
  • CONCLUSIONS: Polysomy/trisomy is more frequently seen in hidradenocarcinoma than atypical and benign hidradenomas.
  • The role of EGFR inhibitor therapy in hidradenocarcinoma cases with protein overexpression remains unclear.
  • Lack of correlation between the protein expression and polysomy/gene amplification suggests that molecular mechanisms other than gene amplification play a role in EGFR overexpression in malignant, atypical, and benign hidradenomas.
  • [MeSH-major] Acrospiroma / pathology. Adenocarcinoma / secondary. Gene Expression Regulation, Neoplastic. Receptor, Epidermal Growth Factor / genetics. Sweat Gland Neoplasms / genetics. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Cell Proliferation. Chromosome Aberrations. Gene Amplification. Humans. In Situ Hybridization, Fluorescence / methods. Lymph Nodes / pathology. Trisomy

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  • (PMID = 20534988.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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57. Leung TH, Lee HH, Chang SC: Perianal eccrine adenocarcinoma. World J Surg Oncol; 2007;5:100

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perianal eccrine adenocarcinoma.
  • BACKGROUND: Eccrine carcinoma is a quite rare malignant tumor that typically arises from a normal sweat gland and that features a rather high recurrence rate subsequent to simple excision.
  • CASE PRESENTATION: Herein, we report on an unusual case of perianal eccrine carcinoma, initially presenting as a perianal abscess.
  • CONCLUSION: Even though eccrine carcinomas would appear to be rare, when dealing with recurrent skin tumors or recurrent perianal fistulas, the possibility of eccrine carcinoma should be considered by consulting clinicians.

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  • (PMID = 17822569.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2034570
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58. Amel T, Olfa G, Faten H, Makrem H, Slim BA, Moncef M: Metastatic hidradenocarcinoma: Surgery and chemotherapy. N Am J Med Sci; 2009 Dec;1(7):372-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic hidradenocarcinoma: Surgery and chemotherapy.
  • CONTEXT: Hidradenocarcinoma is a rare carcinoma of high malignant potential.
  • CASE REPORT: We report a case of 52-year-old woman who presented with an invasive hidradenocarcinoma of the finger, treated with surgical excision.
  • CONCLUSION: Hidradenocarcinoma is an aggressive tumor.

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  • [Cites] Cancer. 1990 Apr 15;65(8):1737-40 [2156600.001]
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  • (PMID = 22666726.001).
  • [ISSN] 2250-1541
  • [Journal-full-title] North American journal of medical sciences
  • [ISO-abbreviation] N Am J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3364684
  • [Keywords] NOTNLM ; Hidradenocarcinoma / chemotherapy. / metastases
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59. Murray K, Patel R, Payne-Blackmon SP: Primary cutaneous mucinous adenocarcinoma of the face: a case report in a 63 year-old. Laryngoscope; 2010;120 Suppl 4:S133

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous mucinous adenocarcinoma of the face: a case report in a 63 year-old.
  • Primary cutaneous mucinous adenocarcinoma is a rare sweat gland malignancy that most commonly occurs in the head and neck region.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Facial Neoplasms / diagnosis

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  • (PMID = 21225731.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Pucevich B, Catinchi-Jaime S, Ho J, Jukic DM: Invasive primary ductal apocrine adenocarcinoma of axilla: a case report with immunohistochemical profiling and a review of literature. Dermatol Online J; 2008;14(6):5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Invasive primary ductal apocrine adenocarcinoma of axilla: a case report with immunohistochemical profiling and a review of literature.
  • Primary cutaneous ductal apocrine adenocarcinoma (PCDAA) is a rare malignant cutaneous neoplasm usually arising in areas of high apocrine gland density.
  • There have been a total of 40 cases of primary apocrine adenocarcinoma reported in the literature; many are indolent and slowly- developing, but some are rapidly progressive.
  • Primary cutaneous ductal apocrine adenocarcinoma has distinctive histologic and immunohistochemical characteristics and the treatment of choice for PCDAA is wide local excision with clear margins.
  • We present a case of a 92-year-old female with a 1-year history of a subcutaneous tumor of the right axilla, histologically consistent with a diagnosis of PCDAA arising in an accessory nipple.
  • To our knowledge this is the first reported case of apocrine adenocarcinoma to develop in an accessory nipple.
  • [MeSH-major] Adenocarcinoma / pathology. Apocrine Glands. Axilla. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neoplasm Invasiveness

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  • (PMID = 18713586.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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61. Abbott JJ, Ahmed I: Adenocarcinoma of mammary-like glands of the vulva: Report of a case and review of the literature. Am J Dermatopathol; 2006 Apr;28(2):127-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of mammary-like glands of the vulva: Report of a case and review of the literature.
  • Excisional biopsy and Mohs micrographic surgery demonstrated an infiltrating adenocarcinoma of the mammary-like glands involving the dermis and subcutis.
  • On review of all 20 cases, the mean age at diagnosis was 59.6 years, the labia majora were involved in 13 cases (65%), and the mean lesional size was 2.5 cm.
  • The tumor's histologic patterns varied greatly, although the histomorphologic similarity among this neoplasm, sweat gland carcinomas, and invasive extramammary Paget disease suggested a morphologic spectrum among these tumors.
  • Criteria for establishing the diagnosis of adenocarcinoma of mammary-like glands include identifying transition zones between normal mammary-like glands and adenocarcinomatous areas.
  • [MeSH-major] Adenocarcinoma / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Dermis / pathology. Epithelium / pathology. Female. Follow-Up Studies. Humans. Mammary Glands, Human / pathology. Middle Aged. Mohs Surgery

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  • (PMID = 16625074.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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62. Francisco JS, Alfaro SE, Oliveira DC, Tonon S, Dias EP: Apocrine carcinoma in the parotid gland and in the submandibular region. Braz J Otorhinolaryngol; 2005 Mar-Apr;71(2):224-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine carcinoma in the parotid gland and in the submandibular region.
  • The objectives of this paper are to report a case of apocrine carcinoma and the discussion of aspects related to its diagnosis, treatment, and prognosis.
  • Carcinomas with apocrine differentiation not related to extramammary Paget's disease, ductal breast carcinoma, Moll's glands adenocarcinoma and ceruminous glands carcinoma are very uncommon tumors.
  • We report a case of a 51-year-old black woman who developed apocrine carcinoma lesions in the head and neck region.
  • Two lesions involved her left parotid gland (first tumor and local recurrence), and other involved her submandibular skin.
  • Based on cutaneous apocrine carcinoma compatibility of the microscopic aspects, we concluded that the tumor in the submandibular skin was probably the primary neoplasm.
  • [MeSH-major] Apocrine Glands. Carcinoma / pathology. Mouth Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16446921.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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63. Zhang Q, Wojno TH, Fitch SD, Grossniklaus HE: Mucinous eccrine adenocarcinoma of the eyelid: report of 6 cases. Can J Ophthalmol; 2010 Feb;45(1):76-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucinous eccrine adenocarcinoma of the eyelid: report of 6 cases.
  • OBJECTIVE: To report on patients with mucinous eccrine adenocarcinoma of the eyelid.
  • The pathologic diagnoses were mucinous eccrine adenocarcinomas.
  • CONCLUSIONS: Mucinous eccrine adenocarcinoma is an uncommon adnexal tumour that can involve the eyelid, has low metastasis and mortality, but can be invasive or locally recur.
  • Mohs micrographic surgery is a recommended treatment of mucinous eccrine adenocarcinoma of the eyelid.

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  • (PMID = 20130716.001).
  • [ISSN] 1715-3360
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / P30 EY006360; None / None / / P30 EY006360-25; United States / NEI NIH HHS / EY / P30 EY006360-25
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS239412; NLM/ PMC2992875
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64. Shah SS, Adelson M, Mazur MT: Adenocarcinoma in situ arising in vulvar papillary hidradenoma: report of 2 cases. Int J Gynecol Pathol; 2008 Jul;27(3):453-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma in situ arising in vulvar papillary hidradenoma: report of 2 cases.
  • Adenocarcinoma in situ rarely occurs in vulvar papillary hidradenoma.
  • We encountered 2 cases of adenocarcinoma in situ arising in a papillary hidradenoma of the vulva.
  • On microscopic examination, the tumors showed focal features of benign hidradenoma at the periphery with transitions into areas of increasing cytologic atypia that fulfilled criteria for adenocarcinoma in situ similar to that seen in the breast.
  • The fact that these tumors displayed morphologic and immunohistochemical features that resembled ductal carcinoma in situ of the breast demonstrates the close homology between papillary hidradenoma and breast epithelium.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Carcinoma in Situ / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 18580327.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Rammeh-Rommani S, Ben Ghanem A, Laatiri N, Jenhani F, Fezaa B, Kammoun MR, Baltagi Ben Jilani S, Zermani R: [Study of the ploidy and cellular cycle of hidradenomas and hidradenocarcinomas: a series of 13 cases]. Tunis Med; 2007 May;85(5):409-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Study of the ploidy and cellular cycle of hidradenomas and hidradenocarcinomas: a series of 13 cases].
  • [Transliterated title] Etude de la ploïdie et du cycle cellulaire des hidradenomes et des hidradenocarcinomes: a propos d'une série de 13 cas.
  • AIMS: To study by flow cytometry (FCM) the ploidy and the cellular cycle of nodular hidradenoma (NH) and hidradenocarcinoma (HC) and to assess the prognostic utility of this technique in such tumors.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Cell Cycle. Ploidies. Sweat Gland Neoplasms / pathology

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  • (PMID = 17657929.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Tunisia
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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66. Akinci M, Salan A, Cetin B, Aslan S: Primary mucinous eccrine adenocarcinoma of the skin in a 69-year-old man. Chirurgia (Bucur); 2010 Jan-Feb;105(1):109-11

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  • [Title] Primary mucinous eccrine adenocarcinoma of the skin in a 69-year-old man.
  • The authors report a rare case of primary mucinous eccrine adenocarcinoma of the skin initially diagnosed as metastatic adenocarcinoma and treated with local excision and adjuvant radiotherapy in another center.
  • Diagnosis in our center was primary cutaneous eccrine mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Axilla / pathology. Eccrine Glands / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 20405690.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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67. Kim Y, Scolyer RA, Chia EM, Steven D, Ghabrial R: Eccrine porocarcinoma of the upper eyelid. Australas J Dermatol; 2005 Nov;46(4):278-81
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  • [Title] Eccrine porocarcinoma of the upper eyelid.
  • Incisional biopsy of the lesion revealed a malignant tumour that was thought to possibly represent a sebaceous carcinoma.
  • However, a subsequent wide surgical excision showed that the tumour was an eccrine porocarcinoma, a rare sweat gland adenocarcinoma arising from the acrosyringium.
  • [MeSH-major] Carcinoma / pathology. Eccrine Glands / pathology. Eyelid Diseases / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16197432.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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68. MacNeill KN, Riddell RH, Ghazarian D: Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. J Clin Pathol; 2005 Feb;58(2):217-9
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  • [Title] Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature.
  • This report describes the case of an invasive apocrine adenocarcinoma arising in a benign adenoma in the perianal region of a 45 year old woman.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Anus Neoplasms / pathology. Apocrine Glands / pathology. Sweat Gland Neoplasms / pathology

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  • [Cites] J Clin Pathol. 1999 Nov;52(11):829-32 [10690173.001]
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  • (PMID = 15677547.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 12
  • [Other-IDs] NLM/ PMC1770559
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69. Mecca P, Busam K: Primary male neuroendocrine adenocarcinoma involving the nipple simulating Merkel cell carcinoma - a diagnostic pitfall. J Cutan Pathol; 2008 Feb;35(2):207-11
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  • [Title] Primary male neuroendocrine adenocarcinoma involving the nipple simulating Merkel cell carcinoma - a diagnostic pitfall.
  • Likewise, true neuroendocrine carcinoma of the breast, defined as > 50% of tumor cells staining for either chromogranin or synaptophysin, is not a common entity, usually occurring in older women.
  • The histology consisted of nests, trabeculae and sheets of basaloid cells with rare abortive gland formation and a pushing edge.
  • The case was originally misdiagnosed as a Merkel cell carcinoma, based largely on histologic morphology.
  • Additionally, a substantial portion of cells stained for Gross Cystic Disease Fluid Protein-15 (GCDFP-15), confirming some overlap with sweat duct differentiation.
  • To the best of our knowledge, although reported in the male breast, no case of primary nipple neuroendocrine carcinoma in a male patient has been reported in the literature.
  • The gender of the patient and association with the skin of the chest wall probably contributed to the original misdiagnosis of Merkel cell carcinoma in this patient.
  • [MeSH-major] Breast Neoplasms, Male / pathology. Carcinoma, Merkel Cell / pathology. Carcinoma, Neuroendocrine / pathology. Diagnostic Errors. Nipples / pathology

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  • (PMID = 18190447.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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70. Breiting LB, Christensen L, Dahlstrøm K, Winther JF, Breiting VB, Kalialis LV: [Primary mucinous carcinoma of the skin--a literature review]. Ugeskr Laeger; 2008 Oct 20;170(43):3399-402
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  • [Title] [Primary mucinous carcinoma of the skin--a literature review].
  • [Transliterated title] Primaert mucinøst karcinom i huden--en oversigt over litteraturen.
  • Primary mucinous carcinoma of the skin (PKMK) is a rare malignant tumour of the sweat glands.
  • It is often misdiagnosed as it has an uncharacteristic gross appearance - and may microscopically resemble a cutaneous metastasis from a mucinous carcinoma of the breast, gastrointestinal tract, lungs, ovaries or prostate.
  • [MeSH-major] Adenocarcinoma, Mucinous. Skin Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Recurrence, Local. Prognosis. Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / pathology. Sweat Gland Neoplasms / surgery

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  • (PMID = 18976593.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 40
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71. Samaila MO: Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med; 2008 Mar;7(1):6-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Only two cases had a clinical diagnosis of adnexal tumor.
  • Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas.
  • Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma.
  • Forty-six lesions (88.5%) were benign and six (11.5%) malignant.
  • The commonest variants are those of eccrine sweat gland origin.
  • Malignant adnexal tumors are uncommon in our setting.
  • [MeSH-major] Carcinoma, Skin Appendage / classification. Neoplasms, Adnexal and Skin Appendage / classification
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / pathology. Adenoma, Sweat Gland / epidemiology. Adenoma, Sweat Gland / pathology. Adolescent. Adult. Aged. Child. Child, Preschool. Female. Hair Follicle / pathology. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / pathology. Humans. Infant, Newborn. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / pathology. Sweat Gland Neoplasms / epidemiology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18702242.001).
  • [ISSN] 1596-3519
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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72. Obaidat NA, Awamleh AA, Ghazarian DM: Adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma of the peri-anal region. Eur J Dermatol; 2006 Sep-Oct;16(5):576-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma of the peri-anal region.
  • Histologically, the excised lesion showed features of tubulopapillary apocrine hidradenoma, with an area showing features of carcinoma in situ.
  • The lesion also had papillary and cribriform growth patterns, reminiscent of breast lesions.
  • To the best of our knowledge, this is the first description of a peri-anal adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17101482.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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73. Tuncel A, Sezgin T, Uzum N, Ataoglu O, Atan A: Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report. Can J Urol; 2009 Oct;16(5):4860-2
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  • [Title] Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report.
  • In histopathological examination, apocrine adenocarcinoma was diagnosed.
  • [MeSH-major] Adenocarcinoma / secondary. Apocrine Glands. Bone Neoplasms / secondary. Liver Neoplasms / secondary. Scrotum. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Middle Aged. Tomography, X-Ray Computed. Urologic Surgical Procedures, Male / methods

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  • (PMID = 19796468.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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74. Roy S, Shafi NQ, Rose MG: Locally recurrent and metastatic apocrine-gland carcinoma in an elderly man. Nat Clin Pract Oncol; 2007 Jan;4(1):56-9

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  • [Title] Locally recurrent and metastatic apocrine-gland carcinoma in an elderly man.
  • DIAGNOSIS: Carcinoma of the axillary apocrine gland.
  • [MeSH-major] Adenocarcinoma / pathology. Apocrine Glands. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Axilla. Diagnosis, Differential. Humans. Lymphatic Diseases / diagnosis. Male. Neoplasm Metastasis. Neoplasm Recurrence, Local

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  • (PMID = 17183356.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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75. Nazarian RM, Kapur P, Rakheja D, Piris A, Duncan LM, Mihm MC Jr, Hoang MP: Atypical and malignant hidradenomas: a histological and immunohistochemical study. Mod Pathol; 2009 Apr;22(4):600-10
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  • [Title] Atypical and malignant hidradenomas: a histological and immunohistochemical study.
  • The histological features of atypical hidradenoma are worrisome for increased risk of recurrence and possible malignant potential; however, earlier studies with immunohistochemistry or patient follow-up have not been reported.
  • In addition, immunohistochemical analysis of hidradenocarcinoma exists in the literature mainly as case reports and as a single series of six cases.
  • We compare the histological features and Ki-67, phosphorylated histone H3, epidermal growth factor receptor, and Her2/neu expression profiles of 15 atypical and 15 malignant hidradenomas with those of benign hidradenoma and metastasizing adnexal carcinomas.
  • Infiltrative growth pattern, deep extension, necrosis, nuclear pleomorphism, and > or =4 mitoses per 10 high-power fields are specific features of hidradenocarcinomas.
  • Significant difference in mean Ki-67% was observed between benign and malignant hidradenomas (P<0.001), benign and metastasizing adnexal carcinomas (0.002), atypical and malignant hidradenomas (P<0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (0.002).
  • Significant difference in mean phosphorylated histone H3% was observed between benign and malignant hidradenomas (P<0.001), benign and metastasizing adnexal carcinomas (0.003), atypical and malignant hidradenomas (P<0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (P<0.001).
  • Mean epidermal growth factor receptor total score was significantly different in benign and atypical hidradenoma when compared with that in metastasizing adnexal carcinoma (P=0.014 and 0.019, respectively).
  • Equivocal or 2+ Her2/neu positivity was observed in one hidradenocarcinoma and in two metastasizing adnexal carcinomas.
  • Receiver operating characteristic curve analysis for Ki-67 and phosphorylated histone H3% positivity reveals statistically significant criterion values of >11.425 and >0.7, respectively, for distinguishing malignant hidradenomas from atypical hidradenomas.
  • Despite the presence of some worrisome histological features, the significantly different immunoprofile from the malignant counterpart suggests that atypical hidradenomas are likely to recur but are unlikely to metastasize.
  • A tumor with Ki-67>11% and/or phosphorylated histone H3>0.7% would likely be a malignant rather than an atypical hidradenoma.
  • The infrequent Her2/neu overexpression in hidradenocarcinoma suggests its limited therapeutic role.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Biomarkers, Tumor / analysis. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology

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  • (PMID = 19252473.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Histones; 0 / Ki-67 Antigen; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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76. Kalialis LV, Breiting LB, Klausen S, Dahlstrøm K: [Primary mucinous carcinoma of the skin]. Ugeskr Laeger; 2008 Oct 20;170(43):3403-4
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  • [Title] [Primary mucinous carcinoma of the skin].
  • [Transliterated title] Primaert mucinøst karcinom i huden.
  • Primary mucinous carcinoma of the skin is a rare malignant tumour originating from the sweat glands.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Lymphatic Metastasis. Middle Aged. Sweat Gland Neoplasms / pathology. Sweat Gland Neoplasms / secondary. Sweat Gland Neoplasms / surgery

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  • (PMID = 18976594.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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77. Carvalho J, Fullen D, Lowe L, Su L, Ma L: The expression of CD23 in cutaneous non-lymphoid neoplasms. J Cutan Pathol; 2007 Sep;34(9):693-8
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  • In our routine practice, we observed that CD23 reacted strongly with eccrine and apocrine secretory coils.
  • METHODS: Immunohistochemical staining of CD23 was performed in a total of 131 cases of apocrine, eccrine, follicular and other cutaneous non-lymphoid tumors.
  • RESULTS: CD23 expression was detected in all benign apocrine tumors and in half of benign eccrine tumors, particularly those derived from secretory coils.
  • CD23 staining was seen in 42% (8/19) of microcystic adnexal carcinoma (MAC), while no staining was observed in tumor cells of desmoplastic trichoepithelioma, morpheaform basal cell carcinoma and syringoma.
  • In comparison, pagetoid Bowen's disease, melanoma in situ and sebaceous carcinoma exhibited negative staining.
  • In addition, CD23 reacted diffusely with cutaneous mucinous eccrine carcinoma in a manner similar to breast or colonic adenocarcinoma.
  • CONCLUSION: CD23 appears to be a reliable immunohistochemical marker of the eccrine/apocrine secretory coil and helpful in identifying sweat gland tumors of such origin.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Receptors, IgE / metabolism. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Apocrine Glands / metabolism. Apocrine Glands / pathology. Eccrine Glands / metabolism. Eccrine Glands / pathology. Humans

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  • (PMID = 17696916.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, IgE
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78. Battistella M, Mateus C, Lassau N, Chami L, Boukoucha M, Duvillard P, Cribier B, Robert C: Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. J Eur Acad Dermatol Venereol; 2010 Feb;24(2):199-203
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  • [Title] Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma.
  • OBSERVATIONS: The first patient had metastatic clear cell hidradenocarcinoma and was stabilized over 8 months with sunitinib, before she relapsed.
  • The second patient had a metastatic malignant hair follicle tumour (trichoblastic carcinoma) and achieved a partial remission with sunitinib, and disease stabilized after 10 months.
  • [MeSH-major] Acrospiroma / drug therapy. Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Indoles / therapeutic use. Neoplasm Metastasis. Pyrroles / therapeutic use. Skin Neoplasms / drug therapy

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  • (PMID = 19522717.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Indoles; 0 / Pyrroles; 0 / sunitinib
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79. Mellanby RJ, Craig R, Evans H, Herrtage ME: Plasma concentrations of parathyroid hormone-related protein in dogs with potential disorders of calcium metabolism. Vet Rec; 2006 Dec 16;159(25):833-8
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  • The plasma concentrations of total calcium, ionised calcium, albumin, parathyroid hormone and parathyroid hormone-related protein (PTHrp) were measured in 25 dogs with lymphoma, nine dogs with primary hyperparathyroidism and seven dogs with adenocarcinoma of the apocrine gland of the anal sac.
  • The concentration of PTHrp was high in 12 of the 14 dogs that were hypercalcaemic because of an underlying malignancy but was within the reference range in all the control dogs, in the 17 normocalcaemic dogs with lymphoma and in the seven dogs which were hypercalcaemic because of a parathyroid adenoma.
  • [MeSH-major] Dog Diseases / diagnosis. Hypercalcemia / veterinary. Parathyroid Hormone-Related Protein / blood
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / veterinary. Anal Sacs. Animals. Case-Control Studies. Dogs. Hyperparathyroidism / diagnosis. Hyperparathyroidism / veterinary. Lymphoma / diagnosis. Lymphoma / veterinary. Predictive Value of Tests. Sensitivity and Specificity. Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / veterinary

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  • (PMID = 17172477.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein
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80. Sheth RN, Placantonakis DG, Gutin PH: Intracranial and spinal metastases from eccrine mucinous carcinoma: case report. Neurosurgery; 2010 Sep;67(3):E861-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial and spinal metastases from eccrine mucinous carcinoma: case report.
  • BACKGROUND AND IMPORTANCE: Mucinous eccrine carcinoma (MEC) is a rare but distinct type of sweat gland tumor.
  • Pathology confirmed the diagnosis of MEC.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Brain Neoplasms / secondary. Neoplasm Metastasis / pathology. Spinal Neoplasms / secondary. Sweat Gland Neoplasms / pathology

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  • (PMID = 20657314.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Wahl CE, Todd DH, Binder SW, Cassarino DS: Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. J Cutan Pathol; 2009 May;36(5):582-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia.
  • An excisional biopsy of the lesion showed a fairly well-circumscribed but focally invasive tumor consisting of areas of typical-appearing clear cell hidradenoma as well as areas with mucinous goblet-type cells and cells with eosinophilic cytoplasm and decapitation-type secretion.
  • The patient was diagnosed with hidradenocarcinoma with mucinous differentiation.
  • Associated Paget's disease has only rarely been reported, and mucinous metaplasia is a previously unreported feature in hidradenocarcinoma.
  • [MeSH-major] Apocrine Glands / pathology. Carcinoma, Skin Appendage / pathology. Mucins / metabolism. Paget Disease, Extramammary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19476529.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-7; 0 / Mucin-1; 0 / Mucins
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82. Schadt CR, Boyd AS: Eccrine syringofibroadenoma with co-existent squamous cell carcinoma. J Cutan Pathol; 2007 Dec;34 Suppl 1:71-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine syringofibroadenoma with co-existent squamous cell carcinoma.
  • Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal tumor arising most often on the extremities of elderly individuals.
  • The cords contain scattered ductal structures lined with cuboidal cells resembling eccrine ducts.
  • The co-existence of ESFA with squamous cell carcinoma has been described, eliciting the term eccrine syringofibroadenoma.
  • The differential diagnosis includes poroma, porocarcinoma, fibroepithelioma of Pinkus and clear cell acanthoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Squamous Cell / pathology. Eccrine Glands / pathology. Fibroadenoma / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Acanthoma / diagnosis. Acrospiroma / diagnosis. Adenocarcinoma / diagnosis. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasms, Fibroepithelial / diagnosis

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  • (PMID = 17997744.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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83. Kaya H, Bozkurt SU, Erbarut I, Djamgoz MB: Apocrine carcinomas of the breast in Turkish women: hormone receptors, c-erbB-2 and p53 immunoexpression. Pathol Res Pract; 2008;204(6):367-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aims of this study were twofold: (i) to determine the occurrence frequency of apocrine carcinoma of the breast (ApBCa) in Turkish breast cancer (BCa) patients; and (ii) to evaluate the expression of estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), gross cystic disease protein-15 (GCDFP-15), c-erbB-2, and p53 in these cases.
  • The results of ApBCa were compared with those of invasive ductal carcinoma not otherwise specified type (IDC-NOS) cases of similar grade.
  • [MeSH-major] Adenocarcinoma / metabolism. Breast Neoplasms / metabolism. Receptor, ErbB-2 / metabolism. Receptors, Steroid / metabolism. Sweat Gland Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adult. Aged. Apocrine Glands / metabolism. Apocrine Glands / pathology. Biomarkers, Tumor / metabolism. Carcinoma, Ductal, Breast / metabolism. Carcinoma, Ductal, Breast / pathology. Carrier Proteins / metabolism. Female. Glycoproteins / metabolism. Humans. Immunoenzyme Techniques. Middle Aged

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  • (PMID = 18342452.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Glycoproteins; 0 / PIP protein, human; 0 / Receptors, Steroid; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, ErbB-2
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84. Jih MH, Friedman PM, Kimyai-Asadi A, Goldberg LH: A rare case of fatal primary cutaneous mucinous carcinoma of the scalp with multiple in-transit and pulmonary metastases. J Am Acad Dermatol; 2005 May;52(5 Suppl 1):S76-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of fatal primary cutaneous mucinous carcinoma of the scalp with multiple in-transit and pulmonary metastases.
  • BACKGROUND: Primary cutaneous mucinous carcinoma is a rare neoplasm derived from the sweat glands.
  • CASE REPORT: We report a patient presenting with rapidly progressive cutaneous mucinous carcinoma on the right parietal scalp.
  • The tumor was treated with Mohs micrographic surgery with clear margins.
  • However, within two months, the patient developed new lesions on the scalp both adjacent to and separate from the original previously excised area, as well as metastasis to the right parotid gland.
  • The patient received adjuvant radiation therapy both to the scalp lesions and to the parotid gland with apparent control of locoregional disease.
  • CONCLUSION: Primary mucinous carcinoma arising in the skin is rare and usually follows an indolent course.
  • We report the rare occurrence of a mucinous carcinoma of the scalp that developed multiple cutaneous tumors caused by in-transit metastases, as well as parotid gland metastases and eventual fatal pulmonary metastases.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Lung Neoplasms / secondary. Scalp / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Fatal Outcome. Humans. Male. Parotid Gland / pathology. Tomography, X-Ray Computed

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  • [CommentIn] J Am Acad Dermatol. 2006 Oct;55(4):726-7 [17010765.001]
  • (PMID = 15858515.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Sierra Montenegro E, Sierra Luzuriaga G, Leone Stay G, Salazar Menéndez V, Quiñonez Auria C: Perianal nodular hidradenocarcinoma. Case report. Cir Cir; 2010 Mar-Apr;78(2):173-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perianal nodular hidradenocarcinoma. Case report.
  • BACKGROUND: Eccrine glands (sweat glands) appear in all sites of the skin and are more abundant in hands and feet.
  • Nodular hidradenocarcinoma (NH) is a rare malignant and aggressive tumor of the eccrine glands.
  • The objective of this study is to report a case of perianal hidradenocarcinoma.
  • Pathology report revealed perianal hidradenoma.
  • Definitive pathology report was malignant eccrine acrospiroma.
  • [MeSH-major] Eccrine Glands. Sweat Gland Neoplasms

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  • (PMID = 20478121.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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86. Karolina Z, Arkadiusz P, Jolanta OH, Bozena RD: Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. Klin Oczna; 2010;112(1-3):49-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy.
  • PURPOSE: Presentation of a case of very rare malignant tumor of eccrine sweat glands in the eyelid.
  • CONCLUSIONS: Sweat gland carcinomas are rare malignant tumors of the skin adnexa.
  • Diagnosis of these carcinomas is difficult due to their infrequency.
  • [MeSH-major] Eccrine Glands. Eyelid Neoplasms / pathology. Hidrocystoma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 20572504.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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87. Warycha M, Kamino H, Mobini N, Hale EK: Primary mucinous carcinoma with direct histopathologic evidence of lymphatic invasion. J Drugs Dermatol; 2006 Jul-Aug;5(7):655-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mucinous carcinoma with direct histopathologic evidence of lymphatic invasion.
  • BACKGROUND: Primary mucinous carcinoma of the skin is a rare sweat gland neoplasm which occurs most commonly in the periorbital region.
  • The standard treatment of primary mucinous carcinoma is wide local excision.
  • OBJECTIVE: We present a case of primary mucinous carcinoma arising in the scalp, which was treated with wide local excision.
  • CONCLUSION: Primary mucinous carcinoma has a high propensity for locoregional metastases and recurrence.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Lymphatic Metastasis. Skin Neoplasms / pathology

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  • (PMID = 16865872.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Amonkar GP, Amonkar PP, Rege JD: Bilateral axillary apocrine nevi--a case report. Indian J Pathol Microbiol; 2005 Jan;48(1):22-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / pathology. Apocrine Glands / pathology. Axilla / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16758779.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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89. Schulman FY, Lipscomb TP, Atkin TJ: Canine cutaneous clear cell adnexal carcinoma: histopathology, immunohistochemistry, and biologic behavior of 26 cases. J Vet Diagn Invest; 2005 Sep;17(5):403-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Canine cutaneous clear cell adnexal carcinoma: histopathology, immunohistochemistry, and biologic behavior of 26 cases.
  • Characteristic histopathologic features included location in the subcutis or dermis (or both); lobular, nodular, and nest-like architecture; and a component of epithelioid cells with clear cytoplasm.
  • The findings are consistent with a poorly differentiated, low-grade, adnexal carcinoma of the skin.
  • Similar canine cutaneous neoplasms have been reported as "clear-cell hidradenocarcinoma" and "follicular stem cell carcinoma."
  • The authors propose the designation "cutaneous clear cell adnexal carcinoma. "
  • [MeSH-major] Adenocarcinoma, Clear Cell / veterinary. Carcinoma, Skin Appendage / veterinary. Dog Diseases / pathology. Skin Neoplasms / veterinary

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  • (PMID = 16312230.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Alsaad KO, Obaidat N, Dube V, Chapman W, Ghazarian D: Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. Pathol Res Pract; 2009;205(2):131-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation.
  • They are classified into extramammary Paget's disease, sweat gland carcinomas, and "breast-like" adenocarcinomas of the vulva.
  • Rare cases of adenocarcinoma with apocrine features have been reported, and whether these neoplasms originate from the "native apocrine" sweat glands or from "anogenital mammary-like" glands are still debatable.
  • The presence of normal mammary-like glands in the vicinity of the tumor, the transitional malignant morphological features from normal mammary-like glands and the tumor, the breast-like histological features of the tumor, and the expression of estrogen and progesterone receptors generally suggest an origin from anogenital mammary-like glands.
  • Absence of these features points toward native apocrine sweat glands as the source of these neoplasms.
  • In this report, we present a patient who was initially diagnosed with Paget's disease of the right vulva, which was treated by hemi-vulvectomy, and who later presented with primary vulvar apocrine adenocarcinoma with metastasis to the inguinal lymph nodes and intranodal mucinous/colloidal differentiation: a feature, to the best of our knowledge, not reported before.
  • We also reviewed the histogenesis of the vulvar adenocarcinomas, with emphasis on the morphological features that separate the tumors arising from the anogenital mammary-like glands in the vulva from those arising from the native vulvar sweat glands.
  • [MeSH-major] Adenocarcinoma / pathology. Apocrine Glands / pathology. Lymphatic Metastasis / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Aged, 80 and over. Arthritis, Rheumatoid / complications. Cell Differentiation. Female. Gynecologic Surgical Procedures. Humans. Hypertension / complications. Osteoporosis / complications. Paget Disease, Extramammary / complications

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  • (PMID = 18842349.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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91. McLean SR, Shousha S, Francis N, Lim A, Eccles S, Nathan M, Brock CS, Palmieri C: Metastatic ductal eccrine adenocarcinoma masquerading as an invasive ductal carcinoma of the male breast. J Cutan Pathol; 2007 Dec;34(12):934-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic ductal eccrine adenocarcinoma masquerading as an invasive ductal carcinoma of the male breast.
  • We report the case of a 38-year-old man with metastatic ductal eccrine adenocarcinoma (DEA) of the left breast responding to 5-flourouracil, epirubicin and cyclophosphamide (FEC) chemotherapy.
  • A punch biopsy of the breast lesion resulted in a diagnosis of metastatic invasive ductal carcinoma (IDC) of the breast.
  • This showed tumor cells that were polygonal with darkly stained pleomorphic nuclei and abundant eosinophilic cytoplasm and were also localized to areas of fibrotic stroma containing eccrine glands and ducts but did not appear to involve mammary tissue.
  • Both the morphological and the immunohistochemical characteristics of the tumor were consistent with a revised diagnosis of DEA rather than IDC.
  • [MeSH-major] Adenocarcinoma / pathology. Breast Neoplasms, Male / pathology. Carcinoma, Ductal, Breast / pathology. Eccrine Glands / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18001417.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Bone Density Conservation Agents; 0 / Diphosphonates; 094ZI81Y45 / Tamoxifen; 114084-78-5 / ibandronic acid; 3Z8479ZZ5X / Epirubicin; 8N3DW7272P / Cyclophosphamide; U3P01618RT / Fluorouracil
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92. Ogino T, Noura S, Ohue M, Matsumura M, Ishiguro S, Kishi K, Takachi K, Eguchi H, Yamada T, Miyashiro I, Yano M, Ohigashi H, Sasaki Y, Ishikawa O, Imaoka S: [A case of apocrine adenocarcinoma suspected as an axillary lymph node metastasis from cecal cancer]. Gan To Kagaku Ryoho; 2006 Nov;33(12):1968-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of apocrine adenocarcinoma suspected as an axillary lymph node metastasis from cecal cancer].
  • Biopsy of the tumor showed the features of metastatic adenocarcinoma.
  • Axillary tumor was diagnosed not as metastasis of axillary lymph nodes from cecal cancer but apocrine adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Apocrine Glands. Cecal Neoplasms / pathology. Lymphatic Metastasis
  • [MeSH-minor] Aged. Axilla. Colonoscopy. Diagnosis, Differential. Humans. Male. Neoplasms, Multiple Primary / diagnosis. Sweat Gland Neoplasms / secondary

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  • (PMID = 17212162.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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93. Kourda N, Zaraa I, Abid L, Zitouni K, Adouani A, Baltagi-Ben Jilani S, Zermani R: [Primary mucinous carcinoma of the skin. A case report]. Ann Pathol; 2006 Jun;26(3):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary mucinous carcinoma of the skin. A case report].
  • Primary mucinous carcinoma of the skin is a rare sweat-gland neoplasm with a high recurrence rate.
  • We report a new case of a primary recurrent mucinous carcinoma of the face in a 59-year-old man.
  • Histologically, mucinous carcinoma of the skin can be mistaken for a metastasis from extracutaneous sites, particularly the breast or the gastrointestinal tract.
  • Mucinous carcinoma of the skin has a relatively good prognosis with rare distant metastases, but high recurrence rate.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Division. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17127853.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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94. Reid-Nicholson M, Iyengar P, Friedlander MA, Lin O: Fine needle aspiration biopsy of primary mucinous carcinoma of the skin: a case report. Acta Cytol; 2006 May-Jun;50(3):317-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration biopsy of primary mucinous carcinoma of the skin: a case report.
  • BACKGROUND: Primary mucinous carcinoma of the skin is a rare neoplasm of sweat gland origin.
  • FNAB of the nodules confirmed a recurrence of mucinous carcinoma.
  • Clinical examination and extensive radiographic studies did not reveal primary disease elsewhere, thus supporting a diagnosis of primary mucinous carcinoma of the skin.
  • The patient declined adjuvant therapy and was disease free 6 months after the initial diagnosis.
  • CONCLUSION: Cutaneous mucinous carcinoma is a tumor characterized by bland histocytologic features and abundant extracellular pools of mucin.
  • Numerous benign and malignant mucin-producing primary and secondary mimics exist, and immunohistochemistry offers limited benefits in differentiating them.
  • Cytologic diagnosis of primary mucinous carcinoma of the skin is possible; however, correlation of clinical, radiologic and pathologic features is necessary to arrive at an accurate diagnosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Head and Neck Neoplasms / pathology. Scalp. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 16780028.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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95. Verret DJ, Kabbani W, DeFatta RJ: Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. Head Neck; 2007 Feb;29(2):193-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation.
  • BACKGROUND: Nodular hidradenocarcinoma (NHAC), an eccrine carcinoma, has been reported in the dermatology and pathology literature, but few references have been made in the otolaryngology literature even though the head and neck is a common site of occurrence.
  • CONCLUSION: NHAC is an aggressive malignant tumor that is often misdiagnosed preoperatively and that must be treated with aggressive multimodality therapy for increased survival.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Parotid Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17103407.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Akhtar I, Ispas CL, Flowers R, Siddiqi A, Young L, Donnellan KA, Heard K, Baliga M: Ductopapillary apocrine carcinoma of the eyelid metastatic to the parotid gland: report of a case diagnosed by fine-needle aspiration biopsy. Diagn Cytopathol; 2009 Feb;37(2):91-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ductopapillary apocrine carcinoma of the eyelid metastatic to the parotid gland: report of a case diagnosed by fine-needle aspiration biopsy.
  • Ductopapillary apocrine carcinoma (DPAC) of the eyelid is a rare malignant neoplasm in the periocular region.
  • The relative rarity of this tumor is a diagnostic challenge to the cytopathologist, especially when present as a metastatic lesion to an intraparotid lymph node, where the differential diagnosis includes primary parotid neoplasms, as well as various other metastatic malignancies.
  • We report a case of a 65-year-old African-American male with a history of ductopapillary apocrine adenocarcinoma of the eyelid, diagnosed 6 weeks ago now presenting with a recurrence in the same area.
  • FNAB of the parotid mass showed a well-differentiated papillary adenocarcinoma with a cystic component, similar to a previously excised ductopapillary apocrine adenocarcinoma of the eyelid.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Eyelid Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Parotid Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 19021198.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Glycoproteins; 0 / PIP protein, human
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97. Moura LR, Ayres B, Feijóo L, Romano S, Odashiro AN, Burnier MN Jr: Presumed eccrine carcinoma metastatic to the choroid. Clin Exp Ophthalmol; 2006 Sep-Oct;34(7):699-700
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Presumed eccrine carcinoma metastatic to the choroid.
  • The purpose of this article is to describe a patient with presumed choroidal metastasis from an eccrine adenocarcinoma of the scalp.
  • Her past medical history was significant for eccrine carcinoma of the scalp.
  • This is the first report of choroidal metastases from an eccrine carcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Choroid Neoplasms / secondary. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
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  • (PMID = 16970766.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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98. Somasundaram SK, Balasubramanian RK, Aref F, Karim S, Vashisht R: A rare and unusual case of bilateral, axillary, metachronous apocrine carcinoma. Int Surg; 2007 Nov-Dec;92(6):335-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare and unusual case of bilateral, axillary, metachronous apocrine carcinoma.
  • Apocrine carcinoma is a rare sweat gland neoplasm with very few cases reported in the published literature.
  • We report a case of primary axillary apocrine carcinoma with later recurrences in both axillae.
  • A 55-year-old man was clinically diagnosed with hydradenitis suppurativa in the right axilla, and after excision of lesion, histology showed metastatic adenocarcinoma of probable breast origin.
  • [MeSH-major] Adenocarcinoma / secondary. Apocrine Glands / pathology. Breast Neoplasms, Male / pathology. Neoplasms, Second Primary. Sweat Gland Neoplasms / secondary

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  • (PMID = 18402127.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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99. Miyamoto T, Adachi K, Fujishima M: Axillary apocrine carcinoma with Paget's disease and apocrine naevus. Clin Exp Dermatol; 2009 Jul;34(5):e110-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Axillary apocrine carcinoma with Paget's disease and apocrine naevus.
  • Apocrine carcinoma is a rare malignant sweat-gland neoplasm with apocrine differentiation.
  • There have been some reported cases of apocrine carcinoma with apocrine naevus.
  • The resected specimen showed apocrine adenocarcinoma with extramammary Paget's disease and apocrine naevus.
  • [MeSH-major] Adenocarcinoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Nevus / diagnosis. Paget Disease, Extramammary / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Apocrine Glands. Axilla. Humans. Male. Positron-Emission Tomography. Precancerous Conditions / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 19438526.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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100. Nash JW, Barrett TL, Kies M, Ross MI, Sneige N, Diwan AH, Lazar AJ: Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. J Cutan Pathol; 2007 Jan;34(1):49-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications.
  • Histologically, a nodular dermal proliferation composed of poorly differentiated epithelioid cells in nests and focally forming ducts with pseudopapillary architecture comprised the primary tumor.
  • Features of a clear cell hidradenoma were noted focally.
  • We believe this to be the first demonstration of Her-2/neu amplification in a malignant skin adnexal tumor.
  • In analogy to breast carcinoma, these findings suggest the applicability of trastuzumab for patients with metastatic adnexal carcinomas demonstrating Her-2/neu amplification.
  • [MeSH-major] Adenoma, Sweat Gland / genetics. Gene Amplification. Genes, erbB-2. In Situ Hybridization, Fluorescence. Lymphatic Metastasis / genetics. Sweat Gland Neoplasms / pathology






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