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1
adenocarcinoma of small intestine disorder 2005:2010[pubdate] *count=100
140 results
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adenocarcinoma of small intestine disorder
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Items 1 to 100 of about 140
1.
Michel S, Kloor M, Singh S, Gdynia G, Roth W, von Knebel Doeberitz M, Schirmacher P, Bläker H:
Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation.
Mol Carcinog
; 2010 Feb;49(2):175-82
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[Title]
Coding microsatellite instability analysis in microsatellite unstable
small
intestinal adenocarcinomas
identifies MARCKS as a common target of inactivation.
Approximately 15%
of small
intestinal adenocarcinomas
show inactivation of DNA-mismatch repair (MMR) and display high-level microsatellite instability (MSI-H).
To investigate the cMSI selection in
small
intestinal
carcinogenesis 56
adenocarcinomas
were tested for MSI.
Since little is known about MARCKS expression in the
intestine
, we analyzed MARCKS protein expression in 31 carcinomas.
In line with cMSI induced functional inactivation of MARCKS, 8 out of 11 MSI-H
adenocarcinomas
showed regional or complete loss of the protein.
In microsatellite stable (MSS)
small
bowel
adenocarcinoma
, loss of MARCKS expression was seen in 2 out of 20 tumors (10%).
In conclusion, we herein present a cMSI profile of MSI-H
small
intestinal adenocarcinomas
identifying MARCKS as a frequent target of mutation.
Loss of MARCKS protein expression suggests a significant role of MARCKS inactivation in the pathogenesis
of small
intestinal adenocarcinomas
.
[MeSH-major]
Adenocarcinoma
/ genetics.
Intestinal
Neoplasms / genetics.
Intestine
,
Small
/ pathology. Intracellular Signaling Peptides and Proteins / genetics. Membrane Proteins / genetics. Microsatellite Repeats / genetics
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(PMID = 19852062.001).
[ISSN]
1098-2744
[Journal-full-title]
Molecular carcinogenesis
[ISO-abbreviation]
Mol. Carcinog.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 125267-21-2 / myristoylated alanine-rich C kinase substrate
2.
Gonda TA, Khan SU, Cheng J, Lewis SK, Rubin M, Green PH:
Association of intussusception and celiac disease in adults.
Dig Dis Sci
; 2010 Oct;55(10):2899-903
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Two patients were found to have lead-point intussusceptions and both had
small
-
bowel
adenocarcinoma
, and 10/14 had severe villous atrophy (subtotal or total).
Among those with established celiac disease, IS was detected early, within 3 years of
diagnosis
.
Adenocarcinoma
needs to be excluded.
[MeSH-minor]
Abdominal Pain / epidemiology. Abdominal Pain / pathology.
Adenocarcinoma
/ epidemiology.
Adenocarcinoma
/ pathology. Adult. Atrophy. Biopsy. Capsule Endoscopy. Chi-Square Distribution. Databases, Factual. Female. Follow-Up Studies. Humans. Incidental Findings.
Intestinal
Neoplasms / epidemiology.
Intestinal
Neoplasms / pathology. Male. Middle Aged
Genetic Alliance.
consumer health - Celiac Disease
.
MedlinePlus Health Information.
consumer health - Celiac Disease
.
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[ISSN]
1573-2568
[Journal-full-title]
Digestive diseases and sciences
[ISO-abbreviation]
Dig. Dis. Sci.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
3.
Moon YW, Rha SY, Shin SJ, Chang H, Shim HS, Roh JK:
Adenocarcinoma of the small bowel at a single Korean institute: management and prognosticators.
J Cancer Res Clin Oncol
; 2010 Mar;136(3):387-94
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[Title]
Adenocarcinoma of
the
small
bowel
at a single Korean institute: management and prognosticators.
PURPOSE:
Small
bowel
adenocarcinoma
(SBA) is a rare malignancy with a poor outcome.
CONCLUSIONS: Early
diagnosis
is crucial to improve outcomes of SBA with respect to increasing resectability.
[MeSH-major]
Adenocarcinoma
/
diagnosis
.
Adenocarcinoma
/ therapy.
Intestinal
Neoplasms /
diagnosis
.
Intestinal
Neoplasms / therapy
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Algorithms. Chemotherapy, Adjuvant / methods. Chemotherapy, Adjuvant / utilization. Digestive System Surgical Procedures / methods. Female. Humans.
Intestine
,
Small
/ pathology. Korea. Male. Middle Aged. Prognosis. Recurrence. Retrospective Studies. Treatment Outcome. Young Adult
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[ISO-abbreviation]
J. Cancer Res. Clin. Oncol.
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
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4.
Manfredi S, Thiebot T, Henno S, Falize L, Bretagne JF, Meunier B:
Complete response of an initially non-surgical adenocarcinoma of the duodenum to chemotherapy with the FOLFOX 4 regimen.
J Gastrointest Surg
; 2009 Dec;13(12):2309-13
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[Title]
Complete response of an initially non-surgical
adenocarcinoma of
the duodenum to chemotherapy with the FOLFOX 4 regimen.
INTRODUCTION: The incidence
of adenocarcinoma
of the
small
bowel
is very low in comparison with that of colorectal cancer.
No standard chemotherapy is defined for non-surgical
adenocarcinoma of
the
small
bowel
.
CASE REPORT: We report here the case of a young patient with an initially non-surgical
adenocarcinoma of
the duodenum treated in a palliative setting with the FOLFOX 4 chemotherapy regimen.
CONCLUSION: The FOLFOX 4 regimen seems to be efficacious for some
small
-
bowel adenocarcinomas
and can be expected to lead to downstaging.
[MeSH-major]
Adenocarcinoma
/ drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy
MedlinePlus Health Information.
consumer health - Intestinal Cancer
.
Hazardous Substances Data Bank.
FLUOROURACIL
.
Hazardous Substances Data Bank.
LEUCOVORIN
.
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[
7842287.001
]
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[
17031398.001
]
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Gastrointest Endosc Clin N Am. 2004 Jan;14(1):139-48
[
15062387.001
]
[Cites]
Arch Surg. 2002 May;137(5):564-70; discussion 570-1
[
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Gastroenterology. 1993 Dec;105(6):1716-23
[
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[Cites]
Gastroenterology. 1994 Dec;107(6):1675-9
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Cancer Epidemiol Biomarkers Prev. 1996 Feb;5(2):81-4
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Dig Dis Sci. 1992 Aug;37(8):1179-84
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[
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[
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[
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Cancer Epidemiol Biomarkers Prev. 1998 Mar;7(3):243-51
[
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Int J Epidemiol. 1996 Aug;25(4):722-8
[
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]
[Cites]
J Am Coll Surg. 1996 Aug;183(2):89-96
[
8696551.001
]
[Cites]
Ann Oncol. 2003;14 Suppl 5:v61-118
[
14684501.001
]
(PMID = 19585173.001).
[ISSN]
1873-4626
[Journal-full-title]
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
[ISO-abbreviation]
J. Gastrointest. Surg.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
5.
Halfdanarson TR, McWilliams RR, Donohue JH, Quevedo JF:
A single-institution experience with 491 cases of small bowel adenocarcinoma.
Am J Surg
; 2010 Jun;199(6):797-803
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[Title]
A single-institution experience with 491 cases
of small
bowel
adenocarcinoma
.
BACKGROUND: The optimal treatment
of small
bowel
adenocarcinoma
is unknown.
METHODS: The records of 491 patients with
small
bowel
adenocarcinoma
diagnosis
between 1970 and 2005 were reviewed for patient and tumor characteristics, treatment effects, and survival.
RESULTS: The median age at
diagnosis
was 62 years.
CONCLUSIONS: The prognosis of patients with
small
bowel
adenocarcinoma
is poor.
[MeSH-major]
Adenocarcinoma
/ surgery.
Intestinal
Neoplasms / surgery.
Intestine
,
Small
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[Copyright]
Published by Elsevier Inc.
(PMID = 20609724.001).
[ISSN]
1879-1883
[Journal-full-title]
American journal of surgery
[ISO-abbreviation]
Am. J. Surg.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
6.
Caruso S, Marrelli D, Pedrazzani C, Neri A, Mazzei MA, Onorati M, Corso G, Cerullo G, Roviello F:
A rare case of primary small bowel adenocarcinoma with intussusception.
Tumori
; 2010 Mar-Apr;96(2):355-7
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[Title]
A rare case of primary
small
bowel
adenocarcinoma
with intussusception.
In contrast with the colon tract, the incidence of primary malignancies in the
small
bowel
is very low.
We report the case of a 51-year-old man presenting with jejunal intussusception due to a primary
adenocarcinoma
.
The patient was referred to our division for
bowel
obstruction.
Histological examination of the specimen resulted in a
diagnosis
of a primary
adenocarcinoma of
the
small
bowel
.
In adult
intestinal
intussusception, resection without reduction is considered the optimal management if an underlying primary malignancy cannot be excluded.
[MeSH-major]
Adenocarcinoma
/ complications. Intussusception / etiology. Jejunal Diseases / etiology. Jejunal Neoplasms / complications
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.
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.
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(PMID = 20572601.001).
[ISSN]
0300-8916
[Journal-full-title]
Tumori
[ISO-abbreviation]
Tumori
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
7.
Dasari BV, Gardiner KR:
Management of adenocarcinoma of the small intestine.
Gastrointest Cancer Res
; 2009 May;3(3):121-2
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[Title]
Management
of adenocarcinoma
of the
small intestine
.
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[Cites]
Clin Gastroenterol Hepatol. 2008 Jun;6(6):671-6
[
18356113.001
]
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]
(PMID = 19626156.001).
[ISSN]
1934-7820
[Journal-full-title]
Gastrointestinal cancer research : GCR
[ISO-abbreviation]
Gastrointest Cancer Res
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ PMC2713137
8.
Tankova L, Berberova M, Damianov N, Tsankov Ts, Kovatchki D:
Preoperative diagnosis of jejunal adenocarcinoma--a case report.
J BUON
; 2008 Jan-Mar;13(1):123-6
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[Title]
Preoperative
diagnosis
of jejunal
adenocarcinoma
--a case report.
We report herein the case of a preoperatively diagnosed
small
bowel
adenocarcinoma
.
An US-guided fine (20 gauge) needle aspiration (FNA) cytology of the mass was performed and showed moderately differentiated
adenocarcinoma of
intestinal
origin.
On surgical exploration a jejunal tumor of high consistency was found, located 15 cm distantly from the Treitz ligament, infiltrating up to 2/3 of
the bowel
circumference and partly obstructing its lumen.
The histological evaluation of the resected material showed highly to moderately differentiated
adenocarcinoma
with 5 regional lymph node metastases.
The combination of US with Doppler and FNA established preoperatively the malignant
small
bowel
disease.
[MeSH-major]
Adenocarcinoma
/
diagnosis
. Jejunal Neoplasms /
diagnosis
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(PMID = 18404799.001).
[ISSN]
1107-0625
[Journal-full-title]
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
[ISO-abbreviation]
J BUON
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Greece
9.
Overman MJ, Varadhachary GR, Kopetz S, Adinin R, Lin E, Morris JS, Eng C, Abbruzzese JL, Wolff RA:
Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
J Clin Oncol
; 2009 Jun 1;27(16):2598-603
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[Title]
Phase II study of capecitabine and oxaliplatin for advanced
adenocarcinoma of
the
small
bowel
and ampulla of Vater.
PURPOSE:
Adenocarcinomas
of the
small
bowel
and ampulla of Vater represent rare cancers that have limited data regarding first-line therapy.
We conducted a phase II trial to evaluate the benefit of capecitabine in combination with oxaliplatin (CAPOX) in patients with advanced
adenocarcinoma of small
bowel
or ampullary origin.
CAPOX should be considered a new standard regimen for advanced
small
bowel
and ampullary
adenocarcinomas
.
[MeSH-major]
Adenocarcinoma
/ drug therapy. Ampulla of Vater / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Common Bile Duct Neoplasms / drug therapy.
Intestinal
Neoplasms / drug therapy.
Intestine
,
Small
/ pathology
COS Scholar Universe.
author profiles
.
ClinicalTrials.gov.
clinical trials - ClinicalTrials.gov
.
Hazardous Substances Data Bank.
CAPECITABINE
.
Hazardous Substances Data Bank.
FLUOROURACIL
.
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(PMID = 19164203.001).
[ISSN]
1527-7755
[Journal-full-title]
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
[ISO-abbreviation]
J. Clin. Oncol.
[Language]
eng
[Publication-type]
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
11.
Bulfoni A:
[Primary adenocarcinoma of jejunum with obscure gastrointestinal bleeding].
Clin Ter
; 2006 Sep-Oct;157(5):431-4
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[Title]
[Primary
adenocarcinoma of
jejunum with obscure gastrointestinal bleeding].
[Transliterated title]
Adenocarcinoma
primitivo
del
digiuno
ad
esteriorizzazione con enterorragia.
A case of primary
small
bowel
adenocarcinoma
is reported because of the rarity of this malignancy.
[MeSH-major]
Adenocarcinoma
. Gastrointestinal Hemorrhage / etiology. Jejunal Neoplasms
[MeSH-minor]
Capsule Endoscopy.
Diagnosis
, Differential. Female. Humans. Jejunum / pathology. Middle Aged. Occult Blood. Prognosis
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.
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.
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(PMID = 17147051.001).
[ISSN]
0009-9074
[Journal-full-title]
La Clinica terapeutica
[ISO-abbreviation]
Clin Ter
[Language]
ita
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Italy
12.
Ruiz-Tovar J, Martínez-Molina E, Morales V, Sanjuanbenito A:
[Primary small bowel adenocarcinoma].
Cir Esp
; 2009 Jun;85(6):354-9
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[Title]
[Primary
small
bowel
adenocarcinoma
].
[Transliterated title]
Adenocarcinoma
primario
de intestino delgado
.
INTRODUCTION: Primary
small
bowel
adenocarcinoma
is an uncommon tumour, with non-specific symptoms that cause a delay in
the diagnosis
and consequently a worse outcome for the patient.
MATERIAL AND METHOD: We performed a retrospective study of our experience with 17 patients diagnosed with primary
small
bowel
adenocarcinoma
, excluding all the cases suggesting secondary involvement of the
small
bowel
from an
adenocarcinoma
in other locations.
Those with duodenal tumours underwent 4 pancreaticoduodenectomies, 3 gastroenterostomies and 1 diagnostic biopsy; 6
bowel
resections with lymphadenectomy, 2 en-bloc resections and 1 by-pass were performed on those with jejuno-ileal tumours.
CONCLUSIONS: Curative treatment consists
of small
bowel
resection.
[MeSH-major]
Adenocarcinoma
. Duodenal Neoplasms. Ileal Neoplasms. Jejunal Neoplasms
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.
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(PMID = 19344893.001).
[ISSN]
0009-739X
[Journal-full-title]
Cirugía española
[ISO-abbreviation]
Cir Esp
[Language]
spa
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Spain
13.
Overman MJ, Kopetz S, Lin E, Abbruzzese JL, Wolff RA:
Is there a role for adjuvant therapy in resected adenocarcinoma of the small intestine.
Acta Oncol
; 2010 May;49(4):474-9
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[Title]
Is there a role for adjuvant therapy in resected
adenocarcinoma of
the
small intestine
.
BACKGROUND: The benefit of adjuvant therapy for resected
small
bowel
adenocarcinoma
has not been proven.
We undertook a retrospective analysis to evaluate the benefit of adjuvant therapy in a clearly defined patient population with curatively resected
small
bowel
adenocarcinoma
.
MATERIAL AND METHODS: We identified 54 patients with
small
bowel
adenocarcinoma
who underwent margin-negative surgical resection and were evaluated after surgery at the University of Texas, M. D.
DISCUSSION: The use of adjuvant therapy for curatively resected
small
bowel
adenocarcinoma
was associated with an improvement in DFS.
[MeSH-major]
Adenocarcinoma
/ therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Intestinal
Neoplasms / therapy.
Intestine
,
Small
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(PMID = 20397775.001).
[ISSN]
1651-226X
[Journal-full-title]
Acta oncologica (Stockholm, Sweden)
[ISO-abbreviation]
Acta Oncol
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
14.
Posey JA 3rd, Saif MW, Carlisle R, Goetz A, Rizzo J, Stevenson S, Rudoltz MS, Kwiatek J, Simmons P, Rowinsky EK, Takimoto CH, Tolcher AW:
Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas.
Clin Cancer Res
; 2005 Nov 1;11(21):7866-71
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Unconfirmed partial responses were observed in two patients, one with metastatic
small
bowel
adenocarcinoma
and the other with metastatic esophageal cancer.
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.
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.
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.
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.
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(PMID = 16278410.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
eng
[Grant]
United States / NCRR NIH HHS / RR / M01 RR00032
[Publication-type]
Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 30IQX730WE / Polyethylene Glycols; 581079-18-7 / pegamotecan; XT3Z54Z28A / Camptothecin
15.
Ausloos F, Scagnol I, Belaiche J:
[Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report].
Rev Med Liege
; 2009 Jul-Aug;64(7-8):394-7
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[Title]
[
Adenocarcinoma of
the
small
intestines complicating coeliac disease in an adult: case report].
[Transliterated title]
Adénocarcinome
de l
'
intestin
grêle compliquant une maladie coeliaque
de l
'adulte: à propos d'un cas.
This
small
bowel
adenocarcinoma
is rare and concerns less than 5% of the digestive neoplasias.
We are reporting the case of a 67-years-old woman whose coeliac disease has been complicated 5 years thereafter by a jejunal
adenocarcinoma
.
[MeSH-major]
Adenocarcinoma
/ complications.
Adenocarcinoma
/
diagnosis
. Celiac Disease / complications. Incidental Findings. Jejunal Neoplasms / complications. Jejunal Neoplasms /
diagnosis
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.
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(PMID = 19777919.001).
[ISSN]
0370-629X
[Journal-full-title]
Revue médicale de Liège
[ISO-abbreviation]
Rev Med Liege
[Language]
fre
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Belgium
16.
Yamaga Y, Ohana M, Nakamura T, Kikuchi S, Matsumura K, Takita M, Iwamoto S, Morisawa T, Miyajima S, Kida H, Okano A, Okinaga S, Kusumi F, Takakuwa H, Honjou G:
[A case of jejunal adenocarcinoma with serum DUPAN-2 elevation].
Nihon Shokakibyo Gakkai Zasshi
; 2010 Nov;107(11):1806-13
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[Title]
[A case of jejunal
adenocarcinoma
with serum DUPAN-2 elevation].
Ileus with ulcerated jejunal tumor was diagnosed and biopsy revealed
adenocarcinoma
.
Surgical resection was performed: both tumors were
adenocarcinoma
, but the ovarian tumor was considered to be metastatic clinically and histologically.
This case shows a possible relation between
small
bowel
adenocarcinoma
and DUPAN-2.
[MeSH-major]
Adenocarcinoma
/
diagnosis
. Antigens, Neoplasm / blood. Jejunal Neoplasms /
diagnosis
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.
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(PMID = 21071898.001).
[ISSN]
0446-6586
[Journal-full-title]
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
[ISO-abbreviation]
Nihon Shokakibyo Gakkai Zasshi
[Language]
jpn
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DU-PAN-2 antigen, human
17.
Chaiyasate K, Jain AK, Cheung LY, Jacobs MJ, Mittal VK:
Prognostic factors in primary adenocarcinoma of the small intestine: 13-year single institution experience.
World J Surg Oncol
; 2008;6:12
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[Title]
Prognostic factors in primary
adenocarcinoma of
the
small intestine
: 13-year single institution experience.
BACKGROUND:
Adenocarcinoma of
the
small
bowel
is a relatively rare malignancy as compared to the other malignancies of the gastrointestinal tract.
Nonspecific presentation and infrequent occurrence often leads to a delay in
diagnosis
and consequent poor prognosis.
METHODS: The medical records of a total of 27 patients treated for
adenocarcinoma of
the
small
bowel
at Providence Hospital and Medical Centers from year 1990 through 2003 were reviewed retrospectively.
RESULTS: The patients included nine males and eighteen females with a median age at
diagnosis
of 62 years.
Only 48% of the patients had an accurate preoperative
diagnosis
while another 33% had a
diagnosis
suspicious
of small
bowel
malignancy.
[MeSH-major]
Adenocarcinoma
/ mortality.
Adenocarcinoma
/ surgery.
Intestinal
Neoplasms / mortality.
Intestinal
Neoplasms / surgery.
Intestine
,
Small
/ pathology
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[Cites]
Cancer. 1999 Dec 15;86(12):2693-706
[
10594865.001
]
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CA Cancer J Clin. 2006 Mar-Apr;56(2):106-30
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(PMID = 18237404.001).
[ISSN]
1477-7819
[Journal-full-title]
World journal of surgical oncology
[ISO-abbreviation]
World J Surg Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC2253527
18.
Piton G, Cosnes J, Monnet E, Beaugerie L, Seksik P, Savoye G, Cadiot G, Flourie B, Capelle P, Marteau P, Lemann M, Colombel JF, Khouri E, Bonaz B, Carbonnel F:
Risk factors associated with small bowel adenocarcinoma in Crohn's disease: a case-control study.
Am J Gastroenterol
; 2008 Jul;103(7):1730-6
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[Title]
Risk factors associated with
small
bowel
adenocarcinoma
in Crohn's disease: a case-control study.
BACKGROUND AND AIMS: It is well established that Crohn's disease (CD) is associated with an increased risk
of small
bowel
adenocarcinoma
(SBA).
METHODS: In 11 French centers affiliated with the GETAID (Groupe d'Etude Thérapeutique
des
Affections Inflammatoires
du
Tube Digestif), we identified 29 patients with CD and SBA.
RESULTS: In univariate analysis, the cases had had significantly less
small
bowel
resection and received prolonged treatment with salicylates (more than 2 yr), less often than the controls (odds ratio, OR [95% confidence interval, CI] 0.07 [0.01-0.32] and 0.29 [0.10-0.82], respectively).
CONCLUSION: This study suggests that
small
bowel
resection and prolonged salicylates use may protect against SBA in CD patients.
[MeSH-major]
Adenocarcinoma
/ etiology. Crohn Disease / complications.
Intestinal
Neoplasms / etiology.
Intestine
,
Small
Genetic Alliance.
consumer health - Crohn Disease
.
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.
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[CommentIn]
Inflamm Bowel Dis. 2009 Sep;15(9):1434-5
[
19202570.001
]
(PMID = 18564124.001).
[ISSN]
1572-0241
[Journal-full-title]
The American journal of gastroenterology
[ISO-abbreviation]
Am. J. Gastroenterol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Salicylates
19.
Chang HK, Yu E, Kim J, Bae YK, Jang KT, Jung ES, Yoon GS, Kim JM, Oh YH, Bae HI, Kim GI, Jung SJ, Gu MJ, Kim JY, Jang KY, Jun SY, Eom DW, Kwon KW, Kang GH, Park JB, Hong S, Lee JS, Park JY, Hong SM, Korean Small Intestinal Cancer Study Group:
Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases.
Hum Pathol
; 2010 Aug;41(8):1087-96
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[Title]
Adenocarcinoma of
the
small intestine
: a multi-institutional study of 197 surgically resected cases.
Small
intestinal
adenocarcinoma
is a rare malignant neoplasm, and its clinicopathologic characteristics have not been well elucidated.
A total of 197
small
intestinal
adenocarcinoma
cases were collected from 22 institutions in South Korea and were evaluated for clinicopathologic factors that affect the prognosis
of small
intestinal
adenocarcinoma
patients using univariate and multivariate analyses.
The median survival time for all
small
intestinal
adenocarcinoma
patients was 39.7 months.
Compared with
small
intestinal adenocarcinomas
without accompanying sporadic adenomas,
small
intestinal adenocarcinomas
with accompanying adenomas were more well differentiated (P < .0001), with a more polypoid growth pattern (P < .0001), a lower pT classification (P < .0001), less perineural invasion (P = .01), and less lymphatic invasion (P = .03).
Small
intestinal
adenocarcinoma
patients with associated sporadic adenomas (77%) had a significantly better 5-year survival rate than those without sporadic adenomas (38%, P = .02).
By univariate analysis,
small
intestinal
adenocarcinoma
patients had significantly different survival based on pT classification (P = .003), lymph node metastasis (P < .0001), distal location (jejunal and ileal carcinomas) (P = .003), retroperitoneal tumor seeding (P < .0001), vascular invasion (P = .007), lymphatic invasion (P = .001), peritumoral dysplasia (P = .004), and radiation therapy (P = .006).
In conclusion, (1)
small
intestinal adenocarcinomas
are diagnosed at an advanced disease stage; therefore, the development of strategies for detection at an earlier stage is needed. (2)
Small
intestinal
adenocarcinoma
patients with an adenomatous component had a better survival than those without an adenomatous component. (3) Lymph node metastasis and distal location (jejunum and ileum) of tumor are the most important independent prognostic factors.
[MeSH-major]
Adenocarcinoma
/ pathology. Duodenal Neoplasms / pathology. Ileal Neoplasms / pathology. Jejunal Neoplasms / pathology
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Female. Humans.
Intestine
,
Small
/ pathology. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Prognosis
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[Copyright]
2010 Elsevier Inc. All rights reserved.
(PMID = 20334897.001).
[ISSN]
1532-8392
[Journal-full-title]
Human pathology
[ISO-abbreviation]
Hum. Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
20.
Hong SH, Koh YH, Rho SY, Byun JH, Oh ST, Im KW, Kim EK, Chang SK:
Primary adenocarcinoma of the small intestine: presentation, prognostic factors and clinical outcome.
Jpn J Clin Oncol
; 2009 Jan;39(1):54-61
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[Title]
Primary
adenocarcinoma of
the
small intestine
: presentation, prognostic factors and clinical outcome.
BACKGROUND: Malignant
small intestine
tumor accounts for 0.1-0.3% of all malignancies.
Although primary
adenocarcinoma
is the most common histologic subtype, there is no report of the clinical characteristics and natural history in the Asian population.
METHODS: We conducted retrospective analysis for the patients with the
small intestine adenocarcinoma
to explore the clinical characteristics and prognosis.
All patients with
adenocarcinoma of small intestine
diagnosed between March 1997 and March 2007 in the Catholic Medical Center in Korea were identified through the cancer registry.
CONCLUSIONS: The prognosis of primary
adenocarcinoma of small intestine
was poor, especially in cases where curative resection could not to be performed.
[MeSH-major]
Adenocarcinoma
/ pathology.
Intestinal
Neoplasms / pathology.
Intestine
,
Small
/ pathology
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Female. Humans. Korea. Male. Middle Aged. Neoplasm Recurrence, Local /
diagnosis
. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome
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(PMID = 18997182.001).
[ISSN]
1465-3621
[Journal-full-title]
Japanese journal of clinical oncology
[ISO-abbreviation]
Jpn. J. Clin. Oncol.
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study
[Publication-country]
England
21.
Fishman PN, Pond GR, Moore MJ, Oza A, Burkes RL, Siu LL, Feld R, Gallinger S, Greig P, Knox JJ:
Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases.
Am J Clin Oncol
; 2006 Jun;29(3):225-31
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[Title]
Natural history and chemotherapy effectiveness for advanced
adenocarcinoma of
the
small
bowel
: a retrospective review of 113 cases.
BACKGROUND:
Small
bowel
adenocarcinoma
is a rare cancer that has generally been considered resistant to chemotherapy, although little has been published on the role of chemotherapy.
A retrospective analysis was conducted of patients with advanced
small
bowel
adenocarcinoma
to explore chemotherapy use, and gain knowledge for ongoing management and future clinical trials.
PATIENTS AND METHODS: All patients with advanced
adenocarcinoma of
the
small
bowel
treated at Princess Margaret Hospital (PMH) between 1986 and 2004 were identified through the cancer registry.
CONCLUSION: Chemotherapy appears to have activity in
adenocarcinoma of
the
small
bowel
.
[MeSH-major]
Adenocarcinoma
/ drug therapy.
Adenocarcinoma
/ pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Intestinal
Neoplasms / drug therapy.
Intestinal
Neoplasms / pathology
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(PMID = 16755174.001).
[ISSN]
1537-453X
[Journal-full-title]
American journal of clinical oncology
[ISO-abbreviation]
Am. J. Clin. Oncol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
22.
Kalogerinis PT, Poulos JE, Morfesis A, Daniels A, Georgakila S, Daignualt T, Georgakilas AG:
Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective.
BMC Gastroenterol
; 2010;10:109
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BACKGROUND: There is very
small
occurrence
of adenocarcinoma
in the
small
bowel
.
We present a case of primary duodenal
adenocarcinoma
and discuss the findings of the case diagnostic modalities, current knowledge on the molecular biology behind
small
bowel
neoplasms and treatment options.
CASE: The patient had a history of iron deficiency anemia and occult bleeding with extensive workup consisting of upper endoscopy, colonoscopy, capsule endoscopy, upper gastrointestinal series with
small
bowel
follow through and push enteroscopy.
Due to persistent abdominal pain and iron deficiency anemia the patient underwent push enteroscopy which revealed
adenocarcinoma of
the duodenum.
The patient underwent en-bloc duodenectomy which revealed T3N1M0
adenocarcinoma of
the 4th portion of the duodenum.
CONCLUSIONS: Primary duodenal carcinoma, although rare should be considered in the differential
diagnosis
of occult gastrointestinal bleeding when evaluation of the lower and upper GI tract is unremarkable.
We discuss the current evaluation and management of this
small
bowel
neoplasm.
[MeSH-major]
Adenocarcinoma
/
diagnosis
. Biomarkers, Tumor / analysis. Duodenal Neoplasms /
diagnosis
[MeSH-minor]
Aged.
Diagnosis
, Differential. Duodenoscopy. Female. Humans. Laparotomy. Ligaments. Tomography, X-Ray Computed
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(PMID = 20849628.001).
[ISSN]
1471-230X
[Journal-full-title]
BMC gastroenterology
[ISO-abbreviation]
BMC Gastroenterol
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor
[Other-IDs]
NLM/ PMC2949773
23.
Overman MJ, Hu CY, Wolff RA, Chang GJ:
Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database.
Cancer
; 2010 Dec 1;116(23):5374-82
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[Title]
Prognostic value of lymph node evaluation in
small
bowel
adenocarcinoma
: analysis of the surveillance, epidemiology, and end results database.
BACKGROUND: The presence of distant metastases and the completeness of resection are important prognostic factors in patients with
small
bowel
adenocarcinoma
(SBA); however, the influence of lymph node metastasis on patient outcome has not been well characterized.
[MeSH-major]
Adenocarcinoma
/ pathology.
Intestinal
Neoplasms / pathology.
Intestine
,
Small
. Lymph Nodes / pathology
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[Copyright]
Copyright © 2010 American Cancer Society.
(PMID = 20715162.001).
[ISSN]
0008-543X
[Journal-full-title]
Cancer
[ISO-abbreviation]
Cancer
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
24.
Aurello P, Dente M, D'Angelo F, Nigri G, Cescon M, Ramacciato G:
Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient.
Am Surg
; 2009 Feb;75(2):189-90
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[Title]
Intestinal
occlusion resulting from a
small
bowel
adenocarcinoma
as first onset of Crohn's disease in a healthy patient.
[MeSH-major]
Adenocarcinoma
/ pathology. Crohn Disease / etiology. Ileal Neoplasms / pathology.
Intestinal
Obstruction / etiology
Genetic Alliance.
consumer health - Crohn Disease
.
MedlinePlus Health Information.
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.
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.
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.
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(PMID = 19280822.001).
[ISSN]
0003-1348
[Journal-full-title]
The American surgeon
[ISO-abbreviation]
Am Surg
[Language]
eng
[Publication-type]
Case Reports; Letter
[Publication-country]
United States
25.
Catassi C, Bearzi I, Holmes GK:
Association of celiac disease and intestinal lymphomas and other cancers.
Gastroenterology
; 2005 Apr;128(4 Suppl 1):S79-86
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[Title]
Association of celiac disease and
intestinal
lymphomas and other cancers.
Celiac disease (CD) is associated with
intestinal
lymphoma and other forms of cancer, especially
adenocarcinoma of
the
small intestine
, of the pharynx, and of the esophagus.
Enteropathy-associated T-cell lymphoma (EATL) is a rare form of high-grade, T-cell non-Hodgkin lymphoma (NHL) of the upper
small intestine
that is specifically associated with CD.
EATL derives from a clonal proliferation of intraepithelial lymphocytes and is often disseminated at
diagnosis
.
[MeSH-major]
Adenocarcinoma
/ etiology. Celiac Disease / complications. Gastrointestinal Neoplasms / etiology.
Intestinal
Neoplasms / etiology. Lymphoma, T-Cell / etiology
Genetic Alliance.
consumer health - Celiac Disease
.
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.
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.
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(PMID = 15825131.001).
[ISSN]
0016-5085
[Journal-full-title]
Gastroenterology
[ISO-abbreviation]
Gastroenterology
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
8002-80-0 / Glutens
[Number-of-references]
40
26.
Yamada K, Ikehara Y, Nakanishi H, Kozawa E, Tatematsu M, Sugiura H:
Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma.
J Orthop Sci
; 2007 Nov;12(6):606-10
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[Title]
Solitary bone metastasis as the first clinical manifestation in a patient with
small
bowel
adenocarcinoma
.
[MeSH-major]
Acetabulum.
Adenocarcinoma
/ secondary. Bone Neoplasms / secondary. Jejunal Neoplasms / pathology
[MeSH-minor]
Adult. Biopsy.
Diagnosis
, Differential. Fatal Outcome. Humans. Male. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed
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(PMID = 18040646.001).
[ISSN]
0949-2658
[Journal-full-title]
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
[ISO-abbreviation]
J Orthop Sci
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
27.
Stratopoulos C, Papakonstantinou A, Anagnostopoulos G, Terzis I, Tzimas G, Gourgiotis S, Vamvouka C, Hadjiyannakis E:
Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study.
Eur J Cancer Care (Engl)
; 2009 Sep;18(5):466-9
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[Title]
Intestinal
neurofibromatosis and
small
-
bowel
adenocarcinoma
: a single case study.
However, the coexistence of neurofibromatosis with
small
-
bowel
adenocarcinoma
is exceedingly rare.
We present an uncommon case of neurofibromatosis type 1, involving the
small
bowel
in a 73-year-old man, who was admitted to our department with signs of acute abdomen.
These nodules obstructed ileal lumen, while the
intestine
wall was perforated in one point.
Histology revealed neurofibromatosis type 1 with malignant transformation to
small
-
bowel
adenocarcinoma
.
We suggest that
adenocarcinoma of small
bowel
should be considered in the evaluation of acute abdominal pain in neurofibromatosis patients.
[MeSH-major]
Adenocarcinoma
/ pathology. Ileal Neoplasms / pathology.
Intestine
,
Small
/ pathology. Neoplasms, Multiple Primary / pathology. Neurofibromatosis 1 / pathology
[MeSH-minor]
Abdomen, Acute / etiology. Aged. Follow-Up Studies. Humans.
Intestinal
Obstruction / etiology.
Intestinal
Obstruction / pathology. Male. Tomography, X-Ray Computed
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(PMID = 19473375.001).
[ISSN]
1365-2354
[Journal-full-title]
European journal of cancer care
[ISO-abbreviation]
Eur J Cancer Care (Engl)
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
England
28.
Saurin JC, Pilleul F, Soussan EB, Manière T, D'Halluin PN, Gaudric M, Cellier C, Heresbach D, Gaudin JL, Capsule Commission of the French Society of Digestive Endoscopy (SFED):
Small-bowel capsule endoscopy diagnoses early and advanced neoplasms in asymptomatic patients with Lynch syndrome.
Endoscopy
; 2010 Dec;42(12):1057-62
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[Title]
Small
-
bowel
capsule endoscopy diagnoses early and advanced neoplasms in asymptomatic patients with Lynch syndrome.
BACKGROUND AND STUDY AIMS: Patients with Lynch syndrome are at increased risk of developing
small
-
bowel
adenocarcinoma
, which usually has a bad prognosis and needs to be diagnosed early.
RESULTS: Histologically confirmed
small
-
bowel
neoplasms were diagnosed in three patients (8.6 %): one
adenocarcinoma
(T3N0M0) and two adenomas with low-grade dysplasia.
CT enteroclysis raised suspicion of one neoplasm (
adenocarcinoma
) but missed the two others.
The clinical usefulness of systematic
small
-
bowel
screening in these patients should be confirmed through large prospective studies.
[MeSH-major]
Adenocarcinoma
/
diagnosis
. Adenoma /
diagnosis
. Capsule Endoscopy. Colorectal Neoplasms, Hereditary Nonpolyposis / complications.
Intestinal
Neoplasms /
diagnosis
.
Intestine
,
Small
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[Copyright]
© Georg Thieme Verlag KG Stuttgart · New York.
(PMID = 20821360.001).
[ISSN]
1438-8812
[Journal-full-title]
Endoscopy
[ISO-abbreviation]
Endoscopy
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Contrast Media
29.
Triantafillidis JK, Nasioulas G, Kosmidis PA:
Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.
Anticancer Res
; 2009 Jul;29(7):2727-37
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[Title]
Colorectal cancer and inflammatory
bowel
disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.
Patients with long-standing ulcerative colitis and Crohn's disease have an increased risk of developing colorectal cancer and patients with
small
intestinal
Crohn's disease are at increased risk
of small
bowel
adenocarcinoma
.
Colorectal cancer appearing on the ground of inflammatory
bowel
disease is the result of a process which is believed to begin from no dysplasia progressing to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive
adenocarcinoma
, although colorectal cancer can arise without proceeding through each of these steps.
[MeSH-major]
Cell Transformation, Neoplastic. Colorectal Neoplasms / epidemiology. Inflammatory
Bowel
Diseases / epidemiology
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Cited by Patents in
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(PMID = 19596953.001).
[ISSN]
1791-7530
[Journal-full-title]
Anticancer research
[ISO-abbreviation]
Anticancer Res.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Greece
[Number-of-references]
94
30.
Patel S, Liu D, Caron P, Seiter K:
Acute myelogenous leukemia following irinotecan-based chemotherapy for adenocarcinoma of the small intestine.
Leuk Lymphoma
; 2007 May;48(5):1032-3
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[Title]
Acute myelogenous leukemia following irinotecan-based chemotherapy for
adenocarcinoma of
the
small intestine
.
[MeSH-major]
Adenocarcinoma
/ drug therapy. Camptothecin / analogs & derivatives.
Intestinal
Neoplasms / drug therapy.
Intestine
,
Small
/ pathology. Leukemia, Myeloid, Acute / drug therapy
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.
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.
Hazardous Substances Data Bank.
FLUOROURACIL
.
Hazardous Substances Data Bank.
LEUCOVORIN
.
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(PMID = 17487750.001).
[ISSN]
1042-8194
[Journal-full-title]
Leukemia & lymphoma
[ISO-abbreviation]
Leuk. Lymphoma
[Language]
eng
[Publication-type]
Case Reports; Letter
[Publication-country]
England
[Chemical-registry-number]
7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; IFL protocol
31.
Farrell S, Gray SB, Best BG:
Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature.
Int Surg
; 2005 Apr-Jun;90(2):85-7
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[Title]
Mucusuria--an unusual manifestation of ileal
adenocarcinoma
: a case report and review of the literature.
Primary
adenocarcinoma of
the ileum is an uncommon gastrointestinal malignancy, the symptoms of which are often insidious in onset.
This case history highlights the previously unreported finding of ileal
adenocarcinoma
presenting with mucusuria, caused by local invasion of the bladder in a 44-year-old male.
A review of the literature is included to highlight the incidence, risk factors, clinical presentation, investigation, and current management
of adenocarcinoma
of the
small
bowel
.
[MeSH-major]
Adenocarcinoma
/ secondary. Ileal Neoplasms / pathology.
Intestinal
Fistula /
diagnosis
. Urinary Bladder Fistula /
diagnosis
. Urinary Bladder Neoplasms / secondary
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(PMID = 16119711.001).
[ISSN]
0020-8868
[Journal-full-title]
International surgery
[ISO-abbreviation]
Int Surg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Italy
32.
Bruckner HW, Hrehorovich VR, Sawhney HS, Meeus SI, Coopeman AM:
Chemotherapeutic management of small bowel adenocarcinoma associated with Crohn's disease.
J Chemother
; 2006 Oct;18(5):545-8
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[Title]
Chemotherapeutic management
of small
bowel
adenocarcinoma
associated with Crohn's disease.
Four patients with metastatic primary
small
bowel
adenocarcinoma
associated with Crohn's disease were successfully treated with low dose combination chemotherapy consisting of 5-fluorouracil, leucovorin and irinotecan with or without gemcitabine.
[MeSH-major]
Adenocarcinoma
/ drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Crohn Disease / complications. Duodenal Neoplasms / drug therapy. Ileal Neoplasms / drug therapy. Jejunal Neoplasms / drug therapy
[MeSH-minor]
Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Female. Humans.
Intestine
,
Small
/ pathology. Leucovorin / administration & dosage. Male. Remission Induction. Survival Analysis
Genetic Alliance.
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.
MedlinePlus Health Information.
consumer health - Crohn's Disease
.
MedlinePlus Health Information.
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.
Hazardous Substances Data Bank.
LEUCOVORIN
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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(PMID = 17127233.001).
[ISSN]
1120-009X
[Journal-full-title]
Journal of chemotherapy (Florence, Italy)
[ISO-abbreviation]
J Chemother
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Italy
[Chemical-registry-number]
7673326042 / irinotecan; Q573I9DVLP / Leucovorin; XT3Z54Z28A / Camptothecin
33.
Prodinger PM, Sarbia M, Massmann J, Straka C, Meyer G, Steinlein OK:
Gorlin syndrome associated with small bowel carcinoma and mesenchymal proliferation of the gastrointestinal tract: case report and review of literature.
BMC Cancer
; 2010;10:360
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[Title]
Gorlin syndrome associated with
small
bowel
carcinoma and mesenchymal proliferation of the gastrointestinal tract: case report and review of literature.
BACKGROUND AND CASE PRESENTATION: A patient with nevoid basal cell carcinoma syndrome (Gorlin syndrome) presented with two unusual clinical features, i.e.
adenocarcinoma of
the
small
bowel
and extensive mesenchymal proliferation of the lower gastrointestinal tract.
[MeSH-major]
Basal Cell Nevus Syndrome / pathology. Cell Proliferation. Gastrointestinal Tract / pathology.
Intestinal
Neoplasms / pathology.
Intestine
,
Small
/ pathology. Mesoderm / pathology
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[Cites]
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1471-2407
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BMC cancer
[ISO-abbreviation]
BMC Cancer
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Receptors, Cell Surface; 0 / patched receptors
[Other-IDs]
NLM/ PMC2912266
34.
Munday JS, Keenan JI, Beaugie CR, Sugiarto H:
Ovine small intestinal adenocarcinomas are not associated with infection by herpesviruses, Helicobacter species or Mycobacterium avium subspecies paratuberculosis.
J Comp Pathol
; 2009 Feb-Apr;140(2-3):177-81
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[Title]
Ovine
small
intestinal adenocarcinomas
are not associated with infection by herpesviruses, Helicobacter species or Mycobacterium avium subspecies paratuberculosis.
Sheep in New Zealand more frequently develop
small
intestinal
adenocarcinoma
(SIA) than sheep in other countries.
The reasons for this high rate of
intestinal
neoplasia are not known.
This study compared rates of detection of herpesviruses, Helicobacter species, and Mycobacterium avium subspecies paratuberculosis (MAP) in ovine SIA to rates of detection in samples
of intestine
with non-neoplastic disease.
These infectious agents were chosen as all three have been associated with human
intestinal
cancer.
[MeSH-major]
Adenocarcinoma
/ microbiology.
Intestinal
Neoplasms / microbiology. Sheep Diseases / microbiology
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(PMID = 19159897.001).
[ISSN]
1532-3129
[Journal-full-title]
Journal of comparative pathology
[ISO-abbreviation]
J. Comp. Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / DNA, Bacterial
35.
Shenderey RL, Thompson N, Mansfield JC, Rees C:
Adenocarcinoma as a complication of small bowel Crohn's disease.
Eur J Gastroenterol Hepatol
; 2005 Nov;17(11):1255-7
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[Title]
Adenocarcinoma
as a complication
of small
bowel
Crohn's disease.
Carcinoma is a recognized but rare complication
of small
bowel
Crohn's disease.
This case series emphasizes the importance of considering this
diagnosis
in patients with
small
bowel
Crohn's disease.
We report three cases in which patients were treated for presumed exacerbations of Crohn's, but were subsequently found to have underlying
small
bowel
adenocarcinoma
.
[MeSH-major]
Adenocarcinoma
/ etiology. Crohn Disease / complications. Ileal Neoplasms / etiology. Jejunal Neoplasms / etiology
[MeSH-minor]
Adult. Fatal Outcome. Humans.
Intestinal
Obstruction / etiology. Male. Middle Aged. Tomography, X-Ray Computed
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.
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.
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(PMID = 16215441.001).
[ISSN]
0954-691X
[Journal-full-title]
European journal of gastroenterology & hepatology
[ISO-abbreviation]
Eur J Gastroenterol Hepatol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
England
36.
Xie J, Itzkowitz SH:
Cancer in inflammatory bowel disease.
World J Gastroenterol
; 2008 Jan 21;14(3):378-89
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[Title]
Cancer in inflammatory
bowel
disease.
Patients with long-standing inflammatory
bowel
disease (IBD) have an increased risk of developing colorectal cancer (CRC).
Colon cancer risk in inflammatory
bowel
disease increases with longer duration of colitis, greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of
the bowel
.
Patients with
small
intestinal
Crohn's disease are at increased risk
of small
bowel
adenocarcinoma
.
Other extra
intestinal
cancers, such as hepatobiliary and hematopoietic cancer, have shown variable incidence rates.
[MeSH-major]
Colorectal Neoplasms / physiopathology. Inflammatory
Bowel
Diseases / physiopathology. Neoplasms / physiopathology
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(PMID = 18200660.001).
[ISSN]
1007-9327
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
China
[Number-of-references]
118
[Other-IDs]
NLM/ PMC2679126
37.
Suenaga M, Mizunuma N, Chin K, Matsusaka S, Shinozaki E, Oya M, Ueno M, Yamaguchi T, Muto T, Konishi F, Hatake K:
Chemotherapy for small-bowel Adenocarcinoma at a single institution.
Surg Today
; 2009;39(1):27-31
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[Title]
Chemotherapy for
small
-
bowel
Adenocarcinoma
at a single institution.
PURPOSE:
Small
-
bowel
adenocarcinoma
(SBA) is rare.
[MeSH-major]
Adenocarcinoma
/ drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Intestinal
Neoplasms / drug therapy
[MeSH-minor]
Adult. Aged. Camptothecin / administration & dosage. Camptothecin / adverse effects. Camptothecin / analogs & derivatives. Disease Progression. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Follow-Up Studies. Humans.
Intestine
,
Small
/ diagnostic imaging. Leucovorin / administration & dosage. Leucovorin / adverse effects. Male. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed. Vitamin B Complex / administration & dosage. Vitamin B Complex / adverse effects
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FLUOROURACIL
.
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LEUCOVORIN
.
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(PMID = 19132464.001).
[ISSN]
0941-1291
[Journal-full-title]
Surgery today
[ISO-abbreviation]
Surg. Today
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0H43101T0J / irinotecan; 12001-76-2 / Vitamin B Complex; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
38.
Zhang MQ, Chen ZM, Wang HL:
Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma.
Mod Pathol
; 2006 Apr;19(4):573-80
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[Title]
Immunohistochemical investigation of tumorigenic pathways in
small
intestinal
adenocarcinoma
: a comparison with colorectal
adenocarcinoma
.
Small
intestinal
adenocarcinoma
is an uncommon neoplasm morphologically similar to or indistinguishable from colorectal
adenocarcinoma
.
Although much has been learned about genetic pathways critical to colorectal tumorigenesis, little is known about molecular alterations involved in the development
of small
intestinal
adenocarcinoma
.
In this study, we immunohistochemically compared non-ampullary
small
intestinal adenocarcinomas
with sporadic colorectal
adenocarcinomas
for the expression of several proteins known to serve pivotal roles in colorectal tumorigenesis.
The results show that complete loss of adenomatous polyposis coli immunoreactivity, presumably resulting from its gene mutations, was observed in eight of 26 (31%)
small
intestinal adenocarcinomas
and 36 of 51 (71%) colorectal
adenocarcinomas
(P = 0.0008).
Nuclear localization of beta-catenin, an indirect evidence of deregulated Wnt signaling pathway, was observed in 5 (19%)
small
intestinal adenocarcinomas
and 36 (71%) colorectal
adenocarcinomas
(P<0.0001).
Total lack of nuclear staining for one or more of the DNA mismatch repair enzymes occurred in a similar low frequency in both
small
intestinal
and colorectal
adenocarcinomas
, seen in two of 25 (8%) and 10 of 47 (21%) cases, respectively (P = 0.1958).
The frequencies of aberrant p53 and RB expression were also similar between
small
intestinal
and colorectal
adenocarcinomas
.
These observations indicate that defects in the Wnt and microsatellite instability pathways occur in over 90% of colorectal
adenocarcinomas
, but in only 40%
of small
intestinal adenocarcinomas
.
Small
intestinal
tumorigenesis appears to follow a distinct, yet unidentified, molecular pathway(s) from its colorectal counterpart despite their morphologic similarity.
[MeSH-major]
Adenocarcinoma
/ pathology. Colorectal Neoplasms / pathology.
Intestinal
Neoplasms / pathology.
Intestine
,
Small
/ pathology
MedlinePlus Health Information.
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(PMID = 16501564.001).
[ISSN]
0893-3952
[Journal-full-title]
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
[ISO-abbreviation]
Mod. Pathol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Retinoblastoma Protein; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
39.
von Rahden BH, Langner C, Brücher BL, Stein HJ, Sarbia M:
No association of primary adenocarcinomas of the small bowel with Epstein-Barr virus infection.
Mol Carcinog
; 2006 May;45(5):349-52
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[Title]
No association of primary
adenocarcinomas
of the
small
bowel
with Epstein-Barr virus infection.
Adenocarcinomas
of the
small
bowel
comprise a very rare entity, with little knowledge about molecular properties and etiological aspects.
We have investigated the prevalence of EBER expression (EBV-encoded
small
RNAs) in a series
of small
bowel adenocarcinomas
(n=56) utilizing RNA in situ hybridization (EBER-RISH).
A surgical series of 82 primary resected gastric (n=36) or cardiac (n=46)
adenocarcinomas
(TU Munich) was used as control group.
None of the 56
small
bowel
carcinomas exhibited EBER expression whereas in the control group the rate of EBER expression accounted for 4.4% in the group of cardia carcinomas and 8.6% in the group of gastric cancers.
These results indicate that EBV infection plays no etiologic role in primary
small
bowel adenocarcinomas
.
[MeSH-major]
Adenocarcinoma
/ virology. Epstein-Barr Virus Infections / virology. Herpesvirus 4, Human / genetics.
Intestinal
Neoplasms / virology.
Intestine
,
Small
/ virology. Stomach Neoplasms / virology
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.
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.
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[Copyright]
(c) 2006 Wiley-Liss, Inc.
(PMID = 16493667.001).
[ISSN]
0899-1987
[Journal-full-title]
Molecular carcinogenesis
[ISO-abbreviation]
Mol. Carcinog.
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study
[Publication-country]
United States
[Chemical-registry-number]
0 / RNA, Viral
40.
Sasaki Y, Natsuizaka M, Takano M, Suzuki M, Tsuyuguchi M, Nagasako T, Kawamura N, Kudo M, Tsuda I, Meguro J:
[A case of primary adenocarcinoma of small intestine with multiple liver metastases successfully treated with mFOLFOX6].
Gan To Kagaku Ryoho
; 2009 Nov;36(11):1927-9
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[Title]
[A case of primary
adenocarcinoma of small intestine
with multiple liver metastases successfully treated with mFOLFOX6].
Biopsy of the tumor was performed and pathological examination revealed
adenocarcinoma
.
Histopathological examination revealed moderately-differentiated
adenocarcinoma of
Bauhin's valve and the terminal ileum, and no
adenocarcinoma
was found in the cecum and ascending colon.
He was diagnosed with primary
adenocarcinoma of
the ileum with multiple liver metastases.
Effectiveness of mFOLFOX6 for primary
adenocarcinoma of small intestine
is suggested.
[MeSH-major]
Adenocarcinoma
/ pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Ileal Neoplasms / pathology. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary
MedlinePlus Health Information.
consumer health - Intestinal Cancer
.
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consumer health - Liver Cancer
.
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.
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.
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(PMID = 19920403.001).
[ISSN]
0385-0684
[Journal-full-title]
Gan to kagaku ryoho. Cancer & chemotherapy
[ISO-abbreviation]
Gan To Kagaku Ryoho
[Language]
jpn
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
41.
Garrido A, Luque A, Vázquez A, Hernández JM, Alcántara F, Márquez JL:
[Primary small bowel neoplasms as a complication of celiac disease].
Gastroenterol Hepatol
; 2009 Nov;32(9):618-21
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[Title]
[Primary
small
bowel
neoplasms as a complication of celiac disease].
[Transliterated title]
Neoplasias primarias
de intestino delgado
como complicación
de
la enfermedad celíaca.
The most serious complication in these patients is the development of neoplasms, the most frequent being enteropathy-associated T-cell lymphoma; however, an increase in the incidence
of small
bowel
adenocarcinoma
has also been described.
We present two cases
of small
bowel
carcinoma in patients with celiac disease, which were diagnosed at the onset of the disease.
[MeSH-major]
Adenocarcinoma
/ etiology. Celiac Disease / complications. Duodenal Neoplasms / etiology. Ileal Neoplasms / etiology
Genetic Alliance.
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.
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consumer health - Celiac Disease
.
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(PMID = 19625106.001).
[ISSN]
0210-5705
[Journal-full-title]
Gastroenterología y hepatología
[ISO-abbreviation]
Gastroenterol Hepatol
[Language]
spa
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Spain
42.
Terado Y, Kurata A, Ishida T, Imamura T, Sakamoto A:
Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma.
Pathol Int
; 2010 Oct;60(10):701-5
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[Title]
Adenocarcinoma of small
intestinal
type in retroperitoneal mature teratoma.
We report a case
of small
intestinal
type
adenocarcinoma
arising in retroperitoneal mature cystic teratoma in a young male.
Adenocarcinoma
without stromal invasion was observed adjacent to the
small
intestinal
mucosa.
Immunohistochemistry of the
adenocarcinoma
tissue revealed p53 overexpression and high Ki-67 labeling index as well as positive staining for CD10, cytokeratin 7, and cytokeratin 20.
Therefore,
the diagnosis
of small
intestinal
adenocarcinoma
was made.
To our knowledge, this is the first case
of small
intestinal
adenocarcinoma
arising in retroperitoneal mature cystic teratoma.
A unique feature of this case is that malignant transformation in retroperitoneal mature teratoma arose even in the fully developed
intestine
.
[MeSH-major]
Adenocarcinoma
/ pathology. Neoplasms, Multiple Primary / pathology. Retroperitoneal Neoplasms / pathology. Teratoma / pathology
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[Copyright]
© 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
[ErratumIn]
Pathol Int. 2010 Dec;60(12):798
(PMID = 20846270.001).
[ISSN]
1440-1827
[Journal-full-title]
Pathology international
[ISO-abbreviation]
Pathol. Int.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Australia
43.
Krishnamurthy P, Varghese SE, Gopalswamy N, Hillman N, Ali SA:
Small-bowel adenocarcinoma: case report and review of literature on diagnosis of small-bowel tumors.
Gastroenterol Hepatol (N Y)
; 2007 Feb;3(2):129-35
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[Title]
Small
-
bowel
adenocarcinoma
: case report and review of literature on
diagnosis
of small
-
bowel
tumors.
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[Cites]
Gastrointest Endosc. 1995 May;41(5):524-5
[
7615240.001
]
[Cites]
Am J Gastroenterol. 1994 May;89(5):699-701
[
8172140.001
]
[Cites]
Clin Radiol. 1993 Jan;47(1):46-8
[
8428417.001
]
(PMID = 21960822.001).
[ISSN]
1554-7914
[Journal-full-title]
Gastroenterology & hepatology
[ISO-abbreviation]
Gastroenterol Hepatol (N Y)
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ PMC3099353
44.
Lingohr P, Knoefel WT, Kleimann E, Rheinwalt KP:
[Laparoscopic coincidental finding in a case of incomplete ileus: adenocarcinoma of the small intestine as first manifestation of Crohn's disease].
Zentralbl Chir
; 2007 Dec;132(6):564-8
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[Title]
[Laparoscopic coincidental finding in a case of incomplete ileus:
adenocarcinoma of
the
small intestine
as first manifestation of Crohn's disease].
[Transliterated title]
Laparoskopischer Zufallsbefund bei inkomplettem Ileus:
Adenokarzinom des
Dünndarms als Erstmanifestation eines Morbus Crohn.
The case-study reminds
of adenocarcinoma
of the
small intestine
as a rare complication of Crohn's disease.
Epidemiological studies concerning
small
bowel
carcinoma showed consumption of sugar and carbohydrates as pathogenetic factors, other conditions like ileostoma, ileumconduit, Crohn's disease and coeliac disease have been identified to some extent.
An adenoma-carcinoma sequence as in large
intestine
carcinoma has been discussed.
Diagnosis
of early stages
of adenocarcinoma
of the
small intestine
is very difficult and thus might be impossible to differentiate from exacerbation or progressive stenosis of preexisting Crohn's disease.
If non-invasive diagnostic measures (ultrasound,
small
bowel
enema, CT-scan, intestinoscopy, radiography, NMR-Sellink, capsule-endoscopy) fail to clear the situation a diagnostic laparoscopy or even laparotomy should not be delayed.
[MeSH-major]
Adenocarcinoma
/ surgery. Crohn Disease / surgery. Ileal Neoplasms / surgery. Ileus / surgery. Incidental Findings. Laparoscopy
[MeSH-minor]
Aged. Appendectomy. Cell Transformation, Neoplastic / pathology. Cholecystectomy, Laparoscopic. Cholelithiasis /
diagnosis
. Cholelithiasis / surgery.
Diagnosis
, Differential. Female. Humans. Ileum / pathology. Ileum / surgery.
Intestinal
Mucosa / pathology.
Intestinal
Mucosa / surgery. Neoplasm Invasiveness
Genetic Alliance.
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.
MedlinePlus Health Information.
consumer health - Crohn's Disease
.
MedlinePlus Health Information.
consumer health - Intestinal Cancer
.
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(PMID = 18098087.001).
[ISSN]
0044-409X
[Journal-full-title]
Zentralblatt für Chirurgie
[ISO-abbreviation]
Zentralbl Chir
[Language]
ger
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Germany
45.
Chua TC, Koh JL, Yan TD, Liauw W, Morris DL:
Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma.
J Surg Oncol
; 2009 Aug 1;100(2):139-43
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[Title]
Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from
small
bowel
adenocarcinoma
.
BACKGROUND:
Small
bowel
adenocarcinoma
is a rare malignancy that presents both a diagnostic and therapeutic challenge.
We review our experience with
small
bowel
peritoneal carcinomatosis following treatment with cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC).
METHODS: From a prospective database of CRS and PIC, seven patients were identified to have undergone treatment for
small
bowel
peritoneal carcinomatosis with CRS and hyperthermic intraperitoneal chemotherapy (Mitomycin C) and early postoperative intraperitoneal chemotherapy (5FU).
Tumor histology of poorly differentiated
adenocarcinoma
with signet ring, lymphovascular invasion and perineural invasion appeared to be associated with a poor outcome.
CONCLUSION: Cytoreductive surgery and perioperative intraperitoneal chemotherapy is a treatment option for
small
bowel
cancer peritoneal carcinomatosis with encouraging survival results.
[MeSH-major]
Adenocarcinoma
/ therapy. Hyperthermia, Induced. Ileal Neoplasms / therapy. Jejunal Neoplasms / therapy
MedlinePlus Health Information.
consumer health - Intestinal Cancer
.
The Lens.
Cited by Patents in
.
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(PMID = 19544356.001).
[ISSN]
1096-9098
[Journal-full-title]
Journal of surgical oncology
[ISO-abbreviation]
J Surg Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
46.
Gibson MK, Holcroft CA, Kvols LK, Haller D:
Phase II study of 5-fluorouracil, doxorubicin, and mitomycin C for metastatic small bowel adenocarcinoma.
Oncologist
; 2005 Feb;10(2):132-7
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[Title]
Phase II study of 5-fluorouracil, doxorubicin, and mitomycin C for metastatic
small
bowel
adenocarcinoma
.
BACKGROUND:
Small
bowel
adenocarcinoma
is a rare gastrointestinal malignancy that is treated primarily with surgery.
This study aimed to document the response rate and survival time for patients with advanced
small
bowel
adenocarcinoma
who were not surgically curable and were treated with a regimen of 5-fluorouracil (5-FU), mitomycin C (Mutamycin; Bristol-Myers Squibb; Princeton, NJ), and doxorubicin (Adriamycin; Bedford Laboratories; Bedford, OH), the FAM regimen.
CONCLUSIONS: The FAM regimen was active and tolerable for patients with advanced
small
bowel
adenocarcinoma
; however, the results were no better than those seen with other chemotherapy combinations.
[MeSH-major]
Adenocarcinoma
/ drug therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy
MedlinePlus Health Information.
consumer health - Intestinal Cancer
.
COS Scholar Universe.
author profiles
.
Hazardous Substances Data Bank.
DOXORUBICIN
.
Hazardous Substances Data Bank.
MITOMYCIN C
.
Hazardous Substances Data Bank.
FLUOROURACIL
.
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(PMID = 15709215.001).
[ISSN]
1083-7159
[Journal-full-title]
The oncologist
[ISO-abbreviation]
Oncologist
[Language]
eng
[Publication-type]
Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study
[Publication-country]
United States
[Chemical-registry-number]
50SG953SK6 / Mitomycin; 80168379AG / Doxorubicin; U3P01618RT / Fluorouracil
47.
Jacks SP, Hundley JC, Shen P, Russell GB, Levine EA:
Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma.
J Surg Oncol
; 2005 Aug 1;91(2):112-7; discussion 118-9
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[Title]
Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis from
small
bowel
adenocarcinoma
.
Small
bowel
adenocarcinoma
is a rare etiology for PC.
METHODS: From a prospective database of IPHC patients, six patients diagnosed with PC from
adenocarcinoma of
the
small
bowel
were identified.
Median survival after
diagnosis
of small
bowel
adenocarcinoma
was 54 months, while median survival after CS and IPHC for PC was 30.1 months.
CONCLUSIONS:
Small
bowel
adenocarcinoma
with PC remains an unusual therapeutic challenge.
[MeSH-major]
Adenocarcinoma
/ drug therapy. Hyperthermia, Induced. Ileal Neoplasms / drug therapy. Jejunal Neoplasms / drug therapy. Peritoneal Neoplasms / drug therapy
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[Copyright]
Copyright 2005 Wiley-Liss, Inc.
(PMID = 16028284.001).
[ISSN]
0022-4790
[Journal-full-title]
Journal of surgical oncology
[ISO-abbreviation]
J Surg Oncol
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
48.
Ross A, Mehdizadeh S, Tokar J, Leighton JA, Kamal A, Chen A, Schembre D, Chen G, Binmoeller K, Kozarek R, Waxman I, Dye C, Gerson L, Harrison ME, Haluszka O, Lo S, Semrad C:
Double balloon enteroscopy detects small bowel mass lesions missed by capsule endoscopy.
Dig Dis Sci
; 2008 Aug;53(8):2140-3
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[Title]
Double balloon enteroscopy detects
small
bowel
mass lesions missed by capsule endoscopy.
BACKGROUND:
Small
bowel
mass lesions (SBML) are a relatively common cause of obscure gastrointestinal bleeding (OGIB).
Their detection has been limited by the inability to endoscopically examine the entire
small intestine
.
A
small
bowel
mass lesion was identified in 18 patients.
Capsule endoscopy failed to identify all four cases of primary
small
bowel
adenocarcinoma
.
CONCLUSIONS: Double balloon enteroscopy detects
small
bowel
mass lesions responsible for OGIB that are missed by CE.
Additional endoscopic evaluation of the
small
bowel
by DBE or intraoperative enteroscopy should be performed in patients with ongoing OGIB and negative or non-specific findings on CE.
[MeSH-major]
Capsule Endoscopy. Diagnostic Errors / prevention & control. Endoscopy, Gastrointestinal / methods. Gastrointestinal Hemorrhage / etiology.
Intestinal
Neoplasms / pathology.
Intestine
,
Small
/ pathology
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.
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[Cites]
Endoscopy. 2003 Dec;35(12):985-91
[
14648408.001
]
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Am Surg. 1995 Aug;61(8):698-702; discussion 702-3
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14988816.001
]
(PMID = 18270840.001).
[ISSN]
0163-2116
[Journal-full-title]
Digestive diseases and sciences
[ISO-abbreviation]
Dig. Dis. Sci.
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article; Multicenter Study
[Publication-country]
United States
49.
Agrawal S, McCarron EC, Gibbs JF, Nava HR, Wilding GE, Rajput A:
Surgical management and outcome in primary adenocarcinoma of the small bowel.
Ann Surg Oncol
; 2007 Aug;14(8):2263-9
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[Title]
Surgical management and outcome in primary
adenocarcinoma of
the
small
bowel
.
BACKGROUND: Primary
adenocarcinoma of
the
small
bowel
is a rare malignancy and is associated with poor survival outcome.
METHODS: Between 1971 and 2005, 64 patients with primary
adenocarcinoma of
the
small
bowel
were treated at our institution.
RESULTS: The most common clinical features at presentation included abdominal pain (n = 33; 51.6%) or
bowel
obstruction (n = 20; 31.3%).
The most frequently involved portion of the
small
bowel
was the duodenum (n = 41; 64%).
A segmental
bowel
resection was performed in 30 patients and pancreaticoduodenectomy in 14 patients.
[MeSH-major]
Adenocarcinoma
/
diagnosis
.
Adenocarcinoma
/ pathology.
Adenocarcinoma
/ surgery.
Intestinal
Neoplasms /
diagnosis
.
Intestinal
Neoplasms / pathology.
Intestinal
Neoplasms / surgery
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(PMID = 17549572.001).
[ISSN]
1068-9265
[Journal-full-title]
Annals of surgical oncology
[ISO-abbreviation]
Ann. Surg. Oncol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
50.
Nicholl MB, Ahuja V, Conway WC, Vu VD, Sim MS, Singh G:
Small bowel adenocarcinoma: understaged and undertreated?
Ann Surg Oncol
; 2010 Oct;17(10):2728-32
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[Title]
Small
bowel
adenocarcinoma
: understaged and undertreated?
BACKGROUND: Primary
small
bowel
adenocarcinoma
(SBA) is a rare, chemoresistant tumor with an aggressive clinical nature.
[MeSH-major]
Intestinal
Neoplasms / pathology.
Intestine
,
Small
/ pathology. Lymph Nodes / pathology
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(PMID = 20458546.001).
[ISSN]
1534-4681
[Journal-full-title]
Annals of surgical oncology
[ISO-abbreviation]
Ann. Surg. Oncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
51.
Vagholkar K, Mathew T:
Adenocarcinoma of the small bowel: a surgical dilemma.
Saudi J Gastroenterol
; 2009 Oct-Dec;15(4):264-7
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[Title]
Adenocarcinoma of
the
small
bowel
: a surgical dilemma.
Malignant tumors of the
small intestine
are among the rarest types of gastrointestinal cancers.
Due to their infrequent occurrence and the multitude of tumor types (viz,
adenocarcinomas
, carcinoids, sarcomas, and lymphomas), not much is known about their natural history and presentation, and there is often delay in
the diagnosis
.
Adenocarcinoma
is the commonest histologic type
of small
bowel
cancer.
In this article, a case
of adenocarcinoma
of the jejunum presenting as an abdominal lump is presented, along with a review of the literature.
[MeSH-major]
Adenocarcinoma
/ pathology.
Adenocarcinoma
/ surgery. Jejunal Neoplasms / pathology. Jejunal Neoplasms / surgery
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.
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[Cites]
Dig Dis. 1996 Jul-Aug;14(4):245-57
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[ISSN]
1998-4049
[Journal-full-title]
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
[ISO-abbreviation]
Saudi J Gastroenterol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Saudi Arabia
[Other-IDs]
NLM/ PMC2981845
52.
van Kouwen MC, Laverman P, van Krieken JH, Oyen WJ, Nagengast FM, Drenth JP:
Noninvasive monitoring of colonic carcinogenesis: feasibility of [(18)F]FDG-PET in the azoxymethane model.
Nucl Med Biol
; 2006 Feb;33(2):245-8
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To address this issue, we studied the FDG uptake in AOM-induced rat colorectal
adenocarcinoma
(CRC) and correlated this with histopathological findings.
RESULTS: Macroscopic examination revealed 21 tumors (7 located in the
small
bowel
and 14 in the colon) in 19 rats.
On histological examination, we found 10 colonic
adenocarcinomas
(the first being observed at Week 22) and 7
adenocarcinoma
in the
small
bowel
.
The [(18)F]FDG accumulation in
small intestine
carcinomas was well beyond background accumulation (P<.0001).
On PET scanning, two rats showed focal accumulation of the abdominal area, corresponding to
small intestine
carcinomas.
CONCLUSION:
Adenocarcinomas
had a significantly higher [(18)F]FDG uptake than background
bowel
uptake.
[MeSH-major]
Adenocarcinoma
/ metabolism.
Adenocarcinoma
/ radionuclide imaging. Colonic Neoplasms / metabolism. Colonic Neoplasms / radionuclide imaging. Disease Models, Animal. Fluorodeoxyglucose F18 / pharmacokinetics
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(PMID = 16546679.001).
[ISSN]
0969-8051
[Journal-full-title]
Nuclear medicine and biology
[ISO-abbreviation]
Nucl. Med. Biol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; MO0N1J0SEN / Azoxymethane
53.
Erra S, Costamagna D, Botto G, Gemme C, Durando R:
Sporadic flat ileal adenocarcinoma: an intriguing challenge in the comprehension of a rare neoplasia and its genesis. Case report and review of literature.
G Chir
; 2009 Mar;30(3):87-92
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[Title]
Sporadic flat ileal
adenocarcinoma
: an intriguing challenge in the comprehension of a rare neoplasia and its genesis. Case report and review of literature.
Small
bowel
adenocarcinoma
is a rare tumor, with a still not well studied tumorigenesis process, usually presenting in an advanced stage.
The clinical
diagnosis
is often difficult; surgery is the treatment of choice when feasible, while the chemotherapeutic approach is still not well standardized.
The gross appearance resembled an inflammatory
bowel
disease, but microscopic examination revealed the extensive presence of an infiltrating ileal
adenocarcinoma
.
Literature about
small
bowel
adenocarcinoma
has been reviewed for better understanding its pathogenesis.
[MeSH-major]
Adenocarcinoma
/ pathology.
Adenocarcinoma
/ surgery. Ileal Neoplasms / pathology. Ileal Neoplasms / surgery
[MeSH-minor]
Aged. Anastomosis, Surgical.
Diagnosis
, Differential. Digestive System Surgical Procedures / methods. Humans. Male. Treatment Outcome
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(PMID = 19351457.001).
[ISSN]
0391-9005
[Journal-full-title]
Il Giornale di chirurgia
[ISO-abbreviation]
G Chir
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
Italy
[Number-of-references]
44
54.
Breuhahn K, Singh S, Schirmacher P, Bläker H:
Large-scale N-terminal deletions but not point mutations stabilize beta-catenin in small bowel carcinomas, suggesting divergent molecular pathways of small and large intestinal carcinogenesis.
J Pathol
; 2008 Jul;215(3):300-7
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[Title]
Large-scale N-terminal deletions but not point mutations stabilize beta-catenin in
small
bowel
carcinomas, suggesting divergent molecular pathways
of small
and large
intestinal
carcinogenesis.
Small
intestinal
adenocarcinoma
is rare and its molecular pathogenesis is incompletely understood.
In order to elucidate the molecular background of beta-catenin stabilization in
small
intestinal
adenocarcinoma
, we investigated 20 non-familial adenomatous polyposis coli (FAP)-associated tumours, including five microsatellite-unstable carcinomas for beta-catenin alterations, by immunohistochemistry, western blot analysis and sequence analysis on the RNA and DNA levels.
Our data show that large intragenic CTNNB1 mutations stabilize beta-catenin in
small
intestinal adenocarcinomas
and influence the subcellular distribution of the protein.
In contrast to colon carcinomas, neither APC nor CTNNB1 point mutations seem to play a significant role in carcinogenesis, indicating divergent mechanisms of wnt/wingless control in the
small
and the large
intestine
.
[MeSH-major]
Adenocarcinoma
/ genetics.
Intestinal
Neoplasms / genetics. Sequence Deletion. beta Catenin / genetics
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[Copyright]
Copyright (c) 2008 Pathological Society of Great Britain and Ireland.
(PMID = 18491352.001).
[ISSN]
0022-3417
[Journal-full-title]
The Journal of pathology
[ISO-abbreviation]
J. Pathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / CTNNB1 protein, human; 0 / Wnt Proteins; 0 / beta Catenin
55.
Kersting S, Bruewer M, Laukoetter MG, Rijcken EM, Mennigen R, Buerger H, Senninger N, Krieglstein CF:
Intestinal cancer in patients with Crohn's disease.
Int J Colorectal Dis
; 2007 Apr;22(4):411-7
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[Title]
Intestinal
cancer in patients with Crohn's disease.
BACKGROUND: Surveillance of
intestinal
cancer in Crohn's disease (CD) has often been advocated.
To date, no clear evidence exists whether CD patients are at special risk for
intestinal
cancer.
An increased incidence
of small
bowel
adenocarcinoma
is suggested.
We report our experience with 10 cases of CD complicated by
intestinal
adenocarcinoma
.
Data of patients that developed carcinoma within Crohn's lesions of either
small
or large
bowel
were analyzed.
Mean age at the time of
diagnosis
of CD was 43 years.
Mean duration of CD until
diagnosis
of cancer was 14 years.
Delayed
diagnosis
resulted in a poor prognosis.
[MeSH-major]
Crohn Disease / complications.
Intestinal
Neoplasms / etiology
[MeSH-minor]
Adult. Colorectal Neoplasms. Databases, Factual. Female. Humans. Ileitis. Incidence.
Intestinal
Fistula. Male. Middle Aged. Survival Rate
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.
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.
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[ISSN]
0179-1958
[Journal-full-title]
International journal of colorectal disease
[ISO-abbreviation]
Int J Colorectal Dis
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
56.
Czaykowski P, Hui D:
Chemotherapy in small bowel adenocarcinoma: 10-year experience of the British Columbia Cancer Agency.
Clin Oncol (R Coll Radiol)
; 2007 Mar;19(2):143-9
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[Title]
Chemotherapy in
small
bowel
adenocarcinoma
: 10-year experience of the British Columbia Cancer Agency.
AIMS:
Small
bowel
adenocarcinoma
(SBA) is a rare, frequently lethal, malignancy.
[MeSH-major]
Adenocarcinoma
/ drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Intestinal
Neoplasms / drug therapy.
Intestine
,
Small
/ drug effects
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(PMID = 17355111.001).
[ISSN]
0936-6555
[Journal-full-title]
Clinical oncology (Royal College of Radiologists (Great Britain))
[ISO-abbreviation]
Clin Oncol (R Coll Radiol)
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
57.
Khelifi S, Bouhafa A, Agrebi W, Cherif A, Ben M, Khayat O, Letaief A:
[Filiation hamartoma polyposis dysplasia and small bowel adenocarcinoma].
Tunis Med
; 2006 Feb;84(2):128-30
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[Title]
[Filiation hamartoma polyposis dysplasia and
small
bowel
adenocarcinoma
].
Transformation of the polyposis hamartoma into a site of dysplasia then into
adenocarcinoma
has been rarely reported.
[MeSH-major]
Adenocarcinoma
/ complications. Ileal Neoplasms / complications. Peutz-Jeghers Syndrome /
diagnosis
MedlinePlus Health Information.
consumer health - Intestinal Cancer
.
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(PMID = 16755980.001).
[ISSN]
0041-4131
[Journal-full-title]
La Tunisie médicale
[ISO-abbreviation]
Tunis Med
[Language]
fre
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Tunisia
58.
Durno CA, Holter S, Sherman PM, Gallinger S:
The gastrointestinal phenotype of germline biallelic mismatch repair gene mutations.
Am J Gastroenterol
; 2010 Nov;105(11):2449-56
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The aim of this study was to characterize patients with GI
small
bowel
and/or colorectal cancers (CRCs) who have germline biallelic MMR mutations.
RESULTS: The database identified 237 patients with
intestinal
cancer diagnosed before the age of 35 years.
Among the 29 patients with CRCs, the mean age of first cancer
diagnosis
was 16.4 years (range: 5-28).
Six individuals with biallelic MMR gene mutations have been reported with
small
bowel
adenocarcinoma
(mean age 20 years (range: 11-41)).
CONCLUSIONS: Biallelic MMR mutations are an underrecognized cause
of small
bowel
and colonic cancers in children and young adults.
[MeSH-major]
Alleles. Colorectal Neoplasms / genetics. DNA Mismatch Repair. Genetic Predisposition to Disease. Germ-Line Mutation.
Intestinal
Neoplasms / genetics
[MeSH-minor]
Adolescent. Adult. Child. Child, Preschool. DNA Mutational Analysis. Databases, Factual. Humans.
Intestine
,
Small
. Microsatellite Instability. Phenotype. Registries
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(PMID = 20531397.001).
[ISSN]
1572-0241
[Journal-full-title]
The American journal of gastroenterology
[ISO-abbreviation]
Am. J. Gastroenterol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
59.
Sugae T, Yaguchi T, Kajikawa M, Nakayama S, Takase T, Inokawa Y, Tsushima Y, Watanabe T, Harada A:
[A case report of primary adenocarcinoma of small intestine successfully treated with FOLFOX].
Gan To Kagaku Ryoho
; 2008 Nov;35(11):1969-71
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[Title]
[A case report of primary
adenocarcinoma of small intestine
successfully treated with FOLFOX].
This is an account of a case of primary
adenocarcinoma of
the
small intestine
successfully treated with chemotherapy.
Abdominal computerized tomography revealed
bowel
obstruction, and this was found at surgery to be due to a tumor at the jejunum 100 cm distal from the Treitz ligament.
Pathological
diagnosis
of the resected specimen was
adenocarcinoma
.
Primary
small
intestinal
adenocarcinoma
is a rare disease with a dismal prognosis.
The current patient survived for 4 years and 5 months after
the diagnosis
, owing at least partially to the mFOLFOX6 which was found to be the only active regimen.
[MeSH-major]
Adenocarcinoma
/ drug therapy.
Adenocarcinoma
/ pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Intestinal
Neoplasms / drug therapy.
Intestinal
Neoplasms / pathology.
Intestine
,
Small
/ drug effects
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.
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LEUCOVORIN
.
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(PMID = 19011354.001).
[ISSN]
0385-0684
[Journal-full-title]
Gan to kagaku ryoho. Cancer & chemotherapy
[ISO-abbreviation]
Gan To Kagaku Ryoho
[Language]
jpn
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Carcinoembryonic Antigen; 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
60.
Moran JA, Lemberger K, Cadoré JL, Lepage OM:
Small intestine adenocarcinoma in conjunction with multiple adenomas causing acute colic in a horse.
J Vet Diagn Invest
; 2008 Jan;20(1):121-4
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[Title]
Small intestine adenocarcinoma
in conjunction with multiple adenomas causing acute colic in a horse.
An 11-year-old Andalusian stallion developed marked signs of colic associated with an acute
small intestine
obstruction.
Exploratory laparotomy revealed a distal jejunum full-thickness wall induration and multiple
small
adherent intraluminal masses.
Histologic examination revealed an
adenocarcinoma
and multiple polypoid adenomas.
Colic was considered secondary to partial jejunal lumen obstruction by the
adenocarcinoma
.
Adenocarcinoma
recurrence or transformation from remaining adenomas into an
adenocarcinoma
is still a major risk.
[MeSH-major]
Adenocarcinoma
/ veterinary. Colic / veterinary. Horse Diseases / pathology.
Intestinal
Neoplasms / veterinary.
Intestine
,
Small
/ pathology
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(PMID = 18182527.001).
[ISSN]
1040-6387
[Journal-full-title]
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
[ISO-abbreviation]
J. Vet. Diagn. Invest.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
61.
Mehta MV, Porecha MM, Mehta PJ:
Small intestinal adenocarcinoma in Peutz-Jeghers syndrome.
Indian J Gastroenterol
; 2006 Jan-Feb;25(1):38-9
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[Title]
Small
intestinal
adenocarcinoma
in Peutz-Jeghers syndrome.
Peutz-Jeghers syndrome (PJS) is characterized by
intestinal
hamartomatous polyposis (usually affecting the jejunum) and mucocutaneous melanin spots.
We report a 25-year-old man with PJS who developed
small
intestinal
adenocarcinoma
and presented with
small
bowel
obstruction due to jejuno-ileal intussusception.
[MeSH-major]
Adenocarcinoma
/ etiology. Jejunal Neoplasms / etiology. Peutz-Jeghers Syndrome / complications
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.
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(PMID = 16567896.001).
[ISSN]
0254-8860
[Journal-full-title]
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
[ISO-abbreviation]
Indian J Gastroenterol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
India
62.
Lee CH, Kim PS, Lee JI, Jeong S, Lee JW, Kwon KS, Lee DH, Kim HG, Shin YW, Kim YS, Kim JM, Jeon YS:
[A case of primary jejunal adenocarcinoma diagnosed by enteroscopy using pediatric colonoscope].
Korean J Gastroenterol
; 2006 Nov;48(5):365-8
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[Title]
[A case of primary jejunal
adenocarcinoma
diagnosed by enteroscopy using pediatric colonoscope].
Endoscopic jejunal biopsy showed moderately differentiated
adenocarcinoma
.
Small
intestinal
adenocarcinoma
is uncommonly encountered in clinical practice.
Because
small intestine
is relatively inaccessible via routine endoscopy,
diagnosis
of small
intestinal
neoplasm is often delayed for several months after the onset of symptoms.
Therefore, when a
small
bowel
neoplasm is suspected, enteroscopy is the most useful study.
If enteroscope is not available, enteroscopy using pediatric colonoscope may permit earlier preoperative
diagnosis
.
We report a case of primary jejunal
adenocarcinoma
diagnosed by endoscopic biopsy using pediatric colonoscope.
[MeSH-major]
Adenocarcinoma
/ pathology. Jejunal Neoplasms / pathology
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.
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(PMID = 17132927.001).
[ISSN]
1598-9992
[Journal-full-title]
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
[ISO-abbreviation]
Korean J Gastroenterol
[Language]
kor
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Korea (South)
63.
Mastoraki A, Konstantiadou I, Papanikolaou I, Christodolou S, Sakorafas G, Peros G:
Adenocarcinoma of the small intestine complicating Crohn's disease.
Int J Colorectal Dis
; 2009 Oct;24(10):1245-6
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[Title]
Adenocarcinoma of
the
small intestine
complicating Crohn's disease.
[MeSH-major]
Adenocarcinoma
/ complications. Crohn Disease / complications.
Intestinal
Neoplasms / complications
[MeSH-minor]
Adult. Aged. Humans. Incidence.
Intestinal
Obstruction / complications. Male. Middle Aged. Spondylitis, Ankylosing / complications
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.
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(PMID = 19408004.001).
[ISSN]
1432-1262
[Journal-full-title]
International journal of colorectal disease
[ISO-abbreviation]
Int J Colorectal Dis
[Language]
eng
[Publication-type]
Case Reports; Letter
[Publication-country]
Germany
64.
Napolitano L, de Nicola P, Di Bartolomeo N, Aceto L, Liddo G, Angelucci D, Innocenti P:
[A case of perforated small bowel adenocarcinoma as first symptom of Crohn's disease].
G Chir
; 2005 May;26(5):212-4
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[Title]
[A case of perforated
small
bowel
adenocarcinoma
as first symptom of Crohn's disease].
[Transliterated title]
Adenocarcinoma
perforato
del
piccolo
intestino
come prima evidente manifestazione
del
morbo di Crohn: case report.
A case of perforated
small
bowel
adenocarcinoma
presenting as first symptom of Crohn's disease is reported in a 53 years old male patient with abdominal pain and alteration of
bowel
habits.
[MeSH-major]
Adenocarcinoma
/ complications. Crohn Disease /
diagnosis
. Ileal Neoplasms / complications.
Intestinal
Perforation / etiology
Genetic Alliance.
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.
MedlinePlus Health Information.
consumer health - Crohn's Disease
.
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.
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(PMID = 16184705.001).
[ISSN]
0391-9005
[Journal-full-title]
Il Giornale di chirurgia
[ISO-abbreviation]
G Chir
[Language]
ita
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Italy
65.
Overman MJ, Kopetz S, Wen S, Hoff PM, Fogelman D, Morris J, Abbruzzese JL, Ajani JA, Wolff RA:
Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma.
Cancer
; 2008 Oct 15;113(8):2038-45
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[Title]
Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic
small
bowel
adenocarcinoma
.
BACKGROUND: Metastatic
small
bowel
adenocarcinoma
(SBA) has a poor prognosis.
The primary tumor site was the jejunum in 35 patients (43%), duodenum in 30 patients (38%), ileum in 6 patients (8%), and nonspecified
small
bowel
in 9 patients (11%).
[MeSH-major]
Adenocarcinoma
/ drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Intestinal
Neoplasms / drug therapy.
Intestine
,
Small
/ pathology
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.
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.
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[Copyright]
(c) 2008 American Cancer Society.
(PMID = 18759326.001).
[ISSN]
0008-543X
[Journal-full-title]
Cancer
[ISO-abbreviation]
Cancer
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / P30 CA016672
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Platinum Compounds; U3P01618RT / Fluorouracil
66.
Postgate A, Despott E, Burling D, Gupta A, Phillips R, O'Beirne J, Patch D, Fraser C:
Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy.
Gastrointest Endosc
; 2008 Dec;68(6):1209-14
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[Title]
Significant
small
-
bowel
lesions detected by alternative diagnostic modalities after negative capsule endoscopy.
BACKGROUND: Capsule endoscopy (CE) is considered a first-line investigation for obscure GI bleeding (OGIB) and
small
-
bowel
polyp or tumor detection.
The reliability of a negative CE in excluding gross
small
-
bowel
pathology remains unclear.
OBJECTIVE: We describe our experience of significant
small
-
bowel
pathology missed at CE in 5 patients.
PATIENTS: Five patients were evaluated: 4 with a history of OGIB (transfusion dependent in 2) and 1 patient with Peutz-Jeghers syndrome (PJS) under
small
-
bowel
surveillance.
MAIN OUTCOME MEASUREMENTS: Detection of significant
small
-
bowel
pathology by using DBE, CT, or MRE after a negative capsule study.
RESULTS: Significant
small
-
bowel
pathology was missed at CE but was detected by alternative modalities in 5 patients.
In 4 patients, the lesions were in the proximal
small
bowel
(
adenocarcinoma
, malignant melanoma, varices, and stromal tumor).
LIMITATIONS: Retrospective case series with
small
numbers.
CONCLUSIONS: Gross pathology may be missed at CE, especially in the proximal
small
bowel
, and a negative CE study does not exclude significant disease.
[MeSH-major]
Capsule Endoscopy. Endoscopy, Gastrointestinal.
Intestinal
Diseases /
diagnosis
.
Intestine
,
Small
/ pathology. Magnetic Resonance Imaging. Tomography, X-Ray Computed
MedlinePlus Health Information.
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.
MedlinePlus Health Information.
consumer health - MRI Scans
.
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[CommentIn]
Gastrointest Endosc. 2008 Dec;68(6):1128-30
[
19028221.001
]
[CommentIn]
Gastrointest Endosc. 2009 Oct;70(4):819; author reply 819-20
[
19788994.001
]
(PMID = 19028234.001).
[ISSN]
1097-6779
[Journal-full-title]
Gastrointestinal endoscopy
[ISO-abbreviation]
Gastrointest. Endosc.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
67.
De Dosso S, Molinari F, Martin V, Frattini M, Saletti P:
Molecular characterisation and cetuximab-based treatment in a patient with refractory small bowel adenocarcinoma.
Gut
; 2010 Nov;59(11):1587-8
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[Title]
Molecular characterisation and cetuximab-based treatment in a patient with refractory
small
bowel
adenocarcinoma
.
[MeSH-major]
Adenocarcinoma
/ drug therapy. Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Ileal Neoplasms / drug therapy
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.
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.
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CETUXIMAB
.
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[CommentOn]
Gut. 2008 Nov;57(11):1631-2
[
18941013.001
]
(PMID = 20732917.001).
[ISSN]
1468-3288
[Journal-full-title]
Gut
[ISO-abbreviation]
Gut
[Language]
eng
[Publication-type]
Case Reports; Comment; Letter
[Publication-country]
England
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; PQX0D8J21J / Cetuximab
68.
Kodaira C, Osawa S, Mochizuki C, Sato Y, Nishino M, Yamada T, Takayanagi Y, Takagaki K, Sugimoto K, Kanaoka S, Furuta T, Ikuma M:
A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy.
World J Gastroenterol
; 2009 Apr 14;15(14):1774-8
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[Title]
A case
of small
bowel
adenocarcinoma
in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy.
Small
bowel
adenocarcinoma
(SBA) in patients with Crohn's disease (CD) is quite rare, difficult to diagnose without surgery, and has a poor prognosis.
PET/CT detected an accumulation spot in the
small
bowel
.
An endoscopic forceps biopsy specimen showed poorly differentiated
adenocarcinoma
.
There were some longitudinal ulcer scars near the tumor, and the chronic inflammation in the
small
bowel
appeared to be associated with the cancer development.
Since early
diagnosis
is extremely difficult in these cases, novel techniques, such as PET/CT and DBE, may be expected to help in making a preoperative
diagnosis
of the development of SBA in CD.
[MeSH-major]
Adenocarcinoma
/
diagnosis
.
Adenocarcinoma
/ etiology. Crohn Disease / complications. Endoscopy, Gastrointestinal / methods.
Intestinal
Neoplasms /
diagnosis
.
Intestinal
Neoplasms / etiology.
Intestine
,
Small
/ pathology
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.
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.
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[Cites]
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]
(PMID = 19360924.001).
[ISSN]
2219-2840
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
China
[Other-IDs]
NLM/ PMC2668786
69.
Miller AD, Kramer JA, Lin KC, Knight H, Martinot A, Mansfield KG:
Small intestinal adenocarcinoma in common marmosets (Callithrix jacchus).
Vet Pathol
; 2010 Sep;47(5):969-76
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[Title]
Small
intestinal
adenocarcinoma
in common marmosets (Callithrix jacchus).
Small
intestinal adenocarcinomas
are uncommon neoplasms that are rarely reported in nonhuman primates.
Herein the authors report the clinical, histologic, immunohistochemical, and molecular characteristics
of small
intestinal
adenocarcinoma
in 10 common marmosets (Callithrix jacchus).
Retrospective analysis of necropsy records revealed
small
intestinal
carcinoma to be the most common neoplastic cause of morbidity and mortality in aged common marmosets.
Nine of 10 (90%) tumors arose within the proximal
small intestine
near the interface with the duodenum.
No Helicobacter-like bacteria were observed via silver stain, and callitrichine herpesvirus 3 was detected by polymerase chain reaction with equal frequency from neoplastic and nonneoplastic
intestinal
sections.
The tumors described in this population illustrate comparable features to human cases
of small intestine
carcinoma and may serve as a potential animal model for
small
intestinal
carcinomas.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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[ISSN]
1544-2217
[Journal-full-title]
Veterinary pathology
[ISO-abbreviation]
Vet. Pathol.
[Language]
ENG
[Grant]
United States / NCRR NIH HHS / RR / T32 RR007000-35; United States / NCRR NIH HHS / RR / P51 RR000168-50; United States / NCRR NIH HHS / RR / T32 RR007000; United States / NCRR NIH HHS / RR / RR00168; United States / NCRR NIH HHS / RR / P51 RR000168; United States / NCRR NIH HHS / RR / K26 RR000168; United States / NCRR NIH HHS / RR / RR07000
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA, Neoplasm
[Other-IDs]
NLM/ NIHMS235944; NLM/ PMC2955325
70.
Namikawa T, Hanazaki K:
Clinical analysis of primary anaplastic carcinoma of the small intestine.
World J Gastroenterol
; 2009 Feb 7;15(5):526-30
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[Title]
Clinical analysis of primary anaplastic carcinoma of the
small intestine
.
Primary anaplastic carcinoma is a rare variant
of small
intestinal
cancer.
Most reports of primary anaplastic carcinoma of the
small intestine
are isolated case reports, therefore the clinicopathological features, therapeutic management, and surgical outcome of this tumor type remain unclear.
This review analyzes the available clinical characteristics of primary anaplastic carcinoma of the
small intestine
and investigates key differences from differentiated
adenocarcinoma of
the
small intestine
.
A Medline search was performed using the keywords '
small intestine
' and 'anaplastic carcinoma' or 'undifferentiated carcinoma'.
The literature revealed a poor prognosis for patients who underwent surgical resection for anaplastic carcinoma of the
small intestine
, which gave a 3-year overall survival rate of 10.8% and a median survival time of 5.0 mo.
The literature suggests that anaplastic carcinoma is markedly more aggressive than differentiated
adenocarcinoma of
the
small intestine
.
Surgical resection with the aim of complete tumor removal provides the only beneficial therapeutic option for patients with anaplastic carcinoma of the
small intestine
, because chemotherapy and radiation therapy have no significant effect on the rate of survival.
However, despite complete tumor resection, most patients with anaplastic carcinoma of the
small intestine
are at great risk of disease recurrence.
This report also highlights the importance of a systematic diagnostic approach for anaplastic carcinoma of the
small intestine
.
[MeSH-major]
Carcinoma / pathology.
Intestinal
Neoplasms / pathology
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Female. Humans.
Intestinal
Mucosa / pathology.
Intestine
,
Small
/ pathology. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis. Survivors
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[ISSN]
2219-2840
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Editorial
[Publication-country]
China
[Other-IDs]
NLM/ PMC2653339
71.
Zaanan A, Afchain P, Carrere N, Aparicio T:
[Small bowel adenocarcinoma].
Gastroenterol Clin Biol
; 2010 Aug-Sep;34(6-7):371-9
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[Title]
[
Small
bowel
adenocarcinoma
].
[Transliterated title]
Adénocarcinome
de l
'
intestin
grêle.
Small
bowel
adenocarcinoma
is a rare tumor.
Diagnosis
is usually performed at an advanced stage because of non-specific nature of clinical manifestations.
New methods of radiological and endoscopic exploration
of small intestine
should allow earlier
diagnosis
.
A national prospective cohort study is currently evaluating the results of chemotherapy (recommended protocol: FOLFOX) as adjuvant and palliative treatment
of small
bowel
adenocarcinoma
.
[MeSH-major]
Adenocarcinoma
/ etiology.
Adenocarcinoma
/ therapy.
Intestinal
Neoplasms / etiology.
Intestinal
Neoplasms / therapy
[MeSH-minor]
Chemotherapy, Adjuvant. Genetic Predisposition to Disease. Humans.
Intestine
,
Small
/ pathology.
Intestine
,
Small
/ surgery. Lymphatic Metastasis. Neoplasm Metastasis. Prognosis. Risk Factors
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[Copyright]
Copyright 2010 Elsevier Masson SAS. All rights reserved.
(PMID = 20537487.001).
[ISSN]
0399-8320
[Journal-full-title]
Gastroentérologie clinique et biologique
[ISO-abbreviation]
Gastroenterol. Clin. Biol.
[Language]
fre
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
France
72.
Eigenbrod T, Kullmann F, Klebl F:
Resection of small bowel adenocarcinoma liver metastasis combined with neoadjuvant and adjuvant chemotherapy results in extended disease-free period--a case report.
Int J Gastrointest Cancer
; 2006;37(2-3):94-7
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[Title]
Resection
of small
bowel
adenocarcinoma
liver metastasis combined with neoadjuvant and adjuvant chemotherapy results in extended disease-free period--a case report.
Small
bowel
adenocarcinoma
(SBA) is a very rare tumor entity but occurs in up to 5% of patients suffering from familiar adenomatous polyposis (FAP).
Because of nonspecific symptoms,
diagnosis
is usually made with delay, which contributes to high rates of metastatic disease at the time of
diagnosis
.
In October 2001, a 51-year-old woman with attenuated FAP, that had total proctocolectomy in 1994 was diagnosed with a jejunal
adenocarcinoma
.
She subsequently underwent
small
bowel
resection.
Afterwards, a
small
residual lesion in segment VIII was seen in CT scan but could not be identified by PET and at laparotomy in November 2002.
[MeSH-major]
Adenocarcinoma
/ therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hepatectomy. Ileal Neoplasms / therapy. Jejunal Neoplasms / therapy. Liver Neoplasms / therapy. Neoadjuvant Therapy
Genetic Alliance.
consumer health - Liver Disease
.
MedlinePlus Health Information.
consumer health - Intestinal Cancer
.
MedlinePlus Health Information.
consumer health - Liver Cancer
.
Hazardous Substances Data Bank.
FLUOROURACIL
.
Hazardous Substances Data Bank.
LEUCOVORIN
.
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11450920.001
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(PMID = 17827529.001).
[ISSN]
1537-3649
[Journal-full-title]
International journal of gastrointestinal cancer
[ISO-abbreviation]
Int J Gastrointest Cancer
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0H43101T0J / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
73.
Toyomasu Y, Tsutsumi S, Yamaguchi S, Mochiki E, Asao T, Kuwano H:
Primary mucinous adenocarcinoma of the ileum.
Int Surg
; 2010 Jan-Mar;95(1):60-2
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[Title]
Primary mucinous
adenocarcinoma of
the ileum.
A laparotomy was performed on a 67-year-old woman with a provisional
diagnosis
of
intestinal
obstruction from a primary
small
bowel
carcinoma.
A pathological examination showed a mucinous
adenocarcinoma of
the ileum, with no regional lymph node metastases.
Primary
small
bowel
adenocarcinoma
is rare in all malignant gastrointestinal neoplasms, and very few cases of the ileal mucinous
adenocarcinoma
have been reported.
We performed a radical operation for the ileal mucinous
adenocarcinoma
, and long-term survival was obtained.
This case suggests that aggressive surgical treatment for an advanced stage
of small
bowel
cancer leads to long-term survival.
[MeSH-major]
Adenocarcinoma
, Mucinous / surgery. Ileal Neoplasms / surgery
[MeSH-minor]
Aged. Cecal Neoplasms / pathology. Digestive System Surgical Procedures. Fatal Outcome. Female. Humans.
Intestinal
Obstruction / etiology. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Peritoneal Neoplasms / pathology. Time Factors
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(PMID = 20480843.001).
[ISSN]
0020-8868
[Journal-full-title]
International surgery
[ISO-abbreviation]
Int Surg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Italy
74.
McGowan CE, Lagares-Garcia JA, Bhattacharya B:
Retained capsule endoscope leading to the identification of small bowel adenocarcinoma in a patient with undiagnosed Crohn disease.
Ann Diagn Pathol
; 2009 Dec;13(6):390-3
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[Title]
Retained capsule endoscope leading to the identification
of small
bowel
adenocarcinoma
in a patient with undiagnosed Crohn disease.
Small
intestinal
neoplasia is a rare condition that frequently presents a diagnostic challenge.
We describe the case of a 70-year-old patient who presented with several years of chronic, intermittent abdominal pain, previously diagnosed as irritable
bowel
syndrome.
Radiographic evaluation, including upper gastrointestinal series with
small
bowel
follow-through and computed tomography, demonstrated dilated
small
bowel
with possible strictures.
Extensive flat and polypoid high- and low-grade dysplasia were present, as well as an area of well-differentiated
adenocarcinoma
invading into the muscularis propria.
We discuss the epidemiology, pathogenesis, and
diagnosis
of small
bowel
malignancy.
[MeSH-major]
Adenocarcinoma
/
diagnosis
. Capsule Endoscopy. Crohn Disease /
diagnosis
. Ileal Neoplasms /
diagnosis
[MeSH-minor]
Abdominal Pain /
diagnosis
. Abdominal Pain / etiology. Aged. Humans. Male. Neoplasm Staging. Staining and Labeling. Treatment Outcome
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.
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(PMID = 19917475.001).
[ISSN]
1532-8198
[Journal-full-title]
Annals of diagnostic pathology
[ISO-abbreviation]
Ann Diagn Pathol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
75.
Kronberger IE, Graziadei IW, Vogel W:
Small bowel adenocarcinoma in Crohn's disease: a case report and review of literature.
World J Gastroenterol
; 2006 Feb 28;12(8):1317-20
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[Title]
Small
bowel
adenocarcinoma
in Crohn's disease: a case report and review of literature.
Small
bowel adenocarcinomas
are remarkable for their rarity, difficult
diagnosis
and poor prognosis.
Here we report an unusual case of a 33-year-old patient in whom infiltrative
adenocarcinoma of
the
small
bowel
was diagnosed after a 10-year history of Crohn's disease.
In most previously reported cases, detection of Crohn's disease was subsequent to that of carcinoma of the
small
bowel
or the patients involved had an even longer history of the disease.
Our literature review suggests that the risk
of small
bowel
adenocarcinoma
is higher in patients with Crohn's disease than in the overall population.
[MeSH-major]
Adenocarcinoma
/ complications.
Adenocarcinoma
/
diagnosis
. Crohn Disease / complications. Crohn Disease /
diagnosis
. Ileal Neoplasms / complications. Ileal Neoplasms /
diagnosis
Genetic Alliance.
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.
MedlinePlus Health Information.
consumer health - Crohn's Disease
.
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.
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.
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.
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[ISSN]
1007-9327
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
China
[Chemical-registry-number]
0 / Anti-Inflammatory Agents, Non-Steroidal; 4Q81I59GXC / Mesalamine; MRK240IY2L / Azathioprine
[Number-of-references]
60
[Other-IDs]
NLM/ PMC4124452
76.
Cardona DM, Zhang X, Liu C:
Loss of carbamoyl phosphate synthetase I in small-intestinal adenocarcinoma.
Am J Clin Pathol
; 2009 Dec;132(6):877-82
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[Title]
Loss of carbamoyl phosphate synthetase I in
small
-
intestinal
adenocarcinoma
.
Carbamoyl phosphate synthetase I (CPS1), normally found in hepatocytes and
small
-
intestine
(SI) enterocytes, is the antigen of Hep Par 1 antibody.
Expression of CPS1 in invasive SI
adenocarcinoma
seems to be lost.
We retrospectively collected 36 total specimens, which included 31 SI adenomas and 21
adenocarcinomas
.
Of the 21 invasive
adenocarcinomas
, 15 lost antigen expression (71%).
[MeSH-major]
Adenocarcinoma
/ enzymology. Carbamoyl-Phosphate Synthase (Ammonia) / metabolism. Duodenal Neoplasms / enzymology. Duodenum / enzymology
[MeSH-minor]
Adenoma / enzymology. Adenoma / pathology. Biomarkers, Tumor / metabolism. Duodenitis / enzymology. Duodenitis / pathology. Humans. Immunohistochemistry.
Intestinal
Mucosa / enzymology.
Intestinal
Mucosa / pathology. Neoplasm Invasiveness. Retrospective Studies
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.
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(PMID = 19926579.001).
[ISSN]
1943-7722
[Journal-full-title]
American journal of clinical pathology
[ISO-abbreviation]
Am. J. Clin. Pathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; EC 6.3.4.16 / Carbamoyl-Phosphate Synthase (Ammonia)
77.
Sumrall A, Soni N:
Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association?
Int J Gastrointest Cancer
; 2006;37(4):146-8
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[Title]
Dermatofibrosarcoma protuberans and
small
bowel
adenocarcinoma
: coincidental occurrence or genetic association?
After surgical excision and radiotherapy of dermatofibrosarcoma protuberans, the patient developed
small
bowel
adenocarcinoma
.
[MeSH-major]
Adenocarcinoma
/ pathology. Dermatofibrosarcoma / pathology.
Intestinal
Neoplasms / pathology. Neoplasms, Second Primary / pathology. Skin Neoplasms / pathology
[MeSH-minor]
Adult. Humans.
Intestine
,
Small
/ diagnostic imaging.
Intestine
,
Small
/ pathology. Male. Radiography. Tumor Suppressor Protein p53 / genetics
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[Cites]
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[ISSN]
1537-3649
[Journal-full-title]
International journal of gastrointestinal cancer
[ISO-abbreviation]
Int J Gastrointest Cancer
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
78.
Beaugerie L, Sokol H, Seksik P:
Noncolorectal malignancies in inflammatory bowel disease: more than meets the eye.
Dig Dis
; 2009;27(3):375-81
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[Title]
Noncolorectal malignancies in inflammatory
bowel
disease: more than meets the eye.
In patients with Crohn's disease, the risk
of small
bowel
adenocarcinoma
is 20-40 times higher than the low background risk of the general population.
In the subset of patients with longstanding
small
bowel
lesions, the absolute risk
of small
bowel
adenocarcinoma
exceeds 1 per 100 patient-years after 25 years of follow-up and becomes equivalent to the risk of colorectal cancer.
Growing evidence suggests that the pathogenesis
of small
bowel
adenocarcinoma
arising in inflammatory lesions of Crohn's disease is similar to that of colorectal cancer complicating chronic colonic inflammation (inflammation-dysplasia-cancer sequence).
However, contrasting with the established endoscopic detection of colonic advanced neoplasias in patients with longstanding extensive colitis, there is no consensus at this time how to face the excess-risk
of small
bowel
adenocarcinoma
in patients at high risk.
There are no specific clinical or imaging alert signs and endoscopic surveillance of the totality of the inflamed
small
bowel
mucosa would suppose to perform repeated enteroscopies, with the potential limiting factor of stenosis.
Data from referral centers and from the CESAME cohort suggest that
intestinal
lymphomas may arise in the chronically inflamed segments in patients with inflammatory
bowel
disease (IBD).
[MeSH-major]
Colorectal Neoplasms / complications. Inflammatory
Bowel
Diseases / complications
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[Copyright]
Copyright 2009 S. Karger AG, Basel.
(PMID = 19786768.001).
[ISSN]
1421-9875
[Journal-full-title]
Digestive diseases (Basel, Switzerland)
[ISO-abbreviation]
Dig Dis
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Switzerland
[Number-of-references]
46
79.
Delaunoit T, Neczyporenko F, Limburg PJ, Erlichman C:
Pathogenesis and risk factors of small bowel adenocarcinoma: a colorectal cancer sibling?
Am J Gastroenterol
; 2005 Mar;100(3):703-10
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[Title]
Pathogenesis and risk factors
of small
bowel
adenocarcinoma
: a colorectal cancer sibling?
Small
bowel
adenocarcinoma
(SBA) is a very rare entity accounting for one-fourth of the
small intestine
neoplasms.
It appears that SBA shares several genetic characteristics with large
bowel
tumors, but also has unique features.
[MeSH-major]
Adenocarcinoma
/ etiology.
Intestinal
Neoplasms / etiology.
Intestine
,
Small
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(PMID = 15743371.001).
[ISSN]
0002-9270
[Journal-full-title]
The American journal of gastroenterology
[ISO-abbreviation]
Am. J. Gastroenterol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
United States
[Number-of-references]
101
80.
Boldery J, Gleeson J, Jordaan J:
Superior mesenteric artery syndrome following small bowel resection.
ANZ J Surg
; 2006 Sep;76(9):861-2
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[Title]
Superior mesenteric artery syndrome following
small
bowel
resection.
Superior mesenteric artery syndrome is a rare cause of mechanical
intestinal
obstruction.
We present a case of superior mesenteric artery syndrome following resection of a primary
adenocarcinoma of
the
small
bowel
.
[MeSH-major]
Adenocarcinoma
/ surgery. Jejunal Neoplasms / surgery. Postoperative Complications / etiology. Superior Mesenteric Artery Syndrome / etiology
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.
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(PMID = 16922913.001).
[ISSN]
1445-1433
[Journal-full-title]
ANZ journal of surgery
[ISO-abbreviation]
ANZ J Surg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Australia
81.
Zhang MQ, Lin F, Hui P, Chen ZM, Ritter JH, Wang HL:
Expression of mucins, SIMA, villin, and CDX2 in small-intestinal adenocarcinoma.
Am J Clin Pathol
; 2007 Nov;128(5):808-16
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[Title]
Expression of mucins, SIMA, villin, and CDX2 in
small
-
intestinal
adenocarcinoma
.
Expression of gastrointestinal biomarkers MUC1, MUC2, MUC5AC,
small
-
intestinal
mucin antigen (SIMA), villin, and CDX2 has been studied in colorectal
adenocarcinoma
(CRC).
Little is known, however, about their expression in
small
-
intestinal
adenocarcinoma
(SIA).
[MeSH-major]
Adenocarcinoma
/ metabolism. Biomarkers, Tumor / metabolism.
Intestinal
Neoplasms / metabolism.
Intestine
,
Small
/ metabolism. Neoplasm Proteins / metabolism
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(PMID = 17951204.001).
[ISSN]
0002-9173
[Journal-full-title]
American journal of clinical pathology
[ISO-abbreviation]
Am. J. Clin. Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Microfilament Proteins; 0 / Mucins; 0 / Neoplasm Proteins; 0 / gastro-intestinal mucus-associated antigens; 0 / villin
82.
Bai M, Katsanos KH, Economou M, Kamina S, Balli C, Briasoulis E, Kappas AM, Agnantis N, Tsianos EV:
Rectal Epstein-Barr virus-positive Hodgkin's lymphoma in a patient with Crohn's disease: case report and review of the literature.
Scand J Gastroenterol
; 2006 Jul;41(7):866-9
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We present the case of a 35-year-old man with Crohn's disease diagnosed at the age of 27, several months after an operation for
small
-
bowel
adenocarcinoma
.
Seven years after the
adenocarcinoma
diagnosis
, the patient presented with severe continuous anal pain and diarrhea.
Sigmoidoscopy and subsequent biopsies from an ulcerated rectal area supported
the diagnosis
of Epstein-Barr virus-positive (EBV+) primary Hodgkin's lymphoma.
[MeSH-minor]
Adult. Humans. Immunosuppressive Agents. Male. Neoplasms, Second Primary /
diagnosis
. Neoplasms, Second Primary / virology
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(PMID = 16785203.001).
[ISSN]
0036-5521
[Journal-full-title]
Scandinavian journal of gastroenterology
[ISO-abbreviation]
Scand. J. Gastroenterol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
Norway
[Chemical-registry-number]
0 / Immunosuppressive Agents
[Number-of-references]
28
83.
von Rahden BH, Brücher BL, Langner C, Siewert JR, Stein HJ, Sarbia M:
Expression of cyclo-oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor beta1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of the small intestine.
Br J Surg
; 2006 Nov;93(11):1424-32
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[Title]
Expression of cyclo-oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor beta1, and their relationship with vascular endothelial growth factors A and C, in primary
adenocarcinoma of
the
small intestine
.
BACKGROUND: Primary
adenocarcinomas
of the
small intestine
are rare.
METHODS: Expression of cyclo-oxygenase (COX) 1 and 2, prostaglandin E synthase (PGES), TGF-beta1 and vascular endothelial growth factor (VEGF) A and C genes was analysed in 54 primary
adenocarcinomas
of the
small intestine
and corresponding normal
intestinal
mucosa.
COX-1, COX-2, VEGF-A, VEGF-C, PGES and TGF-beta1 mRNA expression varied markedly in different tumours, but all were overexpressed compared with levels in normal
intestinal
mucosa.
CONCLUSION: Correlations between levels of mRNA for COX-1, COX-2, TGF-beta1 and PGES and those for proangiogenic factors VEGF-A and VEGF-C suggest a role for these factors in the propagation of primary
adenocarcinomas
of the
small intestine
.
[MeSH-major]
Adenocarcinoma
/ metabolism. Ileal Neoplasms / metabolism. Neoplasm Proteins / metabolism. Prostaglandin-Endoperoxide Synthases / metabolism. Transforming Growth Factor beta1 / metabolism. Vascular Endothelial Growth Factors / metabolism
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(PMID = 17022010.001).
[ISSN]
0007-1323
[Journal-full-title]
The British journal of surgery
[ISO-abbreviation]
Br J Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / Transforming Growth Factor beta1; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / Vascular Endothelial Growth Factor C; 0 / Vascular Endothelial Growth Factors; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
84.
Al-Amri A, Al-Quorain AA:
Coexisting malignant lymphoma of the duodenum and adenocarcinoma of the colon.
Saudi Med J
; 2007 Mar;28(3):463-4
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[Title]
Coexisting malignant lymphoma of the duodenum and
adenocarcinoma of
the colon.
Synchronous malignant mucosa associated lymphoid tissue MALT-lymphoma of the
small
bowel
and
adenocarcinoma of
the colon in the same patient is a scarce rarity.
Thus, it might be of interest to report such a case of coexisting malignant MALT-lymphoma of the duodenum and
adenocarcinoma of
the large
bowel
.
[MeSH-major]
Adenocarcinoma
/ pathology. Colonic Neoplasms / pathology. Duodenal Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Neoplasms, Multiple Primary / pathology
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(PMID = 17334482.001).
[ISSN]
0379-5284
[Journal-full-title]
Saudi medical journal
[ISO-abbreviation]
Saudi Med J
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Saudi Arabia
85.
Ono M, Shirao K, Takashima A, Morizane C, Okita N, Takahari D, Hirashima Y, Eguchi-Nakajima T, Kato K, Hamaguchi T, Yamada Y, Shimada Y:
Combination chemotherapy with cisplatin and irinotecan in patients with adenocarcinoma of the small intestine.
Gastric Cancer
; 2008;11(4):201-5
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[Title]
Combination chemotherapy with cisplatin and irinotecan in patients with
adenocarcinoma of
the
small intestine
.
BACKGROUND:
Small
-
bowel
adenocarcinoma
(SBA) is a rare tumor that has a poor response to chemotherapy and a poor prognosis.
[MeSH-major]
Adenocarcinoma
/ drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Cisplatin / administration & dosage.
Intestinal
Neoplasms / drug therapy
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CIS-DIAMINEDICHLOROPLATINUM
.
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[Cites]
Br J Cancer. 1998 Aug;78(4):508-10
[
9716035.001
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J Clin Oncol. 1999 Jan;17 (1):319-23
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(PMID = 19132481.001).
[ISSN]
1436-3291
[Journal-full-title]
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
[ISO-abbreviation]
Gastric Cancer
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0H43101T0J / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
86.
Santini D, Fratto ME, Spoto C, Russo A, Galluzzo S, Zoccoli A, Vincenzi B, Tonini G:
Cetuximab in small bowel adenocarcinoma: a new friend?
Br J Cancer
; 2010 Oct 12;103(8):1305; author reply 1306
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[Title]
Cetuximab in
small
bowel
adenocarcinoma
: a new friend?
[MeSH-major]
Adenocarcinoma
/ therapy. Antibodies, Monoclonal / therapeutic use.
Intestinal
Neoplasms / therapy
[MeSH-minor]
Antibodies, Monoclonal, Humanized. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cetuximab. Combined Modality Therapy. Female. Humans. Immunotherapy.
Intestine
,
Small
/ pathology. Male. Middle Aged. Survival
Hazardous Substances Data Bank.
CETUXIMAB
.
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[Cites]
Int J Cancer. 1997 Feb 7;70(4):390-5
[
9033644.001
]
[Cites]
Am J Clin Oncol. 2006 Jun;29(3):225-31
[
16755174.001
]
[Cites]
CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49
[
19474385.001
]
[Cites]
Br J Cancer. 2010 Jan 5;102(1):144-50
[
19935793.001
]
[Cites]
Curr Opin Oncol. 2010 Jul;22(4):387-93
[
20485170.001
]
[CommentOn]
Br J Cancer. 2010 Jan 5;102(1):144-50
[
19935793.001
]
(PMID = 20842127.001).
[ISSN]
1532-1827
[Journal-full-title]
British journal of cancer
[ISO-abbreviation]
Br. J. Cancer
[Language]
eng
[Publication-type]
Case Reports; Comment; Evaluation Studies; Letter
[Publication-country]
England
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 7673326042 / irinotecan; PQX0D8J21J / Cetuximab; XT3Z54Z28A / Camptothecin
[Other-IDs]
NLM/ PMC2967067
87.
Trikudanathan G, Dasanu CA:
Evolving pharmacotherapeutic strategies for small bowel adenocarcinoma.
Expert Opin Pharmacother
; 2010 Jul;11(10):1695-704
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[Title]
Evolving pharmacotherapeutic strategies for
small
bowel
adenocarcinoma
.
IMPORTANCE OF THE FIELD: Owing to nonspecific signs and symptoms, the majority of patients with
small
bowel
adenocarcinoma
(SBA) present with advanced-stage disease.
[MeSH-major]
Adenocarcinoma
/ drug therapy.
Intestinal
Neoplasms / drug therapy.
Intestine
,
Small
/ pathology
Hazardous Substances Data Bank.
FLUOROURACIL
.
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(PMID = 20446863.001).
[ISSN]
1744-7666
[Journal-full-title]
Expert opinion on pharmacotherapy
[ISO-abbreviation]
Expert Opin Pharmacother
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
England
[Chemical-registry-number]
7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
[Number-of-references]
48
88.
Sameshima S, Tomozawa S, Koketsu S, Okada T, Miyato H, Iijima M, Kojima M, Kaji T:
Intramucosal adenocarcinoma of the ileum originated 40 years after ileosigmoidostomy.
World J Surg Oncol
; 2009;7:41
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[Title]
Intramucosal
adenocarcinoma of
the ileum originated 40 years after ileosigmoidostomy.
BACKGROUND:
Small
bowel adenocarcinomas
(SBAs) are rare carcinomas.
A mucosal biopsy specimen showed
adenocarcinoma
histopathologically.
Histological examination revealed a well differentiated intramucosal
adenocarcinoma
(
adenocarcinoma
in situ).
Immunohistological staining demonstrated the overexpression of p53 protein in the
adenocarcinoma
.
CONCLUSION:
Adenocarcinoma of
the ileum at such an early stage is a very rare event.
In this case, there is a possibility that the ileosigmoidostomy resulted in a back flow of colonic stool to the ileum that caused the carcinogenesis of the
small intestine
.
[MeSH-major]
Adenocarcinoma
/ etiology. Appendicitis / surgery. Colon, Sigmoid / surgery. Ileal Neoplasms / etiology. Ileostomy / adverse effects. Postoperative Complications / etiology
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[Cites]
Int J Colorectal Dis. 2003 May;18(3):276-8
[
12785331.001
]
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Dis Colon Rectum. 2002 Nov;45(11):1496-502
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[Cites]
Am J Gastroenterol. 2003 Jun;98(6):1423-7
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12818291.001
]
(PMID = 19379525.001).
[ISSN]
1477-7819
[Journal-full-title]
World journal of surgical oncology
[ISO-abbreviation]
World J Surg Oncol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC2676285
89.
Roy P, Kumar D:
Strictureplasty for active Crohn's disease.
Int J Colorectal Dis
; 2006 Jul;21(5):427-32
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METHODS: A retrospective review of 14 patients who underwent strictureplasty either in isolation or in combination with limited resection for active
small
bowel
Crohn's disease between 1996 and 2004 was undertaken.
There was no operative mortality; however, one patient subsequently died from metastatic
small
bowel
adenocarcinoma
arising from existing Crohn's disease.
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10910235.001
]
(PMID = 16133000.001).
[ISSN]
0179-1958
[Journal-full-title]
International journal of colorectal disease
[ISO-abbreviation]
Int J Colorectal Dis
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
90.
Watermeyer G, Locketz M, Govender D, Mall A:
Crohn's disease-associated small bowel adenocarcinoma with pre-existing low-grade dysplasia: a case report.
Am J Gastroenterol
; 2007 Jul;102(7):1545-6
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[Title]
Crohn's disease-associated
small
bowel
adenocarcinoma
with pre-existing low-grade dysplasia: a case report.
[MeSH-major]
Adenocarcinoma
/ pathology. Crohn Disease / pathology. Ileal Neoplasms / pathology. Precancerous Conditions
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(PMID = 17593171.001).
[ISSN]
0002-9270
[Journal-full-title]
The American journal of gastroenterology
[ISO-abbreviation]
Am. J. Gastroenterol.
[Language]
eng
[Publication-type]
Case Reports; Letter
[Publication-country]
United States
91.
Husain S, Thompson D, Thomas L, Donaldson B, Sabbagh R:
Adnexal mass: an unusual presentation of small-bowel adenocarcinoma.
J Natl Med Assoc
; 2006 May;98(5):799-802
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[Title]
Adnexal mass: an unusual presentation
of small
-
bowel
adenocarcinoma
.
Malignancy of the
small
bowel
presents unique diagnostic and therapeutic challenges resulting in a delayed
diagnosis
in many cases.
Small
-
bowel
tumors respond poorly to most forms of treatment.
Metastatic lesions to the ovaries comprise a
small
percentage of all ovarian malignant neoplasms.
Ovarian metastases from primary
small
-
bowel
tumors are often difficult to differentiate from primary ovarian tumors.
Only few reports have described ovarian metastases from
small
-
bowel
sources.
A high index of suspicion can lead to an earlier
diagnosis
and can have an impact on the therapeutic options as well as the survival of the patients.
[MeSH-major]
Adenocarcinoma
/
diagnosis
. Adnexal Diseases /
diagnosis
.
Intestinal
Neoplasms /
diagnosis
.
Intestine
,
Small
/ pathology
[MeSH-minor]
Abdominal Pain.
Diagnosis
, Differential. Female. Humans. Middle Aged
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[Cites]
Gynecol Oncol. 2000 Aug;78(2):255-8
[
10926813.001
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[Cites]
Am J Surg Pathol. 1987 Feb;11(2):114-21
[
3812871.001
]
(PMID = 16749659.001).
[ISSN]
1943-4693
[Journal-full-title]
Journal of the National Medical Association
[ISO-abbreviation]
J Natl Med Assoc
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ PMC2569296
92.
Diosdado B, Buffart TE, Watkins R, Carvalho B, Ylstra B, Tijssen M, Bolijn AS, Lewis F, Maude K, Verbeke C, Nagtegaal ID, Grabsch H, Mulder CJ, Quirke P, Howdle P, Meijer GA:
High-resolution array comparative genomic hybridization in sporadic and celiac disease-related small bowel adenocarcinomas.
Clin Cancer Res
; 2010 Mar 1;16(5):1391-401
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[Title]
High-resolution array comparative genomic hybridization in sporadic and celiac disease-related
small
bowel adenocarcinomas
.
PURPOSE: The molecular pathogenesis
of small
intestinal adenocarcinomas
is not well understood.
Understanding the molecular characteristics
of small
bowel
adenocarcinoma
may lead to more effective patient treatment.
EXPERIMENTAL DESIGN: Forty-eight
small
bowel adenocarcinomas
(33 non-celiac disease related and 15 celiac disease related) were characterized for chromosomal aberrations by high-resolution array comparative hybridization, microsatellite instability, and APC promoter methylation and mutation status.
Furthermore, molecular alterations were compared between celiac disease-related and non-celiac disease-related
small
bowel adenocarcinomas
.
RESULTS: DNA copy number changes were observed in 77%
small
bowel adenocarcinomas
.
Celiac disease-related and non-celiac disease-related
small
bowel adenocarcinomas
displayed similar chromosomal aberrations.
Promoter hypermethylation of the APC gene was found in 48% non-celiac disease-related and 73% celiac disease-related
small
bowel adenocarcinomas
.
Thirty-three percent of non-celiac disease-related
small
bowel adenocarcinomas
showed microsatellite instability, whereas 67% of celiac disease-related
small
bowel adenocarcinomas
were microsatellite unstable.
CONCLUSIONS: Our study characterized chromosomal aberrations and amplifications involved in
small
bowel
adenocarcinoma
.
At the chromosomal level, celiac disease-related and non-celiac disease-related
small
bowel adenocarcinomas
did not differ.
A defect in the mismatch repair pathways seems to be more common in celiac disease-related than in non-celiac disease-related
small
bowel adenocarcinomas
.
In contrast to colon and gastric cancers, no APC nonsense mutations were found in
small
bowel
adenocarcinoma
.
However, APC promoter methylation seems to be a common event in celiac disease-related
small
bowel
adenocarcinoma
.
[MeSH-major]
Adenocarcinoma
/ genetics. Celiac Disease / complications.
Intestinal
Neoplasms / genetics
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(PMID = 20179237.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
93.
Okubo K, Yoshioka S, Asukai K, Hata T, Nakanishi M, Maekawa T, Hama N, Kashiwazaki M, Taniguchi M, Tsujie M, Konishi M, Yano K, Fujimoto T:
[A case report of primary adenocarcinoma of small intestine].
Gan To Kagaku Ryoho
; 2010 Nov;37(12):2792-4
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[Title]
[A case report of primary
adenocarcinoma of small intestine
].
This is an account of a case of primary
adenocarcinoma of
the
small intestine
with peritoneal dissemination successfully treated with chemotherapy.
Abdominal computerized tomography revealed a
bowel
obstruction with tumor and the remarkable
small
bowel
dilation of oral side of tumor.
Pathological
diagnosis
of the resected specimen was
adenocarcinoma
with lymph nodes metastasis.
The peritoneal dissemination consisted of metastatic
adenocarcinoma
from
small intestine
.
Primary
small
intestinal
adenocarcinoma
is a rare disease, and it is often diagnosed as advanced cancer because of few characteristic symptoms.
So carcinoma of the
small intestine
usually has a poor prognosis.
[MeSH-major]
Adenocarcinoma
/ therapy.
Intestinal
Neoplasms / therapy
Hazardous Substances Data Bank.
FLUOROURACIL
.
Hazardous Substances Data Bank.
LEUCOVORIN
.
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(PMID = 21224715.001).
[ISSN]
0385-0684
[Journal-full-title]
Gan to kagaku ryoho. Cancer & chemotherapy
[ISO-abbreviation]
Gan To Kagaku Ryoho
[Language]
jpn
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Organoplatinum Compounds; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 2S9ZZM9Q9V / Bevacizumab; 5VT6420TIG / Oxonic Acid; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
94.
Baichi MM, Arifuddin RM, Mantry PS:
Metachronous small bowel adenocarcinomas detected by capsule endoscopy in a patient with hereditary nonpolyposis colorectal cancer.
Dig Dis Sci
; 2007 Apr;52(4):1134-6
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[Title]
Metachronous
small
bowel adenocarcinomas
detected by capsule endoscopy in a patient with hereditary nonpolyposis colorectal cancer.
[MeSH-major]
Adenocarcinoma
/
diagnosis
. Capsule Endoscopy. Colorectal Neoplasms, Hereditary Nonpolyposis / pathology. Duodenal Neoplasms /
diagnosis
. Endoscopy, Gastrointestinal. Jejunal Neoplasms /
diagnosis
. Neoplasms, Second Primary /
diagnosis
Genetic Alliance.
consumer health - Colorectal Cancer
.
Genetic Alliance.
consumer health - Hereditary Cancer
.
MedlinePlus Health Information.
consumer health - Intestinal Cancer
.
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[Cites]
Clin Gastroenterol Hepatol. 2005 May;3(5):411-22
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]
(PMID = 17342393.001).
[ISSN]
0163-2116
[Journal-full-title]
Digestive diseases and sciences
[ISO-abbreviation]
Dig. Dis. Sci.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
95.
Speranza G, Doroshow JH, Kummar S:
Adenocarcinoma of the small bowel: changes in the landscape?
Curr Opin Oncol
; 2010 Jul;22(4):387-93
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[Title]
Adenocarcinoma of
the
small
bowel
: changes in the landscape?
PURPOSE OF REVIEW:
Small
bowel
adenocarcinoma
(SBA) is a rare cancer with a poor prognosis and little information to guide its management.
RECENT FINDINGS: Recent advances in less invasive imaging tools may permit earlier and increased
diagnosis
of SBA.
SUMMARY: The rarity of the disease and difficulty in
diagnosis
contribute to the lack of prospective trials evaluating therapies for SBA.
[MeSH-major]
Adenocarcinoma
/ drug therapy.
Adenocarcinoma
/ surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Intestine
,
Small
/ drug effects.
Intestine
,
Small
/ surgery
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(PMID = 20485170.001).
[ISSN]
1531-703X
[Journal-full-title]
Current opinion in oncology
[ISO-abbreviation]
Curr Opin Oncol
[Language]
eng
[Grant]
United States / Intramural NIH HHS / /
[Publication-type]
Journal Article; Research Support, N.I.H., Intramural; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 2S9ZZM9Q9V / Bevacizumab; B76N6SBZ8R / gemcitabine
[Number-of-references]
43
96.
Stucchi AF, Aarons CB, Becker JM:
Surgical approaches to cancer in patients who have inflammatory bowel disease.
Gastroenterol Clin North Am
; 2006 Sep;35(3):641-73
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[Title]
Surgical approaches to cancer in patients who have inflammatory
bowel
disease.
The absolute number of patients that develops such malignancies is low compared with the overall cancer rate; however, younger age of onset, higher relative risk, unique clinical presentations, and problems with early
diagnosis
make this a serious complication of IBD.
The prognosis remains poor for
small
bowel adenocarcinomas
in patients who have CD, primarily because of their advanced stage at detection.
Better surveillance techniques for
small
bowel
dysplasia or malignancy in patients who have CD is needed, especially given the poor prognosis of these patients when advanced cancers are detected.
Depending on the presentation and disease
diagnosis
, patients have several surgical treatment options and can expect good outcomes for all.
Surgical therapy is based not only on general oncologic principles, but also on the surgery that is appropriate for the IBD
diagnosis
.
[MeSH-major]
Colonic Neoplasms / surgery. Inflammatory
Bowel
Diseases / surgery
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(PMID = 16952745.001).
[ISSN]
0889-8553
[Journal-full-title]
Gastroenterology clinics of North America
[ISO-abbreviation]
Gastroenterol. Clin. North Am.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
144
97.
Westbrook AM, Szakmary A, Schiestl RH:
Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models.
Mutat Res
; 2010 Jul-Sep;705(1):40-59
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[Title]
Mechanisms of
intestinal
inflammation and development of associated cancers: lessons learned from mouse models.
Here we focus on
intestinal
inflammation and its associated cancers, a group of diseases on the rise and affecting millions of people worldwide.
Intestinal
inflammation can be widely grouped into inflammatory
bowel
diseases (ulcerative colitis and Crohn's disease) and celiac disease.
Long-standing
intestinal
inflammation is associated with colorectal cancer and
small
-
bowel
adenocarcinoma
, as well as extraintestinal manifestations, including lymphomas and autoimmune diseases.
This article highlights potential mechanisms of pathogenesis in inflammatory
bowel
diseases and celiac disease, as well as those involved in the progression to associated cancers, most of which have been identified from studies utilizing mouse models of
intestinal
inflammation.
Mouse models of
intestinal
inflammation can be widely grouped into chemically induced models; genetic models, which make up the bulk of the studied models; adoptive transfer models; and spontaneous models.
Studies in these models have lead to the understanding that persistent antigen exposure in
the intestinal
lumen, in combination with loss of epithelial barrier function, and dysfunction and dysregulation of the innate and adaptive immune responses lead to chronic
intestinal
inflammation.
MedlinePlus Health Information.
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.
Mouse Genome Informatics (MGI).
Mouse Genome Informatics (MGI)
.
The Lens.
Cited by Patents in
.
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[Copyright]
2010 Elsevier B.V. All rights reserved.
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(PMID = 20298806.001).
[ISSN]
0027-5107
[Journal-full-title]
Mutation research
[ISO-abbreviation]
Mutat. Res.
[Language]
ENG
[Grant]
United States / NIEHS NIH HHS / ES / ES009519-11; United States / NIEHS NIH HHS / ES / R01 ES009519; United States / NIEHS NIH HHS / ES / ES09519; United States / NIEHS NIH HHS / ES / R01 ES009519-11
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
[Publication-country]
Netherlands
[Number-of-references]
265
[Other-IDs]
NLM/ NIHMS188207; NLM/ PMC2878867
98.
Overman MJ, Pozadzides J, Kopetz S, Wen S, Abbruzzese JL, Wolff RA, Wang H:
Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine.
Br J Cancer
; 2010 Jan 5;102(1):144-50
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[Title]
Immunophenotype and molecular characterisation
of adenocarcinoma
of the
small intestine
.
BACKGROUND: Despite having a dramatically larger surface area than the large
intestine
, the
small intestine
is an infrequent site for the development
of adenocarcinoma
.
To better understand the molecular abnormalities in
small
bowel
adenocarcinoma
(SBA), we characterised a number of candidate oncogenic pathways and the immunophenotype of this rare cancer.
CONCLUSIONS: These results suggest that alterations in DNA MMR pathways are common in SBAs, similar to what is observed in large
bowel adenocarcinomas
.
[MeSH-major]
Adenocarcinoma
/ genetics. Duodenal Neoplasms / genetics. Gene Expression Profiling. Immunophenotyping. Neoplasm Proteins / biosynthesis. Oncogenes
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