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[Title] Small intestinal adenocarcinoma in common marmosets (Callithrix jacchus).

Small intestinal adenocarcinomas are uncommon neoplasms that are rarely reported in nonhuman primates.

Herein the authors report the clinical, histologic, immunohistochemical, and molecular characteristics of small intestinal adenocarcinoma in 10 common marmosets (Callithrix jacchus).

Retrospective analysis of necropsy records revealed small intestinal carcinoma to be the most common neoplastic cause of morbidity and mortality in aged common marmosets.

Nine of 10 (90%) tumors arose within the proximal small intestine near the interface with the duodenum.

No Helicobacter-like bacteria were observed via silver stain, and callitrichine herpesvirus 3 was detected by polymerase chain reaction with equal frequency from neoplastic and nonneoplastic intestinal sections.

The tumors described in this population illustrate comparable features to human cases of small intestine carcinoma and may serve as a potential animal model for small intestinal carcinomas.

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(PMID = 20460447.001).

[ISSN] 1544-2217

[Journal-full-title] Veterinary pathology

[ISO-abbreviation] Vet. Pathol.

[Language] ENG

[Grant] United States / NCRR NIH HHS / RR / T32 RR007000-35; United States / NCRR NIH HHS / RR / P51 RR000168-50; United States / NCRR NIH HHS / RR / T32 RR007000; United States / NCRR NIH HHS / RR / RR00168; United States / NCRR NIH HHS / RR / P51 RR000168; United States / NCRR NIH HHS / RR / K26 RR000168; United States / NCRR NIH HHS / RR / RR07000

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / DNA, Neoplasm

[Other-IDs] NLM/ NIHMS235944; NLM/ PMC2955325

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Recent advances in the management of adenocarcinoma of the small intestine.

Adenocarcinoma of the small intestine is a rare malignancy with limited data available to guide therapeutic decisions.

Delays in diagnosis are frequent and the majority of patients will present with advanced-stage disease and either lymph node involvement or distant metastatic disease.

Recent retrospective and prospective studies have helped to clarify the optimal chemotherapy approach for advanced small bowel adenocarcinoma.

This article reviews the clinical features and evaluation of patients with small bowel adenocarcinoma and focuses on recent advances in management.

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(PMID = 19626152.001).

[ISSN] 1934-7820

[Journal-full-title] Gastrointestinal cancer research : GCR

[ISO-abbreviation] Gastrointest Cancer Res

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2713134

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma.

Small intestinal adenocarcinoma is an uncommon neoplasm morphologically similar to or indistinguishable from colorectal adenocarcinoma.

Although much has been learned about genetic pathways critical to colorectal tumorigenesis, little is known about molecular alterations involved in the development of small intestinal adenocarcinoma.

In this study, we immunohistochemically compared non-ampullary small intestinal adenocarcinomas with sporadic colorectal adenocarcinomas for the expression of several proteins known to serve pivotal roles in colorectal tumorigenesis.

The results show that complete loss of adenomatous polyposis coli immunoreactivity, presumably resulting from its gene mutations, was observed in eight of 26 (31%) small intestinal adenocarcinomas and 36 of 51 (71%) colorectal adenocarcinomas (P = 0.0008).

Nuclear localization of beta-catenin, an indirect evidence of deregulated Wnt signaling pathway, was observed in 5 (19%) small intestinal adenocarcinomas and 36 (71%) colorectal adenocarcinomas (P<0.0001).

Total lack of nuclear staining for one or more of the DNA mismatch repair enzymes occurred in a similar low frequency in both small intestinal and colorectal adenocarcinomas, seen in two of 25 (8%) and 10 of 47 (21%) cases, respectively (P = 0.1958).

The frequencies of aberrant p53 and RB expression were also similar between small intestinal and colorectal adenocarcinomas.

These observations indicate that defects in the Wnt and microsatellite instability pathways occur in over 90% of colorectal adenocarcinomas, but in only 40% of small intestinal adenocarcinomas.

Small intestinal tumorigenesis appears to follow a distinct, yet unidentified, molecular pathway(s) from its colorectal counterpart despite their morphologic similarity.

[MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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(PMID = 16501564.001).

[ISSN] 0893-3952

[Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

[ISO-abbreviation] Mod. Pathol.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Retinoblastoma Protein; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin

   

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Small bowel adenocarcinoma in Crohn's disease: a case report and review of literature.

Small bowel adenocarcinomas are remarkable for their rarity, difficult diagnosis and poor prognosis.

Here we report an unusual case of a 33-year-old patient in whom infiltrative adenocarcinoma of the small bowel was diagnosed after a 10-year history of Crohn's disease.

In most previously reported cases, detection of Crohn's disease was subsequent to that of carcinoma of the small bowel or the patients involved had an even longer history of the disease.

Our literature review suggests that the risk of small bowel adenocarcinoma is higher in patients with Crohn's disease than in the overall population.

[MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Crohn Disease / complications. Crohn Disease / diagnosis. Ileal Neoplasms / complications. Ileal Neoplasms / diagnosis

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(PMID = 16534894.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] China

[Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 4Q81I59GXC / Mesalamine; MRK240IY2L / Azathioprine

[Number-of-references] 60

[Other-IDs] NLM/ PMC4124452

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway.

Celiac disease (CD) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma.

We hypothesized that CIM may link CD to small bowel carcinogenesis.

We determined microsatellite instability (MSI), CIM, and expression of MLH1 and MGMT in 3 CD-associated small bowel carcinomas and corresponding non-neoplastic mucosa.

The results were compared to those of small bowel mucosa from CD patients without carcinoma and 20 small bowel carcinomas from a non-CD origin.

In conclusion, our data reveal that the high-level CIM/MSI pathway is typical of CD-associated small bowel carcinomas and indicate that aberrant CpG island methylation links CD and carcinogenesis.

The data further suggest that CD should be considered in patients with small bowel adenocarcinoma, particularly when the tumors display MSI.

[MeSH-major] Adenocarcinoma / genetics. Celiac Disease / genetics. CpG Islands. DNA Methylation. Intestinal Neoplasms / genetics. Microsatellite Instability

[MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adult. Aged. Aged, 80 and over. Cohort Studies. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Humans. Intestinal Mucosa / metabolism. Intestinal Mucosa / pathology. Intestine, Small / metabolism. Intestine, Small / pathology. Male. Middle Aged. Nuclear Proteins / genetics. Signal Transduction / genetics. Tumor Suppressor Proteins / genetics

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(PMID = 21042749.001).

[ISSN] 1791-2431

[Journal-full-title] Oncology reports

[ISO-abbreviation] Oncol. Rep.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A single-institution experience with 491 cases of small bowel adenocarcinoma.

BACKGROUND: The optimal treatment of small bowel adenocarcinoma is unknown.

METHODS: The records of 491 patients with small bowel adenocarcinoma diagnosis between 1970 and 2005 were reviewed for patient and tumor characteristics, treatment effects, and survival.

RESULTS: The median age at diagnosis was 62 years.

CONCLUSIONS: The prognosis of patients with small bowel adenocarcinoma is poor.

[MeSH-major] Adenocarcinoma / surgery. Intestinal Neoplasms / surgery. Intestine, Small

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[Copyright] Published by Elsevier Inc.

(PMID = 20609724.001).

[ISSN] 1879-1883

[Journal-full-title] American journal of surgery

[ISO-abbreviation] Am. J. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Small intestinal adenocarcinoma in Peutz-Jeghers syndrome.

Peutz-Jeghers syndrome (PJS) is characterized by intestinal hamartomatous polyposis (usually affecting the jejunum) and mucocutaneous melanin spots.

We report a 25-year-old man with PJS who developed small intestinal adenocarcinoma and presented with small bowel obstruction due to jejuno-ileal intussusception.

[MeSH-major] Adenocarcinoma / etiology. Jejunal Neoplasms / etiology. Peutz-Jeghers Syndrome / complications

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(PMID = 16567896.001).

[ISSN] 0254-8860

[Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

[ISO-abbreviation] Indian J Gastroenterol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] India

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adnexal mass: an unusual presentation of small-bowel adenocarcinoma.

Malignancy of the small bowel presents unique diagnostic and therapeutic challenges resulting in a delayed diagnosis in many cases.

Small-bowel tumors respond poorly to most forms of treatment.

Metastatic lesions to the ovaries comprise a small percentage of all ovarian malignant neoplasms.

Ovarian metastases from primary small-bowel tumors are often difficult to differentiate from primary ovarian tumors.

Only few reports have described ovarian metastases from small-bowel sources.

A high index of suspicion can lead to an earlier diagnosis and can have an impact on the therapeutic options as well as the survival of the patients.

[MeSH-major] Adenocarcinoma / diagnosis. Adnexal Diseases / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small / pathology

[MeSH-minor] Abdominal Pain. Diagnosis, Differential. Female. Humans. Middle Aged

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(PMID = 16749659.001).

[ISSN] 1943-4693

[Journal-full-title] Journal of the National Medical Association

[ISO-abbreviation] J Natl Med Assoc

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2569296

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Lack of HER2 overexpression and amplification in small intestinal adenocarcinoma.

HER2 overexpression and amplification have been studied as a therapeutic and prognostic target in a number of human cancers, including esophageal, gastric, and colorectal adenocarcinomas.

However, HER2 status has not been well investigated in primary small intestinal adenocarcinoma, probably because of its rarity.

In this study, we conducted immunohistochemical analysis and fluorescence in situ hybridization (FISH) for HER2 on 49 primary nonampullar small intestinal adenocarcinomas.

These observations demonstrate that HER2 protein overexpression and gene amplification are infrequent events, if they occur at all, in small intestinal adenocarcinoma.

Thus, routine immunohistochemical and/or FISH testing for HER2 for potential targeted anti-HER2 therapy may not be beneficial for patients with primary small intestinal adenocarcinoma.

[MeSH-major] Adenocarcinoma / metabolism. Gene Amplification. Intestinal Neoplasms / metabolism. Intestine, Small / metabolism. Receptor, ErbB-2 / metabolism

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(PMID = 21088150.001).

[ISSN] 1943-7722

[Journal-full-title] American journal of clinical pathology

[ISO-abbreviation] Am. J. Clin. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma.

We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male.

Adenocarcinoma without stromal invasion was observed adjacent to the small intestinal mucosa.

Immunohistochemistry of the adenocarcinoma tissue revealed p53 overexpression and high Ki-67 labeling index as well as positive staining for CD10, cytokeratin 7, and cytokeratin 20.

Therefore, the diagnosis of small intestinal adenocarcinoma was made.

To our knowledge, this is the first case of small intestinal adenocarcinoma arising in retroperitoneal mature cystic teratoma.

A unique feature of this case is that malignant transformation in retroperitoneal mature teratoma arose even in the fully developed intestine.

[MeSH-major] Adenocarcinoma / pathology. Neoplasms, Multiple Primary / pathology. Retroperitoneal Neoplasms / pathology. Teratoma / pathology

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[Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.

[ErratumIn] Pathol Int. 2010 Dec;60(12):798

(PMID = 20846270.001).

[ISSN] 1440-1827

[Journal-full-title] Pathology international

[ISO-abbreviation] Pathol. Int.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Australia

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Expression of mucins, SIMA, villin, and CDX2 in small-intestinal adenocarcinoma.

Expression of gastrointestinal biomarkers MUC1, MUC2, MUC5AC, small-intestinal mucin antigen (SIMA), villin, and CDX2 has been studied in colorectal adenocarcinoma (CRC).

Little is known, however, about their expression in small-intestinal adenocarcinoma (SIA).

[MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Intestinal Neoplasms / metabolism. Intestine, Small / metabolism. Neoplasm Proteins / metabolism

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(PMID = 17951204.001).

[ISSN] 0002-9173

[Journal-full-title] American journal of clinical pathology

[ISO-abbreviation] Am. J. Clin. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Microfilament Proteins; 0 / Mucins; 0 / Neoplasm Proteins; 0 / gastro-intestinal mucus-associated antigens; 0 / villin

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Impact of lymph node evaluation on survival for small bowel adenocaricnoma: Analysis of the Surveillance, Epidemiology and End Results (SEER) database.

: 4596 Background: Small bowel adenocarcinoma is a rare malignancy and is often associated with poor outcome.

METHODS: Patients aged 18-90 with adenocarcinoma of the small intestine diagnosed between 1988 and 2005 were identified from SEER data (ver. 2008).

CONCLUSIONS: As noted in colon cancer, the total number of LN assessed has considerable influence upon survival in stage I, II and III small bowel adenocarcinoma.

Stratifying stage III small bowel adenocarcinoma into those with <3 and ≥3 positive lymph nodes significantly improves prognostication for these patients and future staging systems should incorporate the number of positive nodes into nodal staging.

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(PMID = 27963112.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Chemotherapeutic management of small bowel adenocarcinoma associated with Crohn's disease.

Four patients with metastatic primary small bowel adenocarcinoma associated with Crohn's disease were successfully treated with low dose combination chemotherapy consisting of 5-fluorouracil, leucovorin and irinotecan with or without gemcitabine.

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Crohn Disease / complications. Duodenal Neoplasms / drug therapy. Ileal Neoplasms / drug therapy. Jejunal Neoplasms / drug therapy

[MeSH-minor] Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Female. Humans. Intestine, Small / pathology. Leucovorin / administration & dosage. Male. Remission Induction. Survival Analysis

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(PMID = 17127233.001).

[ISSN] 1120-009X

[Journal-full-title] Journal of chemotherapy (Florence, Italy)

[ISO-abbreviation] J Chemother

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

[Chemical-registry-number] 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; XT3Z54Z28A / Camptothecin

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma.

Small bowel adenocarcinoma is a rare etiology for PC.

METHODS: From a prospective database of IPHC patients, six patients diagnosed with PC from adenocarcinoma of the small bowel were identified.

Median survival after diagnosis of small bowel adenocarcinoma was 54 months, while median survival after CS and IPHC for PC was 30.1 months.

CONCLUSIONS: Small bowel adenocarcinoma with PC remains an unusual therapeutic challenge.

[MeSH-major] Adenocarcinoma / drug therapy. Hyperthermia, Induced. Ileal Neoplasms / drug therapy. Jejunal Neoplasms / drug therapy. Peritoneal Neoplasms / drug therapy

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[Copyright] Copyright 2005 Wiley-Liss, Inc.

(PMID = 16028284.001).

[ISSN] 0022-4790

[Journal-full-title] Journal of surgical oncology

[ISO-abbreviation] J Surg Oncol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy.

Small bowel adenocarcinoma (SBA) in patients with Crohn's disease (CD) is quite rare, difficult to diagnose without surgery, and has a poor prognosis.

PET/CT detected an accumulation spot in the small bowel.

An endoscopic forceps biopsy specimen showed poorly differentiated adenocarcinoma.

There were some longitudinal ulcer scars near the tumor, and the chronic inflammation in the small bowel appeared to be associated with the cancer development.

Since early diagnosis is extremely difficult in these cases, novel techniques, such as PET/CT and DBE, may be expected to help in making a preoperative diagnosis of the development of SBA in CD.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / etiology. Crohn Disease / complications. Endoscopy, Gastrointestinal / methods. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / etiology. Intestine, Small / pathology

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[Cites] Gut. 2001 Apr;48(4):526-35 [11247898.001]

[Cites] Cancer. 2001 Feb 15;91(4):854-62 [11241255.001]

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(PMID = 19360924.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] China

[Other-IDs] NLM/ PMC2668786

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pathogenesis and risk factors of small bowel adenocarcinoma: a colorectal cancer sibling?

Small bowel adenocarcinoma (SBA) is a very rare entity accounting for one-fourth of the small intestine neoplasms.

It appears that SBA shares several genetic characteristics with large bowel tumors, but also has unique features.

[MeSH-major] Adenocarcinoma / etiology. Intestinal Neoplasms / etiology. Intestine, Small

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(PMID = 15743371.001).

[ISSN] 0002-9270

[Journal-full-title] The American journal of gastroenterology

[ISO-abbreviation] Am. J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] United States

[Number-of-references] 101

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Small bowel adenocarcinoma in Crohn's disease.

Small bowel neoplastic disease is a rare but dreaded occurrence in Crohn's disease (CD) and the diagnosis is often disguised by nonspecific and varied presenting symptoms mimicking active or obstructive CD.

As such, the diagnosis is all too often delayed, typically detected at a late stage, and with a poor prognosis.

CD has become a well-recognized risk factor for the development of small bowel adenocarcinoma.

[MeSH-major] Adenocarcinoma / epidemiology. Crohn Disease / complications. Ileal Neoplasms / epidemiology. Jejunal Neoplasms / epidemiology

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(PMID = 18275076.001).

[ISSN] 1536-4844

[Journal-full-title] Inflammatory bowel diseases

[ISO-abbreviation] Inflamm. Bowel Dis.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 37

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] High-resolution array comparative genomic hybridization in sporadic and celiac disease-related small bowel adenocarcinomas.

PURPOSE: The molecular pathogenesis of small intestinal adenocarcinomas is not well understood.

Understanding the molecular characteristics of small bowel adenocarcinoma may lead to more effective patient treatment.

EXPERIMENTAL DESIGN: Forty-eight small bowel adenocarcinomas (33 non-celiac disease related and 15 celiac disease related) were characterized for chromosomal aberrations by high-resolution array comparative hybridization, microsatellite instability, and APC promoter methylation and mutation status.

Furthermore, molecular alterations were compared between celiac disease-related and non-celiac disease-related small bowel adenocarcinomas.

RESULTS: DNA copy number changes were observed in 77% small bowel adenocarcinomas.

Celiac disease-related and non-celiac disease-related small bowel adenocarcinomas displayed similar chromosomal aberrations.

Promoter hypermethylation of the APC gene was found in 48% non-celiac disease-related and 73% celiac disease-related small bowel adenocarcinomas.

Thirty-three percent of non-celiac disease-related small bowel adenocarcinomas showed microsatellite instability, whereas 67% of celiac disease-related small bowel adenocarcinomas were microsatellite unstable.

CONCLUSIONS: Our study characterized chromosomal aberrations and amplifications involved in small bowel adenocarcinoma.

At the chromosomal level, celiac disease-related and non-celiac disease-related small bowel adenocarcinomas did not differ.

A defect in the mismatch repair pathways seems to be more common in celiac disease-related than in non-celiac disease-related small bowel adenocarcinomas.

In contrast to colon and gastric cancers, no APC nonsense mutations were found in small bowel adenocarcinoma.

However, APC promoter methylation seems to be a common event in celiac disease-related small bowel adenocarcinoma.

[MeSH-major] Adenocarcinoma / genetics. Celiac Disease / complications. Intestinal Neoplasms / genetics

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(PMID = 20179237.001).

[ISSN] 1078-0432

[Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research

[ISO-abbreviation] Clin. Cancer Res.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases.

BACKGROUND: Small bowel adenocarcinoma is a rare cancer that has generally been considered resistant to chemotherapy, although little has been published on the role of chemotherapy.

A retrospective analysis was conducted of patients with advanced small bowel adenocarcinoma to explore chemotherapy use, and gain knowledge for ongoing management and future clinical trials.

PATIENTS AND METHODS: All patients with advanced adenocarcinoma of the small bowel treated at Princess Margaret Hospital (PMH) between 1986 and 2004 were identified through the cancer registry.

CONCLUSION: Chemotherapy appears to have activity in adenocarcinoma of the small bowel.

[MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestinal Neoplasms / pathology

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(PMID = 16755174.001).

[ISSN] 1537-453X

[Journal-full-title] American journal of clinical oncology

[ISO-abbreviation] Am. J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] 'Metachronous' adenocarcinoma of the small intestine.

Adenocarcinoma of the small intestine accounts for less than 1% of primary gastrointestinal malignancies (1).

Small intestine contains 75% of the length of the gastrointestinal tract with 90% of the surface mucosal area, and yet carcinoma is rare.

Symptoms of small bowel adenocarcinoma are vague and non-specific, and this region is relatively inaccessible which together contributes to their late diagnosis and poor prognosis.

The authors report a case of two primary adenocarcinomas of the small intestine in the same patient.

[MeSH-major] Adenocarcinoma / radiography. Jejunal Neoplasms / radiography. Neoplasms, Second Primary / radiography

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(PMID = 15875642.001).

[ISSN] 1368-504X

[Journal-full-title] International journal of clinical practice. Supplement

[ISO-abbreviation] Int J Clin Pract Suppl

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine.

BACKGROUND: Despite having a dramatically larger surface area than the large intestine, the small intestine is an infrequent site for the development of adenocarcinoma.

To better understand the molecular abnormalities in small bowel adenocarcinoma (SBA), we characterised a number of candidate oncogenic pathways and the immunophenotype of this rare cancer.

CONCLUSIONS: These results suggest that alterations in DNA MMR pathways are common in SBAs, similar to what is observed in large bowel adenocarcinomas.

[MeSH-major] Adenocarcinoma / genetics. Duodenal Neoplasms / genetics. Gene Expression Profiling. Immunophenotyping. Neoplasm Proteins / biosynthesis. Oncogenes

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(PMID = 19935793.001).

[ISSN] 1532-1827

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase

[Other-IDs] NLM/ PMC2813754

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Retained capsule endoscope leading to the identification of small bowel adenocarcinoma in a patient with undiagnosed Crohn disease.

Small intestinal neoplasia is a rare condition that frequently presents a diagnostic challenge.

We describe the case of a 70-year-old patient who presented with several years of chronic, intermittent abdominal pain, previously diagnosed as irritable bowel syndrome.

Radiographic evaluation, including upper gastrointestinal series with small bowel follow-through and computed tomography, demonstrated dilated small bowel with possible strictures.

Extensive flat and polypoid high- and low-grade dysplasia were present, as well as an area of well-differentiated adenocarcinoma invading into the muscularis propria.

We discuss the epidemiology, pathogenesis, and diagnosis of small bowel malignancy.

[MeSH-major] Adenocarcinoma / diagnosis. Capsule Endoscopy. Crohn Disease / diagnosis. Ileal Neoplasms / diagnosis

[MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Aged. Humans. Male. Neoplasm Staging. Staining and Labeling. Treatment Outcome

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(PMID = 19917475.001).

[ISSN] 1532-8198

[Journal-full-title] Annals of diagnostic pathology

[ISO-abbreviation] Ann Diagn Pathol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Small bowel adenocarcinoma.

Small bowel cancers are rare, accounting for only about 6000 cases/year in the United States, approximately 25% of which are small bowel adenocarcinomas.

Small bowel adenocarcinomas have traditionally been considered to be highly fatal due to their nonspecific presentation at the time of diagnosis, and to the lack of responsiveness to older chemotherapy regimens.

Newer diagnostic techniques such as video capsule and double balloon enteroscopy may facilitate earlier diagnosis.

Still, there remains great need for multi-institutional, cooperative group studies to define the optimal treatment of small bowel adenocarcinoma, both in the adjuvant and advanced/metastatic setting.

[MeSH-major] Adenocarcinoma / epidemiology. Intestinal Neoplasms / epidemiology

[MeSH-minor] Age of Onset. Animals. Antimetabolites, Antineoplastic / therapeutic use. Disease Models, Animal. Female. Fluorouracil / therapeutic use. Humans. Intestine, Small / pathology. Male. Mice. Middle Aged. Neoplasm Staging. Prognosis. Risk Factors. United States / epidemiology

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(PMID = 19365735.001).

[ISSN] 1534-6277

[Journal-full-title] Current treatment options in oncology

[ISO-abbreviation] Curr Treat Options Oncol

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil

[Number-of-references] 40

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognosis of small bowel adenocarcinoma treated with Mayo or Xelox regimen: a matched case-control study from a database of 581 patients with colorectal cancer.

The purpose of this study was to compare the effects of chemotherapy on the prognosis for patients with adenocarcinoma of the small bowel (SBC) and colorectal cancer (CRC).

However, reliable conclusions cannot be drawn from a small patient population, and multicentre studies are needed.

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colorectal Neoplasms / drug therapy. Intestine, Small / drug effects

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(PMID = 17786369.001).

[ISSN] 1021-335X

[Journal-full-title] Oncology reports

[ISO-abbreviation] Oncol. Rep.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / Drug Combinations; 0 / Organoplatinum Compounds; 0W860991D6 / Deoxycytidine; U3P01618RT / Fluorouracil; XELOX

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Resection of small bowel adenocarcinoma liver metastasis combined with neoadjuvant and adjuvant chemotherapy results in extended disease-free period--a case report.

Small bowel adenocarcinoma (SBA) is a very rare tumor entity but occurs in up to 5% of patients suffering from familiar adenomatous polyposis (FAP).

Because of nonspecific symptoms, diagnosis is usually made with delay, which contributes to high rates of metastatic disease at the time of diagnosis.

In October 2001, a 51-year-old woman with attenuated FAP, that had total proctocolectomy in 1994 was diagnosed with a jejunal adenocarcinoma.

She subsequently underwent small bowel resection.

Afterwards, a small residual lesion in segment VIII was seen in CT scan but could not be identified by PET and at laparotomy in November 2002.

[MeSH-major] Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hepatectomy. Ileal Neoplasms / therapy. Jejunal Neoplasms / therapy. Liver Neoplasms / therapy. Neoadjuvant Therapy

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(PMID = 17827529.001).

[ISSN] 1537-3649

[Journal-full-title] International journal of gastrointestinal cancer

[ISO-abbreviation] Int J Gastrointest Cancer

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Small bowel adenocarcinoma].

[Transliterated title] Adénocarcinome de l'intestin grêle.

Small bowel adenocarcinoma is a rare tumor.

Diagnosis is usually performed at an advanced stage because of non-specific nature of clinical manifestations.

New methods of radiological and endoscopic exploration of small intestine should allow earlier diagnosis.

A national prospective cohort study is currently evaluating the results of chemotherapy (recommended protocol: FOLFOX) as adjuvant and palliative treatment of small bowel adenocarcinoma.

[MeSH-major] Adenocarcinoma / etiology. Adenocarcinoma / therapy. Intestinal Neoplasms / etiology. Intestinal Neoplasms / therapy

[MeSH-minor] Chemotherapy, Adjuvant. Genetic Predisposition to Disease. Humans. Intestine, Small / pathology. Intestine, Small / surgery. Lymphatic Metastasis. Neoplasm Metastasis. Prognosis. Risk Factors

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[Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.

(PMID = 20537487.001).

[ISSN] 0399-8320

[Journal-full-title] Gastroentérologie clinique et biologique

[ISO-abbreviation] Gastroenterol. Clin. Biol.

[Language] fre

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] France

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Coexisting malignant lymphoma of the duodenum and adenocarcinoma of the colon.

Synchronous malignant mucosa associated lymphoid tissue MALT-lymphoma of the small bowel and adenocarcinoma of the colon in the same patient is a scarce rarity.

Thus, it might be of interest to report such a case of coexisting malignant MALT-lymphoma of the duodenum and adenocarcinoma of the large bowel.

[MeSH-major] Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Duodenal Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Neoplasms, Multiple Primary / pathology

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(PMID = 17334482.001).

[ISSN] 0379-5284

[Journal-full-title] Saudi medical journal

[ISO-abbreviation] Saudi Med J

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Saudi Arabia

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic factors of primary small bowel adenocarcinoma: univariate and multivariate analysis.

BACKGROUND: Adenocarcinoma of the small bowel is relatively less common than malignancies of the esophagus, stomach, and colorectum.

In small bowel adenocarcinoma, various prognostic factors influence the disease-free status and overall survival rates.

MATERIALS AND METHODS: Eighty patients who were diagnosed with small bowel adenocarcinoma and treated at our institute between 1983 and 2003 were retrospectively reviewed.

CONCLUSIONS: Poor prognosis of small bowel adenocarcinoma may be related to a delay in the diagnosis and treatment of the disease.

Curative resection is the aim of surgical treatment for small bowel adenocarcinoma.

[MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small

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(PMID = 16479330.001).

[ISSN] 0364-2313

[Journal-full-title] World journal of surgery

[ISO-abbreviation] World J Surg

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Risk factors associated with small bowel adenocarcinoma in Crohn's disease: a case-control study.

BACKGROUND AND AIMS: It is well established that Crohn's disease (CD) is associated with an increased risk of small bowel adenocarcinoma (SBA).

METHODS: In 11 French centers affiliated with the GETAID (Groupe d'Etude Thérapeutique des Affections Inflammatoires du Tube Digestif), we identified 29 patients with CD and SBA.

RESULTS: In univariate analysis, the cases had had significantly less small bowel resection and received prolonged treatment with salicylates (more than 2 yr), less often than the controls (odds ratio, OR [95% confidence interval, CI] 0.07 [0.01-0.32] and 0.29 [0.10-0.82], respectively).

CONCLUSION: This study suggests that small bowel resection and prolonged salicylates use may protect against SBA in CD patients.

[MeSH-major] Adenocarcinoma / etiology. Crohn Disease / complications. Intestinal Neoplasms / etiology. Intestine, Small

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[CommentIn] Inflamm Bowel Dis. 2009 Sep;15(9):1434-5 [19202570.001]

(PMID = 18564124.001).

[ISSN] 1572-0241

[Journal-full-title] The American journal of gastroenterology

[ISO-abbreviation] Am. J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Salicylates

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Primary small bowel adenocarcinoma].

[Transliterated title] Adenocarcinoma primario de intestino delgado.

INTRODUCTION: Primary small bowel adenocarcinoma is an uncommon tumour, with non-specific symptoms that cause a delay in the diagnosis and consequently a worse outcome for the patient.

MATERIAL AND METHOD: We performed a retrospective study of our experience with 17 patients diagnosed with primary small bowel adenocarcinoma, excluding all the cases suggesting secondary involvement of the small bowel from an adenocarcinoma in other locations.

Those with duodenal tumours underwent 4 pancreaticoduodenectomies, 3 gastroenterostomies and 1 diagnostic biopsy; 6 bowel resections with lymphadenectomy, 2 en-bloc resections and 1 by-pass were performed on those with jejuno-ileal tumours.

CONCLUSIONS: Curative treatment consists of small bowel resection.

[MeSH-major] Adenocarcinoma. Duodenal Neoplasms. Ileal Neoplasms. Jejunal Neoplasms

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(PMID = 19344893.001).

[ISSN] 0009-739X

[Journal-full-title] Cirugía española

[ISO-abbreviation] Cir Esp

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Spain

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Primary small bowel neoplasms as a complication of celiac disease].

[Transliterated title] Neoplasias primarias de intestino delgado como complicación de la enfermedad celíaca.

The most serious complication in these patients is the development of neoplasms, the most frequent being enteropathy-associated T-cell lymphoma; however, an increase in the incidence of small bowel adenocarcinoma has also been described.

We present two cases of small bowel carcinoma in patients with celiac disease, which were diagnosed at the onset of the disease.

[MeSH-major] Adenocarcinoma / etiology. Celiac Disease / complications. Duodenal Neoplasms / etiology. Ileal Neoplasms / etiology

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(PMID = 19625106.001).

[ISSN] 0210-5705

[Journal-full-title] Gastroenterología y hepatología

[ISO-abbreviation] Gastroenterol Hepatol

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Spain

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Loss of carbamoyl phosphate synthetase I in small-intestinal adenocarcinoma.

Carbamoyl phosphate synthetase I (CPS1), normally found in hepatocytes and small-intestine (SI) enterocytes, is the antigen of Hep Par 1 antibody.

Expression of CPS1 in invasive SI adenocarcinoma seems to be lost.

We retrospectively collected 36 total specimens, which included 31 SI adenomas and 21 adenocarcinomas.

Of the 21 invasive adenocarcinomas, 15 lost antigen expression (71%).

[MeSH-major] Adenocarcinoma / enzymology. Carbamoyl-Phosphate Synthase (Ammonia) / metabolism. Duodenal Neoplasms / enzymology. Duodenum / enzymology

[MeSH-minor] Adenoma / enzymology. Adenoma / pathology. Biomarkers, Tumor / metabolism. Duodenitis / enzymology. Duodenitis / pathology. Humans. Immunohistochemistry. Intestinal Mucosa / enzymology. Intestinal Mucosa / pathology. Neoplasm Invasiveness. Retrospective Studies

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(PMID = 19926579.001).

[ISSN] 1943-7722

[Journal-full-title] American journal of clinical pathology

[ISO-abbreviation] Am. J. Clin. Pathol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; EC 6.3.4.16 / Carbamoyl-Phosphate Synthase (Ammonia)

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Evolving pharmacotherapeutic strategies for small bowel adenocarcinoma.

IMPORTANCE OF THE FIELD: Owing to nonspecific signs and symptoms, the majority of patients with small bowel adenocarcinoma (SBA) present with advanced-stage disease.

[MeSH-major] Adenocarcinoma / drug therapy. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology

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(PMID = 20446863.001).

[ISSN] 1744-7666

[Journal-full-title] Expert opinion on pharmacotherapy

[ISO-abbreviation] Expert Opin Pharmacother

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Chemical-registry-number] 7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin

[Number-of-references] 48

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [A case report of primary adenocarcinoma of small intestine].

This is an account of a case of primary adenocarcinoma of the small intestine with peritoneal dissemination successfully treated with chemotherapy.

Abdominal computerized tomography revealed a bowel obstruction with tumor and the remarkable small bowel dilation of oral side of tumor.

Pathological diagnosis of the resected specimen was adenocarcinoma with lymph nodes metastasis.

The peritoneal dissemination consisted of metastatic adenocarcinoma from small intestine.

Primary small intestinal adenocarcinoma is a rare disease, and it is often diagnosed as advanced cancer because of few characteristic symptoms.

So carcinoma of the small intestine usually has a poor prognosis.

[MeSH-major] Adenocarcinoma / therapy. Intestinal Neoplasms / therapy

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(PMID = 21224715.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Organoplatinum Compounds; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 2S9ZZM9Q9V / Bevacizumab; 5VT6420TIG / Oxonic Acid; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Small bowel adenocarcinoma is a relatively rare malignancy.

In Korea, 13.1% of small bowel adenocarcinoma occurs in the jejunum.

The absence of effective screening methods and relatively obscure symptoms contribute to the higher percentage of advanced cases at the time of diagnosis.

Chemotherapy and radiotherapy have shown a disappointing treatment result for advanced staged small bowel adenocarcinoma.

[MeSH-major] Adenocarcinoma / diagnosis. Intestinal Obstruction / diagnosis. Jejunal Neoplasms / diagnosis. Stents

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(PMID = 20664318.001).

[ISSN] 1598-9992

[Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

[ISO-abbreviation] Korean J Gastroenterol

[Language] kor

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Korea (South)

[Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Surgical management and outcome in primary adenocarcinoma of the small bowel.

BACKGROUND: Primary adenocarcinoma of the small bowel is a rare malignancy and is associated with poor survival outcome.

METHODS: Between 1971 and 2005, 64 patients with primary adenocarcinoma of the small bowel were treated at our institution.

RESULTS: The most common clinical features at presentation included abdominal pain (n = 33; 51.6%) or bowel obstruction (n = 20; 31.3%).

The most frequently involved portion of the small bowel was the duodenum (n = 41; 64%).

A segmental bowel resection was performed in 30 patients and pancreaticoduodenectomy in 14 patients.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / pathology. Intestinal Neoplasms / surgery

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(PMID = 17549572.001).

[ISSN] 1068-9265

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature.

Primary adenocarcinoma of the ileum is an uncommon gastrointestinal malignancy, the symptoms of which are often insidious in onset.

This case history highlights the previously unreported finding of ileal adenocarcinoma presenting with mucusuria, caused by local invasion of the bladder in a 44-year-old male.

A review of the literature is included to highlight the incidence, risk factors, clinical presentation, investigation, and current management of adenocarcinoma of the small bowel.

[MeSH-major] Adenocarcinoma / secondary. Ileal Neoplasms / pathology. Intestinal Fistula / diagnosis. Urinary Bladder Fistula / diagnosis. Urinary Bladder Neoplasms / secondary

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(PMID = 16119711.001).

[ISSN] 0020-8868

[Journal-full-title] International surgery

[ISO-abbreviation] Int Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic factors in primary adenocarcinoma of the small intestine: 13-year single institution experience.

BACKGROUND: Adenocarcinoma of the small bowel is a relatively rare malignancy as compared to the other malignancies of the gastrointestinal tract.

Nonspecific presentation and infrequent occurrence often leads to a delay in diagnosis and consequent poor prognosis.

METHODS: The medical records of a total of 27 patients treated for adenocarcinoma of the small bowel at Providence Hospital and Medical Centers from year 1990 through 2003 were reviewed retrospectively.

RESULTS: The patients included nine males and eighteen females with a median age at diagnosis of 62 years.

Only 48% of the patients had an accurate preoperative diagnosis while another 33% had a diagnosis suspicious of small bowel malignancy.

[MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Intestinal Neoplasms / mortality. Intestinal Neoplasms / surgery. Intestine, Small / pathology

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[Cites] Cancer. 1999 Dec 15;86(12):2693-706 [10594865.001]

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(PMID = 18237404.001).

[ISSN] 1477-7819

[Journal-full-title] World journal of surgical oncology

[ISO-abbreviation] World J Surg Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2253527

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study.

However, the coexistence of neurofibromatosis with small-bowel adenocarcinoma is exceedingly rare.

We present an uncommon case of neurofibromatosis type 1, involving the small bowel in a 73-year-old man, who was admitted to our department with signs of acute abdomen.

These nodules obstructed ileal lumen, while the intestine wall was perforated in one point.

Histology revealed neurofibromatosis type 1 with malignant transformation to small-bowel adenocarcinoma.

We suggest that adenocarcinoma of small bowel should be considered in the evaluation of acute abdominal pain in neurofibromatosis patients.

[MeSH-major] Adenocarcinoma / pathology. Ileal Neoplasms / pathology. Intestine, Small / pathology. Neoplasms, Multiple Primary / pathology. Neurofibromatosis 1 / pathology

[MeSH-minor] Abdomen, Acute / etiology. Aged. Follow-Up Studies. Humans. Intestinal Obstruction / etiology. Intestinal Obstruction / pathology. Male. Tomography, X-Ray Computed

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(PMID = 19473375.001).

[ISSN] 1365-2354

[Journal-full-title] European journal of cancer care

[ISO-abbreviation] Eur J Cancer Care (Engl)

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Successful treatment of recurrent small bowel adenocarcinoma by cytoreductive surgery and chemotherapy: a case report and review of the literature.

INTRODUCTION: Small bowel adenocarcinoma is a rare malignancy associated with a poor prognosis and there is little evidence of effective treatment.

Recurrent small bowel adenocarcinoma is an intractable disease for which there is little information available regarding its treatment by palliative therapy.

We present a case of recurrent small bowel adenocarcinoma successfully treated by cytoreductive surgery and palliative chemotherapy.

CASE PRESENTATION: We report the case of a 72-year-old Japanese female who developed a peritoneal metastasis from recurrent small bowel adenocarcinoma after curative resection and adjuvant chemotherapy with S-1 and polysaccharide K.

CONCLUSION: To the best of our knowledge, this is the first case report of the successful treatment of peritoneal metastasis from small bowel adenocarcinoma by cytoreductive surgery and combination chemotherapy (folinic acid/fluorouracil/oxaliplatin and folinic acid/fluorouracil/irinotecan with polysaccharide K).

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[Cites] J Surg Oncol. 2005 Aug 1;91(2):112-7; discussion 118-9 [16028284.001]

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(PMID = 20637117.001).

[ISSN] 1752-1947

[Journal-full-title] Journal of medical case reports

[ISO-abbreviation] J Med Case Rep

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2917439

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenocarcinoma of the small bowel: a 60-yr perspective derived from M. D. Anderson Cancer Center Tumor Registry.

OBJECTIVES: To analyze subsite distribution of small bowel adenocarcinoma (SBA) over a 60-yr interval and to determine the impact of age, gender, and ethnicity on SBA cross-referenced for selected variables including anatomic distribution.

METHODS: Data from 1944 to 2003 were extracted from the M. D.

[MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Intestinal Neoplasms / epidemiology. Intestinal Neoplasms / pathology. Intestine, Small

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(PMID = 16863573.001).

[ISSN] 0002-9270

[Journal-full-title] The American journal of gastroenterology

[ISO-abbreviation] Am. J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma.

BACKGROUND: Small bowel adenocarcinoma is a rare malignancy that presents both a diagnostic and therapeutic challenge.

We review our experience with small bowel peritoneal carcinomatosis following treatment with cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC).

METHODS: From a prospective database of CRS and PIC, seven patients were identified to have undergone treatment for small bowel peritoneal carcinomatosis with CRS and hyperthermic intraperitoneal chemotherapy (Mitomycin C) and early postoperative intraperitoneal chemotherapy (5FU).

Tumor histology of poorly differentiated adenocarcinoma with signet ring, lymphovascular invasion and perineural invasion appeared to be associated with a poor outcome.

CONCLUSION: Cytoreductive surgery and perioperative intraperitoneal chemotherapy is a treatment option for small bowel cancer peritoneal carcinomatosis with encouraging survival results.

[MeSH-major] Adenocarcinoma / therapy. Hyperthermia, Induced. Ileal Neoplasms / therapy. Jejunal Neoplasms / therapy

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(PMID = 19544356.001).

[ISSN] 1096-9098

[Journal-full-title] Journal of surgical oncology

[ISO-abbreviation] J Surg Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Noncolorectal malignancies in inflammatory bowel disease: more than meets the eye.

In patients with Crohn's disease, the risk of small bowel adenocarcinoma is 20-40 times higher than the low background risk of the general population.

In the subset of patients with longstanding small bowel lesions, the absolute risk of small bowel adenocarcinoma exceeds 1 per 100 patient-years after 25 years of follow-up and becomes equivalent to the risk of colorectal cancer.

Growing evidence suggests that the pathogenesis of small bowel adenocarcinoma arising in inflammatory lesions of Crohn's disease is similar to that of colorectal cancer complicating chronic colonic inflammation (inflammation-dysplasia-cancer sequence).

However, contrasting with the established endoscopic detection of colonic advanced neoplasias in patients with longstanding extensive colitis, there is no consensus at this time how to face the excess-risk of small bowel adenocarcinoma in patients at high risk.

There are no specific clinical or imaging alert signs and endoscopic surveillance of the totality of the inflamed small bowel mucosa would suppose to perform repeated enteroscopies, with the potential limiting factor of stenosis.

Data from referral centers and from the CESAME cohort suggest that intestinal lymphomas may arise in the chronically inflamed segments in patients with inflammatory bowel disease (IBD).

[MeSH-major] Colorectal Neoplasms / complications. Inflammatory Bowel Diseases / complications

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[Copyright] Copyright 2009 S. Karger AG, Basel.

(PMID = 19786768.001).

[ISSN] 1421-9875

[Journal-full-title] Digestive diseases (Basel, Switzerland)

[ISO-abbreviation] Dig Dis

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Switzerland

[Number-of-references] 46

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database.

BACKGROUND: The presence of distant metastases and the completeness of resection are important prognostic factors in patients with small bowel adenocarcinoma (SBA); however, the influence of lymph node metastasis on patient outcome has not been well characterized.

[MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small. Lymph Nodes / pathology

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[Copyright] Copyright © 2010 American Cancer Society.

(PMID = 20715162.001).

[ISSN] 0008-543X

[Journal-full-title] Cancer

[ISO-abbreviation] Cancer

[Language] eng

[Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Laparoscopic coincidental finding in a case of incomplete ileus: adenocarcinoma of the small intestine as first manifestation of Crohn's disease].

[Transliterated title] Laparoskopischer Zufallsbefund bei inkomplettem Ileus: Adenokarzinom des Dünndarms als Erstmanifestation eines Morbus Crohn.

The case-study reminds of adenocarcinoma of the small intestine as a rare complication of Crohn's disease.

Epidemiological studies concerning small bowel carcinoma showed consumption of sugar and carbohydrates as pathogenetic factors, other conditions like ileostoma, ileumconduit, Crohn's disease and coeliac disease have been identified to some extent.

An adenoma-carcinoma sequence as in large intestine carcinoma has been discussed.

Diagnosis of early stages of adenocarcinoma of the small intestine is very difficult and thus might be impossible to differentiate from exacerbation or progressive stenosis of preexisting Crohn's disease.

If non-invasive diagnostic measures (ultrasound, small bowel enema, CT-scan, intestinoscopy, radiography, NMR-Sellink, capsule-endoscopy) fail to clear the situation a diagnostic laparoscopy or even laparotomy should not be delayed.

[MeSH-major] Adenocarcinoma / surgery. Crohn Disease / surgery. Ileal Neoplasms / surgery. Ileus / surgery. Incidental Findings. Laparoscopy

[MeSH-minor] Aged. Appendectomy. Cell Transformation, Neoplastic / pathology. Cholecystectomy, Laparoscopic. Cholelithiasis / diagnosis. Cholelithiasis / surgery. Diagnosis, Differential. Female. Humans. Ileum / pathology. Ileum / surgery. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Neoplasm Invasiveness

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(PMID = 18098087.001).

[ISSN] 0044-409X

[Journal-full-title] Zentralblatt für Chirurgie

[ISO-abbreviation] Zentralbl Chir

[Language] ger

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Germany

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A rare case of primary small bowel adenocarcinoma with intussusception.

In contrast with the colon tract, the incidence of primary malignancies in the small bowel is very low.

We report the case of a 51-year-old man presenting with jejunal intussusception due to a primary adenocarcinoma.

The patient was referred to our division for bowel obstruction.

Histological examination of the specimen resulted in a diagnosis of a primary adenocarcinoma of the small bowel.

In adult intestinal intussusception, resection without reduction is considered the optimal management if an underlying primary malignancy cannot be excluded.

[MeSH-major] Adenocarcinoma / complications. Intussusception / etiology. Jejunal Diseases / etiology. Jejunal Neoplasms / complications

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(PMID = 20572601.001).

[ISSN] 0300-8916

[Journal-full-title] Tumori

[ISO-abbreviation] Tumori

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adjuvant chemotherapy for small intestine adenocarcinoma.

BACKGROUND: Although the small intestine represents 75% of the length and over 90% of the mucosal surface of the alimentary tract, it is the site of only about 2% of malignant gastrointestinal tumours.

Adenocarcinoma is the most common histological subtype, accounting for about 40% of all malignant small intestinal tumours.

The consequences are a significant delay in diagnosis and the finding of advanced, incurable disease at operation.

The rare nature of adenocarcinomas of the small intestine has led to a paucity of information about the benefits of adjuvant chemotherapy but there are reports of overall better survival for those patients that receive combination treatment.

OBJECTIVES: To determine the role of adjuvant chemotherapy in the management of adenocarcinoma of the small intestine compared to another adjuvant treatment, a placebo or no other adjuvant treatment.

SELECTION CRITERIA: Phase III randomised controlled trials comparing post-operative adjuvant chemotherapy for adenocarcinoma of the small intestine with other adjuvant therapies, placebo or no adjuvant treatment.

AUTHORS' CONCLUSIONS: There is a need for high quality randomised controlled trials to evaluate the effectiveness of adjuvant chemotherapy in the management of adenocarcinoma of the small intestine.

[MeSH-major] Adenocarcinoma / drug therapy. Intestinal Neoplasms / drug therapy. Intestine, Small

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(PMID = 17636789.001).

[ISSN] 1469-493X

[Journal-full-title] The Cochrane database of systematic reviews

[ISO-abbreviation] Cochrane Database Syst Rev

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Number-of-references] 36

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

BACKGROUND: There is very small occurrence of adenocarcinoma in the small bowel.

We present a case of primary duodenal adenocarcinoma and discuss the findings of the case diagnostic modalities, current knowledge on the molecular biology behind small bowel neoplasms and treatment options.

CASE: The patient had a history of iron deficiency anemia and occult bleeding with extensive workup consisting of upper endoscopy, colonoscopy, capsule endoscopy, upper gastrointestinal series with small bowel follow through and push enteroscopy.

Due to persistent abdominal pain and iron deficiency anemia the patient underwent push enteroscopy which revealed adenocarcinoma of the duodenum.

The patient underwent en-bloc duodenectomy which revealed T3N1M0 adenocarcinoma of the 4th portion of the duodenum.

CONCLUSIONS: Primary duodenal carcinoma, although rare should be considered in the differential diagnosis of occult gastrointestinal bleeding when evaluation of the lower and upper GI tract is unremarkable.

We discuss the current evaluation and management of this small bowel neoplasm.

[MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Duodenal Neoplasms / diagnosis

[MeSH-minor] Aged. Diagnosis, Differential. Duodenoscopy. Female. Humans. Laparotomy. Ligaments. Tomography, X-Ray Computed

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(PMID = 20849628.001).

[ISSN] 1471-230X

[Journal-full-title] BMC gastroenterology

[ISO-abbreviation] BMC Gastroenterol

[Language] eng

[Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor

[Other-IDs] NLM/ PMC2949773

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association?

After surgical excision and radiotherapy of dermatofibrosarcoma protuberans, the patient developed small bowel adenocarcinoma.

[MeSH-major] Adenocarcinoma / pathology. Dermatofibrosarcoma / pathology. Intestinal Neoplasms / pathology. Neoplasms, Second Primary / pathology. Skin Neoplasms / pathology

[MeSH-minor] Adult. Humans. Intestine, Small / pathology. Intestine, Small / radiography. Male. Tumor Suppressor Protein p53 / genetics

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(PMID = 18175227.001).

[ISSN] 1537-3649

[Journal-full-title] International journal of gastrointestinal cancer

[ISO-abbreviation] Int J Gastrointest Cancer

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases.

Small intestinal adenocarcinoma is a rare malignant neoplasm, and its clinicopathologic characteristics have not been well elucidated.

A total of 197 small intestinal adenocarcinoma cases were collected from 22 institutions in South Korea and were evaluated for clinicopathologic factors that affect the prognosis of small intestinal adenocarcinoma patients using univariate and multivariate analyses.

The median survival time for all small intestinal adenocarcinoma patients was 39.7 months.

Compared with small intestinal adenocarcinomas without accompanying sporadic adenomas, small intestinal adenocarcinomas with accompanying adenomas were more well differentiated (P < .0001), with a more polypoid growth pattern (P < .0001), a lower pT classification (P < .0001), less perineural invasion (P = .01), and less lymphatic invasion (P = .03).

Small intestinal adenocarcinoma patients with associated sporadic adenomas (77%) had a significantly better 5-year survival rate than those without sporadic adenomas (38%, P = .02).

By univariate analysis, small intestinal adenocarcinoma patients had significantly different survival based on pT classification (P = .003), lymph node metastasis (P < .0001), distal location (jejunal and ileal carcinomas) (P = .003), retroperitoneal tumor seeding (P < .0001), vascular invasion (P = .007), lymphatic invasion (P = .001), peritumoral dysplasia (P = .004), and radiation therapy (P = .006).

In conclusion, (1) small intestinal adenocarcinomas are diagnosed at an advanced disease stage; therefore, the development of strategies for detection at an earlier stage is needed. (2) Small intestinal adenocarcinoma patients with an adenomatous component had a better survival than those without an adenomatous component. (3) Lymph node metastasis and distal location (jejunum and ileum) of tumor are the most important independent prognostic factors.

[MeSH-major] Adenocarcinoma / pathology. Duodenal Neoplasms / pathology. Ileal Neoplasms / pathology. Jejunal Neoplasms / pathology

[MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intestine, Small / pathology. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Prognosis

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[Copyright] 2010 Elsevier Inc. All rights reserved.

(PMID = 20334897.001).

[ISSN] 1532-8392

[Journal-full-title] Human pathology

[ISO-abbreviation] Hum. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Complete response of an initially non-surgical adenocarcinoma of the duodenum to chemotherapy with the FOLFOX 4 regimen.

INTRODUCTION: The incidence of adenocarcinoma of the small bowel is very low in comparison with that of colorectal cancer.

No standard chemotherapy is defined for non-surgical adenocarcinoma of the small bowel.

CASE REPORT: We report here the case of a young patient with an initially non-surgical adenocarcinoma of the duodenum treated in a palliative setting with the FOLFOX 4 chemotherapy regimen.

CONCLUSION: The FOLFOX 4 regimen seems to be efficacious for some small-bowel adenocarcinomas and can be expected to lead to downstaging.

[MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy

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(PMID = 19585173.001).

[ISSN] 1873-4626

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.

Patients with long-standing ulcerative colitis and Crohn's disease have an increased risk of developing colorectal cancer and patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.

Colorectal cancer appearing on the ground of inflammatory bowel disease is the result of a process which is believed to begin from no dysplasia progressing to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma, although colorectal cancer can arise without proceeding through each of these steps.

[MeSH-major] Cell Transformation, Neoplastic. Colorectal Neoplasms / epidemiology. Inflammatory Bowel Diseases / epidemiology

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(PMID = 19596953.001).

[ISSN] 1791-7530

[Journal-full-title] Anticancer research

[ISO-abbreviation] Anticancer Res.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Greece

[Number-of-references] 94

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Intestinal cancer in patients with Crohn's disease.

BACKGROUND: Surveillance of intestinal cancer in Crohn's disease (CD) has often been advocated.

To date, no clear evidence exists whether CD patients are at special risk for intestinal cancer.

An increased incidence of small bowel adenocarcinoma is suggested.

We report our experience with 10 cases of CD complicated by intestinal adenocarcinoma.

Data of patients that developed carcinoma within Crohn's lesions of either small or large bowel were analyzed.

Mean age at the time of diagnosis of CD was 43 years.

Mean duration of CD until diagnosis of cancer was 14 years.

Delayed diagnosis resulted in a poor prognosis.

[MeSH-major] Crohn Disease / complications. Intestinal Neoplasms / etiology

[MeSH-minor] Adult. Colorectal Neoplasms. Databases, Factual. Female. Humans. Ileitis. Incidence. Intestinal Fistula. Male. Middle Aged. Survival Rate

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(PMID = 16847674.001).

[ISSN] 0179-1958

[Journal-full-title] International journal of colorectal disease

[ISO-abbreviation] Int J Colorectal Dis

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Small bowel adenocarcinoma with high levels of microsatellite instability in Crohn's disease.

We report the case of a 26-year-old man, diagnosed 4 years earlier with Crohn's disease, who developed an associated small bowel adenocarcinoma.

[MeSH-major] Adenocarcinoma / pathology. Crohn Disease / pathology. Genomic Instability. Ileal Neoplasms / pathology. Microsatellite Repeats

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(PMID = 16647963.001).

[ISSN] 0046-8177

[Journal-full-title] Human pathology

[ISO-abbreviation] Hum. Pathol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Cancer in inflammatory bowel disease.

Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC).

Colon cancer risk in inflammatory bowel disease increases with longer duration of colitis, greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of the bowel.

Patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.

Other extra intestinal cancers, such as hepatobiliary and hematopoietic cancer, have shown variable incidence rates.

[MeSH-major] Colorectal Neoplasms / physiopathology. Inflammatory Bowel Diseases / physiopathology. Neoplasms / physiopathology

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(PMID = 18200660.001).

[ISSN] 1007-9327

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] China

[Number-of-references] 118

[Other-IDs] NLM/ PMC2679126