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[Title] Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model.

Since it was recently proposed as a potential prostate cancer chemopreventive agent, we here performed an in vivo experiment to explore its effect in the Transgenic Rat for Adenocarcinoma of Prostate (TRAP) model, featuring the rat probasin promoter/SV 40 T antigen.

Resveratrol suppressed prostate cancer growth and induction of apoptosis through androgen receptor (AR) down-regulation, without any sign of toxicity.

Resveratrol not only downregulated androgen receptor (AR) expression but also suppressed the androgen responsive glandular kallikrein 11 (Gk11), known to be an ortholog of the human prostate specific antigen (PSA), at the mRNA level.

The data provide a mechanistic basis for resveratrol chemopreventive efficacy against prostate cancer.

[MeSH-major] Adenocarcinoma / drug therapy. Anticarcinogenic Agents / therapeutic use. Disease Models, Animal. Prostatic Neoplasms / drug therapy. Stilbenes / therapeutic use

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(PMID = 18439064.001).

[ISSN] 2476-762X

[Journal-full-title] Asian Pacific journal of cancer prevention : APJCP

[ISO-abbreviation] Asian Pac. J. Cancer Prev.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Thailand

[Chemical-registry-number] 0 / AR protein, human; 0 / Androgen Receptor Antagonists; 0 / Angiogenesis Inhibitors; 0 / Anticarcinogenic Agents; 0 / RNA, Messenger; 0 / Receptors, Androgen; 0 / Stilbenes; 0 / Ubiquitin; 0 / trypsin-like serine protease; 3XMK78S47O / Testosterone; 4TI98Z838E / Estradiol; EC 3.4.21.- / Serine Endopeptidases; Q369O8926L / resveratrol

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Effect of spinal cord injury upon prostate: adenocarcinoma of prostate in a spinal cord injury patient - a case report.

INTRODUCTION: Following spinal cord injury, prostate undergoes atrophy probably due to interruption of neuro-hormonal pathways.

The incidence of carcinoma of prostate is lower in patients with spinal cord injury above T-10 than in those with lesion below T-10.

In May 1995, routine blood test showed prostate-specific antigen to be 17.7 mg/ml.

Prostate biopsy revealed moderately differentiated primary adenocarcinoma of prostate; Gleason score was 3+3.

MRI of pelvis revealed no evidence of spread beyond prostatic capsule.

CONCLUSION: Although prostate gland undergoes atrophy in men who sustained spinal cord injury in early age, physicians should be vigilant and look for prostatic diseases particularly in men, who have sustained spinal cord injury during later period of life.

Therefore, it may be advisable to consider chemoprevention of prostate cancer with Finasteride, especially in men, who sustained cervical and upper dorsal spinal cord injury during later part of their life.

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[Cites] J Urol. 2009 Aug;182(2):499-507; discussion 508 [19524966.001]

[Cites] Can Urol Assoc J. 2009 Jun;3(3 Suppl 2):S115-20 [19543430.001]

[Cites] Urology. 2009 May;73(5):935-9 [19328538.001]

[Cites] Scand J Urol Nephrol. 2007;41(2):120-3 [17454950.001]

[Cites] J Spinal Cord Med. 2001 Summer;24(2):92-4; discussion 95 [11587425.001]

[Cites] J Urol. 1997 Jan;157(1):195-8 [8976249.001]

[Cites] Arch Intern Med. 1995 Feb 27;155(4):389-92 [7531426.001]

[Cites] J Am Paraplegia Soc. 1994 Jul;17(3):148-9 [7964711.001]

[Cites] Spinal Cord. 2006 Jan;44(1):24-7 [16010271.001]

(PMID = 20062548.001).

[ISSN] 1757-1626

[Journal-full-title] Cases journal

[ISO-abbreviation] Cases J

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2804017

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Salvage brachytherapy for local recurrences of prostate cancer treated previously with radiotherapy.

PURPOSE: The aim of the study was to analyze early effects and toxicity of salvage high dose rate brachytherapy for local recurrences of adenocarcinoma of the prostate after external beam radiotherapy (EBRT).

MATERIAL AND METHODS: In MCS Memorial Institute of Oncology in Gliwice a research programme on salvage HDR brachytherapy for local recurrences of prostate cancer treated previously with EBRT has been ongoing since February 2008.

CONCLUSIONS: Salvage brachytherapy for localized prostate cancer (3 × 10 Gy every 14 days) seems to be a safe and well tolerated procedure.

A significant decline in prostate-specific antigen (PSA) level is seen in patients with hormone-responsive cancer.

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(PMID = 28050174.001).

[ISSN] 1689-832X

[Journal-full-title] Journal of contemporary brachytherapy

[ISO-abbreviation] J Contemp Brachytherapy

[Language] eng

[Publication-type] Journal Article

[Publication-country] Poland

[Keywords] NOTNLM ; prostate cancer / radiotherapy / recurrences / salvage brachytherapy

   

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Combined radiotherapy and hormone therapy in non metastatic adenocarcinoma of prostate].

[Transliterated title] Hormonoradiothérapie des adénocarcinomes non métastatiques de la prostate.

Non metastatic adenocarcinoma of prostate can be cured in the vast majority of cases with surgery and/or external or interstitial radiotherapy.

Analysis of results of recent randomised trials comparing this association and exclusive radiotherapy allows for validating concept of combined radiotherapy and hormono therapy in locally advanced adenocarcinoma of prostate, while many questions should be more clearly answered.

[MeSH-major] Androgen Antagonists / therapeutic use. Prostatic Neoplasms / drug therapy. Prostatic Neoplasms / radiotherapy

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(PMID = 16396754.001).

[ISSN] 1769-6917

[Journal-full-title] Bulletin du cancer

[ISO-abbreviation] Bull Cancer

[Language] fre

[Publication-type] English Abstract; Journal Article

[Publication-country] France

[Chemical-registry-number] 0 / Androgen Antagonists; 0 / Antineoplastic Agents, Hormonal

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Cervical adenopathy presentation of adenocarcinoma of prostate].

[Transliterated title] Adenopatía cervical como presentación de adenocarcinoma de próstata.

The metastases of prostate cancer shows the regional lymphatic dissemination, being the cervical lymphatic metastases to infrequent and little reported in Literature.

When making biopsy of cervical adenopathy reported adenocarcinoma prostate metastases.

Within the diagnosis differential of the cervical adenopathys in neck in adult men it must consider the prostate carcinoma, because in an early diagnosis and adapting treatment it can prolong the survive.

[MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology

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(PMID = 18314662.001).

[ISSN] 0210-4806

[Journal-full-title] Actas urologicas españolas

[ISO-abbreviation] Actas Urol Esp

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Spain

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Bilateral testicular metastasis from prostatic adenocarcinoma mimicking an intertubular pattern of seminoma and expressing Rhamm.

Adenocarcinoma of prostate metastasizing to testis is a rare occurrence and is incidentally detected in orchiectomy specimens.

A rare case of bilateral testicular metastasis of prostatic adenocarcinoma is presented wherein the metastatic cells expressed CD168, a receptor for hyaluronan mediated motility (Rhamm), implicated in the development of androgen independence in prostate cancer.

[MeSH-major] Adenocarcinoma / secondary. Antigens, CD44 / biosynthesis. Extracellular Matrix Proteins / biosynthesis. Prostatic Neoplasms / pathology. Seminoma / pathology. Testicular Neoplasms / secondary

[MeSH-minor] Antineoplastic Agents, Hormonal / therapeutic use. Bone Neoplasms / secondary. Combined Modality Therapy. Diagnosis, Differential. Humans. Leuprolide / therapeutic use. Male. Middle Aged. Orchiectomy. Ultrasound, High-Intensity Focused, Transrectal

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(PMID = 20479558.001).

[ISSN] 1998-4138

[Journal-full-title] Journal of cancer research and therapeutics

[ISO-abbreviation] J Cancer Res Ther

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] India

[Chemical-registry-number] 0 / Antigens, CD44; 0 / Antineoplastic Agents, Hormonal; 0 / Extracellular Matrix Proteins; 0 / hyaluronan-mediated motility receptor; EFY6W0M8TG / Leuprolide

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pleural effusion as presentation of metastatic adenocarcinoma of prostate.

[MeSH-major] Adenocarcinoma / pathology. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Pleural Effusion, Malignant / etiology. Prostatic Neoplasms / pathology

[MeSH-minor] Aged. Humans. L-Lactate Dehydrogenase / metabolism. Male. Prostate-Specific Antigen / blood. Proteins / metabolism

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(PMID = 16218001.001).

[ISSN] 0038-4348

[Journal-full-title] Southern medical journal

[ISO-abbreviation] South. Med. J.

[Language] eng

[Publication-type] Case Reports; Letter

[Publication-country] United States

[Chemical-registry-number] 0 / Proteins; EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Combined radiotherapy and hormone therapy in non-metastatic adenocarcinoma of prostate].

[Transliterated title] Hormono-radiothérapie des adénocarcinomes non métastatiques de la prostate.

Non-metastatic adenocarcinoma of prostate can be cured in the vast majority of cases with surgery and/or external or interstitial radiotherapy.

Analysis of results of recent randomised trials comparing this association and exclusive radiotherapy allows for validating concept of combined radiotherapy and hormone therapy in locally advanced adenocarcinoma of prostate, while many questions should be more clearly answered.

[MeSH-major] Androgen Antagonists / therapeutic use. Neoplasms, Hormone-Dependent / drug therapy. Neoplasms, Hormone-Dependent / radiotherapy. Prostatic Neoplasms / drug therapy. Prostatic Neoplasms / radiotherapy

[MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Chemotherapy, Adjuvant. Combined Modality Therapy / methods. Gonadotropin-Releasing Hormone / analogs & derivatives. Humans. Male. Neoplasm Recurrence, Local / prevention & control. Prostate-Specific Antigen / blood

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(PMID = 19318304.001).

[ISSN] 1769-6917

[Journal-full-title] Bulletin du cancer

[ISO-abbreviation] Bull Cancer

[Language] fre

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] France

[Chemical-registry-number] 0 / Androgen Antagonists; 33515-09-2 / Gonadotropin-Releasing Hormone; EC 3.4.21.77 / Prostate-Specific Antigen

[Number-of-references] 40

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic adenocarcinoma of prostate in a healing sternotomy site.

Metastatic prostate cancer has a strong predilection for osseous sites, where the disease spreads in 80% of advanced cases.

The molecular mechanisms involved in prostate cancer establishment in bone are largely unknown; however, local tissue factors, including those involved in wound healing, have been suggested to play a critical role.

We present a case of tumor explosion in a median sternotomy wound after local prostate cancer therapy.

This case highlights that novel therapeutic interventions that disrupt the apparent synergistic relationship between tumor cells and the pro-tumorigenic microenvironment may hold great promise in constraining the proliferation of prostate cancer metastases.

[MeSH-major] Adenocarcinoma / secondary. Bone Neoplasms / secondary. Prostatic Neoplasms / pathology. Sternum / surgery. Wound Healing

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(PMID = 16808964.001).

[ISSN] 1527-9995

[Journal-full-title] Urology

[ISO-abbreviation] Urology

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Primary mucin-producing urothelial-type adenocarcinoma of prostate: report of 15 cases.

Prostatic urothelial-type adenocarcinoma arises through a process of glandular metaplasia of the prostatic urethral urothelium and subsequent in situ adenocarcinoma sometimes associated with villous adenoma.

These prostatic adenocarcinomas are analogous to nonurachal adenocarcinomas arising in the bladder from cystitis glandularis.

Only 2 cases of urothelial-type adenocarcinoma from an institution other than our own have been previously described.

The distinction between adenocarcinoma from another organ secondarily involving the prostate, usual adenocarcinoma of the prostate, and prostatic urothelial-type adenocarcinoma can present a significant diagnostic challenge and has significant therapeutic implications.

Fifteen cases of prostatic urothelial-type adenocarcinoma were retrieved from the consult files of one of the authors.

Mean patient age at diagnosis was 72 years (range 58 to 93 y).

In 8/15 (53%) cases, glandular metaplasia of the prostatic urethra and contiguous transition to adenocarcinoma were identified.

Immunohistochemical stains were negative for prostate specific antigen, prostate specific acid phosphatase, CDX2, and beta-catenin in all cases.

Prostatic urothelial-type adenocarcinoma is a rare aggressive cancer arising in the prostate.

The differential diagnosis includes conventional prostatic mucinous adenocarcinoma and secondary infiltration from a colonic or bladder adenocarcinoma.

Immunohistochemistry for prostate specific antigen, prostate specific acid phosphatase, and high molecular weight cytokeratin along with morphology can help rule out conventional prostate carcinoma. beta-catenin, CDX2, and clinical studies are needed to rule out colonic adenocarcinoma.

As prostatic urothelial-type adenocarcinoma is entirely analogous to bladder adenocarcinoma in both, its morphology and immunophenotype, only clinical studies or in some cases pathologic examination of the cystoprostatectomy specimen can exclude infiltration from a primary bladder adenocarcinoma.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma, Mucinous / diagnosis. Mucins / analysis. Prostatic Neoplasms / diagnosis. Urothelium / pathology

[MeSH-minor] Acid Phosphatase. Aged. Aged, 80 and over. Cell Differentiation. Diagnosis, Differential. Follow-Up Studies. Homeodomain Proteins / analysis. Humans. Immunohistochemistry. Keratin-20 / analysis. Keratin-7 / analysis. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Prostate-Specific Antigen / analysis. Protein Tyrosine Phosphatases / analysis. Time Factors. beta Catenin / analysis

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(PMID = 17721186.001).

[ISSN] 0147-5185

[Journal-full-title] The American journal of surgical pathology

[ISO-abbreviation] Am. J. Surg. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / CDX2 protein, human; 0 / CTNNB1 protein, human; 0 / Homeodomain Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / Mucins; 0 / beta Catenin; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

: e14575 Background: Tumoral Gastrin-releasing peptide (GRP) receptors are potential targets for diagnosis and therapy using radiolabeled or cytotoxic GRP analogs.

GRP-receptor overexpression has been detected in cancer cells and, more recently, also in the vascular bed of selected tumors.

More information on vascular GRP-receptors in cancer is required to asses their potential for vascular targeting applications.

METHODS: Frequent human cancers from the breast (n=134), lung (n=57), prostate (n=50), kidney (n=32), colon (n=46), urinary tract (n=26) and biliary tract (n=23) were analyzed using in vitro GRP-receptor autoradiography on tissue sections with the ¹²⁵I-[Tyr⁴]-bombesin radioligand and/or the universal radioligand ¹²⁵I-[D-Tyr⁶, ß-Ala¹¹, Phe¹³, Nle¹⁴]-bombesin(6-14).

RESULTS: Prevalence of vascular GRP-receptors is variable, ranging from 13% (prostate cancer) to 92% (urinary tract cancer).

Different tumor-types within a given site may have divergent prevalence of vascular GRP-receptors (e.g. lung: small cell cancer: 0%; adenocarcinoma: 59%; squamous carcinoma: 83%).

Also the vascular score varies widely, with highest score in urinary tract cancer (1.69), moderate scores in lung (0.91), colon (0.88), kidney (0.84) and biliary tract (0.69) cancers and low scores in breast (0.39) and prostate (0.14) cancers.

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(PMID = 27963648.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Inhibitor of differentiation-1 (Id1) characterization in poor-prognosis (PP) human bladder cancer (BCa) primary tumors and matched metastases (MTS) using a new monoclonal antibody (MoAb).

: e16119 Background: Id1, involved in cell differentiation, proliferation, tumor angiogenesis and metastasis, has recently showed to mediate lung MTS from breast cancer (PNAS 2007).

The expression of Id1 in human cancer has been related to poor prognosis breast, prostate (Gil-Bazo, Amer Soc Clin Oncol GU.

2009) and other non-adenocarcinoma tumors.

CONCLUSIONS: For the first time using a MoAb against Id1 and in accord with our previous observations in prostate cancer the selection of PP pts increases tumor cell Id1 exp. from 28 up to 80%.

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(PMID = 27963310.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Race and survival following brachytherapy-based treatment for men with localized or locally advanced adenocarcinoma of the prostate.

: 5068 Purpose: We investigated whether race was associated with risk of death following brachytherapy-based treatment for localized prostate cancer.

METHODS: The study cohort was comprised of 4,880 men with clinical stage T1-3N0M0 prostate cancer and minimum follow-up of 2 years who underwent brachytherapy-based treatment at 20 centers within the 21st Century Oncology consortium.

CONCLUSIONS: African-American and Hispanic race as compared to white race appear to confer a higher risk of mortality following brachytherapy-based treatment in men with localized or locally advanced prostate cancer.

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(PMID = 27964249.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

Twenty-seven pts (30%) had breast cancer, pathology followed by primary unknown tumours (21%), rabdomiosarcoma (10%), prostate adenocarcinoma (10%), gastric carcinoma (7%) and others (22%).

Forty-three pts received chemotherapy following the diagnosis of medullar infiltration, and normal leukocyte count was being seen in 40% of them after such treatment.

Nine episodes of febrile neutropenia were found; median overall survival (OS) following the diagnosis of neoplasia and myelophtisis were 13.8 months and 2.2 months respectively.

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(PMID = 27961689.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Microvesicular-mediated gene transfer of prostate tumor markers.

Recent work has focused on the potential for cancer vaccines via microvesicles.

Our objective is to determine whether there is transfer of genetic or transcriptional factors via microvesicles from human prostate cancer cells to fresh human marrow cells.

METHODS: Fresh prostate tissue was harvested from surgical specimens following radical retropubic prostatectomy.

Samples were histologically confirmed to contain prostatic adenocarcinoma.

Co-cultures were established using a transwell system in which 0.05-0.100 grams of prostate tissue was minced and co-cultured with 1-3 million normal, human donor marrow cells for 2-7 days.

Target cells were collected and total RNA was analyzed for prostate-specific gene expression byReal Time RT-PCR.

RESULTS: We have observed significant increases in gene expression in marrow cells co-cultured with prostate tumor cells (Gleason grades 6-9).

CONCLUSIONS: These studies demonstrate that prostate specific genes are present in fresh human marrow cells after co-culture with tumor tissue.

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(PMID = 27963050.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Identification and characterization of SP cells in human lung adenocarcinoma SPC-A1 cells.

With an extensive understanding of their biology, a major role for stem cells in the malignant process has been proposed and the existence of cancer stem cells(CSCs) has been confirmed in hematopoietic malignancies, brain cancer, and solid organ malignancies including breast, prostate, colon, and pancreatic cancer.

Lung cancer is the leading cause of cancer mortality in most large cities of China.

It is possible that lung cancer contains cancer stem cells responsible for its malignancy.

The aim of this study is to identify, characterize and enrich the CSC population that drives and maintains lung adenocarcinoma growth and metastasis.

METHODS: Side population (SP) cell analysis and sorting were applied to established human lung adenocarcinoma cell line and an attempt to further enrich them by preliminary serum-free culture before fluorescence activated cell sorting(FACS) was done.

RESULTS: Lung cancer cells could grow in a serum-free Medium (SFM) as non-adherent spheres similar to neurospheres or mammospheres.

Flow cytometric analysis of cell phenotyping showed that SP cells expressed CD133 and CD44, the common cell surface markers of cancer stem cells, while non-SP cells only expressed CD44.

CONCLUSIONS: SP cells existed in human lung adenocarcinoma cell lines and they could be further enriched by preliminary serum-free culture before FACS sorting.

SP cells possessed the properties of cancer stem cells.

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(PMID = 27964107.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Characterizing the clinical relevance of an embryonic stem cell phenotype in lung adenocarcinoma.

: 11001 Background: Cancer cells possess traits reminiscent of those ascribed to normal stem cells.

It is unclear whether these phenotypic similarities between normal/embryonic stem cells and mature tumor cells, specific to lung cancer, are a result of underlying biologic processes, such as specific molecular pathways and regulatory networks.

METHODS: Using a large cohort of lung cancer cell lines with associated gene expression data, genes associated with an embryonic stem cell identity were used to develop a 'signature' representative of embryonic stemness (ES) activity specific to lung adenocarcinoma.

The ES signature was applied to three independent early (stage I - IIIa) lung adenocarcinoma data sets (N = 634) with clinically annotated gene expression data.

RESULTS: Using Bayesian regression analysis, a 100 gene signature representative of ES activity in lung adenocarcinoma was developed and validated in a leave-one-out-analysis.

GSEA identified gene sets significantly represented in the ES signature: signature of neoplastic transformation, signature of undifferentiated cancer, BRCA pathway, and fibroblast serum response pathway, all associated with cancer invasiveness.

The ES signature was not prognostic in prostate, ovarian, or breast adenocarcinomas.

Lung tumors (N=634) and adenocarcinoma cell lines (N=31) with ES were more resistant to cisplatin (p<0.0001 and p=0.0063, respectively).

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(PMID = 27964049.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Effect of 25 hydroxy vitamin D status on serological response to influenza vaccine in cancer patients.

We conducted a prospective influenza vaccination study to determine the influence of vitamin D status on serological response to flu vaccine in cancer patients.

METHODS: Cancer patients at Roswell Park Cancer Institute were offered trivalent (H1N1, H3N2, B/Malaysia) Flu vaccine (Fluzone, 2006-7) and sera collected for hemagglutination inhibition (HI) assay titers.

Logistic regression model was used using other covariates such as age, gender, cancer type, and chemotherapy (CT) as controls.

RESULTS: 85 patients with colorectal, 35 with prostate, 1 with anal and 1 with gastric adenocarcinoma participated in the study.

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(PMID = 27961109.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Bortezomib as brief neoadjuvant therapy for localized high-risk prostate cancer (PCa) followed by radical prostatectomy (RP).

Histological evidence of adenocarcinoma of the prostate was required with clinical stage T_1c or T_2a with Gleason 8-10 disease, or clinical stage T_2b-T_2c with Gleason grade 7 and PSA of >10 ng/mL, or clinical stage T₃.

Upregulation of apoptosis, proliferation and phosphorylated (p)-Akt have been previously reported in a subset of patients by our group (Ayala GE et al, Clin Cancer Res. 2008;14:7511-8).

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(PMID = 27964403.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic role of somatostatin receptor subtypes in human prostate cancer.

: e16120 Background: Neuroendocrine differentiation (NED) in prostate carcinoma (PC) is frequently detected by immunohistochemistry as single cells in conventional adenocarcinoma.

The absence of SSTR 1 and 5 in more aggressive disease could represent a growth advantage in NED prostate cancer.

SSTRs and somatostatin analogs are potential targets for prostate cancer treatment.

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(PMID = 27963398.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Comparability of health-related quality of life (HRQOL), treatment decision making, and treatment satisfaction after PSA recurrence among prostate cancer patients who receive hormone therapy (HT) versus observation (OBS): Results from the COMPARE registry.

METHODS: The Comprehensive Multicenter Prostate Adenocarcinoma Registry (COMPARE) is an observational registry of men with PSA failure.

The median time between cancer diagnosis and registry enrollment was 6 years.

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(PMID = 27964431.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prostate cancer following testosterone replacement in Klinefelter syndrome.

However, it may remove the relative protection from adenocarcinoma of prostate, which is otherwise rare in uncomplicated Klinefelter syndrome.

We report the case of a 55-year-old man with Klinefelter syndrome who developed prostate cancer after only 7 years of androgen supplementation.

We recommend that serum prostate specific antigen (PSA) and digital rectal examinations be carried out during, as well as before androgen replacement.

[MeSH-major] Erectile Dysfunction / drug therapy. Hormone Replacement Therapy. Hormones / therapeutic use. Klinefelter Syndrome / complications. Prostatic Neoplasms / chemically induced. Testosterone / therapeutic use

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(PMID = 17295832.001).

[ISSN] 1445-1433

[Journal-full-title] ANZ journal of surgery

[ISO-abbreviation] ANZ J Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Australia

[Chemical-registry-number] 0 / Hormones; 3XMK78S47O / Testosterone

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [A case of giant prostate carcinoma difficult to diagnose because of absence of urinary difficulty].

The computed tomography revealed a giant pelvic mass with a high value of prostate specific antigen.

A transrectal prostatic biopsy was performed and the histopathological diagnosis was poorly differentiated adenocarcinoma of prostate.

[MeSH-major] Adenocarcinoma / diagnosis. Prostatic Neoplasms / diagnosis

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(PMID = 20048563.001).

[ISSN] 0018-1994

[Journal-full-title] Hinyokika kiyo. Acta urologica Japonica

[ISO-abbreviation] Hinyokika Kiyo

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Characteristics of morphological change in erythrocytes during metaststic adenocarcinoma of the prostate before and after castration.

For the experimental research we used a blood serum and erythrocytes of 15 men with metastasized adenocarcinoma before castration and a blood serum and erythrocytes of 15 men in 6 months after castration, also a blood serum and erythrocytes of practically healthy men.

Deep morphological changes of erythrocytes were observed in peripheral blood during metastasized adenocarcinoma of prostate gland before and after castration.

[MeSH-major] Adenocarcinoma / blood. Erythrocytes / pathology. Prostatic Neoplasms / blood

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(PMID = 19644180.001).

[ISSN] 1512-0112

[Journal-full-title] Georgian medical news

[ISO-abbreviation] Georgian Med News

[Language] eng

[Publication-type] Journal Article

[Publication-country] Georgia (Republic)

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Dynamics of the structural and electrical characteristics of erythrocytes in men with metastatic adenocarcinoma of the prostate before and after plastic orchiectomy.

The changes of electrophoretic mobility of erythrocytes in the practically healthy men and in men with metastatic prostate cancer before and after castration were studied.

Investigation revealed, that the level of electrophoretic mobility of erythrocytes was decreased in the blood of metastatic prostate cancer patients (before castration), as compared with control group and with post operational period data.

It was found, that during the malignant adenocarcinoma of prostate (before and after surgery) pathological changes in organism effect erythrocytes superficial membranes and alter their electrical and structural parameters.

Probably, that is one of the reasons of considerable decrease of erythrocytes electrophoretic mobility in patients with metastatic prostate adenocarcinoma (before castration).

[MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Erythrocytes / metabolism. Erythrocytes / ultrastructure. Orchiectomy / methods. Postoperative Care. Preoperative Care. Prostatic Neoplasms / secondary. Prostatic Neoplasms / surgery

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(PMID = 18250488.001).

[ISSN] 1512-0112

[Journal-full-title] Georgian medical news

[ISO-abbreviation] Georgian Med News

[Language] eng

[Publication-type] Journal Article

[Publication-country] Georgia (Republic)

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Giant prostate carcinoma treated effectively with endocrine therapy: case report].

Computed tomography (CT) and magnetic resonance imaging revealed a giant prostate tumor.

The histologic diagnosis was moderately differentiated adenocarcinoma of prostate.

Four months later, CT showed that the tumor had decreased markedly in size, and the serum prostate specific antigen level was within normal range.

Hormone refractory prostate cancer was not found 1 year after the start of treatment.

[MeSH-major] Adenocarcinoma / drug therapy. Androgen Antagonists / therapeutic use. Antineoplastic Agents, Hormonal / therapeutic use. Chlormadinone Acetate / therapeutic use. Goserelin / therapeutic use. Prostatic Neoplasms / drug therapy

[MeSH-minor] Adrenergic alpha-Antagonists / administration & dosage. Aged, 80 and over. Anilides / therapeutic use. Drug Administration Schedule. Drug Therapy, Combination. Humans. Magnetic Resonance Imaging. Male. Naphthalenes / administration & dosage. Nitriles. Piperazines / administration & dosage. Prostate-Specific Antigen / blood. Tosyl Compounds / therapeutic use

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(PMID = 17352166.001).

[ISSN] 0018-1994

[Journal-full-title] Hinyokika kiyo. Acta urologica Japonica

[ISO-abbreviation] Hinyokika Kiyo

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Adrenergic alpha-Antagonists; 0 / Androgen Antagonists; 0 / Anilides; 0 / Antineoplastic Agents, Hormonal; 0 / Naphthalenes; 0 / Nitriles; 0 / Piperazines; 0 / Tosyl Compounds; 0F65R8P09N / Goserelin; 0SY050L61N / Chlormadinone Acetate; A0Z3NAU9DP / bicalutamide; EC 3.4.21.77 / Prostate-Specific Antigen; R9PHW59SFN / naftopidil

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Initial Diagnosis of Mediastinal Lymph Node Metastases From Prostate Cancer by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration.

Endobronchial ultrasound-guided transbronchial needle aspiration was performed; cytology revealed adenocarcinoma, whereas histology contained adenocarcinoma of prostate origin.

Immunohistochemistry was strongly positive for prostate-specific antigen and prostate-specific acid phosphate for confirmation of metastases from the prostate cancer and negative for thyroid transcription factor-1.

Hence, the patient was diagnosed as having lymph node metastasis from a prostate cancer.

After the initial diagnosis, needle biopsy of the prostate was performed, and prostate cancer was confirmed.

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(PMID = 23168473.001).

[ISSN] 1944-6586

[Journal-full-title] Journal of bronchology & interventional pulmonology

[ISO-abbreviation] J Bronchology Interv Pulmonol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pretreatment total testosterone levels in patients with prostate cancer in the past two decades in Japan.

We studied the association of pretreatment total testosterone levels with the clinical stage and histological grade of prostate cancer.

Patients with poorly differentiated adenocarcinoma had significantly lower testosterone levels than those with the others (versus well; p<0.01, moderately; p<0.01).

CONCLUSIONS: Newly diagnosed patients with poorly differentiated adenocarcinoma of prostate have lower testosterone levels than the others.

[MeSH-major] Adenocarcinoma / blood. Prostatic Neoplasms / blood. Testosterone / blood

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(PMID = 17418977.001).

[ISSN] 0361-090X

[Journal-full-title] Cancer detection and prevention

[ISO-abbreviation] Cancer Detect. Prev.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 3XMK78S47O / Testosterone

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [A case of an asynchronic triple tumorous disorder: a rectal adenocarcinoma, a carcinoma of the kidney and a prostatic adenocarcinoma--case report].

[Transliterated title] Asynchronní triplicitní výskyt nádorového onemocnĕní: adenokarcinomu rekta, karcinomu ledviny a adenokarcinomu prostaty--kazuistika.

In the year 1980 in 56 years old patient had histologically proven rectal adenocarcinoma and consequently was done radical Miles amputation of rectum.

In December 1991 in the same patient was histologically proven well differentiated adenocarcinoma of prostate after transurethral resection of prostate.

Prostate cancer was threated bilateral orchiectomy (March 1992) and consequently from April to June 1992 was done small-volume irradiation of pelvic by Betatron X-ray, box technique with dosage 70 Gy.

Patient was died of generalisation renal cancer in the February 1998.

The carcinoma of prostate and rectum wasn't found in the autopsy.

[MeSH-major] Adenocarcinoma. Carcinoma, Renal Cell. Kidney Neoplasms. Neoplasms, Second Primary. Prostatic Neoplasms. Rectal Neoplasms

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(PMID = 15813456.001).

[ISSN] 0035-9351

[Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti

[ISO-abbreviation] Rozhl Chir

[Language] cze

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Czech Republic

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prostate specific antigen ratio: for diagnosis and assessment of aggressiveness of malignancy of prostate.

The search for a perfect tumour marker, which would be able to distinguish benign from malignant enlargement of prostate accurately, is still not complete.

Total Prostate Specific Antigen (TPSA), a good test, has it's own inadequacies but Free Prostate Specific Antigen (FPSA) to TPSA ratio is emerging as a better adjuvant to it.

This prospective study was done to verify the utility of FPSA to TPSA ratio in diagnosis of malignancy of prostate and its relationship to Gleason grading (indicating the aggressiveness) of adenocarcinoma of prostate.

100 patients with urinary symptoms, who were above fifty years of age and had prostatic enlargement, formed the study group.

Prostatic biopsy of all the cases was obtained and diagnostic histopathology and Gleason grading (in cases where adenocarcinoma was diagnosed) was done.

Thus making it very obvious that FPSA to TPSA ratio is an excellent adjuvant to TPSA for diagnosis of malignancy of prostate increasing the specificity and predictive value for positive test.

An inverse correlation (correlation coefficient = -0.95) was also found between PSA ratio and aggressiveness of prostate cancer, pointing towards its capability to predict the histological (Gleason) grade of the tumour.

[MeSH-major] Prostate-Specific Antigen / blood. Prostatic Neoplasms / blood

[MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Aged. Aged, 80 and over. Humans. Male. Middle Aged. Prospective Studies

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[ErratumIn] Indian J Pathol Microbiol. 2006 Jul;49(3):476

(PMID = 16933710.001).

[ISSN] 0377-4929

[Journal-full-title] Indian journal of pathology & microbiology

[ISO-abbreviation] Indian J Pathol Microbiol

[Language] eng

[Publication-type] Journal Article

[Publication-country] India

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Suppression of prostate cancer in a transgenic rat model via gamma-tocopherol activation of caspase signaling.

BACKGROUND: Epidemiological data indicate that intake of one form of vitamin E, gamma-tocopherol, may reduce prostate cancer risk, and several in vitro studies have demonstrated that gamma-tocopherol can inhibit prostate cancer cell growth.

The purpose of the present study was to confirm effects of gamma-tocopherol on prostate cancer in the transgenic rat for adenocarcinoma of prostate (TRAP) model established in our laboratory.

However, quantitative evaluation of prostatic lesions demonstrated significantly suppression of sequential progression from PIN to adenocarcinoma in a dose-dependent manner, along with clear activation of caspases 3 and 7 in the ventral lobe in both experiments.

CONCLUSIONS: The present study clearly demonstrated that gamma-tocopherol suppresses prostate tumor progression in an in vivo TRAP model, and could be a candidate chemopreventive agent for human prostate cancer.

[MeSH-major] Adenocarcinoma / prevention & control. Prostatic Neoplasms / prevention & control. gamma-Tocopherol / therapeutic use

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[Copyright] (c) 2009 Wiley-Liss, Inc.

(PMID = 19143023.001).

[ISSN] 1097-0045

[Journal-full-title] The Prostate

[ISO-abbreviation] Prostate

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antioxidants; 0 / Ceramides; 0 / Isoenzymes; 1406-66-2 / Tocopherols; 8EF1Z1238F / gamma-Tocopherol; EC 3.1.3.- / tartrate-resistant acid phosphatase; EC 3.1.3.2 / Acid Phosphatase

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

AVI-4126, a PMO targeted against c-MYC, has been extensively characterized in multiple cancer and other disease models and is currently in human clinical trials.

A phase I clinical study was conducted to address the issue of PMO bioavailability in malignant tumors surgically excised from patients with adenocarcinoma of prostate and breast 1 day after i.v. administration of a single dose of 90 mg AVI-4126 PMO.

Significant concentrations of intact PMO similar to the animal models were detected in both human prostate and breast tumor tissues with increased distribution in the tumor core for the vascular breast tumors.

No serious adverse events (graded according to National Cancer Institute Common Toxicity Criteria) were reported.

These studies show PMO bioavailability in tumor tissue and establish the feasibility of using PMO targeting specific genes in human cancer clinical trials.

[MeSH-major] Breast Neoplasms / drug therapy. Morpholines / adverse effects. Morpholines / pharmacokinetics. Prostatic Neoplasms / drug therapy

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(PMID = 15897595.001).

[ISSN] 1078-0432

[Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research

[ISO-abbreviation] Clin. Cancer Res.

[Language] eng

[Publication-type] Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Morpholines; 0 / Morpholinos

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Laparo-endoscopic single site (LESS) robotic radical prostatectomy in an Asian man with prostate cancer: an initial case report.

MATERIAL AND METHOD: A 71 year-old man with adenocarcinoma of prostate presented at Faculty of Medicine Siriraj Hospital, Bangkok.

Prostate-specific antigen level was 16.5 ng/ml and digital rectal examination approximately showed 30 gram prostate with nodule in both lobes.

[MeSH-major] Laparoscopy / methods. Prostatectomy / methods. Prostatic Neoplasms / surgery. Robotics

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(PMID = 20420116.001).

[ISSN] 0125-2208

[Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet

[ISO-abbreviation] J Med Assoc Thai

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Thailand

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Laparoscopic pelvic lymph node dissection-- method for prostate cancer staging].

INTRODUCTION: Laparoscopic pelvic lymph node dissection is recently widely used method for surgical staging for prostate cancer.

MATERIALS AND METHODS: Between April 2003 and December 2006 in our Clinic have been operated 20 patients with adenocarcinoma of prostate.

Median prostate specific antigen was 53.7 ng/ml.

Clinical methods - digital rectal examination of prostate, transrectal ultrasound punction biopsy of prostate, level of hemoglobin in blood to evaluate the blood loss.

This method is a useful for minimally invasive staging of prostate cancer.

[MeSH-major] Laparoscopy / methods. Lymph Node Excision. Lymph Nodes. Prostatic Neoplasms / pathology

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(PMID = 18622375.001).

[ISSN] 0450-2167

[Journal-full-title] Khirurgii︠a︡

[ISO-abbreviation] Khirurgiia (Sofiia)

[Language] bul

[Publication-type] English Abstract; Journal Article

[Publication-country] Bulgaria

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Mucin-producing urothelial-type adenocarcinoma of prostate: report of two cases of a rare and diagnostically challenging entity.

The differential diagnosis of mucin-producing adenocarcinoma of the prostate includes conventional prostatic adenocarcinoma with mucin production, secondary adenocarcinoma usually of colorectal origin and, very rarely, urothelial-type adenocarcinoma arising from either the prostatic urethra or proximal ducts.

Conventional prostatic adenocarcinoma with mucin production is readily identified by routine microscopy and immunohistochemistry.

The distinction between secondary adenocarcinoma and urothelial-type adenocarcinoma, however, can present a significant diagnostic challenge.

In addition, documented examples of the latter in the prostate are exceptionally rare.

A transurethral resection of prostate specimen and prostatic needle biopsies from two patients showing urothelial-type adenocarcinoma of the prostate were identified in our consultation files.

Transurethral resection of prostate material from two patients with clinically confirmed secondary adenocarcinoma of colonic origin involving the prostate and a prostatectomy specimen with mucinous conventional prostatic adenocarcinoma were also identified for comparison purposes.

Formalin-fixed, paraffin-embedded sections were stained for prostate-specific antigen (PSA), prostatic acid phosphatase, carcinoembryonic antigen, cytokeratin 7, cytokeratin 20 and high molecular weight cytokeratin 34betaE12.

The urothelial-type adenocarcinoma cases were diffusely positive for cytokeratin 7 and focally positive for 34betaE12 and cytokeratin 20, consistent with an origin from the urothelium of the prostatic urethra or proximal prostatic ducts.

In contrast, the secondary adenocarcinoma of colonic origin cases were diffusely cytokeratin 20 positive and either negative or focally positive for cytokeratin 7 and negative for 34betaE12.

The mucinous conventional prostatic adenocarcinoma was positive for PSA and prostatic acid phosphatase and negative for cytokeratin 7, cytokeratin 20 and 34betaE12.

[MeSH-major] Adenocarcinoma, Mucinous / pathology. Prostatic Neoplasms / pathology

[MeSH-minor] Acid Phosphatase. Aged. Aged, 80 and over. Carcinoembryonic Antigen / analysis. Carcinoma, Transitional Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Intermediate Filament Proteins / analysis. Keratin-20. Keratin-7. Keratins / analysis. Male. Middle Aged. Prostate-Specific Antigen / analysis. Protein Tyrosine Phosphatases / analysis

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(PMID = 15778694.001).

[ISSN] 0893-3952

[Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

[ISO-abbreviation] Mod. Pathol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / CK-34 beta E12; 0 / Carcinoembryonic Antigen; 0 / Intermediate Filament Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 68238-35-7 / Keratins; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Neuroendocrine differentiation in adenocarcinoma of prostate during combined androgen blockade therapy: a case report].

Prostatic neuroendocrine (NE) carcinoma is a rare disease with a poor prognosis because of its rapid progression and the androgen-independent characteristic, for which no successful therapy is available presently.

We report a case of NE differentiated prostate cancer, which was diagnosed as adenocarcinoma initially and progressed with NE differentiation during the combined androgen blockade therapy.

[MeSH-major] Adenocarcinoma / pathology. Androgen Antagonists / therapeutic use. Carcinoma, Neuroendocrine / pathology. Cell Transformation, Neoplastic / pathology. Prostatic Neoplasms / pathology

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(PMID = 15732339.001).

[ISSN] 0018-1994

[Journal-full-title] Hinyokika kiyo. Acta urologica Japonica

[ISO-abbreviation] Hinyokika Kiyo

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Androgen Antagonists

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Sweet's syndrome (acute febrile neutrophilic dermatosis) associated with adenocarcinoma of prostate and transitional cell carcinoma of urinary bladder.

In the present report, we describe an 82-year-old male with SS in association with adenocarcinoma of the prostate and transitional cell carcinoma of the urinary bladder.

[MeSH-major] Adenocarcinoma / pathology. Carcinoma, Transitional Cell / pathology. Neoplasms, Multiple Primary / diagnosis. Prostatic Neoplasms / pathology. Sweet Syndrome / diagnosis. Urinary Bladder Neoplasms / pathology

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(PMID = 16164716.001).

[ISSN] 0926-9959

[Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV

[ISO-abbreviation] J Eur Acad Dermatol Venereol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Netherlands

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Radical prostatectomy and postoperative radiation in patients with adenocarcinoma of prostate of intermediate and high risk for recurrence.

METHODS: Eighty-five consecutive patients categorized as intermediate (17.5%) and high risk (82.5%) of failure after definitive therapy for carcinoma of prostate according to the National Comprehensive Cancer Network (NCCN) underwent RP between 1989 and 1997.

Cancer-specific mortality was 3.5%.

CONCLUSIONS: In the intermediate and high-risk groups of patients with nonpalpable prostate cancer, RP and adjuvant RT may provide a biochemical recurrence-free rate (bRFR) comparable to that reported in other series with RP alone on patients in the low-risk groups.

[MeSH-major] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Prostatectomy. Prostatic Neoplasms / radiotherapy. Prostatic Neoplasms / surgery. Treatment Outcome

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(PMID = 15787077.001).

[ISSN] 0004-1858

[Journal-full-title] The Journal of the Arkansas Medical Society

[ISO-abbreviation] J Ark Med Soc

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Improved biochemical relapse-free survival for patients with large/wide glands treated with prostate seed implantation for localized adenocarcinoma of prostate.

OBJECTIVES: To analyze whether prostate size affects biochemical relapse-free survival (bRFS).

All patients were treated with iodine-125 alone as the radiotherapeutic modality and had a minimum of four posttreatment prostate-specific antigen values.

The factors examined in the univariate and multivariate analyses predicting for bRFS included gland volume, patient age, initial prostate-specific antigen value, biopsy Gleason score, clinical stage, and postimplant dosimetric variables.

On separate multivariate analyses, only the pretreatment prostate width and volume significantly influenced bRFS favorably (P = 0.0069 and P = 0.0255, respectively).

No association was found between gland size/width and postimplant dosimetry.

[MeSH-major] Adenocarcinoma / blood. Biomarkers, Tumor / blood. Brachytherapy / instrumentation. Prostate / pathology. Prostate-Specific Antigen / blood. Prostatic Neoplasms / blood

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(PMID = 17169646.001).

[ISSN] 1527-9995

[Journal-full-title] Urology

[ISO-abbreviation] Urology

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Combined small-cell carcinoma/adenocarcinoma of prostate: report of two cases].

We report two cases of combined small-cell carcinoma (SCC) and adenocarcinoma of prostate.

Whole body computed tomography (CT) revealed prostatic swelling, pancreatic mass, para-aortic lymphadenopathies, and multiple lung nodules.

Elevation of tumor markers (prostate specific antigen [PSA, 1,760 ng/ml] and neuron-specific enolase [NSE, 88 ng/ml]) was noted.

Needle biopsy of the prostate demonstrated both SCC and adenocarcinoma.

The patient died three months after the diagnosis.

The symptom and elevated serum PSA (23.1 ng/ml) prompted prostatic needle biopsy, which demonstrated combined SCC/adenocarcinoma.

Treatment of combined SCC and adenocarcinoma of prostate poses a dilemma.

In Case 1, MAB was effective for adenocarcinoma but not for SCC.

Much remains to be elucidated to better manage combined SCC/adenocarcinoma of prostate.

[MeSH-major] Adenocarcinoma. Carcinoma, Small Cell. Neoplasms, Multiple Primary. Prostatic Neoplasms

[MeSH-minor] Aged. Androgen Antagonists / therapeutic use. Biomarkers, Tumor / blood. Fatal Outcome. Humans. Male. Phosphopyruvate Hydratase / blood. Prostate-Specific Antigen / blood. Treatment Outcome

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(PMID = 17702184.001).

[ISSN] 0018-1994

[Journal-full-title] Hinyokika kiyo. Acta urologica Japonica

[ISO-abbreviation] Hinyokika Kiyo

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Androgen Antagonists; 0 / Biomarkers, Tumor; EC 3.4.21.77 / Prostate-Specific Antigen; EC 4.2.1.11 / Phosphopyruvate Hydratase

   

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[Title] [Regression of a choroidal metastasis from prostate adenocarcinoma after hormonal therapy].

[Transliterated title] Regresión de una metástasis coroidea de adenocarcinoma de próstata con tratamiento hormonal.

CASE REPORT: We report a case of a patient diagnosed with prostatic adenocarcinoma with multiple bone metastases and a choroidal metastasis in his left eye.

DISCUSSION: Complete resolution of choroidal metastases of prostatic adenocarcinoma with hormonal therapy is exceptional, but the effect of this treatment on such metastases should be observed before recommending radiation therapy.

[MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Androgen Antagonists / therapeutic use. Anilides / therapeutic use. Antineoplastic Agents, Hormonal / therapeutic use. Choroid Neoplasms / secondary. Nitriles / therapeutic use. Prostatic Neoplasms / drug therapy. Tosyl Compounds / therapeutic use

[MeSH-minor] Aged. Biopsy. Bone Neoplasms / secondary. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Prostate / pathology. Prostate-Specific Antigen / blood. Time Factors. Treatment Outcome

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(PMID = 17979041.001).

[ISSN] 0365-6691

[Journal-full-title] Archivos de la Sociedad Española de Oftalmología

[ISO-abbreviation] Arch Soc Esp Oftalmol

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Spain

[Chemical-registry-number] 0 / Androgen Antagonists; 0 / Anilides; 0 / Antineoplastic Agents, Hormonal; 0 / Nitriles; 0 / Tosyl Compounds; A0Z3NAU9DP / bicalutamide; EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Xanthoma of the prostate: a mimicker of high-grade prostate adenocarcinoma.

Prostatic xanthoma may mimic high-grade prostatic adenocarcinoma or prostate cancer treated with hormone therapy.

From 1995 to 2006, 40 cases of prostatic xanthoma were diagnosed at The Johns Hopkins Hospital.

Xanthoma was found on needle biopsy in 25 cases, with 2 cases noted on transurethral resection of prostate.

Twenty-six cases contained only 1 focus of prostatic xanthoma with 1 case having 3 foci on the same core biopsy specimen.

Ten xanthomas consisted of cords and individual cells infiltrating the prostatic stroma, further mimicking high-grade prostate carcinoma.

One of 15 (6.7%), 2/17 (11.8%), and 1/12 (8.3%) cases were positive for prostate-specific antigen, prostate-specific acid phosphatase, and alpha-methylacyl-CoA racemase, respectively.

Careful attention to morphology with adjunctive use of CD68 and CAM5.2 immunohistochemical stains are helpful in the diagnosis of prostatic xanthoma, especially in difficult cases with an infiltrative pattern.

[MeSH-major] Adenocarcinoma / pathology. Prostate / pathology. Prostatic Neoplasms / pathology. Xanthomatosis / pathology

[MeSH-minor] Biomarkers / metabolism. Biopsy, Needle. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Male

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(PMID = 17667547.001).

[ISSN] 0147-5185

[Journal-full-title] The American journal of surgical pathology

[ISO-abbreviation] Am. J. Surg. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Choroidal metastasis from clinically regressed prostate adenocarcinoma: imaging of a rare case].

[Transliterated title] Métastase choroïdienne d'un adénocarcinome de la prostate: iconographie d'un cas rare.

We report a rare case of prostatic adenocarcinoma metastases at the choroids, diagnosed and followed by fluorescein angiography (FA), indocyanine-green angiography (ICGA), and optical coherence tomography (OCT-3 Stratus).

The systemic workup, including hematologic analysis and total-body computed tomography (CT), revealed elevated serum prostate-specific antigen (PSA) and alkaline phosphatase, extensive abnormalities of the axial skeleton, and nodular pulmonary shadows; therefore, prostatic adenocarcinoma was suspected.

Needle biopsies (prostatic and pulmonary) confirmed adenocarcinoma of the prostate, with metastatic disease.

DISCUSSION: Prostatic carcinoma should be considered in any male patient with a choroidal mass suspected of being a metastasis.

In our patient, FA, ICGA, and OCT clearly documented the complete regression of choroidal metastasis from prostatic carcinoma.

Fluorescein angiography, indocyanine-green angiography, and optical coherence tomography are useful tools in the diagnosis and follow-up of prostatic adenocarcinoma metastatic to the choroid.

[MeSH-major] Adenocarcinoma / secondary. Choroid Neoplasms / secondary. Prostatic Neoplasms / pathology

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(PMID = 19107059.001).

[ISSN] 1773-0597

[Journal-full-title] Journal français d'ophtalmologie

[ISO-abbreviation] J Fr Ophtalmol

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] France

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Expression of the cerbB-2 (HER-2/neu) oncoprotein in prostatic adenocarcinoma].

[Transliterated title] Estudio de la expresión de cerbB-2 en el adenocarcinoma de próstata.

OBJECTIVES: Our aim is to determine the expression of the cerbB-2 oncoprotein in prostate cancers using an immunohistochemistry staining and to compare these results with several clinical and histological prognostic factors.

METHODS: An immunohistochemical staining using the cerbB-2 monoclonal antibody (Dako) was performed in 32 radical prostatectomy specimens diagnosed of adenocarcinoma.

1) This study shows that 44% of all prostate cancer express the cerbB-2 oncoprotein with immunohistochemical technique.

2) These findings suggest that is necessary to standardize the immunohistochemical staining procedure with cerbB-2 in prostate adenocarcinoma.

[MeSH-major] Adenocarcinoma / metabolism. Prostatic Neoplasms / metabolism. Receptor, ErbB-2 / metabolism

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(PMID = 15786765.001).

[ISSN] 0210-4806

[Journal-full-title] Actas urologicas españolas

[ISO-abbreviation] Actas Urol Esp

[Language] spa

[Publication-type] Comparative Study; English Abstract; Journal Article

[Publication-country] Spain

[Chemical-registry-number] EC 2.7.10.1 / Receptor, ErbB-2

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Cytophotometric expression of tumor antigen markers Ki-67 and CD-34 in prostate adenocarcinoma].

[Transliterated title] Estudo citofotométrico da expressão dos marcadores tumorais Ki-67 e CD34 no adenocarcinoma de próstata.

OBJECTIVE: To quantify the percentage of immunostaining through the labeling index as well as the optical density of Ki-67 and CD34 in prostate adenocarcinoma and compare the results between markers.

METHODS: Markers Ki-67 and CD34 were studied using immunohistochemistry in 34 cases of prostate adenocarcinoma from radical prostatectomies performed at the Hospital Regional do Gama in Brasilia, Brazil from 2000 through 2005.

[MeSH-major] Adenocarcinoma / metabolism. Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Ki-67 Antigen / metabolism. Prostatic Neoplasms / metabolism

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(PMID = 20140393.001).

[ISSN] 1809-4546

[Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões

[ISO-abbreviation] Rev Col Bras Cir

[Language] por

[Publication-type] English Abstract; Journal Article

[Publication-country] Brazil

[Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Incidental finding of a meningioma-en-plaque in a patient with prostate adenocarcinoma].

[Transliterated title] Hallazgo incidental de un meningioma en placa en un paciente con adenocarcinoma de próstata.

We present a case of a large MEP, which was an incidental finding on a scintigraphy study of a patient with prostate adenocarcinoma, this finding being histologically confirmed.

[MeSH-major] Adenocarcinoma / radionuclide imaging. Incidental Findings. Meningeal Neoplasms / radionuclide imaging. Meningioma / radionuclide imaging. Neoplasms, Multiple Primary / radionuclide imaging. Prostatic Neoplasms / radionuclide imaging

[MeSH-minor] Aged. Craniocerebral Trauma / radionuclide imaging. Diagnosis, Differential. Diagnostic Errors. Exophthalmos / etiology. Headache / etiology. Humans. Magnetic Resonance Imaging. Male. Osteitis Deformans / radionuclide imaging. Radiopharmaceuticals. Skull Neoplasms / radionuclide imaging. Skull Neoplasms / secondary. Technetium Tc 99m Medronate. Tomography, X-Ray Computed

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[Copyright] Copyright © 2009 Elsevier España, S.L. y SEMNIM. All rights reserved.

(PMID = 20398966.001).

[ISSN] 0212-6982

[Journal-full-title] Revista española de medicina nuclear

[ISO-abbreviation] Rev Esp Med Nucl

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Spain

[Chemical-registry-number] 0 / Radiopharmaceuticals; X89XV46R07 / Technetium Tc 99m Medronate

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Watchful waiting in incidental adenocarcinoma of the prostate].

[Transliterated title] Actitud expectante en el adenocarcinoma incidental de próstata.

OBJECTIVE: To describe the outcome of patients diagnosed of incidental prostate adenocarcinoma managed by watchful waiting.

MATERIAL AND METHODS: We included patients with PSA< 4 ng/mL or higher with previous negative biopsy, who underwent surgery for BPH being diagnosed of incidental prostate adenocarcinoma.

We performed a descriptive and retrospective study in patients with this diagnosis between 1992 and 2007.

Progression variables were: age, preoperative and postoperative PSA, stage, Gleason score, prostate volume, initial treatment, PSA evolution and salvage treatment if necessary.

RESULTS: 47 patients were diagnosed of incidental prostatic adenocarcinoma, finding an incidence of 4.25%.

CONCLUSION: Watchful waiting is a useful option in patients with incidental prostate adenocarcinoma and favourable prognostic criteria.

[MeSH-major] Adenocarcinoma / therapy. Prostatic Neoplasms / therapy. Watchful Waiting

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(PMID = 21159280.001).

[ISSN] 1699-7980

[Journal-full-title] Actas urologicas españolas

[ISO-abbreviation] Actas Urol Esp

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Spain

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic value of DNA analysis of prostate adenocarcinoma: correlation to clinicopathologic predictors.

The ability to accurately predict tumor behavior and patient survival is a problem in managing patients with prostate cancer.

DNA ploidy provides important information for the evaluation of the prognosis of prostate cancer.

The aim of this study was to investigate the DNA ploidy in imprints from prostate adenocarcinomas in a group of 70 patients in relation to Gleason score, tumor differentiation, stage and PSA serum levels.

Our results conclude that DNA ploidy status appears to be an additional marker in the field of prognosis of prostatic adenocarcinoma and could provide useful information on the potential behavior of prostate cancer.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. DNA / metabolism. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / genetics

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(PMID = 16110761.001).

[ISSN] 0392-9078

[Journal-full-title] Journal of experimental & clinical cancer research : CR

[ISO-abbreviation] J. Exp. Clin. Cancer Res.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Italy

[Chemical-registry-number] 9007-49-2 / DNA

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic value of DNA ploidy, bcl-2 and p53 in localized prostate adenocarcinoma incidentally discovered at transurethral prostatectomy.

PURPOSE: Discovery of prostatic adenocarcinoma limited to transurethral resection material generates a treatment dilemma.

We investigated the usefulness of parameters shown to be associated with prognosis in prostate cancer (p53 and bcl-2 immuno-expression, DNA cell cycle analysis and Gleason score) to stratify these incidentally identified tumors to guide clinical decision making.

MATERIALS AND METHODS: Paraffin embedded tissues from transurethral prostate resection specimens containing T1a prostate adenocarcinoma from 44 patients who underwent resection between 1980 and 1990 were immunostained for p53 and bcl-2, and subjected to flow cytometry to determine DNA ploidy.

Statistical relationships among these 4 variables, tumor progression and cancer specific survival were analyzed.

RESULTS: Six of 44 patients in the study population had cancer progression.

Only 2 tumors studied were aneuploid and neither of these 2 patients had cancer progression.

Only Gleason score was a significant predictor of cancer progression on univariate and multivariate Cox regression analysis (p = 0.045 and 0.046, respectively).

CONCLUSIONS: For T1a prostate cancer incidentally detected on transurethral prostate resection p53 and bcl-2 immuno-expression, and DNA ploidy do not predict survival or disease progression.

[MeSH-major] Adenocarcinoma / genetics. Incidental Findings. Prostatectomy. Prostatic Neoplasms / genetics. Proto-Oncogene Proteins c-bcl-2 / metabolism

[MeSH-minor] Aged. Aged, 80 and over. Disease Progression. Flow Cytometry. Humans. Immunohistochemistry. Male. Middle Aged. Ploidies. Prognosis. Prostatic Diseases / surgery

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(PMID = 17085199.001).

[ISSN] 0022-5347

[Journal-full-title] The Journal of urology

[ISO-abbreviation] J. Urol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] BRAF and KRAS mutations in prostatic adenocarcinoma.

RAS mutations are known to occur in prostate adenocarcinomas, but little is known about BRAF mutations in these tumors.

In the present study, BRAF and KRAS mutations were characterized in 206 prostate adenocarcinomas by enhanced PCR-RFLP and direct sequencing.

Mutations in codon 600 of BRAF were identified in 21 (10.2%) of 206 prostate adenocarcinomas.

KRAS mutations in codons 12 or 13 were found in 15 (7.3%) of 206 prostate adenocarcinomas.

Prostate adenocarcinomas with a BRAF mutation tended to show higher preoperative serum PSA levels, Gleason scores and tumor stages than prostate adenocarcinomas with a KRAS mutation.

The results obtained show that BRAF mutations are as uncommon as KRAS mutations in prostate adenocarcinoma.

Although BRAF and KRAS are members of the same RAS/ERK signaling pathway, prostate adenocarcinomas with a BRAF mutation showed clinicopathologic features that differed from those of prostate adenocarcinoma with a KRAS mutation.

[MeSH-major] Adenocarcinoma / genetics. Oncogene Protein p21(ras) / genetics. Prostatic Neoplasms / genetics. Proto-Oncogene Proteins B-raf / genetics

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[Copyright] Copyright 2006 Wiley-Liss, Inc.

(PMID = 16721785.001).

[ISSN] 0020-7136

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / Oncogene Protein p21(ras)

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] p53 and p21/WAF-1 overexpressions in prostatic adenocarcinoma.

OBJECTIVES: This study was carried out to determine the role of p53 and p21 in the pathogenesis of prostatic adenocarcinoma and their association with tumour grade.

METHOD: Sixty-seven histologically confirmed prostatic adenocarcinoma cases collected from Hospital Universiti Kebangsaan Malaysia and General Hospital Kuala Lumpur were studied.

RESULTS: IHC positivity for p53 was expressed in 1/2 (50%) low grade, 14/33 (42%) intermediate grade, and 21/32 (66%) high grade tumours. p21 was expressed in 0/2 low grade, 16/33 (48%) intermediate grade and 15/32 (47%) high grade tumours. p53 and p21 expressions did not show statistically significant correlation with the different grades of prostatic adenocarcinoma or with each other (p = 0.42).

CONCLUSION: Although the p53 positivity rate was higher in high-grade prostate adenocarcinoma, this was not statistically significant.

[MeSH-major] Adenocarcinoma / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Prostatic Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism

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(PMID = 18376798.001).

[ISSN] 0126-8635

[Journal-full-title] The Malaysian journal of pathology

[ISO-abbreviation] Malays J Pathol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Malaysia

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Protein p53

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Epigenetic events, remodelling enzymes and their relationship to chromatin organization in prostatic intraepithelial neoplasia and prostatic adenocarcinoma.

OBJECTIVE: To explore the nuclear chromatin phenotype, overall epigenetic mechanisms, chromatin remodelling enzymes and their role as diagnostic biomarkers in prostate lesions, using high-resolution computerized quantitative digital image analysis (DIA).

MATERIALS AND METHODS: A tissue microarray (TMA) was constructed using paraffin wax-embedded prostatic tissues from 78 patients, containing 30 cores of benign prostatic hyperplasia (BPH), 10 of low-grade prostatic intraepithelial neoplasia (LGPIN), 38 of prostate adenocarcinoma, 20 of BPH tissue excised at 0.6-1 mm from LGPIN lesions, and 10 of BPH prostatic tissues obtained 0.6-1 mm from high-grade PIN (HGPIN) lesions.

In PIN lesions, there was a high chromatin content with DNA-hypermethylation, while in prostatic adenocarcinoma there was a lower chromatin content with DNA-hypomethylation and H3K9-hypoacetylation.

CONCLUSIONS: The present study confirms the ability of high-resolution computerized digital imaging of nuclear texture features to detect changes in chromatin phenotype, epigenetic events and the presence of chromatin remodelling, factors that can be used to distinguish between different prostatic pathologies, i.e.

BPH, LGPIN, HGPIN and prostate adenocarcinoma, and further allow the detection of MAC near PIN lesions.

Further studies are needed to elucidate the complex interplay between chromatin structure, its modifications and the progression of prostate cancer.

[MeSH-major] Adenocarcinoma / genetics. Chromatin. Prostatic Intraepithelial Neoplasia / genetics. Prostatic Neoplasms / genetics

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(PMID = 17378849.001).

[ISSN] 1464-4096

[Journal-full-title] BJU international

[ISO-abbreviation] BJU Int.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Chromatin

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Number and location of nucleoli and presence of apoptotic bodies in diagnostically challenging cases of prostate adenocarcinoma on needle biopsy.

There is limited published data regarding the significance of the number or position of nucleoli and the presence of apoptotic bodies in diagnostically challenging cases of adenocarcinoma of the prostate on needle biopsy material.

One hundred consecutive prostate cancers on needle biopsy were sent because of diagnostic difficulty to an expert in urological pathology, and the remaining normal benign prostatic glands on the same core were evaluated for the number and location of nucleoli and for the presence of mitotic figures and apoptotic bodies.

For comparison, the same parameters were evaluated in mimickers of cancer on needle biopsy from other cases, including partial atrophy (n = 135), fully developed atrophy (n = 89), adenosis (n = 50), prostate glands with acute inflammation (n = 50), and high-grade prostatic intraepithelial neoplasia (n = 100).

Although the number and position of nucleoli did not discriminate between cancer and benign mimickers, mitotic figures and apoptotic bodies were more commonly seen in cancer.

Apoptotic bodies in particular were seen fairly frequently (34%) in prostatic adenocarcinoma (also seen in 13% of high-grade prostatic intraepithelial neoplasia), yet rarely in benign mimickers on needle biopsy.

Our findings indicate that the presence of apoptotic bodies should be added to the list of histological features that are helpful in the diagnosis of challenging cases of prostate cancer on needle biopsy.

[MeSH-major] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Cell Nucleolus / pathology. Inclusion Bodies / pathology. Prostatic Neoplasms / pathology

[MeSH-minor] Apoptosis / physiology. Biopsy, Needle. Humans. Immunohistochemistry. Male. Prostatic Diseases / pathology

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(PMID = 16260270.001).

[ISSN] 0046-8177

[Journal-full-title] Human pathology

[ISO-abbreviation] Hum. Pathol.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Differential expression of steroid receptors in prostate tissues before and after radiation therapy for prostatic adenocarcinoma.

The expression, distribution and the role of steroid receptors in benign and malignant untreated prostate tissues is well recognized, however, the status of steroid receptors in prostate after radiotherapy (RT) for adenocarcinoma has not yet been studied fully.

Immunohistochemical evaluation of androgen receptor (AR), estrogen receptor-alpha (ER-alpha), estrogen receptor-beta (ER-beta), and progesterone receptor (PR) was carried out in prostate needle biopsies obtained before and after radiotherapy from 60 patients with adenocarcinoma.

The ER-beta transcripts were also studied by RT-PCR in LNCaP prostate carcinoma cell line before and 24 hr after gamma-irradiation at 0.5 Gy and 8.0 Gy.

Significantly higher level of ER-beta expression was found in post-radiation samples of prostate adenocarcinoma and benign epithelium.

After RT, all steroid receptors were upregulated in prostatic stroma.

Although a positive association between AR and ER-beta expression was observed in pre-treatment prostate adenocarcinoma, it was lost after RT suggesting that these 2 steroid receptors respond differently to RT.

Upregulation of all steroid receptors in the prostate stroma and upregulation of ER-beta in the tumor epithelium after RT, may represent a protective tissue response to radiation-induced tissue injury.

[MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / radiotherapy. Gene Expression Regulation, Neoplastic. Prostatic Neoplasms / genetics. Prostatic Neoplasms / radiotherapy. Receptors, Steroid / genetics

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[Copyright] (c) 2005 Wiley-Liss, Inc.

(PMID = 15900599.001).

[ISSN] 0020-7136

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Receptors, Steroid

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Distal seminal vesicle invasion by prostate adenocarcinoma does not occur in isolation of proximal seminal vesicle invasion or lymphovascular infiltration.

AIMS: Seminal vesicle (SV) invasion by prostatic adenocarcinoma is a poor prognostic indicator.

This study examines the distribution of invasive prostatic adenocarcinoma in SVs and makes recommendations regarding sampling procedures.

The site of invasive prostatic carcinoma within the muscular wall of the SV and its presence in the ejaculatory duct was recorded.

Patients ranged in age from 52 to 73 years (mean 64 years), with a serum prostatic specific antigen ranging from 3.7 to 46 ng/mL (mean 10.6 ng/mL).

All but one of the SV positive cases (98.2%) had involvement of the proximal third (15 right, 17 left and 23 both) of the gland, 35 of which (63.6%) had infiltration only of the proximal SV.

Lymphovascular invasion within the prostate was seen in 71.4% of cases.

[MeSH-major] Adenocarcinoma / pathology. Prostatic Neoplasms / pathology. Seminal Vesicles / pathology

[MeSH-minor] Aged. Digital Rectal Examination. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Prognosis. Prostate-Specific Antigen / blood. Prostatectomy

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(PMID = 20438404.001).

[ISSN] 1465-3931

[Journal-full-title] Pathology

[ISO-abbreviation] Pathology

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Brain metastases from prostate adenocarcinoma.

Brain metastases of prostate adenocarcinoma are rare.

We report a case of brain metastases from prostate adenocarcinoma 15 months after the diagnosis of the primary tumour.

The biopsy performed showed metastatic prostate adenocarcinoma.

[MeSH-major] Adenocarcinoma / secondary. Brain Neoplasms / secondary. Prostatic Neoplasms / pathology

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(PMID = 19155207.001).

[ISSN] 1699-048X

[Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

[ISO-abbreviation] Clin Transl Oncol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Spain

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Phenotypic characterization of the infiltrating immune cells in normal prostate, benign nodular prostatic hyperplasia and prostatic adenocarcinoma.

BACKGROUND: Immune cell infiltrate is a constant feature in normal prostate, benign nodular prostatic hyperplasia and prostatic adenocarcinoma.

This study elaborates on the cells of the immune system present in normal prostate, benign nodular prostatic hyperplasia and prostatic adenocarcinoma.

HYPOTHESIS: Here, we hypothesized that "the development of benign nodular prostatic hyperplasia and prostatic adenocarcinoma is associated with numeric alterations of the immune cell infiltrate".

MATERIALS AND METHODS: A total of 50 transurethral prostatic resection specimens, each entailing normal prostate, benign nodular prostatic hyperplasia and high grade prostatic adenocarcinoma were evaluated for the density and phenotype of the immune cells using immunohistological methods and mouse monoclonal antibodies decorating T cells (CD3), histiocytes (CD68) and B lymphocytes (CD20).

We observed variations in the density of the immune cells among the normal prostate, benign nodular prostatic hyperplasia and high grade prostatic adenocarcinoma.

Compared with normal prostate, benign nodular prostatic hyperplasia had a statistically significant high density of immune cells (3.4+/-0.4versus 13.5+/-1.0, P<0.00).

In contrast, a significant decrease in the counts of these cells was observed in high-grade prostatic adenocarcinoma compared to benign nodular prostatic hyperplasia (13.5+/-1.0 versus 5.2+/-0.3, P<0.01).

CONCLUSIONS: The increased density of immune cells (predominantly CD(+)3 T cells) in benign nodular prostatic hyperplasia suggests that the initial response to cellular damage is mediated by cell-mediated immunity.

The decreased density of immune cells in high-grade prostatic adenocarcinoma may reflect immunosuppression.

[MeSH-major] Cell Movement. Immune System / cytology. Prostate / pathology. Prostatic Hyperplasia / pathology. Prostatic Neoplasms / pathology

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(PMID = 19111537.001).

[ISSN] 1096-0945

[Journal-full-title] Experimental and molecular pathology

[ISO-abbreviation] Exp. Mol. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, CD

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Can telomere alterations predict biochemical recurrence in prostate adenocarcinoma? A preliminary study.

Telomere shortening can be one of the ways that cause chromosomal instability in the pathogenesis of prostatic carcinoma.

In the current study, we evaluated telomere length (TL) in normal and malignant prostate tissues, and its association with prognostic factors and with time to biochemical tumor recurrence.

The majority (49/61) of prostate cancers displayed abnormally short telomeres.

Telomere shortening is a common alteration in prostatic adenocarcinoma.

[MeSH-major] Adenocarcinoma / genetics. Prostatic Neoplasms / genetics. Telomere / metabolism

[MeSH-minor] Aged. Disease-Free Survival. Humans. In Situ Hybridization, Fluorescence. Kaplan-Meier Estimate. Logistic Models. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Pilot Projects. Proportional Hazards Models. Prostate-Specific Antigen / blood. Prostatectomy. Risk Assessment. Risk Factors. Time Factors. Tissue Array Analysis. Treatment Outcome

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[Copyright] Copyright © 2010 Elsevier GmbH. All rights reserved.

(PMID = 20674190.001).

[ISSN] 1618-0631

[Journal-full-title] Pathology, research and practice

[ISO-abbreviation] Pathol. Res. Pract.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Use of picosecond Kerr-gated Raman spectroscopy to suppress signals from both surface and deep layers in bladder and prostate tissue.

Prostate samples for this study were obtained by taking a chip at the transurethral resection of the prostate (TURP), and bladder samples from a biopsy taken at transurethral resection of bladder tumor (TURBT) and TURP.

Spectra obtained through the bladder and prostate gland tissue, at different time delays after the laser pulse, clearly show change in the spectra as depth profiling occurs, eventually showing signals from the uric acid cell and urea cell, respectively.

We show for the first time, using this novel technique, that we are able to obtain spectra from different depths through both the prostate gland and the bladder.

This has major implications in the future of Raman spectroscopy as a tool for diagnosis.

With the help of Raman spectroscopy and Kerr gating, it may be possible to pick up the spectral differences from a small focus of adenocarcinoma of the prostate gland in an otherwise benign gland, and also stage the bladder cancers by assessing the base of the tumor post resection.

[MeSH-major] Biomarkers, Tumor / analysis. Prostatic Neoplasms / chemistry. Prostatic Neoplasms / diagnosis. Spectrum Analysis, Raman / methods. Urinary Bladder Neoplasms / chemistry. Urinary Bladder Neoplasms / diagnosis

[MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / diagnosis. Algorithms. Artifacts. Humans. Male. Reproducibility of Results. Sensitivity and Specificity

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(PMID = 16178640.001).

[ISSN] 1083-3668

[Journal-full-title] Journal of biomedical optics

[ISO-abbreviation] J Biomed Opt

[Language] eng

[Publication-type] Clinical Trial; Comparative Study; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Prostate adenocarcinoma metastatic to penis].

[Transliterated title] Adenocarcinoma de próstata metastático a pene.

Prostate cancer is a disease that appears with a very high frequency.

We present one case of a patient with painless metastatic nodules on the penis secondary to a prostate cancer.

[MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Prostatic Neoplasms / pathology

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[CommentIn] Actas Urol Esp. 2006 Oct;30(9):962-4 [17175940.001]

(PMID = 17078582.001).

[ISSN] 0210-4806

[Journal-full-title] Actas urologicas españolas

[ISO-abbreviation] Actas Urol Esp

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article; Review

[Publication-country] Spain

[Number-of-references] 6

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Urothelial carcinoma and prostatic adenocarcinoma presenting as collision tumors.

Urothelial carcinoma (UC) and prostatic adenocarcinoma (PAC) commonly occur in elderly patients and share common carcinogenic factors that could be identified in the urine.

Simultaneous occurrence of PAC and UC in the prostate is not uncommon; however, urinary bladder location of both lesions has not yet been reported.

All patients were diagnosed with high grade PAC and either had simultaneous at the initial diagnosis or developed UC during the follow up for PAC.

In conclusion, awareness of this association is important in making the correct diagnosis, especially when dealing with urinary bladder biopsy material.

[MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary. Prostatic Neoplasms / diagnosis

[MeSH-minor] Aged, 80 and over. Biopsy. Combined Modality Therapy. Cystoscopy. Diagnosis, Differential. Fatal Outcome. Humans. Male

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(PMID = 19796465.001).

[ISSN] 1195-9479

[Journal-full-title] The Canadian journal of urology

[ISO-abbreviation] Can J Urol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Canada

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Dietary genistein improves survival and reduces expression of osteopontin in the prostate of transgenic mice with prostatic adenocarcinoma (TRAMP).

Studies in vitro suggest that osteopontin (OPN), an extracellular matrix protein secreted by macrophages infiltrating prostate tumors, and by tumor cells, may have a role in the transition from clinically insignificant tumors to metastatic prostate cancer (PC).

Our earlier studies in TRAnsgenic Mouse Prostate adenocarcinoma (TRAMP) mice showed that genistein, an isoflavone found in soybeans, lowered the incidence of advanced PC.

Administration of 250 and 500 mg genistein/kg AIN-76A improved survival (P = 0.008 and P = 0.005, respectively) and reduced mean weight of prostates with poorly differentiated cancer (PD) (P < 0.001), as well as the mean weight of periaortic lymph nodes (LN), although the latter was not significant.

OPN mRNA levels in the dorsolateral prostate and metastasis to LN were significantly correlated (r = 0.643; P = 0.00006).

Genistein had a dose-dependent, significant inhibitory effect on OPN transcript levels in prostates displaying advanced prostate cancer (PD; score 6; P = 0.05).

[MeSH-major] Adenocarcinoma / genetics. Genistein / pharmacology. Prostatic Neoplasms / genetics. Sialoglycoproteins / genetics. Soybean Proteins / therapeutic use

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(PMID = 15867270.001).

[ISSN] 0022-3166

[Journal-full-title] The Journal of nutrition

[ISO-abbreviation] J. Nutr.

[Language] eng

[Grant] United States / NCI NIH HHS / CA / CA 84926

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / RNA, Messenger; 0 / Sialoglycoproteins; 0 / Soybean Proteins; 0 / Spp1 protein, mouse; 106441-73-0 / Osteopontin; DH2M523P0H / Genistein

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Metastases in the paranasal sinuses secondary to prostatic adenocarcinoma].

[Transliterated title] Metástasis en senos paranasales secundaria a adenocarcinoma prostático.

OBJECTIVE: To report a new case of exceptional metastases from a prostatic carcinoma.

METHODS: 64-year-old male with nine months history of disseminated prostate cancer, taking hormonal treatment and biphosphonates, who presents with rising PSA, facial dysesthesia and left exophtalmos.

RESULTS: Once the diagnosis was established hormonal maneuvers were performed and chemotherapy with docetaxel was administered achieving at the start of treatment measurable disease stabilization with biochemical remission of PSA levels, followed posteriorly by progression without changes in the metastatic images.

CONCLUSIONS: 1% of the prostatic tumors involve the head in their evolution.

[MeSH-major] Adenocarcinoma / secondary. Paranasal Sinus Neoplasms / secondary. Prostatic Neoplasms / pathology

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(PMID = 18077874.001).

[ISSN] 0004-0614

[Journal-full-title] Archivos españoles de urología

[ISO-abbreviation] Arch. Esp. Urol.

[Language] spa

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Spain

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Epidemiologic profile and prognostic factors in clinically localized prostate adenocarcinoma submitted to surgical treatment].

[Transliterated title] Perfil epidemiológico e fatores prognósticos no tratamento cirúrgico do adenocarcinoma de próstata clinicamente localizado.

OBJECTIVE: Radical prostatectomy remains the standard treatment for early prostate cancer.

METHODS: A total of 500 patients with prostate cancer underwent radical prostatectomy at Santa Rita hospital- Maringa-PR, between 2000 and 2006.

Clinical staging, preoperative prostate-specific antigen (PSA) and Gleason score were evaluated with pathological stage and margin status.

[MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / surgery. Prostatectomy. Prostatic Neoplasms / epidemiology. Prostatic Neoplasms / surgery

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(PMID = 20076923.001).

[ISSN] 1809-4546

[Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões

[ISO-abbreviation] Rev Col Bras Cir

[Language] por

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Brazil

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastatic prostate adenocarcinoma presenting with pulmonary symptoms: a case report and review of the literature.

INTRODUCTION: Prostate cancer has a high tendency to spread to bone.

Few patients with prostate cancer present initially with symptomatic metastatic lung lesions and lymphadenopathy without any other concomitant distant dissemination.

Despite the absence of any detectable osseous lesions and with the presence of multiple hilar, mediastinal, para-aortic, and pelvic lymphadenopathy, the patient had a complete work-up in search for the primary adenocarcinoma.

His prostate specific antigen was 146 ng/ml and a prostatic biopsy done, revealing an acinar prostatic adenocarcinoma.

A tru-cut biopsy of a lung lesion under computed tomography guidance showed a metastatic prostatic adenocarcinoma positive for prostate specific antigen stain.

CONCLUSION: This case sheds light on an unusual metastatic pattern of prostatic adenocarcinoma.

It also emphasizes the importance of including prostate cancer in the differential diagnosis of men with adenocarcinoma of unknown origin.

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[Cites] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387.001]

[Cites] Urol Oncol. 2006 May-Jun;24(3):216-9 [16678051.001]

[Cites] Urol Int. 1998 Oct;61(1):17-21 [9792977.001]

[Cites] Cancer. 1995 Jun 1;75(11):2706-9 [7743474.001]

[Cites] Hum Pathol. 2000 May;31(5):578-83 [10836297.001]

[Cites] Cancer. 1984 Dec 15;54(12):3078-84 [6498785.001]

[Cites] Cancer. 1990 Apr 15;65(8):1843-6 [2317763.001]

[Cites] Mil Med. 2000 Dec;165(12):973-4 [11149072.001]

[Cites] Radiology. 1985 Mar;154(3):601-4 [2578678.001]

(PMID = 19014682.001).

[ISSN] 1757-1626

[Journal-full-title] Cases journal

[ISO-abbreviation] Cases J

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2590613

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Prognostic significance of cell proliferation, microvascular density and androgen receptor level in prostatic adenocarcinoma].

Our study was concerned with prognostic significance of immunophenotypical features of prostate adenocarcinoma such as Ki-67 proliferation, androgen receptors (AR), microvascular density (MVD) in the stroma and tumor glands.

[MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Neovascularization, Pathologic / metabolism. Prostatic Neoplasms / metabolism. Prostatic Neoplasms / pathology. Receptors, Androgen / metabolism

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(PMID = 20210018.001).

[ISSN] 0507-3758

[Journal-full-title] Voprosy onkologii

[ISO-abbreviation] Vopr Onkol

[Language] rus

[Publication-type] English Abstract; Journal Article

[Publication-country] Russia (Federation)

[Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Receptors, Androgen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Ureteric stricture secondary to unusual extension of prostatic adenocarcinoma.

This article describes an unusual finding in a patient who presented with an adenocarcinoma of the prostate and right hydronephrosis.

Cystoscopy showed an exophytic superficial transitional cell carcinoma (TCC) of the bladder and a transrectal biopsy of the prostate confirmed adenocarcinoma Gleason score 4+3.

Staging investigations (CT pelvis and bone scan) were negative; androgen deprivation therapy was therefore initiated for the prostatic adenocarcinoma.

With a working diagnosis of upper tract TCC, right open nephroureterectomy was performed.

Final histology showed prostatic adenocarcinoma infiltrating the adventitia of the entire ureter up to the level of the renal pelvis.

A rare cause of ureteric stricture, contiguous spread of prostatic adenocarcinoma, should be considered in the differential diagnosis of patients presenting with upper tract obstruction and a known history of prostatic adenocarcinoma.

[MeSH-major] Adenocarcinoma / pathology. Prostatic Neoplasms / pathology. Ureter / pathology. Ureteral Obstruction / etiology

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(PMID = 20156388.001).

[ISSN] 1195-9479

[Journal-full-title] The Canadian journal of urology

[ISO-abbreviation] Can J Urol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Canada

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Testicular metastasis of prostatic adenocarcinoma: a case report].

Metastasis of prostate adenocarcinoma to testis is an extremely rare occurrence.

Orchiectomy is necessary to confirm histopathological diagnosis.

Metastatic carcinoma of the prostate to the testis is a commonly accepted as a sign of disseminated disease.

We report a case of a 62-year-old patient who presented a prostatic carcinoma with a testicular metastasis.

[MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Testicular Neoplasms / secondary

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(PMID = 17489329.001).

[ISSN] 1166-7087

[Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie

[ISO-abbreviation] Prog. Urol.

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] France

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Metastasis of prostatic adenocarcinoma to the sphenoid sinus.

The presentation, diagnosis, and management of prostatic adenocarcinoma metastatic to the sphenoid sinus are reviewed.

A 67-year-old man with a history of prostatic adenocarcinoma presented with gradual left visual loss.

Operative biopsy of the lesion was significant for adenocarcinoma of the prostate.

When an otolaryngologist encounters a mass in the sphenoid sinus, he or she needs to consider a diverse differential diagnosis.

As in this clinical scenario of a patient with a history of prostatic adenocarcinoma, appropriate analysis would entail sending specimens for immunohistochemical staining, such as prostate-specific antigen and prostate-specific acid phosphatase.

Correct diagnosis is crucial, as these patients may achieve remission and prolonged survival with irradiation and/or hormonal therapy.

[MeSH-major] Adenocarcinoma / pathology. Paranasal Sinus Neoplasms / secondary. Prostatic Neoplasms / pathology. Sphenoid Sinus / pathology

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(PMID = 17044541.001).

[ISSN] 0003-4894

[Journal-full-title] The Annals of otology, rhinology, and laryngology

[ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Single small focus of prostate adenocarcinoma (< or = 1 mm and too small for grading) and clinical significant disease after radical prostatectomy.

OBJECTIVES: To determine whether a clinical significant adenocarcinoma of the cinoma (defined as a lesion < or =1 mm. and too small for grading) at needle biopsy, even repeated, and through prostate specific antigen (PSA), PSA density (PSAD) and free-to-total PSA ratio (f/t ratio).

METHODS: Retrospectively 79/1610 consecutive patients undergoing prostatic needle biopsies presented one small focus of prostatic adenocarcinoma < or =1 mm and too small for grading.

All patients were submitted to radical retropubic prostatectomy (RRP) and were divided into three groups: group A (28/79 patients, 35.4%) submitted to RRP after diagnosis of just one small focus of adenocarcinoma at first biopsy; group B (26/79 patients, 32.9%) submitted to RRP after two successive diagnoses of small focus of adenocarcinoma; group C (25/79 patients, 31.6%) submitted to RRP after diagnosis of adenocarcinoma larger than 1 mm at successive biopsy in which Gleason score had been applied.

The aim of this retrospective study is to analyze the correlation between a single small focus of adenocarcinoma by prostatic biopsy, even repeated, and the clinical significant disease on the following radical retropubic prostatectomy.

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(PMID = 16929604.001).

[ISSN] 1124-3562

[Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

[ISO-abbreviation] Arch Ital Urol Androl

[Language] ENG

[Publication-type] Comparative Study; Journal Article

[Publication-country] Italy

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Omental metastasis with malignant ascites: an unusual manifestation of prostatic adenocarcinoma.

Omental metastasis with malignant ascites from prostatic adenocarcinoma is rare.

Clinical examination revealed a hard prostate and blood biochemistry demonstrated an elevated prostate specific antigen level.

A Doppler ultrasound scan excluded deep venous thrombosis, but a CT scan of the abdomen revealed marked para-aortic lymphadenopathy and prostate gland biopsy confirmed prostatic adenocarcinoma.

Histology of the omental mass showed metastasis from the prostatic adenocarcinoma.

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[Cites] Urology. 1992 May;39(5):495-7 [1580050.001]

[Cites] Lymphology. 1990 Dec;23(4):183-6 [2077299.001]

[Cites] J Urol. 1973 Aug;110(2):232-4 [4722620.001]

[Cites] Urology. 2002 May;59(5):773 [11992926.001]

[Cites] Am J Med Sci. 2004 May;327(5):262-3 [15166746.001]

[Cites] Scand J Urol Nephrol. 2002;36(3):225-7 [12201941.001]

[Cites] Am J Med. 2001 Aug 15;111(3):245-6 [11545100.001]

[Cites] J Urol. 1968 Aug;100(2):183-7 [5658662.001]

(PMID = 18542809.001).

[ISSN] 1911-6470

[Journal-full-title] Canadian Urological Association journal = Journal de l'Association des urologues du Canada

[ISO-abbreviation] Can Urol Assoc J

[Language] eng

[Publication-type] Journal Article

[Publication-country] Canada

[Other-IDs] NLM/ PMC2422958

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Expression of kinase insert domain-containing receptor in prostate adenocarcinoma].

OBJECTIVE: To investigate the correlation between the expression of the kinase insert domain-containing receptor (KDR) and the histological grade of prostate adenocarcinoma.

METHODS: Forty-eight samples of prostate adenocarcinoma tissues and 20 samples of benign prostatic hypertrophy (BPH) tissues were studied by LsAB immunohistochemical staining.

RESULTS: The positive expression rate of KDR was 73% in prostate adenocarcinoma and 30% in BPH.

The expression of KDR was stronger in prostate adenocarcinoma, and there was no relationship between staining intensity and the histological grade of carcinoma.

CONCLUSION: KDR, expressed more highly in prostate adenocarcinoma, promises to be a new target in the treatment of prostate adenocarcinoma.

[MeSH-major] Adenocarcinoma / metabolism. Prostatic Hyperplasia / metabolism. Prostatic Neoplasms / metabolism. Receptors, Vascular Endothelial Growth Factor / biosynthesis. Vascular Endothelial Growth Factor Receptor-2 / biosynthesis

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(PMID = 17491265.001).

[ISSN] 1009-3591

[Journal-full-title] Zhonghua nan ke xue = National journal of andrology

[ISO-abbreviation] Zhonghua Nan Ke Xue

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

[Chemical-registry-number] EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Clinicopathological behavior of single focus prostate adenocarcinoma.

PURPOSE: With the increasing use of focal therapy for prostate adenocarcinoma a pathological basis for its appropriate application must be established.

We determined the clinicopathological characteristics and natural history of single focus prostate cancer since this entity seems to be the ideal target for focal therapy.

MATERIALS AND METHODS: We queried the Center for Prostate Disease Research database for all patients who underwent radical prostatectomy at Walter Reed Army Medical Center from 1993 through 2008.

Patients with single focus prostate adenocarcinoma were compared with those who had multifocal disease.

CONCLUSIONS: Single focus prostate cancer appears to have more aggressive behavior than multifocal disease.

[MeSH-major] Adenocarcinoma / pathology. Prostatic Neoplasms / pathology

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(PMID = 19836800.001).

[ISSN] 1527-3792

[Journal-full-title] The Journal of urology

[ISO-abbreviation] J. Urol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Lymphatic vessel densities of lymph node-negative prostate adenocarcinoma in Korea.

Although lymphatic vessel density (LVD) is associated with regional lymph node (LN) metastasis in prostate adenocarcinoma, no study is available that examines whether the LVD is correlated with prognostic factors other than LN metastasis in LN-negative prostate adenocarcinoma.

The aim of our study was to analyze intratumoral (IT), peritumoral (PT), and nontumoral (NT) LVDs, and to determine if there is a correlation between the LVD and the clinicopathological parameters in the Korean LN-negative prostate adenocarcinoma patients.

The IT-LVD was significantly lower in patients with larger tumor volume (P=0.029) and higher preoperative prostate-specific antigen level (P=0.008).

Our results suggest that IT- and PT-LVDs may increase in LN-negative prostate adenocarcinoma as a result of lymphangiogenesis, but IT lymphatics may decrease due to mechanical compression and destruction caused by proliferating tumor cells.

In addition, IT-LVD may be used as a prognostic factor in LN-negative prostate adenocarcinoma.

[MeSH-major] Adenocarcinoma / pathology. Lymphangiogenesis. Lymphatic Vessels / pathology. Prostatic Neoplasms / pathology

[MeSH-minor] Aged. Humans. Immunohistochemistry. Korea. Lymph Nodes / pathology. Male. Middle Aged. Prognosis. Prostate-Specific Antigen / blood

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(PMID = 19058917.001).

[ISSN] 1618-0631

[Journal-full-title] Pathology, research and practice

[ISO-abbreviation] Pathol. Res. Pract.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prostate-specific membrane antigen (PSMA) protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate adenocarcinoma: an immunohistochemical study using mutiple tumour tissue microarray technique.

AIMS: To determine prostate-specific membrane antigen (PSMA) expression in normal tissues and in 3161 benign and malignant tumours and subsequently to define its sensitivity and specificity in prostatic adenocarcinoma (PaC).

Furthermore, its sensitivity and specificity in differentiating PaC from urothelial cancer is 65.9% and 82.9%, respectively.

[MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Female. Humans. Immunohistochemistry. Male. Organ Specificity. Prostate / metabolism. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / metabolism. Reference Values. Sensitivity and Specificity. Tissue Array Analysis

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(PMID = 17448023.001).

[ISSN] 0309-0167

[Journal-full-title] Histopathology

[ISO-abbreviation] Histopathology

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Antigens, Surface; EC 3.4.17.21 / Glutamate Carboxypeptidase II; EC 3.4.17.21 / glutamate carboxypeptidase II, human

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Intraluminal crystalloids are highly associated with prostatic adenocarcinoma on concurrent biopsy specimens.

Prostatic crystalloids are intraluminal eosinophilic structures with variable size and shape.

Their presence has been described in conjunction with the occurrence of prostatic adenocarcinoma (pCA).

We herein report the association of crystalloids and pCA in a prospective trial utilizing an extended multi-site transrectal ultrasound-guided (TRUS) prostate biopsy protocol.

Indications for biopsy included a prostate-specific antigen (PSA) > or =4 ng/ml and/or abnormal digital rectal exam.

Overall cancer detection rate was 42.7%.

pCA was diagnosed in 66 (81.5%) of 81 patients with crystalloids, 70 (69.3%) of 101 patients with high-grade prostatic intraepithelial neoplasia (HGPIN), and 32 (84.2%) of 38 patients with both HGPIN and crystalloids on biopsy.

Multivariate analysis identified crystalloids (RR 4.53, 95% CI 2.30-8.88) and HGPIN (RR 3.20, 95% CI 1.84-5.57) as independent predictors of the presence of cancer on concurrent biopsy (P<0.001).

These findings suggest that the presence of crystalloids alone or in combination with HGPIN in prostate biopsies may be a more compelling indication for repeat biopsy than HGPIN alone.

[MeSH-major] Adenocarcinoma / pathology. Biomarkers, Tumor. Inclusion Bodies / pathology. Prostatic Neoplasms / pathology

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(PMID = 17325718.001).

[ISSN] 1365-7852

[Journal-full-title] Prostate cancer and prostatic diseases

[ISO-abbreviation] Prostate Cancer Prostatic Dis.

[Language] eng

[Publication-type] Clinical Trial; Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [The frequency and diagnostic value of microscopic signs of minimal prostate adenocarcinoma].

Prostate biopsy specimens from 64 patients were studied.

In most cases with minimal prostate adenocarcinoma, the tumor was limited by the organ and of moderate malignancy.

[MeSH-major] Adenocarcinoma / pathology. Prostatic Neoplasms / pathology

[MeSH-minor] Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Humans. Male. Middle Aged. Retrospective Studies

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(PMID = 17290889.001).

[ISSN] 0004-1955

[Journal-full-title] Arkhiv patologii

[ISO-abbreviation] Arkh. Patol.

[Language] rus

[Publication-type] English Abstract; Journal Article; Multicenter Study

[Publication-country] Russia (Federation)

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Clinical characteristics and primary treatment of prostate cancer in Sweden between 1996 and 2005.

OBJECTIVE: The incidence of prostate cancer is rising rapidly in Sweden and there is a need to better understand the pattern of diagnosis, tumor characteristics and treatment.

MATERIAL AND METHODS: Between 1996 and 2005, all new cases of adenocarcinoma of the prostate gland were intended to be registered in the National Prostate Cancer Register (NPCR).

This register contains information on diagnosing unit, date of diagnosis, cause of diagnosis, tumor grade, tumor stage according to the TNM classification in force, serum prostate-specific antigen (PSA) levels at diagnosis and primary treatment given within the first 6 months after diagnosis.

RESULTS: In total, 72,028 patients were registered, comprising >97% of all pertinent incident cases of prostate cancer in the Swedish Cancer Register (SCR).

During the study period there was a considerable decrease in median age at the time of diagnosis, a stage migration towards smaller tumors, a decrease in median serum PSA values at diagnosis, a decrease in the age-standardized incidence rate of men diagnosed with distant metastases or with a PSA level of > 100 ng/ml at diagnosis and an increase in the proportion of tumors with Gleason score <6.

Relatively large geographical differences in the median age at diagnosis and the age-standardized incidence of cases with category T1c tumors were observed.

In men with localized tumors and a PSA level of <20 ng/ml at diagnosis, expectant treatment was more commonly used in those aged > or =75 years than in those aged <75 years.

The patterns of diagnosis and treatment of prostate cancer vary considerably in different parts of Sweden.

The NPCR continues to be an important source for research, epidemiological surveillance of the incidence, diagnosis and treatment of prostate cancer.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / therapy

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Humans. Incidence. Infant. Infant, Newborn. Male. Middle Aged. Neoplasm Staging. Prostate-Specific Antigen / blood. Registries. Retrospective Studies. Sweden

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(PMID = 17934985.001).

[ISSN] 0036-5599

[Journal-full-title] Scandinavian journal of urology and nephrology

[ISO-abbreviation] Scand. J. Urol. Nephrol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Sweden

[Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen