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Items 1 to 45 of about 45
1. Kim CW, Shin US, Yu CS, Kim JC: Clinicopathologic characteristics, surgical treatment and outcomes for splenic flexure colon cancer. Cancer Res Treat; 2010 Jun;42(2):69-76

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic characteristics, surgical treatment and outcomes for splenic flexure colon cancer.
  • PURPOSE: This current study examined the clinicopathologic characteristics of patients with splenic flexure (SF) colon cancer and the association with the surgical outcomes to find the optimal procedure to treat this malady.
  • RESULTS: For the SF colon cancer patients, the proportion of males was higher than that for the right-sided colon patients or the sigmoid-descending junction & sigmoid (SD & S) colon patients (p≤=0.05, respectively) and the age at the time of diagnosis was younger (p≤=0.05).
  • The incidence of mucinous adenocarcinoma for the SF patients was similar to that for the patients with right-sided colon cancer, but it was higher than that for the patients with SD & S colon cancer (11.4% vs. 6.5%, p=0.248 or 2.5%, respectively, p=0.001).

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  • (PMID = 20622960.001).
  • [ISSN] 2005-9256
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2901086
  • [Keywords] NOTNLM ; Colectomy / Colonic neoplasms / Left colic flexure / Splenectomy
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2. Mulchandani MH, Chattopadhyay D, Obafunwa JO, Joypaul VB: Gastrointestinal autonomic nerve tumours--report of a case and review of literature. World J Surg Oncol; 2005 Jul 19;3:46

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CASE PRESENTATION: We report a unique case of rectal schwannoma with associated synchronous adenocarcinoma of the splenic flexure and adenoma of the descending colon.

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  • (PMID = 16026628.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1182401
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3. Pisanu A, Ravarino A, Nieddu R, Uccheddu A: Synchronous isolated splenic metastasis from colon carcinoma and concomitant splenic abscess: a case report and review of the literature. World J Gastroenterol; 2007 Nov 7;13(41):5516-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous isolated splenic metastasis from colon carcinoma and concomitant splenic abscess: a case report and review of the literature.
  • This study aimed to describe a case in which an isolated splenic metastasis was synchronous with the colonic primary and a concomitant splenic abscess was associated.
  • Abdominal CT revealed two low-density areas in the spleen and wall-thickening of the left colonic flexure, which was indistinguishable from the spleen parenchyma.
  • The patient underwent emergency celiotomy, with the presumptive diagnosis of obstructing colon carcinoma of the splenic flexure, and concomitant splenic abscess.
  • Pathological findings were consistent with mucinous colonic carcinoma, synchronous isolated splenic metastasis and concomitant splenic abscess.
  • This paper is also a review of the existing literature on the association between colorectal cancer and splenic metastasis.
  • Only 41 cases of isolated splenic metastasis from colon carcinoma have been reported in the literature.
  • This report is the third described case of synchronous isolated splenic metastasis from colon carcinoma.
  • Only one case with concomitant splenic abscess has been previously reported.
  • When obstructing left-sided colorectal cancer is suspected, careful CT examination can allow early diagnosis of splenic involvement by the tumor.
  • The literature review suggests that there might be a significant improvement in survival following splenectomy for a metachronous isolated splenic metastasis from colon carcinoma.
  • Prognosis for synchronous splenic metastasis seems to be related to the advanced stage of the disease.
  • [MeSH-major] Abscess / complications. Adenocarcinoma, Mucinous / secondary. Colonic Neoplasms / pathology. Splenic Diseases / complications. Splenic Neoplasms / secondary

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  • (PMID = 17907299.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 31
  • [Other-IDs] NLM/ PMC4171290
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4. Inagi E, Shimodan S, Amizuka H, Kigawa S, Shimizu Y, Nagashima K, Tanaka S: Pancreatic cancer initially presenting with a pseudocyst at the splenic flexure. Pathol Int; 2006 Sep;56(9):558-62
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreatic cancer initially presenting with a pseudocyst at the splenic flexure.
  • Surgery was performed on a 44-year-old male patient for an abscess-like cavity situated at the mesenteric side of the colon and extending from the splenic flexure to the descending colon.
  • The cancer was a moderately differentiated ductal adenocarcinoma with wide peripancreatic infiltration.

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  • (PMID = 16930338.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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5. Busić Z, Cupurdija K, Kolovrat M, Cavka V, Cavka M, Patrlj L, Servis D, Kvesić A: Isolated splenic metastasis from colon cancer--case report and literature review. Coll Antropol; 2010 Mar;34 Suppl 1:287-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated splenic metastasis from colon cancer--case report and literature review.
  • Solitary splenic metastases are very rare and sporadic.
  • There are several explanations for this low incidence of splenic metastasis including anatomical, histological and immunological features of the spleen.
  • In this paper we present a case of 70-year-old man with no history of previous diseases who was first operated under the diagnosis of acute abdomen revealing perforated colon tumor of splenic flexure with no metastases at that time.
  • Pathological findings revealed sharply bordered, partially necrotic tumor inside of spleen tissue, spreading to, but not reaching splenic hilum.
  • Histology showed low to medium differentiated adenocarcinoma tissue with desmoplastic stromal reaction.
  • In splenic hilum 4 tumor free lymph nodes were harvested.
  • The latest follow up, a year after diagnosis of metastasis showed no signs of cancer disease.
  • Review of the literature showed that long term survival and prognosis of isolated splenic colorectal metastasis after splenectomy are rather optimistic, although these are the cases of distant metastasis.
  • Due to small number of cases reported in literature, definitive conclusions and/or guidelines for the treatment of isolated splenic metastasis cannot be given, but splenectomy and chemotherapy are preferable in the treatment, promising long term survival at least for metachronous metastasis.
  • [MeSH-major] Colonic Neoplasms / pathology. Splenic Neoplasms / secondary

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  • (PMID = 20402335.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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6. Pappas-Gogos G, Karfis EA, Kakadellis J, Tsimoyiannis EC: Intrathoracic cancer of the splenic flexure. Hernia; 2007 Jun;11(3):257-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrathoracic cancer of the splenic flexure.
  • It occurs in 1-5% of polytrauma patients and requires a high degree of suspicion for a rapid diagnosis.
  • The frequency of delayed diagnosis is difficult to be estimated and up to 30% of blunt diaphragmatic ruptures present late.
  • A case of herniated splenic colic flexure through a defect in the left hemidiaphragm and the subsequent development of colon cancer in this area are presented.
  • We emphasize the importance of making a prompt diagnosis in order to avoid further morbidity and mortality in this rare clinical entity.
  • [MeSH-major] Adenocarcinoma / etiology. Colon, Transverse. Colonic Neoplasms / etiology. Diaphragm / injuries. Hernia, Diaphragmatic, Traumatic / complications. Multiple Trauma / complications
  • [MeSH-minor] Accidents, Traffic. Aged. Colectomy / methods. Diagnosis, Differential. Disease-Free Survival. Follow-Up Studies. Humans. Male. Neoplasm Staging. Polytetrafluoroethylene. Prosthesis Implantation / instrumentation. Radiography, Abdominal. Rupture. Surgical Mesh. Tomography, X-Ray Computed

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  • (PMID = 17186114.001).
  • [ISSN] 1265-4906
  • [Journal-full-title] Hernia : the journal of hernias and abdominal wall surgery
  • [ISO-abbreviation] Hernia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 9002-84-0 / Polytetrafluoroethylene
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7. Gencosmanoglu R, Aker F, Kir G, Tozun N: Isolated metachronous splenic metastasis from synchronous colon cancer. World J Surg Oncol; 2006;4:42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated metachronous splenic metastasis from synchronous colon cancer.
  • BACKGROUND: Isolated splenic metastases from colorectal cancer are very rare and there are only 13 cases reported in the English literature so far.
  • Most cases are asymptomatic and the diagnosis is usually made by imaging studies during the evaluation of rising CEA level postoperatively.
  • CASE PRESENTATION: A 76-year-old man underwent an extended left hemicolectomy for synchronous colon cancers located at the left flexure and the sigmoid colon.
  • Histological diagnosis confirmed a metastatic adenocarcinoma with no capsule invasion.
  • To the best of our knowledge, this 14th case of isolated splenic metastasis from colorectal carcinoma is also the first reported case of splenic metastasis demonstrated preoperatively by 18FDG PET-CT fusion scanning which revealed its solitary nature as well.
  • CONCLUSION: Isolated splenic metastasis is a rare finding in the follow-up of colorectal cancer patients and long-term survival can be achieved with splenectomy.

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  • (PMID = 16824207.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1526733
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8. Tan KY, Ho KS, Lai JH, Lim JF, Ooi BS, Tang CL, Eu KW: Cutaneous and subcutaneous metastases of adenocarcinoma of the colon and rectum. Ann Acad Med Singapore; 2006 Aug;35(8):585-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous and subcutaneous metastases of adenocarcinoma of the colon and rectum.
  • CLINICAL PICTURE: The first case was a 70-year-old man with T3N2M0 rectal mucinous adenocarcinoma, who developed an inflammatory subcutaneous metastasis at the left scapula 2 years after anterior resection.
  • The second case was a 51-year-old man with T4N2M0 splenic flexure mucinous adenocarcinoma, who developed metastatic disease including a subcutaneous secondary to the back.
  • The third case was a 53-year-old woman who developed vulval recurrence 10 months after abdomino-perineal resection for a low T3N1M0 rectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Neoplasms, Connective Tissue / secondary. Rectal Neoplasms / pathology. Skin Neoplasms / secondary. Subcutaneous Tissue
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / secondary. Aged. Female. Humans. Male. Middle Aged

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  • (PMID = 17006588.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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9. Qian ZY, Miao Y, Dai CC, Xu ZK, Liu XL: [Combined multiple organ resection in 16 patients with adenocarcinoma of the body or tail of the pancreas]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2005 Oct;27(5):572-4
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Combined multiple organ resection in 16 patients with adenocarcinoma of the body or tail of the pancreas].
  • RESULTS: Multiple organ resection was performed in 6 cases of primary pancreatic adenocarcinoma of the body and tail (3 cases of pancreatic cancer, 2 cases of malignant glucagonoma, and 1 case of well-differentiated pancreatic stromal sarcoma) and 10 cases of extrapancreatic malignancy (4 cases of gastric cancer, 2 cases of gastric leiomyosarcoma, 1 case of duodenal cancer, and 3 cases of colon cancer of hepatic flexure).
  • In addition, 10 patients received splenic flexure colectomy, 6 patients received distal gastrectomy, 3 patients received left nephrectomy, left colectomy, total gastrectomy, liver lobe resection, left adrenalectomy, and local diaphragma resection, and 2 patients received transverse colectomy, subtotal colectomy, proximal proctectomy, proximal gastrectomy, and duodenectomy.
  • [MeSH-major] Adenocarcinoma / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 16274034.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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10. Iitaka D, Ikoma H, Kawaguchi T, Murayama Y, Komatsu S, Shiozaki A, Kuriu Y, Nakanishi M, Ichikawa D, Fujiwara H, Okamoto K, Ochiai T, Kokuba Y, Sonoyama T, Konishi H, Yoshikawa T, Otsuji E: [A case report--locally advanced pancreatic adenocarcinoma was resected after chemotherapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2358-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case report--locally advanced pancreatic adenocarcinoma was resected after chemotherapy].
  • We performed a pancreatic tail resection along with combined resection of third and fourth portions of the duodenum, transverse colon and splenic flexure, and left adrenal gland.
  • In this case, the treatment was initially started by considering the case as one of duodenal cancer, but the final results of a pathological diagnosis revealed that it was pancreatic cancer.
  • [MeSH-major] Adenocarcinoma / therapy. Pancreatic Neoplasms / therapy

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  • (PMID = 21224572.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Drug Combinations; 0 / Taxoids; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 15H5577CQD / docetaxel; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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11. Hsieh YS, Huang KM, Chen TJ, Chou YH, OuYang CM: Metachronous adenocarcinoma occurring at an esophageal colon graft. J Formos Med Assoc; 2005 Jun;104(6):436-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metachronous adenocarcinoma occurring at an esophageal colon graft.
  • He underwent left hemicolectomy for obstructive colon cancer at the splenic flexure at age 55, followed by resection of the interposed colon graft due to adenocarcinoma at age 57.

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  • (PMID = 16037835.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Singapore
  • [Number-of-references] 26
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12. Kitagawa T, Endo H, Suzuki N, Satou A, Kanno T, Takano Y, Fujiu K, Mori M, Teranishi Y: [Colopleural fistula caused by recurrence of gastric cancer; report of a case]. Kyobu Geka; 2007 Dec;60(13):1208-11
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  • An emergent laparotomy for treatment of mechanical ileus 2 weeks after her admission disclosed a tumor obstructing the splenic flexure of the transverse colon, and a double-barreled colostomy was made.
  • Pathologic examination of the tumors obtained from colon, mesocolon and the parietal peritoneum revealed poorly differentiated adenocarcinoma that was the same as her primary gastric cancer.
  • [MeSH-major] Adenocarcinoma / complications. Colonic Diseases / etiology. Colonic Neoplasms / complications. Colonic Neoplasms / secondary. Fistula / etiology. Intestinal Fistula / etiology. Pleural Diseases / etiology. Stomach Neoplasms / pathology

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  • (PMID = 18078093.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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13. Dronamraju SS, Ramamurthy S, Kelly SB, Hayat M: Role of self-expanding metallic stents in the management of malignant obstruction of the proximal colon. Dis Colon Rectum; 2009 Sep;52(9):1657-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This study was performed to determine the outcomes following stenting for lesions proximal to the splenic flexure.
  • Of these, 16 (16.5%) patients had lesions proximal to the splenic flexure: 8 patients had lesions in the ascending colon and 8 patients had lesions in the transverse colon.
  • CONCLUSIONS: Self-expanding metal stents are safe and effective in the management of malignant large-bowel obstruction proximal to the splenic flexure.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Intestinal Obstruction / pathology. Intestinal Obstruction / surgery. Stents

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  • (PMID = 19690497.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Slam KD, Calkins S, Cason FD: LaPlace's law revisited: cecal perforation as an unusual presentation of pancreatic carcinoma. World J Surg Oncol; 2007;5:14
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  • Postoperatively, however, the patient progressed to large bowel obstruction and upon reexploration, a mass could now be delineated, encompassing the splenic flexure, splenic hilum, and distal pancreas.
  • Histological evaluation determined this was locally invasive pancreatic adenocarcinoma, and therefore the true etiology of the original cecal perforation.
  • [MeSH-major] Adenocarcinoma / secondary. Cecal Neoplasms / secondary. Intestinal Perforation / etiology. Neoplasm Invasiveness / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Aged. Biopsy, Needle. Emergency Service, Hospital. Follow-Up Studies. Humans. Immunohistochemistry. Laparotomy / methods. Male. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed

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  • (PMID = 17274817.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1802866
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15. Stefanidis D, Brown K, Nazario H, Trevino HH, Ferral H, Brady CE 3rd, Gross GW, Postoak DW, Chadhury R, Rousseau DL Jr, Kahlenberg MS: Safety and efficacy of metallic stents in the management of colorectal obstruction. JSLS; 2005 Oct-Dec;9(4):454-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The obstructions were located in the sigmoid colon (11 patients), the rectosigmoid (3), the splenic flexure, the hepatic flexure, and the rectum.
  • Stent patency in obstruction secondary to colonic adenocarcinoma was 100% in our follow-up period (range, 5 to 15 months).

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  • (PMID = 16381366.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Metals
  • [Other-IDs] NLM/ PMC3015633
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16. Stipa F, Bascone B, Cimitan A, Villotti G, Burza A, Site PD, Vitale A, Iacopini G: [Endoscopic-laparoscopic treatment of neoplastic occlusion of the left colon]. Chir Ital; 2006 Mar-Apr;58(2):197-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • One patient underwent a left hemicolectomy; while the other was treated with splenic flexure resection.
  • Histological staging revealed a pT3 pNO pMx G2 and a pT4 pN1 pM1 G2 adenocarcinoma, respectively.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / surgery. Colonic Diseases / etiology. Colonic Diseases / surgery. Colonic Neoplasms / complications. Colonic Neoplasms / surgery. Colonoscopy / methods. Intestinal Obstruction / etiology. Intestinal Obstruction / surgery. Laparoscopy

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  • (PMID = 16734168.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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17. Onorati M, Ambrosio MR, Mourmouras V, Mastrogiulio MG, Rocca BJ: Primary linitis plastica of the right colon. Pathologica; 2009 Apr;101(2):85-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This case is of interest for three reasons: the site of origin in the right colon (80% of cases reported develop distally to the splenic flexure), a biopsy previously taken from the mucosa demonstrated the presence of a signet ring cell carcinoma (endoscopic biopsies do not provide a conclusive diagnosis in the majority of cases reported) and hyaline with sparse amyloid nodules were detected in the extensive, dense fibrous tissue intermingled with tumour cells.
  • [MeSH-minor] Adenocarcinoma / pathology. Aged. Humans. Immunohistochemistry. Male. Neoplasms, Second Primary / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 19886554.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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18. Wong MT, Eu KW: Rise of colorectal cancer in Singapore: an epidemiological review. ANZ J Surg; 2007 Jun;77(6):446-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the same period, more than three quarters (75.6%) of colorectal cancers occurred in the distal colon (including splenic flexure, descending, sigmoid colon and rectum), with the predominant histological subtype being adenocarcinoma (approximately 90%).
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adolescent. Adult. Aged. Aged, 80 and over. Asia, Southeastern / epidemiology. Child. Child, Preschool. Colonic Neoplasms / epidemiology. Female. Humans. Infant. Male. Middle Aged. Registries. Singapore / epidemiology

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  • (PMID = 17501884.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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19. Gervaz P, Bucher P, Neyroud-Caspar I, Soravia C, Morel P: Proximal location of colon cancer is a risk factor for development of metachronous colorectal cancer: a population-based study. Dis Colon Rectum; 2005 Feb;48(2):227-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: This study was undertaken to assess the incidence of 1) metachronous colorectal cancer and 2) subsequent extracolonic cancers, in relation to the location (proximal or distal to the splenic flexure) of the first primary colorectal tumor.
  • METHODS: In this population-based study, a cancer registry database was used to identify patients diagnosed with colorectal adenocarcinoma between 1970 and 1999.
  • RESULTS: A total of 5,006 patients had sporadic adenocarcinoma of the colon or rectum during this period of time, with 1,703 first primary tumors (34 percent) being located proximal to the splenic flexure.
  • Our results confirm that proximal colon cancer is a distinct entity, which justifies the reporting of cases of colon cancer according to their location proximal or distal to the splenic flexure.
  • [MeSH-major] Adenocarcinoma / epidemiology. Colonic Neoplasms / epidemiology. Colorectal Neoplasms / epidemiology. Neoplasms, Second Primary / epidemiology

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  • (PMID = 15711864.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Bini EJ, Green B, Poles MA: Screening colonoscopy for the detection of neoplastic lesions in asymptomatic HIV-infected subjects. Gut; 2009 Aug;58(8):1129-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Advanced neoplasms were defined as adenomas >or=10 mm or any adenoma, regardless of size, with villous histology, high-grade dysplasia, or adenocarcinoma.
  • Among patients with colorectal adenocarcinoma, HIV-infected subjects were significantly younger (52.4 (SD 1.3) vs 60.3 (SD 4.0) years, p = 0.002) and were more likely to have advanced cancers (stage III or IV) than control subjects (60.0% vs 16.7%, p = 0.24).
  • Of HIV-infected subjects with advanced neoplasms proximal to the splenic flexure, distal neoplastic lesions were absent in 88.9% of individuals and these would have been missed by flexible sigmoidoscopy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Colonic Neoplasms / diagnosis. HIV Infections / complications

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  • (PMID = 19293177.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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21. Peedikayil MC, Nair P, Seena SM, Radhakrishnan L, Sadasivan S, Naryanan VA, Balakrishnan V: Colorectal cancer distribution in 220 Indian patients undergoing colonoscopy. Indian J Gastroenterol; 2009 Dec;28(6):212-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of the present study was to describe the anatomical distribution and age at diagnosis of colorectal cancer in India.
  • METHODS: Retrospective descriptive analysis of anatomical distribution, age at diagnosis and demography of 220 cases (149 [67.7%] men) of adenocarcinoma of the colon or rectum diagnosed at colonoscopy over a period of five years.
  • RESULTS: The mean age at diagnosis was 58.4 years (SD 13.3; range 23-85 years).
  • Most of the tumors (n=163, 74%) were located distal to the splenic flexure.
  • CONCLUSIONS: Almost one-third of the colorectal cancers in this series occurred in the seventh decade and were located distal to the splenic flexure.
  • [MeSH-major] Adenocarcinoma / epidemiology. Colonic Neoplasms / epidemiology. Colonoscopy. Rectal Neoplasms / epidemiology

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  • (PMID = 20425641.001).
  • [ISSN] 0975-0711
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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22. Sulzyc-Bielicka V, Domagala P, Majdanik E, Chosia M, Bielicki D, Kladny J, Kaczmarczyk M, Safranow K, Domagala W: Nuclear thymidylate synthase expression in sporadic colorectal cancer depends on the site of the tumor. Virchows Arch; 2009 Jun;454(6):695-702
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  • Colorectal carcinoma (CRC) is a heterogeneous disease with specific epidemiological, pathological, molecular, and clinical characteristics that depend on the location of the tumor relative to the splenic flexure.
  • We examined differences in TS protein expression in nuclei of tumor cells between CRCs located proximal and distal to the splenic flexure.
  • [MeSH-major] Adenocarcinoma / enzymology. Cell Nucleus / enzymology. Colorectal Neoplasms / enzymology. Intestine, Large / enzymology

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  • (PMID = 19444465.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.1.1.45 / Thymidylate Synthase
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23. Sjo OH, Lunde OC, Nygaard K, Sandvik L, Nesbakken A: Tumour location is a prognostic factor for survival in colonic cancer patients. Colorectal Dis; 2008 Jan;10(1):33-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: All patients with adenocarcinoma of the colon diagnosed between 1993 and 2000 were registered prospectively.
  • Tumour location in the transverse colon, splenic flexure and descending colon (OR = 1.8), emergency operation (OR = 1.7), TNM stage (OR = 1.8-2.9), blood transfusion of more than two units (OR = 1.8) and age (OR = 4.0-7.1) were independent negative prognostic factors.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Colectomy / methods. Colonic Neoplasms / mortality. Colonic Neoplasms / surgery. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17672872.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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24. Lachiewicz AM, Wilkinson TM, Groben P, Ollila DW, Thomas NE: Muir-Torre syndrome. Am J Clin Dermatol; 2007;8(5):315-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Immunohistochemical examination of the patient's colonic tumor, located proximal to the splenic flexure, revealed absence of MutL homolog (MLH)-1 protein.
  • Gastrointestinal and genitourinary cancers are the most common internal malignancies, with colorectal cancers often occurring at or proximal to the splenic flexure, contrary to most sporadic colorectal cancers.
  • Evidence indicates that for individuals with or at risk of MTS or HNPCC, colonoscopy every 1-2 years beginning at age 20-25 or 10 years younger than the youngest age at diagnosis in the family can be strongly recommended.
  • [MeSH-major] Adenocarcinoma. Adenocarcinoma, Sebaceous / diagnosis. Colorectal Neoplasms. Sebaceous Gland Neoplasms / diagnosis

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  • (PMID = 17902735.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins
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25. Alencar H, Funovics MA, Figueiredo J, Sawaya H, Weissleder R, Mahmood U: Colonic adenocarcinomas: near-infrared microcatheter imaging of smart probes for early detection--study in mice. Radiology; 2007 Jul;244(1):232-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • One day later, animals were noninvasively examined to the point of the splenic flexure by using microcatheter imaging.
  • [MeSH-major] Adenocarcinoma / diagnosis. Cathepsin B. Colonic Neoplasms / diagnosis. Spectroscopy, Near-Infrared / methods
  • [MeSH-minor] Animals. Catheterization / instrumentation. Colonoscopy. Early Diagnosis. Fiber Optic Technology. Mice. Microscopy, Fluorescence. Prospective Studies. Tumor Cells, Cultured

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  • [Copyright] (c) RSNA, 2007.
  • [CommentIn] Radiology. 2007 Jul;244(1):1-2 [17581890.001]
  • (PMID = 17507718.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Grant] United States / NIBIB NIH HHS / EB / R01 EB001872; United States / NCI NIH HHS / CA / R24 CA92782
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.22.1 / Cathepsin B
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26. Marsden N, Saklani AP, Davies M, Chandrasekaran TV, Khot U, Beynon J: Laparoscopic right hemicolectomy for ileocolic intussusception secondary to caecal neoplasm. Ann R Coll Surg Engl; 2009 Nov;91(8):W7-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a case of ileocolic intussusception extending to the splenic flexure.
  • [MeSH-major] Adenocarcinoma / surgery. Cecal Neoplasms / surgery. Ileal Diseases / surgery. Intussusception / surgery

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  • [Cites] Br J Surg. 2008 Jan;95(1):97-101 [18076019.001]
  • [Cites] J Pediatr Surg. 2008 Jul;43(7):1249-53 [18639677.001]
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  • (PMID = 19909608.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2966248
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27. Kim ST, Lee J, Park SH, Park JO, Lim HY, Kang WK, Kim JY, Kim YH, Chang DK, Rhee PL, Kim DS, Yun H, Cho YB, Kim HC, Yun SH, Chun HK, Lee WY, Park YS: The effect of DNA mismatch repair (MMR) status on oxaliplatin-based first-line chemotherapy as in recurrent or metastatic colon cancer. Med Oncol; 2010 Dec;27(4):1277-85
Hazardous Substances Data Bank. LEUCOVORIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We analyzed 171 patients who had been treated with CAPOX or FOLFOX as first-line combination chemotherapy in recurrent or metastatic colon adenocarcinoma between February 2004 and July 2008.
  • Colon cancers with MMR defect (MSI-H and/or MMR-D) are more commonly located in proximal to the splenic flexure (p=0.03).
  • [MeSH-major] Adenocarcinoma / genetics. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colorectal Neoplasms / genetics. DNA Mismatch Repair / drug effects. Microsatellite Instability / drug effects. Neoplasm Recurrence, Local / genetics

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  • Hazardous Substances Data Bank. CAPECITABINE .
  • Hazardous Substances Data Bank. FLUOROURACIL .
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  • (PMID = 19949897.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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28. Kent AJ, Woolf D, McCue J, Greenfield SM: The use of symptoms to predict colorectal cancer site. Can we reduce the pressure on our endoscopy services? Colorectal Dis; 2010 Feb;12(2):114-8
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • One hundred twenty-six were initially seen in the out-patient department, of whom 38 (29%) were right-sided (proximal to the splenic flexure), and 88 (70%) were left-sided (splenic flexure and beyond).
  • We would recommend that patients with altered bowel habit and/or rectal bleeding, and no other symptoms, risk factors or anaemia, can be investigated with a flexible sigmoidoscopy to confirm or refute a diagnosis of colorectal cancer.
  • [MeSH-major] Adenocarcinoma / pathology. Colonoscopy. Colorectal Neoplasms / pathology. Sigmoidoscopy
  • [MeSH-minor] Anemia / diagnosis. Anemia / etiology. Colon, Ascending / pathology. Constipation / etiology. Diarrhea / etiology. Humans. Risk Factors

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  • [CommentIn] Colorectal Dis. 2010 Aug;12(8):834-5 [20456465.001]
  • (PMID = 19207710.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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29. Caputi Iambrenghi O, Ugenti I, Martines G, Marino F, Francesco Altomare D, Memeo V: Endoscopic management of large colorectal polyps. Int J Colorectal Dis; 2009 Jul;24(7):749-53
MedlinePlus Health Information. consumer health - Endoscopy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Fifteen polyps were located in the rectum, 84 in the sigmoid colon, 11 in the descending colon, four in the splenic flexure, 11 in the transverse colon, 11 in the hepatic flexure, seven in the ascending colon and eight in the cecum.
  • At histology, most of polyps (131) were adenomas (nine with adenocarcinoma in situ).

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  • (PMID = 19259689.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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30. Butte JM, Torres J, Duarte I, Zúñiga A: [Composite tumor of the colon with liver metastases]. Cir Esp; 2007 Aug;82(2):128-30
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A computed tomography (CT) scan showed a tumor at the splenic flexure bowel and 2 hepatic nodules, suggesting metastases.
  • Preoperative biopsies confirmed an adenocarcinoma.
  • Histological analysis showed moderately differentiated tubular adenocarcinoma combined with a poorly differentiated neuroendocrine carcinoma and metastases in 25 of 28 lymph nodes.

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  • (PMID = 17785149.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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31. Kolarík J, Drápela J: [An example of the liver metastases downstaging following chemoport implantation]. Rozhl Chir; 2008 Mar;87(3):145-8; discussion 148
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The case review describes a case of a patient, hospitalized with T3N0M1 carcinoma of the splenic flexure, with multiple metastases in the both liver lobes.
  • [MeSH-major] Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Colorectal Neoplasms / pathology. Infusions, Intra-Arterial. Liver Neoplasms / secondary

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  • (PMID = 18459443.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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32. He JJ: [Meta analysis of 2025 cases with multiple primary colorectal carcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 May;9(3):225-9
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 30.9% of the lesions were located in the rectum, 19.9% in the sigmoid, 9.0% in the descending colon, 5.2% the in splenic flexure, 9.1% in the transverse colon, 6.1% in the hepatic flexure, 11.8% in the ascending colon,and 8.1% in the caecum.
  • Histological type was the same in 60.6% of the cases,and adenocarcinoma accounted for 89.2% and cancerization of adenoma 8.4%.
  • The diagnosis mainly depends on colonoscopy and intra-operative exploration.
  • [MeSH-major] Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / surgery

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  • (PMID = 16721683.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Meta-Analysis
  • [Publication-country] China
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33. Meguid RA, Slidell MB, Wolfgang CL, Chang DC, Ahuja N: Is there a difference in survival between right- versus left-sided colon cancers? Ann Surg Oncol; 2008 Sep;15(9):2388-94

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A retrospective survival analysis was performed using the Surveillance, Epidemiology, and End Results Program (SEER) database between 1988 and 2003 on subjects who underwent surgical resection for the a primary diagnosis of pathologically confirmed invasive colon adenocarcinoma.
  • Cox proportional hazard regression analysis was used to assess long-term survival outcomes comparing right-sided (cecum to transverse colon, excluding appendix) versus left-sided (splenic flexure to sigmoid, excluding rectum) colon cancers.
  • RESULTS: A total of 77,978 subjects were identified with adenocarcinoma of the colon.
  • By Cox proportional hazard regression analysis, controlling for statistically significant confounders, including age, sex, race, marital status, tumor stage, tumor size, histologic grade, number of lymph nodes examined, and year of diagnosis, right-sided colon cancers were associated with a 5% increased mortality risk compared with left-sided colon cancers (hazard ratio, 1.04; 95% confidence interval, 1.02-1.07).

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  • (PMID = 18622647.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK007713-13; United States / NIDDK NIH HHS / DK / T32 DK007713; United States / NIDDK NIH HHS / DK / T32 DK007713-13; United States / NIDDK NIH HHS / DK / T32DK007713
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS280426; NLM/ PMC3072702
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34. Pahlavan PS, Kanthan R: The epidemiology and clinical findings of colorectal cancer in Iran. J Gastrointestin Liver Dis; 2006 Mar;15(1):15-9
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumors were categorized according to their distribution as appendix (n=4), cecum ( n=7), right colon (n=1), hepatic flexure (n=2), transverse colon (n=19), splenic flexure (n=3), left colon (n=6), sigmoid ( n=16), rectum (n=117), rectosigmoid and rectal lesions (n=16), and colorectal lesions without known locations (n=9).
  • Non-mucinous adenocarcinoma (AC) was the most common histological type (n=181, 90%), followed by mucinous AC (n=15), squamous cell carcinoma (n=1), carcinoid (n=1), melanoma (n=1) and signet ring carcinoma (n=1).

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  • (PMID = 16680227.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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35. Yiu R, Qiu H, Lee SH, García-Aguilar J: Mechanisms of microsatellite instability in colorectal cancer patients in different age groups. Dis Colon Rectum; 2005 Nov;48(11):2061-9
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: The proportion of colorectal cancers located proximal to the splenic flexure increases with age.
  • [MeSH-major] Adenocarcinoma / genetics. Colorectal Neoplasms / genetics. Microsatellite Repeats

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  • (PMID = 16374936.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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36. Valdespino-Castillo VE, Ruiz-Jaime A: [Renal cell carcinoma with colon metastases: an infrequent site for metastases]. Cir Cir; 2008 Jul-Aug;76(4):339-42
MedlinePlus Health Information. consumer health - Kidney Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell carcinoma is the most frequent histological type, and 30% of renal carcinomas have metastasized at the time of diagnosis.
  • Nevertheless, he presented with hematochezia and underwent colonoscopy where a splenic flexure tumor was demonstrated.
  • [MeSH-major] Adenocarcinoma, Clear Cell / secondary. Carcinoma, Renal Cell / secondary. Colonic Neoplasms / secondary. Kidney Neoplasms / pathology

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  • (PMID = 18778546.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interferon-alpha
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37. Peravali R, Kandiah K, Surah A, Murria P, Taniere P, Radley S: Retrospective analysis of pre- and peri-operative imaging in confirmed proximal colonic cancers--possible implications for screening flexible sigmoidoscopy. Colorectal Dis; 2009 Feb;11(2):146-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: All confirmed proximal colonic cancers (defined as those proximal to the splenic flexure) were identified from a database of pathology specimens at a single centre between January 1999 and August 2006.
  • [MeSH-major] Adenocarcinoma / diagnosis. Colonic Neoplasms / diagnosis. Mass Screening / methods. Sigmoidoscopy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Female. Humans. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity. Sigmoid Neoplasms / diagnosis

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  • (PMID = 18462247.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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38. Luo DC, Cai Q, Sun MH, Ni YZ, Ni SC, Chen ZJ, Li XY, Tao CW, Zhang XM, Shi DR: Clinicopathological and molecular genetic analysis of HNPCC in China. World J Gastroenterol; 2005 Mar 21;11(11):1673-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Average age at diagnosis of the first CRC was 45.7 years; 40.9% and 28.7% of the CRCs were located proximal to the splenic flexure and in the rectum, respectively.
  • 34.4% and 25% of the CRCs were poor differentiation cancer and mucinous adenocarcinoma, respectively.

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  • (PMID = 15786548.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / MLH1 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
  • [Other-IDs] NLM/ PMC4305952
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39. Kang SB, Park JS, Kim DW, Lee TG: Intraoperative technical difficulty during laparoscopy-assisted surgery as a prognostic factor for colorectal cancer. Dis Colon Rectum; 2010 Oct;53(10):1400-8
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Technical difficulties were encountered more frequently in men compared with women (13.5% vs 6.0%, P = .013), and for cancers located in the mid and low rectum, splenic flexure, and descending colon.
  • [MeSH-major] Adenocarcinoma / surgery. Colorectal Neoplasms / surgery. Intraoperative Complications. Laparoscopy / adverse effects. Neoplasm Recurrence, Local / epidemiology

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  • [CommentIn] Dis Colon Rectum. 2011 Jun;54(6):e204; author reply e204-5 [21552042.001]
  • (PMID = 20847622.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Imperiale TF, Glowinski EA, Lin-Cooper C, Larkin GN, Rogge JD, Ransohoff DF: Five-year risk of colorectal neoplasia after negative screening colonoscopy. N Engl J Med; 2008 Sep 18;359(12):1218-24
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A total of 19 advanced adenomas, of which 10 (52.6%) were distal to the splenic flexure, were found in 16 persons (1.3%).
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenoma / epidemiology. Colonic Polyps / epidemiology. Colonoscopy. Colorectal Neoplasms / epidemiology

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  • COS Scholar Universe. author profiles.
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  • [Copyright] 2008 Massachusetts Medical Society
  • [CommentIn] N Engl J Med. 2008 Dec 11;359(24):2611; author reply 2612 [19090029.001]
  • [CommentIn] N Engl J Med. 2008 Dec 11;359(24):2611; author reply 2612 [19073983.001]
  • [CommentIn] N Engl J Med. 2008 Sep 18;359(12):1285-7 [18799563.001]
  • [CommentIn] N Engl J Med. 2008 Dec 11;359(24):2611-2; author reply 2612 [19090030.001]
  • [ErratumIn] N Engl J Med. 2009 Nov 12;361(20):2004
  • (PMID = 18799558.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K24 DK02756
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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41. Mukai M, Tanaka A, Tajima T, Fukasawa M, Yamagiwa T, Okada K, Sato K, Tobita K, Oida Y, Makuuchi H: Two-port hand-assisted laparoscopic surgery for the 2-stage treatment of a complete bowel obstruction by left colon cancer: a case report. Oncol Rep; 2008 Apr;19(4):875-9
MedlinePlus Health Information. consumer health - Intestinal Obstruction.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • On admission, an enema disclosed a complete obstruction at the splenic flexure of the colon.
  • The histological diagnosis was Type 2 circumferential well-differentiated adenocarcinoma with local peritoneal dissemination.

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  • (PMID = 18357370.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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42. Martinez NP, Kanno DT, Pereira JA, Cardinalli IA, Priolli DG: Beta-catenin and E-cadherin tissue "content" as prognostic markers in left-side colorectal cancer. Cancer Biomark; 2010-2011;8(3):129-35
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIAL AND METHODS: Twenty nine patients with colon adenocarcinoma located distal to the splenic flexure were studied.
  • Diagnosis and histological variables related to adenocarcinoma prognosis were evaluated using hematoxylin-eosin.
  • [MeSH-major] Cadherins / analysis. Colorectal Neoplasms / diagnosis. beta Catenin / analysis

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  • (PMID = 22012768.001).
  • [ISSN] 1875-8592
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Carcinoembryonic Antigen; 0 / beta Catenin
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43. Valenzuela CD, Moore HG, Huang WC, Reich EW, Yee H, Ostrer H, Pachter HL: Three synchronous primary carcinomas in a patient with HNPCC associated with a novel germline mutation in MLH1: Case report. World J Surg Oncol; 2009;7:94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This patient expressed a rare and severe phenotype characterized by three synchronous primary carcinomas: ascending and splenic flexure colon adenocarcinomas, and ureteral carcinoma.
  • Establishment of the diagnosis is the crucial first step in initiating appropriate surveillance for colorectal cancer and other HNPCC-associated tumors in at-risk individuals.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Adenocarcinoma / genetics. Colonic Neoplasms / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Germ-Line Mutation / genetics. Neoplasms, Multiple Primary / genetics. Nuclear Proteins / genetics. Ureteral Neoplasms / genetics

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  • (PMID = 19995443.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DNA Primers; 0 / MLH1 protein, human; 0 / Nuclear Proteins
  • [Other-IDs] NLM/ PMC2795749
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44. Shah PR, Raman S, Barker RJ, Ginwalla RM, Kiberu S, Haray PN: The 'wandering' abdominal lump: intussusception up to splenic flexure of an ileocaecal adenocarcinoma. Hosp Med; 2005 Apr;66(4):248-9
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  • [Title] The 'wandering' abdominal lump: intussusception up to splenic flexure of an ileocaecal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ileal Neoplasms / diagnosis. Intussusception / diagnosis. Splenic Diseases / diagnosis

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  • (PMID = 15889880.001).
  • [ISSN] 1462-3935
  • [Journal-full-title] Hospital medicine (London, England : 1998)
  • [ISO-abbreviation] Hosp Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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45. Koide N, Tsuchie K, Mihara E, Itoh O, Nakajima M, Shibata T: Small early invasive colon cancer near the splenic flexure successfully diagnosed by intraoperative magnifying endoscopy. Dig Dis Sci; 2007 Jun;52(6):1394-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small early invasive colon cancer near the splenic flexure successfully diagnosed by intraoperative magnifying endoscopy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Colon, Transverse / pathology. Colonic Neoplasms / diagnosis

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  • (PMID = 17410464.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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