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46. Vinikoor LC, Satia JA, Schroeder JC, Millikan RC, Martin CF, Ibrahim JG, Sandler RS: Associations between trans fatty acid consumption and colon cancer among Whites and African Americans in the North Carolina colon cancer study I. Nutr Cancer; 2009;61(4):427-36
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  • [Title] Associations between trans fatty acid consumption and colon cancer among Whites and African Americans in the North Carolina colon cancer study I.
  • Disparities in incidence and mortality rates of colon cancer exist between Whites and African Americans.
  • Prior studies examined the association between trans fatty acid consumption and colorectal cancer, but none assessed this possible relationship within a large study population of African Americans and Whites.
  • Energy-adjusted trans fatty acid consumption was not associated with colon cancer.
  • In conclusion, trans fatty acid consumption is not associated with colon cancer and does not contribute to disparities in colon cancer rates.

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  • (PMID = 19838914.001).
  • [ISSN] 1532-7914
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01CA66635; United States / NIDDK NIH HHS / DK / P30 DK034987; United States / NIDDK NIH HHS / DK / DK034987-25; United States / NCI NIH HHS / CA / R01 CA066635; United States / NIDDK NIH HHS / DK / T32 DK007634-20; United States / NIDDK NIH HHS / DK / DK56350; United States / NIDDK NIH HHS / DK / DK007634-20; United States / NIDDK NIH HHS / DK / P30 DK056350; United States / NCI NIH HHS / CA / R01 CA066635-09; United States / NIDDK NIH HHS / DK / P30DK34987; United States / NIDDK NIH HHS / DK / T32 DK007634; United States / NIDDK NIH HHS / DK / T32DK07634; United States / NIDDK NIH HHS / DK / P30 DK034987-25
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Fats; 0 / Trans Fatty Acids
  • [Other-IDs] NLM/ NIHMS190542; NLM/ PMC2853475
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47. Sakellaridis T, Mathioulakis S, Antiochos C: Synchronous early primary adenocarcinoma of both rectum and gallbladder. Report of a case. Int Semin Surg Oncol; 2005 Sep 14;2:19
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  • [Title] Synchronous early primary adenocarcinoma of both rectum and gallbladder. Report of a case.
  • BACKGROUND: Synchronous early primary cancers are rare and in addition synchronous adenocarcinoma of both rectum and gallbladder is extremely rare.
  • CASE REPORT: We report an unusual case of synchronous early primary adenocarcinoma of rectum and gallbladder.
  • An endoscopy revealed adenocarcinoma of the lower rectum.
  • The histopathological diagnosis was well to middle differentiate adenocarcinoma of the gallbladder (T2, N0, M0; stage II) and middle differentiate adenocarcinoma of the rectum (T2, N0, M0; stage II).
  • CONCLUSION: For the cases of extracolonic primary cancer associated with colorectal primary carcinoma, Warren and Gates' diagnostic criteria are used.
  • All patients with colorectal carcinoma, should undergo a throughout preoperative examination to exclude the possibility of synchronous early primary cancers.

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  • (PMID = 16162293.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1236954
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48. Ozmen V, Asoglu O, Karanlik H, Cabioglu N, Kecer M, Bakkaloglu H: Primary ovarian cancer presenting with axillary lymph node metastases: a report of two cases. Acta Chir Belg; 2007 Jan-Feb;107(1):75-7
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  • [Title] Primary ovarian cancer presenting with axillary lymph node metastases: a report of two cases.
  • BACKGROUND: Axillary lymph node metastasis of primary ovarian cancer is rare.
  • She had a history of stage IIIA epithelial ovarian cancer which was diagnosed and treated four years previously.
  • A right lateral wall involvement of the rectum was detected in abdominal tomography.
  • A right axillary lymph node dissection and low anterior resection of the rectum were performed.
  • Histopathologic examination showed ovarian epithelial serous papillary adenocarcinoma metastases to axillary lymph node and the rectum.
  • She was treated surgically and by systemic chemotherapy with a diagnosis of stage IIIA epithelial ovarian cancer two years previously.
  • A trucut biopsy was taken from the enlarged axillary lymph node, and histopathological examination revealed metastases of primary ovarian cancer.
  • Complete axillary lymph node dissection was performed and metastases of ovarian papillary adenocarcinoma were found in 11 of the 30 lymph nodes.
  • CONCLUSION: Supradiaphragmatic lymph node involvement of primary ovarian cancer is very rare.
  • We report here two cases presenting with axillary metastases of ovarian cancer.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Lymphatic Metastasis. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Axilla. Female. Humans. Lymph Node Excision. Rectal Neoplasms / pathology. Rectal Neoplasms / secondary

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  • (PMID = 17405606.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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49. Seo T, Tatsuguchi A, Shinji S, Yonezawa M, Mitsui K, Tanaka S, Fujimori S, Gudis K, Fukuda Y, Sakamoto C: Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients. Virchows Arch; 2009 Jun;454(6):667-76
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  • [Title] Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients.
  • The aim of this study is to investigate the expression of three prostaglandin E synthase (PGES) isomers in colorectal cancer (CRC) tissue and to evaluate their relationship to clinicopathological factors and patient prognosis.
  • The localization of each PGES and COX-2 protein was examined by immunohistochemistry in 155 surgical resections and correlated to clinicopathological factors and patient prognosis. mPGES-1 mRNA and protein levels were significantly higher in CRC than in paired normal tissues. mPGES-1 immunoreactivity localized in cancer cells in 43% of cases. mPGES-2 immunoreactivity was significantly more pronounced in cancer cells than in adjacent normal epithelium in 36% of cases. cPGES immunoreactivity was homogeneous in cancer cells and thus determined constitutive. mPGES-1 and mPGES-2 correlated with significantly worse prognosis in stage I-III patients.
  • [MeSH-major] Adenocarcinoma / enzymology. Colorectal Neoplasms / enzymology. Intramolecular Oxidoreductases / metabolism. Microsomes / enzymology

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  • (PMID = 19412621.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Isoenzymes; 0 / RNA, Messenger; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.3 / PTGES protein, human; EC 5.3.99.3 / PTGES2 protein, human; EC 5.3.99.3 / Prostaglandin-E Synthases
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50. Ripley RT, Davis JL, Kemp CD, Steinberg SM, Toomey MA, Avital I: Prospective randomized trial evaluating mandatory second look surgery with HIPEC and CRS vs. standard of care in patients at high risk of developing colorectal peritoneal metastases. Trials; 2010 May 25;11:62
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  • Peritoneal carcinomatosis from colorectal cancer treated with chemotherapy alone results in median survival of 5 to 13 months, whereas CRS with HIPEC for early peritoneal carcinomatosis from colorectal cancer resulted in median survival of 48-63 months and 5 year survival of 51%.Completeness of cytoreduction and limited disease are associated with longer survival, yet early peritoneal carcinomatosis is undetectable by conventional imaging.
  • We hypothesize that performing a mandatory second look laparotomy with CRS and HIPEC for patients who are at high risk for developing peritoneal carcinomatosis from colorectal cancer will lead to improved survival as compared to patients who receive standard of care with routine surveillance.
  • METHODS/DESIGN: This study is a prospective randomized trial designed to answer the question whether mandatory second look surgery with CRS and HIPEC will prolong overall survival compared to the standard of care in patients who are at high risk for developing peritoneal carcinomatosis from colorectal cancer (CRC).
  • [MeSH-major] Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Cancer, Regional Perfusion. Colorectal Neoplasms / therapy. Hyperthermia, Induced. Laparotomy. Peritoneal Neoplasms / therapy. Second-Look Surgery

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  • (PMID = 20500867.001).
  • [ISSN] 1745-6215
  • [Journal-full-title] Trials
  • [ISO-abbreviation] Trials
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT01095523
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2889988
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51. Chan AC, Poon JT, Fan JK, Lo SH, Law WL: Impact of conversion on the long-term outcome in laparoscopic resection of colorectal cancer. Surg Endosc; 2008 Dec;22(12):2625-30
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  • [Title] Impact of conversion on the long-term outcome in laparoscopic resection of colorectal cancer.
  • BACKGROUND: Long-term outcome of patients with conversion following laparoscopic resection of colorectal cancer has seldom been reported.
  • Consequently, patients in the conversion group were more likely to develop local recurrence (9.8% versus 2.8%, P < 0.001) with a significantly reduced cumulative cancer-free survival.
  • [MeSH-major] Adenocarcinoma / surgery. Colectomy / methods. Colorectal Neoplasms / surgery. Laparoscopy / statistics & numerical data. Laparotomy / statistics & numerical data
  • [MeSH-minor] Aged. Blood Loss, Surgical / statistics & numerical data. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Length of Stay / statistics & numerical data. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Prospective Studies. Survival Analysis. Treatment Outcome. Tumor Burden

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  • (PMID = 18297346.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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52. Vijayasekar C, Noormohamed S, Cheetham MJ: Late recurrence of large peri-stomal metastasis following abdomino-perineal resection of rectal cancer. World J Surg Oncol; 2008;6:96
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  • [Title] Late recurrence of large peri-stomal metastasis following abdomino-perineal resection of rectal cancer.
  • BACKGROUND: Cutaneous metastasis from colorectal cancer after excision of the primary is a rare occurrence and presents as cutaneous or subcutaneous nodules or as a rash commonly on the anterior abdominal wall.
  • CASE PRESENTATION: This is a case description of the management of a large fungating peristomal cutaneous metastasis occurring 14 years after abdomino-perineal excision of the primary cancer.
  • The gross appearance initially suggested possibility of a true metachronous cancer with peristomal spread.
  • Literature review of presentation, management and prognosis of cutaneous metastasis from colorectal cancer is described CONCLUSION: Cutaneous metastasis following colorectal cancer resection is a well-recognised entity though rare.
  • [MeSH-major] Adenocarcinoma / surgery. Colostomy. Neoplasm Recurrence, Local / surgery. Rectal Neoplasms / surgery. Skin Neoplasms / surgery

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  • (PMID = 18771600.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2542374
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53. Lang K, Lines LM, Lee DW, Korn JR, Earle CC, Menzin J: Trends in healthcare utilization among older Americans with colorectal cancer: a retrospective database analysis. BMC Health Serv Res; 2009;9:227
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  • [Title] Trends in healthcare utilization among older Americans with colorectal cancer: a retrospective database analysis.
  • BACKGROUND: Analyses of utilization trends (cost drivers) allow us to understand changes in colorectal cancer (CRC) costs over time, better predict future costs, identify changes in the use of specific types of care (eg, hospice), and provide inputs for cost-effectiveness models.
  • METHODS: Cohorts included patients aged 66+ newly diagnosed with adenocarcinoma of the colon (n = 52,371) or rectum (n = 18,619) between 1992 and 2002 and matched patients from the general Medicare population, followed until death or December 31, 2005.
  • Demographic and clinical characteristics were evaluated by cancer subsite.

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  • (PMID = 20003294.001).
  • [ISSN] 1472-6963
  • [Journal-full-title] BMC health services research
  • [ISO-abbreviation] BMC Health Serv Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2797788
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5
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4. Papatheodorou A, Ellinas P, Tandeles S, Takis F, Poulias H, Nikolaou I, Batakis N: Transrectal ultrasonography and ultrasound-guided biopsies of the prostate gland: how, when, and where. Curr Probl Diagn Radiol; 2005 Mar-Apr;34(2):76-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Contrast Media. Humans. Male. Microbubbles. Middle Aged. Prostatic Hyperplasia / pathology. Rectum

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  • (PMID = 15753881.001).
  • [ISSN] 0363-0188
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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55. Jabbari S, Hsu IC, Kawakami J, Weinberg VK, Speight JL, Gottschalk AR, Roach M 3rd, Shinohara K: High-dose-rate brachytherapy for localized prostate adenocarcinoma post abdominoperineal resection of the rectum and pelvic irradiation: Technique and experience. Brachytherapy; 2009 Oct-Dec;8(4):339-44
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  • [Title] High-dose-rate brachytherapy for localized prostate adenocarcinoma post abdominoperineal resection of the rectum and pelvic irradiation: Technique and experience.
  • PURPOSE: Treatment options are limited for patients with localized prostate cancer and a prior history of abdominoperineal resection (APR) and pelvic irradiation.
  • We have previously reported on the successful utility of high-dose-rate (HDR) brachytherapy salvage for prostate cancer failing definitive external beam radiation therapy (EBRT).
  • PATIENTS AND METHODS: Six men with newly diagnosed localized prostate cancer had a prior history of APR and pelvic EBRT.
  • CONCLUSION: Transperineal ultrasound-guided HDR brachytherapy using the above technique should be considered as definitive therapy for patients with localized prostate cancer and a prior history of APR and pelvic EBRT.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Brachytherapy / methods. Prostatic Neoplasms / radiotherapy

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  • (PMID = 19428310.001).
  • [ISSN] 1538-4721
  • [Journal-full-title] Brachytherapy
  • [ISO-abbreviation] Brachytherapy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Grossmann I, de Bock GH, Meershoek-Klein Kranenbarg WM, van de Velde CJ, Wiggers T: Carcinoembryonic antigen (CEA) measurement during follow-up for rectal carcinoma is useful even if normal levels exist before surgery. A retrospective study of CEA values in the TME trial. Eur J Surg Oncol; 2007 Mar;33(2):183-7
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  • [Title] Carcinoembryonic antigen (CEA) measurement during follow-up for rectal carcinoma is useful even if normal levels exist before surgery. A retrospective study of CEA values in the TME trial.
  • BACKGROUND: Carcinoembryonic antigen (CEA) as a marker in the follow-up after curative resection of colorectal carcinoma (CRC) is often omitted from follow-up despite guideline recommendations.
  • METHOD: Data were derived from a study initiated to evaluate treatment regimes for rectal carcinoma (Dutch TME trial, n=1861) from which 954 were eligible for analysis.
  • CONCLUSION: A normal pre-operative CEA is common in patients with rectal carcinoma.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoembryonic Antigen / blood. Colectomy / methods. Preoperative Care. Rectal Neoplasms / blood
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Clinical Trials as Topic. Disease Progression. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local / blood. Neoplasm Recurrence, Local / epidemiology. Netherlands / epidemiology. Prognosis. Retrospective Studies

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  • (PMID = 17174516.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen
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57. Tsunoda A, Kamiyama G, Narita K, Watanabe M, Nakao K, Kusano M: Prospective randomized trial for determination of optimum size of side limb in low anterior resection with side-to-end anastomosis for rectal carcinoma. Dis Colon Rectum; 2009 Sep;52(9):1572-7
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  • [Title] Prospective randomized trial for determination of optimum size of side limb in low anterior resection with side-to-end anastomosis for rectal carcinoma.
  • METHODS: Forty-four patients with a mid or low rectal cancer undergoing low anterior resection were randomly assigned to each group.
  • [MeSH-major] Carcinoma / surgery. Proctocolectomy, Restorative / methods. Rectal Neoplasms / surgery

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  • (PMID = 19690484.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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58. Onodera M, Nishigami T, Torii I, Sato A, Tao LH, Kataoka TR, Yoshikawa R, Tsujimura T: Comparison between colorectal low- and high-grade mucinous adenocarcinoma with MUC1 and MUC5AC. World J Gastrointest Oncol; 2009 Oct 15;1(1):69-73
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  • [Title] Comparison between colorectal low- and high-grade mucinous adenocarcinoma with MUC1 and MUC5AC.
  • AIM: To explore useful prognostic factors for mucinous adenocarcinoma (MAC) in the colon and rectum.
  • METHODS: MAC was divided into low- and high-grade types based on the degree of structural differentiation; low-grade MAC arisen from well to moderately differentiated adenocarcinoma and papillary carcinoma, and high-grade MAC from poorly differentiated adenocarcinoma and signet ring cell carcinoma.

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  • (PMID = 21160777.001).
  • [ISSN] 1948-5204
  • [Journal-full-title] World journal of gastrointestinal oncology
  • [ISO-abbreviation] World J Gastrointest Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999097
  • [Keywords] NOTNLM ; Colon / MUC1 / MUC5AC / Mucinous adenocarcinoma / Rectum
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59. Cimitan A, Burza A, Basile U, Saputo S, Mingazzini P, Stipa F: [Local excision of giant rectal polypoid neoplasms]. Chir Ital; 2008 May-Jun;60(3):345-53
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  • [Title] [Local excision of giant rectal polypoid neoplasms].
  • [Transliterated title] Escissione locale delle neoplasie polipoidi giganti del retto.
  • Local excision is the best therapeutic option for giant adenomas of the rectum.
  • Parks technique for lower rectal lesions and the T.E.M. technique for lesions localised in the middle and upper rectum offer exceptionally good exposure, allowing radical excision in the case of early low-risk T1 adenocarcinomas (well or moderately differentiated [G1/2] without lymphovascular invasion [L0]).
  • From July 1987 to March 2006, 224 patients were treated by local excision for rectal lesions in our department.
  • In 3 patients with a preoperative diagnosis of severe dysplasia (Tis) final pathology showed adenoma and for this reason they were included in our study group.
  • Twenty-five (49%) patients had a definitive diagnosis of adenocarcinoma: in situ (pTis) in 22 patients (88%), pT1 in 2 patients (8%) and pT2 in 1 patient (4%).
  • In 26 patients (51%) the diagnosis was adenoma.
  • Giant sessile polypoid lesions localized in the middle and upper rectum are best treated with T.E.M., while Parks technique is a good option in lower rectal tumours.
  • [MeSH-major] Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Survival Rate

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  • (PMID = 18709772.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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60. Slosar M, Vohra P, Prasad M, Fischer A, Quinlan R, Khan A: Insulin-like growth factor mRNA binding protein 3 (IMP3) is differentially expressed in benign and malignant follicular patterned thyroid tumors. Endocr Pathol; 2009;20(3):149-57
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  • [Title] Insulin-like growth factor mRNA binding protein 3 (IMP3) is differentially expressed in benign and malignant follicular patterned thyroid tumors.
  • It is highly expressed in carcinomas of the pancreas, stomach, colon, rectum, kidneys, uterine cervix, lung, and ovary.
  • We immunostained 219 thyroid lesions selected from our surgical pathology archives including 14 hyperplastic colloid nodules (CN), 19 Hashimoto's thyroiditis (HT), two Graves disease (GD), ten Hürthle cell adenoma (HCA), 20 follicular adenoma (FA), 37 conventional papillary thyroid carcinoma (PTC), 60 follicular variant of papillary carcinoma (FVPC), 19 Hürthle cell carcinoma (HCC), 32 follicular carcinoma (FC), and six poorly differentiated/anaplastic carcinoma.
  • No significant correlation was found between pathologic tumor characteristics and IMP3 expression in differentiated follicular pattern thyroid carcinoma.
  • With 100% specificity and 69% sensitivity for FC as compared to FA and 100% specificity for FVPC, again compared to FA, IMP3 has the potential to be diagnostically useful in differentiating malignant and benign follicular pattern thyroid lesions.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Biomarkers, Tumor / analysis. Neoplasm Proteins / biosynthesis. RNA-Binding Proteins / biosynthesis. Thyroid Neoplasms / pathology

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  • (PMID = 19449140.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / IMP3 protein, human; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA-Binding Proteins
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61. Koo VS, Lynn NN, Saxby MF: Radical exenteration surgery is curative in locally advance mucinous prostatic adenocarcinoma involving bladder and rectum. J Surg Case Rep; 2010;2010(4):6
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  • [Title] Radical exenteration surgery is curative in locally advance mucinous prostatic adenocarcinoma involving bladder and rectum.
  • The management of mucinous prostatic adenocarcinoma include hormonal treatment, radiotherapy and radical prostatectomy with variable long-term outcome.
  • We report a 59 year old man with advanced mucinous prostatic adenocarcinoma involving almost the entire bladder and had failed treatment with hormonal and radiotherapy, but subsequently underwent radical pelvic exenteration surgery that resulted in long-term cure.

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  • [Copyright] © JSCR.
  • (PMID = 24946309.001).
  • [ISSN] 2042-8812
  • [Journal-full-title] Journal of surgical case reports
  • [ISO-abbreviation] J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3649112
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62. Oguz M, Bedirli A, Gultekin A, Dursun A, Mentes BB: Desmoid tumor arising at the colostomy site after abdominoperineal resection for rectal carcinoma: report of a case. Dis Colon Rectum; 2006 Sep;49(9):1445-8
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  • [Title] Desmoid tumor arising at the colostomy site after abdominoperineal resection for rectal carcinoma: report of a case.
  • A 69-year-old male who developed a desmoid tumor at the site of his end colostomy after abdominoperineal resection for rectal carcinoma is reported.
  • Histopathology revealed desmoid tumor of the anterior abdominal wall with no malignant features.
  • [MeSH-major] Abdominal Wall. Colostomy. Fibromatosis, Aggressive / pathology. Muscle Neoplasms / pathology. Neoplasms, Second Primary / pathology. Rectal Neoplasms / surgery
  • [MeSH-minor] Aged. Humans. Male. Rectum / surgery

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  • (PMID = 16897327.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Hsiung PL, Wang T: In vivo biomarkers for targeting colorectal neoplasms. Cancer Biomark; 2008;4(6):329-40
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  • Colorectal carcinoma continues to be a leading cause of cancer morbidity and mortality despite widespread adoption of screening methods.
  • Targeted detection and therapy using recent advances in our knowledge of in vivo cancer biomarkers promise to significantly improve methods for early detection, risk stratification, and therapeutic intervention.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Colorectal Neoplasms / diagnosis. Molecular Probe Techniques

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  • (PMID = 19126961.001).
  • [ISSN] 1574-0153
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK067618; United States / NIDDK NIH HHS / DK / K08 DK067618-06; United States / NIDDK NIH HHS / DK / R03 DK075603; United States / NIDDK NIH HHS / DK / R03 DK075603-03; United States / NCI NIH HHS / CA / R33 CA109988; United States / NCI NIH HHS / CA / R33 CA109988-05; United States / NCI NIH HHS / CA / U54 CA136429; United States / NCI NIH HHS / CA / U54 CA136429-05
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 68
  • [Other-IDs] NLM/ NIHMS336978; NLM/ PMC3232019
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64. Bianchi PP, Ceriani C, Locatelli A, Spinoglio G, Zampino MG, Sonzogni A, Crosta C, Andreoni B: Robotic versus laparoscopic total mesorectal excision for rectal cancer: a comparative analysis of oncological safety and short-term outcomes. Surg Endosc; 2010 Nov;24(11):2888-94
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  • [Title] Robotic versus laparoscopic total mesorectal excision for rectal cancer: a comparative analysis of oncological safety and short-term outcomes.
  • BACKGROUND: We assessed feasibility, short-term oncologic safety, and short-term outcomes in robotic total mesorectal excision (R-TME) for rectal cancer compared with laparoscopic TME.
  • METHODS: From March 2008 to June 2009, 50 patients with proven middle/lower rectal adenocarcinoma underwent minimally invasive TME; 25 received R-TME.
  • CONCLUSIONS: R-TME in rectal cancer is feasible, with short-term oncologic and other outcomes similar to those of L-TME.
  • [MeSH-major] Adenocarcinoma / surgery. Laparoscopy. Rectal Neoplasms / surgery. Rectum / surgery. Robotics

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  • [CommentIn] Surg Endosc. 2011 Dec;25(12):3954-6; author reply 3957-8 [21695585.001]
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  • (PMID = 20526623.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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65. Cabassa P, Morone M, Gatti E, Narbone M, Maroldi R: Gardner syndrome complicated with hydronephrosis. A case report. J Radiol Case Rep; 2010;4(3):19-23
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  • We present a case of a man who was admitted for a relapse of adenocarcinoma of the rectum.
  • CT-staging showed multiple locations of desmoid tumors and osteomas, with final diagnosis of Gardner syndrome.

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  • (PMID = 22470715.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303379
  • [Keywords] NOTNLM ; Gardner / computed tomography / desmoid tumors
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66. Toyooka M, Shoji Y: [A case of effective regimen of tegafur and uracil (UFT)/leucovorin (LV) plus irinotecan (CPT-11) for advanced rectal carcinoma with severe pelvic infiltration to be performed curative resection]. Gan To Kagaku Ryoho; 2007 Apr;34(4):635-8
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  • [Title] [A case of effective regimen of tegafur and uracil (UFT)/leucovorin (LV) plus irinotecan (CPT-11) for advanced rectal carcinoma with severe pelvic infiltration to be performed curative resection].
  • Computed tomography, barium enema and colonoscopy revealed a cysto-rectal fistula and massive invasion to middle rectum and retroperitoneal space from the main tumor in the upper rectum.
  • Therefore, oral administration of UFT/LV+CPT-11 was considered as effective neoadjuvant chemotherapy for advanced rectal carcinoma, and this also could be a promising regimen to maintain the quality of life (QOL) for patients in ambulatory therapy.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Pelvic Neoplasms / pathology. Rectal Neoplasms / drug therapy. Rectal Neoplasms / surgery
  • [MeSH-minor] Administration, Oral. Aged. Ambulatory Care. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Chemotherapy, Adjuvant. Drug Administration Schedule. Drug Combinations. Humans. Leucovorin / administration & dosage. Male. Neoadjuvant Therapy. Neoplasm Invasiveness. Quality of Life. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 17431356.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / UFT(R) drug; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; XT3Z54Z28A / Camptothecin
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67. Wu JH, Rong ZX, Zhu DJ, Chen XW, Ren BJ: [Laparoscopic anterior resection of rectal carcinoma with preservation of the left colonic artery]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 Jun;29(6):1249-50
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  • [Title] [Laparoscopic anterior resection of rectal carcinoma with preservation of the left colonic artery].
  • OBJECTIVE: To evaluate the feasibility and efficacy of laparoscopic anterior resection of rectal carcinoma with preservation of the left colonic artery.
  • METHODS: From February 2006 to February 2009, 52 patients with rectal carcinoma formerly scheduled for Dixon operation (clinical stage I and II) received laparoscopic Dixon surgery.
  • The inferior mesenteric artery, left colonic artery, sigmoid artery or superior rectal artery, and lymph nodes were dissected through the vasa vasorum approach.
  • None of the patients had perforation of the rectum, injuries to blood vessel, ureter or adjacent organs, or anastomotic tension.
  • The dissected lymph nodes in the base of the inferior mesenteric artery showed no cancer cell metastasis, while 4 patients had cancer cell metastasis in the lymph nodes surrounding superior rectal artery.
  • CONCLUSION: Laparoscopic anterior resection of the rectal carcinoma with preservation of the left colonic artery can be completed in patients with rectal carcinoma planning to receive Dixon operation (clinical stage I or II).
  • [MeSH-major] Colon / blood supply. Laparoscopy / methods. Mesenteric Artery, Inferior / surgery. Rectal Neoplasms / surgery

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  • (PMID = 19726377.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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68. Kam M, Massare J, Gallinger S, Kinzie J, Weaver D, Dingell JD, Esufali S, Bapat B, Tobi M: Peutz-Jeghers syndrome diagnosed in a schizophrenic patient with a large deletion in the STK11 gene. Dig Dis Sci; 2006 Sep;51(9):1567-70
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  • [MeSH-major] Peutz-Jeghers Syndrome / diagnosis. Peutz-Jeghers Syndrome / genetics. Protein-Serine-Threonine Kinases / genetics. Schizophrenia / complications. Sequence Deletion
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / therapy. Antineoplastic Agents / therapeutic use. Colectomy. Duodenal Neoplasms / pathology. Duodenal Neoplasms / therapy. Duodenoscopy. Genetic Linkage. Humans. Male. Middle Aged. RNA / blood. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16927138.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 63231-63-0 / RNA; EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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69. Kim CW, Kim JH, Yu CS, Shin US, Park JS, Jung KY, Kim TW, Yoon SN, Lim SB, Kim JC: Complications after sphincter-saving resection in rectal cancer patients according to whether chemoradiotherapy is performed before or after surgery. Int J Radiat Oncol Biol Phys; 2010 Sep 1;78(1):156-63
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  • [Title] Complications after sphincter-saving resection in rectal cancer patients according to whether chemoradiotherapy is performed before or after surgery.
  • PURPOSE: The aim of the present study was to compare the influence of preoperative chemoradiotherapy (CRT) with postoperative CRT on the incidence and types of postoperative complications in rectal cancer patients who underwent sphincter-saving resection.
  • RESULTS: There was no between-group difference in age, gender, or cancer stage.
  • [MeSH-major] Adenocarcinoma. Anal Canal / surgery. Neoadjuvant Therapy / methods. Postoperative Complications / etiology. Rectal Neoplasms
  • [MeSH-minor] Adult. Aged. Anastomosis, Surgical. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Capecitabine. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Drug Administration Schedule. Enteritis / etiology. Enteritis / surgery. Female. Fluorouracil / administration & dosage. Fluorouracil / analogs & derivatives. Humans. Ileostomy / statistics & numerical data. Intestinal Obstruction / etiology. Intestinal Obstruction / surgery. Korea. Leucovorin / administration & dosage. Male. Middle Aged. Multivariate Analysis. Preoperative Care. Radiotherapy Dosage. Rectal Fistula / etiology. Rectal Fistula / surgery. Rectovaginal Fistula / etiology. Rectovaginal Fistula / therapy. Rectum / surgery. Urinary Bladder Fistula / etiology. Urinary Bladder Fistula / surgery. Young Adult

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20106604.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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70. Fucini C, Pucciani F, Elbetti C, Gattai R, Russo A: Preoperative radiochemotherapy in t3 operable low rectal cancers: a gold standard? World J Surg; 2010 Jul;34(7):1609-14
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  • [Title] Preoperative radiochemotherapy in t3 operable low rectal cancers: a gold standard?
  • BACKGROUND: Preoperative chemoradiation followed by total mesorectal excision (TME) has become a standard treatment of preoperatively staged T3 low rectal cancers in many institutions; however, a direct comparison of generalized preoperative versus selective adjuvant chemoradiation has never been assessed in a clinical practice setting.
  • PATIENTS: Over a 4-year period, 80 patients with T3 primary low adenocarcinoma of the rectum, judged operable at preoperative staging, were offered preoperative chemoradiation.
  • CONCLUSIONS: In T3 operable low rectal cancers, selective postoperative radiochemotherapy yielded similar long-term results regarding recurrence rate and survival as extended preoperative chemoradiation.
  • [MeSH-major] Adenocarcinoma / surgery. Neoadjuvant Therapy. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Humans. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Postoperative Complications / epidemiology. Radiotherapy Dosage. Radiotherapy, Adjuvant

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  • (PMID = 20213202.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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71. Okamoto T, Toné S, Kanouchi H, Miyawaki C, Ono S, Minatogawa Y: Transcriptional regulation of indoleamine 2,3-dioxygenase (IDO) by tryptophan and its analogue : Down-regulation of the indoleamine 2,3-dioxygenase (IDO) transcription by tryptophan and its analogue. Cytotechnology; 2007 Jun;54(2):107-13
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  • This enzyme is induced by IFN-gamma in the mouse rectal carcinoma cell line CMT-93.

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  • (PMID = 19003025.001).
  • [ISSN] 0920-9069
  • [Journal-full-title] Cytotechnology
  • [ISO-abbreviation] Cytotechnology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2267499
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72. Kibil W, Kłek S, Gurda-Duda A, Kopciński P, Kulig J: [The value of endorectal ultrasound (ERUS) in the assessment of the clinical severity of ulcerative colitis]. Przegl Lek; 2007;64(1):5-8
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  • AIM: Endorectal ultrasonography (ERUS) represents a relatively new diagnostic tool enabling easy and precise assessment of rectal wall lesions, used mostly in diagnosing of the carcinoma of the rectum.
  • [MeSH-major] Colitis, Ulcerative / ultrasonography. Endosonography. Rectum / ultrasonography

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  • (PMID = 18183824.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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73. Huh JW, Kim YJ, Kim HR: Complete peritonectomy and intraperitoneal chemotherapy for recurrent rectal cancer with peritoneal metastasis. World J Gastroenterol; 2009 Feb 14;15(6):756-7
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  • [Title] Complete peritonectomy and intraperitoneal chemotherapy for recurrent rectal cancer with peritoneal metastasis.
  • A 68-year-old man underwent laparoscopic low anterior resection for rectal carcinoma in December 2006.
  • Nearly 19 mo after the operation, he developed recurrent rectal cancer with peritoneal metastasis.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / surgery. Organoplatinum Compounds / therapeutic use. Peritoneal Neoplasms / secondary. Rectal Neoplasms / drug therapy. Rectal Neoplasms / surgery
  • [MeSH-minor] Aged. Combined Modality Therapy. Fluorouracil / therapeutic use. Humans. Laparoscopy. Leucovorin / therapeutic use. Male. Neoplasm Metastasis / drug therapy. Treatment Outcome

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  • (PMID = 19222104.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
  • [Other-IDs] NLM/ PMC2653448
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74. Chen KY, Xiang GA, Wang HN, Xiao FL: [Simultaneous laparoscopic excision for the treatment of rectal carcinoma and the synchronous hepatic metastasis]. Zhonghua Zhong Liu Za Zhi; 2009 Jan;31(1):69-71
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  • [Title] [Simultaneous laparoscopic excision for the treatment of rectal carcinoma and the synchronous hepatic metastasis].
  • OBJECTIVE: To evaluate the therapeutic efficacy of simultaneous laparoscopic excision for the treatment of rectal carcinoma and synchronous hepatic metastasis.
  • METHODS: Totally 38 patients with rectal carcinoma and synchronous hepatic metastasis detected by CT scan were included in this study.
  • Among them, 23 patients in the group A were treated with laparoscopic surgery, and the other 18 patients in the group B with traditional abdominal operation to resect the rectal tumor and hepatic metastasis simultaneously.
  • CONCLUSION: Simultaneous laparoscopic excision of rectal carcinoma and synchronous hepatic metastasis is safe, effective and minimally invasive with a similar survival achieved by traditional open abdominal operation.
  • [MeSH-major] Adenocarcinoma / surgery. Laparoscopy / methods. Liver Neoplasms / surgery. Rectal Neoplasms / surgery

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  • (PMID = 19538876.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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75. Basu KS, Bahl A, Subramani V, Sharma DN, Rath GK, Julka PK: Normal tissue complication probability: does simultaneous integrated boost intensity-modulated radiotherapy score over other techniques in treatment of prostate adenocarcinoma. J Cancer Res Ther; 2009 Apr-Jun;5(2):78-84
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  • [Title] Normal tissue complication probability: does simultaneous integrated boost intensity-modulated radiotherapy score over other techniques in treatment of prostate adenocarcinoma.
  • AIM: The main objective of this study was to analyze the radiobiological effect of different treatment strategies on high-risk prostate adenocarcinoma.
  • MATERIALS AND METHODS: Ten cases of high-risk prostate adenocarcinoma were selected for this dosimetric study.
  • Four different treatment strategies used for treating prostate cancer were compared.
  • RESULTS: An NTCP of 10.7 +/- 0.99%, 8.36 +/- 0.66%, 6.72 +/- 0.85%, and 1.45 +/- 0.11% for the bladder and 14.9 +/- 0.99%, 14.04 +/- 0.66%, 11.38 +/- 0.85%, 5.12 +/- 0.11% for the rectum was seen with 3D + 3DCRT, 3D + IMRT, IMRT + IMRT, and SIBIMRT respectively.
  • It should be the technique of choice for dose escalation in prostate carcinoma.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Probability. Prostatic Neoplasms / radiotherapy

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  • (PMID = 19542662.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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76. van Baardewijk LJ, Idenburg FJ, Clahsen PC, Möllers MJ: [Von Meyenburg complexes in the liver: not metastases]. Ned Tijdschr Geneeskd; 2010;154:A1674
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  • A 74-year-old woman underwent a laparotomy for a rectal carcinoma.
  • Intraoperative frozen section analysis to differentiate between malignant and benign lesions has a sensitivity of 97% and a specificity of 99%.
  • The patient underwent total mesorectal excision and follow-up after 3, 7 and 9 months did not reveal any indications of recurrent colorectal cancer or metastases.
  • [MeSH-major] Hamartoma / diagnosis. Liver Diseases / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Aged. Bile Ducts / abnormalities. Bile Ducts / pathology. Carcinoma / pathology. Carcinoma / surgery. Diagnosis, Differential. Female. Humans. Incidental Findings. Liver / pathology. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / pathology. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery

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  • (PMID = 20619020.001).
  • [ISSN] 1876-8784
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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77. Wells BJ, Stotland P, Ko MA, Al-Sukhni W, Wunder J, Ferguson P, Lipa J, Last L, Smith AJ, Swallow CJ: Results of an aggressive approach to resection of locally recurrent rectal cancer. Ann Surg Oncol; 2007 Feb;14(2):390-5
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  • [Title] Results of an aggressive approach to resection of locally recurrent rectal cancer.
  • BACKGROUND: The value of resection for locally recurrent rectal cancer (LRRC) remains controversial.
  • [MeSH-major] Adenocarcinoma / surgery. Colectomy / mortality. Neoplasm Recurrence, Local / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Rectum / pathology. Rectum / surgery. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17063304.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Wentink MQ, Räkers M, Stupart DA, Algar U, Ramesar R, Goldberg PA: Incidence and histological features of colorectal cancer in the Northern Cape Province, South Africa. S Afr J Surg; 2010 Nov;48(4):109-13
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  • [Title] Incidence and histological features of colorectal cancer in the Northern Cape Province, South Africa.
  • AIM: The purpose of this study was to determine the incidence of colorectal cancer (CRC) in the Northern Cape province of South Africa, and to identify patients with histological and demographic features suggestive of hereditary non-polyposis colon cancer (HNPCC).
  • METHOD: This is a retrospective review of all cases of primary adenocarcinoma of the colon or rectum diagnosed by the two pathology laboratories operating in the Northern Cape between January 2002 and February 2009.
  • The median age at which colorectal cancer was diagnosed was 59 years (range 16-90 years).
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Colorectal Neoplasms, Hereditary Nonpolyposis / epidemiology. Colorectal Neoplasms, Hereditary Nonpolyposis / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Incidence. Male. Microsatellite Instability. Middle Aged. Neoplasm Staging. Retrospective Studies. South Africa / epidemiology. Statistics, Nonparametric

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  • (PMID = 21542398.001).
  • [ISSN] 0038-2361
  • [Journal-full-title] South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie
  • [ISO-abbreviation] S Afr J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] South Africa
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79. Valentini V, Morganti AG, Gambacorta MA, Mohiuddin M, Doglietto GB, Coco C, De Paoli A, Rossi C, Di Russo A, Valvo F, Bolzicco G, Dalla Palma M, Study Group for Therapies of Rectal Malignancies (STORM): Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: A multicentric phase II study. Int J Radiat Oncol Biol Phys; 2006 Mar 15;64(4):1129-39
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  • [Title] Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: A multicentric phase II study.
  • PURPOSE: The combination of irradiation and total mesorectal excision for rectal carcinoma has significantly lowered the incidence of local recurrence.
  • However, a new problem is represented by the patient with locally recurrent cancer who has received previous irradiation to the pelvis.
  • The aim of this multicenter phase II study is to evaluate the response rate, resectability rate, local control, and treatment-related toxicity of preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis.
  • METHODS AND MATERIALS: Patients with histologically proven pelvic recurrence of rectal carcinoma, with the absence of extrapelvic disease or bony involvement and previous pelvic irradiation with doses < or =55 Gy; age > or =18 years; performance status (PS) (Karnofsky) > or =60, and who gave institutional review board-approved written informed consent were treated by preoperative chemoradiation.
  • [MeSH-major] Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / radiotherapy. Rectal Neoplasms / drug therapy. Rectal Neoplasms / radiotherapy

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  • (PMID = 16414206.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Quinazolines; 0 / Thiophenes; FCB9EGG971 / raltitrexed; U3P01618RT / Fluorouracil
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80. Lotter O, Amr A, Safi F: Prognostic significance of p53-expression in colorectal carcinoma as measured by a luminometric immunoassay. Ger Med Sci; 2010;8:Doc24
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  • [Title] Prognostic significance of p53-expression in colorectal carcinoma as measured by a luminometric immunoassay.
  • In the following study we examined if elevated levels of p53 correlate with worse prognosis in colorectal cancer.
  • METHODS: We have quantified the protein, using an immunoluminometric assay, in 144 cytosols of primary sporadic colorectal cancer tissues and in 96 specimen of normal mucosa.
  • CONCLUSION: Our investigation revealed that p53-overexpression as measured by a luminometric immunoassay, is not a useful predictor of prognosis in patients with colorectal adenocarcinoma.

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  • (PMID = 21063465.001).
  • [ISSN] 1612-3174
  • [Journal-full-title] German medical science : GMS e-journal
  • [ISO-abbreviation] Ger Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Luminescent Proteins; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC2975257
  • [Keywords] NOTNLM ; colorectal cancer / p53-protein / prognosis / tumor markers
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81. Cao J, Xia J, Wang H, DU H, Li WL: [Fragile histidine triad protein expression and correlation with apoptosis in rectal carcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Mar;10(2):177-81
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  • [Title] [Fragile histidine triad protein expression and correlation with apoptosis in rectal carcinoma].
  • OBJECTIVE: To investigate the relationship between the expression of fragile histidine triad (FHIT) protein and the clinicopathological characteristics of rectal carcinoma.
  • The relationship between FHIT protein expression and Bcl-2, Bax and survivin expression, as well as cell apoptosis in rectal carcinoma were explored.
  • METHODS: Tissue microarray and immunohistochemistry SP were used to detect the expression of FHIT, Bcl-2, Bax and Survivin in 16 cases of normal rectal tissue, 16 cases of rectal adenoma and 80 cases of rectal carcinoma.
  • TUNEL was used to detect apoptosis index (AI) in 80 cases of rectal carcinoma.
  • RESULTS: The positive rates of FHIT expression in normal rectal tissue, rectal adenoma and adenocarcinoma were 93.8%, 75.0% and 46.3% respectively.
  • The expression of FHIT was positively correlated with that of Bcl-2, Bax and survivin in rectal cancer.
  • CONCLUSIONS: The reduction of FHIT protein expression may play an important role in the development of rectal carcinoma, and FHIT protein may be associated with the regulation of cell apoptosis.
  • [MeSH-major] Acid Anhydride Hydrolases / metabolism. Apoptosis. Neoplasm Proteins / metabolism. Rectal Neoplasms / metabolism. Rectal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Inhibitor of Apoptosis Proteins. Lymphatic Metastasis. Male. Microtubule-Associated Proteins / metabolism. Middle Aged. Neoplasm Staging. Protein Array Analysis. bcl-2-Associated X Protein / metabolism

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  • (PMID = 17380463.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / bcl-2-Associated X Protein; 0 / fragile histidine triad protein; EC 3.6.- / Acid Anhydride Hydrolases
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82. Gordon MA, Gil J, Lu B, Zhang W, Yang D, Yun J, Schneider S, Groshen S, Iqbal S, Press OA, Rhodes K, Lenz HJ: Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation. Pharmacogenomics; 2006 Jan;7(1):67-88
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  • [Title] Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation.
  • PURPOSE: Stage II and III adenocarcinoma of the rectum has an overall 5-year survival rate of approximately 50%, and tumor recurrence remains a major problem despite an improvement in local control through chemotherapy and radiation.
  • In this study, we tested whether a specific pattern of 21 polymorphisms in 18 genes involved in the critical pathways of cancer progression (i.e., drug metabolism, tumor microenvironment, cell cycle regulation, and DNA repair) will predict the risk of tumor recurrence in rectal cancer patients treated with chemoradiation.
  • PATIENTS AND METHODS: A total of 90 patients with Stage II or III rectal cancer treated with chemoradiation were genotyped using polymerase chain reaction (PCR)-based techniques for 21 polymorphisms.
  • A larger prospective study is needed to validate these preliminary data using germline polymorphisms on tumor recurrences in rectal cancer patients treated with chemoradiation.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Gene Expression Profiling. Rectal Neoplasms / genetics

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  • (PMID = 16354126.001).
  • [ISSN] 1462-2416
  • [Journal-full-title] Pharmacogenomics
  • [ISO-abbreviation] Pharmacogenomics
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K24CA8275401; United States / NCI NIH HHS / CA / P30CA14039; United States / NCI NIH HHS / CA / R01CA105145; United States / NCI NIH HHS / CA / R01CA82655
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / DNA-Binding Proteins; 0 / Interleukin-8; 0 / Transforming Growth Factor beta; 0 / X-ray repair cross complementing protein 3; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.5.1.18 / GSTP1 protein, human; EC 2.5.1.18 / Glutathione S-Transferase pi; EC 3.1.- / ERCC1 protein, human; EC 3.1.- / Endonucleases
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83. Balbinotti RA, Ribeiro U Jr, Sakai P, Safatle-Ribeiro AV, Balbinotti SS, Scapulatempo C, Alves VA, Corbett CE, Carrilho FJ: hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps. Anticancer Res; 2007 Nov-Dec;27(6C):4465-71
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  • Mutations in the mismatch repair (MMR) enzymes hMLH1, hMSH2 and hMSH6 are recognized causes of hereditary non-polyposis colorectal cancer and act by inducing a mutator phenotype characterized by microsatellite instability (MSI).
  • Cox-2 is an inducible enzyme that regulates prostaglandin synthesis and it is overexpressed at sites of inflammation, in colorectal adenomatous polyps and cancer.
  • PATIENTS AND METHODS: One hundred and sixty-seven colonic polyps, 6 normal colonic mucosa samples, and 23 samples of colorectal adenocarcinoma were used in this study.
  • All patients had no family history of colorectal cancer.
  • CONCLUSION: Loss of hMLH1 and hMLH2 immunoexpression in adenomas is relatively frequent in patients without colorectal cancer family history.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adult. Aged. Aged, 80 and over. Colorectal Neoplasms / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged. Rectum / pathology

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  • (PMID = 18214062.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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84. Parikh JH, Barton DP, Ind TE, Sohaib SA: MR imaging features of vaginal malignancies. Radiographics; 2008 Jan-Feb;28(1):49-63; quiz 322
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  • Squamous cell carcinoma makes up about 85% of primary vaginal malignancies.
  • At magnetic resonance (MR) imaging, squamous cell carcinoma has intermediate signal intensity on T2-weighted images and low signal intensity on T1-weighted images.
  • The tumors that account for the remaining 15% of primary vaginal malignancies are adenocarcinoma, melanoma, and sarcomas.
  • Most vaginal metastases occur by means of direct local spread from the cervix, uterus, or rectum.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Image Enhancement / methods. Magnetic Resonance Imaging / methods. Vagina / pathology. Vaginal Neoplasms / diagnosis

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  • (PMID = 18203930.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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85. Zheng YL, Yin XY, Xie XY, Xu HX, Xu ZF, Liu GJ, Liang JY, Lu MD: Value of contrast-enhanced ultrasonography in assessing the vascularity of liver metastases: comparison with contrast-enhanced computed tomography. J Ultrasound Med; 2010 Oct;29(10):1403-10
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  • METHODS: Both CEUS and CECT examinations were performed on 70 patients with liver metastases, which were from colon carcinoma in 31, rectal carcinoma in 17, pancreatic carcinoma in 5, and others in 17.
  • [MeSH-minor] Adult. Aged. Colonic Neoplasms / pathology. Female. Humans. Image Enhancement. Image Processing, Computer-Assisted. Male. Middle Aged. Pancreatic Neoplasms / pathology. Phospholipids. Radiographic Image Enhancement / methods. Rectal Neoplasms / pathology. Sulfur Hexafluoride. Tomography, X-Ray Computed / methods. Ultrasonography, Interventional / methods

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  • (PMID = 20876893.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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86. Schneider AR, Seifert H, Trojan J, Stein J, Hoepffner NM: Frequency of colorectal polyps in patients with sporadic adenomas or adenocarcinomas of the papilla of vater--an age-matched, controlled study. Z Gastroenterol; 2005 Oct;43(10):1123-7
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  • The carcinogenesis of these tumors seems to be fairly analogous to the genetic mechanisms which have been described for colorectal carcinoma.
  • Colonoscopy detected rectal carcinoma in 2 patients (8%) of the study group.
  • However, the finding of 2 rectal carcinomas among patients with ampullary neoplasms supports the place of screening colonoscopy for the diagnostic work-up of ampullary tumors.
  • [MeSH-major] Adenocarcinoma / complications. Adenoma / complications. Ampulla of Vater. Common Bile Duct Neoplasms / complications. Intestinal Polyps / epidemiology
  • [MeSH-minor] Adenoma, Villous / complications. Adenoma, Villous / surgery. Adenomatous Polyposis Coli / epidemiology. Adult. Aged. Aged, 80 and over. Colonic Polyps / diagnosis. Colonic Polyps / epidemiology. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology. Data Interpretation, Statistical. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Risk Factors. Time Factors

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  • (PMID = 16220451.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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87. Mäkelä JT, Kiviniemi H: Clinicopathological features of colorectal cancer in patients under 40 years of age. Int J Colorectal Dis; 2010 Jul;25(7):823-8
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  • [Title] Clinicopathological features of colorectal cancer in patients under 40 years of age.
  • OBJECTIVE: The aim was to identify the clinical factors and tumour characteristics that predict survival in patients younger than 40 years with colorectal adenocarcinoma.
  • MATERIAL AND METHODS: Fifty-nine patients with colorectal cancer aged under 40 years were identified from a computer database, and their clinical variables were analysed.
  • RESULTS: The prevalence of positive family history of cancer was 27%, and predisposing factors were present in 31% of the patients.
  • The cumulative 5-year survival of men, 45%, was significantly worse than that of women, 73%, and this phenomenon was closely related to more distended lymphatic and venous invasion of cancer in men.
  • CONCLUSIONS: Young men with colorectal cancer in Northern Finland have poorer prognosis than women.

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  • (PMID = 20217423.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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88. Maslekar S, Sharma A, Macdonald A, Gunn J, Monson JR, Hartley JE: Mesorectal grades predict recurrences after curative resection for rectal cancer. Dis Colon Rectum; 2007 Feb;50(2):168-75
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  • [Title] Mesorectal grades predict recurrences after curative resection for rectal cancer.
  • PURPOSE: Local recurrence after curative excision for rectal cancer is frequently regarded as a failure of surgery.
  • METHODS: All patients undergoing resection for primary adenocarcinoma of the rectum had a mesorectal grading prospectively applied to their resection specimens, according to the classification proposed by Quirke et al. (Grades 1-3; 3 is the best).
  • CONCLUSIONS: The macroscopic quality of mesorectum after curative excision of rectal cancer is an important predictor of local and overall recurrences.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Digestive System Surgical Procedures / methods. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Predictive Value of Tests. Proportional Hazards Models. Prospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17160574.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Lahat A, Yanai H, Sakhnini E, Menachem Y, Bar-Meir S: Role of colonoscopy in patients with persistent acute diverticulitis. World J Gastroenterol; 2008 May 7;14(17):2763-6
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  • RESULTS: Three hundred and six patients were hospitalized between July 2000 and December 2006 with the diagnosis of acute diverticulitis.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Colonoscopy. Diverticulitis, Colonic / pathology. Foreign-Body Reaction / pathology

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  • (PMID = 18461662.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Other-IDs] NLM/ PMC2709057
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90. Baća I, Perko Z, Bokan I, Mimica Z, Petricević A, Druzijanić N, Situm M: Technique and survival after laparoscopically assisted right hemicolectomy. Surg Endosc; 2005 May;19(5):650-5
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  • BACKGROUND: The role of laparoscopic colon resection in the management of colon cancer is still controversial.
  • METHODS: Between March 1993 and July 2003, we performed laparoscopic right hemicolectomy in 56 patients with right colon carcinoma.
  • CONCLUSIONS: Our results show that laparoscopic right hemicolectomy for colon cancer can be performed safely.
  • [MeSH-major] Adenocarcinoma / surgery. Colectomy / methods. Colonic Neoplasms / surgery. Laparoscopy / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Colitis / surgery. Colonic Polyps / surgery. Disease-Free Survival. Female. Humans. Life Tables. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Postoperative Complications / epidemiology. Prognosis. Proportional Hazards Models. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 15776206.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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91. Langholz E: Current trends in inflammatory bowel disease: the natural history. Therap Adv Gastroenterol; 2010 Mar;3(2):77-86
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  • At diagnosis behaviour is inflammatory in 70% of patients.
  • The incidence of colorectal cancer (CRC) in UC seems to be decreasing.
  • Patients with small bowel CD are also at increased risk of small bowel adenocarcinoma.
  • Further studies are needed to develop the best strategy for the reduction of mortality and cancer risk in IBD.

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  • (PMID = 21180592.001).
  • [ISSN] 1756-2848
  • [Journal-full-title] Therapeutic advances in gastroenterology
  • [ISO-abbreviation] Therap Adv Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3002570
  • [Keywords] NOTNLM ; colorectal cancer / disease course / epidemiology / inflammatory bowel disease / mortality / prognosis
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92. Miki C, Inoue Y, Hiro J, Ojima E, Araki T, Uchida K, Kusunoki M: Combined measurement of hepatocyte growth factor and carcinoembryonic antigen as a prognostic marker for patients with dukes a and B colorectal cancer: results of a five-year study. Dis Colon Rectum; 2006 Nov;49(11):1710-8
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  • [Title] Combined measurement of hepatocyte growth factor and carcinoembryonic antigen as a prognostic marker for patients with dukes a and B colorectal cancer: results of a five-year study.
  • PURPOSE: There is no marker capable of differentiating patients with Dukes A and B colorectal cancer with aggressive diseases from those with indolent diseases.
  • METHODS: Blood samples of 147 colorectal cancer patients were obtained and the serum concentration of hepatocyte growth factor was measured.
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Aged. Biomarkers / blood. Female. Humans. Japan / epidemiology. Liver Neoplasms / secondary. Lymphatic Metastasis. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / blood. Prognosis. Survival Analysis

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  • (PMID = 16990975.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Carcinoembryonic Antigen; 67256-21-7 / Hepatocyte Growth Factor
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93. Bakx R, Emous M, Legemate DA, Machado M, Zoetmulder FA, van Tets WF, Bemelman WA, Slors JF, van Lanschot JJ: Categorization of major and minor complications in the treatment of patients with resectable rectal cancer using short-term pre-operative radiotherapy and total mesorectal excision: a Delphi round. Colorectal Dis; 2006 May;8(4):302-8
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  • [Title] Categorization of major and minor complications in the treatment of patients with resectable rectal cancer using short-term pre-operative radiotherapy and total mesorectal excision: a Delphi round.
  • BACKGROUND: To properly balance the benefit (reduction of local recurrence) of short-term pre-operative radiotherapy for resectable rectal cancer against its harm (complications), a consensus concerning the severity of complications is required.
  • The aim of this study was to reach consensus regarding major and minor complications after short-term radiotherapy followed by total mesorectal excision in the treatment of rectal carcinoma, using the Delphi technique.
  • METHODS: A Delphi round was performed in cooperation with 21 colo-rectal surgeons from the Netherlands, United Kingdom and Sweden.
  • The key-question was: 'Which of the predefined complications, caused or substantially aggravated by radiotherapy, are so important (major) that they might lead to the decision to abandon short-term pre-operative radiotherapy (5 x 5Gy) when treating patients with resectable rectal cancer (T1-3N0-2M0)?
  • CONCLUSION: The 13 major and three 'accepted as major' complications can be used to properly balance the benefit and harm of short-term pre-operative radiotherapy in resectable rectal cancer.
  • [MeSH-major] Colorectal Surgery. Consensus. Expert Testimony. Neoadjuvant Therapy / adverse effects. Radiotherapy, Adjuvant / adverse effects. Rectal Neoplasms / radiotherapy

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  • (PMID = 16630234.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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94. de Bruin EC, van de Pas S, Lips EH, van Eijk R, van der Zee MM, Lombaerts M, van Wezel T, Marijnen CA, van Krieken JH, Medema JP, van de Velde CJ, Eilers PH, Peltenburg LT: Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles. BMC Genomics; 2005;6:142
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  • [Title] Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles.
  • However, the presence of stroma cells in surgically excised carcinoma tissues might obscure the tumor cell-specific gene expression profiles of these samples.
  • In this report, we compared RNAs isolated from macrodissected, of which only surrounding healthy tissue had been removed, and microdissected rectal carcinoma samples by microarray analysis in order to determine the most reliable approach to detect the expression of tumor cell-derived genes by microarray analysis.
  • [MeSH-major] Gene Expression Regulation. Gene Expression Regulation, Neoplastic. Microdissection / methods. Rectal Neoplasms / diagnosis. Rectal Neoplasms / pathology
  • [MeSH-minor] Carcinoma / metabolism. Cluster Analysis. DNA, Complementary / metabolism. Gene Expression Profiling. Humans. Microarray Analysis. RNA / metabolism. RNA, Messenger / metabolism. RNA, Neoplasm / metabolism. Software. Stromal Cells / metabolism

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  • (PMID = 16225673.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 63231-63-0 / RNA
  • [Other-IDs] NLM/ PMC1283972
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95. Tateishi S, Arima S, Futami K, Kawahara K, Tachikawa D, Naritomi K, Iwashita A: A clinicopathological investigation of "tumor nodules" in colorectal cancer. Surg Today; 2005;35(5):377-84
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  • [Title] A clinicopathological investigation of "tumor nodules" in colorectal cancer.
  • The TNM classification of malignant tumors provides a description of how to deal with tn, but there has so far been no description within the Japanese classification of colorectal carcinoma.
  • METHODS: A total of 544 patients who underwent a resection of colorectal adenocarcinoma between 1985 and 1995 were reviewed.
  • RESULTS: Tumor nodules were found in 54 (17.6%) of 307 colon cancer patients, and in 41 (17.3%) of 237 rectal cancer patients.
  • We classified the curability A patients into four groups for both colon and rectal cancer; positive lymph nodes with tn (Group A), negative lymph nodes with tn (Group B), positive lymph nodes without tn (Group C), and negative lymph nodes without tn (Group D).
  • The prognosis was not significantly different between Groups A, B, and C, but it was significantly different between Group D and Groups A, B, and C (P < 0.01) in both the colon and the rectum.
  • [MeSH-major] Adenocarcinoma / pathology. Colorectal Neoplasms / pathology. Lymph Nodes / pathology

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  • [CommentIn] Surg Today. 2006;36(10):944-5 [16998694.001]
  • (PMID = 15864419.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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96. Artifon EL, Sakai P, Ishioka S, Silva AF, Maluf F, Chaves D, Matuguma S, Pompeo A, Lucon AM, Srougi M, Bhutani MS: EUS for locoregional staging of prostate cancer--a pilot study. Gastrointest Endosc; 2007 Mar;65(3):440-7
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  • [Title] EUS for locoregional staging of prostate cancer--a pilot study.
  • BACKGROUND: This was a pilot study on EUS for locoregional evaluation of prostate cancer.
  • OBJECTIVE: Our purpose was to evaluate radial and linear-array EUS in locoregional prostate cancer staging.
  • DESIGN, SETTING, PATIENTS: From April to December 2005, 23 patients were referred to the Department of Urology with a confirmed or highly suspected diagnosis of prostate cancer on the basis of cytohistologic examination of fragments obtained by transrectal US-guided biopsy or transuretheral means.
  • INTERVENTION: An endosonographer and a radiologist with expertise in prostate imaging performed radial and linear EUS examinations without knowledge of the stage of prostate cancer of the referred patients.
  • Histopathologic study of the surgical specimen revealed adenocarcinoma in 20 of 23, atypical adenomatous hyperplasia in 2 of 23, and sclerosing adenosis in 1 of 23.
  • In 3 (3/23) patients EUS did not find a defined lesion, but the surgical specimen showed T1 stage cancer.
  • CONCLUSIONS: EUS presented high sensitivity, specificity, and accuracy for prostate cancer staging.
  • [MeSH-major] Adenocarcinoma / ultrasonography. Endosonography / methods. Prostatic Neoplasms / ultrasonography
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Equipment Design. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging / methods. Pilot Projects. Prostatectomy. Rectum. Retrospective Studies. Sensitivity and Specificity. Urethra

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  • (PMID = 17321246.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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97. Hohenberger W, Bittorf B, Papadopoulos T, Merkel S: Survival after surgical treatment of cancer of the rectum. Langenbecks Arch Surg; 2005 Sep;390(5):363-72
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  • [Title] Survival after surgical treatment of cancer of the rectum.
  • BACKGROUND AND AIMS: Rectal carcinoma is one of the most prevalent tumour types.
  • PATIENTS/METHODS: The data of 1,067 consecutive patients with solitary invasive rectal carcinoma, resected between 1988 and 1999 at the Department of Surgery of the University of Erlangen, were analysed.
  • Cancer-related survival rate was calculated by univariate and multivariate analysis with respect to all relevant proven and probable prognostic factors.
  • RESULTS: The R classification was found to be the parameter with the greatest influence on survival of patients with rectal carcinoma.
  • The increasing survival rates after treatment of rectal carcinoma have led to a focus on postoperative quality of life.
  • [MeSH-major] Carcinoma / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Quality of Life. Survival Rate

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  • (PMID = 15309541.001).
  • [ISSN] 1435-2443
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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98. Kitano S, Shiraishi N, Uyama I, Sugihara K, Tanigawa N, Japanese Laparoscopic Surgery Study Group: A multicenter study on oncologic outcome of laparoscopic gastrectomy for early cancer in Japan. Ann Surg; 2007 Jan;245(1):68-72
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  • [Title] A multicenter study on oncologic outcome of laparoscopic gastrectomy for early cancer in Japan.
  • BACKGROUND: Laparoscopic surgery for gastric cancer is technically feasible, but it is not widely accepted because it has not been evaluated from the standpoint of oncologic outcome.
  • We conducted a retrospective, multicenter study of a large series of patients in Japan to evaluate the short- and long-term outcomes of laparoscopic gastrectomy for early gastric cancer (EGC).
  • Cancer recurred in only 6 (0.6%) of 1294 patients treated curatively (median follow-up, 36 months; range, 13-113 months).
  • [MeSH-major] Adenocarcinoma / surgery. Gastrectomy / methods. Laparoscopy. Stomach Neoplasms / surgery

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  • (PMID = 17197967.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1867926
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99. Chialina SG, Fornes C, Landi C, de la Vega Elena CD, Nicolorich MV, Dourisboure RJ, Solano A, Solis EA: Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue. BMC Med Genet; 2006;7:5
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  • [Title] Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue.
  • BACKGROUND: Hereditary non-polyposis colon cancer (HNPCC) is an autosomal dominant syndrome predisposing to the early development of various cancers including those of colon, rectum, endometrium, ovarium, small bowel, stomach and urinary tract.
  • In this study, we report the analysis for genetic counseling of three first-degree relatives (the mother and two sisters) of a male who died of colorectal adenocarcinoma at the age of 23.
  • METHODS: Tumor MSI testing is described as initial screening in both primary and metastasis tumor tissue blocks, using the reference panel of 5 microsatellite markers standardized by the National Cancer Institute (NCI) for the screening of HNPCC (BAT-25, BAT-26, D2S123, D5S346 and D17S250).
  • [MeSH-major] Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis. DNA Mutational Analysis / methods. Germ-Line Mutation. Microsatellite Repeats. MutS Homolog 2 Protein / genetics

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  • (PMID = 16426447.001).
  • [ISSN] 1471-2350
  • [Journal-full-title] BMC medical genetics
  • [ISO-abbreviation] BMC Med. Genet.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
  • [Other-IDs] NLM/ PMC1373649
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100. Park IJ, Choi GS, Lim KH, Kang BM, Jun SH: Laparoscopic resection of extraperitoneal rectal cancer: a comparative analysis with open resection. Surg Endosc; 2009 Aug;23(8):1818-24
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  • [Title] Laparoscopic resection of extraperitoneal rectal cancer: a comparative analysis with open resection.
  • PURPOSE: The aim of this study was to compare the outcomes of laparoscopic surgery with those of open resection in patients with extraperitoneal rectal cancer.
  • METHODS: Five hundred forty-four patients with extraperitoneal rectal cancer who underwent curative resection between 1996 and 2007 were included.
  • CONCLUSIONS: The results of this study show that laparoscopic resection of extraperitoneal rectal cancer was safe and effective.
  • [MeSH-major] Adenocarcinoma / surgery. Laparoscopy. Laparotomy. Rectal Neoplasms / surgery
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease Progression. Disease-Free Survival. Elective Surgical Procedures. Female. Fluorouracil / administration & dosage. Follow-Up Studies. Humans. Levamisole / administration & dosage. Male. Middle Aged. Neoplasm Invasiveness. Postoperative Complications / epidemiology. Prospective Studies. Radiotherapy, Adjuvant. Tegafur / administration & dosage. Treatment Outcome

  • Genetic Alliance. consumer health - Rectal Cancer.
  • Hazardous Substances Data Bank. FLUOROURACIL .
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  • [CommentIn] Surg Endosc. 2011 Feb;25(2):658-60 [20632188.001]
  • [CommentIn] Surg Endosc. 2009 Dec;23(12):2871-3 [19688396.001]
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  • (PMID = 19118433.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 2880D3468G / Levamisole; U3P01618RT / Fluorouracil
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