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Items 1 to 100 of about 4370
1. Usui S, Hiranuma S, Ichikawa T, Maeda M, Kudo SE, Iwai T: Preoperative imaging of surrounding arteries by three-dimensional CT: is it useful for laparoscopic gastrectomy? Surg Laparosc Endosc Percutan Tech; 2005 Apr;15(2):61-5
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  • One of the difficulties in laparoscopic gastrectomy is the identification of the feeding artery of the stomach.
  • Recently, 3-dimensional computed tomographic angiography has enabled the noninvasive visualization of arteries surrounding the stomach.
  • Preoperative 3-dimensional computed tomographic angiography may facilitate laparoscopic gastrectomy by obtaining a road map of the arteries of the stomach.
  • Twenty-nine cases of gastric cancer were evaluated using 3-dimensional computed tomographic angiography before surgery.
  • Three-dimensional computed tomographic angiography showed the left gastric artery in 29 patients (100%), the right gastroepiploic artery in 29 patients (100%), the right gastric artery in 24 patients (82.8%), and the left gastroepiploic artery in 21 patients (72.4%).
  • The aberrant hepatic artery was detected in 6 patients, and the variant of the right gastric artery and the variant of the left gastric artery were detected in 5 cases and 1 case, respectively.
  • [MeSH-major] Adenocarcinoma / surgery. Angiography. Gastrectomy / methods. Imaging, Three-Dimensional. Laparoscopy / methods. Preoperative Care / methods. Stomach Neoplasms / surgery. Tomography, X-Ray Computed

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  • (PMID = 15821615.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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2. Pantidou A, Kiziridou A, Antoniadis T, Tsilikas C, Destouni C: Mediastinum thymoma diagnosed by FNA and ThinPrep technique: a case report. Diagn Cytopathol; 2006 Jan;34(1):37-40
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  • This is an interesting case of thymoma diagnosed by fine-needle aspiration biopsy (FNA) and ThinPrep technique, in a 54-year-old female patient with a history of gastric adenocarcinoma.
  • The tumor was excised and the histopathological examination supported the cytological diagnosis.
  • Thymomas commonly constitute a problem in differential diagnosis of mediastinum masses.
  • [MeSH-major] Biopsy, Fine-Needle. Mediastinal Neoplasms / diagnosis. Thymoma / diagnosis. Thymoma / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Female. Histocytological Preparation Techniques. Humans. Middle Aged. Neoplasms, Second Primary / diagnosis. Stomach Neoplasms / pathology

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  • (PMID = 16355373.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Tanabe H, Hara H, Ohtubo C, Miyokawa N, Sano H: [Disappearance of gastric adenocarcinoma in hyperplastic polyp after eradication of Heliobacter pylori. Report of a case]. Nihon Shokakibyo Gakkai Zasshi; 2005 May;102(5):559-63
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  • [Title] [Disappearance of gastric adenocarcinoma in hyperplastic polyp after eradication of Heliobacter pylori. Report of a case].
  • [MeSH-major] Adenocarcinoma / microbiology. Anti-Bacterial Agents / administration & dosage. Helicobacter Infections / drug therapy. Helicobacter pylori. Polyps / microbiology. Stomach Neoplasms / microbiology

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  • (PMID = 15920952.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; H1250JIK0A / Clarithromycin; KG60484QX9 / Omeprazole
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4. Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES: [Double strand break of DNA in gastric adenoma and adenocarcinoma]. Korean J Gastroenterol; 2010 Jan;55(1):19-25
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  • [Title] [Double strand break of DNA in gastric adenoma and adenocarcinoma].
  • The aim of this study was to define the differences in expression of 53BP1 and gamma-H2AX, the markers of DSB, among normal, gastric adenoma, and gastric adenocarcinoma tissues.
  • METHODS: Tissue microarray was made with the tissues taken from 121 patients who underwent gastrectomy for gastric adenocarcinoma, and 51 patients who underwent endoscopic mucosal resection for gastric adenoma.
  • The normal tissues were collected from histologically confirmed tissues with no cellular atypia obtained from the patients with gastric adenocarcinoma.
  • RESULTS: In gastric carcinoma cells, 53BP1 and gamma-H2AX were highly expressed as compared to normal epithelial cells and gastric adenoma (p<0.01).
  • There were no differences in the expression of 53BP1 and gamma-H2AX between normal epithelium and gastric adenoma.
  • The expression of 53BP1 and gamma-H2AX were not significantly different according to the clinicopathologic parameters in the patients with gastric adenocarcinoma.
  • CONCLUSIONS: The DSB in DNA seems to be associated with the development of gastric adenocarcinoma, but does not affect the premalignant adenoma cells.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. DNA Breaks, Double-Stranded. Stomach Neoplasms / metabolism

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  • (PMID = 20098063.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / H2AFX protein, human; 0 / Histones; 0 / Intracellular Signaling Peptides and Proteins; 0 / TP53BP1 protein, human; 0 / Tumor Suppressor p53-Binding Protein 1
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5. Castellan M, Gosalbez R, Perez-Brayfield M, Healey P, McDonald R, Labbie A, Lendvay T: Tumor in bladder reservoir after gastrocystoplasty. J Urol; 2007 Oct;178(4 Pt 2):1771-4; discussion 1774
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  • PURPOSE: To our knowledge the risk of malignancy in patients with previous bladder augmentation with stomach is unknown.
  • We report 3 cases of gastric adenocarcinoma and 1 of transitional cell carcinoma after augmentation cystoplasty with stomach with long-term followup.
  • MATERIALS AND METHODS: Between August 1989 and August 2002, 119 patients underwent augmentation cystoplasty with stomach at our 2 institutions (University of Miami School of Medicine, and Seattle Children's Hospital and Regional Medical Center).
  • Preoperative diagnosis was neurogenic bladder in 3 patients and posterior urethral valve in 1.
  • Three patients had gastric adenocarcinoma, while the other had poorly differentiated transitional cell carcinoma.
  • CONCLUSIONS: Patients who undergo bladder augmentation with a gastric remnant are at increased risk for malignancy, probably similar to that in patients with enterocystoplasty.
  • Patients should be followed annually with ultrasound, and cystoscopy should be performed annually starting 10 years after gastrocystoplasty unless they have abnormal ultrasound, hematuria or another cancer risk factor.
  • [MeSH-major] Adenocarcinoma / etiology. Carcinoma, Transitional Cell / etiology. Gastric Mucosa / transplantation. Urinary Bladder Neoplasms / etiology. Urinary Diversion / adverse effects. Urinary Reservoirs, Continent / adverse effects

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  • (PMID = 17707009.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Wu J, He YJ, Tong SL: [Gastric collision tumor (adenocarcinoma and gastrointestinal stromal tumor): report of a case]. Zhonghua Bing Li Xue Za Zhi; 2010 Aug;39(8):563-4
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  • [Title] [Gastric collision tumor (adenocarcinoma and gastrointestinal stromal tumor): report of a case].
  • [MeSH-major] Adenocarcinoma / pathology. Gastrointestinal Stromal Tumors / pathology. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology

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  • (PMID = 21055041.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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7. Xu CY, Guo JL, Jiang ZN, Xie SD, Shen JG, Shen JY, Wang LB: Prognostic role of estrogen receptor alpha and estrogen receptor beta in gastric cancer. Ann Surg Oncol; 2010 Sep;17(9):2503-9
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  • [Title] Prognostic role of estrogen receptor alpha and estrogen receptor beta in gastric cancer.
  • BACKGROUND: The presence of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) have been reported in cell and tissue level in gastric cancer, but its impact on patients' survival remains unclear.
  • This study was designed to investigate the expression level of ERalpha and ERbeta and to assess clinical significance of ERalpha and ERbeta expression in gastric cancer.
  • METHODS: The expression level of ERalpha and ERbeta were assessed by reverse-transcriptase polymerase chain reaction (RT-PCR) in 35 surgically resected gastric cancer and corresponding normal tissues and by immunohistochemical staining in 211 surgically resected gastric cancer and match normal tissues.
  • RESULTS: The expression level between ERalpha mRNA expression in gastric cancer tissues and match normal tissues had no statistically significant difference.
  • The ERbeta mRNA level in normal tissues was significantly higher than that observed in gastric cancer tissues (P = 0.001).
  • Forty-eight of 211 (22.7%) gastric cancer tissues showed positive expression of ERalpha and ERbeta detected in gastric cancer.
  • ERalpha-positive expression correlated with poorer overall survival (P = 0.014), as did the absence of ERbeta expression in patients with gastric cancer (P = 0.001).
  • CONCLUSIONS: Our results indicated that ERalpha and ERbeta were expressed in both gastric cancer and corresponding normal tissues.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Estrogen Receptor alpha / metabolism. Estrogen Receptor beta / metabolism. Gastric Mucosa / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 20339947.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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8. Soung YH, Lee JW, Kim SY, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH: Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas. APMIS; 2006 Apr;114(4):292-7
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  • Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development.
  • To explore the possibility that the genetic alterations of caspase-9 might be involved in the development of human cancers, we analyzed the entire coding region and all splice sites of the human caspase-9 gene for the detection of somatic mutations in a series of 353 cancers, including 180 gastric, 104 colorectal and 69 lung adenocarcinomas.
  • The mutations were observed in 2 of 104 colorectal carcinomas and 1 of 180 gastric carcinomas.
  • These data indicate that the caspase-9 gene is rarely mutated in gastric, colorectal and lung adenocarcinomas, and suggest that caspase-9 gene mutation may not contribute to the pathogenesis of these cancers.
  • [MeSH-major] Adenocarcinoma / genetics. Apoptosis / genetics. Caspases / genetics. Colonic Neoplasms / genetics. Lung Neoplasms / genetics. Stomach Neoplasms / genetics

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  • (PMID = 16689829.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 3.4.22.- / CASP9 protein, human; EC 3.4.22.- / Caspase 9; EC 3.4.22.- / Caspases
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9. Li JH, Shi XZ, Liu M, Wang Y, Yu ZH, Xu GW, Lu S: [Methylation of hMLH1 gene promoter in gastric carcinoma with microsatellite instability]. Ai Zheng; 2005 Mar;24(3):273-7
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  • [Title] [Methylation of hMLH1 gene promoter in gastric carcinoma with microsatellite instability].
  • Our previous study showed that loss of MMR protein expression can also be seen in gastric carcinoma, but MMR gene mutation seldom occur.
  • This study was designed to investigate the relationship of hMLH1 gene promoter methylation status to MSI in gastric carcinoma, and analyze its action as a risk factor of carcinogenesis.
  • METHODS: DNA was extracted from 52 samples of gastric carcinoma and their adjacent non-cancerous gastric mucosa.
  • RESULTS: Of the 52 specimens of gastric carcinoma, 13 with high MSI (MSI-H), 2 with low MSI (MSI-l), and 37 with microsatellite stability (MSS).
  • Frequency of hMLH1 promoter methylation was significantly higher in the 13 specimens of gastric carcinoma with MSI-H than in the 39 specimens of gastric carcinoma with MSI-L or MSS (100% vs. 2.6%, P<0.01).
  • Furthermore, frequency of hMLH1 promoter methylation was significantly higher in the 13 specimens of adjacent non-cancerous gastric mucosa of gastric carcinoma with MSI-H than in the 39 specimens of adjacent non-cancerous gastric mucosa of gastric carcinoma with MSI-L or MSS (46.2% vs. 2.6%, P<0.01).
  • Methylation of hMLH1 gene promoter had no relation with differentiation and clinical stage of gastric carcinoma.
  • CONCLUSION: Methylation of hMLH1 gene promoter exists in gastric carcinoma tissues with MSI-H, and their adjacent non-cancerous gastric mucosa, it may be a risk factor of carcinogenesis of gastric carcinoma.
  • [MeSH-major] Carrier Proteins / metabolism. DNA Methylation. DNA Repair / genetics. Microsatellite Repeats / genetics. Nuclear Proteins / metabolism. Stomach Neoplasms / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adult. Aged. Female. Gastric Mucosa / metabolism. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Neoplasm Staging. Promoter Regions, Genetic

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  • (PMID = 15757526.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins
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10. Mariette C: [A case of stomach cancer]. J Chir (Paris); 2005 May-Jun;142(3):184-6
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  • [Title] [A case of stomach cancer].
  • [Transliterated title] Un cancer de l'estomac.
  • [MeSH-major] Adenocarcinoma. Pyloric Antrum. Stomach Neoplasms

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  • (PMID = 16142084.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Cadherins
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11. Schmeda-Hirschmann G, Pertino MW, Rodriguez JA, Monsalve F, Droguett D, Theoduloz C: Synthesis, gastroprotective effect and cytotoxicity of new amino acid diterpene monoamides and diamides. Molecules; 2010;15(10):7378-94
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  • The new compounds were evaluated for their gastroprotective effect in the ethanol/HCl-induced gastric lesions model in mice, as well as for cytotoxicity using the following human cell lines: normal lung fibroblasts (MRC-5), gastric adenocarcinoma cells (AGS) and liver hepatocellular carcinoma (Hep G2).
  • A dose-response experiment showed that at 25 mg/kg the C-15 leucyl and C-15,19-dileucylester amides of junicedric acid reduced gastric lesions by about 65.6 and 49.6%, respectively, with an effect comparable to lansoprazole at 20 mg/kg (79.3% lesion reduction).
  • Several compounds presented a strong gastroprotective effect, reducing gastric lesions in the 70.9-87.8% range.
  • [MeSH-major] Amino Acids. Diamide. Diterpenes. Stomach Ulcer / drug therapy
  • [MeSH-minor] Animals. Cell Line. Ethanol / pharmacology. Gastric Mucosa / pathology. Humans. Male. Mice. Molecular Structure

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  • (PMID = 20966879.001).
  • [ISSN] 1420-3049
  • [Journal-full-title] Molecules (Basel, Switzerland)
  • [ISO-abbreviation] Molecules
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Diterpenes; 0 / diterpene 8(17)-labden-15,19-dioic acid; 10465-78-8 / Diamide; 3K9958V90M / Ethanol
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12. Lim JY, Cho JY, Paik YH, Lee DK, Lee SI, Park HJ, Lee SJ, Lee KS, Yoon DS, Choi SH: Salvage chemotherapy with docetaxel and epirubicin for advanced/metastatic gastric cancer. Oncology; 2007;73(1-2):2-8
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  • [Title] Salvage chemotherapy with docetaxel and epirubicin for advanced/metastatic gastric cancer.
  • BACKGROUND: We conducted a phase II study to assess the efficacy and tolerability of docetaxel and epirubicin as salvage chemotherapy in advanced/metastatic gastric cancer patients with documented progression after 5-fluorouracil/platinum-based combination chemotherapy.
  • Twenty-six patients had locally advanced or metastatic disease at the time of diagnosis, and 8 patients had recurrent disease after surgical resection of the primary tumor.
  • CONCLUSION: A combination of chemotherapy with docetaxel and epirubicin showed moderate activity as salvage treatment in advanced/metastatic gastric cancer, especially in patients who had responded to prior chemotherapy.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Salvage Therapy / methods. Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18332648.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / Platinum Compounds; 0 / Taxoids; 15H5577CQD / docetaxel; 3Z8479ZZ5X / Epirubicin; U3P01618RT / Fluorouracil
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13. Catalano G, Urbani L, De Simone P, Morelli L, Coletti L, Cioni R, Matocci G, Mosca F, Filipponi F: Expanding indications for TIPSS: portal decompression before elective oncologic gastric surgery in cirrhotic patients. J Clin Gastroenterol; 2005 Nov-Dec;39(10):921-3
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  • [Title] Expanding indications for TIPSS: portal decompression before elective oncologic gastric surgery in cirrhotic patients.
  • [MeSH-major] Elective Surgical Procedures. Gastrectomy. Hypertension, Portal / prevention & control. Liver Cirrhosis, Alcoholic / surgery. Portasystemic Shunt, Transjugular Intrahepatic. Stomach Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Esophageal and Gastric Varices / surgery. Humans. Male. Middle Aged. Preoperative Care. Stomach Ulcer / surgery

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  • (PMID = 16208123.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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14. Im M, Kye KC, Kim JM, Lee JH: Extramammary Paget's disease of the scrotum with adenocarcinoma of the stomach. J Am Acad Dermatol; 2007 Aug;57(2 Suppl):S43-5
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  • [Title] Extramammary Paget's disease of the scrotum with adenocarcinoma of the stomach.
  • [MeSH-major] Adenocarcinoma / pathology. Paget Disease, Extramammary / pathology. Scrotum. Skin Neoplasms / pathology. Stomach Neoplasms / pathology

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  • (PMID = 17637372.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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15. Ullah MZ, Patel H, Lauffer GL, Tanner A: Second case report of a metachronous double primary gastric cancer. Br J Hosp Med (Lond); 2005 Sep;66(9):538-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Second case report of a metachronous double primary gastric cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Non-Hodgkin / surgery. Neoplasms, Second Primary / surgery. Stomach Neoplasms / drug therapy

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  • (PMID = 16200801.001).
  • [ISSN] 1750-8460
  • [Journal-full-title] British journal of hospital medicine (London, England : 2005)
  • [ISO-abbreviation] Br J Hosp Med (Lond)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. Schneider F, Lang N, Reibke R, Michaely HJ, Hiddemann W, Ostermann H: Plesiomonas shigelloides pneumonia. Med Mal Infect; 2009 Jun;39(6):397-400
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  • We report the first case of pneumonia caused by P. shigelloides in a 76-year-old woman who had undergone a curative gastrectomy and esophageal-jejunostomy due to a low differentiated adenocarcinoma of the stomach (pT2, pN1 pMx, G3, R0, Lauren: intestinal type).
  • Although antibiotic treatment led to a decrease of inflammation parameters and decrease of the pulmonary infiltrate the patient died due to development of torsades de pointes tachycardia leading to ventricular fibrillation and hypoxic brain damage.
  • [MeSH-major] Adenocarcinoma / surgery. Gastrectomy / adverse effects. Gram-Negative Bacterial Infections / etiology. Jejunostomy / adverse effects. Plesiomonas. Stomach Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Inflammation / microbiology. Tachycardia / etiology. Torsades de Pointes / etiology. Unconsciousness / etiology. Ventricular Fibrillation / etiology

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  • (PMID = 19167851.001).
  • [ISSN] 0399-077X
  • [Journal-full-title] Médecine et maladies infectieuses
  • [ISO-abbreviation] Med Mal Infect
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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17. Ran JT, Zhou YN, Tang CW, Lu JR, Wu J, Lu H, Yang GD: [Celecoxib induces apoptosis and inhibits angiogenesis in gastric cancer]. Zhonghua Zhong Liu Za Zhi; 2008 Jun;30(6):448-51
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  • [Title] [Celecoxib induces apoptosis and inhibits angiogenesis in gastric cancer].
  • OBJECTIVE: The aim of this study was to explore the effect of celecoxib, a cyclooxygenase-2 inhibitor, on induction of apoptosis and inhibition of angiogenesis in gastric cancer.
  • METHODS: Fifty nine gastric cancer patients were randomly divided into 2 groups: celecoxib group (n = 37) and control group (n = 22).
  • The expression level of COX-2 and VEGF in the gastric cancer tissues was significantly decreased in the celecoxib group compared with those in the control group (P < 0.05).
  • CONCLUSION: Oral intake of celecoxib can induce apoptosis and suppress angiogenesis in gastric cancer.
  • It may become an effective agent in the treatment of gastric cancer.
  • [MeSH-major] Apoptosis / drug effects. Cyclooxygenase 2 Inhibitors / pharmacology. Neovascularization, Pathologic / prevention & control. Pyrazoles / pharmacology. Stomach Neoplasms / pathology. Sulfonamides / pharmacology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adult. Aged. Celecoxib. Cyclooxygenase 2 / metabolism. Female. Humans. Male. Microvessels / pathology. Microvessels / ultrastructure. Middle Aged. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 19024521.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; 0 / Vascular Endothelial Growth Factor A; EC 1.14.99.1 / Cyclooxygenase 2; JCX84Q7J1L / Celecoxib
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18. Spiliotis J, Karnabatidis D, Vaxevanidou A, Datsis AC, Rogdakis A, Zacharis G, Siamblis D: Acute cholangitis due to afferent loop syndrome after a Whipple procedure: a case report. Cases J; 2009;2:6339
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  • INTRODUCTION: Patients with resection of stomach and especially with Billroth II reconstruction (gastro jejunal anastomosis), are more likely to develop afferent loop syndrome which is a rare complication.
  • CASE PRESENTATION: A 54-year-old Greek male had undergone a pancreato-duodenectomy (Whipple procedure) one year earlier due to a pancreatic adenocarcinoma.
  • The diagnosis is difficult and the interventional radiology gives all the details to support the therapeutic decision making.

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  • [Cites] Eur Radiol. 2008 Mar;18(3):448-56 [17960388.001]
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  • (PMID = 19918578.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2769288
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19. Peng SY, Hong DF, Liu YB, Li JT, Tao F, Tan ZJ: [A pancreas suture-less type II binding pancreaticogastrostomy]. Zhonghua Wai Ke Za Zhi; 2009 Dec 1;47(23):1764-6
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  • METHODS: From November 2008 to May 2009, 26 patients underwent pancreaticoduodenectomy and mid-segmentectomy of pancreas with type II BPG reconstruction, including 13 cases of pancreatic head cancer, 3 cases of duodenal adenocarcinoma, 2 cases of ampullary carcinoma, 4 cases of cholangiocarcinoma, 1 case of bile duct cell severe atypical hyperplasia, and 1 case of stomach cancer.
  • The process of type II BPG was described as the following: after pancreas remnant was mobilized for 2-3 cm, a piece of sero-muscular layer at the posterior gastric wall was excised and then a sero-muscular depth purse-suturing with 3-0 prolene was pre-placed (outer purse-string).
  • Incising anterior gastric wall or opening part of the closed distal gastric stump, the mucosa layer at the sero-muscular defect was incised and then purse-suture at the mucosal tube was pre-placed (inner purse-string).
  • Through the two pre-placed purse-strings, the pancreas remnant was pulled into the gastric lumen and then posterior gastric wall was pushed backward to keep it closely in contact with the retro-peritoneal wall.
  • Postoperative complications included 1 case of ascites, 2 cases of delayed gastric emptying and 1 case of intra-abdominal bleeding.
  • [MeSH-major] Anastomosis, Surgical / methods. Pancreas / surgery. Stomach / surgery

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  • (PMID = 20193541.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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20. Hirasaki S, Kanzaki H, Fujita K, Matsumura S, Matsumoto E, Yumoto E, Suzuki S: Papillary adenocarcinoma occurring in a gastric hyperplastic polyp observed by magnifying endoscopy and treated with endoscopic mucosal resection. Intern Med; 2008;47(10):949-52
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  • [Title] Papillary adenocarcinoma occurring in a gastric hyperplastic polyp observed by magnifying endoscopy and treated with endoscopic mucosal resection.
  • He had been diagnosed with gastric hyperplastic polyp 4 years previously.
  • Histological examination revealed that a part of the polyp surface was replaced with papillary adenocarcinoma.
  • Diagnosis of papillary adenocarcinoma in a hyperplastic polyp with mucosal invasion was made.
  • Magnifying endoscopy was useful for the detection of gastric cancer occurring in the hyperplastic polyp in the present case.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Polyps / pathology. Stomach Neoplasms / pathology

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  • (PMID = 18480580.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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21. Melo Barbosa HP, Martins LC, Dos Santos SE, Demachki S, Assumpção MB, Aragão CD, de Oliveira Corvelo TC: Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population. World J Gastroenterol; 2009 Mar 28;15(12):1465-71
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  • The histopathological parameters in the gastric biopsies of the patients were according to the Sydney classification.
  • RESULTS: A comparison of the frequencies of the different polymorphisms studied among the patients and the control group demonstrated that the allele IL-1RN*2 was more frequent among patients with gastric ulcers and adenocarcinoma.
  • Carriers of the allele IL-RN*2 and those with reactive serology for anti-CagA IgG had a greater risk of developing peptic ulcer and gastric adenocarcinoma, as well as a higher degree of inflammation and neutrophilic activity in the gastric mucosa.
  • CONCLUSION: Our results indicate a positive association between IL-1RN gene polymorphism and infection by positive H pylori CagA strains and the development of gastric ulcers and adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / genetics. Brazil / epidemiology. Culture. Gastric Mucosa / pathology. Gene Frequency. Humans. Inflammation / pathology. Socioeconomic Factors. Stomach Neoplasms / genetics. Stomach Ulcer / genetics

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  • (PMID = 19322919.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Interleukin-1; 0 / Tumor Necrosis Factor-alpha
  • [Other-IDs] NLM/ PMC2665140
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22. Sharma A, Nitharwal RG, Singh B, Dar A, Dasgupta S, Dhar SK: Helicobacter pylori single-stranded DNA binding protein--functional characterization and modulation of H. pylori DnaB helicase activity. FEBS J; 2009 Jan;276(2):519-31
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  • Helicobacter pylori, an important bacterial pathogen, causes gastric ulcer and gastric adenocarcinoma in humans.


23. Azem J, Svennerholm AM, Lundin BS: B cells pulsed with Helicobacter pylori antigen efficiently activate memory CD8+ T cells from H. pylori-infected individuals. Clin Immunol; 2006 Feb-Mar;118(2-3):284-91
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  • Helicobacter pylori infection causes chronic gastritis that may progress to peptic ulcers or gastric adenocarcinoma and thereby cause major world-wide health problems.
  • We further show that the majority of CD8+ T cells in H. pylori-infected gastric mucosa are memory cells, and that memory CD8+ T cells sorted from peripheral blood of H. pylori-infected individuals respond 15-fold more to H. pylori urease compared to memory cells from uninfected subjects.
  • [MeSH-minor] Adult. Cell Proliferation. Cells, Cultured. Gastric Mucosa / immunology. Gastric Mucosa / microbiology. Humans. Middle Aged. Monocytes / immunology

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  • (PMID = 16324887.001).
  • [ISSN] 1521-6616
  • [Journal-full-title] Clinical immunology (Orlando, Fla.)
  • [ISO-abbreviation] Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Bacterial
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24. Chen CY, Hsu JS, Wu DC, Kang WY, Hsieh JS, Jaw TS, Wu MT, Liu GC: Gastric cancer: preoperative local staging with 3D multi-detector row CT--correlation with surgical and histopathologic results. Radiology; 2007 Feb;242(2):472-82
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  • [Title] Gastric cancer: preoperative local staging with 3D multi-detector row CT--correlation with surgical and histopathologic results.
  • PURPOSE: To prospectively evaluate accuracy of multi-detector row computed tomographic (CT) images for preoperative staging of gastric cancer by using surgical and histopathologic results as reference standards.
  • Fifty-five consecutive patients with gastric cancer (38 men, 17 women; age range, 37-84 years; mean age, 63 years) underwent preoperative CT.
  • All received 6 g of gas-producing crystals before unenhanced CT scanning for gastric distention and virtual gastroscopy.
  • Overall accuracy in assessment of tumor invasion of the gastric wall (T stage) was significantly better with MPR images (89% [49 of 55]) than with transverse images (73% [40 of 55]) (P < .01).
  • CONCLUSION: Multi-detector row CT with combined water and air distention can improve the accuracy of preoperative staging of gastric cancer.
  • [MeSH-major] Image Processing, Computer-Assisted / methods. Imaging, Three-Dimensional / methods. Stomach Neoplasms / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radiography. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Contrast Media. Female. Gastroscopy / methods. Humans. Insufflation. Iohexol / analogs & derivatives. Lymphatic Metastasis / radiography. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Pneumoradiography. Preoperative Care. Prospective Studies. Radiographic Image Enhancement / methods. Time Factors. Water

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  • [Copyright] (c) RSNA, 2007.
  • (PMID = 17255419.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 059QF0KO0R / Water; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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25. Siew LC, Huang C, Fleming J: Gastric adenocarcinoma mistakenly diagnosed as an eating disorder: case report. Int J Eat Disord; 2010 Apr;43(3):286-8
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  • [Title] Gastric adenocarcinoma mistakenly diagnosed as an eating disorder: case report.
  • OBJECTIVE: A number of organic conditions may mimic the symptoms of an eating disorder, however, gastric outlet obstruction mimicking anorexia nervosa has rarely been reported.
  • METHOD: We report the case of a 51-year-old female admitted to an eating disorders unit with an initial diagnosis of anorexia nervosa.
  • RESULTS: The patient's upper gastrointestinal symptoms and weight loss were found to be secondary to gastric outlet obstruction from a gastric adenocarcinoma.
  • Coincidental psychosocial stressors and past psychiatric history, among other factors, had confounded the diagnosis.
  • DISCUSSION: Organic causes of weight loss and upper gastrointestinal symptoms need to be fully excluded prior to making the diagnosis of an eating disorder, particularly when there are atypical features in the presentation.
  • [MeSH-major] Adenocarcinoma / diagnosis. Anorexia Nervosa / diagnosis. Diagnostic Errors. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Body Mass Index. Depressive Disorder, Major / diagnosis. Depressive Disorder, Major / psychology. Dyspepsia / etiology. Energy Intake. Female. Gastric Outlet Obstruction / diagnosis. Gastric Outlet Obstruction / psychology. Gastroscopy. Humans. Middle Aged. Thinness / diagnosis. Thinness / psychology. Tomography, X-Ray Computed. Vomiting / etiology. Weight Loss

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  • (PMID = 19365820.001).
  • [ISSN] 1098-108X
  • [Journal-full-title] The International journal of eating disorders
  • [ISO-abbreviation] Int J Eat Disord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Ihn MH, Kim YJ, Kim JJ, Cho JY, Jin SY: A case of thyroid metastasis originating from early gastric cancer. J Korean Med Sci; 2009 Dec;24(6):1230-3
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  • [Title] A case of thyroid metastasis originating from early gastric cancer.
  • We report a rare case of thyroid metastasis from early gastric cancer with lymph node metastasis in a 63-yr old woman.
  • She was diagnosed with metastatic adenocarcinoma one and a half years after distal subtotal gastrectomy, by fine needle aspiration (FNA) using thyroid sonography.
  • Thyroid metastasis from gastric cancer is extremely rare, and this case is particular in that it is the first report of thyroid metastasis from early gastric cancer.
  • [MeSH-major] Adenocarcinoma. Lymphatic Metastasis / pathology. Stomach Neoplasms / pathology. Thyroid Neoplasms / secondary

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  • (PMID = 19949691.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2775883
  • [Keywords] NOTNLM ; Lymph Node Metastasis / Stomach Neoplasms / Thyroid Metastasis
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27. Fahim A, Macleod D: A case report of gastroparesis secondary to acute renal failure. J Ayub Med Coll Abbottabad; 2008 Jan-Mar;20(1):136-7
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  • A 45-year-old female with a background of poorly differentiated ovarian adenocarcinoma treated with bilateral salpingo-oophorectomy presented with one week history of nausea, vomiting and decreased urine output.
  • Abdominal ultrasound showed marked distension of the stomach without any evidence of renal tract obstruction.
  • Patients with chronic renal failure are prone to develop gastroparesis but it is extremely rare to have gastric stasis following acute renal failure.
  • This case also illustrates the importance of aggressive treatment of a reversible but potentially fatal medical condition which could have been easily overlooked in view of patient's poorly differentiated ovarian cancer.
  • [MeSH-minor] Adenocarcinoma / physiopathology. Female. Fluid Therapy. Humans. Middle Aged. Ovarian Neoplasms / physiopathology. Risk Factors

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  • (PMID = 19024208.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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28. Kim SS, Yoo NJ, Jeong EG, Kim MS, Lee SH: Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas. APMIS; 2008 Sep;116(9):779-84
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  • [Title] Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas.
  • Despite the importance of NEDD4-1 in PTEN regulation in cancer cells, expression of NEDD4-1 protein in cancer tissues is unknown.
  • The aim of this study was to analyze NEDD4-1 expression in colorectal and gastric cancer tissues.
  • We investigated NEDD4-1 protein expression in 103 colorectal and 60 gastric carcinoma tissues by immunohistochemistry using a tissue microarray approach.
  • In the cancers, expression of NEDD4-1 was detected in 82 (80%) of the colorectal carcinomas and 45 (75%) of the gastric carcinomas in cytoplasm.
  • By contrast, the normal mucosal cells of both stomach and colon showed no or very weak expression of NEDD4-1.
  • Our data indicate that NEDD4-1 overexpression is a feature of both colorectal and gastric carcinomas.
  • The increased expression of NEDD4-1 in malignant gastric and colorectal cells compared to their normal epithelial cells suggests that NEDD4-1 expression may play a role in colorectal and gastric cancer development.
  • [MeSH-major] Adenocarcinoma / enzymology. Colorectal Neoplasms / enzymology. Stomach Neoplasms / enzymology. Ubiquitin-Protein Ligases / biosynthesis

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  • (PMID = 19024597.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Endosomal Sorting Complexes Required for Transport; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 6.3.2.19 / Nedd4 ubiquitin protein ligases; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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29. Lerwill MF, Young RH: Ovarian metastases of intestinal-type gastric carcinoma: A clinicopathologic study of 4 cases with contrasting features to those of the Krukenberg tumor. Am J Surg Pathol; 2006 Nov;30(11):1382-8
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  • [Title] Ovarian metastases of intestinal-type gastric carcinoma: A clinicopathologic study of 4 cases with contrasting features to those of the Krukenberg tumor.
  • Ovarian metastases of intestinal-type gastric adenocarcinomas are rare, and information on them is very limited compared with that on signet-ring cell carcinomas that result in the Krukenberg tumor.
  • In 3 patients, the ovarian metastases were identified several to 21 months after the diagnosis of the gastric primary, and the tumors were synchronous in the fourth.
  • Although information is limited, our results suggest that metastatic spread to the ovary by intestinal-type gastric adenocarcinoma is usually seen in patients older than those with Krukenberg tumors, with a known history of gastric carcinoma, and with concomitant widespread disease.
  • Involvement of the ovary by intestinal-type gastric carcinoma produces a microscopic picture distinctly different from that of a Krukenberg tumor.
  • [MeSH-major] Adenocarcinoma / secondary. Krukenberg Tumor / pathology. Ovarian Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Intestinal Neoplasms / metabolism. Intestinal Neoplasms / pathology. Middle Aged


30. Atienza MR, Varela JM: [Menton neuropathy as initial symptom of metastatic gastric carcinoma]. Neurologia; 2008 Jan-Feb;23(1):71-2
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  • [Title] [Menton neuropathy as initial symptom of metastatic gastric carcinoma].
  • [Transliterated title] Neuropatía mentoniana como síntoma inicial de carcinoma gástrico metastásico.
  • [MeSH-major] Adenocarcinoma / secondary. Cranial Nerve Diseases / etiology. Stomach Neoplasms. Trigeminal Nerve
  • [MeSH-minor] Aged. Animals. Chin / innervation. Diagnosis, Differential. Female. Humans

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  • (PMID = 18365785.001).
  • [ISSN] 0213-4853
  • [Journal-full-title] Neurología (Barcelona, Spain)
  • [ISO-abbreviation] Neurologia
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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31. Wakata N, Kiyozuka T, Konno S, Nakazora H, Nomoto N, Sugimoto H, Nemoto H: Autoimmune thrombocytopenic purpura, autoimmune hemolytic anemia and gastric cancer appeared in a patient with myasthenia gravis. Intern Med; 2006;45(7):479-81
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  • [Title] Autoimmune thrombocytopenic purpura, autoimmune hemolytic anemia and gastric cancer appeared in a patient with myasthenia gravis.
  • We report a case of myasthenia gravis (MG) associated with autoimmune thrombocytopenic purpura (AITP) and autoimmune hemolytic anemia (AIHA), and after that gastric cancer appeared.
  • Gastrofiberscopy was performed and biopsy specimens revealed signet cell-type adenocarcinoma.
  • [MeSH-major] Anemia, Hemolytic, Autoimmune / complications. Carcinoma, Signet Ring Cell / complications. Myasthenia Gravis / complications. Purpura, Thrombocytopenic, Idiopathic / complications. Stomach Neoplasms / complications


32. Pan S, Yu Q, Bie M, Liu X: [Adhesion and inhibiting adhesion of Helicobacter pylori to SGC-7901 cell in vitro by four Lactobacilli from human]. Wei Sheng Yan Jiu; 2007 Sep;36(5):618-21
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  • OBJECTIVE: To investigate the adherence ability of four Lactobacilli to gastric epithelial cell SGC-7901 and the ability of inhibiting the adherence of Helicobacter pylori to the cells.
  • CONCLUSION: Four Lactobacilli can inhibit the adherence of Helicobacter pylori to gastric epithelial cell SGC-7901 in vitro, and they should be further evaluated in vivo.
  • [MeSH-major] Antibiosis / physiology. Bacterial Adhesion / physiology. Helicobacter pylori / physiology. Lactobacillus / physiology. Stomach Neoplasms / microbiology
  • [MeSH-minor] Adenocarcinoma / microbiology. Adenocarcinoma / pathology. Cell Line, Tumor. Humans

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  • (PMID = 18095579.001).
  • [ISSN] 1000-8020
  • [Journal-full-title] Wei sheng yan jiu = Journal of hygiene research
  • [ISO-abbreviation] Wei Sheng Yan Jiu
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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33. Park S, Yeo M, Jin JH, Lee KM, Kim SS, Choi SY, Hahm KB: Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells. Dig Dis Sci; 2007 Apr;52(4):973-82
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  • [Title] Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells.
  • Meyer) can inhibit Helicobacter pylori-induced mitogen-activated protein kinase (MAPK) signaling with repressing either nuclear factor (NF)-kappaB-DNA binding activity or releases of IL-8 and COX-2 in gastric epithelial cells (Dig Dis Sci 50:1218-1227, 2005).
  • The 5-LOX enzyme activities were measured by thin layer chromatography using (14)C-labeled arachidonic acid (AA) and quantified by reverse phase-high performance liquid chromatography in human gastric adenocarcinoma (AGS) cells cocultured with H pylori (ATCC 43504 strain) with or without pretreatment of RGE.
  • RGE inactivated c-jun phosphorylation and repressed redox-sensitive transcriptional activation, led to reduced expression of IL-8 and 5-LOX mRNA in gastric mucosal cells, of which action was very similar to known LOX inhibitor, 200 mumol of geraniin.
  • RGE could be phytoceutical against H pylori infection-associated gastric inflammation through its LOX-inhibiting actions, inhibitory 5-LOX enzyme activity, and attenuating its expression.
  • [MeSH-major] Arachidonate 5-Lipoxygenase / metabolism. Epithelial Cells / metabolism. Gastric Mucosa / metabolism. Helicobacter Infections / metabolism. Helicobacter pylori. Panax. Plant Extracts / pharmacology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / microbiology. Arachidonic Acid / metabolism. Chromatography, High Pressure Liquid. Chromatography, Thin Layer. Cyclooxygenase 2 / metabolism. Humans. Hydroxyeicosatetraenoic Acids / metabolism. Lipoxygenase Inhibitors. Mitogen-Activated Protein Kinases / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Stomach Neoplasms / metabolism. Stomach Neoplasms / microbiology. Tumor Cells, Cultured

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  • (PMID = 17333352.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hydroxyeicosatetraenoic Acids; 0 / Lipoxygenase Inhibitors; 0 / Plant Extracts; 27YG812J1I / Arachidonic Acid; 467RNW8T91 / 5-hydroxy-6,8,11,14-eicosatetraenoic acid; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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34. González-Moreno S: Peritoneal dissemination: a pending issue in gastric cancer worth exploring. Ann Surg Oncol; 2009 Dec;16(12):3217-8
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  • [Title] Peritoneal dissemination: a pending issue in gastric cancer worth exploring.
  • [MeSH-major] Adenocarcinoma / secondary. Peritoneal Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 19777178.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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35. Sambasivaiah K, Samson S, Ramakrishna, Prasanna V, Shankar AH: Vermian metastasis causing truncal ataxia and hydrocephalus as initial presentation of carcinoma stomach. Trop Gastroenterol; 2008 Apr-Jun;29(2):101-2
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  • [Title] Vermian metastasis causing truncal ataxia and hydrocephalus as initial presentation of carcinoma stomach.
  • The common presentation of carcinoma stomach includes haematemesis, malaena and gastric outlet obstruction.
  • Symptoms due to metastases to the liver and lung as part of the disease progression are usually preceded by the detection of a primary in the stomach.
  • Carcinoma stomach, where the primary is silent, and which presents with truncal ataxia and features of hydrocephalus due to isolated metastatic deposit in the cerebellar vermis is exceptionally rare.
  • [MeSH-major] Adenocarcinoma / secondary. Cerebellar Neoplasms / secondary. Stomach Neoplasms / pathology


36. Park SH, Lee WK, Chung M, Lee Y, Han SH, Bang SM, Cho EK, Shin DB, Lee JH: Paclitaxel versus docetaxel for advanced gastric cancer: a randomized phase II trial in combination with infusional 5-fluorouracil. Anticancer Drugs; 2006 Feb;17(2):225-9
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  • [Title] Paclitaxel versus docetaxel for advanced gastric cancer: a randomized phase II trial in combination with infusional 5-fluorouracil.
  • Taxanes have clearly demonstrated activities against gastric cancer.
  • We compared the combination of paclitaxel plus 5-fluorouracil (5-FU) (PF) with docetaxel plus 5-FU (DF) as first-line chemotherapy in patients with measurable metastatic gastric cancer.
  • Both PF and DF appear to have efficacy against metastatic gastric cancer, with different, but acceptable, safety profiles.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Stomach Neoplasms / drug therapy

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  • (PMID = 16428942.001).
  • [ISSN] 0959-4973
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; P88XT4IS4D / Paclitaxel; U3P01618RT / Fluorouracil
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37. van Heijl M, van Wijngaarden AK, Lagarde SM, Busch OR, van Lanschot JJ, van Berge Henegouwen MI: Intrathoracic manifestations of cervical anastomotic leaks after transhiatal and transthoracic oesophagectomy. Br J Surg; 2010 May;97(5):726-31
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  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Esophageal Neoplasms / surgery. Esophagectomy / methods. Stomach Neoplasms / surgery. Surgical Wound Dehiscence / complications

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  • [Copyright] Copyright 2010 British Journal of Surgery Society Ltd.
  • [CommentIn] Br J Surg. 2010 Nov;97(11):1745; author reply 1745-6 [20890926.001]
  • (PMID = 20235083.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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38. Mikata R, Fukai K, Imazeki F, Arai M, Fujiwara K, Yonemitsu Y, Zhang K, Nabeya Y, Ochiai T, Yokosuka O: BCL2L10 is frequently silenced by promoter hypermethylation in gastric cancer. Oncol Rep; 2010 Jun;23(6):1701-8
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  • [Title] BCL2L10 is frequently silenced by promoter hypermethylation in gastric cancer.
  • In gastric cancer, several tumor suppressor and tumor-related genes are silenced by aberrant methylation.
  • Previously, we demonstrated that BCL2L10, which belongs to the pro-apoptotic Bcl-2 family, was transcriptionally repressed by promoter hypermethylation and that its overexpression caused apoptosis and growth inhibition of gastric cancer cells.
  • In this study, we investigated the methylation status of BCL2L10 and its expression in 21 gastric cancer tissues and corresponding non-neoplastic mucosae along with the methylation status of p16, RUNX3, and hMLH1 genes by using methylation specific PCR.
  • As a result, aberrant methylation of BCL2L10 was detected in 38% of gastric cancer and in 24% of corresponding non-neoplastic mucosae and correlated with low expression of BCL2L10.
  • Methylation of p16, RUNX3, and hMLH1 was found in gastric cancer and in corresponding non-neoplastic mucosae at almost similar frequencies as previous reports.
  • In conclusion, our data suggest that silencing of BCL2L10 by aberrant methylation is a common feature in gastric cancer and its inactivation may be involved in the early steps of gastric carcinogenesis.
  • [MeSH-major] Adenocarcinoma / genetics. DNA Methylation. Promoter Regions, Genetic / genetics. Proto-Oncogene Proteins c-bcl-2 / genetics. Stomach Neoplasms / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Aged. Aged, 80 and over. Core Binding Factor Alpha 3 Subunit / genetics. DNA, Neoplasm / genetics. DNA-Binding Proteins / genetics. Female. Gastric Mucosa / metabolism. Gastric Mucosa / pathology. Gene Silencing. Humans. Male. Middle Aged. Neoplasm Proteins / genetics. Nuclear Proteins / genetics. Polycomb Repressive Complex 2. Prognosis. Transcription Factors / genetics

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  • (PMID = 20428828.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / BCL2-like 10 protein; 0 / Core Binding Factor Alpha 3 Subunit; 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / MLH1 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / P16 protein, human; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Runx3 protein, human; 0 / Transcription Factors; EC 2.1.1.43 / EZH2 protein, human; EC 2.1.1.43 / Polycomb Repressive Complex 2
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39. Wolf R, Orion E, Davidovici B: Acral lentigines: a new paraneoplastic syndrome. Int J Dermatol; 2008 Feb;47(2):168-70
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  • [MeSH-major] Lentigo / etiology. Paraneoplastic Syndromes / diagnosis
  • [MeSH-minor] Adenocarcinoma / complications. Breast Neoplasms / complications. Female. Foot. Hand. Humans. Lymphoma, Large B-Cell, Diffuse / complications. Male. Middle Aged. Neoplasm Recurrence, Local / complications. Stomach Neoplasms / complications

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  • [CommentIn] Int J Dermatol. 2008 Nov;47(11):1217; author reply 1217-8 [19004079.001]
  • (PMID = 18211490.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Koshiol J, Wei WQ, Kreimer AR, Ren JS, Gravitt P, Chen W, Kim E, Abnet CC, Zhang Y, Kamangar F, Lin DM, Wang GQ, Roth MJ, Dong ZW, Taylor PR, Qiao YL, Dawsey SM: The gastric cardia is not a target for human papillomavirus-induced carcinogenesis. Cancer Epidemiol Biomarkers Prev; 2010 Apr;19(4):1137-9
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  • [Title] The gastric cardia is not a target for human papillomavirus-induced carcinogenesis.
  • BACKGROUND: Thousands of people in central Asia die every year from gastric cardia adenocarcinoma (GCA).
  • GCA arises in the transformation zone between the esophagus and the stomach, similar to cervical and oropharyngeal carcinoma, which arise in areas with transformation zone characteristics.
  • The analogous biology of the gastric cardia to the cervix and oropharynx, where human papillomavirus (HPV) is known to cause cancer, raises the possibility that GCA could be a HPV-associated cancer.
  • Given the availability of an effective HPV vaccine and its potential to prevent HPV-associated cancer, we decided to evaluate the prevalence of HPV DNA in GCA.
  • CONCLUSIONS: These results suggest that HPV does not contribute to gastric cardia carcinogenesis in north central China.
  • IMPACT: Because GCA does not seem to be a HPV-associated cancer, prophylactic HPV vaccination is unlikely to affect rates of GCA in China.

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  • (PMID = 20332262.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / CCR NIH HHS / RC / N01RC47702; United States / Intramural NIH HHS / / Z99 CA999999; United States / CCR NIH HHS / RC / N01-RC-47702
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Other-IDs] NLM/ NIHMS179295; NLM/ PMC2852466
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41. Kim SM, Kim R, Ryu JH, Jho EH, Song KJ, Jang SI, Kee SH: Multinuclear giant cell formation is enhanced by down-regulation of Wnt signaling in gastric cancer cell line, AGS. Exp Cell Res; 2005 Aug 1;308(1):18-28
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  • [Title] Multinuclear giant cell formation is enhanced by down-regulation of Wnt signaling in gastric cancer cell line, AGS.
  • AGS cells, which were derived from malignant gastric adenocarcinoma tissue, lack E-cadherin-mediated cell adhesion but have a high level of nuclear beta-catenin, which suggests altered Wnt signal.
  • [MeSH-major] Adenocarcinoma / metabolism. Giant Cells / metabolism. Intercellular Signaling Peptides and Proteins / metabolism. Signal Transduction / physiology. Stomach Neoplasms / metabolism

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  • (PMID = 15878526.001).
  • [ISSN] 0014-4827
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cadherins; 0 / Culture Media, Serum-Free; 0 / Cytoskeletal Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Trans-Activators; 0 / Wnt Proteins; 0 / beta Catenin
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42. Derakhshan MH, Liptrot S, Paul J, Brown IL, Morrison D, McColl KE: Oesophageal and gastric intestinal-type adenocarcinomas show the same male predominance due to a 17 year delayed development in females. Gut; 2009 Jan;58(1):16-23
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  • [Title] Oesophageal and gastric intestinal-type adenocarcinomas show the same male predominance due to a 17 year delayed development in females.
  • BACKGROUND AND AIMS: Upper gastrointestinal adenocarcinomas show an unexplained male predominance that is more apparent in oesophagus than stomach and in intestinal than diffuse histological subtype.
  • METHOD AND MATERIALS: Of 3270 gastric and oesophageal cancers recorded in the West of Scotland Cancer Registry, 1998-2002, 812 were randomly selected for detailed analysis.
  • The Lauren histological subtype of adenocarcinoma was determined by reviewing 1204 original reports and 3241 biopsies.
  • RESULTS: Analysis included 405 non-cardia cancers, 173 cardia cancers and 209 oesophageal adenocarcinomas.
  • The M/F ratios for oesophageal, cardia and non-cardia gastric cancer were 3.5, 2.0 and 1.6, respectively.
  • CONCLUSION: Male predominance of upper gastrointestinal adenocarcinoma is related to the intestinal histological subtype rather than tumour location and is due to marked delayed development of this subtype in females prior to 50-60 years of age.
  • [MeSH-major] Adenocarcinoma / epidemiology. Esophageal Neoplasms / epidemiology. Stomach Neoplasms / epidemiology


43. Giglio P, Weinberg JS, Forman AD, Wolff R, Groves MD: Neoplastic meningitis in patients with adenocarcinoma of the gastrointestinal tract. Cancer; 2005 Jun 1;103(11):2355-62
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  • [Title] Neoplastic meningitis in patients with adenocarcinoma of the gastrointestinal tract.
  • RESULTS: The patient population was composed of patients with gastric adenocarcinoma (n = 8 patients), esophageal adenocarcinoma (n = 7 patients), colon and/or rectal adenocarcinoma (n = 5 patients), and pancreatic adenocarcinoma (n = 1 patient).
  • The median overall survival after the initial diagnosis of adenocarcinoma was 55 weeks (range, 8-884 wks), and the median survival after the diagnosis of NM was 7 weeks (range, 0-64 wks).
  • No factors identified had an impact on outcome, including symptoms, physical findings at diagnosis, imaging characteristics, or cerebrospinal fluid findings.
  • CONCLUSIONS: Patients with NM from GI tract adenocarcinomas universally had poor outcomes.
  • [MeSH-major] Adenocarcinoma / secondary. Gastrointestinal Neoplasms / pathology. Meningeal Neoplasms / secondary

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  • (PMID = 15856426.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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44. Ibáñez Aguirre FJ, Azagra JS, Erro Azcárate ML, Goergen M, Rico Selas P, Moreno Elola-Olaso A, Clemares de Lama M, de Simone P, Echenique Elizondo MM: Laparoscopic gastrectomy for gastric adenocarcinoma. Long-term results. Rev Esp Enferm Dig; 2006 Jul;98(7):491-500
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  • [Title] Laparoscopic gastrectomy for gastric adenocarcinoma. Long-term results.
  • BACKGROUND: The objective of our paper is to report on the long-term results of patients with gastric cancer treated by mini-invasive surgery with "intention-to-treat" laparoscopy.
  • PATIENTS AND METHODS: Between June 1993 and January 2006, 130 patients comprising 94 men and 36 women with gastric adenocarcinoma were prospectively selected by two surgical teams in three hospitals based on a prior agreement (CHU Charleroi, Belgium, Centre Hospitalier de Luxembourg and Zumárraga Hospital, Spain).
  • Patients with adenocarcinoma of the cardia were excluded.
  • CONCLUSIONS: Laparoscopic gastrectomy with any kind of lymphadenectomy is a major but safe operation with acceptable mortality and morbility rates in patients with advanced gastric cancer, usually in poor general condition.
  • [MeSH-major] Adenocarcinoma / surgery. Gastrectomy / methods. Laparoscopy. Stomach Neoplasms / surgery

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  • [CommentIn] Rev Esp Enferm Dig. 2006 Jul;98(7):485-90 [17022697.001]
  • (PMID = 17022698.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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45. Chakrabarti N, Moulick A, Saha J, Dutta A: Splenic metastasis and bleeding manifestations--an unusual association with gastric malignancy. J Assoc Physicians India; 2008 Jul;56:543-4
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  • [Title] Splenic metastasis and bleeding manifestations--an unusual association with gastric malignancy.
  • We report the case of a 30 year old female who presented with purpura and melena and who was later diagnosed to have a mucinous adenocarcinoma of stomach with disseminated intravascular coagulation and splenic metastasis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Disseminated Intravascular Coagulation / etiology. Splenic Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 18846909.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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46. Herrera-Goepfert R, Akiba S, Koriyama C, Ding S, Reyes E, Itoh T, Minakami Y, Eizuru Y: Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population. World J Gastroenterol; 2005 Oct 21;11(39):6096-103
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  • [Title] Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population.
  • AIM: To investigate features of Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) among a Mexican population.
  • METHODS: Cases of primary gastric adenocarcinoma were retrieved from the files of the Departments of Pathology at the Instituto Nacional de Cancerologia and the Instituto Nacional de la Nutricion in Mexico City.
  • The anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer.
  • RESULTS: We studied 330 consecutive, non-selected, primary gastric carcinomas.
  • The mean age for the entire group was 58.1 years (range: 20-88 years), whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years (range: 50-84 years).
  • Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared.
  • EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively.
  • [MeSH-major] Epstein-Barr Virus Infections / complications. Epstein-Barr Virus Infections / ethnology. Stomach Neoplasms / ethnology. Stomach Neoplasms / virology

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  • (PMID = 16273633.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4436624
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47. Enarsson K, Johnsson E, Lindholm C, Lundgren A, Pan-Hammarström Q, Strömberg E, Bergin P, Baunge EL, Svennerholm AM, Quiding-Järbrink M: Differential mechanisms for T lymphocyte recruitment in normal and neoplastic human gastric mucosa. Clin Immunol; 2006 Jan;118(1):24-34
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  • [Title] Differential mechanisms for T lymphocyte recruitment in normal and neoplastic human gastric mucosa.
  • Worldwide, gastric adenocarcinoma (GC) is the second most common cause of death from malignant disease.
  • [MeSH-major] Adenocarcinoma / immunology. Cell Movement / immunology. Gastric Mucosa / immunology. Receptors, Lymphocyte Homing / immunology. Stomach Neoplasms / immunology. T-Lymphocytes / immunology

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  • (PMID = 16157508.001).
  • [ISSN] 1521-6616
  • [Journal-full-title] Clinical immunology (Orlando, Fla.)
  • [ISO-abbreviation] Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / CXCR3 protein, human; 0 / Immunoglobulins; 0 / L-selectin counter-receptors; 0 / LPL binding proteins, human; 0 / MADCAM1 protein, human; 0 / Membrane Proteins; 0 / Mucoproteins; 0 / Receptors, CXCR3; 0 / Receptors, Cell Surface; 0 / Receptors, Chemokine; 0 / Receptors, Lymphocyte Homing
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48. Yang W, Toffa SE, Lohn JW, Seifalian AM, Winslet MC: Malignant ascites increases the antioxidant ability of human ovarian (SKOV-3) and gastric adenocarcinoma (KATO-III) cells. Gynecol Oncol; 2005 Feb;96(2):430-8
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  • [Title] Malignant ascites increases the antioxidant ability of human ovarian (SKOV-3) and gastric adenocarcinoma (KATO-III) cells.
  • OBJECTIVES: The antioxidant status of cancer cells is an important factor in tumor invasion and metastases.
  • This study investigated whether metastatic cancer cells derive beneficial antioxidant protection from ascitic fluid and are rendered resistant to oxidative stress in the form of a chemically generated free radical insult.
  • METHODS: Human gastric carcinoma (KATO-III) and ovarian adenocarcinoma (SKOV-3) cell lines were cultured and incubated for 24 h with (1) M199 medium;.
  • CD44 gene expression of cancer cells was analyzed by Northern blotting.
  • RESULTS: The results showed that the cancer cells were rendered resistant to oxidative stress and with upregulated CD44 gene expression by components of malignant ascites.
  • CONCLUSIONS: These findings suggest that malignant ascites increases the antioxidant ability of cancer cells and the potential of adhesion and invasion.
  • [MeSH-major] Adenocarcinoma / metabolism. Antioxidants / metabolism. Ascites / metabolism. Ovarian Neoplasms / metabolism. Stomach Neoplasms / metabolism


49. Schmidt N, Peitz U, Lippert H, Malfertheiner P: Missing gastric cancer in dyspepsia. Aliment Pharmacol Ther; 2005 Apr 1;21(7):813-20
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  • [Title] Missing gastric cancer in dyspepsia.
  • BACKGROUND: Dyspepsia is common in gastric cancer, but also in many benign conditions.
  • AIM: To investigate whether criteria for endoscopy in patients with dyspepsia are adequate to detect gastric cancer.
  • METHODS: In 215 patients at initial diagnosis of gastric adenocarcinoma, symptoms were classified as alarm and non-alarm.
  • Only 53 potentially curable stages and 18 early gastric cancers occurred, but the tumour stage was not associated with dyspepsia duration, age threshold of 45 years, or alarm symptoms.
  • CONCLUSIONS: Our results support current European Helicobacter Study Group and American Gastroenterological Association criteria for endoscopy in patients with dyspepsia to detect gastric cancer.
  • [MeSH-major] Diagnostic Errors. Dyspepsia / etiology. Gastroscopy / standards. Stomach Neoplasms / diagnosis

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  • (PMID = 15801916.001).
  • [ISSN] 0269-2813
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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50. Kleikamp S, Böhm M, Frosch P, Brinkmeier T: [Acanthosis nigricans, papillomatosis mucosae and "tripe palms" in a patient with metastasized gastric carcinoma]. Dtsch Med Wochenschr; 2006 May 26;131(21):1209-13
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  • [Title] [Acanthosis nigricans, papillomatosis mucosae and "tripe palms" in a patient with metastasized gastric carcinoma].
  • Gastroscopic findings were suspicious of adenocarcinoma of the stomach: it was classified histologically as a signet-ring cell, non-mucinous adenocarcinoma.
  • At the time of diagnosis the tumor had already metastasized to perigastric and peripancreatic lymph nodes with peritoneal carcinosis.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / secondary. Skin Diseases / etiology. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology
  • [MeSH-minor] Acanthosis Nigricans / diagnosis. Acanthosis Nigricans / etiology. Antigens, Tumor-Associated, Carbohydrate / blood. Biomarkers, Tumor / blood. CA-19-9 Antigen / blood. Carcinoembryonic Antigen / blood. Fatal Outcome. Humans. Immunohistochemistry. Keratoderma, Palmoplantar / diagnosis. Keratoderma, Palmoplantar / etiology. Lymphatic Metastasis. Male. Middle Aged. Mouth Neoplasms / diagnosis. Mouth Neoplasms / etiology. Obesity / complications. Papilloma / diagnosis. Papilloma / etiology. Peritoneal Neoplasms / secondary. Receptor, Melanocortin, Type 1 / analysis

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  • (PMID = 16721709.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / CA-72-4 antigen; 0 / Carcinoembryonic Antigen; 0 / Receptor, Melanocortin, Type 1
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51. Akahoshi K, Honda K, Akahane H, Akiba H, Matsui N, Motomura Y, Kubokawa M, Endo S, Higuchi N, Oya M: Endoscopic submucosal dissection by using a grasping-type scissors forceps: a preliminary clinical study (with video). Gastrointest Endosc; 2008 Jun;67(7):1128-33
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  • OBJECTIVE: To evaluate the efficacy and safety of ESD by using GSF for the removal of gastric neoplasms in human beings.
  • PATIENTS: Four patients with early gastric neoplastic lesions.
  • [MeSH-major] Adenocarcinoma / surgery. Gastroscopes. Gastroscopy / methods. Stomach Neoplasms / surgery

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  • (PMID = 18355820.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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52. Hall JD, Kahaleh M, White GE, Talreja J, Northup PG, Shami VM: Presence of lymph node vasculature: a new EUS criterion for benign nodes? Dig Dis Sci; 2009 Jan;54(1):118-21
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  • CONCLUSIONS: The presence of intranodal vasculature was universally associated with a benign diagnosis.
  • [MeSH-minor] Adenocarcinoma / diagnostic imaging. Adenocarcinoma / pathology. Biopsy, Fine-Needle. Esophageal Neoplasms / diagnostic imaging. Esophageal Neoplasms / pathology. Female. Humans. Logistic Models. Male. Mediastinum. Middle Aged. Predictive Value of Tests. Prospective Studies. Risk Factors. Stomach Neoplasms / diagnostic imaging. Stomach Neoplasms / pathology

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  • [CommentIn] Dig Dis Sci. 2009 Aug;54(8):1812-3 [19513832.001]
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  • (PMID = 18473175.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK067629
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Li X, Yue ZC, Zhang YY, Bai J, Meng XN, Geng JS, Fu SB: Elevated serum level and gene polymorphisms of TGF-beta1 in gastric cancer. J Clin Lab Anal; 2008;22(3):164-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Elevated serum level and gene polymorphisms of TGF-beta1 in gastric cancer.
  • In this study, serum TGF-beta1 levels in gastric cancer (GC) patients and healthy volunteers were measured using enzyme-linked immunosorbent assay (ELISA).
  • Our evidence suggested that serum concentration of TGF-beta1 might be a novel tumor marker for GC and the polymorphisms of TGF-beta1 gene did not play a role as a determinant of serum TGF-beta1 concentration or as a genetic risk factor in the gastric carcinogenesis and progression.
  • [MeSH-major] Adenocarcinoma / blood. Genetic Predisposition to Disease. Polymorphism, Single Nucleotide / genetics. Stomach Neoplasms / blood. Transforming Growth Factor beta1 / blood

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18484655.001).
  • [ISSN] 0887-8013
  • [Journal-full-title] Journal of clinical laboratory analysis
  • [ISO-abbreviation] J. Clin. Lab. Anal.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Transforming Growth Factor beta1
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54. Elaraj DM, Ettinghausen SE: Cytological analysis of peritoneal washings: now part of the standard preoperative staging evaluation for patients with resectable gastric cancer? Ann Surg Oncol; 2005 May;12(5):339-41
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  • [Title] Cytological analysis of peritoneal washings: now part of the standard preoperative staging evaluation for patients with resectable gastric cancer?
  • [MeSH-major] Adenocarcinoma / surgery. Peritoneum / cytology. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • [CommentOn] Ann Surg Oncol. 2005 May;12(5):347-53 [15915368.001]
  • (PMID = 15843872.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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55. Velcheti V, Govindan R: Metastatic cancer involving bladder: a review. Can J Urol; 2007 Feb;14(1):3443-8
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  • [Title] Metastatic cancer involving bladder: a review.
  • PURPOSE: Bladder cancer is the fourth most common cancer in men and the ninth most common cancer in women.
  • Bladder is not a common site for metastasis of cancer and often goes undiagnosed in the clinical follow up of cancer patients.
  • We reviewed the literature for published reports on metastatic cancer involving bladder.
  • MATERIALS AND METHODS: We searched MEDLINE, PubMed and OVID from 1953 to June 2005 for published reports on metastatic cancer involving bladder.
  • They key words used were bladder, cancer and metastatic.
  • All relevant articles reporting metastatic cancer to the bladder were reviewed.
  • Of the malignancies arising from distant foci, melanomas appear to be the most common followed by breast and gastric carcinoma.
  • CONCLUSIONS: The definitive diagnosis of metastatic bladder cancers is often difficult, and poses a significant challenge to the physician, pathologist and the radiologist alike.
  • Bladder adenocarcinomas are uncommon and any adenocarcinoma of the bladder should be viewed with a high index of suspicion for a metastatic cancer from a distant focus.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / secondary
  • [MeSH-minor] Breast Neoplasms / pathology. Canada / epidemiology. Colonic Neoplasms / pathology. Humans. Incidence. Rectal Neoplasms / pathology. Skin Neoplasms / pathology. Stomach Neoplasms / pathology. Urinary Bladder / pathology. Urinary Bladder / radiography. Urogenital Neoplasms / pathology

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  • (PMID = 17324324.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 100
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56. Cienfuegos JA, Hernández-Lizoáin JL, Idoate CP, Zozaya G, Bueno A, Sola JJ: A large gastric duplication (choristoma) in an adult mimicking a mucinous cystic tumor of the pancreas. JOP; 2010;11(3):280-2
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  • [Title] A large gastric duplication (choristoma) in an adult mimicking a mucinous cystic tumor of the pancreas.
  • Gastric duplication represents a very rare entity in the adult population.
  • Most of the symptoms are due to the presence of ectopic gastric mucosa (30-35% of cases), gastrointestinal bleeding or perforation or neoplasm formation.
  • We report a case of gastric duplication in an adult mimicking a mucinous cystic neoplasm of the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Choristoma / pathology. Pancreatic Neoplasms / pathology. Stomach. Stomach Diseases / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 20442530.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Italy
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57. Costantini R, De Nicola P, Bianco F, Cotroneo AR, Iezzi R, Di Bartolomeo N, Innocenti P: Tumor vs non-tumor origin of occult and obscure gastrointestinal bleeding requiring hospitalization. Tumori; 2007 Sep-Oct;93(5):461-6
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  • RESULTS: Thirty-five cases of obscure and 27 cases of occult bleeding were examined; all received a definite diagnosis during hospitalization.
  • In the cases with obscure bleeding the diagnosis was inflammatory bowel disease (n = 7), angiodysplasia (5 gastric, 2 duodenal, 2 jejunal, 3 ileal, 4 right colon), small bowel tumors (4 non-Hodgkin lymphomas, 1 leiomyoma, 6 adenocarcinomas), and gastric metaplasia of Meckel's diverticulum (n = 1).
  • Intestinal resections were performed for all small bowel tumors (8 laparotomic, 3 laparoscopic), 5 angiodysplasias, all cases of inflammatory bowel disease and gastric metaplasia of Meckel's diverticulum; arterial embolization was performed for 11 angiodysplasias.
  • In the cases with occult bleeding the diagnosis was sigmoid colon polyps in 6 (treatment, endoscopic polypectomy) and right colon cancer in 21 (treatment, right hemicolectomy).
  • Thanks to modern technology, however, their diagnosis and treatment can nowadays be promptly and successfully achieved.
  • [MeSH-major] Gastrointestinal Hemorrhage / diagnosis. Intestinal Neoplasms / diagnosis. Occult Blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Capsules. Diagnosis, Differential. Endoscopy, Gastrointestinal. Female. Follow-Up Studies. Humans. Intestine, Small / pathology. Male. Middle Aged. Treatment Outcome. Videotape Recording

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  • (PMID = 18038878.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Capsules
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58. Al-Taie OH, Adam P, Kraus MR, Illert B, Scheurlen M: Giant fold gastritis with consecutive gastric carcinoma in a patient with peutz-jeghers syndrome. Z Gastroenterol; 2005 Jul;43(7):653-6
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  • [Title] Giant fold gastritis with consecutive gastric carcinoma in a patient with peutz-jeghers syndrome.
  • We describe the case of a 36-year-old patient with Peutz-Jeghers syndrome and a very unusual gastric morphology resembling giant fold gastritis.
  • Endoscopic ultrasound documented a hyperechoic widening of the gastric mucosa without involvement of the deeper layers.
  • However, despite annual control gastroscopies, an adenocarcinoma developed between the folds and was in an already advanced stage at diagnosis (UICC III).
  • [MeSH-major] Adenocarcinoma / diagnosis. Gastritis, Hypertrophic / diagnosis. Peutz-Jeghers Syndrome / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cell Transformation, Neoplastic / pathology. Endosonography. Gastrectomy. Gastric Mucosa / pathology. Gastric Mucosa / surgery. Gastroscopy. Helicobacter Infections / diagnosis. Helicobacter Infections / pathology. Helicobacter pylori. Humans. Male. Neoplasm Staging. Predictive Value of Tests

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  • (PMID = 16001347.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Germany
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59. Komatsu S, Ichikawa D, Kurioka H, Koide K, Ueshima Y, Shioaki Y, Lee CJ, Mutoh F, Hosokawa Y, Oka T, Yamagishi H: Intra-abdominal desmoid tumor mimicking lymph node recurrence after gastrectomy for gastric cancer. J Gastroenterol Hepatol; 2006 Jul;21(7):1224-6
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  • [Title] Intra-abdominal desmoid tumor mimicking lymph node recurrence after gastrectomy for gastric cancer.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Adenocarcinoma / surgery. Fibromatosis, Aggressive / diagnosis. Gastrectomy. Neoplasm Recurrence, Local / diagnosis. Stomach Neoplasms / surgery
  • [MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16824087.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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60. Stephens MR, Lewis WG, White S, Blackshaw GR, Edwards P, Barry JD, Allison MC: Prognostic significance of alarm symptoms in patients with gastric cancer. Br J Surg; 2005 Jul;92(7):840-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic significance of alarm symptoms in patients with gastric cancer.
  • BACKGROUND: The aim of this study was to determine the incidence and spectrum of alarm symptoms in patients with newly diagnosed gastric cancer, and to examine the relationship between symptoms and outcome.
  • METHODS: Three hundred consecutive patients with gastric adenocarcinoma were studied prospectively.
  • ) 2.04 to 3.66); P < 0.001), overall stage of cancer (HR 1.83 (95 per cent c.i.
  • 1.53 to 2.19); P < 0.001) and persistent vomiting at diagnosis (HR 1.66 (95 per cent c.i.
  • CONCLUSION: Alarm symptoms are absent in a significant minority of patients with gastric cancer at diagnosis; these patients stand a better chance of curative surgery and long-term survival than those with alarm symptoms.
  • [MeSH-major] Adenocarcinoma / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adult. Age of Onset. Aged. Aged, 80 and over. Antacids / therapeutic use. Early Diagnosis. Epidemiologic Methods. Female. Gastrointestinal Hemorrhage / etiology. Gastroscopy / mortality. Humans. Male. Middle Aged. Prognosis. Wales / epidemiology. Weight Loss

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  • [Copyright] Copyright 2005 British Journal of Surgery Society Ltd.
  • [CommentIn] Br J Surg. 2006 Jan;93(1):122 [16370022.001]
  • (PMID = 15892157.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antacids
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61. Hayashi M, Inokuchi M, Takagi Y, Yamada H, Kojima K, Kumagai J, Kawano T, Sugihara K: High expression of HER3 is associated with a decreased survival in gastric cancer. Clin Cancer Res; 2008 Dec 1;14(23):7843-9
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  • [Title] High expression of HER3 is associated with a decreased survival in gastric cancer.
  • BACKGROUND: The role of human epidermal growth factor receptor (HER) 3 and HER4 has been elucidated in gastric cancer.
  • This study investigated the positive correlation between HER1 and HER4 expression and the prognosis of patients with gastric cancers.
  • EXPERIMENTAL DESIGN: Tumor samples were obtained from gastric adenocarcinomas of 134 patients who underwent a gastrectomy from 1999 to 2002.
  • CONCLUSIONS: HER3 overexpression is strongly associated with tumor progression and poor prognosis of patients with gastric cancer.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Receptor, ErbB-3 / biosynthesis. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology


62. Takagi T, Iio A, Nakagawa Y, Naoe T, Tanigawa N, Akao Y: Decreased expression of microRNA-143 and -145 in human gastric cancers. Oncology; 2009;77(1):12-21
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  • [Title] Decreased expression of microRNA-143 and -145 in human gastric cancers.
  • We investigated the role of the miRNAs miR-143 and miR-145 in gastric cancers.
  • METHODS: The expression levels of miR-143 and miR-145 in the samples from 43 patients with gastric cancer were determined by real-time PCR using TaqMan assay.
  • The growth inhibitory effect was estimated by the transfection of human gastric cancer cells with the miRNA.
  • RESULTS: The expression levels of miR-143 and -145 were decreased in most human gastric cancers examined, as previously reported to occur in colon tumors.
  • The transfection of human gastric MKN-1 cells with miR-145 resulted in a greater growth inhibitory effect than that with miR-143, results which were contrary to those in colon cancers.
  • [MeSH-major] Adenocarcinoma / genetics. Gene Expression Regulation, Neoplastic. MicroRNAs / physiology. Stomach Neoplasms / genetics

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19439999.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / MIRN143 microRNA, human; 0 / MIRN145 microRNA, human; 0 / MicroRNAs; 0 / RNA, Messenger; U3P01618RT / Fluorouracil
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63. Stocker G, Ott K, Henningsen N, Becker K, Hapfelmeier A, Lordick F, Hois S, Plaschke S, Höfler H, Keller G: CyclinD1 and interleukin-1 receptor antagonist polymorphisms are associated with prognosis in neoadjuvant-treated gastric carcinoma. Eur J Cancer; 2009 Dec;45(18):3326-35
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  • [Title] CyclinD1 and interleukin-1 receptor antagonist polymorphisms are associated with prognosis in neoadjuvant-treated gastric carcinoma.
  • PURPOSE: We evaluated DNA polymorphisms in genes related to DNA repair, cell-cycle control and tumour microenvironment to determine possible associations with response and survival in neoadjuvant-treated gastric cancer patients.
  • Significantly worse survival rates were noted in patients homozygous for the G-allele as compared to patients with the AG or AA genotypes of the cyclinD1 polymorphism (OS: P(log-rank) = 0.024; PFS: P(log-rank)=0.007) and in patients homozygous for the short allele compared to all other genotypes at the IL-1RN polymorphic locus (OS: P(log-rank) = 0.026; PFS: P(log-rank) = 0.013).
  • The combination of specific cyclinD1 and IL-1RN genotypes showed a particular prognostic relevance and should be considered an independent prognostic marker for neoadjuvant-treated gastric cancer patients.
  • [MeSH-major] Adenocarcinoma / genetics. Cyclin D1 / genetics. Interleukin 1 Receptor Antagonist Protein / genetics. Polymorphism, Single Nucleotide / genetics. Stomach Neoplasms / genetics

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  • (PMID = 19822419.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interleukin 1 Receptor Antagonist Protein; 136601-57-5 / Cyclin D1; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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64. Haddad FS: Secondary adenocarcinomas of the urinary bladder. J Med Liban; 2008 Jan-Mar;56(1):48
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  • [Title] Secondary adenocarcinomas of the urinary bladder.
  • [MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Stomach Neoplasms / pathology. Urinary Bladder Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Urinary Bladder / pathology

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  • [CommentOn] J Med Liban. 2007 Jul-Sep;55(3):162-4 [17966739.001]
  • (PMID = 19534093.001).
  • [ISSN] 0023-9852
  • [Journal-full-title] Le Journal médical libanais. The Lebanese medical journal
  • [ISO-abbreviation] J Med Liban
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Lebanon
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65. Chen CN, Hsieh FJ, Cheng YM, Chang KJ, Lee PH: Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer. J Surg Oncol; 2006 Sep 1;94(3):226-33
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  • [Title] Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer.
  • This study aimed to evaluate the association of clinicopathologic factors, microvessel density, and patient survival with the expression of iNOS and COX-2 in patients with gastric adenocarcinoma.
  • MATERIALS AND METHODS: Seventy-nine specimens, resected from patients with gastric adenocarcinoma, were investigated by immunohistochemical stain against iNOS and COX-2.
  • In patients with gastric cancer that co-expressed iNOS and COX-2, prognosis was significantly poorer than in those that expressed either iNOS or COX-2, or did not express both of them (P = 0.01738).
  • The Cox proportional hazard regression analysis indicated that iNOS expression, vascular invasion, serosal invasion, and microvessel density are independent prognostic factors for patients with gastric cancer.
  • CONCLUSIONS: iNOS and COX-2 expression of gastric cancer are related to tumor angiogenesis, tumor progression, and patient survival in human gastric cancer.
  • [MeSH-major] Adenocarcinoma / enzymology. Cyclooxygenase 2 / biosynthesis. Neovascularization, Pathologic / metabolism. Nitric Oxide Synthase Type II / biosynthesis. Stomach Neoplasms / enzymology

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  • [Copyright] 2006 Wiley-Liss, Inc.
  • [CommentIn] J Surg Oncol. 2007 Mar 1;95(3):271-2 [17219393.001]
  • (PMID = 16900533.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.99.1 / Cyclooxygenase 2
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66. Kanagavel D, Pokataev IA, Fedyanin MY, Tryakin AA, Bazin IS, Narimanov MN, Yakovleva ES, Garin AM, Tjulandin SA: A prognostic model in patients treated for metastatic gastric cancer with second-line chemotherapy. Ann Oncol; 2010 Sep;21(9):1779-85
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  • [Title] A prognostic model in patients treated for metastatic gastric cancer with second-line chemotherapy.
  • BACKGROUND: This retrospective study was carried out to evaluate the prognostic significance of clinical factors in patients treated for metastatic gastric cancer with second-line chemotherapy.

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  • (PMID = 20150573.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; 50SG953SK6 / Mitomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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67. Lee MH, Kim SR, Soh JS, Chung MJ, Lee YC: A solitary gastric metastasis from pulmonary adenocarcinoma: a case report. Thorax; 2010 Jul;65(7):661-2
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  • [Title] A solitary gastric metastasis from pulmonary adenocarcinoma: a case report.
  • [MeSH-major] Adenocarcinoma / secondary. Lung Neoplasms / diagnosis. Stomach Neoplasms / secondary

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  • (PMID = 20627930.001).
  • [ISSN] 1468-3296
  • [Journal-full-title] Thorax
  • [ISO-abbreviation] Thorax
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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68. de Mingo M, Morán A, Sánchez-Pernaute A, Iniesta P, Díez-Valladares L, Pérez-Aguirre E, de Juan C, García-Aranda C, Díaz-López A, García-Botella A, Martín-Antona E, Benito M, Torres A, Balibrea JL: Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma. Hepatogastroenterology; 2007 Jan-Feb;54(73):315-9
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  • [Title] Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma.
  • BACKGROUND/AIMS: The aim of the present work is to clarify the role of metalloproteinase-9 and its inhibitor in the evolution of gastric cancer after surgical resection.
  • METHODOLOGY: We have studied 44 gastric cancer patients submitted to surgery.
  • Metalloproteinase-9 and tissue inhibitor of metalloproteinase concentrations were investigated by means of ELISA in frozen samples of tumoral and normal gastric mucosa.
  • Cancer tissue also expressed higher levels of TIMP-1, 7.25 versus 4.39 ng/mg of protein.
  • CONCLUSIONS: The expression of metalloproteinase-9 or its inhibitor is related to a more aggressive phenotype of gastric cancer.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Matrix Metalloproteinase 9 / metabolism. Stomach Neoplasms / metabolism. Tissue Inhibitor of Metalloproteinase-1 / metabolism
  • [MeSH-minor] Aged. Enzyme-Linked Immunosorbent Assay. Female. Gastric Mucosa / metabolism. Humans. Male. Prognosis. Survival Analysis

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  • (PMID = 17419282.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.35 / Matrix Metalloproteinase 9
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69. Trejo-de la O A, Torres J, Pérez-Rodríguez M, Camorlinga-Ponce M, Luna LF, Abdo-Francis JM, Lazcano E, Maldonado-Bernal C: TLR4 single-nucleotide polymorphisms alter mucosal cytokine and chemokine patterns in Mexican patients with Helicobacter pylori-associated gastroduodenal diseases. Clin Immunol; 2008 Nov;129(2):333-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Helicobacter pylori is associated with peptic ulcer and gastric adenocarcinoma.
  • We aimed to evaluate the association of TLR2/R753Q and TLR4/D299G/T399I SNPs with gastroduodenal diseases; and study the effect of SNPs on cytokine and chemokine expression in the gastric mucosa.
  • TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric cancer, when compared with non-atrophic gastritis.
  • SNPs in TLR4 gene had an association with severe H. pylori-associated disease and with modified pattern of inflammatory cytokines and chemokines in the gastric mucosa.
  • [MeSH-major] Chemokines / analysis. Cytokines / analysis. Duodenal Ulcer / genetics. Gastritis / genetics. Helicobacter Infections / complications. Helicobacter pylori. Polymorphism, Single Nucleotide. Stomach Neoplasms / genetics. Toll-Like Receptor 2 / genetics. Toll-Like Receptor 4 / genetics

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  • (PMID = 18755634.001).
  • [ISSN] 1521-7035
  • [Journal-full-title] Clinical immunology (Orlando, Fla.)
  • [ISO-abbreviation] Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemokines; 0 / Cytokines; 0 / TLR2 protein, human; 0 / TLR4 protein, human; 0 / Toll-Like Receptor 2; 0 / Toll-Like Receptor 4
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70. Jansen EP, Boot H, Dubbelman R, Verheij M, Cats A: Postoperative chemoradiotherapy in gastric cancer--a phase I-II study of radiotherapy with dose escalation of weekly cisplatin and daily capecitabine chemotherapy. Ann Oncol; 2010 Mar;21(3):530-4
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  • [Title] Postoperative chemoradiotherapy in gastric cancer--a phase I-II study of radiotherapy with dose escalation of weekly cisplatin and daily capecitabine chemotherapy.
  • BACKGROUND: Postoperative chemoradiotherapy with concurrent 5-fluorouracil improves gastric cancer outcome.
  • During chemoradiotherapy, seven patients developed 10 items of grade III and one episode of grade IV (mainly hematological) toxicity (National Cancer Institute-Common Toxicity Criteria version 3.0).
  • CONCLUSIONS: This phase I-II study demonstrated that postoperative chemoradiotherapy with weekly cisplatin and daily capecitabine is feasible in gastric cancer at the defined dose level.
  • This schedule is currently being tested as the experimental arm in a phase III multicenter study (CRITICS: chemoradiotherapy after induction chemotherapy in cancer of the stomach; Clinicaltrials.gov NCT 00407186).

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  • (PMID = 19690058.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00407186
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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71. Morishita Y, Kasakura Y, Kobayashi M, Mochizuki F, Yamagata M, Fujii M, Takayama T: Complete cure of metastatic gastric cancer treated with combination chemotherapy using S-1. Hepatogastroenterology; 2005 Nov-Dec;52(66):1933-5
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  • [Title] Complete cure of metastatic gastric cancer treated with combination chemotherapy using S-1.
  • A 65-year-old man had gastric cancer with liver and lung metastases, and received three cycles of FLEP (5-fluorouracil, leucovorin, etoposide, cisplatin) chemotherapy on June, 2001.
  • The primary lesion became scar ulceration and adenocarcinoma tissue was recognized by biopsy pathologically.
  • The clinical trial of S-1 as an adjuvant therapy for patients with advanced gastric cancer, who underwent curative resection, is ongoing in a multicenter study.
  • [MeSH-minor] Administration, Oral. Aged. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Dose-Response Relationship, Drug. Drug Administration Schedule. Epirubicin / administration & dosage. Fluorouracil / administration & dosage. Follow-Up Studies. Gastrectomy / methods. Humans. Leucovorin / administration & dosage. Male. Neoplasm Staging. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery. Treatment Outcome

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  • (PMID = 16334810.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 3Z8479ZZ5X / Epirubicin; EC 1.3.1.2 / Dihydrouracil Dehydrogenase (NADP); Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; FLEP protocol
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72. Wang XP, Wang QX, Ying XP: Correlation between clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human gastric adenocarcinoma. Tohoku J Exp Med; 2007 May;212(1):35-41
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  • [Title] Correlation between clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human gastric adenocarcinoma.
  • Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues.
  • Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of gastric carcinomas but detailed information is still ambiguous.
  • In this study, we investigated the correlation between clinicopathology and expression of HSP72 and gp96 in human gastric carcinoma.
  • The expression of HSP72 and gp96 was studied in 60 human gastric carcinomas with or without metastasis as well as in mucous membrane adjacent to cancers by way of immunohistochemistry.
  • Likewise, gp96 immunoreactivities were detected in 49 cases of gastric carcinoma (81.7%) and in 15 samples of mucous membrane adjacent to cancer (25.0%).
  • The results indicate that there exists a significant correlation between the expression of HSP72 and gp96 and the progression of gastric carcinomas.
  • The high-level expression of HSP72 and gp96 may be used as diagnostic or prognostic markers for gastric carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Gene Expression. Glycoproteins / metabolism. HSP72 Heat-Shock Proteins / metabolism. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Gastric Mucosa / metabolism. Gastric Mucosa / pathology. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 17464101.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / HSP72 Heat-Shock Proteins
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73. Forte A, Leonetti G, Bosco M, Manfredelli S, De Sanctis R, Urbano V, Bezzi M: [The clinical significance of lymph node micrometastases and of concept of sentinel lymph node]. G Chir; 2006 Jun-Jul;27(6-7):277-80
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  • [MeSH-major] Lymph Nodes / pathology. Lymphatic Metastasis / diagnosis
  • [MeSH-minor] Adenocarcinoma / pathology. Aged. Colonic Neoplasms / pathology. Female. Humans. Immunohistochemistry. Lung Neoplasms / pathology. Male. Middle Aged. Neoplasm Staging. Prognosis. Sentinel Lymph Node Biopsy. Stomach Neoplasms / pathology

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  • (PMID = 17062200.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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74. Jhawer M, Coit D, Brennan M, Qin LX, Gonen M, Klimstra D, Tang L, Kelsen DP, Shah MA: Perineural invasion after preoperative chemotherapy predicts poor survival in patients with locally advanced gastric cancer: gene expression analysis with pathologic validation. Am J Clin Oncol; 2009 Aug;32(4):356-62
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  • [Title] Perineural invasion after preoperative chemotherapy predicts poor survival in patients with locally advanced gastric cancer: gene expression analysis with pathologic validation.
  • BACKGROUND: We examined gene expression profiles and clinicopathologic features (tumor location, stage, graded pathologic response, perineural invasion (PNI), Lauren's classification, and survival) of patients with gastric cancer who received preoperative chemotherapy to identify prognostic markers.
  • METHODS: Thirty-eight patients with locally advanced gastric cancer received preoperative chemotherapy on a phase II trial.
  • The close association between PNI and overall survival was identified and validated immunohistochemically in 31 completely resected gastric tumors.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / therapy. Peripheral Nervous System Neoplasms / mortality. Peripheral Nervous System Neoplasms / therapy. Stomach Neoplasms / mortality. Stomach Neoplasms / therapy

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  • (PMID = 19381079.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA56225
  • [Publication-type] Clinical Trial, Phase II; Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Neoplasm; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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75. Birbe R, Palazzo JP, Walters R, Weinberg D, Schulz S, Waldman SA: Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract. Hum Pathol; 2005 Feb;36(2):170-9
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  • [Title] Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract.
  • Gastrointestinal (GI) tumors continue to be major causes of cancer-related mortality, in part, reflecting metastases that escape detection by histopathology.
  • Guanylyl cyclase C (GC-C) is a receptor selectively expressed by intestinal epithelial cells whose persistent expression by colorectal carcinomas and ectopic expression by adenocarcinomas of the upper GI tract suggest its use as a marker for GI malignancies.
  • Guanylyl cyclase C protein was expressed by epithelial cells from the duodenum to the rectum, but not by those in normal esophagus and stomach.
  • Expression was retained in tubular adenomas, inflammatory bowel disease, premalignant lesions, and in primary and metastatic adenocarcinomas from the colon, including metastases to lymph nodes and liver.
  • Moreover, GC-C was ectopically expressed in all cases of dysplasia and adenocarcinomas arising from intestinal metaplasia in esophagus and stomach.
  • Thus, GC-C appears to be an immunohistochemical marker for identifying adenocarcinomas of unknown origin, metastases in patients undergoing staging for GI adenocarcinomas, and intestinal metaplasia, dysplasia, and tumors arising therein in the upper GI tract.
  • [MeSH-major] Adenocarcinoma / enzymology. Gastrointestinal Neoplasms / enzymology. Gastrointestinal Tract / enzymology. Guanylate Cyclase / metabolism. Metaplasia / enzymology. Receptors, Peptide / metabolism

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  • (PMID = 15754294.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA75123; United States / NCI NIH HHS / CA / CA79663; United States / NCI NIH HHS / CA / CA95026; United States / NCI NIH HHS / CA / R01 CA075123-06; United States / NIGMS NIH HHS / GM / R01 GM050290-05
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Receptors, Peptide; EC 4.6.1.2 / Guanylate Cyclase; EC 4.6.1.2 / Receptors, Guanylate Cyclase-Coupled; EC 4.6.1.2 / enterotoxin receptor
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76. Liu T, Zhang G, Chen YH, Chen Y, Liu X, Peng J, Xu MH, Yuan JW: Tissue specific expression of suicide genes delivered by nanoparticles inhibits gastric carcinoma growth. Cancer Biol Ther; 2006 Dec;5(12):1683-90
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  • [Title] Tissue specific expression of suicide genes delivered by nanoparticles inhibits gastric carcinoma growth.
  • Developing an efficient and safe strategy to introduce a therapeutic gene into targeting cells in vivo is a key issue in cancer gene therapy nowadays.
  • Novel non-viral gene carriers, such as nanoparticles, have been shown to be able to deliver DNA into cancer cells efficiently.
  • Developing a targeting system for suicide gene is an attractive strategy in cancer gene therapy.
  • This construct was delivered into SGC7901 gastric cancer cells using calcium phosphate nanoparticles (CPNPs).
  • Immunofluorescence experiments showed that yCDglyTK is only expressed in CEA-positive cancer cells, but not in CEA-negative cells.
  • The expression of yCDglyTK induced cancer cell death following the addition of the prodrug 5-FC, and also elicit "bystander effect" to kill the neighboring cells.
  • Intratumoral injection of CPNP-yCDglyTK complex followed by administration of 5-FC produced marked regression in gastric cancer xenografts.
  • Taken together, our study suggests that the combination of calcium phosphate nanoparticles and suicide gene therapy represents a novel approach for targeting gastric cancer gene therapy.
  • [MeSH-major] Genes, Transgenic, Suicide / genetics. Genetic Therapy. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / prevention & control. Animals. Calcium Phosphates. Cell Division / genetics. Cell Line, Tumor. Cytomegalovirus / genetics. DNA, Neoplasm / genetics. HeLa Cells. Humans. Mice. Mice, Nude. Nanotechnology. Reverse Transcriptase Polymerase Chain Reaction. Transplantation, Heterologous

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  • [CommentIn] Cancer Biol Ther. 2006 Dec;5(12):1691-2 [17224632.001]
  • (PMID = 17224635.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Phosphates; 0 / DNA, Neoplasm
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77. Hirasawa T, Gotoda T, Miyata S, Kato Y, Shimoda T, Taniguchi H, Fujisaki J, Sano T, Yamaguchi T: Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer. Gastric Cancer; 2009;12(3):148-52
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  • [Title] Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer.
  • BACKGROUND: Endoscopic resection (ER) has been accepted as minimally invasive treatment in patients with early gastric cancer (EGC) who have a negligible risk of lymph node metastasis.
  • METHODS: We investigated 3843 patients who had undergone gastrectomy with lymph node dissection for solitary UD-type EGC at the Cancer Institute Hospital, Tokyo, and the National Cancer Center Hospital, Tokyo.
  • [MeSH-major] Adenocarcinoma / surgery. Gastric Mucosa / surgery. Gastroscopy / methods. Stomach Neoplasms / surgery


78. Ryan AM, Rowley SP, Fitzgerald AP, Ravi N, Reynolds JV: Adenocarcinoma of the oesophagus and gastric cardia: male preponderance in association with obesity. Eur J Cancer; 2006 May;42(8):1151-8
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  • [Title] Adenocarcinoma of the oesophagus and gastric cardia: male preponderance in association with obesity.
  • Recent evidence links obesity with the rising incidence of oesophageal adenocarcinoma.
  • In Ireland between 1995 and 2004 the incidence of oesophageal adenocarcinoma increased by 38%, and this coincided with a 67% increase in the prevalence of obesity.
  • In this study, a prospective case-control study was undertaken in 760 patients presenting to a tertiary centre between 1994 and 2004 diagnosed with cancer of the oesophagus, gastric cardia or stomach.
  • Multivariate logistic regression models were used to calculate the odds ratio (OR) of developing either cancer type according to quartiles of body mass index (BMI).
  • Based on pre-illness BMI, 82% of patients who developed adenocarcinoma of the oesophagus were either overweight or obese compared with 59% of the healthy control population (P<0.001).
  • A dose-dependent relationship existed between BMI and oesophageal adenocarcinoma in males.
  • Using common cut-off points for BMI, the OR of adenocarcinoma of the lower oesophagus was 11.3 times higher (95% CI: 3.5-36.4) for individuals with a BMI >30 kg/m2 versus individuals with a BMI <22 kg/m2 (P<0.001 for trend).
  • For adenocarcinoma of the gastric cardia, males in the top quartile of BMI had an OR of 3.5 (95% CI: 1.3-9.4) compared with the lowest quartile (P=0.03 for trend).
  • The odds ratio for adenocarcinoma of the oesophagus, the oesophago-gastric junction and gastric cardia rose significantly with increasing BMI.
  • [MeSH-major] Adenocarcinoma / etiology. Carcinoma, Squamous Cell / etiology. Cardia. Esophageal Neoplasms / etiology. Obesity / complications. Stomach Neoplasms / etiology


79. Ebert MP, Model F, Mooney S, Hale K, Lograsso J, Tonnes-Priddy L, Hoffmann J, Csepregi A, Röcken C, Molnar B, Schulz HU, Malfertheiner P, Lofton-Day C: Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas. Gastroenterology; 2006 Nov;131(5):1418-30
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  • [Title] Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas.
  • BACKGROUND & AIMS: The identification of novel genetic and epigenetic markers indicative of changes in the pathogenesis of colon cancer, along with easier-to-use, more sensitive assay methods, may improve the detection, treatment, and overall prognosis of this malignancy.
  • METHODS: Using methylation-specific arbitrarily primed polymerase chain reaction, a fragment of the Aristaless-like homeobox-4 (ALX4) gene that was highly methylated in colon adenomas and cancer was identified.
  • Methylation of ALX4 was analyzed in colorectal adenomas and cancers, in the liver metastases of patients with colorectal cancer, and in 61 other neoplasias, including gastric, esophageal, and hepatocellular cancer and cholangiocarcinoma.
  • ALX4 methylation was also analyzed in the serum of 30 patients with colon cancer.
  • In addition, ALX4 methylation was frequently observed in adenocarcinomas of the esophagus (12/14), stomach (11/15), and bile ducts (4/5) compared with all other cancers (P < .001).
  • ALX4 gene methylation was also more frequently found in sera of patients with colon cancer compared with noncancer controls (P < .0001).
  • CONCLUSIONS: Apart from colon adenomas and primary and metastatic colorectal cancers, ALX4 is frequently methylated in adenocarcinomas of the gastrointestinal tract.
  • ALX4 gene methylation in sera of patients with cancer may thus serve as a methylation-specific test for colon and other gastrointestinal cancers.
  • [MeSH-major] Adenocarcinoma / genetics. Colorectal Neoplasms / genetics. DNA-Binding Proteins / genetics. Transcription Factors / genetics

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  • (PMID = 17101318.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ALX4 protein, human; 0 / DNA-Binding Proteins; 0 / Transcription Factors
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80. Nakagawa S, Nashimoto A, Yabusaki H: [Neoadjuvant chemotherapy for patients with positive cytology from advanced gastric cancer]. Gan To Kagaku Ryoho; 2006 Nov;33(12):1774-6
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  • [Title] [Neoadjuvant chemotherapy for patients with positive cytology from advanced gastric cancer].
  • Free cancer cells from advanced gastric cancer are associated with a poor prognosis.
  • The aim of this study was to clarify the role of neoadjuvant chemotherapy (NAC) for patients with positive cytology from advanced gastric cancer.
  • Thirty four patients with positive cytology and no macroscopic peritoneal deposits from advanced gastric adenocarcinoma at staging laparoscopy were studied.
  • Eighteen of the 23 patients (78%) in the NAC group revealed no free cancer cells at operation.
  • NAC for patients with positive cytology could lead into no free cancer cells at a high rate, but not to improve their prognoses.
  • [MeSH-major] Adenocarcinoma / drug therapy. Stomach Neoplasms / drug therapy

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  • (PMID = 17212104.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
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81. Cai JC, Liu D, Zhang HP, Zhong S, Xia NS: [Promoter methylation of several tumor suppressor genes in human gastric adenocarcinoma]. Zhonghua Yi Xue Za Zhi; 2007 Apr 10;87(14):978-81
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  • [Title] [Promoter methylation of several tumor suppressor genes in human gastric adenocarcinoma].
  • OBJECTIVE: To study the promoter methylation of several tumor suppressor genes in human gastric foveolar epithelia (GFE) of chronic gastritis, adjacent GFE of gastric adenocarcinoma (GAC) and GAC.
  • METHODS: Methylation specific PCR (MSP) technique was used to examine the promoter methylation of 4 tumor suppressor genes (E-cadherin, hMLH1, APC, and MGMT) in 106 paraffin-embedded specimens of GAC, including tumor tissues and adjacent GFE, and 16 paraffin-embedded specimens of GFE of chronic gastritis.
  • Immunohistochemistry was used to detect the protein expression of E-cadherin (E-CD) in 46 out of the 106 cases of GAC.
  • RESULTS: The promoter methylation rates of tumor suppressor genes in the GAC tissue were 72.6% (77/106), significantly higher than that in the adjacent GFE (44.3%, 47/106) and the GFE of chronic gastritis (12.5%, 2/16, P < 0.01).
  • The promote methylation rate of tumor suppressor genes in the GAC Laurén diffuse type was 80.6% (50/62), significantly higher than that of the GAC of intestinal type (61.4%, 27/44, P < 0.01).
  • The rates of promoter methylation was significantly associated with depth of penetration, pTNM staging and degree of differentiation in GAC (all P < 0.05), but was no significantly associated with age, gender, Ming's classification and local lymph node metastasis (all P > 0.05).
  • The rate of loss of E-CD protein expression or heterogeneously reduction of E-CD protein expression in the specimens of GAC with promoter methylation was 90.9% (20/22), significantly higher than that in the specimens of GAC without promoter methylation (9/24, 37.5%, P < 0.01).
  • CONCLUSION: Promoter methylation of above tumor suppressor genes is seldom found in the GFE of chronic gastritis, frequently found in the adjacent GFE of GAC, but very commonly in GAC.
  • Promoter methylation may be an early event in the carcinogenesis of GAC.
  • [MeSH-major] Adenocarcinoma / genetics. DNA Methylation. Genes, Tumor Suppressor. Promoter Regions, Genetic. Stomach Neoplasms / genetics

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  • (PMID = 17650424.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Cadherins; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
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82. Belair C, Darfeuille F, Staedel C: Helicobacter pylori and gastric cancer: possible role of microRNAs in this intimate relationship. Clin Microbiol Infect; 2009 Sep;15(9):806-12
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  • [Title] Helicobacter pylori and gastric cancer: possible role of microRNAs in this intimate relationship.
  • Chronic infection by Helicobacter pylori is a major risk factor for gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. H. pylori possesses a set of virulence factors, including the CagA effector, which interferes with intracellular signalling pathways and mediates phenotypic alterations, strongly evoking neoplasic transformation.
  • This review considers the possible involvement of some miRNAs, including miR-146, miR-155, miR-21, miR-27a, miR-106-93-25 and miR-221-222 clusters and the miR-200 family in H. pylori-induced infection and gastric cancers.
  • Further exploration of miRNA-mediated gene silencing, taking into account the relationship between host targets and bacterial effectors, will most certainly bring new insights into the control of gene expression in human gastric cells chronically infected by H. pylori.
  • [MeSH-major] Helicobacter Infections / complications. Helicobacter pylori / pathogenicity. MicroRNAs / genetics. Stomach Neoplasms / microbiology

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  • (PMID = 19702585.001).
  • [ISSN] 1469-0691
  • [Journal-full-title] Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • [ISO-abbreviation] Clin. Microbiol. Infect.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / MicroRNAs
  • [Number-of-references] 54
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83. Park DJ, Kong SH, Lee HJ, Kim WH, Yang HK, Lee KU, Choe KJ: Subclassification of pT2 gastric adenocarcinoma according to depth of invasion (pT2a vs pT2b) and lymph node status (pN). Surgery; 2007 Jun;141(6):757-63
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  • [Title] Subclassification of pT2 gastric adenocarcinoma according to depth of invasion (pT2a vs pT2b) and lymph node status (pN).
  • BACKGROUND: We investigated prognostic differences according to nodal status in patients with pT2a and pT2b stage gastric cancers.
  • METHODS: The clinicopathologic outcomes of 1118 patients who underwent curative resection and had 15 or more lymph nodes evaluated for pT2 stage gastric cancers between 1986 and 1996 were reviewed retrospectively.
  • Of the study group, 442 (39.5%) patients had pT2a stage gastric cancers and 676 (60.5%) had pT2b stage gastric cancers.
  • The prognosis of patients with pT2a gastric cancers was significantly better than that of patients with pT2b cancers on any pN stage (P < .001).
  • Multivariate analysis identified age, pT, and pN stages as independent prognostic factors for patients with pT2 gastric cancers.
  • CONCLUSIONS: The subclassification of pT2 gastric cancers into pT2a or pT2b is necessary to demonstrate their different prognoses.
  • We propose that the current stage grouping should be modified to better represent the prognosis for patients with stage pT2 gastric cancers.
  • [MeSH-major] Adenocarcinoma / classification. Adenocarcinoma / pathology. Lymph Nodes / pathology. Stomach Neoplasms / classification. Stomach Neoplasms / pathology

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  • (PMID = 17560252.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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84. Nakamura Y, Tanaka F, Nagahara H, Ieta K, Haraguchi N, Mimori K, Sasaki A, Inoue H, Yanaga K, Mori M: Opa interacting protein 5 (OIP5) is a novel cancer-testis specific gene in gastric cancer. Ann Surg Oncol; 2007 Feb;14(2):885-92
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  • [Title] Opa interacting protein 5 (OIP5) is a novel cancer-testis specific gene in gastric cancer.
  • BACKGROUND: Identification of novel cancer-specific antigens is important for the advancement of immunotherapy.
  • Our aim was to identify cancer-specific genes in gastric cancer.
  • METHODS: Using cDNA microarray analysis, we detected genes overexpressed specifically in gastric cancer cells.
  • We also compared the expression status of OIP5 with that of the other known cancer-testis specific genes.
  • RESULTS: Twenty-two genes were determined to be upregulated in gastric cancer cells.
  • Thus OIP5 may be considered a cancer-testis specific gene.
  • In 58 clinical cases of gastric cancer examined, we found OIP5 gene expression in 27 cases (47%).
  • Thirteen of these 27 cases showed no expression of the known cancer specific genes such as MAGE-1, MAGE-3 or NY-ESO-1.
  • CONCLUSIONS: Using a combination of LMD and microarray, we identified OIP5 as a cancer-testis specific gene.
  • Further expression analysis in a set of clinical cases revealed that OIP5 may be a novel immunotherapy target for patients with gastric cancer.
  • [MeSH-major] Adenocarcinoma / genetics. Antigens, Neoplasm / genetics. Exoribonucleases / genetics. Stomach Neoplasms / genetics

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  • (PMID = 17151793.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carrier Proteins; EC 3.1.- / Exoribonucleases
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85. Kim MS, Oh JE, Eom HS, Yoo NJ, Lee SH: Mutational analysis of UBR5 gene encoding an E3 ubiquitin ligase in common human cancers. Pathology; 2010 Jan;42(1):93-4
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  • [MeSH-major] Adenocarcinoma / genetics. Microsatellite Instability. Neoplasms / genetics. Polymorphism, Single-Stranded Conformational. Ubiquitin-Protein Ligases / genetics
  • [MeSH-minor] Breast Neoplasms / genetics. Breast Neoplasms / pathology. Carcinoma, Hepatocellular / genetics. Carcinoma, Hepatocellular / pathology. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. DNA Mutational Analysis. DNA, Neoplasm / analysis. Female. Humans. Leukemia / genetics. Leukemia / pathology. Liver Neoplasms / genetics. Liver Neoplasms / pathology. Lung Neoplasms / genetics. Lung Neoplasms / pathology. Stomach Neoplasms / genetics. Stomach Neoplasms / pathology

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  • (PMID = 20025491.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 6.3.2.- / UBR5 protein, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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86. Ishikawa M, Kitayama J, Fujii S, Ishigami H, Kaizaki S, Nagawa H: Recurrent intramucosal gastric carcinoma with extensive invasion to duodenal mucosa after endoscopic mucosal resection: a case report. Am Surg; 2005 Apr;71(4):366-8
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  • [Title] Recurrent intramucosal gastric carcinoma with extensive invasion to duodenal mucosa after endoscopic mucosal resection: a case report.
  • The occurrence of early gastric carcinoma with invasion to the duodenum is supposed to be very low, although advanced cancers arising in the antrum can often invade the duodenal area.
  • Generally, malignant invasion of the duodenum is difficult to diagnose preoperatively, as spread of gastric cancer to the duodenum is often infiltrative and invades through the submucosal or subserosal layer.
  • We report an unusual case of an intramucosal gastric carcinoma with extensive duodenal invasion that was preoperatively diagnosed by endoscopy.
  • [MeSH-major] Adenocarcinoma / pathology. Duodenal Neoplasms / pathology. Endoscopy, Gastrointestinal. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Follow-Up Studies. Gastrectomy. Gastric Mucosa / pathology. Humans. Laser Coagulation. Male. Neoplasm Invasiveness. Retrospective Studies

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  • (PMID = 15943416.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Yamashita H, Kitayama J, Ishigami H, Yamada J, Miyato H, Kaisaki S, Nagawa H: Endoscopic instillation of indigo carmine dye with acetic acid enables the visualization of distinct margin of superficial gastric lesion; Usefulness in endoscopic treatment and diagnosis of gastric cancer. Dig Liver Dis; 2007 Apr;39(4):389-91
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  • [Title] Endoscopic instillation of indigo carmine dye with acetic acid enables the visualization of distinct margin of superficial gastric lesion; Usefulness in endoscopic treatment and diagnosis of gastric cancer.
  • [MeSH-major] Acetic Acid. Adenocarcinoma / diagnosis. Coloring Agents. Gastroscopy. Indigo Carmine. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Gastric Mucosa / pathology. Humans. Indicators and Reagents. Sensitivity and Specificity. Stomach / pathology

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  • Hazardous Substances Data Bank. INDIGO .
  • Hazardous Substances Data Bank. ACETIC ACID .
  • Hazardous Substances Data Bank. Indigotindisulfonate sodium .
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  • (PMID = 17306635.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Indicators and Reagents; D3741U8K7L / Indigo Carmine; Q40Q9N063P / Acetic Acid
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88. Gold DV, Stein R, Burton J, Goldenberg DM: Enhanced expression of CD74 in gastrointestinal cancers and benign tissues. Int J Clin Exp Pathol; 2010;4(1):1-12
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  • Colorectal and gastric carcinomas gave similar results with 60% and 86%, respectively, positive for CD74 with an intense, diffuse staining pattern.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Antigens, Differentiation, B-Lymphocyte / metabolism. Digestive System Neoplasms / metabolism. Histocompatibility Antigens Class II / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Humans. Immunohistochemistry. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology. Tissue Array Analysis

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  • (PMID = 21228923.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA096924
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Differentiation, B-Lymphocyte; 0 / Biomarkers, Tumor; 0 / Histocompatibility Antigens Class II; 0 / invariant chain
  • [Other-IDs] NLM/ PMC3016099
  • [Keywords] NOTNLM ; CD74 / colon carcinoma / gastric carcinoma / invariant chain / pancreatic carcinoma
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89. Lima EM, Leal MF, Burbano RR, Khayat AS, Assumpção PP, Bello MJ, Rey JA, Smith MA, Casartelli C: Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer. Braz J Med Biol Res; 2008 Jun;41(6):539-43
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  • [Title] Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer.
  • Gastric cancer is the forth most frequent malignancy and the second most common cause of cancer death worldwide.
  • Many tumor genes are inactivated by DNA methylation in gastric cancer.
  • We evaluated the DNA methylation status of ANAPC1, CDKN2A and TP53 by methylation-specific PCR in 20 diffuse- and 26 intestinal-type gastric cancer samples and 20 normal gastric mucosa in individuals from Northern Brazil.
  • All gastric cancer samples were advanced stage adenocarcinomas.
  • Gastric samples were surgically obtained at the João de Barros Barreto University Hospital, State of Pará, and were stored at -80 degrees C before DNA extraction.
  • Patients had never been submitted to chemotherapy or radiotherapy, nor did they have any other diagnosed cancer.
  • None of the gastric cancer samples presented methylated DNA sequences for ANAPC1 and TP53.
  • CDKN2A methylation was not detected in any normal gastric mucosa; however, the CDKN2A promoter was methylated in 30.4% of gastric cancer samples, with 35% methylation in diffuse-type and 26.9% in intestinal-type cancers.
  • Thus, ANAPC1 and TP53 methylation was probably not implicated in gastric carcinogenesis in our samples.
  • CDKN2A can be implicated in the carcinogenesis process of only a subset of gastric neoplasias.

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  • (PMID = 18622497.001).
  • [ISSN] 1414-431X
  • [Journal-full-title] Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • [ISO-abbreviation] Braz. J. Med. Biol. Res.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / ANAPC1 protein, human; 0 / Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome; EC 6.3.2.19 / Anaphase-Promoting Complex-Cyclosome; EC 6.3.2.19 / Ubiquitin-Protein Ligase Complexes
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90. Alici S, Kaya S, Izmirli M, Tuncer I, Doğan E, Ozbek H, Sayarlioglu H: Analysis of survival factors in patients with advanced-stage gastric adenocarcinoma. Med Sci Monit; 2006 May;12(5):CR221-9
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  • [Title] Analysis of survival factors in patients with advanced-stage gastric adenocarcinoma.
  • BACKGROUND: Prognosis in patients with gastric cancer is determined by the tumor itself, as well as certain patient-related factors.
  • MATERIAL/METHODS: In this study, 138 patients with high-grade gastric adenocarcinoma who were admitted to our hospital between September 1999 and April 2002 were retrospectively evaluated in terms of the effects of clinicopathological parameters and treatment approaches on survival by single and multiple variable analyses.
  • Patients histopathologically diagnosed as having gastric adenocarcinomas with stage IV M0 (without distant organ metastasis) or stage IV M1, (with distant organ metastasis) were included in the study.
  • CONCLUSIONS: No surgical treatment, palliative surgery instead of radical surgery, and BMI below 20 on first admission were determined as poor prognostic factors related to survival in patients with high-grade gastric adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / mortality. Stomach Neoplasms / mortality

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  • (PMID = 16641880.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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91. Gao JS, Wang ZJ, Wei GH, Song WL, Yi BQ, Gao ZG, Zhao B, Liu Z, Li A: Deep venous thrombosis after gastrectomy for gastric carcinoma: a case report. World J Gastroenterol; 2009 Feb 21;15(7):885-7
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  • [Title] Deep venous thrombosis after gastrectomy for gastric carcinoma: a case report.
  • The treatment of gastric carcinoma consists of neoadjuvant chemoradiation, partial gastrectomy, subtotal gastrectomy, total gastrectomy, extended resection, and postoperative chemotherapy.
  • Currently, gastrectomy and extended lymphadenectomy is the optimal choice for late gastric carcinoma.
  • However, deep venous thrombosis (DVT) is an uncommon complication after gastrectomy for gastric carcinoma.
  • We describe a case of a 68-year-old female patient with DVT after gastrectomy for gastric carcinoma.
  • We conclude that correct diagnosis and treatment of DVT are crucial.
  • [MeSH-major] Adenocarcinoma / surgery. Gastrectomy / adverse effects. Stomach Neoplasms / surgery. Venous Thrombosis / etiology

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  • (PMID = 19230054.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Heparin, Low-Molecular-Weight
  • [Other-IDs] NLM/ PMC2653393
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92. Gladman MA, Mukherjee D: Electronic clinical challenges and images in GI. Chest pain and congestive cardiac failure due to atrial metastasis from an adenocarcinoma of the gastroesophageal junction. Gastroenterology; 2008 May;134(5):e4-6
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  • [Title] Electronic clinical challenges and images in GI. Chest pain and congestive cardiac failure due to atrial metastasis from an adenocarcinoma of the gastroesophageal junction.
  • [MeSH-major] Adenocarcinoma / secondary. Chest Pain / etiology. Esophagogastric Junction. Heart Failure / etiology. Heart Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Biopsy. Cardiac Surgical Procedures / methods. Diagnosis, Differential. Echocardiography. Esophagectomy / methods. Female. Follow-Up Studies. Gastrectomy / methods. Heart Atria. Humans. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18471494.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Nakamura H, Nakai S, Morifuji M, Fujimoto M, Miyamoto K, Yokoyama Y: [Combination of operation, chemotherapy and radiation for AFP producing gastric cancer--a case report]. Gan To Kagaku Ryoho; 2008 Feb;35(2):299-301
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  • [Title] [Combination of operation, chemotherapy and radiation for AFP producing gastric cancer--a case report].
  • We report a case of AFP producing gastric cancer after a combination of operation, chemotherapy and radiation.
  • He was diagnosed as having type 3 advanced gastric cancer with multiple lymph node metastasis, including No. 8p lymph node, by endoscopy and computed tomography.
  • Histopathological study showed moderately differentiated adenocarcinoma, and immunohistochemical study revealed a few AFP-positive tumor cells.
  • [MeSH-major] Stomach Neoplasms / drug therapy. Stomach Neoplasms / radiotherapy. alpha-Fetoproteins / metabolism

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  • (PMID = 18281769.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / AFP protein, human; 0 / alpha-Fetoproteins
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94. Jin L, Yoshida M, Kitagawa Y, Saikawa Y, Takeuchi H, Wada N, Kumai K, Kubota T, Kitajima M: Subclassification of superficial cardia cancer in relation to the endoscopic esophagogastric junction. J Gastroenterol Hepatol; 2008 Dec;23 Suppl 2:S273-7
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  • [Title] Subclassification of superficial cardia cancer in relation to the endoscopic esophagogastric junction.
  • BACKGROUND: The incidence of adenocarcinoma of the gastric cardia has been reported to be increasing, but the endoscopic characteristics of the mucosal background of the tumor remain unclear.
  • The purpose of the present study was to evaluate the relationship between the location of the adenocarcinoma according to the esophagogastric junction (EGJ) and mucosal characteristics.
  • METHODS: Patients with superficial adenocarcinoma of the gastric cardia diagnosed pathologically were enrolled and divided into the above-EGJ group and the below-EGJ group according to tumor location.
  • CONCLUSION: There were significant differences between cancers above or below the EGJ, so classification of adenocarcinoma of the gastric cardia according to location is recommended.
  • [MeSH-major] Adenocarcinoma / pathology. Cardia / pathology. Endoscopy, Gastrointestinal. Esophagogastric Junction. Gastric Mucosa / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Early Detection of Cancer. Esophagitis, Peptic / pathology. Gastritis, Atrophic / pathology. Hernia, Hiatal / pathology. Humans. Retrospective Studies

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  • (PMID = 19120911.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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95. Shutoh M, Oue N, Aung PP, Noguchi T, Kuraoka K, Nakayama H, Kawahara K, Yasui W: DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation. Cancer; 2005 Oct 15;104(8):1609-19
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  • [Title] DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation.
  • To the authors' knowledge, little is known regarding the involvement of these three genes in gastric carcinoma (GC).
  • None of the 10 normal gastric mucosa samples from young, healthy individuals demonstrated hypermethylation of any of these genes.
  • CONCLUSIONS: The results suggested that gastric carcinogenesis involves transcriptional inactivation by aberrant DNA methylation of genes related to retinoid signaling.
  • [MeSH-major] DNA Methylation. Gene Expression Regulation, Neoplastic. Membrane Proteins / genetics. Receptors, Retinoic Acid / genetics. Retinoids / pharmacology. Retinol-Binding Proteins / genetics. Stomach Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Azacitidine / pharmacology. Carcinoma, Adenosquamous / genetics. Carcinoma, Adenosquamous / pathology. Female. Gastric Mucosa / metabolism. Gastric Mucosa / pathology. Gene Silencing. Genes, Tumor Suppressor. Humans. Intestinal Neoplasms / genetics. Intestinal Neoplasms / pathology. Male. Metaplasia / genetics. Metaplasia / pathology. Middle Aged. Promoter Regions, Genetic / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism. Retinol-Binding Proteins, Cellular. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Transcription, Genetic. Tumor Cells, Cultured

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  • [Copyright] Copyright 2005 American Cancer Society
  • (PMID = 16134180.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / RARRES1 protein, human; 0 / RBP1 protein, human; 0 / RNA, Messenger; 0 / Receptors, Retinoic Acid; 0 / Retinoids; 0 / Retinol-Binding Proteins; 0 / Retinol-Binding Proteins, Cellular; 0 / retinoic acid receptor beta; M801H13NRU / Azacitidine
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96. Yonemura Y, Wu CC, Fukushima N, Honda I, Bandou E, Kawamura T, Kamata T, Kim BS, Matsuki N, Sawa T, Noh SH, East Asia Surgical Oncology Group: Randomized clinical trial of D2 and extended paraaortic lymphadenectomy in patients with gastric cancer. Int J Clin Oncol; 2008 Apr;13(2):132-7
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  • [Title] Randomized clinical trial of D2 and extended paraaortic lymphadenectomy in patients with gastric cancer.
  • BACKGROUND: The survival of patients with advanced gastric cancer after D2 dissection is still poor.
  • METHODS: Patients enrolled in the study had potentially curable gastric adenocarcinoma at an advanced stage.
  • Seven patients (5.2%) in the D2 and 15 (11.2%) in the D4 group died of causes other than gastric cancer recurrence.
  • CONCLUSION: Prophylactic D4 dissection is not recommended for patients with potentially curable advanced gastric cancer.
  • [MeSH-major] Adenocarcinoma / surgery. Gastrectomy / methods. Lymph Node Excision / methods. Stomach Neoplasms / surgery

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  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
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97. Oh SC, Sur HY, Sung HJ, Choi IK, Park SS, Seo JH, Jeen YT, Chun HJ, Shin SW, Mok YJ, Kim JS, Kim YH: A phase II study of biweekly dose-intensified oral capecitabine plus irinotecan (bXELIRI) for patients with advanced or metastatic gastric cancer. Br J Cancer; 2007 May 21;96(10):1514-9
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  • [Title] A phase II study of biweekly dose-intensified oral capecitabine plus irinotecan (bXELIRI) for patients with advanced or metastatic gastric cancer.
  • A previous study concluded that dose-intensified biweekly capecitabine seems to be more effective at increasing both response rate and progression-free survival time than conventional dose and schedule of capecitabine in colon cancer.
  • We conducted this study to ascertain the efficacy and toxicity of dose-intensified biweekly capecitabine and irinotecan combination chemotherapy in chemotherapy-naïve advanced or metastatic gastric cancer patients.
  • Biweekly dose-intensified capecitabine and irinotecan combination chemotherapy was active for the treatment of advanced or metastatic gastric cancers with a tolerable safety profile.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Deoxycytidine / analogs & derivatives. Fluorouracil / analogs & derivatives. Stomach Neoplasms / drug therapy

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  • (PMID = 17473829.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; 7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; capecitabine-irinotecan combination
  • [Other-IDs] NLM/ PMC2359951
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98. Harikumar R, Kunnel P, Sunilraj R: Dissolution of pharmacobezoar using carbonated beverage. Indian J Gastroenterol; 2008 Nov-Dec;27(6):245-6
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  • Bezoars are concretion of undigested material found in the upper alimentary tract, particularly the stomach.
  • Gastric phamacobezoars can be treated with endoscopic fragmentation or surgery.
  • Gastric lavage with carbonated beverage has been successfully used to treat gastric phytobezoars.
  • Subsequent endoscopy revealed an underlying adenocarcinoma in the stomach.
  • [MeSH-major] Bezoars / therapy. Carbonated Beverages. Gastric Lavage / methods
  • [MeSH-minor] Aged. Gastroscopy. Humans. Male. Stomach

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  • (PMID = 19405260.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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99. Sasaki K, Natsugoe S, Aridome K, Ishigami S, Hokita S, Aikou T: The successfully curative treatment of advanced gastric adenocarcinoma with multiple liver metastases and paraaortic lymph node metastases by salvage operation following the biweekly paclitaxel and S-1 combination chemotherapy: a case report. Hepatogastroenterology; 2007 Dec;54(80):2421-4
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  • [Title] The successfully curative treatment of advanced gastric adenocarcinoma with multiple liver metastases and paraaortic lymph node metastases by salvage operation following the biweekly paclitaxel and S-1 combination chemotherapy: a case report.
  • We report the case of 67-year-old man who was given a diagnosis of advanced gastric adenocarcinoma.
  • Biopsy of the liver was performed and the pathological diagnosis indicated no gastric adenocarcinoma cells.
  • The pathological report showed that the lymph node metastases had completely disappeared with single exception and minute cancerous lesions were identified in the gastric mucosa and submucosa.
  • Salvage surgery following paclitaxel and S-1 chemotherapy may be feasible for patients with advanced gastric cancer and complete regression of distant metastases.
  • Biweekly paclitaxel and S-1 combination chemotherapy has been used safely and its administration may be continued for a long time in an outpatient clinic setting for the treatment of advanced gastric cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / secondary. Salvage Therapy. Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology

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  • (PMID = 18265679.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; P88XT4IS4D / Paclitaxel
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100. Wronski M, Ziarkiewicz-Wroblewska B, Gornicka B, Cebulski W, Slodkowski M, Wasiutynski A, Krasnodebski IW: Synchronous occurrence of gastrointestinal stromal tumors and other primary gastrointestinal neoplasms. World J Gastroenterol; 2006 Sep 7;12(33):5360-2
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  • The synchronous stromal tumors were located in the stomach and were incidentally found during the operation.
  • The coexistent neoplasms were colon adenocarcinoma, gastric cancer (2 cases) and gastric lymphoma.
  • [MeSH-major] Gastrointestinal Neoplasms / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Neoplasms, Second Primary / diagnosis

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  • (PMID = 16981268.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Other-IDs] NLM/ PMC4088205
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