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1. Francisco JS, Alfaro SE, Oliveira DC, Tonon S, Dias EP: Apocrine carcinoma in the parotid gland and in the submandibular region. Braz J Otorhinolaryngol; 2005 Mar-Apr;71(2):224-7
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  • [Title] Apocrine carcinoma in the parotid gland and in the submandibular region.
  • Carcinomas with apocrine differentiation not related to extramammary Paget's disease, ductal breast carcinoma, Moll's glands adenocarcinoma and ceruminous glands carcinoma are very uncommon tumors.
  • Two lesions involved her left parotid gland (first tumor and local recurrence), and other involved her submandibular skin.
  • Based on cutaneous apocrine carcinoma compatibility of the microscopic aspects, we concluded that the tumor in the submandibular skin was probably the primary neoplasm.
  • [MeSH-major] Apocrine Glands. Carcinoma / pathology. Mouth Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16446921.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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2. Mäkitie AA, Pintor Dos Reis P, Arora S, Macmillan C, Warner GC, Sukhai M, Dardick I, Perez-Ordonez B, Wells R, Brown D, Gilbert R, Freeman J, Gullane P, Irish J, Kamel-Reid S: Molecular characterization of salivary gland malignancy using the Smgb-Tag transgenic mouse model. Lab Invest; 2005 Aug;85(8):947-61
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  • [Title] Molecular characterization of salivary gland malignancy using the Smgb-Tag transgenic mouse model.
  • The molecular mechanisms underlying salivary gland tumorigenesis remain unclear.
  • In order to identify genetic changes that occur during the development of invasive adenocarcinoma from normal salivary gland, we used the Smgb-Tag transgenic mouse model.
  • This transgene induces the progressive development of dysplasia to invasive adenocarcinoma in the submandibular salivary gland.
  • Gene expression patterns from 20 submandibular glands (two normal, nine dysplasia and nine adenocarcinoma samples) were assessed using a mouse 15 K cDNA array.
  • Further analysis identified 25 significantly overexpressed and 28 underexpressed cDNA sequences in adenocarcinoma as compared to dysplasia.
  • Differential expression of five genes (Lcn2, Ptn, Cd24a, Mapk6 and Rnps1) was validated by quantitative real-time RT-PCR in a total of 48 mouse salivary gland tissues (seven histologically normal, 13 dysplasias and 28 adenocarcinomas), including the 20 samples analyzed by cDNA arrays.
  • Immunohistochemical analysis was used to validate the expression of Ptn and Cd24a at the protein level in a subset of 16 mouse salivary glands (four normal, five dysplasia and seven adenocarcinoma samples), as well as in 23 human submandibular gland tumors (16 pleomorphic adenomas, three adenoid cystic carcinomas, one acinic cell carcinoma, one adenocarcinoma NOS, one myoepithelial and one mucoepidermoid carcinoma).
  • We thus demonstrated that the Smgb-Tag transgenic mouse model is a useful tool for the identification of genes that are deregulated in salivary gland adenocarcinomas.
  • Our data suggest that Ptn and Cd24a may be genetic markers associated with salivary gland tumorigenesis and/or progression.
  • [MeSH-major] Adenocarcinoma / genetics. Disease Models, Animal. Salivary Gland Neoplasms / genetics

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  • (PMID = 15880136.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Whitt JC, Schafer DR, Callihan MD: Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth. Head Neck Pathol; 2008 Mar;2(1):41-8
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  • [Title] Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth.
  • Salivary gland tumors usually occur as single lesions.
  • There are 31 acceptable cases of multiple malignant salivary gland neoplasms reported in the world literature.
  • Bilateral acinic cell adenocarcinoma was the most frequent combination of multiple salivary gland malignancy, accounting for 14 cases (10 synchronous and four metachronous).
  • All involved the parotid glands bilaterally with the exception of one case that involved parotid and submandibular gland.
  • Polymorphous low-grade adenocarcinoma accounted for three of the four cases of multiple malignant tumors involving minor salivary glands.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Mouth Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Palatal Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 20614341.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807610
  • [Keywords] NOTNLM ; Metachronous neoplasms / Multiple malignant salivary gland neoplasms / Salivary gland neoplasms / Salivary gland tumors / Synchronous neoplasms
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4. Roh JL, Choi SH, Lee SW, Cho KJ, Nam SY, Kim SY: Carcinomas arising in the submandibular gland: high propensity for systemic failure. J Surg Oncol; 2008 May 1;97(6):533-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinomas arising in the submandibular gland: high propensity for systemic failure.
  • BACKGROUND: Cancers of the submandibular gland are uncommon and only a few small series have reported patient survival and prognosis.
  • METHODS: We examined the treatment outcomes of 62 patients with surgically treated submandibular gland carcinomas.
  • RESULTS: Of the 62 submandibular gland carcinomas, 19 were adenoid cystic, 11 were mucoepidermoid, and 10 were salivary duct carcinomas, and 8 were carcinomas in pleomorphic adenoma.
  • CONCLUSIONS: Despite effective locoregional treatment, approximately one-third of patients with submandibular gland carcinomas may fail systemically, resulting in poor survival.
  • [MeSH-major] Neoplasm Recurrence, Local. Submandibular Gland Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Adenocarcinoma / therapy. Adolescent. Adult. Aged. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Adenoid Cystic / therapy. Carcinoma, Mucoepidermoid / mortality. Carcinoma, Mucoepidermoid / radiotherapy. Carcinoma, Mucoepidermoid / surgery. Carcinoma, Mucoepidermoid / therapy. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Survival Rate. Treatment Failure. Treatment Outcome

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18286522.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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5. Hellin-Meseguer D, Melgarejo-Moreno P, Hostalet E: Carcinoma ex pleomorphic adenoma of the submandibular gland with distant metastases. B-ENT; 2007;3(1):27-9
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  • [Title] Carcinoma ex pleomorphic adenoma of the submandibular gland with distant metastases.
  • A case of metastatic carcinoma ex pleomorphic adenoma (PA) of the submandibular gland is reported.
  • [MeSH-major] Adenocarcinoma / secondary. Adenoma, Pleomorphic / diagnosis. Bone Neoplasms / secondary. Head and Neck Neoplasms / secondary. Liver Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis. Submandibular Gland Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Needle. Cell Transformation, Neoplastic / pathology. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Neoplasm Invasiveness. Submandibular Gland / pathology. Submandibular Gland / surgery. Tomography, X-Ray Computed

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  • (PMID = 17451123.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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6. Tanahashi J, Daa T, Kashima K, Kondo Y, Yada N, Kuratomi E, Hirokawa M, Yokoyama S: Carcinosarcoma ex recurrent pleomorphic adenoma of the submandibular gland. APMIS; 2007 Jun;115(6):789-94

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinosarcoma ex recurrent pleomorphic adenoma of the submandibular gland.
  • We report a case of carcinosarcoma ex recurrent pleomorphic adenoma in the submandibular region of a 56-year-old Japanese man.
  • He presented with a 2-year history of a rapidly growing mass in the submandibular region.
  • The former large nodule showed a variegated pattern with carcinomatous components (poorly differentiated adenocarcinoma, salivary duct carcinoma, squamous cell carcinoma and undifferentiated carcinoma) and sarcomatous components (spindle cell sarcoma, chondrosarcoma, liposarcoma and rhabdomyosarcoma).
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinosarcoma / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 17550392.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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7. Cheema A, Knights CD, Rao M, Catania J, Perez R, Simons B, Dakshanamurthy S, Kolukula VK, Tilli M, Furth PA, Albanese C, Avantaggiati ML: Functional mimicry of the acetylated C-terminal tail of p53 by a SUMO-1 acetylated domain, SAD. J Cell Physiol; 2010 Nov;225(2):371-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional mimicry of the acetylated C-terminal tail of p53 by a SUMO-1 acetylated domain, SAD.
  • The ubiquitin-like molecule, SUMO-1, a small protein essential for a variety of biological processes, is covalently conjugated to many intracellular proteins, especially to regulatory components of the transcriptional machinery, such as histones and transcription factors.
  • Sumoylation provides either a stimulatory or an inhibitory signal for proliferation and for transcription, but the molecular mechanisms by which SUMO-1 achieves such versatility of effects are incompletely defined.
  • The tumor suppressor and transcription regulator p53 is a relevant SUMO-1 target.
  • Particularly, the C-terminal tail of p53 undergoes both sumoylation and acetylation.
  • While the effects of sumoylation are still controversial, acetylation modifies p53 interaction with chromatin embedded promoters, and enforces p53 apoptotic activity.
  • In this study, we show that the N-terminal region of SUMO-1 might functionally mimic this activity of the p53 C-terminal tail.
  • We found that this SUMO-1 domain possesses similarity with the C-terminal acetylable p53 tail as well as with acetylable domains of other transcription factors.
  • SUMO-1 is, indeed, acetylated when conjugated to its substrates and to p53.
  • In the acetylable form SUMO-1 tunes the p53 response by modifying p53 transcriptional program, by promoting binding onto selected promoters and by favoring apoptosis.
  • By contrast, when non-acetylable, SUMO-1 enforces cell-cycle arrest and p53 binding to a different sets of genes.
  • These data demonstrate for the first time that SUMO-1, a post-translational modification is, in turn, modified by acetylation.
  • Further, they imply that the pleiotropy of effects by which SUMO-1 influences various cellular outcomes and the activity of p53 depends upon its acetylation state.

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
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  • (PMID = 20458745.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R21 CA123234; United States / NCI NIH HHS / CA / R01 CA089041-10; United States / NCI NIH HHS / CA / R21CA123234; United States / NCI NIH HHS / CA / T32 CA009686; United States / NCI NIH HHS / CA / R01 CA089041; United States / NCI NIH HHS / CA / R01 CA102746; United States / NCI NIH HHS / CA / R01 CA083979
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SUMO-1 Protein; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ NIHMS446594; NLM/ PMC3614007
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8. Jaehne M, Dippel A, Sagowski C: [Salivary duct carcinoma of the submandibular gland]. HNO; 2005 Nov;53(11):940-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Salivary duct carcinoma of the submandibular gland].
  • BACKGROUND: Salivary duct carcinoma (SDC) is a rare adenocarcinoma of the salivary glands which usually occurs in the parotid gland (approx.
  • 80%), but is also found in the submandibular gland (approx.
  • Due to the low incidence of this tumour-particularly in terms of involvement of the submandibular and minor salivary glands-only limited clinical data is available.
  • PATIENTS/METHOD: In a retrospective investigation, follow-ups of six patients with a SDC of the submandibular gland were analysed and the surgical measures evaluated for their efficiency.
  • In all patients, the submandibular gland was resected and neck dissection performed, in two cases (33,3%) this was followed by radiotherapy.
  • CONCLUSION: The clinical course of patients with SDC of the submandibular gland exhibits a high (66.6%) rate of local recurrence, crucial for the following clinical course.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Ducts. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Middle Aged. Neck Dissection. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Retrospective Studies. Submandibular Gland / pathology. Submandibular Gland / surgery. Survival Analysis. Survival Rate

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  • (PMID = 15678343.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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9. Yura S, Terahata S, Ohga N, Yamashita T: A case of carcinosarcoma arising in the submandibular gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Jun;103(6):820-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of carcinosarcoma arising in the submandibular gland.
  • A 54-year-old man presented with an 8-year history of a hard asymptomatic mass of the left submandibular area.
  • Total excision of the left submandibular gland with radical neck dissection was performed under a diagnosis of a submandibular tumor, probably a malignant mixed tumor.
  • The epithelial component was composed of squamous cell carcinoma, undifferentiated carcinoma, and adenocarcinoma.
  • [MeSH-major] Carcinosarcoma / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 17531942.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Mizutari K, Naganishi H, Tanaka Y: Oncocytic carcinoma in the submandibular gland: report of a case based on anti-mitochondrial immunohistochemical observations. Auris Nasus Larynx; 2005 Sep;32(3):305-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncocytic carcinoma in the submandibular gland: report of a case based on anti-mitochondrial immunohistochemical observations.
  • Oncocytic carcinoma arising in the submandibular gland is a very rare tumor that has only previously been reported in nine cases.
  • This paper describes an additional case of oncocytic carcinoma in the right submandibular gland.
  • The patient was a 55-year-old Japanese male who was presented with a 3 cm right submandibular mass.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Immunohistochemistry / methods. Mitochondria / immunology. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / pathology

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  • (PMID = 15869853.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies
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11. Mallik S, Agarwal J, Gupta T, Kane S, Laskar SG, Budrukkar A, Murthy V, Goel V, Jain S: Prognostic factors and outcome analysis of submandibular gland cancer: a clinical audit. J Oral Maxillofac Surg; 2010 Sep;68(9):2104-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors and outcome analysis of submandibular gland cancer: a clinical audit.
  • PURPOSE: To retrospectively review a long-term, single-institution experience of subjects with submandibular gland malignancies treated with definitive locoregional therapy with an aim to identify clinicopathologic variables that correlate with outcomes.
  • MATERIALS AND METHODS: A comprehensive chart review of 47 patients presenting to the institute from 1993 to 2005 with a histologic diagnosis of submandibular salivary gland cancer was performed to extract demographic data, clinicopathological characteristics, and treatment details.
  • CONCLUSIONS: Submandibular gland cancer is a rare disease with histologic diversity and variable clinical behavior.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / surgery. Clinical Audit. Submandibular Gland Neoplasms / pathology. Submandibular Gland Neoplasms / surgery

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  • [Copyright] Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20538399.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Adotey JM: Papillary adenocarcinoma of thyroid in a patient with right submandibular mass--a rare case of 'lateral aberrant thyroid'. Niger J Clin Pract; 2009 Sep;12(3):333-4
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  • [Title] Papillary adenocarcinoma of thyroid in a patient with right submandibular mass--a rare case of 'lateral aberrant thyroid'.
  • The occurrence of ectopic thyroid tissue as a mass in the submandibular region is even rarer.
  • AIM: To report a case of papillary adenocarcinoma of thyroid within a right submandibular mass in a 67-year-old man.
  • METHOD: The case notes of the patient, who had presented a year earlier with right submandibular mass, were retrieved and studied.
  • RESULTS: The right submandibular mass had increased in size about 10-fold by the time the patient was seen 13 months later.
  • The neck ultrasound scan demonstrated the presence of a solid right submandibular mass.
  • The FNAB showed papillary adenocarcinoma of the thyroid.
  • CONCLUSION: This patient illustrates the even rarer case of a 'lateral aberrant thyroid' presenting as a malignant submandibular mass.
  • [MeSH-major] Adenocarcinoma / diagnosis. Choristoma / diagnosis. Submandibular Gland Diseases / diagnosis. Thyroid Gland. Thyroid Neoplasms / diagnosis

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  • (PMID = 19803039.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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13. Böckmann RA, Schulz T, Stein H, Mielke E, Dengler K, Wolff KD, Nolte D: Bilateral synchronous submandibular lumps in a patient with gastric carcinoma. J Oral Pathol Med; 2005 Feb;34(2):127-8
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  • [Title] Bilateral synchronous submandibular lumps in a patient with gastric carcinoma.
  • This case report deals with a patient who was readmitted with a bilateral submandibular swelling after having received primary surgery due to gastric adenocarcinoma 6 months before.
  • After bilateral submandibulectomy both glands were diagnosed histopathologically as metastasis of adenocarcinoma.
  • This is the rare case of a submandibular gland metastasis and the first case of a bilateral synchronous submandibular gland metastasis from gastric carcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Stomach Neoplasms / pathology. Submandibular Gland Neoplasms / secondary

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  • (PMID = 15641995.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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14. Munir N, Bradley PJ: Diagnosis and management of neoplastic lesions of the submandibular triangle. Oral Oncol; 2008 Mar;44(3):251-60
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  • [Title] Diagnosis and management of neoplastic lesions of the submandibular triangle.
  • Review of submandibular triangle neoplasms (benign and malignant) treated at a tertiary referral centre in the United Kingdom (1986-2004).
  • Forty nine benign and 58 malignant neoplasms of the submandibular triangle were reviewed.
  • The mainstay treatment for both benign and malignant lesions was surgical either by extracapsular excision of the gland/lesion or selective levels I, IIa and III neck dissection.
  • Submandibular triangle neoplasms are rare and pose many diagnostic and therapeutic challenges.
  • The adequacy of primary surgery is crucial and would support the approach of a more radical excision primarily with a selective levels I, IIa and III neck dissection; ensuring a definitive operation for benign lesions, avoiding the risks of tumour spillage associated with a more limited excision; and removing the primary echelon of lymph nodes at risk of metastasis if the pathology in fact turns out to be malignant; without a significantly higher morbidity in comparison with an extracapsular gland/lesion excision.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Child. Female. Humans. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / surgery. Male. Middle Aged. Retrospective Studies. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / surgery. Treatment Outcome

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  • (PMID = 17467329.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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15. Atsumi T, Fujisawa S, Tonosaki K: Relationship between intracellular ROS production and membrane mobility in curcumin- and tetrahydrocurcumin-treated human gingival fibroblasts and human submandibular gland carcinoma cells. Oral Dis; 2005 Jul;11(4):236-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relationship between intracellular ROS production and membrane mobility in curcumin- and tetrahydrocurcumin-treated human gingival fibroblasts and human submandibular gland carcinoma cells.
  • METHODS: The intracellular ROS production and membrane mobility by curcumin or TH-curcumin were measured in human submandibular adenocarcinoma cells (HSGs) and human primary gingival fibroblasts (HGFs).
  • [MeSH-major] Adenocarcinoma / metabolism. Curcumin / analogs & derivatives. Curcumin / pharmacology. Membrane Fluidity / drug effects. Oxidants / pharmacology. Reactive Oxygen Species / metabolism. Submandibular Gland Neoplasms / metabolism

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  • (PMID = 15984955.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Antioxidants; 0 / Oxidants; 0 / Reactive Oxygen Species; 00U0645U03 / tetrahydrocurcumin; IT942ZTH98 / Curcumin
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16. Mazzullo G, Sfacteria A, Ianelli N, De Majo M, Pennisi MG: Carcinoma of the submandibular salivary glands with multiple metastases in a cat. Vet Clin Pathol; 2005;34(1):61-4
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  • [Title] Carcinoma of the submandibular salivary glands with multiple metastases in a cat.
  • Slides were stained with May-Grünwald Giemsa, and a diagnosis of salivary gland carcinoma was made.
  • At surgery, the tumor was found to involve both submandibular salivary glands as well as adjacent lymph nodes and surrounding tissues.
  • The majority of tissues and organs examined histologically, including mandibular and retropharyngeal lymph nodes, soft palate, laryngopharynx and lungs, contained neoplastic cells whose appearance was consistent with adenocarcinoma.
  • Bilateral salivary adenocarcinoma has not previously been reported in cats, and extensive metastases are rare.

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  • (PMID = 15732021.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Suzuki H, Yamamoto K, Hayashi S, Shindo H, Tonouchi A, Yamamori H: [A case of metastatic submandibular lymphnode treated successfully with palliative oral (5-FU + PSK) chemotherapy in the elderly]. Gan To Kagaku Ryoho; 2005 Jun;32(6):863-5
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  • [Title] [A case of metastatic submandibular lymphnode treated successfully with palliative oral (5-FU + PSK) chemotherapy in the elderly].
  • The pathological diagnosis showed poorly-differentiated adenocarcinoma, si, ly2, v1, n0 (0/41) and Stage IIIa.
  • But a left submandibular lymph node enlarged rapidly within two months after the operation.
  • Aspiration cytology of the lymph node indicated poorly-differentiated adenocarcinoma, and she was diagnosed as recurrent colon cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Lymph Nodes / pathology
  • [MeSH-minor] Administration, Oral. Aged. Aged, 80 and over. Colectomy. Combined Modality Therapy. Drug Administration Schedule. Female. Fluorouracil / administration & dosage. Humans. Lymphatic Metastasis. Palliative Care. Proteoglycans / administration & dosage. Quality of Life. Submandibular Gland

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  • (PMID = 15984533.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Proteoglycans; 66455-27-4 / krestin; U3P01618RT / Fluorouracil
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18. Oudidi A, El-Alami MN, Boulaich M, Jazouli N, Kzadri M: [Primary sub-mandibular gland tumours: experience based on 68 cases]. Rev Laryngol Otol Rhinol (Bord); 2006;127(3):187-90
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  • [Title] [Primary sub-mandibular gland tumours: experience based on 68 cases].
  • Sub-mandibulary gland tumours are less common than tumours of the parotid and pose many clinical and therapeutic challengers.
  • PATIENTS AND METHODS: Retrospective studies of sub-mandibular gland tumours presenting to our department between 1986 and 2000.
  • For malignant lesions (n= 31) the most frequent were: Adenoid cystic carcinoma (n= 10), epidermoid carcinoma (n= 5), adenocarcinoma (n= 5), mucoepidermoid carcinoma (n= 3), malignant non Hodgkinien lymphoma (n= 5).
  • Treatment was by total surgical excision of the submandibular gland for the begnin tumours.
  • CONCLUSION: Malignity in sub-mandibular gland tumours is more frequent than in the parotid gland.
  • [MeSH-major] Submandibular Gland Neoplasms / classification. Submandibular Gland Neoplasms / diagnosis

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  • (PMID = 17007195.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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19. Shimane T, Mori T, Ono T, Egawa S, Furuta A, Ikeda K, Kamakazu K, Kobayashi S, Sanbe T, Suzaki H: [Three cases of adenocarcinoma of the head and neck maintaining QOL by administration of docetaxel]. Gan To Kagaku Ryoho; 2010 Dec;37(13):2897-900
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  • [Title] [Three cases of adenocarcinoma of the head and neck maintaining QOL by administration of docetaxel].
  • A primary head and neck adenocarcinoma is a comparatively rare disease, and surgical resection has been the first choice for its treatment.
  • In the present study, we performed chemotherapy with weekly administration of docetaxel in 3 cases with unresectable or recurrent adenocarcinoma of the head and neck on an outpatient basis, resulting in long-term maintenance of the patients' QOL.
  • Each case had submandibular gland carcinoma, parotid gland carcinoma, or parathyroid gland carcinoma.
  • The present results might suggest that it is possible to treat patients with adenocarcinoma in the head and neck without decreasing patients' QOL.
  • [MeSH-major] Adenocarcinoma / drug therapy. Head and Neck Neoplasms / drug therapy. Taxoids / administration & dosage

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  • (PMID = 21160265.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel
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20. Maiuri F, Gangemi M, Giamundo A, Mariniello G, Colella A, Vergara P, Del Basso De Caro ML: Intracranial extension of salivary gland tumors. Clin Neuropathol; 2010 Jan-Feb;29(1):9-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial extension of salivary gland tumors.
  • OBJECTIVE: The aim of this report is to describe 3 cases of salivary gland tumors with intracranial extension associated to an extracerebral mass lesion, and to discuss the frequence, pathology and treatment of these very rare localizations.
  • The primary tumors were an adenocarcinoma and a malignant oncocytoma of the parotid gland and an adenoid cystic carcinoma of the submandibular gland.
  • CONCLUSIONS: The intracranial extension of salivary gland tumors is a very rare event.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Brain Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 20040327.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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21. Andreadis D, Epivatianos A, Poulopoulos A, Nomikos A, Papazoglou G, Antoniades D, Barbatis C: Detection of C-KIT (CD117) molecule in benign and malignant salivary gland tumours. Oral Oncol; 2006 Jan;42(1):57-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of C-KIT (CD117) molecule in benign and malignant salivary gland tumours.
  • In the present study we analysed the expression of this molecule in salivary gland tumours.
  • Archival formalin-fixed, paraffin-embedded sections of 40 benign and 57 malignant salivary gland tumours were retrieved and retrospectively studied immunohistochemically using a polyclonal C-KIT antibody in an Envision/HRP technique.
  • In addition five samples of chronic submandibular sialadenitis, five normal minor salivary glands and parotid or submandibular gland tissue adjacent to benign tumour were also studied.
  • C-KIT expression was observed in cases of adenoid cystic, acinic cell polymorphous low grade, epithelial-myoepithelial, carcinosarcoma and basal cell adenocarcinomas, as in luminal cells of pleomorphic adenomas, in serous acinar and only in intercalated and a small number of striated ductal cells of inflammatory salivary gland tissue, whereas normal salivary lobules were generally negative except a weak positivity of intercalated cells.
  • Contrary to other reports, this study suggests that, C-KIT protein does not appear to be an exclusively specific marker for benign or malignant salivary gland neoplasms, but may be useful in differential diagnosis of adenoid cystic carcinoma from polymorphous low grade adenocarcinoma.
  • Furthermore its expression in serous acinar cells in sialadenitis and intercalated ductal cells in normal and inflammatory lesions may indicate a possible participation in pathogenesis of both neoplastic and non-neoplastic salivary gland diseases.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. Proto-Oncogene Proteins c-kit / analysis. Salivary Gland Neoplasms / chemistry

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  • (PMID = 16140564.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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22. Li LJ, Li Y, Wen YM, Liu H, Zhao HW: Clinical analysis of salivary gland tumor cases in West China in past 50 years. Oral Oncol; 2008 Feb;44(2):187-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical analysis of salivary gland tumor cases in West China in past 50 years.
  • In our study, 3461 cases of salivary gland tumor treated between 1955 and 2002 at West China Stomatology Hospital of Sichuan University were retrospectively analyzed, and compared with the previous reports.
  • The findings are as follows: the average ages of salivary gland tumor patients were 41.38 years for the benign cases and 45.20 for the malignant ones; the male:female ratio was 0.
  • 99:1 in the benign cases and 1.34:1 in the malignant ones; primary tumors were mostly in the parotid gland, palate and submandibular gland in sequence.
  • Pleomorphic adenoma was the most frequent benign tumor followed by Warthin's tumor and basal cell adenoma, whereas mucoepidermoid carcinoma, adenoid cystic carcinoma and adenocarcinoma not otherwise specified were the most frequent malignant tumors.
  • The incidence of salivary gland tumors increased with age.
  • The parotid gland and palate were the most common locations of salivary gland tumors.
  • [MeSH-major] Adenoma, Pleomorphic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenolymphoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Child. Child, Preschool. China / epidemiology. Female. Humans. Incidence. Infant. Male. Middle Aged. Palatal Neoplasms / pathology. Parotid Neoplasms / pathology. Retrospective Studies

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  • [ErratumIn] Oral Oncol. 2011 Sep;47(9):929-30
  • (PMID = 17418612.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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23. Ansari MH: Salivary gland tumors in an Iranian population: a retrospective study of 130 cases. J Oral Maxillofac Surg; 2007 Nov;65(11):2187-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland tumors in an Iranian population: a retrospective study of 130 cases.
  • PATIENTS AND METHODS: The medical records and case notes of all patients with histologically confirmed salivary gland tumors were reviewed retrospectively from February 1984 to March 2003.
  • Tumors were localized in the parotid gland (63%; n = 82), the submandibular gland (23%; n = 30), and in the minor salivary glands (14%; n = 18).
  • Among malignant tumors, mucoepidermoid carcinoma was the most frequent (11.5%; n = 15), followed by adenocarcinoma (10%; n = 13).
  • CONCLUSION: Between benign and malignant salivary gland tumors, frequency of pleomorphic adenoma and mucoepidermoid carcinoma was in keeping with studies reported previously.
  • In other salivary gland tumors, however, diversity was obvious and showed significant difference, requiring further studies.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Aged. Carcinoma, Mucoepidermoid / epidemiology. Disease-Free Survival. Female. Follow-Up Studies. Humans. Iran / epidemiology. Male. Middle Aged. Neoadjuvant Therapy. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Submandibular Gland Neoplasms / epidemiology. Survival Rate

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  • (PMID = 17954313.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Tian Z, Li L, Wang L, Hu Y, Li J: Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg; 2010 Mar;39(3):235-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population.
  • There is little information in the English-language literature about the epidemiology of salivary gland neoplasms in the eastern Chinese population.
  • Incidences of lymphoepithelial carcinomas (5%) and polymorphous low-grade adenocarcinoma (1%) of malignant tumors were identified.
  • Relatively higher incidences of minor gland tumors and specifically of pleomorphic adenoma in minor glands were noted.
  • There was a high incidence of lymphoepithelial carcinomas but a low incidence of polymorphous low-grade adenocarcinoma.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. China / epidemiology. Female. Humans. Incidence. Male. Middle Aged. Palatal Neoplasms / epidemiology. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Sex Factors. Submandibular Gland Neoplasms / epidemiology. Young Adult

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  • (PMID = 19951834.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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25. Vacchi-Suzzi M, Bocciolini C, Bertarelli C, Dall'Olio D: Ki-67 proliferation rate as a prognostic marker in major salivary gland carcinomas. Ann Otol Rhinol Laryngol; 2010 Oct;119(10):677-83

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ki-67 proliferation rate as a prognostic marker in major salivary gland carcinomas.
  • METHODS: Cell proliferation was evaluated by Mib-1 antibody against Ki-67 antigen in 41 patients with cancer of the parotid or submandibular glands, including 14 acinic cell carcinomas, 12 ductal carcinomas, 7 mucoepidermoid carcinomas, 5 carcinomas ex pleomorphic adenoma, 1 adenoid cystic carcinoma, 1 undifferentiated carcinoma, and 1 polymorphous low-grade adenocarcinoma.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers / analysis. Carcinoma, Acinar Cell / mortality. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Ductal / mortality. Carcinoma, Mucoepidermoid / mortality. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Parotid Neoplasms / mortality. Prognosis. Salivary Gland Neoplasms / mortality. Submandibular Gland Neoplasms / mortality

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  • (PMID = 21049853.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Ki-67 Antigen
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26. Negahban S, Daneshbod Y, Shishegar M: Clear cell carcinoma arising from pleomorphic adenoma of a minor salivary gland: Report of a case with fine needle aspiration, histologic and immunohistochemical findings. Acta Cytol; 2006 Nov-Dec;50(6):687-90
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  • [Title] Clear cell carcinoma arising from pleomorphic adenoma of a minor salivary gland: Report of a case with fine needle aspiration, histologic and immunohistochemical findings.
  • BACKGROUND: Malignant changes in pleomorphic adenoma (PA) of the salivary gland (carcinoma ex pleomorphic adenoma) are not common.
  • Clear cell carcinoma is a rare form of salivary gland tumor and involves mostly minor salivary glands, especially those of the palate.
  • Only 3 cases of clear cell carcinoma arising in PA have been reported, 2 in submandibular glands and 1 in a minor salivary gland of the palate.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenoma, Pleomorphic / pathology. Neoplasms, Second Primary / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 17152285.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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27. Bourke JL, Langer SW, Jensen HL: Metastasizing malignant pleomorphic adenoma in a young man. APMIS; 2007 Jul;115(7):866-8
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  • We present the case of a younger man with metastasizing carcinoma of unknown primary site, where autopsy revealed a malignant pleomorphic adenoma (MPA) of the submandibular gland.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Pleomorphic / diagnosis. Bone Neoplasms / radionuclide imaging. Submandibular Gland Neoplasms / diagnosis

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  • (PMID = 17614856.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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28. Suwała P, Wilczyński K, Barnaś S, Pitala G: [Salivary tumors in the material of the Otolaryngology Clinical Ward of 4th Military Clinical Hospital with the Polyclinic in Wrocław in the years 1992- 2008]. Otolaryngol Pol; 2009 Sep;63(7):54-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: The aim of the study is the analyses of salivary gland tumors on 193 patients who underwent surgery at the Otolaryngology Clinical Ward of 4th Military Clinical Hospital with the Polyclinic in Wrocław in the years 1992-2008.
  • MATERIAL AND METHODS: In the group of patients with salivary gland tumors, which were analysed, there were 106 woman (54.9%) and 87 men (45.1%).
  • RESULTS AND CONCLUSIONS: Tumors located in 48.7% in parotid gland, 49.7% in submandibular salivary gland and 1.6% in hypoglossal salivary gland.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Adenoma / epidemiology. Adenoma / surgery. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adenoma, Pleomorphic / epidemiology. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Mucoepidermoid / surgery. Female. Follow-Up Studies. Hospitals, Military. Humans. Male. Middle Aged. Parotid Neoplasms / epidemiology. Parotid Neoplasms / surgery. Poland / epidemiology. Retrospective Studies. Salivary Glands / surgery. Sex Distribution. Submandibular Gland Neoplasms / epidemiology. Submandibular Gland Neoplasms / surgery. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 20564902.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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29. Paksoy N: Ectopic lesions as potential pitfalls in fine needle aspiration cytology: a report of 3 cases derived from the thyroid, endometrium and breast. Acta Cytol; 2007 Mar-Apr;51(2):222-6

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  • Upon diagnosis of a submandibular mass with a diameter of 1 cm, FNAC was performed.
  • The case was diagnosed on FNAC as low grade malignancy in which an adenocarcinoma/mesenchymal tumor distinction could not be made.
  • [MeSH-major] Breast / pathology. Choristoma / pathology. Diagnostic Errors / prevention & control. Endometrium / pathology. Thyroid Gland / pathology
  • [MeSH-minor] Abdominal Wall / pathology. Abdominal Wall / physiopathology. Adult. Axilla / pathology. Axilla / physiopathology. Biopsy, Fine-Needle. Diagnosis, Differential. Endometriosis / pathology. Female. Humans. Neoplasms / pathology. Neoplasms / physiopathology. Submandibular Gland / pathology. Thyroiditis / complications. Thyroiditis / pathology. Thyroiditis / physiopathology

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  • (PMID = 17425209.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Hattori T, Wang PL: Calcium antagonists cause dry mouth by inhibiting resting saliva secretion. Life Sci; 2007 Aug 2;81(8):683-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Since the intracellular Ca2+ concentration ([Ca2+]i) is closely related to saliva secretion, [Ca2+]i was measured with a video-imaging analysis system by using human submandibular gland (HSG) cells as the material.
  • [MeSH-minor] 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / pharmacology. Adenocarcinoma / metabolism. Calcium / metabolism. Calcium Channel Agonists / pharmacology. Carbachol / pharmacology. Cell Line, Tumor. Depression, Chemical. Endothelin-1 / pharmacology. Humans. Imidazoles / pharmacology. Isoenzymes / metabolism. Microscopy, Fluorescence. Muscarinic Agonists / pharmacology. Norepinephrine / pharmacology. Phospholipase C beta. Submandibular Gland Neoplasms / metabolism. Type C Phospholipases / metabolism. Vasoconstrictor Agents / pharmacology

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  • (PMID = 17688889.001).
  • [ISSN] 0024-3205
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calcium Channel Agonists; 0 / Calcium Channel Blockers; 0 / Endothelin-1; 0 / Imidazoles; 0 / Isoenzymes; 0 / Muscarinic Agonists; 0 / Vasoconstrictor Agents; 130495-35-1 / 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole; 71145-03-4 / 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8Y164V895Y / Carbachol; EC 3.1.4.- / Type C Phospholipases; EC 3.1.4.11 / Phospholipase C beta; SY7Q814VUP / Calcium; X4W3ENH1CV / Norepinephrine
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31. Giannini PJ, Shetty KV, Horan SL, Reid WD, Litchmore LL: Adenoid cystic carcinoma of the buccal vestibule: A case report and review of the literature. Oral Oncol; 2006 Nov;42(10):1029-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Minor salivary gland tumors of the buccal vestibule are relatively rare.
  • Adenoid cystic carcinoma is the fifth most common salivary gland malignancy following mucoepidermoid carcinoma, adenocarcinoma not otherwise specified (NOS), acinic cell adenocarcinoma and polymorphous low-grade adenocarcinoma (PLGA).
  • Greater than half of adenoid cystic carcinomas occur in the parotid and submandibular glands.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Mouth Neoplasms / pathology. Salivary Gland Neoplasms / pathology


32. Seethala RR, Hunt JL, Baloch ZW, Livolsi VA, Leon Barnes E: Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol; 2007 Nov;31(11):1683-94
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  • The most commonly involved sites were sinonasal (4/11) and submandibular (4/11).
  • The most common morphologies for the high-grade component were poorly differentiated cribriform adenocarcinoma and solid undifferentiated carcinoma.
  • ACC-high-grade transformation is a highly aggressive salivary gland tumor with a variety of histologic patterns.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Papillary / pathology. Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18059225.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin D; 0 / Cyclins; 0 / Ki-67 Antigen; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Number-of-references] 53
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33. Furuse C, Miguita L, Rosa AC, Soares AB, Martinez EF, Altemani A, de Araújo VC: Study of growth factors and receptors in carcinoma ex pleomorphic adenoma. J Oral Pathol Med; 2010 Aug 1;39(7):540-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Carcinoma ex pleomorphic adenoma (CXPA) is a rare malignant salivary gland tumor derived from a pre-existing pleomorphic adenoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Intercellular Signaling Peptides and Proteins / analysis. Parotid Neoplasms / pathology. Receptors, Growth Factor / analysis
  • [MeSH-minor] Adult. Aged. Carcinoma in Situ / pathology. Cell Proliferation. Coloring Agents. Disease Progression. Epithelial Cells / pathology. Female. Fibroblast Growth Factors / analysis. Hepatocyte Growth Factor / analysis. Humans. Male. Middle Aged. Neoplasm Invasiveness. Protein-Serine-Threonine Kinases / analysis. Proto-Oncogene Proteins c-met / analysis. Receptor, Epidermal Growth Factor / analysis. Receptor, Fibroblast Growth Factor, Type 1 / analysis. Receptor, Fibroblast Growth Factor, Type 2 / analysis. Receptor, IGF Type 1 / analysis. Receptors, Transforming Growth Factor beta / analysis. Submandibular Gland Neoplasms / pathology. Transforming Growth Factor beta1 / analysis

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  • (PMID = 20149060.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Intercellular Signaling Peptides and Proteins; 0 / Receptors, Growth Factor; 0 / Receptors, Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1; 62031-54-3 / Fibroblast Growth Factors; 67256-21-7 / Hepatocyte Growth Factor; EC 2.7.10.1 / FGFR1 protein, human; EC 2.7.10.1 / FGFR2 protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-met; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 2; EC 2.7.10.1 / Receptor, IGF Type 1; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / transforming growth factor-beta type II receptor
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34. Deshpande V, Chicano S, Finkelberg D, Selig MK, Mino-Kenudson M, Brugge WR, Colvin RB, Lauwers GY: Autoimmune pancreatitis: a systemic immune complex mediated disease. Am J Surg Pathol; 2006 Dec;30(12):1537-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A control cohort composed of pancreatic adenocarcinoma (n=19) and chronic pancreatitis-not otherwise specified (NOS) (n=14) was also evaluated.
  • The pancreas, bile duct, gall bladder, salivary gland, kidney, and lung lesions were characterized by dense lymphoplasmacytic infiltrates with reactive fibroblasts and venulitis.
  • The AIP cases showed significantly more pancreatic IgG4 positive plasma cells than chronic pancreatitis-NOS or adenocarcinoma (P=0.001).
  • However, IgG4 positive cells were identified in 57.1% of chronic pancreatitis-NOS and 47.4% of ductal adenocarcinoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigen-Antibody Complex / immunology. Antigen-Antibody Complex / ultrastructure. Biomarkers / metabolism. Cell Count. Female. Humans. Immunoenzyme Techniques. Immunoglobulin G / metabolism. Kidney / metabolism. Kidney / pathology. Male. Middle Aged. Pancreas / metabolism. Pancreas / pathology. Pancreas / ultrastructure. Pancreatectomy. Plasma Cells / metabolism. Plasma Cells / pathology. Submandibular Gland / pathology

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  • [ErratumIn] Am J Surg Pathol. 2007 Feb;31(2):328. Chiocca, Sonia [corrected to Chicano, Sonia]
  • (PMID = 17122509.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigen-Antibody Complex; 0 / Biomarkers; 0 / Immunoglobulin G
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35. Stodulski D, Rzepko R, Kowalska B, Stankiewicz C: [Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review]. Otolaryngol Pol; 2007;61(5):687-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In 15 cases, tumor was localized in the parotid and in 4 in the submandibular gland.
  • The most common malignant component in CXPA was adenocarcinoma (9 cases) and undifferentiated carcinoma (6 cases).
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • (PMID = 18552001.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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36. Borges A, Martins M, André S: Double thyroid ectopia (with incidental papillary thyroid microcarcinoma) (2010: 8b). Eur Radiol; 2010 Nov;20(11):2768-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present the case of a 45-year-old man with a long-standing history of a slow-growing left submandibular mass.
  • Imaging was diagnostic as it disclosed an absent orthotopic thyroid gland and heterogeneous masses, with both solid and cystic components, as well as calcifications in the left sublingual/submandibular space and in the left paramedian aspect of the tongue base, consistent with double thyroid ectopia, originating from central and lateral thyroid anlages, respectively.
  • Pathology confirmed an ectopic thyroid goiter in the left submandibular space with an incidental papillary microcarcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Choristoma / diagnosis. Neck. Thyroid Dysgenesis / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 20886341.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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37. Matsuda K, Doi T, Kosaka H, Tasaki N, Yoshioka H, Kakibuchi M: Sebaceous carcinoma arising in nevus sebaceus. J Dermatol; 2005 Aug;32(8):641-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A wide local excision of the area including a superficial parotidectomy and submandibular lymph node dissection was performed, followed by full thickness skin grafting.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Nevus / diagnosis. Sebaceous Gland Neoplasms / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 16334864.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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38. Singh J, Naran A, Misso NL, Rigby PJ, Thompson PJ, Bhoola KD: Expression of kallikrein-related peptidases (KRP/hK5, 7, 6, 8) in subtypes of human lung carcinoma. Int Immunopharmacol; 2008 Feb;8(2):300-6
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  • Using specific antibodies, expression of these KRP/hK was determined in archived lung tumour sections of the four subtypes, and in normal skin, brain, lung and submandibular gland tissue sections.
  • In the adenocarcinoma there was no cytoplasmic labelling for any of the KRP/hK, but the nuclei of 20% of the tumour cells were labelled for KRP/hK5, 7 and 8 (intensity grade 2+/3+).

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  • (PMID = 18182244.001).
  • [ISSN] 1567-5769
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 3.4.21.- / KLK5 protein, human; EC 3.4.21.- / KLK6 protein, human; EC 3.4.21.- / KLK7 protein, human; EC 3.4.21.- / KLK8 protein, human; EC 3.4.21.- / Kallikreins
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39. Wechalekar K, Haq M, Harmer C, Cook G: Metastatic thyroid carcinoma causing superior vena caval obstruction diagnosed on I-131 scan. Clin Nucl Med; 2005 Aug;30(8):548-9
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  • Total thyroidectomy was performed with evidence of tumor infiltration into the strap muscles extending up to the right submandibular gland and right internal jugular vein, which was completely occluded.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Head and Neck Neoplasms / secondary. Superior Vena Cava Syndrome / etiology. Thyroid Neoplasms / pathology

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  • (PMID = 16024951.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals
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40. Hébert-Blouin MN, Chowdhry SA, Abrahams PH, Spinner RJ: An unusual anatomical explanation for contralateral upper extremity weakness after frontal craniotomy. Clin Anat; 2009 Oct;22(7):840-5
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  • The cause of the neck edema was found to be sialadenitis of the submandibular gland.
  • [MeSH-minor] Adenocarcinoma / surgery. Brain Neoplasms / surgery. Female. Humans. Middle Aged

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19718769.001).
  • [ISSN] 1098-2353
  • [Journal-full-title] Clinical anatomy (New York, N.Y.)
  • [ISO-abbreviation] Clin Anat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Mukhopadhyay S, Mukherjee S, Das SK: Increased expression of peripheral benzodiazepine receptor (PBR) in dimethylbenz[a]anthracene-induced mammary tumors in rats. Glycoconj J; 2006 May;23(3-4):199-207
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  • Our laboratory reported earlier a significant increase of PBR density in the nucleus of DMBA-induced malignant submandibular glands of rats, suggesting a role of PBR in nuclear events of peripheral tissues.
  • In conclusion, these data suggest that PBR ligand binding, and PBR-mediated cholesterol transport into the nucleus may be involved in the development of mammary gland adenocarcinoma, thus participating in the advancement of the disease.

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  • (PMID = 16691503.001).
  • [ISSN] 0282-0080
  • [Journal-full-title] Glycoconjugate journal
  • [ISO-abbreviation] Glycoconj. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzodiazepinones; 0 / Carcinogens; 0 / Carrier Proteins; 0 / Receptors, GABA-A; 141440-82-6 / Tspo protein, rat; 14439-61-3 / 4'-chlorodiazepam; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; 97C5T2UQ7J / Cholesterol; EC 3.6.1.15 / Nucleoside-Triphosphatase
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42. Lee WY, Chang SL: Fine needle aspiration cytology of oncocytic carcinoma of the submandibular gland with pre-existing oncocytoma: a case report. Cytopathology; 2010 Oct;21(5):339-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytology of oncocytic carcinoma of the submandibular gland with pre-existing oncocytoma: a case report.
  • [MeSH-major] Adenocarcinoma / secondary. Adenoma, Oxyphilic / pathology. Neoplasms, Second Primary / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 20015258.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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43. Scholz N, Krugmann J, Scholtz A, Höllrigl A, Verdorfer I: Genetic alterations in a basal cell adenocarcinoma of the glandula submandibularis. Cancer Genet Cytogenet; 2007 Jan 1;172(1):87-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic alterations in a basal cell adenocarcinoma of the glandula submandibularis.
  • [MeSH-major] Adenocarcinoma / genetics. Submandibular Gland Neoplasms / genetics

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  • (PMID = 17175388.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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