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6. Parfenov AI, Krums LM, Sivash ES, Tsaregorodtseva TM, Poleva NI, Ruchkina IN, Sabel'nikova EA, Chikunova BZ: [Algorithm for diagnosis of small intestinal diseases]. Ter Arkh; 2008;80(4):46-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Algorithm for diagnosis of small intestinal diseases].
  • AIM: To review diagnostic approaches in chronic diseases of the small intestine.
  • MATERIAL AND METHODS: A total of 1096 patients with chronic diseases of the small intestine were admitted to the clinic of the Central Research Institute of Gastroenterological Diseases in 1987-2006.
  • RESULTS: Most of the patients (90.5%) had celiac disease, hypolactasia and other types of disaccharidase deficiency, yersiniosis ileitis, Krohn's disease, postresection syndrome of a short small intestine, mesenterial ischemia and endocrine enteropathy.
  • Rare diseases (general variable hypogammaglobulinemia, lymphoma, Wipple's disease and diverticulosis of the small intestine) were diagnosed in 5.8% cases.
  • Primary amyloidosis of the small intestine, eosinophilic gastroenteritis, arteriomesenterial obstruction, primary intestinal pseudoobstruction, hypogammaglobulinemic spru, primary intestinal lymphangiectasia, tuberculosis, total polyposis, Peutz-Eggers and Cronkhite-Canada syndromes, collagenic sprue, erosive-ulcerative jejunoileitis, adenocarcinoma and heavy alpha-chain disease were detected in 3.7% examinees.
  • CONCLUSION: Clinical diagnosis of small intestinal diseases is based on the syndromes of chronic diarrhea, defective absorption, enteral protein loss, small intestinal obstruction and intestinal hemorrhage.
  • Differential diagnosis of the nosological entities employs x-ray, endoscopic, histological, immunological and other methods.
  • Most of the small intestinal diseases including rare can be diagnosed in any gastroentorological department.
  • [MeSH-major] Algorithms. Endoscopy, Gastrointestinal / methods. Immunologic Tests / methods. Intestinal Diseases / diagnosis. Intestine, Small. Radiography, Abdominal / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18491580.001).
  • [ISSN] 0040-3660
  • [Journal-full-title] Terapevticheskiĭ arkhiv
  • [ISO-abbreviation] Ter. Arkh.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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7. Husain S, Thompson D, Thomas L, Donaldson B, Sabbagh R: Adnexal mass: an unusual presentation of small-bowel adenocarcinoma. J Natl Med Assoc; 2006 May;98(5):799-802
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adnexal mass: an unusual presentation of small-bowel adenocarcinoma.
  • Malignancy of the small bowel presents unique diagnostic and therapeutic challenges resulting in a delayed diagnosis in many cases.
  • Small-bowel tumors respond poorly to most forms of treatment.
  • Metastatic lesions to the ovaries comprise a small percentage of all ovarian malignant neoplasms.
  • Ovarian metastases from primary small-bowel tumors are often difficult to differentiate from primary ovarian tumors.
  • Only few reports have described ovarian metastases from small-bowel sources.
  • A high index of suspicion can lead to an earlier diagnosis and can have an impact on the therapeutic options as well as the survival of the patients.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adnexal Diseases / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small / pathology
  • [MeSH-minor] Abdominal Pain. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 16749659.001).
  • [ISSN] 1943-4693
  • [Journal-full-title] Journal of the National Medical Association
  • [ISO-abbreviation] J Natl Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Caruso S, Marrelli D, Pedrazzani C, Neri A, Mazzei MA, Onorati M, Corso G, Cerullo G, Roviello F: A rare case of primary small bowel adenocarcinoma with intussusception. Tumori; 2010 Mar-Apr;96(2):355-7
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  • [Title] A rare case of primary small bowel adenocarcinoma with intussusception.
  • In contrast with the colon tract, the incidence of primary malignancies in the small bowel is very low.
  • We report the case of a 51-year-old man presenting with jejunal intussusception due to a primary adenocarcinoma.
  • The patient was referred to our division for bowel obstruction.
  • Histological examination of the specimen resulted in a diagnosis of a primary adenocarcinoma of the small bowel.
  • In adult intestinal intussusception, resection without reduction is considered the optimal management if an underlying primary malignancy cannot be excluded.
  • [MeSH-major] Adenocarcinoma / complications. Intussusception / etiology. Jejunal Diseases / etiology. Jejunal Neoplasms / complications

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  • (PMID = 20572601.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Dasari BV, Gardiner KR: Management of adenocarcinoma of the small intestine. Gastrointest Cancer Res; 2009 May;3(3):121-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of adenocarcinoma of the small intestine.

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  • (PMID = 19626156.001).
  • [ISSN] 1934-7820
  • [Journal-full-title] Gastrointestinal cancer research : GCR
  • [ISO-abbreviation] Gastrointest Cancer Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2713137
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10. Tankova L, Berberova M, Damianov N, Tsankov Ts, Kovatchki D: Preoperative diagnosis of jejunal adenocarcinoma--a case report. J BUON; 2008 Jan-Mar;13(1):123-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative diagnosis of jejunal adenocarcinoma--a case report.
  • We report herein the case of a preoperatively diagnosed small bowel adenocarcinoma.
  • An US-guided fine (20 gauge) needle aspiration (FNA) cytology of the mass was performed and showed moderately differentiated adenocarcinoma of intestinal origin.
  • On surgical exploration a jejunal tumor of high consistency was found, located 15 cm distantly from the Treitz ligament, infiltrating up to 2/3 of the bowel circumference and partly obstructing its lumen.
  • The histological evaluation of the resected material showed highly to moderately differentiated adenocarcinoma with 5 regional lymph node metastases.
  • The combination of US with Doppler and FNA established preoperatively the malignant small bowel disease.
  • [MeSH-major] Adenocarcinoma / diagnosis. Jejunal Neoplasms / diagnosis

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  • (PMID = 18404799.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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11. Shukla S, Singh SK, Pujani M: Multicentric malignant gastrointestinal stromal tumor. Saudi J Gastroenterol; 2009 Jan;15(1):45-8
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  • Ultrasound examination showed a small bowel mass along with multiple peritoneal deposits and a mass within the liver.
  • A differential diagnosis of adenocarcinoma/lymphoma with metastases was entertained.
  • Perioperative findings showed two large growths arising from the jejunum and the distal ileum, along with multiple smaller nodules on the serosal surface and adjoining mesentery of the involved bowel segments.
  • Segmental resection of the involved portions of the intestine was performed.
  • Histopathological features were consistent with those of multicentric malignant GIST-not otherwise specified (GIST-NOS).

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  • (PMID = 19568556.001).
  • [ISSN] 1319-3767
  • [Journal-full-title] Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
  • [ISO-abbreviation] Saudi J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC2702961
  • [Keywords] NOTNLM ; GIST / malignant / multicentric
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12. Daniels JA, Lederman HM, Maitra A, Montgomery EA: Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review. Am J Surg Pathol; 2007 Dec;31(12):1800-12
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  • METHODS: We reviewed clinical documentation and samples from 132 separate GI biopsy or resection sites on 20 CVID patients obtained over a 26-year period, including biopsies from the colon (34), esophagus (19), small intestine (38), and stomach (35), a partial gastrectomy, small bowel resection, colectomy, 2 cholecystectomies, and 1 appendectomy.
  • Age at diagnosis ranged from 6 months to 62 years (median, 35.5 y), and age at biopsy ranged from 10 months to 67 years (median, 38 y).
  • Gastric adenocarcinoma was identified in one patient.
  • There was a paucity of small bowel plasma cells in the majority of patients (68%).
  • The small bowel showed prominent lymphoid aggregates in about half (47%).
  • Its features can mimic lymphocytic colitis, collagenous enterocolitis, celiac disease, lymphocytic gastritis, granulomatous disease, acute graft-versus-host disease, and inflammatory bowel disease.
  • In fact, in our series, we found patients with a prior diagnosis of celiac disease (25%) and inflammatory bowel disease (35%), including Crohn disease (15%).
  • The diagnosis of CVID may be suspected on the basis of the lack of plasma cells in a GI biopsy, but because this feature is only present in about two-thirds of patients, the diagnosis cannot always be suggested in isolation of other clinical and laboratory findings.
  • [MeSH-minor] Adolescent. Adult. Aged. Celiac Disease / pathology. Child. Child, Preschool. Colitis, Collagenous / pathology. Colitis, Lymphocytic / pathology. Diagnosis, Differential. Female. Granulomatous Disease, Chronic / pathology. Humans. Infant. Inflammatory Bowel Diseases / pathology. Male. Middle Aged

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  • (PMID = 18043034.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Overman MJ, Varadhachary GR, Kopetz S, Adinin R, Lin E, Morris JS, Eng C, Abbruzzese JL, Wolff RA: Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater. J Clin Oncol; 2009 Jun 1;27(16):2598-603
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  • [Title] Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
  • PURPOSE: Adenocarcinomas of the small bowel and ampulla of Vater represent rare cancers that have limited data regarding first-line therapy.
  • We conducted a phase II trial to evaluate the benefit of capecitabine in combination with oxaliplatin (CAPOX) in patients with advanced adenocarcinoma of small bowel or ampullary origin.
  • CAPOX should be considered a new standard regimen for advanced small bowel and ampullary adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / drug therapy. Ampulla of Vater / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Common Bile Duct Neoplasms / drug therapy. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology

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  • (PMID = 19164203.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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4. Bilici A, Karadag B, Doventas A, Seker M: Gastric pneumatosis intestinalis associated with malignancy: an unusual case report. World J Gastroenterol; 2009 Feb 14;15(6):758-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The most common localization is the small intestine.
  • We report on a 94-year-old man with gastric PI associated with inoperable adenocarcinoma localized in the duodenum.
  • We suggest that in patients presenting with PI, malignancy should be considered in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Duodenal Neoplasms / diagnosis. Pneumatosis Cystoides Intestinalis / diagnosis. Pneumatosis Cystoides Intestinalis / radiography
  • [MeSH-minor] Aged, 80 and over. Blood Proteins / analysis. Blood Proteins / isolation & purification. Diagnosis, Differential. Fatal Outcome. Humans. Male. Stomach Diseases / diagnosis. Stomach Diseases / etiology. Stomach Diseases / radiography. Tomography, X-Ray Computed. Urine / cytology

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  • (PMID = 19222105.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Blood Proteins
  • [Other-IDs] NLM/ PMC2653449
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15. Bulfoni A: [Primary adenocarcinoma of jejunum with obscure gastrointestinal bleeding]. Clin Ter; 2006 Sep-Oct;157(5):431-4
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  • [Title] [Primary adenocarcinoma of jejunum with obscure gastrointestinal bleeding].
  • [Transliterated title] Adenocarcinoma primitivo del digiuno ad esteriorizzazione con enterorragia.
  • A case of primary small bowel adenocarcinoma is reported because of the rarity of this malignancy.
  • [MeSH-major] Adenocarcinoma. Gastrointestinal Hemorrhage / etiology. Jejunal Neoplasms
  • [MeSH-minor] Capsule Endoscopy. Diagnosis, Differential. Female. Humans. Jejunum / pathology. Middle Aged. Occult Blood. Prognosis

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  • (PMID = 17147051.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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21. Posey JA 3rd, Saif MW, Carlisle R, Goetz A, Rizzo J, Stevenson S, Rudoltz MS, Kwiatek J, Simmons P, Rowinsky EK, Takimoto CH, Tolcher AW: Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas. Clin Cancer Res; 2005 Nov 1;11(21):7866-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Unconfirmed partial responses were observed in two patients, one with metastatic small bowel adenocarcinoma and the other with metastatic esophageal cancer.

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  • (PMID = 16278410.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR00032
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 30IQX730WE / Polyethylene Glycols; 581079-18-7 / pegamotecan; XT3Z54Z28A / Camptothecin
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22. Ausloos F, Scagnol I, Belaiche J: [Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report]. Rev Med Liege; 2009 Jul-Aug;64(7-8):394-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report].
  • [Transliterated title] Adénocarcinome de l'intestin grêle compliquant une maladie coeliaque de l'adulte: à propos d'un cas.
  • This small bowel adenocarcinoma is rare and concerns less than 5% of the digestive neoplasias.
  • We are reporting the case of a 67-years-old woman whose coeliac disease has been complicated 5 years thereafter by a jejunal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Celiac Disease / complications. Incidental Findings. Jejunal Neoplasms / complications. Jejunal Neoplasms / diagnosis

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  • (PMID = 19777919.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
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23. Kudo K, Funayama Y, Fukushima K, Shibata C, Takahashi K, Ogawa H, Ueno T, Haneda S, Watanabe K, Koyama A, Hayashi K, Hiwatashi N, Kinouchi Y, Shimosegawa T, Sasaki I: [Carcinoma arising from ileorectal fistula in a patient with Crohn's disease]. Nihon Shokakibyo Gakkai Zasshi; 2007 Oct;104(10):1492-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 72-year-old man was given a diagnosis of Crohn's disease in 1976 at age 44, and partial resection of is ileum was performed.
  • Ileocecal resection, partial resection of is small intestine and loop sigmoid colostomy were performed.
  • Endoscopic examination showed a fistula orifice in the rectum and biopsy of the fistula revealed mucinous adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Crohn Disease / complications. Ileal Diseases / complications. Intestinal Fistula / complications. Rectal Fistula / complications. Rectal Neoplasms / etiology

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  • (PMID = 17917397.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 12
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24. Yamaga Y, Ohana M, Nakamura T, Kikuchi S, Matsumura K, Takita M, Iwamoto S, Morisawa T, Miyajima S, Kida H, Okano A, Okinaga S, Kusumi F, Takakuwa H, Honjou G: [A case of jejunal adenocarcinoma with serum DUPAN-2 elevation]. Nihon Shokakibyo Gakkai Zasshi; 2010 Nov;107(11):1806-13
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  • [Title] [A case of jejunal adenocarcinoma with serum DUPAN-2 elevation].
  • Ileus with ulcerated jejunal tumor was diagnosed and biopsy revealed adenocarcinoma.
  • Surgical resection was performed: both tumors were adenocarcinoma, but the ovarian tumor was considered to be metastatic clinically and histologically.
  • This case shows a possible relation between small bowel adenocarcinoma and DUPAN-2.
  • [MeSH-major] Adenocarcinoma / diagnosis. Antigens, Neoplasm / blood. Jejunal Neoplasms / diagnosis

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  • (PMID = 21071898.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DU-PAN-2 antigen, human
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25. Piton G, Cosnes J, Monnet E, Beaugerie L, Seksik P, Savoye G, Cadiot G, Flourie B, Capelle P, Marteau P, Lemann M, Colombel JF, Khouri E, Bonaz B, Carbonnel F: Risk factors associated with small bowel adenocarcinoma in Crohn's disease: a case-control study. Am J Gastroenterol; 2008 Jul;103(7):1730-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors associated with small bowel adenocarcinoma in Crohn's disease: a case-control study.
  • BACKGROUND AND AIMS: It is well established that Crohn's disease (CD) is associated with an increased risk of small bowel adenocarcinoma (SBA).
  • METHODS: In 11 French centers affiliated with the GETAID (Groupe d'Etude Thérapeutique des Affections Inflammatoires du Tube Digestif), we identified 29 patients with CD and SBA.
  • RESULTS: In univariate analysis, the cases had had significantly less small bowel resection and received prolonged treatment with salicylates (more than 2 yr), less often than the controls (odds ratio, OR [95% confidence interval, CI] 0.07 [0.01-0.32] and 0.29 [0.10-0.82], respectively).
  • CONCLUSION: This study suggests that small bowel resection and prolonged salicylates use may protect against SBA in CD patients.
  • [MeSH-major] Adenocarcinoma / etiology. Crohn Disease / complications. Intestinal Neoplasms / etiology. Intestine, Small

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  • [CommentIn] Inflamm Bowel Dis. 2009 Sep;15(9):1434-5 [19202570.001]
  • (PMID = 18564124.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Salicylates
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26. Chang HK, Yu E, Kim J, Bae YK, Jang KT, Jung ES, Yoon GS, Kim JM, Oh YH, Bae HI, Kim GI, Jung SJ, Gu MJ, Kim JY, Jang KY, Jun SY, Eom DW, Kwon KW, Kang GH, Park JB, Hong S, Lee JS, Park JY, Hong SM, Korean Small Intestinal Cancer Study Group: Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases. Hum Pathol; 2010 Aug;41(8):1087-96
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  • [Title] Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases.
  • Small intestinal adenocarcinoma is a rare malignant neoplasm, and its clinicopathologic characteristics have not been well elucidated.
  • A total of 197 small intestinal adenocarcinoma cases were collected from 22 institutions in South Korea and were evaluated for clinicopathologic factors that affect the prognosis of small intestinal adenocarcinoma patients using univariate and multivariate analyses.
  • The median survival time for all small intestinal adenocarcinoma patients was 39.7 months.
  • Compared with small intestinal adenocarcinomas without accompanying sporadic adenomas, small intestinal adenocarcinomas with accompanying adenomas were more well differentiated (P < .0001), with a more polypoid growth pattern (P < .0001), a lower pT classification (P < .0001), less perineural invasion (P = .01), and less lymphatic invasion (P = .03).
  • Small intestinal adenocarcinoma patients with associated sporadic adenomas (77%) had a significantly better 5-year survival rate than those without sporadic adenomas (38%, P = .02).
  • By univariate analysis, small intestinal adenocarcinoma patients had significantly different survival based on pT classification (P = .003), lymph node metastasis (P < .0001), distal location (jejunal and ileal carcinomas) (P = .003), retroperitoneal tumor seeding (P < .0001), vascular invasion (P = .007), lymphatic invasion (P = .001), peritumoral dysplasia (P = .004), and radiation therapy (P = .006).
  • In conclusion, (1) small intestinal adenocarcinomas are diagnosed at an advanced disease stage; therefore, the development of strategies for detection at an earlier stage is needed. (2) Small intestinal adenocarcinoma patients with an adenomatous component had a better survival than those without an adenomatous component. (3) Lymph node metastasis and distal location (jejunum and ileum) of tumor are the most important independent prognostic factors.
  • [MeSH-major] Adenocarcinoma / pathology. Duodenal Neoplasms / pathology. Ileal Neoplasms / pathology. Jejunal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intestine, Small / pathology. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Prognosis

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20334897.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Catassi C, Bearzi I, Holmes GK: Association of celiac disease and intestinal lymphomas and other cancers. Gastroenterology; 2005 Apr;128(4 Suppl 1):S79-86
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  • [Title] Association of celiac disease and intestinal lymphomas and other cancers.
  • Celiac disease (CD) is associated with intestinal lymphoma and other forms of cancer, especially adenocarcinoma of the small intestine, of the pharynx, and of the esophagus.
  • Enteropathy-associated T-cell lymphoma (EATL) is a rare form of high-grade, T-cell non-Hodgkin lymphoma (NHL) of the upper small intestine that is specifically associated with CD.
  • EATL derives from a clonal proliferation of intraepithelial lymphocytes and is often disseminated at diagnosis.
  • [MeSH-major] Adenocarcinoma / etiology. Celiac Disease / complications. Gastrointestinal Neoplasms / etiology. Intestinal Neoplasms / etiology. Lymphoma, T-Cell / etiology

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  • (PMID = 15825131.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 8002-80-0 / Glutens
  • [Number-of-references] 40
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28. Singhal N, Singhal D: Adjuvant chemotherapy for small intestine adenocarcinoma. Cochrane Database Syst Rev; 2007;(3):CD005202
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  • [Title] Adjuvant chemotherapy for small intestine adenocarcinoma.
  • BACKGROUND: Although the small intestine represents 75% of the length and over 90% of the mucosal surface of the alimentary tract, it is the site of only about 2% of malignant gastrointestinal tumours.
  • Adenocarcinoma is the most common histological subtype, accounting for about 40% of all malignant small intestinal tumours.
  • The consequences are a significant delay in diagnosis and the finding of advanced, incurable disease at operation.
  • The rare nature of adenocarcinomas of the small intestine has led to a paucity of information about the benefits of adjuvant chemotherapy but there are reports of overall better survival for those patients that receive combination treatment.
  • OBJECTIVES: To determine the role of adjuvant chemotherapy in the management of adenocarcinoma of the small intestine compared to another adjuvant treatment, a placebo or no other adjuvant treatment.
  • SELECTION CRITERIA: Phase III randomised controlled trials comparing post-operative adjuvant chemotherapy for adenocarcinoma of the small intestine with other adjuvant therapies, placebo or no adjuvant treatment.
  • AUTHORS' CONCLUSIONS: There is a need for high quality randomised controlled trials to evaluate the effectiveness of adjuvant chemotherapy in the management of adenocarcinoma of the small intestine.
  • [MeSH-major] Adenocarcinoma / drug therapy. Intestinal Neoplasms / drug therapy. Intestine, Small

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  • (PMID = 17636789.001).
  • [ISSN] 1469-493X
  • [Journal-full-title] The Cochrane database of systematic reviews
  • [ISO-abbreviation] Cochrane Database Syst Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 36
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29. Speranza G, Doroshow JH, Kummar S: Adenocarcinoma of the small bowel: changes in the landscape? Curr Opin Oncol; 2010 Jul;22(4):387-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the small bowel: changes in the landscape?
  • PURPOSE OF REVIEW: Small bowel adenocarcinoma (SBA) is a rare cancer with a poor prognosis and little information to guide its management.
  • RECENT FINDINGS: Recent advances in less invasive imaging tools may permit earlier and increased diagnosis of SBA.
  • SUMMARY: The rarity of the disease and difficulty in diagnosis contribute to the lack of prospective trials evaluating therapies for SBA.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestine, Small / drug effects. Intestine, Small / surgery

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  • (PMID = 20485170.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 2S9ZZM9Q9V / Bevacizumab; B76N6SBZ8R / gemcitabine
  • [Number-of-references] 43
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30. Fishman PN, Pond GR, Moore MJ, Oza A, Burkes RL, Siu LL, Feld R, Gallinger S, Greig P, Knox JJ: Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases. Am J Clin Oncol; 2006 Jun;29(3):225-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases.
  • BACKGROUND: Small bowel adenocarcinoma is a rare cancer that has generally been considered resistant to chemotherapy, although little has been published on the role of chemotherapy.
  • A retrospective analysis was conducted of patients with advanced small bowel adenocarcinoma to explore chemotherapy use, and gain knowledge for ongoing management and future clinical trials.
  • PATIENTS AND METHODS: All patients with advanced adenocarcinoma of the small bowel treated at Princess Margaret Hospital (PMH) between 1986 and 2004 were identified through the cancer registry.
  • CONCLUSION: Chemotherapy appears to have activity in adenocarcinoma of the small bowel.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestinal Neoplasms / pathology

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  • (PMID = 16755174.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. López-Cano M, Mañas MJ, Hermosilla E, Espín E: Multivisceral resection for colon cancer: analysis of prognostic factors. Dig Surg; 2010 Aug;27(3):238-45
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  • Fifty-two patients had sigmoid tumors and 48 involvement of the small intestine.
  • The diagnosis was conventional adenocarcinoma in 94 patients.
  • [MeSH-minor] Abdomen, Acute. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Follow-Up Studies. Gastrointestinal Hemorrhage / complications. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Recurrence

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  • (PMID = 20571272.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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32. Kalogerinis PT, Poulos JE, Morfesis A, Daniels A, Georgakila S, Daignualt T, Georgakilas AG: Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective. BMC Gastroenterol; 2010;10:109
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  • BACKGROUND: There is very small occurrence of adenocarcinoma in the small bowel.
  • We present a case of primary duodenal adenocarcinoma and discuss the findings of the case diagnostic modalities, current knowledge on the molecular biology behind small bowel neoplasms and treatment options.
  • CASE: The patient had a history of iron deficiency anemia and occult bleeding with extensive workup consisting of upper endoscopy, colonoscopy, capsule endoscopy, upper gastrointestinal series with small bowel follow through and push enteroscopy.
  • Due to persistent abdominal pain and iron deficiency anemia the patient underwent push enteroscopy which revealed adenocarcinoma of the duodenum.
  • The patient underwent en-bloc duodenectomy which revealed T3N1M0 adenocarcinoma of the 4th portion of the duodenum.
  • CONCLUSIONS: Primary duodenal carcinoma, although rare should be considered in the differential diagnosis of occult gastrointestinal bleeding when evaluation of the lower and upper GI tract is unremarkable.
  • We discuss the current evaluation and management of this small bowel neoplasm.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Duodenal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Duodenoscopy. Female. Humans. Laparotomy. Ligaments. Tomography, X-Ray Computed

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  • (PMID = 20849628.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2949773
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33. Overman MJ, Hu CY, Wolff RA, Chang GJ: Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database. Cancer; 2010 Dec 1;116(23):5374-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database.
  • BACKGROUND: The presence of distant metastases and the completeness of resection are important prognostic factors in patients with small bowel adenocarcinoma (SBA); however, the influence of lymph node metastasis on patient outcome has not been well characterized.
  • [MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small. Lymph Nodes / pathology

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  • [Copyright] Copyright © 2010 American Cancer Society.
  • (PMID = 20715162.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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34. Aurello P, Dente M, D'Angelo F, Nigri G, Cescon M, Ramacciato G: Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient. Am Surg; 2009 Feb;75(2):189-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient.
  • [MeSH-major] Adenocarcinoma / pathology. Crohn Disease / etiology. Ileal Neoplasms / pathology. Intestinal Obstruction / etiology


35. Guimarães GC, Terabe F, Rossi BM, Aguiar Júnior S, Ferreira Fde O, Nakagawa WT, Lopes A: The double-barreled wet ileostomy: an alternative method for simultaneous urinary and intestinal diversion without intestinal anastomosis after total colectomy and pelvic exenteration. Int J Colorectal Dis; 2005 Mar;20(2):190-3
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  • [Title] The double-barreled wet ileostomy: an alternative method for simultaneous urinary and intestinal diversion without intestinal anastomosis after total colectomy and pelvic exenteration.
  • [MeSH-major] Adenocarcinoma / therapy. Colectomy / methods. Colonic Neoplasms / therapy. Ileostomy. Intestine, Small / surgery. Urinary Diversion / methods
  • [MeSH-minor] Anastomosis, Roux-en-Y. Colonoscopy. Follow-Up Studies. Humans. Male. Middle Aged. Prostatectomy. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / secondary. Prostatic Neoplasms / surgery. Radiotherapy, Adjuvant. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 15688101.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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36. Gümüştaş OG, Gümüştaş A, Yalçin R, Savci G, Soylu RA: Unusual causes of small bowel obstruction and contemporary diagnostic algorithm. J Med Imaging Radiat Oncol; 2008 Jun;52(3):208-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual causes of small bowel obstruction and contemporary diagnostic algorithm.
  • Intestinal obstruction is a common clinical abnormality.
  • In 60-80% of cases, the small bowel is affected.
  • Although postoperative adhesions are responsible in 60% of cases, the other frequently observed causes are hernia, strangulation and tumours, such as carcinoid, lymphoma or adenocarcinoma.
  • In this pictorial essay, we presented the radiological findings of uncommon causes of small bowel obstruction as well as the suggested diagnostic algorithm.
  • [MeSH-major] Decision Support Systems, Clinical. Hernia / complications. Hernia / diagnosis. Intestinal Neoplasms / complications. Intestinal Neoplasms / diagnosis. Intestinal Obstruction / diagnosis. Intestinal Obstruction / etiology. Intestine, Small
  • [MeSH-minor] Diagnosis, Differential. Humans. Practice Guidelines as Topic. Practice Patterns, Physicians' / trends. Rare Diseases / complications. Rare Diseases / diagnosis

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  • (PMID = 18477114.001).
  • [ISSN] 1754-9485
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 30
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37. Yamada K, Ikehara Y, Nakanishi H, Kozawa E, Tatematsu M, Sugiura H: Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma. J Orthop Sci; 2007 Nov;12(6):606-10
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  • [Title] Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma.
  • [MeSH-major] Acetabulum. Adenocarcinoma / secondary. Bone Neoplasms / secondary. Jejunal Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed

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  • (PMID = 18040646.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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38. Stratopoulos C, Papakonstantinou A, Anagnostopoulos G, Terzis I, Tzimas G, Gourgiotis S, Vamvouka C, Hadjiyannakis E: Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study. Eur J Cancer Care (Engl); 2009 Sep;18(5):466-9
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  • [Title] Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study.
  • However, the coexistence of neurofibromatosis with small-bowel adenocarcinoma is exceedingly rare.
  • We present an uncommon case of neurofibromatosis type 1, involving the small bowel in a 73-year-old man, who was admitted to our department with signs of acute abdomen.
  • These nodules obstructed ileal lumen, while the intestine wall was perforated in one point.
  • Histology revealed neurofibromatosis type 1 with malignant transformation to small-bowel adenocarcinoma.
  • We suggest that adenocarcinoma of small bowel should be considered in the evaluation of acute abdominal pain in neurofibromatosis patients.
  • [MeSH-major] Adenocarcinoma / pathology. Ileal Neoplasms / pathology. Intestine, Small / pathology. Neoplasms, Multiple Primary / pathology. Neurofibromatosis 1 / pathology
  • [MeSH-minor] Abdomen, Acute / etiology. Aged. Follow-Up Studies. Humans. Intestinal Obstruction / etiology. Intestinal Obstruction / pathology. Male. Tomography, X-Ray Computed

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  • (PMID = 19473375.001).
  • [ISSN] 1365-2354
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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39. Saurin JC, Pilleul F, Soussan EB, Manière T, D'Halluin PN, Gaudric M, Cellier C, Heresbach D, Gaudin JL, Capsule Commission of the French Society of Digestive Endoscopy (SFED): Small-bowel capsule endoscopy diagnoses early and advanced neoplasms in asymptomatic patients with Lynch syndrome. Endoscopy; 2010 Dec;42(12):1057-62
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  • [Title] Small-bowel capsule endoscopy diagnoses early and advanced neoplasms in asymptomatic patients with Lynch syndrome.
  • BACKGROUND AND STUDY AIMS: Patients with Lynch syndrome are at increased risk of developing small-bowel adenocarcinoma, which usually has a bad prognosis and needs to be diagnosed early.
  • RESULTS: Histologically confirmed small-bowel neoplasms were diagnosed in three patients (8.6 %): one adenocarcinoma (T3N0M0) and two adenomas with low-grade dysplasia.
  • CT enteroclysis raised suspicion of one neoplasm (adenocarcinoma) but missed the two others.
  • The clinical usefulness of systematic small-bowel screening in these patients should be confirmed through large prospective studies.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Capsule Endoscopy. Colorectal Neoplasms, Hereditary Nonpolyposis / complications. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20821360.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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40. Fraquelli M, Sciola V, Villa C, Conte D: The role of ultrasonography in patients with celiac disease. World J Gastroenterol; 2006 Feb 21;12(7):1001-4
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  • The aim of the present review was to summarize the current evidence on the role of ultrasonography (US) and doppler-US in the diagnosis of celiac disease.
  • Firstly, case control studies identified some of these US signs and then in a prospective series some of these parameters, due to their high specificity, have been shown to be of value in confirming CD diagnosis, whereas others, due to their high sensitivity, have been demonstrated to be useful in excluding the presence of the disease.
  • The last part of this review will deal with the possible role of US in identifying the most severe and common intestinal complication of CD, i.e. the enteropathy-associated T cell non-Hodgkin lymphoma.
  • [MeSH-minor] Abdomen / blood supply. Abdomen / ultrasonography. Adenocarcinoma / diagnosis. Adenocarcinoma / ultrasonography. Algorithms. Case-Control Studies. Humans. Intestinal Neoplasms / ultrasonography. Intestine, Small / ultrasonography. Lymphoma, Non-Hodgkin / ultrasonography. Prospective Studies. Splanchnic Circulation. Ultrasonography. Ultrasonography, Doppler / methods

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  • (PMID = 16534837.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC4087888
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41. Triantafillidis JK, Nasioulas G, Kosmidis PA: Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res; 2009 Jul;29(7):2727-37
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  • [Title] Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.
  • Patients with long-standing ulcerative colitis and Crohn's disease have an increased risk of developing colorectal cancer and patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.
  • Colorectal cancer appearing on the ground of inflammatory bowel disease is the result of a process which is believed to begin from no dysplasia progressing to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma, although colorectal cancer can arise without proceeding through each of these steps.
  • [MeSH-major] Cell Transformation, Neoplastic. Colorectal Neoplasms / epidemiology. Inflammatory Bowel Diseases / epidemiology

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  • (PMID = 19596953.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Number-of-references] 94
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42. Terado Y, Kurata A, Ishida T, Imamura T, Sakamoto A: Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma. Pathol Int; 2010 Oct;60(10):701-5
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  • [Title] Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma.
  • We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male.
  • Adenocarcinoma without stromal invasion was observed adjacent to the small intestinal mucosa.
  • Immunohistochemistry of the adenocarcinoma tissue revealed p53 overexpression and high Ki-67 labeling index as well as positive staining for CD10, cytokeratin 7, and cytokeratin 20.
  • Therefore, the diagnosis of small intestinal adenocarcinoma was made.
  • To our knowledge, this is the first case of small intestinal adenocarcinoma arising in retroperitoneal mature cystic teratoma.
  • A unique feature of this case is that malignant transformation in retroperitoneal mature teratoma arose even in the fully developed intestine.
  • [MeSH-major] Adenocarcinoma / pathology. Neoplasms, Multiple Primary / pathology. Retroperitoneal Neoplasms / pathology. Teratoma / pathology

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  • [Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
  • [ErratumIn] Pathol Int. 2010 Dec;60(12):798
  • (PMID = 20846270.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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43. Patel S, Liu D, Caron P, Seiter K: Acute myelogenous leukemia following irinotecan-based chemotherapy for adenocarcinoma of the small intestine. Leuk Lymphoma; 2007 May;48(5):1032-3
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  • [Title] Acute myelogenous leukemia following irinotecan-based chemotherapy for adenocarcinoma of the small intestine.
  • [MeSH-major] Adenocarcinoma / drug therapy. Camptothecin / analogs & derivatives. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology. Leukemia, Myeloid, Acute / drug therapy

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  • (PMID = 17487750.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; IFL protocol
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44. Friedrich-Rust M, Ell C: Early-stage small-bowel adenocarcinoma: a review of local endoscopic therapy. Endoscopy; 2005 Aug;37(8):755-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early-stage small-bowel adenocarcinoma: a review of local endoscopic therapy.
  • Early adenocarcinomas in the small intestine are a rare entity.
  • Most adenocarcinomas in the small intestine are diagnosed at a more advanced stage.
  • After surgical resection, only 3 - 10 % are found in stage T1 and 0 - 3 % in stage Tis (high-grade intraepithelial neoplasia), resulting in an overall 3 - 13 % rate of early-stage small-intestinal adenocarcinomas.
  • The diagnosis of early small-intestinal carcinoma by endoscopy is still very rare, although it will probably improve with the development of new endoscopic techniques.
  • [MeSH-major] Adenocarcinoma / surgery. Endoscopy, Gastrointestinal. Intestinal Neoplasms / surgery

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  • (PMID = 16032496.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 68
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45. Cheung DY, Lee IS, Chang DK, Kim JO, Cheon JH, Jang BI, Kim YS, Park CH, Lee KJ, Shim KN, Ryu JK, Do JH, Moon JS, Ye BD, Kim KJ, Lim YJ, Choi MG, Chun HJ, Korean Gut Images Study Group: Capsule endoscopy in small bowel tumors: a multicenter Korean study. J Gastroenterol Hepatol; 2010 Jun;25(6):1079-86
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  • [Title] Capsule endoscopy in small bowel tumors: a multicenter Korean study.
  • BACKGROUND AND AIM: Capsule endoscopy (CE) has proven to be highly effective at detecting small bowel lesions in a variety of clinical conditions, but studies concerning the practical impact of CE on small bowel tumors are still scarce, especially in the Asian population.
  • The aim of this study was to evaluate the diagnostic and therapeutic impact of CE in the field of small bowel tumors.
  • Clinical information and CE video images of small bowel tumors were analyzed.
  • Small bowel tumors were diagnosed with CE in 57 (4.3%) of 1332 patients.
  • The tumors were malignant in 33 cases, and included three adenocarcinomas, eight lymphomas, 20 gastrointestinal stromal tumors, and two metastatic cancers.
  • CONCLUSION: CE effectively identifies small bowel tumors that are undetectable by conventional radiological studies (diagnostic impact = 52.6%) and can critically change the therapeutic course (therapeutic impact = 12.3%).
  • [MeSH-major] Capsule Endoscopy / methods. Ileal Neoplasms / diagnosis. Intestine, Small. Jejunal Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / epidemiology. Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / epidemiology. Humans. Incidence. Korea / epidemiology. Lymphoma / diagnosis. Lymphoma / epidemiology. Male. Middle Aged. Reproducibility of Results. Retrospective Studies

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  • (PMID = 20594222.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Australia
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46. Farrell S, Gray SB, Best BG: Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature. Int Surg; 2005 Apr-Jun;90(2):85-7
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  • [Title] Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature.
  • Primary adenocarcinoma of the ileum is an uncommon gastrointestinal malignancy, the symptoms of which are often insidious in onset.
  • This case history highlights the previously unreported finding of ileal adenocarcinoma presenting with mucusuria, caused by local invasion of the bladder in a 44-year-old male.
  • A review of the literature is included to highlight the incidence, risk factors, clinical presentation, investigation, and current management of adenocarcinoma of the small bowel.
  • [MeSH-major] Adenocarcinoma / secondary. Ileal Neoplasms / pathology. Intestinal Fistula / diagnosis. Urinary Bladder Fistula / diagnosis. Urinary Bladder Neoplasms / secondary

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  • (PMID = 16119711.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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47. Bruckner HW, Hrehorovich VR, Sawhney HS, Meeus SI, Coopeman AM: Chemotherapeutic management of small bowel adenocarcinoma associated with Crohn's disease. J Chemother; 2006 Oct;18(5):545-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapeutic management of small bowel adenocarcinoma associated with Crohn's disease.
  • Four patients with metastatic primary small bowel adenocarcinoma associated with Crohn's disease were successfully treated with low dose combination chemotherapy consisting of 5-fluorouracil, leucovorin and irinotecan with or without gemcitabine.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Crohn Disease / complications. Duodenal Neoplasms / drug therapy. Ileal Neoplasms / drug therapy. Jejunal Neoplasms / drug therapy
  • [MeSH-minor] Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Female. Humans. Intestine, Small / pathology. Leucovorin / administration & dosage. Male. Remission Induction. Survival Analysis


48. Prodinger PM, Sarbia M, Massmann J, Straka C, Meyer G, Steinlein OK: Gorlin syndrome associated with small bowel carcinoma and mesenchymal proliferation of the gastrointestinal tract: case report and review of literature. BMC Cancer; 2010;10:360
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  • [Title] Gorlin syndrome associated with small bowel carcinoma and mesenchymal proliferation of the gastrointestinal tract: case report and review of literature.
  • BACKGROUND AND CASE PRESENTATION: A patient with nevoid basal cell carcinoma syndrome (Gorlin syndrome) presented with two unusual clinical features, i.e. adenocarcinoma of the small bowel and extensive mesenchymal proliferation of the lower gastrointestinal tract.
  • [MeSH-major] Basal Cell Nevus Syndrome / pathology. Cell Proliferation. Gastrointestinal Tract / pathology. Intestinal Neoplasms / pathology. Intestine, Small / pathology. Mesoderm / pathology

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  • (PMID = 20609239.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Cell Surface; 0 / patched receptors
  • [Other-IDs] NLM/ PMC2912266
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49. Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ: Small bowel adenocarcinoma. Curr Treat Options Oncol; 2008 Dec;9(4-6):388-99
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  • [Title] Small bowel adenocarcinoma.
  • Small bowel cancers are rare, accounting for only about 6000 cases/year in the United States, approximately 25% of which are small bowel adenocarcinomas.
  • Small bowel adenocarcinomas have traditionally been considered to be highly fatal due to their nonspecific presentation at the time of diagnosis, and to the lack of responsiveness to older chemotherapy regimens.
  • Newer diagnostic techniques such as video capsule and double balloon enteroscopy may facilitate earlier diagnosis.
  • Still, there remains great need for multi-institutional, cooperative group studies to define the optimal treatment of small bowel adenocarcinoma, both in the adjuvant and advanced/metastatic setting.
  • [MeSH-major] Adenocarcinoma / epidemiology. Intestinal Neoplasms / epidemiology
  • [MeSH-minor] Age of Onset. Animals. Antimetabolites, Antineoplastic / therapeutic use. Disease Models, Animal. Female. Fluorouracil / therapeutic use. Humans. Intestine, Small / pathology. Male. Mice. Middle Aged. Neoplasm Staging. Prognosis. Risk Factors. United States / epidemiology

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  • (PMID = 19365735.001).
  • [ISSN] 1534-6277
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
  • [Number-of-references] 40
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51. Lutz JC, El-Bouihi M, Vidal N, Fricain JC, Robert M, Deminière C, Zwetyenga N: Mandibular metastases from an ileum stromal tumor. Rev Stomatol Chir Maxillofac; 2008 Dec;109(6):399-402
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  • Jaw metastases from the gastrointestinal (GI) tract usually evolve from adenocarcinoma of the esophagus, colon, and rectum.
  • These tumors are thought to arise from Cajal cells in GI tract walls, essential for intestine motor function.
  • The small intestine harbors only 30% of GIST.
  • The patient was treated with imatinib but died 11 months after the diagnosis.
  • DISCUSSION: The prevalence of GIST is low but the true incidence may be higher because of under-diagnosis.
  • GIST should be included in the differential diagnosis of intramandibular tumor in patients with prior or current non-oral malignancy.

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  • (PMID = 19010506.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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52. Munday JS, Keenan JI, Beaugie CR, Sugiarto H: Ovine small intestinal adenocarcinomas are not associated with infection by herpesviruses, Helicobacter species or Mycobacterium avium subspecies paratuberculosis. J Comp Pathol; 2009 Feb-Apr;140(2-3):177-81
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  • [Title] Ovine small intestinal adenocarcinomas are not associated with infection by herpesviruses, Helicobacter species or Mycobacterium avium subspecies paratuberculosis.
  • Sheep in New Zealand more frequently develop small intestinal adenocarcinoma (SIA) than sheep in other countries.
  • The reasons for this high rate of intestinal neoplasia are not known.
  • This study compared rates of detection of herpesviruses, Helicobacter species, and Mycobacterium avium subspecies paratuberculosis (MAP) in ovine SIA to rates of detection in samples of intestine with non-neoplastic disease.
  • These infectious agents were chosen as all three have been associated with human intestinal cancer.
  • [MeSH-major] Adenocarcinoma / microbiology. Intestinal Neoplasms / microbiology. Sheep Diseases / microbiology

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  • (PMID = 19159897.001).
  • [ISSN] 1532-3129
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Bacterial
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53. Al-Brahim N, Ross C, Carter B, Chorneyko K: The value of postmortem examination in cases of metastasis of unknown origin-20-year retrospective data from a tertiary care center. Ann Diagn Pathol; 2005 Apr;9(2):77-80
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  • To evaluate the value of autopsy in determining the primary site of MUO, this study reviewed the Hamilton experience-over the last 20 years-with patients autopsied with clinical diagnosis of MUO.
  • METHODS: All autopsy diagnoses from cases performed at the Hamilton Health Sciences Center and St Joseph's Healthcare from 1980 to 2000 were reviewed.
  • Fifty-three cases of MUO were identified (MUO was defined as a patient with pathological and/or radiological diagnosis of a metastatic tumor for which the primary site of malignancy was unknown).
  • Pathological diagnoses at autopsy were adenocarcinoma (n = 37), small cell carcinoma (n = 6), anaplastic carcinoma (n = 3), and undifferentiated carcinoma (n = 3).
  • Primary tumors were identified in 27 patients (51%), most commonly in the lung (n = 8), large bowel (n = 6), and pancreas (n = 4).
  • Histochemical and immunohistochemical stains were helpful in reaching the diagnosis of a primary tumor in 4 of 27 cases.
  • (1) in this series, autopsy was helpful in establishing the diagnosis of a primary tumor in 51% of the cases, reaffirming the value of postmortem examination in these instances;.
  • (2) adenocarcinoma was the most frequent tumor presenting as MUO;.
  • (3) the lung and the large bowel were the most frequent sites for primary tumors; and (4) careful gross and histological examinations remain the most important tools in identifying the primary site.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Histocytochemistry / methods. Hospitals, University. Humans. Immunohistochemistry / methods. Intestinal Neoplasms / pathology. Intestine, Large. Lung Neoplasms / pathology. Male. Middle Aged. Pancreatic Neoplasms / pathology. Retrospective Studies. Staining and Labeling. Survival Analysis

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  • (PMID = 15806513.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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54. Liszka Ł, Zielińska-Pajak E, Pajak J, Gołka D, Huszno J: Coexistence of gastrointestinal stromal tumors with other neoplasms. J Gastroenterol; 2007 Aug;42(8):641-9
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  • The most common accompanying neoplasms were colorectal (nine cases) and gastric (four cases) adenocarcinoma, as well as pancreatic adenocarcinoma (three cases).
  • There was a tendency toward more common localization of a GIST in the small intestine in patients with other neoplasms than in patients with a GIST alone (P < 0.09).
  • A greater proportion of patients with a GIST localized in the small intestine and/or characterized by a very low risk of aggressive behavior and accompanying other neoplasms, compared with a GIST alone, most likely reflects the fact that in the first group, GISTs tended to be an incidental finding during surgery.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Colorectal Neoplasms / pathology. Gastrointestinal Stromal Tumors / pathology. Neoplasms, Multiple Primary / pathology. Pancreatic Neoplasms / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy. Confidence Intervals. Diagnosis, Differential. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Retrospective Studies


55. Baichi MM, Arifuddin RM, Mantry PS: Small-bowel masses found and missed on capsule endoscopy for obscure bleeding. Scand J Gastroenterol; 2007 Sep;42(9):1127-32
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  • [Title] Small-bowel masses found and missed on capsule endoscopy for obscure bleeding.
  • OBJECTIVE: Data on the nature of small-bowel tumors found or missed by capsule endoscopy (CE) are limited.
  • The aim of this study was to review the CE findings in patients with small-bowel tumors presenting as obscure gastrointestinal (GI) bleeding.
  • RESULTS: Ten (3%) confirmed small-bowel masses were found in 9 patients.
  • Most (80%) of the lesions were potentially malignant: adenocarcinoma (n=4), neuroendocrine carcinoma (n=1), leiomyosarcoma (n=1), and GI stroma cell tumors (GISTs) (n=2).
  • CE findings led directly to tumor diagnosis in 7 of the 10 cases.
  • CONCLUSIONS: Small-bowel tumors are a rare but serious source of obscure GI bleeding.
  • [MeSH-major] Capsule Endoscopy. Intestinal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Female. Gastrointestinal Hemorrhage / etiology. Humans. Intestine, Small. Male. Middle Aged. Retrospective Studies. Treatment Outcome


56. Shenderey RL, Thompson N, Mansfield JC, Rees C: Adenocarcinoma as a complication of small bowel Crohn's disease. Eur J Gastroenterol Hepatol; 2005 Nov;17(11):1255-7
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  • [Title] Adenocarcinoma as a complication of small bowel Crohn's disease.
  • Carcinoma is a recognized but rare complication of small bowel Crohn's disease.
  • This case series emphasizes the importance of considering this diagnosis in patients with small bowel Crohn's disease.
  • We report three cases in which patients were treated for presumed exacerbations of Crohn's, but were subsequently found to have underlying small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Crohn Disease / complications. Ileal Neoplasms / etiology. Jejunal Neoplasms / etiology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Intestinal Obstruction / etiology. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16215441.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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57. Xie J, Itzkowitz SH: Cancer in inflammatory bowel disease. World J Gastroenterol; 2008 Jan 21;14(3):378-89
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  • [Title] Cancer in inflammatory bowel disease.
  • Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC).
  • Colon cancer risk in inflammatory bowel disease increases with longer duration of colitis, greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of the bowel.
  • Patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.
  • Other extra intestinal cancers, such as hepatobiliary and hematopoietic cancer, have shown variable incidence rates.
  • [MeSH-major] Colorectal Neoplasms / physiopathology. Inflammatory Bowel Diseases / physiopathology. Neoplasms / physiopathology

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  • (PMID = 18200660.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 118
  • [Other-IDs] NLM/ PMC2679126
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58. Policarpio-Nicolas ML, Nicolas MM, Keh P, Laskin WB: Postradiation angiosarcoma of the small intestine: a case report and review of literature. Ann Diagn Pathol; 2006 Oct;10(5):301-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postradiation angiosarcoma of the small intestine: a case report and review of literature.
  • Postradiation angiosarcoma arising in the small intestine is rare with only 11 cases documented in the English-language literature.
  • Herein, we report a postradiation angiosarcoma of the small intestine 9 years after radiotherapy for uterine cervical adenocarcinoma.
  • The patient presented with symptoms of intestinal obstruction.
  • At exploratory laparotomy, tumor nodules involved the small bowel.
  • The diagnosis of angiosarcoma was confirmed immunohistochemically by tumor cell expression of CD31, CD34, and factor VIII-related antigen.
  • The diagnosis of PRA should be entertained for any poorly differentiated neoplasm arising in a previously irradiated site.
  • The correct diagnosis of PRA depends upon histomorphologic identification of vascular differentiation, coupled with immunohistochemical expression of endothelial-related markers.
  • [MeSH-major] Hemangiosarcoma / etiology. Intestinal Neoplasms / etiology. Intestine, Small. Neoplasms, Radiation-Induced / diagnosis
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Antigens, CD31 / metabolism. Antigens, CD34 / metabolism. Cell Transformation, Neoplastic / pathology. Factor VIII / metabolism. Fatal Outcome. Female. Gene Expression Regulation, Neoplastic. Humans. Intestinal Obstruction / etiology. Middle Aged. Prognosis. Uterine Cervical Neoplasms / radiotherapy

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  • (PMID = 16979525.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 9001-27-8 / Factor VIII
  • [Number-of-references] 17
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59. Ogata Y, Yamaguchi K, Sasatomi T, Uchida S, Akagi Y, Shirouzu K: [Treatment and outcome in small bowel cancer]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1454-7
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  • [Title] [Treatment and outcome in small bowel cancer].
  • In adenocarcinoma of the small intestine, delays in diagnosis are frequent, and the majority of patients present with advanced- stage disease and either lymph node involvement or distant metastatic disease.
  • Recent retrospective and prospective studies have helped to clarify the optimal chemotherapy approach for advanced small bowel adenocarcinoma.
  • The 72nd Japanese Society for Cancer of the Colon and Rectum have conducted a retrospective review of Japanese patients with adenocarcinoma of the jejunum or ileum.
  • The data indicated that although not statistically significant, there was a trend in median overall survival favoring the chemotherapy for advanced jejunal or ileal adenocarcinoma (17 months vs. 8 months, p=0.114).
  • [MeSH-major] Adenocarcinoma / therapy. Intestinal Neoplasms / therapy. Intestine, Small

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  • (PMID = 20716869.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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60. Suenaga M, Mizunuma N, Chin K, Matsusaka S, Shinozaki E, Oya M, Ueno M, Yamaguchi T, Muto T, Konishi F, Hatake K: Chemotherapy for small-bowel Adenocarcinoma at a single institution. Surg Today; 2009;39(1):27-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapy for small-bowel Adenocarcinoma at a single institution.
  • PURPOSE: Small-bowel adenocarcinoma (SBA) is rare.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Camptothecin / administration & dosage. Camptothecin / adverse effects. Camptothecin / analogs & derivatives. Disease Progression. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Follow-Up Studies. Humans. Intestine, Small / diagnostic imaging. Leucovorin / administration & dosage. Leucovorin / adverse effects. Male. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed. Vitamin B Complex / administration & dosage. Vitamin B Complex / adverse effects

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  • (PMID = 19132464.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0H43101T0J / irinotecan; 12001-76-2 / Vitamin B Complex; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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61. Zhang MQ, Chen ZM, Wang HL: Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma. Mod Pathol; 2006 Apr;19(4):573-80
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  • [Title] Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma.
  • Small intestinal adenocarcinoma is an uncommon neoplasm morphologically similar to or indistinguishable from colorectal adenocarcinoma.
  • Although much has been learned about genetic pathways critical to colorectal tumorigenesis, little is known about molecular alterations involved in the development of small intestinal adenocarcinoma.
  • In this study, we immunohistochemically compared non-ampullary small intestinal adenocarcinomas with sporadic colorectal adenocarcinomas for the expression of several proteins known to serve pivotal roles in colorectal tumorigenesis.
  • The results show that complete loss of adenomatous polyposis coli immunoreactivity, presumably resulting from its gene mutations, was observed in eight of 26 (31%) small intestinal adenocarcinomas and 36 of 51 (71%) colorectal adenocarcinomas (P = 0.0008).
  • Nuclear localization of beta-catenin, an indirect evidence of deregulated Wnt signaling pathway, was observed in 5 (19%) small intestinal adenocarcinomas and 36 (71%) colorectal adenocarcinomas (P<0.0001).
  • Total lack of nuclear staining for one or more of the DNA mismatch repair enzymes occurred in a similar low frequency in both small intestinal and colorectal adenocarcinomas, seen in two of 25 (8%) and 10 of 47 (21%) cases, respectively (P = 0.1958).
  • The frequencies of aberrant p53 and RB expression were also similar between small intestinal and colorectal adenocarcinomas.
  • These observations indicate that defects in the Wnt and microsatellite instability pathways occur in over 90% of colorectal adenocarcinomas, but in only 40% of small intestinal adenocarcinomas.
  • Small intestinal tumorigenesis appears to follow a distinct, yet unidentified, molecular pathway(s) from its colorectal counterpart despite their morphologic similarity.
  • [MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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  • (PMID = 16501564.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Retinoblastoma Protein; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
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62. von Rahden BH, Langner C, Brücher BL, Stein HJ, Sarbia M: No association of primary adenocarcinomas of the small bowel with Epstein-Barr virus infection. Mol Carcinog; 2006 May;45(5):349-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] No association of primary adenocarcinomas of the small bowel with Epstein-Barr virus infection.
  • Adenocarcinomas of the small bowel comprise a very rare entity, with little knowledge about molecular properties and etiological aspects.
  • We have investigated the prevalence of EBER expression (EBV-encoded small RNAs) in a series of small bowel adenocarcinomas (n=56) utilizing RNA in situ hybridization (EBER-RISH).
  • A surgical series of 82 primary resected gastric (n=36) or cardiac (n=46) adenocarcinomas (TU Munich) was used as control group.
  • None of the 56 small bowel carcinomas exhibited EBER expression whereas in the control group the rate of EBER expression accounted for 4.4% in the group of cardia carcinomas and 8.6% in the group of gastric cancers.
  • These results indicate that EBV infection plays no etiologic role in primary small bowel adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / virology. Epstein-Barr Virus Infections / virology. Herpesvirus 4, Human / genetics. Intestinal Neoplasms / virology. Intestine, Small / virology. Stomach Neoplasms / virology

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16493667.001).
  • [ISSN] 0899-1987
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral
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63. Sasaki Y, Natsuizaka M, Takano M, Suzuki M, Tsuyuguchi M, Nagasako T, Kawamura N, Kudo M, Tsuda I, Meguro J: [A case of primary adenocarcinoma of small intestine with multiple liver metastases successfully treated with mFOLFOX6]. Gan To Kagaku Ryoho; 2009 Nov;36(11):1927-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of primary adenocarcinoma of small intestine with multiple liver metastases successfully treated with mFOLFOX6].
  • Biopsy of the tumor was performed and pathological examination revealed adenocarcinoma.
  • Histopathological examination revealed moderately-differentiated adenocarcinoma of Bauhin's valve and the terminal ileum, and no adenocarcinoma was found in the cecum and ascending colon.
  • He was diagnosed with primary adenocarcinoma of the ileum with multiple liver metastases.
  • Effectiveness of mFOLFOX6 for primary adenocarcinoma of small intestine is suggested.
  • [MeSH-major] Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Ileal Neoplasms / pathology. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary

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  • (PMID = 19920403.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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64. Garrido A, Luque A, Vázquez A, Hernández JM, Alcántara F, Márquez JL: [Primary small bowel neoplasms as a complication of celiac disease]. Gastroenterol Hepatol; 2009 Nov;32(9):618-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary small bowel neoplasms as a complication of celiac disease].
  • [Transliterated title] Neoplasias primarias de intestino delgado como complicación de la enfermedad celíaca.
  • The most serious complication in these patients is the development of neoplasms, the most frequent being enteropathy-associated T-cell lymphoma; however, an increase in the incidence of small bowel adenocarcinoma has also been described.
  • We present two cases of small bowel carcinoma in patients with celiac disease, which were diagnosed at the onset of the disease.
  • [MeSH-major] Adenocarcinoma / etiology. Celiac Disease / complications. Duodenal Neoplasms / etiology. Ileal Neoplasms / etiology

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  • (PMID = 19625106.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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65. Lepage C, Bouvier AM, Manfredi S, Dancourt V, Faivre J: Incidence and management of primary malignant small bowel cancers: a well-defined French population study. Am J Gastroenterol; 2006 Dec;101(12):2826-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidence and management of primary malignant small bowel cancers: a well-defined French population study.
  • BACKGROUND AND AIM: Few data are available from population-based statistics on small bowel cancers.
  • Treatment and stage at diagnosis were investigated.
  • There were four main histological types: adenocarcinoma (40.4%), malignant endocrine tumors (30.5%), lymphoma (20.1%), and sarcoma (9.0%).
  • In the multivariate analysis, age, histology, and stage at diagnosis significantly influenced the prognosis.
  • CONCLUSIONS: Small bowel cancers represent a heterogeneous group of rare tumors.
  • [MeSH-major] Adenocarcinoma / epidemiology. Endocrine Gland Neoplasms / epidemiology. Intestinal Neoplasms / epidemiology. Intestine, Small. Lymphoma / epidemiology. Sarcoma / epidemiology

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  • (PMID = 17026561.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Athanassiou E, Vamvakopoulou DN, Zacharoulis D, Paroutoglou G, Sioutopoulou D, Tepetes K, Nomikos I, Vamvakopoulos NC: Immunophenotypic evaluation of DNA mismatch repair markers in 2 cases of synchronous histomorphologically distinct gastric adenocarcinomas with gastrointestinal stromal tumors of the proximal small bowel. Appl Immunohistochem Mol Morphol; 2010 May;18(3):288-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunophenotypic evaluation of DNA mismatch repair markers in 2 cases of synchronous histomorphologically distinct gastric adenocarcinomas with gastrointestinal stromal tumors of the proximal small bowel.
  • OBJECTIVES: To assess the prognostic value of combined mismatch DNA repair (MMR) phenotyping in 2 synchronous histomorphologically distinct gastric adenocarcinomas (GADCs), each accompanied by gastrointestinal stromal tumors (GISTs) of the proximal small bowel.
  • SUMMARY BACKGROUND DATA: A 72-year-old female and a 55-year-old male patient were submitted to partial and total gastrectomy, respectively, with synchronous resection of a GIST in the proximal small bowel.

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  • (PMID = 20090515.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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67. Krishnamurthy P, Varghese SE, Gopalswamy N, Hillman N, Ali SA: Small-bowel adenocarcinoma: case report and review of literature on diagnosis of small-bowel tumors. Gastroenterol Hepatol (N Y); 2007 Feb;3(2):129-35
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  • [Title] Small-bowel adenocarcinoma: case report and review of literature on diagnosis of small-bowel tumors.

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  • (PMID = 21960822.001).
  • [ISSN] 1554-7914
  • [Journal-full-title] Gastroenterology & hepatology
  • [ISO-abbreviation] Gastroenterol Hepatol (N Y)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3099353
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68. Chua TC, Koh JL, Yan TD, Liauw W, Morris DL: Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. J Surg Oncol; 2009 Aug 1;100(2):139-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma.
  • BACKGROUND: Small bowel adenocarcinoma is a rare malignancy that presents both a diagnostic and therapeutic challenge.
  • We review our experience with small bowel peritoneal carcinomatosis following treatment with cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC).
  • METHODS: From a prospective database of CRS and PIC, seven patients were identified to have undergone treatment for small bowel peritoneal carcinomatosis with CRS and hyperthermic intraperitoneal chemotherapy (Mitomycin C) and early postoperative intraperitoneal chemotherapy (5FU).
  • Tumor histology of poorly differentiated adenocarcinoma with signet ring, lymphovascular invasion and perineural invasion appeared to be associated with a poor outcome.
  • CONCLUSION: Cytoreductive surgery and perioperative intraperitoneal chemotherapy is a treatment option for small bowel cancer peritoneal carcinomatosis with encouraging survival results.
  • [MeSH-major] Adenocarcinoma / therapy. Hyperthermia, Induced. Ileal Neoplasms / therapy. Jejunal Neoplasms / therapy

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  • (PMID = 19544356.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Gibson MK, Holcroft CA, Kvols LK, Haller D: Phase II study of 5-fluorouracil, doxorubicin, and mitomycin C for metastatic small bowel adenocarcinoma. Oncologist; 2005 Feb;10(2):132-7
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  • [Title] Phase II study of 5-fluorouracil, doxorubicin, and mitomycin C for metastatic small bowel adenocarcinoma.
  • BACKGROUND: Small bowel adenocarcinoma is a rare gastrointestinal malignancy that is treated primarily with surgery.
  • This study aimed to document the response rate and survival time for patients with advanced small bowel adenocarcinoma who were not surgically curable and were treated with a regimen of 5-fluorouracil (5-FU), mitomycin C (Mutamycin; Bristol-Myers Squibb; Princeton, NJ), and doxorubicin (Adriamycin; Bedford Laboratories; Bedford, OH), the FAM regimen.
  • CONCLUSIONS: The FAM regimen was active and tolerable for patients with advanced small bowel adenocarcinoma; however, the results were no better than those seen with other chemotherapy combinations.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy

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  • (PMID = 15709215.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; 80168379AG / Doxorubicin; U3P01618RT / Fluorouracil
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70. Janot MS, Kersting S, Chromik AM, Tannapfel A, Uhl W: [Amyloidosis of the small intestine following whipple operation is a rare cause of chronic ileus and has to be considered as differential diagnosis]. Zentralbl Chir; 2010 Aug;135(4):345-9
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  • [Title] [Amyloidosis of the small intestine following whipple operation is a rare cause of chronic ileus and has to be considered as differential diagnosis].
  • [Transliterated title] Die Amyloidose des Dünndarms als seltene Differenzialdiagnose eines chronischen Ileus nach Whipple-Operation.
  • In this paper we report that secondary amyloidosis of the small intestine can produce similar symptoms and has to be evaluated as a rare differential diagnosis in chronic ileus.
  • Instead severe adhesions of the small intestine were detected.
  • The entire small intestine was covered with a substance that had a similar aspect to sugar icing.
  • Thereby the motility of the small intestine was constricted.
  • An extensive adhaesiolysis and a decompression of the bowel was carried out.
  • Diffuse amyloid deposits were found on the small intestine.
  • One man died four months later, after transfer to a geriatric hospital, because of intestinal atony and a serious senile depression.
  • Surgeons have to keep in mind that amyloidosis is a possible differential diagnosis in addition to relapse of tumour growth and peritoneal carcinomatosis in these patients.
  • [MeSH-major] Adenocarcinoma, Papillary / surgery. Amyloidosis / diagnosis. Cystadenoma, Mucinous / surgery. Ileus / diagnosis. Intestinal Diseases / diagnosis. Intestine, Small. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Postoperative Complications / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Chronic Disease. Diagnosis, Differential. Fatal Outcome. Female. Humans. Male. Tissue Adhesions / diagnosis. Tissue Adhesions / pathology. Tissue Adhesions / surgery

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  • [Copyright] Georg Thieme Verlag Stuttgart ˙ New York.
  • (PMID = 20464655.001).
  • [ISSN] 1438-9592
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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71. Jacks SP, Hundley JC, Shen P, Russell GB, Levine EA: Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. J Surg Oncol; 2005 Aug 1;91(2):112-7; discussion 118-9
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  • [Title] Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma.
  • Small bowel adenocarcinoma is a rare etiology for PC.
  • METHODS: From a prospective database of IPHC patients, six patients diagnosed with PC from adenocarcinoma of the small bowel were identified.
  • Median survival after diagnosis of small bowel adenocarcinoma was 54 months, while median survival after CS and IPHC for PC was 30.1 months.
  • CONCLUSIONS: Small bowel adenocarcinoma with PC remains an unusual therapeutic challenge.
  • [MeSH-major] Adenocarcinoma / drug therapy. Hyperthermia, Induced. Ileal Neoplasms / drug therapy. Jejunal Neoplasms / drug therapy. Peritoneal Neoplasms / drug therapy

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16028284.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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72. Nagashima Y, Okamoto H, Narita Y, Hida N, Naoki K, Kunikane H, Watanabe K: [Perforation of the small intestine caused by metastasis from primary lung cancer: report of two cases and the discussion of 48 cases published in the Japanese literature]. Nihon Kokyuki Gakkai Zasshi; 2007 May;45(5):430-5
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  • [Title] [Perforation of the small intestine caused by metastasis from primary lung cancer: report of two cases and the discussion of 48 cases published in the Japanese literature].
  • Case 1 was a 62-year-old man who had performance status (PS) of 1 and stage IIIB adenocarcinoma of the lung.
  • Three months after initial diagnosis, he complained of abdominal pain.
  • An operation was undertaken and the surgical findings showed perforation by small intestine metastasis from lung adenocarcinoma.
  • He underwent surgery and the surgical findings showed a metastasis of large cell carcinoma in the small intestine.
  • 48 operated cases with perforation caused by small intestine metastasis of lung cancer have been reported in full-length papers.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Carcinoma, Large Cell / pathology. Carcinoma, Large Cell / secondary. Intestinal Neoplasms / secondary. Intestinal Perforation / etiology. Intestine, Small. Lung Neoplasms / pathology

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  • (PMID = 17554989.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 5
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73. Kudo SE: New frontiers of endoscopy from the large intestine to the small intestine. Gastrointest Endosc; 2007 Sep;66(3 Suppl):S3-6
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  • [Title] New frontiers of endoscopy from the large intestine to the small intestine.
  • [MeSH-major] Colonoscopes. Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Intestinal Diseases / therapy. Intestine, Small
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / therapy. Capsule Endoscopy. Colitis, Ulcerative / diagnosis. Colitis, Ulcerative / pathology. Colitis, Ulcerative / therapy. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Colonic Neoplasms / therapy. Colonic Polyps / diagnosis. Colonic Polyps / pathology. Colonic Polyps / therapy. Equipment Design. Humans. Image Enhancement / instrumentation

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  • (PMID = 17709026.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Su MC, Yuan RH, Lin CY, Jeng YM: Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system. Mod Pathol; 2008 Nov;21(11):1379-86
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  • [Title] Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system.
  • Cadherin-17, also called liver-intestine cadherin, is a calcium-dependent transmembrane glycoprotein that mediates cell-cell adhesion in intestinal epithelium.
  • Expression of cadherin-17 was reported in gastric, pancreatic, and colorectal adenocarcinomas but not in other tumors.
  • Whether cadherin-17 can be used as a marker for diagnosis of cancers is still unclear.
  • Among normal tissues, the expression of cadherin-17 was limited to epithelial cells of small intestine and colon.
  • Colorectal adenocarcinomas showed staining in 96% of cases and most of them had strong and diffuse staining.
  • Gastric, pancreatic, and biliary adenocarcinomas showed diffuse or scattered staining in about 25-50% of cases.
  • When a two-marker, Cadherin-17/cytokeratin 7, profile was used, 37 of 38 (97%) cadherin-17(+)/cytokeratin 7(-) tumors were colorectal adenocarcinomas; 49 of 56 (86%) cadherin-17(+)/cytokeratin 7(+) tumors were gastric, pancreatic, or biliary adenocarcinomas.
  • Our results show that cadherin-17 is a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Cadherins / analysis. Gastrointestinal Neoplasms / diagnosis
  • [MeSH-minor] Colorectal Neoplasms / chemistry. Colorectal Neoplasms / diagnosis. Female. Humans. Immunoenzyme Techniques. Male. Pancreatic Neoplasms / chemistry. Pancreatic Neoplasms / diagnosis. Stomach Neoplasms / chemistry. Stomach Neoplasms / diagnosis

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  • (PMID = 18552820.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDH17 protein, human; 0 / Cadherins
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75. Yakan S, Caliskan C, Makay O, Denecli AG, Korkut MA: Intussusception in adults: clinical characteristics, diagnosis and operative strategies. World J Gastroenterol; 2009 Apr 28;15(16):1985-9
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  • [Title] Intussusception in adults: clinical characteristics, diagnosis and operative strategies.
  • AIM: To evaluate 20 adults with intussusception and to clarify the cause, clinical features, diagnosis, and management of this uncommon entity.
  • METHODS: A retrospective review of patients aged > 18 years with a diagnosis of intestinal intussusception between 2000 and 2008.
  • The majority of intussusceptions were in the small intestine (85%).
  • Among enteric intussusceptions, 14 were secondary to a benign process, and in one of these, the malignant cause was secondary to metastatic lung adenocarcinoma.
  • Treatment usually requires resection of the involved bowel segment.
  • Reduction can be attempted in small-bowel intussusception if the segment involved is viable or malignancy is not suspected; however, a more careful approach is recommended in colonic intussusception because of a significantly higher coexistence of malignancy.
  • [MeSH-major] Intussusception / diagnosis. Intussusception / surgery

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  • (PMID = 19399931.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2675089
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76. Ross A, Mehdizadeh S, Tokar J, Leighton JA, Kamal A, Chen A, Schembre D, Chen G, Binmoeller K, Kozarek R, Waxman I, Dye C, Gerson L, Harrison ME, Haluszka O, Lo S, Semrad C: Double balloon enteroscopy detects small bowel mass lesions missed by capsule endoscopy. Dig Dis Sci; 2008 Aug;53(8):2140-3
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  • [Title] Double balloon enteroscopy detects small bowel mass lesions missed by capsule endoscopy.
  • BACKGROUND: Small bowel mass lesions (SBML) are a relatively common cause of obscure gastrointestinal bleeding (OGIB).
  • Their detection has been limited by the inability to endoscopically examine the entire small intestine.
  • A small bowel mass lesion was identified in 18 patients.
  • Capsule endoscopy failed to identify all four cases of primary small bowel adenocarcinoma.
  • CONCLUSIONS: Double balloon enteroscopy detects small bowel mass lesions responsible for OGIB that are missed by CE.
  • Additional endoscopic evaluation of the small bowel by DBE or intraoperative enteroscopy should be performed in patients with ongoing OGIB and negative or non-specific findings on CE.
  • [MeSH-major] Capsule Endoscopy. Diagnostic Errors / prevention & control. Endoscopy, Gastrointestinal / methods. Gastrointestinal Hemorrhage / etiology. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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  • (PMID = 18270840.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] United States
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77. Agrawal S, McCarron EC, Gibbs JF, Nava HR, Wilding GE, Rajput A: Surgical management and outcome in primary adenocarcinoma of the small bowel. Ann Surg Oncol; 2007 Aug;14(8):2263-9
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  • [Title] Surgical management and outcome in primary adenocarcinoma of the small bowel.
  • BACKGROUND: Primary adenocarcinoma of the small bowel is a rare malignancy and is associated with poor survival outcome.
  • METHODS: Between 1971 and 2005, 64 patients with primary adenocarcinoma of the small bowel were treated at our institution.
  • RESULTS: The most common clinical features at presentation included abdominal pain (n = 33; 51.6%) or bowel obstruction (n = 20; 31.3%).
  • The most frequently involved portion of the small bowel was the duodenum (n = 41; 64%).
  • A segmental bowel resection was performed in 30 patients and pancreaticoduodenectomy in 14 patients.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / pathology. Intestinal Neoplasms / surgery

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  • (PMID = 17549572.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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78. Nicholl MB, Ahuja V, Conway WC, Vu VD, Sim MS, Singh G: Small bowel adenocarcinoma: understaged and undertreated? Ann Surg Oncol; 2010 Oct;17(10):2728-32
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  • [Title] Small bowel adenocarcinoma: understaged and undertreated?
  • BACKGROUND: Primary small bowel adenocarcinoma (SBA) is a rare, chemoresistant tumor with an aggressive clinical nature.
  • [MeSH-major] Intestinal Neoplasms / pathology. Intestine, Small / pathology. Lymph Nodes / pathology

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  • (PMID = 20458546.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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79. Beetham M, Khan MI: Incarceration of an umbilical hernia following colonoscopy. N Z Med J; 2009 Dec 11;122(1307):97-9
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  • We describe the unique case of a patient who developed incarceration of a loop of small bowel in an umbilical hernia following an uneventful diagnostic colonoscopy.
  • It was treated with laparotomy, with release of the incarcerated bowel and closure of the defect with nylon sutures.
  • [MeSH-major] Colonoscopy / adverse effects. Hernia, Umbilical / complications. Intestinal Obstruction / etiology. Intestinal Obstruction / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / ultrasonography. Aged. Anemia, Iron-Deficiency / diagnosis. Anemia, Iron-Deficiency / etiology. Colonic Neoplasms / diagnosis. Colonic Neoplasms / surgery. Female. Follow-Up Studies. Humans. Intestinal Volvulus. Intestine, Small / pathology. Laparotomy / methods. Risk Assessment. Treatment Outcome

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  • (PMID = 20148050.001).
  • [ISSN] 1175-8716
  • [Journal-full-title] The New Zealand medical journal
  • [ISO-abbreviation] N. Z. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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80. Safatle-Ribeiro AV, Kuga R, Ishida R, Furuya C, Ribeiro U Jr, Cecconello I, Ishioka S, Sakai P: Is double-balloon enteroscopy an accurate method to diagnose small-bowel disorders? Surg Endosc; 2007 Dec;21(12):2231-6
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  • [Title] Is double-balloon enteroscopy an accurate method to diagnose small-bowel disorders?
  • BACKGROUND AND STUDY AIMS: The aim of this study was to analyze the contribution of the double-balloon enteroscopy (DBE) for diagnosis of the small bowel disorders.
  • Other diagnoses included: duodenal adenocarcinoma, jejunal tuberculosis, erosions and ulcer of the jejunum.
  • Of 24 patients with other indications, the diagnosis could be achieved in 18 of them (75%), including: two lymphomas, plasmocytoma, Gardner's syndrome, Peutz-Jeghers' syndrome, familial adenomatous polyposis, Behçet's disease, jejunal submucosal lesion, lymphangiectasia due to blastomycosis and unspecific chronic jejunitis.
  • Additionally, two patients underwent DBE to exclude Crohn's disease and lymphoma of the small bowel.
  • The mean length of small bowel examination was 240 +/- 50 cm during a single approach.
  • DBE is a safe and and accurate method to diagnose small bowel disorders; 2. this method permits chromoscopy, biopsies and treatment of the lesions.
  • [MeSH-major] Catheterization. Endoscopy, Gastrointestinal / methods. Intestinal Diseases / diagnosis. Intestine, Small

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  • (PMID = 17593459.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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81. Zaanan A, Afchain P, Carrere N, Aparicio T: [Small bowel adenocarcinoma]. Gastroenterol Clin Biol; 2010 Aug-Sep;34(6-7):371-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Small bowel adenocarcinoma].
  • [Transliterated title] Adénocarcinome de l'intestin grêle.
  • Small bowel adenocarcinoma is a rare tumor.
  • Diagnosis is usually performed at an advanced stage because of non-specific nature of clinical manifestations.
  • New methods of radiological and endoscopic exploration of small intestine should allow earlier diagnosis.
  • A national prospective cohort study is currently evaluating the results of chemotherapy (recommended protocol: FOLFOX) as adjuvant and palliative treatment of small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Adenocarcinoma / therapy. Intestinal Neoplasms / etiology. Intestinal Neoplasms / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Genetic Predisposition to Disease. Humans. Intestine, Small / pathology. Intestine, Small / surgery. Lymphatic Metastasis. Neoplasm Metastasis. Prognosis. Risk Factors

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20537487.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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82. van Kouwen MC, Laverman P, van Krieken JH, Oyen WJ, Nagengast FM, Drenth JP: Noninvasive monitoring of colonic carcinogenesis: feasibility of [(18)F]FDG-PET in the azoxymethane model. Nucl Med Biol; 2006 Feb;33(2):245-8
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  • To address this issue, we studied the FDG uptake in AOM-induced rat colorectal adenocarcinoma (CRC) and correlated this with histopathological findings.
  • RESULTS: Macroscopic examination revealed 21 tumors (7 located in the small bowel and 14 in the colon) in 19 rats.
  • On histological examination, we found 10 colonic adenocarcinomas (the first being observed at Week 22) and 7 adenocarcinoma in the small bowel.
  • The [(18)F]FDG accumulation in small intestine carcinomas was well beyond background accumulation (P<.0001).
  • On PET scanning, two rats showed focal accumulation of the abdominal area, corresponding to small intestine carcinomas.
  • CONCLUSION: Adenocarcinomas had a significantly higher [(18)F]FDG uptake than background bowel uptake.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / radionuclide imaging. Colonic Neoplasms / metabolism. Colonic Neoplasms / radionuclide imaging. Disease Models, Animal. Fluorodeoxyglucose F18 / pharmacokinetics

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  • (PMID = 16546679.001).
  • [ISSN] 0969-8051
  • [Journal-full-title] Nuclear medicine and biology
  • [ISO-abbreviation] Nucl. Med. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; MO0N1J0SEN / Azoxymethane
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83. Mönkemüller K, Neumann H, Meyer F, Kuhn R, Malfertheiner P, Fry LC: A retrospective analysis of emergency double-balloon enteroscopy for small-bowel bleeding. Endoscopy; 2009 Aug;41(8):715-7
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  • [Title] A retrospective analysis of emergency double-balloon enteroscopy for small-bowel bleeding.
  • Although the role of emergency esophagogastroduodenoscopy (EGD) and colonoscopy for upper and lower gastrointestinal bleeding (GIB) is well defined, there are no data on the concept of emergency double-balloon enteroscopy (DBE) for small-bowel bleeding.
  • The following diagnoses were made: actively bleeding Dieulafoy lesions of the small bowel, n = 2; bleeding tumors, n = 4 (carcinoids n = 2, adenocarcinoma n = 1, lipoma n = 1); bleeding angiodysplasias and/or large arteriovenous malformation (AVM), n = 2; multiple ulcers, n = 1; and no diagnosis, n = 1.
  • It appears that emergency DBE is technically feasible, facilitates both diagnosis and therapy and enables management of patients with massive overt obscure GIB.
  • This study is a first step in establishing the concept of emergency DBE for patients with suspected small-bowel bleeding.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Feasibility Studies. Female. Humans. Intestine, Small / pathology. Male. Middle Aged. Retrospective Studies. Treatment Outcome


84. Erra S, Costamagna D, Botto G, Gemme C, Durando R: Sporadic flat ileal adenocarcinoma: an intriguing challenge in the comprehension of a rare neoplasia and its genesis. Case report and review of literature. G Chir; 2009 Mar;30(3):87-92
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  • [Title] Sporadic flat ileal adenocarcinoma: an intriguing challenge in the comprehension of a rare neoplasia and its genesis. Case report and review of literature.
  • Small bowel adenocarcinoma is a rare tumor, with a still not well studied tumorigenesis process, usually presenting in an advanced stage.
  • The clinical diagnosis is often difficult; surgery is the treatment of choice when feasible, while the chemotherapeutic approach is still not well standardized.
  • The gross appearance resembled an inflammatory bowel disease, but microscopic examination revealed the extensive presence of an infiltrating ileal adenocarcinoma.
  • Literature about small bowel adenocarcinoma has been reviewed for better understanding its pathogenesis.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Ileal Neoplasms / pathology. Ileal Neoplasms / surgery
  • [MeSH-minor] Aged. Anastomosis, Surgical. Diagnosis, Differential. Digestive System Surgical Procedures / methods. Humans. Male. Treatment Outcome

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  • (PMID = 19351457.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 44
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85. Breuhahn K, Singh S, Schirmacher P, Bläker H: Large-scale N-terminal deletions but not point mutations stabilize beta-catenin in small bowel carcinomas, suggesting divergent molecular pathways of small and large intestinal carcinogenesis. J Pathol; 2008 Jul;215(3):300-7
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  • [Title] Large-scale N-terminal deletions but not point mutations stabilize beta-catenin in small bowel carcinomas, suggesting divergent molecular pathways of small and large intestinal carcinogenesis.
  • Small intestinal adenocarcinoma is rare and its molecular pathogenesis is incompletely understood.
  • In order to elucidate the molecular background of beta-catenin stabilization in small intestinal adenocarcinoma, we investigated 20 non-familial adenomatous polyposis coli (FAP)-associated tumours, including five microsatellite-unstable carcinomas for beta-catenin alterations, by immunohistochemistry, western blot analysis and sequence analysis on the RNA and DNA levels.
  • Our data show that large intragenic CTNNB1 mutations stabilize beta-catenin in small intestinal adenocarcinomas and influence the subcellular distribution of the protein.
  • In contrast to colon carcinomas, neither APC nor CTNNB1 point mutations seem to play a significant role in carcinogenesis, indicating divergent mechanisms of wnt/wingless control in the small and the large intestine.
  • [MeSH-major] Adenocarcinoma / genetics. Intestinal Neoplasms / genetics. Sequence Deletion. beta Catenin / genetics

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  • [Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland.
  • (PMID = 18491352.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Wnt Proteins; 0 / beta Catenin
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86. Kersting S, Bruewer M, Laukoetter MG, Rijcken EM, Mennigen R, Buerger H, Senninger N, Krieglstein CF: Intestinal cancer in patients with Crohn's disease. Int J Colorectal Dis; 2007 Apr;22(4):411-7
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  • [Title] Intestinal cancer in patients with Crohn's disease.
  • BACKGROUND: Surveillance of intestinal cancer in Crohn's disease (CD) has often been advocated.
  • To date, no clear evidence exists whether CD patients are at special risk for intestinal cancer.
  • An increased incidence of small bowel adenocarcinoma is suggested.
  • We report our experience with 10 cases of CD complicated by intestinal adenocarcinoma.
  • Data of patients that developed carcinoma within Crohn's lesions of either small or large bowel were analyzed.
  • Mean age at the time of diagnosis of CD was 43 years.
  • Mean duration of CD until diagnosis of cancer was 14 years.
  • Delayed diagnosis resulted in a poor prognosis.
  • [MeSH-major] Crohn Disease / complications. Intestinal Neoplasms / etiology
  • [MeSH-minor] Adult. Colorectal Neoplasms. Databases, Factual. Female. Humans. Ileitis. Incidence. Intestinal Fistula. Male. Middle Aged. Survival Rate

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  • (PMID = 16847674.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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87. Czaykowski P, Hui D: Chemotherapy in small bowel adenocarcinoma: 10-year experience of the British Columbia Cancer Agency. Clin Oncol (R Coll Radiol); 2007 Mar;19(2):143-9
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  • [Title] Chemotherapy in small bowel adenocarcinoma: 10-year experience of the British Columbia Cancer Agency.
  • AIMS: Small bowel adenocarcinoma (SBA) is a rare, frequently lethal, malignancy.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestine, Small / drug effects

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  • (PMID = 17355111.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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88. Kobayashi K, Yano S, Kato K, Tatsukawa T, Ikeda T, Tokushima T: [Case with double primary cancers occurring synchronously in both the lung and jejunum diagnosed according to TTF-1 expression]. Nihon Kokyuki Gakkai Zasshi; 2005 Feb;43(2):84-8
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  • A 47-year-old man was diagnosed as having adenocarcinoma of the lung (T4N0M0) in August 2002.
  • Pathological examination of the lesion demonstrated adenocarcinoma.
  • The differential diagnosis between small intestine metastasis and primary small intestine cancer was difficult.
  • As adenocarcinoma of the jejunum was negative for TTF-1 in immunohistochemical staining and adenocarcinoma of the lung was positive, we diagnosed this patient as having primary jejunal cancer.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Intestine, Small. Jejunal Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Nuclear Proteins / analysis. Transcription Factors / analysis
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15770938.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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89. Cao J, Zuo Y, Lv F, Chen Z, Li J: Primary small intestinal malignant tumors: survival analysis of 48 postoperative patients. J Clin Gastroenterol; 2008 Feb;42(2):167-73
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  • [Title] Primary small intestinal malignant tumors: survival analysis of 48 postoperative patients.
  • BACKGROUND: Primary small intestinal malignant tumor is relatively uncommon compared to gastric and colorectal cancer.
  • It is difficult to make an early diagnosis due to the atypical primary symptoms and lack of effective diagnostic methods.
  • GOALS: To analyze the relationship between the prognoses, histologic type, and therapeutic strategy in postoperative patients with small intestinal tumor.
  • STUDY: The parameters that affect survival were evaluated using multivariate Cox analysis in 48 cases of small intestinal tumor (confirmed by operation and pathology) for the past 10 years.
  • The median time to progression for 8 patients with adenocarcinoma who received 5-fluorouracil or platinum-based palliative chemotherapy was 7 months, whereas for the patients who did not receive the therapy it was 3 months (P=0.06).
  • CONCLUSIONS: The prognosis for small intestinal malignancies is associated with clinical stage, and palliative chemotherapy with a 5-fluorouracil or platinum-based regimen offers a potential benefit to patients with adenocarcinoma.
  • Postoperative adjuvant chemotherapy seems to hold no therapeutic or survival benefit for patients with primary small bowel malignancies.
  • [MeSH-major] Intestinal Neoplasms / mortality. Intestinal Neoplasms / surgery. Intestine, Small / pathology

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  • (PMID = 18209587.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 49DFR088MY / Platinum; U3P01618RT / Fluorouracil
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90. Khelifi S, Bouhafa A, Agrebi W, Cherif A, Ben M, Khayat O, Letaief A: [Filiation hamartoma polyposis dysplasia and small bowel adenocarcinoma]. Tunis Med; 2006 Feb;84(2):128-30
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  • [Title] [Filiation hamartoma polyposis dysplasia and small bowel adenocarcinoma].
  • Transformation of the polyposis hamartoma into a site of dysplasia then into adenocarcinoma has been rarely reported.
  • [MeSH-major] Adenocarcinoma / complications. Ileal Neoplasms / complications. Peutz-Jeghers Syndrome / diagnosis

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  • (PMID = 16755980.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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91. Moran JA, Lemberger K, Cadoré JL, Lepage OM: Small intestine adenocarcinoma in conjunction with multiple adenomas causing acute colic in a horse. J Vet Diagn Invest; 2008 Jan;20(1):121-4
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  • [Title] Small intestine adenocarcinoma in conjunction with multiple adenomas causing acute colic in a horse.
  • An 11-year-old Andalusian stallion developed marked signs of colic associated with an acute small intestine obstruction.
  • Exploratory laparotomy revealed a distal jejunum full-thickness wall induration and multiple small adherent intraluminal masses.
  • Histologic examination revealed an adenocarcinoma and multiple polypoid adenomas.
  • Colic was considered secondary to partial jejunal lumen obstruction by the adenocarcinoma.
  • Adenocarcinoma recurrence or transformation from remaining adenomas into an adenocarcinoma is still a major risk.
  • [MeSH-major] Adenocarcinoma / veterinary. Colic / veterinary. Horse Diseases / pathology. Intestinal Neoplasms / veterinary. Intestine, Small / pathology

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  • (PMID = 18182527.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Ang D, Luman W, Ooi CJ: Early experience with double balloon enteroscopy: a leap forward for the gastroenterologist. Singapore Med J; 2007 Jan;48(1):50-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Double balloon enteroscopy (DBE) is a novel procedure that allows complete visualisation, biopsy and treatment of small intestinal disorders.
  • METHODS: Retrospective study of patients referred to the Department of Gastroenterology and Hepathology at the Singapore General Hospital for evaluation of suspected small bowel diseases between February 2005 and May 2006 was done.
  • A positive diagnosis was achieved in 19 patients: jejunal gastrointestinal stromal tumour (GIST) (one), jejunal sarcoma (one), jejunal adenocarcinoma (one), duodenal adenocarcinoma (one), malignant lymphangioma (one), eosinophilic enteritis (one), pseudomembranous ileitis (one), tuberculous ileitis (one), jejunitis/ileitis (seven), lymphangiectasia attributed to relapsed Non-Hodgkins lymphoma (one), combination of angiodysplastic lesions and apthous jejunal/ileal lesions (one), and focal villous atrophy (two).
  • Small intestinal pathology was excluded in three patients with abnormal computed tomography (CT) findings.
  • CONCLUSION: Our early experience with DBE shows it to be safe and effective in imaging the small intestine, and it may soon become a standard mode of investigation for the gastroenterologist.
  • [MeSH-major] Endoscopes, Gastrointestinal / standards. Endoscopy, Gastrointestinal / methods. Intestinal Diseases / diagnosis. Intestine, Small / pathology

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  • (PMID = 17245517.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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93. Mehta MV, Porecha MM, Mehta PJ: Small intestinal adenocarcinoma in Peutz-Jeghers syndrome. Indian J Gastroenterol; 2006 Jan-Feb;25(1):38-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small intestinal adenocarcinoma in Peutz-Jeghers syndrome.
  • Peutz-Jeghers syndrome (PJS) is characterized by intestinal hamartomatous polyposis (usually affecting the jejunum) and mucocutaneous melanin spots.
  • We report a 25-year-old man with PJS who developed small intestinal adenocarcinoma and presented with small bowel obstruction due to jejuno-ileal intussusception.
  • [MeSH-major] Adenocarcinoma / etiology. Jejunal Neoplasms / etiology. Peutz-Jeghers Syndrome / complications

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  • (PMID = 16567896.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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94. Kala Z, Válek V, Kysela P, Svoboda T: A shift in the diagnostics of the small intestine tumors. Eur J Radiol; 2007 May;62(2):160-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A shift in the diagnostics of the small intestine tumors.
  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • This work should answer the question, whether there is a method of making the diagnosis earlier when the disease is limited and easy to cure.
  • METHODOLOGY: A retrospective study comprising 96 patients having undergone surgery for a small intestine tumor in our hospital from 1996 to 2005 is presented.
  • In the year 1998 we changed our philosophy in trying to directly detect the small intestine pathology and not making the diagnosis by the exclusion only.
  • Intestinal ultrasound was performed on the Ultramark 3000 HDI device with autofocussable convex 5 MHz and linear 7.5 MHz probes or nowadays ATL 5000 HDI, 7-12 MHz linear probe.
  • RESULTS: We treated surgically 96 patients with the small intestine tumor.
  • A shift in the diagnostic algorithm was noticed in the bowel ultrasound now taking the lead.
  • CONCLUSION: The small bowel ultrasound can be recommended as the first choice method.
  • All patients with even very moderate abdominal symptoms ought to be examined for the small intestine pathology.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Abdomen, Acute / etiology. Abdomen, Acute / surgery. Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Aged. Algorithms. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Czech Republic. Endoscopy, Gastrointestinal. Endosonography. Female. Follow-Up Studies. Gastrointestinal Hemorrhage / etiology. Humans. Laparoscopy. Lymphoma / diagnosis. Lymphoma / surgery. Male. Melanoma / diagnosis. Melanoma / surgery. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17344005.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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95. Bergmann F, Singh S, Michel S, Kahlert C, Schirmacher P, Helmke B, Von Knebel Doeberitz M, Kloor M, Bläker H: Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway. Oncol Rep; 2010 Dec;24(6):1535-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway.
  • Celiac disease (CD) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma.
  • We hypothesized that CIM may link CD to small bowel carcinogenesis.
  • We determined microsatellite instability (MSI), CIM, and expression of MLH1 and MGMT in 3 CD-associated small bowel carcinomas and corresponding non-neoplastic mucosa.
  • The results were compared to those of small bowel mucosa from CD patients without carcinoma and 20 small bowel carcinomas from a non-CD origin.
  • In conclusion, our data reveal that the high-level CIM/MSI pathway is typical of CD-associated small bowel carcinomas and indicate that aberrant CpG island methylation links CD and carcinogenesis.
  • The data further suggest that CD should be considered in patients with small bowel adenocarcinoma, particularly when the tumors display MSI.
  • [MeSH-major] Adenocarcinoma / genetics. Celiac Disease / genetics. CpG Islands. DNA Methylation. Intestinal Neoplasms / genetics. Microsatellite Instability
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adult. Aged. Aged, 80 and over. Cohort Studies. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Humans. Intestinal Mucosa / metabolism. Intestinal Mucosa / pathology. Intestine, Small / metabolism. Intestine, Small / pathology. Male. Middle Aged. Nuclear Proteins / genetics. Signal Transduction / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 21042749.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
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96. Mastoraki A, Konstantiadou I, Papanikolaou I, Christodolou S, Sakorafas G, Peros G: Adenocarcinoma of the small intestine complicating Crohn's disease. Int J Colorectal Dis; 2009 Oct;24(10):1245-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the small intestine complicating Crohn's disease.
  • [MeSH-major] Adenocarcinoma / complications. Crohn Disease / complications. Intestinal Neoplasms / complications
  • [MeSH-minor] Adult. Aged. Humans. Incidence. Intestinal Obstruction / complications. Male. Middle Aged. Spondylitis, Ankylosing / complications

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  • (PMID = 19408004.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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97. Napolitano L, de Nicola P, Di Bartolomeo N, Aceto L, Liddo G, Angelucci D, Innocenti P: [A case of perforated small bowel adenocarcinoma as first symptom of Crohn's disease]. G Chir; 2005 May;26(5):212-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of perforated small bowel adenocarcinoma as first symptom of Crohn's disease].
  • [Transliterated title] Adenocarcinoma perforato del piccolo intestino come prima evidente manifestazione del morbo di Crohn: case report.
  • A case of perforated small bowel adenocarcinoma presenting as first symptom of Crohn's disease is reported in a 53 years old male patient with abdominal pain and alteration of bowel habits.
  • [MeSH-major] Adenocarcinoma / complications. Crohn Disease / diagnosis. Ileal Neoplasms / complications. Intestinal Perforation / etiology

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  • (PMID = 16184705.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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98. Agaimy A, Wünsch PH: Epithelioid and sarcomatoid malignant pleural mesothelioma in endoscopic gastric biopsies: a diagnostic pitfall. Pathol Res Pract; 2006;202(8):617-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To our knowledge, only three cases of epithelioid mesothelioma (EM) involving the luminal GI tract (intestine) have been reported so far, but no case of sarcomatoid MM (SM) involving the GI mucosa has been described.
  • We herein present the first two cases of MM (one each of EM and SM) of the pleura, presenting in endoscopic gastric biopsies as small polypoid lesions and poorly healing ulcers 30 and 35 months after the initial diagnosis of pleural MM, respectively.
  • The major differential diagnoses encompass primary or metastatic adenocarcinoma in case one and cytokeratin-positive (KIT negative!
  • [MeSH-major] Epithelioid Cells / pathology. Mesothelioma / pathology. Pleural Neoplasms / pathology. Sarcoma / pathology. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Aged. Biopsy. Carcinosarcoma / diagnosis. Endoscopy, Gastrointestinal. Fatal Outcome. Humans. Male. Stromal Cells / pathology


99. Overman MJ, Kopetz S, Wen S, Hoff PM, Fogelman D, Morris J, Abbruzzese JL, Ajani JA, Wolff RA: Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma. Cancer; 2008 Oct 15;113(8):2038-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma.
  • BACKGROUND: Metastatic small bowel adenocarcinoma (SBA) has a poor prognosis.
  • The primary tumor site was the jejunum in 35 patients (43%), duodenum in 30 patients (38%), ileum in 6 patients (8%), and nonspecified small bowel in 9 patients (11%).
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestine, Small / pathology

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18759326.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platinum Compounds; U3P01618RT / Fluorouracil
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100. Postgate A, Despott E, Burling D, Gupta A, Phillips R, O'Beirne J, Patch D, Fraser C: Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy. Gastrointest Endosc; 2008 Dec;68(6):1209-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy.
  • BACKGROUND: Capsule endoscopy (CE) is considered a first-line investigation for obscure GI bleeding (OGIB) and small-bowel polyp or tumor detection.
  • The reliability of a negative CE in excluding gross small-bowel pathology remains unclear.
  • OBJECTIVE: We describe our experience of significant small-bowel pathology missed at CE in 5 patients.
  • PATIENTS: Five patients were evaluated: 4 with a history of OGIB (transfusion dependent in 2) and 1 patient with Peutz-Jeghers syndrome (PJS) under small-bowel surveillance.
  • MAIN OUTCOME MEASUREMENTS: Detection of significant small-bowel pathology by using DBE, CT, or MRE after a negative capsule study.
  • RESULTS: Significant small-bowel pathology was missed at CE but was detected by alternative modalities in 5 patients.
  • In 4 patients, the lesions were in the proximal small bowel (adenocarcinoma, malignant melanoma, varices, and stromal tumor).
  • LIMITATIONS: Retrospective case series with small numbers.
  • CONCLUSIONS: Gross pathology may be missed at CE, especially in the proximal small bowel, and a negative CE study does not exclude significant disease.
  • [MeSH-major] Capsule Endoscopy. Endoscopy, Gastrointestinal. Intestinal Diseases / diagnosis. Intestine, Small / pathology. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • [CommentIn] Gastrointest Endosc. 2008 Dec;68(6):1128-30 [19028221.001]
  • [CommentIn] Gastrointest Endosc. 2009 Oct;70(4):819; author reply 819-20 [19788994.001]
  • (PMID = 19028234.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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