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[Title] Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation.

Approximately 15% of small intestinal adenocarcinomas show inactivation of DNA-mismatch repair (MMR) and display high-level microsatellite instability (MSI-H).

To investigate the cMSI selection in small intestinal carcinogenesis 56 adenocarcinomas were tested for MSI.

Since little is known about MARCKS expression in the intestine, we analyzed MARCKS protein expression in 31 carcinomas.

In line with cMSI induced functional inactivation of MARCKS, 8 out of 11 MSI-H adenocarcinomas showed regional or complete loss of the protein.

In microsatellite stable (MSS) small bowel adenocarcinoma, loss of MARCKS expression was seen in 2 out of 20 tumors (10%).

In conclusion, we herein present a cMSI profile of MSI-H small intestinal adenocarcinomas identifying MARCKS as a frequent target of mutation.

Loss of MARCKS protein expression suggests a significant role of MARCKS inactivation in the pathogenesis of small intestinal adenocarcinomas.

[MeSH-major] Adenocarcinoma / genetics. Intestinal Neoplasms / genetics. Intestine, Small / pathology. Intracellular Signaling Peptides and Proteins / genetics. Membrane Proteins / genetics. Microsatellite Repeats / genetics

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(PMID = 19852062.001).

[ISSN] 1098-2744

[Journal-full-title] Molecular carcinogenesis

[ISO-abbreviation] Mol. Carcinog.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 125267-21-2 / myristoylated alanine-rich C kinase substrate

   

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Two patients were found to have lead-point intussusceptions and both had small-bowel adenocarcinoma, and 10/14 had severe villous atrophy (subtotal or total).

Among those with established celiac disease, IS was detected early, within 3 years of diagnosis.

Adenocarcinoma needs to be excluded.

[MeSH-minor] Abdominal Pain / epidemiology. Abdominal Pain / pathology. Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adult. Atrophy. Biopsy. Capsule Endoscopy. Chi-Square Distribution. Databases, Factual. Female. Follow-Up Studies. Humans. Incidental Findings. Intestinal Neoplasms / epidemiology. Intestinal Neoplasms / pathology. Male. Middle Aged

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(PMID = 20033844.001).

[ISSN] 1573-2568

[Journal-full-title] Digestive diseases and sciences

[ISO-abbreviation] Dig. Dis. Sci.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Adenocarcinoma of the small bowel at a single Korean institute: management and prognosticators.

PURPOSE: Small bowel adenocarcinoma (SBA) is a rare malignancy with a poor outcome.

CONCLUSIONS: Early diagnosis is crucial to improve outcomes of SBA with respect to increasing resectability.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / therapy

[MeSH-minor] Adult. Aged. Aged, 80 and over. Algorithms. Chemotherapy, Adjuvant / methods. Chemotherapy, Adjuvant / utilization. Digestive System Surgical Procedures / methods. Female. Humans. Intestine, Small / pathology. Korea. Male. Middle Aged. Prognosis. Recurrence. Retrospective Studies. Treatment Outcome. Young Adult

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(PMID = 19760196.001).

[ISSN] 1432-1335

[Journal-full-title] Journal of cancer research and clinical oncology

[ISO-abbreviation] J. Cancer Res. Clin. Oncol.

[Language] eng

[Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

   

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[Title] Complete response of an initially non-surgical adenocarcinoma of the duodenum to chemotherapy with the FOLFOX 4 regimen.

INTRODUCTION: The incidence of adenocarcinoma of the small bowel is very low in comparison with that of colorectal cancer.

No standard chemotherapy is defined for non-surgical adenocarcinoma of the small bowel.

CASE REPORT: We report here the case of a young patient with an initially non-surgical adenocarcinoma of the duodenum treated in a palliative setting with the FOLFOX 4 chemotherapy regimen.

CONCLUSION: The FOLFOX 4 regimen seems to be efficacious for some small-bowel adenocarcinomas and can be expected to lead to downstaging.

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy

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(PMID = 19585173.001).

[ISSN] 1873-4626

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol

   

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[Title] A single-institution experience with 491 cases of small bowel adenocarcinoma.

BACKGROUND: The optimal treatment of small bowel adenocarcinoma is unknown.

METHODS: The records of 491 patients with small bowel adenocarcinoma diagnosis between 1970 and 2005 were reviewed for patient and tumor characteristics, treatment effects, and survival.

RESULTS: The median age at diagnosis was 62 years.

CONCLUSIONS: The prognosis of patients with small bowel adenocarcinoma is poor.

[MeSH-major] Adenocarcinoma / surgery. Intestinal Neoplasms / surgery. Intestine, Small

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[Copyright] Published by Elsevier Inc.

(PMID = 20609724.001).

[ISSN] 1879-1883

[Journal-full-title] American journal of surgery

[ISO-abbreviation] Am. J. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] A rare case of primary small bowel adenocarcinoma with intussusception.

In contrast with the colon tract, the incidence of primary malignancies in the small bowel is very low.

We report the case of a 51-year-old man presenting with jejunal intussusception due to a primary adenocarcinoma.

The patient was referred to our division for bowel obstruction.

Histological examination of the specimen resulted in a diagnosis of a primary adenocarcinoma of the small bowel.

In adult intestinal intussusception, resection without reduction is considered the optimal management if an underlying primary malignancy cannot be excluded.

[MeSH-major] Adenocarcinoma / complications. Intussusception / etiology. Jejunal Diseases / etiology. Jejunal Neoplasms / complications

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(PMID = 20572601.001).

[ISSN] 0300-8916

[Journal-full-title] Tumori

[ISO-abbreviation] Tumori

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] Management of adenocarcinoma of the small intestine.

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(PMID = 19626156.001).

[ISSN] 1934-7820

[Journal-full-title] Gastrointestinal cancer research : GCR

[ISO-abbreviation] Gastrointest Cancer Res

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2713137

   

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[Title] Preoperative diagnosis of jejunal adenocarcinoma--a case report.

We report herein the case of a preoperatively diagnosed small bowel adenocarcinoma.

An US-guided fine (20 gauge) needle aspiration (FNA) cytology of the mass was performed and showed moderately differentiated adenocarcinoma of intestinal origin.

On surgical exploration a jejunal tumor of high consistency was found, located 15 cm distantly from the Treitz ligament, infiltrating up to 2/3 of the bowel circumference and partly obstructing its lumen.

The histological evaluation of the resected material showed highly to moderately differentiated adenocarcinoma with 5 regional lymph node metastases.

The combination of US with Doppler and FNA established preoperatively the malignant small bowel disease.

[MeSH-major] Adenocarcinoma / diagnosis. Jejunal Neoplasms / diagnosis

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(PMID = 18404799.001).

[ISSN] 1107-0625

[Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology

[ISO-abbreviation] J BUON

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Greece

   

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[Title] Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.

PURPOSE: Adenocarcinomas of the small bowel and ampulla of Vater represent rare cancers that have limited data regarding first-line therapy.

We conducted a phase II trial to evaluate the benefit of capecitabine in combination with oxaliplatin (CAPOX) in patients with advanced adenocarcinoma of small bowel or ampullary origin.

CAPOX should be considered a new standard regimen for advanced small bowel and ampullary adenocarcinomas.

[MeSH-major] Adenocarcinoma / drug therapy. Ampulla of Vater / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Common Bile Duct Neoplasms / drug therapy. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology

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(PMID = 19164203.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil

   

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[Title] [Primary adenocarcinoma of jejunum with obscure gastrointestinal bleeding].

[Transliterated title] Adenocarcinoma primitivo del digiuno ad esteriorizzazione con enterorragia.

A case of primary small bowel adenocarcinoma is reported because of the rarity of this malignancy.

[MeSH-major] Adenocarcinoma. Gastrointestinal Hemorrhage / etiology. Jejunal Neoplasms

[MeSH-minor] Capsule Endoscopy. Diagnosis, Differential. Female. Humans. Jejunum / pathology. Middle Aged. Occult Blood. Prognosis

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(PMID = 17147051.001).

[ISSN] 0009-9074

[Journal-full-title] La Clinica terapeutica

[ISO-abbreviation] Clin Ter

[Language] ita

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Italy

   

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[Title] [Primary small bowel adenocarcinoma].

[Transliterated title] Adenocarcinoma primario de intestino delgado.

INTRODUCTION: Primary small bowel adenocarcinoma is an uncommon tumour, with non-specific symptoms that cause a delay in the diagnosis and consequently a worse outcome for the patient.

MATERIAL AND METHOD: We performed a retrospective study of our experience with 17 patients diagnosed with primary small bowel adenocarcinoma, excluding all the cases suggesting secondary involvement of the small bowel from an adenocarcinoma in other locations.

Those with duodenal tumours underwent 4 pancreaticoduodenectomies, 3 gastroenterostomies and 1 diagnostic biopsy; 6 bowel resections with lymphadenectomy, 2 en-bloc resections and 1 by-pass were performed on those with jejuno-ileal tumours.

CONCLUSIONS: Curative treatment consists of small bowel resection.

[MeSH-major] Adenocarcinoma. Duodenal Neoplasms. Ileal Neoplasms. Jejunal Neoplasms

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(PMID = 19344893.001).

[ISSN] 0009-739X

[Journal-full-title] Cirugía española

[ISO-abbreviation] Cir Esp

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Spain

   

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[Title] Is there a role for adjuvant therapy in resected adenocarcinoma of the small intestine.

BACKGROUND: The benefit of adjuvant therapy for resected small bowel adenocarcinoma has not been proven.

We undertook a retrospective analysis to evaluate the benefit of adjuvant therapy in a clearly defined patient population with curatively resected small bowel adenocarcinoma.

MATERIAL AND METHODS: We identified 54 patients with small bowel adenocarcinoma who underwent margin-negative surgical resection and were evaluated after surgery at the University of Texas, M. D.

DISCUSSION: The use of adjuvant therapy for curatively resected small bowel adenocarcinoma was associated with an improvement in DFS.

[MeSH-major] Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / therapy. Intestine, Small

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(PMID = 20397775.001).

[ISSN] 1651-226X

[Journal-full-title] Acta oncologica (Stockholm, Sweden)

[ISO-abbreviation] Acta Oncol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

   

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Unconfirmed partial responses were observed in two patients, one with metastatic small bowel adenocarcinoma and the other with metastatic esophageal cancer.

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(PMID = 16278410.001).

[ISSN] 1078-0432

[Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research

[ISO-abbreviation] Clin. Cancer Res.

[Language] eng

[Grant] United States / NCRR NIH HHS / RR / M01 RR00032

[Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents; 30IQX730WE / Polyethylene Glycols; 581079-18-7 / pegamotecan; XT3Z54Z28A / Camptothecin

   

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[Title] [Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report].

[Transliterated title] Adénocarcinome de l'intestin grêle compliquant une maladie coeliaque de l'adulte: à propos d'un cas.

This small bowel adenocarcinoma is rare and concerns less than 5% of the digestive neoplasias.

We are reporting the case of a 67-years-old woman whose coeliac disease has been complicated 5 years thereafter by a jejunal adenocarcinoma.

[MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Celiac Disease / complications. Incidental Findings. Jejunal Neoplasms / complications. Jejunal Neoplasms / diagnosis

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(PMID = 19777919.001).

[ISSN] 0370-629X

[Journal-full-title] Revue médicale de Liège

[ISO-abbreviation] Rev Med Liege

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Belgium

   

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[Title] [A case of jejunal adenocarcinoma with serum DUPAN-2 elevation].

Ileus with ulcerated jejunal tumor was diagnosed and biopsy revealed adenocarcinoma.

Surgical resection was performed: both tumors were adenocarcinoma, but the ovarian tumor was considered to be metastatic clinically and histologically.

This case shows a possible relation between small bowel adenocarcinoma and DUPAN-2.

[MeSH-major] Adenocarcinoma / diagnosis. Antigens, Neoplasm / blood. Jejunal Neoplasms / diagnosis

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(PMID = 21071898.001).

[ISSN] 0446-6586

[Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

[ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DU-PAN-2 antigen, human

   

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[Title] Prognostic factors in primary adenocarcinoma of the small intestine: 13-year single institution experience.

BACKGROUND: Adenocarcinoma of the small bowel is a relatively rare malignancy as compared to the other malignancies of the gastrointestinal tract.

Nonspecific presentation and infrequent occurrence often leads to a delay in diagnosis and consequent poor prognosis.

METHODS: The medical records of a total of 27 patients treated for adenocarcinoma of the small bowel at Providence Hospital and Medical Centers from year 1990 through 2003 were reviewed retrospectively.

RESULTS: The patients included nine males and eighteen females with a median age at diagnosis of 62 years.

Only 48% of the patients had an accurate preoperative diagnosis while another 33% had a diagnosis suspicious of small bowel malignancy.

[MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Intestinal Neoplasms / mortality. Intestinal Neoplasms / surgery. Intestine, Small / pathology

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[Cites] Cancer. 1999 Dec 15;86(12):2693-706 [10594865.001]

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(PMID = 18237404.001).

[ISSN] 1477-7819

[Journal-full-title] World journal of surgical oncology

[ISO-abbreviation] World J Surg Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2253527

   

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[Title] Risk factors associated with small bowel adenocarcinoma in Crohn's disease: a case-control study.

BACKGROUND AND AIMS: It is well established that Crohn's disease (CD) is associated with an increased risk of small bowel adenocarcinoma (SBA).

METHODS: In 11 French centers affiliated with the GETAID (Groupe d'Etude Thérapeutique des Affections Inflammatoires du Tube Digestif), we identified 29 patients with CD and SBA.

RESULTS: In univariate analysis, the cases had had significantly less small bowel resection and received prolonged treatment with salicylates (more than 2 yr), less often than the controls (odds ratio, OR [95% confidence interval, CI] 0.07 [0.01-0.32] and 0.29 [0.10-0.82], respectively).

CONCLUSION: This study suggests that small bowel resection and prolonged salicylates use may protect against SBA in CD patients.

[MeSH-major] Adenocarcinoma / etiology. Crohn Disease / complications. Intestinal Neoplasms / etiology. Intestine, Small

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[CommentIn] Inflamm Bowel Dis. 2009 Sep;15(9):1434-5 [19202570.001]

(PMID = 18564124.001).

[ISSN] 1572-0241

[Journal-full-title] The American journal of gastroenterology

[ISO-abbreviation] Am. J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Salicylates

   

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[Title] Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases.

Small intestinal adenocarcinoma is a rare malignant neoplasm, and its clinicopathologic characteristics have not been well elucidated.

A total of 197 small intestinal adenocarcinoma cases were collected from 22 institutions in South Korea and were evaluated for clinicopathologic factors that affect the prognosis of small intestinal adenocarcinoma patients using univariate and multivariate analyses.

The median survival time for all small intestinal adenocarcinoma patients was 39.7 months.

Compared with small intestinal adenocarcinomas without accompanying sporadic adenomas, small intestinal adenocarcinomas with accompanying adenomas were more well differentiated (P < .0001), with a more polypoid growth pattern (P < .0001), a lower pT classification (P < .0001), less perineural invasion (P = .01), and less lymphatic invasion (P = .03).

Small intestinal adenocarcinoma patients with associated sporadic adenomas (77%) had a significantly better 5-year survival rate than those without sporadic adenomas (38%, P = .02).

By univariate analysis, small intestinal adenocarcinoma patients had significantly different survival based on pT classification (P = .003), lymph node metastasis (P < .0001), distal location (jejunal and ileal carcinomas) (P = .003), retroperitoneal tumor seeding (P < .0001), vascular invasion (P = .007), lymphatic invasion (P = .001), peritumoral dysplasia (P = .004), and radiation therapy (P = .006).

In conclusion, (1) small intestinal adenocarcinomas are diagnosed at an advanced disease stage; therefore, the development of strategies for detection at an earlier stage is needed. (2) Small intestinal adenocarcinoma patients with an adenomatous component had a better survival than those without an adenomatous component. (3) Lymph node metastasis and distal location (jejunum and ileum) of tumor are the most important independent prognostic factors.

[MeSH-major] Adenocarcinoma / pathology. Duodenal Neoplasms / pathology. Ileal Neoplasms / pathology. Jejunal Neoplasms / pathology

[MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intestine, Small / pathology. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Prognosis

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[Copyright] 2010 Elsevier Inc. All rights reserved.

(PMID = 20334897.001).

[ISSN] 1532-8392

[Journal-full-title] Human pathology

[ISO-abbreviation] Hum. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Primary adenocarcinoma of the small intestine: presentation, prognostic factors and clinical outcome.

BACKGROUND: Malignant small intestine tumor accounts for 0.1-0.3% of all malignancies.

Although primary adenocarcinoma is the most common histologic subtype, there is no report of the clinical characteristics and natural history in the Asian population.

METHODS: We conducted retrospective analysis for the patients with the small intestine adenocarcinoma to explore the clinical characteristics and prognosis.

All patients with adenocarcinoma of small intestine diagnosed between March 1997 and March 2007 in the Catholic Medical Center in Korea were identified through the cancer registry.

CONCLUSIONS: The prognosis of primary adenocarcinoma of small intestine was poor, especially in cases where curative resection could not to be performed.

[MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small / pathology

[MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Female. Humans. Korea. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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(PMID = 18997182.001).

[ISSN] 1465-3621

[Journal-full-title] Japanese journal of clinical oncology

[ISO-abbreviation] Jpn. J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article; Multicenter Study

[Publication-country] England

   

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BACKGROUND: There is very small occurrence of adenocarcinoma in the small bowel.

We present a case of primary duodenal adenocarcinoma and discuss the findings of the case diagnostic modalities, current knowledge on the molecular biology behind small bowel neoplasms and treatment options.

CASE: The patient had a history of iron deficiency anemia and occult bleeding with extensive workup consisting of upper endoscopy, colonoscopy, capsule endoscopy, upper gastrointestinal series with small bowel follow through and push enteroscopy.

Due to persistent abdominal pain and iron deficiency anemia the patient underwent push enteroscopy which revealed adenocarcinoma of the duodenum.

The patient underwent en-bloc duodenectomy which revealed T3N1M0 adenocarcinoma of the 4th portion of the duodenum.

CONCLUSIONS: Primary duodenal carcinoma, although rare should be considered in the differential diagnosis of occult gastrointestinal bleeding when evaluation of the lower and upper GI tract is unremarkable.

We discuss the current evaluation and management of this small bowel neoplasm.

[MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Duodenal Neoplasms / diagnosis

[MeSH-minor] Aged. Diagnosis, Differential. Duodenoscopy. Female. Humans. Laparotomy. Ligaments. Tomography, X-Ray Computed

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(PMID = 20849628.001).

[ISSN] 1471-230X

[Journal-full-title] BMC gastroenterology

[ISO-abbreviation] BMC Gastroenterol

[Language] eng

[Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor

[Other-IDs] NLM/ PMC2949773

   

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[Title] Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database.

BACKGROUND: The presence of distant metastases and the completeness of resection are important prognostic factors in patients with small bowel adenocarcinoma (SBA); however, the influence of lymph node metastasis on patient outcome has not been well characterized.

[MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small. Lymph Nodes / pathology

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[Copyright] Copyright © 2010 American Cancer Society.

(PMID = 20715162.001).

[ISSN] 0008-543X

[Journal-full-title] Cancer

[ISO-abbreviation] Cancer

[Language] eng

[Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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[Title] Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient.

[MeSH-major] Adenocarcinoma / pathology. Crohn Disease / etiology. Ileal Neoplasms / pathology. Intestinal Obstruction / etiology

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(PMID = 19280822.001).

[ISSN] 0003-1348

[Journal-full-title] The American surgeon

[ISO-abbreviation] Am Surg

[Language] eng

[Publication-type] Case Reports; Letter

[Publication-country] United States

   

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[Title] Association of celiac disease and intestinal lymphomas and other cancers.

Celiac disease (CD) is associated with intestinal lymphoma and other forms of cancer, especially adenocarcinoma of the small intestine, of the pharynx, and of the esophagus.

Enteropathy-associated T-cell lymphoma (EATL) is a rare form of high-grade, T-cell non-Hodgkin lymphoma (NHL) of the upper small intestine that is specifically associated with CD.

EATL derives from a clonal proliferation of intraepithelial lymphocytes and is often disseminated at diagnosis.

[MeSH-major] Adenocarcinoma / etiology. Celiac Disease / complications. Gastrointestinal Neoplasms / etiology. Intestinal Neoplasms / etiology. Lymphoma, T-Cell / etiology

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(PMID = 15825131.001).

[ISSN] 0016-5085

[Journal-full-title] Gastroenterology

[ISO-abbreviation] Gastroenterology

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 8002-80-0 / Glutens

[Number-of-references] 40

   

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[Title] Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma.

[MeSH-major] Acetabulum. Adenocarcinoma / secondary. Bone Neoplasms / secondary. Jejunal Neoplasms / pathology

[MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed

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(PMID = 18040646.001).

[ISSN] 0949-2658

[Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

[ISO-abbreviation] J Orthop Sci

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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[Title] Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study.

However, the coexistence of neurofibromatosis with small-bowel adenocarcinoma is exceedingly rare.

We present an uncommon case of neurofibromatosis type 1, involving the small bowel in a 73-year-old man, who was admitted to our department with signs of acute abdomen.

These nodules obstructed ileal lumen, while the intestine wall was perforated in one point.

Histology revealed neurofibromatosis type 1 with malignant transformation to small-bowel adenocarcinoma.

We suggest that adenocarcinoma of small bowel should be considered in the evaluation of acute abdominal pain in neurofibromatosis patients.

[MeSH-major] Adenocarcinoma / pathology. Ileal Neoplasms / pathology. Intestine, Small / pathology. Neoplasms, Multiple Primary / pathology. Neurofibromatosis 1 / pathology

[MeSH-minor] Abdomen, Acute / etiology. Aged. Follow-Up Studies. Humans. Intestinal Obstruction / etiology. Intestinal Obstruction / pathology. Male. Tomography, X-Ray Computed

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(PMID = 19473375.001).

[ISSN] 1365-2354

[Journal-full-title] European journal of cancer care

[ISO-abbreviation] Eur J Cancer Care (Engl)

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

   

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[Title] Small-bowel capsule endoscopy diagnoses early and advanced neoplasms in asymptomatic patients with Lynch syndrome.

BACKGROUND AND STUDY AIMS: Patients with Lynch syndrome are at increased risk of developing small-bowel adenocarcinoma, which usually has a bad prognosis and needs to be diagnosed early.

RESULTS: Histologically confirmed small-bowel neoplasms were diagnosed in three patients (8.6 %): one adenocarcinoma (T3N0M0) and two adenomas with low-grade dysplasia.

CT enteroclysis raised suspicion of one neoplasm (adenocarcinoma) but missed the two others.

The clinical usefulness of systematic small-bowel screening in these patients should be confirmed through large prospective studies.

[MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Capsule Endoscopy. Colorectal Neoplasms, Hereditary Nonpolyposis / complications. Intestinal Neoplasms / diagnosis. Intestine, Small

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[Copyright] © Georg Thieme Verlag KG Stuttgart · New York.

(PMID = 20821360.001).

[ISSN] 1438-8812

[Journal-full-title] Endoscopy

[ISO-abbreviation] Endoscopy

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

[Chemical-registry-number] 0 / Contrast Media

   

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[Title] Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.

Patients with long-standing ulcerative colitis and Crohn's disease have an increased risk of developing colorectal cancer and patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.

Colorectal cancer appearing on the ground of inflammatory bowel disease is the result of a process which is believed to begin from no dysplasia progressing to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma, although colorectal cancer can arise without proceeding through each of these steps.

[MeSH-major] Cell Transformation, Neoplastic. Colorectal Neoplasms / epidemiology. Inflammatory Bowel Diseases / epidemiology

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(PMID = 19596953.001).

[ISSN] 1791-7530

[Journal-full-title] Anticancer research

[ISO-abbreviation] Anticancer Res.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Greece

[Number-of-references] 94

   

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[Title] Acute myelogenous leukemia following irinotecan-based chemotherapy for adenocarcinoma of the small intestine.

[MeSH-major] Adenocarcinoma / drug therapy. Camptothecin / analogs & derivatives. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology. Leukemia, Myeloid, Acute / drug therapy

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(PMID = 17487750.001).

[ISSN] 1042-8194

[Journal-full-title] Leukemia & lymphoma

[ISO-abbreviation] Leuk. Lymphoma

[Language] eng

[Publication-type] Case Reports; Letter

[Publication-country] England

[Chemical-registry-number] 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; IFL protocol

   

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[Title] Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature.

Primary adenocarcinoma of the ileum is an uncommon gastrointestinal malignancy, the symptoms of which are often insidious in onset.

This case history highlights the previously unreported finding of ileal adenocarcinoma presenting with mucusuria, caused by local invasion of the bladder in a 44-year-old male.

A review of the literature is included to highlight the incidence, risk factors, clinical presentation, investigation, and current management of adenocarcinoma of the small bowel.

[MeSH-major] Adenocarcinoma / secondary. Ileal Neoplasms / pathology. Intestinal Fistula / diagnosis. Urinary Bladder Fistula / diagnosis. Urinary Bladder Neoplasms / secondary

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(PMID = 16119711.001).

[ISSN] 0020-8868

[Journal-full-title] International surgery

[ISO-abbreviation] Int Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

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[Title] Chemotherapeutic management of small bowel adenocarcinoma associated with Crohn's disease.

Four patients with metastatic primary small bowel adenocarcinoma associated with Crohn's disease were successfully treated with low dose combination chemotherapy consisting of 5-fluorouracil, leucovorin and irinotecan with or without gemcitabine.

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Crohn Disease / complications. Duodenal Neoplasms / drug therapy. Ileal Neoplasms / drug therapy. Jejunal Neoplasms / drug therapy

[MeSH-minor] Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Female. Humans. Intestine, Small / pathology. Leucovorin / administration & dosage. Male. Remission Induction. Survival Analysis

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(PMID = 17127233.001).

[ISSN] 1120-009X

[Journal-full-title] Journal of chemotherapy (Florence, Italy)

[ISO-abbreviation] J Chemother

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

[Chemical-registry-number] 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; XT3Z54Z28A / Camptothecin

   

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[Title] Adenocarcinoma as a complication of small bowel Crohn's disease.

Carcinoma is a recognized but rare complication of small bowel Crohn's disease.

This case series emphasizes the importance of considering this diagnosis in patients with small bowel Crohn's disease.

We report three cases in which patients were treated for presumed exacerbations of Crohn's, but were subsequently found to have underlying small bowel adenocarcinoma.

[MeSH-major] Adenocarcinoma / etiology. Crohn Disease / complications. Ileal Neoplasms / etiology. Jejunal Neoplasms / etiology

[MeSH-minor] Adult. Fatal Outcome. Humans. Intestinal Obstruction / etiology. Male. Middle Aged. Tomography, X-Ray Computed

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(PMID = 16215441.001).

[ISSN] 0954-691X

[Journal-full-title] European journal of gastroenterology & hepatology

[ISO-abbreviation] Eur J Gastroenterol Hepatol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

   

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[Title] Cancer in inflammatory bowel disease.

Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC).

Colon cancer risk in inflammatory bowel disease increases with longer duration of colitis, greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of the bowel.

Patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.

Other extra intestinal cancers, such as hepatobiliary and hematopoietic cancer, have shown variable incidence rates.

[MeSH-major] Colorectal Neoplasms / physiopathology. Inflammatory Bowel Diseases / physiopathology. Neoplasms / physiopathology

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(PMID = 18200660.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] China

[Number-of-references] 118

[Other-IDs] NLM/ PMC2679126

   

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[Title] Chemotherapy for small-bowel Adenocarcinoma at a single institution.

PURPOSE: Small-bowel adenocarcinoma (SBA) is rare.

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy

[MeSH-minor] Adult. Aged. Camptothecin / administration & dosage. Camptothecin / adverse effects. Camptothecin / analogs & derivatives. Disease Progression. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Follow-Up Studies. Humans. Intestine, Small / diagnostic imaging. Leucovorin / administration & dosage. Leucovorin / adverse effects. Male. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed. Vitamin B Complex / administration & dosage. Vitamin B Complex / adverse effects

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(PMID = 19132464.001).

[ISSN] 0941-1291

[Journal-full-title] Surgery today

[ISO-abbreviation] Surg. Today

[Language] eng

[Publication-type] Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0H43101T0J / irinotecan; 12001-76-2 / Vitamin B Complex; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin

   

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[Title] Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma.

Small intestinal adenocarcinoma is an uncommon neoplasm morphologically similar to or indistinguishable from colorectal adenocarcinoma.

Although much has been learned about genetic pathways critical to colorectal tumorigenesis, little is known about molecular alterations involved in the development of small intestinal adenocarcinoma.

In this study, we immunohistochemically compared non-ampullary small intestinal adenocarcinomas with sporadic colorectal adenocarcinomas for the expression of several proteins known to serve pivotal roles in colorectal tumorigenesis.

The results show that complete loss of adenomatous polyposis coli immunoreactivity, presumably resulting from its gene mutations, was observed in eight of 26 (31%) small intestinal adenocarcinomas and 36 of 51 (71%) colorectal adenocarcinomas (P = 0.0008).

Nuclear localization of beta-catenin, an indirect evidence of deregulated Wnt signaling pathway, was observed in 5 (19%) small intestinal adenocarcinomas and 36 (71%) colorectal adenocarcinomas (P<0.0001).

Total lack of nuclear staining for one or more of the DNA mismatch repair enzymes occurred in a similar low frequency in both small intestinal and colorectal adenocarcinomas, seen in two of 25 (8%) and 10 of 47 (21%) cases, respectively (P = 0.1958).

The frequencies of aberrant p53 and RB expression were also similar between small intestinal and colorectal adenocarcinomas.

These observations indicate that defects in the Wnt and microsatellite instability pathways occur in over 90% of colorectal adenocarcinomas, but in only 40% of small intestinal adenocarcinomas.

Small intestinal tumorigenesis appears to follow a distinct, yet unidentified, molecular pathway(s) from its colorectal counterpart despite their morphologic similarity.

[MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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(PMID = 16501564.001).

[ISSN] 0893-3952

[Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

[ISO-abbreviation] Mod. Pathol.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Retinoblastoma Protein; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin

   

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[Title] No association of primary adenocarcinomas of the small bowel with Epstein-Barr virus infection.

Adenocarcinomas of the small bowel comprise a very rare entity, with little knowledge about molecular properties and etiological aspects.

We have investigated the prevalence of EBER expression (EBV-encoded small RNAs) in a series of small bowel adenocarcinomas (n=56) utilizing RNA in situ hybridization (EBER-RISH).

A surgical series of 82 primary resected gastric (n=36) or cardiac (n=46) adenocarcinomas (TU Munich) was used as control group.

None of the 56 small bowel carcinomas exhibited EBER expression whereas in the control group the rate of EBER expression accounted for 4.4% in the group of cardia carcinomas and 8.6% in the group of gastric cancers.

These results indicate that EBV infection plays no etiologic role in primary small bowel adenocarcinomas.

[MeSH-major] Adenocarcinoma / virology. Epstein-Barr Virus Infections / virology. Herpesvirus 4, Human / genetics. Intestinal Neoplasms / virology. Intestine, Small / virology. Stomach Neoplasms / virology

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[Copyright] (c) 2006 Wiley-Liss, Inc.

(PMID = 16493667.001).

[ISSN] 0899-1987

[Journal-full-title] Molecular carcinogenesis

[ISO-abbreviation] Mol. Carcinog.

[Language] eng

[Publication-type] Journal Article; Multicenter Study

[Publication-country] United States

[Chemical-registry-number] 0 / RNA, Viral

   

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[Title] [Primary small bowel neoplasms as a complication of celiac disease].

[Transliterated title] Neoplasias primarias de intestino delgado como complicación de la enfermedad celíaca.

The most serious complication in these patients is the development of neoplasms, the most frequent being enteropathy-associated T-cell lymphoma; however, an increase in the incidence of small bowel adenocarcinoma has also been described.

We present two cases of small bowel carcinoma in patients with celiac disease, which were diagnosed at the onset of the disease.

[MeSH-major] Adenocarcinoma / etiology. Celiac Disease / complications. Duodenal Neoplasms / etiology. Ileal Neoplasms / etiology

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(PMID = 19625106.001).

[ISSN] 0210-5705

[Journal-full-title] Gastroenterología y hepatología

[ISO-abbreviation] Gastroenterol Hepatol

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Spain

   

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[Title] Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma.

We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male.

Adenocarcinoma without stromal invasion was observed adjacent to the small intestinal mucosa.

Immunohistochemistry of the adenocarcinoma tissue revealed p53 overexpression and high Ki-67 labeling index as well as positive staining for CD10, cytokeratin 7, and cytokeratin 20.

Therefore, the diagnosis of small intestinal adenocarcinoma was made.

To our knowledge, this is the first case of small intestinal adenocarcinoma arising in retroperitoneal mature cystic teratoma.

A unique feature of this case is that malignant transformation in retroperitoneal mature teratoma arose even in the fully developed intestine.

[MeSH-major] Adenocarcinoma / pathology. Neoplasms, Multiple Primary / pathology. Retroperitoneal Neoplasms / pathology. Teratoma / pathology

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[Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.

[ErratumIn] Pathol Int. 2010 Dec;60(12):798

(PMID = 20846270.001).

[ISSN] 1440-1827

[Journal-full-title] Pathology international

[ISO-abbreviation] Pathol. Int.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Australia

   

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[Title] Small-bowel adenocarcinoma: case report and review of literature on diagnosis of small-bowel tumors.

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(PMID = 21960822.001).

[ISSN] 1554-7914

[Journal-full-title] Gastroenterology & hepatology

[ISO-abbreviation] Gastroenterol Hepatol (N Y)

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC3099353

   

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[Title] Phase II study of 5-fluorouracil, doxorubicin, and mitomycin C for metastatic small bowel adenocarcinoma.

BACKGROUND: Small bowel adenocarcinoma is a rare gastrointestinal malignancy that is treated primarily with surgery.

This study aimed to document the response rate and survival time for patients with advanced small bowel adenocarcinoma who were not surgically curable and were treated with a regimen of 5-fluorouracil (5-FU), mitomycin C (Mutamycin; Bristol-Myers Squibb; Princeton, NJ), and doxorubicin (Adriamycin; Bedford Laboratories; Bedford, OH), the FAM regimen.

CONCLUSIONS: The FAM regimen was active and tolerable for patients with advanced small bowel adenocarcinoma; however, the results were no better than those seen with other chemotherapy combinations.

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy

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Hazardous Substances Data Bank. DOXORUBICIN .

Hazardous Substances Data Bank. MITOMYCIN C .

Hazardous Substances Data Bank. FLUOROURACIL .

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(PMID = 15709215.001).

[ISSN] 1083-7159

[Journal-full-title] The oncologist

[ISO-abbreviation] Oncologist

[Language] eng

[Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study

[Publication-country] United States

[Chemical-registry-number] 50SG953SK6 / Mitomycin; 80168379AG / Doxorubicin; U3P01618RT / Fluorouracil

   

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[Title] Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma.

Small bowel adenocarcinoma is a rare etiology for PC.

METHODS: From a prospective database of IPHC patients, six patients diagnosed with PC from adenocarcinoma of the small bowel were identified.

Median survival after diagnosis of small bowel adenocarcinoma was 54 months, while median survival after CS and IPHC for PC was 30.1 months.

CONCLUSIONS: Small bowel adenocarcinoma with PC remains an unusual therapeutic challenge.

[MeSH-major] Adenocarcinoma / drug therapy. Hyperthermia, Induced. Ileal Neoplasms / drug therapy. Jejunal Neoplasms / drug therapy. Peritoneal Neoplasms / drug therapy

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[Copyright] Copyright 2005 Wiley-Liss, Inc.

(PMID = 16028284.001).

[ISSN] 0022-4790

[Journal-full-title] Journal of surgical oncology

[ISO-abbreviation] J Surg Oncol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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[Title] Double balloon enteroscopy detects small bowel mass lesions missed by capsule endoscopy.

BACKGROUND: Small bowel mass lesions (SBML) are a relatively common cause of obscure gastrointestinal bleeding (OGIB).

Their detection has been limited by the inability to endoscopically examine the entire small intestine.

A small bowel mass lesion was identified in 18 patients.

Capsule endoscopy failed to identify all four cases of primary small bowel adenocarcinoma.

CONCLUSIONS: Double balloon enteroscopy detects small bowel mass lesions responsible for OGIB that are missed by CE.

Additional endoscopic evaluation of the small bowel by DBE or intraoperative enteroscopy should be performed in patients with ongoing OGIB and negative or non-specific findings on CE.

[MeSH-major] Capsule Endoscopy. Diagnostic Errors / prevention & control. Endoscopy, Gastrointestinal / methods. Gastrointestinal Hemorrhage / etiology. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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(PMID = 18270840.001).

[ISSN] 0163-2116

[Journal-full-title] Digestive diseases and sciences

[ISO-abbreviation] Dig. Dis. Sci.

[Language] eng

[Publication-type] Evaluation Studies; Journal Article; Multicenter Study

[Publication-country] United States

   

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[Title] Surgical management and outcome in primary adenocarcinoma of the small bowel.

BACKGROUND: Primary adenocarcinoma of the small bowel is a rare malignancy and is associated with poor survival outcome.

METHODS: Between 1971 and 2005, 64 patients with primary adenocarcinoma of the small bowel were treated at our institution.

RESULTS: The most common clinical features at presentation included abdominal pain (n = 33; 51.6%) or bowel obstruction (n = 20; 31.3%).

The most frequently involved portion of the small bowel was the duodenum (n = 41; 64%).

A segmental bowel resection was performed in 30 patients and pancreaticoduodenectomy in 14 patients.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / pathology. Intestinal Neoplasms / surgery

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(PMID = 17549572.001).

[ISSN] 1068-9265

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

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[Title] Small bowel adenocarcinoma: understaged and undertreated?

BACKGROUND: Primary small bowel adenocarcinoma (SBA) is a rare, chemoresistant tumor with an aggressive clinical nature.

[MeSH-major] Intestinal Neoplasms / pathology. Intestine, Small / pathology. Lymph Nodes / pathology

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(PMID = 20458546.001).

[ISSN] 1534-4681

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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[Title] Adenocarcinoma of the small bowel: a surgical dilemma.

Malignant tumors of the small intestine are among the rarest types of gastrointestinal cancers.

Due to their infrequent occurrence and the multitude of tumor types (viz, adenocarcinomas, carcinoids, sarcomas, and lymphomas), not much is known about their natural history and presentation, and there is often delay in the diagnosis.

Adenocarcinoma is the commonest histologic type of small bowel cancer.

In this article, a case of adenocarcinoma of the jejunum presenting as an abdominal lump is presented, along with a review of the literature.

[MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Jejunal Neoplasms / pathology. Jejunal Neoplasms / surgery

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(PMID = 19794274.001).

[ISSN] 1998-4049

[Journal-full-title] Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

[ISO-abbreviation] Saudi J Gastroenterol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Saudi Arabia

[Other-IDs] NLM/ PMC2981845

   

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To address this issue, we studied the FDG uptake in AOM-induced rat colorectal adenocarcinoma (CRC) and correlated this with histopathological findings.

RESULTS: Macroscopic examination revealed 21 tumors (7 located in the small bowel and 14 in the colon) in 19 rats.

On histological examination, we found 10 colonic adenocarcinomas (the first being observed at Week 22) and 7 adenocarcinoma in the small bowel.

The [(18)F]FDG accumulation in small intestine carcinomas was well beyond background accumulation (P<.0001).

On PET scanning, two rats showed focal accumulation of the abdominal area, corresponding to small intestine carcinomas.

CONCLUSION: Adenocarcinomas had a significantly higher [(18)F]FDG uptake than background bowel uptake.

[MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / radionuclide imaging. Colonic Neoplasms / metabolism. Colonic Neoplasms / radionuclide imaging. Disease Models, Animal. Fluorodeoxyglucose F18 / pharmacokinetics

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(PMID = 16546679.001).

[ISSN] 0969-8051

[Journal-full-title] Nuclear medicine and biology

[ISO-abbreviation] Nucl. Med. Biol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; MO0N1J0SEN / Azoxymethane

   

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[Title] Sporadic flat ileal adenocarcinoma: an intriguing challenge in the comprehension of a rare neoplasia and its genesis. Case report and review of literature.

Small bowel adenocarcinoma is a rare tumor, with a still not well studied tumorigenesis process, usually presenting in an advanced stage.

The clinical diagnosis is often difficult; surgery is the treatment of choice when feasible, while the chemotherapeutic approach is still not well standardized.

The gross appearance resembled an inflammatory bowel disease, but microscopic examination revealed the extensive presence of an infiltrating ileal adenocarcinoma.

Literature about small bowel adenocarcinoma has been reviewed for better understanding its pathogenesis.

[MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Ileal Neoplasms / pathology. Ileal Neoplasms / surgery

[MeSH-minor] Aged. Anastomosis, Surgical. Diagnosis, Differential. Digestive System Surgical Procedures / methods. Humans. Male. Treatment Outcome

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(PMID = 19351457.001).

[ISSN] 0391-9005

[Journal-full-title] Il Giornale di chirurgia

[ISO-abbreviation] G Chir

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] Italy

[Number-of-references] 44

   

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[Title] Large-scale N-terminal deletions but not point mutations stabilize beta-catenin in small bowel carcinomas, suggesting divergent molecular pathways of small and large intestinal carcinogenesis.

Small intestinal adenocarcinoma is rare and its molecular pathogenesis is incompletely understood.

In order to elucidate the molecular background of beta-catenin stabilization in small intestinal adenocarcinoma, we investigated 20 non-familial adenomatous polyposis coli (FAP)-associated tumours, including five microsatellite-unstable carcinomas for beta-catenin alterations, by immunohistochemistry, western blot analysis and sequence analysis on the RNA and DNA levels.

Our data show that large intragenic CTNNB1 mutations stabilize beta-catenin in small intestinal adenocarcinomas and influence the subcellular distribution of the protein.

In contrast to colon carcinomas, neither APC nor CTNNB1 point mutations seem to play a significant role in carcinogenesis, indicating divergent mechanisms of wnt/wingless control in the small and the large intestine.

[MeSH-major] Adenocarcinoma / genetics. Intestinal Neoplasms / genetics. Sequence Deletion. beta Catenin / genetics

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[Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland.

(PMID = 18491352.001).

[ISSN] 0022-3417

[Journal-full-title] The Journal of pathology

[ISO-abbreviation] J. Pathol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Wnt Proteins; 0 / beta Catenin

   

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[Title] Intestinal cancer in patients with Crohn's disease.

BACKGROUND: Surveillance of intestinal cancer in Crohn's disease (CD) has often been advocated.

To date, no clear evidence exists whether CD patients are at special risk for intestinal cancer.

An increased incidence of small bowel adenocarcinoma is suggested.

We report our experience with 10 cases of CD complicated by intestinal adenocarcinoma.

Data of patients that developed carcinoma within Crohn's lesions of either small or large bowel were analyzed.

Mean age at the time of diagnosis of CD was 43 years.

Mean duration of CD until diagnosis of cancer was 14 years.

Delayed diagnosis resulted in a poor prognosis.

[MeSH-major] Crohn Disease / complications. Intestinal Neoplasms / etiology

[MeSH-minor] Adult. Colorectal Neoplasms. Databases, Factual. Female. Humans. Ileitis. Incidence. Intestinal Fistula. Male. Middle Aged. Survival Rate

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[Cites] Gastroenterology. 1988 Apr;94(4):1089-91 [3345879.001]

(PMID = 16847674.001).

[ISSN] 0179-1958

[Journal-full-title] International journal of colorectal disease

[ISO-abbreviation] Int J Colorectal Dis

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany