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1. Uña E, Cuadrillero F, López-Lara F: Drug extravasation: a dreaded complication. BMJ Case Rep; 2009;2009
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 62-year-old man diagnosed with a stage I lung adenocarcinoma was treated by an upper right lobectomy.
  • The diagnosis of delayed and distant docetaxel extravasation was made.
  • This reaction resolved over the next 6 weeks, leaving two areas of brownish pigmentation of the skin as the only sequelae.

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  • [Cites] Pharmacotherapy. 1999 Aug;19(8):1002-5 [10453974.001]
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  • (PMID = 21686582.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028026
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2. Gómez-Diez S, García-García B, Fernández-García MS, Pérez-Oliva N: [Skin metastases as the initial presentation of pancreatic carcinoma]. Actas Dermosifiliogr; 2010 Jan-Feb;101(1):93-5
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  • [Title] [Skin metastases as the initial presentation of pancreatic carcinoma].
  • [MeSH-major] Adenocarcinoma / secondary. Head and Neck Neoplasms / secondary. Pancreatic Neoplasms / diagnosis. Scalp / pathology. Skin Neoplasms / secondary

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  • (PMID = 20109401.001).
  • [ISSN] 1578-2190
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] Spain
  • [Number-of-references] 12
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3. Barbagelata López A, Ruibal Moldes M, Blanco Díez A, Fernández Rosado E, Ponce Díaz-Reixa JL, Novas Castro S, Lancina Martín A, González Martín M: [Cutaneous metastasis of a renal carcinoma: case report and review]. Arch Esp Urol; 2005 Apr;58(3):247-50
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  • OBJECTIVES: To report another rare case of skin metastasis from a renal adenocarcinoma, analyzing the prognostic significance, response to therapy, and clinical presentation after a bibliographic review.
  • METHODS/RESULTS: We report the case of a 65-year-old male with a cutaneous metastasis in the root of his inferior left extremity one year after right nephrectomy for a clear cell adenocarcinoma.
  • CONCLUSIONS: Skin metastases usually present as solitary cutaneous lesions of variable macroscopic features and rapid growing; the diagnosis is made by histological analysis, being excision the treatment of choice whenever possible.
  • Prognosis is better for solitary lesions appearing asynchronously with the primary tumor, and among them the longer the time after diagnosis of initial lesion they appear the better the prognosis.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 15906619.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 9
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4. Soeda A, Morita-Hoshi Y, Kaida M, Wakeda T, Yamaki Y, Kojima Y, Ueno H, Kondo S, Morizane C, Ikeda M, Okusaka T, Heike Y: Long-term administration of Wilms tumor-1 peptide vaccine in combination with gemcitabine causes severe local skin inflammation at injection sites. Jpn J Clin Oncol; 2010 Dec;40(12):1184-8
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  • [Title] Long-term administration of Wilms tumor-1 peptide vaccine in combination with gemcitabine causes severe local skin inflammation at injection sites.
  • The skin toxicity of vaccine therapy at injection sites is generally limited to Grades 1-2 due to the nature of their function.
  • These patients requested to continue the treatment after the study period; however, in the course of compassionate use, they developed unacceptable local skin reactions and terminated their vaccine treatment.
  • Skin toxicity occurred at 6.4-8.4 months and continued for several months after the final vaccination during gemcitabine treatment.
  • Therefore, we need to monitor patients for late-onset, severe and long-lasting skin reactions at injection sites in Wilms tumor-1 cancer vaccine therapy, particularly for combination treatment with gemcitabine.
  • [MeSH-major] Bone Neoplasms / drug therapy. Cancer Vaccines / administration & dosage. Cancer Vaccines / adverse effects. Deoxycytidine / analogs & derivatives. Dermatitis / etiology. Liver Neoplasms / drug therapy. Nuclear Proteins / administration & dosage. Nuclear Proteins / adverse effects. Skin / drug effects
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Aged. Antimetabolites, Antineoplastic / administration & dosage. Antimetabolites, Antineoplastic / adverse effects. Chemotherapy, Adjuvant. Cholangiocarcinoma / drug therapy. Cholangiocarcinoma / secondary. Drug Administration Schedule. Female. Gallbladder Neoplasms / pathology. Humans. Injections, Intradermal / adverse effects. Lymphocytes / immunology. Palliative Care / methods. Radiotherapy, Adjuvant

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  • (PMID = 20656693.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Cancer Vaccines; 0 / Nuclear Proteins; 0 / WTAP protein, human; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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5. Sztanke K, Tuzimski T, Rzymowska J, Pasternak K, Kandefer-Szerszeń M: Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. Eur J Med Chem; 2008 Feb;43(2):404-19
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  • Compounds 7 and 12 were evaluated for their cytotoxic activity against three cancer cell lines: human Caucasian colon adenocarcinoma cell line - LS180 (ECACC 87021202), human uterus carcinoma cell line - SiHa (ECACC 85060701) and human breast carcinoma cell line - T47D (ECACC 85102201).
  • Compound 12 was found to be the most effective in vitro against human colon adenocarcinoma cell line (LS180).
  • Moreover, the distinctly marked lower cytotoxicity of compounds 7 and 12 against the normal cell line - human skin fibroblasts (HSF) and almost several-fold higher against the examined cancer cell lines was ascertained.

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  • (PMID = 17531354.001).
  • [ISSN] 0223-5234
  • [Journal-full-title] European journal of medicinal chemistry
  • [ISO-abbreviation] Eur J Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Antineoplastic Agents; 0 / Lipids; 0 / Triazoles
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6. Gazoni LM, Hedrick TL, Smith PW, Friel CM, Swenson BR, Adams JD, Lisle TC, Foley EF, Ledesma EJ: Cutaneous metastases in patients with rectal cancer: a report of six cases. Am Surg; 2008 Feb;74(2):138-40
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  • The diagnosis of rectal cancer was made concurrently with the diagnosis of the dermal metastases in all six patients.
  • No patient survived more than 7 months from the time of diagnosis.
  • Recognition of suspicious skin lesions as possible harbingers of undiagnosed visceral malignancy is important in managing patients both with and without a history of previous cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Rectal Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 18306865.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Mitra SS, Simcock R: Erlotinib induced skin rash spares skin in previous radiotherapy field. J Clin Oncol; 2006 Jun 1;24(16):e28-9
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  • [Title] Erlotinib induced skin rash spares skin in previous radiotherapy field.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Brain Neoplasms / drug therapy. Drug Eruptions / prevention & control. Lung Neoplasms / radiotherapy. Quinazolines / adverse effects. Skin / radiation effects

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  • [CommentIn] J Clin Oncol. 2007 May 20;25(15):2140; author reply 2141 [17513824.001]
  • [CommentIn] J Clin Oncol. 2007 Oct 10;25(29):4697-8; author reply 4698-9 [17925571.001]
  • (PMID = 16735697.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride
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8. Perrotto J, Abbott JJ, Ceilley RI, Ahmed I: The role of immunohistochemistry in discriminating primary from secondary extramammary Paget disease. Am J Dermatopathol; 2010 Apr;32(2):137-43
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  • Notably, all 6 of 7 cases of EMPD secondary to an anorectal adenocarcinoma tested were HER-2/neu negative and 5 of those 6 cases (80%) were CDX2 positive.
  • An expanded immunohistochemical panel, including HER-2/neu and CDX2, may be useful in discriminating primary EMPD from EMPD secondary to anorectal adenocarcinoma but fails to distinguish primary EMPD from EMPD secondary to urothelial or prostatic malignancy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Immunohistochemistry / methods. Paget Disease, Extramammary / diagnosis. Paget Disease, Extramammary / secondary. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Carrier Proteins / metabolism. Diagnosis, Differential. Female. Glycoproteins / metabolism. Homeodomain Proteins / metabolism. Humans. Keratin-20 / metabolism. Keratin-7 / metabolism. Male. Middle Aged. Prostatic Neoplasms / pathology. Receptor, ErbB-2 / metabolism. Rectal Neoplasms / pathology. Retrospective Studies. Urologic Neoplasms / pathology


9. Han C, Chen YJ, Liu A, Schultheiss TE, Wong JY: Dosimetric study and in-vivo dose verification for conformal avoidance treatment of anal adenocarcinoma using helical tomotherapy. Med Dosim; 2007;32(1):33-7
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  • [Title] Dosimetric study and in-vivo dose verification for conformal avoidance treatment of anal adenocarcinoma using helical tomotherapy.
  • This study evaluated the efficacy of using helical tomotherapy for conformal avoidance treatment of anal adenocarcinoma.
  • In-vivo skin dose measurements were performed during conformal avoidance helical tomotherapy treatment of an anal cancer patient to verify adequate delivery of skin dose and sparing of OARs.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Anus Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated / methods. Tomography, Spiral Computed / methods
  • [MeSH-minor] Female. Humans. Male. Radiotherapy Dosage. Skin / radiation effects

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  • (PMID = 17317533.001).
  • [ISSN] 0958-3947
  • [Journal-full-title] Medical dosimetry : official journal of the American Association of Medical Dosimetrists
  • [ISO-abbreviation] Med Dosim
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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10. Berlin AL, Amin SP, Goldberg DJ: Extraocular sebaceous carcinoma treated with Mohs micrographic surgery: report of a case and review of literature. Dermatol Surg; 2008 Feb;34(2):254-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Sebaceous / surgery. Mohs Surgery / methods. Sebaceous Gland Neoplasms / surgery

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  • (PMID = 18093187.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Bennis Y, Guillet B, Curti C, Pisano P: [Interests in angiogenesis inhibitor drugs approved for the treatment of cancers]. Therapie; 2010 Mar-Apr;65(2):95-105
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Humanized. Antineoplastic Agents / therapeutic use. Benzenesulfonates / therapeutic use. Bevacizumab. Carcinoma, Hepatocellular / drug therapy. Humans. Indoles / therapeutic use. Kidney Neoplasms / drug therapy. Liver Neoplasms / drug therapy. Lung Neoplasms / drug therapy. Niacinamide / analogs & derivatives. Pancreatic Neoplasms / drug therapy. Phenylurea Compounds. Pyridines / therapeutic use. Pyrroles / therapeutic use. Skin Neoplasms / drug therapy

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  • [Copyright] 2010 Société Française de Pharmacologie et de Thérapeutique.
  • (PMID = 20478241.001).
  • [ISSN] 0040-5957
  • [Journal-full-title] Thérapie
  • [ISO-abbreviation] Therapie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Indoles; 0 / Phenylurea Compounds; 0 / Pyridines; 0 / Pyrroles; 0 / sunitinib; 25X51I8RD4 / Niacinamide; 2S9ZZM9Q9V / Bevacizumab; 9ZOQ3TZI87 / sorafenib
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12. Lièvre A, Bachet JB, Boige V, Cayre A, Le Corre D, Buc E, Ychou M, Bouché O, Landi B, Louvet C, André T, Bibeau F, Diebold MD, Rougier P, Ducreux M, Tomasic G, Emile JF, Penault-Llorca F, Laurent-Puig P: KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol; 2008 Jan 20;26(3):374-9
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  • The association between KRAS mutations and tumor response, skin toxicity, progression-free survival (PFS) and overall survival (OS) was analyzed.
  • When we pooled these 89 patients with patients from our previous study, the multivariate analysis showed that KRAS status was an independent prognostic factor associated with OS and PFS, whereas skin toxicity was only associated with OS.
  • In a combined analysis, median OS times of patients with two, one, or no favorable prognostic factors (severe skin toxicity and no KRAS mutation) was of 15.6, 10.7, and 5.6 months, respectively.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / genetics. Adenocarcinoma / mortality. Antibodies, Monoclonal, Humanized. Cetuximab. Humans. Male. Middle Aged. Prognosis. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Receptor, Epidermal Growth Factor / genetics. Receptor, Epidermal Growth Factor / metabolism. Retrospective Studies. Survival Rate


13. Cianchini G, Lembo L, Colonna L, Puddu P: Pemphigus foliaceus induced by radiotherapy and responsive to dapsone. J Dermatolog Treat; 2006;17(4):244-6
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  • We describe the case of a 70-year-old female who developed pemphigus foliaceus after X-ray treatment for an adenocarcinoma of the left breast.
  • Skin lesions were completely responsive to dapsone therapy.
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Aged. Breast Neoplasms / radiotherapy. Female. Humans

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  • (PMID = 16971322.001).
  • [ISSN] 0954-6634
  • [Journal-full-title] The Journal of dermatological treatment
  • [ISO-abbreviation] J Dermatolog Treat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 8W5C518302 / Dapsone
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14. Miccoli P, Ambrosini CE, Berti P: Video-assisted surgery: what is its role in the treatment of thyroid carcinoma? Minerva Endocrinol; 2009 Mar;34(1):71-80
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  • Through a 1.5 cm central skin incision 2 cm above the sternal notch MIVAT allows to perform a total thyroidectomy for low risk papillary carcinoma with a completeness similar to that of conventional thyroidectomy.
  • [MeSH-minor] Adenocarcinoma, Follicular / surgery. Adult. Age Factors. Aged. Carcinoma, Medullary / surgery. Carcinoma, Papillary / surgery. Female. Humans. Intraoperative Complications / prevention & control. Male. Middle Aged. Minimally Invasive Surgical Procedures. Retrospective Studies. Thyroid Diseases / surgery

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  • (PMID = 19209129.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 31
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15. Wardley AM, Hiller L, Howard HC, Dunn JA, Bowman A, Coleman RE, Fernando IN, Ritchie DM, Earl HM, Poole CJ, tAnGo Trial Collaborators: tAnGo: a randomised phase III trial of gemcitabine in paclitaxel-containing, epirubicin/cyclophosphamide-based, adjuvant chemotherapy for early breast cancer: a prospective pulmonary, cardiac and hepatic function evaluation. Br J Cancer; 2008 Aug 19;99(4):597-603
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  • Skin toxicity was assessed during radiotherapy.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Carcinoma, Ductal, Breast / drug therapy. Carcinoma, Ductal, Breast / secondary. Carcinoma, Lobular / drug therapy. Carcinoma, Lobular / secondary. Chemotherapy, Adjuvant. Cyclophosphamide / administration & dosage. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Disease-Free Survival. Epirubicin / administration & dosage. Female. Heart Function Tests. Humans. Liver Function Tests. Paclitaxel / administration & dosage. Prospective Studies. Respiratory Function Tests. Survival Rate

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  • (PMID = 18665163.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 3Z8479ZZ5X / Epirubicin; 8N3DW7272P / Cyclophosphamide; B76N6SBZ8R / gemcitabine; P88XT4IS4D / Paclitaxel
  • [Other-IDs] NLM/ PMC2527826
  • [Investigator] Howard H; Loi S; Atwal M; Foster L; McDermaid M; Pollard S; Watson C; Walker A; Parr D; Hiller L; Dunn J
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16. Quinn TR, Duncan LM, Zembowicz A, Faquin WC: Cutaneous metastases of follicular thyroid carcinoma: a report of four cases and a review of the literature. Am J Dermatopathol; 2005 Aug;27(4):306-12
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  • Sites of dermal metastases included a post-thyroidectomy scar, scalp, and sacral skin.
  • Awareness of the varied morphologies of metastatic follicular thyroid carcinoma to the skin may prompt immunohistochemical analysis and the request for a complete clinical history, ultimately preventing misdiagnosis.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Skin Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 16121050.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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17. Kurihara A, Watanabe M: Massive cutaneous metastases in the lower part of the body of a patient with rectal cancer. Dig Surg; 2009;26(4):288
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  • [MeSH-major] Adenocarcinoma / secondary. Rectal Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 19590210.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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18. Teh CL, Kuan YC, Wong JS: Systemic sclerosis in Sarawak: a profile of patients treated in the Sarawak General Hospital. Rheumatol Int; 2009 Aug;29(10):1243-5
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  • They have a mean lag time to diagnosis of 24.8 (SD 34.8) months.
  • All the patients have sclerodermatous skin changes with 16(70%) having diffuse scleroderma and 7(30%) having limited scleroderma.
  • One patient developed adenocarcinoma of the lung on follow-up.
  • This study demonstrated the rarity of systemic sclerosis in our centre with considerable lag time to diagnosis in our patients.
  • [MeSH-major] Hospitals, Public. Hypertension, Pulmonary / diagnosis. Pulmonary Fibrosis / diagnosis. Raynaud Disease / diagnosis. Scleroderma, Systemic / diagnosis. Skin Ulcer / diagnosis
  • [MeSH-minor] Age of Onset. Autoantibodies. Calcium Channel Blockers. Cross-Sectional Studies. Female. Humans. Malaysia. Male. Middle Aged. Scleroderma, Diffuse / diagnosis. Scleroderma, Limited / diagnosis


19. Cabral ES, Cassarino DS: Desmoplastic tricholemmoma of the eyelid misdiagnosed as sebaceous carcinoma: a potential diagnostic pitfall. J Cutan Pathol; 2007 Dec;34 Suppl 1:22-5
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  • Therefore, DTL should enter the differential diagnosis of clear-cell neoplasms on the eyelid.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Eyelid Neoplasms / diagnosis. Hair Diseases / diagnosis. Hair Follicle / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Glycogen / metabolism. Humans. Male. Middle Aged

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  • (PMID = 17997733.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 9005-79-2 / Glycogen
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20. Carvalho J, Fullen D, Lowe L, Su L, Ma L: The expression of CD23 in cutaneous non-lymphoid neoplasms. J Cutan Pathol; 2007 Sep;34(9):693-8
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  • In addition, CD23 reacted diffusely with cutaneous mucinous eccrine carcinoma in a manner similar to breast or colonic adenocarcinoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Receptors, IgE / metabolism. Sweat Gland Neoplasms / metabolism

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  • (PMID = 17696916.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, IgE
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21. Kondi-Pafiti A, Grapsa D, Hasiakos D, Smyrniotis V: Secondary tumors of the intestines in females: a retrospective clinicopathologic study of seven cases. Eur J Gynaecol Oncol; 2006;27(1):56-60
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  • OBJECTIVE: To investigate the primary site and the pathological features of secondary intestinal tumors in females, with emphasis on their differential diagnosis from primary neoplasms of the intestines.
  • RESULTS: The primary site of the tumor was defined as follows: the ovary (ovarian adenocarcinoma) in five cases (71.4%), the skin (cutaneous malignant melanoma) in one case (14.28%) and the uterine corpus (mixed mullerian tumor) in one case (14.28%).
  • CONCLUSION: Histological diagnosis of secondary intestinal tumors may be extremely difficult, especially when the primary site is not previously known, and because of the tendency of certain secondary tumors to mimic, both grossly and microscopically, the primary ones.
  • [MeSH-major] Adenocarcinoma / secondary. Intestinal Neoplasms / epidemiology. Intestinal Neoplasms / secondary. Melanoma / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Female. Humans. Immunohistochemistry. Incidence. Middle Aged. Neoplasms, Unknown Primary / pathology. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Prognosis. Retrospective Studies. Risk Assessment. Sampling Studies. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Uterine Neoplasms / pathology. Uterine Neoplasms / surgery

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  • (PMID = 16550971.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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22. He YF, Wang XH, Zhang GM, Chen HT, Zhang H, Feng ZH: Sustained low-level expression of interferon-gamma promotes tumor development: potential insights in tumor prevention and tumor immunotherapy. Cancer Immunol Immunother; 2005 Sep;54(9):891-7
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  • In this report, by using an ideal mouse model that expresses IFN-gamma locally in muscle, we demonstrate that sustained low-level expression of IFN-gamma promotes the development of several types of tumor including H22 hepatoma, MA782/5S mammary adenocarcinoma and B16 melanoma.
  • [MeSH-minor] Adenocarcinoma / immunology. Adenocarcinoma / metabolism. Adenocarcinoma / prevention & control. Animals. Antigens, CD. Antigens, CD274. Antigens, CD80 / metabolism. Antigens, Differentiation / metabolism. CTLA-4 Antigen. DNA-Binding Proteins / metabolism. Female. Forkhead Transcription Factors. Liver Neoplasms / immunology. Liver Neoplasms / metabolism. Liver Neoplasms / prevention & control. Membrane Glycoproteins / metabolism. Mice. Mice, Inbred BALB C. Muscles / immunology. Muscles / metabolism. Peptides / metabolism. Programmed Cell Death 1 Ligand 2 Protein. Skin Neoplasms / immunology. Skin Neoplasms / metabolism. Skin Neoplasms / prevention & control. T-Lymphocytes, Cytotoxic. Tumor Cells, Cultured

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  • (PMID = 15776283.001).
  • [ISSN] 0340-7004
  • [Journal-full-title] Cancer immunology, immunotherapy : CII
  • [ISO-abbreviation] Cancer Immunol. Immunother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / Antigens, CD80; 0 / Antigens, Differentiation; 0 / Antineoplastic Agents; 0 / CTLA-4 Antigen; 0 / Cd274 protein, mouse; 0 / Ctla4 protein, mouse; 0 / DNA-Binding Proteins; 0 / Forkhead Transcription Factors; 0 / Foxp3 protein, mouse; 0 / Membrane Glycoproteins; 0 / Pdcd1lg2 protein, mouse; 0 / Peptides; 0 / Programmed Cell Death 1 Ligand 2 Protein; 82115-62-6 / Interferon-gamma
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23. Graeven U, Kremer B, Südhoff T, Killing B, Rojo F, Weber D, Tillner J, Unal C, Schmiegel W: Phase I study of the humanised anti-EGFR monoclonal antibody matuzumab (EMD 72000) combined with gemcitabine in advanced pancreatic cancer. Br J Cancer; 2006 May 8;94(9):1293-9
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  • Three groups of chemotherapy-naive advanced pancreatic adenocarcinoma patients (n=17) received escalating doses of matuzumab (400 mg weekly, 800 mg biweekly, or 800 mg weekly) and gemcitabine (1000 mg m-2 weekly in weeks 1-3 of each 4-week cycle).
  • Toxicity, antitumour activity, pharmacokinetic (PK) parameters, and pharmacodynamic (PD) markers in skin biopsies were evaluated.
  • Common study drug-related adverse events were skin toxicities (grade 2=6, grade 1=7) and fever (grade 1=4).
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Pancreatic Neoplasms / drug therapy

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  • (PMID = 16622465.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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24. Kundranda MN, Daw AH: Sister Mary Joseph nodule: an important sign of an ominous diagnosis. Intern Med J; 2006 Sep;36(9):617
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  • [Title] Sister Mary Joseph nodule: an important sign of an ominous diagnosis.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Adenocarcinoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Humans. Male

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  • (PMID = 16911556.001).
  • [ISSN] 1445-5994
  • [Journal-full-title] Internal medicine journal
  • [ISO-abbreviation] Intern Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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25. Fernandez-Flores A, Pol A, Juanes F, Crespo LG: Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies. Med Mol Morphol; 2007 Dec;40(4):212-7
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  • The patient did not present any symptoms, and the only complaint was the nodule, which was resected for diagnosis.
  • In spite of these characteristics, which are, for some authors, indicative of an apocrine phenotype, the immunohistochemical study revealed some differences with the profile that has been described in cases of apocrine adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / immunology. Adenocarcinoma / pathology. Antibodies, Neoplasm / immunology. Skin Neoplasms / immunology. Skin Neoplasms / pathology


26. Sezen OS, Eraslan G, Coskuner T, Yavuzer D, Bilici A, Bilge S, Keser SH, Gumus M, Unver S: Endometrial adenocarcinoma metastasis to nasal skin. J Otolaryngol Head Neck Surg; 2010 Apr;39(2):E8-11
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  • [Title] Endometrial adenocarcinoma metastasis to nasal skin.
  • [MeSH-major] Adenocarcinoma / secondary. Endometrial Neoplasms / pathology. Nose Neoplasms / secondary. Skin Neoplasms / secondary

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  • (PMID = 20211093.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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27. Hanson RP, Kneafsey B, Royston D: Cutaneous lesions, not just skin deep! Ir J Med Sci; 2006 Jan-Mar;175(1):66-8
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  • [Title] Cutaneous lesions, not just skin deep!
  • The growth pattern of skin metastases is unpredictable and may differ from that of the primary tumour.
  • Skin metastases may present as rapidly growing, solitary sessile or polypoid vascular nodules that ulcerate or bleed.
  • METHODS: We present three cases of metastatic skin cancer recently seen in our Department and review the clinical and pathological findings.
  • RESULTS: The finding of metastatic skin cancer is associated with a very poor prognosis and suggests widespread disease dissemination.
  • CONCLUSION: The paper emphasizes the importance of excisional biopsy and accurate tissue diagnosis of skin nodules.
  • [MeSH-major] Neoplasm Metastasis / diagnosis. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Aged. Carcinoma / diagnosis. Carcinoma / secondary. Carcinoma, Renal Cell / pathology. Female. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Lung Neoplasms / pathology. Male. Middle Aged. Uterine Neoplasms / pathology

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  • (PMID = 16615234.001).
  • [ISSN] 0021-1265
  • [Journal-full-title] Irish journal of medical science
  • [ISO-abbreviation] Ir J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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28. Lim C, Chan R, Regan W: Renal cell carcinoma with cutaneous metastases. Australas J Dermatol; 2005 Aug;46(3):158-60
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  • It shows that a high index of suspicion should be maintained as cutaneous metastases can mimic other skin conditions.
  • [MeSH-major] Adenocarcinoma, Clear Cell / secondary. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Ear Neoplasms / diagnosis. Ear Neoplasms / secondary. Ear Neoplasms / therapy. Facial Neoplasms / diagnosis. Facial Neoplasms / secondary. Facial Neoplasms / therapy. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / secondary. Head and Neck Neoplasms / therapy. Humans. Lip Neoplasms / diagnosis. Lip Neoplasms / secondary. Lip Neoplasms / therapy. Male. Nephrectomy. Treatment Outcome

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  • (PMID = 16008646.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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29. Pinson PJ, Griep C, Sanders WH, Lelie B: [Myositis as a 'radiation-recall phenomenon' following palliative chemotherapy with carboplatin-gemcitabin for non-small-cell pulmonary carcinoma]. Ned Tijdschr Geneeskd; 2006 Aug 26;150(34):1891-4
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  • A 58-year-old woman suffered pain due to a stage-IV adenocarcinoma of the right upper-lung lobe with signs of growth into the right axilla.
  • She was diagnosed with myositis as a delayed reaction to irradiation (radiation-recall phenomenon) based on the clinical symptoms (redness of the skin, pain and distinct swelling) but especially on the basis of a CT-scan.
  • The possibility of myositis as a radiation-recall phenomenon should be borne in mind whenever a patient presents with skin changes or pain within a previous irradiation field during chemotherapy with, for example, gemcitabin.

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  • (PMID = 16970014.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Radiation-Sensitizing Agents; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; BG3F62OND5 / Carboplatin
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30. Arat YO, Boniuk M: Red lesions of the iris, choroid, and skin secondary to metastatic carcinoma of the thyroid: a review. Surv Ophthalmol; 2007 Sep-Oct;52(5):523-8
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  • [Title] Red lesions of the iris, choroid, and skin secondary to metastatic carcinoma of the thyroid: a review.
  • An excisional biopsy of the skin lesion was performed.
  • A diagnosis of metastatic follicular thyroid carcinoma was made according to the histopathologic findings and immunohistochemistry.
  • Ocular and skin metastasis secondary to thyroid carcinoma is uncommon.
  • Although ocular and skin metastases from thyroid carcinoma are rare, this possibility should be considered in the differential diagnosis of reddish-colored iris and choroidal masses as well as reddish nodular lesions of the scalp, face, and neck.
  • [MeSH-major] Adenocarcinoma, Follicular / secondary. Choroid Neoplasms / secondary. Iris Neoplasms / secondary. Skin Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 17719373.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Iodine Radioisotopes; 0 / Neoplasm Proteins
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31. András C, Ponyi A, Constantin T, Csiki Z, Szekanecz E, Szodoray P, Dankó K: Dermatomyositis and polymyositis associated with malignancy: a 21-year retrospective study. J Rheumatol; 2008 Mar;35(3):438-44
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  • The highest probability for tumor recognition was before 2 years and after 3 years of the diagnosis of myositis (28 cancer-associated myositis): most frequent was breast tumor, and adenocarcinoma was the predominant histological type.
  • The skin lesions and diaphragmatic involvement were more severe; distal muscle weakness was conventional, along with proximal muscle weakness and frequent immobility.

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  • (PMID = 18203322.001).
  • [ISSN] 0315-162X
  • [Journal-full-title] The Journal of rheumatology
  • [ISO-abbreviation] J. Rheumatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / HLA-DR Antigens; 0 / HLA-DRB1 Chains; 0 / HLA-DRB1*03:01 antigen
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32. Aldewereld W, Blanken R: [Extra-mammary Paget's disease of the scrotum]. Ned Tijdschr Geneeskd; 2009;153:A919
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  • The diagnosis of extra-mammary Paget's disease (EMPD) was made.
  • EMPD is an intra-epidermal adenocarcinoma, found in areas with apocrine sweat glands.
  • In secondary EMPD (25%) there is epidermal invasion of malignant cells of skin adnexal adenocarcinomas, or there is an association with adenocarcinomas of nearby internal organs.
  • [MeSH-major] Genital Neoplasms, Male / diagnosis. Paget Disease, Extramammary / diagnosis. Scrotum / pathology

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  • (PMID = 20051181.001).
  • [ISSN] 1876-8784
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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33. Obaidat NA, Awamleh AA, Ghazarian DM: Adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma of the peri-anal region. Eur J Dermatol; 2006 Sep-Oct;16(5):576-8
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  • [Title] Adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma of the peri-anal region.
  • We report the case of a 67-year-old woman who presented with a peri-anal skin tag.
  • To the best of our knowledge, this is the first description of a peri-anal adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17101482.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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34. Oudidi A, El-Alami MN, Boulaich M, Jazouli N, Kzadri M: [Primary sub-mandibular gland tumours: experience based on 68 cases]. Rev Laryngol Otol Rhinol (Bord); 2006;127(3):187-90
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  • Clinical suspicion of malignancy was associated with symptom of pain, cervical adenopathy, nerve palsy, skin and/or bone invasion.
  • Definitive diagnosis was by complete excision and pathological examination.
  • For malignant lesions (n= 31) the most frequent were: Adenoid cystic carcinoma (n= 10), epidermoid carcinoma (n= 5), adenocarcinoma (n= 5), mucoepidermoid carcinoma (n= 3), malignant non Hodgkinien lymphoma (n= 5).
  • Any delay in diagnosis or inappropriate management may result in a poor prognosis for the patient.
  • [MeSH-major] Submandibular Gland Neoplasms / classification. Submandibular Gland Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Early Diagnosis. Female. Humans. Male. Middle Aged. Prognosis

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  • (PMID = 17007195.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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35. Früh M, Ruhstaller T, Neuweiler J, Cerny T: Resection of skin metastases from gastric carcinoma with long-term follow-up: an unusual clinical presentation. Onkologie; 2005 Jan;28(1):38-40
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  • [Title] Resection of skin metastases from gastric carcinoma with long-term follow-up: an unusual clinical presentation.
  • BACKGROUND: Skin metastases from gastric cancer are rare and generally occur at a very late stage in the course of the disease.
  • CASE REPORT: A 60-year-old patient with localized adenocarcinoma of the cardia (stage II) was primarily treated with extended total gastrectomy with transhiatal resection of the distal esophagus.
  • 6 isolated skin metastases occurred on the head and on the thigh 2 years later.
  • Morphologically and according to an extensive immunohistochemical comparison the skin lesions and the primary tumor were identical.
  • The patient presented with dysphagia more than 6 years after the primary diagnosis, and a local recurrence was diagnosed.
  • This patient remains free of symptoms and is clinically in complete remission 7.5 years after the primary diagnosis.
  • Usually the prognosis after occurrence of metastases to the skin is poor, but long-term survival after systemic therapy has been reported.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Skin Neoplasms / secondary. Skin Neoplasms / surgery. Stomach Neoplasms / surgery

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  • (PMID = 15604627.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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36. Neyns B, Aerts M, Van Nieuwenhove Y, Fontaine C, De Coster L, Schallier D, Vanderauwera J, De Munck F, Vandenbroucke F, Everaert H, Meert V, De Mey J, De Ridder M, Delvaux G, De Grève J: Cetuximab with hepatic arterial infusion of chemotherapy for the treatment of colorectal cancer liver metastases. Anticancer Res; 2008 Jul-Aug;28(4C):2459-67
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  • Adverse events: repeated grade 3 skin toxicity (1 pt), abdominal pain with elevated liver enzymes and asthenia (2 pts), duodenal ulcer (2 pts) with catheter migration and intestinal bleeding (1 pt), reversible interstitial pneumonitis (1 pt), and cystic bile duct dilatation (2 pts) with arteriobiliary fistulisation (1 pt).
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antibodies, Monoclonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Colorectal Neoplasms / drug therapy. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary

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  • (PMID = 18751435.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; PQX0D8J21J / Cetuximab; U3P01618RT / Fluorouracil
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37. Fukui T, Otani S, Hataishi R, Jiang SX, Nishii Y, Igawa S, Mitsufuji H, Kubota M, Katagiri M, Masuda N: Successful rechallenge with erlotinib in a patient with EGFR-mutant lung adenocarcinoma who developed gefitinib-related interstitial lung disease. Cancer Chemother Pharmacol; 2010 Mar;65(4):803-6
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  • [Title] Successful rechallenge with erlotinib in a patient with EGFR-mutant lung adenocarcinoma who developed gefitinib-related interstitial lung disease.
  • Although the most common adverse events are skin rash and diarrhea, the most serious adverse effect reported is drug-related interstitial lung disease (ILD) (Inoue et al. in Lancet 361:137-139, 2003; Ando et al. in J Clin Oncol 24:2549-2556, 2006).
  • [MeSH-major] Adenocarcinoma / drug therapy. Lung Diseases, Interstitial / drug therapy. Lung Neoplasms / drug therapy. Mutation. Quinazolines / therapeutic use. Receptor, Epidermal Growth Factor / genetics


38. Berndt U, Philipsen L, Bartsch S, Hu Y, Röcken C, Bertram W, Hämmerle M, Rösch T, Sturm A: Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinoma. Mol Cancer; 2010;9:177
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  • [Title] Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinoma.
  • BACKGROUND: Barrett's esophagus (BE) is caused by gastroesophageal reflux with consecutive mucosal inflammation, predisposing patients to the development of esophageal adenocarcinoma (EAC).
  • [MeSH-major] Adenocarcinoma / immunology. Barrett Esophagus / immunology. Epitopes / analysis. Esophageal Neoplasms / immunology

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  • (PMID = 20604962.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Epitopes; 0 / Ligands
  • [Other-IDs] NLM/ PMC2909181
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39. Lange TS, Kim KK, Singh RK, Strongin RM, McCourt CK, Brard L: Iron(III)-salophene: an organometallic compound with selective cytotoxic and anti-proliferative properties in platinum-resistant ovarian cancer cells. PLoS One; 2008 May 28;3(5):e2303
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  • METHODOLOGY/PRINCIPAL FINDINGS: Fe-SP displayed selective cytotoxicity against SKOV-3 and OVCAR-3 (ovarian epithelial adenocarcinoma) cell lines at concentrations between 100 nM and 1 microM, while the viability of HeLa cells (epithelial cervix adenocarcinoma) or primary lung or skin fibroblasts was not affected.

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  • [ErratumIn] PLoS ONE. 2008;3(7). doi: 10.1371/annotation/d97d24fc-aa07-40fd-88b2-6b2e050ddb31
  • (PMID = 18509533.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / K12 HD043447; United States / NCRR NIH HHS / RR / P20 RR018728; United States / NCRR NIH HHS / RR / 1-P20RR018728
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Ferric Compounds; 0 / Iron(III)-salophene; 49DFR088MY / Platinum
  • [Other-IDs] NLM/ PMC2386551
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40. Nolan L, Eccles D, Cross E, Crawford G, Beck N, Bateman A, Ottensmeier C: First case report of Muir-Torre syndrome associated with non-small cell lung cancer. Fam Cancer; 2009;8(4):359-62
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  • The eponymous Muir-Torre syndrome (MTS) is a clinical variant of hereditary non polyposis colorectal cancer, and is defined as an autosomal dominant condition with simultaneous sebaceous neoplasms of the skin and visceral malignant disease resulting from germline mutations in the DNA mismatch repair (MMR) genes.
  • Here we report the first recorded case of adenocarcinoma of the lung with loss of MMR gene function to be identified in a patient with MTS.
  • The MMR deficient lung tumour demonstrated less aggressive clinical behaviour compared with a synchronous MMR proficient lung adenocarcinoma.


41. Schütte W, Nagel S, Schaedlich S, Brust D, Blankenburg T: Clinical benefit in NSCLC: advanced-stage patients require symptom-improving palliation. Experiences from the 'Iressa' expanded access program. Onkologie; 2005 Apr;28(4):195-8
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  • Adenocarcinoma histology and former nicotine abstention seem to favor sensitivity to gefitinib.
  • CTC grade 3/4 toxicities were observed in only one patient in form of skin reactions.

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  • (PMID = 15840967.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Quinazolines; S65743JHBS / gefitinib
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42. Colla TG, Lovatto L, Duquia RP: Case for diagnosis: umbilical metastasis of pancreatic carcinoma (Sister Mary Joseph's Nodule). An Bras Dermatol; 2009 Jul;84(3):297-8
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  • [Title] Case for diagnosis: umbilical metastasis of pancreatic carcinoma (Sister Mary Joseph's Nodule).
  • Histologic examination demonstrated poorly differentiated adenocarcinoma.
  • Abdominal tomography showed advanced pancreatic cancer with metastatic involvement of the liver and the diagnosis of pancreatic adenocarcinoma with umbilical metastasis -- Sister Mary Joseph's nodule.
  • [MeSH-major] Adenocarcinoma / secondary. Pancreatic Neoplasms / pathology. Skin Neoplasms / secondary. Umbilicus / pathology

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  • (PMID = 19668947.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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43. Chen CW, Wang WM, Su YC, Wu JY, Hsieh JS, Wang JY: Oxaliplatin/5-fluorouracil/leucovorin (FOLFOX4) regimen as an adjuvant chemotherapy in the treatment of advanced jejunal adenocarcinoma: a report of 2 cases. Med Princ Pract; 2008;17(6):496-9
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  • [Title] Oxaliplatin/5-fluorouracil/leucovorin (FOLFOX4) regimen as an adjuvant chemotherapy in the treatment of advanced jejunal adenocarcinoma: a report of 2 cases.
  • OBJECTIVE: To present our clinical experience of 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX4) regimen administered as an adjuvant chemotherapy to 2 patients with advanced jejunal adenocarcinoma.
  • The patient then underwent an exploratory laparotomy and the jejunal adenocarcinoma with localized peritoneal metastasis was found (R0 resection, T3N1M1, stage IV).
  • Surgical exploration revealed a proximal jejunal adenocarcinoma with regional lymph node involvement (R0 resection, T3N1M0, stage III).
  • No obvious toxicity developed except for temporary grade I peripheral neuropathy and skin eruption.
  • CONCLUSION: This report showed that adjuvant chemotherapy with FOLFOX4 regimen seems effective and well tolerated in these 2 patients with advanced jejunal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Jejunal Neoplasms / drug therapy

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18836281.001).
  • [ISSN] 1423-0151
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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44. Sztanke K, Rzymowska J, Niemczyk M, Dybała I, Kozioł AE: Synthesis, crystal structure and anticancer activity of novel derivatives of ethyl 1-(4-oxo-8-aryl-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazin-3-yl)formate. Eur J Med Chem; 2006 Apr;41(4):539-47
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  • Compounds 10 and 11 exhibited anticancer activity towards following cancer cells: LS180 (ECACC 87021202, human Caucasian colon adenocarcinoma cells), SiHa (ECACC 85060701, uterus cancer cells), T47D (ECACC 85102201, human breast carcinoma cells).
  • Moreover, the distinctly marked lower cytotoxicity of tested compounds against normal cell lines (HSF, human skin fibroblast cells and Vero African Green Monkey Kidney cells, GMK clone) and almost two-times higher against cancer cell lines was confirmed.

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  • (PMID = 16545495.001).
  • [ISSN] 0223-5234
  • [Journal-full-title] European journal of medicinal chemistry
  • [ISO-abbreviation] Eur J Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Antifungal Agents; 0 / Antineoplastic Agents; 0 / Formates; 0 / Indicators and Reagents; 0 / Triazines; 0 / ethyl 1-(4-oxo-8-aryl-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazin-3-yl)formate
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45. Poonawalla T, Diwan H, Duvic M: Mycosis fungoides with coccidioidomycosis. Clin Lymphoma Myeloma; 2006 Sep;7(2):148-50
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  • We present a patient with mycosis fungoides and infection with Coccidioides immitis of the skin, which has not been previously reported.
  • [MeSH-major] Adenocarcinoma / complications. Coccidioidomycosis / complications. Lung Neoplasms / complications. Mycosis Fungoides / complications. Neoplasms, Second Primary / complications. Skin Neoplasms / complications


46. Olsen CC, Schefter TE, Chen H, Kane M, Leong S, McCarter MD, Chen Y, Mack P, Eckhardt SG, Stiegmann G, Raben D: Results of a phase I trial of 12 patients with locally advanced pancreatic carcinoma combining gefitinib, paclitaxel, and 3-dimensional conformal radiation: report of toxicity and evaluation of circulating K-ras as a potential biomarker of response to therapy. Am J Clin Oncol; 2009 Apr;32(2):115-21
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  • OBJECTIVE: To evaluate the toxicity of daily gefitinib, an epidermal growth factor receptor-tyrosine kinase inhibitor, with concurrent chemoradiation (CRT) in patients with locally advanced pancreatic adenocarcinoma and prospectively evaluate plasma k-ras as a potential marker of response to gefitinib and CRT.
  • RESULTS: Common adverse events included grade 1 skin rash (63%), grade 1 to 2 gastrointestinal symptoms including anorexia, nausea, vomiting, and diarrhea occurred in 63% of patients, grade 3 nausea occurred in 45% of patients.
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / pathology. Adenocarcinoma / therapy. Aged. Combined Modality Therapy. DNA Mutational Analysis. Female. Humans. Imaging, Three-Dimensional. Male. Middle Aged. Neoplasm Staging. Paclitaxel / administration & dosage. Polymerase Chain Reaction. Polymorphism, Restriction Fragment Length. Prognosis. Prospective Studies. Quinazolines / administration & dosage. Survival Rate

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  • (PMID = 19307945.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; 0 / Quinazolines; EC 3.6.5.2 / ras Proteins; P88XT4IS4D / Paclitaxel; S65743JHBS / gefitinib
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47. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. Int J Toxicol; 2007;26 Suppl 1:3-106
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  • Capsicum-derived ingredients function as skin-conditioning agents--miscellaneous, external analgesics, flavoring agents, or fragrance components in cosmetics.
  • A rabbit skin irritation test of Capsicum Annuum Fruit Extract at concentrations ranging from 0.1% to 1.0% produced no irritation, but Capsicum Frutescens Fruit Extract induced concentration-dependent (at 25 to 500 microg/ml) cytotoxicity in a human buccal mucosa fibroblast cell line.
  • Adenocarcinoma of the abdomen was observed in 7/20 mice fed 100 mg red chilies per day for 12 months; no tumors were seen in control animals.
  • Capsaicin functions as an external analgesic, a fragrance ingredient, and as a skin-conditioning agent--miscellaneous in cosmetic products, but is not in current use.
  • In vitro percutaneous absorption of Capsaicin has been demonstrated in human, rat, mouse, rabbit, and pig skin.
  • Enhancement of the skin permeation of naproxen (nonsteroidal anti-inflammatory agent) in the presence of Capsaicin has also been demonstrated.
  • The results of provocative and predictive tests involving human subjects indicated that Capsaicin is a skin irritant.
  • Skin irritation and other tumor-promoting effects of Capsaicin appear to be mediated through interaction with the same vanilloid receptor.
  • Given this mechanism of action and the observation that many tumor promoters are irritating to the skin, the Panel considered it likely that a potent tumor promoter may also be a moderate to severe skin irritant.
  • Thus, a limitation on Capsaicin content that would significantly reduce its skin irritation potential is expected to, in effect, lessen any concerns relating to tumor promotion potential.
  • Because Capsaicin enhanced the penetration of an anti-inflammatory agent through human skin, the Panel recommends that care should be exercised in using ingredients that contain Capsaicin in cosmetic products.

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  • (PMID = 17365137.001).
  • [ISSN] 1091-5818
  • [Journal-full-title] International journal of toxicology
  • [ISO-abbreviation] Int. J. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cosmetics; 0 / Plant Extracts; 0 / Resins, Plant; S07O44R1ZM / Capsaicin
  • [Number-of-references] 462
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48. Closmann JJ, Torske KR: When a mucocele is not a mucocele: adenocarcinoma NOS--a case report and review of the literature. Gen Dent; 2007 Jul-Aug;55(4):325-7
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  • [Title] When a mucocele is not a mucocele: adenocarcinoma NOS--a case report and review of the literature.
  • Adenocarcinoma not otherwise specified (NOS) is a rare lesion of the salivary glands that can resemble a mucocele.
  • [MeSH-major] Adenocarcinoma / pathology. Mucocele / diagnosis. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adult. Carcinoma, Skin Appendage / diagnosis. Diagnosis, Differential. Humans. Male

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  • (PMID = 17682642.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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49. Hanaoka T, Sone S, Yamaguchi S, Okada M, Hayano T: [An octogenarian case of postoperative recurrent lung cancer responding to treatments with radiation plus gefitinib]. Gan To Kagaku Ryoho; 2007 Oct;34(10):1701-3
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  • Without harmful phenomena except skin eruptions, her quality of life was good with a performance status (PS) 0 at 85 years 4 months of age, 9 years 2 months after the resection, with 2 years 5 months of gefitinib administration.
  • [MeSH-major] Adenocarcinoma / therapy. Antineoplastic Agents / therapeutic use. Lung Neoplasms / therapy. Quinazolines / therapeutic use

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  • (PMID = 17940395.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Quinazolines; S65743JHBS / gefitinib
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50. Pushkar A, Khan L, Singh P, Agarwal A: Cutaneous metastasis from visceral malignancy: A rare presentation. J Cytol; 2009 Jul;26(3):109-10
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  • Here we report two cases of carcinoma gall bladder that presented with skin nodule.
  • Fine needle aspiration cytology of these nodules revealed metastatic deposits of adenocarcinoma and was instrumental in establishing the primaries.

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  • [Cites] South Med J. 2003 Feb;96(2):164-7 [12630642.001]
  • [Cites] Am J Surg. 1961 Jul;102:90-3 [13777392.001]
  • [Cites] Int J Dermatol. 1995 May;34(5):360-2 [7607800.001]
  • [Cites] Arch Dermatol. 1972 Jun;105(6):862-8 [5030236.001]
  • [Cites] Ann Surg. 1950 Jul;132(1):121-8 [15426196.001]
  • (PMID = 21938168.001).
  • [ISSN] 0970-9371
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3168011
  • [Keywords] NOTNLM ; Carcinoma gall bladder / cutaneous metastasis / periodic acid Schiff stain
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51. Laugier C: [Taking care of a patient presenting with enterocutaneous fistulas, a real challenge]. Soins; 2008 Sep;(728):49-50
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  • [MeSH-major] Ileostomy / adverse effects. Intestinal Fistula / nursing. Postoperative Care / methods. Skin Care / methods
  • [MeSH-minor] Adenocarcinoma / surgery. Drainage / instrumentation. Drainage / nursing. Gastrectomy / adverse effects. Humans. Male. Stomach Neoplasms / surgery

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  • (PMID = 18972819.001).
  • [ISSN] 0038-0814
  • [Journal-full-title] Soins; la revue de référence infirmière
  • [ISO-abbreviation] Soins
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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52. Cidon EU: Cutaneous metastases in 42 patients with cancer. Indian J Dermatol Venereol Leprol; 2010 Jul-Aug;76(4):409-12
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  • [MeSH-major] Melanoma / epidemiology. Melanoma / secondary. Skin Neoplasms / epidemiology. Skin Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / secondary. Adult. Aged. Breast Neoplasms / epidemiology. Breast Neoplasms / pathology. Female. Gastrointestinal Neoplasms / epidemiology. Gastrointestinal Neoplasms / pathology. Humans. Incidence. Male. Middle Aged. Prognosis

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  • (PMID = 20657126.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] India
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53. Kavgaci H, Reis A, Ozdemir F, Bektas O, Arslan M, Aydin F: Carcinoma erysipelatoides resulting from gastric adenocarcinoma: an unusual clinical presentation. Med Princ Pract; 2005 Jan-Feb;14(1):61-3
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  • [Title] Carcinoma erysipelatoides resulting from gastric adenocarcinoma: an unusual clinical presentation.
  • OBJECTIVE: To report a rare case of carcinoma erysipelatoides on the laryngeal skin caused by stomach adenocarcinoma.
  • CLINICAL PRESENTATION AND INTERVENTION: A 48-year-old male, who had undergone a gastrectomy 18 months prior to admission for stage IIIA gastric adenocarcinoma, presented with a reddish induration of the cervical skin, lymphadenopathy in both supraclavicular areas and widespread subcutaneous nodules.
  • CONCLUSION: We recommend combination chemotherapy in patients with cutaneous metastasis of gastric adenocarcinoma as a safe and effective treatment.
  • [MeSH-major] Adenocarcinoma / secondary. Head and Neck Neoplasms / secondary. Skin Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 15608485.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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54. Biglioli F, Autelitano L: Reconstruction after total parotidectomy using a de-epithelialized free flap. J Craniomaxillofac Surg; 2007 Dec;35(8):364-8
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  • PATIENTS: Two patients underwent total parotidectomy because of recurrent sialoadenolithiasis in one case and for adenocarcinoma in the other.
  • [MeSH-minor] Adenocarcinoma / surgery. Aged. Esthetics. Female. Humans. Male. Middle Aged. Parotid Diseases / surgery. Parotid Neoplasms / surgery. Salivary Duct Calculi / surgery. Skin Transplantation / methods. Subcutaneous Fat / transplantation. Sweating, Gustatory / prevention & control

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  • (PMID = 17954031.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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55. Grande M, Facchini F, La Rosa M, Pozzoli GL, Leone M, Piana S, Monica B: [Carcinoma of the collecting ducts of Bellini: a case report with cutaneous metastasis as the initial clinical manifestation]. Urologia; 2010 Jan-Mar;77 Suppl 16:51-4
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  • INTRODUCTION: Bellini's collecting ducts carcinoma represents a rare tumor with an aggressive behaviour with a poor prognosis and often metastatic at diagnosis.
  • RESULTS: After reporting an histopathologic finding of cutaneous metastasis of unknown origin adenocarcinoma with poorly differentiation, a voluminous 6 cm left mesorenal mass is diagnosed through uro-CT.
  • The histopathologic diagnosis reported was Bellini tumor at stage pT3a-N2-M1.
  • It has not reported significative responsiveness to adjuvant chemotherapy and the patient was died seven months after diagnosis of cutaneous metastasis.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / diagnosis. Skin Neoplasms / secondary

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  • (PMID = 21104663.001).
  • [ISSN] 1724-6075
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Damm DD, Roddy SC, White DK: Diffuse oral papillomatosis with corrugated lesions of skin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Nov;106(5):630-6
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  • [Title] Diffuse oral papillomatosis with corrugated lesions of skin.
  • [MeSH-minor] Adenocarcinoma / complications. Aged, 80 and over. Diagnosis, Differential. Endometrial Neoplasms / complications. Fatal Outcome. Female. Humans. Papilloma / pathology

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  • (PMID = 18701323.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Conference; Journal Article
  • [Publication-country] United States
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57. Wietfeldt ED, Thiele J: Malignancies of the anal margin and perianal skin. Clin Colon Rectal Surg; 2009 May;22(2):127-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignancies of the anal margin and perianal skin.
  • Malignancies of the anal margin and perianal skin are relatively uncommon lesions, comprising 3 to 4% of all anorectal malignancies.
  • Commonly included in this group of cancers are Bowen's disease (intraepithelial squamous cell cancer), perianal Paget's disease (intraepithelial adenocarcinoma), invasive squamous cell cancer, basal cell cancer, and malignant melanoma.
  • Proper diagnosis requires a high index of suspicion on the part of the surgeon.
  • Innocent local irritations will resolve in a short time with appropriate therapy; those that persist must be biopsied for tissue diagnosis.

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  • [Cites] Dis Colon Rectum. 2008 Dec;51(12):1842-5 [18584248.001]
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  • (PMID = 20436838.001).
  • [ISSN] 1530-9681
  • [Journal-full-title] Clinics in colon and rectal surgery
  • [ISO-abbreviation] Clin Colon Rectal Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780245
  • [Keywords] NOTNLM ; Anal margin cancer / diagnosis / local excision / radiation therapy / treatment options
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58. Wiksell H, Schässburger KU, Janicijevic M, Leifland K, Löfgren L, Rotstein S, Sandberg PO, Wadström C, Auer G: Prevention of tumour cell dissemination in diagnostic needle procedures. Br J Cancer; 2010 Nov 23;103(11):1706-9
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  • Routine FNAB was performed in 88 patients with adenocarcinoma and blood droplets passing the skin orifice were cytomorphologically analysed for the presence of tumour cells.
  • In all 31 patients blood passing the skin orifice was sparse.

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  • (PMID = 21045831.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2994228
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59. Ferrand N, Atfi A, Prunier C: The oncoprotein c-ski functions as a direct antagonist of the transforming growth factor-{beta} type I receptor. Cancer Res; 2010 Nov 1;70(21):8457-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / metabolism. Breast Neoplasms / metabolism. DNA-Binding Proteins / physiology. Lung Neoplasms / metabolism. Melanoma / metabolism. Protein-Serine-Threonine Kinases / antagonists & inhibitors. Proto-Oncogene Proteins / physiology. Receptors, Transforming Growth Factor beta / antagonists & inhibitors
  • [MeSH-minor] Cell Nucleus / metabolism. Cytoplasm / metabolism. Female. Humans. Immunoenzyme Techniques. Intracellular Signaling Peptides and Proteins / metabolism. Phosphorylation. Protein Transport. Signal Transduction. Skin / metabolism. Skin / pathology. Smad Proteins, Receptor-Regulated / metabolism. Smad2 Protein / metabolism. Smad3 Protein / metabolism. Tissue Array Analysis. Transforming Growth Factor beta / metabolism. Tumor Cells, Cultured

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  • [Copyright] ©2010 AACR.
  • (PMID = 20959473.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Proto-Oncogene Proteins; 0 / Receptors, Transforming Growth Factor beta; 0 / SKIL protein, human; 0 / Smad Proteins, Receptor-Regulated; 0 / Smad2 Protein; 0 / Smad3 Protein; 0 / Transforming Growth Factor beta; 126648-96-2 / SKI protein, human; EC 2.7.1.11 / TGF-beta type I receptor; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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60. Fessa CK, Sharma R, Fernández-Peñas P: Cutaneous epithelioid angiosarcoma occurring at a peristomal site. J Am Acad Dermatol; 2010 Aug;63(2):e55-6
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  • [MeSH-major] Colostomy. Hemangiosarcoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / surgery. Aged. Biopsy. Female. Humans. Rectal Neoplasms / surgery

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  • (PMID = 20633792.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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61. Kleikamp S, Böhm M, Frosch P, Brinkmeier T: [Acanthosis nigricans, papillomatosis mucosae and "tripe palms" in a patient with metastasized gastric carcinoma]. Dtsch Med Wochenschr; 2006 May 26;131(21):1209-13
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  • HISTORY AND CLINICAL FINDINGS: A 48-year-old obese man presented with thickening, coarseness and hyperpigmentation of the skin, especially of the intertriginous areas, papillomatous to verrucous lesions of the lips and buccal oral mucosa, and hyperkeratosis of the palms ("tripe palms") and soles.
  • EXAMINATIONS: Immunohistochemical studies of the skin lesion revealed increased epidermal immunoreactivity for the melanocortin-1-receptor.
  • Gastroscopic findings were suspicious of adenocarcinoma of the stomach: it was classified histologically as a signet-ring cell, non-mucinous adenocarcinoma.
  • At the time of diagnosis the tumor had already metastasized to perigastric and peripancreatic lymph nodes with peritoneal carcinosis.
  • A pathogenetic role of a-melanocyte-stimulating hormone in the development of the skin changes is suggested.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / secondary. Skin Diseases / etiology. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology
  • [MeSH-minor] Acanthosis Nigricans / diagnosis. Acanthosis Nigricans / etiology. Antigens, Tumor-Associated, Carbohydrate / blood. Biomarkers, Tumor / blood. CA-19-9 Antigen / blood. Carcinoembryonic Antigen / blood. Fatal Outcome. Humans. Immunohistochemistry. Keratoderma, Palmoplantar / diagnosis. Keratoderma, Palmoplantar / etiology. Lymphatic Metastasis. Male. Middle Aged. Mouth Neoplasms / diagnosis. Mouth Neoplasms / etiology. Obesity / complications. Papilloma / diagnosis. Papilloma / etiology. Peritoneal Neoplasms / secondary. Receptor, Melanocortin, Type 1 / analysis

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  • (PMID = 16721709.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / CA-72-4 antigen; 0 / Carcinoembryonic Antigen; 0 / Receptor, Melanocortin, Type 1
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62. Guldbakke KK, Schanbacher CF: Disseminated intravascular coagulation unmasked by Mohs micrographic surgery. Dermatol Surg; 2006 May;32(5):760-4
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  • [MeSH-major] Adenocarcinoma / epidemiology. Carcinoma, Basal Cell / epidemiology. Disseminated Intravascular Coagulation / diagnosis. Disseminated Intravascular Coagulation / epidemiology. Incidental Findings. Mohs Surgery. Postoperative Hemorrhage / etiology. Prostatic Neoplasms / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 16706778.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antifibrinolytic Agents; U6F3787206 / Aminocaproic Acid
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63. Rodriguez-Blanco I, Ginarte Val M, Peteiro C, Toribio J: Multiple atypical naevi after systemic 5-fluorouracil. J Eur Acad Dermatol Venereol; 2007 Jul;21(6):823-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Fluorouracil / adverse effects. Nevus, Pigmented / chemically induced. Skin Neoplasms / chemically induced
  • [MeSH-minor] Adenocarcinoma / drug therapy. Aged. Back. Biopsy. Diagnosis, Differential. Humans. Male. Stomach Neoplasms / drug therapy

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  • (PMID = 17567316.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] U3P01618RT / Fluorouracil
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64. Das SK, Hashimoto T, Shimizu K, Yoshida T, Sakai T, Sowa Y, Komoto A, Kanazawa K: Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1. Biochim Biophys Acta; 2005 Nov 30;1726(3):328-35
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  • Fucoxanthin, a natural carotenoid, has been reported to have antitumorigenic activity in mouse colon, skin and duodenum models.
  • The present study was designed to evaluate the molecular mechanisms of fucoxanthin against colon cancer using the human colon adenocarcinoma cell lines.
  • According to the experiments using the isogenic human colon adenocarcinoma cell lines, fucoxanthin failed to induce G0/G1 arrest in the p21-deficient HCT116 cells, but not in HCT116 wild-type cells.

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  • (PMID = 16236452.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Retinoblastoma Protein; 0 / Xanthophylls; 06O0TC0VSM / fucoxanthin
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65. Kong X, Wang X, Xu W, Behera S, Hellermann G, Kumar A, Lockey RF, Mohapatra S, Mohapatra SS: Natriuretic peptide receptor a as a novel anticancer target. Cancer Res; 2008 Jan 1;68(1):249-56
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  • NPRA deficiency also substantially protected C57BL/6 mice from lung, skin, and ovarian cancers.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Animals. Apoptosis. Cell Transformation, Neoplastic / genetics. Female. Inflammation / genetics. Inflammation / pathology. Lung Neoplasms / genetics. Lung Neoplasms / pathology. Mice. Mice, Knockout. Mice, Mutant Strains. NF-kappa B / metabolism. Nanoparticles / therapeutic use. Ovarian Neoplasms / genetics. RNA Interference. RNA, Small Interfering / genetics. Retinoblastoma Protein / metabolism. Skin Neoplasms / genetics. Vascular Endothelial Growth Factor A / antagonists & inhibitors. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 18172317.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01-5HL71101A2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NF-kappa B; 0 / RNA, Small Interfering; 0 / Retinoblastoma Protein; 0 / Vascular Endothelial Growth Factor A; EC 4.6.1.2 / Guanylate Cyclase; EC 4.6.1.2 / Receptors, Atrial Natriuretic Factor; EC 4.6.1.2 / atrial natriuretic factor receptor A
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66. Shieh JJ, Liu KT, Huang SW, Chen YJ, Hsieh TY: Modification of alternative splicing of Mcl-1 pre-mRNA using antisense morpholino oligonucleotides induces apoptosis in basal cell carcinoma cells. J Invest Dermatol; 2009 Oct;129(10):2497-506
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  • In this study, we found an imbalance between the expression levels of Mcl-1L and Mcl-1S in the skin basal cell carcinoma (BCC) cell line when compared with primary keratinocytes.
  • This shift increases the level of pro-apoptotic Mcl-1S and reduces the level of anti-apoptotic Mcl-1L, which induces apoptosis in BCC cells and AGS cells, a human gastric adenocarcinoma epithelial cell line.
  • [MeSH-major] Alternative Splicing / drug effects. Apoptosis / drug effects. Carcinoma, Basal Cell / pathology. Oligonucleotides, Antisense / pharmacology. Proto-Oncogene Proteins c-bcl-2 / genetics. RNA, Messenger / genetics. Skin Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Cell Line, Tumor. Humans. Keratinocytes / metabolism. Keratinocytes / pathology. Myeloid Cell Leukemia Sequence 1 Protein. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology

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  • (PMID = 19369967.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Myeloid Cell Leukemia Sequence 1 Protein; 0 / Oligonucleotides, Antisense; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / RNA, Messenger
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67. Lapointe R, Létourneau R, Steward W, Hawkins RE, Batist G, Vincent M, Whittom R, Eatock M, Jolivet J, Moore M: Phase II study of troxacitabine in chemotherapy-naive patients with advanced cancer of the pancreas: gastrointestinal tumors. Ann Oncol; 2005 Feb;16(2):289-93
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  • The most common drug-related non-hematological toxic effects reported were cutaneous, with 22% and 6% of patients reporting grade 2 and 3 skin rash, respectively and 4% grade 2 hand-foot syndrome.
  • CONCLUSION: Troxacitabine administered by a bolus daily x5 monthly regimen has modest activity in advanced pancreatic adenocarcinoma.

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  • (PMID = 15668286.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Dioxolanes; 60KQZ0388Y / troxacitabine; 8J337D1HZY / Cytosine
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68. Durno CA, Holter S, Sherman PM, Gallinger S: The gastrointestinal phenotype of germline biallelic mismatch repair gene mutations. Am J Gastroenterol; 2010 Nov;105(11):2449-56
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  • Among the 29 patients with CRCs, the mean age of first cancer diagnosis was 16.4 years (range: 5-28).
  • Six individuals with biallelic MMR gene mutations have been reported with small bowel adenocarcinoma (mean age 20 years (range: 11-41)).
  • This distinct phenotype includes multiple adenomatous polyps and CAL skin lesions.

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  • (PMID = 20531397.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Lee HJ, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK: Metastatic gastric carcinoma presenting as an erythema annulare centrifugum-like lesion. J Dermatol; 2008 Mar;35(3):186-7
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  • [MeSH-major] Adenocarcinoma / secondary. Erythema / etiology. Skin Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 18346267.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
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70. Lai HY, Lim YY, Kim KH: Blechnum orientale Linn - a fern with potential as antioxidant, anticancer and antibacterial agent. BMC Complement Altern Med; 2010;10:15
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  • BACKGROUND: Blechnum orientale Linn. (Blechnaceae) is used ethnomedicinally for the treatment of various skin diseases, stomach pain, urinary bladder complaints and sterilization of women.
  • [MeSH-major] Adenocarcinoma / drug therapy. Anti-Bacterial Agents / therapeutic use. Antineoplastic Agents, Phytogenic / therapeutic use. Antioxidants / therapeutic use. Colonic Neoplasms / drug therapy. Ferns / chemistry. Phenols / pharmacology

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  • (PMID = 20429956.001).
  • [ISSN] 1472-6882
  • [Journal-full-title] BMC complementary and alternative medicine
  • [ISO-abbreviation] BMC Complement Altern Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Antioxidants; 0 / Biphenyl Compounds; 0 / Flavonoids; 0 / Free Radical Scavengers; 0 / Phenols; 0 / Picrates; 0 / Tannins; 0 / Terpenes; 1898-66-4 / 2,2-diphenyl-1-picrylhydrazyl
  • [Other-IDs] NLM/ PMC2881084
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71. Bugaj A, Kwitniewski M, Iani V, Juzeniene A, Juzenas P, Ma LW, Moan J: Photodynamic therapy with di-l-arginine protoporphyrinate on WiDr human colon adenocarcinoma xenografts in athymic nude mice. Photodiagnosis Photodyn Ther; 2007 Dec;4(4):237-41
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  • [Title] Photodynamic therapy with di-l-arginine protoporphyrinate on WiDr human colon adenocarcinoma xenografts in athymic nude mice.
  • The fluorescence kinetics of a new photosensitizer for photodynamic therapy, di-l-arginine protoporphyrinate (PP(Arg)2), was studied in the skin of healthy mice.
  • Furthermore, induction of necrosis in WiDr human colon adenocarcinoma xenografts in athymic nude mice was studied after photodynamic therapy (PDT) with PP(Arg)2.
  • After intravenous administration of PP(Arg)2 maximal fluorescence was reached after 72h in normal mouse skin.
  • Complete elimination of the drug from the mouse skin was not found even after 32 days.

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  • (PMID = 25047558.001).
  • [ISSN] 1572-1000
  • [Journal-full-title] Photodiagnosis and photodynamic therapy
  • [ISO-abbreviation] Photodiagnosis Photodyn Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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72. Srivastava AK, Jagetia A, Tatke M, Khurana N: Scalp and intracranial metastasis from pleomorphic adenocarcinoma of the parotid gland. Neurol India; 2007 Oct-Dec;55(4):433-4
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  • [Title] Scalp and intracranial metastasis from pleomorphic adenocarcinoma of the parotid gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Brain Neoplasms / secondary. Parotid Neoplasms / pathology. Scalp / pathology. Skin Neoplasms / secondary

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  • (PMID = 18040138.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
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73. Solberg TD, Nearman J, Mullins J, Li S, Baranowska-Kortylewicz J: Correlation between tumor growth delay and expression of cancer and host VEGF, VEGFR2, and osteopontin in response to radiotherapy. Int J Radiat Oncol Biol Phys; 2008 Nov 1;72(3):918-26
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  • [Title] Correlation between tumor growth delay and expression of cancer and host VEGF, VEGFR2, and osteopontin in response to radiotherapy.
  • PURPOSE: To determine the late effects of radiotherapy (RT) on vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR2), and osteopontin (OPN) expression in cancer and stromal cells.
  • METHODS AND MATERIALS: LS174T xenografted athymic mice were used as a tumor model.
  • Radiation was delivered in two equivalent fractionation schemes: 5 x 7 Gy and 1 x 20 Gy, the latter at two dose rates.
  • RESULTS: Tumor growth arrest was similar in all treatment groups, with the exception of a better response of small-size tumors in the 5 x 7-Gy group.
  • The host VEGF and OPN levels were directly proportional to the tumor doubling time and were independent of the fractionation scheme.
  • The host and cancer cell VEGFR2 levels in tumor were also directly related to the tumor response to RT.
  • CONCLUSION: Upregulated VEGFR2 in cancer cells suggest paracrine signaling in the VEGFR2 pathway of cancer cells as the factor contributing to RT failure.
  • The transient activation of the host VEGF/VEGFR2 pathway in tumor supports the model of angiogenic regeneration and suggests that radiation-induced upregulation of VEGF, VEGFR2, and downstream proteins might contribute to RT failure by escalating the rate of vascular repair.
  • Coexpression of host OPN and VEGF, two factors closely associated with angiogenesis, indicate that OPN can serve as a surrogate marker of tumor recovery after RT.
  • Taken together, these results strongly support the notion that to achieve optimal therapeutic outcomes, the scheduling of RT and antiangiogenic therapies will require patient-specific post-treatment monitoring of the VEGF/VEGFR2 pathway and that tumor-associated OPN can serve as an indicator of tumor regrowth.

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  • (PMID = 19014781.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA095267-03; United States / NCI NIH HHS / CA / R01 CA095267-03; United States / NCI NIH HHS / CA / R01 CA095267; United States / NCI NIH HHS / CA / CA095267-02; United States / NCI NIH HHS / CA / R01CA95267; United States / NCI NIH HHS / CA / R01 CA095267-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor A; 106441-73-0 / Osteopontin; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
  • [Other-IDs] NLM/ NIHMS74477; NLM/ PMC2585106
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74. Kim KJ, Lee DP, Lee MW, Choi JH, Moon KC, Koh JK: Penoscrotal extramammary Paget's disease in a patient with rectal cancer: double primary adenocarcinomas differentiated by immunoperoxidase staining. Am J Dermatopathol; 2005 Apr;27(2):171-2
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  • [MeSH-major] Adenocarcinoma / pathology. Genital Neoplasms, Male / pathology. Neoplasms, Multiple Primary / pathology. Paget Disease, Extramammary / pathology. Rectal Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 15798447.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Ohara T, Nishimoto H, Shimada K: [Cisplatin schedule in combination with gemcitabine in unresectable non-small cell lung cancer]. Gan To Kagaku Ryoho; 2005 Jan;32(1):69-71
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  • Grade 3 anorexia was 11%, and grade 3 skin rash which occurred in the first cycle 22%.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Aged. Cisplatin / administration & dosage. Drug Administration Schedule. Female. Humans. Infusions, Intravenous. Length of Stay. Leukopenia / chemically induced. Male. Middle Aged. Neutropenia / chemically induced

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  • (PMID = 15675585.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
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76. Wu CY, Gao HW, Huang WH, Chao CM: Infection-like acral cutaneous metastasis as the presenting sign of an occult breast cancer. Clin Exp Dermatol; 2009 Oct;34(7):e409-10
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  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / diagnosis. Neoplasms, Unknown Primary / diagnosis. Skin Neoplasms / secondary

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  • (PMID = 19747298.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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77. Malek J, Abbas O, Ghosn S, Salman S: Multiple nodules and plaques over the abdomen. Clin Exp Dermatol; 2010 Jun;35(4):e190-2
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  • [MeSH-major] Adenocarcinoma / secondary. Skin Neoplasms / secondary. Stomach Neoplasms

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  • (PMID = 20518912.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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78. Ambrosini V, Nanni C, Pettinato C, Fini M, D'Errico A, Trepidi S, Spinelli A, Al-Nahhas A, Rubello D, Zompatori M, Fabbri M, Franchi R, Fanti S: Assessment of a chemically induced model of lung squamous cell carcinoma in mice by 18F-FDG small-animal PET. Nucl Med Commun; 2007 Aug;28(8):647-52
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  • There are various murine models for human lung adenocarcinoma, but those for squamous cell lung carcinoma, the most common form of human cancer, are lacking.
  • MATERIALS AND METHODS: Nineteen NIH Swiss mice were skin painted by N-nitroso-tris-chloroethylurea (NTCU) twice a week, with a 3 day interval, for 8 months and 10 NIH Swiss mice skin painted with NTCU solvent (acetone) were used as controls.

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  • (PMID = 17625387.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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79. Alexandrescu DT, Vaillant J, Yahr LJ, Kelemen P, Wiernik PH: Unusually large colon cancer cutaneous and subcutaneous metastases occurring in resection scars. Dermatol Online J; 2005;11(2):22
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  • A 62-year-old woman developed an 11-cm midline abdominal mass that slowly grew on the skin surface.
  • The mass occurred at the scar site of her previous surgery performed 5 years prior for resection of a colon adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Cicatrix / complications. Colonic Neoplasms / pathology. Skin Neoplasms / secondary. Subcutaneous Tissue


80. Migowski A, Silva GA: Survival and prognostic factors of patients with clinically localized prostate cancer. Rev Saude Publica; 2010 Apr;44(2):344-52
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  • OBJECTIVE: To assess survival rates and clinical (pretreatment) prognostic factors in patients with clinically localized adenocarcinoma of the prostate.
  • Five- and ten-year survival functions were estimated using the Kaplan-Meier estimator from the histological diagnosis (initial time of follow-up) to death due to prostate cancer (events).
  • A Gleason score higher than 6, PSA levels higher than 40 ng/mL, B2 stage, and white skin color were independent markers of poor prognosis.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Prostatic Neoplasms / mortality. Prostatic Neoplasms / pathology

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  • [ErratumIn] Rev Saude Publica. 2010 Jun;44(3):579
  • (PMID = 20339635.001).
  • [ISSN] 1518-8787
  • [Journal-full-title] Revista de saúde pública
  • [ISO-abbreviation] Rev Saude Publica
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.77 / Prostate-Specific Antigen
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81. Espinoza-Cobos JC, Pérez-Figueroa J, Zúñiga-Ahuet G, Dorantes MA, Grube-Pagola P, Ruíz-Juárez I, Remes-Troche JM: [Oropharyngeal dysphagia as a first manifestation of dermatomyositis associated with colon cancer]. Rev Gastroenterol Mex; 2010 Oct-Dec;75(4):522-7
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  • Dermatomyositis (DM) is an idiopathic inflammatory myopathy associated with characteristic skin manifestations.
  • We report a case of a male patient aged 85 with DM associated with colon adenocarcinoma; progressive dysphagia was the first manifestation, and subsequently proximal muscle weakness and typical skin lesions were present.
  • A colonoscopy study and histopathologic examination revealed the presence of adenocarcinoma of the colon.
  • [MeSH-major] Adenocarcinoma / complications. Colonic Neoplasms / complications. Deglutition Disorders / etiology. Dermatomyositis / complications. Paraneoplastic Syndromes / etiology

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  • (PMID = 21169124.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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82. Gorva AD, Mohil R, Srinivasan MS: Aggressive digital papillary adenocarcinoma presenting as a paronychia of the finger. J Hand Surg Br; 2005 Oct;30(5):534
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  • [Title] Aggressive digital papillary adenocarcinoma presenting as a paronychia of the finger.
  • Aggressive digital papillary adenocarcinoma is a rare skin adnexal tumour, which has a predilection for the digits.
  • [MeSH-major] Adenocarcinoma, Papillary / diagnosis. Fingers / pathology. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Paronychia / diagnosis

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  • (PMID = 16055244.001).
  • [ISSN] 0266-7681
  • [Journal-full-title] Journal of hand surgery (Edinburgh, Scotland)
  • [ISO-abbreviation] J Hand Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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83. Kloos RT, Ringel MD, Knopp MV, Hall NC, King M, Stevens R, Liang J, Wakely PE Jr, Vasko VV, Saji M, Rittenberry J, Wei L, Arbogast D, Collamore M, Wright JJ, Grever M, Shah MH: Phase II trial of sorafenib in metastatic thyroid cancer. J Clin Oncol; 2009 Apr 1;27(10):1675-84
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  • Common grade 3 adverse events included hand-foot skin reaction, musculoskeletal pain, and fatigue.


84. Sueoka-Aragane N, Imai K, Komiya K, Sato A, Tomimasu R, Hisatomi T, Sakuragi T, Mitsuoka M, Hayashi S, Nakachi K, Sueoka E: Exon 19 of EGFR mutation in relation to the CA-repeat polymorphism in intron 1. Cancer Sci; 2008 Jun;99(6):1180-7
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  • Increased intrinsic EGFR mRNA expression in non-cancerous lung tissues from lung adenocarcinoma patients was also significantly associated with shorter CA-repeat length.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / secondary. Aged. Blotting, Western. Brain Neoplasms / genetics. Brain Neoplasms / secondary. Bronchi / cytology. Bronchi / metabolism. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / secondary. Cells, Cultured. DNA, Neoplasm / genetics. Epithelial Cells / metabolism. Female. Humans. Male. Neoplasm Staging. Pleural Effusion, Malignant / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Skin Neoplasms / genetics. Skin Neoplasms / secondary

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  • (PMID = 18422739.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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85. Schnopp C, Baumstark J: Images in clinical medicine. Oral acanthosis nigricans. N Engl J Med; 2007 Aug 30;357(9):e10
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  • [MeSH-major] Acanthosis Nigricans / etiology. Adenocarcinoma / complications. Paraneoplastic Syndromes / etiology. Stomach Neoplasms / complications
  • [MeSH-minor] Adult. Female. Humans. Skin / pathology

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  • (PMID = 17761587.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Jain V, Bhandary S, Prasad GN, Shenoi SD: Serpentine supravenous streaks induced by 5-fluorouracil. J Am Acad Dermatol; 2005 Sep;53(3):529-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adult. Humans. Male. Rectal Neoplasms / drug therapy. Skin / pathology

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  • (PMID = 16112371.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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87. Legoffic A, Calvo E, Cano C, Folch-Puy E, Barthet M, Delpero JR, Ferrés-Masó M, Dagorn JC, Closa D, Iovanna J: The reg4 gene, amplified in the early stages of pancreatic cancer development, is a promising therapeutic target. PLoS One; 2009;4(10):e7495
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  • BACKGROUND: The aim of our work was to identify the genes specifically altered in pancreatic adenocarcinoma and especially those that are altered early in cancer development.
  • The relationship betweena gain in reg4 gene copy number and cancer development was investigated on the human pancreatic cancer cell line Mia-PaCa2 xenografted under the skin of nude mice.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Gene Expression Regulation, Neoplastic. Lectins, C-Type / biosynthesis. Lectins, C-Type / genetics. Neoplasm Proteins / biosynthesis. Neoplasm Proteins / genetics. Pancreatic Neoplasms / genetics. Pancreatic Neoplasms / metabolism


88. Novotny AR, Florack G, Becker K, Siewert JR: Esophageal replacement by Lexer's esophagoplasty: adenocarcinoma as late complication. Ann Thorac Surg; 2005 Sep;80(3):1122-4
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  • [Title] Esophageal replacement by Lexer's esophagoplasty: adenocarcinoma as late complication.
  • The most successful method for esophageal reconstruction in the early 20th century was the jejunodermatoesophagoplasty after Lexer, involving the presternal formation of a skin tube for passage reconstruction.
  • A 59-year-old patient presented to our hospital with adenocarcinoma at the dermatojejunostomy 47 years after undergoing a Lexer procedure.
  • Although squamous cell carcinoma is known as a late complication of dermatoesophagoplasties, this is a reported case of adenocarcinoma formation.
  • [MeSH-major] Adenocarcinoma / etiology. Esophageal Neoplasms / etiology. Esophagoplasty / adverse effects

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  • (PMID = 16122509.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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89. Rzeski W, Matysiak J, Kandefer-Szerszeń M: Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound. Bioorg Med Chem; 2007 May 1;15(9):3201-7
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  • The tested compound inhibited proliferation of tumor cells derived from cancers of nervous system (medulloblastoma/rhabdosarcoma, neuroblastoma, and glioma) and peripheral cancers including colon adenocarcinoma and lung carcinoma.
  • Furthermore, in anticancer concentrations it exerted a trophic effect in neuronal cell culture and had no influence on viability of normal cells including astrocytes, hepatocytes, and skin fibroblasts.

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  • (PMID = 17350846.001).
  • [ISSN] 0968-0896
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2-(4-fluorophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole; 0 / Antineoplastic Agents; 0 / Neuroprotective Agents; 0 / Thiadiazoles; 0 / Thiazoles; 6L41AOK74P / 2-amino-1,3,4-thiadiazole
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90. Joh J, Jenson AB, Moore GD, Rezazedeh A, Slone SP, Ghim SJ, Kloecker GH: Human papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) in non small cell lung cancer. Exp Mol Pathol; 2010 Dec;89(3):222-6
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  • Merkel cell Polyomavirus (MCPyV) causes most Merkel cell carcinomas in immunocompromised hosts, and is associated with some squamous carcinomas of skin in immunocompetent individuals.
  • Three of the 5 were identified in squamous carcinomas, 1 in adenocarcinoma, and 1 in an unspecified NSCLC.
  • In one adenocarcinoma, HPV-11 was identified in an adenocarcinoma, and MCPyV DNA was detected in the adjacent "benign" tissue.


91. Darling MR, Tsai S, Jackson-Boeters L, Daley TD, Diamandis EP: Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors. Int J Biol Markers; 2006 Oct-Dec;21(4):201-5
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  • The human kallikrein 5 protein (hK5) is expressed in many normal tissues, most notably in skin, breast, salivary gland and esophagus.
  • Human kallikrein 3 (hK3; prostate-specific antigen) is the most useful marker for adenocarcinoma of the prostate gland.

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  • (PMID = 17177156.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.- / Kallikreins; EC 3.4.21.- / kallikrein 5, human; EC 3.4.21.77 / Prostate-Specific Antigen
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92. Zarovnaya E, Black C: Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Arch Pathol Lab Med; 2005 Aug;129(8):1032-6
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  • OBJECTIVE: To distinguish pseudoepitheliomatous hyperplasia from invasive squamous cell carcinoma, utilizing a panel of antibodies to various epithelial and stromal elements (p53, matrix metalloproteinase 1, E-cadherin, and collagen IV) that has been shown to be useful in differentiating intestinal adenomas with invasive adenocarcinoma from displaced adenomatous epithelium.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Granular Cell Tumor / diagnosis. Head and Neck Neoplasms / diagnosis. Mouth Mucosa / pathology. Skin Diseases / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy. Cadherins / metabolism. Child. Diagnosis, Differential. Female. Humans. Hyperplasia / pathology. Immunoenzyme Techniques. Male. Matrix Metalloproteinase 1 / metabolism. Middle Aged. Tumor Suppressor Protein p53 / metabolism


93. Kikuchi K, Hoashi T, Yazawa N, Tamaki K: Pseudoscleroderma associated with cancer. Clin Exp Dermatol; 2006 May;31(3):381-3
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  • In the period 1994-2002, we saw 71 patients with sclerotic skin changes; 66 were diagnosed with systemic sclerosis (SSc) while five (7%) were diagnosed with pseudoscleroderma associated with various malignancies.
  • The distributions of skin sclerosis varied in each case.
  • Elevated expression of bFGF was detected on fibroblasts of affected skin and in one lung-cancer tissue sample obtained by excision.
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / complications. Adenocarcinoma / immunology. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Breast Neoplasms / blood. Breast Neoplasms / complications. Breast Neoplasms / therapy. Carcinoma, Squamous Cell / blood. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / immunology. Case-Control Studies. Fatal Outcome. Female. Fibroblast Growth Factor 2 / analysis. Fibroblast Growth Factor 2 / blood. Humans. Immunosuppressive Agents / therapeutic use. Lung Neoplasms / blood. Lung Neoplasms / complications. Lung Neoplasms / secondary. Male. Middle Aged. Nasopharyngeal Neoplasms / blood. Nasopharyngeal Neoplasms / complications. Nasopharyngeal Neoplasms / immunology. Nasopharyngeal Neoplasms / therapy. Prednisolone / therapeutic use. Scleroderma, Systemic / metabolism. Skin / metabolism

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  • (PMID = 16681582.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Immunosuppressive Agents; 103107-01-3 / Fibroblast Growth Factor 2; 9PHQ9Y1OLM / Prednisolone
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94. Thurot-Guillou C, Bourrain JL, Jacquier JP, Beani JC: Anaphylactic reaction to ranitidine and dexchlorpheniramine. Eur J Dermatol; 2007 Mar-Apr;17(2):170-1
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  • [MeSH-major] Adenocarcinoma / drug therapy. Anaphylaxis / diagnosis. Drug Hypersensitivity / diagnosis. Endometrial Neoplasms / drug therapy. Histamine Antagonists / adverse effects
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / administration & dosage. Chlorpheniramine / adverse effects. Diagnosis, Differential. Emergency Treatment. Female. Humans. Infusions, Intravenous. Middle Aged. Paclitaxel / administration & dosage. Ranitidine / adverse effects. Skin Tests

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  • (PMID = 17337410.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Histamine Antagonists; 3Q9Q0B929N / dexchlorpheniramine; 3U6IO1965U / Chlorpheniramine; 884KT10YB7 / Ranitidine; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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95. Kantrow SM, Ivan D, Williams MD, Prieto VG, Lazar AJ: Metastasizing adenocarcinoma and multiple neoplastic proliferations arising in a nevus sebaceus. Am J Dermatopathol; 2007 Oct;29(5):462-6
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  • [Title] Metastasizing adenocarcinoma and multiple neoplastic proliferations arising in a nevus sebaceus.
  • Nevus sebaceus of Jadassohn is a hamartoma of multiple skin structures.
  • We report a case of a 66-year-old woman with an adenocarcinoma as well as multiple neoplastic proliferations arising in a long standing nevus sebaceus on the scalp, with subsequent occipital neck metastatic disease.
  • Most of the lesion was composed of an adenocarcinoma with areas showing ductal differentiation with decapitation secretion, well-formed papillae and focal cribriform structures.
  • [MeSH-major] Adenocarcinoma / secondary. Head and Neck Neoplasms / secondary. Nevus / pathology. Skin Neoplasms / pathology


96. Giordano G, Gnetti L, Ricci R, Merisio C, Melpignano M: Metastatic extragenital neoplasms to the uterus: a clinicopathologic study of four cases. Int J Gynecol Cancer; 2006 Jan-Feb;16 Suppl 1:433-8
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  • We considered the metastases in non-genital tract organs at diagnosis of primary neoplasm, the distribution of the metastases in the uterus, and the presence of concomitant metastases in other genital and non-genital tract organs.
  • The other two primary tumors were adenocarcinoma of the cecum and malignant melanoma of the skin.
  • The diagnosis was facilitated by clinical history, revealing the previous primary neoplasm, and by specific immunohistochemical study.
  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / pathology. Cecal Neoplasms / pathology. Melanoma / secondary. Skin Neoplasms / pathology. Uterine Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Prognosis

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  • (PMID = 16515640.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Greenberg HL, Lopez L, Butler DF: Peristomal metastatic adenocarcinoma of the rectum. Arch Dermatol; 2006 Oct;142(10):1372-3
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  • [Title] Peristomal metastatic adenocarcinoma of the rectum.
  • [MeSH-major] Adenocarcinoma / diagnosis. Rectal Neoplasms / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Colostomy. Diagnosis, Differential. Female. Humans. Neoplasm Metastasis

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  • (PMID = 17043208.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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98. Yendluri V, Centeno B, Springett GM: Pancreatic cancer presenting as a Sister Mary Joseph's nodule: case report and update of the literature. Pancreas; 2007 Jan;34(1):161-4
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  • We report a case of pancreatic adenocarcinoma in which the initial presenting sign was a SMJN.
  • This case emphasizes that pancreatic cancer should be considered in the differential diagnosis of umbilical metastasis.
  • [MeSH-major] Adenocarcinoma / secondary. Pancreatic Neoplasms / pathology. Skin Neoplasms / secondary. Umbilicus
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Laparoscopy. Tomography, X-Ray Computed

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  • (PMID = 17198200.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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99. Tiseo M, Gridelli C, Cascinu S, Crinò L, Piantedosi FV, Grossi F, Brandes AA, Labianca R, Siena S, Amoroso D, Belvedere O, Valentino B, Bearz A, Venturino P, Ardizzoni A: An expanded access program of erlotinib (Tarceva) in patients with advanced non-small cell lung cancer (NSCLC): data report from Italy. Lung Cancer; 2009 May;64(2):199-206
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  • Patient characteristics were: median age 66 years (range 30-87), male 69%, former or current smoker 71%, ECOG PS 0-1 81%, adenocarcinoma histology 52% and stage IV 82%.
  • Median progression-free survival was 15 weeks and was longer in females (p<0.001), patients with adenocarcinoma (p=0.008), those with no smoking history (p<0.001) and patients who experienced skin toxicity (p<0.001).

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  • (PMID = 18951651.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase IV; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride
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100. Salemis NS: Umbilical metastasis or Sister Mary Joseph's nodule as a very early sign of an occult cecal adenocarcinoma. J Gastrointest Cancer; 2007;38(2-4):131-4
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  • [Title] Umbilical metastasis or Sister Mary Joseph's nodule as a very early sign of an occult cecal adenocarcinoma.
  • It may be the first sign of an underlying adenocarcinoma, originating mainly from the gastrointestinal or genitourinary tract.
  • An extremely rare case of a Sister Mary Joseph's nodule is described herein, where the metastatic umbilical nodule was the first sign of a cecal adenocarcinoma and became evident 8 months before the onset of the disease.
  • [MeSH-major] Adenocarcinoma / diagnosis. Cecal Neoplasms / diagnosis. Skin Neoplasms / diagnosis. Umbilicus / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Fatal Outcome. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19089666.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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