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1. Dulucq JL, Wintringer P, Stabilini C, Mahajna A: Laparoscopic rectal resection with anal sphincter preservation for rectal cancer: long-term outcome. Surg Endosc; 2005 Nov;19(11):1468-74
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  • [Title] Laparoscopic rectal resection with anal sphincter preservation for rectal cancer: long-term outcome.
  • BACKGROUND: Total mesorectal excision (TME) is the surgical gold standard treatment for middle and low third rectal carcinoma.
  • The purposes of this study were to examine prospectively our experience with laparoscopic TME and high rectal resections, to evaluate the surgical outcomes and oncologic adequacy, and to discuss the role of this procedure in the treatment of rectal cancer.
  • METHODS: Between December 1992 and December 2004, all patients who underwent elective laparoscopic sphincter preserving rectal resection for rectal cancer were enrolled prospectively in this study.
  • CONCLUSION: Laparoscopic anterior resection and TME with anal sphincter preservation for rectal cancer is feasible and safe.
  • [MeSH-major] Laparoscopy. Rectal Neoplasms / surgery

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  • (PMID = 16222464.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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2. Prall F, Wöhlke M, Klautke G, Schiffmann L, Fietkau R, Barten M: Tumour regression and mesorectal lymph node changes after intensified neoadjuvant chemoradiation for carcinoma of the rectum. APMIS; 2006 Mar;114(3):201-10
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  • [Title] Tumour regression and mesorectal lymph node changes after intensified neoadjuvant chemoradiation for carcinoma of the rectum.
  • Neoadjuvant radiation or chemoradiation is currently the treatment of choice for patients with locally advanced carcinoma of the rectum.
  • [MeSH-major] Lymph Nodes / pathology. Neoadjuvant Therapy. Rectal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Antigens, CD / metabolism. Antimetabolites, Antineoplastic / pharmacology. Antineoplastic Agents, Phytogenic / pharmacology. Camptothecin / analogs & derivatives. Camptothecin / pharmacology. Capecitabine. Dendritic Cells / metabolism. Deoxycytidine / analogs & derivatives. Deoxycytidine / pharmacology. Female. Fluorouracil / pharmacology. Humans. Immunoglobulins / metabolism. Male. Membrane Glycoproteins / metabolism. Middle Aged

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  • (PMID = 16643187.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / CD83 antigen; 0 / Immunoglobulins; 0 / Membrane Glycoproteins; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; 7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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3. Gupta NP, Ansari MS, Dass SC: Transrectal ultrasound guided biopsy for detecting early prostate cancer: An Indian experience. Indian J Cancer; 2005 Jul-Sep;42(3):151-4
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  • [Title] Transrectal ultrasound guided biopsy for detecting early prostate cancer: An Indian experience.
  • The sextant biopsy technique has been conventionally used for the diagnosis of prostate cancer.
  • We conducted a prospective study to determine whether the 5-region prostate biopsy technique significantly increases the chance of prostate cancer detection as compared to the sextant biopsy technique.
  • AIMS: To evaluate the efficacy of TRUS guided sextant and 5-region biopsy techniques in detecting carcinoma prostate in patients with PSA between 4 and 10 ng/ml and normal digital rectal examination.
  • METHODS AND MATERIAL: Between December 2001 and August 2003 one forty-two men, aged 49-82 years, who presented with LUTS, normal digital rectal examination (DRE) and PSA between 4 and 10 ng/ml underwent TRUS guided sextant prostate biopsy.
  • Serum PSA was reassessed after 3 months in patients whose biopsies were negative for cancer.
  • TRUS guided sextant biopsy revealed adenocarcinoma prostate in 34 men (24%).
  • Five (10.4%) patients were detected to have adenocarcinoma on repeat biopsy.
  • [MeSH-minor] Aged. Aged, 80 and over. Humans. India. Male. Middle Aged. Prospective Studies. Prostatic Hyperplasia / pathology. Prostatic Hyperplasia / ultrasonography. Rectum / ultrasonography. Time Factors


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4. Tsamandas AC, Kardamakis D, Petsas T, Zolota V, Vassiliou V, Matatsoris T, Kalofonos H, Vagianos CE, Scopa CD: Bcl-2, bax and p53 expression in rectal adenocarcinoma. Correlation with classic pathologic prognostic factors and patients' outcome. In Vivo; 2007 Jan-Feb;21(1):113-8
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  • [Title] Bcl-2, bax and p53 expression in rectal adenocarcinoma. Correlation with classic pathologic prognostic factors and patients' outcome.
  • This study examined the bcl-2, bax and p53 expression in rectal adenocarcinomas and their relationship with tumor prognosis.
  • PATIENTS AND METHODS: Paraffin-embedded 4-microm tumor sections obtained from patients with rectal adenocarcinoma who underwent colectomy for therapeutic reasons, were analyzed with a standard streptavidin biotin peroxidase method, using polyclonal and monoclonal antibodies.
  • CONCLUSION: In rectal adenocarcinoma, bax and bcl-2 proteins co-express frequently with p53.
  • [MeSH-major] Adenocarcinoma / pathology. Proto-Oncogene Proteins c-bcl-2 / metabolism. Rectal Neoplasms / pathology. Tumor Suppressor Protein p53 / metabolism. bcl-2-Associated X Protein / metabolism
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Survival Rate

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  • [ErratumIn] In Vivo. 2007 May-Jun;21(3):553. Zolota, V [added]; Vassiliou, V [added]; Matatsoris, T [added]
  • [ErratumIn] In Vivo. 2007 Nov-Dec;21(6):1172
  • (PMID = 17354623.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein
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5. Robinson B, Frizelle F, Dickson M, Frampton C: Colorectal cancer treated at Christchurch Hospital, New Zealand: a comparison of 1993 and 1998 cohorts. N Z Med J; 2005 Feb 25;118(1210):U1323
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  • [Title] Colorectal cancer treated at Christchurch Hospital, New Zealand: a comparison of 1993 and 1998 cohorts.
  • AIM: To compare clinicopathological variables, management, and outcome of two cohorts of unselected patients treated for colorectal cancer (CRC) at Christchurch Hospital, New Zealand in 1993-94 and 1998-99.
  • RESULTS: 356 patients in 1993-94 and 317 patients in 1998-99 had a confirmed diagnosis of adenocarcinoma of the colon or rectum.
  • [MeSH-major] Adenocarcinoma / surgery. Colorectal Neoplasms / surgery
  • [MeSH-minor] Analysis of Variance. Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant / utilization. Cohort Effect. Elective Surgical Procedures. Humans. Multivariate Analysis. Neoplasm Staging. New Zealand / epidemiology. Retrospective Studies. Survival Analysis. Tomography, X-Ray Computed / utilization. Treatment Outcome

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  • [CommentIn] N Z Med J. 2005 Feb 25;118(1210):U1330 [15776102.001]
  • (PMID = 15776099.001).
  • [ISSN] 1175-8716
  • [Journal-full-title] The New Zealand medical journal
  • [ISO-abbreviation] N. Z. Med. J.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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6. Baatrup G, Elbrønd H, Hesselfeldt P, Wille-Jørgensen P, Møller P, Breum B, Qvist N: Rectal adenocarcinoma and transanal endoscopic microsurgery. Diagnostic challenges, indications and short term results in 142 consecutive patients. Int J Colorectal Dis; 2007 Nov;22(11):1347-52
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  • [Title] Rectal adenocarcinoma and transanal endoscopic microsurgery. Diagnostic challenges, indications and short term results in 142 consecutive patients.
  • PURPOSE: The objective of this study was to present short-term results of transanal endoscopic microsurgery (TEM) of rectal adenocarcinomas registered in a national database.
  • The perioperative course of all rectal cancers treated with TEM and registered in this database is analysed.
  • RESULTS: One hundred forty-two patients had TEM for rectal cancer.
  • In 43%of the patients, the cancer diagnosis was not recognized before TEM.
  • Eighty-five percent of all tumors were classified as benign based on macroscopic appearance; on digital rectal examination, 35% were benign, rectal ultrasound classified 15% as benign, and the preoperative biopsy was benign in 36%.
  • CONCLUSION: All larger rectal tumors should be evaluated for malignancy before treatment, even if TEM is the only surgical option, due to high age and comorbidiy.
  • Rectal ultrasound appears to produce the fewest false negative results, but it should be combined with biopsies and clinical evaluation.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / diagnosis. Rectal Neoplasms / surgery

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  • (PMID = 17643251.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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7. Mohandas S, Lake S: Primary adenocarcinoma of ileostomy: case report with review of the literature. Case Rep Med; 2010;2010:921328
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  • [Title] Primary adenocarcinoma of ileostomy: case report with review of the literature.
  • Primary adenocarcinoma is a rare and late complication following proctocolectomy and ileostomy for ulcerative colitis, familial adenomatous polyposis, Crohn's disease and multifocal colorectal cancer.
  • We report a case of adenocarcinoma of the ileostomy occurring 48 years after proctocolectomy for ulcerative colitis.
  • A review of the literature suggests that there are 39 cases reported in literature and this case reports the longest interval between formation of ileostomy and diagnosis of ileostomy adenocarcinoma.
  • Onces diagnosis is confirmed by biopsy enblock excision with or without stomal relocation is the main stay of treatment.
  • Patient education and regular surveillance of patients with long-standing ileostomy is recommended for early detection of this unusual cancer.

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  • (PMID = 20368789.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2846355
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8. Dresen RC, Beets GH, Vliegen RF, Creytens DH, Beets-Tan RG: Linitis plastica of the rectum secondary to bladder carcinoma: a report of two cases and its MR features. Br J Radiol; 2008 Oct;81(970):e249-51
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  • [Title] Linitis plastica of the rectum secondary to bladder carcinoma: a report of two cases and its MR features.
  • Rectal linitis plastica (RLP) is a circumferentially infiltrating intramural anaplastic carcinoma that results in a rigid constricted rectum with thickened walls.
  • A long delay between the onset of symptoms and the diagnosis often occurs because RLP can mimic a lot of diseases and endoscopy and biopsies are often negative, owing to the fact that the mucosa is frequently unaffected in RLP.
  • RLP secondary to bladder cancer is rarely described in the English literature.
  • We present the first report of the MR features of secondary rectal linitis plastica from a bladder carcinoma.
  • In both patients, pelvic T(2) weighted MR images revealed a double-layered thickening of the rectal wall with an inner isointense circumferential thickening of the submucosa and outer hypointense circumferential thickening of the muscular rectal wall.
  • It is important to establish the diagnosis of RLP early because of its bad prognosis.
  • The value of MRI in supporting the diagnosis of RLP should not be underestimated.
  • As endoscopy plus biopsy can often be negative, we suggest that, if pelvic MRI shows a concentric double layered thickening of the rectal wall over a long segment, then the diagnosis of RLP should be considered.
  • This should prompt further investigations either to confirm or rule out the diagnosis of RLP by performing endoscopy with deep rectal wall biopsies.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Transitional Cell / secondary. Linitis Plastica / secondary. Rectal Neoplasms / secondary. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18796553.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Wang Y, Cummings B, Catton P, Dawson L, Kim J, Ringash J, Wong R, Yi QL, Brierley J: Primary radical external beam radiotherapy of rectal adenocarcinoma: long term outcome of 271 patients. Radiother Oncol; 2005 Nov;77(2):126-32
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  • [Title] Primary radical external beam radiotherapy of rectal adenocarcinoma: long term outcome of 271 patients.
  • BACKGROUND AND PURPOSE: To assess local control, survival and toxicity following primary radical external beam radiotherapy of rectal adenocarcinoma treated between 1978 and 1997, and to compare practices and outcomes between the two decades of study.
  • For patients with mobile, partially fixed and fixed tumors, overall 5 year survival was 48, 26 and 6%, respectively, and cancer specific 5 year survival was 59, 33 and 9%, respectively.
  • CONCLUSIONS: Radical external beam radiotherapy is a reasonable treatment option for rectal carcinoma for patients who are not surgical candidates or refuse surgery.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / radiotherapy. Radiotherapy, High-Energy / methods. Rectal Neoplasms / mortality. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Biopsy, Needle. Chi-Square Distribution. Dose-Response Relationship, Radiation. Female. Follow-Up Studies. Humans. Immunohistochemistry. Logistic Models. Male. Middle Aged. Neoplasm Staging. Probability. Radiation Dosage. Retrospective Studies. Risk Assessment. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 16216364.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
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10. Skalický T, Treska V, Spidlen V, Vodicka V, Sutnar A, Liska V, Klecka J, Simánek V, Safránek J, Fichtl J, Polák M: [Surgical treatment of liver and pulmonary metastases of colorectal carcinoma]. Rozhl Chir; 2010 Apr;89(4):253-5
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  • [Title] [Surgical treatment of liver and pulmonary metastases of colorectal carcinoma].
  • THE AIM: The aim of the work was to evaluate the set of 10 patients, who were operated on hepatic and pulmonary metastases of colorectal carcinoma at the Surgical Clinic of Medical Faculty of Charles University and Faculty Hospital in Plzeń in years from 2005 till 2009.
  • THE SET OF THE PATIENTS: In years from 2005 till 12/2009 we operated 10 patients during whose affection there occurred hepatic and pulmonary metastases of colorectal carcinoma and these were solved surgically.
  • In 10% it was hepatic resection in the first period after the operation of primary carcinoma, it was the first performance on the hepatic parenchyma in 90%.
  • In 4 cases primary carcinoma was in the rectum and in 6 cases in the large intestine.
  • Rectal carcinoma spread into lungs in 50%.
  • An average time of a 5-year survival in the patients after resection of hepatic and pulmonary metastases of colorectal carcinoma was 26%.
  • THE CONCLUSION: Hepatic and pulmonary resection in the selected patients with generalized colorectal carcinoma extends the period of a survival and does not worsen the quality of the life.
  • [MeSH-major] Carcinoma / secondary. Carcinoma / surgery. Colorectal Neoplasms / pathology. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Lung Neoplasms / secondary. Lung Neoplasms / surgery

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  • (PMID = 20586164.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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11. Rouanet P: [Preoperative treatment impact for ultralow rectal carcinoma sphincter preservation]. Cancer Radiother; 2006 Nov;10(6-7):451-5
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  • [Title] [Preoperative treatment impact for ultralow rectal carcinoma sphincter preservation].
  • [Transliterated title] Impact des traitements préopératoires (radiothérapie et chimiothérapie) dans la conservation sphinctérienne des cancers du très bas rectum.
  • Sphincter preservation for low rectal carcinoma must be evaluated with a plurifactoriel approach.
  • [MeSH-major] Limb Salvage. Reconstructive Surgical Procedures / methods. Rectum

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  • (PMID = 17005428.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 23
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12. Kuwabara M, Wada K, Maeda Y, Miyazaki A, Tsunemitsu H: First isolation of cytopathogenic bovine torovirus in cell culture from a calf with diarrhea. Clin Vaccine Immunol; 2007 Aug;14(8):998-1004
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  • A cytopathogenic virus (designated the Aichi/2004 strain) was isolated in a human rectal adenocarcinoma cell line (HRT-18) from the ileum contents of a calf with diarrhea.

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  • (PMID = 17567770.001).
  • [ISSN] 1556-6811
  • [Journal-full-title] Clinical and vaccine immunology : CVI
  • [ISO-abbreviation] Clin. Vaccine Immunol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AB285125/ AB285126/ AB285127
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / DNA, Viral; 0 / Viral Proteins
  • [Other-IDs] NLM/ PMC2044491
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13. Saad RS, Silverman JF, Khalifa MA, Rowsell C: CDX2, cytokeratins 7 and 20 immunoreactivity in rectal adenocarcinoma. Appl Immunohistochem Mol Morphol; 2009 May;17(3):196-201
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  • [Title] CDX2, cytokeratins 7 and 20 immunoreactivity in rectal adenocarcinoma.
  • There are limited data regarding CDX2 expression in rectal carcinoma.
  • The CK20/CK7 immunoprofile of colorectal adenocarcinoma has been described in studies, which have mostly lumped colonic and rectal tumors together.
  • In this study, we investigated the diagnostic utility of immunohistochemical stains for CK7, CK20, and CDX2 in a series of rectal adenocarcinoma.
  • Fifty-five specimens of rectal adenocarcinomas were retrieved and immunostained for CK7 (Dako-M7018), CK20 (NovoCastra NCL-L-CK20), and CDX2 (NovoCastra NCL-CDX2).
  • Thirty cases of pancreatic adenocarcinoma and 15 cholangiocarcinomas were also studied as a comparison group.
  • CK7 was expressed in 12/55 (22%) and CK20 in 48/55 (87%) cases of rectal adenocarcinoma.
  • The CK7-/CK20+ immunophenotype was identified in 36/55 (65%), CK7+/CK20+ in 12/55 (22%), and CK7-/CK20- in 7/55 (13%) rectal adenocarcinoma.
  • Benign rectal mucosa was available in 37 cases and showed the following results: CK7-/CK20+ in 25/37 (67%), CK7+/CK20+ in 8/37 (22%) and CK7-/CK20- in 4/37 (11%) cases.
  • In conclusion, CK7 can be expressed in rectal adenocarcinoma, and should not be used as the sole basis for excluding a rectal primary.
  • CDX2 is a sensitive marker for rectal origin of adenocarcinoma.
  • It can be helpful in cases with metastatic rectal carcinoma, especially those with CK7+/CK20+ or CK20-/CK7- immunophenotype.
  • In this study, CDX2 expression was not influenced by the grade (differentiation) of rectal adenocarcinoma.

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  • [ErratumIn] Appl Immunohistochem Mol Morphol. 2009 Oct;17(5):464
  • (PMID = 19098678.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Keratin-7
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14. Li M, Gu J: Changing patterns of colorectal cancer in China over a period of 20 years. World J Gastroenterol; 2005 Aug 14;11(30):4685-8
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  • [Title] Changing patterns of colorectal cancer in China over a period of 20 years.
  • AIM: To determine whether any changes have occurred on the patterns of colorectal cancer in China.
  • METHODS: Data from 21 Chinese articles published from 1980 to 1999, were used to analyze the time trend of colorectal cancer according to the patients' age at diagnosis, sex, the site of the tumor, stage, and the pathology.
  • RESULTS: From 1980s to 1990s, the mean age of the colorectal cancer patients has increased.
  • The distribution of colorectal carcinoma shows a predominance of rectal cancer.
  • However, the proportion of proximal colon cancer (including transverse and ascending colon) increased significantly accompanied by a decline in the percentage of rectal cancer.
  • Similarity in the percentage of distal colon cancer between two decades was revealed.
  • The proportion of adenocarcinoma increased, but the mucinous adenocarcinoma decreased during two decades.
  • CONCLUSION: These findings indicate that the pattern of colorectal cancer in China has been changing.
  • Especially, a proximal shift due to the increasing proportion of ascending and transverse colon cancer has occurred in China.
  • [MeSH-minor] China / epidemiology. Colonic Neoplasms / epidemiology. Female. Humans. Male. Middle Aged. Rectal Neoplasms / epidemiology. Sex Distribution. Time Factors


15. Göhl J, Hohenberger W, Merkel S: Lymph node dissection in rectal carcinoma: TME and what else? Onkologie; 2009 Feb;32(1-2):57-61
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  • [Title] Lymph node dissection in rectal carcinoma: TME and what else?
  • Total mesorectal excision (TME) has been established as a standardized radical surgical procedure in malignant tumors of the middle and lower rectal third.
  • In carcinomas of the upper rectal third, TME is seen as controversial.
  • Total mesorectal excision in the radical surgical treatment of lower and middle third rectal carcinomas is the essential part of lymphatic dissection in these tumors.
  • [MeSH-major] Digestive System Surgical Procedures / methods. Lymph Node Excision / methods. Rectal Neoplasms / surgery

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  • [Copyright] Copyright (c) 2009 S. Karger AG, Basel.
  • (PMID = 19209023.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 44
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16. Kuester D, Dalicho S, Mönkemüller K, Benedix F, Lippert H, Guenther T, Roessner A, Meyer F: Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis. Pathol Res Pract; 2008;204(12):905-10
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  • [Title] Synchronous multifocal colorectal carcinoma in a patient with delayed diagnosis of ulcerative pancolitis.
  • Patients with ulcerative colitis face an increased lifetime risk of developing colorectal cancer.
  • Regardless of the diagnosis and medical advice, the patient initially refused therapy, and proctocolectomy was delayed for 12 months.
  • In the resection specimen, four clinically unsuspected, partly mucinous adenocarcinomas accompanied by several foci of low- and high-grade dysplasia were found in the left colon and rectum.
  • [MeSH-major] Adenocarcinoma / pathology. Colitis, Ulcerative / complications. Colitis, Ulcerative / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adult. Appendiceal Neoplasms / pathology. Cystadenoma, Mucinous / pathology. Humans. Male. Neoplasm Staging. Neoplasms, Multiple Primary / pathology

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  • [CommentIn] Zentralbl Chir. 2015 Dec;140(6):624-6 [25076166.001]
  • (PMID = 18842350.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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17. Nahas CS, Shia J, Joseph R, Schrag D, Minsky BD, Weiser MR, Guillem JG, Paty PB, Klimstra DS, Tang LH, Wong WD, Temple LK: Squamous-cell carcinoma of the rectum: a rare but curable tumor. Dis Colon Rectum; 2007 Sep;50(9):1393-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous-cell carcinoma of the rectum: a rare but curable tumor.
  • PURPOSE: This study was designed to evaluate one institution's experience with treatment outcomes for rectal squamous-cell carcinoma.
  • METHODS: Using our prospective Colorectal Database, we identified patients diagnosed with rectal squamous-cell carcinoma at our institution between 1983 and 2005.
  • Pathology was rereviewed, tumor immunophenotype was compared to control cases of anal squamous-cell carcinoma and rectal adenocarcinoma, treatment modalities and outcomes were analyzed.
  • Immunophenotypical analysis showed similar keratin expression profile between rectal squamous-cell carcinoma (n = 5) and rectal adenocarcinoma (n = 5), which is different from anal squamous-cell carcinoma (n = 10).
  • Immunohistochemistry suggests a common cellular origin for rectal squamous-cell carcinoma and rectal adenocarcinoma, which is different from anal squamous-cell carcinoma.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Carcinoma, Squamous Cell / therapy. Colectomy. Fluorouracil / therapeutic use. Rectal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Female. Follow-Up Studies. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Radiotherapy, Adjuvant. Survival Rate. Treatment Outcome. United States / epidemiology

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  • (PMID = 17661147.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Biomarkers, Tumor; 68238-35-7 / Keratins; U3P01618RT / Fluorouracil
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18. Kurt M, Ozkan L, Kurt E, Cetintas SK, Aygun S, Ercan I, Yilmazlar T, Memik F: Comparison of protracted infusion 5-fluorouracil and capecitabine in adjuvant chemoradiotherapy for rectal cancer. Hepatogastroenterology; 2008 Jul-Aug;55(85):1158-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of protracted infusion 5-fluorouracil and capecitabine in adjuvant chemoradiotherapy for rectal cancer.
  • BACKGROUND/AIMS: 5-Fluorouracil-based chemoradiotherapy is the most widely used treatment modality in the adjuvant treatment of rectal cancer.
  • METHODOLOGY: Patients with stage II and stage III rectal adenocarcinoma, who were included in this analysis, received adjuvant chemoradiotherapy consisting of external-beam radiotherapy (50.4-54Gy) either with 5-Fluorouracil at a median dose of 300 mg/m2/day by protracted venous infusion for 5 days a week, or capecitabine at a median dose of 1650 mg/m2/day for 5 days a week after surgery.
  • CONCLUSIONS: Capecitabine is at least as effective as 5-Fluorouracil in the postoperative treatment of rectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / therapy. Antimetabolites, Antineoplastic / administration & dosage. Deoxycytidine / analogs & derivatives. Fluorouracil / administration & dosage. Fluorouracil / analogs & derivatives. Rectal Neoplasms / therapy

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  • (PMID = 18795649.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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19. Matsuoka H, Nakamura A, Masaki T, Sugiyama M, Nitatori T, Ohkura Y, Sakamoto A, Atomi Y: Optimal diagnostic criteria for lateral pelvic lymph node metastasis in rectal carcinoma. Anticancer Res; 2007 Sep-Oct;27(5B):3529-33
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  • [Title] Optimal diagnostic criteria for lateral pelvic lymph node metastasis in rectal carcinoma.
  • AIM: The purpose of this study was to determine the optimal diagnostic criteria for lateral pelvic lymph node metastasis in patients with rectal carcinoma.
  • PATIENTS AND METHODS: From July 1997 to June 2005, fifty-one patients with locally advanced middle or lower rectal carcinoma underwent preoperative MRI examination, followed by total mesorectal excision with lateral pelvic node dissection.
  • CONCLUSION: An ovoid shape with a transverse axis diameter of 5 mm or larger on MRI was considered as the optimal criterion for diagnosing lateral lymph node metastasis in patients with rectal carcinoma.
  • [MeSH-major] Lymph Nodes / pathology. Pelvic Neoplasms / pathology. Rectal Neoplasms / diagnosis. Rectal Neoplasms / secondary

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  • (PMID = 17972513.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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20. Vagliasindi A, Teodorani N, Palazzi S, Mura G, Framarini M, Mazza P, Datiti A, Rosetti P, Curcio A, Verdecchia GM: [Neoadjuvant radiochemotherapy of rectal carcinoma: retrospective analysis of a personal experience]. Suppl Tumori; 2005 May-Jun;4(3):S24-5
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  • [Title] [Neoadjuvant radiochemotherapy of rectal carcinoma: retrospective analysis of a personal experience].
  • [Transliterated title] Radiochemioterapia neoadiuvante nel carcinoma del retto analisi retrospettiva di un'esperienza personale.
  • Even if surgical resection continues to be the mainstay of treatment in rectal cancer, preoperative chemoradiation may downstage locally advanced rectal cancer, in some cases with no residual tumors.
  • Compared with surgery alone, preoperative radiotherapy and chemotherapy improves outcomes in patients with locally advanced rectal cancer.
  • In the present review we summarize the results of preoperative chemoradiation therapy in a group of 15 patients who underwent surgical resection with total mesorectal excision (TME) for advanced mid and low rectal cancer from February 2002 to February 2004.
  • [MeSH-major] Rectal Neoplasms / therapy

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  • (PMID = 16437881.001).
  • [ISSN] 2283-5423
  • [Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
  • [ISO-abbreviation] Suppl Tumori
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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21. Zhang XM, Yu D, Zhang HL, Dai Y, Bi D, Liu Z, Prince MR, Li C: 3D dynamic contrast-enhanced MRI of rectal carcinoma at 3T: correlation with microvascular density and vascular endothelial growth factor markers of tumor angiogenesis. J Magn Reson Imaging; 2008 Jun;27(6):1309-16
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  • [Title] 3D dynamic contrast-enhanced MRI of rectal carcinoma at 3T: correlation with microvascular density and vascular endothelial growth factor markers of tumor angiogenesis.
  • PURPOSE: To determine how dynamic contrast-enhanced (DCE) MRI at 3T correlates with rectal carcinoma angiogenesis.
  • MATERIALS AND METHODS: Three-dimensional (3D) DCE MRI was performed in 38 patients (23 males, 15 females, mean age 60 years) with histologically-confirmed rectal carcinoma at 3T.
  • Time-intensity curves (TICs) were used to measure peak enhancement ratio (ER(peak)), time to peak enhancement (T(peak)), first enhancement time (T(first-enhance)), and uptake rate for rectal tumor, normal rectal wall, and gluteal muscle.
  • RESULTS: Rectal carcinoma showed higher ER(peak) (3.0 +/- 0.9 vs. 1.9 +/- 0.9, P < 0.001), higher uptake rate (2.8 +/- 1.5/minute vs. 1.2 +/- 0.9/minute, P < 0.001), earlier T(peak) (88 +/- 56 seconds vs. 124 +/- 72 seconds, P = 0.027), and earlier T(first-enhance) (34 +/- 6 seconds vs. 40 +/- 7 seconds, P = 0.008) than normal rectal wall.
  • Adenocarcinoma had shorter T(peak) compared to signet cell carcinoma (77 +/- 48 seconds vs. 160 +/- 62 seconds, P = 0.004).
  • CONCLUSION: DCE MRI parameters help predict rectal tumor angiogenesis measured by MVD and VEGF expression and discriminate malignant from normal tissue.
  • [MeSH-major] Adenocarcinoma / blood supply. Carcinoma, Signet Ring Cell / blood supply. Contrast Media / administration & dosage. Imaging, Three-Dimensional / methods. Magnetic Resonance Imaging / methods. Neovascularization, Pathologic / diagnosis. Rectal Neoplasms / blood supply
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers / metabolism. Female. Gadolinium DTPA. Humans. Image Enhancement / methods. Magnetics. Male. Middle Aged. Rectum / blood supply. Rectum / pathology. Vascular Endothelial Growth Factor A / metabolism

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  • [Copyright] 2008 Wiley-Liss, Inc
  • (PMID = 18504761.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Contrast Media; 0 / Vascular Endothelial Growth Factor A; K2I13DR72L / Gadolinium DTPA
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22. Bright E, Manuel C, Goddard JC, Khan MA: Incidence and variables predicting Gleason score up-grading between trans-rectal ultrasound-guided prostate biopsies and radical prostatectomy. Urol Int; 2010;84(2):180-4
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  • [Title] Incidence and variables predicting Gleason score up-grading between trans-rectal ultrasound-guided prostate biopsies and radical prostatectomy.
  • OBJECTIVE: To determine whether Gleason score up-grading is still occurring in men diagnosed with adenocarcinoma of the prostate via extended biopsy regimens, and factors that might predict this.
  • PATIENTS AND METHODS: Between September 1999 and February 2007, 211 men (age: 42-70 years; mean: 60 years) underwent trans-rectal ultrasound-guided prostate biopsies confirming clinically localized adenocarcinoma followed by radical prostatectomy (RP), within our department.
  • CONCLUSION: Despite increasing the number of cores taken at biopsy, in order to improve prostate cancer diagnosis, a substantial percentage of men still experience Gleason score up-grading from biopsy to RP.
  • [MeSH-major] Adenocarcinoma / surgery. Adenocarcinoma / ultrasonography. Biopsy / methods. Prostate / pathology. Prostatectomy / methods. Prostatic Neoplasms / surgery. Prostatic Neoplasms / ultrasonography. Rectum / ultrasonography. Ultrasonography / methods


23. Vuong T, Devic S, Moftah B, Evans M, Podgorsak EB: High-dose-rate endorectal brachytherapy in the treatment of locally advanced rectal carcinoma: technical aspects. Brachytherapy; 2005;4(3):230-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-dose-rate endorectal brachytherapy in the treatment of locally advanced rectal carcinoma: technical aspects.
  • PURPOSE: In this era of new radiation technologies and tumor imaging, a high-dose-rate endorectal brachytherapy has been developed and tested in a phase I/II study of advanced rectal tumors.
  • Patients with resectable rectal cancer (staged T2, T3, or early T4) were treated with preoperative high-dose-rate endorectal brachytherapy followed by surgery 6-8 weeks later.
  • The use of a multichannel flexible endorectal applicator leads to tumor downstaging before surgery in patients with resectable locally advanced rectal carcinomas.
  • [MeSH-major] Brachytherapy / instrumentation. Brachytherapy / methods. Radiotherapy Planning, Computer-Assisted / methods. Rectal Neoplasms / radiography. Rectal Neoplasms / radiotherapy

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  • (PMID = 16182224.001).
  • [ISSN] 1538-4721
  • [Journal-full-title] Brachytherapy
  • [ISO-abbreviation] Brachytherapy
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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24. Hermanek P, Junginger T: The circumferential resection margin in rectal carcinoma surgery. Tech Coloproctol; 2005 Dec;9(3):193-9; discussion 199-200
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  • [Title] The circumferential resection margin in rectal carcinoma surgery.
  • After radical resection of rectal carcinoma, the circumferential resection margin (CRM) on the non-peritonealized surface of the resected specimen is of critical importance.
  • [MeSH-major] Colectomy / methods. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / pathology. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Colonoscopy / methods. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neoadjuvant Therapy / methods. Neoplasm Staging. Predictive Value of Tests. Preoperative Care. Prognosis. Risk Assessment. Sensitivity and Specificity. Survival Analysis. Treatment Outcome

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  • (PMID = 16328130.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 14
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25. Koukourakis MI, Simopoulos C, Pitiakoudis M, Lyratzopoulos N, Romanidis K, Giatromanolaki A, Polychronidis A, Kouklakis G, Sivridis E, Minopoulos G, Manolas K: Hypofractionated accelerated radiotherapy, cytoprotection and capecitabine in the treatment of rectal cancer: a feasibility study. Anticancer Res; 2008 Sep-Oct;28(5B):3035-40
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  • [Title] Hypofractionated accelerated radiotherapy, cytoprotection and capecitabine in the treatment of rectal cancer: a feasibility study.
  • BACKGROUND: This is a report on the feasibility and efficacy of hypofractionated accelerated radiotherapy combined with amifostine cytoprotection (hypoARC) and capecitabine in the treatment of rectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / therapy. Amifostine / therapeutic use. Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Fluorouracil / analogs & derivatives. Radiation-Protective Agents / therapeutic use. Rectal Neoplasms / therapy

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  • (PMID = 19031952.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Radiation-Protective Agents; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; M487QF2F4V / Amifostine; U3P01618RT / Fluorouracil
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26. Agha A, Fürst A, Hierl J, Iesalnieks I, Glockzin G, Anthuber M, Jauch KW, Schlitt HJ: Laparoscopic surgery for rectal cancer: oncological results and clinical outcome of 225 patients. Surg Endosc; 2008 Oct;22(10):2229-37
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  • [Title] Laparoscopic surgery for rectal cancer: oncological results and clinical outcome of 225 patients.
  • INTRODUCTION: The efficacy and feasibility of laparoscopic resection for rectal cancer has been proved, but the results of prospective, randomized studies are not yet available.
  • Here we present a prospective observational study evaluating oncological and clinical outcome after laparoscopic surgery in patients with rectal cancer.
  • PATIENTS AND METHODS: Between January 1998 and March 2005, 225 patients with rectal adenocarcinoma underwent laparoscopic surgery at the University of Regensburg Medical Center.
  • RESULTS: The distribution of the International Union against Cancer (UICC) stages was: 37.7% stage I, 20.5% stage II, 24.9% stage III, and 16.9% stage IV.
  • CONCLUSIONS: Our results demonstrate the efficacy and technical feasibility of laparoscopic surgery for rectal cancer regarding the perioperative morbidity and the oncological outcome.
  • [MeSH-major] Adenocarcinoma / surgery. Laparoscopy. Rectal Neoplasms / surgery

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  • (PMID = 18622560.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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27. Wang LW, Yang SH, Lin JK, Lin TC, Chan WK, Chen WS, Wang HS, Jiang JK, Lee RC, Li AF, Chao Y, Chi KH, Yen SH: Pre-operative chemoradiotherapy with oral tegafur-uracil and leucovorin for rectal cancer. J Surg Oncol; 2005 Mar 15;89(4):256-63; discussion 263-4
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  • [Title] Pre-operative chemoradiotherapy with oral tegafur-uracil and leucovorin for rectal cancer.
  • BACKGROUND: To evaluate the efficacy and toxicity of pre-operative radiotherapy (RT) combined with oral tegafur-uracil (UFUR) plus leucovorin (LV) in rectal cancer.
  • PATIENTS: Sixty-five patients with rectal adenocarcinoma (clinical staged T2-4N0-2M0) received pelvic RT of 45 Gy in 20 fractions over 28 days.
  • CONCLUSIONS: Oral UFUR + LV administered with pre-operative RT are effective in tumor DS, pathological complete response, and sphincter preservation with tolerable toxicity in rectal cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Rectal Neoplasms / drug therapy

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  • [CommentIn] J Surg Oncol. 2005 May 1;90(2):106-7 [15844186.001]
  • [ErratumIn] J Surg Oncol. 2005 May 1;90(2):106
  • (PMID = 15726610.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / UFT(R) drug; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q573I9DVLP / Leucovorin
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28. Elshazly WG, Farouk M, Samy M: Preoperative concomitant radiotherapy with oral capecitabine in advanced rectal cancer within 6 cm from anal verge. Int J Colorectal Dis; 2009 Apr;24(4):401-7
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  • [Title] Preoperative concomitant radiotherapy with oral capecitabine in advanced rectal cancer within 6 cm from anal verge.
  • AIM: This study aimed to evaluate the role preoperative chemo-radiotherapy with oral capacitabine for advanced low rectal cancer within 6 cm of anal verge.
  • PATIENTS AND METHODS: Twenty-six patients with rectal adenocarcinoma were treated with preoperative radiotherapy, and oral capecitabine administrated at 5 days/week.
  • [MeSH-major] Anal Canal / pathology. Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Fluorouracil / analogs & derivatives. Preoperative Care. Rectal Neoplasms / drug therapy. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Administration, Oral. Adult. Capecitabine. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Patient Compliance. Survival Analysis. Treatment Outcome

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  • (PMID = 19084971.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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29. Sultan I, Rodriguez-Galindo C, El-Taani H, Pastore G, Casanova M, Gallino G, Ferrari A: Distinct features of colorectal cancer in children and adolescents: a population-based study of 159 cases. Cancer; 2010 Feb 1;116(3):758-65
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  • [Title] Distinct features of colorectal cancer in children and adolescents: a population-based study of 159 cases.
  • BACKGROUND: Colorectal cancer is exceedingly rare in children and adolescents.
  • METHODS: The Surveillance, Epidemiology, and End Results database was searched for records of children/adolescents with colorectal cancer, and the features and outcomes were compared with those of adults.
  • RESULTS: From January 1973 through December 2005, only 159 children/adolescents (ages 4-20 years) were reported with a diagnosis of colorectal cancer.
  • The most common sites of involvement were the rectum (27%) and the transverse colon (26%).
  • Adenocarcinoma was the most common histotype in both adults and pediatric patients; however, children/adolescents had more unfavorable histotypes (ie, mucinous adenocarcinoma [22%] and signet ring cell carcinoma [18%]) when compared with adults (10% and 1%, respectively; P < .001).
  • CONCLUSIONS: Children/adolescents represent a minority of patients with colorectal cancer and have high-risk features and worse outcome than adults.
  • Thus, the principles of management for adult colorectal cancer should be used in the treatment of children and adolescents.
  • [MeSH-major] Colorectal Neoplasms / diagnosis

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  • [Copyright] Copyright 2009 American Cancer Society.
  • (PMID = 19957323.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. Min BS, Kim NK, Ko YT, Lee KY, Baek SH, Cho CH, Sohn SK: Long-term oncologic results of patients with distal rectal cancer treated by local excision with or without adjuvant treatment. Int J Colorectal Dis; 2007 Nov;22(11):1325-30
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  • [Title] Long-term oncologic results of patients with distal rectal cancer treated by local excision with or without adjuvant treatment.
  • AIM: The aim of this study is to review long-term oncologic results of local excision (LE) and to investigate the validity and feasibility of LE as a treatment option for distal rectal cancer.
  • MATERIALS AND METHODS: Seventy-six patients who underwent LE for distal rectal adenocarcinoma with curative intent from 1991 to 2000 at Severance Hospital Yonsei University Medical Center, Seoul, Korea were enrolled in this study.
  • Postoperative pathologic examination revealed 10 cases of pT0 (where no residual cancer cells remained), 11 cases of pTis, 37 cases of pT1, 16 cases of pT2, and 2 cases of pT3.
  • Among the patients with pT1 cancer, those who received adjuvant radiation therapy demonstrated a 5-year LFS of 100%, compared to those who did not, 76.0% (p = 0.038).
  • CONCLUSION: Our results imply a potential role of LE and adjuvant radiation as an option for the treatment of distal rectal cancer, and that even for pT1 carcinoma, LE alone might not be a valid modality.
  • [MeSH-major] Rectal Neoplasms / radiotherapy. Rectal Neoplasms / surgery

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  • (PMID = 17571241.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
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31. Richetti A, Fogliata A, Clivio A, Nicolini G, Pesce G, Salati E, Vanetti E, Cozzi L: Neo-adjuvant chemo-radiation of rectal cancer with volumetric modulated arc therapy: summary of technical and dosimetric features and early clinical experience. Radiat Oncol; 2010;5:14
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  • [Title] Neo-adjuvant chemo-radiation of rectal cancer with volumetric modulated arc therapy: summary of technical and dosimetric features and early clinical experience.
  • BACKGROUND: To report about initial technical and clinical experience in preoperative radiation treatment of rectal cancer with volumetric modulated arcs with the RapidArc (RA) technology.
  • All showed locally advanced rectal adenocarcinoma with stage T2-T4, N0-1.
  • CONCLUSION: RA proved to be a safe, qualitatively advantageous treatment modality for rectal cancer, showing some improved results in dosimetric aspects.
  • [MeSH-major] Carcinoma / radiotherapy. Neoadjuvant Therapy / methods. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Intensity-Modulated / methods. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Capecitabine. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Female. Fluorouracil / analogs & derivatives. Fluorouracil / therapeutic use. Humans. Male. Middle Aged. Neoplasm Staging. Radiometry

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  • (PMID = 20170490.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2838920
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32. Kovacević D, Sonicki Z, Kusić Z, Bolanca A, Grubisić G, Lukac M, Lukac J: Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer. Int J Colorectal Dis; 2007 Jul;22(7):827-31
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  • [Title] Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer.
  • BACKGROUND AND AIM: Soluble c-erbB-2 oncoprotein has been proven as a useful marker in the management of breast cancer patients, but its value in diagnostics and follow-up of colorectal cancer patients remains controversial.
  • The aim of this study was to evaluate the usefulness of serum c-erbB-2 monitoring in diagnostics and prediction of disease outcome in rectal cancer patients.
  • MATERIALS AND METHODS: Serum samples from 88 patients with rectal adenocarcinoma before surgery and from 41 healthy controls were tested for the presence of c-erbB-2 oncoprotein by ELISA, and the patients were followed up for at least 5 years after the surgery.
  • Elevated preoperative serum c-erbB-2 levels showed relatively high specificity (88%) and low sensitivity (44%) in the diagnosis of rectal cancer.
  • CONCLUSION: Although preoperative serum c-erbB-2 levels were significantly higher in rectal cancer patients than in healthy controls, the soluble c-erbB-2 does not seem to be useful in the diagnosis of rectal cancer due to its low sensitivity.
  • Preoperative serum levels of this oncoprotein were predictive neither for overall survival nor for local recurrence/distant metastases in rectal cancer patients.
  • [MeSH-major] Adenocarcinoma / blood. Biomarkers, Tumor / blood. Colectomy. Receptor, ErbB-2 / blood. Rectal Neoplasms / blood

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  • [Cites] Oncol Rep. 1999 May-Jun;6(3):527-31 [10203586.001]
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  • (PMID = 17119985.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; EC 2.7.10.1 / Receptor, ErbB-2
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33. Sanchez LD, Chelliah T, Meisher I, Niranjan S: Rare case of breast tumor secondary to rectal adenocarcinoma. South Med J; 2008 Oct;101(10):1062-4
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  • [Title] Rare case of breast tumor secondary to rectal adenocarcinoma.
  • Primary breast cancer is the most common malignancy in women.
  • Metastatic cancer to the breast is very rare.
  • Colorectal cancers usually metastasize to the liver and the lung; other sites of metastasis from colon cancer are uncommon and are usually found in association with extensive liver and/or lung metastases.
  • This is a report of a rare case of aggressive rectal cancer with metastasis to the breast without liver or lung metastases.
  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / secondary. Rectal Neoplasms / pathology

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  • (PMID = 18791504.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Moparty B, Gomez G, Bhutani MS: Large solitary ovarian metastasis from colorectal cancer diagnosed by endoscopic ultrasound. World J Gastroenterol; 2008 Aug 28;14(32):5096-7
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  • [Title] Large solitary ovarian metastasis from colorectal cancer diagnosed by endoscopic ultrasound.
  • A case is presented of rectal carcinoma in which during staging by endoscopic ultrasound (EUS) a second large extrarectal mass was seen not otherwise visualized on computer tomography (CT) that was a solitary ovarian metastasis.
  • On retrospective review of the CT pelvis after surgery, the radiologist could still not diagnose the ovarian lesion separated from the primary rectal tumor due to their close proximity.
  • However, on EUS we were able to clearly see on real-time imaging that there was a distinct peri-rectal mass apart from the primary rectal tumor.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / ultrasonography. Colorectal Neoplasms / pathology. Ovarian Neoplasms / secondary. Ovarian Neoplasms / ultrasonography


35. Derin D, Eralp Y, Guney N, Ozlük Y, Topuz E: Ovarian carcinoma with simultaneous breast and rectum metastases. Onkologie; 2008 Apr;31(4):200-2
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  • [Title] Ovarian carcinoma with simultaneous breast and rectum metastases.
  • BACKGROUND: Metastatic involvement of the breast and the rectum from ovarian carcinoma are very rare events.
  • CASE REPORT: We report a case of ovarian carcinoma with metastasis to the breast and rectum simultaneously, 6 years after initial diagnosis.
  • RESULTS: Morphologic and immunohistochemical findings from pathologic samples of all involved sites confirmed the ovarian origin, which spared the patient unnecessary breast and rectal surgery.
  • To our knowledge, this is the first case of ovarian carcinoma with simultaneous metastases to the breast and rectum reported to date.
  • CONCLUSION: Accurate differential diagnosis from primary breast and rectal carcinoma is very important because the prognosis and treatment differ significantly.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / secondary. Cystadenocarcinoma, Papillary / pathology. Cystadenocarcinoma, Papillary / secondary. Ovarian Neoplasms / pathology. Rectal Neoplasms / pathology. Rectal Neoplasms / secondary

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  • [Copyright] 2008 S. Karger AG, Basel.
  • (PMID = 18418023.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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36. Lian P, Gu WL, Zhang Z, Cai GX, Wang MH, Xu Y, Sheng WQ, Cai SJ: Retrospective analysis of perianal Paget's disease with underlying anorectal carcinoma. World J Gastroenterol; 2010 Jun 21;16(23):2943-8
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  • [Title] Retrospective analysis of perianal Paget's disease with underlying anorectal carcinoma.
  • METHODS: PPD patients were retrospectively collected in the institutional colorectal database of the Fudan University Shanghai Cancer Center.
  • Detailed patient histories of past medical condition, diagnosis, treatment, and pathological findings were reviewed.
  • Surgical specimen from diagnosis and surgery were reviewed by two independent pathologists for confirmation of diagnoses.
  • All patients had underlying anorectal adenocarcinoma, including seven with synchronous lesions and one with metachronous lesions.
  • The median age at diagnosis was 65 (range 29-81 years), and the male/female ratio was 7:1.
  • Underlying anorectal cancer was not unusual and was a significant prognostic factor.
  • Rational treatment of both anorectal cancer and PPD lesion is essential for long-term survival.
  • [MeSH-major] Anus Neoplasms / diagnosis. Paget Disease, Extramammary / diagnosis. Rectal Neoplasms / diagnosis

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  • (PMID = 20556842.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2887592
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37. Lupattelli M, Maranzano E, Bellavita R, Natalini G, Corgna E, Rossetti R, Trippa F, Mascioni F, Sidoni A, Anselmo P, Buzzi F, Brugia M, Latini P: Raltitrexed and radiotherapy as adjuvant treatment for stage II-III rectal cancer: a feasibility study. Tumori; 2005 Nov-Dec;91(6):498-504
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  • [Title] Raltitrexed and radiotherapy as adjuvant treatment for stage II-III rectal cancer: a feasibility study.
  • AIMS AND BACKGROUND: Adjuvant 5-FU chemotherapy plus radiotherapy represents the standard treatment for radically resected rectal cancer at high risk of relapse according to the NIH Consensus Conference.
  • The aim of this prospective multicenter phase II study was to evaluate the feasibility, gastrointestinal and hematological acute toxicity of raltitrexed in combination with radiotherapy in rectal cancer patients.
  • METHODS: From September 2000 to June 2004, 50 patients with radically resected stage II-III rectal adenocarcinoma were treated.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Antimetabolites, Antineoplastic / therapeutic use. Quinazolines / therapeutic use. Rectal Neoplasms / drug therapy. Rectal Neoplasms / radiotherapy. Thiophenes / therapeutic use. Thymidylate Synthase / antagonists & inhibitors
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Drug Administration Schedule. Enzyme Inhibitors / therapeutic use. Feasibility Studies. Female. Humans. Male. Middle Aged. Neoplasm Staging. Patient Compliance. Prospective Studies. Radiotherapy Dosage. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 16457149.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Enzyme Inhibitors; 0 / Quinazolines; 0 / Thiophenes; EC 2.1.1.45 / Thymidylate Synthase; FCB9EGG971 / raltitrexed
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38. Zhou JN, Wang DZ, Huang XE, Xu FP, Shang JQ, Gu RM: Transabdominal transanal resection of distal rectal cancer after high dose preoperative radiotherapy: a Chinese experience in preserving sphincter function. Isr Med Assoc J; 2006 Oct;8(10):675-8
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  • [Title] Transabdominal transanal resection of distal rectal cancer after high dose preoperative radiotherapy: a Chinese experience in preserving sphincter function.
  • METHODS: From September 1994 to September 2000, 25 consecutive patients with pathologically confirmed distal rectal adenocarcinoma were treated preoperatively with a total dose of 45-46 Gy at 1.8-2.0 Gy per fraction during 5 weeks.
  • CONCLUSIONS: High dose preoperative radiotherapy and TATA as a sphincter-preserving method was feasible and efficient in Chinese patients with distal rectal cancer.
  • [MeSH-major] Abdomen / surgery. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Anal Canal / physiopathology. Anal Canal / surgery. Rectal Neoplasms / radiotherapy. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. China. Combined Modality Therapy / methods. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Postoperative Complications. Preoperative Care / methods. Radiation Injuries / etiology. Radiotherapy Dosage. Rectum / radiation effects. Rectum / surgery. Survival Analysis. Treatment Outcome

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  • [CommentIn] Isr Med Assoc J. 2006 Oct;8(10):711-2 [17125121.001]
  • (PMID = 17125111.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Israel
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39. Braat AE, Oosterhuis JW, Moll FC, de Vries JE, Wiggers T: Sentinel node detection after preoperative short-course radiotherapy in rectal carcinoma is not reliable. Br J Surg; 2005 Dec;92(12):1533-8
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  • [Title] Sentinel node detection after preoperative short-course radiotherapy in rectal carcinoma is not reliable.
  • BACKGROUND: Sentinel node (SN) detection may be used in patients with colonic carcinoma.
  • However, its use in patients with rectal carcinoma may be unreliable.
  • To address this, SN detection was evaluated in patients with rectal carcinoma after short-course preoperative radiotherapy.
  • In addition, SN detection was performed in 57 patients with colonic carcinoma.
  • RESULTS: A SN was identified in 26 of 34 patients with rectal carcinoma.
  • By contrast, SN detection was possible in 56 of 57 patient with colonic carcinoma with a sensitivity of 90 per cent, and four patients were upstaged.
  • CONCLUSION: The SN procedure for rectal carcinoma is not reliable in combination with TME and preoperative short-course radiotherapy.
  • [MeSH-major] Colonic Neoplasms / pathology. Rectal Neoplasms / pathology

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  • [Copyright] Copyright (c) 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 16231281.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Rosaniline Dyes; 129-17-9 / patent blue violet
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40. Bebenek M, Wojnar A: Infralevator lymphatic drainage of low-rectal cancers: preliminary results. Ann Surg Oncol; 2009 Apr;16(4):887-92
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  • [Title] Infralevator lymphatic drainage of low-rectal cancers: preliminary results.
  • BACKGROUND: Some low-rectal cancers may spread into or recur in the inguinal lymph nodes despite optimal resection of the primary tumor.
  • Hence, we hypothesized that lymphatic drainage of low-rectal malignancies may be inhomogeneous and that an extramesorectal route may be involved in at least some cases.
  • The idea of our preliminary study was to analyze the potential lymphatic drainages in low-rectal cancer patients.
  • METHODS: The first stage of the experiment included two consecutive low-rectal adenocarcinoma patients (free from inguinal lymph node metastases), in whom the lymphatics of the primary tumor were traced with Patentbalu dye.
  • During the second stage the records of 206 consecutive low-rectal cancer patients were analyzed for presence of inguinal lymph node metastases.
  • RESULTS: An evaluation of specimens from two rectal cancer patients revealed extramesorectal lymphatic drainage of the primary tumor besides the mesorectal route.
  • They were all diagnosed with rectal adenocarcinoma, T3 or T4 tumors with G2 or G3 grade.
  • CONCLUSION: The demonstration of an alternative route of lymphatic drainage suggests that more radical surgical procedures are necessary for successful treatment of low-rectal cancers.
  • [MeSH-major] Adenocarcinoma / pathology. Rectal Neoplasms / pathology

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  • (PMID = 19165544.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents
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41. Meguid RA, Slidell MB, Wolfgang CL, Chang DC, Ahuja N: Is there a difference in survival between right- versus left-sided colon cancers? Ann Surg Oncol; 2008 Sep;15(9):2388-94
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  • METHODS: A retrospective survival analysis was performed using the Surveillance, Epidemiology, and End Results Program (SEER) database between 1988 and 2003 on subjects who underwent surgical resection for the a primary diagnosis of pathologically confirmed invasive colon adenocarcinoma.
  • Cox proportional hazard regression analysis was used to assess long-term survival outcomes comparing right-sided (cecum to transverse colon, excluding appendix) versus left-sided (splenic flexure to sigmoid, excluding rectum) colon cancers.
  • RESULTS: A total of 77,978 subjects were identified with adenocarcinoma of the colon.
  • By Cox proportional hazard regression analysis, controlling for statistically significant confounders, including age, sex, race, marital status, tumor stage, tumor size, histologic grade, number of lymph nodes examined, and year of diagnosis, right-sided colon cancers were associated with a 5% increased mortality risk compared with left-sided colon cancers (hazard ratio, 1.04; 95% confidence interval, 1.02-1.07).

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  • (PMID = 18622647.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK007713-13; United States / NIDDK NIH HHS / DK / T32 DK007713; United States / NIDDK NIH HHS / DK / T32 DK007713-13; United States / NIDDK NIH HHS / DK / T32DK007713
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS280426; NLM/ PMC3072702
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42. Lidder PG, Hosie KB: Rectal cancer: the role of radiotherapy. Dig Surg; 2005;22(1-2):41-8; discussion 49
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  • [Title] Rectal cancer: the role of radiotherapy.
  • Surgery is the definitive tool in the management of patients with rectal carcinoma.
  • This article examines the role of radiotherapy in the management of patients with rectal carcinoma and explores the controversies that exist in its application.
  • [MeSH-major] Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Humans. Neoadjuvant Therapy. Neoplasm Recurrence, Local. Palliative Care. Radiotherapy Dosage. Radiotherapy, Adjuvant

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  • (PMID = 15838170.001).
  • [ISSN] 0253-4886
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 45
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43. Okabayashi K, Hasegawa H, Ishii Y, Endo T, Kitagawa Y: Adenosquamous carcinoma of the sigmoid colon treated by the less invasive procedures of endoscopy and laparoscopy: report of a case. Surg Today; 2009;39(11):994-7
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  • [Title] Adenosquamous carcinoma of the sigmoid colon treated by the less invasive procedures of endoscopy and laparoscopy: report of a case.
  • Although this polyp was suspected of invading the submucosal layer, it was removed endoscopically because the preoperative diagnosis was well-differentiated adenocarcinoma.
  • The pathological findings revealed adenosquamous carcinoma that had invaded the submucosal layer with lymphatic invasion.
  • Adenosquamous carcinoma has been reported to be rare and to possess a highly metastatic potential.
  • We report a case of adenosquamous carcinoma of the sigmoid colon treated by less invasive approaches consisting of an endoscopic mucosal resection and a subsequent laparoscopic colectomy.
  • [MeSH-major] Carcinoma, Adenosquamous / surgery. Colectomy / methods. Colon, Sigmoid / surgery. Colonoscopy / methods. Laparoscopy / methods. Sigmoid Neoplasms / surgery

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  • (PMID = 19882324.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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44. Yamamoto S, Fujita S, Akasu T, Moriya Y: Safety of laparoscopic intracorporeal rectal transection with double-stapling technique anastomosis. Surg Laparosc Endosc Percutan Tech; 2005 Apr;15(2):70-4
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  • [Title] Safety of laparoscopic intracorporeal rectal transection with double-stapling technique anastomosis.
  • To assess the feasibility and analyze the short-term outcomes of laparoscopic intracorporeal rectal transection with double-stapling technique anastomosis, a review was performed of a prospective registry of 67 patients who underwent laparoscopic sigmoidectomy and anterior resection with intracorporeal rectal transection and double-stapling technique anastomosis between July 2001 and January 2004.
  • Patients were divided into 3 groups: sigmoid colon/rectosigmoid carcinoma, upper rectal carcinoma, and middle/lower rectal carcinoma.
  • The number of cartridges required in bowel transection was significantly increased in patients with middle/lower rectal carcinoma, and significant differences were observed in the length of the first stapler cartridge fired for rectal transection.
  • Furthermore, mean operative time and blood loss were also significantly greater in the middle/lower rectum group; however, complication rates and postoperative course were similar among the 3 groups.
  • Laparoscopic intracorporeal rectal transection with double-stapling technique anastomosis can be performed safely without increased morbidity or mortality.
  • [MeSH-major] Anastomosis, Surgical / methods. Carcinoma / surgery. Colorectal Neoplasms / surgery. Laparoscopy / adverse effects. Rectum / surgery. Surgical Stapling / methods

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  • (PMID = 15821617.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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45. Rafailidis SF, Ballas KD, Symeonidis N, Pavlidis TE, Emoniotou E, Psarras K, Pantzaki A, Marakis GN, Sakadamis AK: Pelvic malakoplakia simulating recurrence of rectal adenocarcinoma: report of a case. Tech Coloproctol; 2009 Mar;13(1):79-81
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  • [Title] Pelvic malakoplakia simulating recurrence of rectal adenocarcinoma: report of a case.
  • Rarity of the disease and wide variety of clinical presentation makes its diagnosis very challenging.
  • We report herein the case of a 66-year-old woman who, having undergone lower anterior resection for rectal adenocarcinoma 3 and a half years ago, presented with urinary frequency and dull abdominal pain.
  • CT scan revealed a soft tissue tumour infiltrating the preperitoneal fat over the urinary bladder, which was considered as recurrence of the rectal carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Malacoplakia / diagnosis. Neoplasm Recurrence, Local / diagnosis. Pelvis / pathology. Rectal Neoplasms / surgery
  • [MeSH-minor] Aged. Colonoscopy. Diagnosis, Differential. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 18679567.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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46. Zhang W, Ho KS, Han HJ, Kong CS, Eu KW: Successful resuscitation after carbon dioxide embolism during laparoscopic-assisted abdomino-perineal resection. Singapore Med J; 2005 Jul;46(7):347-8
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  • We report a 67-year-old woman who underwent laparoscopic-assisted abdomino-perineal resection for rectal carcinoma.
  • [MeSH-minor] Aged. Carbon Dioxide. Female. Humans. Laparoscopy. Posture. Rectal Neoplasms / surgery

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  • (PMID = 15968448.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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47. Kelley ST, Coppola D, Yeatman T, Marcet J: Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways. Clin Colorectal Cancer; 2005 Jul;5(2):114-8
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  • [Title] Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways.
  • BACKGROUND: We tested the hypothesis that rectal tumors are most responsive to neoadjuvant therapy if they possess p53 and/or caspase 8 activity.
  • PATIENTS AND METHODS: Fifty patients diagnosed with biopsy-proven rectal cancer underwent neoadjuvant chemoradiation therapy consisting of 5-fluorouracil (300 mg/m(2) daily) and radiation (4,500 cGy).
  • Endorectal ultrasonography was performed before and after neoadjuvant therapy along with digital rectal examination and/or sigmoidoscopy for staging purposes and to evaluate response to therapy.
  • There were 10 stage I tumors (20%), 22 stage II tumors (44%), and 18 stage III tumors (36%) in the cohort at the time of initial diagnosis. p53 protein staining (ie, mutated p53) was positive in 31 tumors (62%; CR, n = 8; PR, n = 11; NR, n = 12); caspase 8 positivity was apparent in 30 specimens (60%; CR, n = 13; PR, n = 13; NR, n = 4).
  • [MeSH-major] Adenocarcinoma / therapy. Caspases / metabolism. Neoadjuvant Therapy. Rectal Neoplasms / therapy. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 16098252.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Biomarkers; 0 / Tumor Suppressor Protein p53; EC 3.4.22.- / CASP8 protein, human; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspases; U3P01618RT / Fluorouracil
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48. Bertelsen CA, Andreasen AH, Jørgensen T, Harling H, Danish Colorectal Cancer Group: Anastomotic leakage after curative anterior resection for rectal cancer: short and long-term outcome. Colorectal Dis; 2010 Jul;12(7 Online):e76-81
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  • [Title] Anastomotic leakage after curative anterior resection for rectal cancer: short and long-term outcome.
  • OBJECTIVE: The influence of symptomatic anastomotic leakage (AL) after anterior resection (AR) for rectal cancer on short and long-term mortality and local and distant recurrence was analysed.
  • METHOD: All patients with a first diagnosis of rectal carcinoma were prospectively registered in a national database.
  • CONCLUSION: Anastomotic leakage after AR for rectal cancer increases the 30-day and long-term mortality, but AL did not increase the risk of local and distant recurrence.
  • [MeSH-major] Colectomy / adverse effects. Rectal Neoplasms / surgery. Rectum / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anastomosis, Surgical / adverse effects. Anastomosis, Surgical / mortality. Denmark / epidemiology. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Postoperative Complications. Prognosis. Prospective Studies. Risk Factors. Survival Rate / trends. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 19438879.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Investigator] Gustafsen J; Wille-Jorgensen P; Bülow S; Wied U; Raskov HH; Crone P; Ronholt C; Hansen OH; Jess P; Kirkeby L; Iversen E; Haakansson T; Andersen OB; Nymark J; Lawaetz O; Rahr H; Madsen P; V Andersen P; Buch N; Teglaard P; Jensen KE; Berg V; Thomsen H; Klaerke M; Bisgaard C; Sloth H; Madsen MR; Madsen G; Christensen H; Nielsen JD; Mark M; Lausten-Thomsen HH; Nord S; Gandrup P; Lauesen N; Lundhus E; Malling N
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49. Kersting S, Bruewer M, Laukoetter MG, Rijcken EM, Mennigen R, Buerger H, Senninger N, Krieglstein CF: Intestinal cancer in patients with Crohn's disease. Int J Colorectal Dis; 2007 Apr;22(4):411-7
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  • [Title] Intestinal cancer in patients with Crohn's disease.
  • BACKGROUND: Surveillance of intestinal cancer in Crohn's disease (CD) has often been advocated.
  • To date, no clear evidence exists whether CD patients are at special risk for intestinal cancer.
  • An increased incidence of small bowel adenocarcinoma is suggested.
  • However, recent figures also suggest an increased risk of CD associated colorectal cancer.
  • We report our experience with 10 cases of CD complicated by intestinal adenocarcinoma.
  • Data of patients that developed carcinoma within Crohn's lesions of either small or large bowel were analyzed.
  • RESULTS: Ten patients were diagnosed with CD complicated by carcinoma.
  • In nine patients, cancer was present in the colorectum and in one, in Crohn's ileitis.
  • Mean age at the time of diagnosis of CD was 43 years.
  • Mean duration of CD until diagnosis of cancer was 14 years.
  • Only five patients were diagnosed for cancer preoperatively.
  • CONCLUSIONS: Cancer risk in CD and especially in Crohn's colitis may still be underestimated.
  • Delayed diagnosis resulted in a poor prognosis.
  • The value of colonoscopy as surveillance tool is questioned by the fact that in our patients, carcinoma was diagnosed in some patients preoperatively by routine colonoscopy.

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  • (PMID = 16847674.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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50. Kume S, Kubota T, Takahashi M, Hashimoto D, Hirata T, Torigoe Y, Ikeda O: [A case of locally advanced rectal cancer responding to FOLFOX]. Gan To Kagaku Ryoho; 2009 Apr;36(4):659-61
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  • [Title] [A case of locally advanced rectal cancer responding to FOLFOX].
  • The 57-year-old man was underwent sigmoid colostomy due to unresectable rectal carcinoma.
  • Preoperative chemotherapy with FOLFOX appears a promising regimen for patients with unresectable rectal cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Rectal Neoplasms / drug therapy. Rectal Neoplasms / pathology
  • [MeSH-minor] Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Organoplatinum Compounds / therapeutic use. Proctoscopy

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  • (PMID = 19381043.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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51. Wu ZY, Wan J, Li JH, Zhao G, Peng L, Yao Y, Du JL, Liu QF, Wang ZD, Huang ZM, Lin HH: Study of circumferential resection margin in patients with middle and lower rectal carcinoma. World J Gastroenterol; 2007 Jun 28;13(24):3380-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Study of circumferential resection margin in patients with middle and lower rectal carcinoma.
  • AIM: To clarify the relationship between circumferential resection margin status and local and distant recurrence as well as survival of patients with middle and lower rectal carcinoma.
  • The relationship between circumferential resection margin status and clinicopathologic characteristics of middle and lower rectal carcinoma was also evaluated.
  • METHODS: Cancer specimens from 56 patients with middle and lower rectal carcinoma who received total mesorectal excision at the Department of General Surgery of Guangdong Provincial People's Hospital were studied.
  • RESULTS: Local recurrence occurred in 12.5% (7 of 56 cases) of patients with middle and lower rectal carcinoma.
  • Distant recurrence occurred in 25% (14 of 56 cases) of patients with middle and lower rectal carcinoma.
  • In 18 cancer specimens with tumor diameter >= 5 cm 7 (38.9%) were detected as positive circumferential resection margin, while in 38 cancer specimens with a tumor diameter of < 5 cm only 5 (13.2%) were positive for circumferential resection margin (P = 0.028).
  • The circumferential resection margin status is an important predictor of local and distant recurrence as well as survival of patients with middle and lower rectal carcinoma.
  • [MeSH-major] Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 17659680.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4172721
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52. Radonak J, Lakyová L, Toporcer T: [Uncommon rectal adenocarcinoma metastases]. Rozhl Chir; 2010 Aug;89(7):441-5
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  • [Title] [Uncommon rectal adenocarcinoma metastases].
  • [Transliterated title] Nezvycajné metastazovanie adenokarcinómu rekta.
  • Rectal cancer treatment has become multimodal as a result of significant advances in imaging diagnostic, in surgery technique of re section and in neo and adjuvant therapy.
  • The aim of the case report was to present a successfully treated adenocarcinoma recti and adenocarcinoma of hepatal flexurae with recidivistic metastasis and an extremely rare intergrowth of the metastasis into venous system.
  • A 61 year old patient underwent low resection of recti according to Dixon because of well differentiated adenocarcinoma with classification T3N0M0.
  • The patient was reoperated because of metastasis of adenocarcinoma in the abdominal wall (16 x 15 x 20 cm) after chemotherapy (FUL-5-fluorouracyl) and radiation dose of 50.4 Gy.
  • 26 months after the first operation, a new sessile polyp was found in the hepatal flexurae with histological finding of well differentiated adenocarcinoma.
  • [MeSH-major] Abdominal Neoplasms / secondary. Abdominal Wall. Adenocarcinoma / secondary. Rectal Neoplasms / pathology

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  • (PMID = 20925261.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] slo
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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53. Zbar AP, Bernstein S, Greaves N, Iniss M, Shenoy RK: The utilization of intraluminal formalin for intractable rectal haemorrhage in advanced rectal cancer: a case report. Tech Coloproctol; 2005 Apr;9(1):49-51
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  • [Title] The utilization of intraluminal formalin for intractable rectal haemorrhage in advanced rectal cancer: a case report.
  • A patient with a metastatic fixed low rectal carcinoma presented severe rectal bleeding requiring massive transfusion over with a 36-hour period.
  • This technique has been reserved for intractable transfusion-dependent radiation proctitis and is presented as a primary alternative in severe rectal bleeding from inoperable rectal cancer.
  • [MeSH-major] Formaldehyde / therapeutic use. Gastrointestinal Hemorrhage / therapy. Rectal Neoplasms / complications
  • [MeSH-minor] Administration, Rectal. Adult. Female. Humans

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  • (PMID = 15868500.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 1HG84L3525 / Formaldehyde
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54. Cioffi U, De Simone M, Ferrero S, Ciulla MM, Lemos A, Avesani EC: Synchronous adenocarcinoma and carcinoid tumor of the terminal ileum in a Crohn's disease patient. BMC Cancer; 2005;5:157
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  • [Title] Synchronous adenocarcinoma and carcinoid tumor of the terminal ileum in a Crohn's disease patient.
  • BACKGROUND: Several malignancies have been described in association with inflammatory bowel diseases, the most common being adenocarcinoma.
  • Carcinoid tumor and Crohn disease has also been previously reported, however the coexistence of both neoplasms is quite rare and the clinical diagnosis is very difficult.
  • [MeSH-major] Adenocarcinoma / complications. Carcinoid Tumor / complications. Crohn Disease / complications. Ileal Neoplasms / complications. Neoplasms, Second Primary / diagnosis


55. Soumarová R, Skrovina M, Machala S, Adamcík L, Bartos J: [Intraoperative radiotherapy in multimodality treatment of locally advanced rectal carcinoma]. Rozhl Chir; 2010 Nov;89(11):685-8
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  • [Title] [Intraoperative radiotherapy in multimodality treatment of locally advanced rectal carcinoma].
  • [Transliterated title] Intraoperacní radioterapie v multimodalitní lécbe lokálne pokrocilého karcinomu rekta.
  • Multimodality treatment of locally advanced rectal cancer combines radical surgery, radiotherapy and chemotherapy.
  • [MeSH-major] Rectal Neoplasms / radiotherapy

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  • (PMID = 21409803.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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56. Petrie N, Branagan G, McGuiness C, McGee S, Fuller C, Chave H: Reconstruction of the perineum following anorectal cancer excision. Int J Colorectal Dis; 2009 Jan;24(1):97-104
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  • [Title] Reconstruction of the perineum following anorectal cancer excision.
  • PURPOSE: Most patients with anal cancer receive chemoradiotherapy as first-line treatment.
  • A proportion of the 20,000 new cases of rectal carcinoma diagnosed in the UK each year receive neo-adjuvant chemoradiation and then an APR.
  • This study investigates a series of 18 patients who underwent APR for anorectal cancer with flap reconstruction of their perineum.
  • RESULTS: Between November 2000 and October 2007, 18 cases were performed (M/F = 7:11), six for anal cancer and 12 for low rectal tumours.
  • [MeSH-major] Perineum / surgery. Rectal Neoplasms / therapy. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma / therapy. Chemotherapy, Adjuvant. Cohort Studies. Female. Humans. Length of Stay. Male. Middle Aged. Neoadjuvant Therapy. Postoperative Complications. Radiotherapy, Adjuvant. Retrospective Studies. Wound Healing

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  • (PMID = 18688618.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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57. Ishiyama S, Inoue S, Kobayashi K, Sano Y, Kushida N, Yamazaki Y, Yanaga K: Implantation of rectal cancer in an anal fistula: report of a case. Surg Today; 2006;36(8):747-9
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  • [Title] Implantation of rectal cancer in an anal fistula: report of a case.
  • Barium enema and colonoscopy confirmed advanced rectal cancer and we palpated a soft tumor, 3 cm in diameter, with inflammatory induration on the right side of the rectum.
  • Histological examination of the perianal necrotic tissue obtained during resection of the perianal tumor encompassing the anal fistula revealed adenocarcinoma.
  • Since the histology of the perianal lesion was identical to that of the rectal cancer, a diagnosis of cancer implantation rather than carcinoma originating in the anal fistula was entertained.
  • Although the recurrence of rectal cancer by mucosal implantation is not uncommon, the coincidental implantation of rectal cancer in an anal fistula is extremely rare.
  • [MeSH-major] Adenocarcinoma / pathology. Anus Neoplasms / pathology. Neoplasm Seeding. Rectal Fistula / complications. Rectal Neoplasms / pathology


58. Sprenger T, Rothe H, Langer C, Becker H, Liersch T: Comment on "lymph nodes after preoperative chemoradiotherapy for rectal carcinoma: number, status, and impact on survival". Am J Surg Pathol; 2009 Jul;33(7):1107; author reply 1108
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  • [Title] Comment on "lymph nodes after preoperative chemoradiotherapy for rectal carcinoma: number, status, and impact on survival".
  • [MeSH-major] Adenocarcinoma / pathology. Lymphatic Metastasis / pathology. Rectal Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Humans. Lymph Nodes / pathology. Neoadjuvant Therapy. Neoplasm Staging. Radiotherapy

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  • [CommentOn] Am J Surg Pathol. 2008 Jan;32(1):45-50 [18162769.001]
  • (PMID = 19390426.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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59. Nicholls J: Local excision of rectal carcinoma. Colorectal Dis; 2007 Nov;9(9):771-2
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  • [Title] Local excision of rectal carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma / surgery. Rectal Neoplasms / surgery

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  • (PMID = 17931167.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] England
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60. Jeyarajah S, Sutton CD, Miller AS, Hemingway D, Leicester Colorectal Specialist Group: Factors that influence the adequacy of total mesorectal excision for rectal cancer. Colorectal Dis; 2007 Nov;9(9):808-15
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  • [Title] Factors that influence the adequacy of total mesorectal excision for rectal cancer.
  • OBJECTIVE: In 1997 with the start of CRO7 trial it was agreed that adequacy of surgical resection of rectal cancer would be determined by a pathologically determined grading of the mesorectum the so called total mesorectal excision score (TME score).
  • METHOD: Data on all patients undergoing resectional surgery for rectal cancer in our unit are entered prospectively onto a database.
  • RESULTS: Between January 2000 and June 2005, 518 patients underwent surgery for adenocarcinoma of the rectum, of these, 287 patients had a total mesorectal excision for mid or lower third tumours under the care of seven colorectal surgeons.
  • CONCLUSION: There is no relationship between the TME score in patients undergoing resectional surgery for adenocarcinoma of the rectum and the development of local recurrence at 2 years.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Neoplasm Recurrence, Local. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Rectum / surgery. Survival Analysis. Treatment Outcome

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  • [CommentIn] Colorectal Dis. 2008 Jul;10(6):629; author reply 629-30 [18533007.001]
  • (PMID = 17441969.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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61. Ngan SY, Fisher R, Burmeister BH, Mackay J, Goldstein D, Kneebone A, Schache D, Joseph D, McKendrick J, Leong T, McClure B, Rischin D: Promising results of a cooperative group phase II trial of preoperative chemoradiation for locally advanced rectal cancer (TROG 9801). Dis Colon Rectum; 2005 Jul;48(7):1389-96
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  • [Title] Promising results of a cooperative group phase II trial of preoperative chemoradiation for locally advanced rectal cancer (TROG 9801).
  • PURPOSE: This article reports the overall survival, failure-free survival, local failure, and late radiation toxicity of a phase II trial of preoperative radiotherapy with continuous infusion 5-fluorouracil for rectal cancer after a minimum 3.5 years of follow-up.
  • METHODS: Eligible patients were those with newly diagnosed localized adenocarcinoma of the rectum, within 12 cm of the anal verge, staged T3-T4 and deemed suitable for curative resection.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Fluorouracil / therapeutic use. Rectal Neoplasms / drug therapy. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Dose Fractionation. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy Dosage. Survival Rate. Treatment Outcome

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  • (PMID = 15906126.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] U3P01618RT / Fluorouracil
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62. Moraes Rda S, Malafaia O, Telles JE, Trippia MA, Buess GF, Coelho JC: [Transanal endoscopic microsurgery in the treatment of rectal tumors: a prospective study in 50 patients]. Arq Gastroenterol; 2008 Oct-Dec;45(4):268-74
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  • [Title] [Transanal endoscopic microsurgery in the treatment of rectal tumors: a prospective study in 50 patients].
  • BACKGROUND: The medical literature accepts local resection as a valuable option in selected cases of rectal tumors.
  • METHODS: From April 2002 to April 2006, 50 patients with rectal tumors were submitted to transanal endoscopic microsurgery, chosen by clinical history and lesion characteristics.
  • The inclusion criteria were: sessile adenomas larger than 3 cm and smaller than 8 cm, not circumferentially distributed; intra epithelial neoplasia of high degree; and rectal carcinoma pT1, and special cases of pT2.
  • All these rectal tumors were submitted to the same surgical act.
  • RESULTS: The final histopathological results reveal 9 adenoma, 26 intra-epithelial neoplasia of high degree, 13 carcinoma (9 pT1-4 pT2) and 2 carcinoid.
  • One patient with low risk carcinoma pT1 presented recurrence 18 months after transanal endoscopic microsurgery and was submitted to curative rectosigmoidectomy.
  • It was proven a residual tumor after local surgery in two patients and the most important complication was one recto-vaginal fistula.
  • CONCLUSION: Today transanal endoscopic microsurgery is chosen as the ideal technique for the treatment of sessile adenomas, intraepithelial neoplasia of high degree and rectal carcinoma pT1.
  • [MeSH-major] Adenoma / surgery. Carcinoma / surgery. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasm, Residual. Prospective Studies. Treatment Outcome

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  • (PMID = 19148353.001).
  • [ISSN] 1678-4219
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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63. Wu TJ, Yeh CN, Chao TC, Jan YY, Chen MF: Prognostic factors of primary small bowel adenocarcinoma: univariate and multivariate analysis. World J Surg; 2006 Mar;30(3):391-8; discussion 399
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  • [Title] Prognostic factors of primary small bowel adenocarcinoma: univariate and multivariate analysis.
  • BACKGROUND: Adenocarcinoma of the small bowel is relatively less common than malignancies of the esophagus, stomach, and colorectum.
  • In small bowel adenocarcinoma, various prognostic factors influence the disease-free status and overall survival rates.
  • MATERIALS AND METHODS: Eighty patients who were diagnosed with small bowel adenocarcinoma and treated at our institute between 1983 and 2003 were retrospectively reviewed.
  • CONCLUSIONS: Poor prognosis of small bowel adenocarcinoma may be related to a delay in the diagnosis and treatment of the disease.
  • Curative resection is the aim of surgical treatment for small bowel adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Intestinal Neoplasms / pathology. Intestine, Small
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Disease-Free Survival. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local. Predictive Value of Tests. Prognosis. Proportional Hazards Models. Survival Rate

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  • (PMID = 16479330.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Roh YH, Lee HW, Kim MC, Lee KW, Roh MS: Collision tumor of the rectum: a case report of metastatic gastric adenocarcinoma plus primary rectal adenocarcinoma. World J Gastroenterol; 2006 Sep 14;12(34):5569-72
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  • [Title] Collision tumor of the rectum: a case report of metastatic gastric adenocarcinoma plus primary rectal adenocarcinoma.
  • We report here a highly unusual case of a 61-year old man who had a unique tumor that was composed of a metastatic adenocarcinoma from the stomach to the rectum, which harbored a collision tumor of primary rectal adenocarcinoma.
  • The clonalities of the two histologically distinct lesions of the rectal mass were confirmed by immunohistochemical and molecular analysis.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Rectal Neoplasms / pathology. Rectal Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 17007003.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4088248
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65. Appu S, Lawrentschuk N, Russell JM, Bright NF: Metachronous metastasis to the penis from carcinoma of the rectum. Int J Urol; 2006 May;13(5):659-61
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  • [Title] Metachronous metastasis to the penis from carcinoma of the rectum.
  • Furthermore, very few cases exist where primary rectal carcinoma metastasising to the penis has been reported.
  • [MeSH-major] Adenocarcinoma / pathology. Penile Neoplasms / pathology. Penile Neoplasms / secondary. Rectal Neoplasms / pathology

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  • (PMID = 16771752.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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66. Morino M, Rimonda R, Allaix ME, Giraudo G, Garrone C: Ultrasonic versus standard electric dissection in laparoscopic colorectal surgery: a prospective randomized clinical trial. Ann Surg; 2005 Dec;242(6):897-901, discussion 901
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  • The diagnosis of the remaining 146 patients was diverticulitis (44), colonic adenoma (31), adenocarcinoma (70), or epidermoid carcinoma (1).

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  • (PMID = 16327500.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1409879
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67. Cui CY, Li L, Liu LZ: [Value of multislice spiral CT in preoperative staging of rectal carcinoma]. Ai Zheng; 2008 Feb;27(2):196-200
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  • [Title] [Value of multislice spiral CT in preoperative staging of rectal carcinoma].
  • BACKGROUND & OBJECTIVE: Preoperative staging is important for optimal therapy planning and prognosis prediction of rectal carcinoma.
  • The role of conventional computed tomography (CT) in preoperative staging of rectal carcinoma is controversial.
  • This study was to evaluate the value of multislice spiral computed tomography (MSCT) in preoperative staging of rectal carcinoma.
  • 2007, 87 patients with pathologically proved rectal cancer underwent preoperative plain and enhanced MSCT.
  • Two radiologists evaluated independently tumor location, size, the depth of tumor invasion into the rectal wall (T), the involvement of regional lymph nodes (N) and the presence of distant metastases (M) on CT images.
  • RESULTS: All the 87 cases of rectal carcinoma were detected clearly by MSCT.
  • CONCLUSION: MSCT is an accurate technique for preoperative staging of rectal carcinoma, which can assess the extension to adjacent tissues and the presence of lymph node and distant metastases exactly.
  • [MeSH-major] Rectal Neoplasms / pathology. Rectal Neoplasms / radiography. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 18279621.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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68. Edino ST, Mohammed AZ, Ochicha O: Characteristics of colorectal carcinoma in Kano, Nigeria: an analysis of 50 cases. Niger J Med; 2005 Apr-Jun;14(2):161-6
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  • [Title] Characteristics of colorectal carcinoma in Kano, Nigeria: an analysis of 50 cases.
  • BACKGROUND: Several recent publications have shown a rising incidence with high morbidity and mortality of colorectal cancer amongst blacks.
  • The aim of this study was to determine the epidemiological profile of the colorectal carcinoma in our hospital, a major referral centre in northwestern Nigeria.
  • METHODOLOGY: A retrospective analysis of all histologically proven cases of colorectal carcinoma was performed from January 1999 to December 2002.
  • Carcinoma of the colon occurred in 22 (44%) patients and rectal carcinoma in 28 (56%) patients.
  • Twenty (71.4%) of the 28 rectal cancers were digitally palpable.
  • Adenocarcinoma was the only histologic type, with 15 (30%) cases of the mucinous variety.
  • Any adult with complaints of vague abdominal pain, blood or mucus in the stool or features of haemorrhoids which may herald the onset of colorectal cancer should be adequately investigated with digital rectal examination (DRE) and proctosigmoidoscopy and barium enema where appropriate.
  • [MeSH-major] Adenocarcinoma / epidemiology. Colorectal Neoplasms / epidemiology

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  • (PMID = 16083239.001).
  • [ISSN] 1115-2613
  • [Journal-full-title] Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria
  • [ISO-abbreviation] Niger J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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69. Zhao DB, Gao JD, Bi JJ, Shao YF, Zhao P: [Lymph node metastasis and prognosis in T1 and T2 rectal carcinoma]. Zhonghua Zhong Liu Za Zhi; 2006 Mar;28(3):235-7
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  • [Title] [Lymph node metastasis and prognosis in T1 and T2 rectal carcinoma].
  • OBJECTIVE: To investigate the characteristics of lymph node metastasis and prognosis of T1/T2 rectal carcinoma.
  • METHODS: The clinical data of 241 patients with T1 or T2 rectal carcinoma were retrospectively analyzed.
  • CONCLUSION: Even though lymph node metastasis can be observed either in T1 or T2 rectal carcinoma, histological differentiation is significantly related to the lymph node metastasis.
  • As radical resection achieve better survival than local resection, it should be suggested as the chief treatment for T1/T2 rectal carcinoma.
  • [MeSH-major] Carcinoma, Ductal / surgery. Lymph Nodes / pathology. Rectal Neoplasms / surgery. Rectum / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / radiotherapy. Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate

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  • (PMID = 16875615.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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71. Cappell MS, Batke M: Invasive cancer in a diminutive rectal polyp amidst internal hemorrhoids detected by rectal retroflexion. South Med J; 2010 Sep;103(9):943-6
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  • [Title] Invasive cancer in a diminutive rectal polyp amidst internal hemorrhoids detected by rectal retroflexion.
  • A diminutive rectal polyp amidst internal hemorrhoids, detected by rectal retroflexion during colonoscopy, was shown to harbor invasive rectal adenocarcinoma by colonoscopic biopsy.
  • Initially this lesion had appeared to be a relatively innocuous prominent anorectal mucosal fold and was recognized as a diminutive polyp only after careful rectal retroflexion during colonoscopy.
  • This report emphasizes that lesions just above the anorectal junction with atypical endoscopic features for internal hemorrhoids should be carefully examined at rectal retroflexion and that polyps or suspicious lesions amidst internal hemorrhoids identified during colonoscopy should be snared or at least biopsied, even if small.
  • This case report also illustrates how easily an early cancer in a diminutive colonic polyp can be missed when in difficult areas of colonoscopic inspection, such as behind a colonic fold or immediately above the anus.
  • [MeSH-major] Adenocarcinoma / diagnosis. Colonoscopy. Hemorrhoids / pathology. Intestinal Polyps / pathology. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Early Diagnosis. Humans. Male. Middle Aged. Neoplasm Invasiveness. Rectum / pathology

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  • (PMID = 20689479.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Lohsiriwat V, Boonnuch W, Suttinont P: Esophageal metastasis from rectal carcinoma. J Clin Gastroenterol; 2005 Sep;39(8):744
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  • [Title] Esophageal metastasis from rectal carcinoma.
  • [MeSH-major] Adenocarcinoma / complications. Esophageal Neoplasms / secondary. Rectal Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Endoscopy, Gastrointestinal. Humans. Male

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  • (PMID = 16082290.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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73. Marín García D, Cárdenas Lafuente F, Utrilla Ayala Mdel C, Galán Jurado MV, Jiménez Martín JJ, García Ordóñez MA: [Primary diffuse large B-cell lymphoma of the rectum simulating a rectal adenocarcinoma]. Gastroenterol Hepatol; 2010 Feb;33(2):92-8
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  • [Title] [Primary diffuse large B-cell lymphoma of the rectum simulating a rectal adenocarcinoma].
  • [Transliterated title] Linfoma de tipo B difuso de células grandes primario rectal que simula un adenocarcinoma de recto.
  • Dawson's criteria are highly useful in the differential diagnosis between primary colorectal involvement and gastrointestinal tract involvement secondary to systemic lymphoma, which is important due to the distinct prognosis and treatment of these entities.
  • [MeSH-major] Adenocarcinoma / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonoscopy. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Doxorubicin / therapeutic use. Humans. Immunohistochemistry. Male. Meta-Analysis as Topic. Middle Aged. Neoplasm Staging. Prednisone / therapeutic use. Prognosis. Radiography, Abdominal. Rectum / pathology. Tomography, X-Ray Computed. Vincristine / therapeutic use

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  • [Copyright] Copyright 2009 Elsevier España, S.L. All rights reserved.
  • (PMID = 19875198.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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74. Kobayashi N, Hata N, Yokoyama S, Shinada T, Shirakabe A, Mizuno K: A case of Takotsubo cardiomyopathy during 5-fluorouracil treatment for rectal adenocarcinoma. J Nippon Med Sch; 2009 Feb;76(1):27-33
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  • [Title] A case of Takotsubo cardiomyopathy during 5-fluorouracil treatment for rectal adenocarcinoma.
  • Acute heart failure developed during the administration of 5-fluorouracil (5-FU) and levofolinate calcium in a 62-year-old woman who had underwent a Miles operation for rectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / adverse effects. Fluorouracil / adverse effects. Rectal Neoplasms / drug therapy. Takotsubo Cardiomyopathy / chemically induced

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  • (PMID = 19305108.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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75. Portaluri M, Bambace S, Perez C, Angone G: A three-dimensional definition of nodal spaces on the basis of CT images showing enlarged nodes for pelvic radiotherapy. Int J Radiat Oncol Biol Phys; 2005 Nov 15;63(4):1101-7
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  • METHODS AND MATERIALS: Twenty consecutive patients (16 males, 4 females; mean age, 66 years; range, 43-80 years) with radiologic diagnosis of nodal involvement by histologically proved cervix carcinoma (two), rectum carcinoma (three), prostate carcinoma (four), lymphoma (five), penis carcinoma (one), corpus uteri carcinoma (one), bladder carcinoma (two), cutis tumor (one), and soft-tissue sarcoma (one) were retrospectively reviewed.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis / radiography. Male. Middle Aged. Pelvis. Penile Neoplasms / radiography. Penile Neoplasms / radiotherapy. Prostatic Neoplasms / radiography. Prostatic Neoplasms / radiotherapy. Rectal Neoplasms / radiography. Rectal Neoplasms / radiotherapy. Retrospective Studies. Tomography, X-Ray Computed. Uterine Neoplasms / radiography. Uterine Neoplasms / radiotherapy

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  • (PMID = 15913911.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Perez RO, Habr-Gama A, Nishida Arazawa ST, Rawet V, Coelho Siqueira SA, Kiss DR, Gama-Rodrigues JJ: Lymph node micrometastasis in stage II distal rectal cancer following neoadjuvant chemoradiation therapy. Int J Colorectal Dis; 2005 Sep;20(5):434-9
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  • [Title] Lymph node micrometastasis in stage II distal rectal cancer following neoadjuvant chemoradiation therapy.
  • OBJECTIVE: The objective was to determine the presence and frequency of micrometastasis in lymph nodes of patients with rectal cancer treated by preoperative chemoradiation followed by curative resection.
  • PATIENTS AND METHODS: All 56 patients included were treated with 5-FU and leucovorin plus 5,040 cGy, followed by radical surgery and were diagnosed with stage II distal rectal adenocarcinoma after complete pathological examination (ypT3-4N0M0).
  • There were two cancer-related deaths.
  • CONCLUSION: Patients with rectal cancer treated by preoperative chemoradiation showed a surprisingly low rate of micrometastasis detection (7%), even in high-risk patients (T3 and T4 tumors).
  • The downstaging effect of preoperative chemoradiation therapy may be significant in reducing even micrometastasis detection in low rectal cancer managed by this treatment strategy.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoadjuvant Therapy. Rectal Neoplasms / pathology. Rectal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Digestive System Surgical Procedures. Female. Fluorouracil / therapeutic use. Follow-Up Studies. Humans. Immunohistochemistry. Leucovorin / therapeutic use. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging. Radiotherapy, Adjuvant. Treatment Outcome. Vitamin B Complex / administration & dosage. Vitamin B Complex / therapeutic use

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  • (PMID = 15759124.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 12001-76-2 / Vitamin B Complex; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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77. Konski A, Li T, Sigurdson E, Cohen SJ, Small W Jr, Spies S, Yu JQ, Wahl A, Stryker S, Meropol NJ: Use of molecular imaging to predict clinical outcome in patients with rectal cancer after preoperative chemotherapy and radiation. Int J Radiat Oncol Biol Phys; 2009 May 1;74(1):55-9
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  • [Title] Use of molecular imaging to predict clinical outcome in patients with rectal cancer after preoperative chemotherapy and radiation.
  • PURPOSE: To correlate changes in 2-deoxy-2-[18F]fluoro-d-glucose (18-FDG) positron emission tomography (PET) (18-FDG-PET) uptake with response and disease-free survival with combined modality neoadjuvant therapy in patients with locally advanced rectal cancer.
  • METHODS AND MATERIALS: Charts were reviewed for consecutive patients with ultrasound-staged T3x to T4Nx or TxN1 rectal adenocarcinoma who underwent preoperative chemoradiation therapy at Fox Chase Cancer Center (FCCC) or Robert H.
  • Lurie Comprehensive Cancer Center of Northwestern University with 18-FDG-PET scanning before and after combined-modality neoadjuvant chemoradiation therapy .
  • CONCLUSIONS: A trend was observed for % SUV decrease and posttreatment SUV predicting pCR in patients with rectal cancer treated with preoperative chemoradiation therapy.
  • Further prospective study with a larger sample size is warranted to better characterize the role of 18-FDG-PET for response prediction in patients with rectal cancer.

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  • (PMID = 19004571.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA006927-449005; United States / NCI NIH HHS / CA / P30 CA006927-449005
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0W860991D6 / Deoxycytidine; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 50SG953SK6 / Mitomycin; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ NIHMS111700; NLM/ PMC2933375
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78. Huguier M, Barrier A, Zacharias T, Valinas R: [Positron emission tomography of gastrointestinal carcinomas]. Bull Acad Natl Med; 2006 Jan;190(1):75-84; discussion 84-7
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  • PET had a sensitivity of 67% and a specificity of 100% for metastases in 28 patients with cardio-esophageal carcinoma.
  • Among 70 patients with recurrent or metastatic colorectal carcinoma, eight had signs of local recurrence of rectal carcinoma treated by abdominoperineal resection; PET gave four true-positive, one false-negative, and three false-positive results.
  • PET was better than computed tomography (CT) for the diagnosis of peritoneal metastasis, but its sensitivity was only 58%.
  • PET modified the surgical strategy in two (7%) of 28 patients with cardio-esophageal carcinoma, one (5%) of 22 patients with pancreatic carcinoma, and 22 (33%) of 70 patients with colorectal carcinoma (appropriately in 11 cases, inappropriately in 11 cases).

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  • (PMID = 16878447.001).
  • [ISSN] 0001-4079
  • [Journal-full-title] Bulletin de l'Académie nationale de médecine
  • [ISO-abbreviation] Bull. Acad. Natl. Med.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Netherlands
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79. Beddy D, Hyland JM, Winter DC, Lim C, White A, Moriarty M, Armstrong J, Fennelly D, Gibbons D, Sheahan K: A simplified tumor regression grade correlates with survival in locally advanced rectal carcinoma treated with neoadjuvant chemoradiotherapy. Ann Surg Oncol; 2008 Dec;15(12):3471-7
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  • [Title] A simplified tumor regression grade correlates with survival in locally advanced rectal carcinoma treated with neoadjuvant chemoradiotherapy.
  • BACKGROUND: Locally advanced rectal cancer is frequently treated with neoadjuvant chemoradiotherapy to reduce local recurrence and possibly improve survival.
  • This study assessed tumor regression and its influence on survival in patients with rectal cancer treated with chemoradiotherapy followed by curative surgery.
  • METHODS: One hundred twenty-six patients with locally advanced rectal cancer (T3/T4 or N1/N2) were treated with chemoradiotherapy followed by total mesorectal excision.
  • CONCLUSION: Tumor regression grade measured on a 3-point system predicts outcome after chemoradiotherapy and surgery for locally advanced rectal cancer.
  • [MeSH-major] Adenocarcinoma / mortality. Rectal Neoplasms / mortality
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antimetabolites, Antineoplastic / therapeutic use. Chemotherapy, Adjuvant. Cohort Studies. Combined Modality Therapy. Female. Fluorouracil / therapeutic use. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Preoperative Care. Prognosis. Prospective Studies. Radiotherapy, Adjuvant. Remission Induction. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 18846402.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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80. Sun Myint A, Mukhopadhyay T, Ramani VS, Perkins K, Snee AJ, Jelley F, Wong H, Lee CD: Can increasing the dose of radiation by HDR brachytherapy boost following pre operative chemoradiotherapy for advanced rectal cancer improve surgical outcomes? Colorectal Dis; 2010 Aug;12 Suppl 2:30-6
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  • [Title] Can increasing the dose of radiation by HDR brachytherapy boost following pre operative chemoradiotherapy for advanced rectal cancer improve surgical outcomes?
  • AIM: Preoperative radiotherapy has been shown to improve local control in advanced rectal carcinoma compared with surgery alone.
  • METHOD: Since October 2004, we have used the new rectal HDR applicator for brachytherapy boost in 68 patients following CRT.
  • [MeSH-major] Brachytherapy / methods. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Dose-Response Relationship, Radiation. Female. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Recurrence, Local / prevention & control. Neoplasm Staging. Pilot Projects. Survival Analysis

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  • (PMID = 20618365.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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81. MERCURY Study Group: Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: results of the MERCURY study. Radiology; 2007 Apr;243(1):132-9
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  • [Title] Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: results of the MERCURY study.
  • PURPOSE: To prospectively evaluate the accuracy of magnetic resonance (MR) imaging in depicting the extramural depth of tumor invasion in patients who have rectal cancer, with histopathologic results as the reference standard.
  • MATERIALS AND METHODS: The Magnetic Resonance Imaging and Rectal Cancer European Equivalence (MERCURY) Study received ethics approval from all participating centers, and all patients gave informed consent.
  • Consecutive patients (n = 679) with adenocarcinoma of the rectum consented to participate.
  • [MeSH-major] Adenocarcinoma / pathology. Magnetic Resonance Imaging / methods. Rectal Neoplasms / pathology

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  • [CommentIn] Radiology. 2008 Feb;246(2):647; author reply 647-8 [18227560.001]
  • (PMID = 17329685.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Kontzoglou K, Moulakakis KG, Alexiou D, Safioleas MC, Nikiteas N, Giahnaki AE, Kyroudes A, Kostakis A, Karakitsos P: The role of liquid-based cytology in the investigation of colorectal lesions: a cytohistopathological correlation and evaluation of diagnostic accuracy. Langenbecks Arch Surg; 2007 Mar;392(2):189-95
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  • BACKGROUND AND AIMS: The role of cytologic techniques is not widely accepted even if it is well documented that the cytologic investigation of colorectal tract could complement the biopsy and increase the correct diagnosis of carcinomas.
  • Based on the final diagnosis, 89 out of 93 total malignant cases and 53 out of 53 total benign cases were correctly diagnosed with Thin-Prep(R) technique (four false negatives).
  • Accurate diagnosis with biopsy was performed in 87 out of 93 total malignant cases and 53 out of 53 total benign cases with biopsy (six false negatives).
  • CONCLUSIONS: Liquid-based cytology appears to be an easy, highly accurate, and reliable cytologic method for the diagnostic approach of colorectal diseases and could be applied as complementary to biopsy for the improvement of the diagnosis.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma / pathology. Condylomata Acuminata / pathology. Humans. Sensitivity and Specificity

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  • (PMID = 17294213.001).
  • [ISSN] 1435-2443
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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83. Avenel P, McKendrick A, Silapaswan S, Kolachalam R, Kestenberg W, Ferguson L, Jacobs MJ, Goriel Y, Mittal V: Gastrointestinal carcinoids: an increasing incidence of rectal distribution. Am Surg; 2010 Jul;76(7):759-63
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  • [Title] Gastrointestinal carcinoids: an increasing incidence of rectal distribution.
  • The rectum was the most common site for carcinoid tumors with an incidence of 30 per cent followed by jejunoileal at 29.3 per cent.
  • CT was not helpful in preoperative diagnosis of carcinoid tumor.
  • Fifteen patients died in follow-up with eight deaths related to carcinoid tumors, in the small bowel (6), rectum (1), and colon (1).
  • Most of the deaths occurred in patients with carcinoid syndrome, synchronous malignancy, and malignant carcinoid tumors.
  • Screening colonoscopy, in addition to decreasing colorectal adenocarcinoma mortality, is useful in diagnosing carcinoid tumors at an earlier stage and in decreasing mortality from malignant colorectal carcinoid tumors.
  • [MeSH-major] Carcinoid Tumor / surgery. Gastrointestinal Neoplasms / surgery. Rectal Neoplasms / surgery

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  • (PMID = 20698387.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Kim DW, Lim SB, Kim DY, Kim TH, Jung KH, Kim DH, Chang HJ, Sohn DK, Hong CW, Choi HS, Jeong SY, Park JG: Pre-operative chemo-radiotherapy improves the sphincter preservation rate in patients with rectal cancer located within 3 cm of the anal verge. Eur J Surg Oncol; 2006 Mar;32(2):162-7
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  • [Title] Pre-operative chemo-radiotherapy improves the sphincter preservation rate in patients with rectal cancer located within 3 cm of the anal verge.
  • AIMS: To evaluate whether pre-operative chemo-radiotherapy (CRT) improves the sphincter preservation rate for distal rectal cancers within 3 cm of the anal verge.
  • METHODS: Between January 2001 and December 2004, 49 patients underwent surgery with or without pre-operative CRT for primary rectal adenocarcinoma within 3 cm of the anal verge.
  • RESULTS: Of 49 patients with rectal tumours within 3 cm of the anal verge, 31 underwent pre-operative CRT followed by surgery (CRT group), and 18 underwent surgery alone (non-CRT group).
  • CONCLUSION: We could observe that sphincter preservation was improved in CRT group with statistical significance when compared to non-CRT group in our study patients with rectal cancer within 3 cm of the anal verge.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / therapy. Anal Canal / drug effects. Anal Canal / radiation effects. Neoadjuvant Therapy. Rectal Neoplasms / pathology. Rectal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antimetabolites, Antineoplastic / therapeutic use. Capecitabine. Chemotherapy, Adjuvant. Combined Modality Therapy. Confounding Factors (Epidemiology). Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Digestive System Surgical Procedures. Female. Fluorouracil / therapeutic use. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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  • (PMID = 16289718.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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85. Koh DM, Brown G, Temple L, Blake H, Raja A, Toomey P, Bett N, Farhat S, Norman AR, Daniels I, Husband JE: Distribution of mesorectal lymph nodes in rectal cancer: in vivo MR imaging compared with histopathological examination. Initial observations. Eur Radiol; 2005 Aug;15(8):1650-7
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  • [Title] Distribution of mesorectal lymph nodes in rectal cancer: in vivo MR imaging compared with histopathological examination. Initial observations.
  • The aim of this work was to determine the distribution of mesorectal lymph nodes using T2-weighted magnetic resonance (MR) imaging compared with histopathological findings in patients with rectal carcinoma.
  • Sixteen patients with rectal carcinoma undergoing primary surgery without pre-operative neoadjuvant treatment were evaluated using 3-mm axial T2-weighted MR imaging.
  • The position of each visible mesorectal node on imaging was localised by measuring its minimum distance from the mesorectal fascia (d(m)), its minimum distance from the rectal wall (d(r)) and its distance from the distal tumour margin (d(v)).
  • [MeSH-major] Adenocarcinoma / pathology. Lymph Nodes / pathology. Magnetic Resonance Imaging. Rectal Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Prospective Studies. Rectum / pathology

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  • (PMID = 15868124.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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86. Dougherty KR, Khettry U, Stoffel JT, Schoetz DJ: Rectal adenocarcinoma with metachronous metastases to the urethra. Am Surg; 2009 Mar;75(3):265-6
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  • [Title] Rectal adenocarcinoma with metachronous metastases to the urethra.
  • [MeSH-major] Adenocarcinoma / secondary. Neoplasms, Second Primary / secondary. Rectal Neoplasms / pathology. Urethral Neoplasms / secondary

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  • (PMID = 19350868.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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87. Chew MH, Yeo SA, Ng ZP, Lim KH, Koh PK, Ng KH, Eu KW: Critical analysis of mucin and signet ring cell as prognostic factors in an Asian population of 2,764 sporadic colorectal cancers. Int J Colorectal Dis; 2010 Oct;25(10):1221-9
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  • METHODS: Consecutive patients (2,764) with sporadic colorectal cancer from 1999 to 2005 were evaluated.
  • SRC and MA are more likely to have locally advanced lesions (T3/T4; SRC 100%, MA 90%, OA 83%, p = 0.002) and lymph node metastases (SRC 89%, MA 61%, OA 52%, p < 0.0001) and present with an advanced stage at diagnosis (stage III/IV SRC 94%, MA 67%, OA 56%, p < 0.0001).
  • SRC has poorer 5-year cancer-specific survival (CSS; 11.1%, 95% confidence interval (CI) 0-22.9%) compared with MA (46.8%, 95% CI 38.6-55.0%) and OA (58.7%, 95% CI 56.5-60.9%, p < 0.001).
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Signet Ring Cell / pathology. Colorectal Neoplasms / diagnosis. Mucins / analysis

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  • (PMID = 20686777.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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88. Karaman K, Bostanci EB, Ercan M, Kurt M, Teke Z, Reyhan E, Akoglu M: Topical Ankaferd application to presacral bleeding due to total mesorectal excision in rectal carcinoma. J Invest Surg; 2010 Jun;23(3):175
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  • [Title] Topical Ankaferd application to presacral bleeding due to total mesorectal excision in rectal carcinoma.
  • [MeSH-major] Blood Loss, Surgical / prevention & control. Plant Extracts / therapeutic use. Rectal Neoplasms / surgery

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  • [CommentOn] J Invest Surg. 2009 May-Jun;22(3):201-6 [19466658.001]
  • (PMID = 20590390.001).
  • [ISSN] 1521-0553
  • [Journal-full-title] Journal of investigative surgery : the official journal of the Academy of Surgical Research
  • [ISO-abbreviation] J Invest Surg
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Plant Extracts; 0 / ankaferd blood stopper
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89. Gupta S, Sodhi S, Kaur J, Yamini J: Improvement in electrolyte imbalance in critically ill patient after magnesium supplementation - A case report. Indian J Clin Biochem; 2009 Apr;24(2):208-10
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  • Hypomagnesaemia is common finding in current medical practice mainly in critically ill, post-operative patients and patients admitted to ICU in tertiary cancer cases.
  • We report a case of 60 year old patient, suffering from rectal carcinoma for a period of one year with confirmed hypokalemia, hypocalcaemia and hyponatremia.

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  • (PMID = 23105836.001).
  • [ISSN] 0970-1915
  • [Journal-full-title] Indian journal of clinical biochemistry : IJCB
  • [ISO-abbreviation] Indian J Clin Biochem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3453216
  • [Keywords] NOTNLM ; Hypocalcaemia / Hypokalemia / Hypomagnesaemia / Hyponatremia
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90. Jiang SM, Wang RB, Yu JM, Zhu KL, Mu DB, Xu ZF: [Correlation of VEGF and Ki67 expression with sensitivity to neoadjuvant chemoradiation in rectal adenocarcinoma]. Zhonghua Zhong Liu Za Zhi; 2008 Aug;30(8):602-5
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  • [Title] [Correlation of VEGF and Ki67 expression with sensitivity to neoadjuvant chemoradiation in rectal adenocarcinoma].
  • OBJECTIVE: To investigate the correlation of expression of vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (Ki67) with sensitivity to neoadjuvant chemoradiation in rectal adenocarcinoma.
  • METHODS: Samples of pretreatment biopsies and the resected specimens after neoadjuvant therapy in 32 patients with rectal adenocarcinoma were collected, and the expression of Ki67 and VEGF were detected by immunohistochemistry using specific antibodies.
  • CONCLUSION: The preliminary results of this study demonstrate that the expression of VEGF and Ki67 in pretreatment biopsy of rectal adenocarcinoma may be used as a biomarker to predict tumor response to neoadjuvant chemoradiation.
  • [MeSH-major] Adenocarcinoma / therapy. Ki-67 Antigen / metabolism. Neoadjuvant Therapy. Rectal Neoplasms / therapy. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / metabolism. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Radiotherapy, Conformal. Young Adult

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  • (PMID = 19102938.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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91. Johnson JC, Schmidt CR, Shrubsole MJ, Billheimer DD, Joshi PR, Morrow JD, Heslin MJ, Washington MK, Ness RM, Zheng W, Schwartz DA, Coffey RJ, Beauchamp RD, Merchant NB: Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol; 2006 Nov;4(11):1358-65
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  • Thirteen rectal carcinoma patients were treated with celecoxib and urinary PGE-M was measured before and after treatment.
  • PGE-M levels decreased significantly after celecoxib treatment in patients with rectal cancer (median, 21.7 [IQR, 16.2-29.9] vs 9.14 [IQR, 7.14-13.2], P = .009).
  • [MeSH-major] Colorectal Neoplasms / diagnosis. Prostaglandins / urine
  • [MeSH-minor] Adenoma / diagnosis. Aged. Biomarkers, Tumor. Colonic Polyps / diagnosis. Crohn Disease / diagnosis. Crohn Disease / urine. Cyclooxygenase 2 / metabolism. Female. Humans. Immunohistochemistry. Logistic Models. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 16996805.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA46413; United States / NIDDK NIH HHS / DK / DK48831; United States / NIDDK NIH HHS / DK / T32 DK007673; United States / NIDDK NIH HHS / DK / DK52334; United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / R01 CA046413; United States / NCI NIH HHS / CA / T32 CA106183; United States / NIGMS NIH HHS / GM / GM15431; United States / NIDDK NIH HHS / DK / DK07673; United States / NIDDK NIH HHS / DK / R01 DK048831; United States / NCI NIH HHS / CA / P01 CA077839; United States / NCI NIH HHS / CA / CA106183; United States / NIGMS NIH HHS / GM / P50 GM015431; United States / NCRR NIH HHS / RR / RR00095; United States / NCI NIH HHS / CA / P30 CA068485; United States / NCRR NIH HHS / RR / M01 RR000095; United States / NCI NIH HHS / CA / CA95103; United States / NIDDK NIH HHS / DK / R01 DK052334; United States / NCI NIH HHS / CA / CA68485; United States / NCI NIH HHS / CA / CA77839; United States / NCI NIH HHS / CA / CA69457
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Prostaglandins; 73303-30-7 / 7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid; EC 1.14.99.1 / Cyclooxygenase 2
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92. Gao F, Li C, Li W, Chen L, Tang Z, Tang W: p53 Gene mutations in sporadic colorectal carcinoma in Guangxi region. Cancer Invest; 2006 Nov;24(7):689-95
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  • [Title] p53 Gene mutations in sporadic colorectal carcinoma in Guangxi region.
  • To explore the spectrum of p53 gene mutations of sporadic colorectal carcinoma in Guangxi, a Zhuang autonomous region in southern China, we examined exons 2 approximately 11 and exon-intron junctions of p53 gene from 48 patients with sporadic colorectal carcinoma by using single strand conformation polymorphism (SSCP) and DNA direct sequencing.
  • The frequency (47.83 percent) of p53 gene mutations in rectal carcinoma was higher than that (16 percent) in colonic carcinoma (P < 0.025).
  • [MeSH-major] Colonic Neoplasms / genetics. Mutation / genetics. Rectal Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. China. DNA, Neoplasm / genetics. Exons / genetics. Female. Humans. Male. Middle Aged. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational

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  • (PMID = 17118779.001).
  • [ISSN] 0735-7907
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Tumor Suppressor Protein p53
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93. Haidinger G, Waldhoer T, Hackl M, Vutuc C: Survival of patients with colorectal cancer in Austria by sex, age, and stage. Wien Med Wochenschr; 2006 Oct;156(19-20):549-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival of patients with colorectal cancer in Austria by sex, age, and stage.
  • This paper for the first time presents Austrian data on survival of patients, diagnosed from 1998 through 2002, with colon cancer and with rectal cancer.
  • In carcinoma of the colon 5-year relative survival was 66 % in males and 64 % in females.
  • In carcinoma of the rectum 5-year relative survival was 64 % in males and 67 % in females.
  • Compared to the earlier results from the Tyrol (based on patients diagnosed from 1990 through 1994) the 5-year survival of patients with colon cancer increased from 55 % to 66 % in males and from 58 % to 64 % in females.
  • In patients with rectal cancer 5-year survival increased from 44 % to 64 % in males and from 46 % to 67 % in females.
  • [MeSH-minor] Age Factors. Aged. Austria. Early Diagnosis. Female. Humans. Male. Middle Aged. Neoplasm Staging. Sex Factors. Survival Rate

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  • [Cites] Eur J Cancer. 2005 Oct;41(15):2321-30 [16125930.001]
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  • (PMID = 17103293.001).
  • [ISSN] 0043-5341
  • [Journal-full-title] Wiener medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Wien Med Wochenschr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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94. Yamamoto S, Fukunaga M, Miyajima N, Okuda J, Konishi F, Watanabe M, Japan Society of Laparoscopic Colorectal Surgery: Impact of conversion on surgical outcomes after laparoscopic operation for rectal carcinoma: a retrospective study of 1,073 patients. J Am Coll Surg; 2009 Mar;208(3):383-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of conversion on surgical outcomes after laparoscopic operation for rectal carcinoma: a retrospective study of 1,073 patients.
  • BACKGROUND: In laparoscopic operations for rectal carcinoma, only a few multicenter studies of a large number of patients have examined the impact of conversion on outcomes and determined risk factors for conversion.
  • This study was designed to evaluate short-term outcomes and risk factors for conversion to open operation in laparoscopic operations for rectal carcinoma.
  • STUDY DESIGN: A total of 1,073 patients with carcinoma of the rectum and anus who underwent laparoscopic operations were reviewed retrospectively.
  • Body mass index and the particular laparoscopic procedure are risk factors for conversion, indicating that appropriate patient selection is essential in laparoscopic operations for rectal carcinoma.
  • [MeSH-major] Digestive System Surgical Procedures. Laparoscopy. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / surgery. Body Mass Index. Female. Humans. Intraoperative Complications / classification. Intraoperative Complications / epidemiology. Intraoperative Complications / etiology. Length of Stay. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Postoperative Complications / classification. Postoperative Complications / epidemiology. Postoperative Complications / etiology. Postoperative Hemorrhage / epidemiology. Retrospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 19318000.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Investigator] Watanabe M; Kokuba Y; Konishi F; Kawamura Y; Miyajima N; Fukunaga M; Kudo S; Tanaka J; Tanigawa N; Okuda J; Nagai H; Otsuka K; Fukunaga Y; Okajima M; Bandou H; Kitano S; Inomata M; Kubo Y; Ichihara T; Hasegawa H; Yamamoto S; Ikoma S; Nishiyama Y; Sugihara K; Yamaguchi S; Sekimoto M; Masaki M; Idani H; Sumiyama Y; Saida Y; Munemoto Y; Maeda K; Hanai K; Kuroyanagi H; Ueda K
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95. Panis Y: [Laparoscopy and colorectal cancer]. Bull Acad Natl Med; 2007 Oct;191(7):1375-8; discussion 1379
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  • [Title] [Laparoscopy and colorectal cancer].
  • [Transliterated title] Laparoscopie et cancer colorectal.
  • Laparoscopy is associated with better postoperative outcome than laparotomy in the treatment of colon cancer, and similar oncologic results.
  • Thus, laparoscopy is now a validated approach to colon cancer management.
  • In contrast, more studies are needed before endorsing the use of laparoscopy to treat rectal carcinoma.
  • [MeSH-minor] Colectomy / methods. Female. Humans. Male. Randomized Controlled Trials as Topic / statistics & numerical data. Rectal Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18447059.001).
  • [ISSN] 0001-4079
  • [Journal-full-title] Bulletin de l'Académie nationale de médecine
  • [ISO-abbreviation] Bull. Acad. Natl. Med.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 10
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96. Taher AN, El-Baradie MM, Nasr AM, Khorshid O, Morsi A, Hamza MR, Mokhtar N, Ezzat S: Locally advanced rectal carcinoma: preoperative radiotherapy versus postoperative chemoradiation, 10-year follow-up results of a randomized clinical study. J Egypt Natl Canc Inst; 2006 Sep;18(3):233-43
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  • [Title] Locally advanced rectal carcinoma: preoperative radiotherapy versus postoperative chemoradiation, 10-year follow-up results of a randomized clinical study.
  • PURPOSE: A prospective study was designed to randomize locally advanced rectal carcinoma patients between either preoperative radiotherapy (+/- postoperative chemotherapy) or postoperative adjuvant chemoradiation.
  • PATIENTS AND METHODS: This is a prospective randomized clinical study including patients with locally advanced low rectal cancer treated at the National Cancer Institute (NCI), Cairo University, during the period from December 1994 to January 1999.
  • Fifty patients with previously untreated rectal cancer were randomized into two groups, Group I: Subjected to surgery followed by radiation therapy (50Gy/5 weeks, 2Gy/fraction, 5 days/week) plus chemotherapy and Group II, subjected to preoperative radiotherapy (46Gy/4.5 weeks, 2Gy/ fraction, 5 days/week) followed by surgery +/- postoperative chemotherapy.
  • [MeSH-major] Carcinoma / mortality. Carcinoma / radiotherapy. Postoperative Care. Preoperative Care. Rectal Neoplasms / mortality. Rectal Neoplasms / radiotherapy

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  • (PMID = 17671533.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Egypt
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97. Sciubba DM, Nelson C, Gok B, McGirt MJ, McLoughlin GS, Noggle JC, Wolinsky JP, Witham TF, Bydon A, Gokaslan ZL: Evaluation of factors associated with postoperative infection following sacral tumor resection. J Neurosurg Spine; 2008 Dec;9(6):593-9
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  • However, extensive soft-tissue resection in close proximity to the rectum may predispose patients to wound complications and infection.
  • Histopathological findings included the following: chordoma in 19 (41%), ependymoma in 5 (11%), rectal adenocarcinoma in 5 (11%), giant cell tumor in 4 (9%), and other in 13 (28%).
  • CONCLUSIONS: Patients undergoing sacral tumor surgery may be at greater risk for developing wound complications due to the extensive soft-tissue resections often required, especially with the increased potential for contamination from the neighboring rectum.

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  • (PMID = 19035755.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Lemmens V, van Steenbergen L, Janssen-Heijnen M, Martijn H, Rutten H, Coebergh JW: Trends in colorectal cancer in the south of the Netherlands 1975-2007: rectal cancer survival levels with colon cancer survival. Acta Oncol; 2010 Aug;49(6):784-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trends in colorectal cancer in the south of the Netherlands 1975-2007: rectal cancer survival levels with colon cancer survival.
  • OBJECTIVE: In the Netherlands over 11 200 patients are yearly diagnosed with colorectal cancer (CRC), of who about 4 700 are expected to die of the disease ultimately.
  • PATIENTS: The 26 826 cases of primary CRC (C18.0-C20.9) diagnosed between 1975 and 2007 in the Dutch population-based Eindhoven Cancer Registry area were included.
  • RESULTS: The age-standardised incidence of colon carcinoma kept increasing, most markedly in males (up to 39 patients per 100 000 inhabitants) and for tumours of the colon ascendens (subsite-specific incidence doubled).
  • The incidence of rectal carcinoma remained stable.
  • The proportion of patients diagnosed with distant metastases increased up to 25% for colon carcinoma (p<0.0001).
  • Recently, the use of adjuvant chemotherapy seemed to level off among patients with stage III colon carcinoma, but the use of neo-adjuvant chemoradiation clearly increased among patients with stage II/III rectal cancer (p<0.0001).
  • Five-year relative survival of colon cancer improved from 51% in 1975-1984 to 58% in 2000-2004, for rectal cancer it improved from 44 to 59%.
  • Two-year relative survival of colon cancer in 2005-2006 was 69%, and 77% for rectal cancer.
  • CONCLUSIONS: The changes in management of rectal cancer led to a superior increase in survival of these patients compared to patients with colon cancer, even surpassing the latter.
  • [MeSH-major] Colonic Neoplasms / epidemiology. Rectal Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Male. Middle Aged. Mortality / trends. Neoplasm Staging. Netherlands / epidemiology. Prevalence. Registries. Survival Analysis

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  • (PMID = 20429731.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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99. Friedland S, Benaron D, Maxim P, Parachikov I, Soetikno R: Absence of ischemia in telangiectasias of chronic radiation proctopathy. Endoscopy; 2006 May;38(5):488-92
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  • We therefore hypothesized that the ischemia theory is incorrect and that rectal capillary oxygen saturation is normal in patients with telangiectasias of chronic radiation proctopathy.
  • We prospectively studied 20 patients who had typical findings of multiple rectal telangiectasias, 1 - 20 years after undergoing external-beam irradiation for prostate or rectal carcinoma.
  • We measured and compared the mucosal capillary oxygen saturations in the affected areas of the distal rectum and in endoscopically normal areas in the rectosigmoid colon.
  • The mean mucosal hemoglobin oxygen saturation was actually slightly higher in the affected areas of the rectum than in the uninvolved rectosigmoid colon (73 % vs. 69 %, P < 0.01).
  • This finding may explain why endoscopic treatment of this disorder, in which large areas of the mucosa are coagulated with argon plasma or other treatment modalities that cause widespread ulceration, does not typically result in complications from poor wound healing.
  • [MeSH-major] Colonoscopes. Colonoscopy / methods. Gastrointestinal Hemorrhage / diagnosis. Gastrointestinal Hemorrhage / etiology. Ischemia / diagnosis. Ischemia / etiology. Radiotherapy / adverse effects. Rectal Diseases / diagnosis. Rectal Diseases / etiology. Telangiectasis / diagnosis. Telangiectasis / etiology


100. Daniel WJ: Anorectal pain, bleeding and lumps. Aust Fam Physician; 2010 Jun;39(6):376-81
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  • BACKGROUND: The patient presenting with anal pain, anal lump or rectal bleeding is a common occurrence in the general practice setting and the combination of symptoms usually gives an indication of the most likely diagnosis.
  • However, careful examination including digital rectal examination is always required.
  • OBJECTIVE: This article discusses three common anorectal conditions: perianal haematoma, haemorrhoids and anal fissure, and briefly discusses the less common, but not to be missed conditions: anal carcinoma and low rectal carcinoma.
  • Anal cancer has similar presentation to haemorrhoids and carcinoma of distal rectum can initially present with a haemorrhoid, so the possibility of anorectal cancer should be considered in any patient presenting with haemorrhoids, tenesmus and change in bowel habit.
  • [MeSH-major] Pain / diagnosis. Rectal Diseases / physiopathology
  • [MeSH-minor] Diagnosis, Differential. Hemorrhage / etiology. Humans

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  • (PMID = 20628675.001).
  • [ISSN] 0300-8495
  • [Journal-full-title] Australian family physician
  • [ISO-abbreviation] Aust Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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