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1. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. Int J Toxicol; 2007;26 Suppl 1:3-106
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  • The ultraviolet (UV) absorption spectrum for Capsicum Annuum Fruit Extract indicates a small peak at approximately 275 nm, and a gradual increase in absorbance, beginning at approximately 400 nm.
  • In an 8-week feeding study using rats, intestinal exfoliation, cytoplasmic fatty vacuolation and centrilobular necrosis of hepatocytes, and aggregation of lymphocytes in the portal areas were seen at 10% Capsicum Frutescens Fruit, but not 2%.
  • Adenocarcinoma of the abdomen was observed in 7/20 mice fed 100 mg red chilies per day for 12 months; no tumors were seen in control animals.
  • Neoplastic changes in the liver and intestinal tumors were observed in rats fed red chili powder at 80 mg/kg day-1 for 30 days, intestinal and colon tumors were seen in rats fed red chili powder and 1,2-dimethyl hydrazine, but no tumors were observed in controls.
  • Ingested Capsaicin is rapidly absorbed from the stomach and small intestine in animal studies.

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  • (PMID = 17365137.001).
  • [ISSN] 1091-5818
  • [Journal-full-title] International journal of toxicology
  • [ISO-abbreviation] Int. J. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cosmetics; 0 / Plant Extracts; 0 / Resins, Plant; S07O44R1ZM / Capsaicin
  • [Number-of-references] 462
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2. Gonda TA, Khan SU, Cheng J, Lewis SK, Rubin M, Green PH: Association of intussusception and celiac disease in adults. Dig Dis Sci; 2010 Oct;55(10):2899-903
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  • Two patients were found to have lead-point intussusceptions and both had small-bowel adenocarcinoma, and 10/14 had severe villous atrophy (subtotal or total).
  • Among those with established celiac disease, IS was detected early, within 3 years of diagnosis.
  • Adenocarcinoma needs to be excluded.
  • [MeSH-minor] Abdominal Pain / epidemiology. Abdominal Pain / pathology. Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adult. Atrophy. Biopsy. Capsule Endoscopy. Chi-Square Distribution. Databases, Factual. Female. Follow-Up Studies. Humans. Incidental Findings. Intestinal Neoplasms / epidemiology. Intestinal Neoplasms / pathology. Male. Middle Aged

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  • (PMID = 20033844.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. He YT, Wang XJ, Gong J, Chen N, Zhou Q: Primary adenosquamous carcinoma of the jejunum. Pathol Int; 2005 Sep;55(9):590-5
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  • Adenosquamous carcinomas of the small intestine are extremely rare, with only three documented jejunal and three ileal cases being reported in the English-language medical literature.
  • The jejunal carcinoma consisted predominantly of a squamous component throughout the tumor but peritoneal nodules carrying metastases from the adenocarcinoma element were noted, making it the first case of jejunal adenosquamous carcinoma with metastases from the adenocarcinoma component.
  • The finding that metastases could arise from the minor component of a jejunal adenosquamous carcinoma indicates that an accurate diagnosis must be based upon thorough examination of both the primary and the metastases, not just mesenteric nodule biopsy alone.
  • The squamous component was strongly positive with immunostaining for p63 (nuclear staining) and for cytokeratin 10/13 (cytoplasmic staining), while the adenocarcinoma element was negative.

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  • (PMID = 16143036.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 68238-35-7 / Keratins
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4. von Rahden BH, Langner C, Brücher BL, Stein HJ, Sarbia M: No association of primary adenocarcinomas of the small bowel with Epstein-Barr virus infection. Mol Carcinog; 2006 May;45(5):349-52
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  • [Title] No association of primary adenocarcinomas of the small bowel with Epstein-Barr virus infection.
  • Adenocarcinomas of the small bowel comprise a very rare entity, with little knowledge about molecular properties and etiological aspects.
  • We have investigated the prevalence of EBER expression (EBV-encoded small RNAs) in a series of small bowel adenocarcinomas (n=56) utilizing RNA in situ hybridization (EBER-RISH).
  • A surgical series of 82 primary resected gastric (n=36) or cardiac (n=46) adenocarcinomas (TU Munich) was used as control group.
  • None of the 56 small bowel carcinomas exhibited EBER expression whereas in the control group the rate of EBER expression accounted for 4.4% in the group of cardia carcinomas and 8.6% in the group of gastric cancers.
  • These results indicate that EBV infection plays no etiologic role in primary small bowel adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / virology. Epstein-Barr Virus Infections / virology. Herpesvirus 4, Human / genetics. Intestinal Neoplasms / virology. Intestine, Small / virology. Stomach Neoplasms / virology

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16493667.001).
  • [ISSN] 0899-1987
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral
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5. van der Weyden L, Arends MJ, Dovey OM, Harrison HL, Lefebvre G, Conte N, Gergely FV, Bradley A, Adams DJ: Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis. Oncogene; 2008 Jul 24;27(32):4503-8
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  • [Title] Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis.
  • In this study we set out to test the hypothesis that loss of Rassf1a can cooperate with inactivation of the adenomatous polyposis coli (Apc) gene to accelerate intestinal tumourigenesis using the Apc-Min (Apc(Min/+)) mouse model, as mutational or deletional inactivation of APC is a frequent early event in the genesis of intestinal cancer.
  • Further, loss of RASSF1A has also been reported to occur in premalignant adenomas of the bowel.
  • By interbreeding isoform specific Rassf1a knockout mice with Apc(+/Min) mice, we showed that loss of Rassf1a results in a significant increase in adenomas of the small intestine and accelerated intestinal tumourigenesis leading to the earlier death of adenocarcinoma-bearing mice and decreased overall survival.
  • Collectively these data demonstrate cooperation between inactivation of Rassf1a and Apc resulting in accelerated intestinal tumourigenesis, with adenomas showing increased nuclear accumulation of beta-catenin, supporting a mechanistic link via loss of the known interaction of Rassf1 with beta-TrCP that usually mediates degradation of beta-catenin.
  • [MeSH-major] Genes, APC. Intestinal Neoplasms / etiology. Tumor Suppressor Proteins / physiology

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  • (PMID = 18391979.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 079643; United Kingdom / Cancer Research UK / / A8449; United Kingdom / Cancer Research UK / / ; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Mki67 protein, mouse; 0 / RASSF1 protein, mouse; 0 / Tumor Suppressor Proteins; 0 / beta Catenin
  • [Other-IDs] NLM/ EMS52273; NLM/ PMC3706934
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6. Manfredi S, Thiebot T, Henno S, Falize L, Bretagne JF, Meunier B: Complete response of an initially non-surgical adenocarcinoma of the duodenum to chemotherapy with the FOLFOX 4 regimen. J Gastrointest Surg; 2009 Dec;13(12):2309-13
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  • [Title] Complete response of an initially non-surgical adenocarcinoma of the duodenum to chemotherapy with the FOLFOX 4 regimen.
  • INTRODUCTION: The incidence of adenocarcinoma of the small bowel is very low in comparison with that of colorectal cancer.
  • No standard chemotherapy is defined for non-surgical adenocarcinoma of the small bowel.
  • CASE REPORT: We report here the case of a young patient with an initially non-surgical adenocarcinoma of the duodenum treated in a palliative setting with the FOLFOX 4 chemotherapy regimen.
  • CONCLUSION: The FOLFOX 4 regimen seems to be efficacious for some small-bowel adenocarcinomas and can be expected to lead to downstaging.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy

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  • (PMID = 19585173.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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7. Sumrall A, Soni N: Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association? Int J Gastrointest Cancer; 2006;37(4):146-8
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  • [Title] Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association?
  • After surgical excision and radiotherapy of dermatofibrosarcoma protuberans, the patient developed small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Dermatofibrosarcoma / pathology. Intestinal Neoplasms / pathology. Neoplasms, Second Primary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Intestine, Small / diagnostic imaging. Intestine, Small / pathology. Male. Radiography. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 18175227.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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8. Liu W, Zhu J, Cao L, Rodgers GP: Expression of hGC-1 is correlated with differentiation of gastric carcinoma. Histopathology; 2007 Aug;51(2):157-65
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  • Using immunohistochemistry, it was demonstrated that hGC-1 is expressed in the oesophagus, stomach, small intestine and colon.
  • Enhanced hGC-1 expression was more frequently seen in intestinal-type adenocarcinoma, whereas loss of expression tended to occur in the diffuse type. hGC-1 was highly expressed in well or moderately differentiated cancers and was remarkably reduced or lost in poorly differentiated or undifferentiated tumours.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Cell Differentiation. Gastrointestinal Tract / metabolism. Gene Expression. Humans. Immunohistochemistry. Protein Array Analysis

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  • (PMID = 17650212.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / OLFM4 protein, human; 143011-72-7 / Granulocyte Colony-Stimulating Factor
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9. Ko S, Chu KM, Luk JM, Wong BW, Yuen ST, Leung SY, Wong J: CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach. J Pathol; 2005 Apr;205(5):615-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach.
  • CDX2 and liver-intestine (LI)-cadherin are intestine-specific markers and both are physiologically expressed in the small intestine and colon.
  • Overexpression of CDX2 was significantly associated with CDH17 in gastric adenocarcinoma.
  • Furthermore, the expression of CDX2 and LI-cadherin proteins was strongly coupled in intestinal metaplasia.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Cadherins / metabolism. Homeodomain Proteins / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 15732140.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDH17 protein, human; 0 / CDX2 protein, human; 0 / Cadherins; 0 / Homeodomain Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger
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10. Wu TJ, Yeh CN, Chao TC, Jan YY, Chen MF: Prognostic factors of primary small bowel adenocarcinoma: univariate and multivariate analysis. World J Surg; 2006 Mar;30(3):391-8; discussion 399
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors of primary small bowel adenocarcinoma: univariate and multivariate analysis.
  • BACKGROUND: Adenocarcinoma of the small bowel is relatively less common than malignancies of the esophagus, stomach, and colorectum.
  • In small bowel adenocarcinoma, various prognostic factors influence the disease-free status and overall survival rates.
  • MATERIALS AND METHODS: Eighty patients who were diagnosed with small bowel adenocarcinoma and treated at our institute between 1983 and 2003 were retrospectively reviewed.
  • CONCLUSIONS: Poor prognosis of small bowel adenocarcinoma may be related to a delay in the diagnosis and treatment of the disease.
  • Curative resection is the aim of surgical treatment for small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small

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  • (PMID = 16479330.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Kala Z, Válek V, Kysela P, Svoboda T: A shift in the diagnostics of the small intestine tumors. Eur J Radiol; 2007 May;62(2):160-5
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  • [Title] A shift in the diagnostics of the small intestine tumors.
  • Primary, secondary, benign or malignant tumorous diseases of the small intestine are rare.
  • This work should answer the question, whether there is a method of making the diagnosis earlier when the disease is limited and easy to cure.
  • METHODOLOGY: A retrospective study comprising 96 patients having undergone surgery for a small intestine tumor in our hospital from 1996 to 2005 is presented.
  • In the year 1998 we changed our philosophy in trying to directly detect the small intestine pathology and not making the diagnosis by the exclusion only.
  • Intestinal ultrasound was performed on the Ultramark 3000 HDI device with autofocussable convex 5 MHz and linear 7.5 MHz probes or nowadays ATL 5000 HDI, 7-12 MHz linear probe.
  • RESULTS: We treated surgically 96 patients with the small intestine tumor.
  • A shift in the diagnostic algorithm was noticed in the bowel ultrasound now taking the lead.
  • CONCLUSION: The small bowel ultrasound can be recommended as the first choice method.
  • All patients with even very moderate abdominal symptoms ought to be examined for the small intestine pathology.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / surgery. Intestine, Small / pathology. Intestine, Small / surgery
  • [MeSH-minor] Abdomen, Acute / etiology. Abdomen, Acute / surgery. Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Aged. Algorithms. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Czech Republic. Endoscopy, Gastrointestinal. Endosonography. Female. Follow-Up Studies. Gastrointestinal Hemorrhage / etiology. Humans. Laparoscopy. Lymphoma / diagnosis. Lymphoma / surgery. Male. Melanoma / diagnosis. Melanoma / surgery. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17344005.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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12. Chong AK, Chin BW, Meredith CG: Clinically significant small-bowel pathology identified by double-balloon enteroscopy but missed by capsule endoscopy. Gastrointest Endosc; 2006 Sep;64(3):445-9
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  • [Title] Clinically significant small-bowel pathology identified by double-balloon enteroscopy but missed by capsule endoscopy.
  • BACKGROUND: Capsule endoscopy (CE) is increasingly being used to investigate the small bowel for various indications, including obscure GI bleeding (OGB).
  • Double-balloon enteroscopy (DBE) is a new endoscopic technique developed to potentially view the entire small intestine while allowing therapeutic options to be carried out when appropriate.
  • OBJECTIVE: We described 4 patients with small-bowel pathology missed on CE but detected by DBE.
  • INTERVENTIONS: DBE followed by surgical exploration and resection of small-bowel pathology.
  • Definitive treatment of small-bowel pathology by surgical resection.
  • RESULTS: CE did not identify the small-bowel pathology in all 4 patients.
  • The 3 patients with OGB had small-bowel masses found by DBE.
  • Two of these were GI stromal tumors and one was an adenocarcinoma.
  • LIMITATIONS: Retrospective study and small sample size.
  • If there is a high index of suspicion of small-bowel pathology despite a negative CE, DBE should be performed.
  • [MeSH-major] Endoscopy, Gastrointestinal / methods. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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  • (PMID = 16923502.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Popnikolov NK, Gatalica Z, Adegboyega PA, Norris BA, Pasricha PJ: Downregulation of TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L in Barrett's esophagus with dysplasia and adenocarcinoma. Appl Immunohistochem Mol Morphol; 2006 Jun;14(2):161-5
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  • [Title] Downregulation of TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L in Barrett's esophagus with dysplasia and adenocarcinoma.
  • The aim of this study was to compare TRAIL/Apo2L expression in normal gastroesophageal (GE) junction, Barrett's esophagus with and without dysplasia, and associated adenocarcinoma.
  • Immunohistochemical evaluation of TRAIL expression was performed on formalin-fixed paraffin-embedded sections from 29 GE junction/esophageal biopsies, 20 gastric biopsies, 6 esophagectomies, 2 small bowel resection specimens, and 5 colon biopsies.
  • TRAIL was expressed in the foveolar epithelium of the histologically normal GE junctional mucosa and stomach as well as in the normal intestinal epithelium, with maximal expression in the surface epithelium.
  • TRAIL was rarely and weakly (1+) expressed in Barrett's esophagus with dysplasia (3/18, 16.7%) and adenocarcinoma (1/10, 10.0%) (P<0.001).
  • Similarities in the topographic pattern of TRAIL expression in the normal GE junction, stomach, small intestine, and colon suggest a common function of TRAIL throughout the gastrointestinal tract.

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  • (PMID = 16785783.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TNF-Related Apoptosis-Inducing Ligand
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14. Caruso S, Marrelli D, Pedrazzani C, Neri A, Mazzei MA, Onorati M, Corso G, Cerullo G, Roviello F: A rare case of primary small bowel adenocarcinoma with intussusception. Tumori; 2010 Mar-Apr;96(2):355-7
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  • [Title] A rare case of primary small bowel adenocarcinoma with intussusception.
  • In contrast with the colon tract, the incidence of primary malignancies in the small bowel is very low.
  • We report the case of a 51-year-old man presenting with jejunal intussusception due to a primary adenocarcinoma.
  • The patient was referred to our division for bowel obstruction.
  • Histological examination of the specimen resulted in a diagnosis of a primary adenocarcinoma of the small bowel.
  • In adult intestinal intussusception, resection without reduction is considered the optimal management if an underlying primary malignancy cannot be excluded.
  • [MeSH-major] Adenocarcinoma / complications. Intussusception / etiology. Jejunal Diseases / etiology. Jejunal Neoplasms / complications

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  • (PMID = 20572601.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Gao C, Wang AY: Significance of increased apoptosis and Bax expression in human small intestinal adenocarcinoma. J Histochem Cytochem; 2009 Dec;57(12):1139-48
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  • [Title] Significance of increased apoptosis and Bax expression in human small intestinal adenocarcinoma.
  • Human small intestine accounts for 75% of the gastrointestinal (GI) length but for only 1-5% of GI tumors.
  • For this purpose, 77 samples from patients were examined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and immunohistochemistry, including 40 cases from normal small intestine (jejunum), 7 cases from jejunum and ileum adenocarcinomas, and 30 cases from normal colon.
  • The results showed that a significantly higher level of enterocyte apoptosis was observed in normal small intestine compared with small intestinal adenocarcinomas and normal colon (median of apoptotic index, 15.2% vs 0.1% and 1.6%, p<0.01).
  • In conclusion, increased apoptosis and expression of Bax, not Bcl-2 or the Bax/Bcl-2 ratio, may play some role in the relatively lower incidence of human small intestinal carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Apoptosis. Gene Expression Regulation, Neoplastic. Intestinal Neoplasms / pathology. Intestine, Small / metabolism. Intestine, Small / pathology. bcl-2-Associated X Protein / metabolism

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  • (PMID = 19729672.001).
  • [ISSN] 1551-5044
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / bcl-2-Associated X Protein
  • [Other-IDs] NLM/ PMC2778087
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16. Zaanan A, Afchain P, Carrere N, Aparicio T: [Small bowel adenocarcinoma]. Gastroenterol Clin Biol; 2010 Aug-Sep;34(6-7):371-9
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  • [Title] [Small bowel adenocarcinoma].
  • [Transliterated title] Adénocarcinome de l'intestin grêle.
  • Small bowel adenocarcinoma is a rare tumor.
  • Diagnosis is usually performed at an advanced stage because of non-specific nature of clinical manifestations.
  • New methods of radiological and endoscopic exploration of small intestine should allow earlier diagnosis.
  • A national prospective cohort study is currently evaluating the results of chemotherapy (recommended protocol: FOLFOX) as adjuvant and palliative treatment of small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Adenocarcinoma / therapy. Intestinal Neoplasms / etiology. Intestinal Neoplasms / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Genetic Predisposition to Disease. Humans. Intestine, Small / pathology. Intestine, Small / surgery. Lymphatic Metastasis. Neoplasm Metastasis. Prognosis. Risk Factors

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20537487.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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17. Wang C, Zhou XG: [Role of CDX2 immunostaining in diagnosis of gastrointestinal adenocarcinoma]. Zhonghua Bing Li Xue Za Zhi; 2006 Apr;35(4):228-31
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  • [Title] [Role of CDX2 immunostaining in diagnosis of gastrointestinal adenocarcinoma].
  • OBJECTIVE: To study the expression of CDX2 in normal and tumor tissues, and to evaluate the value of CDX2 immunostaining in the diagnosis of gastrointestinal adenocarcinoma.
  • RESULTS: CDX2 was strongly expressed in surface epithelium of 13 samples of normal intestine and in ductal epithelium of 8 samples of normal pancreas, as well as in 47 samples (92.2%) of colonic adenocarcinoma and 58 samples (66.9%) of gastric adenocarcinoma.
  • The positivity rates were as follows: ovarian mucinous adenocarcinoma 15.6% (10/64), pancreatic cancer 33.3% (3/9), thyroid cancer 27.3% (3/11) and extrahepatic biliary cancer 25% (4/16).
  • CONCLUSIONS: CDX2 is expressed mainly in normal epithelium of intestinal tract and small pancreatic ducts, as well as in primary adenocarcinoma of gastrointestinal tract.
  • CDX2 may thus play an important role in distinguishing primary non-intestinal adenocarcinoma from metastatic adenocarcinoma of gastric or colorectal primary.
  • [MeSH-major] Adenocarcinoma / diagnosis. Gastrointestinal Neoplasms / diagnosis. Homeodomain Proteins / metabolism
  • [MeSH-minor] Colonic Neoplasms / diagnosis. Colonic Neoplasms / metabolism. Female. Gastrointestinal Tract / chemistry. Gastrointestinal Tract / pathology. Humans. Immunohistochemistry. Male. Stomach Neoplasms / diagnosis. Stomach Neoplasms / metabolism. Tissue Array Analysis

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  • (PMID = 16776981.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins
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18. Lenaerts K, Bouwman FG, Lamers WH, Renes J, Mariman EC: Comparative proteomic analysis of cell lines and scrapings of the human intestinal epithelium. BMC Genomics; 2007;8:91
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  • [Title] Comparative proteomic analysis of cell lines and scrapings of the human intestinal epithelium.
  • The Caco-2 cell line, originating from a colon carcinoma, is a widely used in vitro model for small intestinal epithelium.
  • This study was designed to compare the protein expression pattern of Caco-2 cells with the patterns of intestinal epithelial cells from human small and large intestine.
  • HT-29 intestinal cells, Hep G2 liver cells and TE 671 muscle cells were included too, the latter two as negative controls.
  • Principal component and cluster analysis revealed that global expression of intestinal epithelial scrapings differed from that of intestinal epithelial cell lines.
  • When investigating the profiles of Caco-2 cells and small intestinal cells in detail, a considerable overlap was observed.
  • CONCLUSION: Numerous proteins showed a similar expression in Caco-2 cells, HT-29 cells, and both the intestinal scrapings, of which some appear to be characteristic to human intestinal epithelium in vivo.
  • In addition, several biologically significant proteins are expressed at comparable levels in Caco-2 cells and small intestinal scrapings, indicating the usability of this in vitro model.
  • [MeSH-major] Intestinal Mucosa / chemistry. Intestinal Mucosa / pathology. Proteins / analysis. Proteomics
  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / genetics. Adenocarcinoma / pathology. Caco-2 Cells. Cell Culture Techniques. Cell Differentiation / genetics. Cell Line, Tumor. Gene Expression Profiling. HT29 Cells. Humans. Intestinal Neoplasms / chemistry. Intestinal Neoplasms / genetics. Intestinal Neoplasms / pathology. Medulloblastoma / chemistry. Medulloblastoma / genetics. Medulloblastoma / pathology. Neoplasm Proteins / analysis. Neoplasm Proteins / biosynthesis. Neoplasm Proteins / genetics. Peptides / analysis. Peptides / genetics

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  • (PMID = 17407598.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Peptides; 0 / Proteins
  • [Other-IDs] NLM/ PMC1852558
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19. Fraquelli M, Sciola V, Villa C, Conte D: The role of ultrasonography in patients with celiac disease. World J Gastroenterol; 2006 Feb 21;12(7):1001-4
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  • The aim of the present review was to summarize the current evidence on the role of ultrasonography (US) and doppler-US in the diagnosis of celiac disease.
  • Firstly, case control studies identified some of these US signs and then in a prospective series some of these parameters, due to their high specificity, have been shown to be of value in confirming CD diagnosis, whereas others, due to their high sensitivity, have been demonstrated to be useful in excluding the presence of the disease.
  • The last part of this review will deal with the possible role of US in identifying the most severe and common intestinal complication of CD, i.e. the enteropathy-associated T cell non-Hodgkin lymphoma.
  • [MeSH-minor] Abdomen / blood supply. Abdomen / ultrasonography. Adenocarcinoma / diagnosis. Adenocarcinoma / ultrasonography. Algorithms. Case-Control Studies. Humans. Intestinal Neoplasms / ultrasonography. Intestine, Small / ultrasonography. Lymphoma, Non-Hodgkin / ultrasonography. Prospective Studies. Splanchnic Circulation. Ultrasonography. Ultrasonography, Doppler / methods

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  • (PMID = 16534837.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC4087888
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20. Tankova L, Berberova M, Damianov N, Tsankov Ts, Kovatchki D: Preoperative diagnosis of jejunal adenocarcinoma--a case report. J BUON; 2008 Jan-Mar;13(1):123-6
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  • [Title] Preoperative diagnosis of jejunal adenocarcinoma--a case report.
  • We report herein the case of a preoperatively diagnosed small bowel adenocarcinoma.
  • An US-guided fine (20 gauge) needle aspiration (FNA) cytology of the mass was performed and showed moderately differentiated adenocarcinoma of intestinal origin.
  • On surgical exploration a jejunal tumor of high consistency was found, located 15 cm distantly from the Treitz ligament, infiltrating up to 2/3 of the bowel circumference and partly obstructing its lumen.
  • The histological evaluation of the resected material showed highly to moderately differentiated adenocarcinoma with 5 regional lymph node metastases.
  • The combination of US with Doppler and FNA established preoperatively the malignant small bowel disease.
  • [MeSH-major] Adenocarcinoma / diagnosis. Jejunal Neoplasms / diagnosis

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  • (PMID = 18404799.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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21. Liu WH, Zhou XG: [CD30-positive of diffuse large B-cell lymphoma of small intestine co-existing with tubular adenocarcinoma of rectum: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2007 Sep;36(9):641-2
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  • [Title] [CD30-positive of diffuse large B-cell lymphoma of small intestine co-existing with tubular adenocarcinoma of rectum: report of a case].
  • [MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Neoplasms, Multiple Primary / pathology. Rectal Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD30 / metabolism. Humans. Intestine, Small. Male

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  • (PMID = 18070460.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD30
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22. Tan KY, Moriya Y, Konishi F: Multimedia articles. Small-bowel tumors with extensive mesenteric involvement can be resected with careful dissection of the mesenteric vessels with good outcomes. Dis Colon Rectum; 2009 Jun;52(6):1184-5
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  • [Title] Multimedia articles. Small-bowel tumors with extensive mesenteric involvement can be resected with careful dissection of the mesenteric vessels with good outcomes.
  • We show the video of the dissection and resection of a locally advanced jejunal adenocarcinoma, with the involvement of multiple loops, to the base of the mesentery.
  • Complete resection was made possible by careful dissection of the jejunal vessels and superior mesenteric artery at the root of the small-bowel mesentery (see Video, Supplemental Digital Content 1, http://links.lww.com/A1308).
  • [MeSH-major] Adenocarcinoma / surgery. Intestinal Neoplasms / surgery. Intestine, Small. Mesentery / surgery

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  • (PMID = 19581866.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Crook DW, Knuesel PR, Froehlich JM, Eigenmann F, Unterweger M, Beer HJ, Kubik-Huch RA: Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel disease. Eur J Gastroenterol Hepatol; 2009 Jan;21(1):54-65
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  • [Title] Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel disease.
  • PURPOSE: The goal of this study was to compare magnetic resonance enterography (MRE) and video capsule endoscopy (VCE) in suspected small bowel disease.
  • MATERIALS AND METHODS: Nineteen patients with suspected small bowel disease participated in a prospective clinical comparison of MRE versus VCE.
  • RESULTS: Small bowel pathologies were found in 15 out of 19 patients: Crohn's disease (n= 5), lymphoma (n= 4), lymphangioma (n= 1), adenocarcinoma (n= 1), postradiation enteropathy (n= 1), NSAID-induced enteropathy (n =1), angiodysplasia (n= 1), and small bowel adhesions (n= 1).
  • MRE revealed 19 extraenteric findings in 11 patients as well as small bowel adhesions not detected on VCE (n= 1).
  • Thus, VCE and MRE appear to be complementary methods which, when used in conjunction, may better characterize suspected small bowel disease.
  • [MeSH-major] Capsule Endoscopy. Intestinal Diseases / diagnosis. Intestine, Small. Magnetic Resonance Imaging / methods

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  • (PMID = 19086147.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] England
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24. Pilleul F, Penigaud M, Milot L, Saurin JC, Chayvialle JA, Valette PJ: Possible small-bowel neoplasms: contrast-enhanced and water-enhanced multidetector CT enteroclysis. Radiology; 2006 Dec;241(3):796-801
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  • [Title] Possible small-bowel neoplasms: contrast-enhanced and water-enhanced multidetector CT enteroclysis.
  • PURPOSE: To prospectively evaluate the sensitivity and specificity of contrast material-enhanced and water-enhanced multidetector computed tomographic (CT) enteroclysis in depicting small-bowel neoplasms in symptomatic patients, with endoscopic, tissue, and follow-up findings as reference standards.
  • Two hundred nineteen patients (108 male, 111 female; age range, 17-98 years; mean, 53.1 years) with clinical suspicion of small-bowel neoplasm underwent contrast- and water-enhanced multidetector CT enteroclysis after normal findings of upper and lower gastrointestinal endoscopy.
  • The prospective interpretations of CT enteroclysis results include evaluation of focal bowel wall thickening, small-bowel masses, small-bowel stenosis, mesenteric stranding, enlarged mesenteric lymph nodes, and visceral metastasis.
  • The overall sensitivity and specificity in identifying patients with small-bowel lesions were 84.7% and 96.9%, respectively.
  • Findings of pathologic examination confirmed small-bowel tumor in 50 patients with carcinoid tumor (n = 19), adenocarcinoma (n = 7), lymphoma (n = 5), jejunal adenoma (n = 9), stromal tumor (n = 5), ectopic pancreas (n = 2), angiomatous mass (n = 2), or metastasis (n = 1).
  • CONCLUSION: Contrast- and water-enhanced multidetector CT enteroclysis had an overall accuracy of 84.7% for depiction of small-bowel neoplasms.
  • [MeSH-major] Intestinal Neoplasms / radiography. Intestine, Small. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Endoscopy, Gastrointestinal. Female. Humans. Iopamidol / analogs & derivatives. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Reference Standards. Sensitivity and Specificity

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  • [Copyright] (c) RSNA, 2006.
  • (PMID = 17053201.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 17E17JBP8L / iomeprol; JR13W81H44 / Iopamidol
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25. Ilha MR, Loretti AP, Barros CS, Gimeno EJ, Martin CA: Papillary adenocarcinoma of the extrahepatic bile duct in a Holstein cow. Vet Pathol; 2005 Jan;42(1):74-7
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  • [Title] Papillary adenocarcinoma of the extrahepatic bile duct in a Holstein cow.
  • At necropsy, the common bile duct was greatly enlarged, with thickened walls, and tightly adhered to the hepatic capsular surface and serosa of adjacent loops of the small intestine.
  • The diagnosis of papillary adenocarcinoma of the extrahepatic bile duct was based on the morphologic features of the neoplasm and evidence of local invasion.
  • [MeSH-major] Adenocarcinoma, Papillary / veterinary. Bile Duct Neoplasms / veterinary. Bile Ducts, Extrahepatic / pathology. Cattle Diseases / pathology

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  • (PMID = 15657275.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-7; 68238-35-7 / Keratins
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26. Hétet JF, Rigaud J, Müller B, Léauté F, Renaudin K, Bouchot O, Karam G: [Unusual metastatic spread after converted laparoscopic radical nephrectomy: natural history of the tumour or role of laparoscopy?]. Prog Urol; 2005 Sep;15(4):718-21
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  • [Transliterated title] Evolution métastatique inhabituelle apres néphrectomie elargie par lomboscopie convertie: histoire naturelle de la tumeur ou responsabilité de la coelioscopie?
  • The authors report a case of metastasis to unusual sites (sigmoid colon, small intestine, root of the nose) after converted retroperitoneal laparoscopic radical nephrectomy for a T3 renal tumour, which raises the problem of the possible role of the laparoscopic approach in this unusual metastatic progression of the disease.
  • [MeSH-major] Adenocarcinoma / secondary. Kidney Neoplasms / pathology. Laparoscopy / adverse effects. Neoplasm Seeding. Nephrectomy / methods

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  • (PMID = 16459693.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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27. Bulfoni A: [Primary adenocarcinoma of jejunum with obscure gastrointestinal bleeding]. Clin Ter; 2006 Sep-Oct;157(5):431-4
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  • [Title] [Primary adenocarcinoma of jejunum with obscure gastrointestinal bleeding].
  • [Transliterated title] Adenocarcinoma primitivo del digiuno ad esteriorizzazione con enterorragia.
  • A case of primary small bowel adenocarcinoma is reported because of the rarity of this malignancy.
  • [MeSH-major] Adenocarcinoma. Gastrointestinal Hemorrhage / etiology. Jejunal Neoplasms
  • [MeSH-minor] Capsule Endoscopy. Diagnosis, Differential. Female. Humans. Jejunum / pathology. Middle Aged. Occult Blood. Prognosis

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  • (PMID = 17147051.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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28. Su MC, Yuan RH, Lin CY, Jeng YM: Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system. Mod Pathol; 2008 Nov;21(11):1379-86
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  • [Title] Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system.
  • Cadherin-17, also called liver-intestine cadherin, is a calcium-dependent transmembrane glycoprotein that mediates cell-cell adhesion in intestinal epithelium.
  • Expression of cadherin-17 was reported in gastric, pancreatic, and colorectal adenocarcinomas but not in other tumors.
  • Whether cadherin-17 can be used as a marker for diagnosis of cancers is still unclear.
  • Among normal tissues, the expression of cadherin-17 was limited to epithelial cells of small intestine and colon.
  • Colorectal adenocarcinomas showed staining in 96% of cases and most of them had strong and diffuse staining.
  • Gastric, pancreatic, and biliary adenocarcinomas showed diffuse or scattered staining in about 25-50% of cases.
  • When a two-marker, Cadherin-17/cytokeratin 7, profile was used, 37 of 38 (97%) cadherin-17(+)/cytokeratin 7(-) tumors were colorectal adenocarcinomas; 49 of 56 (86%) cadherin-17(+)/cytokeratin 7(+) tumors were gastric, pancreatic, or biliary adenocarcinomas.
  • Our results show that cadherin-17 is a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Cadherins / analysis. Gastrointestinal Neoplasms / diagnosis
  • [MeSH-minor] Colorectal Neoplasms / chemistry. Colorectal Neoplasms / diagnosis. Female. Humans. Immunoenzyme Techniques. Male. Pancreatic Neoplasms / chemistry. Pancreatic Neoplasms / diagnosis. Stomach Neoplasms / chemistry. Stomach Neoplasms / diagnosis

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  • (PMID = 18552820.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDH17 protein, human; 0 / Cadherins
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29. Durno CA, Holter S, Sherman PM, Gallinger S: The gastrointestinal phenotype of germline biallelic mismatch repair gene mutations. Am J Gastroenterol; 2010 Nov;105(11):2449-56
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  • The aim of this study was to characterize patients with GI small bowel and/or colorectal cancers (CRCs) who have germline biallelic MMR mutations.
  • RESULTS: The database identified 237 patients with intestinal cancer diagnosed before the age of 35 years.
  • Among the 29 patients with CRCs, the mean age of first cancer diagnosis was 16.4 years (range: 5-28).
  • Six individuals with biallelic MMR gene mutations have been reported with small bowel adenocarcinoma (mean age 20 years (range: 11-41)).
  • CONCLUSIONS: Biallelic MMR mutations are an underrecognized cause of small bowel and colonic cancers in children and young adults.
  • [MeSH-major] Alleles. Colorectal Neoplasms / genetics. DNA Mismatch Repair. Genetic Predisposition to Disease. Germ-Line Mutation. Intestinal Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. DNA Mutational Analysis. Databases, Factual. Humans. Intestine, Small. Microsatellite Instability. Phenotype. Registries

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  • (PMID = 20531397.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Ruiz-Tovar J, Martínez-Molina E, Morales V, Sanjuanbenito A: [Primary small bowel adenocarcinoma]. Cir Esp; 2009 Jun;85(6):354-9
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  • [Title] [Primary small bowel adenocarcinoma].
  • [Transliterated title] Adenocarcinoma primario de intestino delgado.
  • INTRODUCTION: Primary small bowel adenocarcinoma is an uncommon tumour, with non-specific symptoms that cause a delay in the diagnosis and consequently a worse outcome for the patient.
  • MATERIAL AND METHOD: We performed a retrospective study of our experience with 17 patients diagnosed with primary small bowel adenocarcinoma, excluding all the cases suggesting secondary involvement of the small bowel from an adenocarcinoma in other locations.
  • Those with duodenal tumours underwent 4 pancreaticoduodenectomies, 3 gastroenterostomies and 1 diagnostic biopsy; 6 bowel resections with lymphadenectomy, 2 en-bloc resections and 1 by-pass were performed on those with jejuno-ileal tumours.
  • CONCLUSIONS: Curative treatment consists of small bowel resection.
  • [MeSH-major] Adenocarcinoma. Duodenal Neoplasms. Ileal Neoplasms. Jejunal Neoplasms

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  • (PMID = 19344893.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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31. Prodinger PM, Sarbia M, Massmann J, Straka C, Meyer G, Steinlein OK: Gorlin syndrome associated with small bowel carcinoma and mesenchymal proliferation of the gastrointestinal tract: case report and review of literature. BMC Cancer; 2010;10:360
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  • [Title] Gorlin syndrome associated with small bowel carcinoma and mesenchymal proliferation of the gastrointestinal tract: case report and review of literature.
  • BACKGROUND AND CASE PRESENTATION: A patient with nevoid basal cell carcinoma syndrome (Gorlin syndrome) presented with two unusual clinical features, i.e. adenocarcinoma of the small bowel and extensive mesenchymal proliferation of the lower gastrointestinal tract.
  • [MeSH-major] Basal Cell Nevus Syndrome / pathology. Cell Proliferation. Gastrointestinal Tract / pathology. Intestinal Neoplasms / pathology. Intestine, Small / pathology. Mesoderm / pathology

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  • (PMID = 20609239.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Cell Surface; 0 / patched receptors
  • [Other-IDs] NLM/ PMC2912266
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32. Lutz JC, El-Bouihi M, Vidal N, Fricain JC, Robert M, Deminière C, Zwetyenga N: Mandibular metastases from an ileum stromal tumor. Rev Stomatol Chir Maxillofac; 2008 Dec;109(6):399-402
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  • Jaw metastases from the gastrointestinal (GI) tract usually evolve from adenocarcinoma of the esophagus, colon, and rectum.
  • These tumors are thought to arise from Cajal cells in GI tract walls, essential for intestine motor function.
  • The small intestine harbors only 30% of GIST.
  • The patient was treated with imatinib but died 11 months after the diagnosis.
  • DISCUSSION: The prevalence of GIST is low but the true incidence may be higher because of under-diagnosis.
  • GIST should be included in the differential diagnosis of intramandibular tumor in patients with prior or current non-oral malignancy.

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  • (PMID = 19010506.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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33. Stratopoulos C, Papakonstantinou A, Anagnostopoulos G, Terzis I, Tzimas G, Gourgiotis S, Vamvouka C, Hadjiyannakis E: Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study. Eur J Cancer Care (Engl); 2009 Sep;18(5):466-9
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  • [Title] Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study.
  • However, the coexistence of neurofibromatosis with small-bowel adenocarcinoma is exceedingly rare.
  • We present an uncommon case of neurofibromatosis type 1, involving the small bowel in a 73-year-old man, who was admitted to our department with signs of acute abdomen.
  • These nodules obstructed ileal lumen, while the intestine wall was perforated in one point.
  • Histology revealed neurofibromatosis type 1 with malignant transformation to small-bowel adenocarcinoma.
  • We suggest that adenocarcinoma of small bowel should be considered in the evaluation of acute abdominal pain in neurofibromatosis patients.
  • [MeSH-major] Adenocarcinoma / pathology. Ileal Neoplasms / pathology. Intestine, Small / pathology. Neoplasms, Multiple Primary / pathology. Neurofibromatosis 1 / pathology
  • [MeSH-minor] Abdomen, Acute / etiology. Aged. Follow-Up Studies. Humans. Intestinal Obstruction / etiology. Intestinal Obstruction / pathology. Male. Tomography, X-Ray Computed

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  • (PMID = 19473375.001).
  • [ISSN] 1365-2354
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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34. Posey JA 3rd, Saif MW, Carlisle R, Goetz A, Rizzo J, Stevenson S, Rudoltz MS, Kwiatek J, Simmons P, Rowinsky EK, Takimoto CH, Tolcher AW: Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas. Clin Cancer Res; 2005 Nov 1;11(21):7866-71
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  • Unconfirmed partial responses were observed in two patients, one with metastatic small bowel adenocarcinoma and the other with metastatic esophageal cancer.

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  • (PMID = 16278410.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR00032
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 30IQX730WE / Polyethylene Glycols; 581079-18-7 / pegamotecan; XT3Z54Z28A / Camptothecin
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35. Chaiyasate K, Jain AK, Cheung LY, Jacobs MJ, Mittal VK: Prognostic factors in primary adenocarcinoma of the small intestine: 13-year single institution experience. World J Surg Oncol; 2008;6:12
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  • [Title] Prognostic factors in primary adenocarcinoma of the small intestine: 13-year single institution experience.
  • BACKGROUND: Adenocarcinoma of the small bowel is a relatively rare malignancy as compared to the other malignancies of the gastrointestinal tract.
  • Nonspecific presentation and infrequent occurrence often leads to a delay in diagnosis and consequent poor prognosis.
  • METHODS: The medical records of a total of 27 patients treated for adenocarcinoma of the small bowel at Providence Hospital and Medical Centers from year 1990 through 2003 were reviewed retrospectively.
  • RESULTS: The patients included nine males and eighteen females with a median age at diagnosis of 62 years.
  • Only 48% of the patients had an accurate preoperative diagnosis while another 33% had a diagnosis suspicious of small bowel malignancy.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Intestinal Neoplasms / mortality. Intestinal Neoplasms / surgery. Intestine, Small / pathology

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  • (PMID = 18237404.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2253527
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36. Ausloos F, Scagnol I, Belaiche J: [Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report]. Rev Med Liege; 2009 Jul-Aug;64(7-8):394-7
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  • [Title] [Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report].
  • [Transliterated title] Adénocarcinome de l'intestin grêle compliquant une maladie coeliaque de l'adulte: à propos d'un cas.
  • This small bowel adenocarcinoma is rare and concerns less than 5% of the digestive neoplasias.
  • We are reporting the case of a 67-years-old woman whose coeliac disease has been complicated 5 years thereafter by a jejunal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Celiac Disease / complications. Incidental Findings. Jejunal Neoplasms / complications. Jejunal Neoplasms / diagnosis

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  • (PMID = 19777919.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
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37. Kaukinen K, Peräaho M, Lindfors K, Partanen J, Woolley N, Pikkarainen P, Karvonen AL, Laasanen T, Sievänen H, Mäki M, Collin P: Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease. Aliment Pharmacol Ther; 2007 May 15;25(10):1237-45
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  • [Title] Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease.
  • Small intestinal biopsy and bone mineral density were investigated in 2001 and clinical features were followed up until 2005.
  • RESULTS: Thirteen coeliac patients had persistent small intestinal villous atrophy despite maintaining gluten-free diet.
  • In 2005, two of the non-responders had developed symptomatic refractory sprue, one died of lymphoma and one of carcinoid tumour, and one gastric adenocarcinoma was operated.
  • [MeSH-major] Celiac Disease / diet therapy. Intestine, Small / pathology. Lymphoma / etiology
  • [MeSH-minor] Adult. Aged. Atrophy. Female. Humans. Intestinal Mucosa / pathology. Middle Aged. Patient Care

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  • (PMID = 17451570.001).
  • [ISSN] 0269-2813
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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38. Losowsky MS: A history of coeliac disease. Dig Dis; 2008;26(2):112-20
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  • Coeliac disease may have an ancient history dating back to the 1st and 2nd centuries AD.
  • Dicke's colleagues, Weijers and Van de Kamer, showed that measurement of stool fat reflected the clinical condition.
  • Histological abnormalities of the lining of the small intestine were demonstrated beyond doubt by Paulley in 1954 and techniques of per-oral biopsy described by Royer in 1955 and Shiner in 1956 afforded reliable diagnosis.
  • Lymphoma, adenocarcinoma and ulceration of the small intestine and a range of immunological disorders are associated.
  • [MeSH-minor] Dermatitis Herpetiformis / etiology. Dermatitis Herpetiformis / history. History, 19th Century. History, 20th Century. History, Ancient. Humans. Intestinal Neoplasms / etiology. Intestinal Neoplasms / history. Intestine, Small / pathology. Lymphoma / etiology. Lymphoma / history. Transglutaminases / metabolism. Ulcer / etiology. Ulcer / history

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  • [Copyright] 2008 S. Karger AG, Basel.
  • (PMID = 18431060.001).
  • [ISSN] 1421-9875
  • [Journal-full-title] Digestive diseases (Basel, Switzerland)
  • [ISO-abbreviation] Dig Dis
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] EC 2.3.2.13 / Transglutaminases
  • [Number-of-references] 96
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39. Yamaga Y, Ohana M, Nakamura T, Kikuchi S, Matsumura K, Takita M, Iwamoto S, Morisawa T, Miyajima S, Kida H, Okano A, Okinaga S, Kusumi F, Takakuwa H, Honjou G: [A case of jejunal adenocarcinoma with serum DUPAN-2 elevation]. Nihon Shokakibyo Gakkai Zasshi; 2010 Nov;107(11):1806-13
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  • [Title] [A case of jejunal adenocarcinoma with serum DUPAN-2 elevation].
  • Ileus with ulcerated jejunal tumor was diagnosed and biopsy revealed adenocarcinoma.
  • Surgical resection was performed: both tumors were adenocarcinoma, but the ovarian tumor was considered to be metastatic clinically and histologically.
  • This case shows a possible relation between small bowel adenocarcinoma and DUPAN-2.
  • [MeSH-major] Adenocarcinoma / diagnosis. Antigens, Neoplasm / blood. Jejunal Neoplasms / diagnosis

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  • (PMID = 21071898.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DU-PAN-2 antigen, human
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40. Gay G, Delvaux M: Double balloon enteroscopy in Crohn's disease and related disorders: our experience. Gastrointest Endosc; 2007 Sep;66(3 Suppl):S82-90
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  • [MeSH-major] Crohn Disease / diagnosis. Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Intestinal Diseases / diagnosis. Intestinal Neoplasms / diagnosis. Intestine, Small
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Adult. Aged. Algorithms. Anti-Inflammatory Agents, Non-Steroidal / adverse effects. Biopsy. Capsule Endoscopy. Diagnosis, Differential. Equipment Design. Humans. Ileitis / chemically induced. Ileitis / diagnosis. Ileitis / therapy. Intestinal Mucosa / pathology. Jejunal Neoplasms / diagnosis. Jejunal Neoplasms / therapy. Linitis Plastica / diagnosis. Linitis Plastica / therapy. Male. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / therapy. Stomach Neoplasms / diagnosis. Stomach Neoplasms / therapy

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  • (PMID = 17709041.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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41. Gibson RJ, Bowen JM, Keefe DM: Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor-bearing DA rats. Int J Cancer; 2005 Sep 1;116(3):464-70
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  • We also determined the protective effects of single large and multiple small doses of palifermin.
  • Tumor-bearing DA rats were treated with a single large (10 mg/kg) dose of palifermin 3 days prior to, or multiple small (3 mg/kg day for 3 days) doses of palifermin or vehicle control prior to, receiving 2 doses of 150 mg/kg irinotecan.
  • Small and large intestinal weights were maintained.
  • Intestinal morphometry was not maintained in palifermin-pretreated rats despite being increased prior to irinotecan treatment.
  • Palifermin pretreatment did not prevent apoptosis that peaked at 6 hr in the jejunum or colon, but prevented apoptosis at 96 hr in the small intestine.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / veterinary. Animals. Female. Fibroblast Growth Factor 7. Keratinocytes. Mammary Neoplasms, Animal / drug therapy. Rats. Survival Analysis

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  • (PMID = 15800945.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Fgf7 protein, rat; 126469-10-1 / Fibroblast Growth Factor 7; 62031-54-3 / Fibroblast Growth Factors; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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42. Lo YL, Ho CT, Tsai FL: Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin. Eur J Pharm Sci; 2008 Sep 2;35(1-2):52-67
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  • We evaluated the effects and mechanisms of glycocholic acid (GC), a bile acid, on inhibiting pump and non-pump resistance, and increasing the chemosensitivity of epirubicin in human colon adenocarcinoma Caco-2 cells and rat intestine.
  • GC increased the cytotoxicity of epirubicin, significantly increased the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis.
  • GC and epirubicin significantly reduced mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulated the MDR1 promoter region; suppressed the mRNA expression of Bcl-2; induced the mRNA expression of Bax; and significantly increased the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3.

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  • (PMID = 18606222.001).
  • [ISSN] 0928-0987
  • [Journal-full-title] European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • [ISO-abbreviation] Eur J Pharm Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Chromatin; 0 / DNA, Neoplasm; 0 / P-Glycoproteins; 3Z8479ZZ5X / Epirubicin; EC 1.13.12.- / Luciferases; G59NX3I3RT / Glycocholic Acid
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43. Choquet P, Calon A, Breton E, Beck F, Domon-Dell C, Freund JN, Constantinesco A: Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice. C R Biol; 2007 Nov;330(11):821-7
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  • In vivo imaging could greatly facilitate these trials, but the small size of the animals is a major limitation for the direct visualization of intestinal tissue.
  • Here we report a method of in vivo imaging of the mouse intestine based on X-ray micro-computed tomography using multiple contrast agents.
  • This method was validated in the model of non-cancerous polyp-like heteroplasia that spontaneously develops in the caecum area of Cdx2+/- mutant mice and in the model of colon adenocarcinoma induced by administration of the chemical carcinogen azoxymethane.
  • As a simple and non-invasive method, multiple-contrast X-ray micro-computed tomography is appropriate for pre-clinical studies of intestinal diseases in living mice.
  • [MeSH-minor] Animals. Equipment Design. Heterozygote. Homeodomain Proteins / genetics. Intestinal Diseases / radiography. Male. Mice. Mice, Knockout. Transcription Factors / deficiency. Transcription Factors / genetics

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  • (PMID = 17923376.001).
  • [ISSN] 1631-0691
  • [Journal-full-title] Comptes rendus biologies
  • [ISO-abbreviation] C. R. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Cdx2 protein, mouse; 0 / Homeodomain Proteins; 0 / Transcription Factors
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44. Sugae T, Yaguchi T, Kajikawa M, Nakayama S, Takase T, Inokawa Y, Tsushima Y, Watanabe T, Harada A: [A case report of primary adenocarcinoma of small intestine successfully treated with FOLFOX]. Gan To Kagaku Ryoho; 2008 Nov;35(11):1969-71
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  • [Title] [A case report of primary adenocarcinoma of small intestine successfully treated with FOLFOX].
  • This is an account of a case of primary adenocarcinoma of the small intestine successfully treated with chemotherapy.
  • Abdominal computerized tomography revealed bowel obstruction, and this was found at surgery to be due to a tumor at the jejunum 100 cm distal from the Treitz ligament.
  • Pathological diagnosis of the resected specimen was adenocarcinoma.
  • Primary small intestinal adenocarcinoma is a rare disease with a dismal prognosis.
  • The current patient survived for 4 years and 5 months after the diagnosis, owing at least partially to the mFOLFOX6 which was found to be the only active regimen.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestinal Neoplasms / pathology. Intestine, Small / drug effects

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  • (PMID = 19011354.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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45. Zhang MQ, Chen ZM, Wang HL: Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma. Mod Pathol; 2006 Apr;19(4):573-80
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  • [Title] Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma.
  • Small intestinal adenocarcinoma is an uncommon neoplasm morphologically similar to or indistinguishable from colorectal adenocarcinoma.
  • Although much has been learned about genetic pathways critical to colorectal tumorigenesis, little is known about molecular alterations involved in the development of small intestinal adenocarcinoma.
  • In this study, we immunohistochemically compared non-ampullary small intestinal adenocarcinomas with sporadic colorectal adenocarcinomas for the expression of several proteins known to serve pivotal roles in colorectal tumorigenesis.
  • The results show that complete loss of adenomatous polyposis coli immunoreactivity, presumably resulting from its gene mutations, was observed in eight of 26 (31%) small intestinal adenocarcinomas and 36 of 51 (71%) colorectal adenocarcinomas (P = 0.0008).
  • Nuclear localization of beta-catenin, an indirect evidence of deregulated Wnt signaling pathway, was observed in 5 (19%) small intestinal adenocarcinomas and 36 (71%) colorectal adenocarcinomas (P<0.0001).
  • Total lack of nuclear staining for one or more of the DNA mismatch repair enzymes occurred in a similar low frequency in both small intestinal and colorectal adenocarcinomas, seen in two of 25 (8%) and 10 of 47 (21%) cases, respectively (P = 0.1958).
  • The frequencies of aberrant p53 and RB expression were also similar between small intestinal and colorectal adenocarcinomas.
  • These observations indicate that defects in the Wnt and microsatellite instability pathways occur in over 90% of colorectal adenocarcinomas, but in only 40% of small intestinal adenocarcinomas.
  • Small intestinal tumorigenesis appears to follow a distinct, yet unidentified, molecular pathway(s) from its colorectal counterpart despite their morphologic similarity.
  • [MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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  • (PMID = 16501564.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Retinoblastoma Protein; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
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46. Verma D, Stroehlein JR: Adenocarcinoma of the small bowel: a 60-yr perspective derived from M. D. Anderson Cancer Center Tumor Registry. Am J Gastroenterol; 2006 Jul;101(7):1647-54
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  • [Title] Adenocarcinoma of the small bowel: a 60-yr perspective derived from M. D. Anderson Cancer Center Tumor Registry.
  • OBJECTIVES: To analyze subsite distribution of small bowel adenocarcinoma (SBA) over a 60-yr interval and to determine the impact of age, gender, and ethnicity on SBA cross-referenced for selected variables including anatomic distribution.
  • METHODS: Data from 1944 to 2003 were extracted from the M. D.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Intestinal Neoplasms / epidemiology. Intestinal Neoplasms / pathology. Intestine, Small

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  • (PMID = 16863573.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Hong SH, Koh YH, Rho SY, Byun JH, Oh ST, Im KW, Kim EK, Chang SK: Primary adenocarcinoma of the small intestine: presentation, prognostic factors and clinical outcome. Jpn J Clin Oncol; 2009 Jan;39(1):54-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenocarcinoma of the small intestine: presentation, prognostic factors and clinical outcome.
  • BACKGROUND: Malignant small intestine tumor accounts for 0.1-0.3% of all malignancies.
  • Although primary adenocarcinoma is the most common histologic subtype, there is no report of the clinical characteristics and natural history in the Asian population.
  • METHODS: We conducted retrospective analysis for the patients with the small intestine adenocarcinoma to explore the clinical characteristics and prognosis.
  • All patients with adenocarcinoma of small intestine diagnosed between March 1997 and March 2007 in the Catholic Medical Center in Korea were identified through the cancer registry.
  • CONCLUSIONS: The prognosis of primary adenocarcinoma of small intestine was poor, especially in cases where curative resection could not to be performed.
  • [MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Female. Humans. Korea. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 18997182.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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48. Fishman PN, Pond GR, Moore MJ, Oza A, Burkes RL, Siu LL, Feld R, Gallinger S, Greig P, Knox JJ: Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases. Am J Clin Oncol; 2006 Jun;29(3):225-31
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  • [Title] Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases.
  • BACKGROUND: Small bowel adenocarcinoma is a rare cancer that has generally been considered resistant to chemotherapy, although little has been published on the role of chemotherapy.
  • A retrospective analysis was conducted of patients with advanced small bowel adenocarcinoma to explore chemotherapy use, and gain knowledge for ongoing management and future clinical trials.
  • PATIENTS AND METHODS: All patients with advanced adenocarcinoma of the small bowel treated at Princess Margaret Hospital (PMH) between 1986 and 2004 were identified through the cancer registry.
  • CONCLUSION: Chemotherapy appears to have activity in adenocarcinoma of the small bowel.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestinal Neoplasms / pathology

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  • (PMID = 16755174.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Bilici A, Karadag B, Doventas A, Seker M: Gastric pneumatosis intestinalis associated with malignancy: an unusual case report. World J Gastroenterol; 2009 Feb 14;15(6):758-60
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  • The most common localization is the small intestine.
  • We report on a 94-year-old man with gastric PI associated with inoperable adenocarcinoma localized in the duodenum.
  • We suggest that in patients presenting with PI, malignancy should be considered in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Duodenal Neoplasms / diagnosis. Pneumatosis Cystoides Intestinalis / diagnosis. Pneumatosis Cystoides Intestinalis / radiography
  • [MeSH-minor] Aged, 80 and over. Blood Proteins / analysis. Blood Proteins / isolation & purification. Diagnosis, Differential. Fatal Outcome. Humans. Male. Stomach Diseases / diagnosis. Stomach Diseases / etiology. Stomach Diseases / radiography. Tomography, X-Ray Computed. Urine / cytology

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  • (PMID = 19222105.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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50. Gayoso MJ, Muñoz R, Arias Y, Villar R, Rojo MA, Jiménez P, Ferreras JM, Aranguez I, Girbés T: Specific dose-dependent damage of Lieberkühn crypts promoted by large doses of type 2 ribosome-inactivating protein nigrin b intravenous injection to mice. Toxicol Appl Pharmacol; 2005 Sep 1;207(2):138-46
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  • As a consequence of the injury, the villi and crypt structures of the small intestine disappeared, leading to profuse bleeding and death.
  • In both cases, lethal and sub-lethal doses, the target of nigrin b appeared to be the highly proliferating stem cells of the intestinal crypts, which had undergone apoptotic changes.
  • Nigrin b killed COLO 320 human colon adenocarcinoma cells with an IC(50) of 3.1 x 10(-8) M and the effect was parallel to the extent of DNA fragmentation of these cells.
  • Accordingly, despite the low general toxicity exerted by nigrin b as compared with ricin, intravenous injection of large amounts of nigrin b is able to kill mouse intestinal stem cells without threatening the lives of the animals, thereby opening a door for its use for the targeting of intestinal stem cells.
  • [MeSH-major] Intestine, Small / drug effects. N-Glycosyl Hydrolases / toxicity. Plant Proteins / toxicity

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  • (PMID = 16102565.001).
  • [ISSN] 0041-008X
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Proteins; 0 / Ribosome Inactivating Proteins, Type 2; 9009-86-3 / Ricin; EC 3.2.2.- / N-Glycosyl Hydrolases
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51. Kalogerinis PT, Poulos JE, Morfesis A, Daniels A, Georgakila S, Daignualt T, Georgakilas AG: Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective. BMC Gastroenterol; 2010;10:109
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  • BACKGROUND: There is very small occurrence of adenocarcinoma in the small bowel.
  • We present a case of primary duodenal adenocarcinoma and discuss the findings of the case diagnostic modalities, current knowledge on the molecular biology behind small bowel neoplasms and treatment options.
  • CASE: The patient had a history of iron deficiency anemia and occult bleeding with extensive workup consisting of upper endoscopy, colonoscopy, capsule endoscopy, upper gastrointestinal series with small bowel follow through and push enteroscopy.
  • Due to persistent abdominal pain and iron deficiency anemia the patient underwent push enteroscopy which revealed adenocarcinoma of the duodenum.
  • The patient underwent en-bloc duodenectomy which revealed T3N1M0 adenocarcinoma of the 4th portion of the duodenum.
  • CONCLUSIONS: Primary duodenal carcinoma, although rare should be considered in the differential diagnosis of occult gastrointestinal bleeding when evaluation of the lower and upper GI tract is unremarkable.
  • We discuss the current evaluation and management of this small bowel neoplasm.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Duodenal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Duodenoscopy. Female. Humans. Laparotomy. Ligaments. Tomography, X-Ray Computed

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  • (PMID = 20849628.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2949773
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52. Ashman JB, Zelefsky MJ, Hunt MS, Leibel SA, Fuks Z: Whole pelvic radiotherapy for prostate cancer using 3D conformal and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys; 2005 Nov 1;63(3):765-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS AND MATERIALS: Between December 1996 and January 2002, 27 patients with prostate adenocarcinoma were treated with conformal WPRT as part of their definitive treatment.
  • Dose-volume histograms for the bowel, bladder, and rectum were compared for the three techniques.
  • RESULTS: Three-dimensional-CRT resulted in a 40% relative reduction (p < 0.001) in the volume of bowel receiving 45 Gy compared with 2D, and IMRT provided a further 60% reduction relative to 3D-CRT (p < 0.001).
  • CONCLUSIONS: Compared to conventional 2D planning, conformal planning for WPRT resulted in significant reductions in the doses delivered to the bowel, rectum, and bladder.
  • IMRT was superior to 3D-CRT in limiting the volume of bowel and rectum within high-dose regions.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colon / radiation effects. Diarrhea / etiology. Humans. Intestine, Small / radiation effects. Male. Middle Aged. Pelvis. Radiation Dosage. Radiotherapy, Intensity-Modulated / adverse effects. Radiotherapy, Intensity-Modulated / methods. Rectum / radiation effects. Urinary Bladder / radiation effects. Urination Disorders / etiology


53. Aurello P, Dente M, D'Angelo F, Nigri G, Cescon M, Ramacciato G: Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient. Am Surg; 2009 Feb;75(2):189-90
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  • [Title] Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient.
  • [MeSH-major] Adenocarcinoma / pathology. Crohn Disease / etiology. Ileal Neoplasms / pathology. Intestinal Obstruction / etiology


54. Malmberg EK, Pelaseyed T, Petersson AC, Seidler UE, De Jonge H, Riordan JR, Hansson GC: The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine. Biochem J; 2008 Mar 1;410(2):283-9
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  • [Title] The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine.
  • This suggests that Pdzk1 plays a specific role in stabilizing Muc3(17)in the apical membrane of small intestinal enterocytes.
  • [MeSH-major] Carrier Proteins / chemistry. Carrier Proteins / metabolism. Cell Membrane / metabolism. Intestinal Mucosa / metabolism. Mucins / chemistry. Mucins / metabolism
  • [MeSH-minor] Adenocarcinoma. Animals. Base Sequence. Binding Sites. Cell Line. Cell Line, Tumor. Cloning, Molecular. Colonic Neoplasms. Cricetinae. Cytoplasm / metabolism. DNA Primers. Humans. Intestine, Small / metabolism. Kidney. Mesocricetus. Microvilli / metabolism. Molecular Sequence Data. Recombinant Proteins / chemistry. Recombinant Proteins / metabolism


55. Delaunoit T, Neczyporenko F, Limburg PJ, Erlichman C: Pathogenesis and risk factors of small bowel adenocarcinoma: a colorectal cancer sibling? Am J Gastroenterol; 2005 Mar;100(3):703-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathogenesis and risk factors of small bowel adenocarcinoma: a colorectal cancer sibling?
  • Small bowel adenocarcinoma (SBA) is a very rare entity accounting for one-fourth of the small intestine neoplasms.
  • It appears that SBA shares several genetic characteristics with large bowel tumors, but also has unique features.
  • [MeSH-major] Adenocarcinoma / etiology. Intestinal Neoplasms / etiology. Intestine, Small

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  • (PMID = 15743371.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 101
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56. Piton G, Cosnes J, Monnet E, Beaugerie L, Seksik P, Savoye G, Cadiot G, Flourie B, Capelle P, Marteau P, Lemann M, Colombel JF, Khouri E, Bonaz B, Carbonnel F: Risk factors associated with small bowel adenocarcinoma in Crohn's disease: a case-control study. Am J Gastroenterol; 2008 Jul;103(7):1730-6
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  • [Title] Risk factors associated with small bowel adenocarcinoma in Crohn's disease: a case-control study.
  • BACKGROUND AND AIMS: It is well established that Crohn's disease (CD) is associated with an increased risk of small bowel adenocarcinoma (SBA).
  • METHODS: In 11 French centers affiliated with the GETAID (Groupe d'Etude Thérapeutique des Affections Inflammatoires du Tube Digestif), we identified 29 patients with CD and SBA.
  • RESULTS: In univariate analysis, the cases had had significantly less small bowel resection and received prolonged treatment with salicylates (more than 2 yr), less often than the controls (odds ratio, OR [95% confidence interval, CI] 0.07 [0.01-0.32] and 0.29 [0.10-0.82], respectively).
  • CONCLUSION: This study suggests that small bowel resection and prolonged salicylates use may protect against SBA in CD patients.
  • [MeSH-major] Adenocarcinoma / etiology. Crohn Disease / complications. Intestinal Neoplasms / etiology. Intestine, Small

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  • [CommentIn] Inflamm Bowel Dis. 2009 Sep;15(9):1434-5 [19202570.001]
  • (PMID = 18564124.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Salicylates
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57. Chang HK, Yu E, Kim J, Bae YK, Jang KT, Jung ES, Yoon GS, Kim JM, Oh YH, Bae HI, Kim GI, Jung SJ, Gu MJ, Kim JY, Jang KY, Jun SY, Eom DW, Kwon KW, Kang GH, Park JB, Hong S, Lee JS, Park JY, Hong SM, Korean Small Intestinal Cancer Study Group: Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases. Hum Pathol; 2010 Aug;41(8):1087-96
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  • [Title] Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases.
  • Small intestinal adenocarcinoma is a rare malignant neoplasm, and its clinicopathologic characteristics have not been well elucidated.
  • A total of 197 small intestinal adenocarcinoma cases were collected from 22 institutions in South Korea and were evaluated for clinicopathologic factors that affect the prognosis of small intestinal adenocarcinoma patients using univariate and multivariate analyses.
  • The median survival time for all small intestinal adenocarcinoma patients was 39.7 months.
  • Compared with small intestinal adenocarcinomas without accompanying sporadic adenomas, small intestinal adenocarcinomas with accompanying adenomas were more well differentiated (P < .0001), with a more polypoid growth pattern (P < .0001), a lower pT classification (P < .0001), less perineural invasion (P = .01), and less lymphatic invasion (P = .03).
  • Small intestinal adenocarcinoma patients with associated sporadic adenomas (77%) had a significantly better 5-year survival rate than those without sporadic adenomas (38%, P = .02).
  • By univariate analysis, small intestinal adenocarcinoma patients had significantly different survival based on pT classification (P = .003), lymph node metastasis (P < .0001), distal location (jejunal and ileal carcinomas) (P = .003), retroperitoneal tumor seeding (P < .0001), vascular invasion (P = .007), lymphatic invasion (P = .001), peritumoral dysplasia (P = .004), and radiation therapy (P = .006).
  • In conclusion, (1) small intestinal adenocarcinomas are diagnosed at an advanced disease stage; therefore, the development of strategies for detection at an earlier stage is needed. (2) Small intestinal adenocarcinoma patients with an adenomatous component had a better survival than those without an adenomatous component. (3) Lymph node metastasis and distal location (jejunum and ileum) of tumor are the most important independent prognostic factors.
  • [MeSH-major] Adenocarcinoma / pathology. Duodenal Neoplasms / pathology. Ileal Neoplasms / pathology. Jejunal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intestine, Small / pathology. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Prognosis

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20334897.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Gockel I, Hansen T, Junginger T: Image of the month. Gastric juvenile polyposis (GJP) in germline SMAD4 mutation accompanied by gastric cancer. Arch Surg; 2008 Mar;143(3):311-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / genetics. Polyps / genetics. Smad4 Protein / genetics. Stomach Neoplasms / genetics
  • [MeSH-minor] Adult. Anastomosis, Roux-en-Y. Endoscopy, Gastrointestinal. Esophagus / surgery. Female. Gastrectomy. Germ-Line Mutation. Humans. Intestine, Small / surgery. Lymph Node Excision

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  • (PMID = 18347281.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SMAD4 protein, human; 0 / Smad4 Protein
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59. Schottenfeld D, Beebe-Dimmer JL, Vigneau FD: The epidemiology and pathogenesis of neoplasia in the small intestine. Ann Epidemiol; 2009 Jan;19(1):58-69
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  • [Title] The epidemiology and pathogenesis of neoplasia in the small intestine.
  • PURPOSE: The mucosa of the small intestine encompasses about 90% of the luminal surface area of the digestive system, but only 2% of the total annual gastrointestinal cancer incidence in the United States.
  • METHODS: The remarkable contrast in age-standardized cancer incidence between the small and large intestine has been reviewed with respect to the cell type patterns, demographic features, and molecular characteristics of neoplasms.
  • RESULTS: Particularly noteworthy is the predominance of adenocarcinoma in the colon, which exceeds 98% of the total incidence by cell type, in contrast to that of 30% to 40% in the small intestine, resulting in an age-standardized ratio of rates exceeding 50-fold.
  • The positive correlation in global incidence rates of small and large intestinal neoplasms and the reciprocal increases in risk of second primary adenocarcinomas suggest that there are common environmental risk factors.
  • The pathophysiology of Crohn inflammatory bowel disease and the elevated risk of adenocarcinoma demonstrate the significance of the impaired integrity of the mucosal barrier and of aberrant immune responses to luminal indigenous and potentially pathogenic microorganisms.
  • CONCLUSION: In advancing a putative mechanism for the contrasting mucosal susceptibilities of the small and large intestine, substantial differences are underscored in the diverse taxonomy, concentration and metabolic activity of anaerobic organisms, rate of intestinal transit, changing pH, and the enterohepatic recycling and metabolism of bile acids.

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  • (PMID = 19064190.001).
  • [ISSN] 1873-2585
  • [Journal-full-title] Annals of epidemiology
  • [ISO-abbreviation] Ann Epidemiol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / K07 CA127214; United States / NCI NIH HHS / CA / N01PC35145; United States / NCI NIH HHS / CA / 1K07CA127214-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines
  • [Number-of-references] 151
  • [Other-IDs] NLM/ NIHMS521424; NLM/ PMC3792582
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60. Sheikh SS, Al-Khatti AA, Amr SS: Metachronus malignant rhabdoid tumor of the ileum and adenocarcinoma of lung: a unique case report. Ann Diagn Pathol; 2008 Feb;12(1):57-61
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  • [Title] Metachronus malignant rhabdoid tumor of the ileum and adenocarcinoma of lung: a unique case report.
  • Carcinomas of small intestine are quite uncommon neoplasms, and those with rhabdoid differentiation are exceedingly rare.
  • These poorly differentiated tumors pose a great deal of difficulty in diagnosis as well as in deciding whether they are primary or metastatic in origin because malignant rhabdoid tumors or carcinomas with rhabdoid differentiation of other sites can metastasize to the small intestine.
  • They behave more aggressively than the typical adenocarcinomas of the same location.
  • Herein, we report a 52-year-old patient with primary small bowel malignant rhabdoid tumor, who was completely disease-free after the initial presentation and management.
  • Five years later, he was found to have a lung mass proved to be adenocarcinoma, exhibiting focal giant cell differentiation without rhabdoid features.
  • [MeSH-major] Adenocarcinoma / pathology. Ileal Neoplasms / pathology. Lung Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Rhabdoid Tumor / pathology

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  • (PMID = 18164418.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Olschwang S, Bonaïti-Pellié C, Feingold J, Frébourg T, Grandjouan S, Lasset C, Laurent-Puig P, Lecuru F, Millat B, Sobol H, Thomas G, Eisinger F: [Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer), hereditary predisposition to colorectal and endometrial adenocarcinomas]. Pathol Biol (Paris); 2006 May;54(4):215-29
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  • [Title] [Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer), hereditary predisposition to colorectal and endometrial adenocarcinomas].
  • [Transliterated title] Identification et prise en charge du syndrome HNPCC (hereditary non polyposis colon cancer). Prédisposition héréditaire aux cancers du côlon, du rectum et de l'utérus.
  • Patients affected by the disease are at high risk for colorectal and endometrial carcinomas, but also for small intestine, urothelial, ovary, stomach and biliary tract carcinomas.
  • [MeSH-major] Adenocarcinoma / genetics. Colonic Neoplasms / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Endometrial Neoplasms / genetics. Rectal Neoplasms / genetics


62. Shi Z, Dragin N, Miller ML, Stringer KF, Johansson E, Chen J, Uno S, Gonzalez FJ, Rubio CA, Nebert DW: Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype. Int J Cancer; 2010 Nov 15;127(10):2334-50
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  • Tissues from 16 different organs-including proximal small intestine (PSI), liver and preputial gland duct (PGD)-were evaluated; microarray cDNA expression and >30 mRNA levels were measured.
  • Cyp1a1(-/-) mice revealed markedly increased CYP1B1 mRNA levels in the PSI, and between 8 and 12 weeks developed unique PSI adenomas and adenocarcinomas.
  • PSI adenocarcinomas exhibited striking upregulation of the Xist gene, suggesting epigenetic silencing of specific genes on the Y-chromosome; the Rab30 oncogene was upregulated; the Nr0b2 tumor suppressor gene was downregulated; paradoxical overexpression of numerous immunoglobulin kappa- and heavy-chain variable genes was found-although the adenocarcinoma showed no immunohistochemical evidence of being lymphatic in origin.

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  • (PMID = 20127859.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES006096-149007; United States / NIEHS NIH HHS / ES / P30 ES006096-139007; United States / NIEHS NIH HHS / ES / ES006096-119007; United States / NIEHS NIH HHS / ES / ES014403-03; United States / NIEHS NIH HHS / ES / R01 ES014403-02; United States / NIEHS NIH HHS / ES / ES006096-159007; United States / NIEHS NIH HHS / ES / ES014403-02; United States / NIEHS NIH HHS / ES / ES006096-149007; United States / NIEHS NIH HHS / ES / R01 ES014403; United States / NIEHS NIH HHS / ES / R01 ES014403-04; United States / NIEHS NIH HHS / ES / P30 ES006096; United States / NIEHS NIH HHS / ES / R01 ES014403-03S1; United States / NIEHS NIH HHS / ES / ES014403-03S1; United States / NIEHS NIH HHS / ES / P30 ES006096-159007; United States / NIEHS NIH HHS / ES / ES006096-139007; United States / NIEHS NIH HHS / ES / ES006096-129007; United States / NIEHS NIH HHS / ES / R01 ES014403-03; United States / NIEHS NIH HHS / ES / P30 ES006096-119007; United States / NIEHS NIH HHS / ES / P30 ES006096-129007; United States / NIEHS NIH HHS / ES / P30 ES06096
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 3417WMA06D / Benzo(a)pyrene; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / Cyp1b1 protein, mouse; EC 1.14.14.1 / Cytochrome P-450 CYP1A1; EC 1.14.14.1 / Cytochrome P-450 CYP1B1
  • [Other-IDs] NLM/ NIHMS184552; NLM/ PMC2917638
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63. Kodaira C, Osawa S, Mochizuki C, Sato Y, Nishino M, Yamada T, Takayanagi Y, Takagaki K, Sugimoto K, Kanaoka S, Furuta T, Ikuma M: A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy. World J Gastroenterol; 2009 Apr 14;15(14):1774-8
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  • [Title] A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy.
  • Small bowel adenocarcinoma (SBA) in patients with Crohn's disease (CD) is quite rare, difficult to diagnose without surgery, and has a poor prognosis.
  • PET/CT detected an accumulation spot in the small bowel.
  • An endoscopic forceps biopsy specimen showed poorly differentiated adenocarcinoma.
  • There were some longitudinal ulcer scars near the tumor, and the chronic inflammation in the small bowel appeared to be associated with the cancer development.
  • Since early diagnosis is extremely difficult in these cases, novel techniques, such as PET/CT and DBE, may be expected to help in making a preoperative diagnosis of the development of SBA in CD.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / etiology. Crohn Disease / complications. Endoscopy, Gastrointestinal / methods. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / etiology. Intestine, Small / pathology

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  • (PMID = 19360924.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2668786
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64. Simmen FA, Frank JA, Wu X, Xiao R, Hennings LJ, Prior RL: Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon. BMC Gastroenterol; 2009 Sep 16;9:67
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  • [Title] Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon.
  • METHODS: We examined efficacy of BB in inhibition of azoxymethane (AOM)-induced colon ACF and intestine tumors in male and female Sprague-Dawley rats (outbred strain).
  • There was a tendency (0.1 > P > 0.05) for fewer adenocarcinomas (relative to total of adenomatous polyps plus adenocarcinomas) in colons of female than male tumor-bearing rats; in small intestine, this gender difference was significant (P < 0.05).
  • BB favored (P < 0.05) fewer adenocarcinomas and more adenomatous polyps (as a proportion of total tumor number) in female rat small intestine.
  • Data indicate the potential for slowing tumor progression (adenomatous polyp to adenocarcinoma) by BB.

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  • (PMID = 19758446.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CB / N02-CB-07008
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / C-Peptide; MO0N1J0SEN / Azoxymethane
  • [Other-IDs] NLM/ PMC2752457
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65. Yamada K, Ikehara Y, Nakanishi H, Kozawa E, Tatematsu M, Sugiura H: Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma. J Orthop Sci; 2007 Nov;12(6):606-10
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  • [Title] Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma.
  • [MeSH-major] Acetabulum. Adenocarcinoma / secondary. Bone Neoplasms / secondary. Jejunal Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed

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  • (PMID = 18040646.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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66. Saindane AM, Losada M, Macari M: Focal amyloidoma of the small bowel mimicking adenocarcinoma on CT. AJR Am J Roentgenol; 2005 Nov;185(5):1187-9
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  • [Title] Focal amyloidoma of the small bowel mimicking adenocarcinoma on CT.
  • [MeSH-major] Amyloidosis / radiography. Intestinal Diseases / radiography. Intestine, Small. Tomography, X-Ray Computed
  • [MeSH-minor] Adenocarcinoma / radiography. Aged. Contrast Media. Diagnosis, Differential. Humans. Intestinal Neoplasms / radiography. Male

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  • (PMID = 16247131.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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67. Schäfer C, Rothfuss K, Kreichgauer HP, Stange EF: Efficacy of double-balloon enteroscopy in the evaluation and treatment of bleeding and non-bleeding small bowel disease. Z Gastroenterol; 2007 Mar;45(3):237-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy of double-balloon enteroscopy in the evaluation and treatment of bleeding and non-bleeding small bowel disease.
  • Double-balloon enteroscopy (DBE) is a newly developed method allowing deep insertion of a thin endoscope into the small bowel, thereby enabling inspection, biopsy and endoscopic treatment of previously inaccessible lesions.
  • A total of 109 DBEs were performed in 82 patients (57 patients with suspected small bowel blood loss and 25 patients with other indications).
  • The diagnostic success rate was 51 of 82 (62 %) with a higher rate in bleeders in whom angiodysplasias were the most frequent diagnosis.
  • In 4 patients, malignant neoplasias were newly diagnosed (2 gastrointestinal stroma tumors, 1 neuroendocrine tumor, 1 adenocarcinoma).
  • In conclusion, this series indicates that DBE of the small bowel - in concert with other diagnostic modalities - has a high diagnostic and therapeutic efficacy.
  • [MeSH-major] Catheterization / methods. Endoscopy, Gastrointestinal / methods. Gastrointestinal Hemorrhage / pathology. Gastrointestinal Hemorrhage / surgery. Intestinal Diseases / pathology. Intestinal Diseases / surgery. Intestine, Small / pathology. Intestine, Small / surgery

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  • (PMID = 17357953.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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68. Bergmann F, Singh S, Michel S, Kahlert C, Schirmacher P, Helmke B, Von Knebel Doeberitz M, Kloor M, Bläker H: Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway. Oncol Rep; 2010 Dec;24(6):1535-9
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  • [Title] Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway.
  • Celiac disease (CD) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma.
  • We hypothesized that CIM may link CD to small bowel carcinogenesis.
  • We determined microsatellite instability (MSI), CIM, and expression of MLH1 and MGMT in 3 CD-associated small bowel carcinomas and corresponding non-neoplastic mucosa.
  • The results were compared to those of small bowel mucosa from CD patients without carcinoma and 20 small bowel carcinomas from a non-CD origin.
  • In conclusion, our data reveal that the high-level CIM/MSI pathway is typical of CD-associated small bowel carcinomas and indicate that aberrant CpG island methylation links CD and carcinogenesis.
  • The data further suggest that CD should be considered in patients with small bowel adenocarcinoma, particularly when the tumors display MSI.
  • [MeSH-major] Adenocarcinoma / genetics. Celiac Disease / genetics. CpG Islands. DNA Methylation. Intestinal Neoplasms / genetics. Microsatellite Instability
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adult. Aged. Aged, 80 and over. Cohort Studies. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Humans. Intestinal Mucosa / metabolism. Intestinal Mucosa / pathology. Intestine, Small / metabolism. Intestine, Small / pathology. Male. Middle Aged. Nuclear Proteins / genetics. Signal Transduction / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 21042749.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
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69. Moon YW, Rha SY, Shin SJ, Chang H, Shim HS, Roh JK: Adenocarcinoma of the small bowel at a single Korean institute: management and prognosticators. J Cancer Res Clin Oncol; 2010 Mar;136(3):387-94
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  • [Title] Adenocarcinoma of the small bowel at a single Korean institute: management and prognosticators.
  • PURPOSE: Small bowel adenocarcinoma (SBA) is a rare malignancy with a poor outcome.
  • CONCLUSIONS: Early diagnosis is crucial to improve outcomes of SBA with respect to increasing resectability.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Intestinal Neoplasms / diagnosis. Intestinal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Algorithms. Chemotherapy, Adjuvant / methods. Chemotherapy, Adjuvant / utilization. Digestive System Surgical Procedures / methods. Female. Humans. Intestine, Small / pathology. Korea. Male. Middle Aged. Prognosis. Recurrence. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19760196.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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70. Czaykowski P, Hui D: Chemotherapy in small bowel adenocarcinoma: 10-year experience of the British Columbia Cancer Agency. Clin Oncol (R Coll Radiol); 2007 Mar;19(2):143-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapy in small bowel adenocarcinoma: 10-year experience of the British Columbia Cancer Agency.
  • AIMS: Small bowel adenocarcinoma (SBA) is a rare, frequently lethal, malignancy.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / drug therapy. Intestine, Small / drug effects

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  • (PMID = 17355111.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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71. Rautou PE, Hammel P, Couvelard A, Rivet P, Aubert A, Lévy P, Ruszniewski P: [Suspected malignant cancer of the pancreas associated with pseudo-invasive duodenal hamartomas in a patient with Peutz-Jeghers syndrome]. Gastroenterol Clin Biol; 2007 May;31(5):547-51
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  • [Transliterated title] Suspicion de tumeur pancréatique maligne liée à des hamartomes duodénaux pseudo-invasifs au cours d'un syndrome de Peutz-Jeghers.
  • A 29-year-old man with a previously known Peutz-Jeghers syndrome (PJS) was admitted for epigastric pain, emesis and weight loss due to both intestinal intussusception causing bowel obstruction and obstructive pancreatitis.
  • Because duodenal and/or pancreatic cancer was suspected due to weight loss, the pancreatic and bile duct obstruction, and the increased risk of small intestine and pancreatic adenocarcinoma in patients with PSJ, a pancreatoduodenectomy was performed.
  • [MeSH-major] Duodenal Diseases / complications. Hamartoma / complications. Intestinal Polyps / complications. Pancreatic Neoplasms / complications. Peutz-Jeghers Syndrome / complications


72. Triantafillidis JK, Nasioulas G, Kosmidis PA: Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res; 2009 Jul;29(7):2727-37
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  • [Title] Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.
  • Patients with long-standing ulcerative colitis and Crohn's disease have an increased risk of developing colorectal cancer and patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.
  • Colorectal cancer appearing on the ground of inflammatory bowel disease is the result of a process which is believed to begin from no dysplasia progressing to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma, although colorectal cancer can arise without proceeding through each of these steps.
  • [MeSH-major] Cell Transformation, Neoplastic. Colorectal Neoplasms / epidemiology. Inflammatory Bowel Diseases / epidemiology

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  • (PMID = 19596953.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Number-of-references] 94
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73. Daniels JA, Lederman HM, Maitra A, Montgomery EA: Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review. Am J Surg Pathol; 2007 Dec;31(12):1800-12
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  • METHODS: We reviewed clinical documentation and samples from 132 separate GI biopsy or resection sites on 20 CVID patients obtained over a 26-year period, including biopsies from the colon (34), esophagus (19), small intestine (38), and stomach (35), a partial gastrectomy, small bowel resection, colectomy, 2 cholecystectomies, and 1 appendectomy.
  • Age at diagnosis ranged from 6 months to 62 years (median, 35.5 y), and age at biopsy ranged from 10 months to 67 years (median, 38 y).
  • Gastric adenocarcinoma was identified in one patient.
  • There was a paucity of small bowel plasma cells in the majority of patients (68%).
  • The small bowel showed prominent lymphoid aggregates in about half (47%).
  • Its features can mimic lymphocytic colitis, collagenous enterocolitis, celiac disease, lymphocytic gastritis, granulomatous disease, acute graft-versus-host disease, and inflammatory bowel disease.
  • In fact, in our series, we found patients with a prior diagnosis of celiac disease (25%) and inflammatory bowel disease (35%), including Crohn disease (15%).
  • The diagnosis of CVID may be suspected on the basis of the lack of plasma cells in a GI biopsy, but because this feature is only present in about two-thirds of patients, the diagnosis cannot always be suggested in isolation of other clinical and laboratory findings.
  • [MeSH-minor] Adolescent. Adult. Aged. Celiac Disease / pathology. Child. Child, Preschool. Colitis, Collagenous / pathology. Colitis, Lymphocytic / pathology. Diagnosis, Differential. Female. Granulomatous Disease, Chronic / pathology. Humans. Infant. Inflammatory Bowel Diseases / pathology. Male. Middle Aged

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  • (PMID = 18043034.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Menon AM, Mirza AH, Moolla S, Morton DG: Adenocarcinoma of the small bowel arising from a previous strictureplasty for Crohn's disease: report of a case. Dis Colon Rectum; 2007 Feb;50(2):257-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the small bowel arising from a previous strictureplasty for Crohn's disease: report of a case.
  • Small-bowel adenocarcinoma is an uncommon tumor, comprising<2 percent of all gastrointestinal tract malignancies.
  • To date, there have been only two documented cases of adenocarcinoma arising at the site of previous strictureplasty reported in the literature.
  • We report the third such case in a patient with no other premalignant conditions affecting the small bowel and question whether we may see an increasing trend in this type of presentation.
  • [MeSH-major] Adenocarcinoma / pathology. Crohn Disease / pathology. Crohn Disease / surgery. Intestinal Neoplasms / pathology. Intestine, Small / pathology

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  • (PMID = 17180254.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Gore RM, Mehta UK, Berlin JW, Rao V, Newmark GM: Diagnosis and staging of small bowel tumours. Cancer Imaging; 2006;6:209-12
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  • [Title] Diagnosis and staging of small bowel tumours.
  • Small bowel neoplasms comprise only 1% of gastrointestinal neoplasms.
  • Despite their rarity, it is important to diagnose small bowel tumours early to maximize patient survival.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestine, Small
  • [MeSH-minor] Adenocarcinoma / diagnosis. Carcinoid Tumor / diagnosis. Gastrointestinal Stromal Tumors / diagnosis. Humans. Lymphoma / diagnosis. Magnetic Resonance Imaging. Neoplasm Staging. Tomography, X-Ray Computed

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  • [Copyright] (c) International Cancer Imaging Society.
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  • (PMID = 17208678.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 14
  • [Other-IDs] NLM/ PMC1766561
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76. Farrell S, Gray SB, Best BG: Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature. Int Surg; 2005 Apr-Jun;90(2):85-7
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  • [Title] Mucusuria--an unusual manifestation of ileal adenocarcinoma: a case report and review of the literature.
  • Primary adenocarcinoma of the ileum is an uncommon gastrointestinal malignancy, the symptoms of which are often insidious in onset.
  • This case history highlights the previously unreported finding of ileal adenocarcinoma presenting with mucusuria, caused by local invasion of the bladder in a 44-year-old male.
  • A review of the literature is included to highlight the incidence, risk factors, clinical presentation, investigation, and current management of adenocarcinoma of the small bowel.
  • [MeSH-major] Adenocarcinoma / secondary. Ileal Neoplasms / pathology. Intestinal Fistula / diagnosis. Urinary Bladder Fistula / diagnosis. Urinary Bladder Neoplasms / secondary

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  • (PMID = 16119711.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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77. Sammartino P, Sibio S, Di Giorgio A, Caronna R, Viscido A, Zippi M, Biacchi D, Accarpio F, Mingazzini P, Caprilli R: Two synchronous adenocarcinomas of the small bowel in a patient with undiagnosed Crohn's disease of the terminal ileum. Int J Colorectal Dis; 2006 May;21(4):388-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two synchronous adenocarcinomas of the small bowel in a patient with undiagnosed Crohn's disease of the terminal ileum.
  • A small but significant excess of deaths for tumors of the digestive system has been described in Crohn's disease.
  • In a study analyzing all cancers of the small intestine within a defined population, Crohn's disease was the major underlying factor for cancer of the small intestine.
  • Areas of the small intestine containing strictures are unusually prone to malignant transformation.
  • We report the rare case of a patient in whom surgery for intestinal occlusion disclosed Crohn's disease of the distal ileum complicated by two adenocarcinomas arising within distinct areas of the inflamed bowel.
  • [MeSH-major] Adenocarcinoma / pathology. Crohn Disease / diagnosis. Ileal Neoplasms / pathology
  • [MeSH-minor] Aged. Humans. Incidental Findings. Intestinal Obstruction / etiology. Intestinal Obstruction / surgery. Male

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  • (PMID = 16059693.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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78. Versaci A, Macrì A, Ieni A, Terranova M, Leonello G, Saladino E, Speciale G, Famulari C: [Gastrointestinal stromal tumour: our experience]. Chir Ital; 2009 Mar-Apr;61(2):161-9
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  • These tumours originate in Cajal interstitial cells and the majority are located in the stomach and small intestine.
  • Imaging difficulties impede an early diagnosis; sometimes these tumours represent an unexpected intraoperative finding or an emergency abdominal picture.
  • One patient, with two synchronous gastric neoplasms (GIST + adenocarcinoma) died after 16 months, while the other 5 patients with gastric GIST are still alive; two patients with ileal GIST, treated with chemotherapy, died after 15 and 18 months, respectively.

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  • (PMID = 19536989.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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79. Michalopoulos A, Papadopoulos V, Paramythiotis D, Papavramidis T, Douros V, Netta S, Mekras A, Apostolidis S: Colonic cancer in a patient with intestinal malrotation: a case report. Tech Coloproctol; 2010 Nov;14 Suppl 1:S65-6
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  • [Title] Colonic cancer in a patient with intestinal malrotation: a case report.
  • We present a case of a 76-year-old patient with intestinal malrotation, with incomplete rotation of the small intestine and abnormal positioning of the duodenum and superior mesenteric vessels over the transverse colon.
  • [MeSH-major] Adenocarcinoma / complications. Colonic Neoplasms / complications. Digestive System Abnormalities / complications. Intestinal Diseases / congenital. Intestines / abnormalities

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  • (PMID = 20683743.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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80. France M, Drew PA, Ruszkiewicz A, Jamieson GG, Watson DI: Use of ethylenediaminetetraacetic acid for in vivo stripping of columnar mucosa: pilot study in an experimental model. ANZ J Surg; 2006 May;76(5):392-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Barrett's oesophagus is an important clinical problem that can lead to oesophageal adenocarcinoma.
  • To determine the feasibility of using EDTA to strip intestinal type mucosa, segments of the small intestine were exposed in vitro to EDTA at various concentrations with or without agitation.
  • The conditions required for EDTA to strip mucosa from a vascularized loop of small bowel were then optimized in vivo.
  • Cannulated small bowel loops were irrigated with different concentrations of EDTA with or without pulsation of the irrigation solution.
  • Mucosal healing after EDTA stripping was studied in an isolated small bowel loop survival model.
  • RESULTS: Ethylenediaminetetraacetic acid with agitation or pulsation resulted in stripping of the intestinal columnar mucosa in vitro and in vivo.
  • In the survival model the small bowel mucosa regenerated without stricture formation.
  • CONCLUSION: Small bowel columnar mucosa can be removed by EDTA in vivo without stricture formation.
  • [MeSH-major] Chelating Agents / pharmacology. Edetic Acid / pharmacology. Esophagus / drug effects. Intestinal Mucosa / drug effects. Jejunum / drug effects

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  • (PMID = 16768702.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Chelating Agents; 9G34HU7RV0 / Edetic Acid
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81. Li S, Li Y, Tang L, Zhao P: Obstructed small bowel ruptured toward the inguinal canal resulting from metastatic colon carcinoma in an irreducible, recurrent inguinal hernia with mesh-plug repair: Report of a case. Eur J Surg Oncol; 2010 Oct;36(10):1012-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Obstructed small bowel ruptured toward the inguinal canal resulting from metastatic colon carcinoma in an irreducible, recurrent inguinal hernia with mesh-plug repair: Report of a case.
  • Delayed surgical exploration revealed metastatic cancer with small bowel adhesion to the mesh-plug and perforation.
  • The mesh-plug with adherent tissue was removed through the inguinal incision, and the ruptured small bowel was resected.
  • Histopathology revealed moderately differentiated mucinous adenocarcinoma of the tissue adhering to the prosthetic material corresponding to the original colon cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Hernia, Inguinal / surgery. Intestinal Obstruction / pathology. Intestine, Small / surgery. Sigmoid Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20138732.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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82. Sakai Y, Tsuyuguchi T, Ohara T, Yukisawa S, Tsuchiya S, Sugiyama H, Miyakhawa K, Ohbu M, Kato K, Kimura M, Kaiho T, Takeuchi O, Matsuzaki O, Miyazaki M, Yokosuka O: A patient with adenocarcinoma of the jejunum successfully diagnosed by preoperative endoscopy for the small intestine. Hepatogastroenterology; 2008 Jul-Aug;55(85):1367-9
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  • [Title] A patient with adenocarcinoma of the jejunum successfully diagnosed by preoperative endoscopy for the small intestine.
  • In this study, the authors report the case of a 35-year-old man diagnosed preoperatively as having adenocarcinoma of the jejunum using a conventional endoscopy, usually used for the examination of the large intestine.
  • [MeSH-major] Adenocarcinoma / pathology. Endoscopy. Jejunal Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Ileus / diagnosis. Ileus / etiology. Ileus / surgery. Intestine, Small. Male

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  • (PMID = 18795691.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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83. Cheung DY, Lee IS, Chang DK, Kim JO, Cheon JH, Jang BI, Kim YS, Park CH, Lee KJ, Shim KN, Ryu JK, Do JH, Moon JS, Ye BD, Kim KJ, Lim YJ, Choi MG, Chun HJ, Korean Gut Images Study Group: Capsule endoscopy in small bowel tumors: a multicenter Korean study. J Gastroenterol Hepatol; 2010 Jun;25(6):1079-86
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  • [Title] Capsule endoscopy in small bowel tumors: a multicenter Korean study.
  • BACKGROUND AND AIM: Capsule endoscopy (CE) has proven to be highly effective at detecting small bowel lesions in a variety of clinical conditions, but studies concerning the practical impact of CE on small bowel tumors are still scarce, especially in the Asian population.
  • The aim of this study was to evaluate the diagnostic and therapeutic impact of CE in the field of small bowel tumors.
  • Clinical information and CE video images of small bowel tumors were analyzed.
  • Small bowel tumors were diagnosed with CE in 57 (4.3%) of 1332 patients.
  • The tumors were malignant in 33 cases, and included three adenocarcinomas, eight lymphomas, 20 gastrointestinal stromal tumors, and two metastatic cancers.
  • CONCLUSION: CE effectively identifies small bowel tumors that are undetectable by conventional radiological studies (diagnostic impact = 52.6%) and can critically change the therapeutic course (therapeutic impact = 12.3%).
  • [MeSH-major] Capsule Endoscopy / methods. Ileal Neoplasms / diagnosis. Intestine, Small. Jejunal Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / epidemiology. Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / epidemiology. Humans. Incidence. Korea / epidemiology. Lymphoma / diagnosis. Lymphoma / epidemiology. Male. Middle Aged. Reproducibility of Results. Retrospective Studies

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  • (PMID = 20594222.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Australia
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84. Palascak-Juif V, Bouvier AM, Cosnes J, Flourié B, Bouché O, Cadiot G, Lémann M, Bonaz B, Denet C, Marteau P, Gambiez L, Beaugerie L, Faivre J, Carbonnel F: Small bowel adenocarcinoma in patients with Crohn's disease compared with small bowel adenocarcinoma de novo. Inflamm Bowel Dis; 2005 Sep;11(9):828-32
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  • [Title] Small bowel adenocarcinoma in patients with Crohn's disease compared with small bowel adenocarcinoma de novo.
  • BACKGROUND: Data concerning small bowel adenocarcinoma (SBA) in Crohn's disease (CD) come from case reports and small retrospective series.
  • The aim of this study was to further describe SBA in patients with CD and compare it with SBA de novo.
  • METHODS: Twenty patients with CD with SBA recruited in French university hospitals were studied and compared with 40 patients with SBA de novo recruited from a population-based registry.
  • SBA occurred after a median time of 15 years of CD and was located within the inflamed areas of the ileum (n=19) or jejunum (n=1), whereas in patients with SBA de novo, it was distributed all along the small intestine.
  • Median age at diagnosis of SBA was 47 years (range, 33-72 yr) in patients with CD and 68 years (range, 41-95 yr) in those with SBA de novo.
  • Diagnosis was made preoperatively in 1/20 patients with CD and 22/40 patients with SBA de novo.
  • Signet ring cells were found in 35% of patients with CD but not in patients with SBA de novo.
  • CONCLUSIONS: SBA in CD is different from SBA de novo.
  • [MeSH-major] Adenocarcinoma / pathology. Crohn Disease / complications. Ileal Neoplasms / pathology


85. Yakan S, Caliskan C, Makay O, Denecli AG, Korkut MA: Intussusception in adults: clinical characteristics, diagnosis and operative strategies. World J Gastroenterol; 2009 Apr 28;15(16):1985-9
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  • [Title] Intussusception in adults: clinical characteristics, diagnosis and operative strategies.
  • AIM: To evaluate 20 adults with intussusception and to clarify the cause, clinical features, diagnosis, and management of this uncommon entity.
  • METHODS: A retrospective review of patients aged > 18 years with a diagnosis of intestinal intussusception between 2000 and 2008.
  • The majority of intussusceptions were in the small intestine (85%).
  • Among enteric intussusceptions, 14 were secondary to a benign process, and in one of these, the malignant cause was secondary to metastatic lung adenocarcinoma.
  • Treatment usually requires resection of the involved bowel segment.
  • Reduction can be attempted in small-bowel intussusception if the segment involved is viable or malignancy is not suspected; however, a more careful approach is recommended in colonic intussusception because of a significantly higher coexistence of malignancy.
  • [MeSH-major] Intussusception / diagnosis. Intussusception / surgery

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  • (PMID = 19399931.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2675089
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86. Chaïbi C, Cotte-Laffitte J, Sandré C, Esclatine A, Servin AL, Quéro AM, Géniteau-Legendre M: Rotavirus induces apoptosis in fully differentiated human intestinal Caco-2 cells. Virology; 2005 Feb 20;332(2):480-90
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  • [Title] Rotavirus induces apoptosis in fully differentiated human intestinal Caco-2 cells.
  • Rotaviruses, which are the main cause of viral gastroenteritis in young children, induce structural and functional damages in infected mature enterocytes of the small intestine.
  • To investigate a relationship between rotavirus infection and cell death by apoptosis, we used the human intestinal Caco-2 cell line.
  • [MeSH-minor] Adenocarcinoma. Annexin A5 / metabolism. Cell Differentiation. Cell Line, Tumor. Colonic Neoplasms. Cytochromes c / analysis. Flow Cytometry. Humans. In Situ Nick-End Labeling. Membrane Potentials / physiology. Mitochondria / physiology

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  • (PMID = 15680413.001).
  • [ISSN] 0042-6822
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Annexin A5; 9007-43-6 / Cytochromes c
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87. Niwa Y, Nakamura M, Omiya N, Itoh A, Hirooka Y, Goto H: Ileal cancer and erosions in the small intestine revealed by capsule endoscopy. Endoscopy; 2007 Feb;39 Suppl 1:E7-8
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  • [Title] Ileal cancer and erosions in the small intestine revealed by capsule endoscopy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Capsule Endoscopy. Colonic Neoplasms / diagnosis. Endoscopy, Gastrointestinal. Enteritis / diagnosis. Gastrointestinal Hemorrhage / diagnosis. Ileal Neoplasms / diagnosis. Intestinal Polyps / diagnosis. Neoplasms, Multiple Primary / diagnosis

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  • (PMID = 17285495.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Quinolones; 111911-87-6 / rebamipide; OF5P57N2ZX / Alanine
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88. Schwartz GD, Barkin JS: Small-bowel tumors detected by wireless capsule endoscopy. Dig Dis Sci; 2007 Apr;52(4):1026-30
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  • [Title] Small-bowel tumors detected by wireless capsule endoscopy.
  • Small bowel tumors are difficult to diagnose because of their endoscopic inaccessibility.
  • The purpose of this report is to describe the largest series of patients with small bowel tumors detected by capsule endoscopy.
  • Eighty six patients were derived from the Given Imaging clinical database on a survey of Pillcam SB capsule users who were diagnosed with 87 small bowel tumors, 1 cecal tumor, and 1 gastric tumor.
  • Of the 87 reported small bowel tumors, 4 were identified in the duodenum, 43 tumors were identified in the jejunum, 18 tumors were identified in the ileum, and 22 tumors were located in the mid to distal small bowel.
  • The most common malignant tumors were adenocarcinoma, carcinoids, melanomas, lymphomas, and sarcomas.
  • Capsule endoscopy is the diagnostic procedure of choice in patients with suspected small bowel tumors.
  • [MeSH-major] Capsule Endoscopy. Endoscopy, Gastrointestinal. Intestinal Neoplasms / diagnosis. Intestine, Small

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  • (PMID = 17380403.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Mastoraki A, Konstantiadou I, Papanikolaou I, Christodolou S, Sakorafas G, Peros G: Adenocarcinoma of the small intestine complicating Crohn's disease. Int J Colorectal Dis; 2009 Oct;24(10):1245-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the small intestine complicating Crohn's disease.
  • [MeSH-major] Adenocarcinoma / complications. Crohn Disease / complications. Intestinal Neoplasms / complications
  • [MeSH-minor] Adult. Aged. Humans. Incidence. Intestinal Obstruction / complications. Male. Middle Aged. Spondylitis, Ankylosing / complications

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  • (PMID = 19408004.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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90. Gupta C, Malani AK, Rangineni S: Breast metastasis of ilial carcinoid tumor: case report and literature review. World J Surg Oncol; 2006;4:15
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  • CASE PRESENTATION: We report a case of unilateral breast metastasis from carcinoid tumor of the small intestine in a 52-year-old woman who was successfully treated by lumpectomy and radiation therapy.
  • An extensive review of the literature reveals only a few cases of metastatic carcinoid to the breast from small intestinal primaries.
  • Their histological appearance may mimic ductal adenocarcinoma of the breast.

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  • (PMID = 16566835.001).
  • [ISSN] 1477-7819
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91. Shenderey RL, Thompson N, Mansfield JC, Rees C: Adenocarcinoma as a complication of small bowel Crohn's disease. Eur J Gastroenterol Hepatol; 2005 Nov;17(11):1255-7
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  • [Title] Adenocarcinoma as a complication of small bowel Crohn's disease.
  • Carcinoma is a recognized but rare complication of small bowel Crohn's disease.
  • This case series emphasizes the importance of considering this diagnosis in patients with small bowel Crohn's disease.
  • We report three cases in which patients were treated for presumed exacerbations of Crohn's, but were subsequently found to have underlying small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / etiology. Crohn Disease / complications. Ileal Neoplasms / etiology. Jejunal Neoplasms / etiology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Intestinal Obstruction / etiology. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16215441.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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92. Xie J, Itzkowitz SH: Cancer in inflammatory bowel disease. World J Gastroenterol; 2008 Jan 21;14(3):378-89
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  • [Title] Cancer in inflammatory bowel disease.
  • Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC).
  • Colon cancer risk in inflammatory bowel disease increases with longer duration of colitis, greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of the bowel.
  • Patients with small intestinal Crohn's disease are at increased risk of small bowel adenocarcinoma.
  • Other extra intestinal cancers, such as hepatobiliary and hematopoietic cancer, have shown variable incidence rates.
  • [MeSH-major] Colorectal Neoplasms / physiopathology. Inflammatory Bowel Diseases / physiopathology. Neoplasms / physiopathology

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  • (PMID = 18200660.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 118
  • [Other-IDs] NLM/ PMC2679126
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93. Gustafsson BI, Siddique L, Chan A, Dong M, Drozdov I, Kidd M, Modlin IM: Uncommon cancers of the small intestine, appendix and colon: an analysis of SEER 1973-2004, and current diagnosis and therapy. Int J Oncol; 2008 Dec;33(6):1121-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uncommon cancers of the small intestine, appendix and colon: an analysis of SEER 1973-2004, and current diagnosis and therapy.
  • Although colon adenocarcinomas constitute approximately 90% of all malignant intestinal neoplasia, the remaining 10% of tumors in the small intestine (SI), appendix and colon are clinically relevant since their late presentation due to a paucity of overt symptoms culminates in a high mortality rate despite the fact that many such lesions are not intrinsically aggressive neoplasia.
  • Thus, neuroendocrine tumors (NETs), adenocarcinomas (except for colonic), lymphomas, sarcomas and GI stromal tumors (GISTs) of the SI, appendix and colon, while relatively rare, represent an under-recognized and underserved group of lesions.
  • According to the SEER registry 1973-2004, the incidence/100,000 of sarcomas has remained unchanged, while NETs, adenocarcinomas (except colon), and lymphomas have increased 2.9-, 1.6-, and 2.0-fold, respectively.
  • [MeSH-major] Appendiceal Neoplasms / epidemiology. Colonic Neoplasms / epidemiology. Intestinal Neoplasms / epidemiology. Intestine, Small / pathology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Gastrointestinal Stromal Tumors / epidemiology. Humans. Lymphoma / epidemiology. Neuroendocrine Tumors / epidemiology. SEER Program. Sarcoma / epidemiology. Survival Analysis. Time Factors. Treatment Outcome. United States / epidemiology

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  • (PMID = 19020744.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Greece
  • [Number-of-references] 68
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94. Park ET, Oh HK, Gum JR Jr, Crawley SC, Kakar S, Engel J, Leow CC, Gao WQ, Kim YS: HATH1 expression in mucinous cancers of the colorectum and related lesions. Clin Cancer Res; 2006 Sep 15;12(18):5403-10
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  • PURPOSE: Mucinous cancers and signet ring carcinomas are distinct classes of colon cancers characterized by their production of copious quantities of intestinal goblet cell mucin, MUC2.
  • Deletion of transcription factor HATH1 ablates the biogenesis of goblet cells in developing mouse intestine, and forced expression of HATH1 results in elevated expression of MUC2 in colon cancer cells.
  • EXPERIMENTAL DESIGN: Immunohistochemistry and confocal microscopy was used to examine HATH1 expression and subcellular distribution in normal colon and small intestine, mucinous cancers, signet ring carcinomas, and nonmucinous cancers and in precursor lesions, including hyperplastic polyps, serrated adenomas, tubular adenomas, and villous adenomas.
  • In the small intestine, only cytoplasmic expression of HATH1 in enteroendocrine cells was detected.
  • CONCLUSIONS: This study confirms the importance of HATH1 for the development of intestinal secretory cells.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Basic Helix-Loop-Helix Transcription Factors / metabolism. Colorectal Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Humans. Intestinal Polyps / pathology. Intestines / cytology. Intestines / ultrastructure. Male. Microscopy, Fluorescence. Middle Aged. Mucin-2. Mucins / metabolism. Promoter Regions, Genetic. Tissue Distribution. Transcriptional Activation

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  • (PMID = 17000673.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATOH1 protein, human; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / MUC2 protein, human; 0 / Muc2 protein, mouse; 0 / Mucin-2; 0 / Mucins
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95. Bakker JR, Haber MM, Garcia FU: Gastrointestinal neurofibromatosis: an unusual cause of gastric outlet obstruction. Am Surg; 2005 Feb;71(2):100-5
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  • Neoplasms were located most often in the small intestine (72%).
  • Adenocarcinoma was present in 23 per cent of patients.

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  • (PMID = 16022006.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 67
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96. Garrido A, Luque A, Vázquez A, Hernández JM, Alcántara F, Márquez JL: [Primary small bowel neoplasms as a complication of celiac disease]. Gastroenterol Hepatol; 2009 Nov;32(9):618-21
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  • [Title] [Primary small bowel neoplasms as a complication of celiac disease].
  • [Transliterated title] Neoplasias primarias de intestino delgado como complicación de la enfermedad celíaca.
  • The most serious complication in these patients is the development of neoplasms, the most frequent being enteropathy-associated T-cell lymphoma; however, an increase in the incidence of small bowel adenocarcinoma has also been described.
  • We present two cases of small bowel carcinoma in patients with celiac disease, which were diagnosed at the onset of the disease.
  • [MeSH-major] Adenocarcinoma / etiology. Celiac Disease / complications. Duodenal Neoplasms / etiology. Ileal Neoplasms / etiology

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  • (PMID = 19625106.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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97. Jo DH, Cheung DY, Kim HK, Son DK, Chung JS, Kim JI, Park SH, Han JY, Kim JK, Chung KW: [Small bowel metastasis from breast cancer: a case report]. Korean J Gastroenterol; 2005 Aug;46(2):137-41
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  • [Title] [Small bowel metastasis from breast cancer: a case report].
  • We describe a 73-year-old woman with small intestinal metastasis of breast cancer.
  • During investigation for lower abdominal pain and weight loss of 9 kg, we found a small bowel mass.
  • The histology of the tissue taken from small bowel mass was adenocarcinoma, poorly differentiated.
  • This is a case of small bowel metastasis from breast cancer and we report this case with a review of literatures.
  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / pathology. Intestinal Neoplasms / secondary
  • [MeSH-minor] Aged. Female. Humans. Intestine, Small

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  • (PMID = 16118525.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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98. Catena F, Ansaloni L, Gazzotti F, Gagliardi S, Di Saverio S, De Cataldis A, Taffurelli M: Small bowel tumours in emergency surgery: specificity of clinical presentation. ANZ J Surg; 2005 Nov;75(11):997-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small bowel tumours in emergency surgery: specificity of clinical presentation.
  • BACKGROUND: Despite advances in diagnostic modalities, small bowel tumours are notoriously difficult to diagnose and are often advanced at the time of definitive treatment.
  • The aim of the present study was to describe the clinical presentation, diagnostic work-up, surgical therapy and short-term outcome of 34 patients with primary and secondary small bowel tumours submitted for surgical procedures in an emergency setting and to look for a correlation between clinical presentation and the type of tumours.
  • METHODS: From 1995 to 2005, 34 consecutive surgical cases of small bowel tumours were treated at the Department of Emergency Surgery of St Orsola-Malpighi University Hospital, Bologna, Italy.
  • RESULTS: All patients presented as surgical emergencies: intestinal obstruction was the most common clinical presentation (15 cases), followed by perforation (11 cases) and gastrointestinal bleeding (eight cases).
  • Lymphoma was the most frequent histologic type (nine patients), followed by stromal tumours (eight patients), carcinoids (seven patients), adenocarcinoma (seven patients) and metastasis (three patients).
  • Of the nine patients with lymphoma, eight were perforated, all patients with stromal tumours had bleeding, and all carcinoids patients had bowel obstruction.
  • There were two patients with melanoma metastasis, both had bowel intussusception.
  • CONCLUSIONS: The present study shows that there is a correlation between small bowel tumours and clinical emergency presentation: gastrointestinal stromal tumours (GIST) mostly bleed; carcinoids make an obstruction; lymphomas cause a perforation; and melanoma metastasis causes intussusception.
  • [MeSH-major] Intestinal Neoplasms / complications
  • [MeSH-minor] Adenocarcinoma / complications. Adult. Aged. Aged, 80 and over. Carcinoid Tumor / complications. Emergency Service, Hospital. Female. Gastrointestinal Hemorrhage / etiology. Gastrointestinal Stromal Tumors / complications. Humans. Intestinal Obstruction / etiology. Intestinal Obstruction / surgery. Intestinal Perforation / etiology. Intestinal Perforation / surgery. Intestine, Small. Intussusception / etiology. Lymphoma / complications. Male. Melanoma / complications. Middle Aged. Neoplasm Metastasis. Retrospective Studies

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  • (PMID = 16336396.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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99. Turan M, Karadayi K, Duman M, Ozer H, Arici S, Yildirir C, Koçak O, Sen M: Small bowel tumors in emergency surgery. Ulus Travma Acil Cerrahi Derg; 2010 Jul;16(4):327-33
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  • [Title] Small bowel tumors in emergency surgery.
  • BACKGROUND: The aim of the present study was to describe the clinical presentation, diagnostic work-up, surgical therapy, and prognosis of 13 patients with small bowel tumor admitted for surgical procedures in an emergency setting.
  • METHODS: From 1996 to 2008, 13 consecutive surgical cases of small bowel tumors were treated at the Cumhuriyet University Faculty of Medicine, Department of General Surgery, and Kütahya State Hospital, Department of General Surgery.
  • RESULTS: Intestinal obstruction (7 cases) and perforation (5 cases) were the most common clinical presentations, followed by intussusception (1 case).
  • Adenocarcinoma was the most frequent histologic type (4 cases), while small bowel sarcoma was seen in three cases and non-Hodgkin lymphoma in two cases.
  • The remaining cases had carcinoid tumor, small bowel angioleiomyoma, Brunner's gland adenoma, and inflammatory pseudotumor of the small intestine.
  • CONCLUSION: Small bowel tumors are rare, the symptoms often non-specific, and the accuracy of different diagnostic tests remains to be improved.
  • [MeSH-major] Adenocarcinoma / surgery. Emergencies. Intestinal Neoplasms / surgery. Surgical Procedures, Operative / methods
  • [MeSH-minor] Angiomyoma / surgery. Hemangiosarcoma / surgery. Humans. Intestinal Obstruction / etiology. Intestinal Perforation / etiology. Leiomyosarcoma / surgery. Retrospective Studies

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  • (PMID = 20849049.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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100. Vagholkar K, Mathew T: Adenocarcinoma of the small bowel: a surgical dilemma. Saudi J Gastroenterol; 2009 Oct-Dec;15(4):264-7
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  • [Title] Adenocarcinoma of the small bowel: a surgical dilemma.
  • Malignant tumors of the small intestine are among the rarest types of gastrointestinal cancers.
  • Due to their infrequent occurrence and the multitude of tumor types (viz, adenocarcinomas, carcinoids, sarcomas, and lymphomas), not much is known about their natural history and presentation, and there is often delay in the diagnosis.
  • Adenocarcinoma is the commonest histologic type of small bowel cancer.
  • In this article, a case of adenocarcinoma of the jejunum presenting as an abdominal lump is presented, along with a review of the literature.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Jejunal Neoplasms / pathology. Jejunal Neoplasms / surgery

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  • [Journal-full-title] Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
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